-- dump date 20140620_081737 -- class Genbank::CDS -- table cds_note -- id note YP_002995770.1 binds to the dnaA-box as an ATP-bound complex at the origin of replication during the initiation of chromosomal replication; can also affect transcription of multiple genes including itself. YP_002995771.1 binds the polymerase to DNA and acts as a sliding clamp YP_002995772.1 similar to hypothetical cytosolic protein [Streptococcus pyogenes MGAS10394] YP_002995773.1 similar to hypothetical protein gbs0005 [Streptococcus agalactiae NEM316] YP_002995774.1 translation-associated GTPase; the crystal structure of the Haemophilus influenzae YchF protein showed similarity to the yeast structure (PDB: 1NI3); fluorescence spectroscopy revealed nucleic acid binding; the yeast protein YBR025c interacts with the translation elongation factor eEF1 YP_002995775.1 Enables the recycling of peptidyl-tRNAs produced at termination of translation YP_002995776.1 similar to transcription-repair coupling factor [Streptococcus pyogenes SSI-1] YP_002995777.1 similar to polysaccharide biosynthesis family protein [Streptococcus equi subsp. zooepidemicus MGCS10565] YP_002995778.1 similar to S4 domain protein [Streptococcus agalactiae 2603V/R] YP_002995779.1 similar to cell division protein [Streptococcus pyogenes MGAS8232] YP_002995780.1 similar to hypothetical protein M6 Spy0009 [Streptococcus pyogenes MGAS10394] YP_002995781.1 similar to beta-lactamase [Streptococcus pyogenes MGAS2096] YP_002995782.1 similar to tRNA(Ile)-lysidine synthetase [Streptococcus pyogenes MGAS10394] YP_002995783.1 similar to hypoxanthine- guaninephosphoribosyltransferase [Streptococcus pyogenesMGAS8232] YP_002995784.1 similar to cell division protein [Streptococcus pyogenes MGAS6180] YP_002995785.1 similar to amino acid permease [Streptococcus pyogenes MGAS10394] YP_002995786.1 similar to secreted protein [Streptococcus pyogenes MGAS2096] YP_002995787.1 catalyzes the formation of 5-phospho-alpha-D-ribose 1-phosphate from D-ribose 5-phosphate and ATP YP_002995788.1 involved in DNA repair and RecFOR pathway recombination; RecFOR proteins displace ssDNA-binding protein and facilitate the production of RecA-coated ssDNA YP_002995789.1 involved in acylation of glycerol-3-phosphate to form 1-acyl-glycerol-3 phosphate for use in phospholipid biosynthesis; functions with PlsY YP_002995790.1 carries the fatty acid chain in fatty acid biosynthesis YP_002995791.1 catalyzes the formation of (S)-2-(5-amino-1-(5-phospho-D-ribosyl)imidazole-4- carboxamido)succinate from 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate and L-aspartate in purine biosynthesis; SAICAR synthase YP_002995792.1 similar to phosphoribosyl formyl glycinamidine synthase [Streptococcus pyogenes MGAS2096] YP_002995793.1 Catalyzes first step of the de novo purine nucleotide biosynthetic pathway YP_002995794.1 catalyzes the formation of 1-(5-phosphoribosyl)-5-aminoimidazole from 2-(formamido)-N1-(5-phosphoribosyl)acetamidine and ATP in purine biosynthesis YP_002995795.1 glycinamide ribonucleotide transformylase; GAR Tfase; catalyzes the synthesis of 5'-phosphoribosylformylglycinamide from 5'-phosphoribosylglycinamide and 10-formyltetrahydrofolate; PurN requires formyl folate for the reaction unlike PurT which uses formate YP_002995796.1 similar to vanZ protein [Streptococcus pneumoniae TIGR4] YP_002995797.1 involved in de novo purine biosynthesis YP_002995798.1 similar to autolysin [Streptococcus pyogenes MGAS5005] YP_002995799.1 catalyzes the formation of N(1)-(5-phospho-D-ribosyl)glycinamide from 5-phospho-D-ribosylamine and glycine in purine biosynthesis YP_002995800.1 similar to phosphoribosyl carboxyaminoimidazole (NCAIR) mutase [Streptococcus suis 98HAH33] YP_002995801.1 With PurE catalyzes the conversion of aminoimidazole ribonucleotide to carboxyaminoimidazole ribonucleotide in the de novo purine nucleotide biosynthetic pathway YP_002995802.1 similar to hypothetical protein SGO 2086 [Streptococcus gordonii str. Challis substr. CH1] YP_002995803.1 Catalyzes two discrete reactions in the de novo synthesis of purines: the cleavage of adenylosuccinate and succinylaminoimidazole carboxamide ribotide YP_002995804.1 similar to transcriptional regulator [Streptococcus pyogenes MGAS10750] YP_002995805.1 promotes strand exchange during homologous recombination; RuvAB complex promotes branch migration; RuvABC complex scans the DNA during branch migration and resolves Holliday junctions at consensus sequences; forms hexameric rings around opposite DNA arms; requires ATP for branch migration and orientation of RuvAB complex determines direction of migration YP_002995806.1 similar to protein tyrosine phosphatase [Streptococcus pyogenes MGAS10270] YP_002995807.1 similar to hypothetical membrane associated protein [Streptococcus pyogenes MGAS2096] YP_002995808.1 similar to acyltransferase family [Streptococcus pyogenes MGAS6180] YP_002995809.1 similar to alcohol dehydrogenase/acetaldehyde dehydrogenase (acetylating) [Streptococcus pyogenes MGAS5005] YP_002995810.1 similar to zinc-dependent eukaryotic ADH enzymes and distinct from fermentative ADHs YP_002995811.1 catalyzes the formation of L-threonine from O-phospho-L-homoserine YP_002995812.1 similar to Na+ driven multidrug efflux pump [Streptococcus pyogenes MGAS10394] YP_002995813.1 similar to transposase [Streptococcus pyogenes MGAS10394] YP_002995814.1 similar to transposase [Streptococcus pyogenes MGAS8232] YP_002995815.1 NusE; involved in assembly of the 30S subunit; in the ribosome, this protein is involved in the binding of tRNA; in Escherichia coli this protein was also found to be involved in transcription antitermination; NusB/S10 heterodimers bind boxA sequences in the leader RNA of rrn operons which is required for antitermination; binding of NusB/S10 to boxA nucleates assembly of the antitermination complex YP_002995816.1 binds directly near the 3' end of the 23S rRNA, where it nucleates assembly of the 50S subunit; essential for peptidyltransferase activity; mutations in this gene confer resistance to tiamulin YP_002995817.1 L4 is important during the early stages of 50S assembly; it initially binds near the 5' end of the 23S rRNA YP_002995818.1 binds third domain of 23S rRNA and protein L29; part of exit tunnel YP_002995819.1 one of the primary rRNA-binding proteins; required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation YP_002995820.1 similar to SSU ribosomal protein S19P [Streptococcus pyogenes MGAS2096] YP_002995821.1 binds specifically to 23S rRNA during the early stages of 50S assembly; makes contact with all 6 domains of the 23S rRNA in the assembled 50S subunit and ribosome; mutations in this gene result in erythromycin resistance; located near peptidyl-transferase center YP_002995822.1 forms a complex with S10 and S14; binds the lower part of the 30S subunit head and the mRNA in the complete ribosome to position it for translation YP_002995823.1 located in the peptidyl transferase center and may be involved in peptidyl transferase activity; similar to archaeal L10e YP_002995824.1 one of the stabilizing components for the large ribosomal subunit YP_002995825.1 primary binding protein; helps mediate assembly; involved in translation fidelity YP_002995826.1 binds to the 23S rRNA between the centers for peptidyl transferase and GTPase YP_002995827.1 similar to 50S ribosomal protein L14 [Staphylococcus epidermidis ATCC 12228] YP_002995828.1 assembly initiator protein; binds to 5' end of 23S rRNA and nucleates assembly of the 50S; surrounds polypeptide exit tunnel YP_002995829.1 part of 50S and 5S/L5/L18/L25 subcomplex; contacts 5S rRNA and P site tRNA; forms a bridge to the 30S subunit in the ribosome by binding to S13 YP_002995830.1 located in the peptidyl transferase center and involved in assembly of 30S ribosome subunit; similar to what is observed with proteins L31 and L33, some proteins in this family contain CXXC motifs that are involved in zinc binding; if two copies are present in a genome, then the duplicated copy appears to have lost the zinc-binding motif and is instead regulated by zinc; the proteins in this group appear to contain the zinc-binding motif YP_002995831.1 binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit YP_002995832.1 ribosomal protein L6 appears to have arisen as a result of an ancient gene duplication as based on structural comparison of the Bacillus stearothermophilus protein; RNA-binding appears to be in the C-terminal domain; mutations in the L6 gene confer resistance to aminoglycoside antibiotics such as gentamicin and these occur in truncations of the C-terminal domain; it has been localized to a region between the base of the L7/L12 stalk and the central protuberance YP_002995833.1 binds 5S rRNA along with protein L5 and L25 YP_002995834.1 similar to conserved hypothetical protein [Listeria monocytogenes str. 4b H7858] YP_002995835.1 located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body; contacts S4 and S8; with S4 and S12 plays a role in translational accuracy; mutations in this gene result in spectinomycin resistance YP_002995836.1 similar to ribosomal protein [Streptococcus agalactiae CJB111] YP_002995837.1 L30 binds domain II of the 23S rRNA and the 5S rRNA; similar to eukaryotic protein L7 YP_002995838.1 late assembly protein YP_002995839.1 forms heterotrimeric complex in the membrane; in bacteria the complex consists of SecY which forms the channel pore and SecE and SecG; the SecG subunit is not essential; in bacteria translocation is driven via the SecA ATPase YP_002995840.1 similar to adenylate kinase Adk [Streptococcus equi subsp. zooepidemicus MGCS10565] YP_002995841.1 stimulates the activities of the other two initiation factors, IF-2 and IF-3 YP_002995842.1 smallest protein in the large subunit; similar to what is found with protein L31 and L33 several bacterial genomes contain paralogs which may be regulated by zinc; the protein from Thermus thermophilus has a zinc-binding motif and contains a bound zinc ion; the proteins in this group have the motif YP_002995843.1 located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA; makes contact with the large subunit via RNA-protein interactions and via protein-protein interactions with L5; contacts P-site tRNA YP_002995844.1 located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA; forms part of the Shine-Dalgarno cleft in the 70S ribosome; interacts with S7 and S18 and IF-3 YP_002995845.1 catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Dimerization of the alpha subunit is the first step in the sequential assembly of subunits to form the holoenzyme YP_002995846.1 is a component of the macrolide binding site in the peptidyl transferase center YP_002995847.1 similar to transposase [Streptococcus pyogenes MGAS10394] YP_002995848.1 similar to transposase [Streptococcus pyogenes MGAS10270] YP_002995849.1 similar to nudix hydrolase [Streptococcus equi subsp. zooepidemicus MGCS10565] YP_002995850.1 catalyzes the formation of dimethylmenaquinone from 