-- dump date   	20140620_081607
-- class       	Genbank::misc_feature
-- table       	misc_feature_note
-- id	note
1247189000001	chromosomal replication initiation protein; Reviewed; Region: dnaA; PRK00149
1247189000002	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1247189000003	Walker A motif; other site
1247189000004	ATP binding site [chemical binding]; other site
1247189000005	Walker B motif; other site
1247189000006	arginine finger; other site
1247189000007	C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571
1247189000008	DnaA box-binding interface [nucleotide binding]; other site
1247189000009	DNA polymerase III subunit beta; Validated; Region: PRK05643
1247189000010	Beta clamp domain.  The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria.  The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140
1247189000011	putative DNA binding surface [nucleotide binding]; other site
1247189000012	dimer interface [polypeptide binding]; other site
1247189000013	beta-clamp/clamp loader binding surface; other site
1247189000014	beta-clamp/translesion DNA polymerase binding surface; other site
1247189000015	Bacterial protein of unknown function (DUF951); Region: DUF951; pfam06107
1247189000016	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
1247189000017	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
1247189000018	non-specific DNA binding site [nucleotide binding]; other site
1247189000019	salt bridge; other site
1247189000020	sequence-specific DNA binding site [nucleotide binding]; other site
1247189000021	GTP-binding protein YchF; Reviewed; Region: PRK09601
1247189000022	YchF GTPase; Region: YchF; cd01900
1247189000023	G1 box; other site
1247189000024	GTP/Mg2+ binding site [chemical binding]; other site
1247189000025	Switch I region; other site
1247189000026	G2 box; other site
1247189000027	Switch II region; other site
1247189000028	G3 box; other site
1247189000029	G4 box; other site
1247189000030	G5 box; other site
1247189000031	TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867
1247189000032	Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462
1247189000033	putative active site [active]
1247189000034	catalytic residue [active]
1247189000035	Transcription-repair coupling factor (superfamily II helicase) [DNA replication, recombination, and repair / Transcription]; Region: Mfd; COG1197
1247189000036	CarD-like/TRCF domain; Region: CarD_TRCF; smart01058
1247189000037	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
1247189000038	ATP binding site [chemical binding]; other site
1247189000039	putative Mg++ binding site [ion binding]; other site
1247189000040	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
1247189000041	nucleotide binding region [chemical binding]; other site
1247189000042	ATP-binding site [chemical binding]; other site
1247189000043	This domain is found in proteins necessary for strand-specific repair in DNA such as TRCF in Escherichia coli; Region: TRCF; smart00982
1247189000044	Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244
1247189000045	Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326
1247189000046	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
1247189000047	RNA binding surface [nucleotide binding]; other site
1247189000048	Septum formation initiator [Cell division and chromosome partitioning]; Region: COG2919
1247189000049	Septum formation initiator; Region: DivIC; pfam04977
1247189000050	Beta-lactamase class A [Defense mechanisms]; Region: PenP; COG2367
1247189000051	Beta-lactamase enzyme family; Region: Beta-lactamase2; pfam13354
1247189000052	tRNA(Ile)-lysidine synthase MesJ [Cell cycle control, cell division, chromosome partitioning]; Region: MesJ; COG0037
1247189000053	N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992
1247189000054	Ligand Binding Site [chemical binding]; other site
1247189000055	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
1247189000056	active site
1247189000057	ATP-dependent Zn proteases [Posttranslational modification, protein turnover, chaperones]; Region: HflB; COG0465
1247189000058	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1247189000059	Walker A motif; other site
1247189000060	ATP binding site [chemical binding]; other site
1247189000061	Walker B motif; other site
1247189000062	arginine finger; other site
1247189000063	Peptidase family M41; Region: Peptidase_M41; pfam01434
1247189000064	amino acid transporter; Region: 2A0306; TIGR00909
1247189000065	C-terminus of AA_permease; Region: AA_permease_C; pfam13906
1247189000066	Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826
1247189000067	Integrase core domain; Region: rve; pfam00665
1247189000068	Helix-turn-helix domain; Region: HTH_38; pfam13936
1247189000069	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3883
1247189000070	Surface antigen [General function prediction only]; Region: COG3942
1247189000071	CHAP domain; Region: CHAP; pfam05257
1247189000072	ribose-phosphate pyrophosphokinase; Provisional; Region: PRK02269
1247189000073	N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793
1247189000074	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
1247189000075	active site
1247189000076	Recombination protein O N terminal; Region: RecO_N; pfam11967
1247189000077	DNA repair protein RecO; Region: reco; TIGR00613
1247189000078	Recombination protein O C terminal; Region: RecO_C; pfam02565
1247189000079	putative phosphate acyltransferase; Provisional; Region: PRK05331
1247189000080	acyl carrier protein; Provisional; Region: PRK12449
1247189000081	phosphoribosylaminoimidazole-succinocarboxamide synthase; Reviewed; Region: PRK09362
1247189000082	bacterial and archaeal 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_PurC; cd01415
1247189000083	ATP binding site [chemical binding]; other site
1247189000084	active site
1247189000085	substrate binding site [chemical binding]; other site
1247189000086	phosphoribosylformylglycinamidine synthase, clade II; Region: FGAM-synthase; TIGR01857
1247189000087	AIR (aminoimidazole ribonucleotide) synthase related protein. This family includes Hydrogen expression/formation protein HypE, AIR synthases, FGAM (formylglycinamidine ribonucleotide) synthase and Selenophosphate synthetase (SelD). The N-terminal domain...; Region: PurM-like; cl10019
1247189000088	PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203
1247189000089	dimerization interface [polypeptide binding]; other site
1247189000090	ATP binding site [chemical binding]; other site
1247189000091	PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat2; cd02204
1247189000092	dimerization interface [polypeptide binding]; other site
1247189000093	ATP binding site [chemical binding]; other site
1247189000094	Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740
1247189000095	putative active site [active]
1247189000096	catalytic triad [active]
1247189000097	amidophosphoribosyltransferase; Provisional; Region: PRK07272
1247189000098	Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of  glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715
1247189000099	active site
1247189000100	tetramer interface [polypeptide binding]; other site
1247189000101	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
1247189000102	active site
1247189000103	phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385
1247189000104	PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196
1247189000105	dimerization interface [polypeptide binding]; other site
1247189000106	putative ATP binding site [chemical binding]; other site
1247189000107	phosphoribosylglycinamide formyltransferase; Reviewed; Region: purN; PRK05647
1247189000108	Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645
1247189000109	active site
1247189000110	substrate binding site [chemical binding]; other site
1247189000111	cosubstrate binding site; other site
1247189000112	catalytic site [active]
1247189000113	VanZ like family; Region: VanZ; pfam04892
1247189000114	bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881
1247189000115	Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal  ATIC formylase domain that formylates...; Region: IMPCH; cd01421
1247189000116	purine monophosphate binding site [chemical binding]; other site
1247189000117	dimer interface [polypeptide binding]; other site
1247189000118	putative catalytic residues [active]
1247189000119	AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; smart00798
1247189000120	AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; cl03362
1247189000121	Surface antigen [General function prediction only]; Region: COG3942
1247189000122	CHAP domain; Region: CHAP; pfam05257
1247189000123	Bacterial SH3 domain; Region: SH3_5; pfam08460
1247189000124	phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885
1247189000125	Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844
1247189000126	Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Region: GARS_A; pfam01071
1247189000127	Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843
1247189000128	Phosphoribosylcarboxyaminoimidazole (NCAIR) mutase [Nucleotide transport and metabolism]; Region: PurE; COG0041
1247189000129	phosphoribosylaminoimidazole carboxylase ATPase subunit; Reviewed; Region: PRK06019
1247189000130	ATP-grasp domain; Region: ATP-grasp_4; cl17255
1247189000131	The enzymes of glycosyl hydrolase family 31 (GH31) occur in prokaryotes, eukaryotes, and archaea with a wide range of hydrolytic activities, including alpha-glucosidase (glucoamylase and sucrase-isomaltase), alpha-xylosidase, 6-alpha-glucosyltransferase; Region: GH31; cl11402
1247189000132	adenylosuccinate lyase; Provisional; Region: PRK07492
1247189000133	Adenylsuccinate lyase (ASL)_subgroup 1; Region: Adenylsuccinate_lyase_1; cd01360
1247189000134	tetramer interface [polypeptide binding]; other site
1247189000135	active site
1247189000136	Adenylosuccinate lyase C-terminus; Region: ADSL_C; smart00998
1247189000137	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
1247189000138	non-specific DNA binding site [nucleotide binding]; other site
1247189000139	salt bridge; other site
1247189000140	sequence-specific DNA binding site [nucleotide binding]; other site
1247189000141	Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080
1247189000142	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1247189000143	Walker A motif; other site
1247189000144	ATP binding site [chemical binding]; other site
1247189000145	Walker B motif; other site
1247189000146	arginine finger; other site
1247189000147	Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491
1247189000148	Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394
1247189000149	Low molecular weight phosphatase family; Region: LMWPc; cd00115
1247189000150	active site
1247189000151	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4642
1247189000152	MORN repeat; Region: MORN; cl14787
1247189000153	Predicted acyltransferases [Lipid metabolism]; Region: COG1835
1247189000154	glucans biosynthesis protein; Provisional; Region: opgC; PRK03854
1247189000155	yrhL-like subfamily of SGNH-hydrolases, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase_yrhL_like; cd01840
1247189000156	catalytic triad [active]
1247189000157	catalytic triad [active]
1247189000158	oxyanion hole [active]
1247189000159	Coenzyme A acylating aldehyde dehydrogenase (ACDH), ALDH family 20-like; Region: ALDH_F20_ACDH; cd07122
1247189000160	putative catalytic cysteine [active]
1247189000161	NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961
1247189000162	NAD-dependent aldehyde dehydrogenases [Energy production and conversion]; Region: PutA; COG1012
1247189000163	Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454
1247189000164	C-terminal alcohol dehydrogenase domain of the acetaldehyde dehydrogenase-alcohol dehydrogenase bifunctional two-domain protein (AAD); Region: AAD_C; cd08178
1247189000165	putative active site [active]
1247189000166	metal binding site [ion binding]; metal-binding site
1247189000167	ethanol-active dehydrogenase/acetaldehyde-active reductase; Provisional; Region: PRK09422
1247189000168	Cinnamyl alcohol dehydrogenases (CAD); Region: CAD3; cd08297
1247189000169	NAD binding site [chemical binding]; other site
1247189000170	substrate binding site [chemical binding]; other site
1247189000171	catalytic Zn binding site [ion binding]; other site
1247189000172	tetramer interface [polypeptide binding]; other site
1247189000173	structural Zn binding site [ion binding]; other site
1247189000174	Threonine synthase [Amino acid transport and metabolism]; Region: ThrC; COG0498
1247189000175	Threonine synthase catalyzes the final step of threonine biosynthesis. The conversion of O-phosphohomoserine into threonine and inorganic phosphate is pyridoxal 5'-phosphate dependent. The Thr-synth_1 CD includes members from higher plants; Region: Thr-synth_2; cd01560
1247189000176	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1247189000177	catalytic residue [active]
1247189000178	Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534
1247189000179	Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Thermotoga marina NorM; Region: MATE_NorM_like; cd13137
1247189000180	Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826
1247189000181	Integrase core domain; Region: rve; pfam00665
1247189000182	Helix-turn-helix domain; Region: HTH_38; pfam13936
1247189000183	30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596
1247189000184	50S ribosomal protein L3; Validated; Region: rplC; PRK00001
1247189000185	50S ribosomal protein L4; Provisional; Region: rplD; PRK05319
1247189000186	50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738
1247189000187	50S ribosomal protein L2; Validated; Region: rplB; PRK09374
1247189000188	Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181
1247189000189	Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947
1247189000190	30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357
1247189000191	Ribosomal protein L22/L17e.  L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit.  It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336
1247189000192	putative translocon binding site; other site
1247189000193	protein-rRNA interface [nucleotide binding]; other site
1247189000194	30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310
1247189000195	K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3  is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel.  The KH...; Region: 30S_S3_KH; cd02412
1247189000196	G-X-X-G motif; other site
1247189000197	Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189
1247189000198	Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433
1247189000199	23S rRNA interface [nucleotide binding]; other site
1247189000200	5S rRNA interface [nucleotide binding]; other site
1247189000201	putative antibiotic binding site [chemical binding]; other site
1247189000202	L25 interface [polypeptide binding]; other site
1247189000203	L27 interface [polypeptide binding]; other site
1247189000204	50S ribosomal protein L29; Reviewed; Region: PRK00306
1247189000205	putative translocon interaction site; other site
1247189000206	signal recognition particle (SRP54) interaction site; other site
1247189000207	L23 interface [polypeptide binding]; other site
1247189000208	trigger factor interaction site; other site
1247189000209	30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610
1247189000210	50S ribosomal protein L14; Validated; Region: rplN; PRK05483
1247189000211	50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004
1247189000212	KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089
1247189000213	RNA binding site [nucleotide binding]; other site
1247189000214	50S ribosomal protein L5; Validated; Region: rplE; PRK00010
1247189000215	Ribosomal protein L5; Region: Ribosomal_L5; pfam00281
1247189000216	ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673
1247189000217	30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08061
1247189000218	30S ribosomal protein S8; Validated; Region: rpsH; PRK00136
1247189000219	50S ribosomal protein L6; Validated; Region: rplF; PRK05498
1247189000220	Ribosomal protein L6; Region: Ribosomal_L6; pfam00347
1247189000221	Ribosomal protein L6; Region: Ribosomal_L6; pfam00347
1247189000222	Ribosomal L18/L5e:  L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432
1247189000223	5S rRNA interface [nucleotide binding]; other site
1247189000224	L27 interface [polypeptide binding]; other site
1247189000225	23S rRNA interface [nucleotide binding]; other site
1247189000226	L5 interface [polypeptide binding]; other site
1247189000227	30S ribosomal protein S5; Validated; Region: rpsE; PRK00550
1247189000228	Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333
1247189000229	Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719
1247189000230	Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins that...; Region: Ribosomal_L30; cd01658
1247189000231	23S rRNA binding site [nucleotide binding]; other site
1247189000232	50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592
1247189000233	preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204
1247189000234	SecY translocase; Region: SecY; pfam00344
1247189000235	adenylate kinase; Reviewed; Region: adk; PRK00279
1247189000236	Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428
1247189000237	AMP-binding site [chemical binding]; other site
1247189000238	ATP-AMP (Ap5A)-binding site [chemical binding]; other site
1247189000239	S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451
1247189000240	rRNA binding site [nucleotide binding]; other site
1247189000241	predicted 30S ribosome binding site; other site
1247189000242	Ribosomal protein S13 [Translation, ribosomal structure and biogenesis]; Region: RpsM; COG0099
1247189000243	30S ribosomal protein S13; Region: bact_S13; TIGR03631
1247189000244	30S ribosomal protein S11; Validated; Region: PRK05309
1247189000245	DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182
1247189000246	N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928
1247189000247	alphaNTD homodimer interface [polypeptide binding]; other site
1247189000248	alphaNTD - beta interaction site [polypeptide binding]; other site
1247189000249	alphaNTD - beta' interaction site [polypeptide binding]; other site
1247189000250	Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118
1247189000251	50S ribosomal protein L17; Validated; Region: rplQ; PRK05591
1247189000252	Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826
1247189000253	Helix-turn-helix domain; Region: HTH_38; pfam13936
1247189000254	Integrase core domain; Region: rve; pfam00665
1247189000255	Helix-turn-helix domain; Region: HTH_38; pfam13936
1247189000256	Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826
1247189000257	Integrase core domain; Region: rve; pfam00665
1247189000258	Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826
1247189000259	Integrase core domain; Region: rve; pfam00665
1247189000260	Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447
1247189000261	nudix motif; other site
1247189000262	1,4-dihydroxy-2-naphthoate octaprenyltransferase; Validated; Region: PRK06080
1247189000263	UbiA prenyltransferase family; Region: UbiA; pfam01040
1247189000264	NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252
1247189000265	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
1247189000266	Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; pfam01654
1247189000267	cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219
1247189000268	Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322
1247189000269	thiol reductant ABC exporter, CydD subunit; Region: CydD; TIGR02857
1247189000270	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1247189000271	ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122
1247189000272	Walker A/P-loop; other site
1247189000273	ATP binding site [chemical binding]; other site
1247189000274	Q-loop/lid; other site
1247189000275	ABC transporter signature motif; other site
1247189000276	Walker B; other site
1247189000277	D-loop; other site
1247189000278	H-loop/switch region; other site
1247189000279	ABC-type transport system involved in cytochrome bd biosynthesis, fused ATPase and permease components [Energy production and conversion / Posttranslational modification, protein turnover, chaperones]; Region: CydC; COG4987
1247189000280	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
1247189000281	ATP-binding cassette domain of CydCD, subfamily C; Region: ABCC_cytochrome_bd; cd03247
1247189000282	Walker A/P-loop; other site
1247189000283	ATP binding site [chemical binding]; other site
1247189000284	Q-loop/lid; other site
1247189000285	ABC transporter signature motif; other site
1247189000286	Walker B; other site
1247189000287	D-loop; other site
1247189000288	H-loop/switch region; other site
1247189000289	Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142
1247189000290	Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685
1247189000291	substrate binding pocket [chemical binding]; other site
1247189000292	chain length determination region; other site
1247189000293	substrate-Mg2+ binding site; other site
1247189000294	catalytic residues [active]
1247189000295	aspartate-rich region 1; other site
1247189000296	active site lid residues [active]
1247189000297	aspartate-rich region 2; other site
1247189000298	4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: ipk; PRK00128
1247189000299	GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288
1247189000300	GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544
1247189000301	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
1247189000302	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
1247189000303	putative Zn2+ binding site [ion binding]; other site
1247189000304	putative DNA binding site [nucleotide binding]; other site
1247189000305	ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122
1247189000306	ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235
1247189000307	ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108
1247189000308	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
1247189000309	ABC-ATPase subunit  interface; other site
1247189000310	dimer interface [polypeptide binding]; other site
1247189000311	putative PBP binding regions; other site
1247189000312	tyrosyl-tRNA synthetase; Validated; Region: PRK05912
1247189000313	catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805
1247189000314	active site
1247189000315	HIGH motif; other site
1247189000316	dimer interface [polypeptide binding]; other site
1247189000317	KMSKS motif; other site
1247189000318	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
1247189000319	RNA binding surface [nucleotide binding]; other site
1247189000320	Membrane carboxypeptidase (penicillin-binding protein) [Cell envelope biogenesis, outer membrane]; Region: MrcB; COG0744
1247189000321	Transglycosylase; Region: Transgly; pfam00912
1247189000322	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760
1247189000323	DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405
1247189000324	RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585
1247189000325	RNA polymerase Rpb2, domain 2; Region: RNA_pol_Rpb2_2; pfam04561
1247189000326	P-loop ATPase protein family; Region: ATP_bind_2; cl15794
1247189000327	RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653
1247189000328	RPB1 interaction site [polypeptide binding]; other site
1247189000329	RPB10 interaction site [polypeptide binding]; other site
1247189000330	RPB11 interaction site [polypeptide binding]; other site
1247189000331	RPB3 interaction site [polypeptide binding]; other site
1247189000332	RPB12 interaction site [polypeptide binding]; other site
1247189000333	DNA-directed RNA polymerase subunit beta'; Provisional; Region: PRK00566
1247189000334	RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997
1247189000335	RNA polymerase I subunit A N-terminus; Region: RPOLA_N; smart00663
1247189000336	RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983
1247189000337	RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000
1247189000338	Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655
1247189000339	Rpb1 (beta') - Rpb6 (omega) interaction site [polypeptide binding]; other site
1247189000340	G-loop; other site
1247189000341	Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655
1247189000342	DNA binding site [nucleotide binding]
1247189000343	Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site
1247189000344	Protein of unknown function (DUF1033); Region: DUF1033; pfam06279
1247189000345	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
1247189000346	Walker A motif; other site
1247189000347	ATP binding site [chemical binding]; other site
1247189000348	Walker B motif; other site
1247189000349	Type II secretory pathway, component PulF [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulF; COG1459
1247189000350	Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482
1247189000351	Competence protein ComGC [Intracellular trafficking and secretion]; Region: ComGC; COG4537
1247189000352	Type II secretory pathway pseudopilin; Region: PulG; pfam11773
1247189000353	Competence protein ComGF [Intracellular trafficking and secretion]; Region: ComGF; COG4940
1247189000354	Adenine-specific DNA methylase [DNA replication, recombination, and repair]; Region: COG0827
1247189000355	Methyltransferase domain; Region: Methyltransf_26; pfam13659
1247189000356	acetate kinase A/propionate kinase 2; Reviewed; Region: PRK00180
1247189000357	propionate/acetate kinase; Provisional; Region: PRK12379
1247189000358	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
1247189000359	non-specific DNA binding site [nucleotide binding]; other site
1247189000360	salt bridge; other site
1247189000361	sequence-specific DNA binding site [nucleotide binding]; other site
1247189000362	CAAX protease self-immunity; Region: Abi; pfam02517
1247189000363	NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232
1247189000364	pyrroline-5-carboxylate reductase; Reviewed; Region: PRK11880
1247189000365	Cellulase M and related proteins [Carbohydrate transport and metabolism]; Region: FrvX; COG1363
1247189000366	M42 glutamyl aminopeptidase; Region: Peptidase_M42; cl17262
1247189000367	Cellulase M and related proteins [Carbohydrate transport and metabolism]; Region: FrvX; COG1363
1247189000368	M42 glutamyl aminopeptidase; Region: Peptidase_M42; cl17262
1247189000369	TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947
1247189000370	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
1247189000371	catalytic residues [active]
1247189000372	tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain.  PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796
1247189000373	putative tRNA-binding site [nucleotide binding]; other site
1247189000374	Methyltransferase domain; Region: Methyltransf_31; pfam13847
1247189000375	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1247189000376	S-adenosylmethionine binding site [chemical binding]; other site
1247189000377	Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629
1247189000378	SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496
1247189000379	dimer interface [polypeptide binding]; other site
1247189000380	ssDNA binding site [nucleotide binding]; other site
1247189000381	tetramer (dimer of dimers) interface [polypeptide binding]; other site
1247189000382	Type I periplasmic ligand-binding domain of uncharacterized ABC-type transport systems that are predicted to be involved in the uptake of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_uncharacterized_transporter; cd06325
1247189000383	zinc binding site [ion binding]; other site
1247189000384	putative ligand binding site [chemical binding]; other site
1247189000385	Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011
1247189000386	Type I periplasmic ligand-binding domain of uncharacterized ABC-type transport systems that are predicted to be involved in the uptake of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_uncharacterized_transporter; cd06325
1247189000387	putative ligand binding site [chemical binding]; other site
1247189000388	zinc binding site [ion binding]; other site
1247189000389	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
1247189000390	Transmembrane subunit (TM) of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which are involved in the uptake of branched-chain amino acids (AAs), as well as TMs of transporters involved in the uptake of...; Region: TM_PBP1_branched-chain-AA_like; cd06574
1247189000391	TM-ABC transporter signature motif; other site
1247189000392	Transposase; Region: DEDD_Tnp_IS110; pfam01548
1247189000393	ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: PhnK; COG1101
1247189000394	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1247189000395	Walker A/P-loop; other site
1247189000396	ATP binding site [chemical binding]; other site
1247189000397	Q-loop/lid; other site
1247189000398	ABC transporter signature motif; other site
1247189000399	Walker B; other site
1247189000400	D-loop; other site
1247189000401	H-loop/switch region; other site
1247189000402	Deoxynucleoside kinases [Nucleotide transport and metabolism]; Region: COG1428
1247189000403	Deoxyribonucleoside kinase (dNK) catalyzes the phosphorylation of deoxyribonucleosides to yield corresponding monophosphates (dNMPs). This family consists of various deoxynucleoside kinases including deoxyribo- cytidine (EC 2.7.1.74), guanosine (EC 2.7.1; Region: dNK; cd01673
1247189000404	Substrate-binding site [chemical binding]; other site
1247189000405	Substrate specificity [chemical binding]; other site
1247189000406	putative TIM-barrel protein, nifR3 family; Region: nifR3_yhdG; TIGR00737
1247189000407	Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801
1247189000408	FMN binding site [chemical binding]; other site
1247189000409	active site
1247189000410	catalytic residues [active]
1247189000411	substrate binding site [chemical binding]; other site
1247189000412	Hsp33-like chaperonin; Reviewed; Region: hslO; PRK00114
1247189000413	Heat shock protein 33 (Hsp33):  Cytosolic protein that acts as a molecular chaperone under oxidative conditions.  In normal (reducing) cytosolic conditions, four conserved Cys residues are coordinated by a Zn ion. Under oxidative stress (such as heat...; Region: Hsp33; cd00498
1247189000414	dimerization interface [polypeptide binding]; other site
1247189000415	domain crossover interface; other site
1247189000416	redox-dependent activation switch; other site
1247189000417	Mga helix-turn-helix domain; Region: Mga; pfam05043
1247189000418	M protein trans-acting positive regulator (MGA) PRD domain; Region: PRD_Mga; pfam08270
1247189000419	fimbrial isopeptide formation D2 domain; Region: RrgB_K2N_iso_D2; TIGR04226
1247189000420	Cna protein B-type domain; Region: Cna_B; pfam05738
1247189000421	Sortase C (SrtC) or subfamily-3 sortases are membrane cysteine transpeptidases found in Gram-positive bacteria that anchor surface proteins to peptidoglycans of the bacterial cell wall envelope. This involves a transpeptidation reaction in which the...; Region: Sortase_C_3; cd05827
1247189000422	active site
1247189000423	catalytic site [active]
1247189000424	Sortase C (SrtC) or subfamily-3 sortases are membrane cysteine transpeptidases found in Gram-positive bacteria that anchor surface proteins to peptidoglycans of the bacterial cell wall envelope. This involves a transpeptidation reaction in which the...; Region: Sortase_C_3; cd05827
1247189000425	active site
1247189000426	catalytic site [active]
1247189000427	Cna protein B-type domain; Region: Cna_B; pfam05738
1247189000428	Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198
1247189000429	metal ion-dependent adhesion site (MIDAS); other site
1247189000430	Cna protein B-type domain; Region: Cna_B; pfam05738
1247189000431	Sortase C (SrtC) or subfamily-3 sortases are membrane cysteine transpeptidases found in Gram-positive bacteria that anchor surface proteins to peptidoglycans of the bacterial cell wall envelope. This involves a transpeptidation reaction in which the...; Region: Sortase_C_3; cd05827
1247189000432	active site
1247189000433	catalytic site [active]
1247189000434	Sortase C (SrtC) or subfamily-3 sortases are membrane cysteine transpeptidases found in Gram-positive bacteria that anchor surface proteins to peptidoglycans of the bacterial cell wall envelope. This involves a transpeptidation reaction in which the...; Region: Sortase_C_3; cd05827
1247189000435	active site
1247189000436	catalytic site [active]
1247189000437	Cna protein B-type domain; Region: Cna_B; pfam05738
1247189000438	Cna protein B-type domain; Region: Cna_B; pfam05738
1247189000439	Cna protein B-type domain; Region: Cna_B; pfam05738
1247189000440	Cna protein B-type domain; Region: Cna_B; pfam05738
1247189000441	C-terminus of bacterial fibrinogen-binding adhesin; Region: SdrG_C_C; pfam10425
1247189000442	Cna protein B-type domain; Region: Cna_B; pfam05738
1247189000443	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2964
1247189000444	YheO-like PAS domain; Region: PAS_6; pfam08348
1247189000445	HTH domain; Region: HTH_22; pfam13309
1247189000446	YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448
1247189000447	homotrimer interaction site [polypeptide binding]; other site
1247189000448	putative active site [active]
1247189000449	Phosphotransferase system, EIIC; Region: PTS_EIIC_2; pfam13303
1247189000450	Phosphotransferase system, fructose-specific IIC component [Carbohydrate transport and metabolism]; Region: FruA; COG1299
1247189000451	Uncharacterized protein involved in tellurite resistance [Inorganic ion transport and metabolism]; Region: TelA; COG3853
1247189000452	Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788
1247189000453	Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108
1247189000454	GDP-binding site [chemical binding]; other site
1247189000455	ACT binding site; other site
1247189000456	IMP binding site; other site
1247189000457	Uncharacterized ABC-type transport system, periplasmic component/surface lipoprotein [General function prediction only]; Region: Med; COG1744
1247189000458	Periplasmic binding domain of basic membrane lipoprotein, PnrA, in Treponema pallidum and its homologs from other bacteria and Archaea; Region: PBP1_BmpA_PnrA_like; cd06354
1247189000459	ligand binding site [chemical binding]; other site
1247189000460	glycyl-radical enzyme activating protein family; Region: PFLE_PFLC; TIGR02494
1247189000461	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
1247189000462	FeS/SAM binding site; other site
1247189000463	Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349
1247189000464	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
1247189000465	DNA-binding site [nucleotide binding]; DNA binding site
1247189000466	DeoR C terminal sensor domain; Region: DeoRC; pfam00455
1247189000467	Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription]; Region: DeoR; COG2390
1247189000468	Helix-turn-helix domain; Region: HTH_28; pfam13518
1247189000469	Putative sugar-binding domain; Region: Sugar-bind; pfam04198
1247189000470	PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_lac; cd00215
1247189000471	active site
1247189000472	methionine cluster; other site
1247189000473	phosphorylation site [posttranslational modification]
1247189000474	metal binding site [ion binding]; metal-binding site
1247189000475	PTS_IIB_chitobiose_lichenan: subunit IIB of enzyme II (EII) of the N,N-diacetylchitobiose-specific and lichenan-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In these systems, EII is either a lichenan- or an N; Region: PTS_IIB_chitobiose_lichenan; cd05564
1247189000476	active site
1247189000477	P-loop; other site
1247189000478	phosphorylation site [posttranslational modification]
1247189000479	Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455
1247189000480	cellobiose phosphotransferase system IIC component; Reviewed; Region: celD; PRK09592
1247189000481	Pyruvate-formate lyase [Energy production and conversion]; Region: PflD; COG1882
1247189000482	Pyruvate formate lyase 2 and related enzymes; Region: PFL2_DhaB_BssA; cd01677
1247189000483	dimer interface [polypeptide binding]; other site
1247189000484	active site
1247189000485	glycine loop; other site
1247189000486	Transaldolase-like fructose-6-phosphate aldolases (FSA) found in bacteria and archaea; Region: Transaldolase_FSA; cd00956
1247189000487	active site
1247189000488	intersubunit interactions; other site
1247189000489	catalytic residue [active]
1247189000490	Glycerol dehydrogenase and related enzymes [Energy production and conversion]; Region: GldA; COG0371
1247189000491	Glycerol dehydrogenases (GlyDH) catalyzes oxidation of glycerol to dihydroxyacetone in glycerol dissmilation; Region: GlyDH; cd08170
1247189000492	dimer interface [polypeptide binding]; other site
1247189000493	active site
1247189000494	metal binding site [ion binding]; metal-binding site
1247189000495	Phosphatidylglycerophosphatase A; a bacterial membrane-associated enzyme involved in lipid metabolism; Region: PgpA; cd06971
1247189000496	tetramer interfaces [polypeptide binding]; other site
1247189000497	binuclear metal-binding site [ion binding]; other site
1247189000498	Microcin C7 self-immunity protein determines resistance to exogenous microcin C7; Region: Peptidase_S66_mccF_like; cd07062
1247189000499	putative dimer interface [polypeptide binding]; other site
1247189000500	catalytic triad [active]
1247189000501	This CD includes bacterial (Agrobacterium tumefaciens and Caulobacter crescentus ProX, and Clostridium sticklandii PrdX) and eukaryotic (Plasmodium falciparum N-terminal ProRS editing domain) sequences. The C. sticklandii PrdX protein, a homolog of the...; Region: PrdX_deacylase; cd04335
1247189000502	putative deacylase active site [active]
1247189000503	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
1247189000504	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
1247189000505	non-specific DNA binding site [nucleotide binding]; other site
1247189000506	salt bridge; other site
1247189000507	sequence-specific DNA binding site [nucleotide binding]; other site
1247189000508	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4529
1247189000509	FAD-NAD(P)-binding; Region: NAD_binding_9; pfam13454
1247189000510	ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488
1247189000511	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
1247189000512	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
1247189000513	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
1247189000514	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
1247189000515	ligand binding site [chemical binding]; other site
1247189000516	Predicted membrane protein [Function unknown]; Region: COG2364
1247189000517	Maf-like protein; Region: Maf; pfam02545
1247189000518	Maf_Ham1. Maf, a nucleotide binding protein, has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea. A Ham1-related protein from Methanococcus jannaschii is a novel NTPase that has been shown to hydrolyze nonstandard...; Region: Maf_Ham1; cl00276
1247189000519	putative active site [active]
1247189000520	Enterocin A Immunity; Region: EntA_Immun; pfam08951
1247189000521	Histidine phosphatase superfamily (branch 1); Region: His_Phos_1; pfam00300
1247189000522	Histidine phosphatase domain found in a functionally diverse set of proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP; cl11399
1247189000523	topology modulation protein; Provisional; Region: PRK07261
1247189000524	AAA domain; Region: AAA_17; pfam13207
1247189000525	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
1247189000526	Coenzyme A binding pocket [chemical binding]; other site
1247189000527	Radical SAM superfamily; Region: Radical_SAM; pfam04055
1247189000528	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
1247189000529	FeS/SAM binding site; other site
1247189000530	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
1247189000531	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
1247189000532	ATP-binding cassette domain of multidrug resistance protein-like transporters; Region: ABCC_MRP_Like; cd03228
1247189000533	Walker A/P-loop; other site
1247189000534	ATP binding site [chemical binding]; other site
1247189000535	Q-loop/lid; other site
1247189000536	ABC transporter signature motif; other site
1247189000537	Walker B; other site
1247189000538	D-loop; other site
1247189000539	H-loop/switch region; other site
1247189000540	Streptomycin adenylyltransferase; Region: Adenyl_transf; pfam04439
1247189000541	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
1247189000542	catalytic core [active]
1247189000543	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
1247189000544	Coenzyme A binding pocket [chemical binding]; other site
1247189000545	recombination factor protein RarA; Reviewed; Region: PRK13342
1247189000546	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1247189000547	Walker A motif; other site
1247189000548	ATP binding site [chemical binding]; other site
1247189000549	Walker B motif; other site
1247189000550	arginine finger; other site
1247189000551	MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002
1247189000552	Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743
1247189000553	Glutamine amidotransferase class-I; Region: GATase; pfam00117
1247189000554	glutamine binding [chemical binding]; other site
1247189000555	catalytic triad [active]
1247189000556	aminodeoxychorismate synthase; Provisional; Region: PRK07508
1247189000557	chorismate binding enzyme; Region: Chorismate_bind; cl10555
1247189000558	Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115
1247189000559	PyridoxaL 5'-Phosphate Dependent Enzymes class IV (PLPDE_IV). This D-amino acid superfamily, one of five classes of PLPDE, consists of branched-chain amino acid aminotransferases (BCAT), D-amino acid transferases (DAAT), and...; Region: PLPDE_IV; cl00224
1247189000560	substrate-cofactor binding pocket; other site
1247189000561	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1247189000562	catalytic residue [active]
1247189000563	Protein of unknown function (DUF3013); Region: DUF3013; pfam11217
1247189000564	Ribosomal protein L11 methyltransferase (PrmA); Region: PrmA; pfam06325
1247189000565	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1247189000566	S-adenosylmethionine binding site [chemical binding]; other site
1247189000567	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1385
1247189000568	RNA methyltransferase, RsmE family; Region: TIGR00046
1247189000569	Transcriptional regulators [Transcription]; Region: PurR; COG1609
1247189000570	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
1247189000571	DNA binding site [nucleotide binding]
1247189000572	domain linker motif; other site
1247189000573	Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011
1247189000574	Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263
1247189000575	PTS system, IIBC component; Region: PTS-II-BC-unk1; TIGR02003
1247189000576	PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212
1247189000577	active site turn [active]
1247189000578	phosphorylation site [posttranslational modification]
1247189000579	Phosphotransferase system IIA components [Carbohydrate transport and metabolism]; Region: NagE; COG2190
1247189000580	HPr interaction site; other site
1247189000581	glycerol kinase (GK) interaction site [polypeptide binding]; other site
1247189000582	active site
1247189000583	phosphorylation site [posttranslational modification]
1247189000584	Streptococcus agalactiae RgfB, part of a putative two component signal transduction system, and related proteins; Region: RgfB-like; cd09079
1247189000585	putative catalytic site [active]
1247189000586	putative metal binding site [ion binding]; other site
1247189000587	putative phosphate binding site [ion binding]; other site
1247189000588	hypothetical protein; Provisional; Region: PRK06762
1247189000589	AAA domain; Region: AAA_33; pfam13671
1247189000590	Cellulase M and related proteins [Carbohydrate transport and metabolism]; Region: FrvX; COG1363
1247189000591	M42 Peptidase, Endoglucanase-like subfamily; Region: M42_glucanase_like; cd05657
1247189000592	putative oligomer interface [polypeptide binding]; other site
1247189000593	putative active site [active]
1247189000594	metal binding site [ion binding]; metal-binding site
1247189000595	Protein of unknown function (DUF3816); Region: DUF3816; pfam12822
1247189000596	NH_3: A subgroup of nucleoside hydrolases. This group contains eukaryotic and bacterial proteins similar to nucleoside hydrolases. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the respective base. These enzymes...; Region: nuc_hydro_3; cd02653
1247189000597	active site
1247189000598	flavoprotein NrdI; Provisional; Region: PRK02551
1247189000599	M protein trans-acting positive regulator (MGA) HTH domain; Region: HTH_Mga; pfam08280
1247189000600	Mga helix-turn-helix domain; Region: Mga; pfam05043
1247189000601	M protein trans-acting positive regulator (MGA) PRD domain; Region: PRD_Mga; pfam08270
1247189000602	Chromosome segregation ATPases [Cell division and chromosome partitioning]; Region: Smc; COG1196
1247189000603	Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317
1247189000604	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
1247189000605	Zn2+ binding site [ion binding]; other site
1247189000606	Mg2+ binding site [ion binding]; other site
1247189000607	Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399
1247189000608	synthetase active site [active]
1247189000609	NTP binding site [chemical binding]; other site
1247189000610	metal binding site [ion binding]; metal-binding site
1247189000611	TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668
1247189000612	ACT  domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876
1247189000613	D-Tyrosyl-tRNAtyr deacylases; a class of tRNA-dependent hydrolases which are capable of hydrolyzing the ester bond of D-Tyrosyl-tRNA reducing the level of cellular D-Tyrosine while recycling the peptidyl-tRNA; found in bacteria and in eukaryotes but not...; Region: Dtyr_deacylase; cd00563
1247189000614	putative active site [active]
1247189000615	dimerization interface [polypeptide binding]; other site
1247189000616	putative tRNAtyr binding site [nucleotide binding]; other site
1247189000617	Staphylokinase/Streptokinase family; Region: Staphylokinase; pfam02821
1247189000618	Staphylokinase/Streptokinase family; Region: Staphylokinase; pfam02821
1247189000619	Staphylokinase/Streptokinase family; Region: Staphylokinase; pfam02821
1247189000620	Regulator of polyketide synthase expression [Signal transduction mechanisms / Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2508
1247189000621	PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556
1247189000622	The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301
1247189000623	sulfate ABC transporter, ATP-binding protein; Region: 3a0106s01; TIGR00968
1247189000624	Walker A/P-loop; other site
1247189000625	ATP binding site [chemical binding]; other site
1247189000626	Q-loop/lid; other site
1247189000627	ABC transporter signature motif; other site
1247189000628	Walker B; other site
1247189000629	D-loop; other site
1247189000630	H-loop/switch region; other site
1247189000631	TOBE domain; Region: TOBE; pfam03459
1247189000632	alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403
1247189000633	Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333
1247189000634	Ca binding site [ion binding]; other site
1247189000635	active site
1247189000636	catalytic site [active]
1247189000637	YSIRK type signal peptide; Region: YSIRK_signal; pfam04650
1247189000638	pullulanase, extracellular, Gram-positive; Region: pullulan_Gpos; TIGR02102
1247189000639	Family 41 Carbohydrate-Binding Module from pullulanase-like enzymes; Region: CBM41_pullulanase; cd10315
1247189000640	carbohydrate binding site [chemical binding]; other site
1247189000641	Family 41 Carbohydrate-Binding Module from pullulanase-like enzymes; Region: CBM41_pullulanase; cd10315
1247189000642	carbohydrate binding site [chemical binding]; other site
1247189000643	Early set domain associated with the catalytic domain of pullulanase (also called dextrinase and alpha-dextrin endo-1,6-alpha glucosidase); Region: E_set_Pullulanase; cd02860
1247189000644	Alpha amylase catalytic domain found in Pullulanase (also called dextrinase; alpha-dextrin endo-1,6-alpha glucosidase), limit dextrinase, and related proteins; Region: AmyAc_Pullulanase_LD-like; cd11341
1247189000645	Ca binding site [ion binding]; other site
1247189000646	active site
1247189000647	catalytic site [active]
1247189000648	Gram positive anchor; Region: Gram_pos_anchor; pfam00746
1247189000649	TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947
1247189000650	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
1247189000651	catalytic residues [active]
1247189000652	preprotein translocase subunit YajC; Validated; Region: yajC; PRK06531
1247189000653	Undecaprenyl pyrophosphate synthase [Lipid metabolism]; Region: UppS; COG0020
1247189000654	Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cd00475
1247189000655	catalytic residue [active]
1247189000656	putative FPP diphosphate  binding site; other site
1247189000657	putative FPP binding hydrophobic cleft; other site
1247189000658	dimer interface [polypeptide binding]; other site
1247189000659	putative IPP diphosphate binding site; other site
1247189000660	CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575
1247189000661	Cytidylyltransferase family; Region: CTP_transf_1; pfam01148
1247189000662	RIP metalloprotease RseP; Region: TIGR00054
1247189000663	RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163
1247189000664	active site
1247189000665	PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989
1247189000666	RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163
1247189000667	putative substrate binding region [chemical binding]; other site
1247189000668	prolyl-tRNA synthetase; Provisional; Region: PRK09194
1247189000669	Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA.   PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268
1247189000670	motif 1; other site
1247189000671	dimer interface [polypeptide binding]; other site
1247189000672	active site
1247189000673	motif 2; other site
1247189000674	INS is an amino acid-editing domain inserted (INS) into the bacterial class II prolyl-tRNA synthetase (ProRS) however, this CD is not exclusively bacterial. It is also found at the N-terminus of the eukaryotic/archaea-like ProRS's of yeasts and...; Region: ProRS-INS; cd04334
1247189000675	putative deacylase active site [active]
1247189000676	Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA.   PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268
1247189000677	active site
1247189000678	motif 3; other site
1247189000679	ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding; Region: ProRS_anticodon_short; cd00861
1247189000680	anticodon binding site; other site
1247189000681	Bacterial protein of unknown function (DUF925); Region: DUF925; pfam06042
1247189000682	DNA polymerase III PolC; Validated; Region: polC; PRK00448
1247189000683	DNA polymerase III polC-type N-terminus; Region: DNA_pol3_alph_N; pfam11490
1247189000684	polC_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold nucleic acid binding domain of Bacillus subtilis type C replicative DNA polymerase III alpha subunit (polC). Replication in B. subtilis and Staphylococcus aureus requires two...; Region: polC_OBF; cd04484
1247189000685	generic binding surface II; other site
1247189000686	generic binding surface I; other site
1247189000687	Polymerase and Histidinol Phosphatase domain; Region: PHP; cl17102
1247189000688	active site
1247189000689	DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127
1247189000690	active site
1247189000691	catalytic site [active]
1247189000692	substrate binding site [chemical binding]; other site
1247189000693	Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III at PolC gene; Region: PHP_PolIIIA_POLC; cd07435
1247189000694	putative PHP Thumb interface [polypeptide binding]; other site
1247189000695	active site
1247189000696	MarR family; Region: MarR_2; cl17246
1247189000697	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
1247189000698	Predicted flavoprotein [General function prediction only]; Region: COG0431
1247189000699	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
1247189000700	Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487
1247189000701	active site
1247189000702	catalytic residues [active]
1247189000703	metal binding site [ion binding]; metal-binding site
1247189000704	DNA-binding transcriptional activator YeiL; Provisional; Region: PRK10402
1247189000705	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
1247189000706	ligand binding site [chemical binding]; other site
1247189000707	helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cl17320
1247189000708	Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353
1247189000709	16S/18S rRNA binding site [nucleotide binding]; other site
1247189000710	S13e-L30e interaction site [polypeptide binding]; other site
1247189000711	25S rRNA binding site [nucleotide binding]; other site
1247189000712	Transcriptional antiterminator [Transcription]; Region: BglG; COG3711
1247189000713	PRD domain; Region: PRD; pfam00874
1247189000714	PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568
1247189000715	active site
1247189000716	P-loop; other site
1247189000717	phosphorylation site [posttranslational modification]
1247189000718	PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211
1247189000719	active site
1247189000720	phosphorylation site [posttranslational modification]
1247189000721	PTS_IIB_ascorbate: subunit IIB of enzyme II (EII) of the L-ascorbate-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is an L-ascorbate-specific permease with two cytoplasmic subunits (IIA and IIB) and a...; Region: PTS_IIB_ascorbate; cd05563
1247189000722	active site
1247189000723	P-loop; other site
1247189000724	phosphorylation site [posttranslational modification]
1247189000725	PTS system ascorbate-specific transporter subunit IIC; Reviewed; Region: ulaA; PRK09410
1247189000726	Transaldolase-like fructose-6-phosphate aldolases (FSA) found in bacteria and archaea; Region: Transaldolase_FSA; cd00956
1247189000727	intersubunit interactions; other site
1247189000728	active site
1247189000729	catalytic residue [active]
1247189000730	polynucleotide phosphorylase/polyadenylase; Provisional; Region: PRK11824
1247189000731	Polyribonucleotide nucleotidyltransferase, repeat 1; Region: RNase_PH_PNPase_1; cd11363
1247189000732	RNase E interface [polypeptide binding]; other site
1247189000733	trimer interface [polypeptide binding]; other site
1247189000734	Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364
1247189000735	RNase E interface [polypeptide binding]; other site
1247189000736	trimer interface [polypeptide binding]; other site
1247189000737	active site
1247189000738	Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393
1247189000739	S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase  is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472
1247189000740	RNA binding site [nucleotide binding]; other site
1247189000741	domain interface; other site
1247189000742	Serine acetyltransferase [Amino acid transport and metabolism]; Region: CysE; COG1045
1247189000743	Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354
1247189000744	trimer interface [polypeptide binding]; other site
1247189000745	active site
1247189000746	substrate binding site [chemical binding]; other site
1247189000747	CoA binding site [chemical binding]; other site
1247189000748	catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672
1247189000749	tRNA synthetases class I (C) catalytic domain; Region: tRNA-synt_1e; pfam01406
1247189000750	active site
1247189000751	HIGH motif; other site
1247189000752	catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672
1247189000753	KMSKS motif; other site
1247189000754	Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020
1247189000755	Ribonuclease III family protein [Replication, recombination, and    repair]; Region: COG1939
1247189000756	active site
1247189000757	metal binding site [ion binding]; metal-binding site
1247189000758	dimerization interface [polypeptide binding]; other site
1247189000759	Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515
1247189000760	rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566
1247189000761	RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032
1247189000762	SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588
1247189000763	Predicted RNA-binding protein containing a PIN domain [General function prediction only]; Region: COG3688
1247189000764	EDD domain protein, DegV family; Region: DegV; TIGR00762
1247189000765	Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645
1247189000766	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
1247189000767	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
1247189000768	non-specific DNA binding site [nucleotide binding]; other site
1247189000769	salt bridge; other site
1247189000770	sequence-specific DNA binding site [nucleotide binding]; other site
1247189000771	Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826
1247189000772	Helix-turn-helix domain; Region: HTH_38; pfam13936
1247189000773	Integrase core domain; Region: rve; pfam00665
1247189000774	Ribosomal protein L13.  Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392
1247189000775	23S rRNA interface [nucleotide binding]; other site
1247189000776	L3 interface [polypeptide binding]; other site
1247189000777	30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132
1247189000778	Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582
1247189000779	phiLC3 phage and phage-related integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes various bacterial (mainly gram positive) and phage integrases, including those similar to Lactococcus...; Region: INT_phiLC3_C; cd01189
1247189000780	Int/Topo IB signature motif; other site
1247189000781	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
1247189000782	non-specific DNA binding site [nucleotide binding]; other site
1247189000783	salt bridge; other site
1247189000784	sequence-specific DNA binding site [nucleotide binding]; other site
1247189000785	Phage DNA packaging protein Nu1; Region: Phage_Nu1; cl01720
1247189000786	N-terminal phage replisome organiser (Phage_rep_org_N); Region: Phage_rep_org_N; pfam09681
1247189000787	copper transport repressor, CopY/TcrY family; Region: CopY_TcrY; TIGR02698
1247189000788	Penicillinase repressor; Region: Pencillinase_R; pfam03965
1247189000789	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217
1247189000790	copper-(or silver)-translocating P-type ATPase; Region: ATPase-IB1_Cu; TIGR01511
1247189000791	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
1247189000792	Soluble P-type ATPase [General function prediction only]; Region: COG4087
1247189000793	Predicted permease, cadmium resistance protein [Inorganic ion transport and metabolism]; Region: CadD; COG4300
1247189000794	Cadmium resistance transporter; Region: Cad; pfam03596
1247189000795	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
1247189000796	putative DNA binding site [nucleotide binding]; other site
1247189000797	putative Zn2+ binding site [ion binding]; other site
1247189000798	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
1247189000799	active site
1247189000800	Int/Topo IB signature motif; other site
1247189000801	DNA binding site [nucleotide binding]
1247189000802	Transposase; Region: DEDD_Tnp_IS110; pfam01548
1247189000803	DNA polymerase III subunits gamma and tau; Provisional; Region: PRK14950
1247189000804	AAA-like domain; Region: AAA_10; pfam12846
1247189000805	TcpE family; Region: TcpE; pfam12648
1247189000806	Conjugative transposon protein TcpC; Region: TpcC; pfam12642
1247189000807	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
1247189000808	non-specific DNA binding site [nucleotide binding]; other site
1247189000809	salt bridge; other site
1247189000810	sequence-specific DNA binding site [nucleotide binding]; other site
1247189000811	Replication initiation factor; Region: Rep_trans; pfam02486
1247189000812	Plasmid encoded toxin Txe; Region: Plasmid_Txe; pfam06769
1247189000813	Antitoxin of toxin-antitoxin stability system [Cell division and chromosome partitioning]; Region: StbD; COG2161
