-- dump date   	20140620_081126
-- class       	Genbank::misc_feature
-- table       	misc_feature_note
-- id	note
205921000001	chromosomal replication initiation protein; Reviewed; Region: dnaA; PRK00149
205921000002	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
205921000003	Walker A motif; other site
205921000004	ATP binding site [chemical binding]; other site
205921000005	Walker B motif; other site
205921000006	arginine finger; other site
205921000007	C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571
205921000008	DnaA box-binding interface [nucleotide binding]; other site
205921000009	DNA polymerase III subunit beta; Validated; Region: PRK05643
205921000010	Beta clamp domain.  The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria.  The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140
205921000011	putative DNA binding surface [nucleotide binding]; other site
205921000012	dimer interface [polypeptide binding]; other site
205921000013	beta-clamp/clamp loader binding surface; other site
205921000014	beta-clamp/translesion DNA polymerase binding surface; other site
205921000015	Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase [Lipid metabolism / General function prediction only]; Region: LCB5; COG1597
205921000016	Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781
205921000017	Bacterial protein of unknown function (DUF951); Region: DUF951; pfam06107
205921000018	GTP-binding protein YchF; Reviewed; Region: PRK09601
205921000019	YchF GTPase; Region: YchF; cd01900
205921000020	G1 box; other site
205921000021	GTP/Mg2+ binding site [chemical binding]; other site
205921000022	Switch I region; other site
205921000023	G2 box; other site
205921000024	Switch II region; other site
205921000025	G3 box; other site
205921000026	G4 box; other site
205921000027	G5 box; other site
205921000028	TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867
205921000029	Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462
205921000030	putative active site [active]
205921000031	catalytic residue [active]
205921000032	Transcription-repair coupling factor (superfamily II helicase) [DNA replication, recombination, and repair / Transcription]; Region: Mfd; COG1197
205921000033	CarD-like/TRCF domain; Region: CarD_TRCF; smart01058
205921000034	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
205921000035	ATP binding site [chemical binding]; other site
205921000036	putative Mg++ binding site [ion binding]; other site
205921000037	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
205921000038	nucleotide binding region [chemical binding]; other site
205921000039	ATP-binding site [chemical binding]; other site
205921000040	This domain is found in proteins necessary for strand-specific repair in DNA such as TRCF in Escherichia coli; Region: TRCF; smart00982
205921000041	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
205921000042	RNA binding surface [nucleotide binding]; other site
205921000043	Septum formation initiator [Cell division and chromosome partitioning]; Region: COG2919
205921000044	Septum formation initiator; Region: DivIC; pfam04977
205921000045	Beta-lactamase enzyme family; Region: Beta-lactamase2; pfam13354
205921000046	tRNA(Ile)-lysidine synthase MesJ [Cell cycle control, cell division, chromosome partitioning]; Region: MesJ; COG0037
205921000047	N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992
205921000048	Ligand Binding Site [chemical binding]; other site
205921000049	TilS substrate C-terminal domain; Region: TilS_C; smart00977
205921000050	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
205921000051	active site
205921000052	ATP-dependent Zn proteases [Posttranslational modification, protein turnover, chaperones]; Region: HflB; COG0465
205921000053	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
205921000054	Walker A motif; other site
205921000055	ATP binding site [chemical binding]; other site
205921000056	Walker B motif; other site
205921000057	arginine finger; other site
205921000058	Peptidase family M41; Region: Peptidase_M41; pfam01434
205921000059	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3883
205921000060	Enolase-superfamily, characterized by the presence of an enolate anion intermediate which is generated by abstraction of the alpha-proton of the carboxylate substrate by an active site residue and is stabilized by coordination to the essential Mg2+ ion; Region: enolase_like; cl17188
205921000061	Surface antigen [General function prediction only]; Region: COG3942
205921000062	CHAP domain; Region: CHAP; pfam05257
205921000063	ribose-phosphate pyrophosphokinase; Provisional; Region: PRK02269
205921000064	N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793
205921000065	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
205921000066	active site
205921000067	aromatic amino acid aminotransferase; Validated; Region: PRK07309
205921000068	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
205921000069	pyridoxal 5'-phosphate binding site [chemical binding]; other site
205921000070	homodimer interface [polypeptide binding]; other site
205921000071	catalytic residue [active]
205921000072	Recombination protein O N terminal; Region: RecO_N; pfam11967
205921000073	DNA repair protein RecO; Region: reco; TIGR00613
205921000074	Recombination protein O C terminal; Region: RecO_C; pfam02565
205921000075	CAAX protease self-immunity; Region: Abi; pfam02517
205921000076	putative phosphate acyltransferase; Provisional; Region: PRK05331
205921000077	acyl carrier protein; Provisional; Region: PRK12449
205921000078	phosphoribosylaminoimidazole-succinocarboxamide synthase; Reviewed; Region: PRK09362
205921000079	bacterial and archaeal 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_PurC; cd01415
205921000080	ATP binding site [chemical binding]; other site
205921000081	active site
205921000082	substrate binding site [chemical binding]; other site
205921000083	phosphoribosylformylglycinamidine synthase, clade II; Region: FGAM-synthase; TIGR01857
205921000084	AIR (aminoimidazole ribonucleotide) synthase related protein. This family includes Hydrogen expression/formation protein HypE, AIR synthases, FGAM (formylglycinamidine ribonucleotide) synthase and Selenophosphate synthetase (SelD). The N-terminal domain...; Region: PurM-like; cl10019
205921000085	PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203
205921000086	dimerization interface [polypeptide binding]; other site
205921000087	ATP binding site [chemical binding]; other site
205921000088	PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat2; cd02204
205921000089	dimerization interface [polypeptide binding]; other site
205921000090	ATP binding site [chemical binding]; other site
205921000091	Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740
205921000092	putative active site [active]
205921000093	catalytic triad [active]
205921000094	amidophosphoribosyltransferase; Provisional; Region: PRK07272
205921000095	Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of  glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715
205921000096	active site
205921000097	tetramer interface [polypeptide binding]; other site
205921000098	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
205921000099	active site
205921000100	phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385
205921000101	PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196
205921000102	dimerization interface [polypeptide binding]; other site
205921000103	putative ATP binding site [chemical binding]; other site
205921000104	phosphoribosylglycinamide formyltransferase; Reviewed; Region: purN; PRK05647
205921000105	Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645
205921000106	active site
205921000107	substrate binding site [chemical binding]; other site
205921000108	cosubstrate binding site; other site
205921000109	catalytic site [active]
205921000110	GNAT acetyltransferase; Region: GNAT_acetyltran; pfam12746
205921000111	bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881
205921000112	Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal  ATIC formylase domain that formylates...; Region: IMPCH; cd01421
205921000113	purine monophosphate binding site [chemical binding]; other site
205921000114	dimer interface [polypeptide binding]; other site
205921000115	putative catalytic residues [active]
205921000116	AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; smart00798
205921000117	AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; cl03362
205921000118	Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739
205921000119	Peptidase family M23; Region: Peptidase_M23; pfam01551
205921000120	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
205921000121	N-acetylmannosamine-6-phosphate epimerase (NanE) converts N-acetylmannosamine-6-phosphate to N-acetylglucosamine-6-phosphate. This reaction is part of the pathway that allows the usage of sialic acid as a carbohydrate source. Sialic acids are a family of...; Region: NanE; cd04729
205921000122	N-acetylmannosamine-6-phosphate 2-epimerase; Provisional; Region: PRK01130
205921000123	putative active site cavity [active]
205921000124	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
205921000125	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
205921000126	ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209
205921000127	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
205921000128	dimer interface [polypeptide binding]; other site
205921000129	ABC-ATPase subunit interface; other site
205921000130	putative PBP binding loops; other site
205921000131	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
205921000132	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
205921000133	dimer interface [polypeptide binding]; other site
205921000134	conserved gate region; other site
205921000135	putative PBP binding loops; other site
205921000136	ABC-ATPase subunit interface; other site
205921000137	Domain of unknown function (DUF386); Region: DUF386; cl01047
205921000138	Protein of unknown function, DUF624; Region: DUF624; pfam04854
205921000139	Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329
205921000140	Class I aldolases; Region: Aldolase_Class_I; cl17187
205921000141	catalytic residue [active]
205921000142	Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940
205921000143	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012
205921000144	nucleotide binding site [chemical binding]; other site
205921000145	Acetyl xylan esterase (AXE1); Region: AXE1; pfam05448
205921000146	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
205921000147	Transcriptional regulators [Transcription]; Region: RpiR; COG1737
205921000148	Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418
205921000149	RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013
205921000150	putative active site [active]
205921000151	phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885
205921000152	Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844
205921000153	Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Region: GARS_A; pfam01071
205921000154	Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843
205921000155	Phosphoribosylcarboxyaminoimidazole (NCAIR) mutase [Nucleotide transport and metabolism]; Region: PurE; COG0041
205921000156	phosphoribosylaminoimidazole carboxylase ATPase subunit; Reviewed; Region: PRK06019
205921000157	ATP-grasp domain; Region: ATP-grasp; pfam02222
205921000158	adenylosuccinate lyase; Provisional; Region: PRK07492
205921000159	Adenylsuccinate lyase (ASL)_subgroup 1; Region: Adenylsuccinate_lyase_1; cd01360
205921000160	tetramer interface [polypeptide binding]; other site
205921000161	active site
205921000162	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
205921000163	non-specific DNA binding site [nucleotide binding]; other site
205921000164	salt bridge; other site
205921000165	sequence-specific DNA binding site [nucleotide binding]; other site
205921000166	Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080
205921000167	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
205921000168	Walker A motif; other site
205921000169	ATP binding site [chemical binding]; other site
205921000170	Walker B motif; other site
205921000171	arginine finger; other site
205921000172	Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491
205921000173	Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394
205921000174	Low molecular weight phosphatase family; Region: LMWPc; cd00115
205921000175	active site
205921000176	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4642
205921000177	Predicted acyltransferases [Lipid metabolism]; Region: COG1835
205921000178	glucans biosynthesis protein; Provisional; Region: opgC; PRK03854
205921000179	SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053
205921000180	active site
205921000181	catalytic triad [active]
205921000182	oxyanion hole [active]
205921000183	bifunctional acetaldehyde-CoA/alcohol dehydrogenase; Provisional; Region: PRK13805
205921000184	Coenzyme A acylating aldehyde dehydrogenase (ACDH), ALDH family 20-like; Region: ALDH_F20_ACDH; cd07122
205921000185	putative catalytic cysteine [active]
205921000186	C-terminal alcohol dehydrogenase domain of the acetaldehyde dehydrogenase-alcohol dehydrogenase bifunctional two-domain protein (AAD); Region: AAD_C; cd08178
205921000187	putative active site [active]
205921000188	metal binding site [ion binding]; metal-binding site
205921000189	ethanol-active dehydrogenase/acetaldehyde-active reductase; Provisional; Region: PRK09422
205921000190	Cinnamyl alcohol dehydrogenases (CAD); Region: CAD3; cd08297
205921000191	NAD binding site [chemical binding]; other site
205921000192	substrate binding site [chemical binding]; other site
205921000193	catalytic Zn binding site [ion binding]; other site
205921000194	tetramer interface [polypeptide binding]; other site
205921000195	structural Zn binding site [ion binding]; other site
205921000196	Threonine synthase catalyzes the final step of threonine biosynthesis. The conversion of O-phosphohomoserine into threonine and inorganic phosphate is pyridoxal 5'-phosphate dependent. The Thr-synth_1 CD includes members from higher plants; Region: Thr-synth_2; cd01560
205921000197	Threonine synthase [Amino acid transport and metabolism]; Region: ThrC; COG0498
205921000198	pyridoxal 5'-phosphate binding site [chemical binding]; other site
205921000199	catalytic residue [active]
205921000200	Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534
205921000201	Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Thermotoga marina NorM; Region: MATE_NorM_like; cd13137
205921000202	30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596
205921000203	50S ribosomal protein L3; Validated; Region: rplC; PRK00001
205921000204	50S ribosomal protein L4; Provisional; Region: rplD; PRK05319
205921000205	50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738
205921000206	50S ribosomal protein L2; Validated; Region: rplB; PRK09374
205921000207	Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181
205921000208	Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947
205921000209	30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357
205921000210	Ribosomal protein L22/L17e.  L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit.  It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336
205921000211	putative translocon binding site; other site
205921000212	protein-rRNA interface [nucleotide binding]; other site
205921000213	30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310
205921000214	K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3  is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel.  The KH...; Region: 30S_S3_KH; cd02412
205921000215	G-X-X-G motif; other site
205921000216	Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189
205921000217	Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433
205921000218	23S rRNA interface [nucleotide binding]; other site
205921000219	5S rRNA interface [nucleotide binding]; other site
205921000220	putative antibiotic binding site [chemical binding]; other site
205921000221	L25 interface [polypeptide binding]; other site
205921000222	L27 interface [polypeptide binding]; other site
205921000223	Ribosomal L29 protein/HIP.  L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals.  L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427
205921000224	23S rRNA interface [nucleotide binding]; other site
205921000225	putative translocon interaction site; other site
205921000226	signal recognition particle (SRP54) interaction site; other site
205921000227	L23 interface [polypeptide binding]; other site
205921000228	trigger factor interaction site; other site
205921000229	30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610
205921000230	50S ribosomal protein L14; Validated; Region: rplN; PRK05483
205921000231	50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004
205921000232	KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089
205921000233	RNA binding site [nucleotide binding]; other site
205921000234	50S ribosomal protein L5; Validated; Region: rplE; PRK00010
205921000235	Ribosomal protein L5; Region: Ribosomal_L5; pfam00281
205921000236	ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673
205921000237	30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08061
205921000238	30S ribosomal protein S8; Validated; Region: rpsH; PRK00136
205921000239	50S ribosomal protein L6; Validated; Region: rplF; PRK05498
205921000240	Ribosomal protein L6; Region: Ribosomal_L6; pfam00347
205921000241	Ribosomal protein L6; Region: Ribosomal_L6; pfam00347
205921000242	Ribosomal L18/L5e:  L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432
205921000243	5S rRNA interface [nucleotide binding]; other site
205921000244	L27 interface [polypeptide binding]; other site
205921000245	23S rRNA interface [nucleotide binding]; other site
205921000246	L5 interface [polypeptide binding]; other site
205921000247	30S ribosomal protein S5; Validated; Region: rpsE; PRK00550
205921000248	Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333
205921000249	Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719
205921000250	Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins that...; Region: Ribosomal_L30; cd01658
205921000251	23S rRNA binding site [nucleotide binding]; other site
205921000252	50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592
205921000253	preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204
205921000254	SecY translocase; Region: SecY; pfam00344
205921000255	adenylate kinase; Reviewed; Region: adk; PRK00279
205921000256	Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428
205921000257	AMP-binding site [chemical binding]; other site
205921000258	ATP-AMP (Ap5A)-binding site [chemical binding]; other site
205921000259	S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451
205921000260	rRNA binding site [nucleotide binding]; other site
205921000261	predicted 30S ribosome binding site; other site
205921000262	Ribosomal protein S13 [Translation, ribosomal structure and biogenesis]; Region: RpsM; COG0099
205921000263	30S ribosomal protein S13; Region: bact_S13; TIGR03631
205921000264	30S ribosomal protein S11; Validated; Region: PRK05309
205921000265	DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182
205921000266	N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928
205921000267	alphaNTD homodimer interface [polypeptide binding]; other site
205921000268	alphaNTD - beta interaction site [polypeptide binding]; other site
205921000269	alphaNTD - beta' interaction site [polypeptide binding]; other site
205921000270	Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118
205921000271	50S ribosomal protein L17; Validated; Region: rplQ; PRK05591
205921000272	Bacterial protein of unknown function (DUF925); Region: DUF925; pfam06042
205921000273	Protein of unknown function (DUF2992); Region: DUF2992; pfam11208
205921000274	RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937
205921000275	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
205921000276	catalytic core [active]
205921000277	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
205921000278	D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: VanY; COG1876
205921000279	D-alanyl-D-alanine carboxypeptidase; Region: VanY; pfam02557
205921000280	Mannosyl-glycoprotein endo-beta-N-acetylglucosaminidase; Region: Glucosaminidase; cl17361
205921000281	heat-inducible transcription repressor; Provisional; Region: hrcA; PRK00082
205921000282	Winged helix-turn-helix transcription repressor, HrcA DNA-binding; Region: HrcA_DNA-bdg; pfam03444
205921000283	GrpE; Region: GrpE; pfam01025
205921000284	GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446
205921000285	dimer interface [polypeptide binding]; other site
205921000286	hsp70 (ATPase domain) interactions [polypeptide binding]; other site
205921000287	molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290
205921000288	Nucleotide-binding domain of human HSPA9 and similar proteins; Region: HSPA9-Ssq1-like_NBD; cd10234
205921000289	nucleotide binding site [chemical binding]; other site
205921000290	NEF interaction site [polypeptide binding]; other site
205921000291	SBD interface [polypeptide binding]; other site
205921000292	chaperone protein DnaJ; Provisional; Region: PRK14276
205921000293	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257
205921000294	HSP70 interaction site [polypeptide binding]; other site
205921000295	C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cl03262
205921000296	substrate binding site [polypeptide binding]; other site
205921000297	Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719
205921000298	Zn binding sites [ion binding]; other site
205921000299	C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747
205921000300	dimer interface [polypeptide binding]; other site
205921000301	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167
205921000302	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
205921000303	DNA-binding site [nucleotide binding]; DNA binding site
205921000304	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
205921000305	pyridoxal 5'-phosphate binding site [chemical binding]; other site
205921000306	homodimer interface [polypeptide binding]; other site
205921000307	catalytic residue [active]
205921000308	tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021
205921000309	Eukaryotic and bacterial pseudouridine synthases similar to E.  coli TruA; Region: PseudoU_synth_EcTruA; cd02570
205921000310	dimerization interface 3.5A [polypeptide binding]; other site
205921000311	active site
205921000312	4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169
205921000313	dimer interface [polypeptide binding]; other site
205921000314	substrate binding site [chemical binding]; other site
205921000315	ATP binding site [chemical binding]; other site
205921000316	ECF-type riboflavin transporter, S component; Region: ECF-ribofla_trS; pfam07155
205921000317	Protein of unknown function (DUF3816); Region: DUF3816; pfam12822
205921000318	hypothetical protein; Provisional; Region: PRK13690
205921000319	Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668
205921000320	Mechanosensitive ion channel; Region: MS_channel; pfam00924
205921000321	trigger factor; Provisional; Region: tig; PRK01490
205921000322	FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254
205921000323	Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698
205921000324	DNA-directed RNA polymerase delta subunit; Region: RNA_pol_delta; pfam05066
205921000325	CTP synthetase; Validated; Region: pyrG; PRK05380
205921000326	CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113
205921000327	Catalytic site [active]
205921000328	active site
205921000329	UTP binding site [chemical binding]; other site
205921000330	Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746
205921000331	active site
205921000332	putative oxyanion hole; other site
205921000333	catalytic triad [active]
205921000334	Hydrolases of the alpha/beta superfamily [General function prediction only]; Region: COG1073
205921000335	Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557
205921000336	trimer interface [polypeptide binding]; other site
205921000337	active site
205921000338	DNA repair protein RadA; Provisional; Region: PRK11823
205921000339	Sms (bacterial radA) DNA repair protein. This protein is not related to archael radA any more than is to other RecA-like NTPases. Sms has a role in recombination and recombinational repair and is responsible for the stabilization or processing of...; Region: Sms; cd01121
205921000340	Walker A motif/ATP binding site; other site
205921000341	ATP binding site [chemical binding]; other site
205921000342	Walker B motif; other site
205921000343	Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541
205921000344	Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeD; cd03379
205921000345	active site clefts [active]
205921000346	zinc binding site [ion binding]; other site
205921000347	dimer interface [polypeptide binding]; other site
205921000348	pyridine nucleotide-disulfide oxidoreductase; Provisional; Region: PRK07251
205921000349	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
205921000350	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
205921000351	Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826
205921000352	Helix-turn-helix domain; Region: HTH_38; pfam13936
205921000353	Integrase core domain; Region: rve; pfam00665
205921000354	glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406
205921000355	catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808
205921000356	active site
205921000357	HIGH motif; other site
205921000358	catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808
205921000359	active site
205921000360	KMSKS motif; other site
205921000361	D-ribose transporter subunit RbsB; Provisional; Region: PRK10653
205921000362	Periplasmic sugar-binding domain of the thermophilic Thermoanaerobacter tengcongensis ribose binding protein (ttRBP) and its mesophilic homologs; Region: PBP1_ribose_binding; cd06323
205921000363	ligand binding site [chemical binding]; other site
205921000364	dimerization interface [polypeptide binding]; other site
205921000365	Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579
205921000366	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
205921000367	TM-ABC transporter signature motif; other site
205921000368	ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129
205921000369	First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216
205921000370	Walker A/P-loop; other site
205921000371	ATP binding site [chemical binding]; other site
205921000372	Q-loop/lid; other site
205921000373	ABC transporter signature motif; other site
205921000374	Walker B; other site
205921000375	D-loop; other site
205921000376	H-loop/switch region; other site
205921000377	Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215
205921000378	D-ribose pyranase; Provisional; Region: PRK11797
205921000379	Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524
205921000380	Ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This reaction is the first step in the ribose metabolism. It traps ribose within the cell after uptake and also prepares the sugar for use in the synthesis of nucleotides...; Region: ribokinase; cd01174
205921000381	substrate binding site [chemical binding]; other site
205921000382	dimer interface [polypeptide binding]; other site
205921000383	ATP binding site [chemical binding]; other site
205921000384	Transcriptional regulators [Transcription]; Region: PurR; COG1609
205921000385	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
205921000386	DNA binding site [nucleotide binding]
205921000387	domain linker motif; other site
205921000388	Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011
205921000389	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
205921000390	ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577
205921000391	FtsX-like permease family; Region: FtsX; pfam02687
205921000392	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
205921000393	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
205921000394	Walker A/P-loop; other site
205921000395	ATP binding site [chemical binding]; other site
205921000396	Q-loop/lid; other site
205921000397	ABC transporter signature motif; other site
205921000398	Walker B; other site
205921000399	D-loop; other site
205921000400	H-loop/switch region; other site
205921000401	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
205921000402	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
205921000403	active site
205921000404	phosphorylation site [posttranslational modification]
205921000405	intermolecular recognition site; other site
205921000406	dimerization interface [polypeptide binding]; other site
205921000407	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
205921000408	DNA binding site [nucleotide binding]
205921000409	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
205921000410	HAMP domain; Region: HAMP; pfam00672
205921000411	dimerization interface [polypeptide binding]; other site
205921000412	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
205921000413	dimer interface [polypeptide binding]; other site
205921000414	phosphorylation site [posttranslational modification]
205921000415	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
205921000416	ATP binding site [chemical binding]; other site
205921000417	Mg2+ binding site [ion binding]; other site
205921000418	G-X-G motif; other site
205921000419	argininosuccinate synthase; Provisional; Region: PRK13820
205921000420	Argininosuccinate synthase. The Argininosuccinate synthase is a urea cycle enzyme that catalyzes the penultimate step in arginine biosynthesis: the ATP-dependent ligation of citrulline to aspartate to form argininosuccinate, AMP and pyrophosphate .  In...; Region: Argininosuccinate_Synthase; cd01999
205921000421	ANP binding site [chemical binding]; other site
205921000422	Substrate Binding Site II [chemical binding]; other site
205921000423	Substrate Binding Site I [chemical binding]; other site
205921000424	argininosuccinate lyase; Provisional; Region: PRK00855
205921000425	Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359
205921000426	active sites [active]
205921000427	tetramer interface [polypeptide binding]; other site
205921000428	fructose-bisphosphate aldolase; Provisional; Region: PRK09197
205921000429	Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947
205921000430	intersubunit interface [polypeptide binding]; other site
205921000431	active site
205921000432	zinc binding site [ion binding]; other site
205921000433	Na+ binding site [ion binding]; other site
205921000434	L-2-hydroxyisocapronate dehydrogenases and some bacterial L-lactate dehydrogenases; Region: HicDH_like; cd05291
205921000435	tetramer (dimer of dimers) interface [polypeptide binding]; other site
205921000436	L-lactate dehydrogenase; Region: L-LDH-NAD; TIGR01771
205921000437	NAD binding site [chemical binding]; other site
205921000438	dimer interface [polypeptide binding]; other site
205921000439	substrate binding site [chemical binding]; other site
205921000440	50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359
205921000441	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1302
205921000442	DAK2 domain fusion protein YloV; Region: YloV; TIGR03599
205921000443	DAK2 domain; Region: Dak2; pfam02734
205921000444	Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330
205921000445	A subgroup of the band 7 domain of flotillin (reggie) like proteins. This subgroup contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin.  Many of these band 7 domain-containing proteins are lipid raft-associated.  Individual...; Region: Band_7_4; cd03407
205921000446	Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826
205921000447	Helix-turn-helix domain; Region: HTH_38; pfam13936
205921000448	Integrase core domain; Region: rve; pfam00665
205921000449	Gram-positive signal peptide, YSIRK family; Region: YSIRK_signal; TIGR01168
205921000450	Immunoglobulin like; Region: IG_like; smart00410
205921000451	RICH domain; Region: RICH; pfam05062
205921000452	Cornifin (SPRR) family; Region: Cornifin; pfam02389
205921000453	Gram positive anchor; Region: Gram_pos_anchor; pfam00746
205921000454	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1755
205921000455	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
205921000456	HAMP domain; Region: HAMP; pfam00672
205921000457	dimerization interface [polypeptide binding]; other site
205921000458	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
205921000459	dimer interface [polypeptide binding]; other site
205921000460	phosphorylation site [posttranslational modification]
205921000461	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
205921000462	ATP binding site [chemical binding]; other site
205921000463	Mg2+ binding site [ion binding]; other site
205921000464	G-X-G motif; other site
205921000465	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
205921000466	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
205921000467	active site
205921000468	phosphorylation site [posttranslational modification]
205921000469	intermolecular recognition site; other site
205921000470	dimerization interface [polypeptide binding]; other site
205921000471	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
205921000472	DNA binding site [nucleotide binding]
205921000473	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3293
205921000474	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
205921000475	DDE superfamily endonuclease; Region: DDE_4_2; pfam13613
205921000476	ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126
205921000477	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
205921000478	Walker A/P-loop; other site
205921000479	ATP binding site [chemical binding]; other site
205921000480	Q-loop/lid; other site
205921000481	ABC transporter signature motif; other site
205921000482	Walker B; other site
205921000483	D-loop; other site
205921000484	H-loop/switch region; other site
205921000485	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
205921000486	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
205921000487	substrate binding pocket [chemical binding]; other site
205921000488	membrane-bound complex binding site; other site
205921000489	hinge residues; other site
205921000490	ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215
205921000491	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
205921000492	dimer interface [polypeptide binding]; other site
205921000493	conserved gate region; other site
205921000494	putative PBP binding loops; other site
205921000495	ABC-ATPase subunit interface; other site
205921000496	Predicted membrane protein (DUF2207); Region: DUF2207; pfam09972
205921000497	undecaprenyl pyrophosphate phosphatase; Reviewed; Region: PRK00281
205921000498	adaptor protein; Provisional; Region: PRK02315
205921000499	UDP-N-acetylmuramyl pentapeptide phosphotransferase/UDP-N- acetylglucosamine-1-phosphate transferase [Cell envelope biogenesis, outer membrane]; Region: Rfe; COG0472
205921000500	This subfamily contains Escherichia coli WecA, Bacillus subtilis TagO and related proteins. WecA is an UDP-N-acetylglucosamine (GlcNAc):undecaprenyl-phosphate (Und-P) GlcNAc-1-phosphate transferase that catalyzes the formation of a phosphodiester bond...; Region: GT_WecA_like; cd06853
205921000501	Mg++ binding site [ion binding]; other site
205921000502	putative catalytic motif [active]
205921000503	substrate binding site [chemical binding]; other site
205921000504	Cysteine desulfurase activator ATPase [Posttranslational modification, protein turnover, chaperones]; Region: sufC; COG0396
205921000505	ABC-type transport system involved in Fe-S cluster assembly, ATPase component; Region: ABC_FeS_Assembly; cd03217
205921000506	Walker A/P-loop; other site
205921000507	ATP binding site [chemical binding]; other site
205921000508	Q-loop/lid; other site
205921000509	ABC transporter signature motif; other site
205921000510	Walker B; other site
205921000511	D-loop; other site
205921000512	H-loop/switch region; other site
205921000513	Cysteine desulfurase activator SufB [Posttranslational modification, protein turnover, chaperones]; Region: SufB; COG0719
205921000514	FeS assembly protein SufD; Region: sufD; TIGR01981
205921000515	Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520
205921000516	Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453
205921000517	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
205921000518	catalytic residue [active]
205921000519	NifU homolog involved in Fe-S cluster formation [Energy production and conversion]; Region: IscU; COG0822
205921000520	Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664
205921000521	trimerization site [polypeptide binding]; other site
205921000522	active site
205921000523	cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814; cl03223
205921000524	FeS assembly protein SufB; Region: sufB; TIGR01980
205921000525	D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768
205921000526	Beta-lactamase enzyme family; Region: Beta-lactamase2; pfam13354
205921000527	D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: DacC; COG1686
205921000528	Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872
205921000529	Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; pfam07943
205921000530	ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166
205921000531	The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504
205921000532	peptide binding site [polypeptide binding]; other site
205921000533	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601
205921000534	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
205921000535	dimer interface [polypeptide binding]; other site
205921000536	conserved gate region; other site
205921000537	putative PBP binding loops; other site
205921000538	ABC-ATPase subunit interface; other site
205921000539	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173
205921000540	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
205921000541	dimer interface [polypeptide binding]; other site
205921000542	conserved gate region; other site
205921000543	putative PBP binding loops; other site
205921000544	ABC-ATPase subunit interface; other site
205921000545	ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444
205921000546	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
205921000547	Walker A/P-loop; other site
205921000548	ATP binding site [chemical binding]; other site
205921000549	Q-loop/lid; other site
205921000550	ABC transporter signature motif; other site
205921000551	Walker B; other site
205921000552	D-loop; other site
205921000553	H-loop/switch region; other site
205921000554	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
205921000555	ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124
205921000556	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
205921000557	Walker A/P-loop; other site
205921000558	ATP binding site [chemical binding]; other site
205921000559	Q-loop/lid; other site
205921000560	ABC transporter signature motif; other site
205921000561	Walker B; other site
205921000562	D-loop; other site
205921000563	H-loop/switch region; other site
205921000564	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352
205921000565	4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: ipk; PRK00128
205921000566	GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288
205921000567	GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544
205921000568	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
205921000569	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
205921000570	putative Zn2+ binding site [ion binding]; other site
205921000571	putative DNA binding site [nucleotide binding]; other site
205921000572	ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235
205921000573	cell division ATP-binding protein FtsE; Region: FtsE; TIGR02673
205921000574	ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108
205921000575	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
205921000576	ABC-ATPase subunit  interface; other site
205921000577	dimer interface [polypeptide binding]; other site
205921000578	putative PBP binding regions; other site
205921000579	DNA/RNA non-specific endonuclease; Region: Endonuclease_NS; smart00892
205921000580	DNA/RNA non-specific endonuclease; Region: Endonuclea_NS_2; cl17626
205921000581	tyrosyl-tRNA synthetase; Validated; Region: PRK05912
205921000582	catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805
205921000583	active site
205921000584	HIGH motif; other site
205921000585	dimer interface [polypeptide binding]; other site
205921000586	KMSKS motif; other site
205921000587	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
205921000588	RNA binding surface [nucleotide binding]; other site
205921000589	Membrane carboxypeptidase (penicillin-binding protein) [Cell envelope biogenesis, outer membrane]; Region: MrcB; COG0744
205921000590	Transglycosylase; Region: Transgly; pfam00912
205921000591	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760
205921000592	RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585
205921000593	RNA polymerase Rpb2, domain 2; Region: RNA_pol_Rpb2_2; pfam04561
205921000594	DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405
205921000595	RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653
205921000596	RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653
205921000597	RPB1 interaction site [polypeptide binding]; other site
205921000598	RPB10 interaction site [polypeptide binding]; other site
205921000599	RPB11 interaction site [polypeptide binding]; other site
205921000600	RPB3 interaction site [polypeptide binding]; other site
205921000601	RPB12 interaction site [polypeptide binding]; other site
205921000602	DNA-directed RNA polymerase subunit beta'; Provisional; Region: PRK00566
205921000603	RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997
205921000604	RNA polymerase I subunit A N-terminus; Region: RPOLA_N; smart00663
205921000605	RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983
205921000606	RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000
205921000607	Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655
205921000608	Rpb1 (beta') - Rpb6 (omega) interaction site [polypeptide binding]; other site
205921000609	G-loop; other site
205921000610	Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655
205921000611	DNA binding site [nucleotide binding]
205921000612	Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site
205921000613	Protein of unknown function (DUF1033); Region: DUF1033; pfam06279
205921000614	Type II/IV secretion system protein; Region: T2SE; pfam00437
205921000615	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
205921000616	Walker A motif; other site
205921000617	ATP binding site [chemical binding]; other site
205921000618	Walker B motif; other site
205921000619	Type II secretory pathway, component PulF [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulF; COG1459
205921000620	Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482
205921000621	Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482
205921000622	Competence protein ComGC [Intracellular trafficking and secretion]; Region: ComGC; COG4537
205921000623	Type II secretory pathway pseudopilin; Region: PulG; pfam11773
205921000624	Competence protein ComGF [Intracellular trafficking and secretion]; Region: ComGF; COG4940
205921000625	Adenine-specific DNA methylase [DNA replication, recombination, and repair]; Region: COG0827
205921000626	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
205921000627	S-adenosylmethionine binding site [chemical binding]; other site
205921000628	acetate kinase A/propionate kinase 2; Reviewed; Region: PRK00180
205921000629	propionate/acetate kinase; Provisional; Region: PRK12379
205921000630	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
205921000631	non-specific DNA binding site [nucleotide binding]; other site
205921000632	salt bridge; other site
205921000633	sequence-specific DNA binding site [nucleotide binding]; other site
205921000634	CAAX protease self-immunity; Region: Abi; pfam02517
205921000635	NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232
205921000636	pyrroline-5-carboxylate reductase; Reviewed; Region: PRK11880
205921000637	Cellulase M and related proteins [Carbohydrate transport and metabolism]; Region: FrvX; COG1363
205921000638	M42 Peptidases, also known as glutamyl aminopeptidase family; Region: M42; cd05638
205921000639	oligomer interface [polypeptide binding]; other site
205921000640	active site
205921000641	metal binding site [ion binding]; metal-binding site
205921000642	TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947
205921000643	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
205921000644	catalytic residues [active]
205921000645	tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain.  PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796
205921000646	putative tRNA-binding site [nucleotide binding]; other site
205921000647	Methyltransferase domain; Region: Methyltransf_23; pfam13489
205921000648	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
205921000649	S-adenosylmethionine binding site [chemical binding]; other site
205921000650	Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629
205921000651	SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496
205921000652	dimer interface [polypeptide binding]; other site
205921000653	ssDNA binding site [nucleotide binding]; other site
205921000654	tetramer (dimer of dimers) interface [polypeptide binding]; other site
205921000655	Predicted phosphatase/phosphohexomutase [General function prediction only]; Region: COG0637
205921000656	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
205921000657	motif II; other site
205921000658	Putative regulator of cell autolysis [Signal transduction mechanisms]; Region: LytS; COG3275
205921000659	5TMR of 5TMR-LYT; Region: 5TM-5TMR_LYT; pfam07694
205921000660	GAF domain; Region: GAF_3; pfam13492
205921000661	Histidine kinase; Region: His_kinase; pfam06580
205921000662	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
205921000663	ATP binding site [chemical binding]; other site
205921000664	Mg2+ binding site [ion binding]; other site
205921000665	G-X-G motif; other site
205921000666	two-component response regulator; Provisional; Region: PRK14084
205921000667	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
205921000668	active site
205921000669	phosphorylation site [posttranslational modification]
205921000670	intermolecular recognition site; other site
205921000671	dimerization interface [polypeptide binding]; other site
205921000672	LytTr DNA-binding domain; Region: LytTR; pfam04397
205921000673	LrgA family; Region: LrgA; cl00608
205921000674	LrgB-like family; Region: LrgB; cl00596
205921000675	ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747
205921000676	The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_19; cd08518
205921000677	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601
205921000678	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
205921000679	dimer interface [polypeptide binding]; other site
205921000680	conserved gate region; other site
205921000681	putative PBP binding loops; other site
205921000682	ABC-ATPase subunit interface; other site
205921000683	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173
205921000684	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
205921000685	dimer interface [polypeptide binding]; other site
205921000686	conserved gate region; other site
205921000687	putative PBP binding loops; other site
205921000688	ABC-ATPase subunit interface; other site
205921000689	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
205921000690	nickel import ATP-binding protein NikD; Region: nickel_nikD; TIGR02770
205921000691	Walker A/P-loop; other site
205921000692	ATP binding site [chemical binding]; other site
205921000693	Q-loop/lid; other site
205921000694	ABC transporter signature motif; other site
205921000695	Walker B; other site
205921000696	D-loop; other site
205921000697	H-loop/switch region; other site
205921000698	ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122
205921000699	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
205921000700	Walker A/P-loop; other site
205921000701	ATP binding site [chemical binding]; other site
205921000702	Q-loop/lid; other site
205921000703	ABC transporter signature motif; other site
205921000704	Walker B; other site
205921000705	D-loop; other site
205921000706	H-loop/switch region; other site
205921000707	PTS system, trehalose-specific IIBC component; Region: PTS-IIBC-Tre; TIGR01992
205921000708	PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212
205921000709	active site turn [active]
205921000710	phosphorylation site [posttranslational modification]
205921000711	Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263
205921000712	Phosphotransferase system IIA components [Carbohydrate transport and metabolism]; Region: NagE; COG2190
205921000713	HPr interaction site; other site
205921000714	glycerol kinase (GK) interaction site [polypeptide binding]; other site
205921000715	active site
205921000716	phosphorylation site [posttranslational modification]
205921000717	alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403
205921000718	Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333
205921000719	Ca binding site [ion binding]; other site
205921000720	active site
205921000721	catalytic site [active]
205921000722	Transcriptional antiterminator [Transcription]; Region: BglG; COG3711
205921000723	PRD domain; Region: PRD; pfam00874
205921000724	PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568
205921000725	active site
205921000726	P-loop; other site
205921000727	phosphorylation site [posttranslational modification]
205921000728	PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211
205921000729	active site
205921000730	phosphorylation site [posttranslational modification]
205921000731	PTS_IIB_ascorbate: subunit IIB of enzyme II (EII) of the L-ascorbate-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is an L-ascorbate-specific permease with two cytoplasmic subunits (IIA and IIB) and a...; Region: PTS_IIB_ascorbate; cd05563
205921000732	active site
205921000733	P-loop; other site
205921000734	phosphorylation site [posttranslational modification]
205921000735	PTS system ascorbate-specific transporter subunit IIC; Reviewed; Region: ulaA; PRK09410
205921000736	Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012
205921000737	TPP-binding site [chemical binding]; other site
205921000738	dimer interface [polypeptide binding]; other site
205921000739	Transketolase, C-terminal subunit [Carbohydrate transport and metabolism]; Region: COG3958
205921000740	Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033
205921000741	PYR/PP interface [polypeptide binding]; other site
205921000742	dimer interface [polypeptide binding]; other site
205921000743	TPP binding site [chemical binding]; other site
205921000744	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
205921000745	Ferric reductase like transmembrane component; Region: Ferric_reduct; pfam01794
205921000746	NAD(P) binding domain of  ferredoxin reductase-like proteins catalyze electron transfer between an NAD(P)-binding sub-domain of the alpha/beta class and a discrete (usually N-terminal) domain, which varies in orientation with respect to the NAD(P)...; Region: FNR_like_3; cd06198
205921000747	FAD binding pocket [chemical binding]; other site
205921000748	FAD binding motif [chemical binding]; other site
205921000749	phosphate binding motif [ion binding]; other site
205921000750	beta-alpha-beta structure motif; other site
205921000751	NAD binding pocket [chemical binding]; other site
205921000752	Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353
205921000753	16S/18S rRNA binding site [nucleotide binding]; other site
205921000754	S13e-L30e interaction site [polypeptide binding]; other site
205921000755	25S rRNA binding site [nucleotide binding]; other site
205921000756	polynucleotide phosphorylase/polyadenylase; Provisional; Region: PRK11824
205921000757	Polyribonucleotide nucleotidyltransferase, repeat 1; Region: RNase_PH_PNPase_1; cd11363
205921000758	RNase E interface [polypeptide binding]; other site
205921000759	trimer interface [polypeptide binding]; other site
205921000760	Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364
205921000761	RNase E interface [polypeptide binding]; other site
205921000762	trimer interface [polypeptide binding]; other site
205921000763	active site
205921000764	Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393
205921000765	S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase  is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472
205921000766	RNA binding site [nucleotide binding]; other site
205921000767	domain interface; other site
205921000768	Serine acetyltransferase [Amino acid transport and metabolism]; Region: CysE; COG1045
205921000769	Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354
205921000770	trimer interface [polypeptide binding]; other site
205921000771	active site
205921000772	substrate binding site [chemical binding]; other site
205921000773	cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260
205921000774	catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672
205921000775	active site
205921000776	HIGH motif; other site
205921000777	catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672
205921000778	KMSKS motif; other site
205921000779	Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020
205921000780	tRNA binding surface [nucleotide binding]; other site
205921000781	anticodon binding site; other site
205921000782	RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593
205921000783	active site
205921000784	metal binding site [ion binding]; metal-binding site
205921000785	dimerization interface [polypeptide binding]; other site
205921000786	rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566
205921000787	RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032
205921000788	SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588
205921000789	YacP-like NYN domain; Region: NYN_YacP; cl01491
205921000790	EDD domain protein, DegV family; Region: DegV; TIGR00762
205921000791	Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645
205921000792	Ribosomal protein L13.  Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392
205921000793	23S rRNA interface [nucleotide binding]; other site
205921000794	L3 interface [polypeptide binding]; other site
205921000795	30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132
205921000796	Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582
205921000797	phiLC3 phage and phage-related integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes various bacterial (mainly gram positive) and phage integrases, including those similar to Lactococcus...; Region: INT_phiLC3_C; cd01189
205921000798	Int/Topo IB signature motif; other site
205921000799	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
205921000800	sequence-specific DNA binding site [nucleotide binding]; other site
205921000801	salt bridge; other site
205921000802	Replication initiator protein A (RepA) N-terminus; Region: RepA_N; pfam06970
205921000803	Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388
205921000804	Replication initiation factor; Region: Rep_trans; pfam02486
205921000805	Plasmid recombination enzyme; Region: Mob_Pre; pfam01076
205921000806	addiction module toxin, RelE/StbE family; Region: RelE_StbE; TIGR02385
205921000807	WXG100 family type VII secretion target; Region: WXG100_ESAT6; TIGR03930
205921000808	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
205921000809	non-specific DNA binding site [nucleotide binding]; other site
205921000810	salt bridge; other site
205921000811	sequence-specific DNA binding site [nucleotide binding]; other site
205921000812	transcriptional activator, Rgg/GadR/MutR family, C-terminal domain; Region: RGG_Cterm; TIGR01716
205921000813	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
205921000814	H+ Antiporter protein; Region: 2A0121; TIGR00900
205921000815	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
205921000816	dimer interface [polypeptide binding]; other site
205921000817	conserved gate region; other site
205921000818	ABC-ATPase subunit interface; other site
205921000819	Periplasmic glycine betaine/choline-binding (lipo)protein of an ABC-type transport system (osmoprotectant binding protein) [Cell envelope biogenesis, outer membrane]; Region: OpuBC; COG1732
205921000820	ABC-type proline/glycine betaine transport systems, periplasmic components [Amino acid transport and metabolism]; Region: ProX; cl17891
205921000821	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
205921000822	dimer interface [polypeptide binding]; other site
205921000823	conserved gate region; other site
205921000824	putative PBP binding loops; other site
205921000825	ABC-ATPase subunit interface; other site
205921000826	ABC-type proline/glycine betaine transport systems, ATPase components [Amino acid transport and metabolism]; Region: OpuBA; COG1125
205921000827	ATP-binding cassette domain of the osmoprotectant transporter; Region: ABC_OpuCA_Osmoprotection; cd03295
205921000828	Walker A/P-loop; other site
205921000829	ATP binding site [chemical binding]; other site
205921000830	Q-loop/lid; other site
205921000831	ABC transporter signature motif; other site
205921000832	Walker B; other site
205921000833	D-loop; other site
205921000834	H-loop/switch region; other site
205921000835	FOG: CBS domain [General function prediction only]; Region: COG0517
205921000836	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in association with the ABC transporter OpuCA. OpuCA is the ATP binding component of a bacterial solute transporter that serves a protective role to cells growing...; Region: CBS_pair_ABC_OpuCA_assoc2; cd04583
205921000837	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3666
205921000838	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
205921000839	Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751