1,4-dihydroxy-2-naphthoate and octaprenyl diphosphate YP_002995851.1 similar to hypothetical protein gbs1788 [Streptococcus agalactiae NEM316] YP_002995852.1 similar to cytochrome d ubiquinol oxidase subunit II [Streptococcus agalactiae A909] YP_002995853.1 similar to cytochrome d ubiquinol oxidase subunit II [Streptococcus agalactiae 2603V/R] YP_002995854.1 similar to hypothetical protein gbs1785 [Streptococcus agalactiae NEM316] YP_002995855.1 similar to hypothetical protein gbs1784 [Streptococcus agalactiae NEM316] YP_002995856.1 similar to hypothetical protein gbs1783 [Streptococcus agalactiae NEM316] YP_002995857.1 An essential enzyme in the nonmevalonate pathway of isopentenyl diphosphate and dimethylallyl diphosphate biosynthesis YP_002995858.1 similar to repressor protein [Streptococcus pyogenes MGAS315] YP_002995859.1 similar to ABC transporter (ATP-binding protein) [Streptococcus pyogenes MGAS315] YP_002995860.1 similar to high-affinity zinc uptake system membrane protein znuB [Streptococcus pyogenes MGAS2096] YP_002995861.1 catalyzes the formation of tyrosyl-tRNA(Tyr) from tyrosine and tRNA(Tyr) YP_002995862.1 similar to multimodular transpeptidase-transglycosylase [Streptococcus pyogenes MGAS10394] YP_002995863.1 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates; beta subunit is part of the catalytic core which binds with a sigma factor to produce the holoenzyme YP_002995864.1 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Subunit beta' binds to sigma factor allowing it to bind to the -10 region of the promoter YP_002995865.1 similar to DNA binding protein [Streptococcus pyogenes MGAS8232] YP_002995866.1 similar to ComG operon protein 1 [Streptococcus pyogenes MGAS10394] YP_002995867.1 similar to competence protein ABC transporter subunit [Streptococcus pyogenes MGAS8232] YP_002995868.1 similar to competence protein [Streptococcus pyogenes MGAS8232] YP_002995869.1 similar to competence protein [Streptococcus pyogenes MGAS315] YP_002995870.1 similar to hypothetical protein SpyM3 0082 [Streptococcus pyogenes MGAS315] YP_002995871.1 similar to comG operon protein 6 [Streptococcus pyogenes MGAS5005] YP_002995872.1 similar to comG operon protein 6 [Streptococcus pyogenes MGAS10750] YP_002995873.1 similar to adenine-specific methyltransferase [Streptococcus pyogenes MGAS2096] YP_002995874.1 AckA utilizes acetate and can acetylate CheY which increases signal strength during flagellar rotation; utilizes magnesium and ATP; also involved in conversion of acetate to aceyl-CoA YP_002995875.1 similar to HTH-type transcriptional regulator [Streptococcus equi subsp. zooepidemicus MGCS10565] YP_002995876.1 similar to membrane-bound protease CAAX family [Streptococcus equi subsp. zooepidemicus MGCS10565] YP_002995877.1 similar to hypothetical protein Sez 1851 [Streptococcus equi subsp. zooepidemicus MGCS10565] YP_002995878.1 catalyzes the formation of L-proline from pyrroline-5-carboxylate YP_002995879.1 similar to glutamyl aminopeptidase [Streptococcus pyogenes MGAS10750] YP_002995880.1 similar to hypothetical protein MGAS10750 Spy0105 [Streptococcus pyogenes MGAS10750] YP_002995881.1 similar to hypothetical membrane associated protein [Streptococcus pyogenes MGAS5005] YP_002995882.1 similar to thioredoxin [Streptococcus pyogenes MGAS8232] YP_002995883.1 similar to tRNA binding domain protein [Streptococcus pyogenes MGAS10394] YP_002995884.1 binds to single stranded DNA and may facilitate the binding and interaction of other proteins to DNA YP_002995885.1 similar to deoxyadenosine kinase [Streptococcus pyogenes MGAS10394] YP_002995886.1 similar to tRNA-dihydrouridine synthase [Streptococcus pyogenes MGAS2096] YP_002995887.1 becomes active under oxidative stress; four conserved cysteines bind a zinc atom when they are in the reduced state and the enzyme is inactive; oxidative stress results in oxidized cysteines, release of zinc, and binding of Hsp33 to aggregation-prone proteins; forms dimers and higher order oligomers YP_002995888.1 similar to transcriptional regulator RofA [Streptococcus pyogenes MGAS10750] YP_002995889.1 similar to fimbrial subunit protein FszF [Streptococcus equi subsp. zooepidemicus MGCS10565] YP_002995890.1 similar to T-antigen-like fimbrial structural subunit protein FszE [Streptococcus equi subsp. zooepidemicus MGCS10565] YP_002995891.1 similar to sortase [Streptococcus pyogenes MGAS10270] YP_002995892.1 similar to sortase [Streptococcus pyogenes MGAS10270] YP_002995893.1 similar to fibronectin-binding protein [Streptococcus pyogenes MGAS10270] YP_002995894.1 similar to DNA-binding protein [Streptococcus pyogenes MGAS10394] YP_002995895.1 similar to translation initiation inhibitor [Streptococcus pyogenes MGAS10394] YP_002995896.1 similar to hypothetical protein SpyM50119 [Streptococcus pyogenes str. Manfredo] YP_002995897.1 similar to tellurite resistance protein [Streptococcus pyogenes MGAS10394] YP_002995898.1 similar to hypothetical membrane associated protein [Streptococcus pyogenes MGAS10394] YP_002995899.1 catalyzes the formation of N6-(1,2,-dicarboxyethyl)-AMP from L-aspartate, inosine monophosphate and GTP in AMP biosynthesis YP_002995900.1 similar to nucleoside-binding protein [Streptococcus pyogenes MGAS5005] YP_002995901.1 similar to pyruvate formate-lyase activating enzyme [Streptococcus pyogenes MGAS10394] YP_002995902.1 similar to DeoR family transcriptional regulator [Streptococcus pyogenes MGAS10394] YP_002995903.1 similar to sorbitol operon regulator [Streptococcus pyogenes MGAS10394] YP_002995904.1 similar to PTS system, cellobiose-specific IIA component [Streptococcus pyogenes MGAS5005] YP_002995905.1 similar to PTS system, cellobiose-specific IIB component [Streptococcus pyogenes MGAS10750] YP_002995906.1 similar to PTS system, cellobiose-specific IIB component [Streptococcus pyogenes MGAS10750] YP_002995907.1 similar to formate acetyltransferase [Streptococcus pyogenes MGAS10394] YP_002995908.1 similar to transaldolase from Escherichia coli; many organisms have multiple copies YP_002995909.1 forms dimers and octamers; involved in conversion of glycerol to dihydroxy-acetone YP_002995910.1 similar to hypothetical protein SsuiDRAFT 0887 [Streptococcus suis 89/1591] YP_002995911.1 similar to low temperature requirement C protein [Streptococcus pyogenes MGAS8232] YP_002995912.1 no hit YP_002995913.1 similar to MccC family protein [Streptococcus pneumoniae D39] YP_002995914.1 similar to hypothetical protein PsycPRwf 0104 [Psychrobacter sp. PRwf-1] YP_002995915.1 similar to YbaK / prolyl-tRNA synthetases associated domain YP_002995916.1 similar to predicted transcriptional regulator [Streptococcus suis 98HAH33] YP_002995917.1 similar to hypothetical protein SAG0685 [Streptococcus agalactiae 2603V/R] YP_002995918.1 similar to ATPase components of ABC transporters with duplicated ATPase domains, multidrug transport system [Streptococcus sanguinis SK36] YP_002995919.1 similar to cyclic nucleotide-binding domain protein [Lactococcus lactis subsp. cremoris MG1363] YP_002995920.1 similar to hypothetical protein llmg 1236 [Lactococcus lactis subsp. cremoris MG1363] YP_002995921.1 similar to nucleotide-binding protein implicated in inhibition of septum formation [Streptococcus suis 98HAH33] YP_002995922.1 no hit YP_002995923.1 similar to phosphoglycerate mutase family protein [Streptococcus equi subsp. zooepidemicus MGCS10565] YP_002995924.1 similar to topology modulation protein [Streptococcus pyogenes MGAS6180] YP_002995925.1 similar to acetyltransferase [Streptococcus pyogenes MGAS10394] YP_002995926.1 similar to transposase [Streptococcus pyogenes MGAS10270] YP_002995927.1 similar to transcriptional regulator [Streptococcus equi subsp. zooepidemicus MGCS10565] YP_002995928.1 similar to bacteriocin ABC-type exporter ATP binding/permease protein [Streptococcus sanguinis SK36] YP_002995929.1 similar to hypothetical protein M28 Spy1333 [Streptococcus pyogenes MGAS6180] YP_002995930.1 similar to streptomycin resistance protein [Streptococcus agalactiae 2603V/R] YP_002995931.1 similar to phosphoglycerate mutase family protein [Streptococcus equi subsp. zooepidemicus MGCS10565] YP_002995932.1 similar to transposase [Streptococcus pyogenes MGAS2096] YP_002995933.1 similar to transposase [Streptococcus pyogenes MGAS2096] YP_002995934.1 similar to hypothetical protein gbs1981 [Streptococcus agalactiae NEM316] YP_002995935.1 similar to hypothetical protein M28 Spy1332 [Streptococcus pyogenes MGAS6180] YP_002995936.1 similar to hypothetical protein M28 Spy1308 [Streptococcus pyogenes MGAS6180] YP_002995937.1 similar to ISSdy1 transposase OrfB [Streptococcus agalactiae 2603V/R] YP_002995938.1 similar to ISSdy1 transposase OrfA [Streptococcus agalactiae 515] YP_002995939.1 similar to protein kinase, [Streptococcus pneumoniae TIGR4] YP_002995940.1 similar to hypothetical protein SP 1060 [Streptococcus pneumoniae TIGR4] YP_002995941.1 similar to hypothetical protein SP 1059 [Streptococcus pneumoniae TIGR4] YP_002995942.1 similar to ABC transporter ATP-binding protein [Streptococcus pneumoniae TIGR4] YP_002995943.1 similar to ABC-2 transporter permease protein [Streptococcus pneumoniae TIGR4] YP_002995944.1 similar to transposase IS204/IS1001/IS1096/IS1165 [Streptococcus suis 89/1591] YP_002995946.1 similar to recombination factor protein RarA [Streptococcus thermophilus LMG 18311] YP_002995947.1 TrpG; with TrpE catalyzes the formation of anthranilate and glutamate from chorismate and glutamine; TrpG provides the glutamine amidotransferase activity YP_002995948.1 similar to para-aminobenzoate synthetase component I/4-amino-4-deoxychorismate lyase [Streptococcus pyogenes MGAS5005] YP_002995949.1 similar to hypothetical protein MGAS2096 Spy1717 [Streptococcus pyogenes MGAS2096] YP_002995950.1 methylates ribosomal protein L11 at multiple amino acid positions; mutations of these genes in Escherichia coli or Thermus thermophilus has no apparent phenotype YP_002995951.1 in Escherichia coli RsmE methylates the N3 position of the U1498 base in 16S rRNA; cells lacking this function can grow, but are outcompeted by wild-type; SAM-dependent m(3)U1498 methyltransferase YP_002995952.1 similar to HTH-type transcriptional regulator MalR-like [Streptococcus equi subsp. zooepidemicus MGCS10565] YP_002995953.1 similar to PTS system glucose-specific IIABC component [Streptococcus pyogenes MGAS10394] YP_002995954.1 similar to RgfB protein [Streptococcus pyogenes MGAS315] YP_002995955.1 similar to hypothetical protein SAG1944 [Streptococcus agalactiae 2603V/R] YP_002995956.1 similar to glucanase; deblocking aminopeptidase [Bacillus cereus E33L] YP_002995957.1 similar to hypothetical protein gbs0573 [Streptococcus agalactiae NEM316] YP_002995958.1 similar to inosine-uridine preferring nucleoside hydrolase [Streptococcus agalactiae 2603V/R] YP_002995959.1 has a stimulatory effect on the ribonucleotide reductase activity of NrdH with NrdEF YP_002995960.1 similar to trans-acting positive regulator [Streptococcus pyogenes MGAS10394] YP_002995961.1 similar