1247189000814	DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674
1247189000815	FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580
1247189000816	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
1247189000817	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
1247189000818	non-specific DNA binding site [nucleotide binding]; other site
1247189000819	salt bridge; other site
1247189000820	sequence-specific DNA binding site [nucleotide binding]; other site
1247189000821	Domain of unknown function (DUF955); Region: DUF955; pfam06114
1247189000822	SOS-response transcriptional repressors (RecA-mediated autopeptidases) [Transcription / Signal transduction mechanisms]; Region: LexA; COG1974
1247189000823	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
1247189000824	sequence-specific DNA binding site [nucleotide binding]; other site
1247189000825	salt bridge; other site
1247189000826	Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529
1247189000827	Catalytic site [active]
1247189000828	Lantibiotic dehydratase, N terminus; Region: Lant_dehyd_N; pfam04737
1247189000829	Lantibiotic dehydratase, C terminus; Region: Lant_dehyd_C; pfam04738
1247189000830	thiopeptide-type bacteriocin biosynthesis domain; Region: thiopep_ocin; TIGR03891
1247189000831	LanC is the cyclase enzyme of the lanthionine synthetase. Lanthinoine is a lantibiotic, a unique class of peptide antibiotics. They are ribosomally synthesized as precursor peptides and then post-translationally modified to contain thioether cross-links...; Region: LanC; cd04793
1247189000832	Lanthionine synthetase C-like protein; Region: LANC_like; pfam05147
1247189000833	active site
1247189000834	zinc binding site [ion binding]; other site
1247189000835	H+ Antiporter protein; Region: 2A0121; TIGR00900
1247189000836	ATP-dependent DNA helicase recG C-terminal; Region: HATPase_c_4; pfam13749
1247189000837	phiLC3 phage and phage-related integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes various bacterial (mainly gram positive) and phage integrases, including those similar to Lactococcus...; Region: INT_phiLC3_C; cd01189
1247189000838	Int/Topo IB signature motif; other site
1247189000839	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
1247189000840	non-specific DNA binding site [nucleotide binding]; other site
1247189000841	salt bridge; other site
1247189000842	sequence-specific DNA binding site [nucleotide binding]; other site
1247189000843	Temperature dependent protein affecting M2 dsRNA replication; Region: MKT1_N; pfam12247
1247189000844	ATP-dependent DNA helicase recG C-terminal; Region: HATPase_c_4; pfam13749
1247189000845	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
1247189000846	haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282
1247189000847	active site
1247189000848	motif I; other site
1247189000849	motif II; other site
1247189000850	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cl17915
1247189000851	Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826
1247189000852	Helix-turn-helix domain; Region: HTH_38; pfam13936
1247189000853	Integrase core domain; Region: rve; pfam00665
1247189000854	RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937
1247189000855	aspartate kinase; Reviewed; Region: PRK09034
1247189000856	AAK_AKiii-YclM-BS: Amino Acid Kinase Superfamily (AAK), AKiii-YclM-BS; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the lysine plus threonine-sensitive aspartokinase isoenzyme AKIII, a monofunctional class enzyme found in...; Region: AAK_AKiii-YclM-BS; cd04245
1247189000857	putative catalytic residues [active]
1247189000858	putative nucleotide binding site [chemical binding]; other site
1247189000859	putative aspartate binding site [chemical binding]; other site
1247189000860	ACT domains located C-terminal to the catalytic domain of the lysine plus threonine-sensitive aspartokinase isoenzyme AKIII; Region: ACT_AKiii-YclM-BS_1; cd04911
1247189000861	allosteric regulatory residue; other site
1247189000862	ACT domains located C-terminal to the catalytic domain of the lysine plus threonine-sensitive aspartokinase isoenzyme AKIII; Region: ACT_AKiii-YclM-BS_2; cd04916
1247189000863	tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021
1247189000864	Eukaryotic and bacterial pseudouridine synthases similar to E.  coli TruA; Region: PseudoU_synth_EcTruA; cd02570
1247189000865	dimerization interface 3.5A [polypeptide binding]; other site
1247189000866	active site
1247189000867	4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169
1247189000868	dimer interface [polypeptide binding]; other site
1247189000869	substrate binding site [chemical binding]; other site
1247189000870	ATP binding site [chemical binding]; other site
1247189000871	Predicted membrane protein [Function unknown]; Region: COG4720
1247189000872	hypothetical protein; Provisional; Region: PRK13690
1247189000873	Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668
1247189000874	Mechanosensitive ion channel; Region: MS_channel; pfam00924
1247189000875	Alpha amylase catalytic domain found in bacterial Alpha-amylases (also called 1,4-alpha-D-glucan-4-glucanohydrolase); Region: AmyAc_bac1_AmyA; cd11315
1247189000876	Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366
1247189000877	active site
1247189000878	Ca binding site [ion binding]; other site
1247189000879	catalytic site [active]
1247189000880	Alpha amylase catalytic domain found in bacterial Alpha-amylases (also called 1,4-alpha-D-glucan-4-glucanohydrolase); Region: AmyAc_bac1_AmyA; cd11315
1247189000881	Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366
1247189000882	active site
1247189000883	Ca binding site [ion binding]; other site
1247189000884	catalytic site [active]
1247189000885	Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; cl02706
1247189000886	trigger factor; Provisional; Region: tig; PRK01490
1247189000887	FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254
1247189000888	Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698
1247189000889	CTP synthetase; Validated; Region: pyrG; PRK05380
1247189000890	CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113
1247189000891	Catalytic site [active]
1247189000892	active site
1247189000893	UTP binding site [chemical binding]; other site
1247189000894	Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746
1247189000895	active site
1247189000896	putative oxyanion hole; other site
1247189000897	catalytic triad [active]
1247189000898	5TMR of 5TMR-LYT; Region: 5TM-5TMR_LYT; pfam07694
1247189000899	5TMR of 5TMR-LYT; Region: 5TM-5TMR_LYT; pfam07694
1247189000900	Putative regulator of cell autolysis [Signal transduction mechanisms]; Region: LytS; COG3275
1247189000901	Histidine kinase; Region: His_kinase; pfam06580
1247189000902	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1247189000903	ATP binding site [chemical binding]; other site
1247189000904	Mg2+ binding site [ion binding]; other site
1247189000905	G-X-G motif; other site
1247189000906	two-component response regulator; Provisional; Region: PRK14084
1247189000907	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1247189000908	active site
1247189000909	phosphorylation site [posttranslational modification]
1247189000910	intermolecular recognition site; other site
1247189000911	dimerization interface [polypeptide binding]; other site
1247189000912	LytTr DNA-binding domain; Region: LytTR; smart00850
1247189000913	LrgA family; Region: LrgA; cl00608
1247189000914	antiholin-like protein LrgB; Provisional; Region: PRK04288
1247189000915	Hydrolases of the alpha/beta superfamily [General function prediction only]; Region: COG1073
1247189000916	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
1247189000917	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
1247189000918	fructose-bisphosphate aldolase; Provisional; Region: PRK09197
1247189000919	Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947
1247189000920	intersubunit interface [polypeptide binding]; other site
1247189000921	active site
1247189000922	zinc binding site [ion binding]; other site
1247189000923	Na+ binding site [ion binding]; other site
1247189000924	50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359
1247189000925	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; pfam13808
1247189000926	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
1247189000927	Transposase [DNA replication, recombination, and repair]; Region: COG5433
1247189000928	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1302
1247189000929	Predicted kinase related to dihydroxyacetone kinase [General function prediction only]; Region: COG1461
1247189000930	DAK2 domain; Region: Dak2; pfam02734
1247189000931	Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330
1247189000932	A subgroup of the band 7 domain of flotillin (reggie) like proteins. This subgroup contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin.  Many of these band 7 domain-containing proteins are lipid raft-associated.  Individual...; Region: Band_7_4; cd03407
1247189000933	ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126
1247189000934	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1247189000935	Walker A/P-loop; other site
1247189000936	ATP binding site [chemical binding]; other site
1247189000937	Q-loop/lid; other site
1247189000938	ABC transporter signature motif; other site
1247189000939	Walker B; other site
1247189000940	D-loop; other site
1247189000941	H-loop/switch region; other site
1247189000942	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
1247189000943	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
1247189000944	substrate binding pocket [chemical binding]; other site
1247189000945	membrane-bound complex binding site; other site
1247189000946	hinge residues; other site
1247189000947	ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215
1247189000948	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1247189000949	dimer interface [polypeptide binding]; other site
1247189000950	conserved gate region; other site
1247189000951	putative PBP binding loops; other site
1247189000952	ABC-ATPase subunit interface; other site
1247189000953	Predicted membrane protein (DUF2207); Region: DUF2207; pfam09972
1247189000954	undecaprenyl pyrophosphate phosphatase; Reviewed; Region: PRK00281
1247189000955	adaptor protein; Provisional; Region: PRK02315
1247189000956	UDP-N-acetylmuramyl pentapeptide phosphotransferase/UDP-N- acetylglucosamine-1-phosphate transferase [Cell envelope biogenesis, outer membrane]; Region: Rfe; COG0472
1247189000957	This subfamily contains Escherichia coli WecA, Bacillus subtilis TagO and related proteins. WecA is an UDP-N-acetylglucosamine (GlcNAc):undecaprenyl-phosphate (Und-P) GlcNAc-1-phosphate transferase that catalyzes the formation of a phosphodiester bond...; Region: GT_WecA_like; cd06853
1247189000958	Mg++ binding site [ion binding]; other site
1247189000959	putative catalytic motif [active]
1247189000960	substrate binding site [chemical binding]; other site
1247189000961	Cysteine desulfurase activator ATPase [Posttranslational modification, protein turnover, chaperones]; Region: sufC; COG0396
1247189000962	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1247189000963	Walker A/P-loop; other site
1247189000964	ATP binding site [chemical binding]; other site
1247189000965	Q-loop/lid; other site
1247189000966	ABC transporter signature motif; other site
1247189000967	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1247189000968	Walker B; other site
1247189000969	D-loop; other site
1247189000970	H-loop/switch region; other site
1247189000971	Cysteine desulfurase activator SufB [Posttranslational modification, protein turnover, chaperones]; Region: SufB; COG0719
1247189000972	FeS assembly protein SufD; Region: sufD; TIGR01981
1247189000973	Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520
1247189000974	Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453
1247189000975	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
1247189000976	catalytic residue [active]
1247189000977	NifU homolog involved in Fe-S cluster formation [Energy production and conversion]; Region: IscU; COG0822
1247189000978	Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664
1247189000979	trimerization site [polypeptide binding]; other site
1247189000980	active site
1247189000981	cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814; cl03223
1247189000982	FeS assembly protein SufB; Region: sufB; TIGR01980
1247189000983	D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768
1247189000984	Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872
1247189000985	Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872
1247189000986	D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768
1247189000987	The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504
1247189000988	peptide binding site [polypeptide binding]; other site
1247189000989	Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496
1247189000990	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601
1247189000991	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1247189000992	dimer interface [polypeptide binding]; other site
1247189000993	conserved gate region; other site
1247189000994	putative PBP binding loops; other site
1247189000995	ABC-ATPase subunit interface; other site
1247189000996	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173
1247189000997	N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911
1247189000998	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1247189000999	dimer interface [polypeptide binding]; other site
1247189001000	conserved gate region; other site
1247189001001	putative PBP binding loops; other site
1247189001002	ABC-ATPase subunit interface; other site
1247189001003	ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444
1247189001004	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
1247189001005	Walker A/P-loop; other site
1247189001006	ATP binding site [chemical binding]; other site
1247189001007	Q-loop/lid; other site
1247189001008	ABC transporter signature motif; other site
1247189001009	Walker B; other site
1247189001010	D-loop; other site
1247189001011	H-loop/switch region; other site
1247189001012	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
1247189001013	ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124
1247189001014	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
1247189001015	Walker A/P-loop; other site
1247189001016	ATP binding site [chemical binding]; other site
1247189001017	Q-loop/lid; other site
1247189001018	ABC transporter signature motif; other site
1247189001019	Walker B; other site
1247189001020	D-loop; other site
1247189001021	H-loop/switch region; other site
1247189001022	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352
1247189001023	Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826
1247189001024	Integrase core domain; Region: rve; pfam00665
1247189001025	Helix-turn-helix domain; Region: HTH_38; pfam13936
1247189001026	RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937
1247189001027	Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826
1247189001028	Integrase core domain; Region: rve; pfam00665
1247189001029	Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826
1247189001030	Helix-turn-helix domain; Region: HTH_38; pfam13936
1247189001031	Predicted hydrolase of the HAD superfamily [General function prediction only]; Region: COG2179
1247189001032	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
1247189001033	active site
1247189001034	motif I; other site
1247189001035	motif II; other site
1247189001036	GTPase YqeH; Provisional; Region: PRK13796
1247189001037	Circularly permuted YqeH GTPase; Region: YqeH; cd01855
1247189001038	GTP/Mg2+ binding site [chemical binding]; other site
1247189001039	G4 box; other site
1247189001040	G5 box; other site
1247189001041	G1 box; other site
1247189001042	Switch I region; other site
1247189001043	G2 box; other site
1247189001044	G3 box; other site
1247189001045	Switch II region; other site
1247189001046	Predicted RNA-binding protein containing KH domain, possibly ribosomal protein [Translation, ribosomal structure and biogenesis]; Region: COG1534
1247189001047	nicotinic acid mononucleotide adenylyltransferase; Provisional; Region: nadD; PRK00071
1247189001048	Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165
1247189001049	active site
1247189001050	(T/H)XGH motif; other site
1247189001051	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
1247189001052	Zn2+ binding site [ion binding]; other site
1247189001053	Mg2+ binding site [ion binding]; other site
1247189001054	Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cl00220
1247189001055	conserved cis-peptide bond; other site
1247189001056	Uncharacterized homolog of plant Iojap protein [Function unknown]; Region: COG0799
1247189001057	SAM-dependent methyltransferases [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: SmtA; COG0500
1247189001058	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1247189001059	S-adenosylmethionine binding site [chemical binding]; other site
1247189001060	hypothetical protein; Provisional; Region: PRK13670
1247189001061	HIGH Nucleotidyl Transferase; Region: HIGH_NTase1; cl17673
1247189001062	Helix-Turn-Helix DNA binding domain of the transcription regulators TipAL, Mta, and SkgA; Region: HTH_TipAL-Mta; cd01106
1247189001063	MerR HTH family regulatory protein; Region: MerR_1; pfam13411
1247189001064	DNA binding residues [nucleotide binding]
1247189001065	dimer interface [polypeptide binding]; other site
1247189001066	TipAS antibiotic-recognition domain; Region: TipAS; pfam07739
1247189001067	Streptococcal histidine triad protein; Region: Strep_his_triad; pfam04270
1247189001068	prolipoprotein diacylglyceryl transferase; Reviewed; Region: PRK13108
1247189001069	biotin synthase; Region: bioB; TIGR00433
1247189001070	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
1247189001071	FeS/SAM binding site; other site
1247189001072	Biotin and Thiamin Synthesis associated domain; Region: BATS; pfam06968
1247189001073	hypothetical protein; Provisional; Region: PRK12378
1247189001074	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
1247189001075	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
1247189001076	substrate binding pocket [chemical binding]; other site
1247189001077	membrane-bound complex binding site; other site
1247189001078	hinge residues; other site
1247189001079	NLPA lipoprotein; Region: Lipoprotein_9; cl17547
1247189001080	NLPA lipoprotein; Region: Lipoprotein_9; cl17547
1247189001081	ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464
1247189001082	NLPA lipoprotein; Region: Lipoprotein_9; pfam03180
1247189001083	Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876
1247189001084	metal binding site [ion binding]; metal-binding site
1247189001085	Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876
1247189001086	ABC transporter; Region: ABC_tran; pfam00005
1247189001087	ATP-binding cassette domain of methionine transporter; Region: ABC_MetN_methionine_transporter; cd03258
1247189001088	Q-loop/lid; other site
1247189001089	ABC-type oligopeptide transport system, ATPase component [Amino acid transport and metabolism]; Region: AppF; COG4608
1247189001090	ABC transporter signature motif; other site
1247189001091	Walker B; other site
1247189001092	D-loop; other site
1247189001093	H-loop/switch region; other site
1247189001094	NIL domain; Region: NIL; pfam09383
1247189001095	ABC-type metal ion transport system, permease component [Inorganic ion transport and metabolism]; Region: AbcD; COG2011
1247189001096	Branched-chain amino acid transport protein; Region: Branch_AA_trans; pfam05525
1247189001097	serine/threonine transporter SstT; Provisional; Region: PRK13628
1247189001098	Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301
1247189001099	K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569
1247189001100	TrkA-N domain; Region: TrkA_N; pfam02254
1247189001101	Trk-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: TrkG; COG0168
1247189001102	potassium uptake protein, TrkH family; Region: 2a38; TIGR00933
1247189001103	Predicted S-adenosylmethionine-dependent methyltransferase involved in bacterial cell division [Cell envelope biogenesis, outer membrane]; Region: GidB; COG0357
1247189001104	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1247189001105	S-adenosylmethionine binding site [chemical binding]; other site
1247189001106	Uncharacterized conserved protein [Function unknown]; Region: LemA; COG1704
1247189001107	heat shock protein HtpX; Provisional; Region: PRK04897
1247189001108	Predicted metal-binding, possibly nucleic acid-binding protein [General function prediction only]; Region: COG1399
1247189001109	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
1247189001110	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1247189001111	active site
1247189001112	phosphorylation site [posttranslational modification]
1247189001113	intermolecular recognition site; other site
1247189001114	dimerization interface [polypeptide binding]; other site
1247189001115	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
1247189001116	DNA binding site [nucleotide binding]
1247189001117	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
1247189001118	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
1247189001119	dimerization interface [polypeptide binding]; other site
1247189001120	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
1247189001121	dimer interface [polypeptide binding]; other site
1247189001122	phosphorylation site [posttranslational modification]
1247189001123	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1247189001124	ATP binding site [chemical binding]; other site
1247189001125	Mg2+ binding site [ion binding]; other site
1247189001126	G-X-G motif; other site
1247189001127	transcriptional regulator NrdR; Validated; Region: nrdR; PRK00464
1247189001128	ATP cone domain; Region: ATP-cone; pfam03477
1247189001129	Replication initiation/membrane attachment protein [DNA replication, recombination, and repair]; Region: DnaB; COG3611
1247189001130	primosomal protein DnaI; Reviewed; Region: PRK08939
1247189001131	Primosomal protein DnaI N-terminus; Region: DnaI_N; pfam07319
1247189001132	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1247189001133	Walker A motif; other site
1247189001134	ATP binding site [chemical binding]; other site
1247189001135	Walker B motif; other site
1247189001136	GTP-binding protein Der; Reviewed; Region: PRK00093
1247189001137	EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894
1247189001138	G1 box; other site
1247189001139	GTP/Mg2+ binding site [chemical binding]; other site
1247189001140	Switch I region; other site
1247189001141	G2 box; other site
1247189001142	Switch II region; other site
1247189001143	G3 box; other site
1247189001144	G4 box; other site
1247189001145	G5 box; other site
1247189001146	EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895
1247189001147	G1 box; other site
1247189001148	GTP/Mg2+ binding site [chemical binding]; other site
1247189001149	Switch I region; other site
1247189001150	G2 box; other site
1247189001151	G3 box; other site
1247189001152	Switch II region; other site
1247189001153	G4 box; other site
1247189001154	G5 box; other site
1247189001155	SWIM zinc finger; Region: SWIM; pfam04434
1247189001156	Bacterial SNF2 helicase associated; Region: SNF2_assoc; pfam08455
1247189001157	SNF2 family N-terminal domain; Region: SNF2_N; pfam00176
1247189001158	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
1247189001159	ATP binding site [chemical binding]; other site
1247189001160	putative Mg++ binding site [ion binding]; other site
1247189001161	Superfamily II DNA and RNA helicases [DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis]; Region: SrmB; COG0513
1247189001162	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
1247189001163	nucleotide binding region [chemical binding]; other site
1247189001164	ATP-binding site [chemical binding]; other site
1247189001165	UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421
1247189001166	Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225
1247189001167	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
1247189001168	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
1247189001169	Acetyltransferases [General function prediction only]; Region: RimI; COG0456
1247189001170	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
1247189001171	Coenzyme A binding pocket [chemical binding]; other site
1247189001172	Aminodeoxychorismate lyase [Coenzyme transport and metabolism]; Region: COG1559
1247189001173	proteins similar to Escherichia coli yceG; Region: yceG_like; cd08010
1247189001174	dimerization interface [polypeptide binding]; other site
1247189001175	transcription elongation factor GreA; Reviewed; Region: greA; PRK00226
1247189001176	Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449
1247189001177	Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272
1247189001178	OxaA-like protein precursor; Provisional; Region: PRK02463
1247189001179	membrane protein insertase, YidC/Oxa1 family, C-terminal domain; Region: yidC_oxa1_cterm; TIGR03592
1247189001180	acylphosphatase; Provisional; Region: PRK14434
1247189001181	rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566
1247189001182	RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; smart00967
1247189001183	SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588
1247189001184	Predicted HD superfamily hydrolase [General function prediction only]; Region: COG1418
1247189001185	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
1247189001186	Zn2+ binding site [ion binding]; other site
1247189001187	Mg2+ binding site [ion binding]; other site
1247189001188	Integral membrane protein, interacts with FtsH [General function prediction only]; Region: COG0670
1247189001189	Bacterial BAX inhibitor (BI)-1/YccA-like proteins; Region: BI-1-like_bacterial; cd10432
1247189001190	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3763
1247189001191	glutamate racemase; Provisional; Region: PRK00865
1247189001192	putative deoxyribonucleotide triphosphate pyrophosphatase/unknown domain fusion protein; Reviewed; Region: PRK02491
1247189001193	NTPase/HAM1.  This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515
1247189001194	active site
1247189001195	dimerization interface [polypeptide binding]; other site
1247189001196	Escherichia coli YfcE and related proteins, metallophosphatase domain; Region: MPP_YfcE; cd00841
1247189001197	active site
1247189001198	metal binding site [ion binding]; metal-binding site
1247189001199	homotetramer interface [polypeptide binding]; other site
1247189001200	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_30; cd04643
1247189001201	FOG: CBS domain [General function prediction only]; Region: COG0517
1247189001202	site-specific tyrosine recombinase XerD-like protein; Reviewed; Region: xerD; PRK02436
1247189001203	DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182
1247189001204	active site
1247189001205	catalytic residues [active]
1247189001206	DNA binding site [nucleotide binding]
1247189001207	Int/Topo IB signature motif; other site
1247189001208	segregation and condensation protein A; Reviewed; Region: scpA; PRK00104
1247189001209	segregation and condensation protein B; Reviewed; Region: scpB; PRK00135
1247189001210	16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187
1247189001211	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
1247189001212	RNA binding surface [nucleotide binding]; other site
1247189001213	Pseudouridine synthases, RsuA subfamily; Region: PseudoU_synth_RsuA_like; cd02870
1247189001214	active site
1247189001215	hypothetical protein; Validated; Region: PRK00041
1247189001216	Helix-turn-helix domain; Region: HTH_38; pfam13936
1247189001217	Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826
1247189001218	Integrase core domain; Region: rve; pfam00665
1247189001219	Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826
1247189001220	Helix-turn-helix domain; Region: HTH_38; pfam13936
1247189001221	Integrase core domain; Region: rve; pfam00665
1247189001222	Predicted rRNA methylase (SpoU class) [Translation, ribosomal structure and biogenesis]; Region: CspR; COG0219
1247189001223	Predicted membrane protein [Function unknown]; Region: COG3601
1247189001224	Protein of unknown function (DUF3816); Region: DUF3816; pfam12822
1247189001225	PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392
1247189001226	Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671
1247189001227	active site
1247189001228	Predicted Fe-S oxidoreductase [General function prediction only]; Region: COG1242
1247189001229	Putative rRNA methylase; Region: rRNA_methylase; pfam06962
1247189001230	Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253
1247189001231	Domain of unknown function DUF21; Region: DUF21; pfam01595
1247189001232	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590
1247189001233	Transporter associated domain; Region: CorC_HlyC; pfam03471
1247189001234	pyruvate formate-lyase 1-activating enzyme; Region: PFLA; TIGR02493
1247189001235	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
1247189001236	FeS/SAM binding site; other site
1247189001237	putative manganese-dependent inorganic pyrophosphatase; Provisional; Region: PRK05427
1247189001238	DHH family; Region: DHH; pfam01368
1247189001239	DHHA2 domain; Region: DHHA2; pfam02833
1247189001240	Domain of unknown function (DUF1803); Region: DUF1803; pfam08820
1247189001241	Domain of unknown function (DUF1803); Region: DUF1803; pfam08820
1247189001242	iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577
1247189001243	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
1247189001244	ABC-ATPase subunit  interface; other site
1247189001245	dimer interface [polypeptide binding]; other site
1247189001246	putative PBP binding regions; other site
1247189001247	iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577
1247189001248	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
1247189001249	ABC-ATPase subunit  interface; other site
1247189001250	dimer interface [polypeptide binding]; other site
1247189001251	putative PBP binding regions; other site
1247189001252	Periplasmic binding protein FeuA.  These proteins have predicted to function as initial receptors in ABC transport of metal ions in some eubacterial species.  They belong to the TroA superfamily of periplasmic metal binding proteins that share a distinct...; Region: FeuA; cd01138
1247189001253	Periplasmic binding protein; Region: Peripla_BP_2; pfam01497
1247189001254	putative ligand binding residues [chemical binding]; other site
1247189001255	ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120
1247189001256	ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214
1247189001257	Walker A/P-loop; other site
1247189001258	ATP binding site [chemical binding]; other site
1247189001259	Q-loop/lid; other site
1247189001260	ABC transporter signature motif; other site
1247189001261	Walker B; other site
1247189001262	D-loop; other site
1247189001263	H-loop/switch region; other site
1247189001264	UDP-N-acetylmuramoylalanyl-D-glutamate--L-lysine ligase; Provisional; Region: PRK14022
1247189001265	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
1247189001266	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
1247189001267	Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244
1247189001268	Stage V sporulation protein B, also known as Stage III sporulation protein F, and related proteins; Region: MATE_SpoVB_like; cd13124
1247189001269	Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826
1247189001270	Integrase core domain; Region: rve; pfam00665
1247189001271	Helix-turn-helix domain; Region: HTH_38; pfam13936
1247189001272	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
1247189001273	active site
1247189001274	Protease subunit of ATP-dependent Clp proteases [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: ClpP; COG0740
1247189001275	Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017
1247189001276	oligomer interface [polypeptide binding]; other site
1247189001277	active site residues [active]
1247189001278	Domain of unknown function (DUF4298); Region: DUF4298; pfam14131
1247189001279	Protein of unknown function (DUF964); Region: DUF964; cl01483
1247189001280	hypothetical protein; Provisional; Region: PRK02302
1247189001281	ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683
1247189001282	Type I periplasmic ligand-binding domain of uncharacterized ABC (Atpase Binding Cassette)-type active transport systems that are predicted to be involved in uptake of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_ligand_binding_like_12; cd06347
1247189001283	putative ligand binding site [chemical binding]; other site
1247189001284	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
1247189001285	Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582
1247189001286	TM-ABC transporter signature motif; other site
1247189001287	ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177
1247189001288	Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581
1247189001289	TM-ABC transporter signature motif; other site
1247189001290	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411
1247189001291	ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219
1247189001292	Walker A/P-loop; other site
1247189001293	ATP binding site [chemical binding]; other site
1247189001294	Q-loop/lid; other site
1247189001295	ABC transporter signature motif; other site
1247189001296	Walker B; other site
1247189001297	D-loop; other site
1247189001298	H-loop/switch region; other site
1247189001299	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410
1247189001300	ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224
1247189001301	Walker A/P-loop; other site
1247189001302	ATP binding site [chemical binding]; other site
1247189001303	Q-loop/lid; other site
1247189001304	ABC transporter signature motif; other site
1247189001305	Walker B; other site
1247189001306	D-loop; other site
1247189001307	H-loop/switch region; other site
1247189001308	FOG: CBS domain [General function prediction only]; Region: COG0517
1247189001309	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in  the acetoin utilization proteins in bacteria. Acetoin is a product of fermentative metabolism in many prokaryotic and eukaryotic microorganisms.  They produce...; Region: CBS_pair_ACT_assoc2; cd04585
1247189001310	FOG: CBS domain [General function prediction only]; Region: COG0517
1247189001311	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; pfam13808
1247189001312	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
1247189001313	Transposase [DNA replication, recombination, and repair]; Region: COG5433
1247189001314	thymidylate kinase; Validated; Region: tmk; PRK00698
1247189001315	Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672
1247189001316	TMP-binding site; other site
1247189001317	ATP-binding site [chemical binding]; other site
1247189001318	DNA polymerase III subunit delta'; Validated; Region: PRK07276
1247189001319	DNA polymerase III subunit delta'; Validated; Region: PRK07276
1247189001320	DNA polymerase III subunit delta'; Validated; Region: PRK08485
1247189001321	PSP1 C-terminal conserved region; Region: PSP1; cl00770
1247189001322	DNA replication intiation control protein YabA; Reviewed; Region: PRK13169
1247189001323	Predicted methyltransferases [General function prediction only]; Region: COG0313
1247189001324	Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648
1247189001325	putative SAM binding site [chemical binding]; other site
1247189001326	putative homodimer interface [polypeptide binding]; other site
1247189001327	CutC family; Region: CutC; pfam03932
1247189001328	3-phosphoserine/phosphohydroxythreonine aminotransferase; Provisional; Region: PRK05355
1247189001329	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
1247189001330	catalytic residue [active]
1247189001331	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
1247189001332	Coenzyme A binding pocket [chemical binding]; other site
1247189001333	Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350
1247189001334	The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445
1247189001335	DNA binding site [nucleotide binding]
1247189001336	active site
1247189001337	Arsenate Reductase (ArsC) family, unknown subfamily; uncharacterized proteins containing a CXXC motif with similarity to thioredoxin (TRX)-fold arsenic reductases, ArsC. Proteins containing a redox active CXXC motif like TRX and glutaredoxin (GRX)...; Region: ArsC_like; cd03036
1247189001338	ArsC family; Region: ArsC; pfam03960
1247189001339	putative ArsC-like catalytic residues; other site
1247189001340	putative TRX-like catalytic residues [active]
1247189001341	Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588
1247189001342	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
1247189001343	dimer interface [polypeptide binding]; other site
1247189001344	This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_16; cd07263
1247189001345	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
1247189001346	Transcriptional regulators [Transcription]; Region: PurR; COG1609
1247189001347	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
1247189001348	DNA binding site [nucleotide binding]
1247189001349	domain linker motif; other site
1247189001350	Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011
1247189001351	haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282
1247189001352	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cl17915
1247189001353	active site
1247189001354	motif I; other site
1247189001355	motif II; other site
1247189001356	haloacid dehalogenase-like hydrolase; Region: HAD; cl17202
1247189001357	Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490
1247189001358	putative metal binding site [ion binding]; other site
1247189001359	Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490
1247189001360	putative catalytic site [active]
1247189001361	putative metal binding site [ion binding]; other site
1247189001362	putative phosphate binding site [ion binding]; other site
1247189001363	Protein of unknown function (DUF1648); Region: DUF1648; pfam07853
1247189001364	SdpI/YhfL protein family; Region: SdpI; pfam13630
1247189001365	L-lactate permease [Energy production and conversion]; Region: LldP; COG1620
1247189001366	L-lactate permease; Region: Lactate_perm; cl00701
1247189001367	L-lactate oxidase; Region: L_lactate_ox; TIGR02708
1247189001368	L-Lactate oxidase (LOX) FMN-binding domain. LOX is a member of the family of FMN-containing alpha-hydroxyacid oxidases and catalyzes the oxidation of l-lactate using molecular oxygen to generate pyruvate and H2O2.  This family occurs in both prokaryotes...; Region: LOX_like_FMN; cd04737
1247189001369	teramer interface [polypeptide binding]; other site
1247189001370	active site
1247189001371	FMN binding site [chemical binding]; other site
1247189001372	catalytic residues [active]
1247189001373	Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459
1247189001374	Peptidase S8 family domain in Streptococcal C5a peptidases; Region: Peptidases_S8_C5a_Peptidase; cd07475
1247189001375	putative active site [active]
1247189001376	PA_C5a_like: Protease-associated domain containing proteins like Streptococcus pyogenes C5a peptidase. This group contains various PA domain-containing proteins similar to S. pyogenes C5a, including, i) Vpr, a minor extracellular serine protease from...; Region: PA_C5a_like; cd02133
1247189001377	putative integrin binding motif; other site
1247189001378	PA/protease domain interface [polypeptide binding]; other site
1247189001379	Peptidase S8 family domain in Streptococcal C5a peptidases; Region: Peptidases_S8_C5a_Peptidase; cd07475
1247189001380	Fn3-like domain (DUF1034); Region: DUF1034; pfam06280
1247189001381	C-terminal domain of CHU protein family; Region: CHU_C; cl17875
1247189001382	LPXTG-motif cell wall anchor domain; Region: LPXTG_anchor; TIGR01167
1247189001383	Predicted membrane protein [Function unknown]; Region: COG3619
1247189001384	methionyl-tRNA synthetase; Reviewed; Region: PRK12267
1247189001385	catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814
1247189001386	active site
1247189001387	HIGH motif; other site
1247189001388	KMSKS motif; other site
1247189001389	Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957
1247189001390	tRNA binding surface [nucleotide binding]; other site
1247189001391	anticodon binding site; other site
1247189001392	tRNA-binding-domain-containing Escherichia coli methionyl-tRNA synthetase (EcMetRS)-like proteins.  This family includes EcMetRS and Aquifex aeolicus Trbp111 (AaTrbp111). This domain has general tRNA binding properties.  MetRS aminoacylates methionine...; Region: tRNA_bind_EcMetRS_like; cd02800
1247189001393	dimer interface [polypeptide binding]; other site
1247189001394	putative tRNA-binding site [nucleotide binding]; other site
1247189001395	ribonucleotide-diphosphate reductase subunit beta; Provisional; Region: nrdF2; PRK13966
1247189001396	Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049
1247189001397	dimer interface [polypeptide binding]; other site
1247189001398	putative radical transfer pathway; other site
1247189001399	diiron center [ion binding]; other site
1247189001400	tyrosyl radical; other site
1247189001401	ribonucleotide reductase stimulatory protein; Reviewed; Region: nrdI; PRK03600
1247189001402	ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK07187
1247189001403	Ribonucleotide reductase N-terminal; Region: RNR_N; pfam08343
1247189001404	Class I ribonucleotide reductase; Region: RNR_I; cd01679
1247189001405	active site
1247189001406	dimer interface [polypeptide binding]; other site
1247189001407	catalytic residues [active]
1247189001408	effector binding site; other site
1247189001409	R2 peptide binding site; other site
1247189001410	Branched-chain amino acid transport protein; Region: Branch_AA_trans; cl00547
1247189001411	Branched-chain amino acid transport protein; Region: Branch_AA_trans; cl00547
1247189001412	Protein of unknown function (DUF2829); Region: DUF2829; pfam11195
1247189001413	3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK06550
1247189001414	classical (c) SDRs; Region: SDR_c; cd05233
1247189001415	NAD(P) binding site [chemical binding]; other site
1247189001416	active site
1247189001417	Protein of unknown function (DUF3977); Region: DUF3977; pfam13122
1247189001418	ASC-1 homology domain, subfamily similar to Enterococcus faecalis Ef3133. The ASCH domain, a small beta-barrel domain found in all three kingdoms of life, resembles the RNA-binding PUA domain and may also interact with RNA. ASCH has been proposed to...; Region: ASCH_Ef3133_like; cd06553
1247189001419	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
1247189001420	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
1247189001421	Sugar phosphate permease [Carbohydrate transport and metabolism]; Region: UhpC; COG2271
1247189001422	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1247189001423	putative substrate translocation pore; other site
1247189001424	bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase; Provisional; Region: glmU; PRK14354
1247189001425	N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540
1247189001426	Substrate binding site; other site
1247189001427	Mg++ binding site; other site
1247189001428	N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353
1247189001429	active site
1247189001430	substrate binding site [chemical binding]; other site
1247189001431	CoA binding site [chemical binding]; other site
1247189001432	ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424
1247189001433	dimer interface [polypeptide binding]; other site
1247189001434	ADP-ribose binding site [chemical binding]; other site
1247189001435	active site
1247189001436	nudix motif; other site
1247189001437	metal binding site [ion binding]; metal-binding site
1247189001438	5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Validated; Region: PRK05584
1247189001439	5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Region: MTA/SAH-Nsdase; TIGR01704
1247189001440	Mn-dependent transcriptional regulator [Transcription]; Region: TroR; COG1321
1247189001441	Iron dependent repressor, N-terminal DNA binding domain; Region: Fe_dep_repress; pfam01325
1247189001442	Iron dependent repressor, metal binding and dimerisation domain; Region: Fe_dep_repr_C; pfam02742
1247189001443	FeoA domain; Region: FeoA; pfam04023
1247189001444	ABC-type metal ion transport system, periplasmic component/surface adhesin [Inorganic ion transport and metabolism]; Region: LraI; COG0803
1247189001445	Metal binding protein PsaA.  These proteins have been shown to function as initial receptors in ABC transport of Mn2+ and as surface adhesins in some eubacterial species.  They belong to the TroA superfamily of periplasmic metal binding proteins that...; Region: PsaA; cd01137
1247189001446	metal binding site [ion binding]; metal-binding site
1247189001447	ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121
1247189001448	ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235
1247189001449	ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108
1247189001450	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
1247189001451	ABC-ATPase subunit  interface; other site
1247189001452	dimer interface [polypeptide binding]; other site
1247189001453	putative PBP binding regions; other site
1247189001454	Peptidyl-prolyl cis-trans isomerase (rotamase) - cyclophilin family [Posttranslational modification, protein turnover, chaperones]; Region: PpiB; COG0652
1247189001455	active site
1247189001456	Protein of unknown function (DUF1673); Region: DUF1673; pfam07895
1247189001457	DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674
1247189001458	FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580
1247189001459	Ftsk gamma domain; Region: Ftsk_gamma; pfam09397
1247189001460	50S ribosomal protein L11; Validated; Region: rplK; PRK00140
1247189001461	Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349
1247189001462	23S rRNA interface [nucleotide binding]; other site
1247189001463	L7/L12 interface [polypeptide binding]; other site
1247189001464	putative thiostrepton binding site; other site
1247189001465	L25 interface [polypeptide binding]; other site
1247189001466	Ribosomal protein L1.  The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA.  In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403
1247189001467	mRNA/rRNA interface [nucleotide binding]; other site
1247189001468	UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254
1247189001469	putative nucleotide binding site [chemical binding]; other site
1247189001470	uridine monophosphate binding site [chemical binding]; other site
1247189001471	homohexameric interface [polypeptide binding]; other site
1247189001472	ribosome recycling factor; Reviewed; Region: frr; PRK00083
1247189001473	Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation.  Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520
1247189001474	hinge region; other site
1247189001475	Predicted RNA-bindining protein (contains S1 and HTH domains) [General function prediction only]; Region: COG2996
1247189001476	S1 domain; Region: S1_2; pfam13509
1247189001477	methionine sulfoxide reductase A; Provisional; Region: PRK14054
1247189001478	hypothetical protein; Provisional; Region: PRK13672
1247189001479	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
1247189001480	Streptococcal 67 kDa myosin-cross-reactive antigen like family; Region: Strep_67kDa_ant; cl17487
1247189001481	Streptococcal 67 kDa myosin-cross-reactive antigen like family; Region: Strep_67kDa_ant; cl17487
1247189001482	Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702
1247189001483	PhoH-like protein; Region: PhoH; pfam02562
1247189001484	Uncharacterized subfamily of Uracil-DNA glycosylases; Region: UDG_like_1; cd10033
1247189001485	putative uracil binding site [chemical binding]; other site
1247189001486	putative active site [active]
1247189001487	metal-binding heat shock protein; Provisional; Region: PRK00016
1247189001488	Diacylglycerol kinase [Cell envelope biogenesis, outer membrane]; Region: DgkA; COG0818
1247189001489	GTPase Era; Reviewed; Region: era; PRK00089
1247189001490	E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163
1247189001491	G1 box; other site
1247189001492	GTP/Mg2+ binding site [chemical binding]; other site
1247189001493	Switch I region; other site
1247189001494	G2 box; other site
1247189001495	Switch II region; other site
1247189001496	G3 box; other site
1247189001497	G4 box; other site
1247189001498	G5 box; other site
1247189001499	KH domain; Region: KH_2; pfam07650
1247189001500	Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447
1247189001501	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1247189001502	Walker A/P-loop; other site
1247189001503	ATP binding site [chemical binding]; other site
1247189001504	Q-loop/lid; other site
1247189001505	ABC transporter signature motif; other site
1247189001506	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
1247189001507	Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various bacteriocins (mostly non-lantibiotic); Region: Peptidase_C39_like; cl00296
1247189001508	putative active site [active]
1247189001509	Bacteriocin class II with double-glycine leader peptide; Region: Bacteriocin_IIc; pfam10439
1247189001510	Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279
1247189001511	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1247189001512	active site
1247189001513	phosphorylation site [posttranslational modification]
1247189001514	intermolecular recognition site; other site
1247189001515	dimerization interface [polypeptide binding]; other site
1247189001516	LytTr DNA-binding domain; Region: LytTR; pfam04397
1247189001517	Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518
1247189001518	HlyD family secretion protein; Region: HlyD_3; pfam13437
1247189001519	bacteriocin secretion accessory protein; Region: bacteriocin_acc; TIGR01000
1247189001520	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
1247189001521	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1247189001522	ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122
1247189001523	Walker A/P-loop; other site
1247189001524	ATP binding site [chemical binding]; other site
1247189001525	Q-loop/lid; other site
1247189001526	ABC transporter signature motif; other site
1247189001527	Walker B; other site
1247189001528	D-loop; other site
1247189001529	H-loop/switch region; other site
1247189001530	Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various bacteriocins (mostly non-lantibiotic); Region: Peptidase_C39_like; cl00296
1247189001531	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
1247189001532	A sub-family of peptidase family C39. Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various...; Region: Peptidase_C39B; cd02418
1247189001533	putative active site [active]
1247189001534	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
1247189001535	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
1247189001536	non-specific DNA binding site [nucleotide binding]; other site
1247189001537	salt bridge; other site
1247189001538	sequence-specific DNA binding site [nucleotide binding]; other site
1247189001539	transcriptional activator, Rgg/GadR/MutR family, C-terminal domain; Region: RGG_Cterm; TIGR01716
1247189001540	formamidopyrimidine/5-formyluracil/ 5-hydroxymethyluracil DNA glycosylase; Validated; Region: PRK01103
1247189001541	N-terminal domain of Escherichia coli Fpg1/MutM and related bacterial DNA glycosylases; Region: EcFpg-like_N; cd08966
1247189001542	DNA binding site [nucleotide binding]
1247189001543	catalytic residue [active]
1247189001544	H2TH interface [polypeptide binding]; other site
1247189001545	putative catalytic residues [active]
1247189001546	turnover-facilitating residue; other site
1247189001547	intercalation triad [nucleotide binding]; other site
1247189001548	8OG recognition residue [nucleotide binding]; other site
1247189001549	putative reading head residues; other site
1247189001550	Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831
1247189001551	Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827
1247189001552	Dephospho-CoA kinase [Coenzyme metabolism]; Region: CoaE; COG0237
1247189001553	Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022
1247189001554	CoA-binding site [chemical binding]; other site
1247189001555	ATP-binding [chemical binding]; other site
1247189001556	ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121
1247189001557	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
1247189001558	Walker A/P-loop; other site
1247189001559	ATP binding site [chemical binding]; other site
1247189001560	Q-loop/lid; other site
1247189001561	ABC transporter signature motif; other site
1247189001562	Walker B; other site
1247189001563	D-loop; other site
1247189001564	H-loop/switch region; other site
1247189001565	Bacterial protein of unknown function (DUF853); Region: DUF853; pfam05872
1247189001566	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189
1247189001567	Walker A motif; other site
1247189001568	ATP binding site [chemical binding]; other site
1247189001569	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1247189001570	putative substrate translocation pore; other site
1247189001571	Major Facilitator Superfamily; Region: MFS_1; pfam07690
1247189001572	preprotein translocase subunit SecG; Reviewed; Region: secG; PRK06870
1247189001573	ribonuclease R; Region: RNase_R; TIGR02063
1247189001574	Ribonuclease B OB domain; Region: OB_RNB; pfam08206
1247189001575	RNB domain; Region: RNB; pfam00773
1247189001576	S1_RNase_R: RNase R C-terminal S1 domain. RNase R is a processive 3' to 5' exoribonuclease, which is a homolog of RNase II. RNase R degrades RNA with secondary structure having a 3' overhang of at least 7 nucleotides. RNase R and PNPase...; Region: S1_RNase_R; cd04471
1247189001577	RNA binding site [nucleotide binding]; other site
1247189001578	Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294
1247189001579	SmpB-tmRNA interface; other site
1247189001580	undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714
1247189001581	Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187
1247189001582	Ligand binding site; other site
1247189001583	Putative Catalytic site; other site
1247189001584	DXD motif; other site
1247189001585	DNA/RNA non-specific endonuclease; Region: Endonuclea_NS_2; cl17626
1247189001586	DNA/RNA non-specific endonuclease; Region: Endonuclease_NS; smart00892
1247189001587	Glyoxalase I catalyzes the isomerization of the hemithioacetal, formed by a 2-oxoaldehyde and glutathione, to S-D-lactoylglutathione; Region: Glyoxalase_I; cd07233
1247189001588	dimer interface [polypeptide binding]; other site
1247189001589	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
1247189001590	active site
1247189001591	metal binding site [ion binding]; metal-binding site
1247189001592	glutathione binding site [chemical binding]; other site
1247189001593	NAD(P)H:FMN oxidoreductase family. This domain catalyzes the reduction of flavin, nitrocompound, quinones and azo compounds using NADH or NADPH as an electron donor. The enzyme is a homodimer, and each monomer binds a FMN as co-factor. This family...; Region: NfsB_like_nitroreductase; cd02149
1247189001594	dimer interface [polypeptide binding]; other site
1247189001595	FMN binding site [chemical binding]; other site
1247189001596	Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006
1247189001597	Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321
1247189001598	Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092
1247189001599	active site
1247189001600	catabolite control protein A; Region: ccpA; TIGR01481
1247189001601	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
1247189001602	DNA binding site [nucleotide binding]
1247189001603	domain linker motif; other site
1247189001604	Ligand-binding domain of the catabolite control protein A (CcpA), which functions as the major transcriptional regulator of carbon catabolite repression/regulation; Region: PBP1_CcpA_like; cd06298
1247189001605	dimerization interface [polypeptide binding]; other site
1247189001606	effector binding site; other site
1247189001607	cytoplasmic alpha-amylase; Reviewed; Region: PRK09441
1247189001608	Alpha amylase catalytic domain found in bacterial and fungal Alpha amylases (also called 1,4-alpha-D-glucan-4-glucanohydrolase); Region: AmyAc_bac_fung_AmyA; cd11318
1247189001609	active site
1247189001610	Na/Ca binding site [ion binding]; other site
1247189001611	catalytic site [active]
1247189001612	Domain of unknown function (DUF1939); Region: DUF1939; pfam09154
1247189001613	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
1247189001614	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
1247189001615	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
1247189001616	This family is most closely related to the GT1 family of glycosyltransferases. UDP-glucose-diacylglycerol glucosyltransferase (UGDG; also known as 1,2-diacylglycerol 3-glucosyltransferase) catalyzes the transfer of glucose from UDP-glucose to 1; Region: GT1_UGDG_like; cd03817
1247189001617	putative ADP-binding pocket [chemical binding]; other site
1247189001618	threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK00413
1247189001619	TGS _ThrRS_N:  ThrRS (threonyl-tRNA Synthetase)  is a class II tRNA synthetase that couples threonine to its cognate tRNA.  In addition to its catalytic and anticodon-binding domains, ThrRS has an N-terminal TGS domain, named after the ThrRS, GTPase, and...; Region: TGS_ThrRS_N; cd01667
1247189001620	Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863
1247189001621	Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771
1247189001622	active site
1247189001623	dimer interface [polypeptide binding]; other site
1247189001624	motif 1; other site
1247189001625	motif 2; other site
1247189001626	motif 3; other site
1247189001627	ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860
1247189001628	anticodon binding site; other site
1247189001629	ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: COG4586
1247189001630	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1247189001631	Walker A/P-loop; other site
1247189001632	ATP binding site [chemical binding]; other site
1247189001633	Q-loop/lid; other site
1247189001634	ABC transporter signature motif; other site
1247189001635	Walker B; other site
1247189001636	D-loop; other site
1247189001637	H-loop/switch region; other site
1247189001638	ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4587
1247189001639	ABC-2 family transporter protein; Region: ABC2_membrane_6; cl01496
1247189001640	ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG3694
1247189001641	DhaKLM operon coactivator DhaQ; Provisional; Region: PRK14483
1247189001642	Dihydroxyacetone kinase [Carbohydrate transport and metabolism]; Region: DAK1; COG2376
1247189001643	probable dihydroxyacetone kinase regulator; Region: DHAK_reg; TIGR02366
1247189001644	dihydroxyacetone kinase subunit DhaK; Provisional; Region: PRK14481
1247189001645	Dihydroxyacetone kinase [Carbohydrate transport and metabolism]; Region: DAK1; COG2376
1247189001646	dihydroxyacetone kinase, phosphoprotein-dependent, L subunit; Region: dha_L_ycgS; TIGR02365
1247189001647	phosphotransferase mannnose-specific family component IIA; Provisional; Region: PRK14484
1247189001648	Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cd00333
1247189001649	amphipathic channel; other site
1247189001650	Asn-Pro-Ala signature motifs; other site
1247189001651	The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509
1247189001652	active site 2 [active]
1247189001653	active site 1 [active]
1247189001654	Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751
1247189001655	acetyl-CoA acetyltransferases; Region: AcCoA-C-Actrans; TIGR01930
1247189001656	dimer interface [polypeptide binding]; other site
1247189001657	active site
1247189001658	D-alanine--poly(phosphoribitol) ligase, subunit 1; Region: D-ala-DACP-lig; TIGR01734
1247189001659	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
1247189001660	AMP binding site [chemical binding]; other site