205921000840	Lipase.  Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is "interfacial activation", the process of...; Region: Lipase; cl14883
205921000841	nucleophilic elbow; other site
205921000842	catalytic triad; other site
205921000843	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
205921000844	non-specific DNA binding site [nucleotide binding]; other site
205921000845	salt bridge; other site
205921000846	sequence-specific DNA binding site [nucleotide binding]; other site
205921000847	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
205921000848	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
205921000849	Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670
205921000850	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
205921000851	Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670
205921000852	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
205921000853	Sigma factor regulator C-terminal; Region: Sigma_reg_C; pfam13791
205921000854	DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595
205921000855	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
205921000856	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
205921000857	DNA binding residues [nucleotide binding]
205921000858	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
205921000859	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
205921000860	ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842
205921000861	ABC-2 type transporter; Region: ABC2_membrane; pfam01061
205921000862	ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555
205921000863	ATP-binding cassette domain of the lipid transporters, subfamily A; Region: ABC_subfamily_A; cd03263
205921000864	Walker A/P-loop; other site
205921000865	ATP binding site [chemical binding]; other site
205921000866	Q-loop/lid; other site
205921000867	ABC transporter signature motif; other site
205921000868	Walker B; other site
205921000869	D-loop; other site
205921000870	H-loop/switch region; other site
205921000871	Predicted transcriptional regulators [Transcription]; Region: COG1695
205921000872	Transcriptional regulator PadR-like family; Region: PadR; pfam03551
205921000873	N-acetylglucosamine-6-phosphate deacetylase [Carbohydrate transport and metabolism]; Region: NagA; COG1820
205921000874	N-acetylglucosamine-6-phosphate deacetylase, NagA, catalyzes the hydrolysis of the N-acetyl group of N-acetyl-glucosamine-6-phosphate (GlcNAc-6-P) to glucosamine 6-phosphate and acetate. This is the first committed step in the biosynthetic pathway to...; Region: NagA; cd00854
205921000875	active site
205921000876	dimer interface [polypeptide binding]; other site
205921000877	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1755
205921000878	Class II Glycyl-tRNA synthetase (GlyRS) alpha subunit core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes and in arabidopsis. It is responsible for the...; Region: GlyRS_alpha_core; cd00733
205921000879	dimer interface [polypeptide binding]; other site
205921000880	motif 1; other site
205921000881	active site
205921000882	motif 2; other site
205921000883	motif 3; other site
205921000884	Flavodoxin-like fold; Region: Flavodoxin_2; cl00438
205921000885	glycyl-tRNA synthetase subunit beta; Validated; Region: glyS; PRK01233
205921000886	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl17215
205921000887	DALR anticodon binding domain; Region: DALR_1; pfam05746
205921000888	hypothetical protein; Provisional; Region: PRK02539
205921000889	Predicted membrane protein [Function unknown]; Region: COG3326
205921000890	glycerol kinase; Provisional; Region: glpK; PRK00047
205921000891	Escherichia coli glycerol kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_EcGK_like; cd07786
205921000892	N- and C-terminal domain interface [polypeptide binding]; other site
205921000893	active site
205921000894	MgATP binding site [chemical binding]; other site
205921000895	catalytic site [active]
205921000896	metal binding site [ion binding]; metal-binding site
205921000897	glycerol binding site [chemical binding]; other site
205921000898	homotetramer interface [polypeptide binding]; other site
205921000899	homodimer interface [polypeptide binding]; other site
205921000900	FBP binding site [chemical binding]; other site
205921000901	protein IIAGlc interface [polypeptide binding]; other site
205921000902	Glycerol-3-phosphate dehydrogenase [Energy production and conversion]; Region: GlpA; COG0578
205921000903	Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cd00333
205921000904	amphipathic channel; other site
205921000905	Asn-Pro-Ala signature motifs; other site
205921000906	Uncharacterized NAD(FAD)-dependent dehydrogenases [General function prediction only]; Region: HcaD; COG0446
205921000907	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
205921000908	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
205921000909	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
205921000910	Mga helix-turn-helix domain; Region: Mga; pfam05043
205921000911	Transketolase [Carbohydrate transport and metabolism]; Region: TktA; COG0021
205921000912	Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012
205921000913	TPP-binding site [chemical binding]; other site
205921000914	dimer interface [polypeptide binding]; other site
205921000915	Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033
205921000916	PYR/PP interface [polypeptide binding]; other site
205921000917	dimer interface [polypeptide binding]; other site
205921000918	TPP binding site [chemical binding]; other site
205921000919	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
205921000920	Enterocin A Immunity; Region: EntA_Immun; pfam08951
205921000921	ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555
205921000922	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
205921000923	Walker A/P-loop; other site
205921000924	ATP binding site [chemical binding]; other site
205921000925	Q-loop/lid; other site
205921000926	ABC transporter signature motif; other site
205921000927	Walker B; other site
205921000928	D-loop; other site
205921000929	H-loop/switch region; other site
205921000930	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
205921000931	PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212
205921000932	PTS system, sucrose-specific IIBC component; Region: PTS-II-BC-sucr; TIGR01996
205921000933	active site turn [active]
205921000934	phosphorylation site [posttranslational modification]
205921000935	Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263
205921000936	Glutamate 5-kinase [Amino acid transport and metabolism]; Region: ProB; COG0263
205921000937	AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242
205921000938	nucleotide binding site [chemical binding]; other site
205921000939	homotetrameric interface [polypeptide binding]; other site
205921000940	putative phosphate binding site [ion binding]; other site
205921000941	putative allosteric binding site; other site
205921000942	Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079
205921000943	gamma-glutamyl phosphate reductase; Region: proA; TIGR00407
205921000944	putative catalytic cysteine [active]
205921000945	Predicted S-adenosylmethionine-dependent methyltransferase involved in cell envelope biogenesis [Cell envelope biogenesis, outer membrane]; Region: COG0275
205921000946	MraW methylase family; Region: Methyltransf_5; pfam01795
205921000947	Protein required for the initiation of cell division [Cell division and chromosome partitioning]; Region: FtsL; COG4839
205921000948	Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768
205921000949	Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717
205921000950	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905
205921000951	PASTA domain of PBP2x-like proteins, first repeat. Penicillin-binding proteins (PBPs) are the major targets for beta-lactam antibiotics, like penicillins and cephalosporins. Beta-lactam antibiotics specifically inhibit transpeptidase activity by...; Region: PASTA_Pbp2x-like_1; cd06576
205921000952	PASTA domain of PBP2x-like proteins, second repeat. Penicillin-binding proteins (PBPs) are the major targets for beta-lactam antibiotics, like penicillins and cephalosporins. Beta-lactam antibiotics specifically inhibit transpeptidase activity by...; Region: PASTA_Pbp2x-like_2; cd06575
205921000953	phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108
205921000954	Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852
205921000955	Mg++ binding site [ion binding]; other site
205921000956	putative catalytic motif [active]
205921000957	putative substrate binding site [chemical binding]; other site
205921000958	DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker  B motif; Region: DEADc; cd00268
205921000959	DEAD-like helicases superfamily; Region: DEXDc; smart00487
205921000960	ATP binding site [chemical binding]; other site
205921000961	Mg++ binding site [ion binding]; other site
205921000962	motif III; other site
205921000963	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
205921000964	nucleotide binding region [chemical binding]; other site
205921000965	ATP-binding site [chemical binding]; other site
205921000966	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
205921000967	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
205921000968	substrate binding pocket [chemical binding]; other site
205921000969	membrane-bound complex binding site; other site
205921000970	hinge residues; other site
205921000971	ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215
205921000972	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
205921000973	dimer interface [polypeptide binding]; other site
205921000974	conserved gate region; other site
205921000975	putative PBP binding loops; other site
205921000976	ABC-ATPase subunit interface; other site
205921000977	ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126
205921000978	ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262
205921000979	Walker A/P-loop; other site
205921000980	ATP binding site [chemical binding]; other site
205921000981	Q-loop/lid; other site
205921000982	ABC transporter signature motif; other site
205921000983	Walker B; other site
205921000984	D-loop; other site
205921000985	H-loop/switch region; other site
205921000986	Protein of unknown function (DUF4059); Region: DUF4059; pfam13268
205921000987	thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292
205921000988	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
205921000989	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
205921000990	nicotinate phosphoribosyltransferase; Validated; Region: PRK09243
205921000991	Nicotinate phosphoribosyltransferase (NAPRTase), subgroup A. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting, reaction...; Region: NAPRTase_A; cd01570
205921000992	active site
205921000993	NAD synthase [Coenzyme metabolism]; Region: NadE; COG0171
205921000994	NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553
205921000995	homodimer interface [polypeptide binding]; other site
205921000996	NAD binding pocket [chemical binding]; other site
205921000997	ATP binding pocket [chemical binding]; other site
205921000998	Mg binding site [ion binding]; other site
205921000999	active-site loop [active]
205921001000	Peptidase C1B subfamily (MEROPS database nomenclature); composed of eukaryotic bleomycin hydrolases (BH) and bacterial aminopeptidases C (pepC). The proteins of this subfamily contain a large insert relative to the C1A peptidase (papain) subfamily. BH is...; Region: Peptidase_C1B; cd00585
205921001001	trimer interface [polypeptide binding]; other site
205921001002	active site
205921001003	G bulge; other site
205921001004	Transglycosylase; Region: Transgly; pfam00912
205921001005	penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074
205921001006	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760
205921001007	Holliday junction-specific endonuclease; Reviewed; Region: recU; PRK02234
205921001008	hypothetical protein; Provisional; Region: PRK13660
205921001009	cell division protein GpsB; Provisional; Region: PRK14127
205921001010	DivIVA domain; Region: DivI1A_domain; TIGR03544
205921001011	Predicted N6-adenine-specific DNA methylase [DNA replication, recombination, and repair]; Region: COG0116
205921001012	THUMP domain associated with S-adenosylmethionine-dependent methyltransferases; Region: THUMP_AdoMetMT; cd11715
205921001013	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173
205921001014	S-ribosylhomocysteinase; Provisional; Region: PRK02260
205921001015	hypothetical protein; Provisional; Region: PRK00106
205921001016	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
205921001017	Zn2+ binding site [ion binding]; other site
205921001018	Mg2+ binding site [ion binding]; other site
205921001019	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
205921001020	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
205921001021	Walker A/P-loop; other site
205921001022	ATP binding site [chemical binding]; other site
205921001023	Q-loop/lid; other site
205921001024	ABC transporter signature motif; other site
205921001025	Walker B; other site
205921001026	D-loop; other site
205921001027	H-loop/switch region; other site
205921001028	ABC-2 type transporter; Region: ABC2_membrane; cl17235
205921001029	ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698
205921001030	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585
205921001031	Cytidylyltransferase family; Region: CTP_transf_1; cl17467
205921001032	Histidine kinase; Region: HisKA_3; pfam07730
205921001033	Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518
205921001034	Mg2+ binding site [ion binding]; other site
205921001035	G-X-G motif; other site
205921001036	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
205921001037	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
205921001038	active site
205921001039	phosphorylation site [posttranslational modification]
205921001040	intermolecular recognition site; other site
205921001041	dimerization interface [polypeptide binding]; other site
205921001042	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
205921001043	DNA binding residues [nucleotide binding]
205921001044	dimerization interface [polypeptide binding]; other site
205921001045	Protein of unknown function (DUF1211); Region: DUF1211; pfam06736
205921001046	Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194
205921001047	Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071
205921001048	catalytic site [active]
205921001049	G-X2-G-X-G-K; other site
205921001050	DNA-directed RNA polymerase subunit omega; Reviewed; Region: rpoZ; PRK00392
205921001051	Primosomal protein N' (replication factor Y) - superfamily II helicase [DNA replication, recombination, and repair]; Region: PriA; COG1198
205921001052	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
205921001053	ATP binding site [chemical binding]; other site
205921001054	putative Mg++ binding site [ion binding]; other site
205921001055	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
205921001056	ATP-binding site [chemical binding]; other site
205921001057	methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005
205921001058	Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646
205921001059	putative active site [active]
205921001060	substrate binding site [chemical binding]; other site
205921001061	putative cosubstrate binding site; other site
205921001062	catalytic site [active]
205921001063	C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704
205921001064	substrate binding site [chemical binding]; other site
205921001065	16S rRNA methyltransferase B; Provisional; Region: PRK14902
205921001066	NusB family; Region: NusB; pfam01029
205921001067	putative RNA binding site [nucleotide binding]; other site
205921001068	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
205921001069	S-adenosylmethionine binding site [chemical binding]; other site
205921001070	Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143
205921001071	active site
205921001072	Protein phosphatase 2C; Region: PP2C; pfam00481
205921001073	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
205921001074	Catalytic domain of Protein Kinases; Region: PKc; cd00180
205921001075	active site
205921001076	ATP binding site [chemical binding]; other site
205921001077	substrate binding site [chemical binding]; other site
205921001078	activation loop (A-loop); other site
205921001079	PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577
205921001080	PASTA domain; Region: PASTA; smart00740
205921001081	PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577
205921001082	Predicted membrane protein [Function unknown]; Region: COG4758
205921001083	Cell wall-active antibiotics response protein (DUF2154); Region: DUF2154; pfam09922
205921001084	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585
205921001085	Histidine kinase; Region: HisKA_3; pfam07730
205921001086	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
205921001087	ATP binding site [chemical binding]; other site
205921001088	Mg2+ binding site [ion binding]; other site
205921001089	G-X-G motif; other site
205921001090	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
205921001091	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
205921001092	active site
205921001093	phosphorylation site [posttranslational modification]
205921001094	intermolecular recognition site; other site
205921001095	dimerization interface [polypeptide binding]; other site
205921001096	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
205921001097	DNA binding residues [nucleotide binding]
205921001098	dimerization interface [polypeptide binding]; other site
205921001099	haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282
205921001100	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
205921001101	active site
205921001102	motif I; other site
205921001103	motif II; other site
205921001104	haloacid dehalogenase-like hydrolase; Region: HAD; cl17202
205921001105	cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317
205921001106	active site
205921001107	general stress protein 13; Validated; Region: PRK08059
205921001108	hypothetical protein; Provisional; Region: PRK07252
205921001109	RNA binding site [nucleotide binding]; other site
205921001110	glycyl-radical enzyme activating protein family; Region: PFLE_PFLC; TIGR02494
205921001111	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
205921001112	FeS/SAM binding site; other site
205921001113	Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349
205921001114	DeoR-like helix-turn-helix domain; Region: HTH_DeoR; cl17531
205921001115	DeoR C terminal sensor domain; Region: DeoRC; pfam00455
205921001116	Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription]; Region: DeoR; COG2390
205921001117	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
205921001118	DNA binding residues [nucleotide binding]
205921001119	Putative sugar-binding domain; Region: Sugar-bind; pfam04198
205921001120	PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_lac; cd00215
205921001121	active site
205921001122	methionine cluster; other site
205921001123	phosphorylation site [posttranslational modification]
205921001124	metal binding site [ion binding]; metal-binding site
205921001125	PTS_IIB_chitobiose_lichenan: subunit IIB of enzyme II (EII) of the N,N-diacetylchitobiose-specific and lichenan-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In these systems, EII is either a lichenan- or an N; Region: PTS_IIB_chitobiose_lichenan; cd05564
205921001126	active site
205921001127	P-loop; other site
205921001128	phosphorylation site [posttranslational modification]
205921001129	Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455
205921001130	cellobiose phosphotransferase system IIC component; Reviewed; Region: celD; PRK09592
205921001131	Pyruvate-formate lyase [Energy production and conversion]; Region: PflD; COG1882
205921001132	Pyruvate formate lyase 2 and related enzymes; Region: PFL2_DhaB_BssA; cd01677
205921001133	dimer interface [polypeptide binding]; other site
205921001134	active site
205921001135	glycine loop; other site
205921001136	Transaldolase-like fructose-6-phosphate aldolases (FSA) found in bacteria and archaea; Region: Transaldolase_FSA; cd00956
205921001137	active site
205921001138	intersubunit interactions; other site
205921001139	catalytic residue [active]
205921001140	Glycerol dehydrogenase and related enzymes [Energy production and conversion]; Region: GldA; COG0371
205921001141	Glycerol dehydrogenases (GlyDH) catalyzes oxidation of glycerol to dihydroxyacetone in glycerol dissmilation; Region: GlyDH; cd08170
205921001142	dimer interface [polypeptide binding]; other site
205921001143	active site
205921001144	metal binding site [ion binding]; metal-binding site
205921001145	Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031
205921001146	CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561
205921001147	dimer interface [polypeptide binding]; other site
205921001148	pyridoxal 5'-phosphate binding site [chemical binding]; other site
205921001149	catalytic residue [active]
205921001150	Uncharacterized conserved protein [Function unknown]; Region: COG1739
205921001151	Uncharacterized protein family UPF0029; Region: UPF0029; pfam01205
205921001152	Domain of unknown function (DUF1949); Region: DUF1949; pfam09186
205921001153	Superfamily II DNA/RNA helicase required for DNA uptake (late competence protein) [DNA replication, recombination, and repair]; Region: comFA; COG4098
205921001154	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
205921001155	ATP binding site [chemical binding]; other site
205921001156	putative Mg++ binding site [ion binding]; other site
205921001157	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
205921001158	nucleotide binding region [chemical binding]; other site
205921001159	ATP-binding site [chemical binding]; other site
205921001160	Predicted amidophosphoribosyltransferases [General function prediction only]; Region: ComFC; COG1040
205921001161	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
205921001162	active site
205921001163	RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY,  is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552
205921001164	30S subunit binding site; other site
205921001165	aspartate kinase; Reviewed; Region: PRK09034
205921001166	AAK_AKiii-YclM-BS: Amino Acid Kinase Superfamily (AAK), AKiii-YclM-BS; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the lysine plus threonine-sensitive aspartokinase isoenzyme AKIII, a monofunctional class enzyme found in...; Region: AAK_AKiii-YclM-BS; cd04245
205921001167	putative catalytic residues [active]
205921001168	putative nucleotide binding site [chemical binding]; other site
205921001169	putative aspartate binding site [chemical binding]; other site
205921001170	ACT domains located C-terminal to the catalytic domain of the lysine plus threonine-sensitive aspartokinase isoenzyme AKIII; Region: ACT_AKiii-YclM-BS_1; cd04911
205921001171	allosteric regulatory residue; other site
205921001172	ACT domains located C-terminal to the catalytic domain of the lysine plus threonine-sensitive aspartokinase isoenzyme AKIII; Region: ACT_AKiii-YclM-BS_2; cd04916
205921001173	Predicted phosphatases [General function prediction only]; Region: Gph; COG0546
205921001174	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
205921001175	motif II; other site
205921001176	enoyl-CoA hydratase; Provisional; Region: PRK07260
205921001177	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
205921001178	substrate binding site [chemical binding]; other site
205921001179	oxyanion hole (OAH) forming residues; other site
205921001180	trimer interface [polypeptide binding]; other site
205921001181	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
205921001182	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
205921001183	putative Zn2+ binding site [ion binding]; other site
205921001184	putative DNA binding site [nucleotide binding]; other site
205921001185	3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352
205921001186	Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830
205921001187	dimer interface [polypeptide binding]; other site
205921001188	active site
205921001189	CoA binding pocket [chemical binding]; other site
205921001190	acyl carrier protein; Provisional; Region: acpP; PRK00982
205921001191	putative enoyl-[acyl-carrier-protein] reductase II; Region: enACPred_II; TIGR03151
205921001192	2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730
205921001193	FMN binding site [chemical binding]; other site
205921001194	substrate binding site [chemical binding]; other site
205921001195	putative catalytic residue [active]
205921001196	(acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331
205921001197	malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128
205921001198	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557
205921001199	beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333
205921001200	NAD(P) binding site [chemical binding]; other site
205921001201	homotetramer interface [polypeptide binding]; other site
205921001202	homodimer interface [polypeptide binding]; other site
205921001203	active site
205921001204	Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834
205921001205	3-oxoacyl-(acyl carrier protein) synthase II; Reviewed; Region: PRK07314
205921001206	dimer interface [polypeptide binding]; other site
205921001207	active site
205921001208	acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated; Region: PRK06302
205921001209	The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850
205921001210	carboxyltransferase (CT) interaction site; other site
205921001211	biotinylation site [posttranslational modification]; other site
205921001212	FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288
205921001213	acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591
205921001214	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
205921001215	Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786
205921001216	Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878
205921001217	acetyl-CoA carboxylase subunit beta; Validated; Region: PRK05654
205921001218	malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682
205921001219	acetyl-CoA carboxylase subunit alpha; Provisional; Region: PRK12319
205921001220	Formate/glycerate dehydrogenases, D-specific 2-hydroxy acid dehydrogenases and related dehydrogenases; Region: FDH_GDH_like; cl17240
205921001221	seryl-tRNA synthetase; Provisional; Region: PRK05431
205921001222	Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403
205921001223	Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770
205921001224	dimer interface [polypeptide binding]; other site
205921001225	active site
205921001226	motif 1; other site
205921001227	motif 2; other site
205921001228	motif 3; other site
205921001229	Predicted O-acyltransferase [General function prediction only]; Region: COG3274
205921001230	Acyltransferase family; Region: Acyl_transf_3; pfam01757
205921001231	Domain of unknown function (DUF956); Region: DUF956; cl01917
205921001232	Phosphotransferase system, mannose/fructose/N-acetylgalactosamine-specific component IID [Carbohydrate transport and metabolism]; Region: ManZ; COG3716
205921001233	PTS system mannose-specific transporter subunit IIC; Provisional; Region: PRK15065
205921001234	PTS system mannose-specific transporter subunits IIAB; Provisional; Region: PRK15088
205921001235	PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006
205921001236	active pocket/dimerization site; other site
205921001237	active site
205921001238	phosphorylation site [posttranslational modification]
205921001239	PTS_IIB, PTS system, Mannose/sorbose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_man; cd00001
205921001240	active site
205921001241	phosphorylation site [posttranslational modification]
205921001242	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
205921001243	haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282
205921001244	active site
205921001245	motif I; other site
205921001246	motif II; other site
205921001247	haloacid dehalogenase-like hydrolase; Region: HAD; cl17202
205921001248	Protein of unknown function (DUF1361); Region: DUF1361; pfam07099
205921001249	Xanthine/uracil/vitamin C permease [Nucleotide transport and    metabolism]; Region: COG2252
205921001250	Predicted ATPase or kinase [General function prediction only]; Region: COG0802
205921001251	pseudaminic acid biosynthesis N-acetyl transferase; Region: PseH; TIGR03585
205921001252	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
205921001253	Coenzyme A binding pocket [chemical binding]; other site
205921001254	Transcriptional regulator [Transcription]; Region: LytR; COG1316
205921001255	HINT (histidine triad nucleotide-binding protein) subgroup: Members of this CD belong to the superfamily of histidine triad hydrolases that act on alpha-phosphate of ribonucleotides. This subgroup includes members from all three forms of cellular life; Region: HINT_subgroup; cd01277
205921001256	HIT family signature motif; other site
205921001257	catalytic residue [active]
205921001258	ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555
205921001259	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
205921001260	Walker A/P-loop; other site
205921001261	ATP binding site [chemical binding]; other site
205921001262	Q-loop/lid; other site
205921001263	ABC transporter signature motif; other site
205921001264	Walker B; other site
205921001265	D-loop; other site
205921001266	H-loop/switch region; other site
205921001267	Bacterial ABC transporter protein EcsB; Region: EcsB; pfam05975
205921001268	Phosphotransferase enzyme family; Region: APH; pfam01636
205921001269	Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120
205921001270	active site
205921001271	ATP binding site [chemical binding]; other site
205921001272	substrate binding site [chemical binding]; other site
205921001273	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
205921001274	S-adenosylmethionine binding site [chemical binding]; other site
205921001275	ribosome maturation protein RimP; Reviewed; Region: PRK00092
205921001276	Bacillus subtilis YxlS-like, C-terminal domain; Region: YlxS_C; cd01734
205921001277	putative oligomer interface [polypeptide binding]; other site
205921001278	putative RNA binding site [nucleotide binding]; other site
205921001279	transcription elongation factor NusA; Provisional; Region: nusA; PRK12327
205921001280	NusA N-terminal domain; Region: NusA_N; pfam08529
205921001281	S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455
205921001282	RNA binding site [nucleotide binding]; other site
205921001283	homodimer interface [polypeptide binding]; other site
205921001284	NusA-like KH domain; Region: KH_5; pfam13184
205921001285	NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134
205921001286	G-X-X-G motif; other site
205921001287	Ylxr homologs; group of conserved hypothetical bacterial proteins of unknown function; structure revealed putative RNA binding cleft; proteins are encoded by an operon that includes other proteins involved in transcription and/or translation; Region: YlxR; cd00279
205921001288	putative RNA binding cleft [nucleotide binding]; other site
205921001289	hypothetical protein; Provisional; Region: PRK07283
205921001290	Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760
205921001291	translation initiation factor IF-2; Region: IF-2; TIGR00487
205921001292	Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760
205921001293	Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887
205921001294	G1 box; other site
205921001295	putative GEF interaction site [polypeptide binding]; other site
205921001296	GTP/Mg2+ binding site [chemical binding]; other site
205921001297	Switch I region; other site
205921001298	G2 box; other site
205921001299	G3 box; other site
205921001300	Switch II region; other site
205921001301	G4 box; other site
205921001302	G5 box; other site
205921001303	This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702
205921001304	Translation-initiation factor 2; Region: IF-2; pfam11987
205921001305	mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692
205921001306	ribosome-binding factor A; Validated; Region: rbfA; PRK00521
205921001307	Esterase/lipase [Lipid metabolism]; Region: Aes; COG0657
205921001308	Protein of unknown function (DUF2424); Region: DUF2424; pfam10340
205921001309	copper transport repressor, CopY/TcrY family; Region: CopY_TcrY; TIGR02698
205921001310	Penicillinase repressor; Region: Pencillinase_R; pfam03965
205921001311	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217
205921001312	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371
205921001313	metal-binding site [ion binding]
205921001314	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
205921001315	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
205921001316	motif II; other site
205921001317	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371
205921001318	metal-binding site [ion binding]
205921001319	Predicted membrane protein [Function unknown]; Region: COG2860
205921001320	UPF0126 domain; Region: UPF0126; pfam03458
205921001321	UPF0126 domain; Region: UPF0126; pfam03458
205921001322	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
205921001323	haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282
205921001324	active site
205921001325	motif I; other site
205921001326	motif II; other site
205921001327	haloacid dehalogenase-like hydrolase; Region: HAD; cl17202
205921001328	DNA polymerase I; Provisional; Region: PRK05755
205921001329	PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859
205921001330	active site
205921001331	metal binding site 1 [ion binding]; metal-binding site
205921001332	putative 5' ssDNA interaction site; other site
205921001333	metal binding site 3; metal-binding site
205921001334	metal binding site 2 [ion binding]; metal-binding site
205921001335	H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898
205921001336	putative DNA binding site [nucleotide binding]; other site
205921001337	putative metal binding site [ion binding]; other site
205921001338	inactive DEDDy 3'-5' exonuclease domain of Bacillus stearothermophilus DNA polymerase I and similar family-A DNA polymerases; Region: DNA_polA_I_Bacillus_like_exo; cd06140
205921001339	Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637
205921001340	active site
205921001341	DNA binding site [nucleotide binding]
205921001342	catalytic site [active]
205921001343	Predicted CoA-binding protein [General function prediction only]; Region: COG1832
205921001344	Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153
205921001345	metal binding site 2 [ion binding]; metal-binding site
205921001346	putative DNA binding helix; other site
205921001347	metal binding site 1 [ion binding]; metal-binding site
205921001348	dimer interface [polypeptide binding]; other site
205921001349	structural Zn2+ binding site [ion binding]; other site
205921001350	YSIRK type signal peptide; Region: YSIRK_signal; cl04650
205921001351	Fibronectin-binding repeat; Region: SSURE; pfam11966
205921001352	Fibronectin-binding repeat; Region: SSURE; pfam11966
205921001353	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
205921001354	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
205921001355	active site
205921001356	phosphorylation site [posttranslational modification]
205921001357	intermolecular recognition site; other site
205921001358	dimerization interface [polypeptide binding]; other site
205921001359	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
205921001360	DNA binding site [nucleotide binding]
205921001361	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
205921001362	HAMP domain; Region: HAMP; pfam00672
205921001363	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
205921001364	dimer interface [polypeptide binding]; other site
205921001365	phosphorylation site [posttranslational modification]
205921001366	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
205921001367	ATP binding site [chemical binding]; other site
205921001368	Mg2+ binding site [ion binding]; other site
205921001369	G-X-G motif; other site
205921001370	Protein of unknown function (DUF975); Region: DUF975; pfam06161
205921001371	queuine tRNA-ribosyltransferase; Provisional; Region: tgt; PRK00112
205921001372	Queuine/archaeosine tRNA-ribosyltransferase [Translation, ribosomal structure and biogenesis]; Region: Tgt; COG0343
205921001373	Zinc finger domain containing protein (CHY type) [Function unknown]; Region: COG4357
205921001374	CHY zinc finger; Region: zf-CHY; pfam05495
205921001375	Uncharacterized conserved protein [General function prediction only]; Region: BioY; COG1268
205921001376	Metal-dependent hydrolases of the beta-lactamase superfamily III [General function prediction only]; Region: ElaC; COG1234
205921001377	Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285
205921001378	nucleoside/Zn binding site; other site
205921001379	dimer interface [polypeptide binding]; other site
205921001380	catalytic motif [active]
205921001381	glucose-6-phosphate isomerase; Provisional; Region: pgi; PRK14097
205921001382	Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015
205921001383	active site
205921001384	dimer interface [polypeptide binding]; other site
205921001385	Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016
205921001386	dimer interface [polypeptide binding]; other site
205921001387	active site
205921001388	5-formyltetrahydrofolate cyclo-ligase family; Region: 5-FTHF_cyc-lig; pfam01812
205921001389	5,10-methenyltetrahydrofolate synthetase; Region: MTHFS_bact; TIGR02727
205921001390	Rhomboid family; Region: Rhomboid; pfam01694
205921001391	Uncharacterized ABC-type transport system, periplasmic component/surface lipoprotein [General function prediction only]; Region: Med; COG1744
205921001392	Periplasmic binding domain of basic membrane lipoprotein, PnrA, in Treponema pallidum and its homologs from other bacteria and Archaea; Region: PBP1_BmpA_PnrA_like; cd06354
205921001393	ligand binding site [chemical binding]; other site
205921001394	Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541
205921001395	dTDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: RfbA; COG1209
205921001396	active site
205921001397	tetramer interface; other site
205921001398	NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094
205921001399	NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210
205921001400	NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479
205921001401	ribonuclease P; Reviewed; Region: rnpA; PRK00499
205921001402	Preprotein translocase subunit YidC [Intracellular trafficking and secretion]; Region: YidC; COG0706
205921001403	membrane protein insertase, YidC/Oxa1 family, C-terminal domain; Region: yidC_oxa1_cterm; TIGR03592
205921001404	Predicted RNA-binding protein [General function prediction only]; Region: Jag; COG1847
205921001405	jag_K homology RNA-binding domain. The KH domain is found in proteins homologous to the Bacillus subtilis protein Jag, which is associated with SpoIIIJ and is necessary for the third stage of sporulation.  The KH motif is a beta-alpha-alpha-beta-beta...; Region: jag_KH; cd02414
205921001406	G-X-X-G motif; other site
205921001407	R3H domain found in proteins homologous to Bacillus subtilus Jag, which is associated with SpoIIIJ. SpoIIIJ is necessary for the third stage of sporulation. The name of the R3H domain comes from the characteristic spacing of the most conserved arginine...; Region: R3H_jag; cd02644
205921001408	RxxxH motif; other site
205921001409	hypothetical protein; Provisional; Region: PRK13662
205921001410	recombination regulator RecX; Provisional; Region: recX; PRK14135
205921001411	SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase [Translation, ribosomal structure and biogenesis]; Region: TrmA; COG2265
205921001412	TRAM domain; Region: TRAM; pfam01938
205921001413	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
205921001414	S-adenosylmethionine binding site [chemical binding]; other site
205921001415	Phosphorylase superfamily; Region: PNP_UDP_1; pfam01048
205921001416	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
205921001417	Acetyltransferases [General function prediction only]; Region: RimI; COG0456
205921001418	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
205921001419	Coenzyme A binding pocket [chemical binding]; other site
205921001420	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
205921001421	Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_d; cd04196
205921001422	Probable Catalytic site; other site
205921001423	ribonucleotide-diphosphate reductase subunit beta; Provisional; Region: nrdF2; PRK13966
205921001424	Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049
205921001425	dimer interface [polypeptide binding]; other site
205921001426	putative radical transfer pathway; other site
205921001427	diiron center [ion binding]; other site
205921001428	tyrosyl radical; other site
205921001429	ribonucleotide reductase stimulatory protein; Reviewed; Region: nrdI; PRK03600
205921001430	ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK07187
205921001431	Ribonucleotide reductase N-terminal; Region: RNR_N; pfam08343
205921001432	Class I ribonucleotide reductase; Region: RNR_I; cd01679
205921001433	active site
205921001434	dimer interface [polypeptide binding]; other site
205921001435	catalytic residues [active]
205921001436	effector binding site; other site
205921001437	R2 peptide binding site; other site
205921001438	Leucine rich repeats (6 copies); Region: LRR_5; pfam13306
205921001439	Leucine rich repeats (6 copies); Region: LRR_5; pfam13306
205921001440	Leucine rich repeats (6 copies); Region: LRR_5; pfam13306
205921001441	Predicted flavin-nucleotide-binding protein structurally related to pyridoxine 5'-phosphate oxidase [General function prediction only]; Region: COG3576
205921001442	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963
205921001443	putative transposase OrfB; Reviewed; Region: PHA02517
205921001444	HTH-like domain; Region: HTH_21; pfam13276
205921001445	Integrase core domain; Region: rve; pfam00665
205921001446	Integrase core domain; Region: rve_2; pfam13333
205921001447	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3708
205921001448	Uncharacterized protein conserved in bacteria (DUF2316); Region: DUF2316; cl01805
205921001449	Uncharacterized protein conserved in bacteria (DUF2316); Region: DUF2316; cl01805
205921001450	Uncharacterized homolog of gamma-carboxymuconolactone decarboxylase subunit [Function unknown]; Region: COG0599
205921001451	Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1917
205921001452	similar to transcriptional regulator, MerR family; identified by similarity to GB:BAB83973.1; match to protein family HMM PF00376
205921001453	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
205921001454	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
205921001455	active site
205921001456	catalytic tetrad [active]
205921001457	Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]; Region: CzcD; COG1230
205921001458	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
205921001459	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
205921001460	YSIRK-targeted surface antigen transcriptional regulator; Region: adjacent_YSIRK; TIGR04094
205921001461	Sigma-70 region 3; Region: Sigma70_r3; pfam04539
205921001462	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
205921001463	Gram-positive signal peptide, YSIRK family; Region: YSIRK_signal; TIGR01168
205921001464	Alpha C protein N terminal; Region: AlphaC_N; pfam08829
205921001465	Rib/alpha-like repeat; Region: Rib; cl07159
205921001466	Rib/alpha-like repeat; Region: Rib; cl07159
205921001467	Rib/alpha-like repeat; Region: Rib; cl07159
205921001468	Rib/alpha-like repeat; Region: Rib; cl07159
205921001469	Rib/alpha-like repeat; Region: Rib; cl07159
205921001470	Rib/alpha-like repeat; Region: Rib; cl07159
205921001471	Rib/alpha-like repeat; Region: Rib; cl07159
205921001472	Rib/alpha-like repeat; Region: Rib; cl07159
205921001473	Rib/alpha-like repeat; Region: Rib; cl07159
205921001474	Gram positive anchor; Region: Gram_pos_anchor; pfam00746
205921001475	Cupin domain; Region: Cupin_2; cl17218
205921001476	Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1917
205921001477	Methyltransferase domain; Region: Methyltransf_31; pfam13847
205921001478	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
205921001479	S-adenosylmethionine binding site [chemical binding]; other site
205921001480	Transcriptional antiterminator [Transcription]; Region: BglG; COG3711
205921001481	PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568
205921001482	active site
205921001483	P-loop; other site
205921001484	phosphorylation site [posttranslational modification]
205921001485	PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211
205921001486	active site
205921001487	phosphorylation site [posttranslational modification]
205921001488	PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211
205921001489	active site
205921001490	phosphorylation site [posttranslational modification]
205921001491	PTS_IIB_galactitol: subunit IIB of enzyme II (EII) of the galactitol-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS).  In this system, EII is a galactitol-specific permease with two cytoplasmic domains (IIA and IIB) and a...; Region: PTS_IIB_galactitol; cd05566
205921001492	active site
205921001493	P-loop; other site
205921001494	phosphorylation site [posttranslational modification]
205921001495	Phosphotransferase system, galactitol-specific IIC component [Carbohydrate transport and metabolism]; Region: GatC; COG3775
205921001496	PTS system sugar-specific permease component; Region: EIIC-GAT; cl04451
205921001497	rhamnulose-1-phosphate aldolase; Provisional; Region: PRK03634
205921001498	intersubunit interface [polypeptide binding]; other site
205921001499	active site
205921001500	Zn2+ binding site [ion binding]; other site
205921001501	PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211
205921001502	active site
205921001503	phosphorylation site [posttranslational modification]
205921001504	Phosphotransferase system, galactitol-specific IIC component [Carbohydrate transport and metabolism]; Region: GatC; COG3775
205921001505	PTS system sugar-specific permease component; Region: EIIC-GAT; cl04451
205921001506	PTS_IIB_galactitol: subunit IIB of enzyme II (EII) of the galactitol-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS).  In this system, EII is a galactitol-specific permease with two cytoplasmic domains (IIA and IIB) and a...; Region: PTS_IIB_galactitol; cd05566
205921001507	active site
205921001508	P-loop; other site
205921001509	phosphorylation site [posttranslational modification]
205921001510	AraC-like ligand binding domain; Region: AraC_binding; pfam02311
205921001511	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
205921001512	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
205921001513	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
205921001514	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
205921001515	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
205921001516	ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209
205921001517	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
205921001518	putative PBP binding loops; other site
205921001519	ABC-ATPase subunit interface; other site
205921001520	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
205921001521	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
205921001522	dimer interface [polypeptide binding]; other site
205921001523	conserved gate region; other site
205921001524	putative PBP binding loops; other site
205921001525	ABC-ATPase subunit interface; other site
205921001526	Alpha-galactosidase [Carbohydrate transport and metabolism]; Region: GalA; COG3345
205921001527	Melibiase; Region: Melibiase; pfam02065
205921001528	galactose-1-phosphate uridylyltransferase; Provisional; Region: PRK05270
205921001529	Galactose-1-phosphate uridyl transferase, N-terminal domain; Region: GalP_UDP_transf; pfam01087
205921001530	Galactose-1-phosphate uridyl transferase, C-terminal domain; Region: GalP_UDP_tr_C; pfam02744
205921001531	UDP-glucose 4-epimerase [Cell envelope biogenesis, outer membrane]; Region: GalE; COG1087
205921001532	UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247
205921001533	NAD binding site [chemical binding]; other site
205921001534	homodimer interface [polypeptide binding]; other site
205921001535	active site
205921001536	substrate binding site [chemical binding]; other site
205921001537	galactose mutarotase_like; Region: galactose_mutarotase_like; cd09019
205921001538	active site
205921001539	catalytic residues [active]
205921001540	DDE superfamily endonuclease; Region: DDE_4_2; pfam13613
205921001541	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3293
205921001542	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
205921001543	aldose 1-epimerase superfamily; Region: Aldose_epim; cl14648
205921001544	catalytic residues [active]
205921001545	Domain of unknown function (DUF1912); Region: DUF1912; pfam08930
205921001546	hypothetical protein; Provisional; Region: PRK07758
205921001547	Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670
205921001548	Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583
205921001549	valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729
205921001550	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
205921001551	active site
205921001552	HIGH motif; other site
205921001553	nucleotide binding site [chemical binding]; other site
205921001554	Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603
205921001555	catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817
205921001556	active site
205921001557	KMSKS motif; other site
205921001558	Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962
205921001559	tRNA binding surface [nucleotide binding]; other site
205921001560	anticodon binding site; other site
205921001561	Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458
205921001562	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
205921001563	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
205921001564	CorA-like Mg2+ transporter protein; Region: CorA; pfam01544
205921001565	uncharacterized bacterial subfamily of the Escherichia coli CorA-Salmonella typhimurium ZntB family; Region: EcCorA_ZntB-like_u2; cd12827
205921001566	Cl binding site [ion binding]; other site
205921001567	oligomer interface [polypeptide binding]; other site
205921001568	Protein of unknown function (DUF419); Region: DUF419; pfam04237
205921001569	Asparagine synthetase (aspartate-ammonia ligase) (AsnA) catalyses the conversion of L-aspartate to L-asparagine in the presence of ATP and ammonia.  AsnA is a homodimeric enzyme which is structurally similiar to the catalytic core domain of class II...; Region: AsnA; cd00645
205921001570	dimer interface [polypeptide binding]; other site
205921001571	active site
205921001572	TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947
205921001573	catalytic residues [active]
205921001574	N6-adenine-specific methylase [DNA replication, recombination, and repair]; Region: COG0742
205921001575	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
205921001576	S-adenosylmethionine binding site [chemical binding]; other site
205921001577	phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168
205921001578	Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163
205921001579	active site
205921001580	(T/H)XGH motif; other site
205921001581	Predicted secreted protein containing a PDZ domain [Signal transduction mechanisms]; Region: SdrC; COG3480
205921001582	PDZ domain, also called DHR (Dlg homologous region) or GLGF (after a conserved sequence motif). Many PDZ domains bind C-terminal polypeptides, though binding to internal (non-C-terminal) polypeptides and even to lipids has been demonstrated; Region: PDZ; cl00117
205921001583	protein binding site [polypeptide binding]; other site
205921001584	Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362
205921001585	Escherichia coli UshA-like family, N-terminal metallophosphatase domain; Region: MPP_UshA_N_like; cd00845
205921001586	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
205921001587	active site
205921001588	metal binding site [ion binding]; metal-binding site
205921001589	5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872
205921001590	Protein of unknown function (DUF1027); Region: DUF1027; cl09961
205921001591	ribosomal RNA large subunit methyltransferase N; Provisional; Region: PRK14455
205921001592	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
205921001593	FeS/SAM binding site; other site
205921001594	VanZ like family; Region: VanZ; pfam04892
205921001595	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
205921001596	putative multidrug transporter membrane\ATP-binding components; Provisional; Region: PRK10789
205921001597	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
205921001598	Walker A/P-loop; other site
205921001599	ATP binding site [chemical binding]; other site
205921001600	Q-loop/lid; other site
205921001601	ABC transporter signature motif; other site
205921001602	Walker B; other site
205921001603	D-loop; other site
205921001604	H-loop/switch region; other site
205921001605	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
205921001606	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
205921001607	ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254
205921001608	Walker A/P-loop; other site
205921001609	ATP binding site [chemical binding]; other site
205921001610	Q-loop/lid; other site
205921001611	ABC transporter signature motif; other site
205921001612	Walker B; other site
205921001613	D-loop; other site
205921001614	H-loop/switch region; other site
205921001615	Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743
205921001616	Glutamine amidotransferase class-I; Region: GATase; pfam00117
205921001617	glutamine binding [chemical binding]; other site
205921001618	catalytic triad [active]
205921001619	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3666
205921001620	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
205921001621	Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751
205921001622	Uncharacterized conserved protein [General function prediction only]; Region: BioY; COG1268
205921001623	biotin synthase; Region: bioB; TIGR00433
205921001624	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
205921001625	FeS/SAM binding site; other site
205921001626	Biotin and Thiamin Synthesis associated domain; Region: BATS; pfam06968
205921001627	Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751
205921001628	acetyl-CoA acetyltransferases; Region: AcCoA-C-Actrans; TIGR01930
205921001629	dimer interface [polypeptide binding]; other site
205921001630	active site
205921001631	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
205921001632	Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318
205921001633	active site
205921001634	CoA binding site [chemical binding]; other site
205921001635	AMP binding site [chemical binding]; other site
205921001636	Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177
205921001637	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056
205921001638	minor groove reading motif; other site
205921001639	helix-hairpin-helix signature motif; other site
205921001640	substrate binding pocket [chemical binding]; other site
205921001641	active site
205921001642	Type IV leader peptidase family; Region: Peptidase_A24; pfam01478
205921001643	Bacterial protein of unknown function (DUF910); Region: DUF910; pfam06014
205921001644	ROK family protein (putative glucokinase); Region: ROK_glcA_fam; TIGR00744
205921001645	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012
205921001646	nucleotide binding site [chemical binding]; other site
205921001647	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158
205921001648	active site residue [active]
205921001649	Predicted membrane GTPase involved in stress response [Signal transduction mechanisms]; Region: TypA; COG1217
205921001650	Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891
205921001651	G1 box; other site
205921001652	putative GEF interaction site [polypeptide binding]; other site
205921001653	GTP/Mg2+ binding site [chemical binding]; other site
205921001654	Switch I region; other site
205921001655	G2 box; other site
205921001656	G3 box; other site
205921001657	Switch II region; other site
205921001658	G4 box; other site
205921001659	G5 box; other site
205921001660	BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu.  BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691
205921001661	BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants.  BipA is a highly...; Region: BipA_TypA_C; cd03710
205921001662	Protein of unknown function (DUF3165); Region: DUF3165; pfam11364
205921001663	UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK02472
205921001664	Alanine dehydrogenase/PNT, C-terminal domain; Region: AlaDh_PNT_C; smart01002
205921001665	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
205921001666	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
205921001667	undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726
205921001668	MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785
205921001669	homodimer interface [polypeptide binding]; other site
205921001670	active site
205921001671	POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478
205921001672	Cell division protein FtsQ; Region: FtsQ; pfam03799
205921001673	Cell division ATPase FtsA [Cell division and chromosome partitioning]; Region: ftsA; COG0849
205921001674	Cell division protein FtsA; Region: FtsA; smart00842
205921001675	Cell division protein FtsA; Region: FtsA; pfam14450
205921001676	Domain of unknown function (DUF3484); Region: DUF3484; pfam11983
205921001677	cell division protein FtsZ; Validated; Region: PRK09330
205921001678	FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes.  FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201
205921001679	nucleotide binding site [chemical binding]; other site