to M protein YP_002995962.1 similar to GTP pyrophosphokinase [Streptococcus pyogenes MGAS10394] YP_002995963.1 hydrolyzes D-tyrosyl-tRNA(Tyr) into D-tyrosine and free tRNA(Tyr); possible defense mechanism against a harmful effect of D-tyrosine YP_002995964.1 similar to streptokinase [Streptococcus pyogenes MGAS10394] YP_002995965.1 similar to leucine rich protein [Streptococcus pyogenes MGAS10394] YP_002995966.1 similar to multiple sugar transport ATP-binding protein [Streptococcus pyogenes MGAS10394] YP_002995967.1 similar to glucan 1,6-alpha-glucosidase [Streptococcus pyogenes MGAS10394] YP_002995968.1 similar to pullulanase [Streptococcus pyogenes MGAS10394] YP_002995969.1 similar to hypothetical protein SPCG 1675 [Streptococcus pneumoniae CGSP14] YP_002995970.1 similar to thioredoxin [Streptococcus pyogenes MGAS2096] YP_002995971.1 member of preprotein translocase; forms a heterotrimer with SecD and SecF; links the SecD/SecF/YajC/YidC complex with the SecY/SecE/SecG complex YP_002995972.1 catalyzes the formation of undecaprenyl pyrophosphate from isopentenyl pyrophosphate YP_002995973.1 similar to phosphatidate cytidylyltransferase [Streptococcus pyogenes MGAS10394] YP_002995974.1 similar to pheromone-processing membrane metalloprotease [Streptococcus pyogenes MGAS10394] YP_002995975.1 similar to pheromone-processing membrane metalloprotease [Streptococcus pyogenes MGAS10394] YP_002995976.1 catalyzes the formation of prolyl-tRNA(Pro) from proline and tRNA(Pro) YP_002995977.1 similar to hypothetical protein ProS [Streptococcus equi subsp. zooepidemicus MGCS10565] YP_002995978.1 catalyzes DNA-template-directed extension of the 3'- end of a DNA strand by one nucleotide at a time; required for leading strand synthesis; PolC exhibits 3' to 5' exonuclease activity YP_002995979.1 similar to MarR family transcriptional regulator [Streptococcus pyogenes M1 GAS] YP_002995980.1 similar to NADPH-dependent FMN reductase [Streptococcus sanguinis SK36] YP_002995981.1 cleaves off formyl group from N-terminal methionine residues of newly synthesized proteins; binds iron(2+) YP_002995982.1 similar to Crp-like transcriptional regulator [Streptococcus thermophilus LMD-9] YP_002995983.1 similar to hypothetical protein SMU.145 [Streptococcus mutans UA159] YP_002995984.1 primary rRNA binding protein; helps nucleate assembly of 30S; binds directly to the 16S rRNA and an intersubunit bridge to the 23S rRNA; autoregulates translation through interactions with the mRNA leader sequence YP_002995985.1 similar to hypothetical protein M6 Spy1673 [Streptococcus pyogenes MGAS10394] YP_002995986.1 similar to PTS system mannitol (Cryptic)-specific IIA component [Streptococcus pyogenes MGAS10394] YP_002995987.1 similar to PTS system IIB component [Streptococcus pyogenes MGAS6180] YP_002995988.1 membrane component; functions with enzymes IIB (sgaB; ulaB) and IIA (sgaA; ulaC) enzyme I and HPr for anaerobic utilization and uptake of L-ascorbate; sgaTBA are regulated by yifQ as well as Crp and Fnr YP_002995989.1 similar to novel fructose-6-phosphate aldolase from Escherichia coli; enzyme from Methanocaldococcus janaschii shows transaldolase activity YP_002995990.1 similar to Polyribonucleotide nucleotidyltransferase [Streptococcus pyogenes MGAS10394] YP_002995991.1 similar to hypothetical protein M6 Spy1667 [Streptococcus pyogenes MGAS10394] YP_002995992.1 similar to serine acetyltransferase [Streptococcus pyogenes MGAS10394] YP_002995993.1 similar to hypothetical protein M5005 Spy 1656 [Streptococcus pyogenes MGAS5005] YP_002995994.1 catalyzes a two-step reaction; charges a cysteine by linking its carboxyl group to the alpha-phosphate of ATP then transfers the aminoacyl-adenylate to its tRNA YP_002995995.1 similar to hypothetical protein SpyM51627 [Streptococcus pyogenes str. Manfredo] YP_002995996.1 similar to conserved hypothetical protein [Enterococcus faecium DO] YP_002995997.1 similar to hypothetical protein EF3281 [Enterococcus faecalis V583] YP_002995998.1 similar to hypothetical membrane associated protein [Streptococcus pyogenes MGAS2096] YP_002995999.1 similar to 23S rRNA Gm2251 methyltransferase [Streptococcus pyogenes MGAS10394] YP_002996000.1 similar to hypothetical protein SpyM51624 [Streptococcus pyogenes str. Manfredo] YP_002996001.1 similar to DegV family protein [Streptococcus pyogenes MGAS10394] YP_002996002.1 similar to hypothetical membrane spanning protein [Streptococcus pyogenes MGAS10394] YP_002996003.1 similar to Cro/CI family transcriptional regulator [Streptococcus pyogenes MGAS6180] YP_002996004.1 similar to transposase [Streptococcus pyogenes MGAS10394] YP_002996005.1 similar to transposase [Streptococcus pyogenes MGAS5005] YP_002996006.1 similar to transposase [Streptococcus pyogenes MGAS10750] YP_002996007.1 similar to transposase [Streptococcus pyogenes MGAS10270] YP_002996008.1 in Escherichia coli this protein is one of the earliest assembly proteins in the large subunit YP_002996009.1 forms a direct contact with the tRNA during translation YP_002996010.1 similar to phage integrase family site specific recombinase [Streptococcus agalactiae A909] YP_002996011.1 similar to transcriptional regulator Cro/CI family [Streptococcus agalactiae CJB111] YP_002996012.1 similar to hypothetical protein SAG0219 [Streptococcus agalactiae 2603V/R] YP_002996013.1 similar to hypothetical protein SAG0220 [Streptococcus agalactiae 2603V/R] YP_002996014.1 similar to hypothetical protein SAG0221 [Streptococcus agalactiae 2603V/R] YP_002996015.1 similar to hypothetical protein SAG0222 [Streptococcus agalactiae 2603V/R] YP_002996016.1 similar to conserved hypothetical protein [Streptococcus agalactiae CJB111] YP_002996017.1 similar to hypothetical protein SAG0225 [Streptococcus agalactiae 2603V/R] YP_002996018.1 similar to recombination protein [Streptococcus agalactiae 2603V/R] YP_002996019.1 similar to hypothetical protein SAG0227 [Streptococcus agalactiae 2603V/R] YP_002996020.1 similar to hypothetical protein SAG0228 [Streptococcus agalactiae 2603V/R] YP_002996021.1 similar to hypothetical protein SAG0229 [Streptococcus agalactiae 2603V/R] YP_002996022.1 similar to phage integrase family integrase/recombinase [Streptococcus thermophilus LMG 18311] YP_002996023.1 similar to transposase [Streptococcus pyogenes MGAS9429] YP_002996024.1 similar to transposase [Streptococcus pyogenes MGAS2096] YP_002996025.1 similar to lantibiotic biosynthesis protein [Streptococcus thermophilus LMG 18311] YP_002996026.1 similar to lantibiotic efflux protein [Streptococcus thermophilus CNRZ1066] YP_002996027.1 similar to ATP-dependent DNA helicase recG [Streptococcus agalactiae 515] YP_002996028.1 similar to predicted transcriptional regulator containing HTH domain [Streptococcus thermophilus LMD-9] YP_002996029.1 similar to 5-methylcytosine methyltransferase [Lactococcus lactis subsp. lactis bv. diacetylactis] YP_002996030.1 similar to restriction enzyme [Lactococcus lactis subsp. lactis bv. diacetylactis] YP_002996031.1 no hit YP_002996032.1 no hit YP_002996033.1 similar to hypothetical protein CLOSS21 00385 [Clostridium sp. SS2/1] YP_002996034.1 similar to PTS system galactitol-specific IIA component [Streptococcus agalactiae A909] YP_002996035.1 similar to PTS system galactitol-specific IIC component [Streptococcus agalactiae A909] YP_002996036.1 similar to PTS system galactitol-specific IIB component [Streptococcus agalactiae A909] YP_002996037.1 similar to hypothetical protein ANACAC 03037 [anaerostipes caccae DSM 14662] YP_002996038.1 similar to hypothetical protein ANACAC 03039 [anaerostipes caccae DSM 14662] YP_002996039.1 similar to hypothetical protein ANACAC 03038 [anaerostipes caccae DSM 14662] YP_002996040.1 similar to hypothetical protein CLOL250 01537 [Clostridium sp. L2-50] YP_002996041.1 similar to competence protein ComX1 [Streptococcus pyogenes MGAS315] YP_002996042.1 catalyzes the formation of 4-phospho-L-aspartate from L-aspartate and ATP; lysine and threonine sensitive YP_002996043.1 mediates pseudouridylation (positions 38, 39, 40) at the tRNA anticodon region which contributes to the structural stability YP_002996044.1 catalyzes the formation of 4-amino-2-methyl-5-diphosphomethylpyrimidine YP_002996045.1 similar to hypothetical membrane spanning protein [Streptococcus pyogenes MGAS5005] YP_002996046.1 similar to hypothetical protein M28 Spy1603 [Streptococcus pyogenes MGAS6180] YP_002996047.1 similar to conserved hypothetical protein possible mechanosensitive ion channel [Streptococcuspyogenes NZ131] YP_002996048.1 similar to alpha-amylase precursor AmyE [Streptococcus equi subsp. zooepidemicus MGCS10565] YP_002996049.1 similar to alpha-amylase precursor AmyE [Streptococcus equi subsp. zooepidemicus MGCS10565] YP_002996050.1 Tig; RopA; peptidyl-prolyl cis/trans isomerase; promotes folding of newly synthesized proteins; binds ribosomal 50S subunit; forms a homodimer YP_002996051.1 participates in both the initiation and recycling phases of transcription; in the presence of the delta subunit, RNAP displays an increased specificity of transcription, a decreased affinity for nucleic acids, and an increased efficiency of RNA synthesis because of enhanced recycling YP_002996052.1 CTP synthase; cytidine triphosphate synthetase; catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen; in Escherichia coli this enzyme forms a homotetramer YP_002996053.1 similar to autolysin sensor kinase protein [Staphylococcus aureus subsp. aureus MRSA252] YP_002996054.1 similar to two-component response regulator LytR [Carnobacterium sp. AT7] YP_002996055.1 similar to murein hydrolase regulator LrgA [Staphylococcus aureus subsp. aureus JH9] YP_002996056.1 in conjunction with LrgA this protein inhibits the expression or activity of extracellular murein hydrolases YP_002996057.1 similar to alpha /beta hydrolase [Streptococcus pyogenes MGAS10394] YP_002996058.1 catalyzes the formation of glycerone phosphate and glyceraldehyde 3-phosphate from fructose 1,6, bisphosphate YP_002996059.1 similar to transposase [Streptococcus pyogenes MGAS315] YP_002996060.1 similar to transposase [Streptococcus pyogenes MGAS10270] YP_002996061.1 required for 70S ribosome assembly YP_002996062.1 similar to alkaline-shock protein [Streptococcus pyogenes M1 GAS] YP_002996063.1 similar to hypothetical protein spyM18 1950 [Streptococcus pyogenes MGAS8232] YP_002996064.1 similar to membrane protease protein family [Streptococcus pyogenes MGAS10394] YP_002996065.1 similar to amino acid transport ATP-binding protein [Streptococcus pyogenes MGAS10394] YP_002996066.1 similar to ABC transporter amino acid-binding protein [Streptococcus pyogenes MGAS10394] YP_002996067.1 similar to hypothetical membrane spanning protein [Streptococcus pyogenes MGAS2096] YP_002996068.1 BacA; phosphatase activity in Escherichia coli not kinase; involved in bacitracin resistance as bacitracin supposedly sequesters undecaprenyl disphosphate which reduces the pool of lipid carrier available to the cell YP_002996069.1 enables recognition and targeting of