1247189001661	active site
1247189001662	acyl-activating enzyme (AAE) consensus motif; other site
1247189001663	CoA binding site [chemical binding]; other site
1247189001664	Protein of unknown function (DUF3114); Region: DUF3114; pfam11311
1247189001665	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1247189001666	dimer interface [polypeptide binding]; other site
1247189001667	conserved gate region; other site
1247189001668	putative PBP binding loops; other site
1247189001669	ABC-ATPase subunit interface; other site
1247189001670	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1247189001671	dimer interface [polypeptide binding]; other site
1247189001672	conserved gate region; other site
1247189001673	putative PBP binding loops; other site
1247189001674	ABC-ATPase subunit interface; other site
1247189001675	bifunctional adhesin/ABC transporter aspartate/glutamate-binding protein; Reviewed; Region: PRK11917
1247189001676	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
1247189001677	substrate binding pocket [chemical binding]; other site
1247189001678	membrane-bound complex binding site; other site
1247189001679	hinge residues; other site
1247189001680	ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262
1247189001681	ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126
1247189001682	Walker A/P-loop; other site
1247189001683	ATP binding site [chemical binding]; other site
1247189001684	Q-loop/lid; other site
1247189001685	ABC transporter signature motif; other site
1247189001686	Walker B; other site
1247189001687	D-loop; other site
1247189001688	H-loop/switch region; other site
1247189001689	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
1247189001690	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1247189001691	active site
1247189001692	phosphorylation site [posttranslational modification]
1247189001693	intermolecular recognition site; other site
1247189001694	dimerization interface [polypeptide binding]; other site
1247189001695	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
1247189001696	DNA binding site [nucleotide binding]
1247189001697	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: VicK; COG5002
1247189001698	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
1247189001699	putative active site [active]
1247189001700	heme pocket [chemical binding]; other site
1247189001701	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
1247189001702	dimer interface [polypeptide binding]; other site
1247189001703	phosphorylation site [posttranslational modification]
1247189001704	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1247189001705	ATP binding site [chemical binding]; other site
1247189001706	Mg2+ binding site [ion binding]; other site
1247189001707	G-X-G motif; other site
1247189001708	Metal-dependent hydrolases of the beta-lactamase superfamily I [General function prediction only]; Region: PhnP; COG1235
1247189001709	Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220
1247189001710	ribonuclease III; Reviewed; Region: rnc; PRK00102
1247189001711	RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593
1247189001712	dimerization interface [polypeptide binding]; other site
1247189001713	active site
1247189001714	metal binding site [ion binding]; metal-binding site
1247189001715	Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048
1247189001716	dsRNA binding site [nucleotide binding]; other site
1247189001717	ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278
1247189001718	AAA domain; Region: AAA_23; pfam13476
1247189001719	Walker A/P-loop; other site
1247189001720	ATP binding site [chemical binding]; other site
1247189001721	Q-loop/lid; other site
1247189001722	Chromosome segregation ATPases [Cell division and chromosome partitioning]; Region: Smc; COG1196
1247189001723	SMC proteins Flexible Hinge Domain; Region: SMC_hinge; smart00968
1247189001724	ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278
1247189001725	ABC transporter signature motif; other site
1247189001726	Walker B; other site
1247189001727	D-loop; other site
1247189001728	H-loop/switch region; other site
1247189001729	YSIRK type signal peptide; Region: YSIRK_signal; pfam04650
1247189001730	Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459
1247189001731	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
1247189001732	haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282
1247189001733	active site
1247189001734	motif I; other site
1247189001735	motif II; other site
1247189001736	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
1247189001737	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
1247189001738	haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282
1247189001739	active site
1247189001740	motif I; other site
1247189001741	motif II; other site
1247189001742	haloacid dehalogenase-like hydrolase; Region: HAD; cl17202
1247189001743	signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416
1247189001744	SRP54-type protein, helical bundle domain; Region: SRP54_N; pfam02881
1247189001745	The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115
1247189001746	P loop; other site
1247189001747	GTP binding site [chemical binding]; other site
1247189001748	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1247189001749	Major Facilitator Superfamily; Region: MFS_1; pfam07690
1247189001750	putative substrate translocation pore; other site
1247189001751	transcriptional antiterminator BglG; Provisional; Region: PRK09772
1247189001752	CAT RNA binding domain; Region: CAT_RBD; smart01061
1247189001753	PRD domain; Region: PRD; pfam00874
1247189001754	PRD domain; Region: PRD; pfam00874
1247189001755	PTS system, beta-glucoside-specific IIABC component; Region: PTS-II-ABC-beta; TIGR01995
1247189001756	PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212
1247189001757	active site turn [active]
1247189001758	phosphorylation site [posttranslational modification]
1247189001759	Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263
1247189001760	Phosphotransferase system IIA components [Carbohydrate transport and metabolism]; Region: NagE; COG2190
1247189001761	HPr interaction site; other site
1247189001762	glycerol kinase (GK) interaction site [polypeptide binding]; other site
1247189001763	active site
1247189001764	phosphorylation site [posttranslational modification]
1247189001765	Beta-glucosidase/6-phospho-beta-glucosidase/beta- galactosidase [Carbohydrate transport and metabolism]; Region: BglB; COG2723
1247189001766	beta-galactosidase; Region: BGL; TIGR03356
1247189001767	Predicted membrane protein [Function unknown]; Region: COG3689
1247189001768	Predicted permeases [General function prediction only]; Region: COG0701
1247189001769	Hydrolase of X-linked nucleoside diphosphate N terminal; Region: Nudix_N; pfam12535
1247189001770	Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_14; cd04672
1247189001771	nudix motif; other site
1247189001772	Uncharacterized conserved protein [Function unknown]; Region: COG3542
1247189001773	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
1247189001774	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1247189001775	active site
1247189001776	phosphorylation site [posttranslational modification]
1247189001777	intermolecular recognition site; other site
1247189001778	dimerization interface [polypeptide binding]; other site
1247189001779	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
1247189001780	DNA binding site [nucleotide binding]
1247189001781	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
1247189001782	dimer interface [polypeptide binding]; other site
1247189001783	phosphorylation site [posttranslational modification]
1247189001784	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1247189001785	ATP binding site [chemical binding]; other site
1247189001786	G-X-G motif; other site
1247189001787	PBP superfamily domain; Region: PBP_like_2; cl17296
1247189001788	ABC-type phosphate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: PstS; COG0226
1247189001789	ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstC; COG0573
1247189001790	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1247189001791	dimer interface [polypeptide binding]; other site
1247189001792	conserved gate region; other site
1247189001793	putative PBP binding loops; other site
1247189001794	ABC-ATPase subunit interface; other site
1247189001795	phosphate ABC transporter, permease protein PstA; Region: 3a0107s02c; TIGR00974
1247189001796	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1247189001797	dimer interface [polypeptide binding]; other site
1247189001798	conserved gate region; other site
1247189001799	putative PBP binding loops; other site
1247189001800	ABC-ATPase subunit interface; other site
1247189001801	phosphate transporter ATP-binding protein; Provisional; Region: PRK14240
1247189001802	ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260
1247189001803	Walker A/P-loop; other site
1247189001804	ATP binding site [chemical binding]; other site
1247189001805	Q-loop/lid; other site
1247189001806	ABC transporter signature motif; other site
1247189001807	Walker B; other site
1247189001808	D-loop; other site
1247189001809	H-loop/switch region; other site
1247189001810	phosphate transport system regulatory protein PhoU; Region: phoU_full; TIGR02135
1247189001811	PhoU domain; Region: PhoU; pfam01895
1247189001812	PhoU domain; Region: PhoU; pfam01895
1247189001813	Transposase; Region: HTH_Tnp_1; pfam01527
1247189001814	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963
1247189001815	Integrase core domain; Region: rve_3; pfam13683
1247189001816	Transcriptional accessory protein [Transcription]; Region: Tex; COG2183
1247189001817	Tex-like protein N-terminal domain; Region: Tex_N; pfam09371
1247189001818	Likely ribonuclease with RNase H fold; Region: YqgFc; smart00732
1247189001819	S1_Tex: The C-terminal S1 domain of a transcription accessory factor called Tex, which has been characterized in Bordetella pertussis and Pseudomonas aeruginosa. The tex gene is essential in Bortella pertusis and is named for its role in toxin expression; Region: S1_Tex; cd05685
1247189001820	RNA binding site [nucleotide binding]; other site
1247189001821	Putative stress-responsive transcriptional regulator [Transcription / Signal transduction mechanisms]; Region: PspC; COG1983
1247189001822	HPr kinase/phosphorylase; Provisional; Region: PRK05428
1247189001823	HPr Serine kinase N terminus; Region: Hpr_kinase_N; pfam02603
1247189001824	HprK/P, the bifunctional histidine-containing protein kinase/phosphatase, controls the phosphorylation state of the phosphocarrier protein HPr and regulates the utilization of carbon sources by gram-positive bacteria. It catalyzes both the ATP-dependent...; Region: HprK_C; cd01918
1247189001825	Hpr binding site; other site
1247189001826	active site
1247189001827	homohexamer subunit interaction site [polypeptide binding]; other site
1247189001828	prolipoprotein diacylglyceryl transferase; Reviewed; Region: PRK12437
1247189001829	Uncharacterized protein containing a divergent version of the methyl-accepting chemotaxis-like domain [General function prediction only]; Region: COG4768
1247189001830	YtxH-like protein; Region: YtxH; pfam12732
1247189001831	Protein of unknown function (DUF3270); Region: DUF3270; pfam11674
1247189001832	Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826
1247189001833	Integrase core domain; Region: rve; pfam00665
1247189001834	Helix-turn-helix domain; Region: HTH_38; pfam13936
1247189001835	Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826
1247189001836	Peptidase family U32; Region: Peptidase_U32; pfam01136
1247189001837	Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826
1247189001838	Peptidase family U32; Region: Peptidase_U32; pfam01136
1247189001839	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4443
1247189001840	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738
1247189001841	Ammonium Transporter Family; Region: Ammonium_transp; cl03012
1247189001842	lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484
1247189001843	LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322
1247189001844	dimer interface [polypeptide binding]; other site
1247189001845	putative anticodon binding site; other site
1247189001846	Lys_tRNA synthetase (LysRS) class II core domain. Class II LysRS is a dimer which attaches a lysine to the 3' OH group of ribose of the appropriate tRNA. Its assignment to class II aaRS is based upon its structure and the presence of three...; Region: LysRS_core; cd00775
1247189001847	motif 1; other site
1247189001848	active site
1247189001849	motif 2; other site
1247189001850	motif 3; other site
1247189001851	Predicted hydrolase (HAD superfamily) [General function prediction only]; Region: COG1011
1247189001852	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
1247189001853	motif II; other site
1247189001854	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
1247189001855	catalytic core [active]
1247189001856	hypothetical protein; Provisional; Region: PRK11770
1247189001857	Domain of unknown function (DUF307); Region: DUF307; pfam03733
1247189001858	Domain of unknown function (DUF307); Region: DUF307; pfam03733
1247189001859	This CD includes cysteinyl-tRNA(Pro) deacylases from Haemophilus influenzae and Escherichia coli and other related bacterial proteins. These trans-acting, single-domain proteins are homologs of ProX and also the cis-acting prolyl-tRNA synthetase (ProRS)...; Region: YbaK_deacylase; cd00002
1247189001860	putative deacylase active site [active]
1247189001861	Thiamine transporter protein (Thia_YuaJ); Region: Thia_YuaJ; cl17491
1247189001862	Thiamine transporter protein (Thia_YuaJ); Region: Thia_YuaJ; cl17491
1247189001863	PlyB is a bacteriophage endolysin that displays potent lytic activity toward Bacillus anthracis.  PlyB has an N-terminal glycosyl hydrolase family 25 (GH25) catalytic domain and a C-terminal bacterial SH3-like domain, SH3b.  Both domains are required for...; Region: GH25_PlyB-like; cd06523
1247189001864	Glycosyl hydrolases family 25; Region: Glyco_hydro_25; pfam01183
1247189001865	active site
1247189001866	Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per...; Region: GSH_Peroxidase; cd00340
1247189001867	catalytic residues [active]
1247189001868	dimer interface [polypeptide binding]; other site
1247189001869	oligoendopeptidase F; Region: pepF; TIGR00181
1247189001870	Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins); Region: GluZincin; cl14813
1247189001871	Zn binding site [ion binding]; other site
1247189001872	phosphoenolpyruvate carboxylase; Reviewed; Region: PRK00009
1247189001873	Phosphoenolpyruvate carboxylase [Energy production and conversion]; Region: Ppc; COG2352
1247189001874	Bacterial cell division membrane protein [Cell division and chromosome partitioning]; Region: FtsW; COG0772
1247189001875	RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937
1247189001876	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
1247189001877	DNA binding residues [nucleotide binding]
1247189001878	Sigma factor regulator N-terminal; Region: Sigma_reg_N; pfam13800
1247189001879	Sigma factor regulator C-terminal; Region: Sigma_reg_C; pfam13791
1247189001880	Sigma factor regulator C-terminal; Region: Sigma_reg_C; pfam13791
1247189001881	elongation factor Tu; Reviewed; Region: PRK00049
1247189001882	Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884
1247189001883	G1 box; other site
1247189001884	GEF interaction site [polypeptide binding]; other site
1247189001885	GTP/Mg2+ binding site [chemical binding]; other site
1247189001886	Switch I region; other site
1247189001887	G2 box; other site
1247189001888	G3 box; other site
1247189001889	Switch II region; other site
1247189001890	G4 box; other site
1247189001891	G5 box; other site
1247189001892	EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697
1247189001893	Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707
1247189001894	Antibiotic Binding Site [chemical binding]; other site
1247189001895	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
1247189001896	triosephosphate isomerase; Provisional; Region: PRK14567
1247189001897	Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311
1247189001898	substrate binding site [chemical binding]; other site
1247189001899	dimer interface [polypeptide binding]; other site
1247189001900	catalytic triad [active]
1247189001901	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963
1247189001902	Transposase; Region: HTH_Tnp_1; cl17663
1247189001903	putative transposase OrfB; Reviewed; Region: PHA02517
1247189001904	HTH-like domain; Region: HTH_21; pfam13276
1247189001905	Integrase core domain; Region: rve; pfam00665
1247189001906	Integrase core domain; Region: rve_2; pfam13333
1247189001907	L-lactate oxidase; Region: L_lactate_ox; TIGR02708
1247189001908	L-Lactate oxidase (LOX) FMN-binding domain. LOX is a member of the family of FMN-containing alpha-hydroxyacid oxidases and catalyzes the oxidation of l-lactate using molecular oxygen to generate pyruvate and H2O2.  This family occurs in both prokaryotes...; Region: LOX_like_FMN; cd04737
1247189001909	teramer interface [polypeptide binding]; other site
1247189001910	active site
1247189001911	FMN binding site [chemical binding]; other site
1247189001912	catalytic residues [active]
1247189001913	FemAB family; Region: FemAB; pfam02388
1247189001914	Acetyltransferase (GNAT) domain; Region: Acetyltransf_6; cl17497
1247189001915	FemAB family; Region: FemAB; pfam02388
1247189001916	Peptidoglycan interpeptide bridge formation enzyme [Cell wall/membrane/envelope biogenesis]; Region: COG2348
1247189001917	Acetyltransferase (GNAT) domain; Region: Acetyltransf_6; pfam13480
1247189001918	FemAB family; Region: FemAB; pfam02388
1247189001919	sugar phosphate phosphatase; Provisional; Region: PRK10513
1247189001920	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
1247189001921	motif II; other site
1247189001922	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
1247189001923	haloacid dehalogenase-like hydrolase; Region: HAD; cl17202
1247189001924	HD superfamily phosphohydrolases [General function prediction only]; Region: COG1078
1247189001925	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
1247189001926	Zn2+ binding site [ion binding]; other site
1247189001927	Mg2+ binding site [ion binding]; other site
1247189001928	Domain of unknown function (DUF1934); Region: DUF1934; pfam09148
1247189001929	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474
1247189001930	Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; pfam00690
1247189001931	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
1247189001932	Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246
1247189001933	haloacid dehalogenase-like hydrolase; Region: HAD; pfam12710
1247189001934	Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689
1247189001935	Transcriptional regulators [Transcription]; Region: PurR; COG1609
1247189001936	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
1247189001937	DNA binding site [nucleotide binding]
1247189001938	domain linker motif; other site
1247189001939	Ligand-binding domain of DNA transcription repressor RegR and other putative regulators such as KdgR and EndR; Region: PBP1_RegR_EndR_KdgR_like; cd06283
1247189001940	putative dimerization interface [polypeptide binding]; other site
1247189001941	putative ligand binding site [chemical binding]; other site
1247189001942	Heparinase II/III-like protein; Region: Hepar_II_III; pfam07940
1247189001943	Phosphotransferase system, mannose/fructose/N-acetylgalactosamine-specific component IID [Carbohydrate transport and metabolism]; Region: ManZ; COG3716
1247189001944	Phosphotransferase system, mannose/fructose/N-acetylgalactosamine-specific component IIC [Carbohydrate transport and metabolism]; Region: ManY; COG3715
1247189001945	PTS_IIB, PTS system, Mannose/sorbose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_man; cd00001
1247189001946	active site
1247189001947	phosphorylation site [posttranslational modification]
1247189001948	Glycosyl Hydrolase Family 88; Region: Glyco_hydro_88; pfam07470
1247189001949	Glycosyl Hydrolase Family 88; Region: Glyco_hydro_88; pfam07470
1247189001950	PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006
1247189001951	active pocket/dimerization site; other site
1247189001952	active site
1247189001953	phosphorylation site [posttranslational modification]
1247189001954	Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826
1247189001955	Integrase core domain; Region: rve; pfam00665
1247189001956	Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826
1247189001957	Helix-turn-helix domain; Region: HTH_38; pfam13936
1247189001958	short chain dehydrogenase; Provisional; Region: PRK08703
1247189001959	gluconate 5-dehydrogenase (Ga5DH)-like, classical (c) SDRs; Region: Ga5DH-like_SDR_c; cd05347
1247189001960	NADP binding site [chemical binding]; other site
1247189001961	homodimer interface [polypeptide binding]; other site
1247189001962	active site
1247189001963	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
1247189001964	hypothetical protein; Provisional; Region: PRK09273
1247189001965	Ribose 5-phosphate isomerase RpiB [Carbohydrate transport and metabolism]; Region: RpiB; COG0698
1247189001966	Ribose-5-phosphate isomerase; Region: DUF3666; pfam12408
1247189001967	Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524
1247189001968	2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166
1247189001969	substrate binding site [chemical binding]; other site
1247189001970	ATP binding site [chemical binding]; other site
1247189001971	2-keto-3-deoxy-6-phosphogluconate aldolase [Carbohydrate transport and metabolism]; Region: Eda; COG0800
1247189001972	KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452
1247189001973	active site
1247189001974	intersubunit interface [polypeptide binding]; other site
1247189001975	catalytic residue [active]
1247189001976	Glycosaminoglycan (GAG) polysaccharide lyase family. This family consists of a group of secreted bacterial lyase enzymes capable of acting on glycosaminoglycans, such as hyaluronan and chondroitin, in the extracellular matrix of host tissues; Region: GAG_Lyase; cd01083
1247189001977	substrate binding site [chemical binding]; other site
1247189001978	catalytic residues [active]
1247189001979	Glycosaminoglycan (GAG) polysaccharide lyase family. This family consists of a group of secreted bacterial lyase enzymes capable of acting on glycosaminoglycans, such as hyaluronan and chondroitin, in the extracellular matrix of host tissues; Region: GAG_Lyase; cl17706
1247189001980	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
1247189001981	metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cd00838
1247189001982	active site
1247189001983	metal binding site [ion binding]; metal-binding site
1247189001984	Tunnelling fold (T-fold). The five known T-folds are found in five different enzymes with different functions: dihydroneopterin-triphosphate epimerase (DHNTPE), dihydroneopterin aldolase (DHNA) , GTP cyclohydrolase I (GTPCH-1),  6-pyrovoyl...; Region: TFold; cl00263
1247189001985	HTH-like domain; Region: HTH_21; pfam13276
1247189001986	Integrase core domain; Region: rve; pfam00665
1247189001987	Integrase core domain; Region: rve_3; cl15866
1247189001988	Transposase; Region: HTH_Tnp_1; pfam01527
1247189001989	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963
1247189001990	Haloacid dehalogenase-like hydrolase; Region: HAD_2; pfam13419
1247189001991	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
1247189001992	motif II; other site
1247189001993	Firmicute fructose-1,6-bisphosphatase; Region: FBPase_2; pfam06874
1247189001994	Firmicute fructose-1,6-bisphosphatase; Region: FBPase_2; pfam06874
1247189001995	epoxyqueuosine reductase; Region: TIGR00276
1247189001996	Domain of unknown function (DUF1730); Region: DUF1730; pfam08331
1247189001997	PCRF domain; Region: PCRF; pfam03462
1247189001998	Protein chain release factor B [Translation, ribosomal structure and biogenesis]; Region: PrfB; COG1186
1247189001999	RF-1 domain; Region: RF-1; pfam00472
1247189002000	Predicted ATPase involved in cell division [Cell division and chromosome partitioning]; Region: FtsE; COG2884
1247189002001	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1247189002002	Walker A/P-loop; other site
1247189002003	ATP binding site [chemical binding]; other site
1247189002004	Q-loop/lid; other site
1247189002005	ABC transporter signature motif; other site
1247189002006	Walker B; other site
1247189002007	D-loop; other site
1247189002008	H-loop/switch region; other site
1247189002009	Cell division protein [Cell division and chromosome partitioning]; Region: FtsX; COG2177
1247189002010	cell division ABC transporter subunit FtsX; Provisional; Region: ftsX; PRK11026
1247189002011	FtsX-like permease family; Region: FtsX; pfam02687
1247189002012	Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491
1247189002013	bifunctional ATP-dependent DNA helicase/DNA polymerase III subunit epsilon; Validated; Region: PRK07246
1247189002014	DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127
1247189002015	active site
1247189002016	catalytic site [active]
1247189002017	substrate binding site [chemical binding]; other site
1247189002018	DEAD/DEAH box helicase; Region: DEAD; pfam00270
1247189002019	ATP binding site [chemical binding]; other site
1247189002020	Helicase C-terminal domain; Region: Helicase_C_2; pfam13307
1247189002021	aspartate aminotransferase; Provisional; Region: PRK05764
1247189002022	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
1247189002023	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1247189002024	homodimer interface [polypeptide binding]; other site
1247189002025	catalytic residue [active]
1247189002026	asparaginyl-tRNA synthetase; Validated; Region: asnC; PRK03932
1247189002027	AsnRS_cyto_like_N: N-terminal, anticodon recognition domain of the type found in human and Saccharomyces cerevisiae cytoplasmic asparaginyl-tRNA synthetase (AsnRS), in Brugia malayai AsnRs and, in various putative bacterial AsnRSs.  This domain is a...; Region: AsnRS_cyto_like_N; cd04323
1247189002028	putative dimer interface [polypeptide binding]; other site
1247189002029	putative anticodon binding site; other site
1247189002030	Asx tRNA synthetase (AspRS/AsnRS) class II core domain.  Assignment to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs in the core domain. This family includes AsnRS as well as...; Region: AsxRS_core; cd00776
1247189002031	homodimer interface [polypeptide binding]; other site
1247189002032	motif 1; other site
1247189002033	motif 2; other site
1247189002034	active site
1247189002035	motif 3; other site
1247189002036	Protein of unknown function (DUF1003); Region: DUF1003; pfam06210
1247189002037	glmZ(sRNA)-inactivating NTPase; Provisional; Region: PRK05416
1247189002038	conserved hypothetical protein, cofD-related; Region: CofD_related; TIGR01826
1247189002039	Family of CofD-like proteins and proteins related to YvcK; Region: CofD_YvcK; cd07044
1247189002040	dimer interface [polypeptide binding]; other site
1247189002041	phosphate binding site [ion binding]; other site
1247189002042	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1481
1247189002043	Sporulation Regulator WhiA N terminal; Region: WhiA_N; pfam10298
1247189002044	Peptidase family C69; Region: Peptidase_C69; pfam03577
1247189002045	ABC-type metal ion transport system, periplasmic component/surface adhesin [Inorganic ion transport and metabolism]; Region: LraI; COG0803
1247189002046	Metal binding protein AcdA.  These proteins have been shown to function in the ABC uptake of Zn2+ and Mn2+ and in competence for genetic transformation and adhesion. The AcdA proteins belong to the TroA superfamily of helical backbone metal receptor...; Region: AdcA; cd01017
1247189002047	metal binding site [ion binding]; metal-binding site
1247189002048	YodA lipocalin-like domain; Region: YodA; pfam09223
1247189002049	Transcriptional regulators [Transcription]; Region: PhnF; COG2188
1247189002050	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
1247189002051	DNA-binding site [nucleotide binding]; DNA binding site
1247189002052	UTRA domain; Region: UTRA; pfam07702
1247189002053	putative sugar isomerase, AgaS family; Region: agaS_fam; TIGR02815
1247189002054	SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008
1247189002055	dimer interface [polypeptide binding]; other site
1247189002056	active site
1247189002057	AgaS-like protein. AgaS contains a SIS (Sugar ISomerase) domain which is found in many phosphosugar isomerases and phosphosugar binding proteins. AgaS is a putative isomerase in Escherichia coli. It is similar to the glucosamine-6-phosphate synthases; Region: SIS_AgaS_like; cd05010
1247189002058	putative active site [active]
1247189002059	tagatose 1,6-diphosphate aldolase; Reviewed; Region: PRK12399
1247189002060	Transcriptional regulators [Transcription]; Region: PhnF; COG2188
1247189002061	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
1247189002062	DNA-binding site [nucleotide binding]; DNA binding site
1247189002063	The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; Region: UTRA; smart00866
1247189002064	Beta-galactosidase [Carbohydrate transport and metabolism]; Region: LacA; COG1874
1247189002065	Glycosyl hydrolases family 35; Region: Glyco_hydro_35; pfam01301
1247189002066	PTS_IIB, PTS system, Mannose/sorbose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_man; cd00001
1247189002067	active site
1247189002068	phosphorylation site [posttranslational modification]
1247189002069	Phosphotransferase system, mannose/fructose/N-acetylgalactosamine-specific component IIC [Carbohydrate transport and metabolism]; Region: ManY; COG3715
1247189002070	PTS system mannose/fructose/sorbose family IID component; Region: EIID-AGA; pfam03613
1247189002071	PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006
1247189002072	active pocket/dimerization site; other site
1247189002073	active site
1247189002074	phosphorylation site [posttranslational modification]
1247189002075	50S ribosomal protein L31 type B; Reviewed; Region: rpmE2; PRK01678
1247189002076	Helix-turn-helix domain; Region: HTH_38; pfam13936
1247189002077	Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826
1247189002078	Integrase core domain; Region: rve; pfam00665
1247189002079	Exopolyphosphatase-related proteins [General function prediction only]; Region: COG0618
1247189002080	DHH family; Region: DHH; pfam01368
1247189002081	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
1247189002082	putative S-transferase; Provisional; Region: PRK11752
1247189002083	GST_N family, Ure2p-like subfamily; composed of the Saccharomyces cerevisiae Ure2p and related GSTs. Ure2p is a regulator for nitrogen catabolism in yeast. It represses the expression of several gene products involved in the use of poor nitrogen sources...; Region: GST_N_Ure2p_like; cd03048
1247189002084	C-terminal domain interface [polypeptide binding]; other site
1247189002085	GSH binding site (G-site) [chemical binding]; other site
1247189002086	dimer interface [polypeptide binding]; other site
1247189002087	C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cl02776
1247189002088	N-terminal domain interface [polypeptide binding]; other site
1247189002089	dimer interface [polypeptide binding]; other site
1247189002090	substrate binding pocket (H-site) [chemical binding]; other site
1247189002091	Adenosine deaminase [Nucleotide transport and metabolism]; Region: Add; COG1816
1247189002092	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
1247189002093	active site
1247189002094	flavodoxin; Validated; Region: PRK07308
1247189002095	hypothetical protein; Provisional; Region: PRK07248
1247189002096	Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038
1247189002097	CLC voltage-gated chloride channel. The ClC chloride channels catalyse the selective flow of Cl- ions across cell membranes, thereby regulating electrical excitation in skeletal muscle and the flow of salt and water across epithelial barriers. This...; Region: Voltage_gated_ClC; cl02915
1247189002098	Cl- selectivity filter; other site
1247189002099	Cl- binding residues [ion binding]; other site
1247189002100	pore gating glutamate residue; other site
1247189002101	dimer interface [polypeptide binding]; other site
1247189002102	50S ribosomal protein L19; Provisional; Region: rplS; PRK05338
1247189002103	Cell cycle protein; Region: FTSW_RODA_SPOVE; cl00511
1247189002104	Bacterial cell division membrane protein [Cell division and chromosome partitioning]; Region: FtsW; COG0772
1247189002105	haloacid dehalogenase superfamily, subfamily IA, variant 1 with third motif having Dx(3-4)D or Dx(3-4)E; Region: HAD-SF-IA-v1; TIGR01549
1247189002106	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
1247189002107	motif II; other site
1247189002108	DNA gyrase subunit B; Validated; Region: gyrB; PRK05644
1247189002109	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1247189002110	Mg2+ binding site [ion binding]; other site
1247189002111	G-X-G motif; other site
1247189002112	TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822
1247189002113	anchoring element; other site
1247189002114	dimer interface [polypeptide binding]; other site
1247189002115	ATP binding site [chemical binding]; other site
1247189002116	TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366
1247189002117	active site
1247189002118	putative metal-binding site [ion binding]; other site
1247189002119	DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986
1247189002120	septation ring formation regulator EzrA; Provisional; Region: PRK04778
1247189002121	Phosphoserine phosphatase [Amino acid transport and metabolism]; Region: SerB; COG0560
1247189002122	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
1247189002123	motif II; other site
1247189002124	Protein of unknown function (DUF1694); Region: DUF1694; cl02318
1247189002125	enolase; Provisional; Region: eno; PRK00077
1247189002126	Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313
1247189002127	dimer interface [polypeptide binding]; other site
1247189002128	metal binding site [ion binding]; metal-binding site
1247189002129	substrate binding pocket [chemical binding]; other site
1247189002130	bacteriocin protoxin, streptolysin S family; Region: streptolysinS; TIGR03602
1247189002131	This family is the oxydase domain of NRPS (non-ribosomal peptide synthetase) and other proteins that modify polypeptides by cyclizing a thioester to form a ring. These include epoB, part of the epothilone biosynthesis pathway; tubD, part of the tubulysin...; Region: mcbC-like_oxidoreductase; cd02142
1247189002132	putative FMN binding site [chemical binding]; other site
1247189002133	NADPH bind site [chemical binding]; other site
1247189002134	thiazole/oxazole-forming peptide maturase, SagC family component; Region: cyclo_dehy_ocin; TIGR03603
1247189002135	thiazole/oxazole-forming peptide maturase, SagD family component; Region: TOMM_cyclo_SagD; TIGR03604
1247189002136	YcaO-like family; Region: YcaO; pfam02624
1247189002137	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
1247189002138	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1247189002139	Walker A/P-loop; other site
1247189002140	ATP binding site [chemical binding]; other site
1247189002141	Q-loop/lid; other site
1247189002142	ABC transporter signature motif; other site
1247189002143	Walker B; other site
1247189002144	D-loop; other site
1247189002145	H-loop/switch region; other site
1247189002146	ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698
1247189002147	ABC-2 type transporter; Region: ABC2_membrane; pfam01061
1247189002148	ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842
1247189002149	ABC-2 type transporter; Region: ABC2_membrane; pfam01061
1247189002150	Predicted extracellular nuclease [General function prediction only]; Region: COG2374
1247189002151	YhcR_OBF_like: A subfamily of OB-fold domains similar to the OB folds of Bacillus subtilis YhcR. YhcR is a sugar-nonspecific nuclease, which is active in the presence of Ca2+ and Mn2+. It cleaves RNA endonucleolytically, producing 3'-monophosphate...; Region: YhcR_OBF_like; cd04486
1247189002152	generic binding surface II; other site
1247189002153	generic binding surface I; other site
1247189002154	YhcR_OBF_like: A subfamily of OB-fold domains similar to the OB folds of Bacillus subtilis YhcR. YhcR is a sugar-nonspecific nuclease, which is active in the presence of Ca2+ and Mn2+. It cleaves RNA endonucleolytically, producing 3'-monophosphate...; Region: YhcR_OBF_like; cd04486
1247189002155	generic binding surface II; other site
1247189002156	generic binding surface I; other site
1247189002157	Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490
1247189002158	putative catalytic site [active]
1247189002159	putative metal binding site [ion binding]; other site
1247189002160	putative phosphate binding site [ion binding]; other site
1247189002161	Gram positive anchor; Region: Gram_pos_anchor; pfam00746
1247189002162	Predicted membrane protein [Function unknown]; Region: COG4708
1247189002163	NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956
1247189002164	NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114
1247189002165	nucleotide binding pocket [chemical binding]; other site
1247189002166	K-X-D-G motif; other site
1247189002167	catalytic site [active]
1247189002168	NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120
1247189002169	NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119
1247189002170	Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027
1247189002171	Dimer interface [polypeptide binding]; other site
1247189002172	BRCT sequence motif; other site
1247189002173	putative lipid kinase; Reviewed; Region: PRK13055
1247189002174	Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781
1247189002175	Family 41 Carbohydrate-Binding Module from pullulanase-like enzymes; Region: CBM41_pullulanase; cd10315
1247189002176	carbohydrate binding site [chemical binding]; other site
1247189002177	pullulanase, type I; Region: pulA_typeI; TIGR02104
1247189002178	Early set domain associated with the catalytic domain of pullulanase (also called dextrinase and alpha-dextrin endo-1,6-alpha glucosidase); Region: E_set_Pullulanase; cd02860
1247189002179	Alpha amylase catalytic domain found in Pullulanase (also called dextrinase; alpha-dextrin endo-1,6-alpha glucosidase), limit dextrinase, and related proteins; Region: AmyAc_Pullulanase_LD-like; cd11341
1247189002180	Ca binding site [ion binding]; other site
1247189002181	active site
1247189002182	catalytic site [active]
1247189002183	glycogen branching enzyme; Provisional; Region: PRK12313
1247189002184	N-terminal Early set domain associated with the catalytic domain of prokaryotic glycogen branching enzyme; Region: E_set_GBE_prok_N; cd02855
1247189002185	Alpha amylase catalytic domain found in the Glycogen branching enzyme (also called 1,4-alpha-glucan branching enzyme); Region: AmyAc_Glg_BE; cd11322
1247189002186	active site
1247189002187	catalytic site [active]
1247189002188	Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; pfam02806
1247189002189	glucose-1-phosphate adenylyltransferase; Region: glgC; TIGR02091
1247189002190	ADP-glucose pyrophosphorylase is involved in the biosynthesis of glycogen or starch; Region: ADP_Glucose_PP; cd02508
1247189002191	ligand binding site; other site
1247189002192	oligomer interface; other site
1247189002193	Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651
1247189002194	dimer interface [polypeptide binding]; other site
1247189002195	N-terminal domain interface [polypeptide binding]; other site
1247189002196	glucose-1-phosphate adenylyltransferase, GlgD subunit; Region: glgD; TIGR02092
1247189002197	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
1247189002198	active site
1247189002199	Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651
1247189002200	dimer interface [polypeptide binding]; other site
1247189002201	N-terminal domain interface [polypeptide binding]; other site
1247189002202	sulfate 1 binding site; other site
1247189002203	This family is most closely related to the GT1 family of glycosyltransferases. Glycogen synthase catalyzes the formation and elongation of the alpha-1,4-glucose backbone using ADP-glucose, the second and key step of glycogen biosynthesis. This family...; Region: GT1_Glycogen_synthase_DULL1_like; cd03791
1247189002204	glycogen synthase; Provisional; Region: glgA; PRK00654
1247189002205	ADP-binding pocket [chemical binding]; other site
1247189002206	homodimer interface [polypeptide binding]; other site
1247189002207	F0F1 ATP synthase subunit C; Provisional; Region: PRK13467
1247189002208	F0F1-type ATP synthase, subunit a [Energy production and conversion]; Region: AtpB; COG0356
1247189002209	F0F1 ATP synthase subunit A; Validated; Region: PRK05815
1247189002210	F0F1-type ATP synthase, subunit b [Energy production and conversion]; Region: AtpF; COG0711
1247189002211	F0F1 ATP synthase subunit B; Validated; Region: PRK05759
1247189002212	F0F1 ATP synthase subunit delta; Validated; Region: PRK05758
1247189002213	ATP synthase delta (OSCP) subunit; Region: OSCP; pfam00213
1247189002214	F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281
1247189002215	ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874
1247189002216	F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132
1247189002217	beta subunit interaction interface [polypeptide binding]; other site
1247189002218	Walker A motif; other site
1247189002219	ATP binding site [chemical binding]; other site
1247189002220	Walker B motif; other site
1247189002221	ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306
1247189002222	mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151
1247189002223	core domain interface [polypeptide binding]; other site
1247189002224	epsilon subunit interface [polypeptide binding]; other site
1247189002225	F0F1 ATP synthase subunit beta; Validated; Region: PRK09280
1247189002226	ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874
1247189002227	F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133
1247189002228	alpha subunit interaction interface [polypeptide binding]; other site
1247189002229	Walker A motif; other site
1247189002230	ATP binding site [chemical binding]; other site
1247189002231	Walker B motif; other site
1247189002232	inhibitor binding site; inhibition site
1247189002233	ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306
1247189002234	ATP synthase CF1 epsilon subunit; Region: atpE; CHL00063
1247189002235	mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152
1247189002236	gamma subunit interface [polypeptide binding]; other site
1247189002237	epsilon subunit interface [polypeptide binding]; other site
1247189002238	LBP interface [polypeptide binding]; other site
1247189002239	Protein of unknown function (DUF1146); Region: DUF1146; cl11486
1247189002240	UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072
1247189002241	UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555
1247189002242	hinge; other site
1247189002243	active site
1247189002244	DNA-directed RNA polymerase subunit beta; Region: EpuA; pfam11772
1247189002245	DNA/RNA non-specific endonuclease; Region: Endonuclease_NS; smart00892
1247189002246	DNA/RNA non-specific endonuclease; Region: Endonuclea_NS_2; cl17626
1247189002247	phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488
1247189002248	Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912
1247189002249	Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496
1247189002250	dimer interface [polypeptide binding]; other site
1247189002251	motif 1; other site
1247189002252	active site
1247189002253	motif 2; other site
1247189002254	motif 3; other site
1247189002255	phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629
1247189002256	tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain.  PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796
1247189002257	putative tRNA-binding site [nucleotide binding]; other site
1247189002258	B3/4 domain; Region: B3_4; pfam03483
1247189002259	tRNA synthetase B5 domain; Region: B5; smart00874
1247189002260	Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA,  PheRS is an...; Region: PheRS_beta_core; cd00769
1247189002261	dimer interface [polypeptide binding]; other site
1247189002262	motif 1; other site
1247189002263	motif 3; other site
1247189002264	motif 2; other site
1247189002265	Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; smart00896
1247189002266	OsmC-like protein; Region: OsmC; cl00767
1247189002267	Protein of unknown function (DUF1722); Region: DUF1722; cl01284
1247189002268	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
1247189002269	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
1247189002270	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
1247189002271	Walker A/P-loop; other site
1247189002272	ATP binding site [chemical binding]; other site
1247189002273	Q-loop/lid; other site
1247189002274	ABC transporter signature motif; other site
1247189002275	Walker B; other site
1247189002276	D-loop; other site
1247189002277	H-loop/switch region; other site
1247189002278	Predicted metalloprotease [General function prediction only]; Region: COG2321
1247189002279	Putative neutral zinc metallopeptidase; Region: Zn_peptidase; pfam04228
1247189002280	ATP-dependent nuclease subunit B; Region: rexB_recomb; TIGR02774
1247189002281	PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705
1247189002282	helicase-exonuclease AddAB, AddA subunit, Firmicutes type; Region: addA_Gpos; TIGR02785
1247189002283	Part of AAA domain; Region: AAA_19; pfam13245
1247189002284	Family description; Region: UvrD_C_2; pfam13538
1247189002285	PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705
1247189002286	transaminase; Validated; Region: PRK07324
1247189002287	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
1247189002288	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1247189002289	homodimer interface [polypeptide binding]; other site
1247189002290	catalytic residue [active]
1247189002291	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
1247189002292	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
1247189002293	substrate binding pocket [chemical binding]; other site
1247189002294	membrane-bound complex binding site; other site
1247189002295	hinge residues; other site
1247189002296	sic protein; Region: SIC; pfam03482
1247189002297	30S ribosomal protein S21; Reviewed; Region: rpsU; PRK00270
1247189002298	Large-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscL; COG1970
1247189002299	large-conductance mechanosensitive channel; Reviewed; Region: mscL; PRK00567
1247189002300	DNA primase; Validated; Region: dnaG; PRK05667
1247189002301	CHC2 zinc finger; Region: zf-CHC2; pfam01807
1247189002302	DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275
1247189002303	TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364
1247189002304	active site
1247189002305	metal binding site [ion binding]; metal-binding site
1247189002306	interdomain interaction site; other site
1247189002307	DnaB-helicase binding domain of primase; Region: DnaB_bind; pfam10410
1247189002308	RNA polymerase sigma factor RpoD; Validated; Region: PRK09210
1247189002309	Sigma-70 factor, region 1.1; Region: Sigma70_r1_1; pfam03979
1247189002310	Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140
1247189002311	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
1247189002312	Sigma-70 region 3; Region: Sigma70_r3; pfam04539
1247189002313	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
1247189002314	DNA binding residues [nucleotide binding]
1247189002315	Predicted metal-sulfur cluster biosynthetic enzyme [General function prediction only]; Region: PaaD; COG2151
1247189002316	dTDP-6-deoxy-L-lyxo-4-hexulose reductase and related proteins, extended (e) SDRs; Region: dTDP_HR_like_SDR_e; cd05254
1247189002317	RmlD substrate binding domain; Region: RmlD_sub_bind; pfam04321
1247189002318	NADP binding site [chemical binding]; other site
1247189002319	active site
1247189002320	putative substrate binding site [chemical binding]; other site
1247189002321	This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_6; cd04955
1247189002322	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
1247189002323	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
1247189002324	Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_d; cd04196
1247189002325	Probable Catalytic site; other site
1247189002326	ABC-type polysaccharide/polyol phosphate export systems, permease component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagG; COG1682
1247189002327	ABC-2 type transporter; Region: ABC2_membrane; pfam01061
1247189002328	ABC-type polysaccharide/polyol phosphate transport system, ATPase component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagH; COG1134
1247189002329	ATP-binding cassette component of polysaccharide transport system; Region: ABC_KpsT_Wzt; cd03220
1247189002330	Walker A/P-loop; other site
1247189002331	ATP binding site [chemical binding]; other site
1247189002332	Q-loop/lid; other site
1247189002333	ABC transporter signature motif; other site
1247189002334	Walker B; other site
1247189002335	D-loop; other site
1247189002336	H-loop/switch region; other site
1247189002337	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
1247189002338	Glycosyl transferase family 2; Region: Glycos_transf_2; pfam00535
1247189002339	active site
1247189002340	Rhamnan synthesis protein F; Region: RgpF; pfam05045
1247189002341	Lipopolysaccharide biosynthesis protein [Cell envelope biogenesis, outer membrane]; Region: RgpF; COG3754
1247189002342	dolichyl-phosphate beta-D-mannosyltransferase; Region: PLN02726
1247189002343	DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179
1247189002344	Ligand binding site; other site
1247189002345	Putative Catalytic site; other site
1247189002346	DXD motif; other site
1247189002347	Predicted membrane protein [Function unknown]; Region: COG4713
1247189002348	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
1247189002349	Glycosyltransferase Family 4; Region: Glyco_transf_4; pfam13439
1247189002350	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
1247189002351	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
1247189002352	Sulfatase; Region: Sulfatase; pfam00884
1247189002353	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
1247189002354	UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247
1247189002355	homodimer interface [polypeptide binding]; other site
1247189002356	active site
1247189002357	substrate binding site [chemical binding]; other site
1247189002358	Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244
1247189002359	Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326
1247189002360	peptidase T; Region: peptidase-T; TIGR01882
1247189002361	M20 Peptidase T specifically cleaves tripeptides; Region: M20_peptT; cd03892
1247189002362	metal binding site [ion binding]; metal-binding site
1247189002363	dimer interface [polypeptide binding]; other site
1247189002364	Ferredoxin [Energy production and conversion]; Region: Fer; COG1141
1247189002365	cytidylate kinase; Provisional; Region: cmk; PRK00023
1247189002366	Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020
1247189002367	CMP-binding site; other site
1247189002368	The sites determining sugar specificity; other site
1247189002369	translation initiation factor IF-3; Reviewed; Region: infC; PRK00028
1247189002370	Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198
1247189002371	Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707
1247189002372	50S ribosomal protein L35; Reviewed; Region: rpmI; PRK00172
1247189002373	Ribosomal protein L20; Region: Ribosomal_L20; cd07026
1247189002374	23S rRNA binding site [nucleotide binding]; other site
1247189002375	L21 binding site [polypeptide binding]; other site
1247189002376	L13 binding site [polypeptide binding]; other site
1247189002377	Phosphoglycerol transferase and related proteins, alkaline phosphatase superfamily [Cell envelope biogenesis, outer membrane]; Region: MdoB; COG1368
1247189002378	Sulfatase; Region: Sulfatase; pfam00884
1247189002379	Predicted SAM-dependent methyltransferases [General function prediction only]; Region: COG1092
1247189002380	Middle domain of the SAM-dependent methyltransferase RlmI and related proteins; Region: RlmI_M_like; cd11572
1247189002381	putative RNA binding site [nucleotide binding]; other site
1247189002382	Methyltransferase domain; Region: Methyltransf_26; pfam13659
1247189002383	3-dehydroquinate dehydratase [Amino acid transport and metabolism]; Region: AroD; COG0710
1247189002384	Type I 3-dehydroquinase, (3-dehydroquinate dehydratase or DHQase); Region: DHQase_I; cd00502
1247189002385	active site
1247189002386	catalytic residue [active]
1247189002387	dimer interface [polypeptide binding]; other site
1247189002388	Chorismate synthase [Amino acid transport and metabolism]; Region: AroC; COG0082
1247189002389	Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304
1247189002390	Tetramer interface [polypeptide binding]; other site
1247189002391	active site
1247189002392	FMN-binding site [chemical binding]; other site
1247189002393	hypothetical protein; Provisional; Region: PRK13676
1247189002394	glutathione reductase; Validated; Region: PRK06116
1247189002395	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
1247189002396	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
1247189002397	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
1247189002398	folylpolyglutamate synthase/dihydrofolate synthase; Region: folC; TIGR01499
1247189002399	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
1247189002400	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; pfam13808
1247189002401	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
1247189002402	Transposase [DNA replication, recombination, and repair]; Region: COG5433
1247189002403	Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104
1247189002404	cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402
1247189002405	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
1247189002406	catalytic residue [active]
1247189002407	thiamine biosynthesis protein ThiI; Provisional; Region: PRK01565
1247189002408	THUMP domain of thiamine biosynthesis protein ThiI; Region: THUMP_ThiI; cd11716
1247189002409	ThiI is required for thiazole synthesis in the thiamine biosynthesis pathway. It belongs to the Adenosine Nucleotide Hydrolysis suoerfamily and predicted to bind to Adenosine nucleotide; Region: ThiI; cd01712
1247189002410	Ligand Binding Site [chemical binding]; other site
1247189002411	Bacterial capsule synthesis protein PGA_cap; Region: PGA_cap; smart00854
1247189002412	CapA and related proteins, metallophosphatase domain; Region: MPP_CapA; cd07381
1247189002413	putative active site [active]
1247189002414	putative metal binding site [ion binding]; other site
1247189002415	Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826
1247189002416	Helix-turn-helix domain; Region: HTH_38; pfam13936
1247189002417	Integrase core domain; Region: rve; pfam00665
1247189002418	Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826
1247189002419	Helix-turn-helix domain; Region: HTH_38; pfam13936
1247189002420	Integrase core domain; Region: rve; pfam00665
1247189002421	Transcriptional regulator [Transcription]; Region: LysR; COG0583
1247189002422	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1247189002423	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
1247189002424	dimerization interface [polypeptide binding]; other site
1247189002425	lipoprotein signal peptidase; Provisional; Region: PRK14797
1247189002426	lipoprotein signal peptidase; Provisional; Region: PRK14787
1247189002427	Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564
1247189002428	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
1247189002429	RNA binding surface [nucleotide binding]; other site
1247189002430	Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869
1247189002431	active site
1247189002432	Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869
1247189002433	Uncharacterized conserved protein [Function unknown]; Region: COG0398
1247189002434	SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335
1247189002435	Pyrimidine operon attenuation protein/uracil phosphoribosyltransferase [Nucleotide transport and metabolism]; Region: PyrR; COG2065
1247189002436	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
1247189002437	active site
1247189002438	uracil transporter; Provisional; Region: PRK10720
1247189002439	aspartate carbamoyltransferase catalytic subunit; Provisional; Region: pyrB; PRK00856
1247189002440	Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729
1247189002441	Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185
1247189002442	carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564
1247189002443	Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; smart01097
1247189002444	Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744
1247189002445	catalytic site [active]
1247189002446	subunit interface [polypeptide binding]; other site
1247189002447	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
1247189002448	Carbamoylphosphate synthase large subunit (split gene in MJ) [Amino acid transport and metabolism / Nucleotide transport and metabolism]; Region: CarB; COG0458
1247189002449	Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786
1247189002450	Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787
1247189002451	Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787
1247189002452	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
1247189002453	Carbamoylphosphate synthase large subunit (split gene in MJ) [Amino acid transport and metabolism / Nucleotide transport and metabolism]; Region: CarB; COG0458
1247189002454	ATP-grasp domain; Region: ATP-grasp_4; cl17255
1247189002455	Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424
1247189002456	IMP binding site; other site
1247189002457	dimer interface [polypeptide binding]; other site
1247189002458	interdomain contacts; other site
1247189002459	partial ornithine binding site; other site
1247189002460	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
1247189002461	HlyD family secretion protein; Region: HlyD_3; pfam13437
1247189002462	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
1247189002463	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
1247189002464	Walker A/P-loop; other site
1247189002465	ATP binding site [chemical binding]; other site
1247189002466	Q-loop/lid; other site
1247189002467	ABC transporter signature motif; other site
1247189002468	Walker B; other site
1247189002469	D-loop; other site
1247189002470	H-loop/switch region; other site
1247189002471	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
1247189002472	ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577
1247189002473	FtsX-like permease family; Region: FtsX; pfam02687
1247189002474	SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335
1247189002475	Membrane domain of glycerophosphoryl diester phosphodiesterase; Region: GPDPase_memb; cl01974
1247189002476	Membrane domain of glycerophosphoryl diester phosphodiesterase; Region: GPDPase_memb; cl01974
1247189002477	Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584
1247189002478	Glycerophosphodiester phosphodiesterase domain of uncharacterized bacterial glycerophosphodiester phosphodiesterases; Region: GDPD_memb_like; cd08579
1247189002479	putative active site [active]
1247189002480	catalytic site [active]
1247189002481	putative metal binding site [ion binding]; other site
1247189002482	Predicted RNA-binding protein (contains KH domain) [General function prediction only]; Region: COG1837
1247189002483	KH domain; Region: KH_4; pfam13083
1247189002484	G-X-X-G motif; other site
1247189002485	Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620
1247189002486	Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620
1247189002487	16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK00122
1247189002488	RimM N-terminal domain; Region: RimM; pfam01782
1247189002489	PRC-barrel domain; Region: PRC; pfam05239
1247189002490	tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026
1247189002491	Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492
1247189002492	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
