-- dump date 20140620_081310 -- class Genbank::misc_feature -- table misc_feature_note -- id note 211110000001 chromosomal replication initiation protein; Reviewed; Region: dnaA; PRK00149 211110000002 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 211110000003 Walker A motif; other site 211110000004 ATP binding site [chemical binding]; other site 211110000005 Walker B motif; other site 211110000006 arginine finger; other site 211110000007 C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571 211110000008 DnaA box-binding interface [nucleotide binding]; other site 211110000009 DNA polymerase III subunit beta; Validated; Region: PRK05643 211110000010 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140 211110000011 putative DNA binding surface [nucleotide binding]; other site 211110000012 dimer interface [polypeptide binding]; other site 211110000013 beta-clamp/clamp loader binding surface; other site 211110000014 beta-clamp/translesion DNA polymerase binding surface; other site 211110000015 Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase [Lipid metabolism / General function prediction only]; Region: LCB5; COG1597 211110000016 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 211110000017 Bacterial protein of unknown function (DUF951); Region: DUF951; pfam06107 211110000018 GTP-binding protein YchF; Reviewed; Region: PRK09601 211110000019 YchF GTPase; Region: YchF; cd01900 211110000020 G1 box; other site 211110000021 GTP/Mg2+ binding site [chemical binding]; other site 211110000022 Switch I region; other site 211110000023 G2 box; other site 211110000024 Switch II region; other site 211110000025 G3 box; other site 211110000026 G4 box; other site 211110000027 G5 box; other site 211110000028 TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867 211110000029 Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462 211110000030 putative active site [active] 211110000031 catalytic residue [active] 211110000032 Transcription-repair coupling factor (superfamily II helicase) [DNA replication, recombination, and repair / Transcription]; Region: Mfd; COG1197 211110000033 CarD-like/TRCF domain; Region: CarD_TRCF; smart01058 211110000034 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 211110000035 ATP binding site [chemical binding]; other site 211110000036 putative Mg++ binding site [ion binding]; other site 211110000037 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 211110000038 nucleotide binding region [chemical binding]; other site 211110000039 ATP-binding site [chemical binding]; other site 211110000040 This domain is found in proteins necessary for strand-specific repair in DNA such as TRCF in Escherichia coli; Region: TRCF; smart00982 211110000041 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 211110000042 RNA binding surface [nucleotide binding]; other site 211110000043 Septum formation initiator [Cell division and chromosome partitioning]; Region: COG2919 211110000044 Septum formation initiator; Region: DivIC; pfam04977 211110000045 Beta-lactamase enzyme family; Region: Beta-lactamase2; pfam13354 211110000046 tRNA(Ile)-lysidine synthase MesJ [Cell cycle control, cell division, chromosome partitioning]; Region: MesJ; COG0037 211110000047 N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992 211110000048 Ligand Binding Site [chemical binding]; other site 211110000049 TilS substrate C-terminal domain; Region: TilS_C; smart00977 211110000050 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 211110000051 active site 211110000052 ATP-dependent Zn proteases [Posttranslational modification, protein turnover, chaperones]; Region: HflB; COG0465 211110000053 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 211110000054 Walker A motif; other site 211110000055 ATP binding site [chemical binding]; other site 211110000056 Walker B motif; other site 211110000057 arginine finger; other site 211110000058 Peptidase family M41; Region: Peptidase_M41; pfam01434 211110000059 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3883 211110000060 Enolase-superfamily, characterized by the presence of an enolate anion intermediate which is generated by abstraction of the alpha-proton of the carboxylate substrate by an active site residue and is stabilized by coordination to the essential Mg2+ ion; Region: enolase_like; cl17188 211110000061 Surface antigen [General function prediction only]; Region: COG3942 211110000062 CHAP domain; Region: CHAP; pfam05257 211110000063 ribose-phosphate pyrophosphokinase; Provisional; Region: PRK02269 211110000064 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 211110000065 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 211110000066 active site 211110000067 aromatic amino acid aminotransferase; Validated; Region: PRK07309 211110000068 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 211110000069 pyridoxal 5'-phosphate binding site [chemical binding]; other site 211110000070 homodimer interface [polypeptide binding]; other site 211110000071 catalytic residue [active] 211110000072 Recombination protein O N terminal; Region: RecO_N; pfam11967 211110000073 DNA repair protein RecO; Region: reco; TIGR00613 211110000074 Recombination protein O C terminal; Region: RecO_C; pfam02565 211110000075 CAAX protease self-immunity; Region: Abi; pfam02517 211110000076 putative phosphate acyltransferase; Provisional; Region: PRK05331 211110000077 acyl carrier protein; Provisional; Region: PRK12449 211110000078 phosphoribosylaminoimidazole-succinocarboxamide synthase; Reviewed; Region: PRK09362 211110000079 bacterial and archaeal 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_PurC; cd01415 211110000080 ATP binding site [chemical binding]; other site 211110000081 active site 211110000082 substrate binding site [chemical binding]; other site 211110000083 phosphoribosylformylglycinamidine synthase, clade II; Region: FGAM-synthase; TIGR01857 211110000084 AIR (aminoimidazole ribonucleotide) synthase related protein. This family includes Hydrogen expression/formation protein HypE, AIR synthases, FGAM (formylglycinamidine ribonucleotide) synthase and Selenophosphate synthetase (SelD). The N-terminal domain...; Region: PurM-like; cl10019 211110000085 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203 211110000086 dimerization interface [polypeptide binding]; other site 211110000087 ATP binding site [chemical binding]; other site 211110000088 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat2; cd02204 211110000089 dimerization interface [polypeptide binding]; other site 211110000090 ATP binding site [chemical binding]; other site 211110000091 Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740 211110000092 putative active site [active] 211110000093 catalytic triad [active] 211110000094 amidophosphoribosyltransferase; Provisional; Region: PRK07272 211110000095 Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715 211110000096 active site 211110000097 tetramer interface [polypeptide binding]; other site 211110000098 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 211110000099 active site 211110000100 phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385 211110000101 PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196 211110000102 dimerization interface [polypeptide binding]; other site 211110000103 putative ATP binding site [chemical binding]; other site 211110000104 phosphoribosylglycinamide formyltransferase; Reviewed; Region: purN; PRK05647 211110000105 Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645 211110000106 active site 211110000107 substrate binding site [chemical binding]; other site 211110000108 cosubstrate binding site; other site 211110000109 catalytic site [active] 211110000110 GNAT acetyltransferase; Region: GNAT_acetyltran; pfam12746 211110000111 Predicted acetyltransferase [General function prediction only]; Region: COG3393 211110000112 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881 211110000113 Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal ATIC formylase domain that formylates...; Region: IMPCH; cd01421 211110000114 purine monophosphate binding site [chemical binding]; other site 211110000115 dimer interface [polypeptide binding]; other site 211110000116 putative catalytic residues [active] 211110000117 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; smart00798 211110000118 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; cl03362 211110000119 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 211110000120 Peptidase family M23; Region: Peptidase_M23; pfam01551 211110000121 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 211110000122 N-acetylmannosamine-6-phosphate epimerase (NanE) converts N-acetylmannosamine-6-phosphate to N-acetylglucosamine-6-phosphate. This reaction is part of the pathway that allows the usage of sialic acid as a carbohydrate source. Sialic acids are a family of...; Region: NanE; cd04729 211110000123 N-acetylmannosamine-6-phosphate 2-epimerase; Provisional; Region: PRK01130 211110000124 putative active site cavity [active] 211110000125 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 211110000126 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 211110000127 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 211110000128 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 211110000129 dimer interface [polypeptide binding]; other site 211110000130 ABC-ATPase subunit interface; other site 211110000131 putative PBP binding loops; other site 211110000132 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 211110000133 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 211110000134 dimer interface [polypeptide binding]; other site 211110000135 conserved gate region; other site 211110000136 putative PBP binding loops; other site 211110000137 ABC-ATPase subunit interface; other site 211110000138 Domain of unknown function (DUF386); Region: DUF386; cl01047 211110000139 Protein of unknown function, DUF624; Region: DUF624; pfam04854 211110000140 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 211110000141 Class I aldolases; Region: Aldolase_Class_I; cl17187 211110000142 catalytic residue [active] 211110000143 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 211110000144 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 211110000145 nucleotide binding site [chemical binding]; other site 211110000146 Acetyl xylan esterase (AXE1); Region: AXE1; pfam05448 211110000147 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 211110000148 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 211110000149 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 211110000150 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 211110000151 putative active site [active] 211110000152 phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885 211110000153 Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844 211110000154 Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Region: GARS_A; pfam01071 211110000155 Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843 211110000156 Phosphoribosylcarboxyaminoimidazole (NCAIR) mutase [Nucleotide transport and metabolism]; Region: PurE; COG0041 211110000157 phosphoribosylaminoimidazole carboxylase ATPase subunit; Reviewed; Region: PRK06019 211110000158 ATP-grasp domain; Region: ATP-grasp; pfam02222 211110000159 adenylosuccinate lyase; Provisional; Region: PRK07492 211110000160 Adenylsuccinate lyase (ASL)_subgroup 1; Region: Adenylsuccinate_lyase_1; cd01360 211110000161 tetramer interface [polypeptide binding]; other site 211110000162 active site 211110000163 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 211110000164 non-specific DNA binding site [nucleotide binding]; other site 211110000165 salt bridge; other site 211110000166 sequence-specific DNA binding site [nucleotide binding]; other site 211110000167 Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080 211110000168 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 211110000169 Walker A motif; other site 211110000170 ATP binding site [chemical binding]; other site 211110000171 Walker B motif; other site 211110000172 arginine finger; other site 211110000173 Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491 211110000174 Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394 211110000175 Low molecular weight phosphatase family; Region: LMWPc; cd00115 211110000176 active site 211110000177 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4642 211110000178 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 211110000179 glucans biosynthesis protein; Provisional; Region: opgC; PRK03854 211110000180 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053 211110000181 active site 211110000182 catalytic triad [active] 211110000183 oxyanion hole [active] 211110000184 bifunctional acetaldehyde-CoA/alcohol dehydrogenase; Provisional; Region: PRK13805 211110000185 Coenzyme A acylating aldehyde dehydrogenase (ACDH), ALDH family 20-like; Region: ALDH_F20_ACDH; cd07122 211110000186 putative catalytic cysteine [active] 211110000187 C-terminal alcohol dehydrogenase domain of the acetaldehyde dehydrogenase-alcohol dehydrogenase bifunctional two-domain protein (AAD); Region: AAD_C; cd08178 211110000188 putative active site [active] 211110000189 metal binding site [ion binding]; metal-binding site 211110000190 ethanol-active dehydrogenase/acetaldehyde-active reductase; Provisional; Region: PRK09422 211110000191 Cinnamyl alcohol dehydrogenases (CAD); Region: CAD3; cd08297 211110000192 NAD binding site [chemical binding]; other site 211110000193 substrate binding site [chemical binding]; other site 211110000194 catalytic Zn binding site [ion binding]; other site 211110000195 tetramer interface [polypeptide binding]; other site 211110000196 structural Zn binding site [ion binding]; other site 211110000197 Threonine synthase catalyzes the final step of threonine biosynthesis. The conversion of O-phosphohomoserine into threonine and inorganic phosphate is pyridoxal 5'-phosphate dependent. The Thr-synth_1 CD includes members from higher plants; Region: Thr-synth_2; cd01560 211110000198 Threonine synthase [Amino acid transport and metabolism]; Region: ThrC; COG0498 211110000199 pyridoxal 5'-phosphate binding site [chemical binding]; other site 211110000200 catalytic residue [active] 211110000201 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 211110000202 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Thermotoga marina NorM; Region: MATE_NorM_like; cd13137 211110000203 30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596 211110000204 50S ribosomal protein L3; Validated; Region: rplC; PRK00001 211110000205 50S ribosomal protein L4; Provisional; Region: rplD; PRK05319 211110000206 50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738 211110000207 50S ribosomal protein L2; Validated; Region: rplB; PRK09374 211110000208 Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181 211110000209 Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947 211110000210 30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357 211110000211 Ribosomal protein L22/L17e. L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit. It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336 211110000212 putative translocon binding site; other site 211110000213 protein-rRNA interface [nucleotide binding]; other site 211110000214 30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310 211110000215 K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3 is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel. The KH...; Region: 30S_S3_KH; cd02412 211110000216 G-X-X-G motif; other site 211110000217 Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189 211110000218 Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433 211110000219 23S rRNA interface [nucleotide binding]; other site 211110000220 5S rRNA interface [nucleotide binding]; other site 211110000221 putative antibiotic binding site [chemical binding]; other site 211110000222 L25 interface [polypeptide binding]; other site 211110000223 L27 interface [polypeptide binding]; other site 211110000224 Ribosomal L29 protein/HIP. L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals. L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427 211110000225 23S rRNA interface [nucleotide binding]; other site 211110000226 putative translocon interaction site; other site 211110000227 signal recognition particle (SRP54) interaction site; other site 211110000228 L23 interface [polypeptide binding]; other site 211110000229 trigger factor interaction site; other site 211110000230 30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610 211110000231 50S ribosomal protein L14; Validated; Region: rplN; PRK05483 211110000232 50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004 211110000233 KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089 211110000234 RNA binding site [nucleotide binding]; other site 211110000235 50S ribosomal protein L5; Validated; Region: rplE; PRK00010 211110000236 Ribosomal protein L5; Region: Ribosomal_L5; pfam00281 211110000237 ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673 211110000238 30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08061 211110000239 30S ribosomal protein S8; Validated; Region: rpsH; PRK00136 211110000240 50S ribosomal protein L6; Validated; Region: rplF; PRK05498 211110000241 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 211110000242 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 211110000243 Ribosomal L18/L5e: L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432 211110000244 5S rRNA interface [nucleotide binding]; other site 211110000245 L27 interface [polypeptide binding]; other site 211110000246 23S rRNA interface [nucleotide binding]; other site 211110000247 L5 interface [polypeptide binding]; other site 211110000248 30S ribosomal protein S5; Validated; Region: rpsE; PRK00550 211110000249 Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333 211110000250 Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719 211110000251 Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins that...; Region: Ribosomal_L30; cd01658 211110000252 23S rRNA binding site [nucleotide binding]; other site 211110000253 50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592 211110000254 preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204 211110000255 SecY translocase; Region: SecY; pfam00344 211110000256 adenylate kinase; Reviewed; Region: adk; PRK00279 211110000257 Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428 211110000258 AMP-binding site [chemical binding]; other site 211110000259 ATP-AMP (Ap5A)-binding site [chemical binding]; other site 211110000260 S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451 211110000261 rRNA binding site [nucleotide binding]; other site 211110000262 predicted 30S ribosome binding site; other site 211110000263 Ribosomal protein L36; Region: Ribosomal_L36; pfam00444 211110000264 Ribosomal protein S13 [Translation, ribosomal structure and biogenesis]; Region: RpsM; COG0099 211110000265 30S ribosomal protein S13; Region: bact_S13; TIGR03631 211110000266 30S ribosomal protein S11; Validated; Region: PRK05309 211110000267 DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182 211110000268 N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928 211110000269 alphaNTD homodimer interface [polypeptide binding]; other site 211110000270 alphaNTD - beta interaction site [polypeptide binding]; other site 211110000271 alphaNTD - beta' interaction site [polypeptide binding]; other site 211110000272 Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118 211110000273 50S ribosomal protein L17; Validated; Region: rplQ; PRK05591 211110000274 Bacterial protein of unknown function (DUF925); Region: DUF925; pfam06042 211110000275 Protein of unknown function (DUF2992); Region: DUF2992; pfam11208 211110000276 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 211110000277 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 211110000278 catalytic core [active] 211110000279 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 211110000280 D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: VanY; COG1876 211110000281 D-alanyl-D-alanine carboxypeptidase; Region: VanY; pfam02557 211110000282 Mannosyl-glycoprotein endo-beta-N-acetylglucosaminidase; Region: Glucosaminidase; cl17361 211110000283 heat-inducible transcription repressor; Provisional; Region: hrcA; PRK00082 211110000284 GrpE; Region: GrpE; pfam01025 211110000285 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446 211110000286 dimer interface [polypeptide binding]; other site 211110000287 hsp70 (ATPase domain) interactions [polypeptide binding]; other site 211110000288 molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290 211110000289 Nucleotide-binding domain of human HSPA9 and similar proteins; Region: HSPA9-Ssq1-like_NBD; cd10234 211110000290 nucleotide binding site [chemical binding]; other site 211110000291 NEF interaction site [polypeptide binding]; other site 211110000292 SBD interface [polypeptide binding]; other site 211110000293 chaperone protein DnaJ; Provisional; Region: PRK14276 211110000294 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 211110000295 HSP70 interaction site [polypeptide binding]; other site 211110000296 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cl03262 211110000297 substrate binding site [polypeptide binding]; other site 211110000298 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 211110000299 Zn binding sites [ion binding]; other site 211110000300 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 211110000301 dimer interface [polypeptide binding]; other site 211110000302 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 211110000303 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 211110000304 DNA-binding site [nucleotide binding]; DNA binding site 211110000305 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 211110000306 pyridoxal 5'-phosphate binding site [chemical binding]; other site 211110000307 homodimer interface [polypeptide binding]; other site 211110000308 catalytic residue [active] 211110000309 tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021 211110000310 Eukaryotic and bacterial pseudouridine synthases similar to E. coli TruA; Region: PseudoU_synth_EcTruA; cd02570 211110000311 dimerization interface 3.5A [polypeptide binding]; other site 211110000312 active site 211110000313 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 211110000314 dimer interface [polypeptide binding]; other site 211110000315 substrate binding site [chemical binding]; other site 211110000316 ATP binding site [chemical binding]; other site 211110000317 ECF-type riboflavin transporter, S component; Region: ECF-ribofla_trS; pfam07155 211110000318 hypothetical protein; Provisional; Region: PRK13690 211110000319 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 211110000320 Mechanosensitive ion channel; Region: MS_channel; pfam00924 211110000321 trigger factor; Provisional; Region: tig; PRK01490 211110000322 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 211110000323 Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698 211110000324 DNA-directed RNA polymerase delta subunit; Region: RNA_pol_delta; pfam05066 211110000325 CTP synthetase; Validated; Region: pyrG; PRK05380 211110000326 CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113 211110000327 Catalytic site [active] 211110000328 active site 211110000329 UTP binding site [chemical binding]; other site 211110000330 Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746 211110000331 active site 211110000332 putative oxyanion hole; other site 211110000333 catalytic triad [active] 211110000334 Hydrolases of the alpha/beta superfamily [General function prediction only]; Region: COG1073 211110000335 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 211110000336 trimer interface [polypeptide binding]; other site 211110000337 active site 211110000338 DNA repair protein RadA; Provisional; Region: PRK11823 211110000339 Sms (bacterial radA) DNA repair protein. This protein is not related to archael radA any more than is to other RecA-like NTPases. Sms has a role in recombination and recombinational repair and is responsible for the stabilization or processing of...; Region: Sms; cd01121 211110000340 Walker A motif/ATP binding site; other site 211110000341 ATP binding site [chemical binding]; other site 211110000342 Walker B motif; other site 211110000343 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 211110000344 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeD; cd03379 211110000345 active site clefts [active] 211110000346 zinc binding site [ion binding]; other site 211110000347 dimer interface [polypeptide binding]; other site 211110000348 pyridine nucleotide-disulfide oxidoreductase; Provisional; Region: PRK07251 211110000349 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 211110000350 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 211110000351 glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406 211110000352 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 211110000353 active site 211110000354 HIGH motif; other site 211110000355 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 211110000356 active site 211110000357 KMSKS motif; other site 211110000358 Periplasmic sugar-binding domain of the thermophilic Thermoanaerobacter tengcongensis ribose binding protein (ttRBP) and its mesophilic homologs; Region: PBP1_ribose_binding; cd06323 211110000359 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 211110000360 ligand binding site [chemical binding]; other site 211110000361 dimerization interface [polypeptide binding]; other site 211110000362 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 211110000363 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 211110000364 TM-ABC transporter signature motif; other site 211110000365 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 211110000366 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 211110000367 Walker A/P-loop; other site 211110000368 ATP binding site [chemical binding]; other site 211110000369 Q-loop/lid; other site 211110000370 ABC transporter signature motif; other site 211110000371 Walker B; other site 211110000372 D-loop; other site 211110000373 H-loop/switch region; other site 211110000374 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 211110000375 D-ribose pyranase; Provisional; Region: PRK11797 211110000376 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 211110000377 Ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This reaction is the first step in the ribose metabolism. It traps ribose within the cell after uptake and also prepares the sugar for use in the synthesis of nucleotides...; Region: ribokinase; cd01174 211110000378 substrate binding site [chemical binding]; other site 211110000379 dimer interface [polypeptide binding]; other site 211110000380 ATP binding site [chemical binding]; other site 211110000381 Transcriptional regulators [Transcription]; Region: PurR; COG1609 211110000382 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 211110000383 DNA binding site [nucleotide binding] 211110000384 domain linker motif; other site 211110000385 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 211110000386 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 211110000387 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 211110000388 FtsX-like permease family; Region: FtsX; pfam02687 211110000389 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 211110000390 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 211110000391 Walker A/P-loop; other site 211110000392 ATP binding site [chemical binding]; other site 211110000393 Q-loop/lid; other site 211110000394 ABC transporter signature motif; other site 211110000395 Walker B; other site 211110000396 D-loop; other site 211110000397 H-loop/switch region; other site 211110000398 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 211110000399 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 211110000400 active site 211110000401 phosphorylation site [posttranslational modification] 211110000402 intermolecular recognition site; other site 211110000403 dimerization interface [polypeptide binding]; other site 211110000404 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 211110000405 DNA binding site [nucleotide binding] 211110000406 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 211110000407 HAMP domain; Region: HAMP; pfam00672 211110000408 dimerization interface [polypeptide binding]; other site 211110000409 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 211110000410 dimer interface [polypeptide binding]; other site 211110000411 phosphorylation site [posttranslational modification] 211110000412 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 211110000413 ATP binding site [chemical binding]; other site 211110000414 Mg2+ binding site [ion binding]; other site 211110000415 G-X-G motif; other site 211110000416 argininosuccinate synthase; Provisional; Region: PRK13820 211110000417 Argininosuccinate synthase. The Argininosuccinate synthase is a urea cycle enzyme that catalyzes the penultimate step in arginine biosynthesis: the ATP-dependent ligation of citrulline to aspartate to form argininosuccinate, AMP and pyrophosphate . In...; Region: Argininosuccinate_Synthase; cd01999 211110000418 ANP binding site [chemical binding]; other site 211110000419 Substrate Binding Site II [chemical binding]; other site 211110000420 Substrate Binding Site I [chemical binding]; other site 211110000421 argininosuccinate lyase; Provisional; Region: PRK00855 211110000422 Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359 211110000423 active sites [active] 211110000424 tetramer interface [polypeptide binding]; other site 211110000425 fructose-bisphosphate aldolase; Provisional; Region: PRK09197 211110000426 Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947 211110000427 intersubunit interface [polypeptide binding]; other site 211110000428 active site 211110000429 zinc binding site [ion binding]; other site 211110000430 Na+ binding site [ion binding]; other site 211110000431 L-2-hydroxyisocapronate dehydrogenases and some bacterial L-lactate dehydrogenases; Region: HicDH_like; cd05291 211110000432 tetramer (dimer of dimers) interface [polypeptide binding]; other site 211110000433 L-lactate dehydrogenase; Region: L-LDH-NAD; TIGR01771 211110000434 NAD binding site [chemical binding]; other site 211110000435 dimer interface [polypeptide binding]; other site 211110000436 substrate binding site [chemical binding]; other site 211110000437 50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359 211110000438 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1302 211110000439 DAK2 domain fusion protein YloV; Region: YloV; TIGR03599 211110000440 DAK2 domain; Region: Dak2; pfam02734 211110000441 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 211110000442 A subgroup of the band 7 domain of flotillin (reggie) like proteins. This subgroup contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin. Many of these band 7 domain-containing proteins are lipid raft-associated. Individual...; Region: Band_7_4; cd03407 211110000443 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 211110000444 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 211110000445 Walker A/P-loop; other site 211110000446 ATP binding site [chemical binding]; other site 211110000447 Q-loop/lid; other site 211110000448 ABC transporter signature motif; other site 211110000449 Walker B; other site 211110000450 D-loop; other site 211110000451 H-loop/switch region; other site 211110000452 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 211110000453 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 211110000454 substrate binding pocket [chemical binding]; other site 211110000455 membrane-bound complex binding site; other site 211110000456 hinge residues; other site 211110000457 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 211110000458 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 211110000459 dimer interface [polypeptide binding]; other site 211110000460 conserved gate region; other site 211110000461 putative PBP binding loops; other site 211110000462 ABC-ATPase subunit interface; other site 211110000463 Predicted membrane protein (DUF2207); Region: DUF2207; pfam09972 211110000464 undecaprenyl pyrophosphate phosphatase; Reviewed; Region: PRK00281 211110000465 adaptor protein; Provisional; Region: PRK02315 211110000466 UDP-N-acetylmuramyl pentapeptide phosphotransferase/UDP-N- acetylglucosamine-1-phosphate transferase [Cell envelope biogenesis, outer membrane]; Region: Rfe; COG0472 211110000467 This subfamily contains Escherichia coli WecA, Bacillus subtilis TagO and related proteins. WecA is an UDP-N-acetylglucosamine (GlcNAc):undecaprenyl-phosphate (Und-P) GlcNAc-1-phosphate transferase that catalyzes the formation of a phosphodiester bond...; Region: GT_WecA_like; cd06853 211110000468 Mg++ binding site [ion binding]; other site 211110000469 putative catalytic motif [active] 211110000470 substrate binding site [chemical binding]; other site 211110000471 Cysteine desulfurase activator ATPase [Posttranslational modification, protein turnover, chaperones]; Region: sufC; COG0396 211110000472 ABC-type transport system involved in Fe-S cluster assembly, ATPase component; Region: ABC_FeS_Assembly; cd03217 211110000473 Walker A/P-loop; other site 211110000474 ATP binding site [chemical binding]; other site 211110000475 Q-loop/lid; other site 211110000476 ABC transporter signature motif; other site 211110000477 Walker B; other site 211110000478 D-loop; other site 211110000479 H-loop/switch region; other site 211110000480 Cysteine desulfurase activator SufB [Posttranslational modification, protein turnover, chaperones]; Region: SufB; COG0719 211110000481 FeS assembly protein SufD; Region: sufD; TIGR01981 211110000482 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 211110000483 Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453 211110000484 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 211110000485 catalytic residue [active] 211110000486 NifU homolog involved in Fe-S cluster formation [Energy production and conversion]; Region: IscU; COG0822 211110000487 Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664 211110000488 trimerization site [polypeptide binding]; other site 211110000489 active site 211110000490 cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814; cl03223 211110000491 FeS assembly protein SufB; Region: sufB; TIGR01980 211110000492 D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768 211110000493 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 211110000494 D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: DacC; COG1686 211110000495 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 211110000496 Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; pfam07943 211110000497 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 211110000498 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 211110000499 peptide binding site [polypeptide binding]; other site 211110000500 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 211110000501 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 211110000502 dimer interface [polypeptide binding]; other site 211110000503 conserved gate region; other site 211110000504 putative PBP binding loops; other site 211110000505 ABC-ATPase subunit interface; other site 211110000506 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 211110000507 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 211110000508 dimer interface [polypeptide binding]; other site 211110000509 conserved gate region; other site 211110000510 putative PBP binding loops; other site 211110000511 ABC-ATPase subunit interface; other site 211110000512 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 211110000513 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 211110000514 Walker A/P-loop; other site 211110000515 ATP binding site [chemical binding]; other site 211110000516 Q-loop/lid; other site 211110000517 ABC transporter signature motif; other site 211110000518 Walker B; other site 211110000519 D-loop; other site 211110000520 H-loop/switch region; other site 211110000521 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 211110000522 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 211110000523 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 211110000524 Walker A/P-loop; other site 211110000525 ATP binding site [chemical binding]; other site 211110000526 Q-loop/lid; other site 211110000527 ABC transporter signature motif; other site 211110000528 Walker B; other site 211110000529 D-loop; other site 211110000530 H-loop/switch region; other site 211110000531 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352 211110000532 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: ipk; PRK00128 211110000533 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 211110000534 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 211110000535 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 211110000536 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 211110000537 putative Zn2+ binding site [ion binding]; other site 211110000538 putative DNA binding site [nucleotide binding]; other site 211110000539 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 211110000540 cell division ATP-binding protein FtsE; Region: FtsE; TIGR02673 211110000541 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 211110000542 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 211110000543 ABC-ATPase subunit interface; other site 211110000544 dimer interface [polypeptide binding]; other site 211110000545 putative PBP binding regions; other site 211110000546 DNA/RNA non-specific endonuclease; Region: Endonuclease_NS; smart00892 211110000547 DNA/RNA non-specific endonuclease; Region: Endonuclea_NS_2; cl17626 211110000548 tyrosyl-tRNA synthetase; Validated; Region: PRK05912 211110000549 catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805 211110000550 active site 211110000551 HIGH motif; other site 211110000552 dimer interface [polypeptide binding]; other site 211110000553 KMSKS motif; other site 211110000554 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 211110000555 RNA binding surface [nucleotide binding]; other site 211110000556 Membrane carboxypeptidase (penicillin-binding protein) [Cell envelope biogenesis, outer membrane]; Region: MrcB; COG0744 211110000557 Transglycosylase; Region: Transgly; pfam00912 211110000558 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 211110000559 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585 211110000560 RNA polymerase Rpb2, domain 2; Region: RNA_pol_Rpb2_2; pfam04561 211110000561 DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405 211110000562 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 211110000563 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 211110000564 RPB1 interaction site [polypeptide binding]; other site 211110000565 RPB10 interaction site [polypeptide binding]; other site 211110000566 RPB11 interaction site [polypeptide binding]; other site 211110000567 RPB3 interaction site [polypeptide binding]; other site 211110000568 RPB12 interaction site [polypeptide binding]; other site 211110000569 DNA-directed RNA polymerase subunit beta'; Provisional; Region: PRK00566 211110000570 RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997 211110000571 RNA polymerase I subunit A N-terminus; Region: RPOLA_N; smart00663 211110000572 RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983 211110000573 RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000 211110000574 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 211110000575 Rpb1 (beta') - Rpb6 (omega) interaction site [polypeptide binding]; other site 211110000576 G-loop; other site 211110000577 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 211110000578 DNA binding site [nucleotide binding] 211110000579 Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site 211110000580 Protein of unknown function (DUF1033); Region: DUF1033; pfam06279 211110000581 Type II/IV secretion system protein; Region: T2SE; pfam00437 211110000582 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 211110000583 Walker A motif; other site 211110000584 ATP binding site [chemical binding]; other site 211110000585 Walker B motif; other site 211110000586 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 211110000587 Type II secretory pathway, component PulF [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulF; COG1459 211110000588 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 211110000589 Competence protein ComGC [Intracellular trafficking and secretion]; Region: ComGC; COG4537 211110000590 Type II secretory pathway, pseudopilin PulG [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulG; COG2165 211110000591 Type II secretory pathway pseudopilin; Region: PulG; pfam11773 211110000592 Competence protein ComGF [Intracellular trafficking and secretion]; Region: ComGF; COG4940 211110000593 Adenine-specific DNA methylase [DNA replication, recombination, and repair]; Region: COG0827 211110000594 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 211110000595 S-adenosylmethionine binding site [chemical binding]; other site 211110000596 acetate kinase A/propionate kinase 2; Reviewed; Region: PRK00180 211110000597 propionate/acetate kinase; Provisional; Region: PRK12379 211110000598 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 211110000599 non-specific DNA binding site [nucleotide binding]; other site 211110000600 salt bridge; other site 211110000601 sequence-specific DNA binding site [nucleotide binding]; other site 211110000602 CAAX protease self-immunity; Region: Abi; pfam02517 211110000603 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232 211110000604 pyrroline-5-carboxylate reductase; Reviewed; Region: PRK11880 211110000605 Cellulase M and related proteins [Carbohydrate transport and metabolism]; Region: FrvX; COG1363 211110000606 M42 Peptidases, also known as glutamyl aminopeptidase family; Region: M42; cd05638 211110000607 oligomer interface [polypeptide binding]; other site 211110000608 active site 211110000609 metal binding site [ion binding]; metal-binding site 211110000610 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 211110000611 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 211110000612 catalytic residues [active] 211110000613 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 211110000614 putative tRNA-binding site [nucleotide binding]; other site 211110000615 Methyltransferase domain; Region: Methyltransf_23; pfam13489 211110000616 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 211110000617 S-adenosylmethionine binding site [chemical binding]; other site 211110000618 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 211110000619 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 211110000620 dimer interface [polypeptide binding]; other site 211110000621 ssDNA binding site [nucleotide binding]; other site 211110000622 tetramer (dimer of dimers) interface [polypeptide binding]; other site 211110000623 Predicted phosphatase/phosphohexomutase [General function prediction only]; Region: COG0637 211110000624 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 211110000625 motif II; other site 211110000626 Putative regulator of cell autolysis [Signal transduction mechanisms]; Region: LytS; COG3275 211110000627 5TMR of 5TMR-LYT; Region: 5TM-5TMR_LYT; pfam07694 211110000628 GAF domain; Region: GAF_3; pfam13492 211110000629 Histidine kinase; Region: His_kinase; pfam06580 211110000630 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 211110000631 ATP binding site [chemical binding]; other site 211110000632 Mg2+ binding site [ion binding]; other site 211110000633 G-X-G motif; other site 211110000634 two-component response regulator; Provisional; Region: PRK14084 211110000635 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 211110000636 active site 211110000637 phosphorylation site [posttranslational modification] 211110000638 intermolecular recognition site; other site 211110000639 dimerization interface [polypeptide binding]; other site 211110000640 LytTr DNA-binding domain; Region: LytTR; pfam04397 211110000641 LrgA family; Region: LrgA; cl00608 211110000642 LrgB-like family; Region: LrgB; cl00596 211110000643 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 211110000644 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_19; cd08518 211110000645 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 211110000646 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 211110000647 dimer interface [polypeptide binding]; other site 211110000648 conserved gate region; other site 211110000649 putative PBP binding loops; other site 211110000650 ABC-ATPase subunit interface; other site 211110000651 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 211110000652 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 211110000653 dimer interface [polypeptide binding]; other site 211110000654 conserved gate region; other site 211110000655 putative PBP binding loops; other site 211110000656 ABC-ATPase subunit interface; other site 211110000657 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 211110000658 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 211110000659 Walker A/P-loop; other site 211110000660 ATP binding site [chemical binding]; other site 211110000661 Q-loop/lid; other site 211110000662 ABC transporter signature motif; other site 211110000663 Walker B; other site 211110000664 D-loop; other site 211110000665 H-loop/switch region; other site 211110000666 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 211110000667 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 211110000668 Walker A/P-loop; other site 211110000669 ATP binding site [chemical binding]; other site 211110000670 Q-loop/lid; other site 211110000671 ABC transporter signature motif; other site 211110000672 Walker B; other site 211110000673 D-loop; other site 211110000674 H-loop/switch region; other site 211110000675 PTS system, trehalose-specific IIBC component; Region: PTS-IIBC-Tre; TIGR01992 211110000676 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 211110000677 active site turn [active] 211110000678 phosphorylation site [posttranslational modification] 211110000679 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 211110000680 Phosphotransferase system IIA components [Carbohydrate transport and metabolism]; Region: NagE; COG2190 211110000681 HPr interaction site; other site 211110000682 glycerol kinase (GK) interaction site [polypeptide binding]; other site 211110000683 active site 211110000684 phosphorylation site [posttranslational modification] 211110000685 alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403 211110000686 Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333 211110000687 Ca binding site [ion binding]; other site 211110000688 active site 211110000689 catalytic site [active] 211110000690 Transcriptional antiterminator [Transcription]; Region: BglG; COG3711 211110000691 PRD domain; Region: PRD; pfam00874 211110000692 PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568 211110000693 active site 211110000694 P-loop; other site 211110000695 phosphorylation site [posttranslational modification] 211110000696 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 211110000697 active site 211110000698 phosphorylation site [posttranslational modification] 211110000699 PTS_IIB_ascorbate: subunit IIB of enzyme II (EII) of the L-ascorbate-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is an L-ascorbate-specific permease with two cytoplasmic subunits (IIA and IIB) and a...; Region: PTS_IIB_ascorbate; cd05563 211110000700 active site 211110000701 P-loop; other site 211110000702 phosphorylation site [posttranslational modification] 211110000703 PTS system ascorbate-specific transporter subunit IIC; Reviewed; Region: ulaA; PRK09410 211110000704 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 211110000705 TPP-binding site [chemical binding]; other site 211110000706 dimer interface [polypeptide binding]; other site 211110000707 Transketolase, C-terminal subunit [Carbohydrate transport and metabolism]; Region: COG3958 211110000708 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 211110000709 PYR/PP interface [polypeptide binding]; other site 211110000710 dimer interface [polypeptide binding]; other site 211110000711 TPP binding site [chemical binding]; other site 211110000712 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 211110000713 Ferric reductase like transmembrane component; Region: Ferric_reduct; pfam01794 211110000714 NAD(P) binding domain of ferredoxin reductase-like proteins catalyze electron transfer between an NAD(P)-binding sub-domain of the alpha/beta class and a discrete (usually N-terminal) domain, which varies in orientation with respect to the NAD(P)...; Region: FNR_like_3; cd06198 211110000715 FAD binding pocket [chemical binding]; other site 211110000716 FAD binding motif [chemical binding]; other site 211110000717 phosphate binding motif [ion binding]; other site 211110000718 beta-alpha-beta structure motif; other site 211110000719 NAD binding pocket [chemical binding]; other site 211110000720 Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353 211110000721 16S/18S rRNA binding site [nucleotide binding]; other site 211110000722 S13e-L30e interaction site [polypeptide binding]; other site 211110000723 25S rRNA binding site [nucleotide binding]; other site 211110000724 polynucleotide phosphorylase/polyadenylase; Provisional; Region: PRK11824 211110000725 Polyribonucleotide nucleotidyltransferase, repeat 1; Region: RNase_PH_PNPase_1; cd11363 211110000726 RNase E interface [polypeptide binding]; other site 211110000727 trimer interface [polypeptide binding]; other site 211110000728 Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364 211110000729 RNase E interface [polypeptide binding]; other site 211110000730 trimer interface [polypeptide binding]; other site 211110000731 active site 211110000732 Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393 211110000733 S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472 211110000734 RNA binding site [nucleotide binding]; other site 211110000735 domain interface; other site 211110000736 Serine acetyltransferase [Amino acid transport and metabolism]; Region: CysE; COG1045 211110000737 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354 211110000738 trimer interface [polypeptide binding]; other site 211110000739 active site 211110000740 substrate binding site [chemical binding]; other site 211110000741 cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260 211110000742 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 211110000743 active site 211110000744 HIGH motif; other site 211110000745 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 211110000746 KMSKS motif; other site 211110000747 Anticodon-binding domain of cysteinyl tRNA synthetases; Region: Anticodon_Ia_Cys; cd07963 211110000748 tRNA binding surface [nucleotide binding]; other site 211110000749 anticodon binding site; other site 211110000750 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 211110000751 active site 211110000752 metal binding site [ion binding]; metal-binding site 211110000753 dimerization interface [polypeptide binding]; other site 211110000754 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 211110000755 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032 211110000756 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 211110000757 YacP-like NYN domain; Region: NYN_YacP; cl01491 211110000758 EDD domain protein, DegV family; Region: DegV; TIGR00762 211110000759 Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645 211110000760 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 211110000761 non-specific DNA binding site [nucleotide binding]; other site 211110000762 salt bridge; other site 211110000763 sequence-specific DNA binding site [nucleotide binding]; other site 211110000764 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 211110000765 Helix-turn-helix domain; Region: HTH_38; pfam13936 211110000766 Integrase core domain; Region: rve; pfam00665 211110000767 Ribosomal protein L13. Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392 211110000768 23S rRNA interface [nucleotide binding]; other site 211110000769 L3 interface [polypeptide binding]; other site 211110000770 30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132 211110000771 Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582 211110000772 phiLC3 phage and phage-related integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes various bacterial (mainly gram positive) and phage integrases, including those similar to Lactococcus...; Region: INT_phiLC3_C; cd01189 211110000773 Int/Topo IB signature motif; other site 211110000774 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 211110000775 sequence-specific DNA binding site [nucleotide binding]; other site 211110000776 salt bridge; other site 211110000777 Replication initiator protein A (RepA) N-terminus; Region: RepA_N; pfam06970 211110000778 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 211110000779 Replication initiation factor; Region: Rep_trans; pfam02486 211110000780 Plasmid recombination enzyme; Region: Mob_Pre; pfam01076 211110000781 addiction module toxin, RelE/StbE family; Region: RelE_StbE; TIGR02385 211110000782 WXG100 family type VII secretion target; Region: WXG100_ESAT6; TIGR03930 211110000783 pseudogene;Unknown 211110000784 Aluminium activated malate transporter; Region: ALMT; pfam11744 211110000785 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 211110000786 non-specific DNA binding site [nucleotide binding]; other site 211110000787 salt bridge; other site 211110000788 sequence-specific DNA binding site [nucleotide binding]; other site 211110000789 transcriptional activator, Rgg/GadR/MutR family, C-terminal domain; Region: RGG_Cterm; TIGR01716 211110000790 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 211110000791 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 211110000792 dimer interface [polypeptide binding]; other site 211110000793 conserved gate region; other site 211110000794 ABC-ATPase subunit interface; other site 211110000795 Periplasmic glycine betaine/choline-binding (lipo)protein of an ABC-type transport system (osmoprotectant binding protein) [Cell envelope biogenesis, outer membrane]; Region: OpuBC; COG1732 211110000796 ABC-type proline/glycine betaine transport systems, periplasmic components [Amino acid transport and metabolism]; Region: ProX; cl17891 211110000797 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 211110000798 dimer interface [polypeptide binding]; other site 211110000799 conserved gate region; other site 211110000800 putative PBP binding loops; other site 211110000801 ABC-ATPase subunit interface; other site 211110000802 ABC-type proline/glycine betaine transport systems, ATPase components [Amino acid transport and metabolism]; Region: OpuBA; COG1125 211110000803 ATP-binding cassette domain of the osmoprotectant transporter; Region: ABC_OpuCA_Osmoprotection; cd03295 211110000804 Walker A/P-loop; other site 211110000805 ATP binding site [chemical binding]; other site 211110000806 Q-loop/lid; other site 211110000807 ABC transporter signature motif; other site 211110000808 Walker B; other site 211110000809 D-loop; other site 211110000810 H-loop/switch region; other site 211110000811 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in association with the ABC transporter OpuCA. OpuCA is the ATP binding component of a bacterial solute transporter that serves a protective role to cells growing...; Region: CBS_pair_ABC_OpuCA_assoc2; cd04583 211110000812 Protein of unknown function (DUF2971); Region: DUF2971; pfam11185 211110000813 integrase; Provisional; Region: int; PHA02601 211110000814 phiLC3 phage and phage-related integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes various bacterial (mainly gram positive) and phage integrases, including those similar to Lactococcus...; Region: INT_phiLC3_C; cd01189 211110000815 Int/Topo IB signature motif; other site 211110000816 Domain of unknown function (DUF3173); Region: DUF3173; pfam11372 211110000817 putative replication initiation protein; Region: PHA00330 211110000818 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 211110000819 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 211110000820 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 211110000821 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 211110000822 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 211110000823 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 211110000824 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 211110000825 Sigma factor regulator C-terminal; Region: Sigma_reg_C; pfam13791 211110000826 DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595 211110000827 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 211110000828 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 211110000829 DNA binding residues [nucleotide binding] 211110000830 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 211110000831 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 211110000832 ABC-type Na+ efflux pump, permease component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatB; COG1668 211110000833 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 211110000834 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 211110000835 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 211110000836 ATP-binding cassette domain of the lipid transporters, subfamily A; Region: ABC_subfamily_A; cd03263 211110000837 Walker A/P-loop; other site 211110000838 ATP binding site [chemical binding]; other site 211110000839 Q-loop/lid; other site 211110000840 ABC transporter signature motif; other site 211110000841 Walker B; other site 211110000842 D-loop; other site 211110000843 H-loop/switch region; other site 211110000844 Protein of unknown function (DUF1129); Region: DUF1129; cl11555 211110000845 Predicted transcriptional regulators [Transcription]; Region: COG1695 211110000846 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 211110000847 N-acetylglucosamine-6-phosphate deacetylase [Carbohydrate transport and metabolism]; Region: NagA; COG1820 211110000848 N-acetylglucosamine-6-phosphate deacetylase, NagA, catalyzes the hydrolysis of the N-acetyl group of N-acetyl-glucosamine-6-phosphate (GlcNAc-6-P) to glucosamine 6-phosphate and acetate. This is the first committed step in the biosynthetic pathway to...; Region: NagA; cd00854 211110000849 active site 211110000850 dimer interface [polypeptide binding]; other site 211110000851 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1755 211110000852 Class II Glycyl-tRNA synthetase (GlyRS) alpha subunit core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes and in arabidopsis. It is responsible for the...; Region: GlyRS_alpha_core; cd00733 211110000853 dimer interface [polypeptide binding]; other site 211110000854 motif 1; other site 211110000855 active site 211110000856 motif 2; other site 211110000857 motif 3; other site 211110000858 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 211110000859 glycyl-tRNA synthetase subunit beta; Validated; Region: glyS; PRK01233 211110000860 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl17215 211110000861 DALR anticodon binding domain; Region: DALR_1; pfam05746 211110000862 hypothetical protein; Provisional; Region: PRK02539 211110000863 Predicted membrane protein [Function unknown]; Region: COG3326 211110000864 glycerol kinase; Provisional; Region: glpK; PRK00047 211110000865 Escherichia coli glycerol kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_EcGK_like; cd07786 211110000866 N- and C-terminal domain interface [polypeptide binding]; other site 211110000867 active site 211110000868 MgATP binding site [chemical binding]; other site 211110000869 catalytic site [active] 211110000870 metal binding site [ion binding]; metal-binding site 211110000871 glycerol binding site [chemical binding]; other site 211110000872 homotetramer interface [polypeptide binding]; other site 211110000873 homodimer interface [polypeptide binding]; other site 211110000874 FBP binding site [chemical binding]; other site 211110000875 protein IIAGlc interface [polypeptide binding]; other site 211110000876 Glycerol-3-phosphate dehydrogenase [Energy production and conversion]; Region: GlpA; COG0578 211110000877 Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cd00333 211110000878 amphipathic channel; other site 211110000879 Asn-Pro-Ala signature motifs; other site 211110000880 Uncharacterized NAD(FAD)-dependent dehydrogenases [General function prediction only]; Region: HcaD; COG0446 211110000881 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 211110000882 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 211110000883 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 211110000884 Mga helix-turn-helix domain; Region: Mga; pfam05043 211110000885 Transketolase [Carbohydrate transport and metabolism]; Region: TktA; COG0021 211110000886 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 211110000887 TPP-binding site [chemical binding]; other site 211110000888 dimer interface [polypeptide binding]; other site 211110000889 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 211110000890 PYR/PP interface [polypeptide binding]; other site 211110000891 dimer interface [polypeptide binding]; other site 211110000892 TPP binding site [chemical binding]; other site 211110000893 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 211110000894 Enterocin A Immunity; Region: EntA_Immun; pfam08951 211110000895 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 211110000896 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 211110000897 Walker A/P-loop; other site 211110000898 ATP binding site [chemical binding]; other site 211110000899 Q-loop/lid; other site 211110000900 ABC transporter signature motif; other site 211110000901 Walker B; other site 211110000902 D-loop; other site 211110000903 H-loop/switch region; other site 211110000904 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 211110000905 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 211110000906 PTS system, sucrose-specific IIBC component; Region: PTS-II-BC-sucr; TIGR01996 211110000907 active site turn [active] 211110000908 phosphorylation site [posttranslational modification] 211110000909 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 211110000910 Glutamate 5-kinase [Amino acid transport and metabolism]; Region: ProB; COG0263 211110000911 AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242 211110000912 nucleotide binding site [chemical binding]; other site 211110000913 homotetrameric interface [polypeptide binding]; other site 211110000914 putative phosphate binding site [ion binding]; other site 211110000915 putative allosteric binding site; other site 211110000916 Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079 211110000917 gamma-glutamyl phosphate reductase; Region: proA; TIGR00407 211110000918 putative catalytic cysteine [active] 211110000919 Predicted S-adenosylmethionine-dependent methyltransferase involved in cell envelope biogenesis [Cell envelope biogenesis, outer membrane]; Region: COG0275 211110000920 MraW methylase family; Region: Methyltransf_5; pfam01795 211110000921 Protein required for the initiation of cell division [Cell division and chromosome partitioning]; Region: FtsL; COG4839 211110000922 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 211110000923 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 211110000924 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 211110000925 PASTA domain of PBP2x-like proteins, first repeat. Penicillin-binding proteins (PBPs) are the major targets for beta-lactam antibiotics, like penicillins and cephalosporins. Beta-lactam antibiotics specifically inhibit transpeptidase activity by...; Region: PASTA_Pbp2x-like_1; cd06576 211110000926 PASTA domain of PBP2x-like proteins, second repeat. Penicillin-binding proteins (PBPs) are the major targets for beta-lactam antibiotics, like penicillins and cephalosporins. Beta-lactam antibiotics specifically inhibit transpeptidase activity by...; Region: PASTA_Pbp2x-like_2; cd06575 211110000927 phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108 211110000928 Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852 211110000929 Mg++ binding site [ion binding]; other site 211110000930 putative catalytic motif [active] 211110000931 putative substrate binding site [chemical binding]; other site 211110000932 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 211110000933 DEAD-like helicases superfamily; Region: DEXDc; smart00487 211110000934 ATP binding site [chemical binding]; other site 211110000935 Mg++ binding site [ion binding]; other site 211110000936 motif III; other site 211110000937 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 211110000938 nucleotide binding region [chemical binding]; other site 211110000939 ATP-binding site [chemical binding]; other site 211110000940 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 211110000941 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 211110000942 substrate binding pocket [chemical binding]; other site 211110000943 membrane-bound complex binding site; other site 211110000944 hinge residues; other site 211110000945 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 211110000946 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 211110000947 dimer interface [polypeptide binding]; other site 211110000948 conserved gate region; other site 211110000949 putative PBP binding loops; other site 211110000950 ABC-ATPase subunit interface; other site 211110000951 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 211110000952 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 211110000953 Walker A/P-loop; other site 211110000954 ATP binding site [chemical binding]; other site 211110000955 Q-loop/lid; other site 211110000956 ABC transporter signature motif; other site 211110000957 Walker B; other site 211110000958 D-loop; other site 211110000959 H-loop/switch region; other site 211110000960 Protein of unknown function (DUF4059); Region: DUF4059; pfam13268 211110000961 thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292 211110000962 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 211110000963 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 211110000964 nicotinate phosphoribosyltransferase; Validated; Region: PRK09243 211110000965 Nicotinate phosphoribosyltransferase (NAPRTase), subgroup A. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting, reaction...; Region: NAPRTase_A; cd01570 211110000966 active site 211110000967 NAD synthase [Coenzyme metabolism]; Region: NadE; COG0171 211110000968 NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553 211110000969 homodimer interface [polypeptide binding]; other site 211110000970 NAD binding pocket [chemical binding]; other site 211110000971 ATP binding pocket [chemical binding]; other site 211110000972 Mg binding site [ion binding]; other site 211110000973 active-site loop [active] 211110000974 Peptidase C1B subfamily (MEROPS database nomenclature); composed of eukaryotic bleomycin hydrolases (BH) and bacterial aminopeptidases C (pepC). The proteins of this subfamily contain a large insert relative to the C1A peptidase (papain) subfamily. BH is...; Region: Peptidase_C1B; cd00585 211110000975 trimer interface [polypeptide binding]; other site 211110000976 active site 211110000977 G bulge; other site 211110000978 Transglycosylase; Region: Transgly; pfam00912 211110000979 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 211110000980 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 211110000981 Holliday junction-specific endonuclease; Reviewed; Region: recU; PRK02234 211110000982 hypothetical protein; Provisional; Region: PRK13660 211110000983 cell division protein GpsB; Provisional; Region: PRK14127 211110000984 DivIVA domain; Region: DivI1A_domain; TIGR03544 211110000985 Predicted N6-adenine-specific DNA methylase [DNA replication, recombination, and repair]; Region: COG0116 211110000986 THUMP domain associated with S-adenosylmethionine-dependent methyltransferases; Region: THUMP_AdoMetMT; cd11715 211110000987 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 211110000988 S-ribosylhomocysteinase; Provisional; Region: PRK02260 211110000989 hypothetical protein; Provisional; Region: PRK00106 211110000990 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 211110000991 Zn2+ binding site [ion binding]; other site 211110000992 Mg2+ binding site [ion binding]; other site 211110000993 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 211110000994 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 211110000995 Walker A/P-loop; other site 211110000996 ATP binding site [chemical binding]; other site 211110000997 Q-loop/lid; other site 211110000998 ABC transporter signature motif; other site 211110000999 Walker B; other site 211110001000 D-loop; other site 211110001001 H-loop/switch region; other site 211110001002 ABC-2 type transporter; Region: ABC2_membrane; cl17235 211110001003 ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698 211110001004 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 211110001005 Cytidylyltransferase family; Region: CTP_transf_1; cl17467 211110001006 Histidine kinase; Region: HisKA_3; pfam07730 211110001007 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 211110001008 Mg2+ binding site [ion binding]; other site 211110001009 G-X-G motif; other site 211110001010 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 211110001011 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 211110001012 active site 211110001013 phosphorylation site [posttranslational modification] 211110001014 intermolecular recognition site; other site 211110001015 dimerization interface [polypeptide binding]; other site 211110001016 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 211110001017 DNA binding residues [nucleotide binding] 211110001018 dimerization interface [polypeptide binding]; other site 211110001019 Protein of unknown function (DUF1211); Region: DUF1211; pfam06736 211110001020 Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194 211110001021 Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071 211110001022 catalytic site [active] 211110001023 G-X2-G-X-G-K; other site 211110001024 DNA-directed RNA polymerase subunit omega; Reviewed; Region: rpoZ; PRK00392 211110001025 Primosomal protein N' (replication factor Y) - superfamily II helicase [DNA replication, recombination, and repair]; Region: PriA; COG1198 211110001026 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 211110001027 ATP binding site [chemical binding]; other site 211110001028 putative Mg++ binding site [ion binding]; other site 211110001029 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 211110001030 ATP-binding site [chemical binding]; other site 211110001031 methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005 211110001032 Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646 211110001033 putative active site [active] 211110001034 substrate binding site [chemical binding]; other site 211110001035 putative cosubstrate binding site; other site 211110001036 catalytic site [active] 211110001037 C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704 211110001038 substrate binding site [chemical binding]; other site 211110001039 16S rRNA methyltransferase B; Provisional; Region: PRK14902 211110001040 NusB family; Region: NusB; pfam01029 211110001041 putative RNA binding site [nucleotide binding]; other site 211110001042 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 211110001043 S-adenosylmethionine binding site [chemical binding]; other site 211110001044 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143 211110001045 active site 211110001046 Protein phosphatase 2C; Region: PP2C; pfam00481 211110001047 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 211110001048 Catalytic domain of Protein Kinases; Region: PKc; cd00180 211110001049 active site 211110001050 ATP binding site [chemical binding]; other site 211110001051 substrate binding site [chemical binding]; other site 211110001052 activation loop (A-loop); other site 211110001053 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 211110001054 PASTA domain; Region: PASTA; smart00740 211110001055 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 211110001056 Predicted membrane protein [Function unknown]; Region: COG4758 211110001057 Cell wall-active antibiotics response protein (DUF2154); Region: DUF2154; pfam09922 211110001058 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 211110001059 Histidine kinase; Region: HisKA_3; pfam07730 211110001060 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 211110001061 ATP binding site [chemical binding]; other site 211110001062 Mg2+ binding site [ion binding]; other site 211110001063 G-X-G motif; other site 211110001064 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 211110001065 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 211110001066 active site 211110001067 phosphorylation site [posttranslational modification] 211110001068 intermolecular recognition site; other site 211110001069 dimerization interface [polypeptide binding]; other site 211110001070 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 211110001071 DNA binding residues [nucleotide binding] 211110001072 dimerization interface [polypeptide binding]; other site 211110001073 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 211110001074 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 211110001075 active site 211110001076 motif I; other site 211110001077 motif II; other site 211110001078 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 211110001079 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317 211110001080 active site 211110001081 hypothetical protein; Provisional; Region: PRK07252 211110001082 Predicted RNA binding protein (contains ribosomal protein S1 domain) [Translation, ribosomal structure and biogenesis]; Region: VacB; COG1098 211110001083 RNA binding site [nucleotide binding]; other site 211110001084 glycyl-radical enzyme activating protein family; Region: PFLE_PFLC; TIGR02494 211110001085 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 211110001086 FeS/SAM binding site; other site 211110001087 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 211110001088 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; cl17531 211110001089 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 211110001090 Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription]; Region: DeoR; COG2390 211110001091 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 211110001092 DNA binding residues [nucleotide binding] 211110001093 Putative sugar-binding domain; Region: Sugar-bind; pfam04198 211110001094 PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_lac; cd00215 211110001095 active site 211110001096 methionine cluster; other site 211110001097 phosphorylation site [posttranslational modification] 211110001098 metal binding site [ion binding]; metal-binding site 211110001099 PTS_IIB_chitobiose_lichenan: subunit IIB of enzyme II (EII) of the N,N-diacetylchitobiose-specific and lichenan-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In these systems, EII is either a lichenan- or an N; Region: PTS_IIB_chitobiose_lichenan; cd05564 211110001100 active site 211110001101 P-loop; other site 211110001102 phosphorylation site [posttranslational modification] 211110001103 Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455 211110001104 cellobiose phosphotransferase system IIC component; Reviewed; Region: celD; PRK09592 211110001105 Pyruvate-formate lyase [Energy production and conversion]; Region: PflD; COG1882 211110001106 Pyruvate formate lyase 2 and related enzymes; Region: PFL2_DhaB_BssA; cd01677 211110001107 dimer interface [polypeptide binding]; other site 211110001108 active site 211110001109 glycine loop; other site 211110001110 Transaldolase-like fructose-6-phosphate aldolases (FSA) found in bacteria and archaea; Region: Transaldolase_FSA; cd00956 211110001111 active site 211110001112 intersubunit interactions; other site 211110001113 catalytic residue [active] 211110001114 Glycerol dehydrogenase and related enzymes [Energy production and conversion]; Region: GldA; COG0371 211110001115 Glycerol dehydrogenases (GlyDH) catalyzes oxidation of glycerol to dihydroxyacetone in glycerol dissmilation; Region: GlyDH; cd08170 211110001116 dimer interface [polypeptide binding]; other site 211110001117 active site 211110001118 metal binding site [ion binding]; metal-binding site 211110001119 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 211110001120 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 211110001121 dimer interface [polypeptide binding]; other site 211110001122 pyridoxal 5'-phosphate binding site [chemical binding]; other site 211110001123 catalytic residue [active] 211110001124 Uncharacterized conserved protein [Function unknown]; Region: COG1739 211110001125 Uncharacterized protein family UPF0029; Region: UPF0029; pfam01205 211110001126 Domain of unknown function (DUF1949); Region: DUF1949; pfam09186 211110001127 Superfamily II DNA/RNA helicase required for DNA uptake (late competence protein) [DNA replication, recombination, and repair]; Region: comFA; COG4098 211110001128 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 211110001129 ATP binding site [chemical binding]; other site 211110001130 putative Mg++ binding site [ion binding]; other site 211110001131 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 211110001132 nucleotide binding region [chemical binding]; other site 211110001133 ATP-binding site [chemical binding]; other site 211110001134 Predicted amidophosphoribosyltransferases [General function prediction only]; Region: ComFC; COG1040 211110001135 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 211110001136 active site 211110001137 RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552 211110001138 30S subunit binding site; other site 211110001139 aspartate kinase; Reviewed; Region: PRK09034 211110001140 AAK_AKiii-YclM-BS: Amino Acid Kinase Superfamily (AAK), AKiii-YclM-BS; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the lysine plus threonine-sensitive aspartokinase isoenzyme AKIII, a monofunctional class enzyme found in...; Region: AAK_AKiii-YclM-BS; cd04245 211110001141 putative catalytic residues [active] 211110001142 putative nucleotide binding site [chemical binding]; other site 211110001143 putative aspartate binding site [chemical binding]; other site 211110001144 ACT domains located C-terminal to the catalytic domain of the lysine plus threonine-sensitive aspartokinase isoenzyme AKIII; Region: ACT_AKiii-YclM-BS_1; cd04911 211110001145 allosteric regulatory residue; other site 211110001146 ACT domains located C-terminal to the catalytic domain of the lysine plus threonine-sensitive aspartokinase isoenzyme AKIII; Region: ACT_AKiii-YclM-BS_2; cd04916 211110001147 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 211110001148 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 211110001149 motif II; other site 211110001150 enoyl-CoA hydratase; Provisional; Region: PRK07260 211110001151 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 211110001152 substrate binding site [chemical binding]; other site 211110001153 oxyanion hole (OAH) forming residues; other site 211110001154 trimer interface [polypeptide binding]; other site 211110001155 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 211110001156 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 211110001157 putative Zn2+ binding site [ion binding]; other site 211110001158 putative DNA binding site [nucleotide binding]; other site 211110001159 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352 211110001160 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 211110001161 dimer interface [polypeptide binding]; other site 211110001162 active site 211110001163 CoA binding pocket [chemical binding]; other site 211110001164 acyl carrier protein; Provisional; Region: acpP; PRK00982 211110001165 putative enoyl-[acyl-carrier-protein] reductase II; Region: enACPred_II; TIGR03151 211110001166 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 211110001167 FMN binding site [chemical binding]; other site 211110001168 substrate binding site [chemical binding]; other site 211110001169 putative catalytic residue [active] 211110001170 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 211110001171 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 211110001172 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 211110001173 beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333 211110001174 NAD(P) binding site [chemical binding]; other site 211110001175 homotetramer interface [polypeptide binding]; other site 211110001176 homodimer interface [polypeptide binding]; other site 211110001177 active site 211110001178 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 211110001179 3-oxoacyl-(acyl carrier protein) synthase II; Reviewed; Region: PRK07314 211110001180 dimer interface [polypeptide binding]; other site 211110001181 active site 211110001182 acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated; Region: PRK06302 211110001183 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 211110001184 carboxyltransferase (CT) interaction site; other site 211110001185 biotinylation site [posttranslational modification]; other site 211110001186 FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288 211110001187 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591 211110001188 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 211110001189 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 211110001190 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 211110001191 acetyl-CoA carboxylase subunit beta; Validated; Region: PRK05654 211110001192 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 211110001193 acetyl-CoA carboxylase subunit alpha; Provisional; Region: PRK12319 211110001194 Formate/glycerate dehydrogenases, D-specific 2-hydroxy acid dehydrogenases and related dehydrogenases; Region: FDH_GDH_like; cl17240 211110001195 seryl-tRNA synthetase; Provisional; Region: PRK05431 211110001196 Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403 211110001197 Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770 211110001198 dimer interface [polypeptide binding]; other site 211110001199 active site 211110001200 motif 1; other site 211110001201 motif 2; other site 211110001202 motif 3; other site 211110001203 Predicted O-acyltransferase [General function prediction only]; Region: COG3274 211110001204 Acyltransferase family; Region: Acyl_transf_3; pfam01757 211110001205 Domain of unknown function (DUF956); Region: DUF956; pfam06115 211110001206 Phosphotransferase system, mannose/fructose/N-acetylgalactosamine-specific component IID [Carbohydrate transport and metabolism]; Region: ManZ; COG3716 211110001207 PTS system mannose-specific transporter subunit IIC; Provisional; Region: PRK15065 211110001208 PTS system mannose-specific transporter subunits IIAB; Provisional; Region: PRK15088 211110001209 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006 211110001210 active pocket/dimerization site; other site 211110001211 active site 211110001212 phosphorylation site [posttranslational modification] 211110001213 PTS_IIB, PTS system, Mannose/sorbose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_man; cd00001 211110001214 active site 211110001215 phosphorylation site [posttranslational modification] 211110001216 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 211110001217 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 211110001218 active site 211110001219 motif I; other site 211110001220 motif II; other site 211110001221 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 211110001222 Protein of unknown function (DUF1361); Region: DUF1361; pfam07099 211110001223 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 211110001224 Predicted ATPase or kinase [General function prediction only]; Region: COG0802 211110001225 pseudaminic acid biosynthesis N-acetyl transferase; Region: PseH; TIGR03585 211110001226 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 211110001227 Coenzyme A binding pocket [chemical binding]; other site 211110001228 Transcriptional regulator [Transcription]; Region: LytR; COG1316 211110001229 HINT (histidine triad nucleotide-binding protein) subgroup: Members of this CD belong to the superfamily of histidine triad hydrolases that act on alpha-phosphate of ribonucleotides. This subgroup includes members from all three forms of cellular life; Region: HINT_subgroup; cd01277 211110001230 HIT family signature motif; other site 211110001231 catalytic residue [active] 211110001232 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 211110001233 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 211110001234 Walker A/P-loop; other site 211110001235 ATP binding site [chemical binding]; other site 211110001236 Q-loop/lid; other site 211110001237 ABC transporter signature motif; other site 211110001238 Walker B; other site 211110001239 D-loop; other site 211110001240 H-loop/switch region; other site 211110001241 Bacterial ABC transporter protein EcsB; Region: EcsB; pfam05975 211110001242 Primase C terminal 1 (PriCT-1); Region: PriCT_1; pfam08708 211110001243 Glutaredoxin-like domain (DUF836); Region: DUF836; cl17650 211110001244 Chromosome segregation ATPases [Cell division and chromosome partitioning]; Region: Smc; COG1196 211110001245 DNA/RNA non-specific endonuclease; Region: Endonuclea_NS_2; cl17626 211110001246 DNA/RNA non-specific endonuclease; Region: Endonuclease_NS; smart00892 211110001247 Protein of unknown function (DUF3991); Region: DUF3991; pfam13154 211110001248 Domain of unknown function (DUF955); Region: DUF955; pfam06114 211110001249 DNA topoisomerase III; Provisional; Region: PRK07726 211110001250 TOPRIM_TopoIA_TopoIII: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to topoisomerase III. Type IA DNA topoisomerases remove (relax) negative supercoils in the DNA by: cleaving...; Region: TOPRIM_TopoIA_TopoIII; cd03362 211110001251 active site 211110001252 putative interdomain interaction site [polypeptide binding]; other site 211110001253 putative metal-binding site [ion binding]; other site 211110001254 putative nucleotide binding site [chemical binding]; other site 211110001255 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 211110001256 domain I; other site 211110001257 DNA binding groove [nucleotide binding] 211110001258 phosphate binding site [ion binding]; other site 211110001259 domain II; other site 211110001260 domain III; other site 211110001261 nucleotide binding site [chemical binding]; other site 211110001262 catalytic site [active] 211110001263 domain IV; other site 211110001264 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 211110001265 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 211110001266 Walker A motif; other site 211110001267 ATP binding site [chemical binding]; other site 211110001268 Walker B motif; other site 211110001269 arginine finger; other site 211110001270 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 211110001271 Walker A motif; other site 211110001272 ATP binding site [chemical binding]; other site 211110001273 Walker B motif; other site 211110001274 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 211110001275 A sub-family of peptidase family C39. Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various...; Region: Peptidase_C39A; cd02549 211110001276 putative active site [active] 211110001277 LPXTG-motif cell wall anchor domain; Region: LPXTG_anchor; TIGR01167 211110001278 putative cross-wall-targeting lipoprotein signal; Region: strep_RK_lipo; TIGR03726 211110001279 Membrane protein involved in colicin uptake [Cell envelope biogenesis, outer membrane]; Region: TolA; COG3064 211110001280 adhesin isopeptide-forming domain, sspB-C2 type; Region: isopep_sspB_C2; TIGR04228 211110001281 LPXTG-motif cell wall anchor domain; Region: LPXTG_anchor; TIGR01167 211110001282 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 211110001283 dimer interface [polypeptide binding]; other site 211110001284 ssDNA binding site [nucleotide binding]; other site 211110001285 tetramer (dimer of dimers) interface [polypeptide binding]; other site 211110001286 kinesin-12 family protein; Provisional; Region: PLN03188 211110001287 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 211110001288 Walker A motif; other site 211110001289 ATP binding site [chemical binding]; other site 211110001290 Type IV secretory pathway, VirD4 components [Intracellular trafficking and secretion]; Region: VirD4; COG3505 211110001291 TraM recognition site of TraD and TraG; Region: TraG-D_C; pfam12696 211110001292 DNA polymerase III subunit epsilon; Validated; Region: PRK06195 211110001293 Lantibiotic dehydratase, C terminus; Region: Lant_dehyd_C; pfam04738 211110001294 AAA-like domain; Region: AAA_10; pfam12846 211110001295 Ribosomal protein L6e; Region: Ribosomal_L6e; pfam01159 211110001296 Mannosyl-glycoprotein endo-beta-N-acetylglucosaminidase; Region: Glucosaminidase; pfam01832 211110001297 CHAP domain; Region: CHAP; cl17642 211110001298 Antiactivator of flagellar biosynthesis FleN, an ATPase [Cell motility]; Region: flhG; COG0455 211110001299 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 211110001300 Replication initiator protein A (RepA) N-terminus; Region: RepA_N; pfam06970 211110001301 MarR family; Region: MarR_2; cl17246 211110001302 Uncharacterized protein family (UPF0236); Region: UPF0236; pfam06782 211110001303 Phosphotransferase enzyme family; Region: APH; pfam01636 211110001304 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120 211110001305 active site 211110001306 ATP binding site [chemical binding]; other site 211110001307 substrate binding site [chemical binding]; other site 211110001308 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 211110001309 S-adenosylmethionine binding site [chemical binding]; other site 211110001310 Uncharacterized BCR, YhbC family COG0779; Region: DUF150; pfam02576 211110001311 Bacillus subtilis YxlS-like, C-terminal domain; Region: YlxS_C; cd01734 211110001312 putative oligomer interface [polypeptide binding]; other site 211110001313 putative RNA binding site [nucleotide binding]; other site 211110001314 transcription elongation factor NusA; Provisional; Region: nusA; PRK12327 211110001315 NusA N-terminal domain; Region: NusA_N; pfam08529 211110001316 S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455 211110001317 RNA binding site [nucleotide binding]; other site 211110001318 homodimer interface [polypeptide binding]; other site 211110001319 NusA-like KH domain; Region: KH_5; pfam13184 211110001320 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 211110001321 G-X-X-G motif; other site 211110001322 Ylxr homologs; group of conserved hypothetical bacterial proteins of unknown function; structure revealed putative RNA binding cleft; proteins are encoded by an operon that includes other proteins involved in transcription and/or translation; Region: YlxR; cd00279 211110001323 putative RNA binding cleft [nucleotide binding]; other site 211110001324 hypothetical protein; Provisional; Region: PRK07283 211110001325 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 211110001326 translation initiation factor IF-2; Region: IF-2; TIGR00487 211110001327 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 211110001328 Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887 211110001329 G1 box; other site 211110001330 putative GEF interaction site [polypeptide binding]; other site 211110001331 GTP/Mg2+ binding site [chemical binding]; other site 211110001332 Switch I region; other site 211110001333 G2 box; other site 211110001334 G3 box; other site 211110001335 Switch II region; other site 211110001336 G4 box; other site 211110001337 G5 box; other site 211110001338 This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702 211110001339 Translation-initiation factor 2; Region: IF-2; pfam11987 211110001340 mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692 211110001341 ribosome-binding factor A; Validated; Region: rbfA; PRK00521 211110001342 Esterase/lipase [Lipid metabolism]; Region: Aes; COG0657 211110001343 Protein of unknown function (DUF2424); Region: DUF2424; pfam10340 211110001344 copper transport repressor, CopY/TcrY family; Region: CopY_TcrY; TIGR02698 211110001345 Penicillinase repressor; Region: Pencillinase_R; pfam03965 211110001346 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 211110001347 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 211110001348 metal-binding site [ion binding] 211110001349 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 211110001350 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 211110001351 motif II; other site 211110001352 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 211110001353 metal-binding site [ion binding] 211110001354 Predicted membrane protein [Function unknown]; Region: COG2860 211110001355 UPF0126 domain; Region: UPF0126; pfam03458 211110001356 UPF0126 domain; Region: UPF0126; pfam03458 211110001357 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 211110001358 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 211110001359 active site 211110001360 motif I; other site 211110001361 motif II; other site 211110001362 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 211110001363 DNA polymerase I; Provisional; Region: PRK05755 211110001364 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 211110001365 active site 211110001366 metal binding site 1 [ion binding]; metal-binding site 211110001367 putative 5' ssDNA interaction site; other site 211110001368 metal binding site 3; metal-binding site 211110001369 metal binding site 2 [ion binding]; metal-binding site 211110001370 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 211110001371 putative DNA binding site [nucleotide binding]; other site 211110001372 putative metal binding site [ion binding]; other site 211110001373 inactive DEDDy 3'-5' exonuclease domain of Bacillus stearothermophilus DNA polymerase I and similar family-A DNA polymerases; Region: DNA_polA_I_Bacillus_like_exo; cd06140 211110001374 Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637 211110001375 active site 211110001376 DNA binding site [nucleotide binding] 211110001377 catalytic site [active] 211110001378 Predicted CoA-binding protein [General function prediction only]; Region: COG1832 211110001379 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 211110001380 metal binding site 2 [ion binding]; metal-binding site 211110001381 putative DNA binding helix; other site 211110001382 metal binding site 1 [ion binding]; metal-binding site 211110001383 dimer interface [polypeptide binding]; other site 211110001384 structural Zn2+ binding site [ion binding]; other site 211110001385 YSIRK type signal peptide; Region: YSIRK_signal; cl04650 211110001386 Fibronectin-binding repeat; Region: SSURE; pfam11966 211110001387 Fibronectin-binding repeat; Region: SSURE; pfam11966 211110001388 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 211110001389 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 211110001390 active site 211110001391 phosphorylation site [posttranslational modification] 211110001392 intermolecular recognition site; other site 211110001393 dimerization interface [polypeptide binding]; other site 211110001394 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 211110001395 DNA binding site [nucleotide binding] 211110001396 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 211110001397 HAMP domain; Region: HAMP; pfam00672 211110001398 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 211110001399 dimer interface [polypeptide binding]; other site 211110001400 phosphorylation site [posttranslational modification] 211110001401 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 211110001402 ATP binding site [chemical binding]; other site 211110001403 Mg2+ binding site [ion binding]; other site 211110001404 G-X-G motif; other site 211110001405 Protein of unknown function (DUF975); Region: DUF975; pfam06161 211110001406 queuine tRNA-ribosyltransferase; Provisional; Region: tgt; PRK00112 211110001407 Queuine/archaeosine tRNA-ribosyltransferase [Translation, ribosomal structure and biogenesis]; Region: Tgt; COG0343 211110001408 Zinc finger domain containing protein (CHY type) [Function unknown]; Region: COG4357 211110001409 CHY zinc finger; Region: zf-CHY; pfam05495 211110001410 Uncharacterized conserved protein [General function prediction only]; Region: BioY; COG1268 211110001411 Metal-dependent hydrolases of the beta-lactamase superfamily III [General function prediction only]; Region: ElaC; COG1234 211110001412 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 211110001413 nucleoside/Zn binding site; other site 211110001414 dimer interface [polypeptide binding]; other site 211110001415 catalytic motif [active] 211110001416 glucose-6-phosphate isomerase; Provisional; Region: pgi; PRK14097 211110001417 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015 211110001418 active site 211110001419 dimer interface [polypeptide binding]; other site 211110001420 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016 211110001421 dimer interface [polypeptide binding]; other site 211110001422 active site 211110001423 5-formyltetrahydrofolate cyclo-ligase family; Region: 5-FTHF_cyc-lig; pfam01812 211110001424 5,10-methenyltetrahydrofolate synthetase; Region: MTHFS_bact; TIGR02727 211110001425 Rhomboid family; Region: Rhomboid; pfam01694 211110001426 Uncharacterized ABC-type transport system, periplasmic component/surface lipoprotein [General function prediction only]; Region: Med; COG1744 211110001427 Periplasmic binding domain of basic membrane lipoprotein, PnrA, in Treponema pallidum and its homologs from other bacteria and Archaea; Region: PBP1_BmpA_PnrA_like; cd06354 211110001428 ligand binding site [chemical binding]; other site 211110001429 Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541 211110001430 dTDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: RfbA; COG1209 211110001431 active site 211110001432 tetramer interface; other site 211110001433 NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094 211110001434 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 211110001435 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479 211110001436 ribonuclease P; Reviewed; Region: rnpA; PRK00499 211110001437 Preprotein translocase subunit YidC [Intracellular trafficking and secretion]; Region: YidC; COG0706 211110001438 membrane protein insertase, YidC/Oxa1 family, C-terminal domain; Region: yidC_oxa1_cterm; TIGR03592 211110001439 Predicted RNA-binding protein [General function prediction only]; Region: Jag; COG1847 211110001440 jag_K homology RNA-binding domain. The KH domain is found in proteins homologous to the Bacillus subtilis protein Jag, which is associated with SpoIIIJ and is necessary for the third stage of sporulation. The KH motif is a beta-alpha-alpha-beta-beta...; Region: jag_KH; cd02414 211110001441 G-X-X-G motif; other site 211110001442 R3H domain found in proteins homologous to Bacillus subtilus Jag, which is associated with SpoIIIJ. SpoIIIJ is necessary for the third stage of sporulation. The name of the R3H domain comes from the characteristic spacing of the most conserved arginine...; Region: R3H_jag; cd02644 211110001443 RxxxH motif; other site 211110001444 hypothetical protein; Provisional; Region: PRK13662 211110001445 recombination regulator RecX; Provisional; Region: recX; PRK14135 211110001446 SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase [Translation, ribosomal structure and biogenesis]; Region: TrmA; COG2265 211110001447 TRAM domain; Region: TRAM; pfam01938 211110001448 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 211110001449 S-adenosylmethionine binding site [chemical binding]; other site 211110001450 Phosphorylase superfamily; Region: PNP_UDP_1; pfam01048 211110001451 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 211110001452 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 211110001453 Coenzyme A binding pocket [chemical binding]; other site 211110001454 Peptidase S8 family domain in Streptococcal C5a peptidases; Region: Peptidases_S8_C5a_Peptidase; cd07475 211110001455 putative active site [active] 211110001456 catalytic triad [active] 211110001457 PA_C5a_like: Protease-associated domain containing proteins like Streptococcus pyogenes C5a peptidase. This group contains various PA domain-containing proteins similar to S. pyogenes C5a, including, i) Vpr, a minor extracellular serine protease from...; Region: PA_C5a_like; cd02133 211110001458 PA/protease domain interface [polypeptide binding]; other site 211110001459 putative integrin binding motif; other site 211110001460 Peptidase S8 family domain in Streptococcal C5a peptidases; Region: Peptidases_S8_C5a_Peptidase; cd07475 211110001461 Fn3-like domain (DUF1034); Region: DUF1034; pfam06280 211110001462 C-terminal domain of CHU protein family; Region: CHU_C; cl17875 211110001463 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 211110001464 Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_d; cd04196 211110001465 Probable Catalytic site; other site 211110001466 ribonucleotide-diphosphate reductase subunit beta; Provisional; Region: nrdF2; PRK13966 211110001467 Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049 211110001468 dimer interface [polypeptide binding]; other site 211110001469 putative radical transfer pathway; other site 211110001470 diiron center [ion binding]; other site 211110001471 tyrosyl radical; other site 211110001472 ribonucleotide reductase stimulatory protein; Reviewed; Region: nrdI; PRK03600 211110001473 ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK07187 211110001474 Ribonucleotide reductase N-terminal; Region: RNR_N; pfam08343 211110001475 Class I ribonucleotide reductase; Region: RNR_I; cd01679 211110001476 active site 211110001477 dimer interface [polypeptide binding]; other site 211110001478 catalytic residues [active] 211110001479 effector binding site; other site 211110001480 R2 peptide binding site; other site 211110001481 Leucine rich repeats (6 copies); Region: LRR_5; pfam13306 211110001482 Leucine rich repeats (6 copies); Region: LRR_5; pfam13306 211110001483 Predicted flavin-nucleotide-binding protein structurally related to pyridoxine 5'-phosphate oxidase [General function prediction only]; Region: COG3576 211110001484 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3708 211110001485 Uncharacterized protein conserved in bacteria (DUF2316); Region: DUF2316; pfam10078 211110001486 Uncharacterized homolog of gamma-carboxymuconolactone decarboxylase subunit [Function unknown]; Region: COG0599 211110001487 Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1917 211110001488 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 211110001489 Helix-Turn-Helix DNA binding domain of the MerR-like transcription regulators YyaN and YraB; Region: HTH_YyaN; cd01109 211110001490 DNA binding residues [nucleotide binding] 211110001491 putative dimer interface [polypeptide binding]; other site 211110001492 similar to alcohol dehydrogenase (C-terminal part);unknown 211110001493 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 211110001494 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 211110001495 similar to oxydoreductase (C-terminal part);unknown 211110001496 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 211110001497 catalytic tetrad [active] 211110001498 Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]; Region: CzcD; COG1230 211110001499 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 211110001500 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 211110001501 YSIRK-targeted surface antigen transcriptional regulator; Region: adjacent_YSIRK; TIGR04094 211110001502 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 211110001503 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 211110001504 Gram-positive signal peptide, YSIRK family; Region: YSIRK_signal; TIGR01168 211110001505 Alpha C protein N terminal; Region: AlphaC_N; pfam08829 211110001506 Rib/alpha-like repeat; Region: Rib; cl07159 211110001507 Rib/alpha-like repeat; Region: Rib; cl07159 211110001508 Rib/alpha/Esp surface antigen repeat; Region: rib_alpha; TIGR02331 211110001509 Rib/alpha-like repeat; Region: Rib; pfam08428 211110001510 Rib/alpha-like repeat; Region: Rib; pfam08428 211110001511 Rib/alpha-like repeat; Region: Rib; pfam08428 211110001512 Rib/alpha-like repeat; Region: Rib; pfam08428 211110001513 Rib/alpha-like repeat; Region: Rib; cl07159 211110001514 Gram positive anchor; Region: Gram_pos_anchor; pfam00746 211110001515 RelB antitoxin; Region: RelB; cl01171 211110001516 Domain of unknown function (DUF955); Region: DUF955; pfam06114 211110001517 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 211110001518 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 211110001519 non-specific DNA binding site [nucleotide binding]; other site 211110001520 salt bridge; other site 211110001521 sequence-specific DNA binding site [nucleotide binding]; other site 211110001522 Domain of unknown function (DUF771); Region: DUF771; pfam05595 211110001523 similar to integrase (C-terminal part);unknown 211110001524 Cupin domain; Region: Cupin_2; cl17218 211110001525 Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1917 211110001526 Methyltransferase domain; Region: Methyltransf_31; pfam13847 211110001527 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 211110001528 S-adenosylmethionine binding site [chemical binding]; other site 211110001529 Domain of unknown function (DUF1912); Region: DUF1912; pfam08930 211110001530 hypothetical protein; Provisional; Region: PRK07758 211110001531 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 211110001532 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 211110001533 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 211110001534 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 211110001535 AAA domain; Region: AAA_18; pfam13238 211110001536 AAA domain; Region: AAA_17; pfam13207 211110001537 valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729 211110001538 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 211110001539 active site 211110001540 HIGH motif; other site 211110001541 nucleotide binding site [chemical binding]; other site 211110001542 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 211110001543 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 211110001544 active site 211110001545 KMSKS motif; other site 211110001546 Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962 211110001547 tRNA binding surface [nucleotide binding]; other site 211110001548 anticodon binding site; other site 211110001549 Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458 211110001550 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 211110001551 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 211110001552 CorA-like Mg2+ transporter protein; Region: CorA; pfam01544 211110001553 uncharacterized bacterial subfamily of the Escherichia coli CorA-Salmonella typhimurium ZntB family; Region: EcCorA_ZntB-like_u2; cd12827 211110001554 Cl binding site [ion binding]; other site 211110001555 oligomer interface [polypeptide binding]; other site 211110001556 Protein of unknown function (DUF419); Region: DUF419; pfam04237 211110001557 Asparagine synthetase (aspartate-ammonia ligase) (AsnA) catalyses the conversion of L-aspartate to L-asparagine in the presence of ATP and ammonia. AsnA is a homodimeric enzyme which is structurally similiar to the catalytic core domain of class II...; Region: AsnA; cd00645 211110001558 dimer interface [polypeptide binding]; other site 211110001559 active site 211110001560 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 211110001561 catalytic residues [active] 211110001562 Conserved hypothetical protein 95; Region: Cons_hypoth95; pfam03602 211110001563 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 211110001564 S-adenosylmethionine binding site [chemical binding]; other site 211110001565 phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168 211110001566 Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163 211110001567 active site 211110001568 (T/H)XGH motif; other site 211110001569 Predicted secreted protein containing a PDZ domain [Signal transduction mechanisms]; Region: SdrC; COG3480 211110001570 PDZ domain, also called DHR (Dlg homologous region) or GLGF (after a conserved sequence motif). Many PDZ domains bind C-terminal polypeptides, though binding to internal (non-C-terminal) polypeptides and even to lipids has been demonstrated; Region: PDZ; cl00117 211110001571 protein binding site [polypeptide binding]; other site 211110001572 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 211110001573 Escherichia coli UshA-like family, N-terminal metallophosphatase domain; Region: MPP_UshA_N_like; cd00845 211110001574 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 211110001575 active site 211110001576 metal binding site [ion binding]; metal-binding site 211110001577 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 211110001578 Protein of unknown function (DUF1027); Region: DUF1027; cl09961 211110001579 ribosomal RNA large subunit methyltransferase N; Provisional; Region: PRK14455 211110001580 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 211110001581 FeS/SAM binding site; other site 211110001582 VanZ like family; Region: VanZ; pfam04892 211110001583 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 211110001584 putative multidrug transporter membrane\ATP-binding components; Provisional; Region: PRK10789 211110001585 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 211110001586 Walker A/P-loop; other site 211110001587 ATP binding site [chemical binding]; other site 211110001588 Q-loop/lid; other site 211110001589 ABC transporter signature motif; other site 211110001590 Walker B; other site 211110001591 D-loop; other site 211110001592 H-loop/switch region; other site 211110001593 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 211110001594 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 211110001595 ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254 211110001596 Walker A/P-loop; other site 211110001597 ATP binding site [chemical binding]; other site 211110001598 Q-loop/lid; other site 211110001599 ABC transporter signature motif; other site 211110001600 Walker B; other site 211110001601 D-loop; other site 211110001602 H-loop/switch region; other site 211110001603 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 211110001604 Glutamine amidotransferase class-I; Region: GATase; pfam00117 211110001605 glutamine binding [chemical binding]; other site 211110001606 catalytic triad [active] 211110001607 Uncharacterized conserved protein [General function prediction only]; Region: BioY; COG1268 211110001608 biotin synthase; Region: bioB; TIGR00433 211110001609 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 211110001610 FeS/SAM binding site; other site 211110001611 Biotin and Thiamin Synthesis associated domain; Region: BATS; pfam06968 211110001612 Similar to Acetyl-COA acetyltransferase (truncated);Unknown 211110001613 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 211110001614 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 211110001615 active site 211110001616 CoA binding site [chemical binding]; other site 211110001617 AMP binding site [chemical binding]; other site 211110001618 Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177 211110001619 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 211110001620 minor groove reading motif; other site 211110001621 helix-hairpin-helix signature motif; other site 211110001622 substrate binding pocket [chemical binding]; other site 211110001623 active site 211110001624 Type IV leader peptidase family; Region: Peptidase_A24; pfam01478 211110001625 Bacterial protein of unknown function (DUF910); Region: DUF910; pfam06014 211110001626 ROK family protein (putative glucokinase); Region: ROK_glcA_fam; TIGR00744 211110001627 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 211110001628 nucleotide binding site [chemical binding]; other site 211110001629 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 211110001630 active site residue [active] 211110001631 Predicted membrane GTPase involved in stress response [Signal transduction mechanisms]; Region: TypA; COG1217 211110001632 Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891 211110001633 G1 box; other site 211110001634 putative GEF interaction site [polypeptide binding]; other site 211110001635 GTP/Mg2+ binding site [chemical binding]; other site 211110001636 Switch I region; other site 211110001637 G2 box; other site 211110001638 G3 box; other site 211110001639 Switch II region; other site 211110001640 G4 box; other site 211110001641 G5 box; other site 211110001642 BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu. BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691 211110001643 BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants. BipA is a highly...; Region: BipA_TypA_C; cd03710 211110001644 Protein of unknown function (DUF3165); Region: DUF3165; pfam11364 211110001645 UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK02472 211110001646 Alanine dehydrogenase/PNT, C-terminal domain; Region: AlaDh_PNT_C; smart01002 211110001647 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 211110001648 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 211110001649 undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726 211110001650 MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785 211110001651 homodimer interface [polypeptide binding]; other site 211110001652 active site 211110001653 POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478 211110001654 Cell division protein FtsQ; Region: FtsQ; pfam03799 211110001655 Cell division ATPase FtsA [Cell division and chromosome partitioning]; Region: ftsA; COG0849 211110001656 Cell division protein FtsA; Region: FtsA; smart00842 211110001657 Cell division protein FtsA; Region: FtsA; pfam14450 211110001658 Domain of unknown function (DUF3484); Region: DUF3484; pfam11983 211110001659 cell division protein FtsZ; Validated; Region: PRK09330 211110001660 FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes. FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201 211110001661 nucleotide binding site [chemical binding]; other site 211110001662 SulA interaction site; other site 211110001663 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, YBL036c-like proteins; Region: PLPDE_III_YBL036c_like; cd00635 211110001664 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 211110001665 catalytic residue [active] 211110001666 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1799 211110001667 YGGT family; Region: YGGT; pfam02325 211110001668 Uncharacterized conserved protein, contains S4-like domain [Function unknown]; Region: COG2302 211110001669 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 211110001670 RNA binding surface [nucleotide binding]; other site 211110001671 DivIVA protein; Region: DivIVA; pfam05103 211110001672 DivIVA domain; Region: DivI1A_domain; TIGR03544 211110001673 isoleucyl-tRNA synthetase; Provisional; Region: ileS; PRK13804 211110001674 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 211110001675 active site 211110001676 HIGH motif; other site 211110001677 nucleotide binding site [chemical binding]; other site 211110001678 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 211110001679 active site 211110001680 KMSKS motif; other site 211110001681 Anticodon-binding domain of bacterial and eukaryotic mitochondrial isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_BEm; cd07960 211110001682 tRNA binding surface [nucleotide binding]; other site 211110001683 anticodon binding site; other site 211110001684 Domain of unknown function (DUF1827); Region: DUF1827; pfam08860 211110001685 Contains a crystal structure of the Nudix hydrolase from Enterococcus faecalis, which has an unknown function. In general, members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes...; Region: Nudix_Hydrolase_25; cd04684 211110001686 nudix motif; other site 211110001687 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 211110001688 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 211110001689 Walker A motif; other site 211110001690 ATP binding site [chemical binding]; other site 211110001691 Walker B motif; other site 211110001692 arginine finger; other site 211110001693 UvrB/uvrC motif; Region: UVR; pfam02151 211110001694 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 211110001695 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 211110001696 Walker A motif; other site 211110001697 ATP binding site [chemical binding]; other site 211110001698 Walker B motif; other site 211110001699 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 211110001700 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4703 211110001701 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 211110001702 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 211110001703 dimer interface [polypeptide binding]; other site 211110001704 conserved gate region; other site 211110001705 putative PBP binding loops; other site 211110001706 ABC-ATPase subunit interface; other site 211110001707 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 211110001708 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 211110001709 Walker A/P-loop; other site 211110001710 ATP binding site [chemical binding]; other site 211110001711 Q-loop/lid; other site 211110001712 ABC transporter signature motif; other site 211110001713 Walker B; other site 211110001714 D-loop; other site 211110001715 H-loop/switch region; other site 211110001716 phosphoglucomutase-2-like protein; Provisional; Region: PTZ00150 211110001717 This CD includes PGM2 (phosphoglucomutase 2) and PGM2L1 (phosphoglucomutase 2-like 1). The mammalian PGM2 is thought to be a phosphopentomutase that catalyzes the conversion of the nucleoside breakdown products, ribose-1-phosphate and...; Region: PGM2; cd05799 211110001718 active site 211110001719 substrate binding site [chemical binding]; other site 211110001720 metal binding site [ion binding]; metal-binding site 211110001721 bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK14179 211110001722 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763 211110001723 NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080 211110001724 homodimer interface [polypeptide binding]; other site 211110001725 NADP binding site [chemical binding]; other site 211110001726 substrate binding site [chemical binding]; other site 211110001727 B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171 211110001728 putative substrate binding site [chemical binding]; other site 211110001729 putative ATP binding site [chemical binding]; other site 211110001730 exodeoxyribonuclease VII large subunit; Reviewed; Region: xseA; PRK00286 211110001731 ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489 211110001732 generic binding surface II; other site 211110001733 generic binding surface I; other site 211110001734 exodeoxyribonuclease VII small subunit; Provisional; Region: PRK00977 211110001735 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 211110001736 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 211110001737 substrate binding pocket [chemical binding]; other site 211110001738 chain length determination region; other site 211110001739 substrate-Mg2+ binding site; other site 211110001740 catalytic residues [active] 211110001741 aspartate-rich region 1; other site 211110001742 active site lid residues [active] 211110001743 aspartate-rich region 2; other site 211110001744 Predicted rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: COG1189 211110001745 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 211110001746 RNA binding surface [nucleotide binding]; other site 211110001747 FtsJ-like methyltransferase; Region: FtsJ; pfam01728 211110001748 Arginine repressor [Transcription]; Region: ArgR; COG1438 211110001749 Arginine repressor, DNA binding domain; Region: Arg_repressor; pfam01316 211110001750 Arginine repressor, C-terminal domain; Region: Arg_repressor_C; pfam02863 211110001751 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: RecN; COG0497 211110001752 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 211110001753 Walker A/P-loop; other site 211110001754 ATP binding site [chemical binding]; other site 211110001755 Q-loop/lid; other site 211110001756 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 211110001757 ABC transporter signature motif; other site 211110001758 Walker B; other site 211110001759 D-loop; other site 211110001760 H-loop/switch region; other site 211110001761 EDD domain protein, DegV family; Region: DegV; TIGR00762 211110001762 Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645 211110001763 Members of the SGNH-hydrolase superfamily, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase_YpmR_like; cd04506 211110001764 active site 211110001765 catalytic triad [active] 211110001766 oxyanion hole [active] 211110001767 Uncharacterized protein conserved in bacteria (DUF2140); Region: DUF2140; pfam09911 211110001768 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 211110001769 IHF dimer interface [polypeptide binding]; other site 211110001770 IHF - DNA interface [nucleotide binding]; other site 211110001771 dihydroorotate dehydrogenase (subfamily 1) family protein; Region: pyrD_sub1_fam; TIGR01037 211110001772 Dihydroorotate dehydrogenase (DHOD) class 1A FMN-binding domain. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine...; Region: DHOD_1A_like; cd04741 211110001773 active site 211110001774 FMN binding site [chemical binding]; other site 211110001775 substrate binding site [chemical binding]; other site 211110001776 catalytic residues [active] 211110001777 homodimer interface [polypeptide binding]; other site 211110001778 FemAB family; Region: FemAB; pfam02388 211110001779 FemAB family; Region: FemAB; pfam02388 211110001780 FemAB family; Region: FemAB; pfam02388 211110001781 Acetyltransferase (GNAT) domain; Region: Acetyltransf_6; pfam13480 211110001782 sugar phosphate phosphatase; Provisional; Region: PRK10513 211110001783 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 211110001784 active site 211110001785 motif I; other site 211110001786 motif II; other site 211110001787 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cl17915 211110001788 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 211110001789 HD superfamily phosphohydrolases [General function prediction only]; Region: COG1078 211110001790 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 211110001791 Zn2+ binding site [ion binding]; other site 211110001792 Mg2+ binding site [ion binding]; other site 211110001793 Domain of unknown function (DUF1934); Region: DUF1934; pfam09148 211110001794 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; pfam00690 211110001795 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 211110001796 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 211110001797 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 211110001798 haloacid dehalogenase-like hydrolase; Region: HAD; pfam12710 211110001799 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 211110001800 putative phosphoesterase; Region: acc_ester; TIGR03729 211110001801 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 211110001802 Firmicute fructose-1,6-bisphosphatase; Region: FBPase_2; pfam06874 211110001803 epoxyqueuosine reductase; Region: TIGR00276 211110001804 Domain of unknown function (DUF1730); Region: DUF1730; pfam08331 211110001805 peptide chain release factor 2; Validated; Region: prfB; PRK00578 211110001806 This domain is found in peptide chain release factors; Region: PCRF; smart00937 211110001807 RF-1 domain; Region: RF-1; pfam00472 211110001808 Predicted ATPase involved in cell division [Cell division and chromosome partitioning]; Region: FtsE; COG2884 211110001809 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 211110001810 Walker A/P-loop; other site 211110001811 ATP binding site [chemical binding]; other site 211110001812 Q-loop/lid; other site 211110001813 ABC transporter signature motif; other site 211110001814 Walker B; other site 211110001815 D-loop; other site 211110001816 H-loop/switch region; other site 211110001817 Cell division protein [Cell division and chromosome partitioning]; Region: FtsX; COG2177 211110001818 cell division ABC transporter subunit FtsX; Provisional; Region: ftsX; PRK11026 211110001819 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 211110001820 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 211110001821 acetoin reductase; Validated; Region: PRK08643 211110001822 meso-2,3-butanediol dehydrogenase-like, classical (c) SDRs; Region: meso-BDH-like_SDR_c; cd05366 211110001823 NAD binding site [chemical binding]; other site 211110001824 homotetramer interface [polypeptide binding]; other site 211110001825 homodimer interface [polypeptide binding]; other site 211110001826 active site 211110001827 substrate binding site [chemical binding]; other site 211110001828 bifunctional ATP-dependent DNA helicase/DNA polymerase III subunit epsilon; Validated; Region: PRK07246 211110001829 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 211110001830 active site 211110001831 catalytic site [active] 211110001832 substrate binding site [chemical binding]; other site 211110001833 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 211110001834 ATP binding site [chemical binding]; other site 211110001835 Helicase C-terminal domain; Region: Helicase_C_2; pfam13307 211110001836 aspartate aminotransferase; Provisional; Region: PRK05764 211110001837 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 211110001838 pyridoxal 5'-phosphate binding site [chemical binding]; other site 211110001839 homodimer interface [polypeptide binding]; other site 211110001840 catalytic residue [active] 211110001841 asparaginyl-tRNA synthetase; Validated; Region: asnC; PRK03932 211110001842 AsnRS_cyto_like_N: N-terminal, anticodon recognition domain of the type found in human and Saccharomyces cerevisiae cytoplasmic asparaginyl-tRNA synthetase (AsnRS), in Brugia malayai AsnRs and, in various putative bacterial AsnRSs. This domain is a...; Region: AsnRS_cyto_like_N; cd04323 211110001843 putative dimer interface [polypeptide binding]; other site 211110001844 putative anticodon binding site; other site 211110001845 Asx tRNA synthetase (AspRS/AsnRS) class II core domain. Assignment to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs in the core domain. This family includes AsnRS as well as...; Region: AsxRS_core; cd00776 211110001846 homodimer interface [polypeptide binding]; other site 211110001847 motif 1; other site 211110001848 motif 2; other site 211110001849 active site 211110001850 motif 3; other site 211110001851 NH_3: A subgroup of nucleoside hydrolases. This group contains eukaryotic and bacterial proteins similar to nucleoside hydrolases. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the respective base. These enzymes...; Region: nuc_hydro_3; cd02653 211110001852 active site 211110001853 OsmC-like protein; Region: OsmC; cl00767 211110001854 glmZ(sRNA)-inactivating NTPase; Provisional; Region: PRK05416 211110001855 conserved hypothetical protein, cofD-related; Region: CofD_related; TIGR01826 211110001856 Family of CofD-like proteins and proteins related to YvcK; Region: CofD_YvcK; cd07044 211110001857 dimer interface [polypeptide binding]; other site 211110001858 phosphate binding site [ion binding]; other site 211110001859 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1481 211110001860 Sporulation Regulator WhiA N terminal; Region: WhiA_N; pfam10298 211110001861 Peptidase family C69; Region: Peptidase_C69; pfam03577 211110001862 ABC-type metal ion transport system, periplasmic component/surface adhesin [Inorganic ion transport and metabolism]; Region: LraI; COG0803 211110001863 Metal binding protein AcdA. These proteins have been shown to function in the ABC uptake of Zn2+ and Mn2+ and in competence for genetic transformation and adhesion. The AcdA proteins belong to the TroA superfamily of helical backbone metal receptor...; Region: AdcA; cd01017 211110001864 metal binding site [ion binding]; metal-binding site 211110001865 YodA lipocalin-like domain; Region: YodA; pfam09223 211110001866 50S ribosomal protein L31 type B; Reviewed; Region: rpmE2; PRK01678 211110001867 Exopolyphosphatase-related proteins [General function prediction only]; Region: COG0618 211110001868 DHH family; Region: DHH; pfam01368 211110001869 DHHA1 domain; Region: DHHA1; pfam02272 211110001870 Adenosine deaminase (ADA) is a monomeric zinc dependent enzyme which catalyzes the irreversible hydrolytic deamination of both adenosine, as well as desoxyadenosine, to ammonia and inosine or desoxyinosine, respectively. ADA plays an important role in...; Region: ADA; cd01320 211110001871 Adenosine deaminase [Nucleotide transport and metabolism]; Region: Add; COG1816 211110001872 active site 211110001873 purine riboside binding site [chemical binding]; other site 211110001874 flavodoxin; Validated; Region: PRK07308 211110001875 hypothetical protein; Provisional; Region: PRK07248 211110001876 Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038 211110001877 ClC sycA-like chloride channel proteins. This ClC family presents in bacteria, where it facilitates acid resistance in acidic soil. Mutation of this gene (sycA) in Rhizobium tropici CIAT899 causes serious deficiencies in nodule development, nodulation...; Region: ClC_sycA_like; cd03682 211110001878 putative Cl- selectivity filter; other site 211110001879 putative pore gating glutamate residue; other site 211110001880 50S ribosomal protein L19; Provisional; Region: rplS; PRK05338 211110001881 similar to integrase C-terminal part (truncated);unknown 211110001882 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 211110001883 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 211110001884 Helix-turn-helix domain; Region: HTH_28; pfam13518 211110001885 similar to transposase;unknown 211110001886 similar to transposase;unknown 211110001887 similar to transposase;unknown 211110001888 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 211110001889 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 211110001890 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 211110001891 Walker A/P-loop; other site 211110001892 ATP binding site [chemical binding]; other site 211110001893 Q-loop/lid; other site 211110001894 ABC transporter signature motif; other site 211110001895 Walker B; other site 211110001896 D-loop; other site 211110001897 H-loop/switch region; other site 211110001898 ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]; Region: LolE; COG4591 211110001899 FtsX-like permease family; Region: FtsX; pfam02687 211110001900 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 211110001901 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 211110001902 active site 211110001903 phosphorylation site [posttranslational modification] 211110001904 intermolecular recognition site; other site 211110001905 dimerization interface [polypeptide binding]; other site 211110001906 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 211110001907 DNA binding site [nucleotide binding] 211110001908 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 211110001909 dimerization interface [polypeptide binding]; other site 211110001910 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 211110001911 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 211110001912 dimer interface [polypeptide binding]; other site 211110001913 phosphorylation site [posttranslational modification] 211110001914 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 211110001915 ATP binding site [chemical binding]; other site 211110001916 Mg2+ binding site [ion binding]; other site 211110001917 G-X-G motif; other site 211110001918 Similar to transposase C-terminal end (truncated);Unknown 211110001919 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3237 211110001920 rod shape-determining protein RodA; Region: rodA_shape; TIGR02210 211110001921 haloacid dehalogenase superfamily, subfamily IA, variant 1 with third motif having Dx(3-4)D or Dx(3-4)E; Region: HAD-SF-IA-v1; TIGR01549 211110001922 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 211110001923 motif II; other site 211110001924 DNA gyrase subunit B; Validated; Region: gyrB; PRK05644 211110001925 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 211110001926 Mg2+ binding site [ion binding]; other site 211110001927 G-X-G motif; other site 211110001928 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 211110001929 anchoring element; other site 211110001930 dimer interface [polypeptide binding]; other site 211110001931 ATP binding site [chemical binding]; other site 211110001932 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 211110001933 active site 211110001934 putative metal-binding site [ion binding]; other site 211110001935 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 211110001936 septation ring formation regulator EzrA; Provisional; Region: PRK04778 211110001937 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 211110001938 phosphoserine phosphatase SerB; Region: serB; TIGR00338 211110001939 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 211110001940 motif II; other site 211110001941 NUDIX domain; Region: NUDIX; pfam00293 211110001942 nudix motif; other site 211110001943 Protein of unknown function (DUF1694); Region: DUF1694; pfam07997 211110001944 enolase; Provisional; Region: eno; PRK00077 211110001945 Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313 211110001946 dimer interface [polypeptide binding]; other site 211110001947 metal binding site [ion binding]; metal-binding site 211110001948 substrate binding pocket [chemical binding]; other site 211110001949 DNA/RNA non-specific endonuclease; Region: Endonuclea_NS_2; cl17626 211110001950 DNA/RNA non-specific endonuclease; Region: Endonuclease_NS; smart00892 211110001951 3-phosphoshikimate 1-carboxyvinyltransferase; Provisional; Region: PRK02427 211110001952 EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556 211110001953 hinge; other site 211110001954 active site 211110001955 shikimate kinase; Reviewed; Region: aroK; PRK00131 211110001956 Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464 211110001957 ADP binding site [chemical binding]; other site 211110001958 magnesium binding site [ion binding]; other site 211110001959 putative shikimate binding site; other site 211110001960 Transcriptional regulator [Transcription]; Region: LytR; COG1316 211110001961 SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase [Translation, ribosomal structure and biogenesis]; Region: TrmA; COG2265 211110001962 TRAM domain; Region: TRAM; cl01282 211110001963 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 211110001964 S-adenosylmethionine binding site [chemical binding]; other site 211110001965 Domain of unknown function (DUF3332); Region: DUF3332; pfam11810 211110001966 acid phosphatase/phosphotransferase; Provisional; Region: aphA; PRK11009 211110001967 Protein of unknown function (DUF1706); Region: DUF1706; pfam08020 211110001968 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 211110001969 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 211110001970 YSIRK type signal peptide; Region: YSIRK_signal; pfam04650 211110001971 similar to transposase, truncated.;unknown 211110001972 Transposase; Region: HTH_Tnp_1; pfam01527 211110001973 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 211110001975 Unknown 211110001976 Heat shock protein 33 (Hsp33): Cytosolic protein that acts as a molecular chaperone under oxidative conditions. In normal (reducing) cytosolic conditions, four conserved Cys residues are coordinated by a Zn ion. Under oxidative stress (such as heat...; Region: Hsp33; cl00236 211110001977 similar to transcriptional regulator (C-terminal part);unknown 211110001978 YSIRK-targeted surface antigen transcriptional regulator; Region: adjacent_YSIRK; TIGR04094 211110001979 fimbrial isopeptide formation D2 domain; Region: RrgB_K2N_iso_D2; TIGR04226 211110001980 Cna protein B-type domain; Region: Cna_B; pfam05738 211110001981 Sortase C (SrtC) or subfamily-3 sortases are membrane cysteine transpeptidases found in Gram-positive bacteria that anchor surface proteins to peptidoglycans of the bacterial cell wall envelope. This involves a transpeptidation reaction in which the...; Region: Sortase_C_3; cd05827 211110001982 active site 211110001983 catalytic site [active] 211110001984 Sortase C (SrtC) or subfamily-3 sortases are membrane cysteine transpeptidases found in Gram-positive bacteria that anchor surface proteins to peptidoglycans of the bacterial cell wall envelope. This involves a transpeptidation reaction in which the...; Region: Sortase_C_3; cd05827 211110001985 active site 211110001986 catalytic site [active] 211110001987 Cna protein B-type domain; Region: Cna_B; pfam05738 211110001988 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 211110001989 metal ion-dependent adhesion site (MIDAS); other site 211110001990 Cna protein B-type domain; Region: Cna_B; pfam05738 211110001991 similar to hypothetical sortase protein (N-terminal part);Unknown 211110001992 similar to surface protein (sortase);unknown 211110001993 similar to transposase;unknown 211110001994 Cna protein B-type domain; Region: Cna_B; pfam05738 211110001995 similar to unknown proteins;unknown 211110001996 Beta-lactamase; Region: Beta-lactamase; pfam00144 211110001997 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 211110001998 ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: COG4586 211110001999 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 211110002000 Walker A/P-loop; other site 211110002001 ATP binding site [chemical binding]; other site 211110002002 Q-loop/lid; other site 211110002003 ABC transporter signature motif; other site 211110002004 Walker B; other site 211110002005 D-loop; other site 211110002006 H-loop/switch region; other site 211110002007 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4587 211110002008 ABC-2 family transporter protein; Region: ABC2_membrane_6; cl01496 211110002009 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG3694 211110002010 Acyl transferase domain; Region: Acyl_transf_1; cl08282 211110002011 3-oxoacyl-(acyl-carrier-protein) reductase; Region: 3oxo_ACP_reduc; TIGR01830 211110002012 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 211110002013 NAD(P) binding site [chemical binding]; other site 211110002014 active site 211110002015 Phosphopantetheine attachment site; Region: PP-binding; cl09936 211110002016 FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288 211110002017 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 211110002018 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 211110002019 Walker A/P-loop; other site 211110002020 ATP binding site [chemical binding]; other site 211110002021 Q-loop/lid; other site 211110002022 ABC transporter signature motif; other site 211110002023 Walker B; other site 211110002024 D-loop; other site 211110002025 H-loop/switch region; other site 211110002026 ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698 211110002027 Aminomethyltransferase folate-binding domain; Region: GCV_T; pfam01571 211110002028 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 211110002029 3-oxoacyl-(acyl carrier protein) synthase II; Provisional; Region: PRK14691 211110002030 dimer interface [polypeptide binding]; other site 211110002031 active site 211110002032 Condensing enzymes; Family of enzymes that catalyze a (decarboxylating or non-decarboxylating) Claisen-like condensation reaction. Members are share strong structural similarity, and are involved in the synthesis and degradation of fatty acids, and the...; Region: cond_enzymes; cl09938 211110002033 Glycosyl transferases, related to UDP-glucuronosyltransferase [Carbohydrate transport and metabolism / Signal transduction mechanisms]; Region: COG1819 211110002034 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 211110002035 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 211110002036 Similar to ABC transporter (permease) (C-terminal part);unknown 211110002037 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 211110002038 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 211110002039 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 211110002040 Walker A/P-loop; other site 211110002041 ATP binding site [chemical binding]; other site 211110002042 Q-loop/lid; other site 211110002043 ABC transporter signature motif; other site 211110002044 Walker B; other site 211110002045 D-loop; other site 211110002046 H-loop/switch region; other site 211110002047 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4529 211110002048 FAD-NAD(P)-binding; Region: NAD_binding_9; pfam13454 211110002049 DNA/RNA non-specific endonuclease; Region: Endonuclea_NS_2; cl17626 211110002050 DNA/RNA non-specific endonuclease; Region: Endonuclease_NS; smart00892 211110002051 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 211110002052 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 211110002053 ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: COG4619 211110002054 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 211110002055 Walker A/P-loop; other site 211110002056 ATP binding site [chemical binding]; other site 211110002057 Q-loop/lid; other site 211110002058 ABC transporter signature motif; other site 211110002059 Walker B; other site 211110002060 D-loop; other site 211110002061 H-loop/switch region; other site 211110002062 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG0390 211110002063 Transcriptional regulator [Transcription]; Region: LysR; COG0583 211110002064 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 211110002065 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 211110002066 dimerization interface [polypeptide binding]; other site 211110002067 Predicted membrane protein, putative toxin regulator [General function prediction only]; Region: PfoR; COG3641 211110002068 Phosphotransferase system, EIIC; Region: PTS_EIIC_2; pfam13303 211110002069 D-Lactate dehydrogenase and D-2-Hydroxyisocaproic acid dehydrogenase (D-HicDH), NAD-binding and catalytic domains; Region: LDH; cd12186 211110002070 D-lactate dehydrogenase; Validated; Region: PRK08605 211110002071 homodimer interface [polypeptide binding]; other site 211110002072 ligand binding site [chemical binding]; other site 211110002073 NAD binding site [chemical binding]; other site 211110002074 catalytic site [active] 211110002075 MFS/sugar transport protein; Region: MFS_2; pfam13347 211110002076 melibiose:sodium symporter; Provisional; Region: PRK10429; cl15392 211110002077 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 211110002078 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166 211110002079 substrate binding site [chemical binding]; other site 211110002080 ATP binding site [chemical binding]; other site 211110002081 beta-D-glucuronidase; Provisional; Region: PRK10150 211110002082 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837 211110002083 Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703 211110002084 Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836 211110002085 Transcriptional regulators [Transcription]; Region: FadR; COG2186 211110002086 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 211110002087 DNA-binding site [nucleotide binding]; DNA binding site 211110002088 FCD domain; Region: FCD; pfam07729 211110002089 2-keto-3-deoxy-6-phosphogluconate aldolase [Carbohydrate transport and metabolism]; Region: Eda; COG0800 211110002090 KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452 211110002091 active site 211110002092 intersubunit interface [polypeptide binding]; other site 211110002093 catalytic residue [active] 211110002094 Glucuronate isomerase; Region: UxaC; pfam02614 211110002095 Glucuronate isomerase [Carbohydrate transport and metabolism]; Region: UxaC; COG1904 211110002096 mannonate dehydratase; Provisional; Region: PRK03906 211110002097 mannonate dehydratase; Region: uxuA; TIGR00695 211110002098 D-mannonate oxidoreductase; Provisional; Region: PRK08277 211110002099 putative D-mannonate oxidoreductase, classical (c) SDR; Region: mannonate_red_SDR_c; cd08935 211110002100 putative NAD(P) binding site [chemical binding]; other site 211110002101 active site 211110002102 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 211110002103 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 211110002104 motif II; other site 211110002105 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 211110002106 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; cl07971 211110002107 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 211110002108 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 211110002109 Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092 211110002110 active site 211110002111 catabolite control protein A; Region: ccpA; TIGR01481 211110002112 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 211110002113 DNA binding site [nucleotide binding] 211110002114 domain linker motif; other site 211110002115 Ligand-binding domain of the catabolite control protein A (CcpA), which functions as the major transcriptional regulator of carbon catabolite repression/regulation; Region: PBP1_CcpA_like; cd06298 211110002116 dimerization interface [polypeptide binding]; other site 211110002117 effector binding site; other site 211110002118 cytoplasmic alpha-amylase; Reviewed; Region: PRK09441 211110002119 Alpha amylase catalytic domain found in bacterial and fungal Alpha amylases (also called 1,4-alpha-D-glucan-4-glucanohydrolase); Region: AmyAc_bac_fung_AmyA; cd11318 211110002120 active site 211110002121 Na/Ca binding site [ion binding]; other site 211110002122 catalytic site [active] 211110002123 Domain of unknown function (DUF1939); Region: DUF1939; pfam09154 211110002124 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 211110002125 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 211110002126 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 211110002127 This family is most closely related to the GT1 family of glycosyltransferases. UDP-glucose-diacylglycerol glucosyltransferase (UGDG; also known as 1,2-diacylglycerol 3-glucosyltransferase) catalyzes the transfer of glucose from UDP-glucose to 1; Region: GT1_UGDG_like; cd03817 211110002128 putative ADP-binding pocket [chemical binding]; other site 211110002129 threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK00413 211110002130 TGS _ThrRS_N: ThrRS (threonyl-tRNA Synthetase) is a class II tRNA synthetase that couples threonine to its cognate tRNA. In addition to its catalytic and anticodon-binding domains, ThrRS has an N-terminal TGS domain, named after the ThrRS, GTPase, and...; Region: TGS_ThrRS_N; cd01667 211110002131 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 211110002132 Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771 211110002133 active site 211110002134 dimer interface [polypeptide binding]; other site 211110002135 motif 1; other site 211110002136 motif 2; other site 211110002137 motif 3; other site 211110002138 ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860 211110002139 anticodon binding site; other site 211110002140 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 211110002141 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 211110002142 active site 211110002143 phosphorylation site [posttranslational modification] 211110002144 intermolecular recognition site; other site 211110002145 dimerization interface [polypeptide binding]; other site 211110002146 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 211110002147 DNA binding site [nucleotide binding] 211110002148 Protein of unknown function (DUF3114); Region: DUF3114; pfam11311 211110002149 Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413 211110002150 Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413 211110002151 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 211110002152 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 211110002153 dimer interface [polypeptide binding]; other site 211110002154 conserved gate region; other site 211110002155 putative PBP binding loops; other site 211110002156 ABC-ATPase subunit interface; other site 211110002157 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 211110002158 dimer interface [polypeptide binding]; other site 211110002159 conserved gate region; other site 211110002160 putative PBP binding loops; other site 211110002161 ABC-ATPase subunit interface; other site 211110002162 bifunctional adhesin/ABC transporter aspartate/glutamate-binding protein; Reviewed; Region: PRK11917 211110002163 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 211110002164 substrate binding pocket [chemical binding]; other site 211110002165 membrane-bound complex binding site; other site 211110002166 hinge residues; other site 211110002167 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 211110002168 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 211110002169 Walker A/P-loop; other site 211110002170 ATP binding site [chemical binding]; other site 211110002171 Q-loop/lid; other site 211110002172 ABC transporter signature motif; other site 211110002173 Walker B; other site 211110002174 D-loop; other site 211110002175 H-loop/switch region; other site 211110002176 Primase C terminal 1 (PriCT-1); Region: PriCT_1; pfam08708 211110002177 Glutaredoxin-like domain (DUF836); Region: DUF836; cl17650 211110002178 Chromosome segregation ATPases [Cell division and chromosome partitioning]; Region: Smc; COG1196 211110002179 Transcriptional regulatory protein LGE1; Region: Lge1; pfam11488 211110002180 DNA/RNA non-specific endonuclease; Region: Endonuclea_NS_2; cl17626 211110002181 DNA/RNA non-specific endonuclease; Region: Endonuclease_NS; smart00892 211110002182 Protein of unknown function (DUF3991); Region: DUF3991; pfam13154 211110002183 Domain of unknown function (DUF955); Region: DUF955; pfam06114 211110002184 DNA topoisomerase III; Provisional; Region: PRK07726 211110002185 TOPRIM_TopoIA_TopoIII: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to topoisomerase III. Type IA DNA topoisomerases remove (relax) negative supercoils in the DNA by: cleaving...; Region: TOPRIM_TopoIA_TopoIII; cd03362 211110002186 active site 211110002187 putative interdomain interaction site [polypeptide binding]; other site 211110002188 putative metal-binding site [ion binding]; other site 211110002189 putative nucleotide binding site [chemical binding]; other site 211110002190 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 211110002191 domain I; other site 211110002192 DNA binding groove [nucleotide binding] 211110002193 phosphate binding site [ion binding]; other site 211110002194 domain II; other site 211110002195 domain III; other site 211110002196 nucleotide binding site [chemical binding]; other site 211110002197 catalytic site [active] 211110002198 domain IV; other site 211110002199 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 211110002200 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 211110002201 Walker A motif; other site 211110002202 ATP binding site [chemical binding]; other site 211110002203 Walker B motif; other site 211110002204 arginine finger; other site 211110002205 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 211110002206 Walker A motif; other site 211110002207 ATP binding site [chemical binding]; other site 211110002208 Walker B motif; other site 211110002209 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 211110002210 A sub-family of peptidase family C39. Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various...; Region: Peptidase_C39A; cd02549 211110002211 putative active site [active] 211110002212 LPXTG-motif cell wall anchor domain; Region: LPXTG_anchor; TIGR01167 211110002213 putative cross-wall-targeting lipoprotein signal; Region: strep_RK_lipo; TIGR03726 211110002214 Membrane protein involved in colicin uptake [Cell envelope biogenesis, outer membrane]; Region: TolA; COG3064 211110002215 adhesin isopeptide-forming domain, sspB-C2 type; Region: isopep_sspB_C2; TIGR04228 211110002216 LPXTG-motif cell wall anchor domain; Region: LPXTG_anchor; TIGR01167 211110002217 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 211110002218 dimer interface [polypeptide binding]; other site 211110002219 ssDNA binding site [nucleotide binding]; other site 211110002220 tetramer (dimer of dimers) interface [polypeptide binding]; other site 211110002221 kinesin-12 family protein; Provisional; Region: PLN03188 211110002222 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 211110002223 Walker A motif; other site 211110002224 ATP binding site [chemical binding]; other site 211110002225 Type IV secretory pathway, VirD4 components [Intracellular trafficking and secretion]; Region: VirD4; COG3505 211110002226 TraM recognition site of TraD and TraG; Region: TraG-D_C; pfam12696 211110002227 conjugal transfer protein TrbL; Provisional; Region: PRK13875 211110002228 DNA polymerase III subunit epsilon; Validated; Region: PRK06195 211110002229 Lantibiotic dehydratase, C terminus; Region: Lant_dehyd_C; pfam04738 211110002230 AAA-like domain; Region: AAA_10; pfam12846 211110002231 Ribosomal protein L6e; Region: Ribosomal_L6e; pfam01159 211110002232 Mannosyl-glycoprotein endo-beta-N-acetylglucosaminidase; Region: Glucosaminidase; pfam01832 211110002233 CHAP domain; Region: CHAP; cl17642 211110002234 Antiactivator of flagellar biosynthesis FleN, an ATPase [Cell motility]; Region: flhG; COG0455 211110002235 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 211110002236 Replication initiator protein A (RepA) N-terminus; Region: RepA_N; pfam06970 211110002237 MarR family; Region: MarR_2; cl17246 211110002238 Uncharacterized protein family (UPF0236); Region: UPF0236; pfam06782 211110002239 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 211110002240 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 211110002241 active site 211110002242 phosphorylation site [posttranslational modification] 211110002243 intermolecular recognition site; other site 211110002244 dimerization interface [polypeptide binding]; other site 211110002245 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 211110002246 DNA binding site [nucleotide binding] 211110002247 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 211110002248 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 211110002249 putative active site [active] 211110002250 heme pocket [chemical binding]; other site 211110002251 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 211110002252 dimer interface [polypeptide binding]; other site 211110002253 phosphorylation site [posttranslational modification] 211110002254 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 211110002255 ATP binding site [chemical binding]; other site 211110002256 Mg2+ binding site [ion binding]; other site 211110002257 G-X-G motif; other site 211110002258 Metal-dependent hydrolases of the beta-lactamase superfamily I [General function prediction only]; Region: PhnP; COG1235 211110002259 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 211110002260 Protein of unknown function (DUF454); Region: DUF454; cl01063 211110002261 ribonuclease III; Reviewed; Region: rnc; PRK00102 211110002262 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 211110002263 dimerization interface [polypeptide binding]; other site 211110002264 active site 211110002265 metal binding site [ion binding]; metal-binding site 211110002266 Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048 211110002267 dsRNA binding site [nucleotide binding]; other site 211110002268 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 211110002269 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 211110002270 Walker A/P-loop; other site 211110002271 ATP binding site [chemical binding]; other site 211110002272 Q-loop/lid; other site 211110002273 SMC proteins Flexible Hinge Domain; Region: SMC_hinge; smart00968 211110002274 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 211110002275 ABC transporter signature motif; other site 211110002276 Walker B; other site 211110002277 D-loop; other site 211110002278 H-loop/switch region; other site 211110002279 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 211110002280 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 211110002281 active site 211110002282 motif I; other site 211110002283 motif II; other site 211110002284 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 211110002285 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 211110002286 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 211110002287 active site 211110002288 motif I; other site 211110002289 motif II; other site 211110002290 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 211110002291 signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416 211110002292 SRP54-type protein, helical bundle domain; Region: SRP54_N; pfam02881 211110002293 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 211110002294 P loop; other site 211110002295 GTP binding site [chemical binding]; other site 211110002296 Predicted membrane protein [Function unknown]; Region: COG3689 211110002297 Predicted permeases [General function prediction only]; Region: COG0701 211110002298 probable oxidoreductase, LLM family; Region: LLM_2I7G; TIGR03858 211110002299 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases [Energy production and conversion]; Region: COG2141 211110002300 Transcriptional accessory protein [Transcription]; Region: Tex; COG2183 211110002301 Tex-like protein N-terminal domain; Region: Tex_N; pfam09371 211110002302 Likely ribonuclease with RNase H fold; Region: YqgFc; smart00732 211110002303 S1_Tex: The C-terminal S1 domain of a transcription accessory factor called Tex, which has been characterized in Bordetella pertussis and Pseudomonas aeruginosa. The tex gene is essential in Bortella pertusis and is named for its role in toxin expression; Region: S1_Tex; cd05685 211110002304 RNA binding site [nucleotide binding]; other site 211110002305 hypothetical protein; Provisional; Region: PRK04351 211110002306 SprT homologues; Region: SprT; cl01182 211110002307 Putative stress-responsive transcriptional regulator [Transcription / Signal transduction mechanisms]; Region: PspC; COG1983 211110002308 HPr kinase/phosphorylase; Provisional; Region: PRK05428 211110002309 HPr Serine kinase N terminus; Region: Hpr_kinase_N; pfam02603 211110002310 HprK/P, the bifunctional histidine-containing protein kinase/phosphatase, controls the phosphorylation state of the phosphocarrier protein HPr and regulates the utilization of carbon sources by gram-positive bacteria. It catalyzes both the ATP-dependent...; Region: HprK_C; cd01918 211110002311 Hpr binding site; other site 211110002312 active site 211110002313 homohexamer subunit interaction site [polypeptide binding]; other site 211110002314 Prolipoprotein diacylglyceryl transferase; Region: LGT; pfam01790 211110002315 Uncharacterized protein containing a divergent version of the methyl-accepting chemotaxis-like domain [General function prediction only]; Region: COG4768 211110002316 YtxH-like protein; Region: YtxH; pfam12732 211110002317 Protein of unknown function (DUF3270); Region: DUF3270; pfam11674 211110002318 Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826 211110002319 Peptidase family U32; Region: Peptidase_U32; pfam01136 211110002320 Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826 211110002321 Members of the ICL/PEPM_KPHMT enzyme superfamily catalyze the formation and cleavage of either P-C or C-C bonds. Typical members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate...; Region: ICL_KPHMT; cl00435 211110002322 Peptidase family U32; Region: Peptidase_U32; pfam01136 211110002323 Uncharacterized protein conserved in bacteria (DUF2128); Region: DUF2128; pfam09901 211110002324 manganese transport protein MntH; Reviewed; Region: PRK00701 211110002325 Natural resistance-associated macrophage protein; Region: Nramp; pfam01566 211110002326 riboflavin biosynthesis protein RibD; Region: eubact_ribD; TIGR00326 211110002327 Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284 211110002328 catalytic motif [active] 211110002329 Zn binding site [ion binding]; other site 211110002330 RibD C-terminal domain; Region: RibD_C; cl17279 211110002331 riboflavin synthase subunit alpha; Provisional; Region: PRK09289 211110002332 Lumazine binding domain; Region: Lum_binding; pfam00677 211110002333 Lumazine binding domain; Region: Lum_binding; pfam00677 211110002334 bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II protein; Provisional; Region: PRK09311 211110002335 3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; pfam00926 211110002336 GTP cyclohydrolase II (RibA). GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641 211110002337 dimerization interface [polypeptide binding]; other site 211110002338 active site 211110002339 lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209 211110002340 homopentamer interface [polypeptide binding]; other site 211110002341 active site 211110002342 lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484 211110002343 LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322 211110002344 dimer interface [polypeptide binding]; other site 211110002345 putative anticodon binding site; other site 211110002346 Lys_tRNA synthetase (LysRS) class II core domain. Class II LysRS is a dimer which attaches a lysine to the 3' OH group of ribose of the appropriate tRNA. Its assignment to class II aaRS is based upon its structure and the presence of three...; Region: LysRS_core; cd00775 211110002347 motif 1; other site 211110002348 active site 211110002349 motif 2; other site 211110002350 motif 3; other site 211110002351 Predicted hydrolase (HAD superfamily) [General function prediction only]; Region: COG1011 211110002352 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 211110002353 motif II; other site 211110002354 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 211110002355 catalytic core [active] 211110002356 This CD includes cysteinyl-tRNA(Pro) deacylases from Haemophilus influenzae and Escherichia coli and other related bacterial proteins. These trans-acting, single-domain proteins are homologs of ProX and also the cis-acting prolyl-tRNA synthetase (ProRS)...; Region: YbaK_deacylase; cd00002 211110002357 putative deacylase active site [active] 211110002358 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 211110002359 NADH(P)-binding; Region: NAD_binding_10; pfam13460 211110002360 NAD(P) binding site [chemical binding]; other site 211110002361 active site 211110002362 Lyzozyme M1 (1,4-beta-N-acetylmuramidase) [Cell envelope biogenesis, outer membrane]; Region: Acm; COG3757 211110002363 PlyB is a bacteriophage endolysin that displays potent lytic activity toward Bacillus anthracis. PlyB has an N-terminal glycosyl hydrolase family 25 (GH25) catalytic domain and a C-terminal bacterial SH3-like domain, SH3b. Both domains are required for...; Region: GH25_PlyB-like; cd06523 211110002364 active site 211110002365 ECF-type riboflavin transporter, S component; Region: ECF-ribofla_trS; cl17272 211110002366 Protein of unknown function (DUF3816); Region: DUF3816; pfam12822 211110002367 oligoendopeptidase F; Region: pepF; TIGR00181 211110002368 Peptidase family M3B Oligopeptidase F (PepF); Region: M3B_PepF_4; cd09609 211110002369 active site 211110002370 Zn binding site [ion binding]; other site 211110002371 phosphoenolpyruvate carboxylase; Reviewed; Region: PRK00009 211110002372 Phosphoenolpyruvate carboxylase [Energy production and conversion]; Region: Ppc; COG2352 211110002373 Bacterial cell division membrane protein [Cell division and chromosome partitioning]; Region: FtsW; COG0772 211110002374 elongation factor Tu; Reviewed; Region: PRK00049 211110002375 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 211110002376 G1 box; other site 211110002377 GEF interaction site [polypeptide binding]; other site 211110002378 GTP/Mg2+ binding site [chemical binding]; other site 211110002379 Switch I region; other site 211110002380 G2 box; other site 211110002381 G3 box; other site 211110002382 Switch II region; other site 211110002383 G4 box; other site 211110002384 G5 box; other site 211110002385 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 211110002386 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 211110002387 Antibiotic Binding Site [chemical binding]; other site 211110002388 triosephosphate isomerase; Provisional; Region: PRK14567 211110002389 Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311 211110002390 substrate binding site [chemical binding]; other site 211110002391 dimer interface [polypeptide binding]; other site 211110002392 catalytic triad [active] 211110002393 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 211110002394 catalytic core [active] 211110002395 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 211110002396 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 211110002397 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 211110002398 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 211110002399 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 211110002400 recombination protein RecR; Reviewed; Region: recR; PRK00076 211110002401 RecR protein; Region: RecR; pfam02132 211110002402 TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR. RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025 211110002403 putative active site [active] 211110002404 putative metal-binding site [ion binding]; other site 211110002405 tetramer interface [polypeptide binding]; other site 211110002406 D-alanyl-alanine synthetase A; Reviewed; Region: ddl; PRK01966 211110002407 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 211110002408 D-ala D-ala ligase C-terminus; Region: Dala_Dala_lig_C; pfam07478 211110002409 UDP-N-acetylmuramyl pentapeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurF; COG0770 211110002410 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 211110002411 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 211110002412 oxalate/formate antiporter family transporter; Region: 2A0111; TIGR00890 211110002413 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 211110002414 putative substrate translocation pore; other site 211110002415 Integral membrane protein (intg_mem_TP0381); Region: Intg_mem_TP0381; pfam09529 211110002416 Gram positive anchor; Region: Gram_pos_anchor; pfam00746 211110002417 peptide chain release factor 3; Provisional; Region: prfC; PRK00741 211110002418 Release Factor 3 (RF3) protein involved in the terminal step of translocation in bacteria; Region: RF3; cd04169 211110002419 G1 box; other site 211110002420 putative GEF interaction site [polypeptide binding]; other site 211110002421 GTP/Mg2+ binding site [chemical binding]; other site 211110002422 Switch I region; other site 211110002423 G2 box; other site 211110002424 G3 box; other site 211110002425 Switch II region; other site 211110002426 G4 box; other site 211110002427 G5 box; other site 211110002428 RF3_II: this subfamily represents the domain II of bacterial Release Factor 3 (RF3). Termination of protein synthesis by the ribosome requires two release factor (RF) classes. The class II RF3 is a GTPase that removes class I RFs (RF1 or RF2) from the...; Region: RF3_II; cd03689 211110002429 Pleckstrin homology (PH)-like domains in bacteria (PHb); Region: PH-like_bacteria; cd13225 211110002430 pentamer interface [polypeptide binding]; other site 211110002431 dodecaamer interface [polypeptide binding]; other site 211110002432 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 211110002433 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 211110002434 Walker A/P-loop; other site 211110002435 ATP binding site [chemical binding]; other site 211110002436 Q-loop/lid; other site 211110002437 ABC transporter signature motif; other site 211110002438 Walker B; other site 211110002439 D-loop; other site 211110002440 H-loop/switch region; other site 211110002441 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 211110002442 dimer interface [polypeptide binding]; other site 211110002443 conserved gate region; other site 211110002444 putative PBP binding loops; other site 211110002445 ABC-ATPase subunit interface; other site 211110002446 ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464 211110002447 NLPA lipoprotein; Region: Lipoprotein_9; cl17547 211110002448 ATP-dependent RNA helicase SrmB; Provisional; Region: PRK11192 211110002449 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 211110002450 ATP binding site [chemical binding]; other site 211110002451 Mg++ binding site [ion binding]; other site 211110002452 motif III; other site 211110002453 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 211110002454 nucleotide binding region [chemical binding]; other site 211110002455 ATP-binding site [chemical binding]; other site 211110002456 The GIY-YIG domain of uncharacterized protein family UPF0213 related to structure-specific endonuclease SLX1; Region: GIY-YIG_UPF0213; cd10456 211110002457 GIY-YIG motif/motif A; other site 211110002458 putative active site [active] 211110002459 putative metal binding site [ion binding]; other site 211110002460 Predicted O-methyltransferase [General function prediction only]; Region: COG4123 211110002461 Methyltransferase domain; Region: Methyltransf_26; pfam13659 211110002462 S-adenosylmethionine binding site [chemical binding]; other site 211110002463 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 211110002464 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 211110002465 putative acyl-acceptor binding pocket; other site 211110002466 SLBB domain; Region: SLBB; pfam10531 211110002467 comEA protein; Region: comE; TIGR01259 211110002468 Fingers domain of DNA polymerase lambda; Region: DNA_pol_lambd_f; pfam10391 211110002469 Predicted membrane metal-binding protein [General function prediction only]; Region: ComEC; COG0658 211110002470 Domain of unknown function (DUF4131); Region: DUF4131; pfam13567 211110002471 Competence protein; Region: Competence; pfam03772 211110002472 Predicted hydrolase (metallo-beta-lactamase superfamily) [General function prediction only]; Region: ComEC; COG2333 211110002473 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 211110002474 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 211110002475 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 211110002476 active site 211110002477 motif I; other site 211110002478 motif II; other site 211110002479 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 211110002480 Transcriptional regulators [Transcription]; Region: PurR; COG1609 211110002481 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 211110002482 DNA binding site [nucleotide binding] 211110002483 domain linker motif; other site 211110002484 Ligand-binding domain of a novel transcription factor implicated in catabolite repression in Bacillus and Clostridium species; Region: PBP1_CcpB_like; cd06286 211110002485 putative ligand binding site [chemical binding]; other site 211110002486 putative dimerization interface [polypeptide binding]; other site 211110002487 Protein of unknown function (DUF2424); Region: DUF2424; pfam10340 211110002488 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 211110002489 Methyltransferase domain; Region: Methyltransf_23; pfam13489 211110002490 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 211110002491 S-adenosylmethionine binding site [chemical binding]; other site 211110002492 DNA polymerase III subunit delta; Reviewed; Region: holA; PRK05574 211110002493 DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144 211110002494 Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605 211110002495 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 211110002496 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 211110002497 transcriptional antiterminator BglG; Provisional; Region: PRK09772 211110002498 CAT RNA binding domain; Region: CAT_RBD; pfam03123 211110002499 PRD domain; Region: PRD; pfam00874 211110002500 PRD domain; Region: PRD; pfam00874 211110002501 PTS system, beta-glucoside-specific IIABC component; Region: PTS-II-ABC-beta; TIGR01995 211110002502 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 211110002503 active site turn [active] 211110002504 phosphorylation site [posttranslational modification] 211110002505 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 211110002506 PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_glc; cd00210 211110002507 HPr interaction site; other site 211110002508 glycerol kinase (GK) interaction site [polypeptide binding]; other site 211110002509 active site 211110002510 phosphorylation site [posttranslational modification] 211110002511 Beta-glucosidase/6-phospho-beta-glucosidase/beta- galactosidase [Carbohydrate transport and metabolism]; Region: BglB; COG2723 211110002512 beta-galactosidase; Region: BGL; TIGR03356 211110002513 Sugar diacid utilization regulator [Transcription / Signal transduction mechanisms]; Region: CdaR; COG3835 211110002514 Putative sugar diacid recognition; Region: Diacid_rec; pfam05651 211110002515 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 211110002516 glycerate kinase; Region: TIGR00045 211110002517 H+/gluconate symporter and related permeases [Carbohydrate transport and metabolism / Amino acid transport and metabolism]; Region: GntT; COG2610 211110002518 Beta-lactamase enzyme family; Region: Beta-lactamase2; pfam13354 211110002519 Transcriptional regulators [Transcription]; Region: MarR; COG1846 211110002520 MarR family; Region: MarR; pfam01047 211110002521 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Provisional; Region: queA; PRK00147 211110002522 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Region: queA; TIGR00113 211110002523 Nodulin-21 and CCC1-related protein family; Region: Nodulin-21_like_1; cd02432 211110002524 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363 211110002525 GlcN6P_deaminase: Glucosamine-6-phosphate (GlcN6P) deaminase subfamily; GlcN6P deaminase catalyzes the reversible conversion of GlcN6P to D-fructose-6-phosphate (Fru6P) and ammonium. The reaction is an aldo-keto isomerization coupled with an amination or...; Region: GlcN6P_deaminase; cd01399 211110002526 active site 211110002527 trimer interface [polypeptide binding]; other site 211110002528 allosteric site; other site 211110002529 active site lid [active] 211110002530 hexamer (dimer of trimers) interface [polypeptide binding]; other site 211110002531 Predicted glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: ECM4; COG0435 211110002532 Glutathione S-transferase, N-terminal domain; Region: GST_N_2; pfam13409 211110002533 C-terminal, alpha helical domain of Class Omega-like Glutathione S-transferases; Region: GST_C_Omega_like; cd03190 211110002534 putative dimer interface [polypeptide binding]; other site 211110002535 N-terminal domain interface [polypeptide binding]; other site 211110002536 putative substrate binding pocket (H-site) [chemical binding]; other site 211110002537 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 211110002538 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 211110002539 RNA binding surface [nucleotide binding]; other site 211110002540 Pseudouridine synthase, Escherichia coli