proteins for proteolysis, involved in negative regulation of competence YP_002996070.1 similar to undecaprenyl-phosphate alpha-N-acetylglucosaminephosphotransferase [Streptococcus pyogenes MGAS10750] YP_002996071.1 similar to ATP-dependent transporter sufC [Streptococcus pyogenes MGAS2096] YP_002996072.1 similar to SufD protein [Streptococcus pyogenes MGAS10270] YP_002996073.1 similar to aminotransferase [Streptococcus pyogenes MGAS315] YP_002996074.1 similar to IscU [Streptococcus pyogenes MGAS10394] YP_002996075.1 similar to hypothetical protein spyM18 0278 [Streptococcus pyogenes MGAS8232] YP_002996076.1 similar to D-alanyl-D-alanine carboxypeptidase [Streptococcus pyogenes MGAS10270] YP_002996077.1 similar to D-alanyl-D-alanine carboxypeptidase [Streptococcus pyogenes MGAS315] YP_002996078.1 similar to oligopeptide-binding protein [Streptococcus pyogenes MGAS6180] YP_002996079.1 similar to oligopeptide transport system permease protein oppB [Streptococcus pyogenes MGAS10750] YP_002996080.1 similar to oligopeptide permease [Streptococcus pyogenes MGAS8232] YP_002996081.1 similar to oligopeptide transport ATP-binding protein [Streptococcus pyogenes MGAS6180] YP_002996082.1 similar to oligopeptide ABC transporter, ATP-binding protein [Streptococcus pyogenes MGAS315] YP_002996083.1 similar to lipase [Streptococcus pyogenes MGAS10394] YP_002996084.1 in Bacillus subtilis this enzyme appears to be involved in 30S ribosomal RNA subunit biogenesis YP_002996085.1 similar to hypothetical RNA binding protein [Streptococcus pyogenes MGAS10394] YP_002996086.1 transfers an adenyl group from ATP to NaMN to form nicotinic acid adenine dinucleotide (NaAD) which is then converted to the ubiquitous compound NAD by NAD synthetase; essential enzyme in bacteria YP_002996087.1 similar to hydrolase (HAD superfamily) [Streptococcus pyogenes MGAS10394] YP_002996088.1 similar to isochorismatase [Streptococcus pyogenes MGAS10750] YP_002996089.1 similar to iojap protein family [Streptococcus pyogenes MGAS10394] YP_002996090.1 similar to methyltransferase [Streptococcus pyogenes MGAS10394] YP_002996091.1 similar to hypothetical protein stu1615 [Streptococcus thermophilus LMG 18311] YP_002996092.1 similar to transcriptional regulator MerR family [Streptococcus equi subsp. zooepidemicus MGCS10565] YP_002996093.1 similar to internalin A-like histidine triad lipoprotein [Streptococcus equi subsp. zooepidemicus MGCS10565] YP_002996094.1 no hit YP_002996095.1 similar to biotin synthetase [Streptococcus agalactiae 2603V/R] YP_002996096.1 similar to hypothetical protein M6 Spy0297 [Streptococcus pyogenes MGAS10394] YP_002996097.1 similar to ABC transporter substrate-binding protein [Streptococcus pyogenes MGAS10394] YP_002996098.1 similar to ABC transporter substrate-binding protein [Streptococcus pyogenes MGAS10394] YP_002996099.1 similar to ABC transporter substrate-binding protein [Streptococcus pyogenes MGAS10394] YP_002996100.1 similar to acetylornithine deacetylase /succinyl-diaminopimelate desuccinylase (M20/M25/M40 family peptidase), [Streptococcus sanguinis SK36] YP_002996101.1 similar to ABC transporter ATP-binding protein [Streptococcus pyogenes MGAS10394] YP_002996102.1 similar to ABC transporter permease protein [Streptococcus pyogenes MGAS10394] YP_002996103.1 similar to Branched-chain amino acid transport system carrier protein [Streptococcus pyogenes MGAS10394] YP_002996104.1 involved in the import of serine and threonine coupled with the import of sodium YP_002996105.1 similar to KtrA [Streptococcus pyogenes MGAS10394] YP_002996106.1 similar to KtrB [Streptococcus pyogenes MGAS10394] YP_002996107.1 glucose-inhibited division protein B; SAM-dependent methyltransferase; methylates the N7 position of guanosine in position 527 of 16S rRNA YP_002996108.1 similar to LemA [Streptococcus pyogenes MGAS10394] YP_002996109.1 metalloprotease YP_002996110.1 similar to hypothetical cytosolic protein [Streptococcus pyogenes MGAS10394] YP_002996111.1 similar to response regulator CsrR [Streptococcus pyogenes MGAS10394] YP_002996112.1 similar to transmembrane histidine kinase CsrS [Streptococcus pyogenes MGAS10394] YP_002996113.1 similar to ribonucleotide reductase NrdR family transcriptional regulator [Streptococcus equi subsp. zooepidemicus MGCS10565] YP_002996114.1 replication initiation/membrane attachment protein[DNA replication recombination and repair]; COG3611; similar to replicative DNA helicase [Streptococcus pyogenes MGAS6180] YP_002996115.1 Primosomal protein that may act to load helicase DnaC during DNA replication YP_002996116.1 EngA; essential Neisserial GTPase; synchronizes cellular events by interacting with multiple targets with tandem G-domains; overexpression in Escherichia coli suppresses rrmJ mutation; structural analysis of the Thermotoga maritima ortholog shows different nucleotide binding affinities in the two binding domains YP_002996117.1 similar to SWF/SNF family helicase [Streptococcus pyogenes MGAS10394] YP_002996118.1 similar to hypothetical protein spyM18 0396 [Streptococcus pyogenes MGAS8232] YP_002996119.1 Catalyzes the formation of UDP-N-acetylmuramoyl-L-alanine from UDP-N-acetylmuramate and L-alanine in peptidoglycan synthesis YP_002996120.1 similar to arylalkylamine n-acetyltransferase [Streptococcus pyogenes MGAS8232] YP_002996121.1 similar to aminodeoxychorismate lyase family [Streptococcus pyogenes MGAS10394] YP_002996122.1 necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites; arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus YP_002996123.1 involved in biogenesis of membrane proteins; Firmicutes specific proteins are shorter than other bacterial counterparts and have a signal peptide and lipid attachment site YP_002996124.1 catalyzes the hydrolysis of acylphosphate YP_002996125.1 similar to 23S rRNA methyltransferase [Streptococcus pyogenes MGAS10394] YP_002996126.1 similar to hydrolase (HAD superfamily) [Streptococcus pyogenes MGAS10394] YP_002996127.1 similar to integral membrane protein [Streptococcus pyogenes MGAS10394] YP_002996128.1 similar to hypothetical protein M6 Spy0328 [Streptococcus pyogenes MGAS10394] YP_002996129.1 converts L-glutamate to D-glutamate, a component of peptidoglycan YP_002996130.1 HAM1-like protein; Rec-dependent growth; RgdB; yggV; it is suspected that this protein functions to remove misincorporated bases such as xanthine or hypoxanthine YP_002996131.1 similar to hypothetical protein spyM18 0413 [Streptococcus pyogenes MGAS8232] YP_002996132.1 similar to hypothetical protein [Streptococcus pyogenes MGAS5005] YP_002996133.1 site-specific tyrosine recombinase which cuts and rejoins DNA molecules; binds cooperatively to specific DNA consensus sites; forms a heterotetrameric complex with XerC; XerCD exhibit similar sequences; essential to convert chromosome dimers to monomers during cell division and functions during plasmid segregation; cell division protein FtsK may regulate the XerCD complex; enzyme from Streptococcus group has unusual active site motifs YP_002996134.1 functions during chromosome segregation; may form a condensin-like structure with SMC and ScpB YP_002996135.1 functions during chromosome segregation; may form a condensin-like structure with SMC and ScpA; forms a homodimer YP_002996136.1 similar to Ribosomal large subunit pseudouridine synthase B [Streptococcus pyogenes MGAS10394] YP_002996137.1 similar to hypothetical protein Sez 1639 [Streptococcus equi subsp. zooepidemicus MGCS10565] YP_002996138.1 similar to 23S rRNA methyltransferase [Streptococcus pyogenes MGAS10394] YP_002996139.1 similar to hypothetical protein spyM18 0427 [Streptococcus pyogenes MGAS8232] YP_002996140.1 similar to phosphatidylglycerophosphatase B homolog [Streptococcus pyogenes MGAS5005] YP_002996141.1 similar to Fe-S oxidoreductase [Streptococcus pyogenes MGAS10394] YP_002996142.1 similar to SAM-dependent methyltransferase [Streptococcus pyogenes M1 GAS] YP_002996143.1 similar to hemolysin [Streptococcus pyogenes MGAS8232] YP_002996144.1 similar to pyruvate formate-lyase activating enzyme [Streptococcus pyogenes MGAS10394] YP_002996145.1 catalyzes the hydrolysis of pyrophosphate to phosphate YP_002996146.1 similar to hypothetical cytosolic protein [Streptococcus pyogenes MGAS10394] YP_002996147.1 similar to ferrichrome transport system permease protein [Streptococcus pyogenes MGAS5005] YP_002996148.1 similar to ferrichrome transport system permease protein [Streptococcus pyogenes MGAS5005] YP_002996149.1 similar to ferrichrome-binding protein [Streptococcus pyogenes MGAS5005] YP_002996150.1 similar to ferrichrome transport ATP-binding protein [Streptococcus pyogenes MGAS5005] YP_002996151.1 involved in cell wall formation; peptidoglycan synthesis; cytoplasmic enzyme; catalyzes the addition of lysine to UDP-N-acetylmuramoyl-L-alanyl-D-glutamate forming UDP-N-acetylmuramoyl-L-alanyl-D-glutamyl-L-lysine YP_002996152.1 similar to export protein for polysaccharides and teichoic acids [Streptococcus pyogenes MGAS5005] YP_002996153.1 similar to transposase [Streptococcus pyogenes MGAS10394] YP_002996154.1 Catalyzes the formation of uracil and 5-phospho-alpha-D-ribosy 1-diphosphate from UMP and diphosphate YP_002996155.1 hydrolyzes proteins to small peptides; with the ATPase subunits ClpA or ClpX, ClpP degrades specific substrates YP_002996156.1 similar to hypothetical protein gbs2095 [Streptococcus agalactiae NEM316] YP_002996157.1 similar to hypothetical proteinSMU.1671c [Streptococcus mutans UA159] YP_002996158.1 similar to conserved hypothetical protein [Streptococcus pyogenes M1GAS] YP_002996159.1 similar to ABC transporter, branched chain amino acid-binding protein [Streptococcus mutans UA159] YP_002996160.1 similar to branched chain amino acid ABC transporter, permease protein [Streptococcus mutans UA159] YP_002996161.1 similar to branched chain amino acid ABC transporter, permease protein [Streptococcus mutans UA159] YP_002996162.1 similar to branched-chain amino acid ABC transporter ATP binding protein [Streptococcus thermophilus CNRZ1066] YP_002996163.1 similar to ABC-type branched-chain amino acid transport system ATPase component [Streptococcus suis 98HAH33] YP_002996164.1 similar to hypothetical protein STRINF 01997 [Streptococcus infantarius subsp. infantarius ATCC BAA-102] YP_002996165.1 catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to thymidine monophosphate (dTMP) to form thymidine diphosphate (dTDP) YP_002996166.1 catalyzes the DNA-template-directed extension of the 3'-end of a DNA strand; the delta' subunit seems to interact with the gamma subunit to transfer the beta subunit on the DNA. YP_002996167.1 similar to DNA replicationintiation control protein YabA [Streptococcus pyogenes M1GAS]; Involved in initiation control of chromosomereplication. YP_002996168.1 in Bacillus subtilis this protein is involved in the negative regulation of DNA replication initiation; interacts with DnaN and DnaA YP_002996169.1 similar to corrin /porphyrin methyltransferase [Streptococcus pyogenes MGAS6180] YP_002996170.1 