1247189002493	Predicted membrane protein, putative toxin regulator [General function prediction only]; Region: PfoR; COG3641
1247189002494	Phosphotransferase system, EIIC; Region: PTS_EIIC_2; pfam13303
1247189002495	2-dehydropantoate 2-reductase; Reviewed; Region: PRK06522
1247189002496	Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558
1247189002497	Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546
1247189002498	helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420
1247189002499	Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349
1247189002500	DeoR C terminal sensor domain; Region: DeoRC; pfam00455
1247189002501	Fructose-1-phosphate kinase and related fructose-6-phosphate kinase (PfkB) [Carbohydrate transport and metabolism]; Region: FruK; COG1105
1247189002502	1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164
1247189002503	putative substrate binding site [chemical binding]; other site
1247189002504	putative ATP binding site [chemical binding]; other site
1247189002505	PTS system 2-O-a-mannosyl-D-glycerate specific transporter subunit IIABC; Provisional; Region: PRK09765
1247189002506	PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211
1247189002507	active site
1247189002508	phosphorylation site [posttranslational modification]
1247189002509	PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569
1247189002510	active site
1247189002511	P-loop; other site
1247189002512	phosphorylation site [posttranslational modification]
1247189002513	Phosphotransferase system, fructose-specific IIC component [Carbohydrate transport and metabolism]; Region: FruA; COG1299
1247189002514	Mannosyl-glycoprotein endo-beta-N-acetylglucosaminidase; Region: Glucosaminidase; cl17361
1247189002515	Mannosyl-glycoprotein endo-beta-N-acetylglucosaminidase; Region: Glucosaminidase; cl17361
1247189002516	Muramidase (flagellum-specific) [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FlgJ; COG1705
1247189002517	Protein of unknown function (DUF1149); Region: DUF1149; pfam06619
1247189002518	EDD domain protein, DegV family; Region: DegV; TIGR00762
1247189002519	Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645
1247189002520	tRNA CCA-pyrophosphorylase; Provisional; Region: PRK13299
1247189002521	Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398
1247189002522	active site
1247189002523	NTP binding site [chemical binding]; other site
1247189002524	metal binding triad [ion binding]; metal-binding site
1247189002525	Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627
1247189002526	tRNA nucleotidyltransferase domain 2 putative; Region: tRNA_NucTran2_2; pfam13735
1247189002527	ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488
1247189002528	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1247189002529	Walker A/P-loop; other site
1247189002530	ATP binding site [chemical binding]; other site
1247189002531	Q-loop/lid; other site
1247189002532	ABC transporter signature motif; other site
1247189002533	Walker B; other site
1247189002534	D-loop; other site
1247189002535	H-loop/switch region; other site
1247189002536	ABC transporter; Region: ABC_tran_2; pfam12848
1247189002537	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
1247189002538	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
1247189002539	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
1247189002540	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1247189002541	Walker A/P-loop; other site
1247189002542	ATP binding site [chemical binding]; other site
1247189002543	Q-loop/lid; other site
1247189002544	ABC transporter signature motif; other site
1247189002545	Walker B; other site
1247189002546	D-loop; other site
1247189002547	H-loop/switch region; other site
1247189002548	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
1247189002549	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
1247189002550	ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254
1247189002551	Walker A/P-loop; other site
1247189002552	ATP binding site [chemical binding]; other site
1247189002553	Q-loop/lid; other site
1247189002554	ABC transporter signature motif; other site
1247189002555	Walker B; other site
1247189002556	D-loop; other site
1247189002557	H-loop/switch region; other site
1247189002558	glutamate dehydrogenase; Provisional; Region: PRK09414
1247189002559	Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812
1247189002560	NAD(P) binding domain of glutamate dehydrogenase, subgroup 2; Region: NAD_bind_2_Glu_DH; cd05313
1247189002561	NAD(P) binding site [chemical binding]; other site
1247189002562	Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487
1247189002563	active site
1247189002564	catalytic residues [active]
1247189002565	metal binding site [ion binding]; metal-binding site
1247189002566	5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737
1247189002567	Bacillus subtilis YhcR endonuclease and related proteins, N-terminal metallophosphatase domain; Region: MPP_YhcR_N; cd07412
1247189002568	putative active site [active]
1247189002569	putative metal binding site [ion binding]; other site
1247189002570	5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872
1247189002571	Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399
1247189002572	synthetase active site [active]
1247189002573	NTP binding site [chemical binding]; other site
1247189002574	metal binding site [ion binding]; metal-binding site
1247189002575	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
1247189002576	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1247189002577	active site
1247189002578	phosphorylation site [posttranslational modification]
1247189002579	intermolecular recognition site; other site
1247189002580	dimerization interface [polypeptide binding]; other site
1247189002581	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
1247189002582	DNA binding site [nucleotide binding]
1247189002583	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
1247189002584	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
1247189002585	dimer interface [polypeptide binding]; other site
1247189002586	phosphorylation site [posttranslational modification]
1247189002587	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1247189002588	ATP binding site [chemical binding]; other site
1247189002589	Mg2+ binding site [ion binding]; other site
1247189002590	G-X-G motif; other site
1247189002591	mevalonate kinase; Region: mevalon_kin; TIGR00549
1247189002592	GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288
1247189002593	Mevalonate kinase [Lipid metabolism]; Region: ERG12; COG1577
1247189002594	diphosphomevalonate decarboxylase; Region: mevDPdecarb; TIGR01240
1247189002595	diphosphomevalonate decarboxylase; Region: PLN02407
1247189002596	Mevalonate kinase [Lipid metabolism]; Region: ERG12; COG1577
1247189002597	GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288
1247189002598	GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544
1247189002599	isopentenyl pyrophosphate isomerase; Provisional; Region: PRK05437
1247189002600	Isopentenyl-diphosphate:dimethylallyl diphosphate isomerase type 2 (IDI-2) FMN-binding domain. Two types of IDIs have been characterized at present. The long known IDI-1 is only dependent on divalent metals for activity, whereas IDI-2 requires a metal; Region: IDI-2_FMN; cd02811
1247189002601	homotetramer interface [polypeptide binding]; other site
1247189002602	FMN binding site [chemical binding]; other site
1247189002603	homodimer contacts [polypeptide binding]; other site
1247189002604	putative active site [active]
1247189002605	putative substrate binding site [chemical binding]; other site
1247189002606	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963
1247189002607	Transposase; Region: HTH_Tnp_1; pfam01527
1247189002608	HTH-like domain; Region: HTH_21; pfam13276
1247189002609	Integrase core domain; Region: rve; pfam00665
1247189002610	ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase; Region: ribokinase_pfkB_like; cl00192
1247189002611	ATP binding site [chemical binding]; other site
1247189002612	substrate binding site [chemical binding]; other site
1247189002613	ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase; Region: ribokinase_pfkB_like; cl00192
1247189002614	Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349
1247189002615	helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420
1247189002616	DeoR C terminal sensor domain; Region: DeoRC; pfam00455
1247189002617	PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211
1247189002618	active site
1247189002619	phosphorylation site [posttranslational modification]
1247189002620	PTS_IIB_galactitol: subunit IIB of enzyme II (EII) of the galactitol-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS).  In this system, EII is a galactitol-specific permease with two cytoplasmic domains (IIA and IIB) and a...; Region: PTS_IIB_galactitol; cd05566
1247189002621	active site
1247189002622	P-loop; other site
1247189002623	phosphorylation site [posttranslational modification]
1247189002624	PTS system sugar-specific permease component; Region: EIIC-GAT; cl04451
1247189002625	PTS system sugar-specific permease component; Region: EIIC-GAT; cl04451
1247189002626	Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cl00214
1247189002627	active site
1247189002628	intersubunit interface [polypeptide binding]; other site
1247189002629	Zn2+ binding site [ion binding]; other site
1247189002630	Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429
1247189002631	Pentose-5-phosphate-3-epimerase [Carbohydrate transport and metabolism]; Region: Rpe; COG0036
1247189002632	hexamer interface [polypeptide binding]; other site
1247189002633	metal binding site [ion binding]; metal-binding site
1247189002634	substrate binding site [chemical binding]; other site
1247189002635	Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826
1247189002636	Integrase core domain; Region: rve; pfam00665
1247189002637	Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826
1247189002638	Helix-turn-helix domain; Region: HTH_38; pfam13936
1247189002639	Transposase, Mutator family; Region: Transposase_mut; pfam00872
1247189002640	Transposase; Region: HTH_Tnp_1; pfam01527
1247189002641	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963
1247189002642	HTH-like domain; Region: HTH_21; pfam13276
1247189002643	Integrase core domain; Region: rve; pfam00665
1247189002644	Transposase, Mutator family; Region: Transposase_mut; pfam00872
1247189002645	Hydroxymethylglutaryl-coenzyme A (HMG-CoA) reductase (HMGR); Region: HMG-CoA_reductase; cl00205
1247189002646	substrate binding pocket [chemical binding]; other site
1247189002647	catalytic residues [active]
1247189002648	Hydroxymethylglutaryl-coenzyme A (HMG-CoA) reductase (HMGR); Region: HMG-CoA_reductase; cl00205
1247189002649	helix swapped region; other site
1247189002650	homodimer interface [polypeptide binding]; other site
1247189002651	NADH/NADPH cofactor binding site [chemical binding]; other site
1247189002652	"initiating" condensing enzymes are a subclass of decarboxylating condensing enzymes, including beta-ketoacyl [ACP] synthase, type III and polyketide synthases, type III, which include chalcone synthase and related enzymes. They are...; Region: init_cond_enzymes; cd00827
1247189002653	3-hydroxy-3-methylglutaryl CoA synthase, prokaryotic clade; Region: HMG-CoA-S_prok; TIGR01835
1247189002654	dimer interface [polypeptide binding]; other site
1247189002655	active site
1247189002656	thymidylate synthase; Reviewed; Region: thyA; PRK01827
1247189002657	Thymidylate synthase and pyrimidine hydroxymethylase: Thymidylate synthase (TS) and deoxycytidylate hydroxymethylase (dCMP-HMase) are homologs that catalyze analogous alkylation of C5 of pyrimidine nucleotides. Both enzymes are involved in the...; Region: TS_Pyrimidine_HMase; cd00351
1247189002658	dimerization interface [polypeptide binding]; other site
1247189002659	active site
1247189002660	Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cd00209
1247189002661	Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262
1247189002662	folate binding site [chemical binding]; other site
1247189002663	NADP+ binding site [chemical binding]; other site
1247189002664	ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342
1247189002665	ClpX C4-type zinc finger; Region: zf-C4_ClpX; pfam06689
1247189002666	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1247189002667	Walker A motif; other site
1247189002668	ATP binding site [chemical binding]; other site
1247189002669	Walker B motif; other site
1247189002670	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086
1247189002671	YihA (EngB) GTPase family; Region: YihA_EngB; cd01876
1247189002672	G1 box; other site
1247189002673	GTP/Mg2+ binding site [chemical binding]; other site
1247189002674	Switch I region; other site
1247189002675	G2 box; other site
1247189002676	G3 box; other site
1247189002677	Switch II region; other site
1247189002678	G4 box; other site
1247189002679	G5 box; other site
1247189002680	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1247189002681	ATPases associated with a variety of cellular activities; Region: AAA; smart00382
1247189002682	Walker A motif; other site
1247189002683	ATP binding site [chemical binding]; other site
1247189002684	Walker B motif; other site
1247189002685	arginine finger; other site
1247189002686	UvrB/uvrC motif; Region: UVR; pfam02151
1247189002687	MoxR-like ATPases [General function prediction only]; Region: COG0714
1247189002688	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1247189002689	Walker A motif; other site
1247189002690	ATP binding site [chemical binding]; other site
1247189002691	Walker B motif; other site
1247189002692	arginine finger; other site
1247189002693	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431
1247189002694	Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797
1247189002695	23S rRNA interface [nucleotide binding]; other site
1247189002696	Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site
1247189002697	Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387
1247189002698	core dimer interface [polypeptide binding]; other site
1247189002699	L10 interface [polypeptide binding]; other site
1247189002700	L11 interface [polypeptide binding]; other site
1247189002701	putative EF-Tu interaction site [polypeptide binding]; other site
1247189002702	putative EF-G interaction site [polypeptide binding]; other site
1247189002703	HTH-like domain; Region: HTH_21; pfam13276
1247189002704	Integrase core domain; Region: rve; pfam00665
1247189002705	Integrase core domain; Region: rve_3; cl15866
1247189002706	Transposase; Region: HTH_Tnp_1; pfam01527
1247189002707	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963
1247189002708	Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349
1247189002709	DeoR C terminal sensor domain; Region: DeoRC; pfam00455
1247189002710	galactose-6-phosphate isomerase subunit LacA; Reviewed; Region: PRK08621
1247189002711	galactose-6-phosphate isomerase subunit LacB; Reviewed; Region: PRK08622
1247189002712	1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164
1247189002713	tagatose-6-phosphate kinase; Region: lacC; TIGR01231
1247189002714	putative substrate binding site [chemical binding]; other site
1247189002715	putative ATP binding site [chemical binding]; other site
1247189002716	tagatose 1,6-diphosphate aldolase; Reviewed; Region: PRK12399
1247189002717	CAT RNA binding domain; Region: CAT_RBD; smart01061
1247189002718	transcriptional antiterminator BglG; Provisional; Region: PRK09772
1247189002719	PRD domain; Region: PRD; pfam00874
1247189002720	PRD domain; Region: PRD; pfam00874
1247189002721	PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_lac; cd00215
1247189002722	methionine cluster; other site
1247189002723	active site
1247189002724	phosphorylation site [posttranslational modification]
1247189002725	metal binding site [ion binding]; metal-binding site
1247189002726	phosphotransferase system, lactose specific, IIC component; Region: lac_pts_IIC; TIGR00394
1247189002727	Phosphotransferase system, EIIC; Region: PTS_EIIC; pfam02378
1247189002728	PTS_IIB: subunit IIB of enzyme II (EII) is the central energy-coupling domain of the phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In the multienzyme PTS complex, EII is a carbohydrate-specific permease consisting of two cytoplasmic...; Region: PTS_IIB; cl10014
1247189002729	active site
1247189002730	P-loop; other site
1247189002731	phosphorylation site [posttranslational modification]
1247189002732	6-phospho-beta-galactosidase; Provisional; Region: PRK13511
1247189002733	beta-galactosidase; Region: BGL; TIGR03356
1247189002734	Protein of unknown function (DUF3884); Region: DUF3884; pfam13024
1247189002735	Aldose 1-epimerase, similar to Lactococcus lactis lacX; Region: Aldose_epim_lacX; cd09024
1247189002736	active site
1247189002737	catalytic residues [active]
1247189002738	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
1247189002739	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
1247189002740	non-specific DNA binding site [nucleotide binding]; other site
1247189002741	salt bridge; other site
1247189002742	sequence-specific DNA binding site [nucleotide binding]; other site
1247189002743	Domain of unknown function (DUF3173); Region: DUF3173; pfam11372
1247189002744	phiLC3 phage and phage-related integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes various bacterial (mainly gram positive) and phage integrases, including those similar to Lactococcus...; Region: INT_phiLC3_C; cd01189
1247189002745	Int/Topo IB signature motif; other site
1247189002746	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
1247189002747	Transposase DDE domain; Region: DDE_Tnp_1_3; pfam13612
1247189002748	D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: DacC; COG1686
1247189002749	Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872
1247189002750	Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; smart00936
1247189002751	Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726
1247189002752	Putative catalytic NodB homology domain of PgaB, IcaB, and similar proteins which consist of a deformed (beta/alpha)8 barrel fold with 5- or 6-strands; Region: CE4_NodB_like_5s_6s; cd10918
1247189002753	putative active site [active]
1247189002754	putative metal binding site [ion binding]; other site
1247189002755	homoserine dehydrogenase; Provisional; Region: PRK06349
1247189002756	Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447
1247189002757	Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742
1247189002758	homoserine kinase; Provisional; Region: PRK01212
1247189002759	GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288
1247189002760	folylpolyglutamate synthase/dihydrofolate synthase; Region: folC; TIGR01499
1247189002761	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
1247189002762	GTP cyclohydrolase I (GTP-CH-I) catalyzes the conversion of GTP into dihydroneopterin triphosphate.  The enzyme product is the precursor of tetrahydrofolate in eubacteria, fungi, and plants and of the folate analogs in methanogenic bacteria.  In...; Region: GTP_cyclohydro1; cd00642
1247189002763	homodecamer interface [polypeptide binding]; other site
1247189002764	GTP cyclohydrolase I; Provisional; Region: PLN03044
1247189002765	active site
1247189002766	putative catalytic site residues [active]
1247189002767	zinc binding site [ion binding]; other site
1247189002768	GTP-CH-I/GFRP interaction surface; other site
1247189002769	DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739
1247189002770	dihydropteroate synthase; Region: DHPS; TIGR01496
1247189002771	substrate binding pocket [chemical binding]; other site
1247189002772	dimer interface [polypeptide binding]; other site
1247189002773	inhibitor binding site; inhibition site
1247189002774	Dihydroneopterin aldolase (DHNA) and 7,8-dihydroneopterin triphosphate epimerase domain (DHNTPE); these enzymes have been designated folB and folX, respectively. Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and...; Region: DHNA_DHNTPE; cd00534
1247189002775	homooctamer interface [polypeptide binding]; other site
1247189002776	active site
1247189002777	7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483
1247189002778	catalytic center binding site [active]
1247189002779	ATP binding site [chemical binding]; other site
1247189002780	UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK13905
1247189002781	FAD binding domain; Region: FAD_binding_4; pfam01565
1247189002782	UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873
1247189002783	ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842
1247189002784	ATP-binding cassette domain of the polyamine transporter; Region: ABC_PotA_N; cd03300
1247189002785	Walker A/P-loop; other site
1247189002786	ATP binding site [chemical binding]; other site
1247189002787	Q-loop/lid; other site
1247189002788	ABC transporter signature motif; other site
1247189002789	Walker B; other site
1247189002790	D-loop; other site
1247189002791	H-loop/switch region; other site
1247189002792	TOBE domain; Region: TOBE_2; pfam08402
1247189002793	sulfate transport protein; Provisional; Region: cysT; CHL00187
1247189002794	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1247189002795	dimer interface [polypeptide binding]; other site
1247189002796	conserved gate region; other site
1247189002797	putative PBP binding loops; other site
1247189002798	ABC-ATPase subunit interface; other site
1247189002799	ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177
1247189002800	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1247189002801	dimer interface [polypeptide binding]; other site
1247189002802	conserved gate region; other site
1247189002803	putative PBP binding loops; other site
1247189002804	ABC-ATPase subunit interface; other site
1247189002805	Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687
1247189002806	Bacterial extracellular solute-binding protein; Region: SBP_bac_6; pfam13343
1247189002807	Response regulator of citrate/malate metabolism [Transcription / Signal transduction mechanisms]; Region: CitB; COG4565
1247189002808	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1247189002809	active site
1247189002810	phosphorylation site [posttranslational modification]
1247189002811	intermolecular recognition site; other site
1247189002812	dimerization interface [polypeptide binding]; other site
1247189002813	Signal transduction histidine kinase regulating citrate/malate metabolism [Signal transduction mechanisms]; Region: CitA; COG3290
1247189002814	Signal transduction histidine kinase regulating citrate/malate metabolism [Signal transduction mechanisms]; Region: CitA; COG3290
1247189002815	Signal transduction histidine kinase regulating citrate/malate metabolism [Signal transduction mechanisms]; Region: CitA; COG3290
1247189002816	2-hydroxycarboxylate transporter family; Region: 2HCT; cl01386
1247189002817	2-hydroxycarboxylate transporter family; Region: 2HCT; cl01386
1247189002818	Malic enzyme [Energy production and conversion]; Region: SfcA; COG0281
1247189002819	Malic enzyme, N-terminal domain; Region: malic; pfam00390
1247189002820	NAD(P) binding domain of malic enzyme (ME), subgroup 2; Region: NAD_bind_2_malic_enz; cd05311
1247189002821	putative NAD(P) binding site [chemical binding]; other site
1247189002822	ClC chloride channel EriC.  This domain is found in the EriC chloride transporters that mediate the extreme acid resistance response in eubacteria and archaea. This response allows bacteria to survive in the acidic environments by decarboxylation-linked...; Region: EriC; cd01031
1247189002823	Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038
1247189002824	Cl- selectivity filter; other site
1247189002825	Cl- binding residues [ion binding]; other site
1247189002826	pore gating glutamate residue; other site
1247189002827	dimer interface [polypeptide binding]; other site
1247189002828	H+/Cl- coupling transport residue; other site
1247189002829	AraC-like ligand binding domain; Region: AraC_binding; pfam02311
1247189002830	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
1247189002831	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1247189002832	NnaC (CMP-NeuNAc synthetase) _like subfamily of SGNH_hydrolases, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its...; Region: NnaC_like; cd01841
1247189002833	active site
1247189002834	catalytic triad [active]
1247189002835	oxyanion hole [active]
1247189002836	Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628
1247189002837	Domain of unknown function DUF20; Region: UPF0118; pfam01594
1247189002838	hypothetical protein; Reviewed; Region: PRK00024
1247189002839	Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071
1247189002840	MPN+ (JAMM) motif; other site
1247189002841	Zinc-binding site [ion binding]; other site
1247189002842	Predicted glutamine amidotransferases [General function prediction only]; Region: COG2071
1247189002843	Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_2; cd01745
1247189002844	catalytic triad [active]
1247189002845	AT-rich DNA-binding protein [General function prediction only]; Region: COG2344
1247189002846	Putative DNA-binding protein N-terminus; Region: Put_DNA-bind_N; pfam06971
1247189002847	CoA binding domain; Region: CoA_binding; pfam02629
1247189002848	Putative amino acid metabolism; Region: DUF1831; pfam08866
1247189002849	Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104
1247189002850	cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402
1247189002851	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
1247189002852	catalytic residue [active]
1247189002853	ribose-phosphate pyrophosphokinase; Provisional; Region: PRK02458
1247189002854	N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793
1247189002855	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
1247189002856	active site
1247189002857	Uncharacterized subgroup 1 of the CYTH-like superfamily; Region: CYTH-like_Pase_1; cd07762
1247189002858	putative active site [active]
1247189002859	putative metal binding residues [ion binding]; other site
1247189002860	signature motif; other site
1247189002861	putative triphosphate binding site [ion binding]; other site
1247189002862	Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399
1247189002863	synthetase active site [active]
1247189002864	NTP binding site [chemical binding]; other site
1247189002865	metal binding site [ion binding]; metal-binding site
1247189002866	inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK04885
1247189002867	ATP-NAD kinase; Region: NAD_kinase; pfam01513
1247189002868	Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564
1247189002869	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cl09940
1247189002870	RNA binding surface [nucleotide binding]; other site
1247189002871	Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869
1247189002872	active site
1247189002873	phosphotransacetylase; Reviewed; Region: eutD; PRK09653
1247189002874	malonic semialdehyde reductase; Provisional; Region: PRK10538
1247189002875	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
1247189002876	NAD(P) binding site [chemical binding]; other site
1247189002877	active site
1247189002878	ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116
1247189002879	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1247189002880	Walker A/P-loop; other site
1247189002881	ATP binding site [chemical binding]; other site
1247189002882	Q-loop/lid; other site
1247189002883	ABC transporter signature motif; other site
1247189002884	Walker B; other site
1247189002885	D-loop; other site
1247189002886	H-loop/switch region; other site
1247189002887	ABC-type proline/glycine betaine transport systems, permease component [Amino acid transport and metabolism]; Region: OpuBB; COG1174
1247189002888	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427
1247189002889	Periplasmic glycine betaine/choline-binding (lipo)protein of an ABC-type transport system (osmoprotectant binding protein) [Cell envelope biogenesis, outer membrane]; Region: OpuBC; COG1732
1247189002890	ABC-type proline/glycine betaine transport systems, periplasmic components [Amino acid transport and metabolism]; Region: ProX; cl17891
1247189002891	guanosine 5'-monophosphate oxidoreductase; Provisional; Region: PRK05458
1247189002892	IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381
1247189002893	active site
1247189002894	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
1247189002895	active site
1247189002896	xanthine permease; Region: pbuX; TIGR03173
1247189002897	Membrane-associated lipoprotein involved in thiamine biosynthesis [Coenzyme metabolism]; Region: ApbE; COG1477
1247189002898	ApbE family; Region: ApbE; pfam02424
1247189002899	4-oxalocrotonate tautomerase; Provisional; Region: PRK02289
1247189002900	active site 1 [active]
1247189002901	dimer interface [polypeptide binding]; other site
1247189002902	hexamer interface [polypeptide binding]; other site
1247189002903	active site 2 [active]
1247189002904	thymidine kinase; Provisional; Region: PRK04296
1247189002905	peptide chain release factor 1; Validated; Region: prfA; PRK00591
1247189002906	This domain is found in peptide chain release factors; Region: PCRF; smart00937
1247189002907	RF-1 domain; Region: RF-1; pfam00472
1247189002908	RF-1 domain; Region: RF-1; pfam00472
1247189002909	N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328
1247189002910	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1247189002911	S-adenosylmethionine binding site [chemical binding]; other site
1247189002912	Putative translation factor (SUA5) [Translation, ribosomal structure and biogenesis]; Region: SUA5; COG0009
1247189002913	Acetyltransferases [General function prediction only]; Region: RimI; COG0456
1247189002914	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
1247189002915	Coenzyme A binding pocket [chemical binding]; other site
1247189002916	serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011
1247189002917	Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378
1247189002918	dimer interface [polypeptide binding]; other site
1247189002919	active site
1247189002920	glycine-pyridoxal phosphate binding site [chemical binding]; other site
1247189002921	folate binding site [chemical binding]; other site
1247189002922	37-kD nucleoid-associated bacterial protein; Region: NA37; cl15473
1247189002923	Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741
1247189002924	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
1247189002925	N-acetyl-D-glucosamine binding site [chemical binding]; other site
1247189002926	catalytic residue [active]
1247189002927	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
1247189002928	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
1247189002929	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1247189002930	Walker A/P-loop; other site
1247189002931	ATP binding site [chemical binding]; other site
1247189002932	Q-loop/lid; other site
1247189002933	ABC transporter signature motif; other site
1247189002934	Walker B; other site
1247189002935	D-loop; other site
1247189002936	H-loop/switch region; other site
1247189002937	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
1247189002938	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
1247189002939	ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254
1247189002940	Walker A/P-loop; other site
1247189002941	ATP binding site [chemical binding]; other site
1247189002942	Q-loop/lid; other site
1247189002943	ABC transporter signature motif; other site
1247189002944	Walker B; other site
1247189002945	D-loop; other site
1247189002946	H-loop/switch region; other site
1247189002947	coenzyme A disulfide reductase; Reviewed; Region: PRK09564
1247189002948	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
1247189002949	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
1247189002950	RibD C-terminal domain; Region: RibD_C; cl17279
1247189002951	Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262
1247189002952	L-2-hydroxyisocapronate dehydrogenases and some bacterial L-lactate dehydrogenases; Region: HicDH_like; cd05291
1247189002953	L-lactate dehydrogenase; Reviewed; Region: ldh; PRK00066
1247189002954	NAD binding site [chemical binding]; other site
1247189002955	dimer interface [polypeptide binding]; other site
1247189002956	tetramer (dimer of dimers) interface [polypeptide binding]; other site
1247189002957	substrate binding site [chemical binding]; other site
1247189002958	DNA gyrase subunit A; Validated; Region: PRK05560
1247189002959	DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187
1247189002960	CAP-like domain; other site
1247189002961	active site
1247189002962	primary dimer interface [polypeptide binding]; other site
1247189002963	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
1247189002964	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
1247189002965	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
1247189002966	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
1247189002967	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
1247189002968	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
1247189002969	Sortase A (SrtA) or subfamily-1 sortases are cysteine transpeptidases found in gram-positive bacteria that anchor surface proteins to peptidoglycans of the bacterial cell wall envelope. They do so by catalyzing a transpeptidation reaction in which the...; Region: Sortase_A_1; cd06165
1247189002970	active site
1247189002971	catalytic site [active]
1247189002972	This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_1; cd08352
1247189002973	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
1247189002974	putative metal binding site [ion binding]; other site
1247189002975	Protein of unknown function, DUF576; Region: DUF576; cl04553
1247189002976	Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+.  Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262
1247189002977	Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+.  Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262
1247189002978	intersubunit interface [polypeptide binding]; other site
1247189002979	Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297
1247189002980	Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+.  Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262
1247189002981	streptococcal histidine triad protein; Region: strep_his_triad; TIGR01363
1247189002982	Predicted secreted protein [Function unknown]; Region: COG4086
1247189002983	Predicted secreted protein [Function unknown]; Region: COG4086
1247189002984	Integrase core domain; Region: rve; pfam00665
1247189002985	Integrase core domain; Region: rve_3; pfam13683
1247189002986	HTH-like domain; Region: HTH_21; pfam13276
1247189002987	Integrase core domain; Region: rve; pfam00665
1247189002988	Transposase; Region: HTH_Tnp_1; pfam01527
1247189002989	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963
1247189002990	HlyD family secretion protein; Region: HlyD_3; pfam13437
1247189002991	Membrane-fusion protein [Cell envelope biogenesis, outer membrane]; Region: AcrA; COG0845
1247189002992	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
1247189002993	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
1247189002994	Walker A/P-loop; other site
1247189002995	ATP binding site [chemical binding]; other site
1247189002996	Q-loop/lid; other site
1247189002997	ABC transporter signature motif; other site
1247189002998	Walker B; other site
1247189002999	D-loop; other site
1247189003000	H-loop/switch region; other site
1247189003001	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
1247189003002	ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577
1247189003003	FtsX-like permease family; Region: FtsX; pfam02687
1247189003004	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
1247189003005	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1247189003006	active site
1247189003007	phosphorylation site [posttranslational modification]
1247189003008	intermolecular recognition site; other site
1247189003009	dimerization interface [polypeptide binding]; other site
1247189003010	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
1247189003011	DNA binding site [nucleotide binding]
1247189003012	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
1247189003013	HAMP domain; Region: HAMP; pfam00672
1247189003014	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
1247189003015	dimer interface [polypeptide binding]; other site
1247189003016	phosphorylation site [posttranslational modification]
1247189003017	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1247189003018	ATP binding site [chemical binding]; other site
1247189003019	Mg2+ binding site [ion binding]; other site
1247189003020	G-X-G motif; other site
1247189003021	Surface antigen [General function prediction only]; Region: COG3942
1247189003022	CHAP domain; Region: CHAP; pfam05257
1247189003023	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3666
1247189003024	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
1247189003025	Peptidase S8 family domain in Streptococcal C5a peptidases; Region: Peptidases_S8_C5a_Peptidase; cd07475
1247189003026	putative active site [active]
1247189003027	catalytic triad [active]
1247189003028	PA_C5a_like: Protease-associated domain containing proteins like Streptococcus pyogenes C5a peptidase. This group contains various PA domain-containing proteins similar to S. pyogenes C5a, including, i) Vpr, a minor extracellular serine protease from...; Region: PA_C5a_like; cd02133
1247189003029	PA/protease domain interface [polypeptide binding]; other site
1247189003030	putative integrin binding motif; other site
1247189003031	Peptidase S8 family domain in Streptococcal C5a peptidases; Region: Peptidases_S8_C5a_Peptidase; cd07475
1247189003032	Fn3-like domain (DUF1034); Region: DUF1034; pfam06280
1247189003033	FlgD Tudor-like domain; Region: FLgD_tudor; pfam13861
1247189003034	ABC-type metal ion transport system, periplasmic component/surface adhesin [Inorganic ion transport and metabolism]; Region: LraI; COG0803
1247189003035	Metal binding protein AcdA.  These proteins have been shown to function in the ABC uptake of Zn2+ and Mn2+ and in competence for genetic transformation and adhesion. The AcdA proteins belong to the TroA superfamily of helical backbone metal receptor...; Region: AdcA; cd01017
1247189003036	metal binding site [ion binding]; metal-binding site
1247189003037	streptococcal histidine triad protein; Region: strep_his_triad; TIGR01363
1247189003038	Streptococcal histidine triad protein; Region: Strep_his_triad; pfam04270
1247189003039	Streptococcal histidine triad protein; Region: Strep_his_triad; pfam04270
1247189003040	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3237
1247189003041	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
1247189003042	cobalt transport protein ATP-binding subunit; Region: cbiO; TIGR01166
1247189003043	Walker A/P-loop; other site
1247189003044	ATP binding site [chemical binding]; other site
1247189003045	Q-loop/lid; other site
1247189003046	ABC transporter signature motif; other site
1247189003047	Walker B; other site
1247189003048	D-loop; other site
1247189003049	H-loop/switch region; other site
1247189003050	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
1247189003051	nickel import ATP-binding protein NikD; Region: nickel_nikD; TIGR02770
1247189003052	Walker A/P-loop; other site
1247189003053	ATP binding site [chemical binding]; other site
1247189003054	Q-loop/lid; other site
1247189003055	ABC transporter signature motif; other site
1247189003056	Walker B; other site
1247189003057	D-loop; other site
1247189003058	H-loop/switch region; other site
1247189003059	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173
1247189003060	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1247189003061	dimer interface [polypeptide binding]; other site
1247189003062	conserved gate region; other site
1247189003063	putative PBP binding loops; other site
1247189003064	ABC-ATPase subunit interface; other site
1247189003065	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601
1247189003066	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1247189003067	dimer interface [polypeptide binding]; other site
1247189003068	conserved gate region; other site
1247189003069	putative PBP binding loops; other site
1247189003070	ABC-ATPase subunit interface; other site
1247189003071	ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747
1247189003072	The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_19; cd08518
1247189003073	Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826
1247189003074	Helix-turn-helix domain; Region: HTH_38; pfam13936
1247189003075	Integrase core domain; Region: rve; pfam00665
1247189003076	FemAB family; Region: FemAB; pfam02388
1247189003077	Acetyltransferase (GNAT) domain; Region: Acetyltransf_6; cl17497
1247189003078	Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482
1247189003079	Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999
1247189003080	Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999
1247189003081	Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482
1247189003082	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3666
1247189003083	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
1247189003084	Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751
1247189003085	GMP synthase; Reviewed; Region: guaA; PRK00074
1247189003086	Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742
1247189003087	AMP/PPi binding site [chemical binding]; other site
1247189003088	candidate oxyanion hole; other site
1247189003089	catalytic triad [active]
1247189003090	potential glutamine specificity residues [chemical binding]; other site
1247189003091	The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997
1247189003092	ATP Binding subdomain [chemical binding]; other site
1247189003093	Dimerization subdomain; other site
1247189003094	Transcriptional regulators [Transcription]; Region: PhnF; COG2188
1247189003095	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
1247189003096	DNA-binding site [nucleotide binding]; DNA binding site
1247189003097	UTRA domain; Region: UTRA; pfam07702
1247189003098	Putative helix-turn-helix protein, YlxM / p13 like; Region: UPF0122; pfam04297
1247189003099	Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569
1247189003100	signal recognition particle protein; Provisional; Region: PRK10867
1247189003101	SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963
1247189003102	The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115
1247189003103	P loop; other site
1247189003104	GTP binding site [chemical binding]; other site
1247189003105	Signal peptide binding domain; Region: SRP_SPB; pfam02978
1247189003106	Ferredoxin reductase (FNR), an FAD and NAD(P) binding protein, was intially identified as a chloroplast reductase activity, catalyzing the electron transfer from reduced iron-sulfur protein ferredoxin to NADP+ as the final step in the electron transport...; Region: FNR_like; cl06868
1247189003107	conserved FAD binding motif [chemical binding]; other site
1247189003108	Ferredoxin reductase (FNR), an FAD and NAD(P) binding protein, was intially identified as a chloroplast reductase activity, catalyzing the electron transfer from reduced iron-sulfur protein ferredoxin to NADP+ as the final step in the electron transport...; Region: FNR_like; cl06868
1247189003109	FAD binding pocket [chemical binding]; other site
1247189003110	phosphate binding motif [ion binding]; other site
1247189003111	beta-alpha-beta structure motif; other site
1247189003112	NAD binding pocket [chemical binding]; other site
1247189003113	Ferredoxin reductase (FNR), an FAD and NAD(P) binding protein, was intially identified as a chloroplast reductase activity, catalyzing the electron transfer from reduced iron-sulfur protein ferredoxin to NADP+ as the final step in the electron transport...; Region: FNR_like; cl06868
1247189003114	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
1247189003115	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
1247189003116	non-specific DNA binding site [nucleotide binding]; other site
1247189003117	salt bridge; other site
1247189003118	sequence-specific DNA binding site [nucleotide binding]; other site
1247189003119	Predicted transcriptional regulator [Transcription]; Region: COG2932
1247189003120	Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529
1247189003121	Catalytic site [active]
1247189003122	putative oxidoreductase; Provisional; Region: PRK10206
1247189003123	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
1247189003124	Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894
1247189003125	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
1247189003126	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1247189003127	active site
1247189003128	phosphorylation site [posttranslational modification]
1247189003129	intermolecular recognition site; other site
1247189003130	dimerization interface [polypeptide binding]; other site
1247189003131	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
1247189003132	DNA binding site [nucleotide binding]
1247189003133	HAMP (Histidine kinases, Adenylyl cyclases, Methyl binding proteins, Phosphatases) domain; Region: HAMP; smart00304
1247189003134	dimerization interface [polypeptide binding]; other site
1247189003135	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
1247189003136	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
1247189003137	dimer interface [polypeptide binding]; other site
1247189003138	phosphorylation site [posttranslational modification]
1247189003139	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1247189003140	ATP binding site [chemical binding]; other site
1247189003141	Mg2+ binding site [ion binding]; other site
1247189003142	G-X-G motif; other site
1247189003143	Mannose-6-phosphate isomerase [Carbohydrate transport and metabolism]; Region: {ManC}; COG0662
1247189003144	Acetyltransferase (GNAT) domain; Region: Acetyltransf_6; cl17497
1247189003145	FemAB family; Region: FemAB; pfam02388
1247189003146	site-specific tyrosine recombinase XerS; Reviewed; Region: xerS; PRK05084
1247189003147	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
1247189003148	active site
1247189003149	DNA binding site [nucleotide binding]
1247189003150	Int/Topo IB signature motif; other site
1247189003151	Listerrria innocua Lin0431  is similar to the N-Utilization Substance G (NusG) N terminal (NGN) insert (DII); Region: Lin0431_like; cd09911
1247189003152	trimer interface [polypeptide binding]; other site
1247189003153	1,4-dihydroxy-2-naphthoate octaprenyltransferase [Coenzyme metabolism]; Region: MenA; cl17224
1247189003154	UbiA prenyltransferase family; Region: UbiA; pfam01040
1247189003155	Membrane-associated lipoprotein involved in thiamine biosynthesis [Coenzyme metabolism]; Region: ApbE; COG1477
1247189003156	ApbE family; Region: ApbE; pfam02424
1247189003157	Major membrane immunogen, membrane-anchored lipoprotein [Function unknown]; Region: COG4939
1247189003158	This conserved region includes the FMN-binding site of the NqrC protein as well as the NosR and NirI regulatory proteins; Region: FMN_bind; smart00900
1247189003159	Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142
1247189003160	Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685
1247189003161	substrate binding pocket [chemical binding]; other site
1247189003162	chain length determination region; other site
1247189003163	substrate-Mg2+ binding site; other site
1247189003164	catalytic residues [active]
1247189003165	aspartate-rich region 1; other site
1247189003166	active site lid residues [active]
1247189003167	aspartate-rich region 2; other site
1247189003168	NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252
1247189003169	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
1247189003170	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
1247189003171	TQO small subunit DoxD; Region: DoxD; pfam04173
1247189003172	Heptaprenyl diphosphate synthase component I; Region: Hpre_diP_synt_I; cl01973
1247189003173	Heptaprenyl diphosphate synthase component I; Region: Hpre_diP_synt_I; pfam07456
1247189003174	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
1247189003175	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1247189003176	ATP binding site [chemical binding]; other site
1247189003177	Mg2+ binding site [ion binding]; other site
1247189003178	G-X-G motif; other site
1247189003179	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
1247189003180	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1247189003181	active site
1247189003182	phosphorylation site [posttranslational modification]
1247189003183	intermolecular recognition site; other site
1247189003184	dimerization interface [polypeptide binding]; other site
1247189003185	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
1247189003186	DNA binding site [nucleotide binding]
1247189003187	FtsX-like permease family; Region: FtsX; pfam02687
1247189003188	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
1247189003189	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
1247189003190	Walker A/P-loop; other site
1247189003191	ATP binding site [chemical binding]; other site
1247189003192	Q-loop/lid; other site
1247189003193	ABC transporter signature motif; other site
1247189003194	Walker B; other site
1247189003195	D-loop; other site
1247189003196	H-loop/switch region; other site
1247189003197	C-terminal processing peptidase family S41; Region: Peptidase_S41; cd06567
1247189003198	Active site serine [active]
1247189003199	PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577
1247189003200	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
1247189003201	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
1247189003202	active site
1247189003203	KMSKS motif; other site
1247189003204	DRE-TIM metallolyase superfamily; Region: DRE_TIM_metallolyase; cl07974
1247189003205	oxaloacetate decarboxylase; Provisional; Region: PRK12331
1247189003206	metal binding site [ion binding]; metal-binding site
1247189003207	Pyruvate carboxylase and Transcarboxylase 5S, carboxyltransferase domain; Region: DRE_TIM_PC_TC_5S; cd07937
1247189003208	active site
1247189003209	catalytic residues [active]
1247189003210	tRNA (uracil-5-)-methyltransferase Gid; Reviewed; Region: PRK05335
1247189003211	Glucose inhibited division protein A; Region: GIDA; pfam01134
1247189003212	Protein of unknown function (DUF3307); Region: DUF3307; pfam11750
1247189003213	Formate/glycerate dehydrogenases, D-specific 2-hydroxy acid dehydrogenases and related dehydrogenases; Region: FDH_GDH_like; cl17240
1247189003214	Formate/glycerate dehydrogenases, D-specific 2-hydroxy acid dehydrogenases and related dehydrogenases; Region: FDH_GDH_like; cl17240
1247189003215	NAD binding site [chemical binding]; other site
1247189003216	Predicted membrane protein, putative toxin regulator [General function prediction only]; Region: PfoR; COG3641
1247189003217	Phosphotransferase system, EIIC; Region: PTS_EIIC_2; pfam13303
1247189003218	Predicted membrane protein, putative toxin regulator [General function prediction only]; Region: PfoR; COG3641
1247189003219	Transcriptional regulator [Transcription]; Region: LysR; COG0583
1247189003220	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1247189003221	Transcriptional regulator [Transcription]; Region: LysR; COG0583
1247189003222	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
1247189003223	dimerization interface [polypeptide binding]; other site
1247189003224	DNA topoisomerase I; Validated; Region: PRK05582
1247189003225	TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I.   Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363
1247189003226	active site
1247189003227	interdomain interaction site; other site
1247189003228	putative metal-binding site [ion binding]; other site
1247189003229	nucleotide binding site [chemical binding]; other site
1247189003230	DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186
1247189003231	domain I; other site
1247189003232	DNA binding groove [nucleotide binding]
1247189003233	phosphate binding site [ion binding]; other site
1247189003234	domain II; other site
1247189003235	domain III; other site
1247189003236	nucleotide binding site [chemical binding]; other site
1247189003237	catalytic site [active]
1247189003238	domain IV; other site
1247189003239	Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396
1247189003240	Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396
1247189003241	DNA recombination-mediator protein A; Region: DNA_processg_A; pfam02481
1247189003242	DNA protecting protein DprA; Region: dprA; TIGR00732
1247189003243	bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182
1247189003244	RNA/DNA hybrid binding site [nucleotide binding]; other site
1247189003245	active site
1247189003246	GTPase YlqF; Reviewed; Region: rbgA; PRK09563
1247189003247	Circularly permuted YlqF GTPase; Region: YlqF; cd01856
1247189003248	GTP/Mg2+ binding site [chemical binding]; other site
1247189003249	G4 box; other site
1247189003250	G5 box; other site
1247189003251	G1 box; other site
1247189003252	Switch I region; other site
1247189003253	G2 box; other site
1247189003254	G3 box; other site
1247189003255	Switch II region; other site
1247189003256	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
1247189003257	non-specific DNA binding site [nucleotide binding]; other site
1247189003258	salt bridge; other site
1247189003259	sequence-specific DNA binding site [nucleotide binding]; other site
1247189003260	transcriptional activator, Rgg/GadR/MutR family, C-terminal domain; Region: RGG_Cterm; TIGR01716
1247189003261	Domain of unknown function (DUF1836); Region: DUF1836; pfam08876
1247189003262	Predicted membrane protein, hemolysin III homolog [General function prediction only]; Region: COG1272
1247189003263	channel protein, hemolysin III family; Region: hlyIII; TIGR01065
1247189003264	Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase [Lipid metabolism / General function prediction only]; Region: LCB5; COG1597
1247189003265	Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781
1247189003266	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3237
1247189003267	ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488
1247189003268	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
1247189003269	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
1247189003270	ABC transporter; Region: ABC_tran_2; pfam12848
1247189003271	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
1247189003272	Staphylokinase/Streptokinase family; Region: Staphylokinase; pfam02821
1247189003273	Predicted membrane protein [Function unknown]; Region: COG4720
1247189003274	Pyridoxal kinase plays a key role in the synthesis of the active coenzyme pyridoxal-5'-phosphate  (PLP), by catalyzing the phosphorylation of the precursor vitamin B6  in the presence of Zn2+ and ATP. Mammals are unable to synthesize PLP de novo and...; Region: pyridoxal_pyridoxamine_kinase; cd01173
1247189003275	dimer interface [polypeptide binding]; other site
1247189003276	pyridoxal binding site [chemical binding]; other site
1247189003277	ATP binding site [chemical binding]; other site
1247189003278	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167
1247189003279	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
1247189003280	DNA-binding site [nucleotide binding]; DNA binding site
1247189003281	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
1247189003282	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
1247189003283	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
1247189003284	catalytic residue [active]
1247189003285	ATP cone domain; Region: ATP-cone; pfam03477
1247189003286	ATP cone domain; Region: ATP-cone; pfam03477
1247189003287	aspartate-semialdehyde dehydrogenase; Provisional; Region: PRK14874
1247189003288	Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859
1247189003289	Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; pfam01118
1247189003290	Semialdehyde dehydrogenase, dimerisation domain; Region: Semialdhyde_dhC; pfam02774
1247189003291	Phosphatidylserine/phosphatidylglycerophosphate/car diolipin synthases and related enzymes [Lipid metabolism]; Region: Cls; COG1502
1247189003292	Putative catalytic domain, repeat 1, of Streptococcus mutans uncharacterized protein SMU_988 and similar proteins; Region: PLDc_SMU_988_like_1; cd09154
1247189003293	putative active site [active]
1247189003294	catalytic site [active]
1247189003295	Putative catalytic domain, repeat 2, of Streptococcus mutans uncharacterized protein SMU_988 and similar proteins; Region: PLDc_SMU_988_like_2; cd09160
1247189003296	putative active site [active]
1247189003297	catalytic site [active]
1247189003298	LPXTG-motif cell wall anchor domain; Region: LPXTG_anchor; TIGR01167
1247189003299	Integrase core domain; Region: rve_3; pfam13683
1247189003300	Transposase; Region: HTH_Tnp_1; pfam01527
1247189003301	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963
1247189003302	HTH-like domain; Region: HTH_21; pfam13276
1247189003303	Integrase core domain; Region: rve; pfam00665
1247189003304	Integrase core domain; Region: rve_3; cl15866
1247189003305	Transposase; Region: HTH_Tnp_1; pfam01527
1247189003306	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963
1247189003307	Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826
1247189003308	Helix-turn-helix domain; Region: HTH_38; pfam13936
1247189003309	Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826
1247189003310	Integrase core domain; Region: rve; pfam00665
1247189003311	formate--tetrahydrofolate ligase; Provisional; Region: PRK13505
1247189003312	Formyltetrahydrofolate synthetase (FTHFS) catalyzes the ATP-dependent activation of formate ion via its addition to the N10 position of tetrahydrofolate. FTHFS is a highly expressed key enzyme in both the Wood-Ljungdahl pathway of autotrophic CO2...; Region: FTHFS; cd00477
1247189003313	Potassium binding sites [ion binding]; other site
1247189003314	Cesium cation binding sites [ion binding]; other site
1247189003315	Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095
1247189003316	Bacterial lipoate protein ligase C-terminus; Region: Lip_prot_lig_C; pfam10437
1247189003317	Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095
1247189003318	NAD-dependent protein deacetylases, SIR2 family [Transcription]; Region: SIR2; COG0846
1247189003319	SIR2 superfamily of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+; Region: SIR2; cl00195
1247189003320	Macro domain, Unknown family 1. The macro domain is a high-affinity ADP-ribose binding module found in a variety of proteins as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly ADP-ribose polymerases)...; Region: Macro_1; cd02906
1247189003321	putative ADP-ribose binding site [chemical binding]; other site
1247189003322	Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848
1247189003323	lipoyl attachment site [posttranslational modification]; other site
1247189003324	NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902
1247189003325	Old yellow enzyme (OYE)-related FMN binding domain, group 4.  Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a reducing agent with oxygens, quinones, and alpha,beta-unsaturated aldehydes and ketones, and can act as...; Region: OYE_like_4_FMN; cd04735
1247189003326	putative active site [active]
1247189003327	putative FMN binding site [chemical binding]; other site
1247189003328	putative substrate binding site [chemical binding]; other site
1247189003329	putative catalytic residue [active]
1247189003330	Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095
1247189003331	DNA / pantothenate metabolism flavoprotein; Region: DFP; cl04410
1247189003332	DNA / pantothenate metabolism flavoprotein; Region: DFP; cl04410
1247189003333	phosphopantothenoylcysteine decarboxylase; Validated; Region: PRK07313
1247189003334	Flavoprotein; Region: Flavoprotein; pfam02441
1247189003335	Predicted membrane protein [Function unknown]; Region: COG4684
1247189003336	This CD includes PGM2 (phosphoglucomutase 2) and PGM2L1 (phosphoglucomutase 2-like 1). The mammalian PGM2 is thought to be a phosphopentomutase that catalyzes the conversion of the nucleoside breakdown products, ribose-1-phosphate and...; Region: PGM2; cd05799