205921001680	SulA interaction site; other site
205921001681	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, YBL036c-like proteins; Region: PLPDE_III_YBL036c_like; cd00635
205921001682	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
205921001683	catalytic residue [active]
205921001684	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1799
205921001685	YGGT family; Region: YGGT; pfam02325
205921001686	Uncharacterized conserved protein, contains S4-like domain [Function unknown]; Region: COG2302
205921001687	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
205921001688	RNA binding surface [nucleotide binding]; other site
205921001689	DivIVA protein; Region: DivIVA; pfam05103
205921001690	DivIVA domain; Region: DivI1A_domain; TIGR03544
205921001691	isoleucyl-tRNA synthetase; Provisional; Region: ileS; PRK13804
205921001692	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
205921001693	active site
205921001694	HIGH motif; other site
205921001695	nucleotide binding site [chemical binding]; other site
205921001696	catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818
205921001697	active site
205921001698	KMSKS motif; other site
205921001699	Anticodon-binding domain of bacterial and eukaryotic mitochondrial isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_BEm; cd07960
205921001700	tRNA binding surface [nucleotide binding]; other site
205921001701	anticodon binding site; other site
205921001702	Domain of unknown function (DUF1827); Region: DUF1827; pfam08860
205921001703	Contains a crystal structure of the Nudix hydrolase from Enterococcus faecalis, which has an unknown function. In general, members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes...; Region: Nudix_Hydrolase_25; cd04684
205921001704	nudix motif; other site
205921001705	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
205921001706	ATPases associated with a variety of cellular activities; Region: AAA; smart00382
205921001707	Walker A motif; other site
205921001708	ATP binding site [chemical binding]; other site
205921001709	Walker B motif; other site
205921001710	arginine finger; other site
205921001711	UvrB/uvrC motif; Region: UVR; pfam02151
205921001712	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
205921001713	ATPases associated with a variety of cellular activities; Region: AAA; smart00382
205921001714	Walker A motif; other site
205921001715	ATP binding site [chemical binding]; other site
205921001716	Walker B motif; other site
205921001717	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431
205921001718	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4703
205921001719	ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215
205921001720	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
205921001721	dimer interface [polypeptide binding]; other site
205921001722	conserved gate region; other site
205921001723	putative PBP binding loops; other site
205921001724	ABC-ATPase subunit interface; other site
205921001725	ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126
205921001726	ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262
205921001727	Walker A/P-loop; other site
205921001728	ATP binding site [chemical binding]; other site
205921001729	Q-loop/lid; other site
205921001730	ABC transporter signature motif; other site
205921001731	Walker B; other site
205921001732	D-loop; other site
205921001733	H-loop/switch region; other site
205921001734	phosphoglucomutase-2-like protein; Provisional; Region: PTZ00150
205921001735	This CD includes PGM2 (phosphoglucomutase 2) and PGM2L1 (phosphoglucomutase 2-like 1). The mammalian PGM2 is thought to be a phosphopentomutase that catalyzes the conversion of the nucleoside breakdown products, ribose-1-phosphate and...; Region: PGM2; cd05799
205921001736	active site
205921001737	substrate binding site [chemical binding]; other site
205921001738	metal binding site [ion binding]; metal-binding site
205921001739	bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK14179
205921001740	Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763
205921001741	NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080
205921001742	homodimer interface [polypeptide binding]; other site
205921001743	NADP binding site [chemical binding]; other site
205921001744	substrate binding site [chemical binding]; other site
205921001745	B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171
205921001746	putative substrate binding site [chemical binding]; other site
205921001747	putative ATP binding site [chemical binding]; other site
205921001748	exodeoxyribonuclease VII large subunit; Reviewed; Region: xseA; PRK00286
205921001749	ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489
205921001750	generic binding surface II; other site
205921001751	generic binding surface I; other site
205921001752	exodeoxyribonuclease VII small subunit; Provisional; Region: PRK00977
205921001753	Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142
205921001754	Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685
205921001755	substrate binding pocket [chemical binding]; other site
205921001756	chain length determination region; other site
205921001757	substrate-Mg2+ binding site; other site
205921001758	catalytic residues [active]
205921001759	aspartate-rich region 1; other site
205921001760	active site lid residues [active]
205921001761	aspartate-rich region 2; other site
205921001762	Predicted rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: COG1189
205921001763	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
205921001764	RNA binding surface [nucleotide binding]; other site
205921001765	FtsJ-like methyltransferase; Region: FtsJ; pfam01728
205921001766	Arginine repressor [Transcription]; Region: ArgR; COG1438
205921001767	Arginine repressor, DNA binding domain; Region: Arg_repressor; pfam01316
205921001768	Arginine repressor, C-terminal domain; Region: Arg_repressor_C; pfam02863
205921001769	ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: RecN; COG0497
205921001770	ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241
205921001771	Walker A/P-loop; other site
205921001772	ATP binding site [chemical binding]; other site
205921001773	Q-loop/lid; other site
205921001774	ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241
205921001775	ABC transporter signature motif; other site
205921001776	Walker B; other site
205921001777	D-loop; other site
205921001778	H-loop/switch region; other site
205921001779	EDD domain protein, DegV family; Region: DegV; TIGR00762
205921001780	Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645
205921001781	Members of the SGNH-hydrolase superfamily, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase_YpmR_like; cd04506
205921001782	active site
205921001783	catalytic triad [active]
205921001784	oxyanion hole [active]
205921001785	Uncharacterized protein conserved in bacteria (DUF2140); Region: DUF2140; pfam09911
205921001786	Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591
205921001787	IHF dimer interface [polypeptide binding]; other site
205921001788	IHF - DNA interface [nucleotide binding]; other site
205921001789	site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236
205921001790	Tn1545-related conjugative transposon integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes bacterial (gram positive) and phage integrases, including those similar to Tn1545, Tn5252, and...; Region: INT_Tn1545_C; cd01199
205921001791	Int/Topo IB signature motif; other site
205921001792	TM2 domain; Region: TM2; pfam05154
205921001793	Domain of unknown function (DUF955); Region: DUF955; pfam06114
205921001794	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
205921001795	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
205921001796	salt bridge; other site
205921001797	non-specific DNA binding site [nucleotide binding]; other site
205921001798	sequence-specific DNA binding site [nucleotide binding]; other site
205921001799	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
205921001800	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
205921001801	non-specific DNA binding site [nucleotide binding]; other site
205921001802	salt bridge; other site
205921001803	sequence-specific DNA binding site [nucleotide binding]; other site
205921001804	phage nucleotide-binding protein; Region: phage_P_loop; TIGR01618
205921001805	AAA domain; Region: AAA_24; pfam13479
205921001806	DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061
205921001807	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
205921001808	ATP binding site [chemical binding]; other site
205921001809	putative Mg++ binding site [ion binding]; other site
205921001810	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
205921001811	nucleotide binding region [chemical binding]; other site
205921001812	ATP-binding site [chemical binding]; other site
205921001813	Uncharacterized protein family UPF0547; Region: UPF0547; pfam10571
205921001814	Protein of unknown function (DUF669); Region: DUF669; pfam05037
205921001815	Prim_Pol: Primase-polymerase (primpol) domain of the type found in bifunctional replicases from archaeal plasmids, including ORF904 protein of the crenarchaeal plasmid pRN1 from Sulfolobus islandicus (pRN1 primpol). These primpol domains belong to the...; Region: Prim_Pol; cd04859
205921001816	polymerase nucleotide-binding site; other site
205921001817	DNA-binding residues [nucleotide binding]; DNA binding site
205921001818	nucleotide binding site [chemical binding]; other site
205921001819	primase nucleotide-binding site [nucleotide binding]; other site
205921001820	Primase C terminal 1 (PriCT-1); Region: PriCT_1; smart00942
205921001821	VRR-NUC domain; Region: VRR_NUC; pfam08774
205921001822	Domain of Unknown Function (DUF1599); Region: DUF1599; pfam07659
205921001823	Protein of unknown function (DUF1642); Region: DUF1642; pfam07852
205921001824	Protein of unknown function (DUF1492); Region: DUF1492; pfam07374
205921001825	Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403
205921001826	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085
205921001827	active site
205921001828	Life-span regulatory factor; Region: Ecl1; pfam12855
205921001829	Phage portal protein, SPP1 Gp6-like; Region: Phage_prot_Gp6; pfam05133
205921001830	Phage Terminase; Region: Terminase_1; pfam03354
205921001831	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251
205921001832	ATP binding site [chemical binding]; other site
205921001833	putative Mg++ binding site [ion binding]; other site
205921001834	Domain of unknown function (DUF4355); Region: DUF4355; pfam14265
205921001835	Phage capsid family; Region: Phage_capsid; pfam05065
205921001836	HeH/LEM domain; Region: HeH; pfam12949
205921001837	Phage protein Gp19/Gp15/Gp42; Region: Phage_Gp19; pfam09355
205921001838	Phage-related protein [Function unknown]; Region: COG5412
205921001839	Phage tail protein; Region: Sipho_tail; pfam05709
205921001840	Phage tail protein; Region: Sipho_tail; cl17486
205921001841	Mannosyl-glycoprotein endo-beta-N-acetylglucosaminidase; Region: Glucosaminidase; cl17361
205921001842	Prophage endopeptidase tail; Region: Prophage_tail; cl12123
205921001843	Collagen triple helix repeat (20 copies); Region: Collagen; pfam01391
205921001844	Siphovirus protein of unknown function (DUF859); Region: DUF859; pfam05895
205921001845	Siphovirus protein of unknown function (DUF859); Region: DUF859; pfam05895
205921001846	Protein of unknown function (DUF1366); Region: DUF1366; pfam07104
205921001847	Small integral membrane protein [Function unknown]; Region: COG5546
205921001848	CHAP domain; Region: CHAP; pfam05257
205921001849	Cpl-1 lysin (also known as Cpl-9 lysozyme / muramidase) is a bacterial cell wall endolysin encoded by the pneumococcal bacteriophage Cp-1, which cleaves the glycosidic N-acetylmuramoyl-(beta1,4)-N-acetylglucosamine bonds of the pneumococcal glycan chain; Region: GH25_Cpl1-like; cd06415
205921001850	Glycosyl hydrolases family 25; Region: Glyco_hydro_25; pfam01183
205921001851	active site
205921001852	dihydroorotate dehydrogenase (subfamily 1) family protein; Region: pyrD_sub1_fam; TIGR01037
205921001853	Dihydroorotate dehydrogenase (DHOD) class 1A FMN-binding domain. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine...; Region: DHOD_1A_like; cd04741
205921001854	active site
205921001855	FMN binding site [chemical binding]; other site
205921001856	substrate binding site [chemical binding]; other site
205921001857	catalytic residues [active]
205921001858	homodimer interface [polypeptide binding]; other site
205921001859	FemAB family; Region: FemAB; pfam02388
205921001860	FemAB family; Region: FemAB; pfam02388
205921001861	FemAB family; Region: FemAB; pfam02388
205921001862	Acetyltransferase (GNAT) domain; Region: Acetyltransf_6; pfam13480
205921001863	sugar phosphate phosphatase; Provisional; Region: PRK10513
205921001864	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
205921001865	active site
205921001866	motif I; other site
205921001867	motif II; other site
205921001868	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cl17915
205921001869	haloacid dehalogenase-like hydrolase; Region: HAD; cl17202
205921001870	HD superfamily phosphohydrolases [General function prediction only]; Region: COG1078
205921001871	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
205921001872	Zn2+ binding site [ion binding]; other site
205921001873	Mg2+ binding site [ion binding]; other site
205921001874	Domain of unknown function (DUF1934); Region: DUF1934; pfam09148
205921001875	Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; pfam00690
205921001876	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474
205921001877	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
205921001878	Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246
205921001879	haloacid dehalogenase-like hydrolase; Region: HAD; pfam12710
205921001880	Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689
205921001881	Firmicute fructose-1,6-bisphosphatase; Region: FBPase_2; pfam06874
205921001882	epoxyqueuosine reductase; Region: TIGR00276
205921001883	Domain of unknown function (DUF1730); Region: DUF1730; pfam08331
205921001884	peptide chain release factor 2; Validated; Region: prfB; PRK00578
205921001885	This domain is found in peptide chain release factors; Region: PCRF; smart00937
205921001886	RF-1 domain; Region: RF-1; pfam00472
205921001887	Predicted ATPase involved in cell division [Cell division and chromosome partitioning]; Region: FtsE; COG2884
205921001888	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
205921001889	Walker A/P-loop; other site
205921001890	ATP binding site [chemical binding]; other site
205921001891	Q-loop/lid; other site
205921001892	ABC transporter signature motif; other site
205921001893	Walker B; other site
205921001894	D-loop; other site
205921001895	H-loop/switch region; other site
205921001896	Cell division protein [Cell division and chromosome partitioning]; Region: FtsX; COG2177
205921001897	cell division ABC transporter subunit FtsX; Provisional; Region: ftsX; PRK11026
205921001898	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3666
205921001899	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
205921001900	Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751
205921001901	Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695
205921001902	Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491
205921001903	acetoin reductase; Validated; Region: PRK08643
205921001904	meso-2,3-butanediol dehydrogenase-like, classical (c) SDRs; Region: meso-BDH-like_SDR_c; cd05366
205921001905	NAD binding site [chemical binding]; other site
205921001906	homotetramer interface [polypeptide binding]; other site
205921001907	homodimer interface [polypeptide binding]; other site
205921001908	active site
205921001909	substrate binding site [chemical binding]; other site
205921001910	bifunctional ATP-dependent DNA helicase/DNA polymerase III subunit epsilon; Validated; Region: PRK07246
205921001911	DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127
205921001912	active site
205921001913	catalytic site [active]
205921001914	substrate binding site [chemical binding]; other site
205921001915	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
205921001916	ATP binding site [chemical binding]; other site
205921001917	Helicase C-terminal domain; Region: Helicase_C_2; pfam13307
205921001918	aspartate aminotransferase; Provisional; Region: PRK05764
205921001919	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
205921001920	pyridoxal 5'-phosphate binding site [chemical binding]; other site
205921001921	homodimer interface [polypeptide binding]; other site
205921001922	catalytic residue [active]
205921001923	asparaginyl-tRNA synthetase; Validated; Region: asnC; PRK03932
205921001924	AsnRS_cyto_like_N: N-terminal, anticodon recognition domain of the type found in human and Saccharomyces cerevisiae cytoplasmic asparaginyl-tRNA synthetase (AsnRS), in Brugia malayai AsnRs and, in various putative bacterial AsnRSs.  This domain is a...; Region: AsnRS_cyto_like_N; cd04323
205921001925	putative dimer interface [polypeptide binding]; other site
205921001926	putative anticodon binding site; other site
205921001927	Asx tRNA synthetase (AspRS/AsnRS) class II core domain.  Assignment to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs in the core domain. This family includes AsnRS as well as...; Region: AsxRS_core; cd00776
205921001928	homodimer interface [polypeptide binding]; other site
205921001929	motif 1; other site
205921001930	motif 2; other site
205921001931	active site
205921001932	motif 3; other site
205921001933	NH_3: A subgroup of nucleoside hydrolases. This group contains eukaryotic and bacterial proteins similar to nucleoside hydrolases. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the respective base. These enzymes...; Region: nuc_hydro_3; cd02653
205921001934	active site
205921001935	OsmC-like protein; Region: OsmC; cl00767
205921001936	glmZ(sRNA)-inactivating NTPase; Provisional; Region: PRK05416
205921001937	Family of CofD-like proteins and proteins related to YvcK; Region: CofD_YvcK; cl00425
205921001938	dimer interface [polypeptide binding]; other site
205921001939	phosphate binding site [ion binding]; other site
205921001940	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1481
205921001941	Sporulation Regulator WhiA N terminal; Region: WhiA_N; pfam10298
205921001942	Peptidase family C69; Region: Peptidase_C69; pfam03577
205921001943	ABC-type metal ion transport system, periplasmic component/surface adhesin [Inorganic ion transport and metabolism]; Region: LraI; COG0803
205921001944	Metal binding protein AcdA.  These proteins have been shown to function in the ABC uptake of Zn2+ and Mn2+ and in competence for genetic transformation and adhesion. The AcdA proteins belong to the TroA superfamily of helical backbone metal receptor...; Region: AdcA; cd01017
205921001945	metal binding site [ion binding]; metal-binding site
205921001946	YodA lipocalin-like domain; Region: YodA; pfam09223
205921001947	50S ribosomal protein L31 type B; Reviewed; Region: rpmE2; PRK01678
205921001948	Exopolyphosphatase-related proteins [General function prediction only]; Region: COG0618
205921001949	DHH family; Region: DHH; pfam01368
205921001950	DHHA1 domain; Region: DHHA1; pfam02272
205921001951	Adenosine deaminase (ADA) is a monomeric zinc dependent enzyme which catalyzes the irreversible hydrolytic deamination of both adenosine, as well as desoxyadenosine, to ammonia and inosine or desoxyinosine, respectively. ADA plays an important role in...; Region: ADA; cd01320
205921001952	Adenosine deaminase [Nucleotide transport and metabolism]; Region: Add; COG1816
205921001953	active site
205921001954	purine riboside binding site [chemical binding]; other site
205921001955	flavodoxin; Validated; Region: PRK07308
205921001956	hypothetical protein; Provisional; Region: PRK07248
205921001957	Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038
205921001958	ClC sycA-like chloride channel proteins. This ClC family presents in bacteria, where it facilitates acid resistance in acidic soil. Mutation of this gene (sycA) in Rhizobium tropici CIAT899 causes serious deficiencies in nodule development, nodulation...; Region: ClC_sycA_like; cd03682
205921001959	putative Cl- selectivity filter; other site
205921001960	putative pore gating glutamate residue; other site
205921001961	50S ribosomal protein L19; Provisional; Region: rplS; PRK05338
205921001962	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963
205921001963	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963
205921001964	Helix-turn-helix domain; Region: HTH_28; pfam13518
205921001965	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
205921001966	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
205921001967	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
205921001968	Walker A/P-loop; other site
205921001969	ATP binding site [chemical binding]; other site
205921001970	Q-loop/lid; other site
205921001971	ABC transporter signature motif; other site
205921001972	Walker B; other site
205921001973	D-loop; other site
205921001974	H-loop/switch region; other site
205921001975	ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]; Region: LolE; COG4591
205921001976	FtsX-like permease family; Region: FtsX; pfam02687
205921001977	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
205921001978	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
205921001979	active site
205921001980	phosphorylation site [posttranslational modification]
205921001981	intermolecular recognition site; other site
205921001982	dimerization interface [polypeptide binding]; other site
205921001983	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
205921001984	DNA binding site [nucleotide binding]
205921001985	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054
205921001986	dimerization interface [polypeptide binding]; other site
205921001987	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
205921001988	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
205921001989	dimer interface [polypeptide binding]; other site
205921001990	phosphorylation site [posttranslational modification]
205921001991	Histidine kinase-like ATPases; Region: HATPase_c; smart00387
205921001992	ATP binding site [chemical binding]; other site
205921001993	Mg2+ binding site [ion binding]; other site
205921001994	G-X-G motif; other site
205921001995	Integrase core domain; Region: rve; pfam00665
205921001996	Integrase core domain; Region: rve_3; cl15866
205921001997	CsbD-like; Region: CsbD; pfam05532
205921001998	rod shape-determining protein RodA; Region: rodA_shape; TIGR02210
205921001999	haloacid dehalogenase superfamily, subfamily IA, variant 1 with third motif having Dx(3-4)D or Dx(3-4)E; Region: HAD-SF-IA-v1; TIGR01549
205921002000	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
205921002001	motif II; other site
205921002002	DNA gyrase subunit B; Validated; Region: gyrB; PRK05644
205921002003	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
205921002004	Mg2+ binding site [ion binding]; other site
205921002005	G-X-G motif; other site
205921002006	TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822
205921002007	anchoring element; other site
205921002008	dimer interface [polypeptide binding]; other site
205921002009	ATP binding site [chemical binding]; other site
205921002010	TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366
205921002011	active site
205921002012	putative metal-binding site [ion binding]; other site
205921002013	DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986
205921002014	septation ring formation regulator EzrA; Provisional; Region: PRK04778
205921002015	haloacid dehalogenase-like hydrolase; Region: HAD; cl17202
205921002016	phosphoserine phosphatase SerB; Region: serB; TIGR00338
205921002017	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
205921002018	motif II; other site
205921002019	NUDIX domain; Region: NUDIX; pfam00293
205921002020	nudix motif; other site
205921002021	Protein of unknown function (DUF1694); Region: DUF1694; pfam07997
205921002022	enolase; Provisional; Region: eno; PRK00077
205921002023	Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313
205921002024	dimer interface [polypeptide binding]; other site
205921002025	metal binding site [ion binding]; metal-binding site
205921002026	substrate binding pocket [chemical binding]; other site
205921002027	DNA/RNA non-specific endonuclease; Region: Endonuclea_NS_2; cl17626
205921002028	DNA/RNA non-specific endonuclease; Region: Endonuclease_NS; smart00892
205921002029	3-phosphoshikimate 1-carboxyvinyltransferase; Provisional; Region: PRK02427
205921002030	EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556
205921002031	hinge; other site
205921002032	active site
205921002033	shikimate kinase; Reviewed; Region: aroK; PRK00131
205921002034	Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464
205921002035	ADP binding site [chemical binding]; other site
205921002036	magnesium binding site [ion binding]; other site
205921002037	putative shikimate binding site; other site
205921002038	Transcriptional regulator [Transcription]; Region: LytR; COG1316
205921002039	SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase [Translation, ribosomal structure and biogenesis]; Region: TrmA; COG2265
205921002040	TRAM domain; Region: TRAM; cl01282
205921002041	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
205921002042	S-adenosylmethionine binding site [chemical binding]; other site
205921002043	Uncharacterized conserved protein [Function unknown]; Region: COG4283
205921002044	probable dihydroxyacetone kinase regulator; Region: DHAK_reg; TIGR02366
205921002045	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
205921002046	Gram-positive signal peptide, YSIRK family; Region: YSIRK_signal; TIGR01168
205921002047	G5 domain; Region: G5; pfam07501
205921002048	Collagen triple helix repeat (20 copies); Region: Collagen; pfam01391
205921002049	Domain of unknown function (DUF955); Region: DUF955; cl01076
205921002050	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
205921002051	non-specific DNA binding site [nucleotide binding]; other site
205921002052	salt bridge; other site
205921002053	sequence-specific DNA binding site [nucleotide binding]; other site
205921002054	Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_A; cd08642
205921002055	active site
205921002056	DNA binding site [nucleotide binding]
205921002057	catalytic site [active]
205921002058	Protein of unknown function (DUF2815); Region: DUF2815; pfam10991
205921002059	Protein of unknown function (DUF2800); Region: DUF2800; pfam10926
205921002060	Primase C terminal 1 (PriCT-1); Region: PriCT_1; smart00942
205921002061	D5 N terminal like; Region: D5_N; pfam08706
205921002062	phage/plasmid primase, P4 family, C-terminal domain; Region: primase_Cterm; TIGR01613
205921002063	VRR-NUC domain; Region: VRR_NUC; pfam08774
205921002064	Superfamily II DNA/RNA helicases, SNF2 family [Transcription / DNA replication, recombination, and repair]; Region: HepA; COG0553
205921002065	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
205921002066	ATP binding site [chemical binding]; other site
205921002067	putative Mg++ binding site [ion binding]; other site
205921002068	NAD(P) binding domain of amino acid dehydrogenase-like proteins; Region: NAD_bind_amino_acid_DH; cl17226
205921002069	NAD(P) binding pocket [chemical binding]; other site
205921002070	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cl17351
205921002071	nucleotide binding region [chemical binding]; other site
205921002072	ATP-binding site [chemical binding]; other site
205921002073	S-adenosylmethionine synthetase; Validated; Region: PRK05250
205921002074	S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438
205921002075	S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772
205921002076	S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773
205921002077	Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403
205921002078	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085
205921002079	active site
205921002080	Stage 0 sporulation protein J (antagonist of Soj) containing ParB-like nuclease domain [Transcription]; Region: Spo0J; COG1475
205921002081	ParB-like nuclease domain; Region: ParB; smart00470
205921002082	DNA modification methylase [DNA replication, recombination, and repair]; Region: COG0863
205921002083	DNA methylase; Region: N6_N4_Mtase; pfam01555
205921002084	Site-specific DNA methylase [DNA replication, recombination, and repair]; Region: Dcm; COG0270
205921002085	Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315
205921002086	cofactor binding site; other site
205921002087	DNA binding site [nucleotide binding]
205921002088	substrate interaction site [chemical binding]; other site
205921002089	Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315
205921002090	Domain of unknown function (DUF4314); Region: DUF4314; pfam14192
205921002091	Phage terminase, small subunit; Region: Terminase_4; pfam05119
205921002092	Phage terminase-like protein, large subunit [General function prediction only]; Region: COG4626
205921002093	RelB antitoxin; Region: RelB; pfam04221
205921002094	addiction module toxin, RelE/StbE family; Region: RelE_StbE; TIGR02385
205921002095	Phage-related protein [Function unknown]; Region: COG4695
205921002096	Phage portal protein; Region: Phage_portal; pfam04860
205921002097	Clp protease; Region: CLP_protease; pfam00574
205921002098	Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_1; cd07016
205921002099	oligomer interface [polypeptide binding]; other site
205921002100	active site residues [active]
205921002101	phage major capsid protein, HK97 family; Region: major_cap_HK97; TIGR01554
205921002102	Phage capsid family; Region: Phage_capsid; pfam05065
205921002103	Head-Tail Connector Protein gp6 of Bacteriophage HK97 and similar proteins; Region: gp6; cd08054
205921002104	oligomerization interface [polypeptide binding]; other site
205921002105	Phage head-tail joining protein; Region: Phage_H_T_join; pfam05521
205921002106	phage major tail protein, phi13 family; Region: maj_tail_phi13; TIGR01603
205921002107	phage tail tape measure protein, TP901 family, core region; Region: tape_meas_TP901; TIGR01760
205921002108	Phage-related protein [Function unknown]; Region: COG5412
205921002109	Phage-related protein [Function unknown]; Region: COG4722
205921002110	Prophage endopeptidase tail; Region: Prophage_tail; cl12123
205921002111	Siphovirus protein of unknown function (DUF859); Region: DUF859; pfam05895
205921002112	Holin family; Region: Phage_holin_4; pfam05105
205921002113	Muramidase (flagellum-specific) [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FlgJ; COG1705
205921002114	N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696
205921002115	active site
205921002116	metal binding site [ion binding]; metal-binding site
205921002117	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
205921002118	Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961
205921002119	Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338
205921002120	catalytic residues [active]
205921002121	catalytic nucleophile [active]
205921002122	Recombinase; Region: Recombinase; pfam07508
205921002123	Recombinase zinc beta ribbon domain; Region: Zn_ribbon_recom; pfam13408
205921002124	Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961
205921002125	Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338
205921002126	catalytic residues [active]
205921002127	catalytic nucleophile [active]
205921002128	Recombinase; Region: Recombinase; pfam07508
205921002129	Recombinase zinc beta ribbon domain; Region: Zn_ribbon_recom; pfam13408
205921002130	Serine/threonine protein kinase [General function prediction only / Signal transduction mechanisms / Transcription / DNA replication, recombination, and repair]; Region: SPS1; COG0515
205921002131	Catalytic domain of Protein Kinases; Region: PKc; cd00180
205921002132	active site
205921002133	ATP binding site [chemical binding]; other site
205921002134	substrate binding site [chemical binding]; other site
205921002135	activation loop (A-loop); other site
205921002136	acid phosphatase/phosphotransferase; Provisional; Region: aphA; PRK11009
205921002137	Protein of unknown function (DUF1706); Region: DUF1706; pfam08020
205921002138	YSIRK type signal peptide; Region: YSIRK_signal; pfam04650
205921002139	HTH-like domain; Region: HTH_21; pfam13276
205921002140	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801
205921002141	Integrase core domain; Region: rve; pfam00665
205921002142	Integrase core domain; Region: rve_3; pfam13683
205921002143	Transposase; Region: HTH_Tnp_1; pfam01527
205921002144	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963
205921002145	Heat shock protein 33 (Hsp33):  Cytosolic protein that acts as a molecular chaperone under oxidative conditions.  In normal (reducing) cytosolic conditions, four conserved Cys residues are coordinated by a Zn ion. Under oxidative stress (such as heat...; Region: Hsp33; cl00236
205921002146	YSIRK-targeted surface antigen transcriptional regulator; Region: adjacent_YSIRK; TIGR04094
205921002147	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
205921002148	fimbrial isopeptide formation D2 domain; Region: RrgB_K2N_iso_D2; TIGR04226
205921002149	Cna protein B-type domain; Region: Cna_B; pfam05738
205921002150	Sortase C (SrtC) or subfamily-3 sortases are membrane cysteine transpeptidases found in Gram-positive bacteria that anchor surface proteins to peptidoglycans of the bacterial cell wall envelope. This involves a transpeptidation reaction in which the...; Region: Sortase_C_3; cd05827
205921002151	active site
205921002152	catalytic site [active]
205921002153	Sortase C (SrtC) or subfamily-3 sortases are membrane cysteine transpeptidases found in Gram-positive bacteria that anchor surface proteins to peptidoglycans of the bacterial cell wall envelope. This involves a transpeptidation reaction in which the...; Region: Sortase_C_3; cd05827
205921002154	active site
205921002155	catalytic site [active]
205921002156	Cna protein B-type domain; Region: Cna_B; pfam05738
205921002157	Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198
205921002158	metal ion-dependent adhesion site (MIDAS); other site
205921002159	Cna protein B-type domain; Region: Cna_B; pfam05738
205921002160	Cna protein B-type domain; Region: Cna_B; pfam05738
205921002161	Beta-lactamase; Region: Beta-lactamase; pfam00144
205921002162	Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680
205921002163	ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: COG4586
205921002164	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
205921002165	Walker A/P-loop; other site
205921002166	ATP binding site [chemical binding]; other site
205921002167	Q-loop/lid; other site
205921002168	ABC transporter signature motif; other site
205921002169	Walker B; other site
205921002170	D-loop; other site
205921002171	H-loop/switch region; other site
205921002172	ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4587
205921002173	ABC-2 family transporter protein; Region: ABC2_membrane_6; cl01496
205921002174	ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG3694
205921002175	Acyl transferase domain; Region: Acyl_transf_1; cl08282
205921002176	3-oxoacyl-(acyl-carrier-protein) reductase; Region: 3oxo_ACP_reduc; TIGR01830
205921002177	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
205921002178	NAD(P) binding site [chemical binding]; other site
205921002179	active site
205921002180	Phosphopantetheine attachment site; Region: PP-binding; cl09936
205921002181	FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288
205921002182	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
205921002183	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
205921002184	Walker A/P-loop; other site
205921002185	ATP binding site [chemical binding]; other site
205921002186	Q-loop/lid; other site
205921002187	ABC transporter signature motif; other site
205921002188	Walker B; other site
205921002189	D-loop; other site
205921002190	H-loop/switch region; other site
205921002191	ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698
205921002192	Aminomethyltransferase folate-binding domain; Region: GCV_T; pfam01571
205921002193	Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834
205921002194	3-oxoacyl-(acyl carrier protein) synthase II; Provisional; Region: PRK14691
205921002195	dimer interface [polypeptide binding]; other site
205921002196	active site
205921002197	Condensing enzymes; Family of enzymes that catalyze a (decarboxylating or non-decarboxylating) Claisen-like condensation reaction. Members are share strong structural similarity, and are involved in the synthesis and degradation of fatty acids, and the...; Region: cond_enzymes; cl09938
205921002198	Glycosyl transferases, related to UDP-glucuronosyltransferase [Carbohydrate transport and metabolism / Signal transduction mechanisms]; Region: COG1819
205921002199	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
205921002200	putative cross-wall-targeting lipoprotein signal; Region: strep_RK_lipo; TIGR03726
205921002201	Peptidase S8 family domain in Streptococcal C5a peptidases; Region: Peptidases_S8_C5a_Peptidase; cd07475
205921002202	putative active site [active]
205921002203	catalytic triad [active]
205921002204	Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459
205921002205	catalytic residues [active]
205921002206	Fn3-like domain (DUF1034); Region: DUF1034; pfam06280
205921002207	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
205921002208	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
205921002209	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
205921002210	ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]; Region: LolE; COG4591
205921002211	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
205921002212	FtsX-like permease family; Region: FtsX; pfam02687
205921002213	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
205921002214	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
205921002215	Walker A/P-loop; other site
205921002216	ATP binding site [chemical binding]; other site
205921002217	Q-loop/lid; other site
205921002218	ABC transporter signature motif; other site
205921002219	Walker B; other site
205921002220	D-loop; other site
205921002221	H-loop/switch region; other site
205921002222	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4529
205921002223	FAD-NAD(P)-binding; Region: NAD_binding_9; pfam13454
205921002224	DNA/RNA non-specific endonuclease; Region: Endonuclea_NS_2; cl17626
205921002225	DNA/RNA non-specific endonuclease; Region: Endonuclease_NS; smart00892
205921002226	SNARE associated Golgi protein; Region: SNARE_assoc; cl00429
205921002227	Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586
205921002228	ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: COG4619
205921002229	First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225
205921002230	Walker A/P-loop; other site
205921002231	ATP binding site [chemical binding]; other site
205921002232	Q-loop/lid; other site
205921002233	ABC transporter signature motif; other site
205921002234	Walker B; other site
205921002235	D-loop; other site
205921002236	H-loop/switch region; other site
205921002237	ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG0390
205921002238	Transcriptional regulator [Transcription]; Region: LysR; COG0583
205921002239	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
205921002240	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
205921002241	dimerization interface [polypeptide binding]; other site
205921002242	Predicted membrane protein, putative toxin regulator [General function prediction only]; Region: PfoR; COG3641
205921002243	Phosphotransferase system, EIIC; Region: PTS_EIIC_2; pfam13303
205921002244	D-Lactate dehydrogenase and D-2-Hydroxyisocaproic acid dehydrogenase (D-HicDH), NAD-binding and catalytic domains; Region: LDH; cd12186
205921002245	D-lactate dehydrogenase; Validated; Region: PRK08605
205921002246	homodimer interface [polypeptide binding]; other site
205921002247	ligand binding site [chemical binding]; other site
205921002248	NAD binding site [chemical binding]; other site
205921002249	catalytic site [active]
205921002250	MFS/sugar transport protein; Region: MFS_2; pfam13347
205921002251	melibiose:sodium symporter; Provisional; Region: PRK10429; cl15392
205921002252	Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524
205921002253	2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166
205921002254	substrate binding site [chemical binding]; other site
205921002255	ATP binding site [chemical binding]; other site
205921002256	beta-D-glucuronidase; Provisional; Region: PRK10150
205921002257	Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837
205921002258	Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703
205921002259	Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836
205921002260	Transcriptional regulators [Transcription]; Region: FadR; COG2186
205921002261	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
205921002262	DNA-binding site [nucleotide binding]; DNA binding site
205921002263	FCD domain; Region: FCD; pfam07729
205921002264	2-keto-3-deoxy-6-phosphogluconate aldolase [Carbohydrate transport and metabolism]; Region: Eda; COG0800
205921002265	KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452
205921002266	active site
205921002267	intersubunit interface [polypeptide binding]; other site
205921002268	catalytic residue [active]
205921002269	Glucuronate isomerase; Region: UxaC; pfam02614
205921002270	Glucuronate isomerase [Carbohydrate transport and metabolism]; Region: UxaC; COG1904
205921002271	mannonate dehydratase; Provisional; Region: PRK03906
205921002272	mannonate dehydratase; Region: uxuA; TIGR00695
205921002273	D-mannonate oxidoreductase; Provisional; Region: PRK08277
205921002274	putative D-mannonate oxidoreductase, classical (c) SDR; Region: mannonate_red_SDR_c; cd08935
205921002275	putative NAD(P) binding site [chemical binding]; other site
205921002276	active site
205921002277	Haloacid dehalogenase-like hydrolase; Region: HAD_2; pfam13419
205921002278	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
205921002279	motif II; other site
205921002280	Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472
205921002281	Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; cl07971
205921002282	Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006
205921002283	Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321
205921002284	Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092
205921002285	active site
205921002286	catabolite control protein A; Region: ccpA; TIGR01481
205921002287	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
205921002288	DNA binding site [nucleotide binding]
205921002289	domain linker motif; other site
205921002290	Ligand-binding domain of the catabolite control protein A (CcpA), which functions as the major transcriptional regulator of carbon catabolite repression/regulation; Region: PBP1_CcpA_like; cd06298
205921002291	dimerization interface [polypeptide binding]; other site
205921002292	effector binding site; other site
205921002293	cytoplasmic alpha-amylase; Reviewed; Region: PRK09441
205921002294	Alpha amylase catalytic domain found in bacterial and fungal Alpha amylases (also called 1,4-alpha-D-glucan-4-glucanohydrolase); Region: AmyAc_bac_fung_AmyA; cd11318
205921002295	active site
205921002296	Na/Ca binding site [ion binding]; other site
205921002297	catalytic site [active]
205921002298	Domain of unknown function (DUF1939); Region: DUF1939; pfam09154
205921002299	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
205921002300	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
205921002301	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
205921002302	This family is most closely related to the GT1 family of glycosyltransferases. UDP-glucose-diacylglycerol glucosyltransferase (UGDG; also known as 1,2-diacylglycerol 3-glucosyltransferase) catalyzes the transfer of glucose from UDP-glucose to 1; Region: GT1_UGDG_like; cd03817
205921002303	putative ADP-binding pocket [chemical binding]; other site
205921002304	threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK00413
205921002305	TGS _ThrRS_N:  ThrRS (threonyl-tRNA Synthetase)  is a class II tRNA synthetase that couples threonine to its cognate tRNA.  In addition to its catalytic and anticodon-binding domains, ThrRS has an N-terminal TGS domain, named after the ThrRS, GTPase, and...; Region: TGS_ThrRS_N; cd01667
205921002306	Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863
205921002307	Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771
205921002308	active site
205921002309	dimer interface [polypeptide binding]; other site
205921002310	motif 1; other site
205921002311	motif 2; other site
205921002312	motif 3; other site
205921002313	ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860
205921002314	anticodon binding site; other site
205921002315	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
205921002316	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
205921002317	active site
205921002318	phosphorylation site [posttranslational modification]
205921002319	intermolecular recognition site; other site
205921002320	dimerization interface [polypeptide binding]; other site
205921002321	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
205921002322	DNA binding site [nucleotide binding]
205921002323	Protein of unknown function (DUF3114); Region: DUF3114; pfam11311
205921002324	Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413
205921002325	ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215
205921002326	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
205921002327	dimer interface [polypeptide binding]; other site
205921002328	conserved gate region; other site
205921002329	putative PBP binding loops; other site
205921002330	ABC-ATPase subunit interface; other site
205921002331	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
205921002332	dimer interface [polypeptide binding]; other site
205921002333	conserved gate region; other site
205921002334	putative PBP binding loops; other site
205921002335	ABC-ATPase subunit interface; other site
205921002336	bifunctional adhesin/ABC transporter aspartate/glutamate-binding protein; Reviewed; Region: PRK11917
205921002337	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
205921002338	substrate binding pocket [chemical binding]; other site
205921002339	membrane-bound complex binding site; other site
205921002340	hinge residues; other site
205921002341	ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126
205921002342	ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262
205921002343	Walker A/P-loop; other site
205921002344	ATP binding site [chemical binding]; other site
205921002345	Q-loop/lid; other site
205921002346	ABC transporter signature motif; other site
205921002347	Walker B; other site
205921002348	D-loop; other site
205921002349	H-loop/switch region; other site
205921002350	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
205921002351	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
205921002352	active site
205921002353	phosphorylation site [posttranslational modification]
205921002354	intermolecular recognition site; other site
205921002355	dimerization interface [polypeptide binding]; other site
205921002356	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
205921002357	DNA binding site [nucleotide binding]
205921002358	phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966
205921002359	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
205921002360	putative active site [active]
205921002361	heme pocket [chemical binding]; other site
205921002362	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
205921002363	dimer interface [polypeptide binding]; other site
205921002364	phosphorylation site [posttranslational modification]
205921002365	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
205921002366	ATP binding site [chemical binding]; other site
205921002367	Mg2+ binding site [ion binding]; other site
205921002368	G-X-G motif; other site
205921002369	Metal-dependent hydrolases of the beta-lactamase superfamily I [General function prediction only]; Region: PhnP; COG1235
205921002370	Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220
205921002371	Protein of unknown function (DUF454); Region: DUF454; cl01063
205921002372	ribonuclease III; Reviewed; Region: rnc; PRK00102
205921002373	RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593
205921002374	dimerization interface [polypeptide binding]; other site
205921002375	active site
205921002376	metal binding site [ion binding]; metal-binding site
205921002377	Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048
205921002378	dsRNA binding site [nucleotide binding]; other site
205921002379	chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168
205921002380	ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278
205921002381	Walker A/P-loop; other site
205921002382	ATP binding site [chemical binding]; other site
205921002383	Q-loop/lid; other site
205921002384	SMC proteins Flexible Hinge Domain; Region: SMC_hinge; smart00968
205921002385	ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278
205921002386	ABC transporter signature motif; other site
205921002387	Walker B; other site
205921002388	D-loop; other site
205921002389	H-loop/switch region; other site
205921002390	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
205921002391	haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282
205921002392	active site
205921002393	motif I; other site
205921002394	motif II; other site
205921002395	haloacid dehalogenase-like hydrolase; Region: HAD; cl17202
205921002396	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
205921002397	haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282
205921002398	active site
205921002399	motif I; other site
205921002400	motif II; other site
205921002401	haloacid dehalogenase-like hydrolase; Region: HAD; cl17202
205921002402	signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416
205921002403	SRP54-type protein, helical bundle domain; Region: SRP54_N; pfam02881
205921002404	The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115
205921002405	P loop; other site
205921002406	GTP binding site [chemical binding]; other site
205921002407	Predicted membrane protein [Function unknown]; Region: COG3689
205921002408	Predicted permeases [General function prediction only]; Region: COG0701
205921002409	probable oxidoreductase, LLM family; Region: LLM_2I7G; TIGR03858
205921002410	Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases [Energy production and conversion]; Region: COG2141
205921002411	Transcriptional accessory protein [Transcription]; Region: Tex; COG2183
205921002412	Tex-like protein N-terminal domain; Region: Tex_N; pfam09371
205921002413	Likely ribonuclease with RNase H fold; Region: YqgFc; smart00732
205921002414	S1_Tex: The C-terminal S1 domain of a transcription accessory factor called Tex, which has been characterized in Bordetella pertussis and Pseudomonas aeruginosa. The tex gene is essential in Bortella pertusis and is named for its role in toxin expression; Region: S1_Tex; cd05685
205921002415	RNA binding site [nucleotide binding]; other site
205921002416	hypothetical protein; Provisional; Region: PRK04351
205921002417	SprT homologues; Region: SprT; cl01182
205921002418	Putative stress-responsive transcriptional regulator [Transcription / Signal transduction mechanisms]; Region: PspC; COG1983
205921002419	HPr kinase/phosphorylase; Provisional; Region: PRK05428
205921002420	HPr Serine kinase N terminus; Region: Hpr_kinase_N; pfam02603
205921002421	HprK/P, the bifunctional histidine-containing protein kinase/phosphatase, controls the phosphorylation state of the phosphocarrier protein HPr and regulates the utilization of carbon sources by gram-positive bacteria. It catalyzes both the ATP-dependent...; Region: HprK_C; cd01918
205921002422	Hpr binding site; other site
205921002423	active site
205921002424	homohexamer subunit interaction site [polypeptide binding]; other site
205921002425	Prolipoprotein diacylglyceryl transferase; Region: LGT; pfam01790
205921002426	Uncharacterized protein containing a divergent version of the methyl-accepting chemotaxis-like domain [General function prediction only]; Region: COG4768
205921002427	YtxH-like protein; Region: YtxH; pfam12732
205921002428	Protein of unknown function (DUF3270); Region: DUF3270; pfam11674
205921002429	Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826
205921002430	Peptidase family U32; Region: Peptidase_U32; pfam01136
205921002431	Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826
205921002432	Members of the ICL/PEPM_KPHMT enzyme superfamily catalyze the formation and cleavage of either P-C or C-C bonds. Typical members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate...; Region: ICL_KPHMT; cl00435
205921002433	Peptidase family U32; Region: Peptidase_U32; pfam01136
205921002434	Uncharacterized protein conserved in bacteria (DUF2128); Region: DUF2128; pfam09901
205921002435	manganese transport protein MntH; Reviewed; Region: PRK00701
205921002436	Natural resistance-associated macrophage protein; Region: Nramp; pfam01566
205921002437	riboflavin biosynthesis protein RibD; Region: eubact_ribD; TIGR00326
205921002438	Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284
205921002439	catalytic motif [active]
205921002440	Zn binding site [ion binding]; other site
205921002441	RibD C-terminal domain; Region: RibD_C; cl17279
205921002442	riboflavin synthase subunit alpha; Provisional; Region: PRK09289
205921002443	Lumazine binding domain; Region: Lum_binding; pfam00677
205921002444	Lumazine binding domain; Region: Lum_binding; pfam00677
205921002445	bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II protein; Provisional; Region: PRK09311
205921002446	3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; pfam00926
205921002447	GTP cyclohydrolase II (RibA).  GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641
205921002448	dimerization interface [polypeptide binding]; other site
205921002449	active site
205921002450	lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209
205921002451	homopentamer interface [polypeptide binding]; other site
205921002452	active site
205921002453	lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484
205921002454	LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322
205921002455	dimer interface [polypeptide binding]; other site
205921002456	putative anticodon binding site; other site
205921002457	Lys_tRNA synthetase (LysRS) class II core domain. Class II LysRS is a dimer which attaches a lysine to the 3' OH group of ribose of the appropriate tRNA. Its assignment to class II aaRS is based upon its structure and the presence of three...; Region: LysRS_core; cd00775
205921002458	motif 1; other site
205921002459	active site
205921002460	motif 2; other site
205921002461	motif 3; other site
205921002462	Predicted hydrolase (HAD superfamily) [General function prediction only]; Region: COG1011
205921002463	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
205921002464	motif II; other site
205921002465	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
205921002466	catalytic core [active]
205921002467	This CD includes cysteinyl-tRNA(Pro) deacylases from Haemophilus influenzae and Escherichia coli and other related bacterial proteins. These trans-acting, single-domain proteins are homologs of ProX and also the cis-acting prolyl-tRNA synthetase (ProRS)...; Region: YbaK_deacylase; cd00002
205921002468	putative deacylase active site [active]
205921002469	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
205921002470	NADH(P)-binding; Region: NAD_binding_10; pfam13460
205921002471	NAD(P) binding site [chemical binding]; other site
205921002472	active site
205921002473	Lyzozyme M1 (1,4-beta-N-acetylmuramidase) [Cell envelope biogenesis, outer membrane]; Region: Acm; COG3757
205921002474	PlyB is a bacteriophage endolysin that displays potent lytic activity toward Bacillus anthracis.  PlyB has an N-terminal glycosyl hydrolase family 25 (GH25) catalytic domain and a C-terminal bacterial SH3-like domain, SH3b.  Both domains are required for...; Region: GH25_PlyB-like; cd06523
205921002475	active site
205921002476	ECF-type riboflavin transporter, S component; Region: ECF-ribofla_trS; cl17272
205921002477	Protein of unknown function (DUF3816); Region: DUF3816; pfam12822
205921002478	oligoendopeptidase F; Region: pepF; TIGR00181
205921002479	Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins); Region: GluZincin; cl14813
205921002480	Zn binding site [ion binding]; other site
205921002481	phosphoenolpyruvate carboxylase; Reviewed; Region: PRK00009
205921002482	Phosphoenolpyruvate carboxylase [Energy production and conversion]; Region: Ppc; COG2352
205921002483	Bacterial cell division membrane protein [Cell division and chromosome partitioning]; Region: FtsW; COG0772
205921002484	elongation factor Tu; Reviewed; Region: PRK00049
205921002485	Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884
205921002486	G1 box; other site
205921002487	GEF interaction site [polypeptide binding]; other site
205921002488	GTP/Mg2+ binding site [chemical binding]; other site
205921002489	Switch I region; other site
205921002490	G2 box; other site
205921002491	G3 box; other site
205921002492	Switch II region; other site
205921002493	G4 box; other site
205921002494	G5 box; other site
205921002495	EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697
205921002496	Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707
205921002497	Antibiotic Binding Site [chemical binding]; other site
205921002498	triosephosphate isomerase; Provisional; Region: PRK14567
205921002499	Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311
205921002500	substrate binding site [chemical binding]; other site
205921002501	dimer interface [polypeptide binding]; other site
205921002502	catalytic triad [active]
205921002503	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