similar to hypothetical membrane associated protein [Streptococcus pyogenes MGAS5005] YP_002996171.1 similar to copper homeostasis protein [Streptococcus pyogenes MGAS6180] YP_002996172.1 catalyzes the formation of 3-phosphonooxypyruvate and glutamate from O-phospho-L-serine and 2-oxoglutarate; required both in major phosphorylated pathway of serine biosynthesis and in the biosynthesis of pyridoxine YP_002996173.1 similar to acetyltransferase [Streptococcus equi] YP_002996174.1 similar to methylated-DNA-protein-cysteine S-methyltransferase[Streptococcus mutans UA159] YP_002996175.1 similar to arsenate reductase family protein [Streptococcus pyogenes MGAS10270] YP_002996176.1 similar to hypothetical protein SAG1540 [Streptococcus agalactiae 2603V/R] YP_002996177.1 similar to glyoxalase family protein [Streptococcus agalactiae 2603V/R] YP_002996178.1 similar to sugar-binding transcriptional regulator YP_002996179.1 similar to HAD superfamily hydrolase [Streptococcus agalactiae 2603V/R] YP_002996180.1 similar to 3'-exo-deoxyribonuclease [Streptococcus pyogenes M1 GAS] YP_002996181.1 similar to hemolysis inducing protein [Streptococcus mutans UA159] YP_002996182.1 similar to L-lactate permease YP_002996183.1 similar to lactate oxidase [Streptococcus pyogenes MGAS8232] YP_002996184.1 similar to cell envelope proteinase A [Streptococcus pyogenes] YP_002996185.1 similar to cell envelope proteinase A [Streptococcus pyogenes] YP_002996186.1 similar to cell envelope proteinase A [Streptococcus pyogenes] YP_002996187.1 similar to conserved hypothetical protein [Streptococcus suis 89/1591] YP_002996188.1 similar to hypothetical membrane spanning protein [Streptococcus pyogenes MGAS2096] YP_002996189.1 methionine--tRNA ligase; MetRS; adds methionine to tRNA(Met) with cleavage of ATP to AMP and diphosphate; some MetRS enzymes form dimers depending on a C-terminal domain that is also found in other proteins such as Trbp111 in Aquifex aeolicus and the cold-shock protein CsaA from Bacillus subtilis while others do not; four subfamilies exist based on sequence motifs and zinc content YP_002996190.1 similar to ribonucleoside-diphosphate reductase beta chain [Streptococcus pyogenes MGAS2096] YP_002996191.1 in Salmonella NrdI has a stimulatory effect on the ribonucleotide reductase activity of NrdH with NrdEF YP_002996192.1 Catalyzes the rate-limiting step in dNTP synthesis YP_002996193.1 similar to branched-chain amino acid transport system II carrier protein [Streptococcus agalactiae 2603V/R] YP_002996194.1 similar to transposase [Streptococcus pyogenes MGAS2096] YP_002996195.1 similar to hypothetical protein spr0700 [Streptococcus pneumoniae R6] YP_002996196.1 Catalyzes the first of the two reduction steps in the elongation cycle of fatty acid synthesis YP_002996197.1 similar to conserved hypothetical protein [Streptococcus agalactiae H36B] YP_002996198.1 similar to hypothetical protein SPs1547 [Streptococcus pyogenes SSI-1] YP_002996199.1 similar to phosphoglycerate transporter protein [Streptococcus pyogenes MGAS6180] YP_002996200.1 forms a homotrimer; catalyzes the acetylation of glucosamine-1-phosphate and uridylation of N-acetylglucosamine-1-phosphate to produce UDP-GlcNAc; function in cell wall synthesis YP_002996201.1 similar to ADP-ribose pyrophosphatase [Streptococcus pyogenes MGAS10750] YP_002996202.1 enables the cleavage of the glycosidic bond in both 5'-methylthioadenosine and S-adenosylhomocysteine YP_002996203.1 similar to iron-dependent repressor [Streptococcus pyogenes MGAS6180] YP_002996204.1 similar to manganese-binding protein [Streptococcus pyogenes MGAS5005] YP_002996205.1 similar to manganese transport system ATP-binding protein [Streptococcus pyogenes MGAS5005] YP_002996206.1 similar to metal cation ABC transporter membrane protein [Streptococcus pyogenes str. Manfredo] YP_002996207.1 similar to peptidyl-prolyl cis-trans isomerase [Streptococcus pyogenes MGAS5005] YP_002996208.1 similar to cell division protein [Streptococcus pyogenes MGAS5005] YP_002996209.1 similar to integral membrane protein [Streptococcus pyogenes MGAS5005] YP_002996210.1 similar to transposase [Streptococcus pyogenes MGAS10270] YP_002996211.1 binds directly to 23S ribosomal RNA YP_002996212.1 in Escherichia coli and Methanococcus, this protein autoregulates expression; the binding site in the mRNA mimics the binding site in the 23S rRNA YP_002996213.1 Catalyzes the phosphorylation of UMP to UDP YP_002996214.1 Rrf; Frr; ribosome-recycling factor; release factor 4; RF4; recycles ribosomes upon translation termination along with release factor RF-3 and elongation factor EF-G; A GTPase-dependent process results in release of 50S from 70S; inhibited by release factor RF-1; essential for viability; structurally similar to tRNAs YP_002996215.1 similar to s1 RNA binding domain [Streptococcus pyogenes MGAS5005] YP_002996216.1 this stereospecific enzymes reduces the S isomer of methionine sulfoxide while MsrB reduces the R form; provides protection against oxidative stress YP_002996217.1 similar to D-alanyl-D-alanine carboxypeptidase [Streptococcus pyogenes MGAS5005] YP_002996218.1 similar to surface antigen [Streptococcus pyogenes MGAS5005] YP_002996219.1 in group A Streptococci this protein was found to cross react with anti myosin antibodies and may play a role in rheumatic fever YP_002996220.1 similar to PhoH protein [Streptococcus pyogenes MGAS5005] YP_002996221.1 similar to uracil DNA glycosylase superfamily protein [Streptococcus pyogenes MGAS5005] YP_002996222.1 similar to hypothetical protein M5005 Spy 0388 [Streptococcus pyogenes MGAS5005] YP_002996223.1 similar to diacylglycerol kinase [Streptococcus pyogenes MGAS5005] YP_002996224.1 Era; Escherichia coli Ras-like protein; Bex; Bacillus Era-complementing segment; essential protein in Escherichia coli that is involved in many cellular processes; GTPase; binds the cell membrane through apparent C-terminal domain; mutants are arrested during the cell cycle; Streptococcus pneumoniae Era binds to RNA and Escherichia coli Era binds 16S rRNA and 30S ribosome YP_002996225.1 similar to phosphohydrolase [Streptococcus pyogenes MGAS10750] YP_002996226.1 similar to bacteriocin processing peptidase / bacteriocin export ABC transporter [Streptococcus pyogenes MGAS10750] YP_002996227.1 similar to hypothetical protein MGAS10750 Spy0398 [Streptococcus pyogenes MGAS10750] YP_002996228.1 similar to hypothetical protein MGAS10750 Spy0399 [Streptococcus pyogenes MGAS10750] YP_002996229.1 similar to bacteriocin BlpM [Streptococcus pneumoniae SP6-BS73] YP_002996230.1 similar to bacteriocin Blp [Streptococcus pneumoniae G54] YP_002996231.1 similar to response regulator FasA [Streptococcus pyogenes MGAS10750] YP_002996232.1 similar to sensory transduction protein kinase [Streptococcus pyogenes MGAS10750] YP_002996233.1 similar to hypothetical protein MGAS10750 Spy0405 [Streptococcus pyogenes MGAS10750] YP_002996234.1 similar to SilD [Streptococcus pyogenes] YP_002996235.1 similar to bacteriocin processing peptidase / bacteriocin export ABC transporter [Streptococcus pyogenes MGAS10750] YP_002996236.1 similar to transposase [Streptococcus pyogenes MGAS10270] YP_002996237.1 similar to hypothetical membrane associated protein [Streptococcus pyogenes MGAS10270] YP_002996238.1 similar to hypothetical protein M6 Spy0424 [Streptococcus pyogenes MGAS10394] YP_002996239.1 similar to hypothetical protein SPs1514 [Streptococcus pyogenes SSI-1] YP_002996240.1 similar to hypothetical protein MGAS10750 Spy0413 [Streptococcus pyogenes MGAS10750] YP_002996241.1 similar to hypothetical protein M6 Spy0427 [Streptococcus pyogenes MGAS10394] YP_002996242.1 similar to CAAX amino terminal protease family protein [Streptococcus agalactiae NEM316] YP_002996243.1 similar to hypothetical protein MGAS2096 Spy0420 [Streptococcus pyogenes MGAS2096] YP_002996244.1 similar to hypothetical protein SAG1491 [Streptococcus agalactiae 2603V/R] YP_002996245.1 similar to transcriptional regulator [Streptococcus pyogenes MGAS10750] YP_002996246.1 Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases YP_002996247.1 catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A; involved in coenzyme A biosynthesis YP_002996248.1 similar to ABC transporter ATP binding protein [Streptococcus agalactiae 2603V/R] YP_002996249.1 similar to hypothetical protein SAG1486 [Streptococcus agalactiae 2603V/R] YP_002996250.1 similar to ATPase [Streptococcus pyogenes MGAS9429] YP_002996251.1 similar to multidrug resistance protein B [Streptococcus pyogenes MGAS10394] YP_002996252.1 in Escherichia coli BM108, a mutation that results in lack of L33 synthesis had no effect on ribosome synthesis or function; there are paralogous genes in several bacterial genomes, and a CXXC motif for zinc binding and an upstream regulation region of the paralog lacking this motif that are regulated by zinc similar to other ribosomal proteins like L31; the proteins in this group lack the CXXC motif YP_002996253.1 similar to translocase [Streptococcus pyogenes MGAS315] YP_002996254.1 similar to exoribonuclease II [Streptococcus pyogenes MGAS10750] YP_002996255.1 binds to ssrA RNA (tmRNA) and is required for its successful binding to ribosomes; also appears to function in the trans-translation step by promoting accommodation of tmRNA into the ribosomal A site; SmpB protects the tmRNA from RNase R degradation in Caulobacter crescentus; both the tmRNA and SmpB are regulated in cell cycle-dependent manner; functions in release of stalled ribosomes from damaged mRNAs and targeting proteins for degradation YP_002996256.1 similar to sugar transferase [Streptococcus pyogenes MGAS315] YP_002996257.1 similar to phage-encoded extracellular streptodornase D [Streptococcus pyogenes];deoxyribonuclease YP_002996258.1 similar to lactoylglutathione lyase [Streptococcus pyogenes MGAS315] YP_002996259.1 similar to NAD(P)H-flavin oxidoreductase [Streptococcus pyogenes MGAS315] YP_002996260.1 similar to Xaa-Pro dipeptidase [Streptococcus pyogenes MGAS10394] YP_002996261.1 similar to catabolite control protein A [Streptococcus pyogenes MGAS5005] YP_002996262.1 converts 1,4-alpha-D-glucans to maltodextrin YP_002996263.1 similar to glycosyltransferase [Streptococcus pyogenes MGAS5005] YP_002996264.1 similar to 1,2-diacylglycerol 3-glucosyltransferase [Streptococcus pyogenes MGAS10270] YP_002996265.1 catalyzes a two-step reaction, first charging a threonine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; catalyzes the formation of threonyl-tRNA(Thr) from threonine and tRNA(Thr) YP_002996266.1 similar to ABC transporter ATP-binding protein [Streptococcus pyogenesstr. Manfredo] YP_002996267.1 similar to daunorubicin resistance transmembrane protein [Streptococcus pyogenes MGAS5005] YP_002996268.1 similar to daunorubicin resistance transmembrane protein [Streptococcus pyogenes MGAS10750] YP_002996269.1 similar to ABC transporter permease protein [Streptococcus pyogenes MGAS10750] YP_002996270.1 similar to DhaK; in Lactococcus lactis this