RsuA like; Region: PseudoU_synth_RsuA; cd02553 211110002541 active site 211110002542 uracil binding [chemical binding]; other site 211110002543 Major Facilitator Superfamily; Region: MFS_1; pfam07690 211110002544 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 211110002545 putative substrate translocation pore; other site 211110002546 Competence protein CoiA-like family; Region: CoiA; pfam06054 211110002547 Oligoendopeptidase F [Amino acid transport and metabolism]; Region: COG1164 211110002548 Peptidase family M3B Oligopeptidase F (PepF); Region: M3B_PepF_3; cd09608 211110002549 active site 211110002550 Zn binding site [ion binding]; other site 211110002551 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 211110002552 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 211110002553 motif II; other site 211110002554 Predicted O-methyltransferase [General function prediction only]; Region: COG4122 211110002555 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 211110002556 S-adenosylmethionine binding site [chemical binding]; other site 211110002557 foldase protein PrsA; Reviewed; Region: prsA; PRK01326 211110002558 Tubby C 2; Region: Tub_2; cl02043 211110002559 alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252 211110002560 Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673 211110002561 motif 1; other site 211110002562 active site 211110002563 motif 2; other site 211110002564 motif 3; other site 211110002565 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 211110002566 DHHA1 domain; Region: DHHA1; pfam02272 211110002567 Protein of unknown function (DUF554); Region: DUF554; pfam04474 211110002568 A4GalT_like proteins catalyze the addition of galactose or glucose residues to the lipooligosaccharide (LOS) or lipopolysaccharide (LPS) of the bacterial cell surface; Region: GT8_A4GalT_like; cd04194 211110002569 Glycosyl transferase family 8; Region: Glyco_transf_8; pfam01501 211110002570 Ligand binding site; other site 211110002571 metal-binding site 211110002572 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 211110002573 non-specific DNA binding site [nucleotide binding]; other site 211110002574 salt bridge; other site 211110002575 sequence-specific DNA binding site [nucleotide binding]; other site 211110002576 Protein of unknown function (DUF3169); Region: DUF3169; pfam11368 211110002577 putative proton-coupled thiamine transporter YuaJ; Region: thia_yuaJ; TIGR02357 211110002578 ribonucleotide-diphosphate reductase subunit beta; Provisional; Region: nrdF2; PRK13966 211110002579 Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049 211110002580 dimer interface [polypeptide binding]; other site 211110002581 putative radical transfer pathway; other site 211110002582 diiron center [ion binding]; other site 211110002583 tyrosyl radical; other site 211110002584 ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK07306 211110002585 Ribonucleotide reductase N-terminal; Region: RNR_N; pfam08343 211110002586 Class I ribonucleotide reductase; Region: RNR_I; cd01679 211110002587 active site 211110002588 dimer interface [polypeptide binding]; other site 211110002589 catalytic residues [active] 211110002590 effector binding site; other site 211110002591 Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939 211110002592 NrdH-redoxin (NrdH) family; NrdH is a small monomeric protein with a conserved redox active CXXC motif within a TRX fold, characterized by a glutaredoxin (GRX)-like sequence and TRX-like activity profile. In vitro, it displays protein disulfide reductase...; Region: NrdH; cd02976 211110002593 catalytic residues [active] 211110002594 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 211110002595 dimerization domain swap beta strand [polypeptide binding]; other site 211110002596 regulatory protein interface [polypeptide binding]; other site 211110002597 active site 211110002598 regulatory phosphorylation site [posttranslational modification]; other site 211110002599 Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism]; Region: PtsA; COG1080 211110002600 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 211110002601 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 211110002602 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 211110002603 NADP+-dependent non-phosphorylating glyceraldehyde 3-phosphate dehydrogenase and ALDH family 11; Region: ALDH_F11_NP-GAPDH; cd07082 211110002604 NADP-dependent glyceraldehyde-3-phosphate dehydrogenase; Provisional; Region: PLN00412 211110002605 tetrameric interface [polypeptide binding]; other site 211110002606 activator binding site; other site 211110002607 NADP binding site [chemical binding]; other site 211110002608 substrate binding site [chemical binding]; other site 211110002609 catalytic residues [active] 211110002610 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 211110002611 Catalytic NodB homology domain of the carbohydrate esterase 4 superfamily; Region: CE4_SF; cl15692 211110002612 DEAD-like helicases superfamily; Region: DEXDc; smart00487 211110002613 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 211110002614 ATP binding site [chemical binding]; other site 211110002615 putative Mg++ binding site [ion binding]; other site 211110002616 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 211110002617 nucleotide binding region [chemical binding]; other site 211110002618 ATP-binding site [chemical binding]; other site 211110002619 Uridine kinase [Nucleotide transport and metabolism]; Region: Udk; COG0572 211110002620 Uridine monophosphate kinase (UMPK, EC 2.7.1.48), also known as uridine kinase or uridine-cytidine kinase (UCK), catalyzes the reversible phosphoryl transfer from ATP to uridine or cytidine to yield UMP or CMP. In the primidine nucleotide-salvage pathway; Region: UMPK; cd02023 211110002621 Sugar specificity; other site 211110002622 Pyrimidine base specificity; other site 211110002623 ATP-binding site [chemical binding]; other site 211110002624 GAF domain-containing protein [Signal transduction mechanisms]; Region: COG1956 211110002625 DNA polymerase III subunits gamma and tau; Validated; Region: PRK05563 211110002626 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 211110002627 Walker A motif; other site 211110002628 ATP binding site [chemical binding]; other site 211110002629 DNA polymerase III subunit delta'; Validated; Region: PRK08485 211110002630 Walker B motif; other site 211110002631 arginine finger; other site 211110002632 Protein of unknown function (DUF3272); Region: DUF3272; pfam11676 211110002633 Biotin operon repressor [Transcription]; Region: BirA; COG1654 211110002634 bifunctional biotin--[acetyl-CoA-carboxylase] synthetase/biotin operon repressor; Provisional; Region: PRK11886 211110002635 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; pfam03099 211110002636 Biotin protein ligase C terminal domain; Region: BPL_C; pfam02237 211110002637 S-adenosylmethionine synthetase; Validated; Region: PRK05250 211110002638 S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438 211110002639 S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772 211110002640 S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773 211110002641 Thiamine-precursor transporter protein (ThiW); Region: ThiW; pfam09512 211110002642 ABC-type cobalt transport system, permease component; Region: ABC_cobalt; pfam09819 211110002643 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 211110002644 cobalt transport protein ATP-binding subunit; Region: cbiO; TIGR01166 211110002645 Walker A/P-loop; other site 211110002646 ATP binding site [chemical binding]; other site 211110002647 Q-loop/lid; other site 211110002648 ABC transporter signature motif; other site 211110002649 Walker B; other site 211110002650 D-loop; other site 211110002651 H-loop/switch region; other site 211110002652 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 211110002653 cobalt transport protein ATP-binding subunit; Region: cbiO; TIGR01166 211110002654 Walker A/P-loop; other site 211110002655 ATP binding site [chemical binding]; other site 211110002656 Q-loop/lid; other site 211110002657 ABC transporter signature motif; other site 211110002658 Walker B; other site 211110002659 D-loop; other site 211110002660 H-loop/switch region; other site 211110002661 TENA/THI-4/PQQC family; Region: TENA_THI-4; cl15243 211110002662 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 211110002663 substrate binding site [chemical binding]; other site 211110002664 dimer interface [polypeptide binding]; other site 211110002665 ATP binding site [chemical binding]; other site 211110002666 4-methyl-5-beta-hydroxyethylthiazole (Thz) kinase catalyzes the phosphorylation of the hydroxylgroup of Thz. A reaction that allows cells to recycle Thz into the thiamine biosynthesis pathway, as an alternative to its synthesis from cysteine, tyrosine...; Region: THZ_kinase; cd01170 211110002667 substrate binding site [chemical binding]; other site 211110002668 multimerization interface [polypeptide binding]; other site 211110002669 ATP binding site [chemical binding]; other site 211110002670 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 211110002671 thiamine phosphate binding site [chemical binding]; other site 211110002672 active site 211110002673 pyrophosphate binding site [ion binding]; other site 211110002674 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 211110002675 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 211110002676 hinge; other site 211110002677 active site 211110002678 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 211110002679 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 211110002680 Predicted transcriptional regulator containing CBS domains [Transcription]; Region: COG4109 211110002681 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 211110002682 DNA-binding site [nucleotide binding]; DNA binding site 211110002683 DRTGG domain; Region: DRTGG; pfam07085 211110002684 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with a DRTGG domain upstream. The function of the DRTGG domain, named after its conserved residues, is unknown. CBS is a small domain originally...; Region: CBS_pair_DRTGG_assoc; cd04596 211110002685 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cd03440 211110002686 active site 2 [active] 211110002687 active site 1 [active] 211110002688 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 211110002689 active site 211110002690 Ribonuclease BN family enzyme [Replication, recombination, and repair]; Region: Rbn; COG1295 211110002691 GtrA-like protein; Region: GtrA; pfam04138 211110002692 Predicted membrane protein [Function unknown]; Region: COG2246 211110002693 Predicted membrane protein [Function unknown]; Region: COG4708 211110002694 NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956 211110002695 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114 211110002696 nucleotide binding pocket [chemical binding]; other site 211110002697 K-X-D-G motif; other site 211110002698 catalytic site [active] 211110002699 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 211110002700 NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119 211110002701 Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027 211110002702 Dimer interface [polypeptide binding]; other site 211110002703 BRCT sequence motif; other site 211110002704 putative lipid kinase; Reviewed; Region: PRK13055 211110002705 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 211110002706 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; cl17465 211110002707 Family 41 Carbohydrate-Binding Module from pullulanase-like enzymes; Region: CBM41_pullulanase; cd10315 211110002708 carbohydrate binding site [chemical binding]; other site 211110002709 pullulanase, type I; Region: pulA_typeI; TIGR02104 211110002710 Early set domain associated with the catalytic domain of pullulanase (also called dextrinase and alpha-dextrin endo-1,6-alpha glucosidase); Region: E_set_Pullulanase; cd02860 211110002711 Alpha amylase catalytic domain found in Pullulanase (also called dextrinase; alpha-dextrin endo-1,6-alpha glucosidase), limit dextrinase, and related proteins; Region: AmyAc_Pullulanase_LD-like; cd11341 211110002712 Ca binding site [ion binding]; other site 211110002713 active site 211110002714 catalytic site [active] 211110002715 glycogen branching enzyme; Provisional; Region: PRK12313 211110002716 N-terminal Early set domain associated with the catalytic domain of prokaryotic glycogen branching enzyme; Region: E_set_GBE_prok_N; cd02855 211110002717 Alpha amylase catalytic domain found in the Glycogen branching enzyme (also called 1,4-alpha-glucan branching enzyme); Region: AmyAc_Glg_BE; cd11322 211110002718 active site 211110002719 catalytic site [active] 211110002720 Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; pfam02806 211110002721 glucose-1-phosphate adenylyltransferase; Provisional; Region: glgC; PRK05293 211110002722 ADP-glucose pyrophosphorylase is involved in the biosynthesis of glycogen or starch; Region: ADP_Glucose_PP; cd02508 211110002723 ligand binding site; other site 211110002724 oligomer interface; other site 211110002725 Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651 211110002726 dimer interface [polypeptide binding]; other site 211110002727 N-terminal domain interface [polypeptide binding]; other site 211110002728 sulfate 1 binding site; other site 211110002729 glucose-1-phosphate adenylyltransferase, GlgD subunit; Region: glgD; TIGR02092 211110002730 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 211110002731 active site 211110002732 Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651 211110002733 dimer interface [polypeptide binding]; other site 211110002734 N-terminal domain interface [polypeptide binding]; other site 211110002735 sulfate 1 binding site; other site 211110002736 glycogen synthase; Provisional; Region: glgA; PRK00654 211110002737 This family is most closely related to the GT1 family of glycosyltransferases. Glycogen synthase catalyzes the formation and elongation of the alpha-1,4-glucose backbone using ADP-glucose, the second and key step of glycogen biosynthesis. This family...; Region: GT1_Glycogen_synthase_DULL1_like; cd03791 211110002738 ADP-binding pocket [chemical binding]; other site 211110002739 homodimer interface [polypeptide binding]; other site 211110002740 F0F1 ATP synthase subunit C; Provisional; Region: PRK13467 211110002741 F0F1 ATP synthase subunit A; Validated; Region: PRK05815 211110002742 F0F1-type ATP synthase, subunit a [Energy production and conversion]; Region: AtpB; COG0356 211110002743 F0F1 ATP synthase subunit B; Validated; Region: PRK05759 211110002744 F0F1-type ATP synthase, subunit b [Energy production and conversion]; Region: AtpF; COG0711 211110002745 F0F1 ATP synthase subunit delta; Validated; Region: PRK05758 211110002746 ATP synthase delta (OSCP) subunit; Region: OSCP; pfam00213 211110002747 F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281 211110002748 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 211110002749 F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132 211110002750 beta subunit interaction interface [polypeptide binding]; other site 211110002751 Walker A motif; other site 211110002752 ATP binding site [chemical binding]; other site 211110002753 Walker B motif; other site 211110002754 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 211110002755 mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151 211110002756 core domain interface [polypeptide binding]; other site 211110002757 delta subunit interface [polypeptide binding]; other site 211110002758 epsilon subunit interface [polypeptide binding]; other site 211110002759 F0F1 ATP synthase subunit beta; Validated; Region: PRK09280 211110002760 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 211110002761 F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133 211110002762 alpha subunit interaction interface [polypeptide binding]; other site 211110002763 Walker A motif; other site 211110002764 ATP binding site [chemical binding]; other site 211110002765 Walker B motif; other site 211110002766 inhibitor binding site; inhibition site 211110002767 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 211110002768 F0F1 ATP synthase subunit epsilon; Validated; Region: atpC; PRK00571 211110002769 mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152 211110002770 gamma subunit interface [polypeptide binding]; other site 211110002771 epsilon subunit interface [polypeptide binding]; other site 211110002772 LBP interface [polypeptide binding]; other site 211110002773 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 211110002774 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 211110002775 hinge; other site 211110002776 active site 211110002777 DNA-directed RNA polymerase subunit beta; Region: EpuA; pfam11772 211110002778 DNA/RNA non-specific endonuclease; Region: Endonuclease_NS; pfam01223 211110002779 DNA/RNA non-specific endonuclease; Region: Endonuclease_NS; smart00892 211110002780 phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488 211110002781 Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912 211110002782 Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496 211110002783 dimer interface [polypeptide binding]; other site 211110002784 motif 1; other site 211110002785 active site 211110002786 motif 2; other site 211110002787 motif 3; other site 211110002788 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 211110002789 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 211110002790 Coenzyme A binding pocket [chemical binding]; other site 211110002791 phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629 211110002792 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 211110002793 putative tRNA-binding site [nucleotide binding]; other site 211110002794 B3/4 domain; Region: B3_4; pfam03483 211110002795 tRNA synthetase B5 domain; Region: B5; smart00874 211110002796 Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA, PheRS is an...; Region: PheRS_beta_core; cd00769 211110002797 dimer interface [polypeptide binding]; other site 211110002798 motif 1; other site 211110002799 motif 3; other site 211110002800 motif 2; other site 211110002801 Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; pfam03147 211110002802 similar to unknown proteins (C-terminal part);Unknown 211110002803 ATP-dependent nuclease subunit B; Region: rexB_recomb; TIGR02774 211110002804 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 211110002805 helicase-exonuclease AddAB, AddA subunit, Firmicutes type; Region: addA_Gpos; TIGR02785 211110002806 Part of AAA domain; Region: AAA_19; pfam13245 211110002807 Family description; Region: UvrD_C_2; pfam13538 211110002808 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 211110002809 CorA-like Mg2+ transporter protein; Region: CorA; pfam01544 211110002810 uncharacterized bacterial subfamily of the Escherichia coli CorA-Salmonella typhimurium ZntB family; Region: EcCorA_ZntB-like_u2; cd12827 211110002811 Cl binding site [ion binding]; other site 211110002812 oligomer interface [polypeptide binding]; other site 211110002813 tRNA modification GTPase TrmE; Reviewed; Region: trmE; PRK05291 211110002814 GTP-binding protein TrmE N-terminus; Region: TrmE_N; pfam10396 211110002815 trmE is a tRNA modification GTPase; Region: trmE; cd04164 211110002816 G1 box; other site 211110002817 GTP/Mg2+ binding site [chemical binding]; other site 211110002818 Switch I region; other site 211110002819 G2 box; other site 211110002820 Switch II region; other site 211110002821 G3 box; other site 211110002822 G4 box; other site 211110002823 G5 box; other site 211110002824 Catalytic cysteine-containing C-terminus of GTPase, MnmE; Region: GTPase_Cys_C; pfam12631 211110002825 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 211110002826 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 211110002827 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 211110002828 ABC transporter; Region: ABC_tran_2; pfam12848 211110002829 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 211110002830 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, alpha subunit [Energy production and conversion]; Region: AcoA; COG1071 211110002831 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 211110002832 tetramer interface [polypeptide binding]; other site 211110002833 TPP-binding site [chemical binding]; other site 211110002834 heterodimer interface [polypeptide binding]; other site 211110002835 phosphorylation loop region [posttranslational modification] 211110002836 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 211110002837 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 211110002838 alpha subunit interface [polypeptide binding]; other site 211110002839 TPP binding site [chemical binding]; other site 211110002840 heterodimer interface [polypeptide binding]; other site 211110002841 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 211110002842 branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856 211110002843 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 211110002844 E3 interaction surface; other site 211110002845 lipoyl attachment site [posttranslational modification]; other site 211110002846 e3 binding domain; Region: E3_binding; pfam02817 211110002847 e3 binding domain; Region: E3_binding; pfam02817 211110002848 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 211110002849 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 211110002850 E3 interaction surface; other site 211110002851 lipoyl attachment site [posttranslational modification]; other site 211110002852 dihydrolipoamide dehydrogenase; Region: lipoamide_DH; TIGR01350 211110002853 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 211110002854 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 211110002855 Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095 211110002856 lipoyltransferase and lipoate-protein ligase; Region: lipoyltrans; TIGR00545 211110002857 Bacterial lipoate protein ligase C-terminus; Region: Lip_prot_lig_C; pfam10437 211110002858 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyric Acid Synthase (CobQ); Region: GATase1_CobQ; cd01750 211110002859 catalytic triad [active] 211110002860 UDP-N-acetylmuramyl tripeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurE; COG0769 211110002861 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 211110002862 Domain of unknown function (DUF1727); Region: DUF1727; pfam08353 211110002863 Uncharacterized conserved protein [Function unknown]; Region: COG1624 211110002864 DisA bacterial checkpoint controller nucleotide-binding; Region: DisA_N; pfam02457 211110002865 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4856 211110002866 YbbR-like protein; Region: YbbR; pfam07949 211110002867 phosphoglucosamine mutase; Provisional; Region: glmM; PRK14316 211110002868 GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802 211110002869 active site 211110002870 substrate binding site [chemical binding]; other site 211110002871 metal binding site [ion binding]; metal-binding site 211110002872 Protein of unknown function (DUF1722); Region: DUF1722; cl01284 211110002873 conserved hypothetical protein; Region: TIGR02328 211110002874 Pyrimidine dimer DNA glycosylase; Region: Pyr_excise; pfam03013 211110002875 coproporphyrinogen III oxidase; Provisional; Region: PRK08599 211110002876 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 211110002877 FeS/SAM binding site; other site 211110002878 HemN C-terminal domain; Region: HemN_C; pfam06969 211110002879 Acyl-ACP thioesterase; Region: Acyl-ACP_TE; pfam01643 211110002880 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 211110002881 active site 211110002882 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 211110002883 active site 2 [active] 211110002884 active site 1 [active] 211110002885 HAD-superfamily subfamily IIA hydrolase, TIGR01457; Region: HAD-SF-IIA-hyp2 211110002886 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 211110002887 active site 211110002888 motif I; other site 211110002889 motif II; other site 211110002890 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 211110002891 Protein of unknown function (DUF1461); Region: DUF1461; pfam07314 211110002892 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cl00083 211110002893 CRISPR/Cas system-associated protein Cas9; Region: Csn1; cd09643 211110002894 CRISPR/Cas system-associated protein Cas1; Region: Cas1_II; cd09720 211110002895 CRISPR/Cas system-associated protein Cas2; Region: Cas2_I_II_III; cd09638 211110002896 CRISPR/Cas system-associated protein Csn2; Region: Csn2; cd09758 211110002897 CRISPR type II-A/NMEMI-associated protein Csn2; Region: cas_Csn2; TIGR01866 211110002898 tetramer interface [polypeptide binding]; other site 211110002899 putative DNA binding site [nucleotide binding]; other site 211110002900 Ca binding site [ion binding]; other site 211110002901 Ca binding site [ion binding]; other site 211110002902 Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413 211110002903 active site 211110002904 multimer interface [polypeptide binding]; other site 211110002905 GTP-binding protein LepA; Provisional; Region: PRK05433 211110002906 LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890 211110002907 G1 box; other site 211110002908 putative GEF interaction site [polypeptide binding]; other site 211110002909 GTP/Mg2+ binding site [chemical binding]; other site 211110002910 Switch I region; other site 211110002911 G2 box; other site 211110002912 G3 box; other site 211110002913 Switch II region; other site 211110002914 G4 box; other site 211110002915 G5 box; other site 211110002916 lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699 211110002917 lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane. LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709 211110002918 GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421 211110002919 streptococcal histidine triad protein; Region: strep_his_triad; TIGR01363 211110002920 Streptococcal histidine triad protein; Region: Strep_his_triad; pfam04270 211110002921 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 211110002922 Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond...; Region: LRR_RI; cl15309 211110002923 Substrate binding site [chemical binding]; other site 211110002924 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 211110002925 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 211110002926 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 211110002927 Predicted HD superfamily hydrolase [General function prediction only]; Region: COG1418 211110002928 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 211110002929 Zn2+ binding site [ion binding]; other site 211110002930 Mg2+ binding site [ion binding]; other site 211110002931 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 211110002932 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 211110002933 Coenzyme A binding pocket [chemical binding]; other site 211110002934 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 211110002935 methionine sulfoxide reductase B; Provisional; Region: PRK00222 211110002936 SelR domain; Region: SelR; pfam01641 211110002937 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; pfam00690 211110002938 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 211110002939 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 211110002940 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 211110002941 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 211110002942 motif II; other site 211110002943 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 211110002944 Protein of unknown function (DUF2974); Region: DUF2974; pfam11187 211110002945 Xenobiotic acyltransferase (XAT): The XAT class of hexapeptide acyltransferases is composed of a large number of microbial enzymes that catalyze the CoA-dependent acetylation of a variety of hydroxyl-bearing acceptors such as chloramphenicol and...; Region: LbH_XAT; cd03349 211110002946 trimer interface [polypeptide binding]; other site 211110002947 active site 211110002948 substrate binding site [chemical binding]; other site 211110002949 CoA binding site [chemical binding]; other site 211110002950 Uncharacterized conserved protein [Function unknown]; Region: COG0398 211110002951 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 211110002952 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 211110002953 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 211110002954 Walker A/P-loop; other site 211110002955 ATP binding site [chemical binding]; other site 211110002956 Q-loop/lid; other site 211110002957 ABC transporter signature motif; other site 211110002958 Walker B; other site 211110002959 D-loop; other site 211110002960 H-loop/switch region; other site 211110002961 Predicted transcriptional regulators [Transcription]; Region: COG1725 211110002962 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 211110002963 DNA-binding site [nucleotide binding]; DNA binding site 211110002964 DNA polymerase III DnaE; Reviewed; Region: dnaE; PRK07279 211110002965 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III; Region: PHP_PolIIIA; cd07431 211110002966 active site 211110002967 PHP Thumb interface [polypeptide binding]; other site 211110002968 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 211110002969 generic binding surface II; other site 211110002970 generic binding surface I; other site 211110002971 Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to a subfamily of the PFKA family (cd00363) and include bacterial ATP-dependent...; Region: Bacterial_PFK; cd00763 211110002972 6-phosphofructokinase; Region: PFKA_ATP; TIGR02482 211110002973 active site 211110002974 ADP/pyrophosphate binding site [chemical binding]; other site 211110002975 dimerization interface [polypeptide binding]; other site 211110002976 allosteric effector site; other site 211110002977 fructose-1,6-bisphosphate binding site; other site 211110002978 pyruvate kinase; Provisional; Region: PRK05826 211110002979 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342 211110002980 domain interfaces; other site 211110002981 active site 211110002982 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 211110002983 Peptidase S24-like; Region: Peptidase_S24; pfam00717 211110002984 Catalytic site [active] 211110002985 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 211110002986 glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331 211110002987 Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans). The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714 211110002988 glutaminase active site [active] 211110002989 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 211110002990 dimer interface [polypeptide binding]; other site 211110002991 active site 211110002992 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 211110002993 dimer interface [polypeptide binding]; other site 211110002994 active site 211110002995 Uncharacterized Zn-ribbon-containing protein involved in phosphonate metabolism [Inorganic ion transport and metabolism]; Region: PhnA; COG2824 211110002996 PhnA Zinc-Ribbon; Region: PhnA_Zn_Ribbon; pfam08274 211110002997 PhnA protein; Region: PhnA; pfam03831 211110002998 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 211110002999 dimer interface [polypeptide binding]; other site 211110003000 conserved gate region; other site 211110003001 putative PBP binding loops; other site 211110003002 ABC-ATPase subunit interface; other site 211110003003 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 211110003004 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 211110003005 Walker A/P-loop; other site 211110003006 ATP binding site [chemical binding]; other site 211110003007 Q-loop/lid; other site 211110003008 ABC transporter signature motif; other site 211110003009 Walker B; other site 211110003010 D-loop; other site 211110003011 H-loop/switch region; other site 211110003012 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 211110003013 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 211110003014 substrate binding pocket [chemical binding]; other site 211110003015 membrane-bound complex binding site; other site 211110003016 hinge residues; other site 211110003017 30S ribosomal protein S20; Reviewed; Region: rpsT; PRK00239 211110003018 pantothenate kinase; Provisional; Region: PRK05439 211110003019 Pantothenate kinase (PanK) catalyzes the phosphorylation of pantothenic acid to form 4'-phosphopantothenic, which is the first of five steps in coenzyme A (CoA) biosynthetic pathway. The reaction carried out by this enzyme is a key regulatory point...; Region: PanK; cd02025 211110003020 ATP-binding site [chemical binding]; other site 211110003021 CoA-binding site [chemical binding]; other site 211110003022 Mg2+-binding site [ion binding]; other site 211110003023 Methyltransferase domain; Region: Methyltransf_31; pfam13847 211110003024 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 211110003025 S-adenosylmethionine binding site [chemical binding]; other site 211110003026 Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283 211110003027 active site 211110003028 catalytic motif [active] 211110003029 Zn binding site [ion binding]; other site 211110003030 Uncharacterized ABC-type transport system, periplasmic component/surface lipoprotein [General function prediction only]; Region: Med; COG1744 211110003031 Periplasmic binding domain of basic membrane lipoprotein, PnrA, in Treponema pallidum and its homologs from other bacteria and Archaea; Region: PBP1_BmpA_PnrA_like; cd06354 211110003032 ligand binding site [chemical binding]; other site 211110003033 ABC-type uncharacterized transport systems, ATPase components [General function prediction only]; Region: COG3845 211110003034 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 211110003035 Walker A/P-loop; other site 211110003036 ATP binding site [chemical binding]; other site 211110003037 Q-loop/lid; other site 211110003038 ABC transporter signature motif; other site 211110003039 Walker B; other site 211110003040 D-loop; other site 211110003041 H-loop/switch region; other site 211110003042 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 211110003043 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 211110003044 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 211110003045 TM-ABC transporter signature motif; other site 211110003046 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 211110003047 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 211110003048 TM-ABC transporter signature motif; other site 211110003049 coenzyme A disulfide reductase; Reviewed; Region: PRK09564 211110003050 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 211110003051 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 211110003052 L-lactate dehydrogenase; Reviewed; Region: ldh; PRK00066 211110003053 L-2-hydroxyisocapronate dehydrogenases and some bacterial L-lactate dehydrogenases; Region: HicDH_like; cd05291 211110003054 tetramer (dimer of dimers) interface [polypeptide binding]; other site 211110003055 NAD binding site [chemical binding]; other site 211110003056 dimer interface [polypeptide binding]; other site 211110003057 substrate binding site [chemical binding]; other site 211110003058 DNA gyrase subunit A; Validated; Region: PRK05560 211110003059 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 211110003060 CAP-like domain; other site 211110003061 active site 211110003062 primary dimer interface [polypeptide binding]; other site 211110003063 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 211110003064 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 211110003065 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 211110003066 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 211110003067 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 211110003068 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 211110003069 Sortase A (SrtA) or subfamily-1 sortases are cysteine transpeptidases found in gram-positive bacteria that anchor surface proteins to peptidoglycans of the bacterial cell wall envelope. They do so by catalyzing a transpeptidation reaction in which the...; Region: Sortase_A_1; cd06165 211110003070 active site 211110003071 catalytic site [active] 211110003072 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_1; cd08352 211110003073 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 211110003074 putative metal binding site [ion binding]; other site 211110003075 Predicted secreted protein [Function unknown]; Region: COG4086 211110003076 Protein of unknown function (DUF1002); Region: DUF1002; pfam06207 211110003077 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475 211110003078 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 211110003079 GMP synthase; Reviewed; Region: guaA; PRK00074 211110003080 Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742 211110003081 AMP/PPi binding site [chemical binding]; other site 211110003082 candidate oxyanion hole; other site 211110003083 catalytic triad [active] 211110003084 potential glutamine specificity residues [chemical binding]; other site 211110003085 The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997 211110003086 ATP Binding subdomain [chemical binding]; other site 211110003087 Dimerization subdomain; other site 211110003088 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 211110003089 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 211110003090 DNA-binding site [nucleotide binding]; DNA binding site 211110003091 UTRA domain; Region: UTRA; pfam07702 211110003092 tRNA (uracil-5-)-methyltransferase Gid; Reviewed; Region: PRK05335 211110003093 Glucose inhibited division protein A; Region: GIDA; pfam01134 211110003094 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 211110003095 Coenzyme A binding pocket [chemical binding]; other site 211110003096 ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464 211110003097 NLPA lipoprotein; Region: Lipoprotein_9; pfam03180 211110003098 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 211110003099 C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526 211110003100 similar to Lactococcus lactis nisin-resistance protein C-terminal part;unknown 211110003101 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 211110003102 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 211110003103 Walker A/P-loop; other site 211110003104 ATP binding site [chemical binding]; other site 211110003105 Q-loop/lid; other site 211110003106 ABC transporter signature motif; other site 211110003107 Walker B; other site 211110003108 D-loop; other site 211110003109 H-loop/switch region; other site 211110003110 FtsX-like permease family; Region: FtsX; pfam02687 211110003111 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 211110003112 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 211110003113 active site 211110003114 phosphorylation site [posttranslational modification] 211110003115 intermolecular recognition site; other site 211110003116 dimerization interface [polypeptide binding]; other site 211110003117 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 211110003118 DNA binding site [nucleotide binding] 211110003119 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 211110003120 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 211110003121 ATP binding site [chemical binding]; other site 211110003122 Mg2+ binding site [ion binding]; other site 211110003123 G-X-G motif; other site 211110003124 site-specific tyrosine recombinase XerS; Reviewed; Region: xerS; PRK05084 211110003125 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 211110003126 active site 211110003127 DNA binding site [nucleotide binding] 211110003128 Int/Topo IB signature motif; other site 211110003129 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 211110003130 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 211110003131 peptide binding site [polypeptide binding]; other site 211110003132 Protein of unknown function (DUF3307); Region: DUF3307; pfam11750 211110003133 Uncharacterized protein family (UPF0236); Region: UPF0236; pfam06782 211110003134 Replication initiator protein A (RepA) N-terminus; Region: RepA_N; pfam06970 211110003135 MarR family; Region: MarR_2; cl17246 211110003136 Antiactivator of flagellar biosynthesis FleN, an ATPase [Cell motility]; Region: flhG; COG0455 211110003137 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 211110003138 Mannosyl-glycoprotein endo-beta-N-acetylglucosaminidase; Region: Glucosaminidase; pfam01832 211110003139 CHAP domain; Region: CHAP; cl17642 211110003140 Ribosomal protein L6e; Region: Ribosomal_L6e; pfam01159 211110003141 AAA-like domain; Region: AAA_10; pfam12846 211110003142 Lantibiotic dehydratase, C terminus; Region: Lant_dehyd_C; pfam04738 211110003143 DNA polymerase III subunit epsilon; Validated; Region: PRK06195 211110003144 conjugal transfer protein TrbL; Provisional; Region: PRK13875 211110003145 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 211110003146 Walker A motif; other site 211110003147 ATP binding site [chemical binding]; other site 211110003148 Type IV secretory pathway, VirD4 components [Intracellular trafficking and secretion]; Region: VirD4; COG3505 211110003149 TraM recognition site of TraD and TraG; Region: TraG-D_C; pfam12696 211110003150 kinesin-12 family protein; Provisional; Region: PLN03188 211110003151 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 211110003152 dimer interface [polypeptide binding]; other site 211110003153 ssDNA binding site [nucleotide binding]; other site 211110003154 tetramer (dimer of dimers) interface [polypeptide binding]; other site 211110003155 putative cross-wall-targeting lipoprotein signal; Region: strep_RK_lipo; TIGR03726 211110003156 Membrane protein involved in colicin uptake [Cell envelope biogenesis, outer membrane]; Region: TolA; COG3064 211110003157 adhesin isopeptide-forming domain, sspB-C2 type; Region: isopep_sspB_C2; TIGR04228 211110003158 LPXTG-motif cell wall anchor domain; Region: LPXTG_anchor; TIGR01167 211110003159 LPXTG-motif cell wall anchor domain; Region: LPXTG_anchor; TIGR01167 211110003160 A sub-family of peptidase family C39. Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various...; Region: Peptidase_C39A; cd02549 211110003161 putative active site [active] 211110003162 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 211110003163 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 211110003164 Walker A motif; other site 211110003165 ATP binding site [chemical binding]; other site 211110003166 Walker B motif; other site 211110003167 arginine finger; other site 211110003168 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 211110003169 Walker A motif; other site 211110003170 ATP binding site [chemical binding]; other site 211110003171 Walker B motif; other site 211110003172 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 211110003173 DNA topoisomerase III; Provisional; Region: PRK07726 211110003174 TOPRIM_TopoIA_TopoIII: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to topoisomerase III. Type IA DNA topoisomerases remove (relax) negative supercoils in the DNA by: cleaving...; Region: TOPRIM_TopoIA_TopoIII; cd03362 211110003175 active site 211110003176 putative interdomain interaction site [polypeptide binding]; other site 211110003177 putative metal-binding site [ion binding]; other site 211110003178 putative nucleotide binding site [chemical binding]; other site 211110003179 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 211110003180 domain I; other site 211110003181 DNA binding groove [nucleotide binding] 211110003182 phosphate binding site [ion binding]; other site 211110003183 domain II; other site 211110003184 domain III; other site 211110003185 nucleotide binding site [chemical binding]; other site 211110003186 catalytic site [active] 211110003187 domain IV; other site 211110003188 Protein of unknown function (DUF3991); Region: DUF3991; pfam13154 211110003189 Domain of unknown function (DUF955); Region: DUF955; pfam06114 211110003190 DNA/RNA non-specific endonuclease; Region: Endonuclea_NS_2; cl17626 211110003191 DNA/RNA non-specific endonuclease; Region: Endonuclease_NS; smart00892 211110003192 Transcriptional regulatory protein LGE1; Region: Lge1; pfam11488 211110003193 Chromosome segregation ATPases [Cell division and chromosome partitioning]; Region: Smc; COG1196 211110003194 Glutaredoxin-like domain (DUF836); Region: DUF836; cl17650 211110003195 Primase C terminal 1 (PriCT-1); Region: PriCT_1; pfam08708 211110003196 signal recognition particle protein; Provisional; Region: PRK10867 211110003197 SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963 211110003198 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 211110003199 P loop; other site 211110003200 GTP binding site [chemical binding]; other site 211110003201 Signal peptide binding domain; Region: SRP_SPB; pfam02978 211110003202 putative DNA-binding protein; Validated; Region: PRK00118 211110003203 Putative helix-turn-helix protein, YlxM / p13 like; Region: UPF0122; pfam04297 211110003204 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 211110003205 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 211110003206 dimer interface [polypeptide binding]; other site 211110003207 phosphorylation site [posttranslational modification] 211110003208 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 211110003209 ATP binding site [chemical binding]; other site 211110003210 Mg2+ binding site [ion binding]; other site 211110003211 G-X-G motif; other site 211110003212 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 211110003213 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 211110003214 active site 211110003215 phosphorylation site [posttranslational modification] 211110003216 intermolecular recognition site; other site 211110003217 dimerization interface [polypeptide binding]; other site 211110003218 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 211110003219 DNA binding site [nucleotide binding] 211110003220 Peptidase M1 Aminopeptidase N family incudes tricorn interacting factor F3, Endoplasmic reticulum aminopeptidase 1 (ERAP1), Aminopeptidase Q (APQ); Region: M1_APN_2; cd09601 211110003221 Aminopeptidase N [Amino acid transport and metabolism]; Region: PepN; COG0308 211110003222 Zn binding site [ion binding]; other site 211110003223 phosphate transport system regulatory protein PhoU; Region: phoU_full; TIGR02135 211110003224 PhoU domain; Region: PhoU; pfam01895 211110003225 PhoU domain; Region: PhoU; pfam01895 211110003226 phosphate transporter ATP-binding protein; Provisional; Region: PRK14239 211110003227 ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260 211110003228 Walker A/P-loop; other site 211110003229 ATP binding site [chemical binding]; other site 211110003230 Q-loop/lid; other site 211110003231 ABC transporter signature motif; other site 211110003232 Walker B; other site 211110003233 D-loop; other site 211110003234 H-loop/switch region; other site 211110003235 phosphate transporter ATP-binding protein; Provisional; Region: PRK14237 211110003236 ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260 211110003237 Walker A/P-loop; other site 211110003238 ATP binding site [chemical binding]; other site 211110003239 Q-loop/lid; other site 211110003240 ABC transporter signature motif; other site 211110003241 Walker B; other site 211110003242 D-loop; other site 211110003243 H-loop/switch region; other site 211110003244 ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstA; COG0581 211110003245 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 211110003246 dimer interface [polypeptide binding]; other site 211110003247 conserved gate region; other site 211110003248 putative PBP binding loops; other site 211110003249 ABC-ATPase subunit interface; other site 211110003250 ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstC; COG0573 211110003251 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 211110003252 dimer interface [polypeptide binding]; other site 211110003253 conserved gate region; other site 211110003254 putative PBP binding loops; other site 211110003255 ABC-ATPase subunit interface; other site 211110003256 PBP superfamily domain; Region: PBP_like_2; cl17296 211110003257 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 211110003258 rRNA (cytosine-C(5)-)-methyltransferase RsmF; Reviewed; Region: yebU; PRK11933 211110003259 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 211110003260 S-adenosylmethionine binding site [chemical binding]; other site 211110003261 pre-rRNA processing and ribosome biogenesis; Region: Nol1_Nop2_Fmu_2; pfam13636 211110003262 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 211110003263 Inositol-monophosphatase-like domains. This family of phosphatases is dependent on bivalent metal ions such as Mg++, and many members are inhibited by Li+ (which is thought to displace a bivalent ion in the active site). Substrates include fructose-1; Region: IMPase_like; cd01637 211110003264 active site 211110003265 hypothetical protein; Provisional; Region: PRK04387 211110003266 Arsenate Reductase (ArsC) family, Spx subfamily; Spx is a unique RNA polymerase (RNAP)-binding protein present in bacilli and some mollicutes. It inhibits transcription by binding to the C-terminal domain of the alpha subunit of RNAP, disrupting complex...; Region: ArsC_Spx; cd03032 211110003267 ArsC family; Region: ArsC; pfam03960 211110003268 putative catalytic residues [active] 211110003269 thiol/disulfide switch; other site 211110003270 bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627 211110003271 FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064 211110003272 active site 211110003273 Riboflavin kinase; Region: Flavokinase; smart00904 211110003274 tRNA pseudouridine synthase B; Provisional; Region: truB; PRK02484 211110003275 Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573 211110003276 RNA binding site [nucleotide binding]; other site 211110003277 active site 211110003278 tRNA Pseudouridine synthase II, C terminal; Region: TruB_C; pfam09142 211110003279 Acetyltransferase (GNAT) domain; Region: Acetyltransf_4; pfam13420 211110003280 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 211110003281 Coenzyme A binding pocket [chemical binding]; other site 211110003282 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4487 211110003283 Uncharacterized protein conserved in bacteria (DUF2130); Region: DUF2130; pfam09903 211110003284 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 211110003285 CAAX protease self-immunity; Region: Abi; pfam02517 211110003286 FtsX-like permease family; Region: FtsX; pfam02687 211110003287 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 211110003288 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 211110003289 FtsX-like permease family; Region: FtsX; pfam02687 211110003290 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 211110003291 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 211110003292 Walker A/P-loop; other site 211110003293 ATP binding site [chemical binding]; other site 211110003294 Q-loop/lid; other site 211110003295 ABC transporter signature motif; other site 211110003296 Walker B; other site 211110003297 D-loop; other site 211110003298 H-loop/switch region; other site 211110003299 DNA topoisomerase I; Validated; Region: PRK05582 211110003300 TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I. Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363 211110003301 active site 211110003302 interdomain interaction site; other site 211110003303 putative metal-binding site [ion binding]; other site 211110003304 nucleotide binding site [chemical binding]; other site 211110003305 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 211110003306 domain I; other site 211110003307 DNA binding groove [nucleotide binding] 211110003308 phosphate binding site [ion binding]; other site 211110003309 domain II; other site 211110003310 domain III; other site 211110003311 nucleotide binding site [chemical binding]; other site 211110003312 catalytic site [active] 211110003313 domain IV; other site 211110003314 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 211110003315 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 211110003316 DNA recombination-mediator protein A; Region: DNA_processg_A; pfam02481 211110003317 DNA protecting protein DprA; Region: dprA; TIGR00732 211110003318 Siderophore binding protein FatB. These proteins have been shown to function as ABC-type initial receptors in the siderophore-mediated iron uptake in some eubacterial species. They belong to the TroA superfamily of periplasmic metal binding proteins...; Region: FatB; cd01140 211110003319 putative ligand binding residues [chemical binding]; other site 211110003320 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 211110003321 ABC-type enterochelin transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CeuD; COG4604 211110003322 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 211110003323 Walker A/P-loop; other site 211110003324 ATP binding site [chemical binding]; other site 211110003325 Q-loop/lid; other site 211110003326 ABC transporter signature motif; other site 211110003327 Walker B; other site 211110003328 D-loop; other site 211110003329 H-loop/switch region; other site 211110003330 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 211110003331 ABC-ATPase subunit interface; other site 211110003332 dimer interface [polypeptide binding]; other site 211110003333 putative PBP binding regions; other site 211110003334 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 211110003335 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 211110003336 ABC-ATPase subunit interface; other site 211110003337 dimer interface [polypeptide binding]; other site 211110003338 putative PBP binding regions; other site 211110003339 maltose O-acetyltransferase; Provisional; Region: PRK10092 211110003340 Maltose O-acetyltransferase (MAT) and Galactoside O-acetyltransferase (GAT): MAT and GAT catalyze the CoA-dependent acetylation of the 6-hydroxyl group of their respective sugar substrates. MAT acetylates maltose and glucose exclusively at the C6...; Region: LbH_MAT_GAT; cd03357 211110003341 active site 211110003342 substrate binding site [chemical binding]; other site 211110003343 trimer interface [polypeptide binding]; other site 211110003344 CoA binding site [chemical binding]; other site 211110003345 bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182 211110003346 RNA/DNA hybrid binding site [nucleotide binding]; other site 211110003347 active site 211110003348 GTPase YlqF; Reviewed; Region: rbgA; PRK09563 211110003349 Circularly permuted YlqF GTPase; Region: YlqF; cd01856 211110003350 GTP/Mg2+ binding site [chemical binding]; other site 211110003351 G4 box; other site 211110003352 G5 box; other site 211110003353 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 211110003354 G1 box; other site 211110003355 G1 box; other site 211110003356 GTP/Mg2+ binding site [chemical binding]; other site 211110003357 Switch I region; other site 211110003358 G2 box; other site 211110003359 G2 box; other site 211110003360 G3 box; other site 211110003361 G3 box; other site 211110003362 Switch II region; other site 211110003363 Switch II region; other site 211110003364 G5 box; other site 211110003365 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 211110003366 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 211110003367 Carbon starvation protein, predicted membrane protein [Signal transduction mechanisms]; Region: CstA; COG1966 211110003368 Carbon starvation protein CstA; Region: CstA; pfam02554 211110003369 C-terminal domain on CstA (DUF4161); Region: DUF4161; pfam13722 211110003370 two-component response regulator; Provisional; Region: PRK14084 211110003371 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 211110003372 active site 211110003373 phosphorylation site [posttranslational modification] 211110003374 intermolecular recognition site; other site 211110003375 dimerization interface [polypeptide binding]; other site 211110003376 LytTr DNA-binding domain; Region: LytTR; pfam04397 211110003377 Putative regulator of cell autolysis [Signal transduction mechanisms]; Region: LytS; COG3275 211110003378 5TMR of 5TMR-LYT; Region: 5TM-5TMR_LYT; pfam07694 211110003379 GAF domain; Region: GAF_3; pfam13492 211110003380 Histidine kinase; Region: His_kinase; pfam06580 211110003381 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 211110003382 ATP binding site [chemical binding]; other site 211110003383 Mg2+ binding site [ion binding]; other site 211110003384 G-X-G motif; other site 211110003385 Pseudogene, similar to C-terminal part ofDNA segregation ATPase, FtsK/SpoIIIE family 211110003386 similar to immunogenic secreted protein precursor (C-terminal part);unknown 211110003387 similar to immunogenic secreted protein precursor (internal part);unknown 211110003388 Domain of unknown function (DUF4176); Region: DUF4176; pfam13780 211110003389 type VII secretion effector, SACOL2603 family; Region: T7SS_SACOL2603; TIGR04197 211110003390 type VII secretion protein EssC, C-terminal domain; Region: T7_EssCb_Firm; TIGR03928 211110003391 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 211110003392 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 211110003393 DNA transporter; Region: FtsK_SpoIIIE_N; pfam12538 211110003394 RNA recognition motif (RRM) superfamily; Region: RRM_SF; cl17169 211110003395 type VII secretion protein EssB; Region: T7_EssB; TIGR03926 211110003396 WXG100 protein secretion system (Wss), protein YukC; Region: YukC; pfam10140 211110003397 WXG100 protein secretion system (Wss), protein YukD; Region: YukD; pfam08817 211110003398 type VII secretion protein EssA; Region: T7SS_EssA_Firm; TIGR03927 211110003399 type VII secretion protein EsaA, N-terminal domain; Region: T7_esaA_Nterm; TIGR03929 211110003400 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061 211110003401 WXG100 family type VII secretion target; Region: WXG100_ESAT6; TIGR03930 211110003402 Protein of unknown function (DUF2974); Region: DUF2974; pfam11187 211110003403 Lipase. Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is "interfacial activation", the process of...; Region: Lipase; cl14883 211110003404 nucleophilic elbow; other site 211110003405 catalytic triad; other site 211110003406 carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294 211110003407 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 211110003408 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 211110003409 Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787 211110003410 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 211110003411 ATP-grasp domain; Region: ATP-grasp_4; cl17255 211110003412 Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424 211110003413 IMP binding site; other site 211110003414 dimer interface [polypeptide binding]; other site 211110003415 interdomain contacts; other site 211110003416 partial ornithine binding site; other site 211110003417 carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564 211110003418 Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; smart01097 211110003419 Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744 211110003420 catalytic site [active] 211110003421 subunit interface [polypeptide binding]; other site 211110003422 aspartate carbamoyltransferase catalytic subunit; Provisional; Region: pyrB; PRK00856 211110003423 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 211110003424 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 211110003425 dihydroorotase; Validated; Region: pyrC; PRK09357 211110003426 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 211110003427 Dihydroorotase (DHOase), subgroup IIa; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This subgroup also contains proteins that lack the active site, like unc-33, a C; Region: DHOase_IIa; cd01317 211110003428 active site 211110003429 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 211110003430 active site 211110003431 Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725 211110003432 active site 211110003433 dimer interface [polypeptide binding]; other site 211110003434 Uncharacterized conserved protein [Function unknown]; Region: COG2966 211110003435 Protein of unknown function (DUF1212); Region: DUF1212; pfam06738 211110003436 Protein of unknown function (DUF3815); Region: DUF3815; pfam12821 211110003437 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 211110003438 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 211110003439 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 211110003440 ABC transporter; Region: ABC_tran_2; pfam12848 211110003441 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 211110003442 ATP cone domain; Region: ATP-cone; pfam03477 211110003443 aspartate-semialdehyde dehydrogenase; Provisional; Region: PRK14874 211110003444 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 211110003445 Fibrinogen binding protein; Region: Fibrinogen_BP; pfam08017 211110003446 LPXTG-motif cell wall anchor domain; Region: LPXTG_anchor; TIGR01167 211110003447 cardiolipin synthetase; Reviewed; Region: cls; PRK01642 211110003448 Putative catalytic domain, repeat 1, of Streptococcus mutans uncharacterized protein SMU_988 and similar proteins; Region: PLDc_SMU_988_like_1; cd09154 211110003449 putative active site [active] 211110003450 catalytic site [active] 211110003451 Putative catalytic domain, repeat 2, of Streptococcus mutans uncharacterized protein SMU_988 and similar proteins; Region: PLDc_SMU_988_like_2; cd09160 211110003452 putative active site [active] 211110003453 catalytic site [active] 211110003454 formate--tetrahydrofolate ligase; Provisional; Region: PRK13505 211110003455 Formyltetrahydrofolate synthetase (FTHFS) catalyzes the ATP-dependent activation of formate ion via its addition to the N10 position of tetrahydrofolate. FTHFS is a highly expressed key enzyme in both the Wood-Ljungdahl pathway of autotrophic CO2...; Region: FTHFS; cd00477 211110003456 Potassium binding sites [ion binding]; other site 211110003457 Cesium cation binding sites [ion binding]; other site 211110003458 Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095 211110003459 lipoyltransferase and lipoate-protein ligase; Region: lipoyltrans; TIGR00545 211110003460 Bacterial lipoate protein ligase C-terminus; Region: Lip_prot_lig_C; pfam10437 211110003461 NAD-dependent protein deacetylases, SIR2 family [Transcription]; Region: SIR2; COG0846 211110003462 SIR2 superfamily of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+; Region: SIR2; cl00195 211110003463 hypothetical protein; Provisional; Region: PRK04143 211110003464 ADP-ribose binding site [chemical binding]; other site 211110003465 Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848 211110003466 lipoyl attachment site [posttranslational modification]; other site 211110003467 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cd00347 211110003468 luciferase family oxidoreductase, group 1; Region: oxido_grp_1; TIGR03558 211110003469 probable F420-dependent oxidoreductase, MSMEG_4141 family; Region: F420_MSMEG_4141; TIGR03620 211110003470 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 211110003471 Old yellow enzyme (OYE)-related FMN binding domain, group 4. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a reducing agent with oxygens, quinones, and alpha,beta-unsaturated aldehydes and ketones, and can act as...; Region: OYE_like_4_FMN; cd04735 211110003472 putative active site [active] 211110003473 putative FMN binding site [chemical binding]; other site 211110003474 putative substrate binding site [chemical binding]; other site 211110003475 putative catalytic residue [active] 211110003476 Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095 211110003477 phosphopantothenate--cysteine ligase; Validated; Region: PRK06732 211110003478 phosphopantothenoylcysteine decarboxylase, streptococcal; Region: coaC_strep; TIGR02113 211110003479 Flavoprotein; Region: Flavoprotein; pfam02441 211110003480 Predicted membrane protein [Function unknown]; Region: COG4684 211110003481 phosphoglucomutase-2-like protein; Provisional; Region: PTZ00150 211110003482 This CD includes PGM2 (phosphoglucomutase 2) and PGM2L1 (phosphoglucomutase 2-like 1). The mammalian PGM2 is thought to be a phosphopentomutase that catalyzes the conversion of the nucleoside breakdown products, ribose-1-phosphate and...; Region: PGM2; cd05799 211110003483 active site 211110003484 substrate binding site [chemical binding]; other site 211110003485 metal binding site [ion binding]; metal-binding site 211110003486 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 211110003487 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 211110003488 ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254 211110003489 Walker A/P-loop; other site 211110003490 ATP binding site [chemical binding]; other site 211110003491 Q-loop/lid; other site 211110003492 ABC transporter signature motif; other site 211110003493 Walker B; other site 211110003494 D-loop; other site 211110003495 H-loop/switch region; other site 211110003496 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 211110003497 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 211110003498 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 211110003499 Walker A/P-loop; other site 211110003500 ATP binding site [chemical binding]; other site 211110003501 Q-loop/lid; other site 211110003502 ABC transporter signature motif; other site 211110003503 Walker B; other site 211110003504 D-loop; other site 211110003505 H-loop/switch region; other site 211110003506 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 211110003507 N-acetyl-D-glucosamine binding site [chemical binding]; other site 211110003508 catalytic residue [active] 211110003509 37-kD nucleoid-associated bacterial protein; Region: NA37; pfam04245 211110003510 serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011 211110003511 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378 211110003512 dimer interface [polypeptide binding]; other site 211110003513 active site 211110003514 glycine-pyridoxal phosphate binding site [chemical binding]; other site 211110003515 folate binding site [chemical binding]; other site 211110003516 Putative translation factor (SUA5) [Translation, ribosomal structure and biogenesis]; Region: SUA5; COG0009 211110003517 N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328 211110003518 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 211110003519 S-adenosylmethionine binding site [chemical binding]; other site 211110003520 peptide chain release factor 1; Validated; Region: prfA; PRK00591 211110003521 This domain is found in peptide chain release factors; Region: PCRF; smart00937 211110003522 RF-1 domain; Region: RF-1; pfam00472 211110003523 thymidine kinase; Provisional; Region: PRK04296 211110003524 4-oxalocrotonate tautomerase; Provisional; Region: PRK02289 211110003525 active site 1 [active] 211110003526 dimer interface [polypeptide binding]; other site 211110003527 hexamer interface [polypeptide binding]; other site 211110003528 active site 2 [active] 211110003529 Membrane-associated lipoprotein involved in thiamine biosynthesis [Coenzyme metabolism]; Region: ApbE; COG1477 211110003530 ApbE family; Region: ApbE; pfam02424 211110003531 Predicted flavoprotein [General function prediction only]; Region: COG0431 211110003532 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 211110003533 Predicted flavoprotein [General function prediction only]; Region: COG0431 211110003534 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 211110003535 PAS domain; Region: PAS_10; pfam13596 211110003536 Formate/nitrite transporter; Region: Form_Nir_trans; cl00927 211110003537 xanthine permease; Region: pbuX; TIGR03173 211110003538 Sulfate transporter family; Region: Sulfate_transp; pfam00916 211110003539 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 211110003540 active site 211110003541 Uncharacterized protein family (UPF0236); Region: UPF0236; pfam06782 211110003542 Integrase core domain; Region: rve; pfam00665 211110003543 ParB-like nuclease domain; Region: ParBc; pfam02195 211110003544 Stage 0 sporulation protein J (antagonist of Soj) containing ParB-like nuclease domain [Transcription]; Region: Spo0J; COG1475 211110003545 DNA modification methylase [DNA replication, recombination, and repair]; Region: COG0863 211110003546 DNA methylase; Region: N6_N4_Mtase; pfam01555 211110003547 Relaxase/Mobilisation nuclease domain; Region: Relaxase; pfam03432 211110003548 Protein of unknown function (DUF3991); Region: DUF3991; pfam13154 211110003549 Toprim-like; Region: Toprim_2; pfam13155 211110003550 Domain of unknown function (DUF955); Region: DUF955; pfam06114 211110003551 Type IV secretory system Conjugative DNA transfer; Region: T4SS-DNA_transf; pfam02534 211110003552 TraM recognition site of TraD and TraG; Region: TraG-D_C; pfam12696 211110003553 Protein of unknown function (DUF3801); Region: DUF3801; pfam12687 211110003554 Peptidase family M23; Region: Peptidase_M23; pfam01551 211110003555 Surface antigen [General function prediction only]; Region: COG3942 211110003556 CHAP domain; Region: CHAP; pfam05257 211110003557 AAA-like domain; Region: AAA_10; pfam12846 211110003558 PrgI family protein; Region: PrgI; pfam12666 211110003559 putative cross-wall-targeting lipoprotein signal; Region: strep_RK_lipo; TIGR03726 211110003560 adhesin isopeptide-forming domain, sspB-C2 type; Region: isopep_sspB_C2; TIGR04228 211110003561 A sub-family of peptidase family C39. Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various...; Region: Peptidase_C39A; cd02549 211110003562 putative active site [active] 211110003563 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 211110003564 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 211110003565 non-specific DNA binding site [nucleotide binding]; other site 211110003566 salt bridge; other site 211110003567 sequence-specific DNA binding site [nucleotide binding]; other site 211110003568 Replication initiator protein A (RepA) N-terminus; Region: RepA_N; pfam06970 211110003569 Domain of Unknown Function with PDB structure (DUF3850); Region: DUF3850; pfam12961 211110003570 guanosine 5'-monophosphate oxidoreductase; Provisional; Region: PRK05458 211110003571 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 211110003572 active site 211110003573 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 211110003574 Major Facilitator Superfamily; Region: MFS_1; pfam07690 211110003575 putative substrate translocation pore; other site 211110003576 K+ potassium transporter; Region: K_trans; cl15781 211110003577 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 211110003578 malonic semialdehyde reductase; Provisional; Region: PRK10538 211110003579 NAD(P) binding site [chemical binding]; other site 211110003580 active site 211110003581 phosphotransacetylase; Reviewed; Region: eutD; PRK09653 211110003582 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 211110003583 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cl09940 211110003584 RNA binding surface [nucleotide binding]; other site 211110003585 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 211110003586 active site 211110003587 inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK04885 211110003588 ATP-NAD kinase; Region: NAD_kinase; pfam01513 211110003589 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 211110003590 synthetase active site [active] 211110003591 NTP binding site [chemical binding]; other site 211110003592 metal binding site [ion binding]; metal-binding site 211110003593 Uncharacterized subgroup 1 of the CYTH-like superfamily; Region: CYTH-like_Pase_1; cd07762 211110003594 putative active site [active] 211110003595 putative metal binding residues [ion binding]; other site 211110003596 signature motif; other site 211110003597 putative triphosphate binding site [ion binding]; other site 211110003598 ribose-phosphate pyrophosphokinase; Provisional; Region: PRK02458 211110003599 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 211110003600 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 211110003601 active site 211110003602 Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104 211110003603 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 211110003604 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 211110003605 catalytic residue [active] 211110003606 Putative amino acid metabolism; Region: DUF1831; pfam08866 211110003607 redox-sensing transcriptional repressor Rex; Provisional; Region: PRK05472 211110003608 Putative DNA-binding protein N-terminus; Region: Put_DNA-bind_N; pfam06971 211110003609 CoA binding domain; Region: CoA_binding; pfam02629 211110003610 hypothetical protein; Reviewed; Region: PRK00024 211110003611 Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071 211110003612 MPN+ (JAMM) motif; other site 211110003613 Zinc-binding site [ion binding]; other site 211110003614 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 211110003615 6-phospho-beta-glucosidase; Reviewed; Region: arb; PRK09593 211110003616 beta-galactosidase; Region: BGL; TIGR03356 211110003617 NnaC (CMP-NeuNAc synthetase) _like subfamily of SGNH_hydrolases, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its...; Region: NnaC_like; cd01841 211110003618 active site 211110003619 catalytic triad [active] 211110003620 oxyanion hole [active] 211110003621 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 211110003622 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 211110003623 active site 211110003624 motif I; other site 211110003625 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 211110003626 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 211110003627 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 211110003628 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 211110003629 Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038 211110003630 ClC chloride channel EriC. This domain is found in the EriC chloride transporters that mediate the extreme acid resistance response in eubacteria and archaea. This response allows bacteria to survive in the acidic environments by decarboxylation-linked...; Region: EriC; cd01031 211110003631 Cl- selectivity filter; other site 211110003632 Cl- binding residues [ion binding]; other site 211110003633 pore gating glutamate residue; other site 211110003634 dimer interface [polypeptide binding]; other site 211110003635 H+/Cl- coupling transport residue; other site 211110003636 TrkA-C domain; Region: TrkA_C; pfam02080 211110003637 Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687 211110003638 Bacterial extracellular solute-binding protein; Region: SBP_bac_6; pfam13343 211110003639 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 211110003640 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 211110003641 dimer interface [polypeptide binding]; other site 211110003642 conserved gate region; other site 211110003643 putative PBP binding loops; other site 211110003644 ABC-ATPase subunit interface; other site 211110003645 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 211110003646 dimer interface [polypeptide binding]; other site 211110003647 conserved gate region; other site 211110003648 putative PBP binding loops; other site 211110003649 ABC-ATPase subunit interface; other site 211110003650 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 211110003651 ATP-binding cassette domain of the polyamine transporter; Region: ABC_PotA_N; cd03300 211110003652 Walker A/P-loop; other site 211110003653 ATP binding site [chemical binding]; other site 211110003654 Q-loop/lid; other site 211110003655 ABC transporter signature motif; other site 211110003656 Walker B; other site 211110003657 D-loop; other site 211110003658 H-loop/switch region; other site 211110003659 TOBE domain; Region: TOBE_2; pfam08402 211110003660 UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK13905 211110003661 FAD binding domain; Region: FAD_binding_4; pfam01565 211110003662 UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873 211110003663 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483 211110003664 catalytic center binding site [active] 211110003665 ATP binding site [chemical binding]; other site 211110003666 Dihydroneopterin aldolase (DHNA) and 7,8-dihydroneopterin triphosphate epimerase domain (DHNTPE); these enzymes have been designated folB and folX, respectively. Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and...; Region: DHNA_DHNTPE; cd00534 211110003667 homooctamer interface [polypeptide binding]; other site 211110003668 active site 211110003669 dihydropteroate synthase; Region: DHPS; TIGR01496 211110003670 DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739 211110003671 substrate binding pocket [chemical binding]; other site 211110003672 dimer interface [polypeptide binding]; other site 211110003673 inhibitor binding site; inhibition site 211110003674 GTP cyclohydrolase I (GTP-CH-I) catalyzes the conversion of GTP into dihydroneopterin triphosphate. The enzyme product is the precursor of tetrahydrofolate in eubacteria, fungi, and plants and of the folate analogs in methanogenic bacteria. In...; Region: GTP_cyclohydro1; cd00642 211110003675 homodecamer interface [polypeptide binding]; other site 211110003676 GTP cyclohydrolase I; Provisional; Region: PLN03044 211110003677 active site 211110003678 putative catalytic site residues [active] 211110003679 zinc binding site [ion binding]; other site 211110003680 GTP-CH-I/GFRP interaction surface; other site 211110003681 folylpolyglutamate synthase/dihydrofolate synthase; Region: folC; TIGR01499 211110003682 SNF2 Helicase protein; Region: DUF3670; pfam12419 211110003683 Predicted permeases [General function prediction only]; Region: RarD; COG2962 211110003684 homoserine kinase; Provisional; Region: PRK01212 211110003685 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 211110003686 homoserine dehydrogenase; Provisional; Region: PRK06349 211110003687 Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447 211110003688 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 211110003689 phosphopantothenoylcysteine decarboxylase / phosphopantothenate--cysteine ligase; Region: coaBC_dfp; TIGR00521 211110003690 similar to unknown protein C-terminal part;Unknown 211110003691 similar to glycine betaine transporter (C-terminal end);unknown 211110003692 BCCT family transporter; Region: BCCT; pfam02028 211110003693 NAD-dependent aldehyde dehydrogenases [Energy production and conversion]; Region: PutA; COG1012 211110003694 Mycobacterium tuberculosis succinate-semialdehyde dehydrogenase 1-like; Region: ALDH_SSADH1_GabD1; cd07100 211110003695 NAD(P) binding site [chemical binding]; other site 211110003696 catalytic residues [active] 211110003697 Predicted membrane protein [Function unknown]; Region: COG2855 211110003698 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 211110003699 non-specific DNA binding site [nucleotide binding]; other site 211110003700 salt bridge; other site 211110003701 sequence-specific DNA binding site [nucleotide binding]; other site 211110003702 Protein of unknown function (DUF3278); Region: DUF3278; pfam11683 211110003703 Peroxiredoxin (PRX) family, Atypical 2-cys PRX subfamily; composed of PRXs containing peroxidatic and resolving cysteines, similar to the homodimeric thiol specific antioxidant (TSA) protein also known as TRX-dependent thiol peroxidase (Tpx). Tpx is a...; Region: PRX_Atyp2cys; cd03014 211110003704 dimer interface [polypeptide binding]; other site 211110003705 catalytic triad [active] 211110003706 peroxidatic and resolving cysteines [active] 211110003707 DNA alkylation repair enzyme; Region: DNA_alkylation; pfam08713 211110003708 A new structural DNA glycosylase containing HEAT-like repeats; Region: AlkD_like_1; cd07064 211110003709 active site 211110003710 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 211110003711 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cl17915 211110003712 active site 211110003713 motif I; other site 211110003714 motif II; other site 211110003715 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 211110003716 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 211110003717 DNA-binding site [nucleotide binding]; DNA binding site 211110003718 TrkA-C domain; Region: TrkA_C; pfam02080 211110003719 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1302 211110003720 CsbD-like; Region: CsbD; pfam05532 211110003721 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1302 211110003722 Small integral membrane protein [Function unknown]; Region: COG5547 211110003723 Predicted membrane protein [Function unknown]; Region: COG2261 211110003724 Predicted membrane protein [Function unknown]; Region: COG2261 211110003725 ATP-dependent DNA helicase PcrA; Region: pcrA; TIGR01073 211110003726 Part of AAA domain; Region: AAA_19; pfam13245 211110003727 AAA domain; Region: AAA_12; pfam13087 211110003728 Family description; Region: UvrD_C_2; pfam13538 211110003729 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 211110003730 CoenzymeA binding site [chemical binding]; other site 211110003731 subunit interaction site [polypeptide binding]; other site 211110003732 PHB binding site; other site 211110003733 uracil transporter; Provisional; Region: PRK10720 211110003734 Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115 211110003735 amino acid carrier protein; Region: agcS; TIGR00835 211110003736 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 211110003737 Cation efflux family; Region: Cation_efflux; pfam01545 211110003738 Putative effector of murein hydrolase LrgA [General function prediction only]; Region: COG1380 211110003739 LrgB-like family; Region: LrgB; pfam04172 211110003740 Domain of Unknown Function with PDB structure (DUF3862); Region: DUF3862; pfam12978 211110003741 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 211110003742 sequence-specific DNA binding site [nucleotide binding]; other site 211110003743 salt bridge; other site 211110003744 Predicted transcriptional regulator [Transcription]; Region: COG2932 211110003745 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 211110003746 Catalytic site [active] 211110003747 Abi-like protein; Region: Abi_2; pfam07751 211110003748 tyrosine recombinase XerD; Region: recomb_XerD; TIGR02225 211110003749 phiLC3 phage and phage-related integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes various bacterial (mainly gram positive) and phage integrases, including those similar to Lactococcus...; Region: INT_phiLC3_C; cd01189 211110003750 Int/Topo IB signature motif; other site 211110003751 30S ribosomal protein S1; Reviewed; Region: rpsA; PRK06676 211110003752 S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687 211110003753 RNA binding site [nucleotide binding]; other site 211110003754 S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465 211110003755 RNA binding site [nucleotide binding]; other site 211110003756 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 211110003757 RNA binding site [nucleotide binding]; other site 211110003758 S1_RPS1_repeat_hs4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_hs4; cd05692 211110003759 RNA binding site [nucleotide binding]; other site 211110003760 Protein of unknown function (DUF2969); Region: DUF2969; pfam11184 211110003761 branched-chain amino acid aminotransferase; Provisional; Region: PRK13357 211110003762 BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557 211110003763 homodimer interface [polypeptide binding]; other site 211110003764 substrate-cofactor binding pocket; other site 211110003765 catalytic residue [active] 211110003766 DNA topoisomerase IV, A subunit, Gram-positive; Region: parC_Gpos; TIGR01061 211110003767 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 211110003768 CAP-like domain; other site 211110003769 active site 211110003770 primary dimer interface [polypeptide binding]; other site 211110003771 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 211110003772 DNA topoisomerase IV, B subunit, Gram-positive; Region: parE_Gpos; TIGR01058 211110003773 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 211110003774 Mg2+ binding site [ion binding]; other site 211110003775 G-X-G motif; other site 211110003776 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 211110003777 anchoring element; other site 211110003778 dimer interface [polypeptide binding]; other site 211110003779 ATP binding site [chemical binding]; other site 211110003780 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 211110003781 active site 211110003782 putative metal-binding site [ion binding]; other site 211110003783 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 211110003784 putative glycerol-3-phosphate acyltransferase PlsY; Provisional; Region: PRK00220 211110003785 Family 1 of Uracil-DNA glycosylase (UDG) enzymes; Region: UDG_F1; cd10027 211110003786 ligand binding site [chemical binding]; other site 211110003787 active site 211110003788 UGI interface [polypeptide binding]; other site 211110003789 catalytic site [active] 211110003790 CMP-NeuAc_Synthase activates N-acetylneuraminic acid by adding CMP moiety; Region: CMP-NeuAc_Synthase; cd02513 211110003791 ligand binding site; other site 211110003792 tetramer interface; other site 211110003793 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053 211110003794 active site 211110003795 catalytic triad [active] 211110003796 oxyanion hole [active] 211110003797 Putative Acyltransferase (AT), Left-handed parallel beta-Helix (LbH) domain; This group is composed of mostly uncharacterized proteins containing an N-terminal helical subdomain followed by a LbH domain. The alignment contains 6 turns, each containing...; Region: LbH_AT_putative; cd03360 211110003798 sugar O-acyltransferase, sialic acid O-acetyltransferase NeuD family; Region: NeuD_NnaD; TIGR03570 211110003799 putative trimer interface [polypeptide binding]; other site 211110003800 putative CoA binding site [chemical binding]; other site 211110003801 UDP-N-acetyl-D-glucosamine 2-epimerase, UDP-hydrolysing; Region: NeuC_NnaA; TIGR03568 211110003802 Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786 211110003803 active site 211110003804 homodimer interface [polypeptide binding]; other site 211110003805 N-acetylneuraminate synthase; Region: NeuB_NnaB; TIGR03569 211110003806 NeuB family; Region: NeuB; pfam03102 211110003807 C-terminal SAF domain of sialic acid synthetase; Region: SAF_NeuB_like; cd11615 211110003808 NeuB binding interface [polypeptide binding]; other site 211110003809 putative substrate binding site [chemical binding]; other site 211110003810 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 211110003811 Polysaccharide biosynthesis protein; Region: Polysacc_synt; pfam01943 211110003812 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 211110003813 Glycosyltransferase family 52; Region: Glyco_transf_52; pfam07922 211110003814 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 211110003815 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 211110003816 active site 211110003817 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 211110003818 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 211110003819 active site 211110003820 Glycosyltransferase family 28 C-terminal domain; Region: Glyco_tran_28_C; pfam04101 211110003821 Oligosaccharide biosynthesis protein Alg14 like; Region: Alg14; pfam08660 211110003822 exopolysaccharide biosynthesis polyprenyl glycosylphosphotransferase; Region: EPS_sugtrans; TIGR03025 211110003823 Bacterial sugar transferase; Region: Bac_transf; pfam02397 211110003824 capsular exopolysaccharide family; Region: eps_fam; TIGR01007 211110003825 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 211110003826 Chain length determinant protein; Region: Wzz; cl15801 211110003827 Capsular polysaccharide biosynthesis protein [Cell envelope biogenesis, outer membrane]; Region: COG3944 211110003828 Capsular polysaccharide biosynthesis protein [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: CapC; COG4464 211110003829 DNA polymerase processivity factor; Region: DNA_PPF; pfam02916 211110003830 Cell envelope-related transcriptional attenuator domain; Region: LytR_cpsA_psr; pfam03816 211110003831 Transcriptional regulator [Transcription]; Region: LysR; COG0583 211110003832 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 211110003833 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 211110003834 dimerization interface [polypeptide binding]; other site 211110003835 CRISPR/Cas system-associated protein Csm6; Region: Csm6_III-A; cl09873 211110003836 purine nucleoside phosphorylase; Reviewed; Region: deoD; PRK05819 211110003837 Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038 211110003838 Putative ClC chloride channel. Clc proteins are putative halogen ion (Cl-, Br- and I-) transporters found in eubacteria. They belong to the ClC superfamily of halogen ion channels, which share a unique double-barreled architecture and voltage-dependent...; Region: ClC_like; cd01033 211110003839 putative ion selectivity filter; other site 211110003840 putative pore gating glutamate residue; other site 211110003841 purine nucleoside phosphorylase; Provisional; Region: PRK08202 211110003842 Arsenate Reductase (ArsC) family, ArsC subfamily; arsenic reductases similar to that encoded by arsC on the R733 plasmid of Escherichia coli. E. coli ArsC catalyzes the reduction of arsenate [As(V)] to arsenite [As(III)], the first step in the...; Region: ArsC_ArsC; cd03034 211110003843 ArsC family; Region: ArsC; pfam03960 211110003844 catalytic residues [active] 211110003845 phosphopentomutase; Provisional; Region: PRK05362 211110003846 Metalloenzyme superfamily; Region: Metalloenzyme; pfam01676 211110003847 RPI_A: Ribose 5-phosphate isomerase type A (RPI_A) subfamily; RPI catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate, the first step of the non-oxidative branch of the pentose phosphate pathway. This reaction leads to the...; Region: RPI_A; cd01398 211110003848 tetramer (dimer of dimers) interface [polypeptide binding]; other site 211110003849 active site 211110003850 dimer interface [polypeptide binding]; other site 211110003851 Nuclear pore assembly and biogenesis; Region: Apq12; pfam12716 211110003852 Zinc-dependent metalloprotease, MMP_like subfamily. This group contains matrix metalloproteinases (MMPs), serralysins, and the astacin_like family of proteases; Region: ZnMc_MMP_like; cd04268 211110003853 active site 211110003854 S-formylglutathione hydrolase; Region: PLN02442 211110003855 Predicted esterase [General function prediction only]; Region: COG0627 211110003856 mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595 211110003857 Metallo-beta-lactamase superfamily; Region: Lactamase_B; pfam00753 211110003858 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 211110003859 ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: PhnK; COG1101 211110003860 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 211110003861 Walker A/P-loop; other site 211110003862 ATP binding site [chemical binding]; other site 211110003863 Q-loop/lid; other site 211110003864 ABC transporter signature motif; other site 211110003865 Walker B; other site 211110003866 D-loop; other site 211110003867 H-loop/switch region; other site 211110003868 Transmembrane subunit (TM) of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which are involved in the uptake of branched-chain amino acids (AAs), as well as TMs of transporters involved in the uptake of...; Region: TM_PBP1_branched-chain-AA_like; cd06574 211110003869 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 211110003870 TM-ABC transporter signature motif; other site 211110003871 Type I periplasmic ligand-binding domain of uncharacterized ABC-type transport systems that are predicted to be involved in the uptake of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_uncharacterized_transporter; cd06325 211110003872 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 211110003873 zinc binding site [ion binding]; other site 211110003874 putative ligand binding site [chemical binding]; other site 211110003875 Fibronectin-binding protein A N-terminus (FbpA); Region: FbpA; pfam05833 211110003876 Domain of unknown function (DUF814); Region: DUF814; pfam05670 211110003877 Alpha-acetolactate decarboxylase; Region: AAL_decarboxy; pfam03306 211110003878 acetolactate synthase; Reviewed; Region: PRK08617 211110003879 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 211110003880 PYR/PP interface [polypeptide binding]; other site 211110003881 dimer interface [polypeptide binding]; other site 211110003882 TPP binding site [chemical binding]; other site 211110003883 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 211110003884 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629 211110003885 TPP-binding site [chemical binding]; other site 211110003886 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 211110003887 binding surface 211110003888 TPR motif; other site 211110003889 Anaphase-promoting complex, cyclosome, subunit 3; Region: Apc3; pfam12895 211110003890 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 211110003891 Domain of unknown function DUF20; Region: UPF0118; pfam01594 211110003892 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_29; cd04688 211110003893 nudix motif; other site 211110003894 MutT homolog-1 (MTH1) is a member of the Nudix hydrolase superfamily. MTH1, the mammalian counterpart of MutT, hydrolyzes oxidized purine nucleoside triphosphates, such as 8-oxo-dGTP and 2-hydroxy-ATP, to monophosphates, thereby preventing the...; Region: MTH1; cd03427 211110003895 putative active site [active] 211110003896 nucleotide binding site [chemical binding]; other site 211110003897 nudix motif; other site 211110003898 putative metal binding site [ion binding]; other site 211110003899 Glycosaminoglycan (GAG) polysaccharide lyase family. This family consists of a group of secreted bacterial lyase enzymes capable of acting on glycosaminoglycans, such as hyaluronan and chondroitin, in the extracellular matrix of host tissues; Region: GAG_Lyase; cd01083 211110003900 substrate binding site [chemical binding]; other site 211110003901 catalytic residues [active] 211110003902 dTDP-D-glucose 4,6-dehydratase [Cell envelope biogenesis, outer membrane]; Region: RfbB; COG1088 211110003903 dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246 211110003904 NAD binding site [chemical binding]; other site 211110003905 substrate binding site [chemical binding]; other site 211110003906 homodimer interface [polypeptide binding]; other site 211110003907 active site 211110003908 dTDP-4-dehydrorhamnose 3,5-epimerase and related enzymes [Cell envelope biogenesis, outer membrane]; Region: RfbC; COG1898 211110003909 G1P_TT_short is the short form of glucose-1-phosphate thymidylyltransferase; Region: G1P_TT_short; cd02538 211110003910 glucose-1-phosphate thymidylyltransferase, short form; Region: rmlA; TIGR01207 211110003911 substrate binding site; other site 211110003912 tetramer interface; other site 211110003913 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 211110003914 Uncharacterized conserved protein [Function unknown]; Region: COG0327 211110003915 NIF3 (NGG1p interacting factor 3); Region: NIF3; pfam01784 211110003916 Predicted SAM-dependent methyltransferase [General function prediction only]; Region: COG2384 211110003917 Family of unknown function (DUF633); Region: DUF633; pfam04816 211110003918 Putative primosome component and related proteins [DNA replication, recombination, and repair]; Region: DnaD; COG3935 211110003919 Replication initiation and membrane attachment; Region: DnaB_2; pfam07261 211110003920 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 211110003921 active site 211110003922 KxYKxGKxW signal peptide; Region: KxYKxGKxW; TIGR03715 211110003923 Bacterial surface proteins containing Ig-like domains [Cell motility and secretion]; Region: COG5492 211110003924 Bacterial surface proteins containing Ig-like domains [Cell motility and secretion]; Region: COG5492 211110003925 Clostridial hydrophobic W; Region: ChW; pfam07538 211110003926 Clostridial hydrophobic W; Region: ChW; pfam07538 211110003927 Clostridial hydrophobic W; Region: ChW; pfam07538 211110003928 Bacterial surface proteins containing Ig-like domains [Cell motility and secretion]; Region: COG5492 211110003929 Clostridial hydrophobic W; Region: ChW; cl02763 211110003930 Clostridial hydrophobic W; Region: ChW; cl02763 211110003931 Clostridial hydrophobic W; Region: ChW; pfam07538 211110003932 Clostridial hydrophobic W; Region: ChW; cl02763 211110003933 Clostridial hydrophobic W; Region: ChW; pfam07538 211110003934 Clostridial hydrophobic W; Region: ChW; pfam07538 211110003935 GBS Bsp-like repeat; Region: GBS_Bsp-like; pfam08481 211110003936 A sub-family of peptidase family C39. Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various...; Region: Peptidase_C39A; cd02549 211110003937 putative active site [active] 211110003938 single-stranded-DNA-specific exonuclease RecJ; Region: recJ; TIGR00644 211110003939 DHH family; Region: DHH; pfam01368 211110003940 DHHA1 domain; Region: DHHA1; pfam02272 211110003941 Single-strand DNA-specific exonuclease, C terminal domain; Region: ssDNA-exonuc_C; pfam10141 211110003942 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 211110003943 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 211110003944 NAD(P) binding site [chemical binding]; other site 211110003945 active site 211110003946 ribonuclease Z; Region: RNase_Z; TIGR02651 211110003947 Galactose-1-phosphate uridyl transferase, N-terminal domain; Region: GalP_UDP_transf; pfam01087 211110003948 GTP-binding protein HflX; Region: GTP_HflX; TIGR03156 211110003949 GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167 211110003950 HflX GTPase family; Region: HflX; cd01878 211110003951 G1 box; other site 211110003952 GTP/Mg2+ binding site [chemical binding]; other site 211110003953 Switch I region; other site 211110003954 G2 box; other site 211110003955 G3 box; other site 211110003956 Switch II region; other site 211110003957 G4 box; other site 211110003958 G5 box; other site 211110003959 tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091 211110003960 tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324 211110003961 C4-dicarboxylate transporters of the Tellurite-resistance/Dicarboxylate Transporter (TDT) family; Region: TDT_C4-dicarb_trans; cd09325 211110003962 Tellurite resistance protein and related permeases [Inorganic ion transport and metabolism]; Region: TehA; COG1275 211110003963 gating phenylalanine in ion channel; other site 211110003964 YSIRK type signal peptide; Region: YSIRK_signal; pfam04650 211110003965 pullulanase, extracellular, Gram-positive; Region: pullulan_Gpos; TIGR02102 211110003966 Family 41 Carbohydrate-Binding Module from pullulanase-like enzymes; Region: CBM41_pullulanase; cd10315 211110003967 carbohydrate binding site [chemical binding]; other site 211110003968 Family 41 Carbohydrate-Binding Module from pullulanase-like enzymes; Region: CBM41_pullulanase; cd10315 211110003969 carbohydrate binding site [chemical binding]; other site 211110003970 Early set domain associated with the catalytic domain of pullulanase (also called dextrinase and alpha-dextrin endo-1,6-alpha glucosidase); Region: E_set_Pullulanase; cd02860 211110003971 Alpha amylase catalytic domain found in Pullulanase (also called dextrinase; alpha-dextrin endo-1,6-alpha glucosidase), limit dextrinase, and related proteins; Region: AmyAc_Pullulanase_LD-like; cd11341 211110003972 Ca binding site [ion binding]; other site 211110003973 active site 211110003974 catalytic site [active] 211110003975 hypothetical protein; Provisional; Region: PRK07329 211110003976 Polymerase and Histidinol Phosphatase domain; Region: PHP; cl17102 211110003977 active site 211110003978 Uncharacterized subfamily of Uracil-DNA glycosylases; Region: UDG_like_1; cd10033 211110003979 putative uracil binding site [chemical binding]; other site 211110003980 putative active site [active] 211110003981 dipeptidase PepV; Reviewed; Region: PRK07318 211110003982 M20 Peptidase Xaa-His dipeptidase (PepV) degrades hydrophobic dipeptides; Region: M20_PepV; cd03888 211110003983 active site 211110003984 metal binding site [ion binding]; metal-binding site 211110003985 Nitroreductase-like family 1. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_1; cd02137 211110003986 dimer interface [polypeptide binding]; other site 211110003987 FMN binding site [chemical binding]; other site 211110003988 Membrane domain of glycerophosphoryl diester phosphodiesterase; Region: GPDPase_memb; pfam10110 211110003989 Glycerophosphodiester phosphodiesterase domain of uncharacterized bacterial glycerophosphodiester phosphodiesterases; Region: GDPD_memb_like; cd08579 211110003990 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 211110003991 putative active site [active] 211110003992 catalytic site [active] 211110003993 putative metal binding site [ion binding]; other site 211110003994 excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558 211110003995 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 211110003996 GIY-YIG motif/motif A; other site 211110003997 active site 211110003998 catalytic site [active] 211110003999 putative DNA binding site [nucleotide binding]; other site 211110004000 metal binding site [ion binding]; metal-binding site 211110004001 UvrB/uvrC motif; Region: UVR; pfam02151 211110004002 UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459 211110004003 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1636 211110004004 multidrug efflux protein; Reviewed; Region: PRK01766 211110004005 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Vibrio cholerae NorM; Region: MATE_NorM_like; cd13131 211110004006 cation binding site [ion binding]; other site 211110004007 Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588 211110004008 dimer interface [polypeptide binding]; other site 211110004009 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 211110004010 Host cell surface-exposed lipoprotein; Region: Lipoprotein_Ltp; pfam07553 211110004011 Host cell surface-exposed lipoprotein; Region: Lipoprotein_Ltp; pfam07553 211110004012 Host cell surface-exposed lipoprotein; Region: Lipoprotein_Ltp; pfam07553 211110004013 Transposase; Region: HTH_Tnp_1; pfam01527 211110004014 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 211110004015 HTH-like domain; Region: HTH_21; pfam13276 211110004016 Integrase core domain; Region: rve; pfam00665 211110004017 Integrase core domain; Region: rve_3; pfam13683 211110004018 degenerate transposase 211110004019 degenerate transposase 211110004020 Degenerate transposase 211110004021 streptococcal histidine triad protein; Region: strep_his_triad; TIGR01363 211110004022 Streptococcal histidine triad protein; Region: Strep_his_triad; pfam04270 211110004023 Streptococcal histidine triad protein; Region: Strep_his_triad; pfam04270 211110004024 ABC-type metal ion transport system, periplasmic component/surface adhesin [Inorganic ion transport and metabolism]; Region: LraI; COG0803 211110004025 Metal binding protein AcdA. These proteins have been shown to function in the ABC uptake of Zn2+ and Mn2+ and in competence for genetic transformation and adhesion. The AcdA proteins belong to the TroA superfamily of helical backbone metal receptor...; Region: AdcA; cd01017 211110004026 metal binding site [ion binding]; metal-binding site 211110004027 Peptidase S8 family domain in Streptococcal C5a peptidases; Region: Peptidases_S8_C5a_Peptidase; cd07475 211110004028 putative active site [active] 211110004029 catalytic triad [active] 211110004030 PA_C5a_like: Protease-associated domain containing proteins like Streptococcus pyogenes C5a peptidase. This group contains various PA domain-containing proteins similar to S. pyogenes C5a, including, i) Vpr, a minor extracellular serine protease from...; Region: PA_C5a_like; cd02133 211110004031 PA/protease domain interface [polypeptide binding]; other site 211110004032 putative integrin binding motif; other site 211110004033 Peptidase S8 family domain in Streptococcal C5a peptidases; Region: Peptidases_S8_C5a_Peptidase; cd07475 211110004034 Fn3-like domain (DUF1034); Region: DUF1034; pfam06280 211110004035 C-terminal domain of CHU protein family; Region: CHU_C; cl17875 211110004036 Unknown 211110004037 Transposase; Region: HTH_Tnp_1; pfam01527 211110004038 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 211110004039 similar to transposase, C-terminal part;unknown 211110004040 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 211110004041 DNA polymerase III subunit epsilon; Validated; Region: PRK06807 211110004042 active site 211110004043 catalytic site [active] 211110004044 substrate binding site [chemical binding]; other site 211110004045 group I intron endonuclease; Region: grpIintron_endo; TIGR01453 211110004046 Intron encoded nuclease repeat motif; Region: IENR1; smart00497 211110004047 Bacteriophage abortive infection AbiH; Region: AbiH; pfam14253 211110004048 phiLC3 phage and phage-related integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes various bacterial (mainly gram positive) and phage integrases, including those similar to Lactococcus...; Region: INT_phiLC3_C; cd01189 211110004049 Int/Topo IB signature motif; other site 211110004050 Domain of unknown function (DUF3173); Region: DUF3173; pfam11372 211110004051 Plasmid replication protein; Region: Rep_2; pfam01719 211110004052 Unknown, truncated C-terminal part 211110004053 unknown, truncated C-terminal part 211110004054 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 211110004055 Separase, a protease involved in sister chromatid separation [Cell division and chromosome partitioning / Posttranslational modification, protein turnover, chaperones]; Region: ESP1; COG5155 211110004056 Eco57I restriction-modification methylase; Region: Eco57I; pfam07669 211110004057 TaqI-like C-terminal specificity domain; Region: TaqI_C; pfam12950 211110004058 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 211110004059 phiLC3 phage and phage-related integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes various bacterial (mainly gram positive) and phage integrases, including those similar to Lactococcus...; Region: INT_phiLC3_C; cd01189 211110004060 Int/Topo IB signature motif; other site 211110004061 Domain of unknown function (DUF3173); Region: DUF3173; pfam11372 211110004062 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 211110004063 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 211110004064 non-specific DNA binding site [nucleotide binding]; other site 211110004065 salt bridge; other site 211110004066 sequence-specific DNA binding site [nucleotide binding]; other site 211110004067 Aldose 1-epimerase, similar to Lactococcus lactis lacX; Region: Aldose_epim_lacX; cd09024 211110004068 active site 211110004069 catalytic residues [active] 211110004070 6-phospho-beta-galactosidase; Provisional; Region: PRK13511 211110004071 beta-galactosidase; Region: BGL; TIGR03356 211110004072 phosphotransferase system, lactose specific, IIC component; Region: lac_pts_IIC; TIGR00394 211110004073 Phosphotransferase system, EIIC; Region: PTS_EIIC; pfam02378 211110004074 PTS_IIB_lactose: subunit IIB of enzyme II (EII) of the lactose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS) found in Firmicutes as well as Actinobacteria. In this system, EII is a lactose-specific permease with two...; Region: PTS_IIB_lactose; cd05565 211110004075 active site 211110004076 P-loop; other site 211110004077 phosphorylation site [posttranslational modification] 211110004078 PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_lac; cd00215 211110004079 methionine cluster; other site 211110004080 active site 211110004081 phosphorylation site [posttranslational modification] 211110004082 metal binding site [ion binding]; metal-binding site 211110004083 CAT RNA binding domain; Region: CAT_RBD; smart01061 211110004084 transcriptional antiterminator BglG; Provisional; Region: PRK09772 211110004085 PRD domain; Region: PRD; pfam00874 211110004086 PRD domain; Region: PRD; pfam00874 211110004087 tagatose 1,6-diphosphate aldolase; Reviewed; Region: PRK12399 211110004088 1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164 211110004089 tagatose-6-phosphate kinase; Region: lacC; TIGR01231 211110004090 putative substrate binding site [chemical binding]; other site 211110004091 putative ATP binding site [chemical binding]; other site 211110004092 galactose-6-phosphate isomerase subunit LacB; Reviewed; Region: PRK08622 211110004093 galactose-6-phosphate isomerase subunit LacA; Reviewed; Region: PRK08621 211110004094 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 211110004095 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; pfam08220 211110004096 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 211110004097 Relaxase/Mobilisation nuclease domain; Region: Relaxase; pfam03432 211110004098 Lantibiotic streptin immunity protein; Region: Streptin-Immun; pfam11083 211110004099 Bacterial mobilisation protein (MobC); Region: MobC; pfam05713 211110004100 Part of AAA domain; Region: AAA_19; pfam13245 211110004101 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 211110004102 Family description; Region: UvrD_C_2; pfam13538 211110004103 AAA domain; Region: AAA_21; pfam13304 211110004104 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 211110004105 Walker A/P-loop; other site 211110004106 ATP binding site [chemical binding]; other site 211110004107 AAA domain; Region: AAA_21; pfam13304 211110004108 TOPRIM_OLD: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in bacterial and archaeal nucleases of the OLD (overcome lysogenization defect) family. The bacteriophage P2 OLD protein, which has DNase as well as...; Region: TOPRIM_OLD; cd01026 211110004109 putative active site [active] 211110004110 putative metal-binding site [ion binding]; other site 211110004111 Zeta toxin; Region: Zeta_toxin; pfam06414 211110004112 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4185 211110004113 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 211110004114 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 211110004115 non-specific DNA binding site [nucleotide binding]; other site 211110004116 salt bridge; other site 211110004117 sequence-specific DNA binding site [nucleotide binding]; other site 211110004118 CHC2 zinc finger; Region: zf-CHC2; cl17510 211110004119 Protein of unknown function (DUF3991); Region: DUF3991; pfam13154 211110004120 Toprim-like; Region: Toprim_2; pfam13155 211110004121 Methyltransferase domain; Region: Methyltransf_26; pfam13659 211110004122 DNA methylase [Transcription / DNA replication, recombination, and repair]; Region: COG4646 211110004123 SNF2 family N-terminal domain; Region: SNF2_N; pfam00176 211110004124 DNA methylase [Transcription / DNA replication, recombination, and repair]; Region: COG4646 211110004125 helicase superfamily c-terminal domain; Region: HELICc; smart00490 211110004126 putative cross-wall-targeting lipoprotein signal; Region: strep_RK_lipo; TIGR03726 211110004127 Glucan-binding protein C; Region: GbpC; pfam08363 211110004128 adhesin isopeptide-forming domain, sspB-C2 type; Region: isopep_sspB_C2; TIGR04228 211110004129 adhesin isopeptide-forming domain, sspB-C2 type; Region: isopep_sspB_C2; TIGR04228 211110004130 adhesin isopeptide-forming domain, sspB-C2 type; Region: isopep_sspB_C2; TIGR04228 211110004131 Domain of unknown function (DUF4095); Region: DUF4095; pfam13338 211110004132 Nucleotidyl transferase of unknown function (DUF1814); Region: DUF1814; pfam08843 211110004133 Peptidase family M23; Region: Peptidase_M23; pfam01551 211110004134 CHAP domain; Region: CHAP; pfam05257 211110004135 AAA-like domain; Region: AAA_10; pfam12846 211110004136 PrgI family protein; Region: PrgI; pfam12666 211110004137 AAA-like domain; Region: AAA_10; pfam12846 211110004138 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 211110004139 Walker A motif; other site 211110004140 ATP binding site [chemical binding]; other site 211110004141 Walker B motif; other site 211110004142 CAAX protease self-immunity; Region: Abi; pfam02517 211110004143 Protein of unknown function (DUF3491); Region: DUF3491; pfam11996 211110004144 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 211110004145 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315 211110004146 cofactor binding site; other site 211110004147 DNA binding site [nucleotide binding] 211110004148 substrate interaction site [chemical binding]; other site 211110004149 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315 211110004150 Replication initiator protein A (RepA) N-terminus; Region: RepA_N; pfam06970 211110004151 Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387 211110004152 core dimer interface [polypeptide binding]; other site 211110004153 L10 interface [polypeptide binding]; other site 211110004154 L11 interface [polypeptide binding]; other site 211110004155 putative EF-Tu interaction site [polypeptide binding]; other site 211110004156 putative EF-G interaction site [polypeptide binding]; other site 211110004157 Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797 211110004158 23S rRNA interface [nucleotide binding]; other site 211110004159 Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site 211110004160 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 211110004161 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 211110004162 Walker A motif; other site 211110004163 ATP binding site [chemical binding]; other site 211110004164 Walker B motif; other site 211110004165 arginine finger; other site 211110004166 UvrB/uvrC motif; Region: UVR; pfam02151 211110004167 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 211110004168 Walker A motif; other site 211110004169 ATP binding site [chemical binding]; other site 211110004170 Walker B motif; other site 211110004171 arginine finger; other site 211110004172 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 211110004173 homocysteine methyltransferase; Provisional; Region: mmuM; PRK09485 211110004174 Homocysteine S-methyltransferase; Region: S-methyl_trans; pfam02574 211110004175 S-methylmethionine transporter; Provisional; Region: PRK11387 211110004176 Protein of unknown function with HXXEE motif; Region: HXXEE; pfam13787 211110004177 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 211110004178 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 211110004179 YihA (EngB) GTPase family; Region: YihA_EngB; cd01876 211110004180 G1 box; other site 211110004181 GTP/Mg2+ binding site [chemical binding]; other site 211110004182 Switch I region; other site 211110004183 G2 box; other site 211110004184 G3 box; other site 211110004185 Switch II region; other site 211110004186 G4 box; other site 211110004187 G5 box; other site 211110004188 ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342 211110004189 ClpX C4-type zinc finger; Region: zf-C4_ClpX; pfam06689 211110004190 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 211110004191 Walker A motif; other site 211110004192 ATP binding site [chemical binding]; other site 211110004193 Walker B motif; other site 211110004194 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 211110004195 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 211110004196 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cd00209 211110004197 folate binding site [chemical binding]; other site 211110004198 NADP+ binding site [chemical binding]; other site 211110004199 thymidylate synthase; Reviewed; Region: thyA; PRK01827 211110004200 Thymidylate synthase and pyrimidine hydroxymethylase: Thymidylate synthase (TS) and deoxycytidylate hydroxymethylase (dCMP-HMase) are homologs that catalyze analogous alkylation of C5 of pyrimidine nucleotides. Both enzymes are involved in the...; Region: TS_Pyrimidine_HMase; cd00351 211110004201 dimerization interface [polypeptide binding]; other site 211110004202 active site 211110004203 "initiating" condensing enzymes are a subclass of decarboxylating condensing enzymes, including beta-ketoacyl [ACP] synthase, type III and polyketide synthases, type III, which include chalcone synthase and related enzymes. They are...; Region: init_cond_enzymes; cd00827 211110004204 3-hydroxy-3-methylglutaryl CoA synthase, prokaryotic clade; Region: HMG-CoA-S_prok; TIGR01835 211110004205 dimer interface [polypeptide binding]; other site 211110004206 active site 211110004207 Class II hydroxymethylglutaryl-coenzyme A (HMG-CoA) reductase (HMGR); Region: HMG-CoA_reductase_classII; cd00644 211110004208 homodimer interface [polypeptide binding]; other site 211110004209 catalytic residues [active] 211110004210 NAD binding site [chemical binding]; other site 211110004211 substrate binding pocket [chemical binding]; other site 211110004212 flexible flap; other site 211110004213 Domain of unknown function (DUF1836); Region: DUF1836; pfam08876 211110004214 Predicted membrane protein, hemolysin III homolog [General function prediction only]; Region: COG1272 211110004215 channel protein, hemolysin III family; Region: hlyIII; TIGR01065 211110004216 Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase [Lipid metabolism / General function prediction only]; Region: LCB5; COG1597 211110004217 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 211110004218 Predicted glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: ECM4; COG0435 211110004219 C-terminal, alpha helical domain of Class Omega-like Glutathione S-transferases; Region: GST_C_Omega_like; cd03190 211110004220 putative substrate binding pocket (H-site) [chemical binding]; other site 211110004221 N-terminal domain interface [polypeptide binding]; other site 211110004222 isopentenyl pyrophosphate isomerase; Provisional; Region: PRK05437 211110004223 Isopentenyl-diphosphate:dimethylallyl diphosphate isomerase type 2 (IDI-2) FMN-binding domain. Two types of IDIs have been characterized at present. The long known IDI-1 is only dependent on divalent metals for activity, whereas IDI-2 requires a metal; Region: IDI-2_FMN; cd02811 211110004224 homotetramer interface [polypeptide binding]; other site 211110004225 FMN binding site [chemical binding]; other site 211110004226 homodimer contacts [polypeptide binding]; other site 211110004227 putative active site [active] 211110004228 putative substrate binding site [chemical binding]; other site 211110004229 Mevalonate kinase [Lipid metabolism]; Region: ERG12; COG1577 211110004230 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 211110004231 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 211110004232 diphosphomevalonate decarboxylase; Region: mevDPdecarb; TIGR01240 211110004233 diphosphomevalonate decarboxylase; Region: PLN02407 211110004234 Mevalonate kinase [Lipid metabolism]; Region: ERG12; COG1577 211110004235 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 211110004236 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 211110004237 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 211110004238 dimer interface [polypeptide binding]; other site 211110004239 phosphorylation site [posttranslational modification] 211110004240 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 211110004241 ATP binding site [chemical binding]; other site 211110004242 Mg2+ binding site [ion binding]; other site 211110004243 G-X-G motif; other site 211110004244 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 211110004245 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 211110004246 active site 211110004247 phosphorylation site [posttranslational modification] 211110004248 intermolecular recognition site; other site 211110004249 dimerization interface [polypeptide binding]; other site 211110004250 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 211110004251 DNA binding site [nucleotide binding] 211110004252 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 211110004253 synthetase active site [active] 211110004254 NTP binding site [chemical binding]; other site 211110004255 metal binding site [ion binding]; metal-binding site 211110004256 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 211110004257 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 211110004258 ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254 211110004259 Walker A/P-loop; other site 211110004260 ATP binding site [chemical binding]; other site 211110004261 Q-loop/lid; other site 211110004262 ABC transporter signature motif; other site 211110004263 Walker B; other site 211110004264 D-loop; other site 211110004265 H-loop/switch region; other site 211110004266 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 211110004267 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 211110004268 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 211110004269 Walker A/P-loop; other site 211110004270 ATP binding site [chemical binding]; other site 211110004271 Q-loop/lid; other site 211110004272 ABC transporter signature motif; other site 211110004273 Walker B; other site 211110004274 D-loop; other site 211110004275 H-loop/switch region; other site 211110004276 Transcriptional regulators [Transcription]; Region: MarR; COG1846 211110004277 MarR family; Region: MarR_2; pfam12802 211110004278 5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737 211110004279 Bacillus subtilis YhcR endonuclease and related proteins, N-terminal metallophosphatase domain; Region: MPP_YhcR_N; cd07412 211110004280 putative active site [active] 211110004281 putative metal binding site [ion binding]; other site 211110004282 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 211110004283 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 211110004284 active site 211110004285 catalytic residues [active] 211110004286 metal binding site [ion binding]; metal-binding site 211110004287 glutamate dehydrogenase; Provisional; Region: PRK09414 211110004288 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 211110004289 NAD(P) binding domain of glutamate dehydrogenase, subgroup 2; Region: NAD_bind_2_Glu_DH; cd05313 211110004290 NAD(P) binding site [chemical binding]; other site 211110004291 Short repeat of unknown function (DUF308); Region: DUF308; cl15828 211110004292 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 211110004293 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 211110004294 ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254 211110004295 Walker A/P-loop; other site 211110004296 ATP binding site [chemical binding]; other site 211110004297 Q-loop/lid; other site 211110004298 ABC transporter signature motif; other site 211110004299 Walker B; other site 211110004300 D-loop; other site 211110004301 H-loop/switch region; other site 211110004302 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 211110004303 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 211110004304 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 211110004305 Walker A/P-loop; other site 211110004306 ATP binding site [chemical binding]; other site 211110004307 Q-loop/lid; other site 211110004308 ABC transporter signature motif; other site 211110004309 Walker B; other site 211110004310 D-loop; other site 211110004311 H-loop/switch region; other site 211110004312 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 211110004313 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 211110004314 Coenzyme A binding pocket [chemical binding]; other site 211110004315 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 211110004316 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 211110004317 Walker A/P-loop; other site 211110004318 ATP binding site [chemical binding]; other site 211110004319 Q-loop/lid; other site 211110004320 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 211110004321 ABC transporter; Region: ABC_tran_2; pfam12848 211110004322 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 211110004323 tRNA CCA-pyrophosphorylase; Provisional; Region: PRK13299 211110004324 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 211110004325 active site 211110004326 NTP binding site [chemical binding]; other site 211110004327 metal binding triad [ion binding]; metal-binding site 211110004328 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 211110004329 tRNA nucleotidyltransferase domain 2 putative; Region: tRNA_NucTran2_2; pfam13735 211110004330 EDD domain protein, DegV family; Region: DegV; TIGR00762 211110004331 Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645 211110004332 Protein of unknown function (DUF1149); Region: DUF1149; pfam06619 211110004333 Predicted membrane protein (DUF2127); Region: DUF2127; cl01785 211110004334 PTS system 2-O-a-mannosyl-D-glycerate specific transporter subunit IIABC; Provisional; Region: PRK09765 211110004335 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 211110004336 active site 211110004337 phosphorylation site [posttranslational modification] 211110004338 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569 211110004339 active site 211110004340 P-loop; other site 211110004341 phosphorylation site [posttranslational modification] 211110004342 Phosphotransferase system, fructose-specific IIC component [Carbohydrate transport and metabolism]; Region: FruA; COG1299 211110004343 Fructose-1-phosphate kinase and related fructose-6-phosphate kinase (PfkB) [Carbohydrate transport and metabolism]; Region: FruK; COG1105 211110004344 1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164 211110004345 putative substrate binding site [chemical binding]; other site 211110004346 putative ATP binding site [chemical binding]; other site 211110004347 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 211110004348 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 211110004349 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 211110004350 FemAB family; Region: FemAB; pfam02388 211110004351 YSIRK type signal peptide; Region: YSIRK_signal; cl04650 211110004352 Bacterial SH3 domain; Region: SH3_5; pfam08460 211110004353 Bacterial SH3 domain; Region: SH3_5; pfam08460 211110004354 GBS Bsp-like repeat; Region: GBS_Bsp-like; pfam08481 211110004355 Bacterial SH3 domain; Region: SH3_5; pfam08460 211110004356 Bacterial SH3 domain; Region: SH3_5; pfam08460 211110004357 2-dehydropantoate 2-reductase; Reviewed; Region: PRK06522 211110004358 Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558 211110004359 Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546 211110004360 Predicted membrane protein, putative toxin regulator [General function prediction only]; Region: PfoR; COG3641 211110004361 Phosphotransferase system, EIIC; Region: PTS_EIIC_2; pfam13303 211110004362 Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492 211110004363 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 211110004364 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 211110004365 tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026 211110004366 16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK00122 211110004367 RimM N-terminal domain; Region: RimM; pfam01782 211110004368 M protein trans-acting positive regulator (MGA) HTH domain; Region: HTH_Mga; pfam08280 211110004369 Mga helix-turn-helix domain; Region: Mga; pfam05043 211110004370 M protein trans-acting positive regulator (MGA) PRD domain; Region: PRD_Mga; pfam08270 211110004371 Predicted RNA-binding protein (contains KH domain) [General function prediction only]; Region: COG1837 211110004372 KH domain; Region: KH_4; pfam13083 211110004373 G-X-X-G motif; other site 211110004374 30S ribosomal protein S16; Reviewed; Region: rpsP; PRK00040 211110004375 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 211110004376 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 211110004377 FtsX-like permease family; Region: FtsX; pfam02687 211110004378 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 211110004379 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 211110004380 Walker A/P-loop; other site 211110004381 ATP binding site [chemical binding]; other site 211110004382 Q-loop/lid; other site 211110004383 ABC transporter signature motif; other site 211110004384 Walker B; other site 211110004385 D-loop; other site 211110004386 H-loop/switch region; other site 211110004387 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 211110004388 HlyD family secretion protein; Region: HlyD_3; pfam13437 211110004389 ATP-grasp domain; Region: ATP-grasp_4; cl17255 211110004390 Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787 211110004391 carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12838 211110004392 Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; pfam00988 211110004393 Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744 211110004394 catalytic site [active] 211110004395 subunit interface [polypeptide binding]; other site 211110004396 Pyrimidine operon attenuation protein/uracil phosphoribosyltransferase [Nucleotide transport and metabolism]; Region: PyrR; COG2065 211110004397 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 211110004398 active site 211110004399 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 211110004400 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 211110004401 RNA binding surface [nucleotide binding]; other site 211110004402 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 211110004403 active site 211110004404 lipoprotein signal peptidase; Provisional; Region: PRK14797 211110004405 Transcriptional regulator [Transcription]; Region: LysR; COG0583 211110004406 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 211110004407 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 211110004408 dimerization interface [polypeptide binding]; other site 211110004409 50S ribosomal protein L27; Validated; Region: rpmA; PRK05435 211110004410 Protein of unknown function (DUF464); Region: DUF464; pfam04327 211110004411 50S ribosomal protein L21; Validated; Region: rplU; PRK05573 211110004412 Bacterial capsule synthesis protein PGA_cap; Region: PGA_cap; smart00854 211110004413 CapA and related proteins, metallophosphatase domain; Region: MPP_CapA; cd07381 211110004414 putative active site [active] 211110004415 putative metal binding site [ion binding]; other site 211110004416 thiamine biosynthesis protein ThiI; Provisional; Region: PRK01565 211110004417 THUMP domain of thiamine biosynthesis protein ThiI; Region: THUMP_ThiI; cd11716 211110004418 ThiI is required for thiazole synthesis in the thiamine biosynthesis pathway. It belongs to the Adenosine Nucleotide Hydrolysis suoerfamily and predicted to bind to Adenosine nucleotide; Region: ThiI; cd01712 211110004419 Ligand Binding Site [chemical binding]; other site 211110004420 Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104 211110004421 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 211110004422 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 211110004423 catalytic residue [active] 211110004424 glutathione reductase; Validated; Region: PRK06116 211110004425 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 211110004426 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 211110004427 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 211110004428 hypothetical protein; Provisional; Region: PRK13676 211110004429 Chorismate synthase [Amino acid transport and metabolism]; Region: AroC; COG0082 211110004430 Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304 211110004431 Tetramer interface [polypeptide binding]; other site 211110004432 active site 211110004433 FMN-binding site [chemical binding]; other site 211110004434 Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195 211110004435 active site 211110004436 dimer interface [polypeptide binding]; other site 211110004437 metal binding site [ion binding]; metal-binding site 211110004438 3-dehydroquinate dehydratase [Amino acid transport and metabolism]; Region: AroD; COG0710 211110004439 Type I 3-dehydroquinase, (3-dehydroquinate dehydratase or DHQase); Region: DHQase_I; cd00502 211110004440 active site 211110004441 catalytic residue [active] 211110004442 dimer interface [polypeptide binding]; other site 211110004443 Predicted SAM-dependent methyltransferases [General function prediction only]; Region: COG1092 211110004444 Middle domain of the SAM-dependent methyltransferase RlmI and related proteins; Region: RlmI_M_like; cd11572 211110004445 putative RNA binding site [nucleotide binding]; other site 211110004446 Methyltransferase domain; Region: Methyltransf_26; pfam13659 211110004447 Phosphoglycerol transferase and related proteins, alkaline phosphatase superfamily [Cell envelope biogenesis, outer membrane]; Region: MdoB; COG1368 211110004448 Sulfatase; Region: Sulfatase; pfam00884 211110004449 Ribosomal protein L20; Region: Ribosomal_L20; cd07026 211110004450 23S rRNA binding site [nucleotide binding]; other site 211110004451 L21 binding site [polypeptide binding]; other site 211110004452 L13 binding site [polypeptide binding]; other site 211110004453 50S ribosomal protein L35; Reviewed; Region: rpmI; PRK00172 211110004454 translation initiation factor IF-3; Reviewed; Region: infC; PRK00028 211110004455 Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198 211110004456 Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707 211110004457 cytidylate kinase; Provisional; Region: cmk; PRK00023 211110004458 Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020 211110004459 CMP-binding site; other site 211110004460 The sites determining sugar specificity; other site 211110004461 Ferredoxin [Energy production and conversion]; Region: Fer; COG1141 211110004462 peptidase T; Region: peptidase-T; TIGR01882 211110004463 M20 Peptidase T specifically cleaves tripeptides; Region: M20_peptT; cd03892 211110004464 metal binding site [ion binding]; metal-binding site 211110004465 dimer interface [polypeptide binding]; other site 211110004466 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 211110004467 Stage V sporulation protein B, also known as Stage III sporulation protein F, and related proteins; Region: MATE_SpoVB_like; cd13124 211110004468 UDP-N-acetylmuramoylalanyl-D-glutamate--L-lysine ligase; Provisional; Region: PRK14022 211110004469 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 211110004470 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 211110004471 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 211110004472 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 211110004473 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 211110004474 Walker A/P-loop; other site 211110004475 ATP binding site [chemical binding]; other site 211110004476 Q-loop/lid; other site 211110004477 ABC transporter signature motif; other site 211110004478 Walker B; other site 211110004479 D-loop; other site 211110004480 H-loop/switch region; other site 211110004481 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 211110004482 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 211110004483 intersubunit interface [polypeptide binding]; other site 211110004484 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 211110004485 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 211110004486 ABC-ATPase subunit interface; other site 211110004487 dimer interface [polypeptide binding]; other site 211110004488 putative PBP binding regions; other site 211110004489 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 211110004490 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 211110004491 ABC-ATPase subunit interface; other site 211110004492 dimer interface [polypeptide binding]; other site 211110004493 putative PBP binding regions; other site 211110004494 Domain of unknown function (DUF1803); Region: DUF1803; pfam08820 211110004495 Domain of unknown function (DUF1803); Region: DUF1803; pfam08820 211110004496 putative manganese-dependent inorganic pyrophosphatase; Provisional; Region: PRK05427 211110004497 DHH family; Region: DHH; pfam01368 211110004498 DHHA2 domain; Region: DHHA2; pfam02833 211110004499 pyruvate formate-lyase 1-activating enzyme; Region: PFLA; TIGR02493 211110004500 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 211110004501 FeS/SAM binding site; other site 211110004502 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 211110004503 Domain of unknown function DUF21; Region: DUF21; pfam01595 211110004504 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 211110004505 Transporter associated domain; Region: CorC_HlyC; smart01091 211110004506 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 211110004507 S-adenosylmethionine binding site [chemical binding]; other site 211110004508 Predicted Fe-S oxidoreductase [General function prediction only]; Region: COG1242 211110004509 PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392 211110004510 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 211110004511 active site 211110004512 Predicted membrane protein [Function unknown]; Region: COG3601 211110004513 Protein of unknown function (DUF3816); Region: DUF3816; pfam12822 211110004514 Cna protein B-type domain; Region: Cna_B; pfam05738 211110004515 Sortase C (SrtC) or subfamily-3 sortases are membrane cysteine transpeptidases found in Gram-positive bacteria that anchor surface proteins to peptidoglycans of the bacterial cell wall envelope. This involves a transpeptidation reaction in which the...; Region: Sortase_C_3; cd05827 211110004516 active site 211110004517 catalytic site [active] 211110004518 Sortase C (SrtC) or subfamily-3 sortases are membrane cysteine transpeptidases found in Gram-positive bacteria that anchor surface proteins to peptidoglycans of the bacterial cell wall envelope. This involves a transpeptidation reaction in which the...; Region: Sortase_C_3; cd05827 211110004519 active site 211110004520 catalytic site [active] 211110004521 fimbrial isopeptide formation D2 domain; Region: RrgB_K2N_iso_D2; TIGR04226 211110004522 Cna protein B-type domain; Region: Cna_B; pfam05738 211110004523 Cna protein B-type domain; Region: Cna_B; pfam05738 211110004524 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 211110004525 metal ion-dependent adhesion site (MIDAS); other site 211110004526 Cna protein B-type domain; Region: Cna_B; pfam05738 211110004527 M protein trans-acting positive regulator (MGA) HTH domain; Region: HTH_Mga; pfam08280 211110004528 Mga helix-turn-helix domain; Region: Mga; pfam05043 211110004529 M protein trans-acting positive regulator (MGA) PRD domain; Region: PRD_Mga; pfam08270 211110004530 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 211110004531 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 211110004532 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 211110004533 L-rhamnosyltransferase; Region: rhamnosyltran; TIGR01556 211110004534 active site 211110004535 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 211110004536 Polysaccharide biosynthesis protein; Region: Polysacc_synt; pfam01943 211110004537 Predicted membrane protein (DUF2142); Region: DUF2142; pfam09913 211110004538 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 211110004539 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 211110004540 active site 211110004541 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 211110004542 Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_d; cd04196 211110004543 Probable Catalytic site; other site 211110004544 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 211110004545 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 211110004546 NAD(P) binding site [chemical binding]; other site 211110004547 active site 211110004548 CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516 211110004549 substrate binding site; other site 211110004550 dimer interface; other site 211110004551 LicD family; Region: LicD; cl01378 211110004552 Uncharacterized conserved protein (DUF2304); Region: DUF2304; cl01034 211110004553 DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179 211110004554 Ligand binding site; other site 211110004555 Putative Catalytic site; other site 211110004556 DXD motif; other site 211110004557 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 211110004558 Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_d; cd04196 211110004559 Probable Catalytic site; other site 211110004560 This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_6; cd04955 211110004561 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 211110004562 dTDP-6-deoxy-L-lyxo-4-hexulose reductase and related proteins, extended (e) SDRs; Region: dTDP_HR_like_SDR_e; cd05254 211110004563 RmlD substrate binding domain; Region: RmlD_sub_bind; pfam04321 211110004564 NADP binding site [chemical binding]; other site 211110004565 active site 211110004566 putative substrate binding site [chemical binding]; other site 211110004567 Predicted metal-sulfur cluster biosynthetic enzyme [General function prediction only]; Region: PaaD; COG2151 211110004568 RNA polymerase sigma factor RpoD; Validated; Region: PRK09210 211110004569 Sigma-70 factor, region 1.1; Region: Sigma70_r1_1; pfam03979 211110004570 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 211110004571 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 211110004572 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 211110004573 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 211110004574 DNA binding residues [nucleotide binding] 211110004575 DNA primase; Validated; Region: dnaG; PRK05667 211110004576 CHC2 zinc finger; Region: zf-CHC2; pfam01807 211110004577 DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275 211110004578 TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364 211110004579 active site 211110004580 metal binding site [ion binding]; metal-binding site 211110004581 interdomain interaction site; other site 211110004582 DnaB-helicase binding domain of primase; Region: DnaB_bind; pfam10410 211110004583 Large-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscL; COG1970 211110004584 large-conductance mechanosensitive channel; Reviewed; Region: mscL; PRK00567 211110004585 30S ribosomal protein S21; Reviewed; Region: rpsU; PRK00270 211110004586 Flagellin N-methylase; Region: FliB; pfam03692 211110004587 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 211110004588 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 211110004589 substrate binding pocket [chemical binding]; other site 211110004590 membrane-bound complex binding site; other site 211110004591 hinge residues; other site 211110004592 Ammonium Transporter Family; Region: Ammonium_transp; cl03012 211110004593 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 211110004594 putative rhodanese-related sulfurtransferase; Provisional; Region: PRK00142 211110004595 Member of the Rhodanese Homology Domain superfamily. This CD includes Escherichia coli YceA, Bacillus subtilis YbfQ, and similar uncharacterized proteins; Region: RHOD_YceA; cd01518 211110004596 active site residue [active] 211110004597 Protein of unknown function (DUF3650); Region: DUF3650; pfam12368 211110004598 Sugar phosphate permease [Carbohydrate transport and metabolism]; Region: UhpC; COG2271 211110004599 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 211110004600 putative substrate translocation pore; other site 211110004601 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 211110004602 glycogen/starch/alpha-glucan phosphorylases; Region: P_ylase; TIGR02093 211110004603 4-alpha-glucanotransferase; Provisional; Region: PRK14508 211110004604 Transcriptional regulators [Transcription]; Region: PurR; COG1609 211110004605 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 211110004606 DNA binding site [nucleotide binding] 211110004607 domain linker motif; other site 211110004608 Ligand-binding domain of uncharacterized transcription regulator ycjW which is a member of the LacI-GalR family repressors; Region: PBP1_ycjW_transcription_regulator_like; cd06294 211110004609 putative dimerization interface [polypeptide binding]; other site 211110004610 putative ligand binding site [chemical binding]; other site 211110004611 Maltose-binding periplasmic proteins/domains [Carbohydrate transport and metabolism]; Region: MalE; COG2182 211110004612 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 211110004613 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 211110004614 dimer interface [polypeptide binding]; other site 211110004615 conserved gate region; other site 211110004616 putative PBP binding loops; other site 211110004617 ABC-ATPase subunit interface; other site 211110004618 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 211110004619 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 211110004620 dimer interface [polypeptide binding]; other site 211110004621 conserved gate region; other site 211110004622 putative PBP binding loops; other site 211110004623 ABC-ATPase subunit interface; other site 211110004624 amino acid/peptide transporter (Peptide:H+ symporter), bacterial; Region: yjdL_sub1_fam; TIGR00924 211110004625 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 211110004626 putative substrate translocation pore; other site 211110004627 POT family; Region: PTR2; cl17359 211110004628 MutT homolog-1 (MTH1) is a member of the Nudix hydrolase superfamily. MTH1, the mammalian counterpart of MutT, hydrolyzes oxidized purine nucleoside triphosphates, such as 8-oxo-dGTP and 2-hydroxy-ATP, to monophosphates, thereby preventing the...; Region: MTH1; cd03427 211110004629 putative active site [active] 211110004630 nucleotide binding site [chemical binding]; other site 211110004631 nudix motif; other site 211110004632 putative metal binding site [ion binding]; other site 211110004633 accessory Sec system glycosyltransferase GtfB; Region: TIGR02919 211110004634 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 211110004635 accessory Sec system glycosylation protein GtfA; Region: TIGR02918 211110004636 This family is most closely related to the GT1 family of glycosyltransferases and is named after gtfA in Streptococcus gordonii, where it plays a role in the O-linked glycosylation of GspB, a cell surface glycoprotein involved in platelet binding. In...; Region: GT1_gtfA_like; cd04949 211110004637 accessory Sec system translocase SecA2; Region: secA2; TIGR03714 211110004638 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 211110004639 ATP binding site [chemical binding]; other site 211110004640 putative Mg++ binding site [ion binding]; other site 211110004641 SecA preprotein cross-linking domain; Region: SecA_PP_bind; pfam01043 211110004642 accessory Sec system protein Asp3; Region: acc_sec_asp3; TIGR03711 211110004643 accessory Sec system protein Asp2; Region: acc_sec_asp2; TIGR03712 211110004644 accessory Sec system protein Asp1; Region: acc_sec_asp1; TIGR03713 211110004645 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 211110004646 preprotein translocase subunit SecY; Reviewed; Region: secY; PRK12417 211110004647 SecY translocase; Region: SecY; pfam00344 211110004648 glycosyltransferase, SP_1767 family; Region: glyco_access_1; TIGR03728 211110004649 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 211110004650 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 211110004651 active site 211110004652 Glycosyl transferase family 8; Region: Glyco_transf_8; pfam01501 211110004653 A4GalT_like proteins catalyze the addition of galactose or glucose residues to the lipooligosaccharide (LOS) or lipopolysaccharide (LPS) of the bacterial cell surface; Region: GT8_A4GalT_like; cd04194 211110004654 Ligand binding site; other site 211110004655 metal-binding site 211110004656 A4GalT_like proteins catalyze the addition of galactose or glucose residues to the lipooligosaccharide (LOS) or lipopolysaccharide (LPS) of the bacterial cell surface; Region: GT8_A4GalT_like; cd04194 211110004657 Glycosyl transferase family 8; Region: Glyco_transf_8; pfam01501 211110004658 Ligand binding site; other site 211110004659 metal-binding site 211110004660 A4GalT_like proteins catalyze the addition of galactose or glucose residues to the lipooligosaccharide (LOS) or lipopolysaccharide (LPS) of the bacterial cell surface; Region: GT8_A4GalT_like; cd04194 211110004661 Glycosyl transferase family 8; Region: Glyco_transf_8; pfam01501 211110004662 Ligand binding site; other site 211110004663 metal-binding site 211110004664 beta-1,6-galactofuranosyltransferase; Provisional; Region: PRK09814 211110004665 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 211110004666 KxYKxGKxW signal peptide; Region: KxYKxGKxW; TIGR03715 211110004667 serine-rich repeat adhesion glycoprotein AST domain; Region: ser_adhes_Nterm; TIGR04224 211110004668 C-terminus of bacterial fibrinogen-binding adhesin; Region: SdrG_C_C; pfam10425 211110004669 M protein trans-acting positive regulator (MGA) HTH domain; Region: HTH_Mga; pfam08280 211110004670 Mga helix-turn-helix domain; Region: Mga; pfam05043 211110004671 M protein trans-acting positive regulator (MGA) PRD domain; Region: PRD_Mga; pfam08270 211110004672 excinuclease ABC subunit B; Provisional; Region: PRK05298 211110004673 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 211110004674 ATP binding site [chemical binding]; other site 211110004675 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 211110004676 nucleotide binding region [chemical binding]; other site 211110004677 ATP-binding site [chemical binding]; other site 211110004678 Ultra-violet resistance protein B; Region: UvrB; pfam12344 211110004679 CAAX protease self-immunity; Region: Abi; pfam02517 211110004680 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 211110004681 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 211110004682 substrate binding pocket [chemical binding]; other site 211110004683 membrane-bound complex binding site; other site 211110004684 hinge residues; other site 211110004685 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 211110004686 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 211110004687 substrate binding pocket [chemical binding]; other site 211110004688 membrane-bound complex binding site; other site 211110004689 hinge residues; other site 211110004690 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 211110004691 dimer interface [polypeptide binding]; other site 211110004692 conserved gate region; other site 211110004693 putative PBP binding loops; other site 211110004694 ABC-ATPase subunit interface; other site 211110004695 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 211110004696 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 211110004697 Walker A/P-loop; other site 211110004698 ATP binding site [chemical binding]; other site 211110004699 Q-loop/lid; other site 211110004700 ABC transporter signature motif; other site 211110004701 Walker B; other site 211110004702 D-loop; other site 211110004703 H-loop/switch region; other site 211110004704 GTPase CgtA; Reviewed; Region: obgE; PRK12297 211110004705 GTP1/OBG; Region: GTP1_OBG; pfam01018 211110004706 Obg GTPase; Region: Obg; cd01898 211110004707 G1 box; other site 211110004708 GTP/Mg2+ binding site [chemical binding]; other site 211110004709 Switch I region; other site 211110004710 G2 box; other site 211110004711 G3 box; other site 211110004712 Switch II region; other site 211110004713 G4 box; other site 211110004714 G5 box; other site 211110004715 Domain of unknown function (DUF1967); Region: DUF1967; pfam09269 211110004716 Thermophilic metalloprotease (M29); Region: Peptidase_M29; pfam02073 211110004717 Leucyl aminopeptidase (aminopeptidase T) [Amino acid transport and metabolism]; Region: AmpS; COG2309 211110004718 amidase; Provisional; Region: PRK06529 211110004719 Amidase; Region: Amidase; cl11426 211110004720 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 211110004721 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 211110004722 RNA binding surface [nucleotide binding]; other site 211110004723 Pseudouridine synthase, Escherichia coli RsuA like; Region: PseudoU_synth_RsuA; cd02553 211110004724 active site 211110004725 uracil binding [chemical binding]; other site 211110004726 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 211110004727 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 211110004728 active site 211110004729 catalytic tetrad [active] 211110004730 NAD(P)H:FMN oxidoreductase family. This domain catalyzes the reduction of flavin, nitrocompound, quinones and azo compounds using NADH or NADPH as an electron donor. The enzyme is a homodimer, and each monomer binds a FMN as co-factor. This family...; Region: NfsB_like_nitroreductase; cd02149 211110004731 dimer interface [polypeptide binding]; other site 211110004732 FMN binding site [chemical binding]; other site 211110004733 Glyoxalase I catalyzes the isomerization of the hemithioacetal, formed by a 2-oxoaldehyde and glutathione, to S-D-lactoylglutathione; Region: Glyoxalase_I; cd07233 211110004734 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 211110004735 dimer interface [polypeptide binding]; other site 211110004736 active site 211110004737 metal binding site [ion binding]; metal-binding site 211110004738 glutathione binding site [chemical binding]; other site 211110004739 undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714 211110004740 Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187 211110004741 Ligand binding site; other site 211110004742 Putative Catalytic site; other site 211110004743 DXD motif; other site 211110004744 Amino acid permease; Region: AA_permease_2; pfam13520 211110004745 Spore germination protein; Region: Spore_permease; cl17796 211110004746 Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294 211110004747 SmpB-tmRNA interface; other site 211110004748 ribonuclease R; Region: RNase_R; TIGR02063 211110004749 Ribonuclease B OB domain; Region: OB_RNB; pfam08206 211110004750 RNB domain; Region: RNB; pfam00773 211110004751 S1_RNase_R: RNase R C-terminal S1 domain. RNase R is a processive 3' to 5' exoribonuclease, which is a homolog of RNase II. RNase R degrades RNA with secondary structure having a 3' overhang of at least 7 nucleotides. RNase R and PNPase...; Region: S1_RNase_R; cd04471 211110004752 RNA binding site [nucleotide binding]; other site 211110004753 preprotein translocase subunit SecG; Reviewed; Region: secG; PRK06870 211110004754 drug efflux system protein MdtG; Provisional; Region: PRK09874 211110004755 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 211110004756 putative substrate translocation pore; other site 211110004757 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 211110004758 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 211110004759 Walker A/P-loop; other site 211110004760 ATP binding site [chemical binding]; other site 211110004761 Q-loop/lid; other site 211110004762 ABC transporter signature motif; other site 211110004763 Walker B; other site 211110004764 D-loop; other site 211110004765 H-loop/switch region; other site 211110004766 Dephospho-CoA kinase [Coenzyme metabolism]; Region: CoaE; COG0237 211110004767 Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022 211110004768 CoA-binding site [chemical binding]; other site 211110004769 ATP-binding [chemical binding]; other site 211110004770 formamidopyrimidine/5-formyluracil/ 5-hydroxymethyluracil DNA glycosylase; Validated; Region: PRK01103 211110004771 N-terminal domain of Escherichia coli Fpg1/MutM and related bacterial DNA glycosylases; Region: EcFpg-like_N; cd08966 211110004772 DNA binding site [nucleotide binding] 211110004773 catalytic residue [active] 211110004774 H2TH interface [polypeptide binding]; other site 211110004775 putative catalytic residues [active] 211110004776 turnover-facilitating residue; other site 211110004777 intercalation triad [nucleotide binding]; other site 211110004778 8OG recognition residue [nucleotide binding]; other site 211110004779 putative reading head residues; other site 211110004780 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 211110004781 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 211110004782 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 211110004783 sequence-specific DNA binding site [nucleotide binding]; other site 211110004784 salt bridge; other site 211110004785 transcriptional activator, Rgg/GadR/MutR family, C-terminal domain; Region: RGG_Cterm; TIGR01716 211110004786 Transglutaminase/protease-like homologues; Region: TGc; smart00460 211110004787 unknown 211110004788 CAAX protease self-immunity; Region: Abi; pfam02517 211110004789 GTPase Era; Reviewed; Region: era; PRK00089 211110004790 E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163 211110004791 G1 box; other site 211110004792 GTP/Mg2+ binding site [chemical binding]; other site 211110004793 Switch I region; other site 211110004794 G2 box; other site 211110004795 Switch II region; other site 211110004796 G3 box; other site 211110004797 G4 box; other site 211110004798 G5 box; other site 211110004799 KH domain; Region: KH_2; pfam07650 211110004800 Diacylglycerol kinase [Cell envelope biogenesis, outer membrane]; Region: DgkA; COG0818 211110004801 metal-binding heat shock protein; Provisional; Region: PRK00016 211110004802 O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315 211110004803 Leucine carboxyl methyltransferase; Region: LCM; pfam04072 211110004804 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 211110004805 nudix motif; other site 211110004806 Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702 211110004807 PhoH-like protein; Region: PhoH; pfam02562 211110004808 myosin-cross-reactive antigen; Provisional; Region: PRK13977 211110004809 hypothetical protein; Provisional; Region: PRK13672 211110004810 methionine sulfoxide reductase A; Provisional; Region: PRK14054 211110004811 Predicted RNA-bindining protein (contains S1 and HTH domains) [General function prediction only]; Region: COG2996 211110004812 S1 domain; Region: S1_2; pfam13509 211110004813 Ribosomal protein S1-like RNA-binding domain; Region: S1; smart00316 211110004814 ribosome recycling factor; Reviewed; Region: frr; PRK00083 211110004815 Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation. Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520 211110004816 hinge region; other site 211110004817 UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254 211110004818 putative nucleotide binding site [chemical binding]; other site 211110004819 uridine monophosphate binding site [chemical binding]; other site 211110004820 homohexameric interface [polypeptide binding]; other site 211110004821 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 211110004822 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 211110004823 Walker A/P-loop; other site 211110004824 ATP binding site [chemical binding]; other site 211110004825 Q-loop/lid; other site 211110004826 ABC transporter signature motif; other site 211110004827 Walker B; other site 211110004828 D-loop; other site 211110004829 H-loop/switch region; other site 211110004830 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 211110004831 nickel import ATP-binding protein NikD; Region: nickel_nikD; TIGR02770 211110004832 Walker A/P-loop; other site 211110004833 ATP binding site [chemical binding]; other site 211110004834 Q-loop/lid; other site 211110004835 ABC transporter signature motif; other site 211110004836 Walker B; other site 211110004837 D-loop; other site 211110004838 H-loop/switch region; other site 211110004839 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 211110004840 nickel ABC transporter, permease subunit NikC; Region: nickel_nikC; TIGR02790 211110004841 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 211110004842 dimer interface [polypeptide binding]; other site 211110004843 conserved gate region; other site 211110004844 putative PBP binding loops; other site 211110004845 ABC-ATPase subunit interface; other site 211110004846 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 211110004847 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 211110004848 dimer interface [polypeptide binding]; other site 211110004849 conserved gate region; other site 211110004850 putative PBP binding loops; other site 211110004851 ABC-ATPase subunit interface; other site 211110004852 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 211110004853 The substrate-binding component of an ABC-type nickel import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA; cd08489 211110004854 substrate binding site [chemical binding]; other site 211110004855 Ribosomal protein L1. The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA. In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403 211110004856 mRNA/rRNA interface [nucleotide binding]; other site 211110004857 50S ribosomal protein L11; Validated; Region: rplK; PRK00140 211110004858 Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349 211110004859 23S rRNA interface [nucleotide binding]; other site 211110004860 L7/L12 interface [polypeptide binding]; other site 211110004861 putative thiostrepton binding site; other site 211110004862 L25 interface [polypeptide binding]; other site 211110004863 Major Facilitator Superfamily; Region: MFS_1; pfam07690 211110004864 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 211110004865 putative substrate translocation pore; other site 211110004866 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 211110004867 M20 Peptidase Aminoacylase 1 family; Region: M20_Acy1; cd03886 211110004868 metal binding site [ion binding]; metal-binding site 211110004869 dimer interface [polypeptide binding]; other site 211110004870 Transcriptional regulator [Transcription]; Region: LysR; COG0583 211110004871 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 211110004872 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 211110004873 dimerization interface [polypeptide binding]; other site 211110004874 Protein of unknown function (DUF3397); Region: DUF3397; pfam11877 211110004875 aminodeoxychorismate synthase; Provisional; Region: PRK07508 211110004876 chorismate binding enzyme; Region: Chorismate_bind; cl10555 211110004877 substrate-cofactor binding pocket; other site 211110004878 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 211110004879 Aminotransferase class IV; Region: Aminotran_4; pfam01063 211110004880 pyridoxal 5'-phosphate binding site [chemical binding]; other site 211110004881 DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674 211110004882 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 211110004883 Ftsk gamma domain; Region: Ftsk_gamma; pfam09397 211110004884 Peptidyl-prolyl cis-trans isomerase (rotamase) - cyclophilin family [Posttranslational modification, protein turnover, chaperones]; Region: PpiB; COG0652 211110004885 active site 211110004886 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 211110004887 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 211110004888 ABC-ATPase subunit interface; other site 211110004889 dimer interface [polypeptide binding]; other site 211110004890 putative PBP binding regions; other site 211110004891 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 211110004892 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 211110004893 ABC-type metal ion transport system, periplasmic component/surface adhesin [Inorganic ion transport and metabolism]; Region: LraI; COG0803 211110004894 Metal binding protein PsaA. These proteins have been shown to function as initial receptors in ABC transport of Mn2+ and as surface adhesins in some eubacterial species. They belong to the TroA superfamily of periplasmic metal binding proteins that...; Region: PsaA; cd01137 211110004895 metal binding site [ion binding]; metal-binding site 211110004896 Mn-dependent transcriptional regulator [Transcription]; Region: TroR; COG1321 211110004897 Iron dependent repressor, N-terminal DNA binding domain; Region: Fe_dep_repress; pfam01325 211110004898 Iron dependent repressor, metal binding and dimerisation domain; Region: Fe_dep_repr_C; pfam02742 211110004899 FeoA domain; Region: FeoA; pfam04023 211110004900 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Validated; Region: PRK05584 211110004901 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Region: MTA/SAH-Nsdase; TIGR01704 211110004902 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 211110004903 dimer interface [polypeptide binding]; other site 211110004904 ADP-ribose binding site [chemical binding]; other site 211110004905 active site 211110004906 nudix motif; other site 211110004907 metal binding site [ion binding]; metal-binding site 211110004908 bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase; Provisional; Region: glmU; PRK14354 211110004909 N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540 211110004910 Substrate binding site; other site 211110004911 Mg++ binding site; other site 211110004912 N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353 211110004913 active site 211110004914 substrate binding site [chemical binding]; other site 211110004915 CoA binding site [chemical binding]; other site 211110004916 Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588 211110004917 dimer interface [polypeptide binding]; other site 211110004918 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 211110004919 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_16; cd07263 211110004920 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 211110004921 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 211110004922 ASC-1 homology or ASCH domain, a small beta-barrel domain found in all three kingdoms of life. ASCH resembles the RNA-binding PUA domain and may also interact with RNA. ASCH has been proposed to function as an RNA-binding domain during coactivation; Region: ASCH; cl01020 211110004923 ASC-1 homology or ASCH domain, a small beta-barrel domain found in all three kingdoms of life. ASCH resembles the RNA-binding PUA domain and may also interact with RNA. ASCH has been proposed to function as an RNA-binding domain during coactivation; Region: ASCH; cl01020 211110004924 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK06550 211110004925 classical (c) SDRs; Region: SDR_c; cd05233 211110004926 NAD(P) binding site [chemical binding]; other site 211110004927 active site 211110004928 Protein of unknown function (DUF2829); Region: DUF2829; pfam11195 211110004929 YbaK-like. The YbaK family of deacylase domains includes the INS amino acid-editing domain of the bacterial class II prolyl tRNA synthetase (ProRS), and it's trans-acting homologs, YbaK, ProX, and PrdX. The primary function of INS is to hydrolyze...; Region: YbaK_like; cl00022 211110004930 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 211110004931 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 211110004932 Coenzyme A binding pocket [chemical binding]; other site 211110004933 similar to unknown proteins (C-terminal end);unknown 211110004934 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 211110004935 CESA_like is the cellulose synthase superfamily; Region: CESA_like; cd06423 211110004936 DXD motif; other site 211110004937 CotH protein; Region: CotH; pfam08757 211110004938 Uncharacterized membrane protein [Function unknown]; Region: SapB; COG1285 211110004939 Polyphosphate(polyP) polymerase domain of yeast vacuolar transport chaperone (VTC) proteins VTC-2, -3 and- 4, and similar proteins; Region: PolyPPase_VTC_like; cd07750 211110004940 active site 211110004941 acceptor-phosphate pocket; other site 211110004942 polyP binding site; other site 211110004943 substrate binding site [chemical binding]; other site 211110004944 dimer interface [polypeptide binding]; other site 211110004945 putative metal binding residues [ion binding]; other site 211110004946 Branched-chain amino acid transport protein; Region: Branch_AA_trans; cl00547 211110004947 methionyl-tRNA synthetase; Reviewed; Region: PRK12267 211110004948 catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814 211110004949 active site 211110004950 HIGH motif; other site 211110004951 KMSKS motif; other site 211110004952 Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957 211110004953 tRNA binding surface [nucleotide binding]; other site 211110004954 anticodon binding site; other site 211110004955 tRNA-binding-domain-containing Escherichia coli methionyl-tRNA synthetase (EcMetRS)-like proteins. This family includes EcMetRS and Aquifex aeolicus Trbp111 (AaTrbp111). This domain has general tRNA binding properties. MetRS aminoacylates methionine...; Region: tRNA_bind_EcMetRS_like; cd02800 211110004956 dimer interface [polypeptide binding]; other site 211110004957 putative tRNA-binding site [nucleotide binding]; other site 211110004958 tellurite resistance protein TehB; Provisional; Region: PRK12335 211110004959 Domain of unknown function (DUF1971); Region: DUF1971; pfam09313 211110004960 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 211110004961 S-adenosylmethionine binding site [chemical binding]; other site 211110004962 Protein of unknown function (DUF1275); Region: DUF1275; pfam06912 211110004963 Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455 211110004964 Alpha/beta hydrolase of unknown function (DUF915); Region: DUF915; pfam06028 211110004965 Human Ape1-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: Ape1-like_AP-endo; cd09087 211110004966 active site 211110004967 putative catalytic site [active] 211110004968 DNA binding site [nucleotide binding] 211110004969 putative phosphate binding site [ion binding]; other site 211110004970 metal binding site A [ion binding]; metal-binding site 211110004971 AP binding site [nucleotide binding]; other site 211110004972 metal binding site B [ion binding]; metal-binding site 211110004973 Arsenate Reductase (ArsC) family, unknown subfamily; uncharacterized proteins containing a CXXC motif with similarity to thioredoxin (TRX)-fold arsenic reductases, ArsC. Proteins containing a redox active CXXC motif like TRX and glutaredoxin (GRX)...; Region: ArsC_like; cd03036 211110004974 ArsC family; Region: ArsC; pfam03960 211110004975 putative ArsC-like catalytic residues; other site 211110004976 putative TRX-like catalytic residues [active] 211110004977 Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350 211110004978 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 211110004979 DNA binding site [nucleotide binding] 211110004980 active site 211110004981 Putative D-3-Phosphoglycerate Dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_like_3; cd12174 211110004982 putative ligand binding site [chemical binding]; other site 211110004983 Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111 211110004984 putative NAD binding site [chemical binding]; other site 211110004985 putative catalytic site [active] 211110004986 C-terminal ACT (regulatory) domain of D-3-Phosphoglycerate Dehydrogenase (3PGDH) found in fungi and bacteria; Region: ACT_3PGDH; cd04901 211110004987 L-serine binding site [chemical binding]; other site 211110004988 ACT domain interface; other site 211110004989 3-phosphoserine/phosphohydroxythreonine aminotransferase; Provisional; Region: PRK05355 211110004990 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 211110004991 catalytic residue [active] 211110004992 Uncharacterized protein involved in copper resistance [Inorganic ion transport and metabolism]; Region: CutC; COG3142 211110004993 Predicted methyltransferases [General function prediction only]; Region: COG0313 211110004994 Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648 211110004995 putative SAM binding site [chemical binding]; other site 211110004996 putative homodimer interface [polypeptide binding]; other site 211110004997 DNA replication intiation control protein YabA; Reviewed; Region: PRK13169 211110004998 DNA polymerase III subunit delta'; Validated; Region: PRK07276 211110004999 DNA polymerase III subunit delta'; Validated; Region: PRK08485 211110005000 thymidylate kinase; Validated; Region: tmk; PRK00698 211110005001 Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672 211110005002 TMP-binding site; other site 211110005003 ATP-binding site [chemical binding]; other site 211110005004 FOG: CBS domain [General function prediction only]; Region: COG0517 211110005005 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the acetoin utilization proteins in bacteria. Acetoin is a product of fermentative metabolism in many prokaryotic and eukaryotic microorganisms. They produce...; Region: CBS_pair_ACT_assoc2; cd04585 211110005006 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 211110005007 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 211110005008 Walker A/P-loop; other site 211110005009 ATP binding site [chemical binding]; other site 211110005010 Q-loop/lid; other site 211110005011 ABC transporter signature motif; other site 211110005012 Walker B; other site 211110005013 D-loop; other site 211110005014 H-loop/switch region; other site 211110005015 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 211110005016 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 211110005017 Walker A/P-loop; other site 211110005018 ATP binding site [chemical binding]; other site 211110005019 Q-loop/lid; other site 211110005020 ABC transporter signature motif; other site 211110005021 Walker B; other site 211110005022 D-loop; other site 211110005023 H-loop/switch region; other site 211110005024 ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177 211110005025 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 211110005026 TM-ABC transporter signature motif; other site 211110005027 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 211110005028 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 211110005029 TM-ABC transporter signature motif; other site 211110005030 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 211110005031 Type I periplasmic ligand-binding domain of uncharacterized ABC (Atpase Binding Cassette)-type active transport systems that are predicted to be involved in uptake of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_ligand_binding_like_12; cd06347 211110005032 putative ligand binding site [chemical binding]; other site 211110005033 hypothetical protein; Provisional; Region: PRK02302 211110005034 Clp protease; Region: CLP_protease; pfam00574 211110005035 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 211110005036 oligomer interface [polypeptide binding]; other site 211110005037 active site residues [active] 211110005038 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 211110005039 active site 211110005040 Bifunctional PLP-dependent enzyme with beta-cystathionase and maltose regulon repressor activities [Amino acid transport and metabolism]; Region: MalY; COG1168 211110005041 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 211110005042 pyridoxal 5'-phosphate binding site [chemical binding]; other site 211110005043 homodimer interface [polypeptide binding]; other site 211110005044 catalytic residue [active] 211110005045 Predicted rRNA methylase (SpoU class) [Translation, ribosomal structure and biogenesis]; Region: CspR; COG0219 211110005046 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 211110005047 potassium transporter peripheral membrane component; Reviewed; Region: trkA; PRK09496 211110005048 TrkA-N domain; Region: TrkA_N; pfam02254 211110005049 TrkA-C domain; Region: TrkA_C; pfam02080 211110005050 TrkA-N domain; Region: TrkA_N; pfam02254 211110005051 TrkA-C domain; Region: TrkA_C; pfam02080 211110005052 Trk-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: TrkG; COG0168 211110005053 potassium uptake protein, TrkH family; Region: 2a38; TIGR00933 211110005054 hypothetical protein; Validated; Region: PRK00041 211110005055 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 211110005056 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 211110005057 RNA binding surface [nucleotide binding]; other site 211110005058 Pseudouridine synthases, RsuA subfamily; Region: PseudoU_synth_RsuA_like; cd02870 211110005059 active site 211110005060 segregation and condensation protein B; Reviewed; Region: scpB; PRK00135 211110005061 segregation and condensation protein A; Reviewed; Region: scpA; PRK00104 211110005062 