205921002504	catalytic core [active]
205921002505	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
205921002506	Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768
205921002507	Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717
205921002508	Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717
205921002509	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905
205921002510	recombination protein RecR; Reviewed; Region: recR; PRK00076
205921002511	RecR protein; Region: RecR; pfam02132
205921002512	TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR.  RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025
205921002513	putative active site [active]
205921002514	putative metal-binding site [ion binding]; other site
205921002515	tetramer interface [polypeptide binding]; other site
205921002516	D-alanyl-alanine synthetase A; Reviewed; Region: ddl; PRK01966
205921002517	D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820
205921002518	D-ala D-ala ligase C-terminus; Region: Dala_Dala_lig_C; pfam07478
205921002519	UDP-N-acetylmuramyl pentapeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurF; COG0770
205921002520	Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225
205921002521	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
205921002522	oxalate/formate antiporter family transporter; Region: 2A0111; TIGR00890
205921002523	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
205921002524	putative substrate translocation pore; other site
205921002525	Integral membrane protein (intg_mem_TP0381); Region: Intg_mem_TP0381; pfam09529
205921002526	Gram positive anchor; Region: Gram_pos_anchor; pfam00746
205921002527	peptide chain release factor 3; Provisional; Region: prfC; PRK00741
205921002528	Release Factor 3 (RF3) protein involved in the terminal step of translocation in bacteria; Region: RF3; cd04169
205921002529	G1 box; other site
205921002530	putative GEF interaction site [polypeptide binding]; other site
205921002531	GTP/Mg2+ binding site [chemical binding]; other site
205921002532	Switch I region; other site
205921002533	G2 box; other site
205921002534	G3 box; other site
205921002535	Switch II region; other site
205921002536	G4 box; other site
205921002537	G5 box; other site
205921002538	RF3_II: this subfamily represents the domain II of bacterial Release Factor 3 (RF3). Termination of protein synthesis by the ribosome requires two release factor (RF) classes. The class II RF3 is a GTPase that removes class I RFs (RF1 or RF2) from the...; Region: RF3_II; cd03689
205921002539	Pleckstrin homology (PH)-like domains in bacteria (PHb); Region: PH-like_bacteria; cd13225
205921002540	pentamer interface [polypeptide binding]; other site
205921002541	dodecaamer interface [polypeptide binding]; other site
205921002542	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
205921002543	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
205921002544	Walker A/P-loop; other site
205921002545	ATP binding site [chemical binding]; other site
205921002546	Q-loop/lid; other site
205921002547	ABC transporter signature motif; other site
205921002548	Walker B; other site
205921002549	D-loop; other site
205921002550	H-loop/switch region; other site
205921002551	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
205921002552	dimer interface [polypeptide binding]; other site
205921002553	conserved gate region; other site
205921002554	putative PBP binding loops; other site
205921002555	ABC-ATPase subunit interface; other site
205921002556	ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464
205921002557	NLPA lipoprotein; Region: Lipoprotein_9; cl17547
205921002558	ATP-dependent RNA helicase SrmB; Provisional; Region: PRK11192
205921002559	DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker  B motif; Region: DEADc; cd00268
205921002560	ATP binding site [chemical binding]; other site
205921002561	Mg++ binding site [ion binding]; other site
205921002562	motif III; other site
205921002563	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
205921002564	nucleotide binding region [chemical binding]; other site
205921002565	ATP-binding site [chemical binding]; other site
205921002566	The GIY-YIG domain of uncharacterized protein family UPF0213 related to structure-specific endonuclease SLX1; Region: GIY-YIG_UPF0213; cd10456
205921002567	GIY-YIG motif/motif A; other site
205921002568	putative active site [active]
205921002569	putative metal binding site [ion binding]; other site
205921002570	Predicted O-methyltransferase [General function prediction only]; Region: COG4123
205921002571	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
205921002572	S-adenosylmethionine binding site [chemical binding]; other site
205921002573	1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204
205921002574	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989
205921002575	putative acyl-acceptor binding pocket; other site
205921002576	SLBB domain; Region: SLBB; pfam10531
205921002577	comEA protein; Region: comE; TIGR01259
205921002578	Predicted membrane metal-binding protein [General function prediction only]; Region: ComEC; COG0658
205921002579	Domain of unknown function (DUF4131); Region: DUF4131; pfam13567
205921002580	Competence protein; Region: Competence; pfam03772
205921002581	Predicted hydrolase (metallo-beta-lactamase superfamily) [General function prediction only]; Region: ComEC; COG2333
205921002582	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
205921002583	haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282
205921002584	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
205921002585	active site
205921002586	motif I; other site
205921002587	motif II; other site
205921002588	haloacid dehalogenase-like hydrolase; Region: HAD; cl17202
205921002589	Transcriptional regulators [Transcription]; Region: PurR; COG1609
205921002590	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
205921002591	DNA binding site [nucleotide binding]
205921002592	domain linker motif; other site
205921002593	Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011
205921002594	Protein of unknown function (DUF2424); Region: DUF2424; pfam10340
205921002595	alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859
205921002596	Methyltransferase domain; Region: Methyltransf_23; pfam13489
205921002597	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
205921002598	S-adenosylmethionine binding site [chemical binding]; other site
205921002599	DNA polymerase III subunit delta; Reviewed; Region: holA; PRK05574
205921002600	DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144
205921002601	Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605
205921002602	Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081
205921002603	Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777
205921002604	transcriptional antiterminator BglG; Provisional; Region: PRK09772
205921002605	CAT RNA binding domain; Region: CAT_RBD; pfam03123
205921002606	PRD domain; Region: PRD; pfam00874
205921002607	PRD domain; Region: PRD; pfam00874
205921002608	PTS system, beta-glucoside-specific IIABC component; Region: PTS-II-ABC-beta; TIGR01995
205921002609	PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212
205921002610	active site turn [active]
205921002611	phosphorylation site [posttranslational modification]
205921002612	Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263
205921002613	PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_glc; cd00210
205921002614	HPr interaction site; other site
205921002615	glycerol kinase (GK) interaction site [polypeptide binding]; other site
205921002616	active site
205921002617	phosphorylation site [posttranslational modification]
205921002618	Beta-glucosidase/6-phospho-beta-glucosidase/beta- galactosidase [Carbohydrate transport and metabolism]; Region: BglB; COG2723
205921002619	beta-galactosidase; Region: BGL; TIGR03356
205921002620	Sugar diacid utilization regulator [Transcription / Signal transduction mechanisms]; Region: CdaR; COG3835
205921002621	Putative sugar diacid recognition; Region: Diacid_rec; pfam05651
205921002622	PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556
205921002623	glycerate kinase; Region: TIGR00045
205921002624	H+/gluconate symporter and related permeases [Carbohydrate transport and metabolism / Amino acid transport and metabolism]; Region: GntT; COG2610
205921002625	Beta-lactamase enzyme family; Region: Beta-lactamase2; pfam13354
205921002626	Transcriptional regulators [Transcription]; Region: MarR; COG1846
205921002627	MarR family; Region: MarR; pfam01047
205921002628	S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Provisional; Region: queA; PRK00147
205921002629	S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Region: queA; TIGR00113
205921002630	Nodulin-21 and CCC1-related protein family; Region: Nodulin-21_like_1; cd02432
205921002631	6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363
205921002632	GlcN6P_deaminase: Glucosamine-6-phosphate (GlcN6P) deaminase subfamily; GlcN6P deaminase catalyzes the reversible conversion of GlcN6P to D-fructose-6-phosphate (Fru6P) and ammonium. The reaction is an aldo-keto isomerization coupled with an amination or...; Region: GlcN6P_deaminase; cd01399
205921002633	active site
205921002634	trimer interface [polypeptide binding]; other site
205921002635	allosteric site; other site
205921002636	active site lid [active]
205921002637	hexamer (dimer of trimers) interface [polypeptide binding]; other site
205921002638	Predicted glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: ECM4; COG0435
205921002639	Glutathione S-transferase, N-terminal domain; Region: GST_N_2; pfam13409
205921002640	C-terminal, alpha helical domain of Class Omega-like Glutathione S-transferases; Region: GST_C_Omega_like; cd03190
205921002641	putative dimer interface [polypeptide binding]; other site
205921002642	N-terminal domain interface [polypeptide binding]; other site
205921002643	putative substrate binding pocket (H-site) [chemical binding]; other site
205921002644	16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187
205921002645	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
205921002646	RNA binding surface [nucleotide binding]; other site
205921002647	Pseudouridine synthase, Escherichia coli RsuA like; Region: PseudoU_synth_RsuA; cd02553
205921002648	active site
205921002649	uracil binding [chemical binding]; other site
205921002650	Major Facilitator Superfamily; Region: MFS_1; pfam07690
205921002651	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
205921002652	putative substrate translocation pore; other site
205921002653	Competence protein CoiA-like family; Region: CoiA; pfam06054
205921002654	Oligoendopeptidase F [Amino acid transport and metabolism]; Region: COG1164
205921002655	Peptidase family M3B Oligopeptidase F (PepF); Region: M3B_PepF_3; cd09608
205921002656	active site
205921002657	Zn binding site [ion binding]; other site
205921002658	Predicted phosphatases [General function prediction only]; Region: Gph; COG0546
205921002659	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
205921002660	motif II; other site
205921002661	Predicted O-methyltransferase [General function prediction only]; Region: COG4122
205921002662	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
205921002663	S-adenosylmethionine binding site [chemical binding]; other site
205921002664	foldase protein PrsA; Reviewed; Region: prsA; PRK01326
205921002665	Tubby C 2; Region: Tub_2; cl02043
205921002666	alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252
205921002667	Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673
205921002668	motif 1; other site
205921002669	active site
205921002670	motif 2; other site
205921002671	motif 3; other site
205921002672	Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863
205921002673	DHHA1 domain; Region: DHHA1; pfam02272
205921002674	Protein of unknown function (DUF554); Region: DUF554; pfam04474
205921002675	A4GalT_like proteins catalyze the addition of galactose or glucose residues to the lipooligosaccharide (LOS) or lipopolysaccharide (LPS) of the bacterial cell surface; Region: GT8_A4GalT_like; cd04194
205921002676	Glycosyl transferase family 8; Region: Glyco_transf_8; pfam01501
205921002677	Ligand binding site; other site
205921002678	metal-binding site
205921002679	Pleckstrin homology-like domain; Region: PH-like; cl17171
205921002680	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
205921002681	non-specific DNA binding site [nucleotide binding]; other site
205921002682	salt bridge; other site
205921002683	sequence-specific DNA binding site [nucleotide binding]; other site
205921002684	Protein of unknown function (DUF3169); Region: DUF3169; pfam11368
205921002685	putative proton-coupled thiamine transporter YuaJ; Region: thia_yuaJ; TIGR02357
205921002686	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3666
205921002687	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
205921002688	Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751
205921002689	ribonucleotide-diphosphate reductase subunit beta; Provisional; Region: nrdF2; PRK13966
205921002690	Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049
205921002691	dimer interface [polypeptide binding]; other site
205921002692	putative radical transfer pathway; other site
205921002693	diiron center [ion binding]; other site
205921002694	tyrosyl radical; other site
205921002695	ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK07306
205921002696	Ribonucleotide reductase N-terminal; Region: RNR_N; pfam08343
205921002697	Class I ribonucleotide reductase; Region: RNR_I; cd01679
205921002698	active site
205921002699	dimer interface [polypeptide binding]; other site
205921002700	catalytic residues [active]
205921002701	effector binding site; other site
205921002702	Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939
205921002703	NrdH-redoxin (NrdH) family; NrdH is a small monomeric protein with a conserved redox active CXXC motif within a TRX fold, characterized by a glutaredoxin (GRX)-like sequence and TRX-like activity profile. In vitro, it displays protein disulfide reductase...; Region: NrdH; cd02976
205921002704	catalytic residues [active]
205921002705	Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367
205921002706	dimerization domain swap beta strand [polypeptide binding]; other site
205921002707	regulatory protein interface [polypeptide binding]; other site
205921002708	active site
205921002709	regulatory phosphorylation site [posttranslational modification]; other site
205921002710	Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism]; Region: PtsA; COG1080
205921002711	PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524
205921002712	PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391
205921002713	PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896
205921002714	NADP+-dependent non-phosphorylating glyceraldehyde 3-phosphate dehydrogenase and ALDH family 11; Region: ALDH_F11_NP-GAPDH; cd07082
205921002715	NADP-dependent glyceraldehyde-3-phosphate dehydrogenase; Provisional; Region: PLN00412
205921002716	tetrameric interface [polypeptide binding]; other site
205921002717	activator binding site; other site
205921002718	NADP binding site [chemical binding]; other site
205921002719	substrate binding site [chemical binding]; other site
205921002720	catalytic residues [active]
205921002721	Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726
205921002722	Catalytic NodB homology domain of the carbohydrate esterase 4 superfamily; Region: CE4_SF; cl15692
205921002723	DEAD-like helicases superfamily; Region: DEXDc; smart00487
205921002724	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251
205921002725	ATP binding site [chemical binding]; other site
205921002726	putative Mg++ binding site [ion binding]; other site
205921002727	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
205921002728	nucleotide binding region [chemical binding]; other site
205921002729	ATP-binding site [chemical binding]; other site
205921002730	Uridine kinase [Nucleotide transport and metabolism]; Region: Udk; COG0572
205921002731	Uridine monophosphate kinase (UMPK, EC 2.7.1.48), also known as uridine kinase or uridine-cytidine kinase (UCK), catalyzes the reversible phosphoryl transfer from ATP to uridine or cytidine to yield UMP or CMP. In the primidine nucleotide-salvage pathway; Region: UMPK; cd02023
205921002732	Sugar specificity; other site
205921002733	Pyrimidine base specificity; other site
205921002734	ATP-binding site [chemical binding]; other site
205921002735	GAF domain-containing protein [Signal transduction mechanisms]; Region: COG1956
205921002736	DNA polymerase III subunits gamma and tau; Validated; Region: PRK05563
205921002737	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
205921002738	Walker A motif; other site
205921002739	ATP binding site [chemical binding]; other site
205921002740	DNA polymerase III subunit delta'; Validated; Region: PRK08485
205921002741	Walker B motif; other site
205921002742	arginine finger; other site
205921002743	Biotin operon repressor [Transcription]; Region: BirA; COG1654
205921002744	bifunctional biotin--[acetyl-CoA-carboxylase] synthetase/biotin operon repressor; Provisional; Region: PRK11886
205921002745	Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; pfam03099
205921002746	Biotin protein ligase C terminal domain; Region: BPL_C; pfam02237
205921002747	S-adenosylmethionine synthetase; Validated; Region: PRK05250
205921002748	S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438
205921002749	S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772
205921002750	S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773
205921002751	Staphylococcus aureus coagulase; Region: Coagulase; pfam08764
205921002752	Thiamine-precursor transporter protein (ThiW); Region: ThiW; pfam09512
205921002753	ABC-type cobalt transport system, permease component; Region: ABC_cobalt; pfam09819
205921002754	First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225
205921002755	cobalt transport protein ATP-binding subunit; Region: cbiO; TIGR01166
205921002756	Walker A/P-loop; other site
205921002757	ATP binding site [chemical binding]; other site
205921002758	Q-loop/lid; other site
205921002759	ABC transporter signature motif; other site
205921002760	Walker B; other site
205921002761	D-loop; other site
205921002762	H-loop/switch region; other site
205921002763	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
205921002764	cobalt transport protein ATP-binding subunit; Region: cbiO; TIGR01166
205921002765	Walker A/P-loop; other site
205921002766	ATP binding site [chemical binding]; other site
205921002767	Q-loop/lid; other site
205921002768	ABC transporter signature motif; other site
205921002769	Walker B; other site
205921002770	D-loop; other site
205921002771	H-loop/switch region; other site
205921002772	TENA/THI-4/PQQC family; Region: TENA_THI-4; cl15243
205921002773	4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169
205921002774	substrate binding site [chemical binding]; other site
205921002775	dimer interface [polypeptide binding]; other site
205921002776	ATP binding site [chemical binding]; other site
205921002777	4-methyl-5-beta-hydroxyethylthiazole (Thz) kinase catalyzes the phosphorylation of the hydroxylgroup of Thz. A reaction that allows cells to recycle Thz into the thiamine biosynthesis pathway, as an alternative to its synthesis from cysteine, tyrosine...; Region: THZ_kinase; cd01170
205921002778	substrate binding site [chemical binding]; other site
205921002779	multimerization interface [polypeptide binding]; other site
205921002780	ATP binding site [chemical binding]; other site
205921002781	Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564
205921002782	thiamine phosphate binding site [chemical binding]; other site
205921002783	active site
205921002784	pyrophosphate binding site [ion binding]; other site
205921002785	UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072
205921002786	UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555
205921002787	hinge; other site
205921002788	active site
205921002789	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
205921002790	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
205921002791	Predicted transcriptional regulator containing CBS domains [Transcription]; Region: COG4109
205921002792	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
205921002793	DNA-binding site [nucleotide binding]; DNA binding site
205921002794	DRTGG domain; Region: DRTGG; pfam07085
205921002795	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with a DRTGG domain upstream. The function of the DRTGG domain, named after its conserved residues, is unknown. CBS is a small domain originally...; Region: CBS_pair_DRTGG_assoc; cd04596
205921002796	The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cd03440
205921002797	active site 2 [active]
205921002798	active site 1 [active]
205921002799	Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086
205921002800	active site
205921002801	Ribonuclease BN family enzyme [Replication, recombination, and repair]; Region: Rbn; COG1295
205921002802	GtrA-like protein; Region: GtrA; pfam04138
205921002803	Predicted membrane protein [Function unknown]; Region: COG2246
205921002804	Predicted membrane protein [Function unknown]; Region: COG4708
205921002805	NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956
205921002806	NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114
205921002807	nucleotide binding pocket [chemical binding]; other site
205921002808	K-X-D-G motif; other site
205921002809	catalytic site [active]
205921002810	NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120
205921002811	NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119
205921002812	Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027
205921002813	Dimer interface [polypeptide binding]; other site
205921002814	BRCT sequence motif; other site
205921002815	putative lipid kinase; Reviewed; Region: PRK13055
205921002816	Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781
205921002817	Diacylglycerol kinase catalytic domain; Region: DAGK_cat; cl17465
205921002818	Family 41 Carbohydrate-Binding Module from pullulanase-like enzymes; Region: CBM41_pullulanase; cd10315
205921002819	carbohydrate binding site [chemical binding]; other site
205921002820	pullulanase, type I; Region: pulA_typeI; TIGR02104
205921002821	Early set domain associated with the catalytic domain of pullulanase (also called dextrinase and alpha-dextrin endo-1,6-alpha glucosidase); Region: E_set_Pullulanase; cd02860
205921002822	Alpha amylase catalytic domain found in Pullulanase (also called dextrinase; alpha-dextrin endo-1,6-alpha glucosidase), limit dextrinase, and related proteins; Region: AmyAc_Pullulanase_LD-like; cd11341
205921002823	Ca binding site [ion binding]; other site
205921002824	active site
205921002825	catalytic site [active]
205921002826	glycogen branching enzyme; Provisional; Region: PRK12313
205921002827	N-terminal Early set domain associated with the catalytic domain of prokaryotic glycogen branching enzyme; Region: E_set_GBE_prok_N; cd02855
205921002828	Alpha amylase catalytic domain found in the Glycogen branching enzyme (also called 1,4-alpha-glucan branching enzyme); Region: AmyAc_Glg_BE; cd11322
205921002829	active site
205921002830	catalytic site [active]
205921002831	Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; pfam02806
205921002832	glucose-1-phosphate adenylyltransferase; Provisional; Region: glgC; PRK05293
205921002833	ADP-glucose pyrophosphorylase is involved in the biosynthesis of glycogen or starch; Region: ADP_Glucose_PP; cd02508
205921002834	ligand binding site; other site
205921002835	oligomer interface; other site
205921002836	Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651
205921002837	dimer interface [polypeptide binding]; other site
205921002838	N-terminal domain interface [polypeptide binding]; other site
205921002839	sulfate 1 binding site; other site
205921002840	glucose-1-phosphate adenylyltransferase, GlgD subunit; Region: glgD; TIGR02092
205921002841	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
205921002842	active site
205921002843	Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651
205921002844	dimer interface [polypeptide binding]; other site
205921002845	N-terminal domain interface [polypeptide binding]; other site
205921002846	sulfate 1 binding site; other site
205921002847	glycogen synthase; Provisional; Region: glgA; PRK00654
205921002848	This family is most closely related to the GT1 family of glycosyltransferases. Glycogen synthase catalyzes the formation and elongation of the alpha-1,4-glucose backbone using ADP-glucose, the second and key step of glycogen biosynthesis. This family...; Region: GT1_Glycogen_synthase_DULL1_like; cd03791
205921002849	ADP-binding pocket [chemical binding]; other site
205921002850	homodimer interface [polypeptide binding]; other site
205921002851	F0F1 ATP synthase subunit C; Provisional; Region: PRK13467
205921002852	F0F1 ATP synthase subunit A; Validated; Region: PRK05815
205921002853	F0F1-type ATP synthase, subunit a [Energy production and conversion]; Region: AtpB; COG0356
205921002854	F0F1 ATP synthase subunit B; Validated; Region: PRK05759
205921002855	F0F1-type ATP synthase, subunit b [Energy production and conversion]; Region: AtpF; COG0711
205921002856	F0F1 ATP synthase subunit delta; Validated; Region: PRK05758
205921002857	ATP synthase delta (OSCP) subunit; Region: OSCP; pfam00213
205921002858	F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281
205921002859	ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874
205921002860	F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132
205921002861	beta subunit interaction interface [polypeptide binding]; other site
205921002862	Walker A motif; other site
205921002863	ATP binding site [chemical binding]; other site
205921002864	Walker B motif; other site
205921002865	ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306
205921002866	mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151
205921002867	core domain interface [polypeptide binding]; other site
205921002868	delta subunit interface [polypeptide binding]; other site
205921002869	epsilon subunit interface [polypeptide binding]; other site
205921002870	F0F1 ATP synthase subunit beta; Validated; Region: PRK09280
205921002871	ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874
205921002872	F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133
205921002873	alpha subunit interaction interface [polypeptide binding]; other site
205921002874	Walker A motif; other site
205921002875	ATP binding site [chemical binding]; other site
205921002876	Walker B motif; other site
205921002877	inhibitor binding site; inhibition site
205921002878	ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306
205921002879	F0F1 ATP synthase subunit epsilon; Validated; Region: atpC; PRK00571
205921002880	mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152
205921002881	gamma subunit interface [polypeptide binding]; other site
205921002882	epsilon subunit interface [polypeptide binding]; other site
205921002883	LBP interface [polypeptide binding]; other site
205921002884	conserved hypothetical integral membrane protein; Region: int_mem_ywzB; TIGR02327
205921002885	UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072
205921002886	UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555
205921002887	hinge; other site
205921002888	active site
205921002889	DNA-directed RNA polymerase subunit beta; Region: EpuA; pfam11772
205921002890	DNA/RNA non-specific endonuclease; Region: Endonuclease_NS; pfam01223
205921002891	DNA/RNA non-specific endonuclease; Region: Endonuclease_NS; smart00892
205921002892	phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488
205921002893	Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912
205921002894	Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496
205921002895	dimer interface [polypeptide binding]; other site
205921002896	motif 1; other site
205921002897	active site
205921002898	motif 2; other site
205921002899	motif 3; other site
205921002900	Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673
205921002901	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
205921002902	Coenzyme A binding pocket [chemical binding]; other site
205921002903	phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629
205921002904	tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain.  PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796
205921002905	putative tRNA-binding site [nucleotide binding]; other site
205921002906	B3/4 domain; Region: B3_4; pfam03483
205921002907	tRNA synthetase B5 domain; Region: B5; smart00874
205921002908	Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA,  PheRS is an...; Region: PheRS_beta_core; cd00769
205921002909	dimer interface [polypeptide binding]; other site
205921002910	motif 1; other site
205921002911	motif 3; other site
205921002912	motif 2; other site
205921002913	Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; pfam03147
205921002914	Predicted metalloprotease [General function prediction only]; Region: COG2321
205921002915	Putative neutral zinc metallopeptidase; Region: Zn_peptidase; pfam04228
205921002916	ATP-dependent nuclease subunit B; Region: rexB_recomb; TIGR02774
205921002917	PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705
205921002918	helicase-exonuclease AddAB, AddA subunit, Firmicutes type; Region: addA_Gpos; TIGR02785
205921002919	Part of AAA domain; Region: AAA_19; pfam13245
205921002920	Family description; Region: UvrD_C_2; pfam13538
205921002921	PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705
205921002922	CorA-like Mg2+ transporter protein; Region: CorA; pfam01544
205921002923	uncharacterized bacterial subfamily of the Escherichia coli CorA-Salmonella typhimurium ZntB family; Region: EcCorA_ZntB-like_u2; cd12827
205921002924	Cl binding site [ion binding]; other site
205921002925	oligomer interface [polypeptide binding]; other site
205921002926	tRNA modification GTPase TrmE; Reviewed; Region: trmE; PRK05291
205921002927	GTP-binding protein TrmE N-terminus; Region: TrmE_N; pfam10396
205921002928	trmE is a tRNA modification GTPase; Region: trmE; cd04164
205921002929	G1 box; other site
205921002930	GTP/Mg2+ binding site [chemical binding]; other site
205921002931	Switch I region; other site
205921002932	G2 box; other site
205921002933	Switch II region; other site
205921002934	G3 box; other site
205921002935	G4 box; other site
205921002936	G5 box; other site
205921002937	Catalytic cysteine-containing C-terminus of GTPase, MnmE; Region: GTPase_Cys_C; pfam12631
205921002938	ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488
205921002939	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
205921002940	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
205921002941	ABC transporter; Region: ABC_tran_2; pfam12848
205921002942	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
205921002943	Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, alpha subunit [Energy production and conversion]; Region: AcoA; COG1071
205921002944	Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000
205921002945	tetramer interface [polypeptide binding]; other site
205921002946	TPP-binding site [chemical binding]; other site
205921002947	heterodimer interface [polypeptide binding]; other site
205921002948	phosphorylation loop region [posttranslational modification]
205921002949	Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022
205921002950	Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036
205921002951	alpha subunit interface [polypeptide binding]; other site
205921002952	TPP binding site [chemical binding]; other site
205921002953	heterodimer interface [polypeptide binding]; other site
205921002954	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
205921002955	branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856
205921002956	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
205921002957	E3 interaction surface; other site
205921002958	lipoyl attachment site [posttranslational modification]; other site
205921002959	e3 binding domain; Region: E3_binding; pfam02817
205921002960	e3 binding domain; Region: E3_binding; pfam02817
205921002961	2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198
205921002962	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
205921002963	E3 interaction surface; other site
205921002964	lipoyl attachment site [posttranslational modification]; other site
205921002965	dihydrolipoamide dehydrogenase; Region: lipoamide_DH; TIGR01350
205921002966	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
205921002967	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
205921002968	Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095
205921002969	lipoyltransferase and lipoate-protein ligase; Region: lipoyltrans; TIGR00545
205921002970	Bacterial lipoate protein ligase C-terminus; Region: Lip_prot_lig_C; pfam10437
205921002971	Type 1 glutamine amidotransferase (GATase1) domain found in Cobyric Acid Synthase (CobQ); Region: GATase1_CobQ; cd01750
205921002972	catalytic triad [active]
205921002973	UDP-N-acetylmuramyl tripeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurE; COG0769
205921002974	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
205921002975	Domain of unknown function (DUF1727); Region: DUF1727; pfam08353
205921002976	Uncharacterized conserved protein [Function unknown]; Region: COG1624
205921002977	DisA bacterial checkpoint controller nucleotide-binding; Region: DisA_N; pfam02457
205921002978	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4856
205921002979	YbbR-like protein; Region: YbbR; pfam07949
205921002980	phosphoglucosamine mutase; Provisional; Region: glmM; PRK14316
205921002981	GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802
205921002982	active site
205921002983	substrate binding site [chemical binding]; other site
205921002984	metal binding site [ion binding]; metal-binding site
205921002985	Protein of unknown function (DUF1722); Region: DUF1722; cl01284
205921002986	conserved hypothetical protein; Region: TIGR02328
205921002987	Pyrimidine dimer DNA glycosylase; Region: Pyr_excise; pfam03013
205921002988	coproporphyrinogen III oxidase; Provisional; Region: PRK08599
205921002989	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
205921002990	FeS/SAM binding site; other site
205921002991	HemN C-terminal domain; Region: HemN_C; pfam06969
205921002992	Acyl-ACP thioesterase; Region: Acyl-ACP_TE; pfam01643
205921002993	4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586
205921002994	active site
205921002995	The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509
205921002996	active site 2 [active]
205921002997	active site 1 [active]
205921002998	HAD-superfamily subfamily IIA hydrolase, TIGR01457; Region: HAD-SF-IIA-hyp2
205921002999	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
205921003000	active site
205921003001	motif I; other site
205921003002	motif II; other site
205921003003	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
205921003004	Protein of unknown function (DUF1461); Region: DUF1461; pfam07314
205921003005	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cl00083
205921003006	CRISPR/Cas system-associated protein Cas9; Region: Csn1; cd09643
205921003007	CRISPR-associated protein Cas9/Csn1, subtype II/NMEMI; Region: cas_Csn1; TIGR01865
205921003008	CRISPR/Cas system-associated protein Cas1; Region: Cas1_II; cd09720
205921003009	CRISPR/Cas system-associated protein Cas2; Region: Cas2_I_II_III; cd09638
205921003010	CRISPR/Cas system-associated protein Csn2; Region: Csn2; cd09758
205921003011	CRISPR type II-A/NMEMI-associated protein Csn2; Region: cas_Csn2; TIGR01866
205921003012	tetramer interface [polypeptide binding]; other site
205921003013	putative DNA binding site [nucleotide binding]; other site
205921003014	Ca binding site [ion binding]; other site
205921003015	Ca binding site [ion binding]; other site
205921003016	Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413
205921003017	active site
205921003018	multimer interface [polypeptide binding]; other site
205921003019	GTP-binding protein LepA; Provisional; Region: PRK05433
205921003020	LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890
205921003021	G1 box; other site
205921003022	putative GEF interaction site [polypeptide binding]; other site
205921003023	GTP/Mg2+ binding site [chemical binding]; other site
205921003024	Switch I region; other site
205921003025	G2 box; other site
205921003026	G3 box; other site
205921003027	Switch II region; other site
205921003028	G4 box; other site
205921003029	G5 box; other site
205921003030	lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699
205921003031	lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane.   LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709
205921003032	GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421
205921003033	Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799
205921003034	Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond...; Region: LRR_RI; cl15309
205921003035	Substrate binding site [chemical binding]; other site
205921003036	Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799
205921003037	Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799
205921003038	Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799
205921003039	Predicted HD superfamily hydrolase [General function prediction only]; Region: COG1418
205921003040	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
205921003041	Zn2+ binding site [ion binding]; other site
205921003042	Mg2+ binding site [ion binding]; other site
205921003043	Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673
205921003044	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
205921003045	Coenzyme A binding pocket [chemical binding]; other site
205921003046	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632
205921003047	methionine sulfoxide reductase B; Provisional; Region: PRK00222
205921003048	SelR domain; Region: SelR; pfam01641
205921003049	Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; pfam00690
205921003050	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474
205921003051	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
205921003052	Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246
205921003053	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
205921003054	motif II; other site
205921003055	Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689
205921003056	Protein of unknown function (DUF2974); Region: DUF2974; pfam11187
205921003057	Xenobiotic acyltransferase (XAT): The XAT class of hexapeptide acyltransferases is composed of a large number of microbial enzymes that catalyze the CoA-dependent acetylation of a variety of hydroxyl-bearing acceptors such as chloramphenicol and...; Region: LbH_XAT; cd03349
205921003058	trimer interface [polypeptide binding]; other site
205921003059	active site
205921003060	substrate binding site [chemical binding]; other site
205921003061	CoA binding site [chemical binding]; other site
205921003062	Uncharacterized conserved protein [Function unknown]; Region: COG0398
205921003063	SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335
205921003064	ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555
205921003065	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
205921003066	Walker A/P-loop; other site
205921003067	ATP binding site [chemical binding]; other site
205921003068	Q-loop/lid; other site
205921003069	ABC transporter signature motif; other site
205921003070	Walker B; other site
205921003071	D-loop; other site
205921003072	H-loop/switch region; other site
205921003073	Predicted transcriptional regulators [Transcription]; Region: COG1725
205921003074	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
205921003075	DNA-binding site [nucleotide binding]; DNA binding site
205921003076	DNA polymerase III DnaE; Reviewed; Region: dnaE; PRK07279
205921003077	Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III; Region: PHP_PolIIIA; cd07431
205921003078	active site
205921003079	PHP Thumb interface [polypeptide binding]; other site
205921003080	DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485
205921003081	generic binding surface II; other site
205921003082	generic binding surface I; other site
205921003083	Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to a subfamily of the PFKA family (cd00363) and include bacterial ATP-dependent...; Region: Bacterial_PFK; cd00763
205921003084	6-phosphofructokinase; Region: PFKA_ATP; TIGR02482
205921003085	active site
205921003086	ADP/pyrophosphate binding site [chemical binding]; other site
205921003087	dimerization interface [polypeptide binding]; other site
205921003088	allosteric effector site; other site
205921003089	fructose-1,6-bisphosphate binding site; other site
205921003090	pyruvate kinase; Provisional; Region: PRK05826
205921003091	Pyruvate kinase (PK):  Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342
205921003092	domain interfaces; other site
205921003093	active site
205921003094	signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227
205921003095	Peptidase S24-like; Region: Peptidase_S24; pfam00717
205921003096	Catalytic site [active]
205921003097	The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530
205921003098	glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331
205921003099	Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans).  The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714
205921003100	glutaminase active site [active]
205921003101	SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008
205921003102	dimer interface [polypeptide binding]; other site
205921003103	active site
205921003104	SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009
205921003105	dimer interface [polypeptide binding]; other site
205921003106	active site
205921003107	Uncharacterized Zn-ribbon-containing protein involved in phosphonate metabolism [Inorganic ion transport and metabolism]; Region: PhnA; COG2824
205921003108	PhnA Zinc-Ribbon; Region: PhnA_Zn_Ribbon; pfam08274
205921003109	PhnA protein; Region: PhnA; pfam03831
205921003110	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
205921003111	dimer interface [polypeptide binding]; other site
205921003112	conserved gate region; other site
205921003113	putative PBP binding loops; other site
205921003114	ABC-ATPase subunit interface; other site
205921003115	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
205921003116	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
205921003117	Walker A/P-loop; other site
205921003118	ATP binding site [chemical binding]; other site
205921003119	Q-loop/lid; other site
205921003120	ABC transporter signature motif; other site
205921003121	Walker B; other site
205921003122	D-loop; other site
205921003123	H-loop/switch region; other site
205921003124	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
205921003125	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
205921003126	substrate binding pocket [chemical binding]; other site
205921003127	membrane-bound complex binding site; other site
205921003128	hinge residues; other site
205921003129	30S ribosomal protein S20; Reviewed; Region: rpsT; PRK00239
205921003130	pantothenate kinase; Provisional; Region: PRK05439
205921003131	Pantothenate kinase (PanK) catalyzes the phosphorylation of pantothenic acid to form 4'-phosphopantothenic, which is the first of five steps in coenzyme A (CoA) biosynthetic pathway. The reaction carried out by this enzyme is a key regulatory point...; Region: PanK; cd02025
205921003132	ATP-binding site [chemical binding]; other site
205921003133	CoA-binding site [chemical binding]; other site
205921003134	Mg2+-binding site [ion binding]; other site
205921003135	Methyltransferase domain; Region: Methyltransf_31; pfam13847
205921003136	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
205921003137	S-adenosylmethionine binding site [chemical binding]; other site
205921003138	Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283
205921003139	active site
205921003140	catalytic motif [active]
205921003141	Zn binding site [ion binding]; other site
205921003142	Uncharacterized ABC-type transport system, periplasmic component/surface lipoprotein [General function prediction only]; Region: Med; COG1744
205921003143	Periplasmic binding domain of basic membrane lipoprotein, PnrA, in Treponema pallidum and its homologs from other bacteria and Archaea; Region: PBP1_BmpA_PnrA_like; cd06354
205921003144	ligand binding site [chemical binding]; other site
205921003145	ABC-type uncharacterized transport systems, ATPase components [General function prediction only]; Region: COG3845
205921003146	First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216
205921003147	Walker A/P-loop; other site
205921003148	ATP binding site [chemical binding]; other site
205921003149	Q-loop/lid; other site
205921003150	ABC transporter signature motif; other site
205921003151	Walker B; other site
205921003152	D-loop; other site
205921003153	H-loop/switch region; other site
205921003154	Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215
205921003155	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
205921003156	Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580
205921003157	TM-ABC transporter signature motif; other site
205921003158	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
205921003159	Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580
205921003160	TM-ABC transporter signature motif; other site
205921003161	coenzyme A disulfide reductase; Reviewed; Region: PRK09564
205921003162	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
205921003163	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
205921003164	L-lactate dehydrogenase; Reviewed; Region: ldh; PRK00066
205921003165	L-2-hydroxyisocapronate dehydrogenases and some bacterial L-lactate dehydrogenases; Region: HicDH_like; cd05291
205921003166	tetramer (dimer of dimers) interface [polypeptide binding]; other site
205921003167	NAD binding site [chemical binding]; other site
205921003168	dimer interface [polypeptide binding]; other site
205921003169	substrate binding site [chemical binding]; other site
205921003170	DNA gyrase subunit A; Validated; Region: PRK05560
205921003171	DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187
205921003172	CAP-like domain; other site
205921003173	active site
205921003174	primary dimer interface [polypeptide binding]; other site
205921003175	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
205921003176	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
205921003177	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
205921003178	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
205921003179	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
205921003180	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
205921003181	Sortase A (SrtA) or subfamily-1 sortases are cysteine transpeptidases found in gram-positive bacteria that anchor surface proteins to peptidoglycans of the bacterial cell wall envelope. They do so by catalyzing a transpeptidation reaction in which the...; Region: Sortase_A_1; cd06165
205921003182	active site
205921003183	catalytic site [active]
205921003184	This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_1; cd08352
205921003185	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
205921003186	putative metal binding site [ion binding]; other site
205921003187	Predicted secreted protein [Function unknown]; Region: COG4086
205921003188	Protein of unknown function (DUF1002); Region: DUF1002; pfam06207
205921003189	Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475
205921003190	Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999
205921003191	DDE superfamily endonuclease; Region: DDE_4_2; pfam13613
205921003192	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3293
205921003193	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
205921003194	GMP synthase; Reviewed; Region: guaA; PRK00074
205921003195	Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742
205921003196	AMP/PPi binding site [chemical binding]; other site
205921003197	candidate oxyanion hole; other site
205921003198	catalytic triad [active]
205921003199	potential glutamine specificity residues [chemical binding]; other site
205921003200	The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997
205921003201	ATP Binding subdomain [chemical binding]; other site
205921003202	Dimerization subdomain; other site
205921003203	Transcriptional regulators [Transcription]; Region: PhnF; COG2188
205921003204	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
205921003205	DNA-binding site [nucleotide binding]; DNA binding site
205921003206	UTRA domain; Region: UTRA; pfam07702
205921003207	tRNA (uracil-5-)-methyltransferase Gid; Reviewed; Region: PRK05335
205921003208	Glucose inhibited division protein A; Region: GIDA; pfam01134
205921003209	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
205921003210	Coenzyme A binding pocket [chemical binding]; other site
205921003211	ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464
205921003212	NLPA lipoprotein; Region: Lipoprotein_9; pfam03180
205921003213	PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577
205921003214	C-terminal processing peptidase family S41; Region: Peptidase_S41; cd06567
205921003215	Active site serine [active]
205921003216	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
205921003217	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
205921003218	Walker A/P-loop; other site
205921003219	ATP binding site [chemical binding]; other site
205921003220	Q-loop/lid; other site
205921003221	ABC transporter signature motif; other site
205921003222	Walker B; other site
205921003223	D-loop; other site
205921003224	H-loop/switch region; other site
205921003225	FtsX-like permease family; Region: FtsX; pfam02687
205921003226	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
205921003227	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
205921003228	active site
205921003229	phosphorylation site [posttranslational modification]
205921003230	intermolecular recognition site; other site
205921003231	dimerization interface [polypeptide binding]; other site
205921003232	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
205921003233	DNA binding site [nucleotide binding]
205921003234	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
205921003235	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
205921003236	ATP binding site [chemical binding]; other site
205921003237	Mg2+ binding site [ion binding]; other site
205921003238	G-X-G motif; other site
205921003239	site-specific tyrosine recombinase XerS; Reviewed; Region: xerS; PRK05084
205921003240	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
205921003241	active site
205921003242	DNA binding site [nucleotide binding]
205921003243	Int/Topo IB signature motif; other site
205921003244	ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166
205921003245	The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504
205921003246	peptide binding site [polypeptide binding]; other site
205921003247	Protein of unknown function (DUF3307); Region: DUF3307; pfam11750
205921003248	signal recognition particle protein; Provisional; Region: PRK10867
205921003249	SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963
205921003250	The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115
205921003251	P loop; other site
205921003252	GTP binding site [chemical binding]; other site
205921003253	Signal peptide binding domain; Region: SRP_SPB; pfam02978
205921003254	putative DNA-binding protein; Validated; Region: PRK00118
205921003255	Putative helix-turn-helix protein, YlxM / p13 like; Region: UPF0122; pfam04297
205921003256	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
205921003257	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
205921003258	dimer interface [polypeptide binding]; other site
205921003259	phosphorylation site [posttranslational modification]
205921003260	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
205921003261	ATP binding site [chemical binding]; other site
205921003262	Mg2+ binding site [ion binding]; other site
205921003263	G-X-G motif; other site
205921003264	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
205921003265	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
205921003266	active site
205921003267	phosphorylation site [posttranslational modification]
205921003268	intermolecular recognition site; other site
205921003269	dimerization interface [polypeptide binding]; other site
205921003270	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
205921003271	DNA binding site [nucleotide binding]
205921003272	Peptidase M1 Aminopeptidase N family incudes tricorn interacting factor F3, Endoplasmic reticulum aminopeptidase 1 (ERAP1), Aminopeptidase Q (APQ); Region: M1_APN_2; cd09601
205921003273	Aminopeptidase N [Amino acid transport and metabolism]; Region: PepN; COG0308
205921003274	Zn binding site [ion binding]; other site
205921003275	phosphate transport system regulatory protein PhoU; Region: phoU_full; TIGR02135
205921003276	PhoU domain; Region: PhoU; pfam01895
205921003277	PhoU domain; Region: PhoU; pfam01895
205921003278	ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260
205921003279	Q-loop/lid; other site
205921003280	ABC transporter signature motif; other site
205921003281	Walker B; other site
205921003282	D-loop; other site
205921003283	H-loop/switch region; other site
205921003284	phosphate transporter ATP-binding protein; Provisional; Region: PRK14237
205921003285	ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260
205921003286	Walker A/P-loop; other site
205921003287	ATP binding site [chemical binding]; other site
205921003288	Q-loop/lid; other site
205921003289	ABC transporter signature motif; other site
205921003290	Walker B; other site
205921003291	D-loop; other site
205921003292	H-loop/switch region; other site
205921003293	ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstA; COG0581
205921003294	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
205921003295	dimer interface [polypeptide binding]; other site
205921003296	conserved gate region; other site
205921003297	putative PBP binding loops; other site
205921003298	ABC-ATPase subunit interface; other site
205921003299	ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstC; COG0573
205921003300	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
205921003301	dimer interface [polypeptide binding]; other site
205921003302	conserved gate region; other site
205921003303	putative PBP binding loops; other site
205921003304	ABC-ATPase subunit interface; other site
205921003305	PBP superfamily domain; Region: PBP_like_2; cl17296
205921003306	Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531
205921003307	rRNA (cytosine-C(5)-)-methyltransferase RsmF; Reviewed; Region: yebU; PRK11933
205921003308	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
205921003309	S-adenosylmethionine binding site [chemical binding]; other site
205921003310	pre-rRNA processing and ribosome biogenesis; Region: Nol1_Nop2_Fmu_2; pfam13636
205921003311	Inositol-monophosphatase-like domains. This family of phosphatases is dependent on bivalent metal ions such as Mg++, and many members are inhibited by Li+ (which is thought to displace a bivalent ion in the active site). Substrates include fructose-1; Region: IMPase_like; cd01637
205921003312	Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483
205921003313	active site
205921003314	hypothetical protein; Provisional; Region: PRK04387
205921003315	Arsenate Reductase (ArsC) family, Spx subfamily; Spx is a unique RNA polymerase (RNAP)-binding protein present in bacilli and some mollicutes. It inhibits transcription by binding to the C-terminal domain of the alpha subunit of RNAP, disrupting complex...; Region: ArsC_Spx; cd03032
205921003316	ArsC family; Region: ArsC; pfam03960
205921003317	putative catalytic residues [active]
205921003318	thiol/disulfide switch; other site
205921003319	bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627
205921003320	FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064
205921003321	active site
205921003322	Riboflavin kinase; Region: Flavokinase; smart00904
205921003323	tRNA pseudouridine synthase B; Provisional; Region: truB; PRK02484
205921003324	Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573
205921003325	RNA binding site [nucleotide binding]; other site
205921003326	active site
205921003327	tRNA Pseudouridine synthase II, C terminal; Region: TruB_C; pfam09142
205921003328	Acetyltransferase (GNAT) domain; Region: Acetyltransf_4; pfam13420
205921003329	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
205921003330	Coenzyme A binding pocket [chemical binding]; other site
205921003331	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4487
205921003332	Uncharacterized protein conserved in bacteria (DUF2130); Region: DUF2130; pfam09903
205921003333	Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420
205921003334	CAAX protease self-immunity; Region: Abi; pfam02517
205921003335	FtsX-like permease family; Region: FtsX; pfam02687
205921003336	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
205921003337	ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577
205921003338	FtsX-like permease family; Region: FtsX; pfam02687
205921003339	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
205921003340	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
205921003341	Walker A/P-loop; other site
205921003342	ATP binding site [chemical binding]; other site
205921003343	Q-loop/lid; other site
205921003344	ABC transporter signature motif; other site
205921003345	Walker B; other site
205921003346	D-loop; other site
205921003347	H-loop/switch region; other site
205921003348	DNA topoisomerase I; Validated; Region: PRK05582
205921003349	TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I.   Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363
205921003350	active site
205921003351	interdomain interaction site; other site
205921003352	putative metal-binding site [ion binding]; other site