protein froms a stable complex with DhaS and activates transcription of the dha operon in the presence of dihydroxyacetone YP_002996271.1 similar to hypothetical protein SpyM51438 [Streptococcus pyogenes str.Manfredo] YP_002996272.1 with DhaL and DhaM forms dihydroxyacetone kinase, which is responsible for phosphorylating dihydroxyacetone; DhaK is the dihydroxyacetone binding subunit of the dihydroxyacetone kinase YP_002996273.1 similar to dihydroxyacetone kinase family protein [Streptococcus pyogenes str. Manfredo] YP_002996274.1 similar to dihydroxyacetone kinase phosphotransfer protein [Streptococcus pyogenes MGAS10394] YP_002996275.1 similar to glycerol uptake facilitator protein [Streptococcus pyogenes MGAS10394] YP_002996276.1 similar to hypothetical protein SpyM51433 [Streptococcus pyogenes str.Manfredo] YP_002996277.1 similar to acetyl-CoA acetyltransferase [Streptococcus pyogenes MGAS5005] YP_002996278.1 similar to long-chain-fatty-acid-CoA ligase [Streptococcus pyogenes MGAS5005] YP_002996279.1 similar to hypothetical cytosolic protein [Streptococcus pyogenes MGAS5005] YP_002996280.1 similar to aminoacid (glutamine) ABC transporter permease protein [Streptococcus thermophilus CNRZ1066] YP_002996281.1 similar to amino acid ABC transporter integral membrane protein [Streptococcus mutans UA159] YP_002996282.1 similar to hypothetical protein gbs0689 [Streptococcus agalactiae NEM316] YP_002996283.1 similar to amino acid ABC transporter, amino acid-binding protein [Streptococcus agalactiae 2603V/R] YP_002996284.1 similar to aminoacid (glutamine) ABC transporter ATP-binding protein [Streptococcus thermophilus CNRZ1066] YP_002996285.1 similar to two-component response regulator [Streptococcus pyogenes MGAS5005] YP_002996286.1 similar to two-component sensor histidine kinase [Streptococcus pyogenes MGAS5005] YP_002996287.1 similar to Zn-dependent hydrolase [Streptococcus pyogenes MGAS5005] YP_002996288.1 cytoplasmic enzyme involved in processing rRNA and some mRNAs; substrates typically have dsRNA regions; forms a homodimer; have N-terminal nuclease and C-terminal RNA-binding domains; requires magnesium as preferred ion for activity YP_002996289.1 similar to chromosome partition protein [Streptococcus pyogenes MGAS5005] YP_002996290.1 similar to CspA [Streptococcus agalactiae] YP_002996291.1 similar to reticulocyte binding protein [Streptococcus agalactiae 515] YP_002996292.1 similar to HAD superfamily hydrolase [Streptococcus pyogenes MGAS5005] YP_002996293.1 similar to HAD superfamily hydrolase [Streptococcus pyogenes MGAS5005] YP_002996294.1 similar to HAD superfamily hydrolase [Streptococcus pyogenes MGAS5005] YP_002996295.1 similar to cell division protein [Streptococcus pyogenes MGAS5005] YP_002996296.1 similar to multidrug resistance protein B [Streptococcus pyogenes MGAS5005] YP_002996297.1 similar to major facilitator superfamily protein [Streptococcus pyogenes str. Manfredo] YP_002996298.1 similar to transcription antiterminator YP_002996299.1 similar to PTS system beta-glucoside-specific IIABC component [Streptococcus pyogenes MGAS5005] YP_002996300.1 similar to 6-phospho-beta-glucosidase [Streptococcus pyogenes MGAS5005] YP_002996301.1 similar to hypothetical membrane spanning protein [Streptococcus pyogenesMGAS5005] YP_002996302.1 similar to hypothetical membrane spanning protein [Streptococcus pyogenesMGAS5005] YP_002996303.1 similar to hypothetical protein MGAS9429 Spy0471 [Streptococcus pyogenes MGAS9429] YP_002996304.1 similar to hypothetical protein spr1892 [Streptococcus pneumoniae R6] YP_002996305.1 similar to response regulator [Streptococcus pneumoniae R6] YP_002996306.1 similar to histidine kinase [Streptococcus pneumoniae R6] YP_002996307.1 similar to phosphate ABC transporter, phosphate-binding protein [Streptococcus pneumoniae SP9-BS68] YP_002996308.1 similar to phosphate ABC transporter permease protein [Streptococcus pneumoniae TIGR4] YP_002996309.1 similar to phosphate ABC transporter permease protein [Streptococcus pneumoniae TIGR4] YP_002996310.1 ATP-binding protein; PstABCS is an ATP dependent phosphate uptake system which is responsible for inorganic phosphate uptake during phosphate starvation YP_002996311.1 similar to negative regulator of pho regulon for phosphate transport [Streptococcus pneumoniae R6] YP_002996312.1 similar to hypothetical protein SPy 0580 [Streptococcus pyogenes M1 GAS] YP_002996313.1 similar to hypothetical protein M5005 Spy 0482 [Streptococcus pyogenes MGAS5005] YP_002996314.1 similar to hypothetical protein SpyM51378 [Streptococcus pyogenes str. Manfredo] YP_002996315.1 catalyzes the phosphorylation of the phosphocarrier protein HPr of the bacterial phosphotransferase system YP_002996316.1 transfers the N-acyl diglyceride moiety to the prospective N-terminal cysteine in prolipoprotein YP_002996317.1 similar to hypothetical protein M5005 Spy 0486 [Streptococcus pyogenes MGAS5005] YP_002996318.1 similar to hypothetical protein MGAS10750 Spy0508 [Streptococcus pyogenes MGAS10750] YP_002996319.1 similar to hypothetical protein SpyM51373 [Streptococcus pyogenes str.Manfredo] YP_002996320.1 similar to peptidase [Streptococcus pyogenes str. Manfredo] YP_002996321.1 similar to peptidase family U32 [Streptococcus pyogenes MGAS5005] YP_002996322.1 similar to hypothetical cytosolic protein [Streptococcus pyogenes MGAS10750] YP_002996323.1 similar to hypothetical protein M28 Spy0473 [Streptococcus pyogenes MGAS6180] YP_002996324.1 similar to hypothetical protein SAG1433 [Streptococcus agalactiae 2603V/R] YP_002996325.1 similar to ammonium transporter (Amt) family protein [Streptococcus agalactiae A909] YP_002996326.1 class II; LysRS2; catalyzes a two-step reaction, first charging a lysine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; in Methanosarcina barkeri, LysRS2 charges both tRNA molecules for lysine that exist in this organism and in addition can charge the tRNAPyl with lysine in the presence of LysRS1 YP_002996327.1 similar to HAD superfamily hydrolase [Streptococcus pyogenes MGAS5005] YP_002996328.1 similar to phosphoglycerate mutase [Streptococcus pyogenes MGAS5005] YP_002996329.1 similar to conserved hypothetical protein; integral membrane protein [Streptococcus mutans UA159] YP_002996330.1 similar to transcription regulator [Streptococcus pyogenes MGAS8232] YP_002996331.1 similar to hypothetical protein SpyM51364 [Streptococcus pyogenes str.Manfredo] YP_002996332.1 similar to N-acetylmuramoyl-L-alanine amidase [Streptococcus pyogenes MGAS10750] YP_002996333.1 similar to integral membrane protein [Streptococcus pyogenes MGAS10750] YP_002996334.1 similar to hypothetical protein MGAS10270 Spy0496 [Streptococcus pyogenes MGAS10270] YP_002996335.1 similar to glutathione peroxidase [Streptococcus pyogenes MGAS5005] YP_002996336.1 similar to oligoendopeptidase F [Streptococcus pyogenes MGAS5005] YP_002996337.1 catalyzes the formation of oxaloacetate from phosphoenolpyruvate YP_002996338.1 similar to cell division protein [Streptococcus pyogenes MGAS5005] YP_002996339.1 similar to DNA-directed RNA polymerase specialized sigma subunit [Streptococcus suis 98HAH33] YP_002996340.1 similar to hypothetical protein Sez 1324 [Streptococcus equi subsp. zooepidemicus MGCS10565] YP_002996341.1 EF-Tu; promotes GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis; when the tRNA anticodon matches the mRNA codon, GTP hydrolysis results; the inactive EF-Tu-GDP leaves the ribosome and release of GDP is promoted by elongation factor Ts; many prokaryotes have two copies of the gene encoding EF-Tu YP_002996342.1 similar to hypothetical protein SAG1552 [Streptococcus agalactiae 2603V/R] YP_002996343.1 similar to hypothetical protein gbs1605 [Streptococcus agalactiae NEM316] YP_002996344.1 similar to glycosyl transferase group 2 family protein [Streptococcus agalactiae 2603V/R] YP_002996345.1 Reversibly isomerizes the ketone sugar dihydroxyacetone phosphate to the aldehyde sugar glyceraldehyde-3-phosphate YP_002996346.1 similar to transposase [Streptococcus thermophilus LMD-9] YP_002996347.1 similar to ORFA transposon ISSsa1 [Streptococcus sanguinis SK36] YP_002996348.1 similar to transposase [Streptococcus pyogenes MGAS10394] YP_002996349.1 similar to ISSdy1 transposase OrfB [Streptococcus agalactiae 2603V/R] YP_002996350.1 similar to hypothetical protein gbs1310 [Streptococcus agalactiae NEM316] YP_002996351.1 similar to L-lactate dehydrogenase (FMN-dependent) related alpha-hydroxy acid dehydrogenase [Pediococcus pentosaceus ATCC 25745] YP_002996352.1 similar to factor essential for expression of methicillin resistance [Streptococcus pyogenes MGAS5005] YP_002996353.1 similar to UDP-N-acetylmuramoylpentapeptide-lysine N(6)-alanyltransferase/UDP-N-acetylmuramoyl pentapeptide-lysine N(6)-seryltransferase [Streptococcus pyogenes MGAS5005] YP_002996354.1 similar to HAD superfamily hydrolase [Streptococcus pyogenes MGAS9429] YP_002996355.1 similar to dGTP triphosphohydrolase [Streptococcus pyogenes MGAS5005] YP_002996356.1 similar to hypothetical cytosolic protein [Streptococcus pyogenes MGAS5005] YP_002996357.1 similar to calcium-transporting ATPase [Streptococcus pyogenes M1GAS] YP_002996358.1 similar to LacI family transcription regulator [Streptococcus pyogenes MGAS10394] YP_002996359.1 similar to oligohyaluronate lyase [Streptococcus pyogenes MGAS5005] YP_002996360.1 similar to N-acetylgalactosamine-specific phosphotransferase system (PTS) YP_002996361.1 similar to PTS system N-acetylgalactosamine-specific IIC component [Streptococcus pyogenes MGAS5005] YP_002996362.1 similar to PTS system N-acetylgalactosamine-specific IIB component [Streptococcus pyogenes str. Manfredo] YP_002996363.1 similar to glucuronyl hydrolase [Streptococcus pyogenes MGAS5005] YP_002996364.1 similar to N-acetylgalactosamine-specific phosphotransferase system (PTS) YP_002996365.1 similar to hypothetical protein M5005 Spy 0523 [Streptococcus pyogenes MGAS5005] YP_002996366.1 Involved in the nonphosphorylative, ketogenic oxidation of glucose and oxidizes gluconate to 5-ketogluconate YP_002996367.1 similar to hypothetical protein M5005 Spy 0525 [Streptococcus pyogenes MGAS5005] YP_002996368.1 similar to 2-dehydro-3-deoxygluconokinase [Streptococcus pyogenes MGAS5005] YP_002996369.1 catalyzes the formation of pyruvate and glyoxylate from 4-hydroxy-2-oxoglutarate; or pyruvate and D-glyceraldehyde 3-phosphate from 2-dehydro-3-deoxy-D-glyconate 6-phosphate YP_002996370.1 similar to hyaluronatelyase precursor HylB [Streptococcus equi subsp. zooepidemicus MGCS10565] YP_002996371.1 similar to hypothetical protein SSA 0868 [Streptococcus sanguinis SK36] YP_002996372.1 similar to hypothetical protein SAG0515 [Streptococcus agalactiae 2603V/R] YP_002996373.1 similar to transposase [Streptococcus pyogenes str. Manfredo] YP_002996374.1 similar to probable transposase TnpA (fragment) [Streptococcus pyogenes MGAS315] YP_002996375.1 similar to beta-phosphoglucomutase [Streptococcus pyogenes MGAS10394] YP_002996376.1 similar to fructose-16-bisphosphatase [Streptococcus agalactiae 515] YP_002996377.1 similar to iron-sulfur cluster-binding protein [Streptococcus pyogenes MGAS10394] YP_002996378.1 recognizes the termination signals UGA and UAA during protein translation a specificity which is dependent on amino acid residues residing in loops of the L-shaped tRNA-like molecule of RF2; in some organisms control of PrfB protein levels is maintained through a +1 ribosomal frameshifting mechanism; this protein is similar to release factor 1 YP_002996379.1 similar to cell division ATP-binding protein [Streptococcus pyogenes MGAS5005] YP_002996380.1 similar to cell-division protein [Streptococcus pyogenes MGAS8232] YP_002996381.1 similar to Zn-dependenthydrolase including glyoxylases [Streptococcus suis05ZYH33] YP_002996382.1 unwinds DNA YP_002996383.1 catalyzes the formation of oxalozcetate and L-glutamate from L-aspartate and 2-oxoglutarate YP_002996384.1 catalyzes a two-step reaction, first charging an asparagine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA YP_002996385.1 similar to hypothetical protein SMU.1307c [Streptococcus mutans UA159] YP_002996386.1 similar to P-loop ATPase protein family protein [Streptococcus pyogenes str. Manfredo] YP_002996387.1 similar to transporter [Streptococcus pyogenes MGAS5005] YP_002996388.1 similar to hypothetical cytosolic protein [Streptococcus pyogenes MGAS5005] YP_002996389.1 similar to dipeptidase [Streptococcus pyogenes MGAS5005] YP_002996390.1 similar to high-affinity zinc uptake system protein znuA precursor [Streptococcus pyogenes MGAS5005] YP_002996391.1 similar to transcriptional regulatorGntR family [Streptococcus pyogenes MGAS10750] YP_002996392.1 similar to galactosamine-6-phosphate deaminase (isomerizing) [Streptococcus pyogenes MGAS5005] YP_002996393.1 similar to tagatose1,6-diphosphate aldolase [Streptococcus pyogenes MGAS5005] YP_002996394.1 similar to transcriptional regulator [Streptococcus suis05ZYH33] YP_002996395.1 similar to beta-galactosidase [Streptococcus suis89/1591] YP_002996396.1 similar to PTS systemmannose/fructose IIB component [Streptococcus equi subsp. zooepidemicus MGCS10565] YP_002996397.1 similar to PTS system IIC component [Streptococcus pneumoniae TIGR4] YP_002996398.1 similar to phosphotransferase system, mannose/fructose /N-acetylgalactosamine-specific component IID [Streptococcus suis 05ZYH33] YP_002996399.1 similar to PTS system fructosesubfamily IIA component [Streptococcus suis 89/1591] YP_002996400.1 RpmE2; there appears to be two types of ribosomal proteins L31 in bacterial genomes; some contain a CxxC motif while others do not; Bacillus subtilis has both types; the proteins in this cluster do not have the CXXC motif; RpmE is found in exponentially growing Bacilli while YtiA was found after exponential growth; expression of ytiA is controlled by a zinc-specific transcriptional repressor; RpmE contains one zinc ion and a CxxC motif is responsible for this binding; forms an RNP particle along with proteins L5, L18, and L25 and 5S rRNA; found crosslinked to L2 and L25 and EF-G; may be near the peptidyltransferase site of the 50S ribosome YP_002996401.1 similar to transposase [Streptococcus pyogenes MGAS8232] YP_002996402.1 similar to transposase [Streptococcus pyogenes MGAS10394] YP_002996403.1 similar to transposase [Streptococcus pyogenes SSI-1] YP_002996404.1 similar to transposase [Streptococcus pyogenes MGAS10270] YP_002996405.1 similar to phosphoesterase DHH family protein [Streptococcus pyogenes MGAS10394] YP_002996406.1 similar to GCN5-related N-acetyltransferase [Actinobacillus succinogenes 130Z] YP_002996407.1 similar to glutathione S-transferase family [Streptococcus thermophilus LMG 18311] YP_002996408.1 similar to adenosine deaminase [Streptococcus thermophilus LMG 18311] YP_002996409.1 An electron-transfer protein; flavodoxin binds one FMN molecule, which serves as a redox-active prosthetic group YP_002996410.1 similar to hypothetical protein spyM18 0789 [StreptococcuspyogenesMGAS8232] YP_002996411.1 similar to chloride channel protein [Streptococcus pyogenesMGAS5005] YP_002996412.1 this protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site YP_002996413.1 similar to cell division protein FtsW [Streptococcus equi subsp. zooepidemicus MGCS10565] YP_002996414.1 similar to DNA gyrase related protein [Streptococcus pyogenes MGAS10394] YP_002996415.1 negatively supercoils closed circular double-stranded DNA YP_002996416.1 acts to negatively regulates ftsZ ring formation by modulating the frequency and position of the ftsZ ring formation YP_002996417.1 similar to phosphoserine phosphatase [Streptococcus thermophilus LMG 18311] YP_002996418.1 similar to hypothetical cytosolic protein [Streptococcus pyogenes MGAS10394] YP_002996419.1 enolase; catalyzes the formation of phosphoenolpyruvate from 2-phospho-D-glycerate in glycolysis YP_002996420.1 similar to bacteriocin-like prepropeptide[Streptococcus dysgalactia subsp. equisimilis]; streptolysin S YP_002996421.1 similar to SagB [Streptococcus dysgalactiae subsp. equisimilis] YP_002996422.1 similar to streptolysin S biosynthesis protein [Streptococcus pyogenes MGAS5005] YP_002996423.1 similar to streptolysin Sbiosynthesis protein SagD [Streptococcus pyogenesMGAS10270] YP_002996424.1 similar to streptolysin S self-immunity protein [Streptococcus pyogenes MGAS5005] YP_002996425.1 similar to streptolysin S biosynthesis protein SagF [Streptococcus pyogenes MGAS10270] YP_002996426.1 similar to streptolysin S export ATP-binding protein [Streptococcus pyogenes MGAS5005] YP_002996427.1 similar to streptolysin S export transmembrane protein [Streptococcus pyogenes MGAS6180] YP_002996428.1 similar to streptolysin S export transmembrane protein [Streptococcus pyogenes MGAS5005] YP_002996429.1 similar to endonuclease/exonuclease /phosphatase family protein[Streptococcus pyogenes MGAS9429] YP_002996430.1 similar to hypothetical membrane spanning protein [Streptococcus pyogenes MGAS6180] YP_002996431.1 this protein catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction; essential for DNA replication and repair of damaged DNA; similar to ligase LigB YP_002996432.1 similar to YegS from E. coli YP_002996433.1 pullulanase; similar to glycogen branching enzyme [Streptococcus mutans UA159] YP_002996434.1 catalyzes the transfer of a segment of a 1,4-alpha-D-glucan chain to a primary hydroxy group in a similar glucan chain YP_002996435.1 catalyzes the formation of ADP-glucose and diphosphate from ATP and alpha-D-glucose 1-phosphate YP_002996436.1 similar to glucose-1-phosphate adenylyltransferase GlgC [Streptococcus equi subsp. zooepidemicus MGCS10565] YP_002996437.1 catalyzes the formation of alpha-1,4-glucan chains from ADP-glucose YP_002996438.1 produces ATP from ADP in the presence of a proton gradient across the membrane; subunit C is part of the membrane proton channel F0 YP_002996439.1 Produces ATP from ADP in the presence of a proton gradient across the membrane. Subunit A is part of the membrane proton channel F0 YP_002996440.1 Produces ATP from ADP in the presence of a proton gradient across the membrane. Subunit B is part of the membrane proton channel. YP_002996441.1 Produces ATP from ADP in the presence of a proton gradient across the membrane; the delta subunit is part of the catalytic core of the ATP synthase complex YP_002996442.1 produces ATP from ADP in the presence of a proton gradient across the membrane; the alpha chain is a catalytic subunit YP_002996443.1 Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is a regulatory subunit YP_002996444.1 Produces ATP from ADP in the presence of a proton gradient across the membrane. The beta chain is a regulatory subunit YP_002996445.1 part of catalytic core of ATP synthase; alpha(3)beta(3)gamma(1)delta(1)epsilon(1); involved in producing ATP from ADP in the presence of the proton motive force across the membrane YP_002996446.1 adds enolpyruvyl to UDP-N-acetylglucosamine as a component of cell wall formation; gram-positive bacteria have 2 copies of MurA which are active YP_002996447.1 similar to DNA-entry nuclease [Streptococcus pyogenes MGAS10394] YP_002996448.1 catalyzes a two-step reaction, first charging a phenylalanine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; forms a heterotetramer of alpha(2)beta(2); binds two magnesium ions per tetramer; type 1 subfamily YP_002996449.1 catalyzes a two-step reaction, first charging a phenylalanine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; forms a tetramer of alpha(2)beta(2); binds two magnesium ions per tetramer; type 2 subfamily YP_002996450.1 similar to salt-stress induced protein [Streptococcus pyogenes MGAS10750] YP_002996451.1 similar to hypothetical protein MGAS10750 Spy0675 [Streptococcus pyogenes MGAS10750] YP_002996452.1 similar to hypothetical protein spyM18 0830 [Streptococcus pyogenes MGAS8232] YP_002996453.1 similar to ABC transporter permease protein [Streptococcus pyogenes MGAS10270] YP_002996454.1 similar to ABC transporter ATP-binding protein [Streptococcus pyogenes MGAS6180] YP_002996455.1 similar to neutral zinc metallopeptidase family [Streptococcus pyogenes MGAS10394] YP_002996456.1 similar to ATP-dependent nuclease subunit B [Streptococcus pyogenes MGAS5005] YP_002996457.1 similar to ATP-dependent nuclease subunit A [Streptococcus pyogenes MGAS10394] YP_002996458.1 associated with arginine deiminase pathway genes; probably functions in arginine catabolism YP_002996459.1 similar to arginine-binding protein [Streptococcus pyogenes MGAS2096] YP_002996460.1 a small basic protein that is one of the last in the subunit assembly; omission does not prevent assembly but the subunit is inactive; binds central domain of 16S rRNA YP_002996461.1 similar to large-conductance mechanosensitive channel [Streptococcus pyogenes MGAS5005] YP_002996462.1 synthesizes RNA primers at the replication forks YP_002996463.1 sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released; primary sigma factor of bacterium YP_002996464.1 similar to hypothetical cytosolic protein [Streptococcus pyogenes MGAS5005] YP_002996465.1 similar to dTDP-4-dehydrorhamnose reductase [Streptococcus pyogenes MGAS10394] YP_002996466.1 similar to alpha-(1,2)- rhamnosyltransferase[Streptococcus pyogenes MGAS5005] YP_002996467.1 similar to alpha-L-Rhaalpha-13-L- rhamnosyltransferase[Streptococcus pyogenes MGAS5005] YP_002996468.1 similar to polysaccharide ABC exporter membrane-spanning protein [Streptococcus thermophilus LMG 18311] YP_002996469.1 similar to ABC-type polysaccharide/polyolphosphatetransport system ATPase component [Streptococcus thermophilus LMD-9] YP_002996470.1 similar to glycosyl transferase family protein [Anabaena variabilis ATCC29413] YP_002996471.1 similar to glycosyl transferase [Leifsonia xyli subsp. xyli str. CTCB07] YP_002996472.1 similar to rhamnosyltransferase [Leifsonia xyli subsp. xyli str. CTCB07] YP_002996473.1 similar to hypothetical protein str1466 [Streptococcus thermophilus CNRZ1066] YP_002996474.1 similar to glycosyltransferase involved in cell