1247189003337	Phosphomannomutase [Carbohydrate transport and metabolism]; Region: {ManB}; COG1109
1247189003338	active site
1247189003339	substrate binding site [chemical binding]; other site
1247189003340	metal binding site [ion binding]; metal-binding site
1247189003341	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
1247189003342	Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580
1247189003343	TM-ABC transporter signature motif; other site
1247189003344	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
1247189003345	Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580
1247189003346	TM-ABC transporter signature motif; other site
1247189003347	ABC-type uncharacterized transport systems, ATPase components [General function prediction only]; Region: COG3845
1247189003348	First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216
1247189003349	Walker A/P-loop; other site
1247189003350	ATP binding site [chemical binding]; other site
1247189003351	Q-loop/lid; other site
1247189003352	ABC transporter signature motif; other site
1247189003353	Walker B; other site
1247189003354	D-loop; other site
1247189003355	H-loop/switch region; other site
1247189003356	Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215
1247189003357	Uncharacterized ABC-type transport system, periplasmic component/surface lipoprotein [General function prediction only]; Region: Med; COG1744
1247189003358	Periplasmic binding domain of basic membrane lipoprotein, PnrA, in Treponema pallidum and its homologs from other bacteria and Archaea; Region: PBP1_BmpA_PnrA_like; cd06354
1247189003359	ligand binding site [chemical binding]; other site
1247189003360	Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283
1247189003361	active site
1247189003362	catalytic motif [active]
1247189003363	Zn binding site [ion binding]; other site
1247189003364	2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family; Region: DeoC; cd00959
1247189003365	intersubunit interface [polypeptide binding]; other site
1247189003366	active site
1247189003367	catalytic residue [active]
1247189003368	pyrimidine-nucleoside phosphorylase; Reviewed; Region: PRK06078
1247189003369	Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885
1247189003370	Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591
1247189003371	Pyrimidine nucleoside phosphorylase C-terminal domain; Region: PYNP_C; pfam07831
1247189003372	Methyltransferase domain; Region: Methyltransf_31; pfam13847
1247189003373	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1247189003374	S-adenosylmethionine binding site [chemical binding]; other site
1247189003375	pantothenate kinase; Provisional; Region: PRK05439
1247189003376	Pantothenate kinase (PanK) catalyzes the phosphorylation of pantothenic acid to form 4'-phosphopantothenic, which is the first of five steps in coenzyme A (CoA) biosynthetic pathway. The reaction carried out by this enzyme is a key regulatory point...; Region: PanK; cd02025
1247189003377	ATP-binding site [chemical binding]; other site
1247189003378	CoA-binding site [chemical binding]; other site
1247189003379	Mg2+-binding site [ion binding]; other site
1247189003380	30S ribosomal protein S20; Reviewed; Region: rpsT; PRK00239
1247189003381	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
1247189003382	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
1247189003383	dimer interface [polypeptide binding]; other site
1247189003384	phosphorylation site [posttranslational modification]
1247189003385	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1247189003386	ATP binding site [chemical binding]; other site
1247189003387	Mg2+ binding site [ion binding]; other site
1247189003388	G-X-G motif; other site
1247189003389	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
1247189003390	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1247189003391	active site
1247189003392	phosphorylation site [posttranslational modification]
1247189003393	intermolecular recognition site; other site
1247189003394	dimerization interface [polypeptide binding]; other site
1247189003395	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
1247189003396	DNA binding site [nucleotide binding]
1247189003397	Aminopeptidase N [Amino acid transport and metabolism]; Region: PepN; COG0308
1247189003398	Peptidase M1 Aminopeptidase N family incudes tricorn interacting factor F3, Endoplasmic reticulum aminopeptidase 1 (ERAP1), Aminopeptidase Q (APQ); Region: M1_APN_2; cd09601
1247189003399	Zn binding site [ion binding]; other site
1247189003400	phosphate transport system regulatory protein PhoU; Region: phoU_full; TIGR02135
1247189003401	PhoU domain; Region: PhoU; pfam01895
1247189003402	PhoU domain; Region: PhoU; pfam01895
1247189003403	phosphate transporter ATP-binding protein; Provisional; Region: PRK14239
1247189003404	ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260
1247189003405	Walker A/P-loop; other site
1247189003406	ATP binding site [chemical binding]; other site
1247189003407	Q-loop/lid; other site
1247189003408	ABC transporter signature motif; other site
1247189003409	Walker B; other site
1247189003410	D-loop; other site
1247189003411	H-loop/switch region; other site
1247189003412	phosphate transporter ATP-binding protein; Provisional; Region: PRK14237
1247189003413	ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260
1247189003414	Walker A/P-loop; other site
1247189003415	ATP binding site [chemical binding]; other site
1247189003416	Q-loop/lid; other site
1247189003417	ABC transporter signature motif; other site
1247189003418	Walker B; other site
1247189003419	D-loop; other site
1247189003420	H-loop/switch region; other site
1247189003421	ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstA; COG0581
1247189003422	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1247189003423	dimer interface [polypeptide binding]; other site
1247189003424	conserved gate region; other site
1247189003425	putative PBP binding loops; other site
1247189003426	ABC-ATPase subunit interface; other site
1247189003427	ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstC; COG0573
1247189003428	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1247189003429	dimer interface [polypeptide binding]; other site
1247189003430	conserved gate region; other site
1247189003431	putative PBP binding loops; other site
1247189003432	ABC-ATPase subunit interface; other site
1247189003433	PBP superfamily domain; Region: PBP_like_2; cl17296
1247189003434	rRNA (cytosine-C(5)-)-methyltransferase RsmF; Reviewed; Region: yebU; PRK11933
1247189003435	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1247189003436	S-adenosylmethionine binding site [chemical binding]; other site
1247189003437	pre-rRNA processing and ribosome biogenesis; Region: Nol1_Nop2_Fmu_2; pfam13636
1247189003438	Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483
1247189003439	Inositol-monophosphatase-like domains. This family of phosphatases is dependent on bivalent metal ions such as Mg++, and many members are inhibited by Li+ (which is thought to displace a bivalent ion in the active site). Substrates include fructose-1; Region: IMPase_like; cd01637
1247189003440	active site
1247189003441	hypothetical protein; Provisional; Region: PRK04387
1247189003442	Arsenate Reductase (ArsC) family, Spx subfamily; Spx is a unique RNA polymerase (RNAP)-binding protein present in bacilli and some mollicutes. It inhibits transcription by binding to the C-terminal domain of the alpha subunit of RNAP, disrupting complex...; Region: ArsC_Spx; cd03032
1247189003443	ArsC family; Region: ArsC; pfam03960
1247189003444	putative catalytic residues [active]
1247189003445	thiol/disulfide switch; other site
1247189003446	bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627
1247189003447	FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064
1247189003448	active site
1247189003449	Riboflavin kinase; Region: Flavokinase; pfam01687
1247189003450	tRNA pseudouridine synthase B; Provisional; Region: truB; PRK02484
1247189003451	Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573
1247189003452	RNA binding site [nucleotide binding]; other site
1247189003453	active site
1247189003454	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4487
1247189003455	Uncharacterized protein conserved in bacteria (DUF2130); Region: DUF2130; pfam09903
1247189003456	Predicted membrane protein [Function unknown]; Region: COG4129
1247189003457	Bacterial protein of unknown function (DUF939); Region: DUF939; pfam06081
1247189003458	DUF939 C-terminal domain; Region: DUF939_C; pfam11728
1247189003459	Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459
1247189003460	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
1247189003461	FtsX-like permease family; Region: FtsX; pfam02687
1247189003462	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
1247189003463	ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577
1247189003464	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
1247189003465	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
1247189003466	Walker A/P-loop; other site
1247189003467	ATP binding site [chemical binding]; other site
1247189003468	Q-loop/lid; other site
1247189003469	ABC transporter signature motif; other site
1247189003470	Walker B; other site
1247189003471	D-loop; other site
1247189003472	H-loop/switch region; other site
1247189003473	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
1247189003474	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
1247189003475	Transcriptional regulators [Transcription]; Region: PhnF; COG2188
1247189003476	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
1247189003477	DNA-binding site [nucleotide binding]; DNA binding site
1247189003478	TrkA-C domain; Region: TrkA_C; pfam02080
1247189003479	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1302
1247189003480	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3237
1247189003481	Asp23 family; Region: Asp23; cl00574
1247189003482	Asp23 family; Region: Asp23; cl00574
1247189003483	Small integral membrane protein [Function unknown]; Region: COG5547
1247189003484	Predicted membrane protein [Function unknown]; Region: COG2261
1247189003485	Family description; Region: UvrD_C_2; pfam13538
1247189003486	UvrD/REP helicase N-terminal domain; Region: UvrD-helicase; pfam00580
1247189003487	Part of AAA domain; Region: AAA_19; pfam13245
1247189003488	UvrD-like helicase C-terminal domain; Region: UvrD_C; pfam13361
1247189003489	Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115
1247189003490	amino acid carrier protein; Region: agcS; TIGR00835
1247189003491	Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053
1247189003492	cation diffusion facilitator family transporter; Region: CDF; TIGR01297
1247189003493	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
1247189003494	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3666
1247189003495	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
1247189003496	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
1247189003497	substrate binding pocket [chemical binding]; other site
1247189003498	membrane-bound complex binding site; other site
1247189003499	hinge residues; other site
1247189003500	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
1247189003501	ATP-binding cassette domain of the binding protein-dependent transport systems; Region: ABC_Class3; cd03229
1247189003502	Walker A/P-loop; other site
1247189003503	ATP binding site [chemical binding]; other site
1247189003504	Q-loop/lid; other site
1247189003505	ABC transporter signature motif; other site
1247189003506	Walker B; other site
1247189003507	D-loop; other site
1247189003508	H-loop/switch region; other site
1247189003509	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1247189003510	ABC-ATPase subunit interface; other site
1247189003511	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427
1247189003512	Uncharacterized Zn-ribbon-containing protein involved in phosphonate metabolism [Inorganic ion transport and metabolism]; Region: PhnA; COG2824
1247189003513	PhnA Zinc-Ribbon; Region: PhnA_Zn_Ribbon; pfam08274
1247189003514	PhnA protein; Region: PhnA; pfam03831
1247189003515	glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331
1247189003516	Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans).  The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714
1247189003517	glutaminase active site [active]
1247189003518	SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008
1247189003519	dimer interface [polypeptide binding]; other site
1247189003520	active site
1247189003521	SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009
1247189003522	dimer interface [polypeptide binding]; other site
1247189003523	active site
1247189003524	signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227
1247189003525	The S24, S26 LexA/signal peptidase superfamily contains LexA-related and type I signal peptidase families. The S24 LexA protein domains include: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC 3.4.21.88), the...; Region: Peptidase_S24_S26; cl10465
1247189003526	The S24, S26 LexA/signal peptidase superfamily contains LexA-related and type I signal peptidase families. The S24 LexA protein domains include: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC 3.4.21.88), the...; Region: Peptidase_S24_S26; cl10465
1247189003527	Pyruvate kinase (PK):  Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342
1247189003528	pyruvate kinase; Provisional; Region: PRK05826
1247189003529	Pyruvate kinase (PK):  Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342
1247189003530	domain interfaces; other site
1247189003531	active site
1247189003532	6-phosphofructokinase; Provisional; Region: PRK03202
1247189003533	active site
1247189003534	fructose-1,6-bisphosphate binding site; other site
1247189003535	dimerization interface [polypeptide binding]; other site
1247189003536	allosteric effector site; other site
1247189003537	Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to PFK family that includes ATP- and pyrophosphate (PPi)- dependent phosphofructokinases; Region: PFK; cl00204
1247189003538	DNA polymerase III DnaE; Reviewed; Region: dnaE; PRK07279
1247189003539	Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III; Region: PHP_PolIIIA; cd07431
1247189003540	active site
1247189003541	PHP Thumb interface [polypeptide binding]; other site
1247189003542	DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485
1247189003543	generic binding surface II; other site
1247189003544	generic binding surface I; other site
1247189003545	Predicted transcriptional regulators [Transcription]; Region: COG1725
1247189003546	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
1247189003547	DNA-binding site [nucleotide binding]; DNA binding site
1247189003548	lipopolysaccharide ABC transporter ATP-binding protein; Provisional; Region: PRK10895
1247189003549	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
1247189003550	Walker A/P-loop; other site
1247189003551	ATP binding site [chemical binding]; other site
1247189003552	Q-loop/lid; other site
1247189003553	ABC transporter signature motif; other site
1247189003554	Walker B; other site
1247189003555	D-loop; other site
1247189003556	H-loop/switch region; other site
1247189003557	Uncharacterized conserved protein [Function unknown]; Region: COG0398
1247189003558	SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335
1247189003559	Domain of Unknown Function with PDB structure (DUF3862); Region: DUF3862; pfam12978
1247189003560	Domain of Unknown Function with PDB structure (DUF3862); Region: DUF3862; pfam12978
1247189003561	30S ribosomal protein S1; Reviewed; Region: rpsA; PRK06676
1247189003562	S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687
1247189003563	RNA binding site [nucleotide binding]; other site
1247189003564	S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465
1247189003565	RNA binding site [nucleotide binding]; other site
1247189003566	S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927
1247189003567	RNA binding site [nucleotide binding]; other site
1247189003568	S1_RPS1_repeat_hs4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_hs4; cd05692
1247189003569	RNA binding site [nucleotide binding]; other site
1247189003570	Protein of unknown function (DUF2969); Region: DUF2969; pfam11184
1247189003571	branched-chain amino acid aminotransferase; Provisional; Region: PRK13357
1247189003572	BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids  leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557
1247189003573	homodimer interface [polypeptide binding]; other site
1247189003574	substrate-cofactor binding pocket; other site
1247189003575	catalytic residue [active]
1247189003576	Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cl00264
1247189003577	DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cl00148
1247189003578	primary dimer interface [polypeptide binding]; other site
1247189003579	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
1247189003580	DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cl00148
1247189003581	CAP-like domain; other site
1247189003582	active site
1247189003583	DNA topoisomerase IV, B subunit, Gram-positive; Region: parE_Gpos; TIGR01058
1247189003584	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1247189003585	Mg2+ binding site [ion binding]; other site
1247189003586	G-X-G motif; other site
1247189003587	TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822
1247189003588	anchoring element; other site
1247189003589	dimer interface [polypeptide binding]; other site
1247189003590	ATP binding site [chemical binding]; other site
1247189003591	TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366
1247189003592	active site
1247189003593	putative metal-binding site [ion binding]; other site
1247189003594	DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986
1247189003595	putative glycerol-3-phosphate acyltransferase PlsY; Provisional; Region: PRK00220
1247189003596	dihydroorotase; Validated; Region: pyrC; PRK09357
1247189003597	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
1247189003598	Dihydroorotase (DHOase), subgroup IIa; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This subgroup also contains proteins that lack the active site, like unc-33, a C; Region: DHOase_IIa; cd01317
1247189003599	active site
1247189003600	Family 1 of Uracil-DNA glycosylase (UDG) enzymes; Region: UDG_F1; cd10027
1247189003601	ligand binding site [chemical binding]; other site
1247189003602	active site
1247189003603	UGI interface [polypeptide binding]; other site
1247189003604	catalytic site [active]
1247189003605	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1247189003606	dimer interface [polypeptide binding]; other site
1247189003607	putative PBP binding loops; other site
1247189003608	ABC-ATPase subunit interface; other site
1247189003609	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
1247189003610	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
1247189003611	substrate binding pocket [chemical binding]; other site
1247189003612	membrane-bound complex binding site; other site
1247189003613	hinge residues; other site
1247189003614	amidase; Provisional; Region: PRK06529
1247189003615	Amidase; Region: Amidase; cl11426
1247189003616	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801
1247189003617	Integrase core domain; Region: rve; pfam00665
1247189003618	Integrase core domain; Region: rve_2; pfam13333
1247189003619	Acetyltransferases [General function prediction only]; Region: RimI; COG0456
1247189003620	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
1247189003621	Coenzyme A binding pocket [chemical binding]; other site
1247189003622	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
1247189003623	active site
1247189003624	Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725
1247189003625	active site
1247189003626	dimer interface [polypeptide binding]; other site
1247189003627	Transcriptional regulator [Transcription]; Region: LysR; COG0583
1247189003628	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1247189003629	CRISPR/Cas system-associated protein Csm6; Region: Csm6_III-A; cl09873
1247189003630	purine nucleoside phosphorylase; Reviewed; Region: deoD; PRK05819
1247189003631	purine nucleoside phosphorylase; Provisional; Region: PRK08202
1247189003632	Arsenate Reductase (ArsC) family, ArsC subfamily; arsenic reductases similar to that encoded by arsC on the R733 plasmid of Escherichia coli. E. coli ArsC catalyzes the reduction of arsenate [As(V)] to arsenite [As(III)], the first step in the...; Region: ArsC_ArsC; cd03034
1247189003633	ArsC family; Region: ArsC; pfam03960
1247189003634	catalytic residues [active]
1247189003635	phosphopentomutase; Provisional; Region: PRK05362
1247189003636	Metalloenzyme superfamily; Region: Metalloenzyme; pfam01676
1247189003637	RPI_A: Ribose 5-phosphate isomerase type A (RPI_A) subfamily; RPI catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate, the first step of the non-oxidative branch of the pentose phosphate pathway. This reaction leads to the...; Region: RPI_A; cd01398
1247189003638	tetramer (dimer of dimers) interface [polypeptide binding]; other site
1247189003639	active site
1247189003640	dimer interface [polypeptide binding]; other site
1247189003641	tRNA modification GTPase TrmE; Reviewed; Region: trmE; PRK05291
1247189003642	GTP-binding protein TrmE N-terminus; Region: TrmE_N; pfam10396
1247189003643	trmE is a tRNA modification GTPase; Region: trmE; cd04164
1247189003644	G1 box; other site
1247189003645	GTP/Mg2+ binding site [chemical binding]; other site
1247189003646	Switch I region; other site
1247189003647	G2 box; other site
1247189003648	Switch II region; other site
1247189003649	G3 box; other site
1247189003650	G4 box; other site
1247189003651	G5 box; other site
1247189003652	Catalytic cysteine-containing C-terminus of GTPase, MnmE; Region: GTPase_Cys_C; pfam12631
1247189003653	dipeptidase PepV; Reviewed; Region: PRK07318
1247189003654	M20 Peptidase Xaa-His dipeptidase (PepV) degrades hydrophobic dipeptides; Region: M20_PepV; cd03888
1247189003655	active site
1247189003656	metal binding site [ion binding]; metal-binding site
1247189003657	Nitroreductase-like family 1. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_1; cd02137
1247189003658	dimer interface [polypeptide binding]; other site
1247189003659	FMN binding site [chemical binding]; other site
1247189003660	Pyrimidine (PYR) binding domain of thiamine pyrophosphate (TPP)-dependent enzymes; Region: TPP_enzyme_PYR; cl11410
1247189003661	PYR/PP interface [polypeptide binding]; other site
1247189003662	dimer interface [polypeptide binding]; other site
1247189003663	TPP binding site [chemical binding]; other site
1247189003664	Pyrimidine (PYR) binding domain of thiamine pyrophosphate (TPP)-dependent enzymes; Region: TPP_enzyme_PYR; cl11410
1247189003665	Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205
1247189003666	Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629
1247189003667	Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629
1247189003668	UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459
1247189003669	excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558
1247189003670	Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434
1247189003671	GIY-YIG motif/motif A; other site
1247189003672	active site
1247189003673	catalytic site [active]
1247189003674	putative DNA binding site [nucleotide binding]; other site
1247189003675	metal binding site [ion binding]; metal-binding site
1247189003676	UvrB/uvrC motif; Region: UVR; pfam02151
1247189003677	Predicted hydrolases of the HAD superfamily [General function prediction only]; Region: Cof; COG0561
1247189003678	NAD-dependent aldehyde dehydrogenases [Energy production and conversion]; Region: PutA; COG1012
1247189003679	NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961
1247189003680	catalytic residues [active]
1247189003681	NAD-dependent aldehyde dehydrogenases [Energy production and conversion]; Region: PutA; COG1012
1247189003682	NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961
1247189003683	NAD(P) binding site [chemical binding]; other site
1247189003684	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
1247189003685	motif I; other site
1247189003686	motif II; other site
1247189003687	Protein of unknown function (DUF1524); Region: DUF1524; pfam07510
1247189003688	maltose O-acetyltransferase; Provisional; Region: PRK10092
1247189003689	Maltose O-acetyltransferase (MAT) and Galactoside O-acetyltransferase (GAT): MAT and GAT catalyze the CoA-dependent acetylation of the 6-hydroxyl group of their respective sugar substrates. MAT acetylates maltose and glucose exclusively at the C6...; Region: LbH_MAT_GAT; cd03357
1247189003690	active site
1247189003691	substrate binding site [chemical binding]; other site
1247189003692	trimer interface [polypeptide binding]; other site
1247189003693	CoA binding site [chemical binding]; other site
1247189003694	Predicted phosphatase/phosphohexomutase [General function prediction only]; Region: COG0637
1247189003695	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
1247189003696	motif II; other site
1247189003697	Flagellin N-methylase; Region: FliB; pfam03692
1247189003698	ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840
1247189003699	Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416
1247189003700	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
1247189003701	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1247189003702	Response regulator receiver domain; Region: Response_reg; pfam00072
1247189003703	active site
1247189003704	phosphorylation site [posttranslational modification]
1247189003705	intermolecular recognition site; other site
1247189003706	dimerization interface [polypeptide binding]; other site
1247189003707	AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207
1247189003708	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1247189003709	ATP binding site [chemical binding]; other site
1247189003710	Mg2+ binding site [ion binding]; other site
1247189003711	G-X-G motif; other site
1247189003712	Predicted signal transduction protein with a C-terminal ATPase domain [Signal transduction mechanisms]; Region: COG2972
1247189003713	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054
1247189003714	dimerization interface [polypeptide binding]; other site
1247189003715	Histidine kinase; Region: His_kinase; pfam06580
1247189003716	Phosphotransferase system, mannose/fructose/N-acetylgalactosamine-specific component IID [Carbohydrate transport and metabolism]; Region: ManZ; COG3716
1247189003717	Phosphotransferase system, mannose/fructose/N-acetylgalactosamine-specific component IIC [Carbohydrate transport and metabolism]; Region: ManY; COG3715
1247189003718	PTS_IIB, PTS system, Mannose/sorbose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_man; cd00001
1247189003719	active site
1247189003720	phosphorylation site [posttranslational modification]
1247189003721	PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cl00025
1247189003722	active site
1247189003723	active pocket/dimerization site; other site
1247189003724	phosphorylation site [posttranslational modification]
1247189003725	Predicted membrane protein [Function unknown]; Region: COG2855
1247189003726	Lipase.  Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is "interfacial activation", the process of...; Region: Lipase; cd00741
1247189003727	nucleophilic elbow; other site
1247189003728	catalytic triad; other site
1247189003729	Enterocin A Immunity; Region: EntA_Immun; pfam08951
1247189003730	Class II bacteriocin; Region: Bacteriocin_II; pfam01721
1247189003731	Predicted HD superfamily hydrolase [General function prediction only]; Region: COG1418
1247189003732	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
1247189003733	Zn2+ binding site [ion binding]; other site
1247189003734	Mg2+ binding site [ion binding]; other site
1247189003735	methionine sulfoxide reductase B; Provisional; Region: PRK00222
1247189003736	SelR domain; Region: SelR; pfam01641
1247189003737	Elongation factor Tu GTP binding domain; Region: GTP_EFTU; pfam00009
1247189003738	LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890
1247189003739	G1 box; other site
1247189003740	putative GEF interaction site [polypeptide binding]; other site
1247189003741	GTP/Mg2+ binding site [chemical binding]; other site
1247189003742	Switch I region; other site
1247189003743	G2 box; other site
1247189003744	G3 box; other site
1247189003745	Switch II region; other site
1247189003746	G4 box; other site
1247189003747	Translation elongation factors (GTPases) [Translation, ribosomal structure and biogenesis]; Region: FusA; COG0480
1247189003748	G5 box; other site
1247189003749	lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699
1247189003750	lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane.   LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709
1247189003751	GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421
1247189003752	Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413
1247189003753	active site
1247189003754	multimer interface [polypeptide binding]; other site
1247189003755	DNA/RNA non-specific endonuclease; Region: Endonuclea_NS_2; cl17626
1247189003756	DNA/RNA non-specific endonuclease; Region: Endonuclea_NS_2; cl17626
1247189003757	Acetyltransferase (GNAT) domain; Region: Acetyltransf_7; pfam13508
1247189003758	CHAP domain; Region: CHAP; pfam05257
1247189003759	Bacterial SH3 domain; Region: SH3_5; pfam08460
1247189003760	Small integral membrane protein [Function unknown]; Region: COG5546
1247189003761	Protein of unknown function (DUF1617); Region: DUF1617; pfam07761
1247189003762	gp58-like protein; Region: Gp58; pfam07902
1247189003763	Phage tail protein; Region: Sipho_tail; pfam05709
1247189003764	phage tail tape measure protein, TP901 family, core region; Region: tape_meas_TP901; TIGR01760
1247189003765	phage major tail protein, phi13 family; Region: maj_tail_phi13; TIGR01603
1247189003766	phage major capsid protein, HK97 family; Region: major_cap_HK97; TIGR01554
1247189003767	Phage capsid family; Region: Phage_capsid; pfam05065
1247189003768	Clp protease; Region: CLP_protease; pfam00574
1247189003769	Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_1; cd07016
1247189003770	oligomer interface [polypeptide binding]; other site
1247189003771	active site residues [active]
1247189003772	phage portal protein, HK97 family; Region: portal_HK97; TIGR01537
1247189003773	phage portal protein, HK97 family; Region: portal_HK97; TIGR01537
1247189003774	Phage Terminase; Region: Terminase_1; pfam03354
1247189003775	Phage terminase, small subunit; Region: Terminase_4; cl01525
1247189003776	Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403
1247189003777	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085
1247189003778	active site
1247189003779	INT_SG3, DNA breaking-rejoining enzymes, integrase/recombinases subgroup 3, catalytic domain. The CD contains various predicted bacterial and phage integrase/recombinase sequences for which not much experimental characterization is available; Region: INT_SG3_C; cd01186
1247189003780	Int/Topo IB signature motif; other site
1247189003781	SnoaL-like domain; Region: SnoaL_4; cl17707
1247189003782	Protein of unknown function (DUF1642); Region: DUF1642; pfam07852
1247189003783	Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315
1247189003784	cofactor binding site; other site
1247189003785	substrate interaction site [chemical binding]; other site
1247189003786	Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403
1247189003787	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085
1247189003788	active site
1247189003789	Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629
1247189003790	SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496
1247189003791	dimer interface [polypeptide binding]; other site
1247189003792	ssDNA binding site [nucleotide binding]; other site
1247189003793	tetramer (dimer of dimers) interface [polypeptide binding]; other site
1247189003794	Protein of unknwon function (DUF3310); Region: DUF3310; pfam11753
1247189003795	Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in a group of uncharacterized proteins from bacteria and archaea; Region: NTP-PPase_u3; cd11540
1247189003796	putative metal binding site [ion binding]; other site
1247189003797	N-terminal phage replisome organiser (Phage_rep_org_N); Region: Phage_rep_org_N; pfam09681
1247189003798	Replication initiation and membrane attachment; Region: DnaB_2; pfam07261
1247189003799	Cro/C1-type HTH DNA-binding domain; Region: HTH_26; pfam13443
1247189003800	Prophage antirepressor [Transcription]; Region: COG3617
1247189003801	BRO family, N-terminal domain; Region: Bro-N; smart01040
1247189003802	ORF6C domain; Region: ORF6C; pfam10552
1247189003803	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
1247189003804	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
1247189003805	non-specific DNA binding site [nucleotide binding]; other site
1247189003806	salt bridge; other site
1247189003807	sequence-specific DNA binding site [nucleotide binding]; other site
1247189003808	Predicted transcriptional regulator [Transcription]; Region: COG2932
1247189003809	Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529
1247189003810	Catalytic site [active]
1247189003811	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
1247189003812	active site
1247189003813	Int/Topo IB signature motif; other site
1247189003814	DNA binding site [nucleotide binding]
1247189003815	Predicted membrane protein [Function unknown]; Region: COG4478
1247189003816	HAD-superfamily subfamily IIA hydrolase, TIGR01457; Region: HAD-SF-IIA-hyp2
1247189003817	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
1247189003818	active site
1247189003819	motif I; other site
1247189003820	motif II; other site
1247189003821	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
1247189003822	Acyl-ACP thioesterase [Lipid metabolism]; Region: FatA; COG3884
1247189003823	The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509
1247189003824	active site 2 [active]
1247189003825	active site 1 [active]
1247189003826	The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509
1247189003827	active site 2 [active]
1247189003828	active site 1 [active]
1247189003829	coproporphyrinogen III oxidase; Provisional; Region: PRK08599
1247189003830	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
1247189003831	FeS/SAM binding site; other site
1247189003832	HemN C-terminal domain; Region: HemN_C; pfam06969
1247189003833	phosphoglucosamine mutase; Provisional; Region: glmM; PRK14316
1247189003834	GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802
1247189003835	active site
1247189003836	substrate binding site [chemical binding]; other site
1247189003837	metal binding site [ion binding]; metal-binding site
1247189003838	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4856
1247189003839	YbbR-like protein; Region: YbbR; pfam07949
1247189003840	Uncharacterized conserved protein [Function unknown]; Region: COG1624
1247189003841	DisA bacterial checkpoint controller nucleotide-binding; Region: DisA_N; pfam02457
1247189003842	UDP-N-acetylmuramyl tripeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurE; COG0769
1247189003843	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
1247189003844	Domain of unknown function (DUF1727); Region: DUF1727; pfam08353
1247189003845	Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020
1247189003846	Type 1 glutamine amidotransferase (GATase1) domain found in Cobyric Acid Synthase (CobQ); Region: GATase1_CobQ; cd01750
1247189003847	catalytic triad [active]
1247189003848	Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095
1247189003849	lipoyltransferase and lipoate-protein ligase; Region: lipoyltrans; TIGR00545
1247189003850	Bacterial lipoate protein ligase C-terminus; Region: Lip_prot_lig_C; pfam10437
1247189003851	Predicted membrane protein [Function unknown]; Region: COG4709
1247189003852	Domain of unknown function (DUF4097); Region: DUF4097; pfam13349
1247189003853	Domain of unknown function (DUF4098); Region: DUF4098; pfam13345
1247189003854	Domain of unknown function (DUF4098); Region: DUF4098; pfam13345
1247189003855	Predicted transcriptional regulators [Transcription]; Region: COG1695
1247189003856	Transcriptional regulator PadR-like family; Region: PadR; pfam03551
1247189003857	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
1247189003858	E3 interaction surface; other site
1247189003859	lipoyl attachment site [posttranslational modification]; other site
1247189003860	dihydrolipoamide dehydrogenase; Region: lipoamide_DH; TIGR01350
1247189003861	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
1247189003862	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
1247189003863	branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856
1247189003864	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
1247189003865	E3 interaction surface; other site
1247189003866	lipoyl attachment site [posttranslational modification]; other site
1247189003867	e3 binding domain; Region: E3_binding; pfam02817
1247189003868	e3 binding domain; Region: E3_binding; pfam02817
1247189003869	2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198
1247189003870	Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022
1247189003871	Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036
1247189003872	alpha subunit interface [polypeptide binding]; other site
1247189003873	TPP binding site [chemical binding]; other site
1247189003874	heterodimer interface [polypeptide binding]; other site
1247189003875	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
1247189003876	Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, alpha subunit [Energy production and conversion]; Region: AcoA; COG1071
1247189003877	Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000
1247189003878	tetramer interface [polypeptide binding]; other site
1247189003879	TPP-binding site [chemical binding]; other site
1247189003880	heterodimer interface [polypeptide binding]; other site
1247189003881	phosphorylation loop region [posttranslational modification]
1247189003882	ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488
1247189003883	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
1247189003884	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
1247189003885	ABC transporter; Region: ABC_tran_2; pfam12848
1247189003886	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
1247189003887	Predicted esterase [General function prediction only]; Region: COG0627
1247189003888	S-formylglutathione hydrolase; Region: PLN02442
1247189003889	mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595
1247189003890	Metallo-beta-lactamase superfamily; Region: Lactamase_B; pfam00753
1247189003891	RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521
1247189003892	ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: PhnK; COG1101
1247189003893	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1247189003894	Walker A/P-loop; other site
1247189003895	ATP binding site [chemical binding]; other site
1247189003896	Q-loop/lid; other site
1247189003897	ABC transporter signature motif; other site
1247189003898	Walker B; other site
1247189003899	D-loop; other site
1247189003900	H-loop/switch region; other site
1247189003901	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
1247189003902	Transmembrane subunit (TM) of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which are involved in the uptake of branched-chain amino acids (AAs), as well as TMs of transporters involved in the uptake of...; Region: TM_PBP1_branched-chain-AA_like; cd06574
1247189003903	TM-ABC transporter signature motif; other site
1247189003904	Type I periplasmic ligand-binding domain of uncharacterized ABC-type transport systems that are predicted to be involved in the uptake of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_uncharacterized_transporter; cd06325
1247189003905	zinc binding site [ion binding]; other site
1247189003906	putative ligand binding site [chemical binding]; other site
1247189003907	Uncharacterized protein family (UPF0236); Region: UPF0236; pfam06782
1247189003908	acid phosphatase/phosphotransferase; Provisional; Region: aphA; PRK11009
1247189003909	Transposase; Region: HTH_Tnp_1; pfam01527
1247189003910	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963
1247189003911	HTH-like domain; Region: HTH_21; pfam13276
1247189003912	Integrase core domain; Region: rve; pfam00665
1247189003913	Integrase core domain; Region: rve_3; pfam13683
1247189003914	glucans biosynthesis protein; Provisional; Region: opgC; PRK03854
1247189003915	Predicted RNA-binding protein homologous to eukaryotic snRNP [Transcription]; Region: COG1293
1247189003916	Domain of unknown function (DUF814); Region: DUF814; pfam05670
1247189003917	type IV pilus biogenesis/stability protein PilW; Region: type_IV_pilW; TIGR02521
1247189003918	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
1247189003919	binding surface
1247189003920	TPR motif; other site
1247189003921	Anaphase-promoting complex, cyclosome, subunit 3; Region: Apc3; pfam12895
1247189003922	Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628
1247189003923	Domain of unknown function DUF20; Region: UPF0118; pfam01594
1247189003924	MutT homolog-1 (MTH1) is a member of the Nudix hydrolase superfamily. MTH1, the mammalian counterpart of MutT, hydrolyzes oxidized purine nucleoside triphosphates, such as 8-oxo-dGTP and 2-hydroxy-ATP, to monophosphates, thereby preventing the...; Region: MTH1; cd03427
1247189003925	putative active site [active]
1247189003926	nucleotide binding site [chemical binding]; other site
1247189003927	nudix motif; other site
1247189003928	putative metal binding site [ion binding]; other site
1247189003929	Myosin and Kinesin motor domain. These ATPases belong to the P-loop NTPase family and provide the driving force in myosin and kinesin mediated processes; Region: Motor_domain; cl00286
1247189003930	CAAX protease self-immunity; Region: Abi; pfam02517
1247189003931	dTDP-D-glucose 4,6-dehydratase [Cell envelope biogenesis, outer membrane]; Region: RfbB; COG1088
1247189003932	dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246
1247189003933	NAD binding site [chemical binding]; other site
1247189003934	substrate binding site [chemical binding]; other site
1247189003935	homodimer interface [polypeptide binding]; other site
1247189003936	active site
1247189003937	dTDP-4-dehydrorhamnose 3,5-epimerase and related enzymes [Cell envelope biogenesis, outer membrane]; Region: RfbC; COG1898
1247189003938	dTDP-4-dehydrorhamnose 3,5-epimerase and related enzymes [Cell envelope biogenesis, outer membrane]; Region: RfbC; COG1898
1247189003939	G1P_TT_short is the short form of glucose-1-phosphate thymidylyltransferase; Region: G1P_TT_short; cd02538
1247189003940	glucose-1-phosphate thymidylyltransferase, short form; Region: rmlA; TIGR01207
1247189003941	substrate binding site; other site
1247189003942	tetramer interface; other site
1247189003943	Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665
1247189003944	NAD-dependent, lactate dehydrogenase-like, 2-hydroxycarboxylate dehydrogenase family; Region: LDH_MDH_like; cl17195
1247189003945	Predicted divalent heavy-metal cations transporter [Inorganic ion transport and metabolism]; Region: COG0428
1247189003946	Uncharacterized conserved protein [Function unknown]; Region: COG0327
1247189003947	NIF3 (NGG1p interacting factor 3); Region: NIF3; pfam01784
1247189003948	Predicted SAM-dependent methyltransferase [General function prediction only]; Region: COG2384
1247189003949	Family of unknown function (DUF633); Region: DUF633; pfam04816
1247189003950	Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177
1247189003951	Domain of unknown function (DU1801); Region: DUF1801; cl17490
1247189003952	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056
1247189003953	minor groove reading motif; other site
1247189003954	helix-hairpin-helix signature motif; other site
1247189003955	substrate binding pocket [chemical binding]; other site
1247189003956	active site
1247189003957	Putative primosome component and related proteins [DNA replication, recombination, and repair]; Region: DnaD; COG3935
1247189003958	Replication initiation and membrane attachment; Region: DnaB_2; pfam07261
1247189003959	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
1247189003960	active site
1247189003961	Single-strand DNA-specific exonuclease, C terminal domain; Region: ssDNA-exonuc_C; cl11538
1247189003962	Single-strand DNA-specific exonuclease, C terminal domain; Region: ssDNA-exonuc_C; cl11538
1247189003963	single-stranded-DNA-specific exonuclease RecJ; Region: recJ; TIGR00644
1247189003964	DHH family; Region: DHH; pfam01368
1247189003965	Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300
1247189003966	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
1247189003967	NAD(P) binding site [chemical binding]; other site
1247189003968	active site
1247189003969	ribonuclease Z; Region: RNase_Z; TIGR02651
1247189003970	Galactose-1-phosphate uridyl transferase, N-terminal domain; Region: GalP_UDP_transf; pfam01087
1247189003971	GTP-binding protein HflX; Region: GTP_HflX; TIGR03156
1247189003972	GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167
1247189003973	HflX GTPase family; Region: HflX; cd01878
1247189003974	G1 box; other site
1247189003975	GTP/Mg2+ binding site [chemical binding]; other site
1247189003976	Switch I region; other site
1247189003977	G2 box; other site
1247189003978	G3 box; other site
1247189003979	Switch II region; other site
1247189003980	G4 box; other site
1247189003981	G5 box; other site
1247189003982	tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324
1247189003983	tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091
1247189003984	C4-dicarboxylate transporters of the Tellurite-resistance/Dicarboxylate Transporter (TDT) family; Region: TDT_C4-dicarb_trans; cd09325
1247189003985	GST_N family, Class Beta subfamily; GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic alkylating agents, including carcinogens; Region: GST_N_Beta; cd03057
1247189003986	C-terminal domain interface [polypeptide binding]; other site
1247189003987	GSH binding site (G-site) [chemical binding]; other site
1247189003988	dimer interface [polypeptide binding]; other site
1247189003989	C-terminal, alpha helical domain of Class Beta Glutathione S-transferases; Region: GST_C_Beta; cd03188
1247189003990	dimer interface [polypeptide binding]; other site
1247189003991	N-terminal domain interface [polypeptide binding]; other site
1247189003992	substrate binding pocket (H-site) [chemical binding]; other site
1247189003993	Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190
1247189003994	active site
1247189003995	Protein of unknown function (DUF3650); Region: DUF3650; pfam12368
1247189003996	putative rhodanese-related sulfurtransferase; Provisional; Region: PRK00142
1247189003997	Member of the Rhodanese Homology Domain superfamily. This CD includes Escherichia coli YceA, Bacillus subtilis YbfQ, and similar uncharacterized proteins; Region: RHOD_YceA; cd01518
1247189003998	active site residue [active]
1247189003999	Stringent starvation protein B; Region: SspB; cl01120
1247189004000	Predicted flavoprotein [General function prediction only]; Region: COG0431
1247189004001	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
1247189004002	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
1247189004003	glycogen/starch/alpha-glucan phosphorylases; Region: P_ylase; TIGR02093
1247189004004	4-alpha-glucanotransferase; Provisional; Region: PRK14508
1247189004005	Transcriptional regulators [Transcription]; Region: PurR; COG1609
1247189004006	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
1247189004007	DNA binding site [nucleotide binding]
1247189004008	domain linker motif; other site
1247189004009	Ligand-binding domain of uncharacterized transcription regulator ycjW which is a member of the LacI-GalR family repressors; Region: PBP1_ycjW_transcription_regulator_like; cd06294
1247189004010	putative dimerization interface [polypeptide binding]; other site
1247189004011	putative ligand binding site [chemical binding]; other site
1247189004012	Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826
1247189004013	Integrase core domain; Region: rve; pfam00665
1247189004014	Helix-turn-helix domain; Region: HTH_38; pfam13936
1247189004015	Maltose-binding periplasmic proteins/domains [Carbohydrate transport and metabolism]; Region: MalE; COG2182
1247189004016	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
1247189004017	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1247189004018	dimer interface [polypeptide binding]; other site
1247189004019	conserved gate region; other site
1247189004020	ABC-ATPase subunit interface; other site
1247189004021	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
1247189004022	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1247189004023	dimer interface [polypeptide binding]; other site
1247189004024	conserved gate region; other site
1247189004025	putative PBP binding loops; other site
1247189004026	ABC-ATPase subunit interface; other site
1247189004027	Transcriptional regulators [Transcription]; Region: PurR; COG1609
1247189004028	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
1247189004029	DNA binding site [nucleotide binding]
1247189004030	domain linker motif; other site
1247189004031	Predicted integral membrane protein [Function unknown]; Region: COG5521
1247189004032	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
1247189004033	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1247189004034	dimer interface [polypeptide binding]; other site
1247189004035	conserved gate region; other site
1247189004036	putative PBP binding loops; other site
1247189004037	ABC-ATPase subunit interface; other site
1247189004038	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1247189004039	dimer interface [polypeptide binding]; other site
1247189004040	conserved gate region; other site
1247189004041	putative PBP binding loops; other site
1247189004042	ABC-ATPase subunit interface; other site
1247189004043	N-terminal Early set domain associated with the catalytic domain of cyclomaltodextrinase and pullulan-degrading enzymes; Region: E_set_CDase_PDE_N; cd02857
1247189004044	maltodextrin glucosidase; Provisional; Region: PRK10785
1247189004045	homodimer interface [polypeptide binding]; other site
1247189004046	Alpha amylase catalytic domain found in cyclomaltodextrinases and related proteins; Region: AmyAc_CMD; cd11338
1247189004047	active site
1247189004048	homodimer interface [polypeptide binding]; other site
1247189004049	catalytic site [active]
1247189004050	Maltose-binding periplasmic proteins/domains [Carbohydrate transport and metabolism]; Region: MalE; COG2182
1247189004051	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
1247189004052	Protein involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein) [Cell envelope biogenesis, outer membrane]; Region: DltD; COG3966
1247189004053	DltD N-terminal region; Region: DltD_N; pfam04915
1247189004054	DltD central region; Region: DltD_M; pfam04918
1247189004055	DltD C-terminal region; Region: DltD_C; pfam04914
1247189004056	D-alanine--poly(phosphoribitol) ligase subunit 2; Validated; Region: PRK05087
1247189004057	MBOAT, membrane-bound O-acyltransferase family; Region: MBOAT; cl00738
1247189004058	MBOAT, membrane-bound O-acyltransferase family; Region: MBOAT; cl00738
1247189004059	D-alanine--poly(phosphoribitol) ligase subunit 1; Provisional; Region: PRK04813
1247189004060	D-alanine:D-alanyl carrier protein ligase (DltA); Region: DltA; cd05945
1247189004061	acyl-activating enzyme (AAE) consensus motif; other site
1247189004062	AMP binding site [chemical binding]; other site
1247189004063	D-Ala-teichoic acid biosynthesis protein; Region: DUF3687; pfam12459
1247189004064	Myosin and Kinesin motor domain. These ATPases belong to the P-loop NTPase family and provide the driving force in myosin and kinesin mediated processes; Region: Motor_domain; cl00286
1247189004065	excinuclease ABC subunit B; Provisional; Region: PRK05298
1247189004066	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
1247189004067	ATP-binding site [chemical binding]; other site
1247189004068	ATP binding site [chemical binding]; other site
1247189004069	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
1247189004070	nucleotide binding region [chemical binding]; other site
1247189004071	ATP-binding site [chemical binding]; other site
1247189004072	Ultra-violet resistance protein B; Region: UvrB; pfam12344
1247189004073	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
1247189004074	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
1247189004075	substrate binding pocket [chemical binding]; other site
1247189004076	membrane-bound complex binding site; other site
1247189004077	hinge residues; other site
1247189004078	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
1247189004079	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
1247189004080	substrate binding pocket [chemical binding]; other site
1247189004081	membrane-bound complex binding site; other site
1247189004082	hinge residues; other site
1247189004083	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1247189004084	dimer interface [polypeptide binding]; other site
1247189004085	conserved gate region; other site
1247189004086	putative PBP binding loops; other site
1247189004087	ABC-ATPase subunit interface; other site
1247189004088	ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126
1247189004089	ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262
1247189004090	Walker A/P-loop; other site
1247189004091	ATP binding site [chemical binding]; other site
1247189004092	Q-loop/lid; other site
1247189004093	ABC transporter signature motif; other site
1247189004094	Walker B; other site
1247189004095	D-loop; other site
1247189004096	H-loop/switch region; other site
1247189004097	Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455
1247189004098	cellobiose phosphotransferase system IIC component; Reviewed; Region: celD; PRK09592
1247189004099	START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cd07812
1247189004100	hydrophobic ligand binding site; other site
1247189004101	PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_lac; cd00215
1247189004102	active site
1247189004103	methionine cluster; other site
1247189004104	phosphorylation site [posttranslational modification]
1247189004105	metal binding site [ion binding]; metal-binding site
1247189004106	PTS_IIB_chitobiose_lichenan: subunit IIB of enzyme II (EII) of the N,N-diacetylchitobiose-specific and lichenan-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In these systems, EII is either a lichenan- or an N; Region: PTS_IIB_chitobiose_lichenan; cd05564
1247189004107	active site
1247189004108	P-loop; other site
1247189004109	phosphorylation site [posttranslational modification]
1247189004110	Transcriptional antiterminator [Transcription]; Region: BglG; COG3711
1247189004111	HTH domain; Region: HTH_11; pfam08279
1247189004112	Mga helix-turn-helix domain; Region: Mga; pfam05043
1247189004113	PRD domain; Region: PRD; pfam00874
1247189004114	PRD domain; Region: PRD; pfam00874
1247189004115	PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568
1247189004116	active site
1247189004117	P-loop; other site
1247189004118	phosphorylation site [posttranslational modification]
1247189004119	Phosphotransferase system mannitol/fructose-specific IIA domain (Ntr-type) [Carbohydrate transport and metabolism / Signal transduction mechanisms]; Region: PtsN; COG1762
1247189004120	active site
1247189004121	phosphorylation site [posttranslational modification]
1247189004122	Uncharacterized conserved protein [Function unknown]; Region: COG3589
1247189004123	Bacterial protein of unknown function (DUF871); Region: DUF871; pfam05913
1247189004124	Beta-glucosidase/6-phospho-beta-glucosidase/beta- galactosidase [Carbohydrate transport and metabolism]; Region: BglB; COG2723
1247189004125	beta-galactosidase; Region: BGL; TIGR03356
1247189004126	Nicotinamide mononucleotide transporter; Region: NMN_transporter; cl01256
1247189004127	GTPase CgtA; Reviewed; Region: obgE; PRK12297
1247189004128	GTP1/OBG; Region: GTP1_OBG; pfam01018
1247189004129	Obg GTPase; Region: Obg; cd01898
1247189004130	G1 box; other site
1247189004131	GTP/Mg2+ binding site [chemical binding]; other site
1247189004132	Switch I region; other site
1247189004133	G2 box; other site
1247189004134	G3 box; other site
1247189004135	Switch II region; other site
1247189004136	G4 box; other site
1247189004137	G5 box; other site
1247189004138	Domain of unknown function (DUF1967); Region: DUF1967; pfam09269
1247189004139	Thermophilic metalloprotease (M29); Region: Peptidase_M29; pfam02073
1247189004140	Leucyl aminopeptidase (aminopeptidase T) [Amino acid transport and metabolism]; Region: AmpS; COG2309
1247189004141	uncharacterized bacterial subfamily of the Escherichia coli CorA-Salmonella typhimurium ZntB family; Region: EcCorA_ZntB-like_u1; cd12826
1247189004142	CorA-like Mg2+ transporter protein; Region: CorA; pfam01544
1247189004143	Cl binding site [ion binding]; other site
1247189004144	oligomer interface [polypeptide binding]; other site
1247189004145	16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187
1247189004146	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
1247189004147	RNA binding surface [nucleotide binding]; other site
1247189004148	Pseudouridine synthase, Escherichia coli RsuA like; Region: PseudoU_synth_RsuA; cd02553
1247189004149	active site
1247189004150	uracil binding [chemical binding]; other site
1247189004151	Predicted thioesterase [General function prediction only]; Region: COG5496
1247189004152	benzoate transport; Region: 2A0115; TIGR00895
1247189004153	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1247189004154	putative substrate translocation pore; other site
1247189004155	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4868
1247189004156	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4868
1247189004157	ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG0390
1247189004158	ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: COG4619
1247189004159	ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260
1247189004160	Walker A/P-loop; other site
1247189004161	ATP binding site [chemical binding]; other site
1247189004162	Q-loop/lid; other site
1247189004163	ABC transporter signature motif; other site
1247189004164	Walker B; other site
1247189004165	D-loop; other site
1247189004166	H-loop/switch region; other site
1247189004167	PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria.  Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443
1247189004168	CoenzymeA binding site [chemical binding]; other site
1247189004169	subunit interaction site [polypeptide binding]; other site
1247189004170	PHB binding site; other site
1247189004171	Phosphorylase superfamily; Region: PNP_UDP_1; pfam01048
1247189004172	Phosphorylase superfamily; Region: PNP_UDP_1; cl00303
1247189004173	NLPA lipoprotein; Region: Lipoprotein_9; pfam03180
1247189004174	Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961
1247189004175	Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338
1247189004176	catalytic residues [active]
1247189004177	catalytic nucleophile [active]
1247189004178	Recombinase; Region: Recombinase; pfam07508
1247189004179	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963
1247189004180	Transposase; Region: HTH_Tnp_1; pfam01527
1247189004181	HTH-like domain; Region: HTH_21; pfam13276
1247189004182	Integrase core domain; Region: rve; pfam00665
1247189004183	DDE domain; Region: DDE_Tnp_IS240; pfam13610
1247189004184	Integrase core domain; Region: rve_3; pfam13683
1247189004185	Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961
1247189004186	Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338
1247189004187	catalytic residues [active]
1247189004188	catalytic nucleophile [active]
1247189004189	Recombinase; Region: Recombinase; pfam07508
1247189004190	Recombinase zinc beta ribbon domain; Region: Zn_ribbon_recom; pfam13408
1247189004191	Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420
1247189004192	Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420