205921003353	nucleotide binding site [chemical binding]; other site
205921003354	DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186
205921003355	domain I; other site
205921003356	DNA binding groove [nucleotide binding]
205921003357	phosphate binding site [ion binding]; other site
205921003358	domain II; other site
205921003359	domain III; other site
205921003360	nucleotide binding site [chemical binding]; other site
205921003361	catalytic site [active]
205921003362	domain IV; other site
205921003363	Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396
205921003364	Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396
205921003365	DNA recombination-mediator protein A; Region: DNA_processg_A; pfam02481
205921003366	DNA protecting protein DprA; Region: dprA; TIGR00732
205921003367	Siderophore binding protein FatB.  These proteins have been shown to function as ABC-type initial receptors in the siderophore-mediated iron uptake in some eubacterial species.  They belong to the TroA superfamily of periplasmic metal binding proteins...; Region: FatB; cd01140
205921003368	putative ligand binding residues [chemical binding]; other site
205921003369	Periplasmic binding protein; Region: Peripla_BP_2; pfam01497
205921003370	ABC-type enterochelin transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CeuD; COG4604
205921003371	ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214
205921003372	Walker A/P-loop; other site
205921003373	ATP binding site [chemical binding]; other site
205921003374	Q-loop/lid; other site
205921003375	ABC transporter signature motif; other site
205921003376	Walker B; other site
205921003377	D-loop; other site
205921003378	H-loop/switch region; other site
205921003379	iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577
205921003380	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
205921003381	ABC-ATPase subunit  interface; other site
205921003382	dimer interface [polypeptide binding]; other site
205921003383	putative PBP binding regions; other site
205921003384	iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577
205921003385	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
205921003386	ABC-ATPase subunit  interface; other site
205921003387	dimer interface [polypeptide binding]; other site
205921003388	putative PBP binding regions; other site
205921003389	maltose O-acetyltransferase; Provisional; Region: PRK10092
205921003390	Maltose O-acetyltransferase (MAT) and Galactoside O-acetyltransferase (GAT): MAT and GAT catalyze the CoA-dependent acetylation of the 6-hydroxyl group of their respective sugar substrates. MAT acetylates maltose and glucose exclusively at the C6...; Region: LbH_MAT_GAT; cd03357
205921003391	active site
205921003392	substrate binding site [chemical binding]; other site
205921003393	trimer interface [polypeptide binding]; other site
205921003394	CoA binding site [chemical binding]; other site
205921003395	bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182
205921003396	RNA/DNA hybrid binding site [nucleotide binding]; other site
205921003397	active site
205921003398	GTPase YlqF; Reviewed; Region: rbgA; PRK09563
205921003399	Circularly permuted YlqF GTPase; Region: YlqF; cd01856
205921003400	GTP/Mg2+ binding site [chemical binding]; other site
205921003401	G4 box; other site
205921003402	G5 box; other site
205921003403	Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170
205921003404	G1 box; other site
205921003405	G1 box; other site
205921003406	GTP/Mg2+ binding site [chemical binding]; other site
205921003407	Switch I region; other site
205921003408	G2 box; other site
205921003409	G2 box; other site
205921003410	G3 box; other site
205921003411	G3 box; other site
205921003412	Switch II region; other site
205921003413	Switch II region; other site
205921003414	G5 box; other site
205921003415	L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734
205921003416	Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376
205921003417	Carbon starvation protein, predicted membrane protein [Signal transduction mechanisms]; Region: CstA; COG1966
205921003418	Carbon starvation protein CstA; Region: CstA; pfam02554
205921003419	C-terminal domain on CstA (DUF4161); Region: DUF4161; pfam13722
205921003420	two-component response regulator; Provisional; Region: PRK14084
205921003421	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
205921003422	active site
205921003423	phosphorylation site [posttranslational modification]
205921003424	intermolecular recognition site; other site
205921003425	dimerization interface [polypeptide binding]; other site
205921003426	LytTr DNA-binding domain; Region: LytTR; pfam04397
205921003427	Putative regulator of cell autolysis [Signal transduction mechanisms]; Region: LytS; COG3275
205921003428	5TMR of 5TMR-LYT; Region: 5TM-5TMR_LYT; pfam07694
205921003429	GAF domain; Region: GAF_3; pfam13492
205921003430	Histidine kinase; Region: His_kinase; pfam06580
205921003431	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
205921003432	Mg2+ binding site [ion binding]; other site
205921003433	G-X-G motif; other site
205921003434	Domain of unknown function (DUF4176); Region: DUF4176; pfam13780
205921003435	Domain of unknown function (DUF4176); Region: DUF4176; pfam13780
205921003436	type VII secretion effector, SACOL2603 family; Region: T7SS_SACOL2603; TIGR04197
205921003437	DNA transporter; Region: FtsK_SpoIIIE_N; pfam12538
205921003438	RNA recognition motif (RRM) superfamily; Region: RRM_SF; cl17169
205921003439	type VII secretion protein EssC, C-terminal domain; Region: T7_EssCb_Firm; TIGR03928
205921003440	FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580
205921003441	FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580
205921003442	type VII secretion protein EssB; Region: T7_EssB; TIGR03926
205921003443	WXG100 protein secretion system (Wss), protein YukC; Region: YukC; pfam10140
205921003444	WXG100 protein secretion system (Wss), protein YukD; Region: YukD; pfam08817
205921003445	type VII secretion protein EssA; Region: T7SS_EssA_Firm; TIGR03927
205921003446	type VII secretion protein EsaA, N-terminal domain; Region: T7_esaA_Nterm; TIGR03929
205921003447	YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061
205921003448	WXG100 family type VII secretion target; Region: WXG100_ESAT6; TIGR03930
205921003449	WXG100 family type VII secretion target; Region: WXG100_ESAT6; TIGR03930
205921003450	Protein of unknown function (DUF2974); Region: DUF2974; pfam11187
205921003451	Lipase.  Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is "interfacial activation", the process of...; Region: Lipase; cl14883
205921003452	nucleophilic elbow; other site
205921003453	catalytic triad; other site
205921003454	carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294
205921003455	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
205921003456	Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786
205921003457	Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787
205921003458	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
205921003459	ATP-grasp domain; Region: ATP-grasp_4; cl17255
205921003460	Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424
205921003461	IMP binding site; other site
205921003462	dimer interface [polypeptide binding]; other site
205921003463	interdomain contacts; other site
205921003464	partial ornithine binding site; other site
205921003465	carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564
205921003466	Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; smart01097
205921003467	Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744
205921003468	catalytic site [active]
205921003469	subunit interface [polypeptide binding]; other site
205921003470	aspartate carbamoyltransferase catalytic subunit; Provisional; Region: pyrB; PRK00856
205921003471	Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729
205921003472	Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185
205921003473	dihydroorotase; Validated; Region: pyrC; PRK09357
205921003474	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
205921003475	Dihydroorotase (DHOase), subgroup IIa; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This subgroup also contains proteins that lack the active site, like unc-33, a C; Region: DHOase_IIa; cd01317
205921003476	active site
205921003477	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
205921003478	active site
205921003479	Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725
205921003480	active site
205921003481	dimer interface [polypeptide binding]; other site
205921003482	Uncharacterized conserved protein [Function unknown]; Region: COG2966
205921003483	Protein of unknown function (DUF1212); Region: DUF1212; pfam06738
205921003484	Protein of unknown function (DUF3815); Region: DUF3815; pfam12821
205921003485	ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488
205921003486	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
205921003487	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
205921003488	ABC transporter; Region: ABC_tran_2; pfam12848
205921003489	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
205921003490	ATP cone domain; Region: ATP-cone; pfam03477
205921003491	aspartate-semialdehyde dehydrogenase; Provisional; Region: PRK14874
205921003492	Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859
205921003493	KxYKxGKxW signal peptide; Region: KxYKxGKxW; TIGR03715
205921003494	Fibrinogen binding protein; Region: Fibrinogen_BP; pfam08017
205921003495	LPXTG-motif cell wall anchor domain; Region: LPXTG_anchor; TIGR01167
205921003496	cardiolipin synthetase; Reviewed; Region: cls; PRK01642
205921003497	Putative catalytic domain, repeat 1, of Streptococcus mutans uncharacterized protein SMU_988 and similar proteins; Region: PLDc_SMU_988_like_1; cd09154
205921003498	putative active site [active]
205921003499	catalytic site [active]
205921003500	Putative catalytic domain, repeat 2, of Streptococcus mutans uncharacterized protein SMU_988 and similar proteins; Region: PLDc_SMU_988_like_2; cd09160
205921003501	putative active site [active]
205921003502	catalytic site [active]
205921003503	formate--tetrahydrofolate ligase; Provisional; Region: PRK13505
205921003504	Formyltetrahydrofolate synthetase (FTHFS) catalyzes the ATP-dependent activation of formate ion via its addition to the N10 position of tetrahydrofolate. FTHFS is a highly expressed key enzyme in both the Wood-Ljungdahl pathway of autotrophic CO2...; Region: FTHFS; cd00477
205921003505	Potassium binding sites [ion binding]; other site
205921003506	Cesium cation binding sites [ion binding]; other site
205921003507	Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095
205921003508	lipoyltransferase and lipoate-protein ligase; Region: lipoyltrans; TIGR00545
205921003509	Bacterial lipoate protein ligase C-terminus; Region: Lip_prot_lig_C; pfam10437
205921003510	NAD-dependent protein deacetylases, SIR2 family [Transcription]; Region: SIR2; COG0846
205921003511	SIR2 superfamily of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+; Region: SIR2; cl00195
205921003512	hypothetical protein; Provisional; Region: PRK04143
205921003513	ADP-ribose binding site [chemical binding]; other site
205921003514	Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848
205921003515	lipoyl attachment site [posttranslational modification]; other site
205921003516	Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cd00347
205921003517	luciferase family oxidoreductase, group 1; Region: oxido_grp_1; TIGR03558
205921003518	probable F420-dependent oxidoreductase, MSMEG_4141 family; Region: F420_MSMEG_4141; TIGR03620
205921003519	NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902
205921003520	Old yellow enzyme (OYE)-related FMN binding domain, group 4.  Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a reducing agent with oxygens, quinones, and alpha,beta-unsaturated aldehydes and ketones, and can act as...; Region: OYE_like_4_FMN; cd04735
205921003521	putative active site [active]
205921003522	putative FMN binding site [chemical binding]; other site
205921003523	putative substrate binding site [chemical binding]; other site
205921003524	putative catalytic residue [active]
205921003525	Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095
205921003526	phosphopantothenate--cysteine ligase; Validated; Region: PRK06732
205921003527	phosphopantothenoylcysteine decarboxylase, streptococcal; Region: coaC_strep; TIGR02113
205921003528	Flavoprotein; Region: Flavoprotein; pfam02441
205921003529	Predicted membrane protein [Function unknown]; Region: COG4684
205921003530	phosphoglucomutase-2-like protein; Provisional; Region: PTZ00150
205921003531	This CD includes PGM2 (phosphoglucomutase 2) and PGM2L1 (phosphoglucomutase 2-like 1). The mammalian PGM2 is thought to be a phosphopentomutase that catalyzes the conversion of the nucleoside breakdown products, ribose-1-phosphate and...; Region: PGM2; cd05799
205921003532	active site
205921003533	substrate binding site [chemical binding]; other site
205921003534	metal binding site [ion binding]; metal-binding site
205921003535	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
205921003536	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
205921003537	ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254
205921003538	Walker A/P-loop; other site
205921003539	ATP binding site [chemical binding]; other site
205921003540	Q-loop/lid; other site
205921003541	ABC transporter signature motif; other site
205921003542	Walker B; other site
205921003543	D-loop; other site
205921003544	H-loop/switch region; other site
205921003545	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
205921003546	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
205921003547	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
205921003548	Walker A/P-loop; other site
205921003549	ATP binding site [chemical binding]; other site
205921003550	Q-loop/lid; other site
205921003551	ABC transporter signature motif; other site
205921003552	Walker B; other site
205921003553	D-loop; other site
205921003554	H-loop/switch region; other site
205921003555	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
205921003556	N-acetyl-D-glucosamine binding site [chemical binding]; other site
205921003557	catalytic residue [active]
205921003558	37-kD nucleoid-associated bacterial protein; Region: NA37; pfam04245
205921003559	serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011
205921003560	Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378
205921003561	dimer interface [polypeptide binding]; other site
205921003562	active site
205921003563	glycine-pyridoxal phosphate binding site [chemical binding]; other site
205921003564	folate binding site [chemical binding]; other site
205921003565	Putative translation factor (SUA5) [Translation, ribosomal structure and biogenesis]; Region: SUA5; COG0009
205921003566	N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328
205921003567	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
205921003568	S-adenosylmethionine binding site [chemical binding]; other site
205921003569	peptide chain release factor 1; Validated; Region: prfA; PRK00591
205921003570	This domain is found in peptide chain release factors; Region: PCRF; smart00937
205921003571	RF-1 domain; Region: RF-1; pfam00472
205921003572	thymidine kinase; Provisional; Region: PRK04296
205921003573	4-oxalocrotonate tautomerase; Provisional; Region: PRK02289
205921003574	active site 1 [active]
205921003575	dimer interface [polypeptide binding]; other site
205921003576	hexamer interface [polypeptide binding]; other site
205921003577	active site 2 [active]
205921003578	Membrane-associated lipoprotein involved in thiamine biosynthesis [Coenzyme metabolism]; Region: ApbE; COG1477
205921003579	ApbE family; Region: ApbE; pfam02424
205921003580	Predicted flavoprotein [General function prediction only]; Region: COG0431
205921003581	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
205921003582	Predicted flavoprotein [General function prediction only]; Region: COG0431
205921003583	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
205921003584	PAS domain; Region: PAS_10; pfam13596
205921003585	Formate/nitrite transporter; Region: Form_Nir_trans; cl00927
205921003586	xanthine permease; Region: pbuX; TIGR03173
205921003587	Sulfate transporter family; Region: Sulfate_transp; pfam00916
205921003588	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
205921003589	active site
205921003590	guanosine 5'-monophosphate oxidoreductase; Provisional; Region: PRK05458
205921003591	IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381
205921003592	active site
205921003593	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
205921003594	Major Facilitator Superfamily; Region: MFS_1; pfam07690
205921003595	putative substrate translocation pore; other site
205921003596	K+ potassium transporter; Region: K_trans; cl15781
205921003597	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
205921003598	malonic semialdehyde reductase; Provisional; Region: PRK10538
205921003599	NAD(P) binding site [chemical binding]; other site
205921003600	active site
205921003601	phosphotransacetylase; Reviewed; Region: eutD; PRK09653
205921003602	Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564
205921003603	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cl09940
205921003604	RNA binding surface [nucleotide binding]; other site
205921003605	Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869
205921003606	active site
205921003607	inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK04885
205921003608	ATP-NAD kinase; Region: NAD_kinase; pfam01513
205921003609	Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399
205921003610	synthetase active site [active]
205921003611	NTP binding site [chemical binding]; other site
205921003612	metal binding site [ion binding]; metal-binding site
205921003613	Uncharacterized subgroup 1 of the CYTH-like superfamily; Region: CYTH-like_Pase_1; cd07762
205921003614	putative active site [active]
205921003615	putative metal binding residues [ion binding]; other site
205921003616	signature motif; other site
205921003617	putative triphosphate binding site [ion binding]; other site
205921003618	ribose-phosphate pyrophosphokinase; Provisional; Region: PRK02458
205921003619	N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793
205921003620	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
205921003621	active site
205921003622	Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104
205921003623	cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402
205921003624	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
205921003625	catalytic residue [active]
205921003626	Putative amino acid metabolism; Region: DUF1831; pfam08866
205921003627	redox-sensing transcriptional repressor Rex; Provisional; Region: PRK05472
205921003628	Putative DNA-binding protein N-terminus; Region: Put_DNA-bind_N; pfam06971
205921003629	CoA binding domain; Region: CoA_binding; pfam02629
205921003630	hypothetical protein; Reviewed; Region: PRK00024
205921003631	Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071
205921003632	MPN+ (JAMM) motif; other site
205921003633	Zinc-binding site [ion binding]; other site
205921003634	Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628
205921003635	6-phospho-beta-glucosidase; Reviewed; Region: arb; PRK09593
205921003636	beta-galactosidase; Region: BGL; TIGR03356
205921003637	NnaC (CMP-NeuNAc synthetase) _like subfamily of SGNH_hydrolases, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its...; Region: NnaC_like; cd01841
205921003638	active site
205921003639	catalytic triad [active]
205921003640	oxyanion hole [active]
205921003641	haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282
205921003642	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
205921003643	active site
205921003644	motif I; other site
205921003645	haloacid dehalogenase-like hydrolase; Region: HAD; cl17202
205921003646	AraC-like ligand binding domain; Region: AraC_binding; pfam02311
205921003647	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
205921003648	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
205921003649	Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038
205921003650	ClC chloride channel EriC.  This domain is found in the EriC chloride transporters that mediate the extreme acid resistance response in eubacteria and archaea. This response allows bacteria to survive in the acidic environments by decarboxylation-linked...; Region: EriC; cd01031
205921003651	Cl- selectivity filter; other site
205921003652	Cl- binding residues [ion binding]; other site
205921003653	pore gating glutamate residue; other site
205921003654	dimer interface [polypeptide binding]; other site
205921003655	H+/Cl- coupling transport residue; other site
205921003656	TrkA-C domain; Region: TrkA_C; pfam02080
205921003657	Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687
205921003658	Bacterial extracellular solute-binding protein; Region: SBP_bac_6; pfam13343
205921003659	ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177
205921003660	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
205921003661	dimer interface [polypeptide binding]; other site
205921003662	conserved gate region; other site
205921003663	putative PBP binding loops; other site
205921003664	ABC-ATPase subunit interface; other site
205921003665	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
205921003666	dimer interface [polypeptide binding]; other site
205921003667	conserved gate region; other site
205921003668	putative PBP binding loops; other site
205921003669	ABC-ATPase subunit interface; other site
205921003670	ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842
205921003671	ATP-binding cassette domain of the polyamine transporter; Region: ABC_PotA_N; cd03300
205921003672	Walker A/P-loop; other site
205921003673	ATP binding site [chemical binding]; other site
205921003674	Q-loop/lid; other site
205921003675	ABC transporter signature motif; other site
205921003676	Walker B; other site
205921003677	D-loop; other site
205921003678	H-loop/switch region; other site
205921003679	TOBE domain; Region: TOBE_2; pfam08402
205921003680	UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK13905
205921003681	FAD binding domain; Region: FAD_binding_4; pfam01565
205921003682	UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873
205921003683	7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483
205921003684	catalytic center binding site [active]
205921003685	ATP binding site [chemical binding]; other site
205921003686	Dihydroneopterin aldolase (DHNA) and 7,8-dihydroneopterin triphosphate epimerase domain (DHNTPE); these enzymes have been designated folB and folX, respectively. Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and...; Region: DHNA_DHNTPE; cd00534
205921003687	homooctamer interface [polypeptide binding]; other site
205921003688	active site
205921003689	dihydropteroate synthase; Region: DHPS; TIGR01496
205921003690	DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739
205921003691	substrate binding pocket [chemical binding]; other site
205921003692	dimer interface [polypeptide binding]; other site
205921003693	inhibitor binding site; inhibition site
205921003694	GTP cyclohydrolase I (GTP-CH-I) catalyzes the conversion of GTP into dihydroneopterin triphosphate.  The enzyme product is the precursor of tetrahydrofolate in eubacteria, fungi, and plants and of the folate analogs in methanogenic bacteria.  In...; Region: GTP_cyclohydro1; cd00642
205921003695	homodecamer interface [polypeptide binding]; other site
205921003696	GTP cyclohydrolase I; Provisional; Region: PLN03044
205921003697	active site
205921003698	putative catalytic site residues [active]
205921003699	zinc binding site [ion binding]; other site
205921003700	GTP-CH-I/GFRP interaction surface; other site
205921003701	folylpolyglutamate synthase/dihydrofolate synthase; Region: folC; TIGR01499
205921003702	SNF2 Helicase protein; Region: DUF3670; pfam12419
205921003703	Predicted permeases [General function prediction only]; Region: RarD; COG2962
205921003704	homoserine kinase; Provisional; Region: PRK01212
205921003705	GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288
205921003706	homoserine dehydrogenase; Provisional; Region: PRK06349
205921003707	Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447
205921003708	Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742
205921003709	Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726
205921003710	Putative catalytic NodB homology domain of PgaB, IcaB, and similar proteins which consist of a deformed (beta/alpha)8 barrel fold with 5- or 6-strands; Region: CE4_NodB_like_5s_6s; cd10918
205921003711	putative active site [active]
205921003712	putative metal binding site [ion binding]; other site
205921003713	BCCT family transporter; Region: BCCT; pfam02028
205921003714	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3293
205921003715	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
205921003716	DDE superfamily endonuclease; Region: DDE_4_2; pfam13613
205921003717	NAD-dependent aldehyde dehydrogenases [Energy production and conversion]; Region: PutA; COG1012
205921003718	Mycobacterium tuberculosis succinate-semialdehyde dehydrogenase 1-like; Region: ALDH_SSADH1_GabD1; cd07100
205921003719	NAD(P) binding site [chemical binding]; other site
205921003720	catalytic residues [active]
205921003721	Predicted membrane protein [Function unknown]; Region: COG2855
205921003722	similar to DNA-binding protein; identified by match to protein family HMM PF01381
205921003723	Protein of unknown function (DUF3278); Region: DUF3278; pfam11683
205921003724	Peroxiredoxin (PRX) family, Atypical 2-cys PRX subfamily; composed of PRXs containing peroxidatic and resolving cysteines, similar to the homodimeric thiol specific antioxidant (TSA) protein also known as TRX-dependent thiol peroxidase (Tpx). Tpx is a...; Region: PRX_Atyp2cys; cd03014
205921003725	dimer interface [polypeptide binding]; other site
205921003726	catalytic triad [active]
205921003727	peroxidatic and resolving cysteines [active]
205921003728	DNA alkylation repair enzyme; Region: DNA_alkylation; pfam08713
205921003729	A new structural DNA glycosylase containing HEAT-like repeats; Region: AlkD_like_1; cd07064
205921003730	active site
205921003731	Transcriptional regulators [Transcription]; Region: PhnF; COG2188
205921003732	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
205921003733	DNA-binding site [nucleotide binding]; DNA binding site
205921003734	TrkA-C domain; Region: TrkA_C; pfam02080
205921003735	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1302
205921003736	CsbD-like; Region: CsbD; pfam05532
205921003737	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1302
205921003738	Small integral membrane protein [Function unknown]; Region: COG5547
205921003739	Predicted membrane protein [Function unknown]; Region: COG2261
205921003740	Predicted membrane protein [Function unknown]; Region: COG2261
205921003741	ATP-dependent DNA helicase PcrA; Region: pcrA; TIGR01073
205921003742	Part of AAA domain; Region: AAA_19; pfam13245
205921003743	AAA domain; Region: AAA_12; pfam13087
205921003744	Family description; Region: UvrD_C_2; pfam13538
205921003745	PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria.  Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443
205921003746	CoenzymeA binding site [chemical binding]; other site
205921003747	subunit interaction site [polypeptide binding]; other site
205921003748	PHB binding site; other site
205921003749	uracil transporter; Provisional; Region: PRK10720
205921003750	Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115
205921003751	amino acid carrier protein; Region: agcS; TIGR00835
205921003752	Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053
205921003753	Cation efflux family; Region: Cation_efflux; pfam01545
205921003754	Putative effector of murein hydrolase LrgA [General function prediction only]; Region: COG1380
205921003755	LrgB-like family; Region: LrgB; pfam04172
205921003756	Domain of Unknown Function with PDB structure (DUF3862); Region: DUF3862; pfam12978
205921003757	30S ribosomal protein S1; Reviewed; Region: rpsA; PRK06676
205921003758	S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687
205921003759	RNA binding site [nucleotide binding]; other site
205921003760	S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465
205921003761	RNA binding site [nucleotide binding]; other site
205921003762	S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927
205921003763	RNA binding site [nucleotide binding]; other site
205921003764	S1_RPS1_repeat_hs4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_hs4; cd05692
205921003765	RNA binding site [nucleotide binding]; other site
205921003766	Protein of unknown function (DUF2969); Region: DUF2969; pfam11184
205921003767	branched-chain amino acid aminotransferase; Provisional; Region: PRK13357
205921003768	BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids  leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557
205921003769	homodimer interface [polypeptide binding]; other site
205921003770	substrate-cofactor binding pocket; other site
205921003771	catalytic residue [active]
205921003772	DNA topoisomerase IV, A subunit, Gram-positive; Region: parC_Gpos; TIGR01061
205921003773	DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187
205921003774	CAP-like domain; other site
205921003775	active site
205921003776	primary dimer interface [polypeptide binding]; other site
205921003777	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
205921003778	DNA topoisomerase IV, B subunit, Gram-positive; Region: parE_Gpos; TIGR01058
205921003779	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
205921003780	Mg2+ binding site [ion binding]; other site
205921003781	G-X-G motif; other site
205921003782	TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822
205921003783	anchoring element; other site
205921003784	dimer interface [polypeptide binding]; other site
205921003785	ATP binding site [chemical binding]; other site
205921003786	TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366
205921003787	active site
205921003788	putative metal-binding site [ion binding]; other site
205921003789	DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986
205921003790	putative glycerol-3-phosphate acyltransferase PlsY; Provisional; Region: PRK00220
205921003791	Family 1 of Uracil-DNA glycosylase (UDG) enzymes; Region: UDG_F1; cd10027
205921003792	ligand binding site [chemical binding]; other site
205921003793	active site
205921003794	UGI interface [polypeptide binding]; other site
205921003795	catalytic site [active]
205921003796	CMP-NeuAc_Synthase activates N-acetylneuraminic acid by adding CMP moiety; Region: CMP-NeuAc_Synthase; cd02513
205921003797	ligand binding site; other site
205921003798	tetramer interface; other site
205921003799	SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053
205921003800	active site
205921003801	catalytic triad [active]
205921003802	oxyanion hole [active]
205921003803	Putative Acyltransferase (AT), Left-handed parallel beta-Helix (LbH) domain; This group is composed of mostly uncharacterized proteins containing an N-terminal helical subdomain followed by a LbH domain. The alignment contains 6 turns, each containing...; Region: LbH_AT_putative; cd03360
205921003804	sugar O-acyltransferase, sialic acid O-acetyltransferase NeuD family; Region: NeuD_NnaD; TIGR03570
205921003805	putative trimer interface [polypeptide binding]; other site
205921003806	putative CoA binding site [chemical binding]; other site
205921003807	UDP-N-acetyl-D-glucosamine 2-epimerase, UDP-hydrolysing; Region: NeuC_NnaA; TIGR03568
205921003808	Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase  family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786
205921003809	active site
205921003810	homodimer interface [polypeptide binding]; other site
205921003811	N-acetylneuraminate synthase; Region: NeuB_NnaB; TIGR03569
205921003812	NeuB family; Region: NeuB; pfam03102
205921003813	C-terminal SAF domain of sialic acid synthetase; Region: SAF_NeuB_like; cd11615
205921003814	NeuB binding interface [polypeptide binding]; other site
205921003815	putative substrate binding site [chemical binding]; other site
205921003816	Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244
205921003817	Polysaccharide biosynthesis protein; Region: Polysacc_synt; pfam01943
205921003818	Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326
205921003819	Glycosyltransferase family 52; Region: Glyco_transf_52; pfam07922
205921003820	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761
205921003821	active site
205921003822	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
205921003823	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761
205921003824	active site
205921003825	O-antigen ligase like membrane protein; Region: O-antigen_lig; pfam13425
205921003826	Glycosyltransferase family 28 C-terminal domain; Region: Glyco_tran_28_C; pfam04101
205921003827	Oligosaccharide biosynthesis protein Alg14 like; Region: Alg14; pfam08660
205921003828	exopolysaccharide biosynthesis polyprenyl glycosylphosphotransferase; Region: EPS_sugtrans; TIGR03025
205921003829	Bacterial sugar transferase; Region: Bac_transf; pfam02397
205921003830	capsular exopolysaccharide family; Region: eps_fam; TIGR01007
205921003831	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
205921003832	Chain length determinant protein; Region: Wzz; cl15801
205921003833	Capsular polysaccharide biosynthesis protein [Cell envelope biogenesis, outer membrane]; Region: COG3944
205921003834	Capsular polysaccharide biosynthesis protein [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: CapC; COG4464
205921003835	DNA polymerase processivity factor; Region: DNA_PPF; pfam02916
205921003836	Cell envelope-related transcriptional attenuator domain; Region: LytR_cpsA_psr; pfam03816
205921003837	Transcriptional regulator [Transcription]; Region: LysR; COG0583
205921003838	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
205921003839	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
205921003840	dimerization interface [polypeptide binding]; other site
205921003841	purine nucleoside phosphorylase; Reviewed; Region: deoD; PRK05819
205921003842	Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038
205921003843	Putative ClC chloride channel.  Clc proteins are putative halogen ion (Cl-, Br- and I-) transporters found in eubacteria. They belong to the ClC superfamily of halogen ion channels, which share a unique double-barreled architecture and voltage-dependent...; Region: ClC_like; cd01033
205921003844	putative ion selectivity filter; other site
205921003845	putative pore gating glutamate residue; other site
205921003846	purine nucleoside phosphorylase; Provisional; Region: PRK08202
205921003847	Arsenate Reductase (ArsC) family, ArsC subfamily; arsenic reductases similar to that encoded by arsC on the R733 plasmid of Escherichia coli. E. coli ArsC catalyzes the reduction of arsenate [As(V)] to arsenite [As(III)], the first step in the...; Region: ArsC_ArsC; cd03034
205921003848	ArsC family; Region: ArsC; pfam03960
205921003849	catalytic residues [active]
205921003850	phosphopentomutase; Provisional; Region: PRK05362
205921003851	Metalloenzyme superfamily; Region: Metalloenzyme; pfam01676
205921003852	RPI_A: Ribose 5-phosphate isomerase type A (RPI_A) subfamily; RPI catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate, the first step of the non-oxidative branch of the pentose phosphate pathway. This reaction leads to the...; Region: RPI_A; cd01398
205921003853	tetramer (dimer of dimers) interface [polypeptide binding]; other site
205921003854	active site
205921003855	dimer interface [polypeptide binding]; other site
205921003856	Nuclear pore assembly and biogenesis; Region: Apq12; pfam12716
205921003857	Zinc-dependent metalloprotease, MMP_like subfamily. This group contains matrix metalloproteinases (MMPs), serralysins, and the astacin_like family of proteases; Region: ZnMc_MMP_like; cd04268
205921003858	active site
205921003859	S-formylglutathione hydrolase; Region: PLN02442
205921003860	Predicted esterase [General function prediction only]; Region: COG0627
205921003861	mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595
205921003862	Metallo-beta-lactamase superfamily; Region: Lactamase_B; pfam00753
205921003863	RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521
205921003864	ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: PhnK; COG1101
205921003865	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
205921003866	Walker A/P-loop; other site
205921003867	ATP binding site [chemical binding]; other site
205921003868	Q-loop/lid; other site
205921003869	ABC transporter signature motif; other site
205921003870	Walker B; other site
205921003871	D-loop; other site
205921003872	H-loop/switch region; other site
205921003873	Transmembrane subunit (TM) of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which are involved in the uptake of branched-chain amino acids (AAs), as well as TMs of transporters involved in the uptake of...; Region: TM_PBP1_branched-chain-AA_like; cd06574
205921003874	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
205921003875	TM-ABC transporter signature motif; other site
205921003876	Type I periplasmic ligand-binding domain of uncharacterized ABC-type transport systems that are predicted to be involved in the uptake of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_uncharacterized_transporter; cd06325
205921003877	Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407
205921003878	zinc binding site [ion binding]; other site
205921003879	putative ligand binding site [chemical binding]; other site
205921003880	Fibronectin-binding protein A N-terminus (FbpA); Region: FbpA; pfam05833
205921003881	Domain of unknown function (DUF814); Region: DUF814; pfam05670
205921003882	Alpha-acetolactate decarboxylase; Region: AAL_decarboxy; pfam03306
205921003883	acetolactate synthase; Reviewed; Region: PRK08617
205921003884	Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035
205921003885	PYR/PP interface [polypeptide binding]; other site
205921003886	dimer interface [polypeptide binding]; other site
205921003887	TPP binding site [chemical binding]; other site
205921003888	Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205
205921003889	Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629
205921003890	TPP-binding site [chemical binding]; other site
205921003891	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
205921003892	binding surface
205921003893	TPR motif; other site
205921003894	Anaphase-promoting complex, cyclosome, subunit 3; Region: Apc3; pfam12895
205921003895	Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628
205921003896	Domain of unknown function DUF20; Region: UPF0118; pfam01594
205921003897	Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_29; cd04688
205921003898	nudix motif; other site
205921003899	MutT homolog-1 (MTH1) is a member of the Nudix hydrolase superfamily. MTH1, the mammalian counterpart of MutT, hydrolyzes oxidized purine nucleoside triphosphates, such as 8-oxo-dGTP and 2-hydroxy-ATP, to monophosphates, thereby preventing the...; Region: MTH1; cd03427
205921003900	putative active site [active]
205921003901	nucleotide binding site [chemical binding]; other site
205921003902	nudix motif; other site
205921003903	putative metal binding site [ion binding]; other site
205921003904	Glycosaminoglycan (GAG) polysaccharide lyase family. This family consists of a group of secreted bacterial lyase enzymes capable of acting on glycosaminoglycans, such as hyaluronan and chondroitin, in the extracellular matrix of host tissues; Region: GAG_Lyase; cd01083
205921003905	substrate binding site [chemical binding]; other site
205921003906	catalytic residues [active]
205921003907	dTDP-D-glucose 4,6-dehydratase [Cell envelope biogenesis, outer membrane]; Region: RfbB; COG1088
205921003908	dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246
205921003909	NAD binding site [chemical binding]; other site
205921003910	substrate binding site [chemical binding]; other site
205921003911	homodimer interface [polypeptide binding]; other site
205921003912	active site
205921003913	dTDP-4-dehydrorhamnose 3,5-epimerase and related enzymes [Cell envelope biogenesis, outer membrane]; Region: RfbC; COG1898
205921003914	G1P_TT_short is the short form of glucose-1-phosphate thymidylyltransferase; Region: G1P_TT_short; cd02538
205921003915	glucose-1-phosphate thymidylyltransferase, short form; Region: rmlA; TIGR01207
205921003916	substrate binding site; other site
205921003917	tetramer interface; other site
205921003918	Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665
205921003919	Uncharacterized conserved protein [Function unknown]; Region: COG0327
205921003920	NIF3 (NGG1p interacting factor 3); Region: NIF3; pfam01784
205921003921	Predicted SAM-dependent methyltransferase [General function prediction only]; Region: COG2384
205921003922	Family of unknown function (DUF633); Region: DUF633; pfam04816
205921003923	Putative primosome component and related proteins [DNA replication, recombination, and repair]; Region: DnaD; COG3935
205921003924	Replication initiation and membrane attachment; Region: DnaB_2; pfam07261
205921003925	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
205921003926	active site
205921003927	KxYKxGKxW signal peptide; Region: KxYKxGKxW; TIGR03715
205921003928	Bacterial surface proteins containing Ig-like domains [Cell motility and secretion]; Region: COG5492
205921003929	Bacterial surface proteins containing Ig-like domains [Cell motility and secretion]; Region: COG5492
205921003930	Clostridial hydrophobic W; Region: ChW; pfam07538
205921003931	Clostridial hydrophobic W; Region: ChW; pfam07538
205921003932	Clostridial hydrophobic W; Region: ChW; pfam07538
205921003933	Bacterial surface proteins containing Ig-like domains [Cell motility and secretion]; Region: COG5492
205921003934	Clostridial hydrophobic W; Region: ChW; cl02763
205921003935	Clostridial hydrophobic W; Region: ChW; cl02763
205921003936	Clostridial hydrophobic W; Region: ChW; pfam07538
205921003937	Clostridial hydrophobic W; Region: ChW; pfam07538
205921003938	Clostridial hydrophobic W; Region: ChW; pfam07538
205921003939	Clostridial hydrophobic W; Region: ChW; pfam07538
205921003940	GBS Bsp-like repeat; Region: GBS_Bsp-like; pfam08481
205921003941	A sub-family of peptidase family C39. Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various...; Region: Peptidase_C39A; cd02549
205921003942	putative active site [active]
205921003943	single-stranded-DNA-specific exonuclease RecJ; Region: recJ; TIGR00644
205921003944	DHH family; Region: DHH; pfam01368
205921003945	DHHA1 domain; Region: DHHA1; pfam02272
205921003946	Single-strand DNA-specific exonuclease, C terminal domain; Region: ssDNA-exonuc_C; pfam10141
205921003947	Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300
205921003948	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
205921003949	NAD(P) binding site [chemical binding]; other site
205921003950	active site
205921003951	ribonuclease Z; Region: RNase_Z; TIGR02651
205921003952	Galactose-1-phosphate uridyl transferase, N-terminal domain; Region: GalP_UDP_transf; pfam01087
205921003953	GTP-binding protein HflX; Region: GTP_HflX; TIGR03156
205921003954	GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167
205921003955	HflX GTPase family; Region: HflX; cd01878
205921003956	G1 box; other site
205921003957	GTP/Mg2+ binding site [chemical binding]; other site
205921003958	Switch I region; other site
205921003959	G2 box; other site
205921003960	G3 box; other site
205921003961	Switch II region; other site
205921003962	G4 box; other site
205921003963	G5 box; other site
205921003964	tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091
205921003965	tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324
205921003966	C4-dicarboxylate transporters of the Tellurite-resistance/Dicarboxylate Transporter (TDT) family; Region: TDT_C4-dicarb_trans; cd09325
205921003967	Tellurite resistance protein and related permeases [Inorganic ion transport and metabolism]; Region: TehA; COG1275
205921003968	gating phenylalanine in ion channel; other site
205921003969	YSIRK type signal peptide; Region: YSIRK_signal; pfam04650
205921003970	pullulanase, extracellular, Gram-positive; Region: pullulan_Gpos; TIGR02102
205921003971	Family 41 Carbohydrate-Binding Module from pullulanase-like enzymes; Region: CBM41_pullulanase; cd10315
205921003972	carbohydrate binding site [chemical binding]; other site
205921003973	Family 41 Carbohydrate-Binding Module from pullulanase-like enzymes; Region: CBM41_pullulanase; cd10315
205921003974	carbohydrate binding site [chemical binding]; other site
205921003975	Early set domain associated with the catalytic domain of pullulanase (also called dextrinase and alpha-dextrin endo-1,6-alpha glucosidase); Region: E_set_Pullulanase; cd02860
205921003976	Alpha amylase catalytic domain found in Pullulanase (also called dextrinase; alpha-dextrin endo-1,6-alpha glucosidase), limit dextrinase, and related proteins; Region: AmyAc_Pullulanase_LD-like; cd11341
205921003977	Ca binding site [ion binding]; other site
205921003978	active site
205921003979	catalytic site [active]
205921003980	hypothetical protein; Provisional; Region: PRK07329
205921003981	Polymerase and Histidinol Phosphatase domain; Region: PHP; cl17102
205921003982	active site
205921003983	Uncharacterized subfamily of Uracil-DNA glycosylases; Region: UDG_like_1; cd10033
205921003984	putative uracil binding site [chemical binding]; other site
205921003985	putative active site [active]
205921003986	dipeptidase PepV; Reviewed; Region: PRK07318
205921003987	M20 Peptidase Xaa-His dipeptidase (PepV) degrades hydrophobic dipeptides; Region: M20_PepV; cd03888
205921003988	active site
205921003989	metal binding site [ion binding]; metal-binding site
205921003990	Nitroreductase-like family 1. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_1; cd02137
205921003991	dimer interface [polypeptide binding]; other site
205921003992	FMN binding site [chemical binding]; other site
205921003993	Membrane domain of glycerophosphoryl diester phosphodiesterase; Region: GPDPase_memb; pfam10110
205921003994	Glycerophosphodiester phosphodiesterase domain of uncharacterized bacterial glycerophosphodiester phosphodiesterases; Region: GDPD_memb_like; cd08579
205921003995	Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584
205921003996	putative active site [active]
205921003997	catalytic site [active]
205921003998	putative metal binding site [ion binding]; other site
205921003999	excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558
205921004000	Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434
205921004001	GIY-YIG motif/motif A; other site
205921004002	active site
205921004003	catalytic site [active]
205921004004	putative DNA binding site [nucleotide binding]; other site
205921004005	metal binding site [ion binding]; metal-binding site
205921004006	UvrB/uvrC motif; Region: UVR; pfam02151
205921004007	UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459
205921004008	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1636
205921004009	multidrug efflux protein; Reviewed; Region: PRK01766
205921004010	Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Vibrio cholerae NorM; Region: MATE_NorM_like; cd13131
205921004011	cation binding site [ion binding]; other site
205921004012	Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588
205921004013	dimer interface [polypeptide binding]; other site
205921004014	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
205921004015	Host cell surface-exposed lipoprotein; Region: Lipoprotein_Ltp; pfam07553
205921004016	Host cell surface-exposed lipoprotein; Region: Lipoprotein_Ltp; pfam07553
205921004017	Host cell surface-exposed lipoprotein; Region: Lipoprotein_Ltp; pfam07553
205921004018	Transposase; Region: HTH_Tnp_1; pfam01527
205921004019	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963
205921004020	HTH-like domain; Region: HTH_21; pfam13276
205921004021	Integrase core domain; Region: rve; pfam00665
205921004022	Integrase core domain; Region: rve_3; pfam13683
205921004023	streptococcal histidine triad protein; Region: strep_his_triad; TIGR01363
205921004024	Streptococcal histidine triad protein; Region: Strep_his_triad; pfam04270
205921004025	Streptococcal histidine triad protein; Region: Strep_his_triad; pfam04270
205921004026	ABC-type metal ion transport system, periplasmic component/surface adhesin [Inorganic ion transport and metabolism]; Region: LraI; COG0803
205921004027	Metal binding protein AcdA.  These proteins have been shown to function in the ABC uptake of Zn2+ and Mn2+ and in competence for genetic transformation and adhesion. The AcdA proteins belong to the TroA superfamily of helical backbone metal receptor...; Region: AdcA; cd01017
205921004028	metal binding site [ion binding]; metal-binding site
205921004029	Peptidase S8 family domain in Streptococcal C5a peptidases; Region: Peptidases_S8_C5a_Peptidase; cd07475
205921004030	putative active site [active]
205921004031	catalytic triad [active]
205921004032	PA_C5a_like: Protease-associated domain containing proteins like Streptococcus pyogenes C5a peptidase. This group contains various PA domain-containing proteins similar to S. pyogenes C5a, including, i) Vpr, a minor extracellular serine protease from...; Region: PA_C5a_like; cd02133
205921004033	PA/protease domain interface [polypeptide binding]; other site
205921004034	putative integrin binding motif; other site
205921004035	Peptidase S8 family domain in Streptococcal C5a peptidases; Region: Peptidases_S8_C5a_Peptidase; cd07475
205921004036	Fn3-like domain (DUF1034); Region: DUF1034; pfam06280
205921004037	C-terminal domain of CHU protein family; Region: CHU_C; cl17875
205921004038	Uncharacterized protein family (UPF0236); Region: UPF0236; pfam06782
205921004039	Transposase; Region: HTH_Tnp_1; pfam01527
205921004040	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963
205921004041	HTH-like domain; Region: HTH_21; pfam13276
205921004042	Integrase core domain; Region: rve; pfam00665
205921004043	DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127
205921004044	DNA polymerase III subunit epsilon; Validated; Region: PRK06807
205921004045	active site
205921004046	catalytic site [active]
205921004047	substrate binding site [chemical binding]; other site
205921004048	group I intron endonuclease; Region: grpIintron_endo; TIGR01453
205921004049	Intron encoded nuclease repeat motif; Region: IENR1; smart00497
205921004050	Bacteriophage abortive infection AbiH; Region: AbiH; pfam14253
205921004051	phiLC3 phage and phage-related integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes various bacterial (mainly gram positive) and phage integrases, including those similar to Lactococcus...; Region: INT_phiLC3_C; cd01189
205921004052	Int/Topo IB signature motif; other site
205921004053	Plasmid replication protein; Region: Rep_2; pfam01719
205921004054	Separase, a protease involved in sister chromatid separation [Cell division and chromosome partitioning / Posttranslational modification, protein turnover, chaperones]; Region: ESP1; COG5155
205921004055	Eco57I restriction-modification methylase; Region: Eco57I; pfam07669
205921004056	TaqI-like C-terminal specificity domain; Region: TaqI_C; pfam12950
205921004057	Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387
205921004058	core dimer interface [polypeptide binding]; other site
205921004059	L10 interface [polypeptide binding]; other site
205921004060	L11 interface [polypeptide binding]; other site
205921004061	putative EF-Tu interaction site [polypeptide binding]; other site
205921004062	putative EF-G interaction site [polypeptide binding]; other site
205921004063	Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797
205921004064	23S rRNA interface [nucleotide binding]; other site
205921004065	Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site
205921004066	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
205921004067	ATPases associated with a variety of cellular activities; Region: AAA; smart00382
205921004068	Walker A motif; other site
205921004069	ATP binding site [chemical binding]; other site
205921004070	Walker B motif; other site
205921004071	arginine finger; other site
205921004072	UvrB/uvrC motif; Region: UVR; pfam02151
205921004073	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
205921004074	Walker A motif; other site
205921004075	ATP binding site [chemical binding]; other site
205921004076	Walker B motif; other site
205921004077	arginine finger; other site
205921004078	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086
205921004079	homocysteine methyltransferase; Provisional; Region: mmuM; PRK09485
205921004080	Homocysteine S-methyltransferase; Region: S-methyl_trans; pfam02574
205921004081	S-methylmethionine transporter; Provisional; Region: PRK11387
205921004082	Protein of unknown function with HXXEE motif; Region: HXXEE; pfam13787
205921004083	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
205921004084	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
205921004085	YihA (EngB) GTPase family; Region: YihA_EngB; cd01876
205921004086	G1 box; other site
205921004087	GTP/Mg2+ binding site [chemical binding]; other site
205921004088	Switch I region; other site
205921004089	G2 box; other site
205921004090	G3 box; other site
205921004091	Switch II region; other site
205921004092	G4 box; other site
205921004093	G5 box; other site
205921004094	ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342
205921004095	ClpX C4-type zinc finger; Region: zf-C4_ClpX; pfam06689
205921004096	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
205921004097	Walker A motif; other site
205921004098	ATP binding site [chemical binding]; other site
205921004099	Walker B motif; other site
205921004100	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086
205921004101	Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262
205921004102	Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cd00209
205921004103	folate binding site [chemical binding]; other site
205921004104	NADP+ binding site [chemical binding]; other site
205921004105	thymidylate synthase; Reviewed; Region: thyA; PRK01827
205921004106	Thymidylate synthase and pyrimidine hydroxymethylase: Thymidylate synthase (TS) and deoxycytidylate hydroxymethylase (dCMP-HMase) are homologs that catalyze analogous alkylation of C5 of pyrimidine nucleotides. Both enzymes are involved in the...; Region: TS_Pyrimidine_HMase; cd00351
205921004107	dimerization interface [polypeptide binding]; other site
205921004108	active site
205921004109	"initiating" condensing enzymes are a subclass of decarboxylating condensing enzymes, including beta-ketoacyl [ACP] synthase, type III and polyketide synthases, type III, which include chalcone synthase and related enzymes. They are...; Region: init_cond_enzymes; cd00827
205921004110	3-hydroxy-3-methylglutaryl CoA synthase, prokaryotic clade; Region: HMG-CoA-S_prok; TIGR01835
205921004111	dimer interface [polypeptide binding]; other site
205921004112	active site
205921004113	Class II hydroxymethylglutaryl-coenzyme A (HMG-CoA) reductase (HMGR); Region: HMG-CoA_reductase_classII; cd00644
205921004114	homodimer interface [polypeptide binding]; other site
205921004115	catalytic residues [active]
205921004116	NAD binding site [chemical binding]; other site
205921004117	substrate binding pocket [chemical binding]; other site
205921004118	flexible flap; other site
205921004119	Domain of unknown function (DUF1836); Region: DUF1836; pfam08876
205921004120	Predicted membrane protein, hemolysin III homolog [General function prediction only]; Region: COG1272
205921004121	channel protein, hemolysin III family; Region: hlyIII; TIGR01065
205921004122	Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase [Lipid metabolism / General function prediction only]; Region: LCB5; COG1597
205921004123	Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781
205921004124	Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388
205921004125	C-terminal, alpha helical domain of Class Omega-like Glutathione S-transferases; Region: GST_C_Omega_like; cd03190
205921004126	putative substrate binding pocket (H-site) [chemical binding]; other site
205921004127	N-terminal domain interface [polypeptide binding]; other site
205921004128	isopentenyl pyrophosphate isomerase; Provisional; Region: PRK05437
205921004129	Isopentenyl-diphosphate:dimethylallyl diphosphate isomerase type 2 (IDI-2) FMN-binding domain. Two types of IDIs have been characterized at present. The long known IDI-1 is only dependent on divalent metals for activity, whereas IDI-2 requires a metal; Region: IDI-2_FMN; cd02811
205921004130	homotetramer interface [polypeptide binding]; other site
205921004131	FMN binding site [chemical binding]; other site
205921004132	homodimer contacts [polypeptide binding]; other site
205921004133	putative active site [active]
205921004134	putative substrate binding site [chemical binding]; other site
205921004135	Mevalonate kinase [Lipid metabolism]; Region: ERG12; COG1577
205921004136	GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288
205921004137	GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544
205921004138	diphosphomevalonate decarboxylase; Region: mevDPdecarb; TIGR01240
205921004139	diphosphomevalonate decarboxylase; Region: PLN02407
205921004140	Mevalonate kinase [Lipid metabolism]; Region: ERG12; COG1577
205921004141	GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544
205921004142	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
205921004143	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
205921004144	dimer interface [polypeptide binding]; other site
205921004145	phosphorylation site [posttranslational modification]
205921004146	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
205921004147	ATP binding site [chemical binding]; other site
205921004148	Mg2+ binding site [ion binding]; other site
205921004149	G-X-G motif; other site
205921004150	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