site-specific tyrosine recombinase XerD-like protein; Reviewed; Region: xerD; PRK02436 211110005063 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 211110005064 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 211110005065 DNA binding site [nucleotide binding] 211110005066 Int/Topo IB signature motif; other site 211110005067 active site 211110005068 catalytic residues [active] 211110005069 FOG: CBS domain [General function prediction only]; Region: COG0517 211110005070 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_30; cd04643 211110005071 Escherichia coli YfcE and related proteins, metallophosphatase domain; Region: MPP_YfcE; cd00841 211110005072 active site 211110005073 metal binding site [ion binding]; metal-binding site 211110005074 homotetramer interface [polypeptide binding]; other site 211110005075 putative deoxyribonucleotide triphosphate pyrophosphatase/unknown domain fusion protein; Reviewed; Region: PRK02491 211110005076 NTPase/HAM1. This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515 211110005077 active site 211110005078 dimerization interface [polypeptide binding]; other site 211110005079 glutamate racemase; Provisional; Region: PRK00865 211110005080 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3763 211110005081 Predicted small molecule binding protein (contains 3H domain) [General function prediction only]; Region: COG1827 211110005082 HTH domain; Region: HTH_11; pfam08279 211110005083 3H domain; Region: 3H; pfam02829 211110005084 Integral membrane protein, interacts with FtsH [General function prediction only]; Region: COG0670 211110005085 Bacterial BAX inhibitor (BI)-1/YccA-like proteins; Region: BI-1-like_bacterial; cd10432 211110005086 Predicted HD superfamily hydrolase [General function prediction only]; Region: COG1418 211110005087 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 211110005088 substrate binding site [chemical binding]; other site 211110005089 activation loop (A-loop); other site 211110005090 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 211110005091 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; smart00967 211110005092 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 211110005093 acylphosphatase; Provisional; Region: PRK14434 211110005094 OxaA-like protein precursor; Provisional; Region: PRK02463 211110005095 membrane protein insertase, YidC/Oxa1 family, C-terminal domain; Region: yidC_oxa1_cterm; TIGR03592 211110005096 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 211110005097 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 211110005098 dimer interface [polypeptide binding]; other site 211110005099 conserved gate region; other site 211110005100 putative PBP binding loops; other site 211110005101 ABC-ATPase subunit interface; other site 211110005102 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 211110005103 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 211110005104 substrate binding pocket [chemical binding]; other site 211110005105 membrane-bound complex binding site; other site 211110005106 hinge residues; other site 211110005107 amidase; Provisional; Region: PRK06529 211110005108 Amidase; Region: Amidase; cl11426 211110005109 transcription elongation factor GreA; Reviewed; Region: greA; PRK00226 211110005110 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 211110005111 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 211110005112 Aminodeoxychorismate lyase [Coenzyme transport and metabolism]; Region: COG1559 211110005113 proteins similar to Escherichia coli yceG; Region: yceG_like; cd08010 211110005114 dimerization interface [polypeptide binding]; other site 211110005115 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 211110005116 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 211110005117 Coenzyme A binding pocket [chemical binding]; other site 211110005118 UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421 211110005119 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 211110005120 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 211110005121 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 211110005122 SWIM zinc finger; Region: SWIM; pfam04434 211110005123 Bacterial SNF2 helicase associated; Region: SNF2_assoc; pfam08455 211110005124 SNF2 family N-terminal domain; Region: SNF2_N; pfam00176 211110005125 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 211110005126 ATP binding site [chemical binding]; other site 211110005127 putative Mg++ binding site [ion binding]; other site 211110005128 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 211110005129 nucleotide binding region [chemical binding]; other site 211110005130 ATP-binding site [chemical binding]; other site 211110005131 GTP-binding protein Der; Reviewed; Region: PRK00093 211110005132 EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894 211110005133 G1 box; other site 211110005134 GTP/Mg2+ binding site [chemical binding]; other site 211110005135 Switch I region; other site 211110005136 G2 box; other site 211110005137 Switch II region; other site 211110005138 G3 box; other site 211110005139 G4 box; other site 211110005140 G5 box; other site 211110005141 EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895 211110005142 G1 box; other site 211110005143 GTP/Mg2+ binding site [chemical binding]; other site 211110005144 Switch I region; other site 211110005145 G2 box; other site 211110005146 G3 box; other site 211110005147 Switch II region; other site 211110005148 G4 box; other site 211110005149 G5 box; other site 211110005150 primosomal protein DnaI; Reviewed; Region: PRK08939 211110005151 Primosomal protein DnaI N-terminus; Region: DnaI_N; pfam07319 211110005152 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 211110005153 Walker A motif; other site 211110005154 ATP binding site [chemical binding]; other site 211110005155 Walker B motif; other site 211110005156 Replication initiation/membrane attachment protein [DNA replication, recombination, and repair]; Region: DnaB; COG3611 211110005157 Replication initiation and membrane attachment; Region: DnaB_2; cl12121 211110005158 transcriptional regulator NrdR; Validated; Region: nrdR; PRK00464 211110005159 Transcription factor S-II (TFIIS); Region: TFIIS_C; cl02609 211110005160 ATP cone domain; Region: ATP-cone; pfam03477 211110005161 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 211110005162 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 211110005163 dimerization interface [polypeptide binding]; other site 211110005164 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 211110005165 dimer interface [polypeptide binding]; other site 211110005166 phosphorylation site [posttranslational modification] 211110005167 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 211110005168 ATP binding site [chemical binding]; other site 211110005169 Mg2+ binding site [ion binding]; other site 211110005170 G-X-G motif; other site 211110005171 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 211110005172 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 211110005173 active site 211110005174 phosphorylation site [posttranslational modification] 211110005175 intermolecular recognition site; other site 211110005176 dimerization interface [polypeptide binding]; other site 211110005177 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 211110005178 DNA binding site [nucleotide binding] 211110005179 Uncharacterized ACR, COG1399; Region: DUF177; cl00616 211110005180 heat shock protein HtpX; Provisional; Region: PRK04897 211110005181 Uncharacterized conserved protein [Function unknown]; Region: LemA; COG1704 211110005182 Predicted S-adenosylmethionine-dependent methyltransferase involved in bacterial cell division [Cell envelope biogenesis, outer membrane]; Region: GidB; COG0357 211110005183 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 211110005184 S-adenosylmethionine binding site [chemical binding]; other site 211110005185 potassium uptake protein, TrkH family; Region: 2a38; TIGR00933 211110005186 Trk-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: TrkG; COG0168 211110005187 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 211110005188 TrkA-N domain; Region: TrkA_N; pfam02254 211110005189 TrkA-C domain; Region: TrkA_C; pfam02080 211110005190 ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619 211110005191 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 211110005192 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 211110005193 Walker A/P-loop; other site 211110005194 ATP binding site [chemical binding]; other site 211110005195 Q-loop/lid; other site 211110005196 ABC transporter signature motif; other site 211110005197 Walker B; other site 211110005198 D-loop; other site 211110005199 H-loop/switch region; other site 211110005200 ATP-binding cassette cobalt transporter; Region: DUF3744; pfam12558 211110005201 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 211110005202 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 211110005203 Walker A/P-loop; other site 211110005204 ATP binding site [chemical binding]; other site 211110005205 Q-loop/lid; other site 211110005206 ABC transporter signature motif; other site 211110005207 Walker B; other site 211110005208 D-loop; other site 211110005209 H-loop/switch region; other site 211110005210 hypothetical protein; Provisional; Region: PRK13661 211110005211 serine/threonine transporter SstT; Provisional; Region: PRK13628 211110005212 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 211110005213 Branched-chain amino acid transport protein; Region: Branch_AA_trans; pfam05525 211110005214 formaldehyde dehydrogenase (FDH)-like; Region: FDH_like_ADH2; cd08286 211110005215 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 211110005216 catalytic Zn binding site [ion binding]; other site 211110005217 structural Zn binding site [ion binding]; other site 211110005218 NAD(P) binding site [chemical binding]; other site 211110005219 ABC-type metal ion transport system, permease component [Inorganic ion transport and metabolism]; Region: AbcD; COG2011 211110005220 ABC-type metal ion transport system, ATPase component [Inorganic ion transport and metabolism]; Region: AbcC; COG1135 211110005221 ATP-binding cassette domain of methionine transporter; Region: ABC_MetN_methionine_transporter; cd03258 211110005222 Walker A/P-loop; other site 211110005223 ATP binding site [chemical binding]; other site 211110005224 Q-loop/lid; other site 211110005225 ABC transporter signature motif; other site 211110005226 Walker B; other site 211110005227 D-loop; other site 211110005228 H-loop/switch region; other site 211110005229 NIL domain; Region: NIL; pfam09383 211110005230 hypothetical protein; Provisional; Region: PRK06446 211110005231 Uncharacterized M20 Dipeptidases; Region: M20_dipept_like_4; cd05681 211110005232 metal binding site [ion binding]; metal-binding site 211110005233 dimer interface [polypeptide binding]; other site 211110005234 NLPA lipoprotein; Region: Lipoprotein_9; pfam03180 211110005235 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 211110005236 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 211110005237 substrate binding pocket [chemical binding]; other site 211110005238 membrane-bound complex binding site; other site 211110005239 hinge residues; other site 211110005240 Peptidase C26; Region: Peptidase_C26; pfam07722 211110005241 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_2; cd01745 211110005242 catalytic triad [active] 211110005243 hypothetical protein; Provisional; Region: PRK12378 211110005244 Dihydroxyacetone kinase [Carbohydrate transport and metabolism]; Region: DAK1; COG2376 211110005245 probable dihydroxyacetone kinase DhaK1b subunit; Region: dhaK1b; TIGR02362 211110005246 probable dihydroxyacetone kinase regulator; Region: DHAK_reg; TIGR02366 211110005247 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 211110005248 dihydroxyacetone kinase subunit DhaK; Provisional; Region: PRK14481 211110005249 Dihydroxyacetone kinase [Carbohydrate transport and metabolism]; Region: DAK1; COG2376 211110005250 dihydroxyacetone kinase, phosphoprotein-dependent, L subunit; Region: dha_L_ycgS; TIGR02365 211110005251 phosphotransferase mannnose-specific family component IIA; Provisional; Region: PRK14484 211110005252 Glycerol uptake facilitator and related permeases (Major Intrinsic Protein Family) [Carbohydrate transport and metabolism]; Region: GlpF; COG0580 211110005253 amphipathic channel; other site 211110005254 Asn-Pro-Ala signature motifs; other site 211110005255 Mannose-6-phosphate isomerase [Carbohydrate transport and metabolism]; Region: {ManC}; COG0662 211110005256 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 211110005257 Helix-Turn-Helix DNA binding domain of the transcription regulators TipAL, Mta, and SkgA; Region: HTH_TipAL-Mta; cd01106 211110005258 DNA binding residues [nucleotide binding] 211110005259 dimer interface [polypeptide binding]; other site 211110005260 TipAS antibiotic-recognition domain; Region: TipAS; pfam07739 211110005261 HIGH Nucleotidyl Transferase; Region: HIGH_NTase1; pfam05636 211110005262 hypothetical protein; Provisional; Region: PRK13670 211110005263 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 211110005264 S-adenosylmethionine binding site [chemical binding]; other site 211110005265 Uncharacterized homolog of plant Iojap protein [Function unknown]; Region: COG0799 211110005266 Nicotinamidase_ related amidohydrolases. Cysteine hydrolases of unknown function that share the catalytic triad with other amidohydrolases, like nicotinamidase, which converts nicotinamide to nicotinic acid and ammonia; Region: nicotinamidase_related; cd01014 211110005267 catalytic triad [active] 211110005268 conserved cis-peptide bond; other site 211110005269 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 211110005270 Zn2+ binding site [ion binding]; other site 211110005271 Mg2+ binding site [ion binding]; other site 211110005272 nicotinic acid mononucleotide adenylyltransferase; Provisional; Region: nadD; PRK00071 211110005273 Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165 211110005274 active site 211110005275 (T/H)XGH motif; other site 211110005276 Predicted RNA-binding protein containing KH domain, possibly ribosomal protein [Translation, ribosomal structure and biogenesis]; Region: COG1534 211110005277 GTPase YqeH; Provisional; Region: PRK13796 211110005278 Circularly permuted YqeH GTPase; Region: YqeH; cd01855 211110005279 GTP/Mg2+ binding site [chemical binding]; other site 211110005280 G4 box; other site 211110005281 G5 box; other site 211110005282 G1 box; other site 211110005283 Switch I region; other site 211110005284 G2 box; other site 211110005285 G3 box; other site 211110005286 Switch II region; other site 211110005287 Predicted hydrolase of the HAD superfamily [General function prediction only]; Region: COG2179 211110005288 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 211110005289 active site 211110005290 motif I; other site 211110005291 motif II; other site 211110005292 EamA-like transporter family; Region: EamA; pfam00892 211110005293 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 211110005294 EamA-like transporter family; Region: EamA; pfam00892 211110005295 aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477 211110005296 GatB/GatE catalytic domain; Region: GatB_N; pfam02934 211110005297 GatB domain; Region: GatB_Yqey; pfam02637 211110005298 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 211110005299 aspartyl/glutamyl-tRNA amidotransferase subunit A; Reviewed; Region: gatA; PRK00012 211110005300 aspartyl/glutamyl-tRNA amidotransferase subunit C; Reviewed; Region: gatC; PRK00034 211110005301 pyruvate phosphate dikinase; Provisional; Region: PRK09279 211110005302 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 211110005303 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 211110005304 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 211110005305 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 211110005306 PEP synthetase regulatory protein; Provisional; Region: PRK05339 211110005307 HTH domain; Region: HTH_11; pfam08279 211110005308 FOG: CBS domain [General function prediction only]; Region: COG0517 211110005309 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_4; cd04617 211110005310 3-hydroxybutyryl-CoA dehydrogenase; Validated; Region: PRK08293 211110005311 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 211110005312 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 211110005313 Isochorismatase family; Region: Isochorismatase; pfam00857 211110005314 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 211110005315 catalytic triad [active] 211110005316 conserved cis-peptide bond; other site 211110005317 transcriptional repressor CodY; Validated; Region: PRK04158 211110005318 CodY GAF-like domain; Region: CodY; pfam06018 211110005319 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 211110005320 dimerization interface [polypeptide binding]; other site 211110005321 putative Zn2+ binding site [ion binding]; other site 211110005322 putative DNA binding site [nucleotide binding]; other site 211110005323 aminotransferase AlaT; Validated; Region: PRK09265 211110005324 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 211110005325 pyridoxal 5'-phosphate binding site [chemical binding]; other site 211110005326 homodimer interface [polypeptide binding]; other site 211110005327 catalytic residue [active] 211110005328 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 211110005329 Ligand Binding Site [chemical binding]; other site 211110005330 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 211110005331 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 211110005332 active site 211110005333 motif I; other site 211110005334 motif II; other site 211110005335 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 211110005336 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4696 211110005337 metal binding site [ion binding]; metal-binding site 211110005338 Type II (periplasmic) bacterial L-asparaginase; Region: L-asparaginase_II; cd08964 211110005339 active site 211110005340 homotetramer interface [polypeptide binding]; other site 211110005341 homodimer interface [polypeptide binding]; other site 211110005342 Shikimate 5-dehydrogenase [Amino acid transport and metabolism]; Region: AroE; COG0169 211110005343 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 211110005344 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 211110005345 shikimate binding site; other site 211110005346 NAD(P) binding site [chemical binding]; other site 211110005347 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 211110005348 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 211110005349 active site 211110005350 catalytic tetrad [active] 211110005351 ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917 211110005352 RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488 211110005353 generic binding surface II; other site 211110005354 ssDNA binding site; other site 211110005355 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 211110005356 ATP binding site [chemical binding]; other site 211110005357 putative Mg++ binding site [ion binding]; other site 211110005358 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 211110005359 nucleotide binding region [chemical binding]; other site 211110005360 ATP-binding site [chemical binding]; other site 211110005361 Surface antigen [General function prediction only]; Region: COG3942 211110005362 CHAP domain; Region: CHAP; pfam05257 211110005363 alanine racemase; Reviewed; Region: alr; PRK00053 211110005364 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430 211110005365 active site 211110005366 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 211110005367 dimer interface [polypeptide binding]; other site 211110005368 substrate binding site [chemical binding]; other site 211110005369 catalytic residues [active] 211110005370 4'-phosphopantetheinyl transferase; Provisional; Region: acpS; PRK00070 211110005371 phospho-2-dehydro-3-deoxyheptonate aldolase; Validated; Region: PRK09261 211110005372 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 211110005373 preprotein translocase subunit SecA; Reviewed; Region: PRK12904 211110005374 SecA preprotein cross-linking domain; Region: SecA_PP_bind; pfam01043 211110005375 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 211110005376 nucleotide binding region [chemical binding]; other site 211110005377 ATP-binding site [chemical binding]; other site 211110005378 SEC-C motif; Region: SEC-C; pfam02810 211110005379 Phosphomannose isomerase [Carbohydrate transport and metabolism]; Region: ManA; COG1482 211110005380 mannose-6-phosphate isomerase, class I; Region: manA; TIGR00218 211110005381 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 211110005382 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 211110005383 nucleotide binding site [chemical binding]; other site 211110005384 PTS system, sucrose-specific IIBC component; Region: PTS-II-BC-sucr; TIGR01996 211110005385 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 211110005386 active site turn [active] 211110005387 phosphorylation site [posttranslational modification] 211110005388 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 211110005389 PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_glc; cd00210 211110005390 HPr interaction site; other site 211110005391 glycerol kinase (GK) interaction site [polypeptide binding]; other site 211110005392 active site 211110005393 phosphorylation site [posttranslational modification] 211110005394 sucrose-6-phosphate hydrolase; Region: scrB_fam; TIGR01322 211110005395 Glycosyl hydrolase family 32, beta-fructosidases; Region: GH32_B_Fructosidase; cd08996 211110005396 substrate binding [chemical binding]; other site 211110005397 active site 211110005398 Glycosyl hydrolases family 32 C terminal; Region: Glyco_hydro_32C; pfam08244 211110005399 Transcriptional regulators [Transcription]; Region: PurR; COG1609 211110005400 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 211110005401 DNA binding site [nucleotide binding] 211110005402 domain linker motif; other site 211110005403 Ligand binding domain of the lacI-like transcription regulator from a novel metal-reducing bacterium Alkaliphilus Metalliredigens (strain Qymf) and its close homologs; Region: PBP1_Qymf_like; cd06291 211110005404 dimerization interface [polypeptide binding]; other site 211110005405 ligand binding site [chemical binding]; other site 211110005406 sodium binding site [ion binding]; other site 211110005407 transcription antitermination protein NusB; Reviewed; Region: nusB; PRK00202 211110005408 putative RNA binding site [nucleotide binding]; other site 211110005409 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1302 211110005410 elongation factor P; Validated; Region: PRK00529 211110005411 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 211110005412 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 211110005413 RNA binding site [nucleotide binding]; other site 211110005414 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 211110005415 RNA binding site [nucleotide binding]; other site 211110005416 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 211110005417 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 211110005418 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 211110005419 Walker A/P-loop; other site 211110005420 ATP binding site [chemical binding]; other site 211110005421 Q-loop/lid; other site 211110005422 ABC transporter signature motif; other site 211110005423 Walker B; other site 211110005424 D-loop; other site 211110005425 H-loop/switch region; other site 211110005426 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 211110005427 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 211110005428 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 211110005429 Walker A/P-loop; other site 211110005430 ATP binding site [chemical binding]; other site 211110005431 Q-loop/lid; other site 211110005432 ABC transporter signature motif; other site 211110005433 Walker B; other site 211110005434 D-loop; other site 211110005435 H-loop/switch region; other site 211110005436 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 211110005437 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 211110005438 Walker A/P-loop; other site 211110005439 ATP binding site [chemical binding]; other site 211110005440 Q-loop/lid; other site 211110005441 ABC transporter signature motif; other site 211110005442 Walker B; other site 211110005443 D-loop; other site 211110005444 H-loop/switch region; other site 211110005445 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 211110005446 cobalt transport protein ATP-binding subunit; Region: cbiO; TIGR01166 211110005447 Walker A/P-loop; other site 211110005448 ATP binding site [chemical binding]; other site 211110005449 Q-loop/lid; other site 211110005450 ABC transporter signature motif; other site 211110005451 Walker B; other site 211110005452 D-loop; other site 211110005453 H-loop/switch region; other site 211110005454 ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619 211110005455 Hypothetical bacterial integral membrane protein (Trep_Strep); Region: Trep_Strep; pfam09605 211110005456 Similar to 2,3-dihydroxybenzoate-AMP ligase (C-terminal domain);Unknown 211110005457 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 211110005458 acyl-activating enzyme (AAE) consensus motif; other site 211110005459 Mn-dependent transcriptional regulator [Transcription]; Region: TroR; COG1321 211110005460 Iron dependent repressor, metal binding and dimerisation domain; Region: Fe_dep_repr_C; pfam02742 211110005461 Deoxycytidylate deaminase domain. Deoxycytidylate deaminase catalyzes the deamination of dCMP to dUMP, providing the nucleotide substrate for thymidylate synthase. The enzyme binds Zn++, which is required for catalytic activity. The activity of the...; Region: deoxycytidylate_deaminase; cd01286 211110005462 catalytic motif [active] 211110005463 Zn binding site [ion binding]; other site 211110005464 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 211110005465 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 211110005466 Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092 211110005467 active site 211110005468 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 211110005469 Major Facilitator Superfamily; Region: MFS_1; pfam07690 211110005470 putative substrate translocation pore; other site 211110005471 excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349 211110005472 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 211110005473 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 211110005474 ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271 211110005475 Protein of unknown function (DUF1129); Region: DUF1129; cl11555 211110005476 Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598 211110005477 uncharacterized bacterial subfamily of the Escherichia coli CorA-Salmonella typhimurium ZntB family; Region: EcCorA_ZntB-like_u2; cd12827 211110005478 Cl binding site [ion binding]; other site 211110005479 oligomer interface [polypeptide binding]; other site 211110005480 30S ribosomal protein S18; Reviewed; Region: rpsR; PRK00391 211110005481 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 211110005482 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 211110005483 dimer interface [polypeptide binding]; other site 211110005484 ssDNA binding site [nucleotide binding]; other site 211110005485 tetramer (dimer of dimers) interface [polypeptide binding]; other site 211110005486 30S ribosomal protein S6; Reviewed; Region: rpsF; PRK00453 211110005487 A/G-specific DNA glycosylase [DNA replication, recombination, and repair]; Region: MutY; COG1194 211110005488 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 211110005489 minor groove reading motif; other site 211110005490 helix-hairpin-helix signature motif; other site 211110005491 substrate binding pocket [chemical binding]; other site 211110005492 active site 211110005493 DNA glycosylase (MutY in bacteria and hMYH in humans) is responsible for repairing misread A*oxoG residues to C*G by removing the inappropriately paired adenine base from the DNA backbone. It belongs to the Nudix hydrolase superfamily and is important...; Region: DNA_Glycosylase_C; cd03431 211110005494 DNA binding and oxoG recognition site [nucleotide binding] 211110005495 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 211110005496 non-specific DNA binding site [nucleotide binding]; other site 211110005497 salt bridge; other site 211110005498 sequence-specific DNA binding site [nucleotide binding]; other site 211110005499 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 211110005500 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 211110005501 catalytic residues [active] 211110005502 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 211110005503 PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cd01610 211110005504 active site 211110005505 Mismatch repair ATPase (MutS family) [DNA replication, recombination, and repair]; Region: COG1193 211110005506 MutS domain III; Region: MutS_III; pfam05192 211110005507 ATP-binding cassette domain of MutS2; Region: ABC_MutS2; cd03280 211110005508 Walker A/P-loop; other site 211110005509 ATP binding site [chemical binding]; other site 211110005510 Q-loop/lid; other site 211110005511 ABC transporter signature motif; other site 211110005512 Walker B; other site 211110005513 D-loop; other site 211110005514 H-loop/switch region; other site 211110005515 Smr domain; Region: Smr; pfam01713 211110005516 Uncharacterized membrane protein, required for colicin V production [General function prediction only]; Region: CvpA; COG1286 211110005517 Colicin V production protein; Region: Colicin_V; pfam02674 211110005518 ribonuclease HIII; Provisional; Region: PRK00996 211110005519 Domain of unknown function (DUF3378); Region: DUF3378; pfam11858 211110005520 bacterial Ribonuclease HIII-like; Region: RNase_HII_bacteria_HIII_like; cd06590 211110005521 RNA/DNA hybrid binding site [nucleotide binding]; other site 211110005522 active site 211110005523 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 211110005524 The S24, S26 LexA/signal peptidase superfamily contains LexA-related and type I signal peptidase families. The S24 LexA protein domains include: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC 3.4.21.88), the...; Region: Peptidase_S24_S26; cd06462 211110005525 Catalytic site [active] 211110005526 helicase, putative, RecD/TraA family; Region: recD_rel; TIGR01448 211110005527 AAA domain; Region: AAA_30; pfam13604 211110005528 Family description; Region: UvrD_C_2; pfam13538 211110005529 DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586 211110005530 active site 211110005531 DNA polymerase IV; Validated; Region: PRK02406 211110005532 DNA binding site [nucleotide binding] 211110005533 formate acetyltransferase 1; Region: pyr_form_ly_1; TIGR01255 211110005534 Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939 211110005535 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243 211110005536 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 211110005537 Beta-lactamase; Region: Beta-lactamase; pfam00144 211110005538 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 211110005539 active site 211110005540 metal binding site [ion binding]; metal-binding site 211110005541 Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cd00333 211110005542 amphipathic channel; other site 211110005543 Asn-Pro-Ala signature motifs; other site 211110005544 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 211110005545 Ligand Binding Site [chemical binding]; other site 211110005546 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 211110005547 Major Facilitator Superfamily; Region: MFS_1; pfam07690 211110005548 putative substrate translocation pore; other site 211110005549 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 211110005550 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cl17320 211110005551 x-prolyl-dipeptidyl aminopeptidase; Provisional; Region: PRK05371 211110005552 X-Prolyl dipeptidyl aminopeptidase PepX, N-terminal; Region: PepX_N; pfam09168 211110005553 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 211110005554 X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain; Region: PepX_C; pfam08530 211110005555 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 211110005556 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 211110005557 substrate binding pocket [chemical binding]; other site 211110005558 chain length determination region; other site 211110005559 substrate-Mg2+ binding site; other site 211110005560 catalytic residues [active] 211110005561 aspartate-rich region 1; other site 211110005562 active site lid residues [active] 211110005563 aspartate-rich region 2; other site 211110005564 ABC-type transport system involved in cytochrome bd biosynthesis, fused ATPase and permease components [Energy production and conversion / Posttranslational modification, protein turnover, chaperones]; Region: CydC; COG4987 211110005565 ATP-binding cassette domain of CydCD, subfamily C; Region: ABCC_cytochrome_bd; cd03247 211110005566 Walker A/P-loop; other site 211110005567 ATP binding site [chemical binding]; other site 211110005568 Q-loop/lid; other site 211110005569 ABC transporter signature motif; other site 211110005570 Walker B; other site 211110005571 D-loop; other site 211110005572 H-loop/switch region; other site 211110005573 ABC-type transport system involved in cytochrome bd biosynthesis, ATPase and permease components [Energy production and conversion / Posttranslational modification, protein turnover, chaperones]; Region: CydD; COG4988 211110005574 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 211110005575 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 211110005576 Walker A/P-loop; other site 211110005577 ATP binding site [chemical binding]; other site 211110005578 Q-loop/lid; other site 211110005579 ABC transporter signature motif; other site 211110005580 Walker B; other site 211110005581 D-loop; other site 211110005582 H-loop/switch region; other site 211110005583 Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322 211110005584 cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219 211110005585 cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219 211110005586 Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; pfam01654 211110005587 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 211110005588 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 211110005589 1,4-dihydroxy-2-naphthoate octaprenyltransferase; Validated; Region: PRK06080 211110005590 UbiA prenyltransferase family; Region: UbiA; pfam01040 211110005591 hypothetical protein; Validated; Region: PRK00153 211110005592 Cyclopropane fatty acid synthase and related methyltransferases [Cell envelope biogenesis, outer membrane]; Region: Cfa; COG2230 211110005593 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 211110005594 S-adenosylmethionine binding site [chemical binding]; other site 211110005595 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 211110005596 Helix-Turn-Helix DNA binding domain of the transcription regulators TipAL, Mta, and SkgA; Region: HTH_TipAL-Mta; cd01106 211110005597 DNA binding residues [nucleotide binding] 211110005598 dimer interface [polypeptide binding]; other site 211110005599 DNA polymerase III, epsilon subunit and related 3'-5' exonucleases [DNA replication, recombination, and repair]; Region: DnaQ; COG0847 211110005600 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 211110005601 active site 211110005602 catalytic site [active] 211110005603 substrate binding site [chemical binding]; other site 211110005604 HI0933-like protein; Region: HI0933_like; pfam03486 211110005605 hydroxyglutarate oxidase; Provisional; Region: PRK11728 211110005606 HIT family: HIT (Histidine triad) proteins, named for a motif related to the sequence HxHxH/Qxx (x, a hydrophobic amino acid), are a superfamily of nucleotide hydrolases and transferases, which act on the alpha-phosphate of ribonucleotides. On the basis...; Region: HIT_like; cl00228 211110005607 nucleotide binding site/active site [active] 211110005608 HIT family signature motif; other site 211110005609 catalytic residue [active] 211110005610 30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08881 211110005611 Threonine aldolase [Amino acid transport and metabolism]; Region: GLY1; COG2008 211110005612 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 211110005613 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 211110005614 catalytic residue [active] 211110005615 UGMP family protein; Validated; Region: PRK09604 211110005616 Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214; cl17884 211110005617 Carbamoyltransferase; Region: CmcH_NodU; pfam02543 211110005618 ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575 211110005619 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 211110005620 Coenzyme A binding pocket [chemical binding]; other site 211110005621 tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725 211110005622 Glycoprotease family; Region: Peptidase_M22; pfam00814 211110005623 hypothetical protein; Provisional; Region: PRK13667 211110005624 mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595 211110005625 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 211110005626 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 211110005627 CHAP domain; Region: CHAP; cl17642 211110005628 Surface antigen [General function prediction only]; Region: COG3942 211110005629 Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174 211110005630 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 211110005631 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 211110005632 Helix-Turn-Helix DNA binding domain of GlnR-like transcription regulators; Region: HTH_GlnR-like; cd01105 211110005633 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 211110005634 DNA binding residues [nucleotide binding] 211110005635 putative dimer interface [polypeptide binding]; other site 211110005636 Predicted membrane protein [Function unknown]; Region: COG4129 211110005637 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 211110005638 phosphoglycerate kinase; Provisional; Region: pgk; PRK00073 211110005639 Phosphoglycerate kinase; Region: PGK; pfam00162 211110005640 substrate binding site [chemical binding]; other site 211110005641 hinge regions; other site 211110005642 ADP binding site [chemical binding]; other site 211110005643 catalytic site [active] 211110005644 HAD superfamily, subfamily IIIB (Acid phosphatase); Region: Acid_phosphat_B; cl17236 211110005645 Glyceraldehyde-3-phosphate dehydrogenase/erythrose-4-phosphate dehydrogenase [Carbohydrate transport and metabolism]; Region: GapA; COG0057 211110005646 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846 211110005647 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 211110005648 elongation factor G; Reviewed; Region: PRK00007 211110005649 Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886 211110005650 G1 box; other site 211110005651 putative GEF interaction site [polypeptide binding]; other site 211110005652 GTP/Mg2+ binding site [chemical binding]; other site 211110005653 Switch I region; other site 211110005654 G2 box; other site 211110005655 G3 box; other site 211110005656 Switch II region; other site 211110005657 G4 box; other site 211110005658 G5 box; other site 211110005659 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 211110005660 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 211110005661 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 211110005662 30S ribosomal protein S7; Validated; Region: PRK05302 211110005663 S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368 211110005664 S17 interaction site [polypeptide binding]; other site 211110005665 S8 interaction site; other site 211110005666 16S rRNA interaction site [nucleotide binding]; other site 211110005667 streptomycin interaction site [chemical binding]; other site 211110005668 23S rRNA interaction site [nucleotide binding]; other site 211110005669 aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site 211110005670 pur operon repressor; Provisional; Region: PRK09213 211110005671 Bacterial purine repressor, N-terminal; Region: PuR_N; pfam09182 211110005672 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 211110005673 active site 211110005674 Predicted HD-superfamily hydrolase [General function prediction only]; Region: COG3481 211110005675 YhaM_OBF_like: A subfamily of OB folds similar to that found in Bacillus subtilis YhaM and Staphylococcus aureus cmp-binding factor-1 (SaCBF1). Both these proteins are 3'-to-5'exoribonucleases. YhaM requires Mn2+ or Co2+ for activity and is...; Region: YhaM_OBF_like; cd04492 211110005676 generic binding surface II; other site 211110005677 generic binding surface I; other site 211110005678 integrating conjugative element relaxase, PFL_4751 family; Region: ICE_TraI_Pfluor; TIGR03760 211110005679 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 211110005680 Zn2+ binding site [ion binding]; other site 211110005681 Mg2+ binding site [ion binding]; other site 211110005682 Predicted nuclease of restriction endonuclease-like fold, RmuC family [General function prediction only]; Region: COG1322 211110005683 RmuC family; Region: RmuC; pfam02646 211110005684 Thiamine pyrophosphokinase; Region: TPK; cd07995 211110005685 thiamine pyrophosphokinase; Region: thi_PPkinase; TIGR01378 211110005686 active site 211110005687 dimerization interface [polypeptide binding]; other site 211110005688 thiamine binding site [chemical binding]; other site 211110005689 Pentose-5-phosphate-3-epimerase [Carbohydrate transport and metabolism]; Region: Rpe; COG0036 211110005690 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 211110005691 substrate binding site [chemical binding]; other site 211110005692 hexamer interface [polypeptide binding]; other site 211110005693 metal binding site [ion binding]; metal-binding site 211110005694 GTPase RsgA; Reviewed; Region: PRK00098 211110005695 S1_YloQ_GTPase: YloQ GTase family (also known as YjeQ and CpgA), S1-like RNA-binding domain. Proteins in the YloQ GTase family bind the ribosome and have GTPase activity. The precise role of this family is unknown. The protein structure is composed of...; Region: S1_YloQ_GTPase; cd04466 211110005696 RNA binding site [nucleotide binding]; other site 211110005697 homodimer interface [polypeptide binding]; other site 211110005698 Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854 211110005699 GTPase/Zn-binding domain interface [polypeptide binding]; other site 211110005700 GTP/Mg2+ binding site [chemical binding]; other site 211110005701 G4 box; other site 211110005702 G1 box; other site 211110005703 Switch I region; other site 211110005704 G2 box; other site 211110005705 G3 box; other site 211110005706 Switch II region; other site 211110005707 Methyltransferase domain; Region: Methyltransf_31; pfam13847 211110005708 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 211110005709 S-adenosylmethionine binding site [chemical binding]; other site 211110005710 16S ribosomal RNA methyltransferase KsgA/Dim1 family protein; Reviewed; Region: ksgA; PRK00274 211110005711 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 211110005712 S-adenosylmethionine binding site [chemical binding]; other site 211110005713 Diadenosine tetraphosphate (Ap4A) hydrolase and other HIT family hydrolases [Nucleotide transport and metabolism / Carbohydrate transport and metabolism / General function prediction only]; Region: Hit; COG0537 211110005714 nucleotide binding site/active site [active] 211110005715 HIT family signature motif; other site 211110005716 catalytic residue [active] 211110005717 ribonuclease M5; Region: 5S_RNA_mat_M5; TIGR00334 211110005718 TOPRIM_ RNase M5_like: The topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain found in Ribonuclease M5: (RNase M5) and other small primase-like proteins from bacteria and archaea. RNase M5 catalyzes the maturation of 5S rRNA in low...; Region: TOPRIM_RNase_M5_like; cd01027 211110005719 putative active site [active] 211110005720 putative metal binding site [ion binding]; other site 211110005721 Domain of unknown function (DUF4093); Region: DUF4093; pfam13331 211110005722 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 211110005723 Predicted metal-dependent hydrolases with the TIM-barrel fold [General function prediction only]; Region: COG1099 211110005724 active site 211110005725 triacylglycerol lipase; Region: PLN00413 211110005726 Protein of unknown function (DUF1310); Region: DUF1310; pfam07006 211110005727 DltD N-terminal region; Region: DltD_N; pfam04915 211110005728 D-alanyl-lipoteichoic acid biosynthesis protein DltD; Region: LTA_DltD; TIGR04092 211110005729 DltD central region; Region: DltD_M; pfam04918 211110005730 DltD C-terminal region; Region: DltD_C; pfam04914 211110005731 D-alanine--poly(phosphoribitol) ligase subunit 2; Validated; Region: PRK05087 211110005732 D-alanyl-lipoteichoic acid biosynthesis protein DltB; Region: LTA_dltB; TIGR04091 211110005733 D-alanine--poly(phosphoribitol) ligase subunit 1; Provisional; Region: PRK04813 211110005734 D-alanine:D-alanyl carrier protein ligase (DltA); Region: DltA; cd05945 211110005735 acyl-activating enzyme (AAE) consensus motif; other site 211110005736 AMP binding site [chemical binding]; other site 211110005737 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 211110005738 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 211110005739 dimer interface [polypeptide binding]; other site 211110005740 phosphorylation site [posttranslational modification] 211110005741 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 211110005742 ATP binding site [chemical binding]; other site 211110005743 Mg2+ binding site [ion binding]; other site 211110005744 G-X-G motif; other site 211110005745 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 211110005746 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 211110005747 active site 211110005748 phosphorylation site [posttranslational modification] 211110005749 intermolecular recognition site; other site 211110005750 dimerization interface [polypeptide binding]; other site 211110005751 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 211110005752 DNA binding site [nucleotide binding] 211110005753 50S ribosomal protein L34; Reviewed; Region: rpmH; PRK00399 211110005754 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3314 211110005755 Nucleoside recognition; Region: Gate; pfam07670 211110005756 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 211110005757 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 211110005758 dimer interface [polypeptide binding]; other site 211110005759 conserved gate region; other site 211110005760 putative PBP binding loops; other site 211110005761 ABC-ATPase subunit interface; other site 211110005762 ABC-type proline/glycine betaine transport systems, periplasmic components [Amino acid transport and metabolism]; Region: ProX; COG2113 211110005763 Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069 211110005764 ABC-type proline/glycine betaine transport system, ATPase component [Amino acid transport and metabolism]; Region: ProV; COG4175 211110005765 ATP-binding cassette domain of the osmoprotectant proline/glycine betaine uptake system; Region: ABC_Pro_Gly_Betaine; cd03294 211110005766 Walker A/P-loop; other site 211110005767 ATP binding site [chemical binding]; other site 211110005768 Q-loop/lid; other site 211110005769 ABC transporter signature motif; other site 211110005770 Walker B; other site 211110005771 D-loop; other site 211110005772 H-loop/switch region; other site 211110005773 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 211110005774 XFP N-terminal domain; Region: XFP_N; pfam09364 211110005775 putative phosphoketolase; Provisional; Region: PRK05261 211110005776 XFP C-terminal domain; Region: XFP_C; pfam09363 211110005777 putative L-ascorbate 6-phosphate lactonase; Provisional; Region: PRK11709 211110005778 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 211110005779 Transcriptional antiterminator [Transcription]; Region: BglG; COG3711 211110005780 PRD domain; Region: PRD; pfam00874 211110005781 PRD domain; Region: PRD; pfam00874 211110005782 PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568 211110005783 active site 211110005784 P-loop; other site 211110005785 phosphorylation site [posttranslational modification] 211110005786 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 211110005787 Sugar (pentulose and hexulose) kinases [Carbohydrate transport and metabolism]; Region: XylB; COG1070 211110005788 L-xylulose kinases; a subfamily of the FGGY family of carbohydrate kinases; Region: FGGY_L-XK; cd07802 211110005789 putative N- and C-terminal domain interface [polypeptide binding]; other site 211110005790 putative active site [active] 211110005791 MgATP binding site [chemical binding]; other site 211110005792 catalytic site [active] 211110005793 metal binding site [ion binding]; metal-binding site 211110005794 putative xylulose binding site [chemical binding]; other site 211110005795 Predicted metal-dependent hydrolase of the TIM-barrel fold [General function prediction only]; Region: COG3618 211110005796 Amidohydrolase; Region: Amidohydro_2; pfam04909 211110005797 Phosphotransferase system, galactitol-specific IIC component [Carbohydrate transport and metabolism]; Region: GatC; COG3775 211110005798 PTS system sugar-specific permease component; Region: EIIC-GAT; pfam03611 211110005799 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052 211110005800 Putative D-isomer specific 2-hydroxyacid dehydrogenases, NAD-binding and catalytic domains; Region: 2-Hacid_dh_13; cd12178 211110005801 putative ligand binding site [chemical binding]; other site 211110005802 putative NAD binding site [chemical binding]; other site 211110005803 catalytic site [active] 211110005804 Transcriptional regulators [Transcription]; Region: PurR; COG1609 211110005805 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 211110005806 DNA binding site [nucleotide binding] 211110005807 domain linker motif; other site 211110005808 Ligand-binding domain of DNA transcription repressor RegR and other putative regulators such as KdgR and EndR; Region: PBP1_RegR_EndR_KdgR_like; cd06283 211110005809 putative dimerization interface [polypeptide binding]; other site 211110005810 putative ligand binding site [chemical binding]; other site 211110005811 Transaldolase-like fructose-6-phosphate aldolases (FSA) found in bacteria and archaea; Region: Transaldolase_FSA; cd00956 211110005812 active site 211110005813 intersubunit interactions; other site 211110005814 catalytic residue [active] 211110005815 L-ribulose-5-phosphate 4-epimerase; Provisional; Region: araD; PRK13145 211110005816 L-ribulose-5-phosphate 4-epimerase; Reviewed; Region: araD; PRK08193 211110005817 intersubunit interface [polypeptide binding]; other site 211110005818 active site 211110005819 Zn2+ binding site [ion binding]; other site 211110005820 putative L-xylulose 5-phosphate 3-epimerase; Reviewed; Region: PRK13210 211110005821 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cd00019 211110005822 AP (apurinic/apyrimidinic) site pocket; other site 211110005823 DNA interaction; other site 211110005824 Metal-binding active site; metal-binding site 211110005825 3-Keto-L-gulonate 6-phosphate decarboxylase (KGPDC) and D-arabino-3-hexulose-6-phosphate synthase (HPS). KGPDC catalyzes the formation of L-xylulose 5-phosphate and carbon dioxide from 3-keto-L-gulonate 6-phosphate as part of the anaerobic pathway for...; Region: KGPDC_HPS; cd04726 211110005826 active site 211110005827 dimer interface [polypeptide binding]; other site 211110005828 magnesium binding site [ion binding]; other site 211110005829 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 211110005830 active site 211110005831 phosphorylation site [posttranslational modification] 211110005832 PTS_IIB_ascorbate: subunit IIB of enzyme II (EII) of the L-ascorbate-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is an L-ascorbate-specific permease with two cytoplasmic subunits (IIA and IIB) and a...; Region: PTS_IIB_ascorbate; cd05563 211110005833 active site 211110005834 P-loop; other site 211110005835 phosphorylation site [posttranslational modification] 211110005836 PTS system ascorbate-specific transporter subunit IIC; Reviewed; Region: PRK12997 211110005837 L-aminoadipate-semialdehyde dehydrogenase; Region: alpha_am_amid; TIGR03443 211110005838 Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788 211110005839 Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108 211110005840 GDP-binding site [chemical binding]; other site 211110005841 ACT binding site; other site 211110005842 IMP binding site; other site 211110005843 Phosphotransferase system, fructose-specific IIC component [Carbohydrate transport and metabolism]; Region: FruA; cl17425 211110005844 Phosphotransferase system, EIIC; Region: PTS_EIIC_2; pfam13303 211110005845 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2964 211110005846 YheO-like PAS domain; Region: PAS_6; pfam08348 211110005847 HTH domain; Region: HTH_22; pfam13309 211110005848 bifunctional glutamate--cysteine ligase/glutathione synthetase; Provisional; Region: PRK02471 211110005849 Glutamate-cysteine ligase; Region: Glu_cys_ligase; cl17352 211110005850 ATP-grasp domain; Region: ATP-grasp_4; cl17255 211110005851 Positive regulator of sigma(E), RseC/MucC; Region: RseC_MucC; cl01178 211110005852 Uncharacterized protein involved in tellurite resistance [Inorganic ion transport and metabolism]; Region: TelA; COG3853 211110005853 Hsp33-like chaperonin; Reviewed; Region: hslO; PRK00114 211110005854 Heat shock protein 33 (Hsp33): Cytosolic protein that acts as a molecular chaperone under oxidative conditions. In normal (reducing) cytosolic conditions, four conserved Cys residues are coordinated by a Zn ion. Under oxidative stress (such as heat...; Region: Hsp33; cd00498 211110005855 dimerization interface [polypeptide binding]; other site 211110005856 domain crossover interface; other site 211110005857 redox-dependent activation switch; other site 211110005858 putative TIM-barrel protein, nifR3 family; Region: nifR3_yhdG; TIGR00737 211110005859 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 211110005860 FMN binding site [chemical binding]; other site 211110005861 active site 211110005862 catalytic residues [active] 211110005863 substrate binding site [chemical binding]; other site 211110005864 Deoxynucleoside kinases [Nucleotide transport and metabolism]; Region: COG1428 211110005865 Deoxyribonucleoside kinase (dNK) catalyzes the phosphorylation of deoxyribonucleosides to yield corresponding monophosphates (dNMPs). This family consists of various deoxynucleoside kinases including deoxyribo- cytidine (EC 2.7.1.74), guanosine (EC 2.7.1; Region: dNK; cd01673 211110005866 Substrate-binding site [chemical binding]; other site 211110005867 Substrate specificity [chemical binding]; other site 211110005868 Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247 211110005869 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 211110005870 Coenzyme A binding pocket [chemical binding]; other site 211110005871 ATP-binding subunits of Clp protease and DnaK/DnaJ chaperones [Posttranslational modification, protein turnover, chaperones]; Region: clpA; COG0542 211110005872 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 211110005873 Walker A motif; other site 211110005874 ATP binding site [chemical binding]; other site 211110005875 Walker B motif; other site 211110005876 arginine finger; other site 211110005877 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 211110005878 Walker A motif; other site 211110005879 ATP binding site [chemical binding]; other site 211110005880 Walker B motif; other site 211110005881 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 211110005882 Firmicute transcriptional repressor of class III stress genes (CtsR); Region: CtsR; pfam05848 211110005883 Putative small multi-drug export protein; Region: Sm_multidrug_ex; pfam06695 211110005884 elongation factor Ts; Provisional; Region: tsf; PRK09377 211110005885 UBA/TS-N domain; Region: UBA; pfam00627 211110005886 Elongation factor TS; Region: EF_TS; pfam00889 211110005887 Elongation factor TS; Region: EF_TS; pfam00889 211110005888 Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425 211110005889 rRNA interaction site [nucleotide binding]; other site 211110005890 S8 interaction site; other site 211110005891 putative laminin-1 binding site; other site 211110005892 peroxiredoxin; Region: AhpC; TIGR03137 211110005893 Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015 211110005894 dimer interface [polypeptide binding]; other site 211110005895 decamer (pentamer of dimers) interface [polypeptide binding]; other site 211110005896 catalytic triad [active] 211110005897 peroxidatic and resolving cysteines [active] 211110005898 alkyl hydroperoxide reductase subunit F; Provisional; Region: PRK15317 211110005899 Alkyl hydroperoxide reductase F subunit (AhpF) N-terminal domain (NTD) family, N-terminal TRX-fold subdomain; AhpF is a homodimeric flavoenzyme which catalyzes the NADH-dependent reduction of the peroxiredoxin AhpC, which in turn catalyzes the reduction...; Region: AhpF_NTD_N; cd02974 211110005900 catalytic residue [active] 211110005901 TRX-GRX-like family, Alkyl hydroperoxide reductase F subunit (AhpF) N-terminal domain (NTD) subfamily, C-terminal TRX-fold subdomain; AhpF is a homodimeric flavoenzyme which catalyzes the NADH-dependent reduction of the peroxiredoxin AhpC, which then...; Region: AhpF_NTD_C; cd03026 211110005902 catalytic residues [active] 211110005903 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 211110005904 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 211110005905 NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025 211110005906 Microcin C7 self-immunity protein determines resistance to exogenous microcin C7; Region: Peptidase_S66_mccF_like; cd07062 211110005907 putative dimer interface [polypeptide binding]; other site 211110005908 catalytic triad [active] 211110005909 Predicted metalloendopeptidase [Posttranslational modification, protein turnover, chaperones]; Region: PepO; COG3590 211110005910 Peptidase family M13 includes neprilysin, endothelin-converting enzyme I; Region: M13; cd08662 211110005911 active site 211110005912 Zn binding site [ion binding]; other site 211110005913 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 211110005914 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 211110005915 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 211110005916 Major Facilitator Superfamily; Region: MFS_1; pfam07690 211110005917 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 211110005918 putative substrate translocation pore; other site 211110005919 DNA-binding transcriptional activator YeiL; Provisional; Region: PRK10402 211110005920 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 211110005921 ligand binding site [chemical binding]; other site 211110005922 Crp-like helix-turn-helix domain; Region: HTH_Crp_2; pfam13545 211110005923 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 211110005924 active site 211110005925 catalytic residues [active] 211110005926 metal binding site [ion binding]; metal-binding site 211110005927 Transcriptional regulators [Transcription]; Region: PurR; COG1609 211110005928 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 211110005929 DNA binding site [nucleotide binding] 211110005930 domain linker motif; other site 211110005931 Ligand-binding domain of DNA transcription repressor RegR and other putative regulators such as KdgR and EndR; Region: PBP1_RegR_EndR_KdgR_like; cd06283 211110005932 putative dimerization interface [polypeptide binding]; other site 211110005933 putative ligand binding site [chemical binding]; other site 211110005934 Heparinase II/III-like protein; Region: Hepar_II_III; pfam07940 211110005935 Phosphotransferase system, mannose/fructose/N-acetylgalactosamine-specific component IID [Carbohydrate transport and metabolism]; Region: ManZ; COG3716 211110005936 Phosphotransferase system, mannose/fructose/N-acetylgalactosamine-specific component IIC [Carbohydrate transport and metabolism]; Region: ManY; COG3715 211110005937 PTS_IIB, PTS system, Mannose/sorbose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_man; cd00001 211110005938 active site 211110005939 phosphorylation site [posttranslational modification] 211110005940 Glycosyl Hydrolase Family 88; Region: Glyco_hydro_88; pfam07470 211110005941 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006 211110005942 active pocket/dimerization site; other site 211110005943 active site 211110005944 phosphorylation site [posttranslational modification] 211110005945 gluconate 5-dehydrogenase; Provisional; Region: PRK07097 211110005946 gluconate 5-dehydrogenase (Ga5DH)-like, classical (c) SDRs; Region: Ga5DH-like_SDR_c; cd05347 211110005947 NADP binding site [chemical binding]; other site 211110005948 homodimer interface [polypeptide binding]; other site 211110005949 active site 211110005950 hypothetical protein; Provisional; Region: PRK09273 211110005951 Ribose 5-phosphate isomerase RpiB [Carbohydrate transport and metabolism]; Region: RpiB; COG0698 211110005952 Ribose-5-phosphate isomerase; Region: DUF3666; pfam12408 211110005953 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166 211110005954 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 211110005955 substrate binding site [chemical binding]; other site 211110005956 ATP binding site [chemical binding]; other site 211110005957 2-keto-3-deoxy-6-phosphogluconate aldolase [Carbohydrate transport and metabolism]; Region: Eda; COG0800 211110005958 KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452 211110005959 active site 211110005960 intersubunit interface [polypeptide binding]; other site 211110005961 catalytic residue [active] 211110005962 Transglutaminase-like superfamily; Region: Transglut_core; cl17362 211110005963 Nitroreductase-like family 4. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_4; cd02140 211110005964 dimer interface [polypeptide binding]; other site 211110005965 FMN binding site [chemical binding]; other site 211110005966 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 211110005967 MarR family; Region: MarR; pfam01047 211110005968 MarR family; Region: MarR_2; cl17246 211110005969 DNA polymerase III PolC; Validated; Region: polC; PRK00448 211110005970 DNA polymerase III polC-type N-terminus; Region: DNA_pol3_alph_N; pfam11490 211110005971 polC_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold nucleic acid binding domain of Bacillus subtilis type C replicative DNA polymerase III alpha subunit (polC). Replication in B. subtilis and Staphylococcus aureus requires two...; Region: polC_OBF; cd04484 211110005972 generic binding surface II; other site 211110005973 generic binding surface I; other site 211110005974 Polymerase and Histidinol Phosphatase domain; Region: PHP; cl17102 211110005975 active site 211110005976 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 211110005977 active site 211110005978 catalytic site [active] 211110005979 substrate binding site [chemical binding]; other site 211110005980 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III at PolC gene; Region: PHP_PolIIIA_POLC; cd07435 211110005981 Muramidase (flagellum-specific) [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FlgJ; COG1705 211110005982 prolyl-tRNA synthetase; Provisional; Region: PRK09194 211110005983 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 211110005984 motif 1; other site 211110005985 dimer interface [polypeptide binding]; other site 211110005986 active site 211110005987 motif 2; other site 211110005988 INS is an amino acid-editing domain inserted (INS) into the bacterial class II prolyl-tRNA synthetase (ProRS) however, this CD is not exclusively bacterial. It is also found at the N-terminus of the eukaryotic/archaea-like ProRS's of yeasts and...; Region: ProRS-INS; cd04334 211110005989 putative deacylase active site [active] 211110005990 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 211110005991 active site 211110005992 motif 3; other site 211110005993 ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding; Region: ProRS_anticodon_short; cd00861 211110005994 anticodon binding site; other site 211110005995 RIP metalloprotease RseP; Region: TIGR00054 211110005996 Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020 211110005997 Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020 211110005998 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 211110005999 protein binding site [polypeptide binding]; other site 211110006000 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 211110006001 putative substrate binding region [chemical binding]; other site 211110006002 CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575 211110006003 Cytidylyltransferase family; Region: CTP_transf_1; pfam01148 211110006004 Undecaprenyl pyrophosphate synthase [Lipid metabolism]; Region: UppS; COG0020 211110006005 Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cd00475 211110006006 catalytic residue [active] 211110006007 putative FPP diphosphate binding site; other site 211110006008 putative FPP binding hydrophobic cleft; other site 211110006009 dimer interface [polypeptide binding]; other site 211110006010 putative IPP diphosphate binding site; other site 211110006011 preprotein translocase subunit YajC; Validated; Region: yajC; PRK06531 211110006012 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 211110006013 catalytic residues [active] 211110006014 Malic enzyme [Energy production and conversion]; Region: SfcA; COG0281 211110006015 Malic enzyme, N-terminal domain; Region: malic; pfam00390 211110006016 NAD(P) binding domain of malic enzyme (ME), subgroup 2; Region: NAD_bind_2_malic_enz; cd05311 211110006017 putative NAD(P) binding site [chemical binding]; other site 211110006018 2-hydroxycarboxylate transporter family; Region: 2HCT; pfam03390 211110006019 PAS domain; Region: PAS_9; pfam13426 211110006020 Response regulator of citrate/malate metabolism [Transcription / Signal transduction mechanisms]; Region: CitB; COG4565 211110006021 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 211110006022 active site 211110006023 phosphorylation site [posttranslational modification] 211110006024 intermolecular recognition site; other site 211110006025 dimerization interface [polypeptide binding]; other site 211110006026 UDP-glucose 4-epimerase [Cell envelope biogenesis, outer membrane]; Region: GalE; COG1087 211110006027 UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247 211110006028 NAD binding site [chemical binding]; other site 211110006029 homodimer interface [polypeptide binding]; other site 211110006030 active site 211110006031 substrate binding site [chemical binding]; other site 211110006032 alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403 211110006033 Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333 211110006034 Ca binding site [ion binding]; other site 211110006035 active site 211110006036 catalytic site [active] 211110006037 Domain of unknown function (DUF3459); Region: DUF3459; pfam11941 211110006038 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 211110006039 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 211110006040 Walker A/P-loop; other site 211110006041 ATP binding site [chemical binding]; other site 211110006042 Q-loop/lid; other site 211110006043 ABC transporter signature motif; other site 211110006044 Walker B; other site 211110006045 D-loop; other site 211110006046 H-loop/switch region; other site 211110006047 TOBE domain; Region: TOBE_2; pfam08402 211110006048 Regulator of polyketide synthase expression [Signal transduction mechanisms / Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2508 211110006049 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 211110006050 Aldose 1-epimerase, similar to Lactococcus lactis lacX; Region: Aldose_epim_lacX; cd09024 211110006051 active site 211110006052 catalytic residues [active] 211110006053 tagatose 1,6-diphosphate aldolase; Reviewed; Region: PRK12399 211110006054 1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164 211110006055 tagatose-6-phosphate kinase; Region: lacC; TIGR01231 211110006056 putative substrate binding site [chemical binding]; other site 211110006057 putative ATP binding site [chemical binding]; other site 211110006058 galactose-6-phosphate isomerase subunit LacB; Reviewed; Region: PRK08622 211110006059 galactose-6-phosphate isomerase subunit LacA; Reviewed; Region: PRK08621 211110006060 Sialidases or neuraminidases function to bind and hydrolyze terminal sialic acid residues from various glycoconjugates as well as playing roles in pathogenesis, bacterial nutrition and cellular interactions. They have a six-bladed, beta-propeller fold...; Region: Sialidase; cd00260 211110006061 Sialidases or neuraminidases function to bind and hydrolyze terminal sialic acid residues from various glycoconjugates as well as playing roles in pathogenesis, bacterial nutrition and cellular interactions. They have a six-bladed, beta-propeller fold...; Region: Sialidase; cd00260 211110006062 Asp-box motif; other site 211110006063 Asp-box motif; other site 211110006064 catalytic site [active] 211110006065 Phosphotransferase system, galactitol-specific IIC component [Carbohydrate transport and metabolism]; Region: GatC; COG3775 211110006066 PTS system sugar-specific permease component; Region: EIIC-GAT; cl04451 211110006067 Phosphotransferase system, galactitol-specific IIB component [Carbohydrate transport and metabolism]; Region: SgaB; COG3414 211110006068 active site 211110006069 P-loop; other site 211110006070 phosphorylation site [posttranslational modification] 211110006071 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 211110006072 active site 211110006073 phosphorylation site [posttranslational modification] 211110006074 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 211110006075 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 211110006076 DNA-binding site [nucleotide binding]; DNA binding site 211110006077 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 211110006078 similar to pneumococcal histidine triad protein B precursor (C-terminal part);unknown 211110006079 streptococcal histidine triad protein; Region: strep_his_triad; TIGR01363 211110006080 Streptococcal histidine triad protein; Region: Strep_his_triad; pfam04270 211110006081 Streptococcal histidine triad protein; Region: Strep_his_triad; pfam04270 211110006082 ABC-type metal ion transport system, periplasmic component/surface adhesin [Inorganic ion transport and metabolism]; Region: LraI; COG0803 211110006083 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 211110006084 intersubunit interface [polypeptide binding]; other site 211110006085 D-Tyrosyl-tRNAtyr deacylases; a class of tRNA-dependent hydrolases which are capable of hydrolyzing the ester bond of D-Tyrosyl-tRNA reducing the level of cellular D-Tyrosine while recycling the peptidyl-tRNA; found in bacteria and in eukaryotes but not...; Region: Dtyr_deacylase; cd00563 211110006086 putative active site [active] 211110006087 dimerization interface [polypeptide binding]; other site 211110006088 putative tRNAtyr binding site [nucleotide binding]; other site 211110006089 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 211110006090 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 211110006091 Zn2+ binding site [ion binding]; other site 211110006092 Mg2+ binding site [ion binding]; other site 211110006093 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 211110006094 synthetase active site [active] 211110006095 NTP binding site [chemical binding]; other site 211110006096 metal binding site [ion binding]; metal-binding site 211110006097 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 211110006098 ACT domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876 211110006099 bifunctional 2',3'-cyclic nucleotide 2'-phosphodiesterase/3'-nucleotidase precursor protein; Reviewed; Region: PRK11907 211110006100 Escherichia coli CpdB and related proteins, N-terminal metallophosphatase domain; Region: MPP_CpdB_N; cd07410 211110006101 active site 211110006102 metal binding site [ion binding]; metal-binding site 211110006103 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 211110006104 Gram positive anchor; Region: Gram_pos_anchor; pfam00746 211110006105 flavoprotein NrdI; Provisional; Region: PRK02551 211110006106 Cellulase M and related proteins [Carbohydrate transport and metabolism]; Region: FrvX; COG1363 211110006107 M42 Peptidase, Endoglucanase-like subfamily; Region: M42_glucanase_like; cd05657 211110006108 putative oligomer interface [polypeptide binding]; other site 211110006109 putative active site [active] 211110006110 metal binding site [ion binding]; metal-binding site 211110006111 hypothetical protein; Provisional; Region: PRK06762 211110006112 ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840 211110006113 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 211110006114 Response regulator receiver domain; Region: Response_reg; pfam00072 211110006115 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 211110006116 active site 211110006117 phosphorylation site [posttranslational modification] 211110006118 intermolecular recognition site; other site 211110006119 dimerization interface [polypeptide binding]; other site 211110006120 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 211110006121 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 211110006122 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 211110006123 Predicted signal transduction protein with a C-terminal ATPase domain [Signal transduction mechanisms]; Region: COG2972 211110006124 Histidine kinase; Region: His_kinase; pfam06580 211110006125 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 211110006126 ATP binding site [chemical binding]; other site 211110006127 Mg2+ binding site [ion binding]; other site 211110006128 G-X-G motif; other site 211110006129 Phosphotransferase system, mannose/fructose/N-acetylgalactosamine-specific component IID [Carbohydrate transport and metabolism]; Region: ManZ; COG3716 211110006130 Phosphotransferase system, mannose/fructose/N-acetylgalactosamine-specific component IIC [Carbohydrate transport and metabolism]; Region: ManY; COG3715 211110006131 PTS system sorbose subfamily IIB component; Region: PTSIIB_sorb; pfam03830 211110006132 active site 211110006133 phosphorylation site [posttranslational modification] 211110006134 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cl00025 211110006135 active pocket/dimerization site; other site 211110006136 active site 211110006137 phosphorylation site [posttranslational modification] 211110006138 ABC-2 family transporter protein; Region: ABC2_membrane_2; cl17866 211110006139 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 211110006140 ABC-type multidrug transport system, ATPase component; Region: ABC_drug_resistance_like; cd03264 211110006141 Walker A/P-loop; other site 211110006142 ATP binding site [chemical binding]; other site 211110006143 Q-loop/lid; other site 211110006144 ABC transporter signature motif; other site 211110006145 Walker B; other site 211110006146 D-loop; other site 211110006147 H-loop/switch region; other site 211110006148 Predicted signal transduction protein with a C-terminal ATPase domain [Signal transduction mechanisms]; Region: COG2972 211110006149 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 211110006150 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 211110006151 active site 211110006152 phosphorylation site [posttranslational modification] 211110006153 intermolecular recognition site; other site 211110006154 dimerization interface [polypeptide binding]; other site 211110006155 LytTr DNA-binding domain; Region: LytTR; pfam04397 211110006156 Streptococcus agalactiae RgfB, part of a putative two component signal transduction system, and related proteins; Region: RgfB-like; cd09079 211110006157 putative catalytic site [active] 211110006158 putative metal binding site [ion binding]; other site 211110006159 putative phosphate binding site [ion binding]; other site 211110006160 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 211110006161 PTS system, IIBC component; Region: PTS-II-BC-unk1; TIGR02003 211110006162 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 211110006163 active site turn [active] 211110006164 phosphorylation site [posttranslational modification] 211110006165 Phosphotransferase system IIA components [Carbohydrate transport and metabolism]; Region: NagE; COG2190 211110006166 HPr interaction site; other site 211110006167 glycerol kinase (GK) interaction site [polypeptide binding]; other site 211110006168 active site 211110006169 phosphorylation site [posttranslational modification] 211110006170 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 211110006171 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 211110006172 dimer interface [polypeptide binding]; other site 211110006173 phosphorylation site [posttranslational modification] 211110006174 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 211110006175 ATP binding site [chemical binding]; other site 211110006176 Mg2+ binding site [ion binding]; other site 211110006177 G-X-G motif; other site 211110006178 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 211110006179 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 211110006180 active site 211110006181 phosphorylation site [posttranslational modification] 211110006182 intermolecular recognition site; other site 211110006183 dimerization interface [polypeptide binding]; other site 211110006184 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 211110006185 DNA binding site [nucleotide binding] 211110006186 phosphate transport system regulatory protein PhoU; Region: phoU_full; TIGR02135 211110006187 PhoU domain; Region: PhoU; pfam01895 211110006188 PhoU domain; Region: PhoU; pfam01895 211110006189 phosphate transporter ATP-binding protein; Provisional; Region: PRK14240 211110006190 ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260 211110006191 Walker A/P-loop; other site 211110006192 ATP binding site [chemical binding]; other site 211110006193 Q-loop/lid; other site 211110006194 ABC transporter signature motif; other site 211110006195 Walker B; other site 211110006196 D-loop; other site 211110006197 H-loop/switch region; other site 211110006198 phosphate ABC transporter, permease protein PstA; Region: 3a0107s02c; TIGR00974 211110006199 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 211110006200 dimer interface [polypeptide binding]; other site 211110006201 conserved gate region; other site 211110006202 putative PBP binding loops; other site 211110006203 ABC-ATPase subunit interface; other site 211110006204 ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstC; COG0573 211110006205 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 211110006206 dimer interface [polypeptide binding]; other site 211110006207 conserved gate region; other site 211110006208 putative PBP binding loops; other site 211110006209 ABC-ATPase subunit interface; other site 211110006210 PBP superfamily domain; Region: PBP_like_2; cl17296 211110006211 PBP superfamily domain; Region: PBP_like_2; cl17296 211110006212 Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190 211110006213 active site 211110006214 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1385 211110006215 RNA methyltransferase, RsmE family; Region: TIGR00046 211110006216 Ribosomal protein L11 methyltransferase (PrmA); Region: PrmA; pfam06325 211110006217 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 211110006218 S-adenosylmethionine binding site [chemical binding]; other site 211110006219 MepB protein; Region: MepB; pfam08877 211110006220 Helix-Turn-Helix DNA binding domain of the transcription regulators TipAL, Mta, and SkgA; Region: HTH_TipAL-Mta; cd01106 211110006221 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 211110006222 DNA binding residues [nucleotide binding] 211110006223 dimer interface [polypeptide binding]; other site 211110006224 TipAS antibiotic-recognition domain; Region: TipAS; pfam07739 211110006225 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 211110006226 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 211110006227 Coenzyme A binding pocket [chemical binding]; other site 211110006228 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_23; cd04682 211110006229 nudix motif; other site 211110006230 ASC-1 homology or ASCH domain, a small beta-barrel domain found in all three kingdoms of life. ASCH resembles the RNA-binding PUA domain and may also interact with RNA. ASCH has been proposed to function as an RNA-binding domain during coactivation; Region: ASCH; cl01020 211110006231 Protein of unknown function (DUF3013); Region: DUF3013; pfam11217 211110006232 putative acetyltransferase; Provisional; Region: PRK03624 211110006233 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 211110006234 recombination factor protein RarA; Reviewed; Region: PRK13342 211110006235 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 211110006236 Walker A motif; other site 211110006237 ATP binding site [chemical binding]; other site 211110006238 Walker B motif; other site 211110006239 arginine finger; other site 211110006240 MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002 211110006241 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 211110006242 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 211110006243 non-specific DNA binding site [nucleotide binding]; other site 211110006244 salt bridge; other site 211110006245 sequence-specific DNA binding site [nucleotide binding]; other site 211110006246 37-kD nucleoid-associated bacterial protein; Region: NA37; cl15473 211110006247 Predicted transcriptional regulator [Transcription]; Region: COG2378 211110006248 HTH domain; Region: HTH_11; pfam08279 211110006249 WYL domain; Region: WYL; pfam13280 211110006250 WXG100 family type VII secretion target; Region: WXG100_ESAT6; TIGR03930 211110006251 Protein of unknown function (DUF1310); Region: DUF1310; pfam07006 211110006252 RelB antitoxin; Region: RelB; cl01171 211110006253 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cd00267 211110006254 Walker A/P-loop; other site 211110006255 ATP binding site [chemical binding]; other site 211110006256 Q-loop/lid; other site 211110006257 ABC transporter signature motif; other site 211110006258 Walker B; other site 211110006259 D-loop; other site 211110006260 Streptomycin adenylyltransferase; Region: Adenyl_transf; pfam04439 211110006261 Protein of unknown function (DUF2785); Region: DUF2785; pfam10978 211110006262 Protein of unknown function (DUF2812); Region: DUF2812; pfam11193 211110006263 Predicted transcriptional regulators [Transcription]; Region: COG1695 211110006264 Transcriptional regulator PadR-like family; Region: PadR; cl17335 211110006265 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 211110006266 Coenzyme A binding pocket [chemical binding]; other site 211110006267 ABC-type transport system involved in multi-copper enzyme maturation, permease component [General function prediction only]; Region: NosY; COG1277 211110006268 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 211110006269 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 211110006270 Walker A/P-loop; other site 211110006271 ATP binding site [chemical binding]; other site 211110006272 Q-loop/lid; other site 211110006273 ABC transporter signature motif; other site 211110006274 Walker B; other site 211110006275 D-loop; other site 211110006276 H-loop/switch region; other site 211110006277 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 211110006278 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 211110006279 non-specific DNA binding site [nucleotide binding]; other site 211110006280 salt bridge; other site 211110006281 sequence-specific DNA binding site [nucleotide binding]; other site 211110006282 PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392 211110006283 active site 211110006284 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain superfamily; Region: NTP-PPase; cd11523 211110006285 metal binding site [ion binding]; metal-binding site 211110006286 Possible lysine decarboxylase; Region: Lysine_decarbox; cl00695 211110006287 CAAX protease self-immunity; Region: Abi; pfam02517 211110006288 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 211110006289 active site residue [active] 211110006290 CAMP factor (Cfa); Region: CAMP_factor; pfam07373 211110006291 topology modulation protein; Provisional; Region: PRK07261 211110006292 Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cd02019 211110006293 active site 211110006294 Glycerol dehydrogenase and related enzymes [Energy production and conversion]; Region: GldA; COG0371 211110006295 Glycerol dehydrogenase-like; Region: GlyDH-like2; cd08171 211110006296 putative active site [active] 211110006297 metal binding site [ion binding]; metal-binding site 211110006298 Protein of unknown function (DUF1003); Region: DUF1003; pfam06210 211110006299 bifunctional homocysteine S-methyltransferase/5,10-methylenetetrahydrofolate reductase protein; Reviewed; Region: PRK08645 211110006300 Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; cl14105 211110006301 Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cd00537 211110006302 FAD binding site [chemical binding]; other site 211110006303 5-methyltetrahydropteroyltriglutamate--homocysteine S-methyltransferase; Provisional; Region: PRK05222 211110006304 CIMS - Cobalamine-independent methonine synthase, or MetE, N-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_N_terminal_like; cd03312 211110006305 THF binding site; other site 211110006306 CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311 211110006307 substrate binding site [chemical binding]; other site 211110006308 THF binding site; other site 211110006309 zinc-binding site [ion binding]; other site 211110006310 Predicted membrane protein [Function unknown]; Region: COG4392 211110006311 Predicted branched-chain amino acid permease (azaleucine resistance) [Amino acid transport and metabolism]; Region: AzlC; COG1296 211110006312 YSIRK type signal peptide; Region: YSIRK_signal; pfam04650 211110006313 Peptidase S8 family domain in Streptococcal C5a peptidases; Region: Peptidases_S8_C5a_Peptidase; cd07475 211110006314 putative active site [active] 211110006315 catalytic triad [active] 211110006316 PA_C5a_like: Protease-associated domain containing proteins like Streptococcus pyogenes C5a peptidase. This group contains various PA domain-containing proteins similar to S. pyogenes C5a, including, i) Vpr, a minor extracellular serine protease from...; Region: PA_C5a_like; cd02133 211110006317 putative integrin binding motif; other site 211110006318 PA/protease domain interface [polypeptide binding]; other site 211110006319 Peptidase S8 family domain in Streptococcal C5a peptidases; Region: Peptidases_S8_C5a_Peptidase; cd07475 211110006320 Fn3-like domain (DUF1034); Region: DUF1034; pfam06280 211110006321 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 211110006322 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 211110006323 active site 211110006324 phosphorylation site [posttranslational modification] 211110006325 intermolecular recognition site; other site 211110006326 dimerization interface [polypeptide binding]; other site 211110006327 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 211110006328 DNA binding site [nucleotide binding] 211110006329 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 211110006330 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 211110006331 dimer interface [polypeptide binding]; other site 211110006332 phosphorylation site [posttranslational modification] 211110006333 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 211110006334 ATP binding site [chemical binding]; other site 211110006335 Mg2+ binding site [ion binding]; other site 211110006336 G-X-G motif; other site 211110006337 leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390 211110006338 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 211110006339 HIGH motif; other site 211110006340 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 211110006341 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 211110006342 active site 211110006343 KMSKS motif; other site 211110006344 Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958 211110006345 tRNA binding surface [nucleotide binding]; other site 211110006346 benzoate transport; Region: 2A0115; TIGR00895 211110006347 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 211110006348 putative substrate translocation pore; other site 211110006349 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: COG4667 211110006350 Hypothetical patatin similar to yjju protein of Escherichia coli; Region: Pat_hypo_Ecoli_yjju_like; cd07208 211110006351 active site 211110006352 nucleophile elbow; other site 211110006353 A4GalT_like proteins catalyze the addition of galactose or glucose residues to the lipooligosaccharide (LOS) or lipopolysaccharide (LPS) of the bacterial cell surface; Region: GT8_A4GalT_like; cd04194 211110006354 Glycosyl transferase family 8; Region: Glyco_transf_8; pfam01501 211110006355 Ligand binding site; other site 211110006356 metal-binding site 211110006357 A4GalT_like proteins catalyze the addition of galactose or glucose residues to the lipooligosaccharide (LOS) or lipopolysaccharide (LPS) of the bacterial cell surface; Region: GT8_A4GalT_like; cd04194 211110006358 Glycosyl transferase family 8; Region: Glyco_transf_8; pfam01501 211110006359 Ligand binding site; other site 211110006360 metal-binding site 211110006361 transcription antitermination protein NusG; Validated; Region: nusG; PRK05609 211110006362 Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891 211110006363 putative homodimer interface [polypeptide binding]; other site 211110006364 NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091 211110006365 heterodimer interface [polypeptide binding]; other site 211110006366 homodimer interface [polypeptide binding]; other site 211110006367 YSIRK type signal peptide; Region: YSIRK_signal; cl04650 211110006368 Gram positive anchor; Region: Gram_pos_anchor; pfam00746 211110006369 Preprotein translocase subunit SecE [Intracellular trafficking and secretion]; Region: SecE; COG0690 211110006370 Transglycosylase; Region: Transgly; pfam00912 211110006371 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 211110006372 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 211110006373 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 211110006374 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 211110006375 active site 211110006376 Predicted membrane protein [Function unknown]; Region: COG4640 211110006377 phosphopentomutase; Provisional; Region: PRK05362 211110006378 Metalloenzyme superfamily; Region: Metalloenzyme; pfam01676 211110006379 2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family; Region: DeoC; cd00959 211110006380 intersubunit interface [polypeptide binding]; other site 211110006381 active site 211110006382 catalytic residue [active] 211110006383 Nucleoside permease [Nucleotide transport and metabolism]; Region: NupC; COG1972 211110006384 Na+ dependent nucleoside transporter N-terminus; Region: Nucleos_tra2_N; pfam01773 211110006385 Nucleoside recognition; Region: Gate; pfam07670 211110006386 Na+ dependent nucleoside transporter C-terminus; Region: Nucleos_tra2_C; pfam07662 211110006387 Uridine phosphorylase [Nucleotide transport and metabolism]; Region: Udp; COG2820 211110006388 Phosphorylase superfamily; Region: PNP_UDP_1; cl00303 211110006389 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 211110006390 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 211110006391 DNA-binding site [nucleotide binding]; DNA binding site 211110006392 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 211110006393 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 211110006394 ring oligomerisation interface [polypeptide binding]; other site 211110006395 ATP/Mg binding site [chemical binding]; other site 211110006396 stacking interactions; other site 211110006397 hinge regions; other site 211110006398 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 211110006399 oligomerisation interface [polypeptide binding]; other site 211110006400 mobile loop; other site 211110006401 roof hairpin; other site 211110006402 ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: PhnK; COG1101 211110006403 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 211110006404 Walker A/P-loop; other site 211110006405 ATP binding site [chemical binding]; other site 211110006406 Q-loop/lid; other site 211110006407 ABC transporter signature motif; other site 211110006408 Walker B; other site 211110006409 D-loop; other site 211110006410 H-loop/switch region; other site 211110006411 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 211110006412 Transmembrane subunit (TM) of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which are involved in the uptake of branched-chain amino acids (AAs), as well as TMs of transporters involved in the uptake of...; Region: TM_PBP1_branched-chain-AA_like; cd06574 211110006413 TM-ABC transporter signature motif; other site 211110006414 Type I periplasmic ligand-binding domain of uncharacterized ABC-type transport systems that are predicted to be involved in the uptake of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_uncharacterized_transporter; cd06325 211110006415 zinc binding site [ion binding]; other site 211110006416 putative ligand binding site [chemical binding]; other site 211110006417 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 211110006418 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 211110006419 active site 211110006420 motif I; other site 211110006421 motif II; other site 211110006422 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cl17915 211110006423 Predicted ring-cleavage extradiol dioxygenase [General function prediction only]; Region: COG2514 211110006424 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_12; cd07255 211110006425 putative metal binding site [ion binding]; other site 211110006426 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 211110006427 hypothetical protein; Validated; Region: PRK02101 211110006428 4Fe-4S single cluster domain; Region: Fer4_12; pfam13353 211110006429 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 211110006430 FeS/SAM binding site; other site 211110006431 Predicted acetyltransferase [General function prediction only]; Region: COG3981 211110006432 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 211110006433 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 211110006434 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 211110006435 anaerobic ribonucleoside triphosphate reductase; Provisional; Region: PRK09263 211110006436 ATP cone domain; Region: ATP-cone; pfam03477 211110006437 Class III ribonucleotide reductase; Region: RNR_III; cd01675 211110006438 effector binding site; other site 211110006439 active site 211110006440 Zn binding site [ion binding]; other site 211110006441 glycine loop; other site 211110006442 Predicted membrane protein (DUF2079); Region: DUF2079; pfam09852 211110006443 hypothetical protein; Provisional; Region: PRK13678 211110006444 Holliday junction resolvase-like protein; Reviewed; Region: PRK00109 211110006445 hypothetical protein; Provisional; Region: PRK05473 211110006446 Arsenate Reductase (ArsC) family, Spx subfamily; Spx is a unique RNA polymerase (RNAP)-binding protein present in bacilli and some mollicutes. It inhibits transcription by binding to the C-terminal domain of the alpha subunit of RNAP, disrupting complex...; Region: ArsC_Spx; cd03032 211110006447 ArsC family; Region: ArsC; pfam03960 211110006448 putative catalytic residues [active] 211110006449 thiol/disulfide switch; other site 211110006450 recombinase A; Provisional; Region: recA; PRK09354 211110006451 RecA is a bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response. RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983 211110006452 hexamer interface [polypeptide binding]; other site 211110006453 Walker A motif; other site 211110006454 ATP binding site [chemical binding]; other site 211110006455 Walker B motif; other site 211110006456 competence damage-inducible protein A; Provisional; Region: PRK00549 211110006457 Competence-damaged protein. CinA is the first gene in the competence- inducible (cin) operon and is thought to be specifically required at some stage in the process of transformation. This domain is closely related to a domain, found in a variety of...; Region: cinA; cd00885 211110006458 putative MPT binding site; other site 211110006459 Uncharacterized protein (competence- and mitomycin-induced) [General function prediction only]; Region: CinA; COG1546 211110006460 Methyladenine glycosylase; Region: Adenine_glyco; pfam03352 211110006461 Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116 211110006462 RuvA N terminal domain; Region: RuvA_N; pfam01330 211110006463 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 211110006464 Major Facilitator Superfamily; Region: MFS_1; pfam07690 211110006465 putative substrate translocation pore; other site 211110006466 DNA mismatch repair protein; Reviewed; Region: mutL; PRK00095 211110006467 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 211110006468 ATP binding site [chemical binding]; other site 211110006469 Mg2+ binding site [ion binding]; other site 211110006470 G-X-G motif; other site 211110006471 MutL_Trans: transducer domain, having a ribosomal S5 domain 2-like fold, conserved in the C-terminal domain of DNA mismatch repair (MutL/MLH1/PMS2) family. This transducer domain is homologous to the second domain of the DNA gyrase B subunit, which is...; Region: MutL_Trans; cd00782 211110006472 ATP binding site [chemical binding]; other site 211110006473 MutL C terminal dimerisation domain; Region: MutL_C; pfam08676 211110006474 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 211110006475 DNA-binding site [nucleotide binding]; DNA binding site 211110006476 RNA-binding motif; other site 211110006477 DNA mismatch repair protein MutS; Provisional; Region: PRK05399 211110006478 MutS domain I; Region: MutS_I; pfam01624 211110006479 MutS domain II; Region: MutS_II; pfam05188 211110006480 MutS domain III; Region: MutS_III; pfam05192 211110006481 ATP-binding cassette domain of MutS1 homolog; Region: ABC_MutS1; cd03284 211110006482 Walker A/P-loop; other site 211110006483 ATP binding site [chemical binding]; other site 211110006484 Q-loop/lid; other site 211110006485 ABC transporter signature motif; other site 211110006486 Walker B; other site 211110006487 D-loop; other site 211110006488 H-loop/switch region; other site 211110006489 Arginine repressor, DNA binding domain; Region: Arg_repressor; pfam01316 211110006490 arginine repressor; Region: argR_whole; TIGR01529 211110006491 Arginine repressor, C-terminal domain; Region: Arg_repressor_C; pfam02863 211110006492 arginyl-tRNA synthetase; Reviewed; Region: PRK12451 211110006493 Arginyl tRNA synthetase N terminal dom; Region: Arg_tRNA_synt_N; smart01016 211110006494 catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671 211110006495 active site 211110006496 HIGH motif; other site 211110006497 KMSK motif region; other site 211110006498 Anticodon-binding domain of arginyl tRNA synthetases; Region: Anticodon_Ia_Arg; cd07956 211110006499 tRNA binding surface [nucleotide binding]; other site 211110006500 anticodon binding site; other site 211110006501 Enterocin A Immunity; Region: EntA_Immun; pfam08951 211110006502 Uncharacterized conserved protein [Function unknown]; Region: COG1284 211110006503 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 211110006504 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 211110006505 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 211110006506 Uncharacterized conserved protein [Function unknown]; Region: COG1284 211110006507 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 211110006508 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 211110006509 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 211110006510 aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476 211110006511 EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317 211110006512 dimer interface [polypeptide binding]; other site 211110006513 anticodon binding site; other site 211110006514 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777 211110006515 homodimer interface [polypeptide binding]; other site 211110006516 motif 1; other site 211110006517 active site 211110006518 motif 2; other site 211110006519 GAD domain; Region: GAD; pfam02938 211110006520 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777 211110006521 motif 3; other site 211110006522 histidyl-tRNA synthetase; Reviewed; Region: hisS; PRK00037 211110006523 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 211110006524 dimer interface [polypeptide binding]; other site 211110006525 motif 1; other site 211110006526 active site 211110006527 motif 2; other site 211110006528 HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859 211110006529 anticodon binding site; other site 211110006530 50S ribosomal protein L32; Validated; Region: rpmF; PRK01110 211110006531 50S ribosomal protein L33; Validated; Region: rpmG; PRK00595 211110006532 Predicted permease, cadmium resistance protein [Inorganic ion transport and metabolism]; Region: CadD; COG4300 211110006533 Cadmium resistance transporter; Region: Cad; pfam03596 211110006534 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 211110006535 putative DNA binding site [nucleotide binding]; other site 211110006536 putative Zn2+ binding site [ion binding]; other site 211110006537 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 211110006538 non-specific DNA binding site [nucleotide binding]; other site 211110006539 salt bridge; other site 211110006540 sequence-specific DNA binding site [nucleotide binding]; other site 211110006541 RNA polymerase sigma factor; Provisional; Region: PRK12519 211110006542 DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674 211110006543 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 211110006544 Plasmid replication protein; Region: Rep_2; pfam01719 211110006545 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 211110006546 phiLC3 phage and phage-related integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes various bacterial (mainly gram positive) and phage integrases, including those similar to Lactococcus...; Region: INT_phiLC3_C; cd01189 211110006547 Int/Topo IB signature motif; other site 211110006548 Domain of unknown function (DUF4016); Region: DUF4016; pfam13208 211110006549 similar to other proteins (C-terminal end);unknown 211110006550 hypothetical gene;Unknown 211110006551 similar to integrase, C-terminal part;unknown 211110006552 Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413 211110006553 Protein of unknown function (DUF2874); Region: DUF2874; pfam11396 211110006554 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 211110006555 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 211110006556 active site 211110006557 phosphorylation site [posttranslational modification] 211110006558 intermolecular recognition site; other site 211110006559 dimerization interface [polypeptide binding]; other site 211110006560 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 211110006561 DNA binding site [nucleotide binding] 211110006562 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 211110006563 HAMP domain; Region: HAMP; pfam00672 211110006564 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 211110006565 dimer interface [polypeptide binding]; other site 211110006566 phosphorylation site [posttranslational modification] 211110006567 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 211110006568 ATP binding site [chemical binding]; other site 211110006569 Mg2+ binding site [ion binding]; other site 211110006570 G-X-G motif; other site 211110006571 Predicted membrane protein [Function unknown]; Region: COG1288 211110006572 C4-dicarboxylate anaerobic carrier; Region: DcuC; pfam03606 211110006573 carbamate kinase; Reviewed; Region: PRK12686 211110006574 AAK_CK: Carbamate kinase (CK) catalyzes both the ATP-phosphorylation of carbamate and carbamoyl phosphate (CP) utilization with the production of ATP from ADP and CP. Both CK (this CD) and nonhomologous CP synthetase synthesize carbamoyl phosphate, an...; Region: AAK_CK; cd04235 211110006575 putative substrate binding site [chemical binding]; other site 211110006576 nucleotide binding site [chemical binding]; other site 211110006577 nucleotide binding site [chemical binding]; other site 211110006578 homodimer interface [polypeptide binding]; other site 211110006579 ornithine carbamoyltransferase; Provisional; Region: PRK04284 211110006580 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 211110006581 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 211110006582 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 211110006583 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 211110006584 ATP binding site [chemical binding]; other site 211110006585 Mg2+ binding site [ion binding]; other site 211110006586 G-X-G motif; other site 211110006587 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 211110006588 Response regulator receiver domain; Region: Response_reg; pfam00072 211110006589 active site 211110006590 phosphorylation site [posttranslational modification] 211110006591 intermolecular recognition site; other site 211110006592 dimerization interface [polypeptide binding]; other site 211110006593 YcbB domain; Region: YcbB; pfam08664 211110006594 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 211110006595 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 211110006596 Walker A/P-loop; other site 211110006597 ATP binding site [chemical binding]; other site 211110006598 Q-loop/lid; other site 211110006599 ABC transporter signature motif; other site 211110006600 Walker B; other site 211110006601 D-loop; other site 211110006602 H-loop/switch region; other site 211110006603 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 211110006604 dimer interface [polypeptide binding]; other site 211110006605 conserved gate region; other site 211110006606 ABC-ATPase subunit interface; other site 211110006607 Periplasmic glycine betaine/choline-binding (lipo)protein of an ABC-type transport system (osmoprotectant binding protein) [Cell envelope biogenesis, outer membrane]; Region: OpuBC; COG1732 211110006608 Predicted integral membrane protein [Function unknown]; Region: COG0392 211110006609 Uncharacterized conserved protein [Function unknown]; Region: COG2898 211110006610 Uncharacterized conserved protein (DUF2156); Region: DUF2156; pfam09924 211110006611 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 211110006612 Protein of unknown function (DUF1304); Region: DUF1304; pfam06993 211110006613 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061 211110006614 Predicted membrane protein [Function unknown]; Region: COG1511 211110006615 X-X-X-Leu-X-X-Gly heptad repeats; Region: xxxLxxG_by_4; TIGR03057 211110006616 YhgE/Pip C-terminal domain; Region: pip_yhgE_Cterm; TIGR03062 211110006617 probable dihydroxyacetone kinase regulator; Region: DHAK_reg; TIGR02366 211110006618 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 211110006619 Domain of unknown function (DUF4298); Region: DUF4298; pfam14131 211110006620 30S ribosomal protein S4; Validated; Region: rpsD; PRK05327 211110006621 Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163 211110006622 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 211110006623 RNA binding surface [nucleotide binding]; other site 211110006624 Uncharacterized protein conserved in bacteria [Function unknown]; Region: Veg; COG4466 211110006625 replicative DNA helicase; Provisional; Region: PRK05748 211110006626 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 211110006627 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 211110006628 Walker A motif; other site 211110006629 ATP binding site [chemical binding]; other site 211110006630 Walker B motif; other site 211110006631 DNA binding loops [nucleotide binding] 211110006632 50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137 211110006633 Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281 211110006634 Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948 211110006635 Predicted signaling protein consisting of a modified GGDEF domain and a DHH domain [Signal transduction mechanisms]; Region: COG3887 211110006636 DHH family; Region: DHH; pfam01368 211110006637 DHHA1 domain; Region: DHHA1; pfam02272 211110006638 tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA; Validated; Region: PRK05192 211110006639 NAD(FAD)-utilizing enzyme possibly involved in translation [Translation, ribosomal structure and biogenesis]; Region: Gid; COG1206 211110006640 GidA associated domain 3; Region: GIDA_assoc_3; pfam13932 211110006641 Multiple antibiotic transporter [Intracellular trafficking and secretion]; Region: MarC; COG2095 211110006642 Predicted tRNA(5-methylaminomethyl-2-thiouridylate) methyltransferase, contains the PP-loop ATPase domain [Translation, ribosomal structure and biogenesis]; Region: TrmU; COG0482 211110006643 tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998 211110006644 L-serine dehydratase, iron-sulfur-dependent, beta subunit; Region: sda_beta; TIGR00719 211110006645 Serine dehydratase beta chain; Region: SDH_beta; pfam03315 211110006646 C-terminal ACT domain of the L-serine dehydratase (LSD), iron-sulfur-dependent, beta subunit; Region: ACT_LSD; cd04903 211110006647 putative L-serine binding site [chemical binding]; other site 211110006648 Serine dehydratase alpha chain; Region: SDH_alpha; cl12120 211110006649 L-serine deaminase [Amino acid transport and metabolism]; Region: SdaA; COG1760 211110006650 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 211110006651 N-acetyl-D-glucosamine binding site [chemical binding]; other site 211110006652 catalytic residue [active] 211110006653 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 211110006654 ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619 211110006655 cobalt transporter ATP-binding subunit; Provisional; Region: cbiO; PRK13649 211110006656 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 211110006657 Walker A/P-loop; other site 211110006658 ATP binding site [chemical binding]; other site 211110006659 Q-loop/lid; other site 211110006660 ABC transporter signature motif; other site 211110006661 Walker B; other site 211110006662 D-loop; other site 211110006663 H-loop/switch region; other site 211110006664 cobalt transporter ATP-binding subunit; Provisional; Region: cbiO; PRK13650 211110006665 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 211110006666 Walker A/P-loop; other site 211110006667 ATP binding site [chemical binding]; other site 211110006668 Q-loop/lid; other site 211110006669 ABC transporter signature motif; other site 211110006670 Walker B; other site 211110006671 D-loop; other site 211110006672 H-loop/switch region; other site 211110006673 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453 211110006674 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 211110006675 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 211110006676 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 211110006677 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 211110006678 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 211110006679 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 211110006680 RNA binding surface [nucleotide binding]; other site 211110006681 recombination protein F; Reviewed; Region: recF; PRK00064 211110006682 ATP-binding cassette domain of RecF; Region: ABC_RecF; cd03242 211110006683 Walker A/P-loop; other site 211110006684 ATP binding site [chemical binding]; other site 211110006685 Q-loop/lid; other site 211110006686 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 211110006687 ABC transporter signature motif; other site 211110006688 Walker B; other site 211110006689 D-loop; other site 211110006690 H-loop/switch region; other site 211110006691 Sugar transport protein; Region: Sugar_transport; pfam06800 211110006692 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 211110006693 non-specific DNA binding site [nucleotide binding]; other site 211110006694 salt bridge; other site 211110006695 sequence-specific DNA binding site [nucleotide binding]; other site 211110006696 inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567 211110006697 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 211110006698 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein. IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a...; Region: CBS_pair_IMPDH; cd04601 211110006699 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 211110006700 active site 211110006701 Arginine repressor [Transcription]; Region: ArgR; COG1438 211110006702 Arginine repressor, DNA binding domain; Region: Arg_repressor; pfam01316 211110006703 Arginine repressor, C-terminal domain; Region: Arg_repressor_C; pfam02863 211110006704 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 211110006705 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 211110006706 ligand binding site [chemical binding]; other site 211110006707 flexible hinge region; other site 211110006708 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 211110006709 non-specific DNA interactions [nucleotide binding]; other site 211110006710 DNA binding site [nucleotide binding] 211110006711 sequence specific DNA binding site [nucleotide binding]; other site 211110006712 putative cAMP binding site [chemical binding]; other site 211110006713 Solo B3/4 domain (OB-fold DNA/RNA-binding) of Phe-aaRS-beta [General function prediction only]; Region: COG3382 211110006714 B3/4 domain; Region: B3_4; pfam03483 211110006715 arginine deiminase; Provisional; Region: PRK01388 211110006716 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 211110006717 Coenzyme A binding pocket [chemical binding]; other site 211110006718 ornithine carbamoyltransferase; Validated; Region: PRK02102 211110006719 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 211110006720 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 211110006721 arginine-ornithine antiporter; Region: arg_ornith_anti; TIGR03810 211110006722 carbamate kinase; Reviewed; Region: PRK12686 211110006723 AAK_CK: Carbamate kinase (CK) catalyzes both the ATP-phosphorylation of carbamate and carbamoyl phosphate (CP) utilization with the production of ATP from ADP and CP. Both CK (this CD) and nonhomologous CP synthetase synthesize carbamoyl phosphate, an...; Region: AAK_CK; cd04235 211110006724 putative substrate binding site [chemical binding]; other site 211110006725 nucleotide binding site [chemical binding]; other site 211110006726 nucleotide binding site [chemical binding]; other site 211110006727 homodimer interface [polypeptide binding]; other site 211110006728 tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282 211110006729 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 211110006730 active site 211110006731 HIGH motif; other site 211110006732 dimer interface [polypeptide binding]; other site 211110006733 KMSKS motif; other site 211110006734 Protein of unknown function (DUF1275); Region: DUF1275; pfam06912 211110006735 Uncharacterized conserved protein [Function unknown]; Region: COG1284 211110006736 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 211110006737 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 211110006738 ABC transporter ATP-binding protein; Provisional; Region: PRK15064 211110006739 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 211110006740 Walker A/P-loop; other site 211110006741 ATP binding site [chemical binding]; other site 211110006742 Q-loop/lid; other site 211110006743 ABC transporter signature motif; other site 211110006744 Walker B; other site 211110006745 D-loop; other site 211110006746 H-loop/switch region; other site 211110006747 ABC transporter; Region: ABC_tran_2; pfam12848 211110006748 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 211110006749 Bacterial membrane protein YfhO; Region: YfhO; pfam09586 211110006750 rRNA large subunit methyltransferase; Provisional; Region: PRK00103 211110006751 periplasmic serine pepetdase DegS; Region: protease_degS; TIGR02038 211110006752 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 211110006753 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 211110006754 protein binding site [polypeptide binding]; other site 211110006755 ParB/RepB/Spo0J family partition protein; Region: parB_part; TIGR00180 211110006756 ParB-like nuclease domain; Region: ParBc; pfam02195 211110006757 Sugar-specific transcriptional regulator TrmB; Region: TrmB; cl17775