1247189004193	N-6 DNA Methylase; Region: N6_Mtase; pfam02384
1247189004194	Methyltransferase domain; Region: Methyltransf_26; pfam13659
1247189004195	Relaxase/Mobilisation nuclease domain; Region: Relaxase; pfam03432
1247189004196	Ribbon-helix-helix protein, copG family; Region: RHH_1; pfam01402
1247189004197	phage/plasmid primase, P4 family, C-terminal domain; Region: primase_Cterm; TIGR01613
1247189004198	Poxvirus D5 protein-like; Region: Pox_D5; pfam03288
1247189004199	SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase [Translation, ribosomal structure and biogenesis]; Region: TrmA; COG2265
1247189004200	TRAM domain; Region: TRAM; pfam01938
1247189004201	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1247189004202	S-adenosylmethionine binding site [chemical binding]; other site
1247189004203	Transcriptional regulator [Transcription]; Region: LytR; COG1316
1247189004204	shikimate kinase; Reviewed; Region: aroK; PRK00131
1247189004205	Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464
1247189004206	ADP binding site [chemical binding]; other site
1247189004207	magnesium binding site [ion binding]; other site
1247189004208	putative shikimate binding site; other site
1247189004209	3-phosphoshikimate 1-carboxyvinyltransferase; Provisional; Region: PRK02427
1247189004210	EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556
1247189004211	hinge; other site
1247189004212	active site
1247189004213	Ribonuclease BN family enzyme [Replication, recombination, and repair]; Region: Rbn; COG1295
1247189004214	Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086
1247189004215	active site
1247189004216	The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509
1247189004217	active site 2 [active]
1247189004218	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
1247189004219	DNA-binding site [nucleotide binding]; DNA binding site
1247189004220	DRTGG domain; Region: DRTGG; pfam07085
1247189004221	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with a DRTGG domain upstream. The function of the DRTGG domain, named after its conserved residues, is unknown. CBS is a small domain originally...; Region: CBS_pair_DRTGG_assoc; cd04596
1247189004222	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
1247189004223	Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583
1247189004224	YSIRK type signal peptide; Region: YSIRK_signal; cl04650
1247189004225	GA module; Region: GA; cl08325
1247189004226	GA module; Region: GA; pfam01468
1247189004227	GA module; Region: GA; pfam01468
1247189004228	B domain; Region: IgG_binding_B; pfam01378
1247189004229	B domain; Region: IgG_binding_B; pfam01378
1247189004230	Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472
1247189004231	Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; cl07971
1247189004232	Predicted phosphatases [General function prediction only]; Region: Gph; COG0546
1247189004233	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
1247189004234	motif II; other site
1247189004235	D-mannonate oxidoreductase; Provisional; Region: PRK08277
1247189004236	putative D-mannonate oxidoreductase, classical (c) SDR; Region: mannonate_red_SDR_c; cd08935
1247189004237	putative NAD(P) binding site [chemical binding]; other site
1247189004238	active site
1247189004239	mannonate dehydratase; Provisional; Region: PRK03906
1247189004240	mannonate dehydratase; Region: uxuA; TIGR00695
1247189004241	Glucuronate isomerase; Region: UxaC; pfam02614
1247189004242	Glucuronate isomerase [Carbohydrate transport and metabolism]; Region: UxaC; COG1904
1247189004243	2-keto-3-deoxy-6-phosphogluconate aldolase [Carbohydrate transport and metabolism]; Region: Eda; COG0800
1247189004244	KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452
1247189004245	active site
1247189004246	intersubunit interface [polypeptide binding]; other site
1247189004247	catalytic residue [active]
1247189004248	Transcriptional regulators [Transcription]; Region: FadR; COG2186
1247189004249	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
1247189004250	DNA-binding site [nucleotide binding]; DNA binding site
1247189004251	FCD domain; Region: FCD; pfam07729
1247189004252	beta-D-glucuronidase; Provisional; Region: PRK10150
1247189004253	Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837
1247189004254	Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703
1247189004255	Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836
1247189004256	2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166
1247189004257	Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524
1247189004258	substrate binding site [chemical binding]; other site
1247189004259	ATP binding site [chemical binding]; other site
1247189004260	MFS/sugar transport protein; Region: MFS_2; pfam13347
1247189004261	melibiose:sodium symporter; Provisional; Region: PRK10429; cl15392
1247189004262	UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072
1247189004263	UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555
1247189004264	hinge; other site
1247189004265	active site
1247189004266	S-adenosylmethionine synthetase; Validated; Region: PRK05250
1247189004267	S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438
1247189004268	S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772
1247189004269	S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773
1247189004270	streptococcal histidine triad protein; Region: strep_his_triad; TIGR01363
1247189004271	Streptococcal histidine triad protein; Region: Strep_his_triad; pfam04270
1247189004272	Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799
1247189004273	Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond...; Region: LRR_RI; cl15309
1247189004274	Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799
1247189004275	Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799
1247189004276	Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799
1247189004277	Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799
1247189004278	Biotin operon repressor [Transcription]; Region: BirA; COG1654
1247189004279	bifunctional biotin--[acetyl-CoA-carboxylase] synthetase/biotin operon repressor; Provisional; Region: PRK11886
1247189004280	Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; pfam03099
1247189004281	Biotin protein ligase C terminal domain; Region: BPL_C; pfam02237
1247189004282	DNA polymerase III subunits gamma and tau; Validated; Region: PRK05563
1247189004283	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1247189004284	Walker A motif; other site
1247189004285	ATP binding site [chemical binding]; other site
1247189004286	Walker B motif; other site
1247189004287	arginine finger; other site
1247189004288	DNA polymerase III subunits gamma and tau domain III; Region: DNA_pol3_gamma3; pfam12169
1247189004289	GAF domain-containing protein [Signal transduction mechanisms]; Region: COG1956
1247189004290	Membrane proteinase, regulator of anti-sigma factor [Posttranslational modification, protein turnover, chaperones]; Region: prsW; COG2339
1247189004291	Protein of unknown function (DUF1294); Region: DUF1294; pfam06961
1247189004292	Uridine kinase [Nucleotide transport and metabolism]; Region: Udk; COG0572
1247189004293	Uridine monophosphate kinase (UMPK, EC 2.7.1.48), also known as uridine kinase or uridine-cytidine kinase (UCK), catalyzes the reversible phosphoryl transfer from ATP to uridine or cytidine to yield UMP or CMP. In the primidine nucleotide-salvage pathway; Region: UMPK; cd02023
1247189004294	Sugar specificity; other site
1247189004295	Pyrimidine base specificity; other site
1247189004296	ATP-binding site [chemical binding]; other site
1247189004297	Superfamily II DNA and RNA helicases [DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis]; Region: SrmB; COG0513
1247189004298	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251
1247189004299	ATP binding site [chemical binding]; other site
1247189004300	putative Mg++ binding site [ion binding]; other site
1247189004301	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
1247189004302	nucleotide binding region [chemical binding]; other site
1247189004303	ATP-binding site [chemical binding]; other site
1247189004304	delta-lactam-biosynthetic de-N-acetylase; Region: spore_pdaA; TIGR02884
1247189004305	Catalytic NodB homology domain of Streptococcus pneumoniae peptidoglycan deacetylase PgdA, Bacillus subtilis BsYjeA protein, and their bacterial homologs; Region: CE4_SpPgdA_BsYjeA_like; cd10947
1247189004306	NodB motif; other site
1247189004307	active site
1247189004308	catalytic site [active]
1247189004309	Zn binding site [ion binding]; other site
1247189004310	NADP+-dependent non-phosphorylating glyceraldehyde 3-phosphate dehydrogenase and ALDH family 11; Region: ALDH_F11_NP-GAPDH; cd07082
1247189004311	NADP-dependent glyceraldehyde-3-phosphate dehydrogenase; Provisional; Region: PLN00412
1247189004312	tetrameric interface [polypeptide binding]; other site
1247189004313	activator binding site; other site
1247189004314	NADP binding site [chemical binding]; other site
1247189004315	substrate binding site [chemical binding]; other site
1247189004316	catalytic residues [active]
1247189004317	Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism]; Region: PtsA; COG1080
1247189004318	PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524
1247189004319	PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391
1247189004320	PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896
1247189004321	Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367
1247189004322	dimerization domain swap beta strand [polypeptide binding]; other site
1247189004323	regulatory protein interface [polypeptide binding]; other site
1247189004324	active site
1247189004325	regulatory phosphorylation site [posttranslational modification]; other site
1247189004326	NrdH-redoxin (NrdH) family; NrdH is a small monomeric protein with a conserved redox active CXXC motif within a TRX fold, characterized by a glutaredoxin (GRX)-like sequence and TRX-like activity profile. In vitro, it displays protein disulfide reductase...; Region: NrdH; cd02976
1247189004327	catalytic residues [active]
1247189004328	ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK07306
1247189004329	Ribonucleotide reductase N-terminal; Region: RNR_N; pfam08343
1247189004330	Class I ribonucleotide reductase; Region: RNR_I; cd01679
1247189004331	active site
1247189004332	dimer interface [polypeptide binding]; other site
1247189004333	catalytic residues [active]
1247189004334	effector binding site; other site
1247189004335	R2 peptide binding site; other site
1247189004336	ribonucleotide-diphosphate reductase subunit beta; Provisional; Region: nrdF2; PRK13966
1247189004337	Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049
1247189004338	dimer interface [polypeptide binding]; other site
1247189004339	putative radical transfer pathway; other site
1247189004340	diiron center [ion binding]; other site
1247189004341	tyrosyl radical; other site
1247189004342	Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038
1247189004343	Putative ClC chloride channel.  Clc proteins are putative halogen ion (Cl-, Br- and I-) transporters found in eubacteria. They belong to the ClC superfamily of halogen ion channels, which share a unique double-barreled architecture and voltage-dependent...; Region: ClC_like; cd01033
1247189004344	putative ion selectivity filter; other site
1247189004345	putative pore gating glutamate residue; other site
1247189004346	CAAX protease self-immunity; Region: Abi; pfam02517
1247189004347	Protein of unknown function (DUF3169); Region: DUF3169; pfam11368
1247189004348	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
1247189004349	non-specific DNA binding site [nucleotide binding]; other site
1247189004350	salt bridge; other site
1247189004351	sequence-specific DNA binding site [nucleotide binding]; other site
1247189004352	Protein of unknown function (DUF3267); Region: DUF3267; pfam11667
1247189004353	alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252
1247189004354	Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673
1247189004355	motif 1; other site
1247189004356	active site
1247189004357	motif 2; other site
1247189004358	motif 3; other site
1247189004359	Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863
1247189004360	DHHA1 domain; Region: DHHA1; pfam02272
1247189004361	foldase protein PrsA; Reviewed; Region: prsA; PRK01326
1247189004362	GH3 auxin-responsive promoter; Region: GH3; pfam03321
1247189004363	PPIC-type PPIASE domain; Region: Rotamase_2; cl08278
1247189004364	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; pfam13808
1247189004365	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
1247189004366	Transposase [DNA replication, recombination, and repair]; Region: COG5433
1247189004367	Predicted O-methyltransferase [General function prediction only]; Region: COG4122
1247189004368	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1247189004369	S-adenosylmethionine binding site [chemical binding]; other site
1247189004370	oxalate/formate antiporter family transporter; Region: 2A0111; TIGR00890
1247189004371	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1247189004372	putative substrate translocation pore; other site
1247189004373	Predicted phosphatases [General function prediction only]; Region: Gph; COG0546
1247189004374	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
1247189004375	motif II; other site
1247189004376	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
1247189004377	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
1247189004378	Coenzyme A binding pocket [chemical binding]; other site
1247189004379	Predicted flavoprotein [General function prediction only]; Region: COG0431
1247189004380	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
1247189004381	Oligoendopeptidase F [Amino acid transport and metabolism]; Region: COG1164
1247189004382	Peptidase family M3B Oligopeptidase F (PepF); Region: M3B_PepF_3; cd09608
1247189004383	active site
1247189004384	Zn binding site [ion binding]; other site
1247189004385	Competence protein CoiA-like family; Region: CoiA; cl11541
1247189004386	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1247189004387	putative substrate translocation pore; other site
1247189004388	Major Facilitator Superfamily; Region: MFS_1; pfam07690
1247189004389	Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to pseudouridines (5-ribosyluracil, psi); Region: PseudoU_synth; cl00130
1247189004390	16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187
1247189004391	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
1247189004392	RNA binding surface [nucleotide binding]; other site
1247189004393	Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to pseudouridines (5-ribosyluracil, psi); Region: PseudoU_synth; cl00130
1247189004394	active site
1247189004395	6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363
1247189004396	GlcN6P_deaminase: Glucosamine-6-phosphate (GlcN6P) deaminase subfamily; GlcN6P deaminase catalyzes the reversible conversion of GlcN6P to D-fructose-6-phosphate (Fru6P) and ammonium. The reaction is an aldo-keto isomerization coupled with an amination or...; Region: GlcN6P_deaminase; cd01399
1247189004397	active site
1247189004398	trimer interface [polypeptide binding]; other site
1247189004399	allosteric site; other site
1247189004400	active site lid [active]
1247189004401	hexamer (dimer of trimers) interface [polypeptide binding]; other site
1247189004402	S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Provisional; Region: queA; PRK00147
1247189004403	S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Region: queA; TIGR00113
1247189004404	Protein of unknown function (DUF3114); Region: DUF3114; pfam11311
1247189004405	Beta-lactamase enzyme family; Region: Beta-lactamase2; pfam13354
1247189004406	Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605
1247189004407	Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081
1247189004408	Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777
1247189004409	DNA polymerase III subunit delta; Reviewed; Region: holA; PRK05574
1247189004410	DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144
1247189004411	DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144
1247189004412	Predicted membrane metal-binding protein [General function prediction only]; Region: ComEC; COG0658
1247189004413	Domain of unknown function (DUF4131); Region: DUF4131; pfam13567
1247189004414	Competence protein; Region: Competence; pfam03772
1247189004415	Predicted hydrolase (metallo-beta-lactamase superfamily) [General function prediction only]; Region: ComEC; COG2333
1247189004416	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
1247189004417	SLBB domain; Region: SLBB; pfam10531
1247189004418	comEA protein; Region: comE; TIGR01259
1247189004419	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cl14786
1247189004420	1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204
1247189004421	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989
1247189004422	putative acyl-acceptor binding pocket; other site
1247189004423	Predicted O-methyltransferase [General function prediction only]; Region: COG4123
1247189004424	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1247189004425	S-adenosylmethionine binding site [chemical binding]; other site
1247189004426	The GIY-YIG domain of uncharacterized protein family UPF0213 related to structure-specific endonuclease SLX1; Region: GIY-YIG_UPF0213; cd10456
1247189004427	GIY-YIG motif/motif A; other site
1247189004428	putative active site [active]
1247189004429	putative metal binding site [ion binding]; other site
1247189004430	K+ potassium transporter; Region: K_trans; cl15781
1247189004431	helicase 45; Provisional; Region: PTZ00424
1247189004432	DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker  B motif; Region: DEADc; cd00268
1247189004433	ATP binding site [chemical binding]; other site
1247189004434	Mg++ binding site [ion binding]; other site
1247189004435	motif III; other site
1247189004436	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
1247189004437	nucleotide binding region [chemical binding]; other site
1247189004438	ATP-binding site [chemical binding]; other site
1247189004439	ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464
1247189004440	NLPA lipoprotein; Region: Lipoprotein_9; cl17547
1247189004441	ABC-type metal ion transport system, permease component [Inorganic ion transport and metabolism]; Region: AbcD; COG2011
1247189004442	dimer interface [polypeptide binding]; other site
1247189004443	conserved gate region; other site
1247189004444	putative PBP binding loops; other site
1247189004445	ABC-ATPase subunit interface; other site
1247189004446	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
1247189004447	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1247189004448	Walker A/P-loop; other site
1247189004449	ATP binding site [chemical binding]; other site
1247189004450	Q-loop/lid; other site
1247189004451	ABC transporter signature motif; other site
1247189004452	Walker B; other site
1247189004453	D-loop; other site
1247189004454	H-loop/switch region; other site
1247189004455	Pleckstrin homology (PH)-like domains in bacteria (PHb); Region: PH-like_bacteria; cd13225
1247189004456	pentamer interface [polypeptide binding]; other site
1247189004457	dodecaamer interface [polypeptide binding]; other site
1247189004458	peptide chain release factor 3; Provisional; Region: prfC; PRK00741
1247189004459	Release Factor 3 (RF3) protein involved in the terminal step of translocation in bacteria; Region: RF3; cd04169
1247189004460	G1 box; other site
1247189004461	putative GEF interaction site [polypeptide binding]; other site
1247189004462	GTP/Mg2+ binding site [chemical binding]; other site
1247189004463	Switch I region; other site
1247189004464	G2 box; other site
1247189004465	G3 box; other site
1247189004466	Switch II region; other site
1247189004467	G4 box; other site
1247189004468	G5 box; other site
1247189004469	RF3_II: this subfamily represents the domain II of bacterial Release Factor 3 (RF3). Termination of protein synthesis by the ribosome requires two release factor (RF) classes. The class II RF3 is a GTPase that removes class I RFs (RF1 or RF2) from the...; Region: RF3_II; cd03689
1247189004470	conserved hypothetical integral membrane protein TIGR02206; Region: intg_mem_TP0381
1247189004471	UDP-N-acetylmuramyl pentapeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurF; COG0770
1247189004472	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
1247189004473	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
1247189004474	UDP-N-acetylmuramyl pentapeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurF; COG0770
1247189004475	D-alanyl-alanine synthetase A; Reviewed; Region: ddl; PRK01966
1247189004476	D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820
1247189004477	D-ala D-ala ligase C-terminus; Region: Dala_Dala_lig_C; pfam07478
1247189004478	recombination protein RecR; Reviewed; Region: recR; PRK00076
1247189004479	RecR protein; Region: RecR; pfam02132
1247189004480	TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR.  RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025
1247189004481	putative active site [active]
1247189004482	putative metal-binding site [ion binding]; other site
1247189004483	tetramer interface [polypeptide binding]; other site
1247189004484	Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768
1247189004485	Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717
1247189004486	Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717
1247189004487	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905
1247189004488	Formate/nitrite family of transporters [Inorganic ion transport and metabolism]; Region: FocA; COG2116
1247189004489	Predicted small molecule binding protein (contains 3H domain) [General function prediction only]; Region: COG1827
1247189004490	HTH domain; Region: HTH_11; pfam08279
1247189004491	3H domain; Region: 3H; pfam02829
1247189004492	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
1247189004493	catalytic core [active]
1247189004494	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
1247189004495	dihydroorotate dehydrogenase (subfamily 1) family protein; Region: pyrD_sub1_fam; TIGR01037
1247189004496	Dihydroorotate dehydrogenase (DHOD) class 1A FMN-binding domain. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine...; Region: DHOD_1A_like; cd04741
1247189004497	active site
1247189004498	FMN binding site [chemical binding]; other site
1247189004499	substrate binding site [chemical binding]; other site
1247189004500	catalytic residues [active]
1247189004501	homodimer interface [polypeptide binding]; other site
1247189004502	heavy metal-(Cd/Co/Hg/Pb/Zn)-translocating P-type ATPase; Region: ATPase-IB2_Cd; TIGR01512
1247189004503	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
1247189004504	Soluble P-type ATPase [General function prediction only]; Region: COG4087
1247189004505	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
1247189004506	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
1247189004507	non-specific DNA binding site [nucleotide binding]; other site
1247189004508	salt bridge; other site
1247189004509	sequence-specific DNA binding site [nucleotide binding]; other site
1247189004510	transcriptional activator, Rgg/GadR/MutR family, C-terminal domain; Region: RGG_Cterm; TIGR01716
1247189004511	H+ Antiporter protein; Region: 2A0121; TIGR00900
1247189004512	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1247189004513	Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591
1247189004514	IHF dimer interface [polypeptide binding]; other site
1247189004515	IHF - DNA interface [nucleotide binding]; other site
1247189004516	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4698
1247189004517	Members of the SGNH-hydrolase superfamily, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase_YpmR_like; cd04506
1247189004518	active site
1247189004519	catalytic triad [active]
1247189004520	oxyanion hole [active]
1247189004521	EDD domain protein, DegV family; Region: DegV; TIGR00762
1247189004522	Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645
1247189004523	LPXTG-motif cell wall anchor domain; Region: LPXTG_anchor; TIGR01167
1247189004524	ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: RecN; COG0497
1247189004525	ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241
1247189004526	ABC transporter signature motif; other site
1247189004527	Walker B; other site
1247189004528	D-loop; other site
1247189004529	H-loop/switch region; other site
1247189004530	ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: RecN; COG0497
1247189004531	ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241
1247189004532	Walker A/P-loop; other site
1247189004533	ATP binding site [chemical binding]; other site
1247189004534	Q-loop/lid; other site
1247189004535	Arginine repressor, DNA binding domain; Region: Arg_repressor; pfam01316
1247189004536	Predicted rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: COG1189
1247189004537	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
1247189004538	RNA binding surface [nucleotide binding]; other site
1247189004539	FtsJ-like methyltransferase; Region: FtsJ; pfam01728
1247189004540	Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142
1247189004541	Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685
1247189004542	substrate binding pocket [chemical binding]; other site
1247189004543	chain length determination region; other site
1247189004544	substrate-Mg2+ binding site; other site
1247189004545	catalytic residues [active]
1247189004546	aspartate-rich region 1; other site
1247189004547	active site lid residues [active]
1247189004548	aspartate-rich region 2; other site
1247189004549	exodeoxyribonuclease VII small subunit; Provisional; Region: PRK00977
1247189004550	Exonuclease VII, large subunit [DNA replication, recombination, and repair]; Region: XseA; COG1570
1247189004551	ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489
1247189004552	generic binding surface II; other site
1247189004553	generic binding surface I; other site
1247189004554	B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171
1247189004555	putative substrate binding site [chemical binding]; other site
1247189004556	putative ATP binding site [chemical binding]; other site
1247189004557	bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK14179
1247189004558	Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763
1247189004559	NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080
1247189004560	homodimer interface [polypeptide binding]; other site
1247189004561	NADP binding site [chemical binding]; other site
1247189004562	substrate binding site [chemical binding]; other site
1247189004563	The alpha-D-phosphohexomutase superfamily includes several related enzymes that catalyze a reversible intramolecular phosphoryl transfer on their sugar substrates. Members of this family include the phosphoglucomutases (PGM1 and PGM2), phosphoglucosamine...; Region: phosphohexomutase; cl03757
1247189004564	active site
1247189004565	substrate binding site [chemical binding]; other site
1247189004566	This CD includes PGM2 (phosphoglucomutase 2) and PGM2L1 (phosphoglucomutase 2-like 1). The mammalian PGM2 is thought to be a phosphopentomutase that catalyzes the conversion of the nucleoside breakdown products, ribose-1-phosphate and...; Region: PGM2; cd05799
1247189004567	metal binding site [ion binding]; metal-binding site
1247189004568	Deoxyribodipyrimidine photolyase [DNA replication, recombination, and repair]; Region: PhrB; COG0415
1247189004569	DNA photolyase; Region: DNA_photolyase; pfam00875
1247189004570	Fe2+ transport system protein B [Inorganic ion transport and metabolism]; Region: FeoB; COG0370
1247189004571	Ferrous iron transport protein B (FeoB) family; Region: FeoB; cd01879
1247189004572	G1 box; other site
1247189004573	GTP/Mg2+ binding site [chemical binding]; other site
1247189004574	Switch I region; other site
1247189004575	G2 box; other site
1247189004576	G3 box; other site
1247189004577	Switch II region; other site
1247189004578	G4 box; other site
1247189004579	G5 box; other site
1247189004580	Nucleoside recognition; Region: Gate; pfam07670
1247189004581	Ferrous iron transport protein B C terminus; Region: FeoB_C; pfam07664
1247189004582	Nucleoside recognition; Region: Gate; pfam07670
1247189004583	FeoA domain; Region: FeoA; pfam04023
1247189004584	Fe2+ transport system protein A [Inorganic ion transport and metabolism]; Region: FeoA; COG1918
1247189004585	ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126
1247189004586	ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262
1247189004587	Walker A/P-loop; other site
1247189004588	ATP binding site [chemical binding]; other site
1247189004589	Q-loop/lid; other site
1247189004590	ABC transporter signature motif; other site
1247189004591	Walker B; other site
1247189004592	D-loop; other site
1247189004593	H-loop/switch region; other site
1247189004594	ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215
1247189004595	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1247189004596	dimer interface [polypeptide binding]; other site
1247189004597	conserved gate region; other site
1247189004598	putative PBP binding loops; other site
1247189004599	ABC-ATPase subunit interface; other site
1247189004600	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4703
1247189004601	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1247189004602	ATPases associated with a variety of cellular activities; Region: AAA; smart00382
1247189004603	Walker A motif; other site
1247189004604	ATP binding site [chemical binding]; other site
1247189004605	Walker B motif; other site
1247189004606	arginine finger; other site
1247189004607	UvrB/uvrC motif; Region: UVR; pfam02151
1247189004608	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1247189004609	Walker A motif; other site
1247189004610	ATP binding site [chemical binding]; other site
1247189004611	Walker B motif; other site
1247189004612	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431
1247189004613	Contains a crystal structure of the Nudix hydrolase from Enterococcus faecalis, which has an unknown function. In general, members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes...; Region: Nudix_Hydrolase_25; cd04684
1247189004614	nudix motif; other site
1247189004615	Domain of unknown function (DUF1827); Region: DUF1827; pfam08860
1247189004616	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
1247189004617	active site
1247189004618	KMSKS motif; other site
1247189004619	Anticodon-binding domain of bacterial and eukaryotic mitochondrial isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_BEm; cd07960
1247189004620	tRNA binding surface [nucleotide binding]; other site
1247189004621	anticodon binding site; other site
1247189004622	Anticodon-binding domain of tRNA; Region: Anticodon_1; pfam08264
1247189004623	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
1247189004624	active site
1247189004625	HIGH motif; other site
1247189004626	nucleotide binding site [chemical binding]; other site
1247189004627	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
1247189004628	DivIVA protein; Region: DivIVA; pfam05103
1247189004629	DivIVA domain; Region: DivI1A_domain; TIGR03544
1247189004630	Uncharacterized conserved protein, contains S4-like domain [Function unknown]; Region: COG2302
1247189004631	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
1247189004632	RNA binding surface [nucleotide binding]; other site
1247189004633	YGGT family; Region: YGGT; pfam02325
1247189004634	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1799
1247189004635	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes; Region: PLPDE_III; cl00261
1247189004636	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
1247189004637	catalytic residue [active]
1247189004638	FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes.  FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201
1247189004639	SulA interaction site; other site
1247189004640	Tubulin/FtsZ: Family includes tubulin alpha-, beta-, gamma-, delta-, and epsilon-tubulins as well as FtsZ, all of which are involved in polymer formation. Tubulin is the major component of microtubules, but also exists as a heterodimer and as a curved...; Region: Tubulin_FtsZ; cl10017
1247189004641	nucleotide binding site [chemical binding]; other site
1247189004642	Cell division ATPase FtsA [Cell division and chromosome partitioning]; Region: ftsA; COG0849
1247189004643	Cell division protein FtsA; Region: FtsA; smart00842
1247189004644	Cell division protein FtsA; Region: FtsA; pfam14450
1247189004645	Domain of unknown function (DUF3484); Region: DUF3484; pfam11983
1247189004646	POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478
1247189004647	Cell division protein FtsQ; Region: FtsQ; pfam03799
1247189004648	undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726
1247189004649	MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785
1247189004650	homodimer interface [polypeptide binding]; other site
1247189004651	active site
1247189004652	UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK02472
1247189004653	Alanine dehydrogenase/PNT, C-terminal domain; Region: AlaDh_PNT_C; smart01002
1247189004654	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
1247189004655	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
1247189004656	Transglutaminase-like superfamily; Region: Transglut_core; cl17362
1247189004657	Protein of unknown function (DUF3165); Region: DUF3165; pfam11364
1247189004658	Predicted membrane GTPase involved in stress response [Signal transduction mechanisms]; Region: TypA; COG1217
1247189004659	Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891
1247189004660	G1 box; other site
1247189004661	putative GEF interaction site [polypeptide binding]; other site
1247189004662	GTP/Mg2+ binding site [chemical binding]; other site
1247189004663	Switch I region; other site
1247189004664	G2 box; other site
1247189004665	G3 box; other site
1247189004666	Switch II region; other site
1247189004667	G4 box; other site
1247189004668	G5 box; other site
1247189004669	BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu.  BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691
1247189004670	BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants.  BipA is a highly...; Region: BipA_TypA_C; cd03710
1247189004671	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158
1247189004672	active site residue [active]
1247189004673	ROK family protein (putative glucokinase); Region: ROK_glcA_fam; TIGR00744
1247189004674	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012
1247189004675	nucleotide binding site [chemical binding]; other site
1247189004676	Bacterial protein of unknown function (DUF910); Region: DUF910; pfam06014
1247189004677	DNA-binding ferritin-like protein (oxidative damage protectant) [Inorganic ion transport and metabolism]; Region: Dps; COG0783
1247189004678	DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043
1247189004679	dimerization interface [polypeptide binding]; other site
1247189004680	DPS ferroxidase diiron center [ion binding]; other site
1247189004681	ion pore; other site
1247189004682	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
1247189004683	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
1247189004684	ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254
1247189004685	Walker A/P-loop; other site
1247189004686	ATP binding site [chemical binding]; other site
1247189004687	Q-loop/lid; other site
1247189004688	ABC transporter signature motif; other site
1247189004689	Walker B; other site
1247189004690	D-loop; other site
1247189004691	H-loop/switch region; other site
1247189004692	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
1247189004693	putative multidrug transporter membrane\ATP-binding components; Provisional; Region: PRK10789
1247189004694	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1247189004695	Walker A/P-loop; other site
1247189004696	ATP binding site [chemical binding]; other site
1247189004697	Q-loop/lid; other site
1247189004698	ABC transporter signature motif; other site
1247189004699	Walker B; other site
1247189004700	D-loop; other site
1247189004701	H-loop/switch region; other site
1247189004702	ribosomal RNA large subunit methyltransferase N; Provisional; Region: PRK14455
1247189004703	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
1247189004704	FeS/SAM binding site; other site
1247189004705	Protein of unknown function (DUF1027); Region: DUF1027; cl09961
1247189004706	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
1247189004707	Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702
1247189004708	NAD(P) binding site [chemical binding]; other site
1247189004709	active site
1247189004710	Transposase; Region: DEDD_Tnp_IS110; pfam01548
1247189004711	D-ribose transporter subunit RbsB; Provisional; Region: PRK10653
1247189004712	Periplasmic sugar-binding domain of the thermophilic Thermoanaerobacter tengcongensis ribose binding protein (ttRBP) and its mesophilic homologs; Region: PBP1_ribose_binding; cd06323
1247189004713	ligand binding site [chemical binding]; other site
1247189004714	dimerization interface [polypeptide binding]; other site
1247189004715	Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579
1247189004716	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
1247189004717	TM-ABC transporter signature motif; other site
1247189004718	ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129
1247189004719	First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216
1247189004720	Walker A/P-loop; other site
1247189004721	ATP binding site [chemical binding]; other site
1247189004722	Q-loop/lid; other site
1247189004723	ABC transporter signature motif; other site
1247189004724	Walker B; other site
1247189004725	D-loop; other site
1247189004726	H-loop/switch region; other site
1247189004727	Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215
1247189004728	D-ribose pyranase; Provisional; Region: PRK11797
1247189004729	Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524
1247189004730	Ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This reaction is the first step in the ribose metabolism. It traps ribose within the cell after uptake and also prepares the sugar for use in the synthesis of nucleotides...; Region: ribokinase; cd01174
1247189004731	substrate binding site [chemical binding]; other site
1247189004732	dimer interface [polypeptide binding]; other site
1247189004733	ATP binding site [chemical binding]; other site
1247189004734	Transcriptional regulators [Transcription]; Region: PurR; COG1609
1247189004735	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
1247189004736	DNA binding site [nucleotide binding]
1247189004737	domain linker motif; other site
1247189004738	Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011
1247189004739	Predicted secreted protein containing a PDZ domain [Signal transduction mechanisms]; Region: SdrC; COG3480
1247189004740	PDZ domain, also called DHR (Dlg homologous region) or GLGF (after a conserved sequence motif). Many PDZ domains bind C-terminal polypeptides, though binding to internal (non-C-terminal) polypeptides and even to lipids has been demonstrated; Region: PDZ; cl00117
1247189004741	protein binding site [polypeptide binding]; other site
1247189004742	Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362
1247189004743	phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168
1247189004744	Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163
1247189004745	active site
1247189004746	(T/H)XGH motif; other site
1247189004747	N6-adenine-specific methylase [DNA replication, recombination, and repair]; Region: COG0742
1247189004748	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1247189004749	S-adenosylmethionine binding site [chemical binding]; other site
1247189004750	Asparagine synthetase (aspartate-ammonia ligase) (AsnA) catalyses the conversion of L-aspartate to L-asparagine in the presence of ATP and ammonia.  AsnA is a homodimeric enzyme which is structurally similiar to the catalytic core domain of class II...; Region: AsnA; cd00645
1247189004751	dimer interface [polypeptide binding]; other site
1247189004752	active site
1247189004753	carbamate kinase; Reviewed; Region: PRK12686
1247189004754	AAK_CK: Carbamate kinase (CK) catalyzes both the ATP-phosphorylation of carbamate and carbamoyl phosphate (CP) utilization with the production of ATP from ADP and CP. Both CK (this CD) and nonhomologous CP synthetase synthesize carbamoyl phosphate, an...; Region: AAK_CK; cd04235
1247189004755	putative substrate binding site [chemical binding]; other site
1247189004756	nucleotide binding site [chemical binding]; other site
1247189004757	nucleotide binding site [chemical binding]; other site
1247189004758	homodimer interface [polypeptide binding]; other site
1247189004759	Transposase; Region: DEDD_Tnp_IS110; pfam01548
1247189004760	Transposase; Region: DEDD_Tnp_IS110; pfam01548
1247189004761	hypothetical protein; Provisional; Region: PRK07205
1247189004762	M20 Peptidase Xaa-His dipeptidase (PepV) degrades hydrophobic dipeptides; Region: M20_PepV; cd03888
1247189004763	active site
1247189004764	metal binding site [ion binding]; metal-binding site
1247189004765	Predicted membrane protein [Function unknown]; Region: COG1288
1247189004766	C4-dicarboxylate anaerobic carrier; Region: DcuC; pfam03606
1247189004767	ornithine carbamoyltransferase; Validated; Region: PRK02102
1247189004768	Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729
1247189004769	Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185
1247189004770	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
1247189004771	Coenzyme A binding pocket [chemical binding]; other site
1247189004772	arginine deiminase; Provisional; Region: PRK01388
1247189004773	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
1247189004774	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
1247189004775	ligand binding site [chemical binding]; other site
1247189004776	flexible hinge region; other site
1247189004777	helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092
1247189004778	putative switch regulator; other site
1247189004779	non-specific DNA interactions [nucleotide binding]; other site
1247189004780	DNA binding site [nucleotide binding]
1247189004781	sequence specific DNA binding site [nucleotide binding]; other site
1247189004782	putative cAMP binding site [chemical binding]; other site
1247189004783	Arginine repressor [Transcription]; Region: ArgR; COG1438
1247189004784	Arginine repressor, DNA binding domain; Region: Arg_repressor; pfam01316
1247189004785	Arginine repressor, C-terminal domain; Region: Arg_repressor_C; pfam02863
1247189004786	Solo B3/4 domain (OB-fold DNA/RNA-binding) of Phe-aaRS-beta [General function prediction only]; Region: COG3382
1247189004787	B3/4 domain; Region: B3_4; pfam03483
1247189004788	Uncharacterized protein conserved in bacteria [Function unknown]; Region: MmcQ; COG2315
1247189004789	Predicted signal transduction protein with a C-terminal ATPase domain [Signal transduction mechanisms]; Region: COG2972
1247189004790	Cache domain; Region: Cache_1; pfam02743
1247189004791	HAMP domain; Region: HAMP; pfam00672
1247189004792	Histidine kinase; Region: His_kinase; pfam06580
1247189004793	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1247189004794	ATP binding site [chemical binding]; other site
1247189004795	Mg2+ binding site [ion binding]; other site
1247189004796	G-X-G motif; other site
1247189004797	Response regulator receiver domain; Region: Response_reg; pfam00072
1247189004798	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1247189004799	active site
1247189004800	phosphorylation site [posttranslational modification]
1247189004801	intermolecular recognition site; other site
1247189004802	dimerization interface [polypeptide binding]; other site
1247189004803	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
1247189004804	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1247189004805	Peptide methionine sulfoxide reductase; Region: PMSR; cl00366
1247189004806	Conserved domain frequently associated with peptide methionine sulfoxide reductase [Posttranslational modification, protein turnover, chaperones]; Region: COG0229
1247189004807	SelR domain; Region: SelR; pfam01641
1247189004808	Peptide methionine sulfoxide reductase; Region: PMSR; cl00366
1247189004809	TlpA-like family; composed of  TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966
1247189004810	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
1247189004811	catalytic residues [active]
1247189004812	Cytochrome c biogenesis protein [Posttranslational modification, protein turnover, chaperones]; Region: CcdA; COG0785
1247189004813	Cytochrome C biogenesis protein transmembrane region; Region: DsbD; pfam02683
1247189004814	CorA-like Mg2+ transporter protein; Region: CorA; pfam01544
1247189004815	uncharacterized bacterial subfamily of the Escherichia coli CorA-Salmonella typhimurium ZntB family; Region: EcCorA_ZntB-like_u2; cd12827
1247189004816	Cl binding site [ion binding]; other site
1247189004817	oligomer interface [polypeptide binding]; other site
1247189004818	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
1247189004819	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
1247189004820	Integrase core domain; Region: rve; pfam00665
1247189004821	Integrase core domain; Region: rve_3; cl15866
1247189004822	Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c_3; pfam13589
1247189004823	ATP binding site [chemical binding]; other site
1247189004824	Mg2+ binding site [ion binding]; other site
1247189004825	G-X-G motif; other site
1247189004826	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
1247189004827	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1247189004828	ATP binding site [chemical binding]; other site
1247189004829	Mg2+ binding site [ion binding]; other site
1247189004830	G-X-G motif; other site
1247189004831	Site-specific DNA methylase [DNA replication, recombination, and repair]; Region: Dcm; COG0270
1247189004832	Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315
1247189004833	cofactor binding site; other site
1247189004834	DNA binding site [nucleotide binding]
1247189004835	substrate interaction site [chemical binding]; other site
1247189004836	Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315
1247189004837	Transposase IS200 like; Region: Y1_Tnp; pfam01797
1247189004838	valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729
1247189004839	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
1247189004840	active site
1247189004841	HIGH motif; other site
1247189004842	nucleotide binding site [chemical binding]; other site
1247189004843	Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603
1247189004844	catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817
1247189004845	active site
1247189004846	KMSKS motif; other site
1247189004847	Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962
1247189004848	tRNA binding surface [nucleotide binding]; other site
1247189004849	anticodon binding site; other site
1247189004850	Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458
1247189004851	AAA domain; Region: AAA_18; pfam13238
1247189004852	AAA domain; Region: AAA_17; pfam13207
1247189004853	Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670
1247189004854	Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583
1247189004855	This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_6; cd07242
1247189004856	putative dimer interface [polypeptide binding]; other site
1247189004857	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
1247189004858	ligand binding site [chemical binding]; other site
1247189004859	Zn binding site [ion binding]; other site
1247189004860	hypothetical protein; Provisional; Region: PRK07758
1247189004861	Domain of unknown function (DUF1912); Region: DUF1912; pfam08930
1247189004862	Transcriptional regulators [Transcription]; Region: MarR; COG1846
1247189004863	MarR family; Region: MarR; pfam01047
1247189004864	Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534
1247189004865	Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Streptococcus aureus MepA; Region: MATE_MepA_like; cd13143
1247189004866	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; pfam13808
1247189004867	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
1247189004868	Transposase [DNA replication, recombination, and repair]; Region: COG5433
1247189004869	3-deoxy-7-phosphoheptulonate synthase; Provisional; Region: PRK13397
1247189004870	DAHP synthetase I family; Region: DAHP_synth_1; pfam00793
1247189004871	Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195
1247189004872	active site
1247189004873	dimer interface [polypeptide binding]; other site
1247189004874	metal binding site [ion binding]; metal-binding site
1247189004875	SEC10/PgrA surface exclusion domain; Region: Surf_Exclu_PgrA; TIGR04320
1247189004876	Membrane transport protein; Region: Mem_trans; cl09117
1247189004877	shikimate 5-dehydrogenase; Provisional; Region: PRK12548
1247189004878	Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501
1247189004879	NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065
1247189004880	shikimate binding site; other site
1247189004881	NAD(P) binding site [chemical binding]; other site
1247189004882	Beta-galactosidase/beta-glucuronidase [Carbohydrate transport and metabolism]; Region: LacZ; COG3250
1247189004883	Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836
1247189004884	Beta-galactosidase/beta-glucuronidase [Carbohydrate transport and metabolism]; Region: LacZ; COG3250
1247189004885	Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837
1247189004886	Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703
1247189004887	Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836
1247189004888	Response regulator containing CheY-like receiver domain and AraC-type DNA-binding domain [Signal transduction mechanisms]; Region: COG4753
1247189004889	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1247189004890	active site
1247189004891	phosphorylation site [posttranslational modification]
1247189004892	intermolecular recognition site; other site
1247189004893	dimerization interface [polypeptide binding]; other site
1247189004894	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1247189004895	Predicted signal transduction protein with a C-terminal ATPase domain [Signal transduction mechanisms]; Region: COG2972
1247189004896	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054
1247189004897	Histidine kinase; Region: His_kinase; pfam06580
1247189004898	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1247189004899	ATP binding site [chemical binding]; other site
1247189004900	Mg2+ binding site [ion binding]; other site
1247189004901	G-X-G motif; other site
1247189004902	Protein of unknown function, DUF624; Region: DUF624; cl02369
1247189004903	Protein of unknown function, DUF624; Region: DUF624; cl02369
1247189004904	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
1247189004905	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
1247189004906	Domain of unknown function (DUF3502); Region: DUF3502; pfam12010
1247189004907	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427
1247189004908	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
1247189004909	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
1247189004910	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427
1247189004911	ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209
1247189004912	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1247189004913	putative PBP binding loops; other site
1247189004914	dimer interface [polypeptide binding]; other site
1247189004915	ABC-ATPase subunit interface; other site
1247189004916	Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940
1247189004917	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012
1247189004918	nucleotide binding site [chemical binding]; other site
1247189004919	Putative alpha-1,2-mannosidase [Carbohydrate transport and metabolism]; Region: COG3537
1247189004920	Glycosyl hydrolase family 92; Region: Glyco_hydro_92; pfam07971
1247189004921	Beta-glucosidase/6-phospho-beta-glucosidase/beta- galactosidase [Carbohydrate transport and metabolism]; Region: BglB; COG2723
1247189004922	beta-galactosidase; Region: BGL; TIGR03356
1247189004923	beta-N-acetylglucosaminidase; Region: NAGidase; pfam07555
1247189004924	Transcriptional regulators [Transcription]; Region: FadR; COG2186
1247189004925	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
1247189004926	DNA-binding site [nucleotide binding]; DNA binding site
1247189004927	Transcriptional regulators [Transcription]; Region: PurR; COG1609
1247189004928	Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267
1247189004929	ligand binding site [chemical binding]; other site
1247189004930	dimerization interface [polypeptide binding]; other site
1247189004931	Uncharacterized conserved protein [Function unknown]; Region: COG3538
1247189004932	Protein of unknown function (DUF1237); Region: DUF1237; pfam06824
1247189004933	Alpha-mannosidase [Carbohydrate transport and metabolism]; Region: AMS1; COG0383
1247189004934	N-terminal catalytic domain of SPGH38, a putative alpha-mannosidase of Streptococcus pyogenes, and its prokaryotic homologs; glycoside hydrolase family 38 (GH38); Region: GH38N_AMII_SpGH38_like; cd10814
1247189004935	active site
1247189004936	metal binding site [ion binding]; metal-binding site
1247189004937	homodimer interface [polypeptide binding]; other site
1247189004938	catalytic site [active]
1247189004939	Alpha mannosidase, middle domain; Region: Alpha-mann_mid; smart00872
1247189004940	ParB-like nuclease domain; Region: ParB; smart00470
1247189004941	Acetyltransferase (GNAT) domain; Region: Acetyltransf_4; pfam13420
1247189004942	DM4/DM12 family; Region: DM4_12; cl11657
1247189004943	Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cd00347
1247189004944	luciferase family oxidoreductase, group 1; Region: oxido_grp_1; TIGR03558
1247189004945	Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892
1247189004946	acyl-CoA synthetase; Validated; Region: PRK08316
1247189004947	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
1247189004948	acyl-activating enzyme (AAE) consensus motif; other site
1247189004949	AMP binding site [chemical binding]; other site
1247189004950	active site
1247189004951	CoA binding site [chemical binding]; other site
1247189004952	putative enoyl-[acyl-carrier-protein] reductase II; Region: enACPred_II; TIGR03151
1247189004953	2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730
1247189004954	FMN binding site [chemical binding]; other site
1247189004955	substrate binding site [chemical binding]; other site
1247189004956	putative catalytic residue [active]
1247189004957	acetyl-CoA acetyltransferase; Provisional; Region: PRK09052
1247189004958	Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751
1247189004959	dimer interface [polypeptide binding]; other site
1247189004960	active site
1247189004961	3-hydroxyacyl-CoA dehydrogenase [Lipid metabolism]; Region: FadB; COG1250
1247189004962	3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737
1247189004963	3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725
1247189004964	3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725
1247189004965	Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024
1247189004966	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
1247189004967	substrate binding site [chemical binding]; other site
1247189004968	oxyanion hole (OAH) forming residues; other site
1247189004969	trimer interface [polypeptide binding]; other site
1247189004970	TRAM domain; Region: TRAM; pfam01938
1247189004971	SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase [Translation, ribosomal structure and biogenesis]; Region: TrmA; COG2265
1247189004972	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1247189004973	S-adenosylmethionine binding site [chemical binding]; other site
1247189004974	recombination regulator RecX; Provisional; Region: recX; PRK14135
1247189004975	hypothetical protein; Provisional; Region: PRK13662
1247189004976	Staphylococcal protein of unknown function (DUF960); Region: DUF960; pfam06124
1247189004977	Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826
1247189004978	Helix-turn-helix domain; Region: HTH_38; pfam13936
1247189004979	Integrase core domain; Region: rve; pfam00665
1247189004980	RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY,  is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552
1247189004981	30S subunit binding site; other site
1247189004982	Predicted amidophosphoribosyltransferases [General function prediction only]; Region: ComFC; COG1040
1247189004983	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
1247189004984	active site
1247189004985	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
1247189004986	nucleotide binding region [chemical binding]; other site
1247189004987	ATP-binding site [chemical binding]; other site
1247189004988	DEAD-like helicases superfamily; Region: DEXDc; smart00487
1247189004989	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
1247189004990	ATP binding site [chemical binding]; other site
1247189004991	putative Mg++ binding site [ion binding]; other site
1247189004992	Uncharacterized conserved protein [Function unknown]; Region: COG1739
1247189004993	Uncharacterized protein family UPF0029; Region: UPF0029; pfam01205
1247189004994	Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031
1247189004995	CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561
1247189004996	dimer interface [polypeptide binding]; other site
1247189004997	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1247189004998	catalytic residue [active]
1247189004999	hypothetical protein; Provisional; Region: PRK07252
1247189005000	general stress protein 13; Validated; Region: PRK08059
1247189005001	RNA binding site [nucleotide binding]; other site
1247189005002	haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282
1247189005003	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
1247189005004	active site
1247189005005	motif I; other site
1247189005006	motif II; other site
1247189005007	haloacid dehalogenase-like hydrolase; Region: HAD; cl17202
1247189005008	cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317
1247189005009	active site
1247189005010	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
1247189005011	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1247189005012	active site
1247189005013	phosphorylation site [posttranslational modification]
1247189005014	intermolecular recognition site; other site
1247189005015	dimerization interface [polypeptide binding]; other site
1247189005016	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
1247189005017	DNA binding residues [nucleotide binding]
1247189005018	dimerization interface [polypeptide binding]; other site
1247189005019	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585
1247189005020	Histidine kinase; Region: HisKA_3; pfam07730
1247189005021	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1247189005022	ATP binding site [chemical binding]; other site
1247189005023	Mg2+ binding site [ion binding]; other site
1247189005024	G-X-G motif; other site
1247189005025	Cell wall-active antibiotics response protein (DUF2154); Region: DUF2154; pfam09922
1247189005026	Predicted membrane protein [Function unknown]; Region: COG4758
1247189005027	Cell wall-active antibiotics response protein (DUF2154); Region: DUF2154; pfam09922
1247189005028	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
1247189005029	Catalytic domain of Protein Kinases; Region: PKc; cd00180
1247189005030	active site
1247189005031	ATP binding site [chemical binding]; other site
1247189005032	substrate binding site [chemical binding]; other site
1247189005033	activation loop (A-loop); other site
1247189005034	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2815
1247189005035	PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577
1247189005036	PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577