205921004151	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
205921004152	active site
205921004153	phosphorylation site [posttranslational modification]
205921004154	intermolecular recognition site; other site
205921004155	dimerization interface [polypeptide binding]; other site
205921004156	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
205921004157	DNA binding site [nucleotide binding]
205921004158	Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399
205921004159	synthetase active site [active]
205921004160	NTP binding site [chemical binding]; other site
205921004161	metal binding site [ion binding]; metal-binding site
205921004162	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
205921004163	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
205921004164	ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254
205921004165	Walker A/P-loop; other site
205921004166	ATP binding site [chemical binding]; other site
205921004167	Q-loop/lid; other site
205921004168	ABC transporter signature motif; other site
205921004169	Walker B; other site
205921004170	D-loop; other site
205921004171	H-loop/switch region; other site
205921004172	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
205921004173	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
205921004174	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
205921004175	Walker A/P-loop; other site
205921004176	ATP binding site [chemical binding]; other site
205921004177	Q-loop/lid; other site
205921004178	ABC transporter signature motif; other site
205921004179	Walker B; other site
205921004180	D-loop; other site
205921004181	H-loop/switch region; other site
205921004182	Transcriptional regulators [Transcription]; Region: MarR; COG1846
205921004183	MarR family; Region: MarR_2; pfam12802
205921004184	5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737
205921004185	Bacillus subtilis YhcR endonuclease and related proteins, N-terminal metallophosphatase domain; Region: MPP_YhcR_N; cd07412
205921004186	putative active site [active]
205921004187	putative metal binding site [ion binding]; other site
205921004188	5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872
205921004189	Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487
205921004190	active site
205921004191	catalytic residues [active]
205921004192	metal binding site [ion binding]; metal-binding site
205921004193	glutamate dehydrogenase; Provisional; Region: PRK09414
205921004194	Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812
205921004195	NAD(P) binding domain of glutamate dehydrogenase, subgroup 2; Region: NAD_bind_2_Glu_DH; cd05313
205921004196	NAD(P) binding site [chemical binding]; other site
205921004197	Short repeat of unknown function (DUF308); Region: DUF308; cl15828
205921004198	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
205921004199	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
205921004200	ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254
205921004201	Walker A/P-loop; other site
205921004202	ATP binding site [chemical binding]; other site
205921004203	Q-loop/lid; other site
205921004204	ABC transporter signature motif; other site
205921004205	Walker B; other site
205921004206	D-loop; other site
205921004207	H-loop/switch region; other site
205921004208	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
205921004209	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
205921004210	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
205921004211	Walker A/P-loop; other site
205921004212	ATP binding site [chemical binding]; other site
205921004213	Q-loop/lid; other site
205921004214	ABC transporter signature motif; other site
205921004215	Walker B; other site
205921004216	D-loop; other site
205921004217	H-loop/switch region; other site
205921004218	Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673
205921004219	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
205921004220	Coenzyme A binding pocket [chemical binding]; other site
205921004221	ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488
205921004222	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
205921004223	Walker A/P-loop; other site
205921004224	ATP binding site [chemical binding]; other site
205921004225	Q-loop/lid; other site
205921004226	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
205921004227	ABC transporter; Region: ABC_tran_2; pfam12848
205921004228	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
205921004229	tRNA CCA-pyrophosphorylase; Provisional; Region: PRK13299
205921004230	Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398
205921004231	active site
205921004232	NTP binding site [chemical binding]; other site
205921004233	metal binding triad [ion binding]; metal-binding site
205921004234	Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627
205921004235	tRNA nucleotidyltransferase domain 2 putative; Region: tRNA_NucTran2_2; pfam13735
205921004236	EDD domain protein, DegV family; Region: DegV; TIGR00762
205921004237	Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645
205921004238	Protein of unknown function (DUF1149); Region: DUF1149; pfam06619
205921004239	Predicted membrane protein (DUF2127); Region: DUF2127; cl01785
205921004240	PTS system 2-O-a-mannosyl-D-glycerate specific transporter subunit IIABC; Provisional; Region: PRK09765
205921004241	PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211
205921004242	active site
205921004243	phosphorylation site [posttranslational modification]
205921004244	PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569
205921004245	active site
205921004246	P-loop; other site
205921004247	phosphorylation site [posttranslational modification]
205921004248	Phosphotransferase system, fructose-specific IIC component [Carbohydrate transport and metabolism]; Region: FruA; COG1299
205921004249	Fructose-1-phosphate kinase and related fructose-6-phosphate kinase (PfkB) [Carbohydrate transport and metabolism]; Region: FruK; COG1105
205921004250	1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164
205921004251	putative substrate binding site [chemical binding]; other site
205921004252	putative ATP binding site [chemical binding]; other site
205921004253	Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349
205921004254	helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420
205921004255	DeoR C terminal sensor domain; Region: DeoRC; pfam00455
205921004256	FemAB family; Region: FemAB; pfam02388
205921004257	Gram-positive signal peptide, YSIRK family; Region: YSIRK_signal; TIGR01168
205921004258	Bacterial SH3 domain; Region: SH3_5; pfam08460
205921004259	Bacterial SH3 domain; Region: SH3_5; pfam08460
205921004260	GBS Bsp-like repeat; Region: GBS_Bsp-like; pfam08481
205921004261	Bacterial SH3 domain; Region: SH3_5; pfam08460
205921004262	Bacterial SH3 domain; Region: SH3_5; pfam08460
205921004263	2-dehydropantoate 2-reductase; Reviewed; Region: PRK06522
205921004264	Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558
205921004265	Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546
205921004266	Predicted membrane protein, putative toxin regulator [General function prediction only]; Region: PfoR; COG3641
205921004267	Phosphotransferase system, EIIC; Region: PTS_EIIC_2; pfam13303
205921004268	Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492
205921004269	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
205921004270	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
205921004271	tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026
205921004272	16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK00122
205921004273	RimM N-terminal domain; Region: RimM; pfam01782
205921004274	M protein trans-acting positive regulator (MGA) HTH domain; Region: HTH_Mga; pfam08280
205921004275	Mga helix-turn-helix domain; Region: Mga; pfam05043
205921004276	M protein trans-acting positive regulator (MGA) PRD domain; Region: PRD_Mga; pfam08270
205921004277	Predicted RNA-binding protein (contains KH domain) [General function prediction only]; Region: COG1837
205921004278	KH domain; Region: KH_4; pfam13083
205921004279	G-X-X-G motif; other site
205921004280	30S ribosomal protein S16; Reviewed; Region: rpsP; PRK00040
205921004281	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
205921004282	ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577
205921004283	FtsX-like permease family; Region: FtsX; pfam02687
205921004284	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
205921004285	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
205921004286	Walker A/P-loop; other site
205921004287	ATP binding site [chemical binding]; other site
205921004288	Q-loop/lid; other site
205921004289	ABC transporter signature motif; other site
205921004290	Walker B; other site
205921004291	D-loop; other site
205921004292	H-loop/switch region; other site
205921004293	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
205921004294	HlyD family secretion protein; Region: HlyD_3; pfam13437
205921004295	ATP-grasp domain; Region: ATP-grasp_4; cl17255
205921004296	Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787
205921004297	carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12838
205921004298	Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; pfam00988
205921004299	Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744
205921004300	catalytic site [active]
205921004301	subunit interface [polypeptide binding]; other site
205921004302	Pyrimidine operon attenuation protein/uracil phosphoribosyltransferase [Nucleotide transport and metabolism]; Region: PyrR; COG2065
205921004303	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
205921004304	active site
205921004305	Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564
205921004306	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
205921004307	RNA binding surface [nucleotide binding]; other site
205921004308	Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869
205921004309	active site
205921004310	lipoprotein signal peptidase; Provisional; Region: PRK14797
205921004311	Transcriptional regulator [Transcription]; Region: LysR; COG0583
205921004312	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
205921004313	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
205921004314	dimerization interface [polypeptide binding]; other site
205921004315	50S ribosomal protein L27; Validated; Region: rpmA; PRK05435
205921004316	Protein of unknown function (DUF464); Region: DUF464; pfam04327
205921004317	50S ribosomal protein L21; Validated; Region: rplU; PRK05573
205921004318	Bacterial capsule synthesis protein PGA_cap; Region: PGA_cap; smart00854
205921004319	CapA and related proteins, metallophosphatase domain; Region: MPP_CapA; cd07381
205921004320	putative active site [active]
205921004321	putative metal binding site [ion binding]; other site
205921004322	thiamine biosynthesis protein ThiI; Provisional; Region: PRK01565
205921004323	THUMP domain of thiamine biosynthesis protein ThiI; Region: THUMP_ThiI; cd11716
205921004324	ThiI is required for thiazole synthesis in the thiamine biosynthesis pathway. It belongs to the Adenosine Nucleotide Hydrolysis suoerfamily and predicted to bind to Adenosine nucleotide; Region: ThiI; cd01712
205921004325	Ligand Binding Site [chemical binding]; other site
205921004326	Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104
205921004327	cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402
205921004328	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
205921004329	catalytic residue [active]
205921004330	glutathione reductase; Validated; Region: PRK06116
205921004331	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
205921004332	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
205921004333	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
205921004334	hypothetical protein; Provisional; Region: PRK13676
205921004335	Chorismate synthase [Amino acid transport and metabolism]; Region: AroC; COG0082
205921004336	Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304
205921004337	Tetramer interface [polypeptide binding]; other site
205921004338	active site
205921004339	FMN-binding site [chemical binding]; other site
205921004340	Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195
205921004341	active site
205921004342	dimer interface [polypeptide binding]; other site
205921004343	metal binding site [ion binding]; metal-binding site
205921004344	3-dehydroquinate dehydratase [Amino acid transport and metabolism]; Region: AroD; COG0710
205921004345	Type I 3-dehydroquinase, (3-dehydroquinate dehydratase or DHQase); Region: DHQase_I; cd00502
205921004346	active site
205921004347	catalytic residue [active]
205921004348	dimer interface [polypeptide binding]; other site
205921004349	Predicted SAM-dependent methyltransferases [General function prediction only]; Region: COG1092
205921004350	Middle domain of the SAM-dependent methyltransferase RlmI and related proteins; Region: RlmI_M_like; cd11572
205921004351	putative RNA binding site [nucleotide binding]; other site
205921004352	Methyltransferase domain; Region: Methyltransf_26; pfam13659
205921004353	Phosphoglycerol transferase and related proteins, alkaline phosphatase superfamily [Cell envelope biogenesis, outer membrane]; Region: MdoB; COG1368
205921004354	Sulfatase; Region: Sulfatase; pfam00884
205921004355	Ribosomal protein L20; Region: Ribosomal_L20; cd07026
205921004356	23S rRNA binding site [nucleotide binding]; other site
205921004357	L21 binding site [polypeptide binding]; other site
205921004358	L13 binding site [polypeptide binding]; other site
205921004359	50S ribosomal protein L35; Reviewed; Region: rpmI; PRK00172
205921004360	translation initiation factor IF-3; Reviewed; Region: infC; PRK00028
205921004361	Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198
205921004362	Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707
205921004363	cytidylate kinase; Provisional; Region: cmk; PRK00023
205921004364	Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020
205921004365	CMP-binding site; other site
205921004366	The sites determining sugar specificity; other site
205921004367	Ferredoxin [Energy production and conversion]; Region: Fer; COG1141
205921004368	peptidase T; Region: peptidase-T; TIGR01882
205921004369	M20 Peptidase T specifically cleaves tripeptides; Region: M20_peptT; cd03892
205921004370	metal binding site [ion binding]; metal-binding site
205921004371	dimer interface [polypeptide binding]; other site
205921004372	Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244
205921004373	Stage V sporulation protein B, also known as Stage III sporulation protein F, and related proteins; Region: MATE_SpoVB_like; cd13124
205921004374	UDP-N-acetylmuramoylalanyl-D-glutamate--L-lysine ligase; Provisional; Region: PRK14022
205921004375	Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225
205921004376	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
205921004377	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
205921004378	ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120
205921004379	ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214
205921004380	Walker A/P-loop; other site
205921004381	ATP binding site [chemical binding]; other site
205921004382	Q-loop/lid; other site
205921004383	ABC transporter signature motif; other site
205921004384	Walker B; other site
205921004385	D-loop; other site
205921004386	H-loop/switch region; other site
205921004387	ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614
205921004388	Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+.  Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262
205921004389	intersubunit interface [polypeptide binding]; other site
205921004390	iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577
205921004391	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
205921004392	ABC-ATPase subunit  interface; other site
205921004393	dimer interface [polypeptide binding]; other site
205921004394	putative PBP binding regions; other site
205921004395	iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577
205921004396	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
205921004397	ABC-ATPase subunit  interface; other site
205921004398	dimer interface [polypeptide binding]; other site
205921004399	putative PBP binding regions; other site
205921004400	Domain of unknown function (DUF1803); Region: DUF1803; pfam08820
205921004401	Domain of unknown function (DUF1803); Region: DUF1803; pfam08820
205921004402	putative manganese-dependent inorganic pyrophosphatase; Provisional; Region: PRK05427
205921004403	DHH family; Region: DHH; pfam01368
205921004404	DHHA2 domain; Region: DHHA2; pfam02833
205921004405	pyruvate formate-lyase 1-activating enzyme; Region: PFLA; TIGR02493
205921004406	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
205921004407	FeS/SAM binding site; other site
205921004408	Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253
205921004409	Domain of unknown function DUF21; Region: DUF21; pfam01595
205921004410	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590
205921004411	Transporter associated domain; Region: CorC_HlyC; smart01091
205921004412	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
205921004413	S-adenosylmethionine binding site [chemical binding]; other site
205921004414	Predicted Fe-S oxidoreductase [General function prediction only]; Region: COG1242
205921004415	PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392
205921004416	Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671
205921004417	active site
205921004418	Predicted membrane protein [Function unknown]; Region: COG3601
205921004419	Protein of unknown function (DUF3816); Region: DUF3816; pfam12822
205921004420	Sortases are cysteine transpeptidases, found in gram-positive bacteria, that anchor surface proteins to peptidoglycans of the bacterial cell wall envelope. They do so by catalyzing a transpeptidation reaction in which the surface protein substrate is...; Region: Sortase; cd00004
205921004421	active site
205921004422	catalytic site [active]
205921004423	Sortase C (SrtC) or subfamily-3 sortases are membrane cysteine transpeptidases found in Gram-positive bacteria that anchor surface proteins to peptidoglycans of the bacterial cell wall envelope. This involves a transpeptidation reaction in which the...; Region: Sortase_C_3; cd05827
205921004424	active site
205921004425	catalytic site [active]
205921004426	fimbrial isopeptide formation D2 domain; Region: RrgB_K2N_iso_D2; TIGR04226
205921004427	Listeria-Bacteroides repeat domain (List_Bact_rpt); Region: Flg_new; pfam09479
205921004428	Listeria/Bacterioides repeat; Region: List_Bact_rpt; TIGR02543
205921004429	Cna protein B-type domain; Region: Cna_B; pfam05738
205921004430	LPXTG-motif cell wall anchor domain; Region: LPXTG_anchor; TIGR01167
205921004431	signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227
205921004432	The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530
205921004433	Catalytic site [active]
205921004434	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
205921004435	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
205921004436	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
205921004437	L-rhamnosyltransferase; Region: rhamnosyltran; TIGR01556
205921004438	active site
205921004439	Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244
205921004440	Polysaccharide biosynthesis protein; Region: Polysacc_synt; pfam01943
205921004441	Predicted membrane protein (DUF2142); Region: DUF2142; pfam09913
205921004442	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
205921004443	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
205921004444	active site
205921004445	Predicted glycosyltransferases [General function prediction only]; Region: COG1216
205921004446	Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_d; cd04196
205921004447	Probable Catalytic site; other site
205921004448	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
205921004449	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
205921004450	NAD(P) binding site [chemical binding]; other site
205921004451	active site
205921004452	CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516
205921004453	substrate binding site; other site
205921004454	dimer interface; other site
205921004455	LicD family; Region: LicD; cl01378
205921004456	Uncharacterized conserved protein (DUF2304); Region: DUF2304; cl01034
205921004457	DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179
205921004458	Ligand binding site; other site
205921004459	Putative Catalytic site; other site
205921004460	DXD motif; other site
205921004461	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
205921004462	Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_d; cd04196
205921004463	Probable Catalytic site; other site
205921004464	This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_6; cd04955
205921004465	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
205921004466	dTDP-6-deoxy-L-lyxo-4-hexulose reductase and related proteins, extended (e) SDRs; Region: dTDP_HR_like_SDR_e; cd05254
205921004467	RmlD substrate binding domain; Region: RmlD_sub_bind; pfam04321
205921004468	NADP binding site [chemical binding]; other site
205921004469	active site
205921004470	putative substrate binding site [chemical binding]; other site
205921004471	Predicted metal-sulfur cluster biosynthetic enzyme [General function prediction only]; Region: PaaD; COG2151
205921004472	RNA polymerase sigma factor RpoD; Validated; Region: PRK09210
205921004473	Sigma-70 factor, region 1.1; Region: Sigma70_r1_1; pfam03979
205921004474	Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140
205921004475	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
205921004476	Sigma-70 region 3; Region: Sigma70_r3; pfam04539
205921004477	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
205921004478	DNA binding residues [nucleotide binding]
205921004479	DNA primase; Validated; Region: dnaG; PRK05667
205921004480	CHC2 zinc finger; Region: zf-CHC2; pfam01807
205921004481	DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275
205921004482	TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364
205921004483	active site
205921004484	metal binding site [ion binding]; metal-binding site
205921004485	interdomain interaction site; other site
205921004486	DnaB-helicase binding domain of primase; Region: DnaB_bind; pfam10410
205921004487	Large-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscL; COG1970
205921004488	large-conductance mechanosensitive channel; Reviewed; Region: mscL; PRK00567
205921004489	30S ribosomal protein S21; Reviewed; Region: rpsU; PRK00270
205921004490	Flagellin N-methylase; Region: FliB; pfam03692
205921004491	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
205921004492	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
205921004493	substrate binding pocket [chemical binding]; other site
205921004494	membrane-bound complex binding site; other site
205921004495	hinge residues; other site
205921004496	Ammonium Transporter Family; Region: Ammonium_transp; cl03012
205921004497	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738
205921004498	putative rhodanese-related sulfurtransferase; Provisional; Region: PRK00142
205921004499	Member of the Rhodanese Homology Domain superfamily. This CD includes Escherichia coli YceA, Bacillus subtilis YbfQ, and similar uncharacterized proteins; Region: RHOD_YceA; cd01518
205921004500	active site residue [active]
205921004501	Protein of unknown function (DUF3650); Region: DUF3650; pfam12368
205921004502	Sugar phosphate permease [Carbohydrate transport and metabolism]; Region: UhpC; COG2271
205921004503	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
205921004504	putative substrate translocation pore; other site
205921004505	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
205921004506	glycogen/starch/alpha-glucan phosphorylases; Region: P_ylase; TIGR02093
205921004507	4-alpha-glucanotransferase; Provisional; Region: PRK14508
205921004508	Transcriptional regulators [Transcription]; Region: PurR; COG1609
205921004509	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
205921004510	DNA binding site [nucleotide binding]
205921004511	domain linker motif; other site
205921004512	Ligand-binding domain of uncharacterized transcription regulator ycjW which is a member of the LacI-GalR family repressors; Region: PBP1_ycjW_transcription_regulator_like; cd06294
205921004513	putative dimerization interface [polypeptide binding]; other site
205921004514	putative ligand binding site [chemical binding]; other site
205921004515	Maltose-binding periplasmic proteins/domains [Carbohydrate transport and metabolism]; Region: MalE; COG2182
205921004516	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
205921004517	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
205921004518	dimer interface [polypeptide binding]; other site
205921004519	conserved gate region; other site
205921004520	putative PBP binding loops; other site
205921004521	ABC-ATPase subunit interface; other site
205921004522	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
205921004523	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
205921004524	dimer interface [polypeptide binding]; other site
205921004525	conserved gate region; other site
205921004526	putative PBP binding loops; other site
205921004527	ABC-ATPase subunit interface; other site
205921004528	amino acid/peptide transporter (Peptide:H+ symporter), bacterial; Region: yjdL_sub1_fam; TIGR00924
205921004529	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
205921004530	putative substrate translocation pore; other site
205921004531	POT family; Region: PTR2; cl17359
205921004532	MutT homolog-1 (MTH1) is a member of the Nudix hydrolase superfamily. MTH1, the mammalian counterpart of MutT, hydrolyzes oxidized purine nucleoside triphosphates, such as 8-oxo-dGTP and 2-hydroxy-ATP, to monophosphates, thereby preventing the...; Region: MTH1; cd03427
205921004533	putative active site [active]
205921004534	nucleotide binding site [chemical binding]; other site
205921004535	nudix motif; other site
205921004536	putative metal binding site [ion binding]; other site
205921004537	accessory Sec system glycosyltransferase GtfB; Region: TIGR02919
205921004538	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
205921004539	accessory Sec system glycosylation protein GtfA; Region: TIGR02918
205921004540	This family is most closely related to the GT1 family of glycosyltransferases and is named after gtfA in Streptococcus gordonii, where it plays a role in the O-linked glycosylation of GspB, a cell surface glycoprotein involved in platelet binding.  In...; Region: GT1_gtfA_like; cd04949
205921004541	accessory Sec system translocase SecA2; Region: secA2; TIGR03714
205921004542	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
205921004543	ATP binding site [chemical binding]; other site
205921004544	putative Mg++ binding site [ion binding]; other site
205921004545	SecA preprotein cross-linking domain; Region: SecA_PP_bind; pfam01043
205921004546	accessory Sec system protein Asp3; Region: acc_sec_asp3; TIGR03711
205921004547	accessory Sec system protein Asp2; Region: acc_sec_asp2; TIGR03712
205921004548	accessory Sec system protein Asp1; Region: acc_sec_asp1; TIGR03713
205921004549	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
205921004550	preprotein translocase subunit SecY; Reviewed; Region: secY; PRK12417
205921004551	SecY translocase; Region: SecY; pfam00344
205921004552	glycosyltransferase, SP_1767 family; Region: glyco_access_1; TIGR03728
205921004553	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
205921004554	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761
205921004555	active site
205921004556	Glycosyl transferase family 8; Region: Glyco_transf_8; pfam01501
205921004557	A4GalT_like proteins catalyze the addition of galactose or glucose residues to the lipooligosaccharide (LOS) or lipopolysaccharide (LPS) of the bacterial cell surface; Region: GT8_A4GalT_like; cd04194
205921004558	Ligand binding site; other site
205921004559	metal-binding site
205921004560	A4GalT_like proteins catalyze the addition of galactose or glucose residues to the lipooligosaccharide (LOS) or lipopolysaccharide (LPS) of the bacterial cell surface; Region: GT8_A4GalT_like; cd04194
205921004561	Glycosyl transferase family 8; Region: Glyco_transf_8; pfam01501
205921004562	Ligand binding site; other site
205921004563	metal-binding site
205921004564	A4GalT_like proteins catalyze the addition of galactose or glucose residues to the lipooligosaccharide (LOS) or lipopolysaccharide (LPS) of the bacterial cell surface; Region: GT8_A4GalT_like; cd04194
205921004565	Glycosyl transferase family 8; Region: Glyco_transf_8; pfam01501
205921004566	Ligand binding site; other site
205921004567	metal-binding site
205921004568	beta-1,6-galactofuranosyltransferase; Provisional; Region: PRK09814
205921004569	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
205921004570	KxYKxGKxW signal peptide; Region: KxYKxGKxW; TIGR03715
205921004571	serine-rich repeat adhesion glycoprotein AST domain; Region: ser_adhes_Nterm; TIGR04224
205921004572	C-terminus of bacterial fibrinogen-binding adhesin; Region: SdrG_C_C; pfam10425
205921004573	excinuclease ABC subunit B; Provisional; Region: PRK05298
205921004574	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
205921004575	ATP binding site [chemical binding]; other site
205921004576	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
205921004577	nucleotide binding region [chemical binding]; other site
205921004578	ATP-binding site [chemical binding]; other site
205921004579	Ultra-violet resistance protein B; Region: UvrB; pfam12344
205921004580	CAAX protease self-immunity; Region: Abi; pfam02517
205921004581	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
205921004582	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
205921004583	substrate binding pocket [chemical binding]; other site
205921004584	membrane-bound complex binding site; other site
205921004585	hinge residues; other site
205921004586	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
205921004587	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
205921004588	substrate binding pocket [chemical binding]; other site
205921004589	membrane-bound complex binding site; other site
205921004590	hinge residues; other site
205921004591	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
205921004592	dimer interface [polypeptide binding]; other site
205921004593	conserved gate region; other site
205921004594	putative PBP binding loops; other site
205921004595	ABC-ATPase subunit interface; other site
205921004596	ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126
205921004597	ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262
205921004598	Walker A/P-loop; other site
205921004599	ATP binding site [chemical binding]; other site
205921004600	Q-loop/lid; other site
205921004601	ABC transporter signature motif; other site
205921004602	Walker B; other site
205921004603	D-loop; other site
205921004604	H-loop/switch region; other site
205921004605	GTPase CgtA; Reviewed; Region: obgE; PRK12297
205921004606	GTP1/OBG; Region: GTP1_OBG; pfam01018
205921004607	Obg GTPase; Region: Obg; cd01898
205921004608	G1 box; other site
205921004609	GTP/Mg2+ binding site [chemical binding]; other site
205921004610	Switch I region; other site
205921004611	G2 box; other site
205921004612	G3 box; other site
205921004613	Switch II region; other site
205921004614	G4 box; other site
205921004615	G5 box; other site
205921004616	Domain of unknown function (DUF1967); Region: DUF1967; pfam09269
205921004617	Protein of unknown function (DUF4044); Region: DUF4044; pfam13253
205921004618	Thermophilic metalloprotease (M29); Region: Peptidase_M29; pfam02073
205921004619	Leucyl aminopeptidase (aminopeptidase T) [Amino acid transport and metabolism]; Region: AmpS; COG2309
205921004620	amidase; Provisional; Region: PRK06529
205921004621	Amidase; Region: Amidase; cl11426
205921004622	16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187
205921004623	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
205921004624	RNA binding surface [nucleotide binding]; other site
205921004625	Pseudouridine synthase, Escherichia coli RsuA like; Region: PseudoU_synth_RsuA; cd02553
205921004626	active site
205921004627	uracil binding [chemical binding]; other site
205921004628	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
205921004629	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
205921004630	active site
205921004631	catalytic tetrad [active]
205921004632	NAD(P)H:FMN oxidoreductase family. This domain catalyzes the reduction of flavin, nitrocompound, quinones and azo compounds using NADH or NADPH as an electron donor. The enzyme is a homodimer, and each monomer binds a FMN as co-factor. This family...; Region: NfsB_like_nitroreductase; cd02149
205921004633	dimer interface [polypeptide binding]; other site
205921004634	FMN binding site [chemical binding]; other site
205921004635	Glyoxalase I catalyzes the isomerization of the hemithioacetal, formed by a 2-oxoaldehyde and glutathione, to S-D-lactoylglutathione; Region: Glyoxalase_I; cd07233
205921004636	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
205921004637	dimer interface [polypeptide binding]; other site
205921004638	active site
205921004639	metal binding site [ion binding]; metal-binding site
205921004640	glutathione binding site [chemical binding]; other site
205921004641	undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714
205921004642	Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187
205921004643	Ligand binding site; other site
205921004644	Putative Catalytic site; other site
205921004645	DXD motif; other site
205921004646	Amino acid permease; Region: AA_permease_2; pfam13520
205921004647	Spore germination protein; Region: Spore_permease; cl17796
205921004648	Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294
205921004649	SmpB-tmRNA interface; other site
205921004650	ribonuclease R; Region: RNase_R; TIGR02063
205921004651	Ribonuclease B OB domain; Region: OB_RNB; pfam08206
205921004652	RNB domain; Region: RNB; pfam00773
205921004653	S1_RNase_R: RNase R C-terminal S1 domain. RNase R is a processive 3' to 5' exoribonuclease, which is a homolog of RNase II. RNase R degrades RNA with secondary structure having a 3' overhang of at least 7 nucleotides. RNase R and PNPase...; Region: S1_RNase_R; cd04471
205921004654	RNA binding site [nucleotide binding]; other site
205921004655	preprotein translocase subunit SecG; Reviewed; Region: secG; PRK06870
205921004656	similar to ribosomoal protein L33 type 1; identified by match to protein family HMM PF00471; match to protein family HMM TIGR01023
205921004657	drug efflux system protein MdtG; Provisional; Region: PRK09874
205921004658	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
205921004659	putative substrate translocation pore; other site
205921004660	ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555
205921004661	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
205921004662	Walker A/P-loop; other site
205921004663	ATP binding site [chemical binding]; other site
205921004664	Q-loop/lid; other site
205921004665	ABC transporter signature motif; other site
205921004666	Walker B; other site
205921004667	D-loop; other site
205921004668	H-loop/switch region; other site
205921004669	Dephospho-CoA kinase [Coenzyme metabolism]; Region: CoaE; COG0237
205921004670	Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022
205921004671	CoA-binding site [chemical binding]; other site
205921004672	ATP-binding [chemical binding]; other site
205921004673	formamidopyrimidine/5-formyluracil/ 5-hydroxymethyluracil DNA glycosylase; Validated; Region: PRK01103
205921004674	N-terminal domain of Escherichia coli Fpg1/MutM and related bacterial DNA glycosylases; Region: EcFpg-like_N; cd08966
205921004675	DNA binding site [nucleotide binding]
205921004676	catalytic residue [active]
205921004677	H2TH interface [polypeptide binding]; other site
205921004678	putative catalytic residues [active]
205921004679	turnover-facilitating residue; other site
205921004680	intercalation triad [nucleotide binding]; other site
205921004681	8OG recognition residue [nucleotide binding]; other site
205921004682	putative reading head residues; other site
205921004683	Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831
205921004684	Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827
205921004685	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
205921004686	sequence-specific DNA binding site [nucleotide binding]; other site
205921004687	salt bridge; other site
205921004688	transcriptional activator, Rgg/GadR/MutR family, C-terminal domain; Region: RGG_Cterm; TIGR01716
205921004689	Transglutaminase/protease-like homologues; Region: TGc; smart00460
205921004690	CAAX protease self-immunity; Region: Abi; pfam02517
205921004691	GTPase Era; Reviewed; Region: era; PRK00089
205921004692	E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163
205921004693	G1 box; other site
205921004694	GTP/Mg2+ binding site [chemical binding]; other site
205921004695	Switch I region; other site
205921004696	G2 box; other site
205921004697	Switch II region; other site
205921004698	G3 box; other site
205921004699	G4 box; other site
205921004700	G5 box; other site
205921004701	KH domain; Region: KH_2; pfam07650
205921004702	Diacylglycerol kinase [Cell envelope biogenesis, outer membrane]; Region: DgkA; COG0818
205921004703	metal-binding heat shock protein; Provisional; Region: PRK00016
205921004704	O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315
205921004705	Leucine carboxyl methyltransferase; Region: LCM; pfam04072
205921004706	Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447
205921004707	nudix motif; other site
205921004708	Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702
205921004709	PhoH-like protein; Region: PhoH; pfam02562
205921004710	myosin-cross-reactive antigen; Provisional; Region: PRK13977
205921004711	hypothetical protein; Provisional; Region: PRK13672
205921004712	methionine sulfoxide reductase A; Provisional; Region: PRK14054
205921004713	Predicted RNA-bindining protein (contains S1 and HTH domains) [General function prediction only]; Region: COG2996
205921004714	S1 domain; Region: S1_2; pfam13509
205921004715	Ribosomal protein S1-like RNA-binding domain; Region: S1; smart00316
205921004716	ribosome recycling factor; Reviewed; Region: frr; PRK00083
205921004717	Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation.  Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520
205921004718	hinge region; other site
205921004719	UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254
205921004720	putative nucleotide binding site [chemical binding]; other site
205921004721	uridine monophosphate binding site [chemical binding]; other site
205921004722	homohexameric interface [polypeptide binding]; other site
205921004723	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
205921004724	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
205921004725	Walker A/P-loop; other site
205921004726	ATP binding site [chemical binding]; other site
205921004727	Q-loop/lid; other site
205921004728	ABC transporter signature motif; other site
205921004729	Walker B; other site
205921004730	D-loop; other site
205921004731	H-loop/switch region; other site
205921004732	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
205921004733	nickel import ATP-binding protein NikD; Region: nickel_nikD; TIGR02770
205921004734	Walker A/P-loop; other site
205921004735	ATP binding site [chemical binding]; other site
205921004736	Q-loop/lid; other site
205921004737	ABC transporter signature motif; other site
205921004738	Walker B; other site
205921004739	D-loop; other site
205921004740	H-loop/switch region; other site
205921004741	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
205921004742	nickel ABC transporter, permease subunit NikC; Region: nickel_nikC; TIGR02790
205921004743	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
205921004744	dimer interface [polypeptide binding]; other site
205921004745	conserved gate region; other site
205921004746	putative PBP binding loops; other site
205921004747	ABC-ATPase subunit interface; other site
205921004748	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601
205921004749	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
205921004750	dimer interface [polypeptide binding]; other site
205921004751	conserved gate region; other site
205921004752	putative PBP binding loops; other site
205921004753	ABC-ATPase subunit interface; other site
205921004754	ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747
205921004755	The substrate-binding component of an ABC-type nickel import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA; cd08489
205921004756	substrate binding site [chemical binding]; other site
205921004757	Ribosomal protein L1.  The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA.  In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403
205921004758	mRNA/rRNA interface [nucleotide binding]; other site
205921004759	50S ribosomal protein L11; Validated; Region: rplK; PRK00140
205921004760	Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349
205921004761	23S rRNA interface [nucleotide binding]; other site
205921004762	L7/L12 interface [polypeptide binding]; other site
205921004763	putative thiostrepton binding site; other site
205921004764	L25 interface [polypeptide binding]; other site
205921004765	Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826
205921004766	Helix-turn-helix domain; Region: HTH_38; pfam13936
205921004767	Integrase core domain; Region: rve; pfam00665
205921004768	Major Facilitator Superfamily; Region: MFS_1; pfam07690
205921004769	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
205921004770	putative substrate translocation pore; other site
205921004771	Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473
205921004772	M20 Peptidase Aminoacylase 1 family; Region: M20_Acy1; cd03886
205921004773	metal binding site [ion binding]; metal-binding site
205921004774	dimer interface [polypeptide binding]; other site
205921004775	Transcriptional regulator [Transcription]; Region: LysR; COG0583
205921004776	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
205921004777	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
205921004778	dimerization interface [polypeptide binding]; other site
205921004779	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963
205921004780	putative transposase OrfB; Reviewed; Region: PHA02517
205921004781	HTH-like domain; Region: HTH_21; pfam13276
205921004782	Integrase core domain; Region: rve; pfam00665
205921004783	Integrase core domain; Region: rve_2; pfam13333
205921004784	aminodeoxychorismate synthase; Provisional; Region: PRK07508
205921004785	chorismate binding enzyme; Region: Chorismate_bind; cl10555
205921004786	substrate-cofactor binding pocket; other site
205921004787	Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115
205921004788	Aminotransferase class IV; Region: Aminotran_4; pfam01063
205921004789	pyridoxal 5'-phosphate binding site [chemical binding]; other site
205921004790	DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674
205921004791	FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580
205921004792	Ftsk gamma domain; Region: Ftsk_gamma; pfam09397
205921004793	Peptidyl-prolyl cis-trans isomerase (rotamase) - cyclophilin family [Posttranslational modification, protein turnover, chaperones]; Region: PpiB; COG0652
205921004794	active site
205921004795	ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108
205921004796	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
205921004797	ABC-ATPase subunit  interface; other site
205921004798	dimer interface [polypeptide binding]; other site
205921004799	putative PBP binding regions; other site
205921004800	ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121
205921004801	ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235
205921004802	ABC-type metal ion transport system, periplasmic component/surface adhesin [Inorganic ion transport and metabolism]; Region: LraI; COG0803
205921004803	Metal binding protein PsaA.  These proteins have been shown to function as initial receptors in ABC transport of Mn2+ and as surface adhesins in some eubacterial species.  They belong to the TroA superfamily of periplasmic metal binding proteins that...; Region: PsaA; cd01137
205921004804	metal binding site [ion binding]; metal-binding site
205921004805	Mn-dependent transcriptional regulator [Transcription]; Region: TroR; COG1321
205921004806	Iron dependent repressor, N-terminal DNA binding domain; Region: Fe_dep_repress; pfam01325
205921004807	Iron dependent repressor, metal binding and dimerisation domain; Region: Fe_dep_repr_C; pfam02742
205921004808	FeoA domain; Region: FeoA; pfam04023
205921004809	5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Validated; Region: PRK05584
205921004810	5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Region: MTA/SAH-Nsdase; TIGR01704
205921004811	ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424
205921004812	dimer interface [polypeptide binding]; other site
205921004813	ADP-ribose binding site [chemical binding]; other site
205921004814	active site
205921004815	nudix motif; other site
205921004816	metal binding site [ion binding]; metal-binding site
205921004817	bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase; Provisional; Region: glmU; PRK14354
205921004818	N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540
205921004819	Substrate binding site; other site
205921004820	Mg++ binding site; other site
205921004821	N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353
205921004822	active site
205921004823	substrate binding site [chemical binding]; other site
205921004824	CoA binding site [chemical binding]; other site
205921004825	Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588
205921004826	dimer interface [polypeptide binding]; other site
205921004827	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
205921004828	This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_16; cd07263
205921004829	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
205921004830	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
205921004831	3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK06550
205921004832	classical (c) SDRs; Region: SDR_c; cd05233
205921004833	NAD(P) binding site [chemical binding]; other site
205921004834	active site
205921004835	Protein of unknown function (DUF2829); Region: DUF2829; pfam11195
205921004836	YbaK-like.  The YbaK family of deacylase domains includes the INS amino acid-editing domain of  the bacterial class II prolyl tRNA synthetase (ProRS), and it's trans-acting homologs, YbaK, ProX, and PrdX. The primary function of INS is to hydrolyze...; Region: YbaK_like; cl00022
205921004837	Acetyltransferases [General function prediction only]; Region: RimI; COG0456
205921004838	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
205921004839	Coenzyme A binding pocket [chemical binding]; other site
205921004840	poly-beta-1,6 N-acetyl-D-glucosamine synthase; Region: PgaC_IcaA; TIGR03937
205921004841	CESA_like is  the cellulose synthase superfamily; Region: CESA_like; cd06423
205921004842	DXD motif; other site
205921004843	CotH protein; Region: CotH; pfam08757
205921004844	Uncharacterized membrane protein [Function unknown]; Region: SapB; COG1285
205921004845	Polyphosphate(polyP) polymerase domain of yeast vacuolar transport chaperone (VTC) proteins VTC-2, -3 and- 4, and similar proteins; Region: PolyPPase_VTC_like; cd07750
205921004846	putative metal binding residues [ion binding]; other site
205921004847	signature motif; other site
205921004848	dimer interface [polypeptide binding]; other site
205921004849	active site
205921004850	polyP binding site; other site
205921004851	substrate binding site [chemical binding]; other site
205921004852	acceptor-phosphate pocket; other site
205921004853	Branched-chain amino acid transport protein; Region: Branch_AA_trans; cl00547
205921004854	methionyl-tRNA synthetase; Reviewed; Region: PRK12267
205921004855	catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814
205921004856	active site
205921004857	HIGH motif; other site
205921004858	KMSKS motif; other site
205921004859	Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957
205921004860	tRNA binding surface [nucleotide binding]; other site
205921004861	anticodon binding site; other site
205921004862	tRNA-binding-domain-containing Escherichia coli methionyl-tRNA synthetase (EcMetRS)-like proteins.  This family includes EcMetRS and Aquifex aeolicus Trbp111 (AaTrbp111). This domain has general tRNA binding properties.  MetRS aminoacylates methionine...; Region: tRNA_bind_EcMetRS_like; cd02800
205921004863	dimer interface [polypeptide binding]; other site
205921004864	putative tRNA-binding site [nucleotide binding]; other site
205921004865	tellurite resistance protein TehB; Provisional; Region: PRK12335
205921004866	Domain of unknown function (DUF1971); Region: DUF1971; pfam09313
205921004867	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
205921004868	S-adenosylmethionine binding site [chemical binding]; other site
205921004869	Protein of unknown function (DUF1275); Region: DUF1275; pfam06912
205921004870	Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455
205921004871	Alpha/beta hydrolase of unknown function (DUF915); Region: DUF915; pfam06028
205921004872	Human Ape1-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: Ape1-like_AP-endo; cd09087
205921004873	active site
205921004874	putative catalytic site [active]
205921004875	DNA binding site [nucleotide binding]
205921004876	putative phosphate binding site [ion binding]; other site
205921004877	metal binding site A [ion binding]; metal-binding site
205921004878	AP binding site [nucleotide binding]; other site
205921004879	metal binding site B [ion binding]; metal-binding site
205921004880	Arsenate Reductase (ArsC) family, unknown subfamily; uncharacterized proteins containing a CXXC motif with similarity to thioredoxin (TRX)-fold arsenic reductases, ArsC. Proteins containing a redox active CXXC motif like TRX and glutaredoxin (GRX)...; Region: ArsC_like; cd03036
205921004881	ArsC family; Region: ArsC; pfam03960
205921004882	putative ArsC-like catalytic residues; other site
205921004883	putative TRX-like catalytic residues [active]
205921004884	Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350
205921004885	The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445
205921004886	DNA binding site [nucleotide binding]
205921004887	active site
205921004888	Putative D-3-Phosphoglycerate Dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_like_3; cd12174
205921004889	putative ligand binding site [chemical binding]; other site
205921004890	Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111
205921004891	putative NAD binding site [chemical binding]; other site
205921004892	putative catalytic site [active]
205921004893	C-terminal ACT (regulatory) domain of D-3-Phosphoglycerate Dehydrogenase (3PGDH) found in fungi and bacteria; Region: ACT_3PGDH; cd04901
205921004894	L-serine binding site [chemical binding]; other site
205921004895	ACT domain interface; other site
205921004896	Uncharacterized protein involved in copper resistance [Inorganic ion transport and metabolism]; Region: CutC; COG3142
205921004897	Predicted methyltransferases [General function prediction only]; Region: COG0313
205921004898	Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648
205921004899	putative SAM binding site [chemical binding]; other site
205921004900	putative homodimer interface [polypeptide binding]; other site
205921004901	DNA replication intiation control protein YabA; Reviewed; Region: PRK13169
205921004902	DNA polymerase III subunit delta'; Validated; Region: PRK07276
205921004903	DNA polymerase III subunit delta'; Validated; Region: PRK08485
205921004904	thymidylate kinase; Validated; Region: tmk; PRK00698
205921004905	Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672
205921004906	TMP-binding site; other site
205921004907	ATP-binding site [chemical binding]; other site
205921004908	Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826
205921004909	Helix-turn-helix domain; Region: HTH_38; pfam13936
205921004910	Integrase core domain; Region: rve; pfam00665
205921004911	FOG: CBS domain [General function prediction only]; Region: COG0517
205921004912	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in  the acetoin utilization proteins in bacteria. Acetoin is a product of fermentative metabolism in many prokaryotic and eukaryotic microorganisms.  They produce...; Region: CBS_pair_ACT_assoc2; cd04585
205921004913	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410
205921004914	ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224
205921004915	Walker A/P-loop; other site
205921004916	ATP binding site [chemical binding]; other site
205921004917	Q-loop/lid; other site
205921004918	ABC transporter signature motif; other site
205921004919	Walker B; other site
205921004920	D-loop; other site
205921004921	H-loop/switch region; other site
205921004922	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411
205921004923	ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219
205921004924	Walker A/P-loop; other site
205921004925	ATP binding site [chemical binding]; other site
205921004926	Q-loop/lid; other site
205921004927	ABC transporter signature motif; other site
205921004928	Walker B; other site
205921004929	D-loop; other site
205921004930	H-loop/switch region; other site
205921004931	ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177
205921004932	Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581
205921004933	TM-ABC transporter signature motif; other site
205921004934	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
205921004935	Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582
205921004936	TM-ABC transporter signature motif; other site
205921004937	hypothetical protein; Provisional; Region: PRK02302
205921004938	Clp protease; Region: CLP_protease; pfam00574
205921004939	Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017
205921004940	oligomer interface [polypeptide binding]; other site
205921004941	active site residues [active]
205921004942	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
205921004943	active site
205921004944	Bifunctional PLP-dependent enzyme with beta-cystathionase and maltose regulon repressor activities [Amino acid transport and metabolism]; Region: MalY; COG1168
205921004945	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
205921004946	pyridoxal 5'-phosphate binding site [chemical binding]; other site
205921004947	homodimer interface [polypeptide binding]; other site
205921004948	catalytic residue [active]
205921004949	Predicted rRNA methylase (SpoU class) [Translation, ribosomal structure and biogenesis]; Region: CspR; COG0219
205921004950	Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531
205921004951	potassium transporter peripheral membrane component; Reviewed; Region: trkA; PRK09496
205921004952	TrkA-N domain; Region: TrkA_N; pfam02254
205921004953	TrkA-C domain; Region: TrkA_C; pfam02080
205921004954	TrkA-N domain; Region: TrkA_N; pfam02254
205921004955	TrkA-C domain; Region: TrkA_C; pfam02080
205921004956	Trk-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: TrkG; COG0168
205921004957	potassium uptake protein, TrkH family; Region: 2a38; TIGR00933
205921004958	hypothetical protein; Validated; Region: PRK00041
205921004959	16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187
205921004960	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
205921004961	RNA binding surface [nucleotide binding]; other site
205921004962	Pseudouridine synthases, RsuA subfamily; Region: PseudoU_synth_RsuA_like; cd02870
205921004963	active site
205921004964	segregation and condensation protein B; Reviewed; Region: scpB; PRK00135
205921004965	segregation and condensation protein A; Reviewed; Region: scpA; PRK00104
205921004966	site-specific tyrosine recombinase XerD-like protein; Reviewed; Region: xerD; PRK02436
205921004967	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
205921004968	DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182
205921004969	DNA binding site [nucleotide binding]
205921004970	Int/Topo IB signature motif; other site
205921004971	active site
205921004972	catalytic residues [active]
205921004973	FOG: CBS domain [General function prediction only]; Region: COG0517
205921004974	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_30; cd04643
205921004975	Escherichia coli YfcE and related proteins, metallophosphatase domain; Region: MPP_YfcE; cd00841
205921004976	active site
205921004977	metal binding site [ion binding]; metal-binding site
205921004978	homotetramer interface [polypeptide binding]; other site
205921004979	putative deoxyribonucleotide triphosphate pyrophosphatase/unknown domain fusion protein; Reviewed; Region: PRK02491
205921004980	NTPase/HAM1.  This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515
205921004981	active site
205921004982	dimerization interface [polypeptide binding]; other site
205921004983	glutamate racemase; Provisional; Region: PRK00865
205921004984	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3763
205921004985	Predicted small molecule binding protein (contains 3H domain) [General function prediction only]; Region: COG1827
205921004986	HTH domain; Region: HTH_11; pfam08279
205921004987	3H domain; Region: 3H; pfam02829
205921004988	Integral membrane protein, interacts with FtsH [General function prediction only]; Region: COG0670
205921004989	Bacterial BAX inhibitor (BI)-1/YccA-like proteins; Region: BI-1-like_bacterial; cd10432
205921004990	Predicted HD superfamily hydrolase [General function prediction only]; Region: COG1418
205921004991	Protein Kinases, catalytic domain; Region: PKc_like; cl09925
205921004992	substrate binding site [chemical binding]; other site
205921004993	activation loop (A-loop); other site
205921004994	rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566