1247189005037	PASTA domain. This domain is found at the C-termini of several Penicillin-binding proteins (PBPs) and bacterial serine/threonine kinases. It is a small globular fold consisting of 3 beta-sheets and an alpha-helix. The name PASTA is derived from PBP and...; Region: PASTA; cl02768
1247189005038	Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143
1247189005039	active site
1247189005040	16S rRNA methyltransferase B; Provisional; Region: PRK14902
1247189005041	NusB family; Region: NusB; pfam01029
1247189005042	putative RNA binding site [nucleotide binding]; other site
1247189005043	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1247189005044	S-adenosylmethionine binding site [chemical binding]; other site
1247189005045	methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005
1247189005046	Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646
1247189005047	putative active site [active]
1247189005048	substrate binding site [chemical binding]; other site
1247189005049	putative cosubstrate binding site; other site
1247189005050	catalytic site [active]
1247189005051	C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704
1247189005052	substrate binding site [chemical binding]; other site
1247189005053	Primosomal protein N' (replication factor Y) - superfamily II helicase [DNA replication, recombination, and repair]; Region: PriA; COG1198
1247189005054	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
1247189005055	ATP binding site [chemical binding]; other site
1247189005056	putative Mg++ binding site [ion binding]; other site
1247189005057	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
1247189005058	ATP-binding site [chemical binding]; other site
1247189005059	DNA-directed RNA polymerase subunit omega; Reviewed; Region: rpoZ; PRK00392
1247189005060	Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194
1247189005061	Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071
1247189005062	catalytic site [active]
1247189005063	G-X2-G-X-G-K; other site
1247189005064	hypothetical protein; Provisional; Region: PRK00106
1247189005065	hypothetical protein; Provisional; Region: PRK00106
1247189005066	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
1247189005067	Zn2+ binding site [ion binding]; other site
1247189005068	Mg2+ binding site [ion binding]; other site
1247189005069	Transcriptional regulator [Transcription]; Region: LysR; COG0583
1247189005070	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1247189005071	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
1247189005072	dimerization interface [polypeptide binding]; other site
1247189005073	putative acyltransferase; Provisional; Region: PRK05790
1247189005074	Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751
1247189005075	dimer interface [polypeptide binding]; other site
1247189005076	active site
1247189005077	Acyl CoA:acetate/3-ketoacid CoA transferase, alpha subunit [Lipid metabolism]; Region: AtoD; COG1788
1247189005078	3-oxoacid CoA-transferase, B subunit; Region: pcaJ_scoB_fam; TIGR02428
1247189005079	classical (c) SDRs; Region: SDR_c; cd05233
1247189005080	NAD(P) binding site [chemical binding]; other site
1247189005081	active site
1247189005082	H+/gluconate symporter and related permeases [Carbohydrate transport and metabolism / Amino acid transport and metabolism]; Region: GntT; COG2610
1247189005083	S-ribosylhomocysteinase; Provisional; Region: PRK02260
1247189005084	Predicted N6-adenine-specific DNA methylase [DNA replication, recombination, and repair]; Region: COG0116
1247189005085	THUMP domain associated with S-adenosylmethionine-dependent methyltransferases; Region: THUMP_AdoMetMT; cd11715
1247189005086	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173
1247189005087	cell division protein GpsB; Provisional; Region: PRK14127
1247189005088	DivIVA domain; Region: DivI1A_domain; TIGR03544
1247189005089	hypothetical protein; Provisional; Region: PRK13660
1247189005090	Recombination protein U; Region: RecU; cl01314
1247189005091	Holliday junction-specific endonuclease; Reviewed; Region: recU; PRK02234
1247189005092	Membrane carboxypeptidase (penicillin-binding protein) [Cell envelope biogenesis, outer membrane]; Region: MrcB; COG0744
1247189005093	Transglycosylase; Region: Transgly; pfam00912
1247189005094	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760
1247189005095	Peptidase C1B subfamily (MEROPS database nomenclature); composed of eukaryotic bleomycin hydrolases (BH) and bacterial aminopeptidases C (pepC). The proteins of this subfamily contain a large insert relative to the C1A peptidase (papain) subfamily. BH is...; Region: Peptidase_C1B; cd00585
1247189005096	trimer interface [polypeptide binding]; other site
1247189005097	active site
1247189005098	G bulge; other site
1247189005099	NAD synthase [Coenzyme metabolism]; Region: NadE; COG0171
1247189005100	NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553
1247189005101	homodimer interface [polypeptide binding]; other site
1247189005102	NAD binding pocket [chemical binding]; other site
1247189005103	ATP binding pocket [chemical binding]; other site
1247189005104	Mg binding site [ion binding]; other site
1247189005105	active-site loop [active]
1247189005106	nicotinate phosphoribosyltransferase; Validated; Region: PRK09243
1247189005107	Nicotinate phosphoribosyltransferase (NAPRTase), subgroup A. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting, reaction...; Region: NAPRTase_A; cd01570
1247189005108	active site
1247189005109	Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113
1247189005110	thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292
1247189005111	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
1247189005112	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
1247189005113	Protein of unknown function (DUF4059); Region: DUF4059; pfam13268
1247189005114	ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126
1247189005115	ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262
1247189005116	Walker A/P-loop; other site
1247189005117	ATP binding site [chemical binding]; other site
1247189005118	Q-loop/lid; other site
1247189005119	ABC transporter signature motif; other site
1247189005120	Walker B; other site
1247189005121	D-loop; other site
1247189005122	H-loop/switch region; other site
1247189005123	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1247189005124	dimer interface [polypeptide binding]; other site
1247189005125	conserved gate region; other site
1247189005126	putative PBP binding loops; other site
1247189005127	ABC-ATPase subunit interface; other site
1247189005128	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
1247189005129	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
1247189005130	substrate binding pocket [chemical binding]; other site
1247189005131	membrane-bound complex binding site; other site
1247189005132	hinge residues; other site
1247189005133	DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker  B motif; Region: DEADc; cd00268
1247189005134	DEAD-like helicases superfamily; Region: DEXDc; smart00487
1247189005135	ATP binding site [chemical binding]; other site
1247189005136	Mg++ binding site [ion binding]; other site
1247189005137	motif III; other site
1247189005138	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
1247189005139	nucleotide binding region [chemical binding]; other site
1247189005140	ATP-binding site [chemical binding]; other site
1247189005141	phospho-N-acetylmuramoyl-pentapeptide-transferase; Region: mraY; TIGR00445
1247189005142	Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852
1247189005143	Mg++ binding site [ion binding]; other site
1247189005144	putative catalytic motif [active]
1247189005145	putative substrate binding site [chemical binding]; other site
1247189005146	Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717
1247189005147	Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768
1247189005148	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905
1247189005149	PASTA domain of PBP2x-like proteins, first repeat. Penicillin-binding proteins (PBPs) are the major targets for beta-lactam antibiotics, like penicillins and cephalosporins. Beta-lactam antibiotics specifically inhibit transpeptidase activity by...; Region: PASTA_Pbp2x-like_1; cd06576
1247189005150	PASTA domain of PBP2x-like proteins, second repeat. Penicillin-binding proteins (PBPs) are the major targets for beta-lactam antibiotics, like penicillins and cephalosporins. Beta-lactam antibiotics specifically inhibit transpeptidase activity by...; Region: PASTA_Pbp2x-like_2; cd06575
1247189005151	Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717
1247189005152	Protein required for the initiation of cell division [Cell division and chromosome partitioning]; Region: FtsL; COG4839
1247189005153	Predicted S-adenosylmethionine-dependent methyltransferase involved in cell envelope biogenesis [Cell envelope biogenesis, outer membrane]; Region: COG0275
1247189005154	MraW methylase family; Region: Methyltransf_5; pfam01795
1247189005155	Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079
1247189005156	gamma-glutamyl phosphate reductase; Region: proA; TIGR00407
1247189005157	putative catalytic cysteine [active]
1247189005158	Glutamate 5-kinase [Amino acid transport and metabolism]; Region: ProB; COG0263
1247189005159	AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242
1247189005160	nucleotide binding site [chemical binding]; other site
1247189005161	homotetrameric interface [polypeptide binding]; other site
1247189005162	putative phosphate binding site [ion binding]; other site
1247189005163	putative allosteric binding site; other site
1247189005164	ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122
1247189005165	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
1247189005166	Walker A/P-loop; other site
1247189005167	ATP binding site [chemical binding]; other site
1247189005168	Q-loop/lid; other site
1247189005169	ABC transporter signature motif; other site
1247189005170	Walker B; other site
1247189005171	D-loop; other site
1247189005172	H-loop/switch region; other site
1247189005173	Transketolase [Carbohydrate transport and metabolism]; Region: TktA; COG0021
1247189005174	Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012
1247189005175	TPP-binding site [chemical binding]; other site
1247189005176	dimer interface [polypeptide binding]; other site
1247189005177	Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033
1247189005178	PYR/PP interface [polypeptide binding]; other site
1247189005179	dimer interface [polypeptide binding]; other site
1247189005180	TPP binding site [chemical binding]; other site
1247189005181	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
1247189005182	Transaldolase-like fructose-6-phosphate aldolases (FSA) found in bacteria and archaea; Region: Transaldolase_FSA; cd00956
1247189005183	active site
1247189005184	intersubunit interactions; other site
1247189005185	catalytic residue [active]
1247189005186	Mga helix-turn-helix domain; Region: Mga; pfam05043
1247189005187	Uncharacterized NAD(FAD)-dependent dehydrogenases [General function prediction only]; Region: HcaD; COG0446
1247189005188	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
1247189005189	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
1247189005190	Glycerol uptake facilitator and related permeases (Major Intrinsic Protein Family) [Carbohydrate transport and metabolism]; Region: GlpF; COG0580
1247189005191	amphipathic channel; other site
1247189005192	Asn-Pro-Ala signature motifs; other site
1247189005193	Glycerol-3-phosphate dehydrogenase [Energy production and conversion]; Region: GlpA; COG0578
1247189005194	Glycerol-3-phosphate dehydrogenase [Energy production and conversion]; Region: GlpA; COG0578
1247189005195	glycerol kinase; Provisional; Region: glpK; PRK00047
1247189005196	Escherichia coli glycerol kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_EcGK_like; cd07786
1247189005197	N- and C-terminal domain interface [polypeptide binding]; other site
1247189005198	active site
1247189005199	MgATP binding site [chemical binding]; other site
1247189005200	catalytic site [active]
1247189005201	metal binding site [ion binding]; metal-binding site
1247189005202	glycerol binding site [chemical binding]; other site
1247189005203	homotetramer interface [polypeptide binding]; other site
1247189005204	homodimer interface [polypeptide binding]; other site
1247189005205	FBP binding site [chemical binding]; other site
1247189005206	protein IIAGlc interface [polypeptide binding]; other site
1247189005207	Predicted membrane protein [Function unknown]; Region: COG3212
1247189005208	Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413
1247189005209	Bacterial protein of unknown function (DUF896); Region: DUF896; cl01722
1247189005210	glycyl-tRNA synthetase subunit beta; Validated; Region: glyS; PRK01233
1247189005211	Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020
1247189005212	Class II Glycyl-tRNA synthetase (GlyRS) alpha subunit core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes and in arabidopsis. It is responsible for the...; Region: GlyRS_alpha_core; cd00733
1247189005213	dimer interface [polypeptide binding]; other site
1247189005214	motif 1; other site
1247189005215	active site
1247189005216	motif 2; other site
1247189005217	motif 3; other site
1247189005218	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1755
1247189005219	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
1247189005220	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
1247189005221	active site
1247189005222	catalytic tetrad [active]
1247189005223	N-acetylglucosamine-6-phosphate deacetylase [Carbohydrate transport and metabolism]; Region: NagA; COG1820
1247189005224	N-acetylglucosamine-6-phosphate deacetylase, NagA, catalyzes the hydrolysis of the N-acetyl group of N-acetyl-glucosamine-6-phosphate (GlcNAc-6-P) to glucosamine 6-phosphate and acetate. This is the first committed step in the biosynthetic pathway to...; Region: NagA; cd00854
1247189005225	active site
1247189005226	dimer interface [polypeptide binding]; other site
1247189005227	Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690
1247189005228	phosphate transport system regulatory protein PhoU; Region: phoU_full; TIGR02135
1247189005229	PhoU domain; Region: PhoU; pfam01895
1247189005230	PhoU domain; Region: PhoU; pfam01895
1247189005231	Na+/phosphate symporter [Inorganic ion transport and metabolism]; Region: NptA; COG1283
1247189005232	Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690
1247189005233	valyl-tRNA synthetase; Provisional; Region: valS; PRK14900
1247189005234	Uncharacterized protein conserved in bacteria [Function unknown]; Region: DegV; COG1307
1247189005235	Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645
1247189005236	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
1247189005237	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
1247189005238	Predicted hydrolases of the HAD superfamily [General function prediction only]; Region: Cof; COG0561
1247189005239	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
1247189005240	active site
1247189005241	motif I; other site
1247189005242	motif II; other site
1247189005243	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
1247189005244	Predicted membrane protein [Function unknown]; Region: COG2860
1247189005245	UPF0126 domain; Region: UPF0126; pfam03458
1247189005246	UPF0126 domain; Region: UPF0126; pfam03458
1247189005247	tagatose 1,6-diphosphate aldolase; Reviewed; Region: PRK12399
1247189005248	1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164
1247189005249	tagatose-6-phosphate kinase; Region: lacC; TIGR01231
1247189005250	putative substrate binding site [chemical binding]; other site
1247189005251	putative ATP binding site [chemical binding]; other site
1247189005252	galactose-6-phosphate isomerase subunit LacB; Reviewed; Region: PRK08622
1247189005253	galactose-6-phosphate isomerase subunit LacA; Provisional; Region: PRK12613
1247189005254	Phosphotransferase system, galactitol-specific IIC component [Carbohydrate transport and metabolism]; Region: GatC; COG3775
1247189005255	PTS system sugar-specific permease component; Region: EIIC-GAT; pfam03611
1247189005256	Phosphotransferase system, galactitol-specific IIB component [Carbohydrate transport and metabolism]; Region: SgaB; COG3414
1247189005257	active site
1247189005258	P-loop; other site
1247189005259	phosphorylation site [posttranslational modification]
1247189005260	Phosphotransferase system mannitol/fructose-specific IIA domain (Ntr-type) [Carbohydrate transport and metabolism / Signal transduction mechanisms]; Region: PtsN; COG1762
1247189005261	active site
1247189005262	phosphorylation site [posttranslational modification]
1247189005263	Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349
1247189005264	helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420
1247189005265	DeoR C terminal sensor domain; Region: DeoRC; pfam00455
1247189005266	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371
1247189005267	metal-binding site [ion binding]
1247189005268	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217
1247189005269	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371
1247189005270	metal-binding site [ion binding]
1247189005271	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
1247189005272	Soluble P-type ATPase [General function prediction only]; Region: COG4087
1247189005273	Predicted transcriptional regulator [Transcription]; Region: COG3682
1247189005274	copper transport repressor, CopY/TcrY family; Region: CopY_TcrY; TIGR02698
1247189005275	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
1247189005276	Transposase DDE domain; Region: DDE_Tnp_1_3; pfam13612
1247189005277	Sortase B (SrtB) or subfamily-2 sortases are membrane cysteine transpeptidases found in gram-positive bacteria that anchor surface proteins to peptidoglycans of the bacterial cell wall envelope. This involves a transpeptidation reaction in which the...; Region: Sortase_B_2; cd05826
1247189005278	active site
1247189005279	catalytic site [active]
1247189005280	T surface-antigen of pili; Region: FctA; pfam12892
1247189005281	sortase B signal domain, QVPTGV class; Region: srtB_sig_QVPTGV; TIGR03065
1247189005282	signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227
1247189005283	The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530
1247189005284	Catalytic site [active]
1247189005285	Fibronectin-binding protein signal sequence; Region: Fb_signal; pfam08341
1247189005286	TQXA domain; Region: TQXA_dom; TIGR03934
1247189005287	T surface-antigen of pili; Region: FctA; cl16948
1247189005288	Cna protein B-type domain; Region: Cna_B; pfam05738
1247189005289	YSIRK-targeted surface antigen transcriptional regulator; Region: adjacent_YSIRK; TIGR04094
1247189005290	DeoR-like helix-turn-helix domain; Region: HTH_DeoR; cl17531
1247189005291	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1247189005292	Transposase DDE domain; Region: DDE_Tnp_1_3; pfam13612
1247189005293	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
1247189005294	Esterase/lipase [Lipid metabolism]; Region: Aes; COG0657
1247189005295	Protein of unknown function (DUF2424); Region: DUF2424; pfam10340
1247189005296	ribosome-binding factor A; Validated; Region: rbfA; PRK00521
1247189005297	Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760
1247189005298	translation initiation factor IF-2; Region: IF-2; TIGR00487
1247189005299	Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760
1247189005300	Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887
1247189005301	G1 box; other site
1247189005302	putative GEF interaction site [polypeptide binding]; other site
1247189005303	GTP/Mg2+ binding site [chemical binding]; other site
1247189005304	Switch I region; other site
1247189005305	G2 box; other site
1247189005306	G3 box; other site
1247189005307	Switch II region; other site
1247189005308	G4 box; other site
1247189005309	G5 box; other site
1247189005310	This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702
1247189005311	Translation-initiation factor 2; Region: IF-2; pfam11987
1247189005312	mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692
1247189005313	hypothetical protein; Provisional; Region: PRK07283
1247189005314	transcription elongation factor NusA; Provisional; Region: nusA; PRK12327
1247189005315	NusA N-terminal domain; Region: NusA_N; pfam08529
1247189005316	S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455
1247189005317	RNA binding site [nucleotide binding]; other site
1247189005318	homodimer interface [polypeptide binding]; other site
1247189005319	NusA-like KH domain; Region: KH_5; pfam13184
1247189005320	NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134
1247189005321	G-X-X-G motif; other site
1247189005322	ribosome maturation protein RimP; Reviewed; Region: PRK00092
1247189005323	Bacillus subtilis YxlS-like, C-terminal domain; Region: YlxS_C; cd01734
1247189005324	putative oligomer interface [polypeptide binding]; other site
1247189005325	putative RNA binding site [nucleotide binding]; other site
1247189005326	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1247189005327	S-adenosylmethionine binding site [chemical binding]; other site
1247189005328	Thiamine kinase and related kinases [Coenzyme transport and metabolism]; Region: ycfN; COG0510
1247189005329	Phosphotransferase enzyme family; Region: APH; pfam01636
1247189005330	substrate binding site [chemical binding]; other site
1247189005331	Bacterial ABC transporter protein EcsB; Region: EcsB; cl11542
1247189005332	Bacterial ABC transporter protein EcsB; Region: EcsB; pfam05975
1247189005333	ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555
1247189005334	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
1247189005335	Walker A/P-loop; other site
1247189005336	ATP binding site [chemical binding]; other site
1247189005337	Q-loop/lid; other site
1247189005338	ABC transporter signature motif; other site
1247189005339	Walker B; other site
1247189005340	D-loop; other site
1247189005341	H-loop/switch region; other site
1247189005342	HINT (histidine triad nucleotide-binding protein) subgroup: Members of this CD belong to the superfamily of histidine triad hydrolases that act on alpha-phosphate of ribonucleotides. This subgroup includes members from all three forms of cellular life; Region: HINT_subgroup; cd01277
1247189005343	HIT family signature motif; other site
1247189005344	catalytic residue [active]
1247189005345	Transcriptional regulator [Transcription]; Region: LytR; COG1316
1247189005346	Cell envelope-related transcriptional attenuator domain; Region: LytR_cpsA_psr; cl00581
1247189005347	Coenzyme A binding pocket [chemical binding]; other site
1247189005348	Acetyltransferases [General function prediction only]; Region: RimI; COG0456
1247189005349	Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583
1247189005350	Predicted ATPase or kinase [General function prediction only]; Region: COG0802
1247189005351	Sulfate transporter family; Region: Sulfate_transp; pfam00916
1247189005352	Xanthine/uracil/vitamin C permease [Nucleotide transport and    metabolism]; Region: COG2252
1247189005353	Xanthine/uracil/vitamin C permease [Nucleotide transport and    metabolism]; Region: COG2252
1247189005354	haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282
1247189005355	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
1247189005356	active site
1247189005357	motif I; other site
1247189005358	motif II; other site
1247189005359	PTS system mannose-specific transporter subunits IIAB; Provisional; Region: PRK15088
1247189005360	PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006
1247189005361	active pocket/dimerization site; other site
1247189005362	active site
1247189005363	phosphorylation site [posttranslational modification]
1247189005364	PTS_IIB, PTS system, Mannose/sorbose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_man; cd00001
1247189005365	active site
1247189005366	phosphorylation site [posttranslational modification]
1247189005367	PTS system mannose-specific transporter subunit IIC; Provisional; Region: PRK15065
1247189005368	Phosphotransferase system, mannose/fructose/N-acetylgalactosamine-specific component IID [Carbohydrate transport and metabolism]; Region: ManZ; COG3716
1247189005369	Domain of unknown function (DUF956); Region: DUF956; pfam06115
1247189005370	Predicted O-acyltransferase [General function prediction only]; Region: COG3274
1247189005371	seryl-tRNA synthetase; Provisional; Region: PRK05431
1247189005372	Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403
1247189005373	Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770
1247189005374	dimer interface [polypeptide binding]; other site
1247189005375	active site
1247189005376	motif 1; other site
1247189005377	motif 2; other site
1247189005378	motif 3; other site
1247189005379	acetyl-CoA carboxylase subunit alpha; Provisional; Region: PRK12319
1247189005380	acetyl-CoA carboxylase subunit beta; Validated; Region: PRK05654
1247189005381	malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682
1247189005382	acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591
1247189005383	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
1247189005384	Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786
1247189005385	Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878
1247189005386	FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288
1247189005387	The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850
1247189005388	carboxyltransferase (CT) interaction site; other site
1247189005389	biotinylation site [posttranslational modification]; other site
1247189005390	acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated; Region: PRK06302
1247189005391	Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404
1247189005392	3-oxoacyl-(acyl carrier protein) synthase II; Reviewed; Region: PRK07314
1247189005393	Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834
1247189005394	dimer interface [polypeptide binding]; other site
1247189005395	active site
1247189005396	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557
1247189005397	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
1247189005398	NAD(P) binding site [chemical binding]; other site
1247189005399	active site
1247189005400	(acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331
1247189005401	malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128
1247189005402	putative enoyl-[acyl-carrier-protein] reductase II; Region: enACPred_II; TIGR03151
1247189005403	2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730
1247189005404	FMN binding site [chemical binding]; other site
1247189005405	substrate binding site [chemical binding]; other site
1247189005406	putative catalytic residue [active]
1247189005407	acyl carrier protein; Provisional; Region: acpP; PRK00982
1247189005408	3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352
1247189005409	Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830
1247189005410	dimer interface [polypeptide binding]; other site
1247189005411	active site
1247189005412	CoA binding pocket [chemical binding]; other site
1247189005413	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
1247189005414	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
1247189005415	putative Zn2+ binding site [ion binding]; other site
1247189005416	putative DNA binding site [nucleotide binding]; other site
1247189005417	enoyl-CoA hydratase; Provisional; Region: PRK07260
1247189005418	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
1247189005419	substrate binding site [chemical binding]; other site
1247189005420	oxyanion hole (OAH) forming residues; other site
1247189005421	trimer interface [polypeptide binding]; other site
1247189005422	chaperone protein DnaJ; Provisional; Region: PRK14276
1247189005423	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257
1247189005424	HSP70 interaction site [polypeptide binding]; other site
1247189005425	C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cl03262
1247189005426	substrate binding site [polypeptide binding]; other site
1247189005427	Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719
1247189005428	Zn binding sites [ion binding]; other site
1247189005429	C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747
1247189005430	dimer interface [polypeptide binding]; other site
1247189005431	Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020
1247189005432	molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290
1247189005433	Nucleotide-binding domain of human HSPA9 and similar proteins; Region: HSPA9-Ssq1-like_NBD; cd10234
1247189005434	nucleotide binding site [chemical binding]; other site
1247189005435	NEF interaction site [polypeptide binding]; other site
1247189005436	SBD interface [polypeptide binding]; other site
1247189005437	GrpE; Region: GrpE; pfam01025
1247189005438	GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446
1247189005439	dimer interface [polypeptide binding]; other site
1247189005440	hsp70 (ATPase domain) interactions [polypeptide binding]; other site
1247189005441	heat-inducible transcription repressor; Provisional; Region: hrcA; PRK00082
1247189005442	Winged helix-turn-helix transcription repressor, HrcA DNA-binding; Region: HrcA_DNA-bdg; pfam03444
1247189005443	Mannosyl-glycoprotein endo-beta-N-acetylglucosaminidase; Region: Glucosaminidase; cl17361
1247189005444	D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: VanY; COG1876
1247189005445	D-alanyl-D-alanine carboxypeptidase; Region: VanY; pfam02557
1247189005446	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
1247189005447	catalytic core [active]
1247189005448	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
1247189005449	Predicted membrane protein [Function unknown]; Region: COG2261
1247189005450	Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950
1247189005451	aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477
1247189005452	GatB/GatE catalytic domain; Region: GatB_N; pfam02934
1247189005453	GatB domain; Region: GatB_Yqey; pfam02637
1247189005454	Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154
1247189005455	aspartyl/glutamyl-tRNA amidotransferase subunit A; Reviewed; Region: gatA; PRK00012
1247189005456	aspartyl/glutamyl-tRNA amidotransferase subunit C; Reviewed; Region: gatC; PRK00034
1247189005457	pyruvate phosphate dikinase; Provisional; Region: PRK09279
1247189005458	Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326
1247189005459	PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391
1247189005460	PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896
1247189005461	PEP synthetase regulatory protein; Provisional; Region: PRK05339
1247189005462	FOG: CBS domain [General function prediction only]; Region: COG0517
1247189005463	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_4; cd04617
1247189005464	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158
1247189005465	active site residue [active]
1247189005466	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
1247189005467	CoA-disulfide reductase; Region: CoA_CoA_reduc; TIGR03385
1247189005468	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
1247189005469	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
1247189005470	Member of the Rhodanese Homology Domain superfamily. Included in this CD are the Lactococcus lactis NADH oxidase, Bacillus cereus NADH dehydrogenase, and Bacteroides thetaiotaomicron pyridine nucleotide-disulphide oxidoreductase, and similar...; Region: RHOD_Pyr_redox; cd01524
1247189005471	active site residue [active]
1247189005472	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158
1247189005473	active site residue [active]
1247189005474	Uncharacterized protein YrkD from Bacillus subtilis and related domains; this domain superfamily was previously known as part of DUF156; Region: BsYrkD-like_DUF156; cd10155
1247189005475	putative homodimer interface [polypeptide binding]; other site
1247189005476	putative homotetramer interface [polypeptide binding]; other site
1247189005477	putative metal binding site [ion binding]; other site
1247189005478	putative homodimer-homodimer interface [polypeptide binding]; other site
1247189005479	putative allosteric switch controlling residues; other site
1247189005480	Isochorismatase family; Region: Isochorismatase; pfam00857
1247189005481	Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431
1247189005482	catalytic triad [active]
1247189005483	conserved cis-peptide bond; other site
1247189005484	Pleiotropic transcriptional repressor [Transcription]; Region: CodY; COG4465
1247189005485	CodY GAF-like domain; Region: CodY; pfam06018
1247189005486	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
1247189005487	dimerization interface [polypeptide binding]; other site
1247189005488	putative Zn2+ binding site [ion binding]; other site
1247189005489	putative DNA binding site [nucleotide binding]; other site
1247189005490	aminotransferase AlaT; Validated; Region: PRK09265
1247189005491	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
1247189005492	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1247189005493	homodimer interface [polypeptide binding]; other site
1247189005494	catalytic residue [active]
1247189005495	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
1247189005496	Ligand Binding Site [chemical binding]; other site
1247189005497	Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain superfamily; Region: NTP-PPase; cl16941
1247189005498	haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282
1247189005499	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cl17915
1247189005500	Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain superfamily; Region: NTP-PPase; cl16941
1247189005501	Predicted hydrolases of the HAD superfamily [General function prediction only]; Region: Cof; COG0561
1247189005502	Type II (periplasmic) bacterial L-asparaginase; Region: L-asparaginase_II; cd08964
1247189005503	active site
1247189005504	homotetramer interface [polypeptide binding]; other site
1247189005505	homodimer interface [polypeptide binding]; other site
1247189005506	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
1247189005507	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
1247189005508	active site
1247189005509	catalytic tetrad [active]
1247189005510	DEAD-like helicases superfamily; Region: DEXDc; smart00487
1247189005511	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
1247189005512	ATP binding site [chemical binding]; other site
1247189005513	putative Mg++ binding site [ion binding]; other site
1247189005514	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
1247189005515	nucleotide binding region [chemical binding]; other site
1247189005516	ATP-binding site [chemical binding]; other site
1247189005517	RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488
1247189005518	generic binding surface II; other site
1247189005519	ssDNA binding site; other site
1247189005520	ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488
1247189005521	First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225
1247189005522	Walker A/P-loop; other site
1247189005523	ATP binding site [chemical binding]; other site
1247189005524	Q-loop/lid; other site
1247189005525	ABC transporter signature motif; other site
1247189005526	Walker B; other site
1247189005527	D-loop; other site
1247189005528	H-loop/switch region; other site
1247189005529	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1247189005530	Walker A/P-loop; other site
1247189005531	ATP binding site [chemical binding]; other site
1247189005532	Q-loop/lid; other site
1247189005533	ABC transporter signature motif; other site
1247189005534	Walker B; other site
1247189005535	D-loop; other site
1247189005536	H-loop/switch region; other site
1247189005537	Cobalt transport protein; Region: CbiQ; cl00463
1247189005538	Hypothetical bacterial integral membrane protein (Trep_Strep); Region: Trep_Strep; pfam09605
1247189005539	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
1247189005540	ATP-binding cassette domain of multidrug resistance protein-like transporters; Region: ABCC_MRP_Like; cd03228
1247189005541	Q-loop/lid; other site
1247189005542	ABC transporter signature motif; other site
1247189005543	Walker B; other site
1247189005544	D-loop; other site
1247189005545	H-loop/switch region; other site
1247189005546	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
1247189005547	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
1247189005548	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1247189005549	Walker A/P-loop; other site
1247189005550	ATP binding site [chemical binding]; other site
1247189005551	ABC-type transport system involved in cytochrome bd biosynthesis, ATPase and permease components [Energy production and conversion / Posttranslational modification, protein turnover, chaperones]; Region: CydD; COG4988
1247189005552	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
1247189005553	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1247189005554	Walker A/P-loop; other site
1247189005555	ATP binding site [chemical binding]; other site
1247189005556	Q-loop/lid; other site
1247189005557	ABC transporter signature motif; other site
1247189005558	Walker B; other site
1247189005559	D-loop; other site
1247189005560	H-loop/switch region; other site
1247189005561	ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120
1247189005562	ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214
1247189005563	Walker A/P-loop; other site
1247189005564	ATP binding site [chemical binding]; other site
1247189005565	Q-loop/lid; other site
1247189005566	ABC transporter signature motif; other site
1247189005567	Walker B; other site
1247189005568	D-loop; other site
1247189005569	H-loop/switch region; other site
1247189005570	iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577
1247189005571	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
1247189005572	ABC-ATPase subunit  interface; other site
1247189005573	dimer interface [polypeptide binding]; other site
1247189005574	putative PBP binding regions; other site
1247189005575	Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+.  Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262
1247189005576	Periplasmic binding protein; Region: Peripla_BP_2; pfam01497
1247189005577	intersubunit interface [polypeptide binding]; other site
1247189005578	Cell surface heme-binding protein Shp; Region: HemeBinding_Shp; pfam11545
1247189005579	Protein of unknown function (DUF1533); Region: DUF1533; pfam07550
1247189005580	Protein of unknown function (DUF1533); Region: DUF1533; pfam07550
1247189005581	NEAr Transport domain, a component of cell surface proteins; Region: NEAT; cd06920
1247189005582	heme-binding site [chemical binding]; other site
1247189005583	Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond...; Region: LRR_RI; cl15309
1247189005584	Leucine-rich repeats; other site
1247189005585	Leucine rich repeat; Region: LRR_8; pfam13855
1247189005586	Substrate binding site [chemical binding]; other site
1247189005587	Leucine-rich repeat (LRR) protein [Function unknown]; Region: COG4886
1247189005588	NEAr Transport domain, a component of cell surface proteins; Region: NEAT; cd06920
1247189005589	heme-binding site [chemical binding]; other site
1247189005590	Surface antigen [General function prediction only]; Region: COG3942
1247189005591	CHAP domain; Region: CHAP; pfam05257
1247189005592	alanine racemase; Reviewed; Region: alr; PRK00053
1247189005593	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430
1247189005594	active site
1247189005595	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
1247189005596	dimer interface [polypeptide binding]; other site
1247189005597	substrate binding site [chemical binding]; other site
1247189005598	catalytic residues [active]
1247189005599	4'-phosphopantetheinyl transferase; Provisional; Region: acpS; PRK00070
1247189005600	preprotein translocase subunit SecA; Reviewed; Region: PRK12904
1247189005601	SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958
1247189005602	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
1247189005603	nucleotide binding region [chemical binding]; other site
1247189005604	ATP-binding site [chemical binding]; other site
1247189005605	SEC-C motif; Region: SEC-C; pfam02810
1247189005606	Phosphomannose isomerase [Carbohydrate transport and metabolism]; Region: ManA; COG1482
1247189005607	mannose-6-phosphate isomerase, class I; Region: manA; TIGR00218
1247189005608	Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940
1247189005609	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012
1247189005610	nucleotide binding site [chemical binding]; other site
1247189005611	PTS system, sucrose-specific IIBC component; Region: PTS-II-BC-sucr; TIGR01996
1247189005612	PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212
1247189005613	active site turn [active]
1247189005614	phosphorylation site [posttranslational modification]
1247189005615	Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263
1247189005616	Phosphotransferase system IIA components [Carbohydrate transport and metabolism]; Region: NagE; COG2190
1247189005617	HPr interaction site; other site
1247189005618	glycerol kinase (GK) interaction site [polypeptide binding]; other site
1247189005619	active site
1247189005620	phosphorylation site [posttranslational modification]
1247189005621	sucrose-6-phosphate hydrolase; Region: scrB_fam; TIGR01322
1247189005622	Glycosyl hydrolase family 32, beta-fructosidases; Region: GH32_B_Fructosidase; cd08996
1247189005623	substrate binding [chemical binding]; other site
1247189005624	active site
1247189005625	Glycosyl hydrolases family 32 C terminal; Region: Glyco_hydro_32C; pfam08244
1247189005626	Transcriptional regulators [Transcription]; Region: PurR; COG1609
1247189005627	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
1247189005628	DNA binding site [nucleotide binding]
1247189005629	domain linker motif; other site
1247189005630	Ligand binding domain of the lacI-like transcription regulator from a novel metal-reducing bacterium Alkaliphilus Metalliredigens (strain Qymf) and its close homologs; Region: PBP1_Qymf_like; cd06291
1247189005631	dimerization interface [polypeptide binding]; other site
1247189005632	ligand binding site [chemical binding]; other site
1247189005633	sodium binding site [ion binding]; other site
1247189005634	transcription antitermination protein NusB; Reviewed; Region: nusB; PRK00202
1247189005635	putative RNA binding site [nucleotide binding]; other site
1247189005636	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1302
1247189005637	elongation factor P; Validated; Region: PRK00529
1247189005638	Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207
1247189005639	S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470
1247189005640	RNA binding site [nucleotide binding]; other site
1247189005641	S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794
1247189005642	RNA binding site [nucleotide binding]; other site
1247189005643	Deoxycytidylate deaminase domain. Deoxycytidylate deaminase catalyzes the deamination of dCMP to dUMP, providing the nucleotide substrate for thymidylate synthase. The enzyme binds Zn++, which is required for catalytic activity. The activity of the...; Region: deoxycytidylate_deaminase; cd01286
1247189005644	catalytic motif [active]
1247189005645	Zn binding site [ion binding]; other site
1247189005646	Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006
1247189005647	Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321
1247189005648	Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092
1247189005649	active site
1247189005650	excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349
1247189005651	ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270
1247189005652	ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270
1247189005653	ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271
1247189005654	Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598
1247189005655	uncharacterized bacterial subfamily of the Escherichia coli CorA-Salmonella typhimurium ZntB family; Region: EcCorA_ZntB-like_u2; cd12827
1247189005656	Cl binding site [ion binding]; other site
1247189005657	oligomer interface [polypeptide binding]; other site
1247189005658	Uncharacterized membrane-bound protein conserved in bacteria [Function unknown]; Region: COG4858
1247189005659	30S ribosomal protein S18; Reviewed; Region: rpsR; PRK00391
1247189005660	Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629
1247189005661	SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496
1247189005662	dimer interface [polypeptide binding]; other site
1247189005663	ssDNA binding site [nucleotide binding]; other site
1247189005664	tetramer (dimer of dimers) interface [polypeptide binding]; other site
1247189005665	30S ribosomal protein S6; Reviewed; Region: rpsF; PRK00453
1247189005666	A/G-specific DNA glycosylase [DNA replication, recombination, and repair]; Region: MutY; COG1194
1247189005667	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056
1247189005668	minor groove reading motif; other site
1247189005669	helix-hairpin-helix signature motif; other site
1247189005670	substrate binding pocket [chemical binding]; other site
1247189005671	active site
1247189005672	DNA glycosylase (MutY in bacteria and hMYH in humans) is responsible for repairing misread  A*oxoG residues to C*G by removing the inappropriately paired adenine base from the DNA backbone. It belongs to the Nudix hydrolase superfamily and is important...; Region: DNA_Glycosylase_C; cd03431
1247189005673	DNA binding and oxoG recognition site [nucleotide binding]
1247189005674	TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947
1247189005675	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
1247189005676	catalytic residues [active]
1247189005677	pyridine nucleotide-disulfide oxidoreductase; Provisional; Region: PRK07251
1247189005678	ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314
1247189005679	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
1247189005680	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
1247189005681	Mismatch repair ATPase (MutS family) [DNA replication, recombination, and repair]; Region: COG1193
1247189005682	MutS domain III; Region: MutS_III; pfam05192
1247189005683	ATP-binding cassette domain of MutS2; Region: ABC_MutS2; cd03280
1247189005684	Walker A/P-loop; other site
1247189005685	ATP binding site [chemical binding]; other site
1247189005686	Q-loop/lid; other site
1247189005687	ABC transporter signature motif; other site
1247189005688	Walker B; other site
1247189005689	D-loop; other site
1247189005690	H-loop/switch region; other site
1247189005691	Smr domain; Region: Smr; pfam01713
1247189005692	Uncharacterized membrane protein, required for colicin V production [General function prediction only]; Region: CvpA; COG1286
1247189005693	Colicin V production protein; Region: Colicin_V; pfam02674
1247189005694	RNase H is an endonuclease that cleaves the RNA strand of an RNA/DNA hybrid in a sequence non-specific manner; Region: RNase_H; cl14782
1247189005695	active site
1247189005696	RNA/DNA hybrid binding site [nucleotide binding]; other site
1247189005697	RNase H is an endonuclease that cleaves the RNA strand of an RNA/DNA hybrid in a sequence non-specific manner; Region: RNase_H; cl14782
1247189005698	signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227
1247189005699	The S24, S26 LexA/signal peptidase superfamily contains LexA-related and type I signal peptidase families. The S24 LexA protein domains include: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC 3.4.21.88), the...; Region: Peptidase_S24_S26; cd06462
1247189005700	Catalytic site [active]
1247189005701	The S24, S26 LexA/signal peptidase superfamily contains LexA-related and type I signal peptidase families. The S24 LexA protein domains include: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC 3.4.21.88), the...; Region: Peptidase_S24_S26; cl10465
1247189005702	helicase, putative, RecD/TraA family; Region: recD_rel; TIGR01448
1247189005703	H3TH domains of structure-specific 5' nucleases (or flap endonuclease-1-like) involved in DNA replication, repair, and recombination; Region: H3TH_StructSpec-5'-nucleases; cl14815
1247189005704	DNA binding site [nucleotide binding]
1247189005705	AAA domain; Region: AAA_30; pfam13604
1247189005706	Family description; Region: UvrD_C_2; pfam13538
1247189005707	DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586
1247189005708	active site
1247189005709	DNA polymerase IV; Validated; Region: PRK02406
1247189005710	DNA binding site [nucleotide binding]
1247189005711	formate acetyltransferase 1; Region: pyr_form_ly_1; TIGR01255
1247189005712	Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939
1247189005713	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
1247189005714	Coenzyme A binding pocket [chemical binding]; other site
1247189005715	N-terminal Early set domain associated with the catalytic domain of cyclomaltodextrinase and pullulan-degrading enzymes; Region: E_set_CDase_PDE_N; cd02857
1247189005716	homodimer interface [polypeptide binding]; other site
1247189005717	maltodextrin glucosidase; Provisional; Region: PRK10785
1247189005718	Alpha amylase catalytic domain found in cyclomaltodextrinases and related proteins; Region: AmyAc_CMD; cd11338
1247189005719	active site
1247189005720	homodimer interface [polypeptide binding]; other site
1247189005721	catalytic site [active]
1247189005722	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
1247189005723	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
1247189005724	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1247189005725	dimer interface [polypeptide binding]; other site
1247189005726	ABC-ATPase subunit interface; other site
1247189005727	ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209
1247189005728	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1247189005729	dimer interface [polypeptide binding]; other site
1247189005730	conserved gate region; other site
1247189005731	ABC-ATPase subunit interface; other site
1247189005732	Transcriptional regulators [Transcription]; Region: PurR; COG1609
1247189005733	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
1247189005734	DNA binding site [nucleotide binding]
1247189005735	domain linker motif; other site
1247189005736	Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267
1247189005737	dimerization interface [polypeptide binding]; other site
1247189005738	ligand binding site [chemical binding]; other site
1247189005739	Beta-lactamase; Region: Beta-lactamase; pfam00144
1247189005740	Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680
1247189005741	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632
1247189005742	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632
1247189005743	active site
1247189005744	Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cd00333
1247189005745	amphipathic channel; other site
1247189005746	Asn-Pro-Ala signature motifs; other site
1247189005747	x-prolyl-dipeptidyl aminopeptidase; Provisional; Region: PRK05371
1247189005748	X-Prolyl dipeptidyl aminopeptidase PepX, N-terminal; Region: PepX_N; pfam09168
1247189005749	X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain; Region: PepX_C; pfam08530
1247189005750	Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381
1247189005751	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
1247189005752	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
1247189005753	non-specific DNA binding site [nucleotide binding]; other site
1247189005754	salt bridge; other site
1247189005755	sequence-specific DNA binding site [nucleotide binding]; other site
1247189005756	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
1247189005757	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
1247189005758	non-specific DNA binding site [nucleotide binding]; other site
1247189005759	salt bridge; other site
1247189005760	sequence-specific DNA binding site [nucleotide binding]; other site
1247189005761	hypothetical protein; Validated; Region: PRK00153
1247189005762	Helix-Turn-Helix DNA binding domain of the transcription regulators TipAL, Mta, and SkgA; Region: HTH_TipAL-Mta; cd01106
1247189005763	MerR HTH family regulatory protein; Region: MerR_1; pfam13411
1247189005764	DNA binding residues [nucleotide binding]
1247189005765	dimer interface [polypeptide binding]; other site
1247189005766	DNA polymerase III, epsilon subunit and related 3'-5' exonucleases [DNA replication, recombination, and repair]; Region: DnaQ; COG0847
1247189005767	DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127
1247189005768	active site
1247189005769	catalytic site [active]
1247189005770	substrate binding site [chemical binding]; other site
1247189005771	HTH domain; Region: HTH_11; cl17392
1247189005772	HI0933-like protein; Region: HI0933_like; pfam03486
1247189005773	Chromate resistance exported protein; Region: Chrome_Resist; cl01744
1247189005774	DNA-directed RNA polymerase, subunit A'' Region: RNA_pol_rpoA2; TIGR02389
1247189005775	30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08881
1247189005776	UGMP family protein; Validated; Region: PRK09604
1247189005777	Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214; cl17884
1247189005778	Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673
1247189005779	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
1247189005780	Coenzyme A binding pocket [chemical binding]; other site
1247189005781	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
1247189005782	tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725
1247189005783	Glycoprotease family; Region: Peptidase_M22; pfam00814
1247189005784	hypothetical protein; Provisional; Region: PRK13667
1247189005785	mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595
1247189005786	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
1247189005787	mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595
1247189005788	RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521
1247189005789	ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124
1247189005790	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
1247189005791	Walker A/P-loop; other site
1247189005792	ATP binding site [chemical binding]; other site
1247189005793	Q-loop/lid; other site
1247189005794	ABC transporter signature motif; other site
1247189005795	Walker B; other site
1247189005796	D-loop; other site
1247189005797	H-loop/switch region; other site
1247189005798	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352
1247189005799	ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444
1247189005800	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
1247189005801	Q-loop/lid; other site
1247189005802	ABC transporter signature motif; other site
1247189005803	Walker B; other site
1247189005804	D-loop; other site
1247189005805	H-loop/switch region; other site
1247189005806	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
1247189005807	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1247189005808	Walker A/P-loop; other site
1247189005809	ATP binding site [chemical binding]; other site
1247189005810	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173
1247189005811	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1247189005812	dimer interface [polypeptide binding]; other site
1247189005813	conserved gate region; other site
1247189005814	putative PBP binding loops; other site
1247189005815	ABC-ATPase subunit interface; other site
1247189005816	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601
1247189005817	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1247189005818	dimer interface [polypeptide binding]; other site
1247189005819	conserved gate region; other site
1247189005820	putative PBP binding loops; other site
1247189005821	ABC-ATPase subunit interface; other site
1247189005822	ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166
1247189005823	The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504
1247189005824	peptide binding site [polypeptide binding]; other site
1247189005825	Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174
1247189005826	Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951
1247189005827	Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120
1247189005828	Helix-Turn-Helix DNA binding domain of GlnR-like transcription regulators; Region: HTH_GlnR-like; cd01105
1247189005829	MerR HTH family regulatory protein; Region: MerR_1; pfam13411
1247189005830	DNA binding residues [nucleotide binding]
1247189005831	putative dimer interface [polypeptide binding]; other site
1247189005832	Bacterial protein of unknown function (DUF939); Region: DUF939; pfam06081
1247189005833	Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515
1247189005834	phosphoglycerate kinase; Provisional; Region: pgk; PRK00073
1247189005835	Phosphoglycerate kinase; Region: PGK; pfam00162
1247189005836	substrate binding site [chemical binding]; other site
1247189005837	hinge regions; other site
1247189005838	ADP binding site [chemical binding]; other site
1247189005839	catalytic site [active]
1247189005840	5'-nucleotidase, lipoprotein e(P4) family; Region: lipo_e_P4; TIGR01533
1247189005841	Glyceraldehyde-3-phosphate dehydrogenase/erythrose-4-phosphate dehydrogenase [Carbohydrate transport and metabolism]; Region: GapA; COG0057
1247189005842	Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846
1247189005843	Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800
1247189005844	elongation factor G; Reviewed; Region: PRK00007
1247189005845	Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886
1247189005846	G1 box; other site
1247189005847	putative GEF interaction site [polypeptide binding]; other site
1247189005848	GTP/Mg2+ binding site [chemical binding]; other site
1247189005849	Switch I region; other site
1247189005850	G2 box; other site
1247189005851	G3 box; other site
1247189005852	Switch II region; other site
1247189005853	G4 box; other site
1247189005854	G5 box; other site
1247189005855	EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088
1247189005856	EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434
1247189005857	EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G.  Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713
1247189005858	30S ribosomal protein S7; Validated; Region: PRK05302
1247189005859	S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368
1247189005860	S17 interaction site [polypeptide binding]; other site
1247189005861	S8 interaction site; other site
1247189005862	16S rRNA interaction site [nucleotide binding]; other site
1247189005863	streptomycin interaction site [chemical binding]; other site
1247189005864	23S rRNA interaction site [nucleotide binding]; other site
1247189005865	aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site
1247189005866	SEC10/PgrA surface exclusion domain; Region: Surf_Exclu_PgrA; TIGR04320
1247189005867	pur operon repressor; Provisional; Region: PRK09213
1247189005868	Bacterial purine repressor, N-terminal; Region: PuR_N; pfam09182
1247189005869	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
1247189005870	active site
1247189005871	Predicted HD-superfamily hydrolase [General function prediction only]; Region: COG3481
1247189005872	YhaM_OBF_like: A subfamily of OB folds similar to that found in Bacillus subtilis YhaM and Staphylococcus aureus cmp-binding factor-1 (SaCBF1). Both these proteins are 3'-to-5'exoribonucleases. YhaM requires Mn2+ or Co2+ for activity and is...; Region: YhaM_OBF_like; cd04492
1247189005873	generic binding surface II; other site
1247189005874	generic binding surface I; other site
1247189005875	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
1247189005876	Zn2+ binding site [ion binding]; other site
1247189005877	Mg2+ binding site [ion binding]; other site
1247189005878	Predicted nuclease of restriction endonuclease-like fold, RmuC family [General function prediction only]; Region: COG1322
1247189005879	RmuC family; Region: RmuC; pfam02646
1247189005880	Thiamin pyrophosphokinase, vitamin B1 binding domain; Region: TPK_B1_binding; pfam04265
1247189005881	thiamine binding site [chemical binding]; other site
1247189005882	Thiamine pyrophosphokinase; Region: TPK; cl08415
1247189005883	Pentose-5-phosphate-3-epimerase [Carbohydrate transport and metabolism]; Region: Rpe; COG0036
1247189005884	Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429
1247189005885	substrate binding site [chemical binding]; other site