205921004995	RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; smart00967
205921004996	SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588
205921004997	acylphosphatase; Provisional; Region: PRK14434
205921004998	OxaA-like protein precursor; Provisional; Region: PRK02463
205921004999	membrane protein insertase, YidC/Oxa1 family, C-terminal domain; Region: yidC_oxa1_cterm; TIGR03592
205921005000	ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215
205921005001	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
205921005002	dimer interface [polypeptide binding]; other site
205921005003	conserved gate region; other site
205921005004	putative PBP binding loops; other site
205921005005	ABC-ATPase subunit interface; other site
205921005006	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
205921005007	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
205921005008	substrate binding pocket [chemical binding]; other site
205921005009	membrane-bound complex binding site; other site
205921005010	hinge residues; other site
205921005011	amidase; Provisional; Region: PRK06529
205921005012	Amidase; Region: Amidase; cl11426
205921005013	transcription elongation factor GreA; Reviewed; Region: greA; PRK00226
205921005014	Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449
205921005015	Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272
205921005016	Aminodeoxychorismate lyase [Coenzyme transport and metabolism]; Region: COG1559
205921005017	proteins similar to Escherichia coli yceG; Region: yceG_like; cd08010
205921005018	dimerization interface [polypeptide binding]; other site
205921005019	Acetyltransferases [General function prediction only]; Region: RimI; COG0456
205921005020	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
205921005021	Coenzyme A binding pocket [chemical binding]; other site
205921005022	UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421
205921005023	Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225
205921005024	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
205921005025	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
205921005026	SWIM zinc finger; Region: SWIM; pfam04434
205921005027	Bacterial SNF2 helicase associated; Region: SNF2_assoc; pfam08455
205921005028	SNF2 family N-terminal domain; Region: SNF2_N; pfam00176
205921005029	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
205921005030	ATP binding site [chemical binding]; other site
205921005031	putative Mg++ binding site [ion binding]; other site
205921005032	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
205921005033	nucleotide binding region [chemical binding]; other site
205921005034	ATP-binding site [chemical binding]; other site
205921005035	GTP-binding protein Der; Reviewed; Region: PRK00093
205921005036	EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894
205921005037	G1 box; other site
205921005038	GTP/Mg2+ binding site [chemical binding]; other site
205921005039	Switch I region; other site
205921005040	G2 box; other site
205921005041	Switch II region; other site
205921005042	G3 box; other site
205921005043	G4 box; other site
205921005044	G5 box; other site
205921005045	EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895
205921005046	G1 box; other site
205921005047	GTP/Mg2+ binding site [chemical binding]; other site
205921005048	Switch I region; other site
205921005049	G2 box; other site
205921005050	G3 box; other site
205921005051	Switch II region; other site
205921005052	G4 box; other site
205921005053	G5 box; other site
205921005054	primosomal protein DnaI; Reviewed; Region: PRK08939
205921005055	Primosomal protein DnaI N-terminus; Region: DnaI_N; pfam07319
205921005056	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
205921005057	Walker A motif; other site
205921005058	ATP binding site [chemical binding]; other site
205921005059	Walker B motif; other site
205921005060	Replication initiation/membrane attachment protein [DNA replication, recombination, and repair]; Region: DnaB; COG3611
205921005061	Replication initiation and membrane attachment; Region: DnaB_2; cl12121
205921005062	transcriptional regulator NrdR; Validated; Region: nrdR; PRK00464
205921005063	Transcription factor S-II (TFIIS); Region: TFIIS_C; cl02609
205921005064	ATP cone domain; Region: ATP-cone; pfam03477
205921005065	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
205921005066	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
205921005067	dimerization interface [polypeptide binding]; other site
205921005068	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
205921005069	dimer interface [polypeptide binding]; other site
205921005070	phosphorylation site [posttranslational modification]
205921005071	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
205921005072	ATP binding site [chemical binding]; other site
205921005073	Mg2+ binding site [ion binding]; other site
205921005074	G-X-G motif; other site
205921005075	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
205921005076	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
205921005077	active site
205921005078	phosphorylation site [posttranslational modification]
205921005079	intermolecular recognition site; other site
205921005080	dimerization interface [polypeptide binding]; other site
205921005081	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
205921005082	DNA binding site [nucleotide binding]
205921005083	Uncharacterized ACR, COG1399; Region: DUF177; cl00616
205921005084	heat shock protein HtpX; Provisional; Region: PRK04897
205921005085	Uncharacterized conserved protein [Function unknown]; Region: LemA; COG1704
205921005086	Predicted S-adenosylmethionine-dependent methyltransferase involved in bacterial cell division [Cell envelope biogenesis, outer membrane]; Region: GidB; COG0357
205921005087	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
205921005088	S-adenosylmethionine binding site [chemical binding]; other site
205921005089	potassium uptake protein, TrkH family; Region: 2a38; TIGR00933
205921005090	Trk-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: TrkG; COG0168
205921005091	K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569
205921005092	TrkA-N domain; Region: TrkA_N; pfam02254
205921005093	TrkA-C domain; Region: TrkA_C; pfam02080
205921005094	ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619
205921005095	ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122
205921005096	First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225
205921005097	Walker A/P-loop; other site
205921005098	ATP binding site [chemical binding]; other site
205921005099	Q-loop/lid; other site
205921005100	ABC transporter signature motif; other site
205921005101	Walker B; other site
205921005102	D-loop; other site
205921005103	H-loop/switch region; other site
205921005104	ATP-binding cassette cobalt transporter; Region: DUF3744; pfam12558
205921005105	ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122
205921005106	First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225
205921005107	Walker A/P-loop; other site
205921005108	ATP binding site [chemical binding]; other site
205921005109	Q-loop/lid; other site
205921005110	ABC transporter signature motif; other site
205921005111	Walker B; other site
205921005112	D-loop; other site
205921005113	H-loop/switch region; other site
205921005114	hypothetical protein; Provisional; Region: PRK13661
205921005115	serine/threonine transporter SstT; Provisional; Region: PRK13628
205921005116	Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301
205921005117	formaldehyde dehydrogenase (FDH)-like; Region: FDH_like_ADH2; cd08286
205921005118	Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063
205921005119	catalytic Zn binding site [ion binding]; other site
205921005120	structural Zn binding site [ion binding]; other site
205921005121	NAD(P) binding site [chemical binding]; other site
205921005122	ABC-type metal ion transport system, permease component [Inorganic ion transport and metabolism]; Region: AbcD; COG2011
205921005123	ABC-type metal ion transport system, ATPase component [Inorganic ion transport and metabolism]; Region: AbcC; COG1135
205921005124	ATP-binding cassette domain of methionine transporter; Region: ABC_MetN_methionine_transporter; cd03258
205921005125	Walker A/P-loop; other site
205921005126	ATP binding site [chemical binding]; other site
205921005127	Q-loop/lid; other site
205921005128	ABC transporter signature motif; other site
205921005129	Walker B; other site
205921005130	D-loop; other site
205921005131	H-loop/switch region; other site
205921005132	NIL domain; Region: NIL; pfam09383
205921005133	hypothetical protein; Provisional; Region: PRK06446
205921005134	Uncharacterized M20 Dipeptidases; Region: M20_dipept_like_4; cd05681
205921005135	metal binding site [ion binding]; metal-binding site
205921005136	dimer interface [polypeptide binding]; other site
205921005137	NLPA lipoprotein; Region: Lipoprotein_9; pfam03180
205921005138	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
205921005139	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
205921005140	substrate binding pocket [chemical binding]; other site
205921005141	membrane-bound complex binding site; other site
205921005142	hinge residues; other site
205921005143	Peptidase C26; Region: Peptidase_C26; pfam07722
205921005144	Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_2; cd01745
205921005145	catalytic triad [active]
205921005146	hypothetical protein; Provisional; Region: PRK12378
205921005147	dihydroxyacetone kinase subunit DhaK; Provisional; Region: PRK14481; cl10557
205921005148	Dihydroxyacetone kinase [Carbohydrate transport and metabolism]; Region: DAK1; COG2376
205921005149	probable dihydroxyacetone kinase regulator; Region: DHAK_reg; TIGR02366
205921005150	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
205921005151	dihydroxyacetone kinase subunit DhaK; Provisional; Region: PRK14481
205921005152	Dihydroxyacetone kinase [Carbohydrate transport and metabolism]; Region: DAK1; COG2376
205921005153	dihydroxyacetone kinase, phosphoprotein-dependent, L subunit; Region: dha_L_ycgS; TIGR02365
205921005154	phosphotransferase mannnose-specific family component IIA; Provisional; Region: PRK14484
205921005155	Glycerol uptake facilitator and related permeases (Major Intrinsic Protein Family) [Carbohydrate transport and metabolism]; Region: GlpF; COG0580
205921005156	amphipathic channel; other site
205921005157	Asn-Pro-Ala signature motifs; other site
205921005158	Mannose-6-phosphate isomerase [Carbohydrate transport and metabolism]; Region: {ManC}; COG0662
205921005159	Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789
205921005160	Helix-Turn-Helix DNA binding domain of the transcription regulators TipAL, Mta, and SkgA; Region: HTH_TipAL-Mta; cd01106
205921005161	DNA binding residues [nucleotide binding]
205921005162	dimer interface [polypeptide binding]; other site
205921005163	TipAS antibiotic-recognition domain; Region: TipAS; pfam07739
205921005164	hypothetical protein; Provisional; Region: PRK13670
205921005165	HIGH Nucleotidyl Transferase; Region: HIGH_NTase1; pfam05636
205921005166	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
205921005167	S-adenosylmethionine binding site [chemical binding]; other site
205921005168	Uncharacterized homolog of plant Iojap protein [Function unknown]; Region: COG0799
205921005169	Nicotinamidase_ related amidohydrolases.  Cysteine hydrolases of unknown function that share the catalytic triad with other amidohydrolases, like nicotinamidase, which converts nicotinamide to nicotinic acid and ammonia; Region: nicotinamidase_related; cd01014
205921005170	catalytic triad [active]
205921005171	conserved cis-peptide bond; other site
205921005172	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
205921005173	Zn2+ binding site [ion binding]; other site
205921005174	Mg2+ binding site [ion binding]; other site
205921005175	nicotinic acid mononucleotide adenylyltransferase; Provisional; Region: nadD; PRK00071
205921005176	Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165
205921005177	active site
205921005178	(T/H)XGH motif; other site
205921005179	Predicted RNA-binding protein containing KH domain, possibly ribosomal protein [Translation, ribosomal structure and biogenesis]; Region: COG1534
205921005180	GTPase YqeH; Provisional; Region: PRK13796
205921005181	Circularly permuted YqeH GTPase; Region: YqeH; cd01855
205921005182	GTP/Mg2+ binding site [chemical binding]; other site
205921005183	G4 box; other site
205921005184	G5 box; other site
205921005185	G1 box; other site
205921005186	Switch I region; other site
205921005187	G2 box; other site
205921005188	G3 box; other site
205921005189	Switch II region; other site
205921005190	Predicted hydrolase of the HAD superfamily [General function prediction only]; Region: COG2179
205921005191	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
205921005192	active site
205921005193	motif I; other site
205921005194	motif II; other site
205921005195	EamA-like transporter family; Region: EamA; pfam00892
205921005196	Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950
205921005197	EamA-like transporter family; Region: EamA; pfam00892
205921005198	aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477
205921005199	GatB/GatE catalytic domain; Region: GatB_N; pfam02934
205921005200	GatB domain; Region: GatB_Yqey; pfam02637
205921005201	Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154
205921005202	aspartyl/glutamyl-tRNA amidotransferase subunit A; Reviewed; Region: gatA; PRK00012
205921005203	aspartyl/glutamyl-tRNA amidotransferase subunit C; Reviewed; Region: gatC; PRK00034
205921005204	pyruvate phosphate dikinase; Provisional; Region: PRK09279
205921005205	Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326
205921005206	Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326
205921005207	PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391
205921005208	PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896
205921005209	PEP synthetase regulatory protein; Provisional; Region: PRK05339
205921005210	FOG: CBS domain [General function prediction only]; Region: COG0517
205921005211	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_4; cd04617
205921005212	3-hydroxybutyryl-CoA dehydrogenase; Validated; Region: PRK08293
205921005213	3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737
205921005214	3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725
205921005215	Isochorismatase family; Region: Isochorismatase; pfam00857
205921005216	Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431
205921005217	catalytic triad [active]
205921005218	conserved cis-peptide bond; other site
205921005219	transcriptional repressor CodY; Validated; Region: PRK04158
205921005220	CodY GAF-like domain; Region: CodY; pfam06018
205921005221	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
205921005222	dimerization interface [polypeptide binding]; other site
205921005223	putative Zn2+ binding site [ion binding]; other site
205921005224	putative DNA binding site [nucleotide binding]; other site
205921005225	aminotransferase AlaT; Validated; Region: PRK09265
205921005226	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
205921005227	pyridoxal 5'-phosphate binding site [chemical binding]; other site
205921005228	homodimer interface [polypeptide binding]; other site
205921005229	catalytic residue [active]
205921005230	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
205921005231	Ligand Binding Site [chemical binding]; other site
205921005232	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
205921005233	haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282
205921005234	active site
205921005235	motif I; other site
205921005236	motif II; other site
205921005237	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
205921005238	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4696
205921005239	metal binding site [ion binding]; metal-binding site
205921005240	Type II (periplasmic) bacterial L-asparaginase; Region: L-asparaginase_II; cd08964
205921005241	active site
205921005242	homotetramer interface [polypeptide binding]; other site
205921005243	homodimer interface [polypeptide binding]; other site
205921005244	Shikimate 5-dehydrogenase [Amino acid transport and metabolism]; Region: AroE; COG0169
205921005245	Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501
205921005246	NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065
205921005247	shikimate binding site; other site
205921005248	NAD(P) binding site [chemical binding]; other site
205921005249	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
205921005250	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
205921005251	active site
205921005252	catalytic tetrad [active]
205921005253	ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917
205921005254	RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488
205921005255	generic binding surface II; other site
205921005256	ssDNA binding site; other site
205921005257	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
205921005258	ATP binding site [chemical binding]; other site
205921005259	putative Mg++ binding site [ion binding]; other site
205921005260	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
205921005261	nucleotide binding region [chemical binding]; other site
205921005262	ATP-binding site [chemical binding]; other site
205921005263	Surface antigen [General function prediction only]; Region: COG3942
205921005264	CHAP domain; Region: CHAP; pfam05257
205921005265	alanine racemase; Reviewed; Region: alr; PRK00053
205921005266	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430
205921005267	active site
205921005268	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
205921005269	dimer interface [polypeptide binding]; other site
205921005270	substrate binding site [chemical binding]; other site
205921005271	catalytic residues [active]
205921005272	4'-phosphopantetheinyl transferase; Provisional; Region: acpS; PRK00070
205921005273	phospho-2-dehydro-3-deoxyheptonate aldolase; Validated; Region: PRK09261
205921005274	DAHP synthetase I family; Region: DAHP_synth_1; pfam00793
205921005275	preprotein translocase subunit SecA; Reviewed; Region: PRK12904
205921005276	SecA preprotein cross-linking domain; Region: SecA_PP_bind; pfam01043
205921005277	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
205921005278	nucleotide binding region [chemical binding]; other site
205921005279	ATP-binding site [chemical binding]; other site
205921005280	SEC-C motif; Region: SEC-C; pfam02810
205921005281	Phosphomannose isomerase [Carbohydrate transport and metabolism]; Region: ManA; COG1482
205921005282	mannose-6-phosphate isomerase, class I; Region: manA; TIGR00218
205921005283	Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940
205921005284	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012
205921005285	nucleotide binding site [chemical binding]; other site
205921005286	PTS system, sucrose-specific IIBC component; Region: PTS-II-BC-sucr; TIGR01996
205921005287	PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212
205921005288	active site turn [active]
205921005289	phosphorylation site [posttranslational modification]
205921005290	Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263
205921005291	PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_glc; cd00210
205921005292	HPr interaction site; other site
205921005293	glycerol kinase (GK) interaction site [polypeptide binding]; other site
205921005294	active site
205921005295	phosphorylation site [posttranslational modification]
205921005296	sucrose-6-phosphate hydrolase; Region: scrB_fam; TIGR01322
205921005297	Glycosyl hydrolase family 32, beta-fructosidases; Region: GH32_B_Fructosidase; cd08996
205921005298	substrate binding [chemical binding]; other site
205921005299	active site
205921005300	Glycosyl hydrolases family 32 C terminal; Region: Glyco_hydro_32C; pfam08244
205921005301	Transcriptional regulators [Transcription]; Region: PurR; COG1609
205921005302	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
205921005303	DNA binding site [nucleotide binding]
205921005304	domain linker motif; other site
205921005305	Ligand binding domain of the lacI-like transcription regulator from a novel metal-reducing bacterium Alkaliphilus Metalliredigens (strain Qymf) and its close homologs; Region: PBP1_Qymf_like; cd06291
205921005306	dimerization interface [polypeptide binding]; other site
205921005307	ligand binding site [chemical binding]; other site
205921005308	sodium binding site [ion binding]; other site
205921005309	transcription antitermination protein NusB; Reviewed; Region: nusB; PRK00202
205921005310	putative RNA binding site [nucleotide binding]; other site
205921005311	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1302
205921005312	elongation factor P; Validated; Region: PRK00529
205921005313	Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207
205921005314	S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470
205921005315	RNA binding site [nucleotide binding]; other site
205921005316	S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794
205921005317	RNA binding site [nucleotide binding]; other site
205921005318	Domain of unknown function (DUF4176); Region: DUF4176; pfam13780
205921005319	Deoxycytidylate deaminase domain. Deoxycytidylate deaminase catalyzes the deamination of dCMP to dUMP, providing the nucleotide substrate for thymidylate synthase. The enzyme binds Zn++, which is required for catalytic activity. The activity of the...; Region: deoxycytidylate_deaminase; cd01286
205921005320	catalytic motif [active]
205921005321	Zn binding site [ion binding]; other site
205921005322	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
205921005323	Major Facilitator Superfamily; Region: MFS_1; pfam07690
205921005324	putative substrate translocation pore; other site
205921005325	excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349
205921005326	ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270
205921005327	ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270
205921005328	ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271
205921005329	Protein of unknown function (DUF1129); Region: DUF1129; cl11555
205921005330	Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598
205921005331	uncharacterized bacterial subfamily of the Escherichia coli CorA-Salmonella typhimurium ZntB family; Region: EcCorA_ZntB-like_u2; cd12827
205921005332	Cl binding site [ion binding]; other site
205921005333	oligomer interface [polypeptide binding]; other site
205921005334	30S ribosomal protein S18; Reviewed; Region: rpsR; PRK00391
205921005335	Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629
205921005336	SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496
205921005337	dimer interface [polypeptide binding]; other site
205921005338	ssDNA binding site [nucleotide binding]; other site
205921005339	tetramer (dimer of dimers) interface [polypeptide binding]; other site
205921005340	30S ribosomal protein S6; Reviewed; Region: rpsF; PRK00453
205921005341	A/G-specific DNA glycosylase [DNA replication, recombination, and repair]; Region: MutY; COG1194
205921005342	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056
205921005343	minor groove reading motif; other site
205921005344	helix-hairpin-helix signature motif; other site
205921005345	substrate binding pocket [chemical binding]; other site
205921005346	active site
205921005347	DNA glycosylase (MutY in bacteria and hMYH in humans) is responsible for repairing misread  A*oxoG residues to C*G by removing the inappropriately paired adenine base from the DNA backbone. It belongs to the Nudix hydrolase superfamily and is important...; Region: DNA_Glycosylase_C; cd03431
205921005348	DNA binding and oxoG recognition site [nucleotide binding]
205921005349	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
205921005350	non-specific DNA binding site [nucleotide binding]; other site
205921005351	salt bridge; other site
205921005352	sequence-specific DNA binding site [nucleotide binding]; other site
205921005353	TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947
205921005354	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
205921005355	catalytic residues [active]
205921005356	similar to PAP2 family protein; identified by match to protein family HMM PF01569
205921005357	Mismatch repair ATPase (MutS family) [DNA replication, recombination, and repair]; Region: COG1193
205921005358	MutS domain III; Region: MutS_III; pfam05192
205921005359	ATP-binding cassette domain of MutS2; Region: ABC_MutS2; cd03280
205921005360	Walker A/P-loop; other site
205921005361	ATP binding site [chemical binding]; other site
205921005362	Q-loop/lid; other site
205921005363	ABC transporter signature motif; other site
205921005364	Walker B; other site
205921005365	D-loop; other site
205921005366	H-loop/switch region; other site
205921005367	Smr domain; Region: Smr; pfam01713
205921005368	Uncharacterized membrane protein, required for colicin V production [General function prediction only]; Region: CvpA; COG1286
205921005369	Colicin V production protein; Region: Colicin_V; pfam02674
205921005370	ribonuclease HIII; Provisional; Region: PRK00996
205921005371	Domain of unknown function (DUF3378); Region: DUF3378; pfam11858
205921005372	bacterial Ribonuclease HIII-like; Region: RNase_HII_bacteria_HIII_like; cd06590
205921005373	RNA/DNA hybrid binding site [nucleotide binding]; other site
205921005374	active site
205921005375	signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227
205921005376	The S24, S26 LexA/signal peptidase superfamily contains LexA-related and type I signal peptidase families. The S24 LexA protein domains include: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC 3.4.21.88), the...; Region: Peptidase_S24_S26; cd06462
205921005377	Catalytic site [active]
205921005378	helicase, putative, RecD/TraA family; Region: recD_rel; TIGR01448
205921005379	AAA domain; Region: AAA_30; pfam13604
205921005380	Family description; Region: UvrD_C_2; pfam13538
205921005381	DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586
205921005382	active site
205921005383	DNA polymerase IV; Validated; Region: PRK02406
205921005384	DNA binding site [nucleotide binding]
205921005385	formate acetyltransferase 1; Region: pyr_form_ly_1; TIGR01255
205921005386	Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939
205921005387	Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243
205921005388	Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680
205921005389	Beta-lactamase; Region: Beta-lactamase; pfam00144
205921005390	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587
205921005391	active site
205921005392	Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cd00333
205921005393	amphipathic channel; other site
205921005394	Asn-Pro-Ala signature motifs; other site
205921005395	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
205921005396	Ligand Binding Site [chemical binding]; other site
205921005397	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
205921005398	Major Facilitator Superfamily; Region: MFS_1; pfam07690
205921005399	putative substrate translocation pore; other site
205921005400	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
205921005401	helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cl17320
205921005402	x-prolyl-dipeptidyl aminopeptidase; Provisional; Region: PRK05371
205921005403	X-Prolyl dipeptidyl aminopeptidase PepX, N-terminal; Region: PepX_N; pfam09168
205921005404	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
205921005405	X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain; Region: PepX_C; pfam08530
205921005406	Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142
205921005407	Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685
205921005408	substrate binding pocket [chemical binding]; other site
205921005409	chain length determination region; other site
205921005410	substrate-Mg2+ binding site; other site
205921005411	catalytic residues [active]
205921005412	aspartate-rich region 1; other site
205921005413	active site lid residues [active]
205921005414	aspartate-rich region 2; other site
205921005415	ABC-type transport system involved in cytochrome bd biosynthesis, fused ATPase and permease components [Energy production and conversion / Posttranslational modification, protein turnover, chaperones]; Region: CydC; COG4987
205921005416	ATP-binding cassette domain of CydCD, subfamily C; Region: ABCC_cytochrome_bd; cd03247
205921005417	Walker A/P-loop; other site
205921005418	ATP binding site [chemical binding]; other site
205921005419	Q-loop/lid; other site
205921005420	ABC transporter signature motif; other site
205921005421	Walker B; other site
205921005422	D-loop; other site
205921005423	H-loop/switch region; other site
205921005424	ABC-type transport system involved in cytochrome bd biosynthesis, ATPase and permease components [Energy production and conversion / Posttranslational modification, protein turnover, chaperones]; Region: CydD; COG4988
205921005425	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
205921005426	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
205921005427	Walker A/P-loop; other site
205921005428	ATP binding site [chemical binding]; other site
205921005429	Q-loop/lid; other site
205921005430	ABC transporter signature motif; other site
205921005431	Walker B; other site
205921005432	D-loop; other site
205921005433	H-loop/switch region; other site
205921005434	Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322
205921005435	cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219
205921005436	cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219
205921005437	Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; pfam01654
205921005438	NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252
205921005439	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
205921005440	1,4-dihydroxy-2-naphthoate octaprenyltransferase; Validated; Region: PRK06080
205921005441	UbiA prenyltransferase family; Region: UbiA; pfam01040
205921005442	Type I restriction-modification system methyltransferase subunit [Defense mechanisms]; Region: HsdM; COG0286
205921005443	HsdM N-terminal domain; Region: HsdM_N; pfam12161
205921005444	Methyltransferase domain; Region: Methyltransf_26; pfam13659
205921005445	Transketolase [Carbohydrate transport and metabolism]; Region: TktA; COG0021
205921005446	Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012
205921005447	TPP-binding site [chemical binding]; other site
205921005448	dimer interface [polypeptide binding]; other site
205921005449	Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033
205921005450	PYR/PP interface [polypeptide binding]; other site
205921005451	dimer interface [polypeptide binding]; other site
205921005452	TPP binding site [chemical binding]; other site
205921005453	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
205921005454	Transaldolase-like fructose-6-phosphate aldolases (FSA) found in bacteria and archaea; Region: Transaldolase_FSA; cd00956
205921005455	active site
205921005456	intersubunit interactions; other site
205921005457	catalytic residue [active]
205921005458	Pentose-5-phosphate-3-epimerase [Carbohydrate transport and metabolism]; Region: Rpe; COG0036
205921005459	Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429
205921005460	substrate binding site [chemical binding]; other site
205921005461	hexamer interface [polypeptide binding]; other site
205921005462	metal binding site [ion binding]; metal-binding site
205921005463	Phosphotransferase system, fructose-specific IIC component [Carbohydrate transport and metabolism]; Region: FruA; COG1299
205921005464	Phosphotransferase system, EIIC; Region: PTS_EIIC; pfam02378
205921005465	PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211
205921005466	active site
205921005467	phosphorylation site [posttranslational modification]
205921005468	PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569
205921005469	active site
205921005470	P-loop; other site
205921005471	phosphorylation site [posttranslational modification]
205921005472	Transcriptional antiterminator [Transcription]; Region: BglG; COG3711
205921005473	HTH domain; Region: HTH_11; pfam08279
205921005474	PRD domain; Region: PRD; pfam00874
205921005475	PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568
205921005476	active site
205921005477	P-loop; other site
205921005478	phosphorylation site [posttranslational modification]
205921005479	PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211
205921005480	active site
205921005481	phosphorylation site [posttranslational modification]
205921005482	Uncharacterized protein family (UPF0157); Region: UPF0157; pfam04229
205921005483	Predicted epimerase, PhzC/PhzF homolog [General function prediction only]; Region: COG0384
205921005484	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
205921005485	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
205921005486	hypothetical protein; Validated; Region: PRK00153
205921005487	Cyclopropane fatty acid synthase and related methyltransferases [Cell envelope biogenesis, outer membrane]; Region: Cfa; COG2230
205921005488	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
205921005489	S-adenosylmethionine binding site [chemical binding]; other site
205921005490	Helix-Turn-Helix DNA binding domain of the transcription regulators TipAL, Mta, and SkgA; Region: HTH_TipAL-Mta; cd01106
205921005491	MerR HTH family regulatory protein; Region: MerR_1; pfam13411
205921005492	DNA binding residues [nucleotide binding]
205921005493	dimer interface [polypeptide binding]; other site
205921005494	DNA polymerase III, epsilon subunit and related 3'-5' exonucleases [DNA replication, recombination, and repair]; Region: DnaQ; COG0847
205921005495	DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127
205921005496	active site
205921005497	catalytic site [active]
205921005498	substrate binding site [chemical binding]; other site
205921005499	HI0933-like protein; Region: HI0933_like; pfam03486
205921005500	hydroxyglutarate oxidase; Provisional; Region: PRK11728
205921005501	HIT family: HIT (Histidine triad) proteins, named for a motif related to the sequence HxHxH/Qxx (x, a hydrophobic amino acid), are a superfamily of nucleotide hydrolases and transferases, which act on the alpha-phosphate of ribonucleotides. On the basis...; Region: HIT_like; cl00228
205921005502	nucleotide binding site/active site [active]
205921005503	HIT family signature motif; other site
205921005504	catalytic residue [active]
205921005505	30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08881
205921005506	Threonine aldolase [Amino acid transport and metabolism]; Region: GLY1; COG2008
205921005507	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
205921005508	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
205921005509	catalytic residue [active]
205921005510	UGMP family protein; Validated; Region: PRK09604
205921005511	Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214; cl17884
205921005512	Carbamoyltransferase; Region: CmcH_NodU; pfam02543
205921005513	ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575
205921005514	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
205921005515	Coenzyme A binding pocket [chemical binding]; other site
205921005516	tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725
205921005517	Glycoprotease family; Region: Peptidase_M22; pfam00814
205921005518	hypothetical protein; Provisional; Region: PRK13667
205921005519	mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595
205921005520	Metallo-beta-lactamase superfamily; Region: Lactamase_B; pfam00753
205921005521	RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521
205921005522	CHAP domain; Region: CHAP; cl17642
205921005523	Surface antigen [General function prediction only]; Region: COG3942
205921005524	Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174
205921005525	Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951
205921005526	Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120
205921005527	Helix-Turn-Helix DNA binding domain of GlnR-like transcription regulators; Region: HTH_GlnR-like; cd01105
205921005528	MerR HTH family regulatory protein; Region: MerR_1; pfam13411
205921005529	DNA binding residues [nucleotide binding]
205921005530	putative dimer interface [polypeptide binding]; other site
205921005531	Predicted membrane protein [Function unknown]; Region: COG4129
205921005532	Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515
205921005533	phosphoglycerate kinase; Provisional; Region: pgk; PRK00073
205921005534	Phosphoglycerate kinase; Region: PGK; pfam00162
205921005535	substrate binding site [chemical binding]; other site
205921005536	hinge regions; other site
205921005537	ADP binding site [chemical binding]; other site
205921005538	catalytic site [active]
205921005539	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
205921005540	active site
205921005541	motif I; other site
205921005542	haloacid dehalogenase-like hydrolase; Region: Hydrolase; pfam00702
205921005543	motif II; other site
205921005544	Glyceraldehyde-3-phosphate dehydrogenase/erythrose-4-phosphate dehydrogenase [Carbohydrate transport and metabolism]; Region: GapA; COG0057
205921005545	Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846
205921005546	Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800
205921005547	elongation factor G; Reviewed; Region: PRK00007
205921005548	Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886
205921005549	G1 box; other site
205921005550	putative GEF interaction site [polypeptide binding]; other site
205921005551	GTP/Mg2+ binding site [chemical binding]; other site
205921005552	Switch I region; other site
205921005553	G2 box; other site
205921005554	G3 box; other site
205921005555	Switch II region; other site
205921005556	G4 box; other site
205921005557	G5 box; other site
205921005558	EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088
205921005559	EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434
205921005560	EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G.  Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713
205921005561	30S ribosomal protein S7; Validated; Region: PRK05302
205921005562	S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368
205921005563	S17 interaction site [polypeptide binding]; other site
205921005564	S8 interaction site; other site
205921005565	16S rRNA interaction site [nucleotide binding]; other site
205921005566	streptomycin interaction site [chemical binding]; other site
205921005567	23S rRNA interaction site [nucleotide binding]; other site
205921005568	aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site
205921005569	pur operon repressor; Provisional; Region: PRK09213
205921005570	Bacterial purine repressor, N-terminal; Region: PuR_N; pfam09182
205921005571	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
205921005572	active site
205921005573	Predicted HD-superfamily hydrolase [General function prediction only]; Region: COG3481
205921005574	YhaM_OBF_like: A subfamily of OB folds similar to that found in Bacillus subtilis YhaM and Staphylococcus aureus cmp-binding factor-1 (SaCBF1). Both these proteins are 3'-to-5'exoribonucleases. YhaM requires Mn2+ or Co2+ for activity and is...; Region: YhaM_OBF_like; cd04492
205921005575	generic binding surface II; other site
205921005576	generic binding surface I; other site
205921005577	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
205921005578	Zn2+ binding site [ion binding]; other site
205921005579	Mg2+ binding site [ion binding]; other site
205921005580	Predicted nuclease of restriction endonuclease-like fold, RmuC family [General function prediction only]; Region: COG1322
205921005581	RmuC family; Region: RmuC; pfam02646
205921005582	Thiamine pyrophosphokinase; Region: TPK; cd07995
205921005583	thiamine pyrophosphokinase; Region: thi_PPkinase; TIGR01378
205921005584	active site
205921005585	dimerization interface [polypeptide binding]; other site
205921005586	thiamine binding site [chemical binding]; other site
205921005587	Pentose-5-phosphate-3-epimerase [Carbohydrate transport and metabolism]; Region: Rpe; COG0036
205921005588	Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429
205921005589	substrate binding site [chemical binding]; other site
205921005590	hexamer interface [polypeptide binding]; other site
205921005591	metal binding site [ion binding]; metal-binding site
205921005592	GTPase RsgA; Reviewed; Region: PRK00098
205921005593	S1_YloQ_GTPase: YloQ GTase family (also known as YjeQ and CpgA), S1-like RNA-binding domain. Proteins in the YloQ GTase family bind the ribosome and have GTPase activity. The precise role of this family is unknown. The protein structure is composed of...; Region: S1_YloQ_GTPase; cd04466
205921005594	RNA binding site [nucleotide binding]; other site
205921005595	homodimer interface [polypeptide binding]; other site
205921005596	Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854
205921005597	GTPase/Zn-binding domain interface [polypeptide binding]; other site
205921005598	GTP/Mg2+ binding site [chemical binding]; other site
205921005599	G4 box; other site
205921005600	G1 box; other site
205921005601	Switch I region; other site
205921005602	G2 box; other site
205921005603	G3 box; other site
205921005604	Switch II region; other site
205921005605	Methyltransferase domain; Region: Methyltransf_31; pfam13847
205921005606	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
205921005607	S-adenosylmethionine binding site [chemical binding]; other site
205921005608	16S ribosomal RNA methyltransferase KsgA/Dim1 family protein; Reviewed; Region: ksgA; PRK00274
205921005609	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
205921005610	S-adenosylmethionine binding site [chemical binding]; other site
205921005611	Diadenosine tetraphosphate (Ap4A) hydrolase and other HIT family hydrolases [Nucleotide transport and metabolism / Carbohydrate transport and metabolism / General function prediction only]; Region: Hit; COG0537
205921005612	nucleotide binding site/active site [active]
205921005613	HIT family signature motif; other site
205921005614	catalytic residue [active]
205921005615	ribonuclease M5; Region: 5S_RNA_mat_M5; TIGR00334
205921005616	TOPRIM_ RNase M5_like: The topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain found in Ribonuclease M5: (RNase M5) and other small primase-like proteins from bacteria and archaea.  RNase M5 catalyzes the maturation of 5S rRNA in low...; Region: TOPRIM_RNase_M5_like; cd01027
205921005617	putative active site [active]
205921005618	putative metal binding site [ion binding]; other site
205921005619	Domain of unknown function (DUF4093); Region: DUF4093; pfam13331
205921005620	TatD like proteins;  E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310
205921005621	Predicted metal-dependent hydrolases with the TIM-barrel fold [General function prediction only]; Region: COG1099
205921005622	active site
205921005623	triacylglycerol lipase; Region: PLN00413
205921005624	Protein of unknown function (DUF1310); Region: DUF1310; pfam07006
205921005625	DltD N-terminal region; Region: DltD_N; pfam04915
205921005626	D-alanyl-lipoteichoic acid biosynthesis protein DltD; Region: LTA_DltD; TIGR04092
205921005627	DltD central region; Region: DltD_M; pfam04918
205921005628	DltD C-terminal region; Region: DltD_C; pfam04914
205921005629	D-alanine--poly(phosphoribitol) ligase subunit 2; Validated; Region: PRK05087
205921005630	D-alanyl-lipoteichoic acid biosynthesis protein DltB; Region: LTA_dltB; TIGR04091
205921005631	D-alanine--poly(phosphoribitol) ligase subunit 1; Provisional; Region: PRK04813
205921005632	D-alanine:D-alanyl carrier protein ligase (DltA); Region: DltA; cd05945
205921005633	acyl-activating enzyme (AAE) consensus motif; other site
205921005634	AMP binding site [chemical binding]; other site
205921005635	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
205921005636	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
205921005637	dimer interface [polypeptide binding]; other site
205921005638	phosphorylation site [posttranslational modification]
205921005639	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
205921005640	ATP binding site [chemical binding]; other site
205921005641	Mg2+ binding site [ion binding]; other site
205921005642	G-X-G motif; other site
205921005643	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
205921005644	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
205921005645	active site
205921005646	phosphorylation site [posttranslational modification]
205921005647	intermolecular recognition site; other site
205921005648	dimerization interface [polypeptide binding]; other site
205921005649	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
205921005650	DNA binding site [nucleotide binding]
205921005651	50S ribosomal protein L34; Reviewed; Region: rpmH; PRK00399
205921005652	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3314
205921005653	Nucleoside recognition; Region: Gate; pfam07670
205921005654	ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600
205921005655	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
205921005656	dimer interface [polypeptide binding]; other site
205921005657	conserved gate region; other site
205921005658	putative PBP binding loops; other site
205921005659	ABC-ATPase subunit interface; other site
205921005660	ABC-type proline/glycine betaine transport systems, periplasmic components [Amino acid transport and metabolism]; Region: ProX; COG2113
205921005661	Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069
205921005662	ABC-type proline/glycine betaine transport system, ATPase component [Amino acid transport and metabolism]; Region: ProV; COG4175
205921005663	ATP-binding cassette domain of the osmoprotectant proline/glycine betaine uptake system; Region: ABC_Pro_Gly_Betaine; cd03294
205921005664	Walker A/P-loop; other site
205921005665	ATP binding site [chemical binding]; other site
205921005666	Q-loop/lid; other site
205921005667	ABC transporter signature motif; other site
205921005668	Walker B; other site
205921005669	D-loop; other site
205921005670	H-loop/switch region; other site
205921005671	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354
205921005672	XFP N-terminal domain; Region: XFP_N; pfam09364
205921005673	putative phosphoketolase; Provisional; Region: PRK05261
205921005674	XFP C-terminal domain; Region: XFP_C; pfam09363
205921005675	putative L-ascorbate 6-phosphate lactonase; Provisional; Region: PRK11709
205921005676	Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220
205921005677	Transcriptional antiterminator [Transcription]; Region: BglG; COG3711
205921005678	PRD domain; Region: PRD; pfam00874
205921005679	PRD domain; Region: PRD; pfam00874
205921005680	PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568
205921005681	active site
205921005682	P-loop; other site
205921005683	phosphorylation site [posttranslational modification]
205921005684	Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261
205921005685	Sugar (pentulose and hexulose) kinases [Carbohydrate transport and metabolism]; Region: XylB; COG1070
205921005686	L-xylulose kinases; a subfamily of the FGGY family of carbohydrate kinases; Region: FGGY_L-XK; cd07802
205921005687	putative N- and C-terminal domain interface [polypeptide binding]; other site
205921005688	putative active site [active]
205921005689	MgATP binding site [chemical binding]; other site
205921005690	catalytic site [active]
205921005691	metal binding site [ion binding]; metal-binding site
205921005692	putative xylulose binding site [chemical binding]; other site
205921005693	Predicted metal-dependent hydrolase of the TIM-barrel fold [General function prediction only]; Region: COG3618
205921005694	Amidohydrolase; Region: Amidohydro_2; pfam04909
205921005695	Phosphotransferase system, galactitol-specific IIC component [Carbohydrate transport and metabolism]; Region: GatC; COG3775
205921005696	PTS system sugar-specific permease component; Region: EIIC-GAT; pfam03611
205921005697	Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052
205921005698	Putative D-isomer specific 2-hydroxyacid dehydrogenases, NAD-binding and catalytic domains; Region: 2-Hacid_dh_13; cd12178
205921005699	putative ligand binding site [chemical binding]; other site
205921005700	putative NAD binding site [chemical binding]; other site
205921005701	catalytic site [active]
205921005702	Transcriptional regulators [Transcription]; Region: PurR; COG1609
205921005703	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
205921005704	DNA binding site [nucleotide binding]
205921005705	domain linker motif; other site
205921005706	Ligand-binding domain of DNA transcription repressor RegR and other putative regulators such as KdgR and EndR; Region: PBP1_RegR_EndR_KdgR_like; cd06283
205921005707	putative dimerization interface [polypeptide binding]; other site
205921005708	putative ligand binding site [chemical binding]; other site
205921005709	Transaldolase-like fructose-6-phosphate aldolases (FSA) found in bacteria and archaea; Region: Transaldolase_FSA; cd00956
205921005710	active site
205921005711	intersubunit interactions; other site
205921005712	catalytic residue [active]
205921005713	L-ribulose-5-phosphate 4-epimerase; Reviewed; Region: araD; PRK08193
205921005714	Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cd00398
205921005715	intersubunit interface [polypeptide binding]; other site
205921005716	active site
205921005717	Zn2+ binding site [ion binding]; other site
205921005718	putative L-xylulose 5-phosphate 3-epimerase; Reviewed; Region: PRK13210
205921005719	AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cd00019
205921005720	AP (apurinic/apyrimidinic) site pocket; other site
205921005721	DNA interaction; other site
205921005722	Metal-binding active site; metal-binding site
205921005723	3-Keto-L-gulonate 6-phosphate decarboxylase (KGPDC) and D-arabino-3-hexulose-6-phosphate synthase (HPS). KGPDC catalyzes the formation of L-xylulose 5-phosphate and carbon dioxide from 3-keto-L-gulonate 6-phosphate as part of the anaerobic pathway for...; Region: KGPDC_HPS; cd04726
205921005724	active site
205921005725	dimer interface [polypeptide binding]; other site
205921005726	magnesium binding site [ion binding]; other site
205921005727	PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211
205921005728	active site
205921005729	phosphorylation site [posttranslational modification]
205921005730	PTS_IIB_ascorbate: subunit IIB of enzyme II (EII) of the L-ascorbate-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is an L-ascorbate-specific permease with two cytoplasmic subunits (IIA and IIB) and a...; Region: PTS_IIB_ascorbate; cd05563
205921005731	active site
205921005732	P-loop; other site
205921005733	phosphorylation site [posttranslational modification]
205921005734	PTS system ascorbate-specific transporter subunit IIC; Reviewed; Region: PRK12997
205921005735	L-aminoadipate-semialdehyde dehydrogenase; Region: alpha_am_amid; TIGR03443
205921005736	Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788
205921005737	Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108
205921005738	GDP-binding site [chemical binding]; other site
205921005739	ACT binding site; other site
205921005740	IMP binding site; other site
205921005741	Phosphotransferase system, fructose-specific IIC component [Carbohydrate transport and metabolism]; Region: FruA; COG1299
205921005742	Phosphotransferase system, EIIC; Region: PTS_EIIC_2; pfam13303
205921005743	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2964
205921005744	YheO-like PAS domain; Region: PAS_6; pfam08348
205921005745	HTH domain; Region: HTH_22; pfam13309
205921005746	bifunctional glutamate--cysteine ligase/glutathione synthetase; Provisional; Region: PRK02471
205921005747	Glutamate-cysteine ligase; Region: Glu_cys_ligase; cl17352
205921005748	ATP-grasp domain; Region: ATP-grasp_4; cl17255
205921005749	Positive regulator of sigma(E), RseC/MucC; Region: RseC_MucC; cl01178
205921005750	Uncharacterized protein involved in tellurite resistance [Inorganic ion transport and metabolism]; Region: TelA; COG3853
205921005751	Hsp33-like chaperonin; Reviewed; Region: hslO; PRK00114
205921005752	Heat shock protein 33 (Hsp33):  Cytosolic protein that acts as a molecular chaperone under oxidative conditions.  In normal (reducing) cytosolic conditions, four conserved Cys residues are coordinated by a Zn ion. Under oxidative stress (such as heat...; Region: Hsp33; cd00498
205921005753	dimerization interface [polypeptide binding]; other site
205921005754	domain crossover interface; other site
205921005755	redox-dependent activation switch; other site
205921005756	putative TIM-barrel protein, nifR3 family; Region: nifR3_yhdG; TIGR00737
205921005757	Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801
205921005758	FMN binding site [chemical binding]; other site
205921005759	active site
205921005760	catalytic residues [active]
205921005761	substrate binding site [chemical binding]; other site
205921005762	Deoxynucleoside kinases [Nucleotide transport and metabolism]; Region: COG1428
205921005763	Deoxyribonucleoside kinase (dNK) catalyzes the phosphorylation of deoxyribonucleosides to yield corresponding monophosphates (dNMPs). This family consists of various deoxynucleoside kinases including deoxyribo- cytidine (EC 2.7.1.74), guanosine (EC 2.7.1; Region: dNK; cd01673
205921005764	Substrate-binding site [chemical binding]; other site
205921005765	Substrate specificity [chemical binding]; other site
205921005766	Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247
205921005767	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
205921005768	Coenzyme A binding pocket [chemical binding]; other site
205921005769	ATP-binding subunits of Clp protease and DnaK/DnaJ chaperones [Posttranslational modification, protein turnover, chaperones]; Region: clpA; COG0542
205921005770	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
205921005771	Walker A motif; other site
205921005772	ATP binding site [chemical binding]; other site
205921005773	Walker B motif; other site
205921005774	arginine finger; other site
205921005775	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
205921005776	Walker A motif; other site
205921005777	ATP binding site [chemical binding]; other site
205921005778	Walker B motif; other site
205921005779	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431
205921005780	Firmicute transcriptional repressor of class III stress genes (CtsR); Region: CtsR; pfam05848
205921005781	Putative small multi-drug export protein; Region: Sm_multidrug_ex; pfam06695
205921005782	elongation factor Ts; Provisional; Region: tsf; PRK09377
205921005783	UBA/TS-N domain; Region: UBA; pfam00627
205921005784	Elongation factor TS; Region: EF_TS; pfam00889
205921005785	Elongation factor TS; Region: EF_TS; pfam00889
205921005786	Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425
205921005787	rRNA interaction site [nucleotide binding]; other site
205921005788	S8 interaction site; other site
205921005789	putative laminin-1 binding site; other site
205921005790	peroxiredoxin; Region: AhpC; TIGR03137
205921005791	Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015
205921005792	dimer interface [polypeptide binding]; other site
205921005793	decamer (pentamer of dimers) interface [polypeptide binding]; other site
205921005794	catalytic triad [active]
205921005795	peroxidatic and resolving cysteines [active]
205921005796	alkyl hydroperoxide reductase subunit F; Provisional; Region: PRK15317
205921005797	Alkyl hydroperoxide reductase F subunit (AhpF) N-terminal domain (NTD) family, N-terminal TRX-fold subdomain; AhpF is a homodimeric flavoenzyme which catalyzes the NADH-dependent reduction of the peroxiredoxin AhpC, which in turn catalyzes the reduction...; Region: AhpF_NTD_N; cd02974
205921005798	catalytic residue [active]
205921005799	TRX-GRX-like family, Alkyl hydroperoxide reductase F subunit (AhpF) N-terminal domain (NTD) subfamily, C-terminal TRX-fold subdomain; AhpF is a homodimeric flavoenzyme which catalyzes the NADH-dependent reduction of the peroxiredoxin AhpC, which then...; Region: AhpF_NTD_C; cd03026
205921005800	catalytic residues [active]
205921005801	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
205921005802	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
205921005803	NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025
205921005804	Microcin C7 self-immunity protein determines resistance to exogenous microcin C7; Region: Peptidase_S66_mccF_like; cd07062
205921005805	putative dimer interface [polypeptide binding]; other site
205921005806	catalytic triad [active]
205921005807	Predicted metalloendopeptidase [Posttranslational modification, protein turnover, chaperones]; Region: PepO; COG3590
205921005808	Peptidase family M13 includes neprilysin, endothelin-converting enzyme I; Region: M13; cd08662
205921005809	active site
205921005810	Zn binding site [ion binding]; other site
205921005811	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
205921005812	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
205921005813	Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894
205921005814	DNA-binding transcriptional activator YeiL; Provisional; Region: PRK10402
205921005815	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
205921005816	ligand binding site [chemical binding]; other site
205921005817	helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cl17320
205921005818	Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487
205921005819	active site
205921005820	catalytic residues [active]
205921005821	metal binding site [ion binding]; metal-binding site
205921005822	Transcriptional regulators [Transcription]; Region: PurR; COG1609
205921005823	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
205921005824	DNA binding site [nucleotide binding]
205921005825	domain linker motif; other site
205921005826	Ligand-binding domain of DNA transcription repressor RegR and other putative regulators such as KdgR and EndR; Region: PBP1_RegR_EndR_KdgR_like; cd06283
205921005827	putative dimerization interface [polypeptide binding]; other site