1247189005886	hexamer interface [polypeptide binding]; other site
1247189005887	metal binding site [ion binding]; metal-binding site
1247189005888	GTPase RsgA; Reviewed; Region: PRK00098
1247189005889	S1_YloQ_GTPase: YloQ GTase family (also known as YjeQ and CpgA), S1-like RNA-binding domain. Proteins in the YloQ GTase family bind the ribosome and have GTPase activity. The precise role of this family is unknown. The protein structure is composed of...; Region: S1_YloQ_GTPase; cd04466
1247189005890	RNA binding site [nucleotide binding]; other site
1247189005891	homodimer interface [polypeptide binding]; other site
1247189005892	Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854
1247189005893	GTPase/Zn-binding domain interface [polypeptide binding]; other site
1247189005894	GTP/Mg2+ binding site [chemical binding]; other site
1247189005895	G4 box; other site
1247189005896	G1 box; other site
1247189005897	Switch I region; other site
1247189005898	G2 box; other site
1247189005899	G3 box; other site
1247189005900	Switch II region; other site
1247189005901	16S ribosomal RNA methyltransferase KsgA/Dim1 family protein; Reviewed; Region: ksgA; PRK00274
1247189005902	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1247189005903	S-adenosylmethionine binding site [chemical binding]; other site
1247189005904	ribonuclease M5; Region: 5S_RNA_mat_M5; TIGR00334
1247189005905	TOPRIM_ RNase M5_like: The topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain found in Ribonuclease M5: (RNase M5) and other small primase-like proteins from bacteria and archaea.  RNase M5 catalyzes the maturation of 5S rRNA in low...; Region: TOPRIM_RNase_M5_like; cd01027
1247189005906	putative active site [active]
1247189005907	putative metal binding site [ion binding]; other site
1247189005908	Domain of unknown function (DUF4093); Region: DUF4093; pfam13331
1247189005909	TatD like proteins;  E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310
1247189005910	active site
1247189005911	Isochorismatase family; Region: Isochorismatase; pfam00857
1247189005912	Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431
1247189005913	catalytic triad [active]
1247189005914	conserved cis-peptide bond; other site
1247189005915	Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418
1247189005916	Transcriptional regulators [Transcription]; Region: RpiR; COG1737
1247189005917	RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013
1247189005918	putative active site [active]
1247189005919	Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940
1247189005920	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037
1247189005921	Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940
1247189005922	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012
1247189005923	nucleotide binding site [chemical binding]; other site
1247189005924	Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329
1247189005925	Class I aldolases; Region: Aldolase_Class_I; cl17187
1247189005926	catalytic residue [active]
1247189005927	Protein of unknown function, DUF624; Region: DUF624; pfam04854
1247189005928	Domain of unknown function (DUF386); Region: DUF386; cl01047
1247189005929	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
1247189005930	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1247189005931	dimer interface [polypeptide binding]; other site
1247189005932	conserved gate region; other site
1247189005933	putative PBP binding loops; other site
1247189005934	ABC-ATPase subunit interface; other site
1247189005935	ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209
1247189005936	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1247189005937	dimer interface [polypeptide binding]; other site
1247189005938	ABC-ATPase subunit interface; other site
1247189005939	putative PBP binding loops; other site
1247189005940	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
1247189005941	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
1247189005942	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
1247189005943	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
1247189005944	N-acetylmannosamine-6-phosphate epimerase (NanE) converts N-acetylmannosamine-6-phosphate to N-acetylglucosamine-6-phosphate. This reaction is part of the pathway that allows the usage of sialic acid as a carbohydrate source. Sialic acids are a family of...; Region: NanE; cd04729
1247189005945	N-acetylmannosamine-6-phosphate 2-epimerase; Provisional; Region: PRK01130
1247189005946	putative active site cavity [active]
1247189005947	Ribosomal protein L34; Region: Ribosomal_L34; cl00370
1247189005948	Predicted RNA-binding protein [General function prediction only]; Region: Jag; COG1847
1247189005949	jag_K homology RNA-binding domain. The KH domain is found in proteins homologous to the Bacillus subtilis protein Jag, which is associated with SpoIIIJ and is necessary for the third stage of sporulation.  The KH motif is a beta-alpha-alpha-beta-beta...; Region: jag_KH; cd02414
1247189005950	G-X-X-G motif; other site
1247189005951	R3H domain found in proteins homologous to Bacillus subtilus Jag, which is associated with SpoIIIJ. SpoIIIJ is necessary for the third stage of sporulation. The name of the R3H domain comes from the characteristic spacing of the most conserved arginine...; Region: R3H_jag; cd02644
1247189005952	RxxxH motif; other site
1247189005953	60Kd inner membrane protein; Region: 60KD_IMP; cl00489
1247189005954	membrane protein insertase, YidC/Oxa1 family, C-terminal domain; Region: yidC_oxa1_cterm; TIGR03592
1247189005955	ribonuclease P; Reviewed; Region: rnpA; PRK00499
1247189005956	Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279
1247189005957	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1247189005958	active site
1247189005959	phosphorylation site [posttranslational modification]
1247189005960	intermolecular recognition site; other site
1247189005961	dimerization interface [polypeptide binding]; other site
1247189005962	LytTr DNA-binding domain; Region: LytTR; pfam04397
1247189005963	Predicted signal transduction protein with a C-terminal ATPase domain [Signal transduction mechanisms]; Region: COG2972
1247189005964	Predicted signal transduction protein with a C-terminal ATPase domain [Signal transduction mechanisms]; Region: COG2972
1247189005965	Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518
1247189005966	glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406
1247189005967	catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808
1247189005968	active site
1247189005969	HIGH motif; other site
1247189005970	catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808
1247189005971	active site
1247189005972	KMSKS motif; other site
1247189005973	PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cl00025
1247189005974	H+ Antiporter protein; Region: 2A0121; TIGR00900
1247189005975	LytTr DNA-binding domain; Region: LytTR; smart00850
1247189005976	Uncharacterized conserved protein [Function unknown]; Region: COG2013
1247189005977	Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeD; cd03379
1247189005978	active site clefts [active]
1247189005979	zinc binding site [ion binding]; other site
1247189005980	dimer interface [polypeptide binding]; other site
1247189005981	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
1247189005982	Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541
1247189005983	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
1247189005984	AAA domain; Region: AAA_25; pfam13481
1247189005985	Walker A motif; other site
1247189005986	ATP binding site [chemical binding]; other site
1247189005987	Walker B motif; other site
1247189005988	Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557
1247189005989	trimer interface [polypeptide binding]; other site
1247189005990	active site
1247189005991	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1636
1247189005992	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
1247189005993	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
1247189005994	ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254
1247189005995	Walker A/P-loop; other site
1247189005996	ATP binding site [chemical binding]; other site
1247189005997	Q-loop/lid; other site
1247189005998	ABC transporter signature motif; other site
1247189005999	Walker B; other site
1247189006000	D-loop; other site
1247189006001	H-loop/switch region; other site
1247189006002	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
1247189006003	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
1247189006004	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1247189006005	Walker A/P-loop; other site
1247189006006	ATP binding site [chemical binding]; other site
1247189006007	Q-loop/lid; other site
1247189006008	ABC transporter signature motif; other site
1247189006009	Walker B; other site
1247189006010	D-loop; other site
1247189006011	H-loop/switch region; other site
1247189006012	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
1247189006013	MarR family; Region: MarR_2; pfam12802
1247189006014	NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094
1247189006015	NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210
1247189006016	NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479
1247189006017	Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541
1247189006018	dTDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: RfbA; COG1209
1247189006019	active site
1247189006020	tetramer interface; other site
1247189006021	Predicted membrane protein [Function unknown]; Region: COG2364
1247189006022	Membrane associated serine protease [Amino acid transport and metabolism]; Region: COG0705
1247189006023	5-formyltetrahydrofolate cyclo-ligase family; Region: 5-FTHF_cyc-lig; pfam01812
1247189006024	5,10-methenyltetrahydrofolate synthetase; Region: MTHFS_bact; TIGR02727
1247189006025	Fibronectin-binding protein signal sequence; Region: Fb_signal; pfam08341
1247189006026	TQXA domain; Region: TQXA_dom; TIGR03934
1247189006027	Fibronectin binding repeat; Region: Fn_bind; pfam02986
1247189006028	Fibronectin binding repeat; Region: Fn_bind; pfam02986
1247189006029	Gram positive anchor; Region: Gram_pos_anchor; pfam00746
1247189006030	Helix-turn-helix domain; Region: HTH_38; pfam13936
1247189006031	Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826
1247189006032	Integrase core domain; Region: rve; pfam00665
1247189006033	M protein trans-acting positive regulator (MGA) HTH domain; Region: HTH_Mga; pfam08280
1247189006034	Mga helix-turn-helix domain; Region: Mga; pfam05043
1247189006035	M protein trans-acting positive regulator (MGA) PRD domain; Region: PRD_Mga; pfam08270
1247189006036	Helix-turn-helix domain; Region: HTH_38; pfam13936
1247189006037	Winged helix-turn helix; Region: HTH_29; pfam13551
1247189006038	glucose-6-phosphate isomerase; Provisional; Region: pgi; PRK14097
1247189006039	Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015
1247189006040	active site
1247189006041	dimer interface [polypeptide binding]; other site
1247189006042	Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016
1247189006043	dimer interface [polypeptide binding]; other site
1247189006044	active site
1247189006045	TlpA-like family; composed of  TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966
1247189006046	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
1247189006047	catalytic residues [active]
1247189006048	Staphylococcal/Streptococcal toxin, OB-fold domain; Region: Stap_Strp_toxin; pfam01123
1247189006049	Staphylococcal/Streptococcal toxin, beta-grasp domain; Region: Stap_Strp_tox_C; pfam02876
1247189006050	pyruvate:ferredoxin (flavodoxin) oxidoreductase, homodimeric; Region: pyruv_ox_red; TIGR02176
1247189006051	Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034
1247189006052	dimer interface [polypeptide binding]; other site
1247189006053	PYR/PP interface [polypeptide binding]; other site
1247189006054	TPP binding site [chemical binding]; other site
1247189006055	substrate binding site [chemical binding]; other site
1247189006056	Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, gamma subunit [Energy production and conversion]; Region: PorG; COG1014
1247189006057	Domain of unknown function; Region: EKR; cl11037
1247189006058	4Fe-4S binding domain; Region: Fer4; pfam00037
1247189006059	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655
1247189006060	Thiamine pyrophosphate (TPP family), PFOR_PNO subfamily, TPP-binding module; composed of proteins similar to the single subunit pyruvate ferredoxin oxidoreductase (PFOR) of Desulfovibrio Africanus, present in bacteria and amitochondriate eukaryotes. This...; Region: TPP_PFOR_PNO; cd03377
1247189006061	TPP-binding site [chemical binding]; other site
1247189006062	dimer interface [polypeptide binding]; other site
1247189006063	Carbon dioxide concentrating mechanism/carboxysome shell protein [Secondary metabolites biosynthesis, transport, and catabolism / Energy production and conversion]; Region: CcmK; COG4577
1247189006064	1,2-propanediol utilization protein A (PduA), Bacterial Micro-Compartment (BMC) domain; Region: BMC_PduA; cd07059
1247189006065	Hexamer interface [polypeptide binding]; other site
1247189006066	Putative hexagonal pore residue; other site
1247189006067	Carbon dioxide concentrating mechanism/carboxysome shell protein [Secondary metabolites biosynthesis, transport, and catabolism / Energy production and conversion]; Region: CcmK; COG4577
1247189006068	1,2-propanediol utilization protein A (PduA), Bacterial Micro-Compartment (BMC) domain; Region: BMC_PduA; cd07059
1247189006069	Hexamer interface [polypeptide binding]; other site
1247189006070	Putative hexagonal pore residue; other site
1247189006071	Carbon dioxide concentrating mechanism/carboxysome shell protein [Secondary metabolites biosynthesis, transport, and catabolism / Energy production and conversion]; Region: CcmK; COG4577
1247189006072	1,2-propanediol utilization protein A (PduA), Bacterial Micro-Compartment (BMC) domain; Region: BMC_PduA; cd07059
1247189006073	Hexamer interface [polypeptide binding]; other site
1247189006074	Putative hexagonal pore residue; other site
1247189006075	propanediol utilization phosphotransacylase; Provisional; Region: PRK15070
1247189006076	Propanediol utilisation protein PduL; Region: PduL; pfam06130
1247189006077	Propanediol utilisation protein PduL; Region: PduL; pfam06130
1247189006078	NAD-dependent aldehyde dehydrogenases [Energy production and conversion]; Region: PutA; COG1012
1247189006079	Coenzyme A acylating aldehyde dehydrogenase (ACDH), ALDH family 20-like; Region: ALDH_F20_ACDH; cd07122
1247189006080	putative catalytic cysteine [active]
1247189006081	Carbon dioxide concentrating mechanism/carboxysome shell protein [Secondary metabolites biosynthesis, transport, and catabolism / Energy production and conversion]; Region: CcmK; COG4577
1247189006082	Carbon dioxide concentrating mechanism K (CcmK)-like proteins, Bacterial Micro-Compartment (BMC) domain; Region: BMC_CcmK_like; cd07045
1247189006083	Hexamer interface [polypeptide binding]; other site
1247189006084	Hexagonal pore residue; other site
1247189006085	ethanolamine utilization protein EutQ; Provisional; Region: PRK15457
1247189006086	Ethanolamine utilisation protein and carboxysome structural protein domain family; Region: EutN_CcmL; cd01614
1247189006087	Hexamer/Pentamer interface [polypeptide binding]; other site
1247189006088	central pore; other site
1247189006089	ethanolamine utilization protein EutJ; Provisional; Region: PRK15080
1247189006090	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012
1247189006091	nucleotide binding site [chemical binding]; other site
1247189006092	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037
1247189006093	nucleotide binding site [chemical binding]; other site
1247189006094	Cobalamin adenosyltransferase; Region: Cob_adeno_trans; cl00920
1247189006095	Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454
1247189006096	1,3-propanediol dehydrogenase (PPD) catalyzes the reduction of 3-hydroxypropionaldehyde (3-HPA) to 1,3-propanediol in glycerol metabolism; Region: PDD; cd08180
1247189006097	putative active site [active]
1247189006098	metal binding site [ion binding]; metal-binding site
1247189006099	Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170
1247189006100	1,2-propanediol utilization protein U (PduU)/ethanolamine utilization protein S (EutS), Bacterial Micro-Compartment (BMC) domain; Region: BMC_PduU-EutS; cd07046
1247189006101	putative hexamer interface [polypeptide binding]; other site
1247189006102	putative hexagonal pore; other site
1247189006103	pyruvate formate lyase II activase; Provisional; Region: PRK10076
1247189006104	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cl15377
1247189006105	FeS/SAM binding site; other site
1247189006106	glycyl-radical enzyme activating protein family; Region: PFLE_PFLC; TIGR02494
1247189006107	glycyl radical enzyme, PFL2/glycerol dehydratase family; Region: PFL2-3; TIGR01774
1247189006108	Pyruvate formate lyase 2 and related enzymes; Region: PFL2_DhaB_BssA; cd01677
1247189006109	dimer interface [polypeptide binding]; other site
1247189006110	active site
1247189006111	glycine loop; other site
1247189006112	NAD-dependent aldehyde dehydrogenases [Energy production and conversion]; Region: PutA; COG1012
1247189006113	NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961
1247189006114	NAD(P) binding site [chemical binding]; other site
1247189006115	catalytic residues [active]
1247189006116	Carbon dioxide concentrating mechanism/carboxysome shell protein [Secondary metabolites biosynthesis, transport, and catabolism / Energy production and conversion]; Region: CcmK; COG4577
1247189006117	Carbon dioxide concentrating mechanism K (CcmK)-like proteins, Bacterial Micro-Compartment (BMC) domain; Region: BMC_CcmK_like; cd07045
1247189006118	Hexamer interface [polypeptide binding]; other site
1247189006119	Hexagonal pore residue; other site
1247189006120	Carbon dioxide concentrating mechanism/carboxysome shell protein [Secondary metabolites biosynthesis, transport, and catabolism / Energy production and conversion]; Region: CcmK; COG4577
1247189006121	Carbon dioxide concentrating mechanism K (CcmK)-like proteins, Bacterial Micro-Compartment (BMC) domain; Region: BMC_CcmK_like; cd07045
1247189006122	Hexamer interface [polypeptide binding]; other site
1247189006123	Hexagonal pore residue; other site
1247189006124	Winged helix DNA-binding domain; Region: HTH_34; pfam13601
1247189006125	Multidrug resistance efflux transporter; Region: EmrE; pfam13536
1247189006126	Carbon dioxide concentrating mechanism/carboxysome shell protein [Secondary metabolites biosynthesis, transport, and catabolism / Energy production and conversion]; Region: CcmK; COG4577
1247189006127	1,2-propanediol utilization protein A (PduA), Bacterial Micro-Compartment (BMC) domain; Region: BMC_PduA; cd07059
1247189006128	Hexamer interface [polypeptide binding]; other site
1247189006129	Putative hexagonal pore residue; other site
1247189006130	Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789
1247189006131	Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600
1247189006132	DNA binding residues [nucleotide binding]
1247189006133	GyrI-like small molecule binding domain; Region: GyrI-like; cl01368
1247189006134	Uncharacterized protein involved in cytokinesis, contains TGc (transglutaminase/protease-like) domain [Cell division and chromosome partitioning]; Region: CYK3; COG5279
1247189006135	Transglutaminase/protease-like homologues; Region: TGc; smart00460
1247189006136	Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285
1247189006137	nucleoside/Zn binding site; other site
1247189006138	dimer interface [polypeptide binding]; other site
1247189006139	catalytic motif [active]
1247189006140	Metal-dependent hydrolases of the beta-lactamase superfamily III [General function prediction only]; Region: ElaC; COG1234
1247189006141	Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220
1247189006142	Uncharacterized conserved protein [General function prediction only]; Region: BioY; COG1268
1247189006143	queuine tRNA-ribosyltransferase; Provisional; Region: tgt; PRK00112
1247189006144	Queuine/archaeosine tRNA-ribosyltransferase [Translation, ribosomal structure and biogenesis]; Region: Tgt; COG0343
1247189006145	Protein of unknown function (DUF975); Region: DUF975; pfam06161
1247189006146	Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153
1247189006147	metal binding site 2 [ion binding]; metal-binding site
1247189006148	putative DNA binding helix; other site
1247189006149	metal binding site 1 [ion binding]; metal-binding site
1247189006150	dimer interface [polypeptide binding]; other site
1247189006151	structural Zn2+ binding site [ion binding]; other site
1247189006152	Predicted CoA-binding protein [General function prediction only]; Region: COG1832
1247189006153	H3TH domains of structure-specific 5' nucleases (or flap endonuclease-1-like) involved in DNA replication, repair, and recombination; Region: H3TH_StructSpec-5'-nucleases; cl14815
1247189006154	inactive DEDDy 3'-5' exonuclease domain of Bacillus stearothermophilus DNA polymerase I and similar family-A DNA polymerases; Region: DNA_polA_I_Bacillus_like_exo; cd06140
1247189006155	DNA polymerase I - 3'-5' exonuclease and polymerase domains [DNA replication, recombination, and repair]; Region: PolA; COG0749
1247189006156	Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637
1247189006157	active site
1247189006158	DNA binding site [nucleotide binding]
1247189006159	catalytic site [active]
1247189006160	5'-3' exonuclease, N-terminal resolvase-like domain; Region: 5_3_exonuc_N; pfam02739
1247189006161	PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859
1247189006162	active site
1247189006163	metal binding site 1 [ion binding]; metal-binding site
1247189006164	putative 5' ssDNA interaction site; other site
1247189006165	metal binding site 3; metal-binding site
1247189006166	metal binding site 2 [ion binding]; metal-binding site
1247189006167	H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898
1247189006168	putative DNA binding site [nucleotide binding]; other site
1247189006169	putative metal binding site [ion binding]; other site
1247189006170	ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600
1247189006171	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1247189006172	dimer interface [polypeptide binding]; other site
1247189006173	conserved gate region; other site
1247189006174	putative PBP binding loops; other site
1247189006175	ABC-ATPase subunit interface; other site
1247189006176	ABC-type proline/glycine betaine transport systems, periplasmic components [Amino acid transport and metabolism]; Region: ProX; COG2113
1247189006177	Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069
1247189006178	ABC-type proline/glycine betaine transport system, ATPase component [Amino acid transport and metabolism]; Region: ProV; COG4175
1247189006179	ATP-binding cassette domain of the osmoprotectant proline/glycine betaine uptake system; Region: ABC_Pro_Gly_Betaine; cd03294
1247189006180	Walker A/P-loop; other site
1247189006181	ATP binding site [chemical binding]; other site
1247189006182	Q-loop/lid; other site
1247189006183	ABC transporter signature motif; other site
1247189006184	Walker B; other site
1247189006185	D-loop; other site
1247189006186	H-loop/switch region; other site
1247189006187	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354
1247189006188	Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase [Lipid metabolism / General function prediction only]; Region: LCB5; COG1597
1247189006189	Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781
1247189006190	putative L-ascorbate 6-phosphate lactonase; Provisional; Region: PRK11709
1247189006191	Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220
1247189006192	Transcriptional antiterminator [Transcription]; Region: BglG; COG3711
1247189006193	PRD domain; Region: PRD; pfam00874
1247189006194	PRD domain; Region: PRD; pfam00874
1247189006195	PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568
1247189006196	active site
1247189006197	P-loop; other site
1247189006198	phosphorylation site [posttranslational modification]
1247189006199	L-ribulose-5-phosphate 4-epimerase; Provisional; Region: araD; PRK13145
1247189006200	L-ribulose-5-phosphate 4-epimerase; Reviewed; Region: araD; PRK08193
1247189006201	intersubunit interface [polypeptide binding]; other site
1247189006202	active site
1247189006203	Zn2+ binding site [ion binding]; other site
1247189006204	putative L-xylulose 5-phosphate 3-epimerase; Reviewed; Region: PRK13210
1247189006205	AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cd00019
1247189006206	AP (apurinic/apyrimidinic) site pocket; other site
1247189006207	DNA interaction; other site
1247189006208	Metal-binding active site; metal-binding site
1247189006209	3-Keto-L-gulonate 6-phosphate decarboxylase (KGPDC) and D-arabino-3-hexulose-6-phosphate synthase (HPS). KGPDC catalyzes the formation of L-xylulose 5-phosphate and carbon dioxide from 3-keto-L-gulonate 6-phosphate as part of the anaerobic pathway for...; Region: KGPDC_HPS; cd04726
1247189006210	active site
1247189006211	dimer interface [polypeptide binding]; other site
1247189006212	magnesium binding site [ion binding]; other site
1247189006213	PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211
1247189006214	active site
1247189006215	phosphorylation site [posttranslational modification]
1247189006216	PTS_IIB_ascorbate: subunit IIB of enzyme II (EII) of the L-ascorbate-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is an L-ascorbate-specific permease with two cytoplasmic subunits (IIA and IIB) and a...; Region: PTS_IIB_ascorbate; cd05563
1247189006217	active site
1247189006218	P-loop; other site
1247189006219	phosphorylation site [posttranslational modification]
1247189006220	PTS system ascorbate-specific transporter subunit IIC; Reviewed; Region: PRK12997
1247189006221	leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390
1247189006222	catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812
1247189006223	HIGH motif; other site
1247189006224	Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603
1247189006225	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
1247189006226	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
1247189006227	active site
1247189006228	KMSKS motif; other site
1247189006229	Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958
1247189006230	tRNA binding surface [nucleotide binding]; other site
1247189006231	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
1247189006232	Cystathionine beta-lyases/cystathionine gamma-synthases [Amino acid transport and metabolism]; Region: MetC; COG0626
1247189006233	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
1247189006234	catalytic residue [active]
1247189006235	Helix-turn-helix domain; Region: HTH_38; pfam13936
1247189006236	Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826
1247189006237	Integrase core domain; Region: rve; pfam00665
1247189006238	Transposase; Region: HTH_Tnp_1; pfam01527
1247189006239	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963
1247189006240	HTH-like domain; Region: HTH_21; pfam13276
1247189006241	Integrase core domain; Region: rve; pfam00665
1247189006242	DDE domain; Region: DDE_Tnp_IS240; pfam13610
1247189006243	Integrase core domain; Region: rve_3; pfam13683
1247189006244	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
1247189006245	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
1247189006246	ATP-binding cassette domain of multidrug resistance protein-like transporters; Region: ABCC_MRP_Like; cd03228
1247189006247	Walker A/P-loop; other site
1247189006248	ATP binding site [chemical binding]; other site
1247189006249	Q-loop/lid; other site
1247189006250	ABC transporter signature motif; other site
1247189006251	Walker B; other site
1247189006252	D-loop; other site
1247189006253	H-loop/switch region; other site
1247189006254	Superfamily of activating enzymes (E1) of the ubiquitin-like proteins. This family includes classical ubiquitin-activating enzymes E1, ubiquitin-like (ubl) activating enzymes and other mechanistic homologes, like MoeB, Thif1 and others. The common...; Region: E1_enzyme_family; cd01483
1247189006255	ATP binding site [chemical binding]; other site
1247189006256	substrate interface [chemical binding]; other site
1247189006257	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
1247189006258	Transposase DDE domain; Region: DDE_Tnp_1_3; pfam13612
1247189006259	Thiol-activated cytolysin; Region: Thiol_cytolysin; pfam01289
1247189006260	Thiol-activated cytolysin; Region: Thiol_cytolysin; pfam01289
1247189006261	Bacterial periplasmic substrate-binding proteins; Region: PBPb; smart00062
1247189006262	Nicotine adenine dinucleotide glycohydrolase (NADase); Region: NADase_NGA; pfam07461
1247189006263	Nicotine adenine dinucleotide glycohydrolase (NADase); Region: NADase_NGA; pfam07461
1247189006264	transcription antitermination protein NusG; Validated; Region: nusG; PRK05609
1247189006265	Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891
1247189006266	putative homodimer interface [polypeptide binding]; other site
1247189006267	NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091
1247189006268	heterodimer interface [polypeptide binding]; other site
1247189006269	homodimer interface [polypeptide binding]; other site
1247189006270	Preprotein translocase subunit SecE [Intracellular trafficking and secretion]; Region: SecE; COG0690
1247189006271	Transglycosylase; Region: Transgly; pfam00912
1247189006272	penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074
1247189006273	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905
1247189006274	YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448
1247189006275	homotrimer interaction site [polypeptide binding]; other site
1247189006276	putative active site [active]
1247189006277	Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564
1247189006278	Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869
1247189006279	active site
1247189006280	Predicted membrane protein [Function unknown]; Region: COG4640
1247189006281	Dipeptidase [Amino acid transport and metabolism]; Region: PepD; COG4690
1247189006282	MutT homolog-1 (MTH1) is a member of the Nudix hydrolase superfamily. MTH1, the mammalian counterpart of MutT, hydrolyzes oxidized purine nucleoside triphosphates, such as 8-oxo-dGTP and 2-hydroxy-ATP, to monophosphates, thereby preventing the...; Region: MTH1; cd03427
1247189006283	putative active site [active]
1247189006284	nucleotide binding site [chemical binding]; other site
1247189006285	nudix motif; other site
1247189006286	putative metal binding site [ion binding]; other site
1247189006287	chaperonin GroEL; Reviewed; Region: groEL; PRK12849
1247189006288	GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344
1247189006289	ring oligomerisation interface [polypeptide binding]; other site
1247189006290	ATP/Mg binding site [chemical binding]; other site
1247189006291	stacking interactions; other site
1247189006292	hinge regions; other site
1247189006293	Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320
1247189006294	oligomerisation interface [polypeptide binding]; other site
1247189006295	mobile loop; other site
1247189006296	roof hairpin; other site
1247189006297	ATP-binding subunits of Clp protease and DnaK/DnaJ chaperones [Posttranslational modification, protein turnover, chaperones]; Region: clpA; COG0542
1247189006298	Clp amino terminal domain; Region: Clp_N; pfam02861
1247189006299	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1247189006300	Walker A motif; other site
1247189006301	ATP binding site [chemical binding]; other site
1247189006302	Walker B motif; other site
1247189006303	arginine finger; other site
1247189006304	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1247189006305	Walker A motif; other site
1247189006306	ATP binding site [chemical binding]; other site
1247189006307	Walker B motif; other site
1247189006308	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431
1247189006309	Transcriptional repressor of class III stress genes [Transcription]; Region: CtsR; COG4463
1247189006310	Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea.  CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458
1247189006311	Amidohydrolase; Region: Amidohydro_2; pfam04909
1247189006312	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
1247189006313	Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751
1247189006314	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3666
1247189006315	peroxiredoxin; Region: AhpC; TIGR03137
1247189006316	Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015
1247189006317	dimer interface [polypeptide binding]; other site
1247189006318	decamer (pentamer of dimers) interface [polypeptide binding]; other site
1247189006319	catalytic triad [active]
1247189006320	peroxidatic and resolving cysteines [active]
1247189006321	alkyl hydroperoxide reductase subunit F; Provisional; Region: PRK15317
1247189006322	Alkyl hydroperoxide reductase F subunit (AhpF) N-terminal domain (NTD) family, N-terminal TRX-fold subdomain; AhpF is a homodimeric flavoenzyme which catalyzes the NADH-dependent reduction of the peroxiredoxin AhpC, which in turn catalyzes the reduction...; Region: AhpF_NTD_N; cd02974
1247189006323	catalytic residue [active]
1247189006324	TRX-GRX-like family, Alkyl hydroperoxide reductase F subunit (AhpF) N-terminal domain (NTD) subfamily, C-terminal TRX-fold subdomain; AhpF is a homodimeric flavoenzyme which catalyzes the NADH-dependent reduction of the peroxiredoxin AhpC, which then...; Region: AhpF_NTD_C; cd03026
1247189006325	catalytic residues [active]
1247189006326	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
1247189006327	imidazolonepropionase; Validated; Region: PRK09356
1247189006328	Imidazolonepropionase/imidazolone-5-propionate hydrolase (Imidazolone-5PH) catalyzes the third step in the histidine degradation pathway, the hydrolysis of (S)-3-(5-oxo-4,5-dihydro-3H-imidazol-4-yl)propanoate to N-formimidoyl-L-glutamate. In bacteria; Region: Imidazolone-5PH; cd01296
1247189006329	active site
1247189006330	urocanate hydratase; Provisional; Region: PRK05414
1247189006331	Glutamate formiminotransferase [Amino acid transport and metabolism]; Region: COG3643
1247189006332	Formiminotransferase domain, N-terminal subdomain; Region: FTCD_N; pfam07837
1247189006333	Formiminotransferase domain; Region: FTCD; pfam02971
1247189006334	Methenyl tetrahydrofolate cyclohydrolase [Amino acid transport and metabolism]; Region: COG3404
1247189006335	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
1247189006336	Formyltetrahydrofolate synthetase (FTHFS) catalyzes the ATP-dependent activation of formate ion via its addition to the N10 position of tetrahydrofolate. FTHFS is a highly expressed key enzyme in both the Wood-Ljungdahl pathway of autotrophic CO2...; Region: FTHFS; cd00477
1247189006337	Cesium cation binding sites [ion binding]; other site
1247189006338	Potassium binding sites [ion binding]; other site
1247189006339	HutD; Region: HutD; cl01532
1247189006340	amino acid transporter; Region: 2A0306; TIGR00909
1247189006341	Phenylalanine ammonia-lyase (PAL) and histidine ammonia-lyase (HAL); Region: PAL-HAL; cd00332
1247189006342	active sites [active]
1247189006343	tetramer interface [polypeptide binding]; other site
1247189006344	formimidoylglutamase; Provisional; Region: PRK13775
1247189006345	Formimidoylglutamase or HutE; Region: Formimidoylglutamase; cd09988
1247189006346	putative active site [active]
1247189006347	putative metal binding site [ion binding]; other site
1247189006348	DNA-binding transcriptional activator of the SARP family [Signal transduction mechanisms]; Region: DnrI; COG3629
1247189006349	Predicted ATPase [General function prediction only]; Region: COG3899
1247189006350	AAA ATPase domain; Region: AAA_16; pfam13191
1247189006351	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429
1247189006352	binding surface
1247189006353	TPR motif; other site
1247189006354	Protein of unknown function (DUF3626); Region: DUF3626; pfam12294
1247189006355	Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425
1247189006356	rRNA interaction site [nucleotide binding]; other site
1247189006357	S8 interaction site; other site
1247189006358	putative laminin-1 binding site; other site
1247189006359	elongation factor Ts; Provisional; Region: tsf; PRK09377
1247189006360	UBA/TS-N domain; Region: UBA; pfam00627
1247189006361	Elongation factor TS; Region: EF_TS; pfam00889
1247189006362	Elongation factor TS; Region: EF_TS; pfam00889
1247189006363	Predicted metalloendopeptidase [Posttranslational modification, protein turnover, chaperones]; Region: PepO; COG3590
1247189006364	Peptidase family M13 includes neprilysin, endothelin-converting enzyme I; Region: M13; cd08662
1247189006365	active site
1247189006366	Zn binding site [ion binding]; other site
1247189006367	alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403
1247189006368	Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333
1247189006369	Ca binding site [ion binding]; other site
1247189006370	active site
1247189006371	catalytic site [active]
1247189006372	Domain of unknown function (DUF3459); Region: DUF3459; pfam11941
1247189006373	PTS system, trehalose-specific IIBC component; Region: PTS-IIBC-Tre; TIGR01992
1247189006374	PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212
1247189006375	active site turn [active]
1247189006376	phosphorylation site [posttranslational modification]
1247189006377	Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263
1247189006378	Phosphotransferase system IIA components [Carbohydrate transport and metabolism]; Region: NagE; COG2190
1247189006379	HPr interaction site; other site
1247189006380	glycerol kinase (GK) interaction site [polypeptide binding]; other site
1247189006381	active site
1247189006382	phosphorylation site [posttranslational modification]
1247189006383	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
1247189006384	DNA-binding site [nucleotide binding]; DNA binding site
1247189006385	trehalose operon repressor, B. subtilis-type; Region: trehalos_R_Bsub; TIGR02404
1247189006386	UTRA domain; Region: UTRA; pfam07702
1247189006387	Predicted transcriptional regulators [Transcription]; Region: COG1733
1247189006388	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
1247189006389	dimerization interface [polypeptide binding]; other site
1247189006390	putative DNA binding site [nucleotide binding]; other site
1247189006391	putative Zn2+ binding site [ion binding]; other site
1247189006392	This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_12; cd07255
1247189006393	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
1247189006394	putative metal binding site [ion binding]; other site
1247189006395	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3022
1247189006396	anaerobic ribonucleotide reductase-activating protein; Provisional; Region: nrdG; cl15804
1247189006397	anaerobic ribonucleotide reductase-activating protein; Provisional; Region: nrdG; cl15804
1247189006398	4Fe-4S single cluster domain; Region: Fer4_12; pfam13353
1247189006399	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
1247189006400	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
1247189006401	Coenzyme A binding pocket [chemical binding]; other site
1247189006402	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
1247189006403	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
1247189006404	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
1247189006405	anaerobic ribonucleoside triphosphate reductase; Provisional; Region: PRK09263
1247189006406	ATP cone domain; Region: ATP-cone; pfam03477
1247189006407	Class III ribonucleotide reductase; Region: RNR_III; cd01675
1247189006408	effector binding site; other site
1247189006409	active site
1247189006410	Zn binding site [ion binding]; other site
1247189006411	glycine loop; other site
1247189006412	Predicted membrane protein (DUF2079); Region: DUF2079; pfam09852
1247189006413	hypothetical protein; Provisional; Region: PRK13678
1247189006414	Holliday junction resolvase-like protein; Reviewed; Region: PRK00109
1247189006415	hypothetical protein; Provisional; Region: PRK05473
1247189006416	Arsenate Reductase (ArsC) family, Spx subfamily; Spx is a unique RNA polymerase (RNAP)-binding protein present in bacilli and some mollicutes. It inhibits transcription by binding to the C-terminal domain of the alpha subunit of RNAP, disrupting complex...; Region: ArsC_Spx; cd03032
1247189006417	ArsC family; Region: ArsC; pfam03960
1247189006418	putative catalytic residues [active]
1247189006419	thiol/disulfide switch; other site
1247189006420	recombinase A; Provisional; Region: recA; PRK09354
1247189006421	RecA is a  bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response.  RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983
1247189006422	hexamer interface [polypeptide binding]; other site
1247189006423	Walker A motif; other site
1247189006424	ATP binding site [chemical binding]; other site
1247189006425	Walker B motif; other site
1247189006426	competence damage-inducible protein A; Provisional; Region: PRK00549
1247189006427	Competence-damaged protein. CinA is the first gene in the competence- inducible (cin) operon and is thought to be specifically required at some stage in the process of transformation. This domain is closely related to a domain, found in a variety of...; Region: cinA; cd00885
1247189006428	putative MPT binding site; other site
1247189006429	Uncharacterized protein (competence- and mitomycin-induced) [General function prediction only]; Region: CinA; COG1546
1247189006430	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
1247189006431	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587
1247189006432	active site
1247189006433	Methyladenine glycosylase; Region: Adenine_glyco; pfam03352
1247189006434	Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116
1247189006435	RuvA N terminal domain; Region: RuvA_N; pfam01330
1247189006436	RuvA, C-terminal domain; Region: RuvA_C; pfam07499
1247189006437	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1247189006438	Major Facilitator Superfamily; Region: MFS_1; pfam07690
1247189006439	putative substrate translocation pore; other site
1247189006440	DNA mismatch repair protein; Reviewed; Region: mutL; PRK00095
1247189006441	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1247189006442	ATP binding site [chemical binding]; other site
1247189006443	Mg2+ binding site [ion binding]; other site
1247189006444	G-X-G motif; other site
1247189006445	MutL_Trans: transducer domain, having a ribosomal S5 domain 2-like fold, conserved in the C-terminal domain of DNA mismatch repair (MutL/MLH1/PMS2) family. This transducer domain is homologous to the second domain of the DNA gyrase B subunit, which is...; Region: MutL_Trans; cd00782
1247189006446	ATP binding site [chemical binding]; other site
1247189006447	MutL C terminal dimerisation domain; Region: MutL_C; pfam08676
1247189006448	phiLC3 phage and phage-related integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes various bacterial (mainly gram positive) and phage integrases, including those similar to Lactococcus...; Region: INT_phiLC3_C; cd01189
1247189006449	Int/Topo IB signature motif; other site
1247189006450	Protein of unknown function (DUF3644); Region: DUF3644; pfam12358
1247189006451	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
1247189006452	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
1247189006453	non-specific DNA binding site [nucleotide binding]; other site
1247189006454	salt bridge; other site
1247189006455	sequence-specific DNA binding site [nucleotide binding]; other site
1247189006456	Predicted transcriptional regulator [Transcription]; Region: COG2932
1247189006457	Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529
1247189006458	Catalytic site [active]
1247189006459	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
1247189006460	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
1247189006461	non-specific DNA binding site [nucleotide binding]; other site
1247189006462	salt bridge; other site
1247189006463	sequence-specific DNA binding site [nucleotide binding]; other site
1247189006464	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl17200
1247189006465	non-specific DNA binding site [nucleotide binding]; other site
1247189006466	salt bridge; other site
1247189006467	sequence-specific DNA binding site [nucleotide binding]; other site
1247189006468	Prophage antirepressor [Transcription]; Region: COG3617
1247189006469	BRO family, N-terminal domain; Region: Bro-N; smart01040
1247189006470	Prophage antirepressor [Transcription]; Region: COG3617
1247189006471	BRO family, N-terminal domain; Region: Bro-N; smart01040
1247189006472	Uncharacterized phage-encoded protein [Function unknown]; Region: COG3646
1247189006473	Phage regulatory protein Rha (Phage_pRha); Region: Phage_pRha; pfam09669
1247189006474	Protein of unknown function (DUF1211); Region: DUF1211; cl01421
1247189006475	YbaK-like.  The YbaK family of deacylase domains includes the INS amino acid-editing domain of  the bacterial class II prolyl tRNA synthetase (ProRS), and it's trans-acting homologs, YbaK, ProX, and PrdX. The primary function of INS is to hydrolyze...; Region: YbaK_like; cl00022
1247189006476	putative deacylase active site [active]
1247189006477	YbaK-like.  The YbaK family of deacylase domains includes the INS amino acid-editing domain of  the bacterial class II prolyl tRNA synthetase (ProRS), and it's trans-acting homologs, YbaK, ProX, and PrdX. The primary function of INS is to hydrolyze...; Region: YbaK_like; cl00022
1247189006478	Cro/C1-type HTH DNA-binding domain; Region: HTH_26; pfam13443
1247189006479	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
1247189006480	sequence-specific DNA binding site [nucleotide binding]; other site
1247189006481	salt bridge; other site
1247189006482	Prophage antirepressor [Transcription]; Region: COG3617
1247189006483	BRO family, N-terminal domain; Region: Bro-N; smart01040
1247189006484	Primase C terminal 1 (PriCT-1); Region: PriCT_1; pfam08708
1247189006485	Virulence-associated protein E; Region: VirE; pfam05272
1247189006486	phage transcriptional regulator, ArpU family; Region: phage_arpU; TIGR01637
1247189006487	MutS domain III; Region: MutS_III; pfam05192
1247189006488	MutS domain V; Region: MutS_V; pfam00488
1247189006489	Walker A/P-loop; other site
1247189006490	ATP binding site [chemical binding]; other site
1247189006491	Q-loop/lid; other site
1247189006492	ABC transporter signature motif; other site
1247189006493	Walker B; other site
1247189006494	D-loop; other site
1247189006495	H-loop/switch region; other site
1247189006496	MutS domain I; Region: MutS_I; pfam01624
1247189006497	MutS domain II; Region: MutS_II; pfam05188
1247189006498	MutS domain III; Region: MutS_III; pfam05192
1247189006499	Protein of unknown function (DUF964); Region: DUF964; cl01483
1247189006500	Arginine repressor, DNA binding domain; Region: Arg_repressor; pfam01316
1247189006501	arginine repressor; Region: argR_whole; TIGR01529
1247189006502	Arginine repressor, C-terminal domain; Region: Arg_repressor_C; pfam02863
1247189006503	arginyl-tRNA synthetase; Reviewed; Region: PRK12451
1247189006504	Arginyl tRNA synthetase N terminal dom; Region: Arg_tRNA_synt_N; smart01016
1247189006505	catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671
1247189006506	active site
1247189006507	HIGH motif; other site
1247189006508	KMSK motif region; other site
1247189006509	Anticodon-binding domain of arginyl tRNA synthetases; Region: Anticodon_Ia_Arg; cd07956
1247189006510	tRNA binding surface [nucleotide binding]; other site
1247189006511	anticodon binding site; other site
1247189006512	ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488
1247189006513	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
1247189006514	ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122
1247189006515	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
1247189006516	ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488
1247189006517	ABC transporter; Region: ABC_tran_2; pfam12848
1247189006518	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1247189006519	Walker A/P-loop; other site
1247189006520	ATP binding site [chemical binding]; other site
1247189006521	ABC transporter signature motif; other site
1247189006522	Uncharacterized conserved protein [Function unknown]; Region: COG1284
1247189006523	Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588
1247189006524	Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588
1247189006525	Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035
1247189006526	Uncharacterized conserved protein [Function unknown]; Region: COG1284
1247189006527	Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588
1247189006528	Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035
1247189006529	Uncharacterized conserved protein [Function unknown]; Region: COG1284
1247189006530	Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588
1247189006531	Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588
1247189006532	Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035
1247189006533	aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476
1247189006534	EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317
1247189006535	dimer interface [polypeptide binding]; other site
1247189006536	anticodon binding site; other site
1247189006537	Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777
1247189006538	homodimer interface [polypeptide binding]; other site
1247189006539	motif 1; other site
1247189006540	active site
1247189006541	motif 2; other site
1247189006542	GAD domain; Region: GAD; pfam02938
1247189006543	Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777
1247189006544	motif 3; other site
1247189006545	histidyl-tRNA synthetase; Reviewed; Region: hisS; PRK00037
1247189006546	Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773
1247189006547	dimer interface [polypeptide binding]; other site
1247189006548	motif 1; other site
1247189006549	active site
1247189006550	motif 2; other site
1247189006551	HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859
1247189006552	anticodon binding site; other site
1247189006553	50S ribosomal protein L32; Validated; Region: rpmF; PRK01110
1247189006554	50S ribosomal protein L33; Validated; Region: rpmG; PRK00595
1247189006555	Predicted membrane protein [Function unknown]; Region: COG2035
1247189006556	Thioredoxin domain; Region: Thioredoxin_3; pfam13192
1247189006557	Coenzyme A pyrophosphatase (CoAse), a member of the Nudix hydrolase superfamily, functions to catalyze the elimination of oxidized inactive CoA, which can inhibit CoA-utilizing enzymes. The need of CoAses mainly arises under conditions of oxidative...; Region: CoAse; cd03426
1247189006558	putative active site [active]
1247189006559	putative CoA binding site [chemical binding]; other site
1247189006560	nudix motif; other site
1247189006561	metal binding site [ion binding]; metal-binding site
1247189006562	Predicted transcriptional regulators [Transcription]; Region: COG1695
1247189006563	Transcriptional regulator PadR-like family; Region: PadR; pfam03551
1247189006564	Predicted membrane protein [Function unknown]; Region: COG4709
1247189006565	Domain of unknown function (DUF4097); Region: DUF4097; pfam13349
1247189006566	Predicted membrane protein [Function unknown]; Region: COG1511
1247189006567	YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061
1247189006568	YhgE/Pip C-terminal domain; Region: pip_yhgE_Cterm; TIGR03062
1247189006569	probable dihydroxyacetone kinase regulator; Region: DHAK_reg; TIGR02366
1247189006570	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
1247189006571	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
1247189006572	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3666
1247189006573	30S ribosomal protein S4; Validated; Region: rpsD; PRK05327
1247189006574	30S ribosomal protein S4; Validated; Region: rpsD; PRK05327
1247189006575	Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163
1247189006576	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
1247189006577	RNA binding surface [nucleotide binding]; other site
1247189006578	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; pfam13808
1247189006579	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
1247189006580	Transposase [DNA replication, recombination, and repair]; Region: COG5433
1247189006581	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
1247189006582	non-specific DNA binding site [nucleotide binding]; other site
1247189006583	salt bridge; other site
1247189006584	sequence-specific DNA binding site [nucleotide binding]; other site
1247189006585	Uncharacterized protein conserved in bacteria [Function unknown]; Region: Veg; COG4466
1247189006586	replicative DNA helicase; Provisional; Region: PRK05748
1247189006587	DnaB-like helicase N terminal domain; Region: DnaB; pfam00772
1247189006588	DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the  chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984
1247189006589	Walker A motif; other site
1247189006590	ATP binding site [chemical binding]; other site
1247189006591	Walker B motif; other site
1247189006592	DNA binding loops [nucleotide binding]
1247189006593	Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948
1247189006594	50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137
1247189006595	Predicted signaling protein consisting of a modified GGDEF domain and a DHH domain [Signal transduction mechanisms]; Region: COG3887
1247189006596	DHH family; Region: DHH; pfam01368
1247189006597	DHHA1 domain; Region: DHHA1; pfam02272
1247189006598	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; pfam13808
1247189006599	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
1247189006600	Transposase [DNA replication, recombination, and repair]; Region: COG5433
1247189006601	tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA; Validated; Region: PRK05192
1247189006602	tRNA:m(5)U-54 methyltransferase; Region: gid_trmFO; TIGR00137
1247189006603	GidA associated domain 3; Region: GIDA_assoc_3; pfam13932
1247189006604	Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447
1247189006605	nudix motif; other site
1247189006606	MarC family integral membrane protein; Region: MarC; cl00919
1247189006607	MarC family integral membrane protein; Region: MarC; pfam01914
1247189006608	Predicted tRNA(5-methylaminomethyl-2-thiouridylate) methyltransferase, contains the PP-loop ATPase domain [Translation, ribosomal structure and biogenesis]; Region: TrmU; COG0482
1247189006609	tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998
1247189006610	L-serine dehydratase, iron-sulfur-dependent, beta subunit; Region: sda_beta; TIGR00719
1247189006611	Serine dehydratase beta chain; Region: SDH_beta; pfam03315
1247189006612	C-terminal ACT domain of the L-serine dehydratase (LSD), iron-sulfur-dependent, beta subunit; Region: ACT_LSD; cd04903
1247189006613	putative L-serine binding site [chemical binding]; other site
1247189006614	Serine dehydratase alpha chain; Region: SDH_alpha; cl12120
1247189006615	L-serine deaminase [Amino acid transport and metabolism]; Region: SdaA; COG1760
1247189006616	Predicted phosphatases [General function prediction only]; Region: Gph; COG0546
1247189006617	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
1247189006618	active site
1247189006619	motif I; other site
1247189006620	motif II; other site
1247189006621	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
1247189006622	N-acetyl-D-glucosamine binding site [chemical binding]; other site
1247189006623	catalytic residue [active]
1247189006624	ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619
1247189006625	cobalt transporter ATP-binding subunit; Provisional; Region: cbiO; PRK13649
1247189006626	First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225
1247189006627	Walker A/P-loop; other site
1247189006628	ATP binding site [chemical binding]; other site
1247189006629	Q-loop/lid; other site
1247189006630	ABC transporter signature motif; other site
1247189006631	Walker B; other site
1247189006632	D-loop; other site
1247189006633	H-loop/switch region; other site
1247189006634	cobalt transporter ATP-binding subunit; Provisional; Region: cbiO; PRK13650
1247189006635	First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225
1247189006636	Walker A/P-loop; other site
1247189006637	ATP binding site [chemical binding]; other site
1247189006638	Q-loop/lid; other site
1247189006639	ABC transporter signature motif; other site
1247189006640	Walker B; other site
1247189006641	D-loop; other site
1247189006642	H-loop/switch region; other site
1247189006643	CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453
1247189006644	Predicted transcriptional regulator contains Xre-like HTH domain [Function unknown]; Region: COG1426
1247189006645	Helix-turn-helix domain; Region: HTH_25; pfam13413
1247189006646	Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612
1247189006647	Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675
1247189006648	Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193
1247189006649	Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612
1247189006650	Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193
1247189006651	S4-like RNA binding protein [Replication, recombination, and repair]; Region: COG2501
1247189006652	recF protein; Region: recf; TIGR00611
1247189006653	ATP-binding cassette domain of RecF; Region: ABC_RecF; cd03242
1247189006654	Walker A/P-loop; other site
1247189006655	ATP binding site [chemical binding]; other site
1247189006656	Q-loop/lid; other site
1247189006657	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1247189006658	ABC transporter signature motif; other site
1247189006659	Walker B; other site
1247189006660	D-loop; other site
1247189006661	H-loop/switch region; other site
1247189006662	Putative glucose uptake permease [Carbohydrate transport and metabolism]; Region: GlcU; COG4975
1247189006663	inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567
1247189006664	TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186
1247189006665	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein.  IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a...; Region: CBS_pair_IMPDH; cd04601
1247189006666	IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381
1247189006667	active site
1247189006668	tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282
1247189006669	catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806
1247189006670	active site
1247189006671	HIGH motif; other site
1247189006672	dimer interface [polypeptide binding]; other site
1247189006673	KMSKS motif; other site
1247189006674	Uncharacterized conserved protein [Function unknown]; Region: COG1284
1247189006675	Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588
1247189006676	Uncharacterized conserved protein [Function unknown]; Region: COG1284
1247189006677	Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588
1247189006678	Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035
1247189006679	ABC transporter ATP-binding protein; Provisional; Region: PRK15064
1247189006680	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
1247189006681	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
1247189006682	ABC transporter; Region: ABC_tran_2; pfam12848
1247189006683	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
1247189006684	Predicted membrane protein [Function unknown]; Region: COG4485
1247189006685	Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826
1247189006686	Helix-turn-helix domain; Region: HTH_38; pfam13936
1247189006687	Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826
1247189006688	Integrase core domain; Region: rve; pfam00665
1247189006689	rRNA large subunit methyltransferase; Provisional; Region: PRK00103
1247189006690	Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365
1247189006691	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
1247189006692	protein binding site [polypeptide binding]; other site
1247189006693	ParB-like nuclease domain; Region: ParBc; pfam02195
1247189006694	KorB domain; Region: KorB; pfam08535