205921005828	putative ligand binding site [chemical binding]; other site
205921005829	Heparinase II/III-like protein; Region: Hepar_II_III; pfam07940
205921005830	Nitroreductase-like family 4.  A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_4; cd02140
205921005831	dimer interface [polypeptide binding]; other site
205921005832	FMN binding site [chemical binding]; other site
205921005833	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
205921005834	MarR family; Region: MarR; pfam01047
205921005835	MarR family; Region: MarR_2; cl17246
205921005836	DNA polymerase III PolC; Validated; Region: polC; PRK00448
205921005837	DNA polymerase III polC-type N-terminus; Region: DNA_pol3_alph_N; pfam11490
205921005838	polC_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold nucleic acid binding domain of Bacillus subtilis type C replicative DNA polymerase III alpha subunit (polC). Replication in B. subtilis and Staphylococcus aureus requires two...; Region: polC_OBF; cd04484
205921005839	generic binding surface II; other site
205921005840	generic binding surface I; other site
205921005841	Polymerase and Histidinol Phosphatase domain; Region: PHP; cl17102
205921005842	active site
205921005843	DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127
205921005844	active site
205921005845	catalytic site [active]
205921005846	substrate binding site [chemical binding]; other site
205921005847	Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III at PolC gene; Region: PHP_PolIIIA_POLC; cd07435
205921005848	Muramidase (flagellum-specific) [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FlgJ; COG1705
205921005849	prolyl-tRNA synthetase; Provisional; Region: PRK09194
205921005850	Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA.   PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268
205921005851	motif 1; other site
205921005852	dimer interface [polypeptide binding]; other site
205921005853	active site
205921005854	motif 2; other site
205921005855	INS is an amino acid-editing domain inserted (INS) into the bacterial class II prolyl-tRNA synthetase (ProRS) however, this CD is not exclusively bacterial. It is also found at the N-terminus of the eukaryotic/archaea-like ProRS's of yeasts and...; Region: ProRS-INS; cd04334
205921005856	putative deacylase active site [active]
205921005857	Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA.   PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268
205921005858	active site
205921005859	motif 3; other site
205921005860	ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding; Region: ProRS_anticodon_short; cd00861
205921005861	anticodon binding site; other site
205921005862	RIP metalloprotease RseP; Region: TIGR00054
205921005863	Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020
205921005864	Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020
205921005865	PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989
205921005866	protein binding site [polypeptide binding]; other site
205921005867	RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163
205921005868	putative substrate binding region [chemical binding]; other site
205921005869	CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575
205921005870	Cytidylyltransferase family; Region: CTP_transf_1; pfam01148
205921005871	Undecaprenyl pyrophosphate synthase [Lipid metabolism]; Region: UppS; COG0020
205921005872	Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cd00475
205921005873	catalytic residue [active]
205921005874	putative FPP diphosphate  binding site; other site
205921005875	putative FPP binding hydrophobic cleft; other site
205921005876	dimer interface [polypeptide binding]; other site
205921005877	putative IPP diphosphate binding site; other site
205921005878	preprotein translocase subunit YajC; Validated; Region: yajC; PRK06531
205921005879	TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947
205921005880	catalytic residues [active]
205921005881	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3666
205921005882	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
205921005883	Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751
205921005884	Malic enzyme [Energy production and conversion]; Region: SfcA; COG0281
205921005885	Malic enzyme, N-terminal domain; Region: malic; pfam00390
205921005886	NAD(P) binding domain of malic enzyme (ME), subgroup 2; Region: NAD_bind_2_malic_enz; cd05311
205921005887	putative NAD(P) binding site [chemical binding]; other site
205921005888	2-hydroxycarboxylate transporter family; Region: 2HCT; pfam03390
205921005889	PAS domain; Region: PAS_9; pfam13426
205921005890	Response regulator of citrate/malate metabolism [Transcription / Signal transduction mechanisms]; Region: CitB; COG4565
205921005891	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
205921005892	active site
205921005893	phosphorylation site [posttranslational modification]
205921005894	intermolecular recognition site; other site
205921005895	dimerization interface [polypeptide binding]; other site
205921005896	UDP-glucose 4-epimerase [Cell envelope biogenesis, outer membrane]; Region: GalE; COG1087
205921005897	UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247
205921005898	NAD binding site [chemical binding]; other site
205921005899	homodimer interface [polypeptide binding]; other site
205921005900	active site
205921005901	substrate binding site [chemical binding]; other site
205921005902	alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403
205921005903	Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333
205921005904	Ca binding site [ion binding]; other site
205921005905	active site
205921005906	catalytic site [active]
205921005907	Domain of unknown function (DUF3459); Region: DUF3459; pfam11941
205921005908	glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650
205921005909	The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301
205921005910	Walker A/P-loop; other site
205921005911	ATP binding site [chemical binding]; other site
205921005912	Q-loop/lid; other site
205921005913	ABC transporter signature motif; other site
205921005914	Walker B; other site
205921005915	D-loop; other site
205921005916	H-loop/switch region; other site
205921005917	TOBE domain; Region: TOBE_2; pfam08402
205921005918	Regulator of polyketide synthase expression [Signal transduction mechanisms / Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2508
205921005919	PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556
205921005920	Aldose 1-epimerase, similar to Lactococcus lactis lacX; Region: Aldose_epim_lacX; cd09024
205921005921	active site
205921005922	catalytic residues [active]
205921005923	tagatose 1,6-diphosphate aldolase; Reviewed; Region: PRK12399
205921005924	1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164
205921005925	tagatose-6-phosphate kinase; Region: lacC; TIGR01231
205921005926	putative substrate binding site [chemical binding]; other site
205921005927	putative ATP binding site [chemical binding]; other site
205921005928	galactose-6-phosphate isomerase subunit LacB; Reviewed; Region: PRK08622
205921005929	galactose-6-phosphate isomerase subunit LacA; Reviewed; Region: PRK08621
205921005930	Sialidases or neuraminidases function to bind and hydrolyze terminal sialic acid residues from various glycoconjugates as well as playing roles in pathogenesis, bacterial nutrition and cellular interactions. They have a six-bladed, beta-propeller fold...; Region: Sialidase; cd00260
205921005931	Sialidases or neuraminidases function to bind and hydrolyze terminal sialic acid residues from various glycoconjugates as well as playing roles in pathogenesis, bacterial nutrition and cellular interactions. They have a six-bladed, beta-propeller fold...; Region: Sialidase; cd00260
205921005932	Asp-box motif; other site
205921005933	Asp-box motif; other site
205921005934	catalytic site [active]
205921005935	Phosphotransferase system, galactitol-specific IIC component [Carbohydrate transport and metabolism]; Region: GatC; COG3775
205921005936	PTS system sugar-specific permease component; Region: EIIC-GAT; cl04451
205921005937	Phosphotransferase system, galactitol-specific IIB component [Carbohydrate transport and metabolism]; Region: SgaB; COG3414
205921005938	active site
205921005939	P-loop; other site
205921005940	phosphorylation site [posttranslational modification]
205921005941	PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211
205921005942	active site
205921005943	phosphorylation site [posttranslational modification]
205921005944	Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349
205921005945	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
205921005946	DNA-binding site [nucleotide binding]; DNA binding site
205921005947	DeoR C terminal sensor domain; Region: DeoRC; pfam00455
205921005948	streptococcal histidine triad protein; Region: strep_his_triad; TIGR01363
205921005949	Streptococcal histidine triad protein; Region: Strep_his_triad; pfam04270
205921005950	Streptococcal histidine triad protein; Region: Strep_his_triad; pfam04270
205921005951	Streptococcal histidine triad protein; Region: Strep_his_triad; pfam04270
205921005952	ABC-type metal ion transport system, periplasmic component/surface adhesin [Inorganic ion transport and metabolism]; Region: LraI; COG0803
205921005953	Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+.  Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262
205921005954	intersubunit interface [polypeptide binding]; other site
205921005955	D-Tyrosyl-tRNAtyr deacylases; a class of tRNA-dependent hydrolases which are capable of hydrolyzing the ester bond of D-Tyrosyl-tRNA reducing the level of cellular D-Tyrosine while recycling the peptidyl-tRNA; found in bacteria and in eukaryotes but not...; Region: Dtyr_deacylase; cd00563
205921005956	putative active site [active]
205921005957	dimerization interface [polypeptide binding]; other site
205921005958	putative tRNAtyr binding site [nucleotide binding]; other site
205921005959	Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317
205921005960	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
205921005961	Zn2+ binding site [ion binding]; other site
205921005962	Mg2+ binding site [ion binding]; other site
205921005963	Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399
205921005964	synthetase active site [active]
205921005965	NTP binding site [chemical binding]; other site
205921005966	metal binding site [ion binding]; metal-binding site
205921005967	TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668
205921005968	ACT  domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876
205921005969	bifunctional 2',3'-cyclic nucleotide 2'-phosphodiesterase/3'-nucleotidase precursor protein; Reviewed; Region: PRK11907
205921005970	Escherichia coli CpdB and related proteins, N-terminal metallophosphatase domain; Region: MPP_CpdB_N; cd07410
205921005971	active site
205921005972	metal binding site [ion binding]; metal-binding site
205921005973	5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872
205921005974	Gram positive anchor; Region: Gram_pos_anchor; pfam00746
205921005975	flavoprotein NrdI; Provisional; Region: PRK02551
205921005976	Cellulase M and related proteins [Carbohydrate transport and metabolism]; Region: FrvX; COG1363
205921005977	M42 Peptidase, Endoglucanase-like subfamily; Region: M42_glucanase_like; cd05657
205921005978	putative oligomer interface [polypeptide binding]; other site
205921005979	putative active site [active]
205921005980	metal binding site [ion binding]; metal-binding site
205921005981	AAA domain; Region: AAA_33; pfam13671
205921005982	Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cd02019
205921005983	active site
205921005984	ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840
205921005985	Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416
205921005986	Response regulator receiver domain; Region: Response_reg; pfam00072
205921005987	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
205921005988	active site
205921005989	phosphorylation site [posttranslational modification]
205921005990	intermolecular recognition site; other site
205921005991	dimerization interface [polypeptide binding]; other site
205921005992	AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207
205921005993	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
205921005994	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
205921005995	Predicted signal transduction protein with a C-terminal ATPase domain [Signal transduction mechanisms]; Region: COG2972
205921005996	Histidine kinase; Region: His_kinase; pfam06580
205921005997	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
205921005998	ATP binding site [chemical binding]; other site
205921005999	Mg2+ binding site [ion binding]; other site
205921006000	G-X-G motif; other site
205921006001	Phosphotransferase system, mannose/fructose/N-acetylgalactosamine-specific component IID [Carbohydrate transport and metabolism]; Region: ManZ; COG3716
205921006002	Phosphotransferase system, mannose/fructose/N-acetylgalactosamine-specific component IIC [Carbohydrate transport and metabolism]; Region: ManY; COG3715
205921006003	PTS system sorbose subfamily IIB component; Region: PTSIIB_sorb; pfam03830
205921006004	active site
205921006005	phosphorylation site [posttranslational modification]
205921006006	PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cl00025
205921006007	active pocket/dimerization site; other site
205921006008	active site
205921006009	phosphorylation site [posttranslational modification]
205921006010	ABC-2 family transporter protein; Region: ABC2_membrane_2; cl17866
205921006011	Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various bacteriocins (mostly non-lantibiotic); Region: Peptidase_C39_like; cl00296
205921006012	putative active site [active]
205921006013	Predicted signal transduction protein with a C-terminal ATPase domain [Signal transduction mechanisms]; Region: COG2972
205921006014	Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279
205921006015	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
205921006016	active site
205921006017	phosphorylation site [posttranslational modification]
205921006018	intermolecular recognition site; other site
205921006019	Streptococcus agalactiae RgfB, part of a putative two component signal transduction system, and related proteins; Region: RgfB-like; cd09079
205921006020	putative catalytic site [active]
205921006021	putative metal binding site [ion binding]; other site
205921006022	putative phosphate binding site [ion binding]; other site
205921006023	Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263
205921006024	PTS system, IIBC component; Region: PTS-II-BC-unk1; TIGR02003
205921006025	PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212
205921006026	active site turn [active]
205921006027	phosphorylation site [posttranslational modification]
205921006028	Phosphotransferase system IIA components [Carbohydrate transport and metabolism]; Region: NagE; COG2190
205921006029	HPr interaction site; other site
205921006030	glycerol kinase (GK) interaction site [polypeptide binding]; other site
205921006031	active site
205921006032	phosphorylation site [posttranslational modification]
205921006033	phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966
205921006034	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
205921006035	dimer interface [polypeptide binding]; other site
205921006036	phosphorylation site [posttranslational modification]
205921006037	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
205921006038	ATP binding site [chemical binding]; other site
205921006039	Mg2+ binding site [ion binding]; other site
205921006040	G-X-G motif; other site
205921006041	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
205921006042	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
205921006043	active site
205921006044	phosphorylation site [posttranslational modification]
205921006045	intermolecular recognition site; other site
205921006046	dimerization interface [polypeptide binding]; other site
205921006047	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
205921006048	DNA binding site [nucleotide binding]
205921006049	phosphate transport system regulatory protein PhoU; Region: phoU_full; TIGR02135
205921006050	PhoU domain; Region: PhoU; pfam01895
205921006051	PhoU domain; Region: PhoU; pfam01895
205921006052	phosphate transporter ATP-binding protein; Provisional; Region: PRK14240
205921006053	ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260
205921006054	Walker A/P-loop; other site
205921006055	ATP binding site [chemical binding]; other site
205921006056	Q-loop/lid; other site
205921006057	ABC transporter signature motif; other site
205921006058	Walker B; other site
205921006059	D-loop; other site
205921006060	H-loop/switch region; other site
205921006061	phosphate ABC transporter, permease protein PstA; Region: 3a0107s02c; TIGR00974
205921006062	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
205921006063	dimer interface [polypeptide binding]; other site
205921006064	conserved gate region; other site
205921006065	putative PBP binding loops; other site
205921006066	ABC-ATPase subunit interface; other site
205921006067	ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstC; COG0573
205921006068	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
205921006069	dimer interface [polypeptide binding]; other site
205921006070	conserved gate region; other site
205921006071	putative PBP binding loops; other site
205921006072	ABC-ATPase subunit interface; other site
205921006073	PBP superfamily domain; Region: PBP_like_2; cl17296
205921006074	PBP superfamily domain; Region: PBP_like_2; cl17296
205921006075	Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cd02019
205921006076	AAA domain; Region: AAA_28; pfam13521
205921006077	active site
205921006078	RNA methyltransferase, RsmE family; Region: TIGR00046
205921006079	RNA methyltransferase; Region: Methyltrans_RNA; pfam04452
205921006080	Ribosomal protein L11 methyltransferase (PrmA); Region: PrmA; pfam06325
205921006081	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
205921006082	S-adenosylmethionine binding site [chemical binding]; other site
205921006083	MepB protein; Region: MepB; pfam08877
205921006084	Helix-Turn-Helix DNA binding domain of the transcription regulators TipAL, Mta, and SkgA; Region: HTH_TipAL-Mta; cd01106
205921006085	MerR HTH family regulatory protein; Region: MerR_1; pfam13411
205921006086	DNA binding residues [nucleotide binding]
205921006087	dimer interface [polypeptide binding]; other site
205921006088	TipAS antibiotic-recognition domain; Region: TipAS; pfam07739
205921006089	Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673
205921006090	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
205921006091	Coenzyme A binding pocket [chemical binding]; other site
205921006092	Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_23; cd04682
205921006093	nudix motif; other site
205921006094	ASC-1 homology or ASCH domain, a small beta-barrel domain found in all three kingdoms of life. ASCH resembles the RNA-binding PUA domain and may also interact with RNA. ASCH has been proposed to function as an RNA-binding domain during coactivation; Region: ASCH; cl01020
205921006095	Protein of unknown function (DUF3013); Region: DUF3013; pfam11217
205921006096	putative acetyltransferase; Provisional; Region: PRK03624
205921006097	Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583
205921006098	recombination factor protein RarA; Reviewed; Region: PRK13342
205921006099	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
205921006100	Walker A motif; other site
205921006101	ATP binding site [chemical binding]; other site
205921006102	Walker B motif; other site
205921006103	arginine finger; other site
205921006104	MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002
205921006105	This domain contains a conserved N-terminal (F/Y)RG motif. It is functionally uncharacterised; Region: FRG; smart00901
205921006106	phiLC3 phage and phage-related integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes various bacterial (mainly gram positive) and phage integrases, including those similar to Lactococcus...; Region: INT_phiLC3_C; cd01189
205921006107	Int/Topo IB signature motif; other site
205921006108	Domain of unknown function (DUF3173); Region: DUF3173; pfam11372
205921006109	Replication initiation factor; Region: Rep_trans; pfam02486
205921006110	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
205921006111	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
205921006112	non-specific DNA binding site [nucleotide binding]; other site
205921006113	salt bridge; other site
205921006114	sequence-specific DNA binding site [nucleotide binding]; other site
205921006115	Predicted transcriptional regulator [Transcription]; Region: COG2378
205921006116	HTH domain; Region: HTH_11; pfam08279
205921006117	WYL domain; Region: WYL; pfam13280
205921006118	Type 1 glutamine amidotransferase (GATase1)-like domain found in a subgroup of proteins similar to PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_3; cd03140
205921006119	Putative intracellular protease/amidase [General function prediction only]; Region: ThiJ; COG0693
205921006120	conserved cys residue [active]
205921006121	Protein of unknown function (DUF1310); Region: DUF1310; pfam07006
205921006122	WXG100 family type VII secretion target; Region: WXG100_ESAT6; TIGR03930
205921006123	Protein of unknown function (DUF1310); Region: DUF1310; pfam07006
205921006124	Protein of unknown function (DUF1310); Region: DUF1310; pfam07006
205921006125	Kae1-associated kinase Bud32; Region: arch_bud32; TIGR03724
205921006126	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cd00267
205921006127	Walker A/P-loop; other site
205921006128	ATP binding site [chemical binding]; other site
205921006129	Q-loop/lid; other site
205921006130	ABC transporter signature motif; other site
205921006131	Walker B; other site
205921006132	D-loop; other site
205921006133	Streptomycin adenylyltransferase; Region: Adenyl_transf; pfam04439
205921006134	Protein of unknown function (DUF2785); Region: DUF2785; pfam10978
205921006135	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3293
205921006136	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
205921006137	DDE superfamily endonuclease; Region: DDE_4_2; pfam13613
205921006138	Protein of unknown function (DUF2812); Region: DUF2812; pfam11193
205921006139	Predicted transcriptional regulators [Transcription]; Region: COG1695
205921006140	Transcriptional regulator PadR-like family; Region: PadR; cl17335
205921006141	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
205921006142	Coenzyme A binding pocket [chemical binding]; other site
205921006143	ABC-type transport system involved in multi-copper enzyme maturation, permease component [General function prediction only]; Region: NosY; COG1277
205921006144	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
205921006145	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
205921006146	Walker A/P-loop; other site
205921006147	ATP binding site [chemical binding]; other site
205921006148	Q-loop/lid; other site
205921006149	ABC transporter signature motif; other site
205921006150	Walker B; other site
205921006151	D-loop; other site
205921006152	H-loop/switch region; other site
205921006153	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
205921006154	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
205921006155	non-specific DNA binding site [nucleotide binding]; other site
205921006156	salt bridge; other site
205921006157	sequence-specific DNA binding site [nucleotide binding]; other site
205921006158	PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392
205921006159	active site
205921006160	Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain superfamily; Region: NTP-PPase; cd11523
205921006161	metal binding site [ion binding]; metal-binding site
205921006162	Possible lysine decarboxylase; Region: Lysine_decarbox; cl00695
205921006163	CAAX protease self-immunity; Region: Abi; pfam02517
205921006164	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158
205921006165	active site residue [active]
205921006166	CAMP factor (Cfa); Region: CAMP_factor; pfam07373
205921006167	topology modulation protein; Provisional; Region: PRK07261
205921006168	Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cd02019
205921006169	active site
205921006170	Glycerol dehydrogenase and related enzymes [Energy production and conversion]; Region: GldA; COG0371
205921006171	Glycerol dehydrogenase-like; Region: GlyDH-like2; cd08171
205921006172	putative active site [active]
205921006173	metal binding site [ion binding]; metal-binding site
205921006174	Protein of unknown function (DUF1003); Region: DUF1003; pfam06210
205921006175	bifunctional homocysteine S-methyltransferase/5,10-methylenetetrahydrofolate reductase protein; Reviewed; Region: PRK08645
205921006176	Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; cl14105
205921006177	Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cd00537
205921006178	FAD binding site [chemical binding]; other site
205921006179	5-methyltetrahydropteroyltriglutamate--homocysteine S-methyltransferase; Provisional; Region: PRK05222
205921006180	CIMS - Cobalamine-independent methonine synthase, or MetE, N-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_N_terminal_like; cd03312
205921006181	THF binding site; other site
205921006182	CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311
205921006183	substrate binding site [chemical binding]; other site
205921006184	THF binding site; other site
205921006185	zinc-binding site [ion binding]; other site
205921006186	Predicted membrane protein [Function unknown]; Region: COG4392
205921006187	Predicted branched-chain amino acid permease (azaleucine resistance) [Amino acid transport and metabolism]; Region: AzlC; COG1296
205921006188	YSIRK type signal peptide; Region: YSIRK_signal; pfam04650
205921006189	Peptidase S8 family domain in Streptococcal C5a peptidases; Region: Peptidases_S8_C5a_Peptidase; cd07475
205921006190	putative active site [active]
205921006191	catalytic triad [active]
205921006192	PA_C5a_like: Protease-associated domain containing proteins like Streptococcus pyogenes C5a peptidase. This group contains various PA domain-containing proteins similar to S. pyogenes C5a, including, i) Vpr, a minor extracellular serine protease from...; Region: PA_C5a_like; cd02133
205921006193	putative integrin binding motif; other site
205921006194	PA/protease domain interface [polypeptide binding]; other site
205921006195	Peptidase S8 family domain in Streptococcal C5a peptidases; Region: Peptidases_S8_C5a_Peptidase; cd07475
205921006196	Fn3-like domain (DUF1034); Region: DUF1034; pfam06280
205921006197	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
205921006198	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
205921006199	active site
205921006200	phosphorylation site [posttranslational modification]
205921006201	intermolecular recognition site; other site
205921006202	dimerization interface [polypeptide binding]; other site
205921006203	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
205921006204	DNA binding site [nucleotide binding]
205921006205	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
205921006206	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
205921006207	dimer interface [polypeptide binding]; other site
205921006208	phosphorylation site [posttranslational modification]
205921006209	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
205921006210	ATP binding site [chemical binding]; other site
205921006211	Mg2+ binding site [ion binding]; other site
205921006212	G-X-G motif; other site
205921006213	leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390
205921006214	catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812
205921006215	HIGH motif; other site
205921006216	Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603
205921006217	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
205921006218	active site
205921006219	KMSKS motif; other site
205921006220	Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958
205921006221	tRNA binding surface [nucleotide binding]; other site
205921006222	Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020
205921006223	benzoate transport; Region: 2A0115; TIGR00895
205921006224	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
205921006225	putative substrate translocation pore; other site
205921006226	Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: COG4667
205921006227	Hypothetical patatin similar to yjju protein of Escherichia coli; Region: Pat_hypo_Ecoli_yjju_like; cd07208
205921006228	active site
205921006229	nucleophile elbow; other site
205921006230	transcription antitermination protein NusG; Validated; Region: nusG; PRK05609
205921006231	Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891
205921006232	putative homodimer interface [polypeptide binding]; other site
205921006233	NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091
205921006234	heterodimer interface [polypeptide binding]; other site
205921006235	homodimer interface [polypeptide binding]; other site
205921006236	similar to pathogenicity protein; interuption C-terminus; identified by similarity to GB:AAN00922.1; match to protein family HMM PF00746; match to protein family HMM TIGR01167
205921006237	DDE superfamily endonuclease; Region: DDE_4_2; pfam13613
205921006238	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3293
205921006239	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
205921006240	YSIRK type signal peptide; Region: YSIRK_signal; cl04650
205921006241	Preprotein translocase subunit SecE [Intracellular trafficking and secretion]; Region: SecE; COG0690
205921006242	similar to ribosomal protein L33, type 2; identified by similarity to SP:Q06798; match to protein family HMM PF00471; match to protein family HMM TIGR01023
205921006243	Transglycosylase; Region: Transgly; pfam00912
205921006244	penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074
205921006245	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760
205921006246	Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564
205921006247	Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869
205921006248	active site
205921006249	Predicted membrane protein [Function unknown]; Region: COG4640
205921006250	phosphopentomutase; Provisional; Region: PRK05362
205921006251	Metalloenzyme superfamily; Region: Metalloenzyme; pfam01676
205921006252	2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family; Region: DeoC; cd00959
205921006253	intersubunit interface [polypeptide binding]; other site
205921006254	active site
205921006255	catalytic residue [active]
205921006256	Nucleoside permease [Nucleotide transport and metabolism]; Region: NupC; COG1972
205921006257	Na+ dependent nucleoside transporter N-terminus; Region: Nucleos_tra2_N; pfam01773
205921006258	Nucleoside recognition; Region: Gate; pfam07670
205921006259	Na+ dependent nucleoside transporter C-terminus; Region: Nucleos_tra2_C; pfam07662
205921006260	Uridine phosphorylase [Nucleotide transport and metabolism]; Region: Udp; COG2820
205921006261	Phosphorylase superfamily; Region: PNP_UDP_1; cl00303
205921006262	Transcriptional regulators [Transcription]; Region: PhnF; COG2188
205921006263	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
205921006264	DNA-binding site [nucleotide binding]; DNA binding site
205921006265	chaperonin GroEL; Reviewed; Region: groEL; PRK12849
205921006266	GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344
205921006267	ring oligomerisation interface [polypeptide binding]; other site
205921006268	ATP/Mg binding site [chemical binding]; other site
205921006269	stacking interactions; other site
205921006270	hinge regions; other site
205921006271	Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320
205921006272	oligomerisation interface [polypeptide binding]; other site
205921006273	mobile loop; other site
205921006274	roof hairpin; other site
205921006275	ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: PhnK; COG1101
205921006276	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
205921006277	Walker A/P-loop; other site
205921006278	ATP binding site [chemical binding]; other site
205921006279	Q-loop/lid; other site
205921006280	ABC transporter signature motif; other site
205921006281	Walker B; other site
205921006282	D-loop; other site
205921006283	H-loop/switch region; other site
205921006284	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
205921006285	Transmembrane subunit (TM) of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which are involved in the uptake of branched-chain amino acids (AAs), as well as TMs of transporters involved in the uptake of...; Region: TM_PBP1_branched-chain-AA_like; cd06574
205921006286	TM-ABC transporter signature motif; other site
205921006287	Type I periplasmic ligand-binding domain of uncharacterized ABC-type transport systems that are predicted to be involved in the uptake of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_uncharacterized_transporter; cd06325
205921006288	zinc binding site [ion binding]; other site
205921006289	putative ligand binding site [chemical binding]; other site
205921006290	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
205921006291	haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282
205921006292	active site
205921006293	motif I; other site
205921006294	motif II; other site
205921006295	haloacid dehalogenase-like hydrolase; Region: HAD; cl17202
205921006296	Predicted ring-cleavage extradiol dioxygenase [General function prediction only]; Region: COG2514
205921006297	This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_12; cd07255
205921006298	putative metal binding site [ion binding]; other site
205921006299	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632
205921006300	active site
205921006301	hypothetical protein; Validated; Region: PRK02101
205921006302	4Fe-4S single cluster domain; Region: Fer4_12; pfam13353
205921006303	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
205921006304	FeS/SAM binding site; other site
205921006305	Predicted acetyltransferase [General function prediction only]; Region: COG3981
205921006306	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
205921006307	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
205921006308	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
205921006309	anaerobic ribonucleoside triphosphate reductase; Provisional; Region: PRK09263
205921006310	ATP cone domain; Region: ATP-cone; pfam03477
205921006311	Class III ribonucleotide reductase; Region: RNR_III; cd01675
205921006312	effector binding site; other site
205921006313	active site
205921006314	Zn binding site [ion binding]; other site
205921006315	glycine loop; other site
205921006316	Predicted membrane protein (DUF2079); Region: DUF2079; pfam09852
205921006317	hypothetical protein; Provisional; Region: PRK13678
205921006318	Holliday junction resolvase-like protein; Reviewed; Region: PRK00109
205921006319	hypothetical protein; Provisional; Region: PRK05473
205921006320	Arsenate Reductase (ArsC) family, Spx subfamily; Spx is a unique RNA polymerase (RNAP)-binding protein present in bacilli and some mollicutes. It inhibits transcription by binding to the C-terminal domain of the alpha subunit of RNAP, disrupting complex...; Region: ArsC_Spx; cd03032
205921006321	ArsC family; Region: ArsC; pfam03960
205921006322	putative catalytic residues [active]
205921006323	thiol/disulfide switch; other site
205921006324	recombinase A; Provisional; Region: recA; PRK09354
205921006325	RecA is a  bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response.  RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983
205921006326	hexamer interface [polypeptide binding]; other site
205921006327	Walker A motif; other site
205921006328	ATP binding site [chemical binding]; other site
205921006329	Walker B motif; other site
205921006330	competence damage-inducible protein A; Provisional; Region: PRK00549
205921006331	Competence-damaged protein. CinA is the first gene in the competence- inducible (cin) operon and is thought to be specifically required at some stage in the process of transformation. This domain is closely related to a domain, found in a variety of...; Region: cinA; cd00885
205921006332	putative MPT binding site; other site
205921006333	Uncharacterized protein (competence- and mitomycin-induced) [General function prediction only]; Region: CinA; COG1546
205921006334	Methyladenine glycosylase; Region: Adenine_glyco; pfam03352
205921006335	Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116
205921006336	RuvA N terminal domain; Region: RuvA_N; pfam01330
205921006337	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
205921006338	Major Facilitator Superfamily; Region: MFS_1; pfam07690
205921006339	putative substrate translocation pore; other site
205921006340	DNA mismatch repair protein; Reviewed; Region: mutL; PRK00095
205921006341	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
205921006342	ATP binding site [chemical binding]; other site
205921006343	Mg2+ binding site [ion binding]; other site
205921006344	G-X-G motif; other site
205921006345	MutL_Trans: transducer domain, having a ribosomal S5 domain 2-like fold, conserved in the C-terminal domain of DNA mismatch repair (MutL/MLH1/PMS2) family. This transducer domain is homologous to the second domain of the DNA gyrase B subunit, which is...; Region: MutL_Trans; cd00782
205921006346	ATP binding site [chemical binding]; other site
205921006347	MutL C terminal dimerisation domain; Region: MutL_C; pfam08676
205921006348	Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea.  CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458
205921006349	DNA-binding site [nucleotide binding]; DNA binding site
205921006350	RNA-binding motif; other site
205921006351	DNA mismatch repair protein MutS; Provisional; Region: PRK05399
205921006352	MutS domain I; Region: MutS_I; pfam01624
205921006353	MutS domain II; Region: MutS_II; pfam05188
205921006354	MutS domain III; Region: MutS_III; pfam05192
205921006355	ATP-binding cassette domain of MutS1 homolog; Region: ABC_MutS1; cd03284
205921006356	Walker A/P-loop; other site
205921006357	ATP binding site [chemical binding]; other site
205921006358	Q-loop/lid; other site
205921006359	ABC transporter signature motif; other site
205921006360	Walker B; other site
205921006361	D-loop; other site
205921006362	H-loop/switch region; other site
205921006363	Arginine repressor, DNA binding domain; Region: Arg_repressor; pfam01316
205921006364	arginine repressor; Region: argR_whole; TIGR01529
205921006365	Arginine repressor, C-terminal domain; Region: Arg_repressor_C; pfam02863
205921006366	arginyl-tRNA synthetase; Reviewed; Region: PRK12451
205921006367	Arginyl tRNA synthetase N terminal dom; Region: Arg_tRNA_synt_N; smart01016
205921006368	catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671
205921006369	active site
205921006370	HIGH motif; other site
205921006371	KMSK motif region; other site
205921006372	Anticodon-binding domain of arginyl tRNA synthetases; Region: Anticodon_Ia_Arg; cd07956
205921006373	tRNA binding surface [nucleotide binding]; other site
205921006374	anticodon binding site; other site
205921006375	Enterocin A Immunity; Region: EntA_Immun; pfam08951
205921006376	Uncharacterized conserved protein [Function unknown]; Region: COG1284
205921006377	Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588
205921006378	Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588
205921006379	Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035
205921006380	Uncharacterized conserved protein [Function unknown]; Region: COG1284
205921006381	Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588
205921006382	Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588
205921006383	Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035
205921006384	aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476
205921006385	EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317
205921006386	dimer interface [polypeptide binding]; other site
205921006387	anticodon binding site; other site
205921006388	Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777
205921006389	homodimer interface [polypeptide binding]; other site
205921006390	motif 1; other site
205921006391	active site
205921006392	motif 2; other site
205921006393	GAD domain; Region: GAD; pfam02938
205921006394	Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777
205921006395	motif 3; other site
205921006396	histidyl-tRNA synthetase; Reviewed; Region: hisS; PRK00037
205921006397	Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773
205921006398	dimer interface [polypeptide binding]; other site
205921006399	motif 1; other site
205921006400	active site
205921006401	motif 2; other site
205921006402	HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859
205921006403	anticodon binding site; other site
205921006404	50S ribosomal protein L32; Validated; Region: rpmF; PRK01110
205921006405	50S ribosomal protein L33; Validated; Region: rpmG; PRK00595
205921006406	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
205921006407	Predicted permease, cadmium resistance protein [Inorganic ion transport and metabolism]; Region: CadD; COG4300
205921006408	Cadmium resistance transporter; Region: Cad; pfam03596
205921006409	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
205921006410	putative DNA binding site [nucleotide binding]; other site
205921006411	putative Zn2+ binding site [ion binding]; other site
205921006412	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
205921006413	non-specific DNA binding site [nucleotide binding]; other site
205921006414	salt bridge; other site
205921006415	sequence-specific DNA binding site [nucleotide binding]; other site
205921006416	RNA polymerase sigma factor; Provisional; Region: PRK12519
205921006417	DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674
205921006418	FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580
205921006419	Plasmid replication protein; Region: Rep_2; pfam01719
205921006420	Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582
205921006421	phiLC3 phage and phage-related integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes various bacterial (mainly gram positive) and phage integrases, including those similar to Lactococcus...; Region: INT_phiLC3_C; cd01189
205921006422	Int/Topo IB signature motif; other site
205921006423	Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413
205921006424	Protein of unknown function (DUF2874); Region: DUF2874; pfam11396
205921006425	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
205921006426	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
205921006427	active site
205921006428	phosphorylation site [posttranslational modification]
205921006429	intermolecular recognition site; other site
205921006430	dimerization interface [polypeptide binding]; other site
205921006431	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
205921006432	DNA binding site [nucleotide binding]
205921006433	heavy metal sensor kinase; Region: cztS_silS_copS; TIGR01386
205921006434	HAMP domain; Region: HAMP; pfam00672
205921006435	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
205921006436	dimer interface [polypeptide binding]; other site
205921006437	phosphorylation site [posttranslational modification]
205921006438	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
205921006439	ATP binding site [chemical binding]; other site
205921006440	Mg2+ binding site [ion binding]; other site
205921006441	G-X-G motif; other site
205921006442	Predicted membrane protein [Function unknown]; Region: COG1288
205921006443	C4-dicarboxylate anaerobic carrier; Region: DcuC; pfam03606
205921006444	carbamate kinase; Reviewed; Region: PRK12686
205921006445	AAK_CK: Carbamate kinase (CK) catalyzes both the ATP-phosphorylation of carbamate and carbamoyl phosphate (CP) utilization with the production of ATP from ADP and CP. Both CK (this CD) and nonhomologous CP synthetase synthesize carbamoyl phosphate, an...; Region: AAK_CK; cd04235
205921006446	putative substrate binding site [chemical binding]; other site
205921006447	nucleotide binding site [chemical binding]; other site
205921006448	nucleotide binding site [chemical binding]; other site
205921006449	homodimer interface [polypeptide binding]; other site
205921006450	ornithine carbamoyltransferase; Provisional; Region: PRK04284
205921006451	Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729
205921006452	Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185
205921006453	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
205921006454	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
205921006455	ATP binding site [chemical binding]; other site
205921006456	Mg2+ binding site [ion binding]; other site
205921006457	G-X-G motif; other site
205921006458	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
205921006459	Response regulator receiver domain; Region: Response_reg; pfam00072
205921006460	active site
205921006461	phosphorylation site [posttranslational modification]
205921006462	intermolecular recognition site; other site
205921006463	dimerization interface [polypeptide binding]; other site
205921006464	YcbB domain; Region: YcbB; pfam08664
205921006465	ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126
205921006466	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
205921006467	Walker A/P-loop; other site
205921006468	ATP binding site [chemical binding]; other site
205921006469	Q-loop/lid; other site
205921006470	ABC transporter signature motif; other site
205921006471	Walker B; other site
205921006472	D-loop; other site
205921006473	H-loop/switch region; other site
205921006474	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
205921006475	dimer interface [polypeptide binding]; other site
205921006476	conserved gate region; other site
205921006477	ABC-ATPase subunit interface; other site
205921006478	Periplasmic glycine betaine/choline-binding (lipo)protein of an ABC-type transport system (osmoprotectant binding protein) [Cell envelope biogenesis, outer membrane]; Region: OpuBC; COG1732
205921006479	Predicted integral membrane protein [Function unknown]; Region: COG0392
205921006480	Uncharacterized conserved protein [Function unknown]; Region: COG2898
205921006481	Uncharacterized conserved protein (DUF2156); Region: DUF2156; pfam09924
205921006482	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
205921006483	Protein of unknown function (DUF1304); Region: DUF1304; pfam06993
205921006484	YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061
205921006485	Predicted membrane protein [Function unknown]; Region: COG1511
205921006486	X-X-X-Leu-X-X-Gly heptad repeats; Region: xxxLxxG_by_4; TIGR03057
205921006487	YhgE/Pip C-terminal domain; Region: pip_yhgE_Cterm; TIGR03062
205921006488	probable dihydroxyacetone kinase regulator; Region: DHAK_reg; TIGR02366
205921006489	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
205921006490	Domain of unknown function (DUF4298); Region: DUF4298; pfam14131
205921006491	Protein of unknown function (DUF4065); Region: DUF4065; pfam13274
205921006492	Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170
205921006493	phage transcriptional regulator, ArpU family; Region: phage_arpU; TIGR01637
205921006494	Protein of unknown function (DUF1492); Region: DUF1492; pfam07374
205921006495	D5 N terminal like; Region: D5_N; smart00885
205921006496	phage/plasmid primase, P4 family, C-terminal domain; Region: primase_Cterm; TIGR01613
205921006497	Primase C terminal 1 (PriCT-1); Region: PriCT_1; smart00942
205921006498	4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Reviewed; Region: ispG; PRK00366
205921006499	Ribbon-helix-helix protein, copG family; Region: RHH_1; pfam01402
205921006500	Uncharacterized phage-encoded protein [Function unknown]; Region: COG3646
205921006501	BRO family, N-terminal domain; Region: Bro-N; smart01040
205921006502	Prophage antirepressor [Transcription]; Region: COG3617
205921006503	BRO family, N-terminal domain; Region: Bro-N; smart01040
205921006504	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
205921006505	sequence-specific DNA binding site [nucleotide binding]; other site
205921006506	salt bridge; other site
205921006507	Protein of unknown function (DUF3644); Region: DUF3644; pfam12358
205921006508	Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582
205921006509	phiLC3 phage and phage-related integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes various bacterial (mainly gram positive) and phage integrases, including those similar to Lactococcus...; Region: INT_phiLC3_C; cd01189
205921006510	Int/Topo IB signature motif; other site
205921006511	30S ribosomal protein S4; Validated; Region: rpsD; PRK05327
205921006512	Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163
205921006513	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
205921006514	RNA binding surface [nucleotide binding]; other site
205921006515	Uncharacterized protein conserved in bacteria [Function unknown]; Region: Veg; COG4466
205921006516	replicative DNA helicase; Provisional; Region: PRK05748
205921006517	DnaB-like helicase N terminal domain; Region: DnaB; pfam00772
205921006518	DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the  chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984
205921006519	Walker A motif; other site
205921006520	ATP binding site [chemical binding]; other site
205921006521	Walker B motif; other site
205921006522	DNA binding loops [nucleotide binding]
205921006523	50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137
205921006524	Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281
205921006525	Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948
205921006526	Predicted signaling protein consisting of a modified GGDEF domain and a DHH domain [Signal transduction mechanisms]; Region: COG3887
205921006527	DHH family; Region: DHH; pfam01368
205921006528	DHHA1 domain; Region: DHHA1; pfam02272
205921006529	tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA; Validated; Region: PRK05192
205921006530	NAD(FAD)-utilizing enzyme possibly involved in translation [Translation, ribosomal structure and biogenesis]; Region: Gid; COG1206
205921006531	GidA associated domain 3; Region: GIDA_assoc_3; pfam13932
205921006532	Multiple antibiotic transporter [Intracellular trafficking and secretion]; Region: MarC; COG2095
205921006533	Predicted tRNA(5-methylaminomethyl-2-thiouridylate) methyltransferase, contains the PP-loop ATPase domain [Translation, ribosomal structure and biogenesis]; Region: TrmU; COG0482
205921006534	tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998
205921006535	L-serine dehydratase, iron-sulfur-dependent, beta subunit; Region: sda_beta; TIGR00719
205921006536	Serine dehydratase beta chain; Region: SDH_beta; pfam03315
205921006537	C-terminal ACT domain of the L-serine dehydratase (LSD), iron-sulfur-dependent, beta subunit; Region: ACT_LSD; cd04903
205921006538	putative L-serine binding site [chemical binding]; other site
205921006539	Serine dehydratase alpha chain; Region: SDH_alpha; cl12120
205921006540	L-serine deaminase [Amino acid transport and metabolism]; Region: SdaA; COG1760
205921006541	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
205921006542	N-acetyl-D-glucosamine binding site [chemical binding]; other site
205921006543	catalytic residue [active]
205921006544	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
205921006545	ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619
205921006546	cobalt transporter ATP-binding subunit; Provisional; Region: cbiO; PRK13649
205921006547	First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225
205921006548	Walker A/P-loop; other site
205921006549	ATP binding site [chemical binding]; other site
205921006550	Q-loop/lid; other site
205921006551	ABC transporter signature motif; other site
205921006552	Walker B; other site
205921006553	D-loop; other site
205921006554	H-loop/switch region; other site
205921006555	cobalt transporter ATP-binding subunit; Provisional; Region: cbiO; PRK13650
205921006556	First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225
205921006557	Walker A/P-loop; other site
205921006558	ATP binding site [chemical binding]; other site
205921006559	Q-loop/lid; other site
205921006560	ABC transporter signature motif; other site
205921006561	Walker B; other site
205921006562	D-loop; other site
205921006563	H-loop/switch region; other site
205921006564	CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453
205921006565	Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612
205921006566	Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675
205921006567	Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193
205921006568	Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612
205921006569	Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193
205921006570	S4 domain protein YaaA; Region: YaaA_near_RecF; TIGR02988
205921006571	recombination protein F; Reviewed; Region: recF; PRK00064
205921006572	ATP-binding cassette domain of RecF; Region: ABC_RecF; cd03242
205921006573	Walker A/P-loop; other site
205921006574	ATP binding site [chemical binding]; other site
205921006575	Q-loop/lid; other site
205921006576	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
205921006577	ABC transporter signature motif; other site
205921006578	Walker B; other site
205921006579	D-loop; other site
205921006580	H-loop/switch region; other site
205921006581	Sugar transport protein; Region: Sugar_transport; pfam06800
205921006582	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
205921006583	non-specific DNA binding site [nucleotide binding]; other site
205921006584	salt bridge; other site
205921006585	sequence-specific DNA binding site [nucleotide binding]; other site
205921006586	inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567
205921006587	TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186
205921006588	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein.  IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a...; Region: CBS_pair_IMPDH; cd04601
205921006589	IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381
205921006590	active site
205921006591	Arginine repressor [Transcription]; Region: ArgR; COG1438
205921006592	Arginine repressor, DNA binding domain; Region: Arg_repressor; pfam01316
205921006593	Arginine repressor, C-terminal domain; Region: Arg_repressor_C; pfam02863
205921006594	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
205921006595	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
205921006596	ligand binding site [chemical binding]; other site
205921006597	flexible hinge region; other site
205921006598	helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092
205921006599	non-specific DNA interactions [nucleotide binding]; other site
205921006600	DNA binding site [nucleotide binding]
205921006601	sequence specific DNA binding site [nucleotide binding]; other site
205921006602	putative cAMP binding site [chemical binding]; other site
205921006603	Solo B3/4 domain (OB-fold DNA/RNA-binding) of Phe-aaRS-beta [General function prediction only]; Region: COG3382
205921006604	B3/4 domain; Region: B3_4; pfam03483
205921006605	arginine deiminase; Provisional; Region: PRK01388
205921006606	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
205921006607	Coenzyme A binding pocket [chemical binding]; other site
205921006608	ornithine carbamoyltransferase; Validated; Region: PRK02102
205921006609	Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729
205921006610	Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185
205921006611	arginine-ornithine antiporter; Region: arg_ornith_anti; TIGR03810
205921006612	carbamate kinase; Reviewed; Region: PRK12686
205921006613	AAK_CK: Carbamate kinase (CK) catalyzes both the ATP-phosphorylation of carbamate and carbamoyl phosphate (CP) utilization with the production of ATP from ADP and CP. Both CK (this CD) and nonhomologous CP synthetase synthesize carbamoyl phosphate, an...; Region: AAK_CK; cd04235
205921006614	putative substrate binding site [chemical binding]; other site
205921006615	nucleotide binding site [chemical binding]; other site
205921006616	nucleotide binding site [chemical binding]; other site
205921006617	homodimer interface [polypeptide binding]; other site
205921006618	tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282
205921006619	catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806
205921006620	active site
205921006621	HIGH motif; other site
205921006622	dimer interface [polypeptide binding]; other site
205921006623	KMSKS motif; other site
205921006624	Protein of unknown function (DUF1275); Region: DUF1275; pfam06912
205921006625	Uncharacterized conserved protein [Function unknown]; Region: COG1284
205921006626	Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035
205921006627	ABC transporter ATP-binding protein; Provisional; Region: PRK15064
205921006628	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
205921006629	Walker A/P-loop; other site
205921006630	ATP binding site [chemical binding]; other site
205921006631	Q-loop/lid; other site
205921006632	ABC transporter signature motif; other site
205921006633	Walker B; other site
205921006634	D-loop; other site
205921006635	H-loop/switch region; other site
205921006636	ABC transporter; Region: ABC_tran_2; pfam12848
205921006637	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
205921006638	Bacterial membrane protein YfhO; Region: YfhO; pfam09586
205921006639	rRNA large subunit methyltransferase; Provisional; Region: PRK00103
205921006640	periplasmic serine pepetdase DegS; Region: protease_degS; TIGR02038
205921006641	Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365
205921006642	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
205921006643	protein binding site [polypeptide binding]; other site
205921006644	ParB/RepB/Spo0J family partition protein; Region: parB_part; TIGR00180
205921006645	ParB-like nuclease domain; Region: ParBc; pfam02195
205921006646	Sugar-specific transcriptional regulator TrmB; Region: TrmB; cl17775