wall biogenesis [Streptococcus thermophilus LMD-9] YP_002996475.1 similar to glycosyltransferase [Streptococcus equi subsp. zooepidemicus MGCS10565] YP_002996476.1 lytic transglycosylase, dTDP-4-rhamnose reductase; similar to glycosyltransferase lytictransglycosylase dTDP-4-rhamnosereductase[Streptococcus equi subsp. zooepidemicus MGCS10565] YP_002996477.1 similar to phosphoglycerol transferase [Streptococcusequi subsp. zooepidemicusMGCS10565] YP_002996478.1 similar to UDP-glucose 4-epimerase GalE [Streptococcus equi subsp. zooepidemicus MGCS10565] YP_002996479.1 similar to AmrA [Streptococcus pyogenes MGAS10394] YP_002996480.1 catalyzes the release of the N-terminal amino acid from a tripeptide YP_002996481.1 similar to pore forming protein EbsA [Streptococcus pyogenes MGAS10750] YP_002996482.1 similar to ferredoxin [Streptococcus pyogenes MGAS10750] YP_002996483.1 similar to hypothetical protein SPs1318 [Streptococcus pyogenes SSI-1] YP_002996484.1 Catalyzes the formation of (d)CDP from ATP and (d)CMP YP_002996485.1 IF-3 has several functions that are required and promote translation initiation including; preventing association of 70S by binding to 30S; monitoring codon-anticodon interactions by promoting disassociation of fMet-tRNA(fMet) from initiation complexes formed on leaderless mRNAs or incorrectly bound noninitiatior tRNAs and complexes with noncanonical start sites; stimulates codon-anticodon interactions at P-site; involved in moving mRNA to the P-site; and in recycling subunits YP_002996486.1 similar to 50S ribosomal protein L35 [Streptococcus pyogenes MGAS8232] YP_002996487.1 binds directly to 23S ribosomal RNA prior to in vitro assembly of the 50S ribosomal subunit YP_002996488.1 similar to phosphoglycerol transferase [Streptococcus pyogenes MGAS10394] YP_002996489.1 similar to methyltransferase [Streptococcus pyogenes MGAS5005] YP_002996490.1 catalyzes the dehydration of 3-dehydroquinate to form 3-dehydroshikimate in aromatic amino acid biosynthesis YP_002996491.1 catalyzes the formation of chorismate from 5-O-(1-carboxyvinyl)-3-phosphoshikimate in aromatic amino acid biosynthesis YP_002996492.1 similar to hypothetical cytosolic protein [Streptococcus pyogenes MGAS10750] YP_002996493.1 catalyzes the reduction of 2 glutathione to glutathione disulfide; maintains high levels of reduced glutathione in the cytosol; involved in redox regulation and oxidative defense YP_002996494.1 similar to dihydrofolate synthase [Streptococcus pyogenes MGAS10394] YP_002996495.1 similar to hypothetical protein spyM18 0877 [Streptococcus pyogenes MGAS8232] YP_002996496.1 similar to cysteine desulfurase / selenocysteine lyase [Streptococcus pyogenes MGAS10270] YP_002996497.1 Required for the synthesis of the thiazole moiety YP_002996498.1 similar to capsule biosynthesis protein [Streptococcus pyogenes MGAS5005] YP_002996499.1 similar to transposase [Streptococcus pyogenes MGAS10270] YP_002996500.1 similar to ribosomal protein L21 [Streptococcus agalactiae CJB111] YP_002996501.1 similar to 50S ribosomal protein L21 [Streptococcus pyogenes MGAS5005] YP_002996502.1 similar to hypothetical protein spyM18 0884 [Streptococcus pyogenes MGAS8232] YP_002996503.1 involved in the peptidyltransferase reaction during translation YP_002996504.1 similar to transcriptional regulator YP_002996505.1 lipoprotein signal peptidase; integral membrane protein that removes signal peptides from prolipoproteins during lipoprotein biosynthesis YP_002996506.1 similar to ribosomal large subunit pseudouridine synthase D [Streptococcus pyogenes MGAS5005] YP_002996507.1 similar to membrane-associated alkaline phosphatase [Streptococcus equi subsp. zooepidemicus MGCS10565] YP_002996508.1 regulates pyrimidine biosynthesis by binding to the mRNA of the pyr genes, also has been shown to have uracil phosphoribosyltransferase activity YP_002996509.1 similar to uracil permease [Streptococcus pyogenes MGAS10270] YP_002996510.1 catalyzes production of carbamoyl phosphate from bicarbonate and glutamine in pyrimidine and arginine biosynthesis pathways; forms an octamer composed of four CarAB dimers YP_002996511.1 four CarB-CarA dimers form the carbamoyl phosphate synthetase holoenzyme that catalyzes the production of carbamoyl phosphate; CarB is responsible for the amidotransferase activity YP_002996512.1 similar to periplasmic component of efflux system [Streptococcus pyogenes MGAS10750] YP_002996513.1 similar to ABC transporter ATP-binding protein [Streptococcus pyogenes MGAS6180] YP_002996514.1 similar to ABC transporter permease protein [Streptococcus pyogenes MGAS5005] YP_002996515.1 similar to hypothetical protein Sez 1119 [Streptococcus equi subsp. zooepidemicus MGCS10565] YP_002996516.1 similar to glycerophosphoryl diester phosphodiesterase [Streptococcus pyogenes MGAS6180] YP_002996517.1 binds to lower part of 30S body where it stabilizes two domains; required for efficient assembly of 30S; in Escherichia coli this protein has nuclease activity YP_002996518.1 similar to hypothetical protein spyM18 0901 [Streptococcus pyogenes MGAS8232] YP_002996519.1 similar to cell wall surface anchor family protein [Streptococcus equi subsp. zooepidemicus MGCS10565] YP_002996520.1 Essential for efficient processing of 16S rRNA YP_002996521.1 methylates guanosine-37 in various tRNAs; uses S-adenosyl-L-methionine to transfer methyl group to tRNA YP_002996522.1 similar to thioredoxin reductase [Streptococcus pyogenes MGAS5005] YP_002996523.1 similar to regulatory protein [Streptococcus pyogenes MGAS5005] YP_002996524.1 ketopantoate reductase; catalyzes the NADPH reduction of ketopantoate to pantoate; functions in pantothenate (vitamin B5) biosynthesis YP_002996525.1 similar to DeoR family regulatory protein [Streptococcus pyogenes str. Manfredo] YP_002996526.1 similar to 1-phosphofructokinase [Streptococcus pyogenes MGAS10270] YP_002996527.1 similar to PTS system fructose-specific II ABC component [Streptococcus pyogenes MGAS2096] YP_002996528.1 similar to autolysin [Streptococcus pyogenes MGAS5005] YP_002996529.1 similar to N-acetylmuramidase [Streptococcus pyogenes MGAS10270] YP_002996530.1 similar to hypothetical protein SAG1344 [Streptococcus agalactiae 2603V/R] YP_002996531.1 similar to transposase [Streptococcus pyogenes MGAS10394] YP_002996532.1 similar to DegV family protein [Streptococcus pyogenes MGAS10750] YP_002996533.1 catalyzes the addition and repair of the 3'-terminal CCA sequence in tRNA; these proteins belong to the CCA-adding enzyme subfamily 2 which does not have phosphohydrolase activity YP_002996534.1 similar to ABC transporter ATP-binding protein uup [Streptococcus pyogenes MGAS5005] YP_002996535.1 similar to ABC transporter ATP-binding /permease protein [Streptococcus equi subsp. zooepidemicus MGCS10565] YP_002996536.1 similar to ABC transporter ATP-binding /permease protein [Streptococcusequi subsp.zooepidemicus MGCS10565] YP_002996537.1 converts 2-oxoglutarate to glutamate; in Escherichia coli this enzyme plays a role in glutamate synthesis when the cell is under energy restriction; uses NADPH; forms a homohexamer YP_002996538.1 cleaves off formyl group from N-terminal methionine residues of newly synthesized proteins; binds iron(2+) YP_002996539.1 similar to cell surface 5'-nucleotidase [Streptococcus equi subsp. zooepidemicus MGCS10565] YP_002996540.1 similar to GTP pyrophosphokinase [Streptococcus pyogenes MGAS5005] YP_002996541.1 similar to GTP pyrophosphokinase [Streptococcus pyogenes MGAS10750] YP_002996542.1 similar to two-component response regulator [Streptococcus pyogenes MGAS5005] YP_002996543.1 similar to two component system histidine kinase [Streptococcus pyogenes MGAS6180] YP_002996544.1 similar to ABC-type multidrug transportsystem ATPas and permease component[Streptococcus suis 98HAH33] YP_002996545.1 similar to ABC transporter ATP-binding /permease protein [Streptococcus equi subsp. zooepidemicus MGCS10565] YP_002996546.1 similar to mevalonate kinase [Streptococcus pyogenes MGAS10270] YP_002996547.1 similar to diphosphomevalonate decarboxylase [Streptococcus pyogenes MGAS10394] YP_002996548.1 similar to phosphomevalonate kinase [Streptococcus pyogenes MGAS10270] YP_002996549.1 catalyzes the isomerization of isopentenyl pyrophosphate to dimethylallyl diphosphate YP_002996550.1 similar to transcriptional regulatorp utative [Streptococcus pneumoniae TIGR4] YP_002996551.1 similar to transposase [Streptococcus pyogenes MGAS10270] YP_002996552.1 similar to hypothetical protein lin1204 [Listeria innocua Clip11262] YP_002996553.1 similar to fibronectin-binding protein [Streptococcus equi subsp. zooepidemicus] YP_002996554.1 similar to transcriptional regulator [Streptococcus pneumoniae TIGR4] YP_002996555.1 similar to HMG-CoA reductase [Streptococcus pyogenes MGAS8232] YP_002996556.1 similar to HMG-CoA synthase [Streptococcus pyogenes MGAS8232] YP_002996557.1 similar to transposase [Streptococcus pyogenes MGAS10270] YP_002996558.1 ThyA; catalyzes formation of dTMP and 7,8-dihydrofolate from 5,10-methylenetetrahydrofolate and dUMP; involved in deoxyribonucleotide biosynthesis; there are 2 copies in some Bacilli, one of which appears to be phage-derived YP_002996559.1 similar to dihydrofolate reductase [Streptococcus pyogenes MGAS5005] YP_002996560.1 similar to hypothetical protein Sez 1076 [Streptococcus equisubsp. zooepidemicus MGCS10565] YP_002996561.1 binds and unfolds substrates as part of the ClpXP protease YP_002996562.1 binds guanine nucleotides; in Escherichia coli depletion results in defective cell division and filamentation; in Bacillus subtilis this gene is essential YP_002996563.1 similar to hypothetical protein MGAS10270 Spy0751 [Streptococcus pyogenes MGAS10270] YP_002996564.1 similar to ATP-dependentprotease ATP-binding subunit ClpL [Streptococcus equi subsp.zooepidemicusMGCS10565] YP_002996565.1 similar to transposase [Streptococcus pyogenes MGAS2096] YP_002996566.1 binds the two ribosomal protein L7/L12 dimers and anchors them to the large ribosomal subunit YP_002996567.1 similar to hypothetical protein spyM18 1050 [Streptococcus pyogenes MGAS8232] YP_002996568.1 present in two forms; L12 is normal, while L7 is aminoacylated at the N-terminal serine; the only multicopy ribosomal protein; 4:1 ratio of L7/L12 per ribosome; two L12 dimers bind L10; critically important for translation efficiency and fidelity; stimulates GTPase activity of translation factors YP_002996569.1 similar to DD-carboxypeptidase penicillin-binding protein [Streptococcus pyogenes MGAS8232] YP_002996570.1 similar to polysaccharide deacetylase [Streptococcus pyogenes MGAS2096] YP_002996571.1 similar to homoserine dehydrogenase [Streptococcus suis 89/1591] YP_002996572.1 similar to homoserine kinase [Streptococcus pneumoniae D39] YP_002996573.1 similar to folylpolyglutamate synthase / dihydrofolate synthase [Streptococcus pyogenes MGAS10270] YP_002996574.1 involved in the first step of tetrahydrofolate biosynthesis; catalyzes the formation of formate and 2-amino-4-hydroxy-6-(erythro-1,2, 3-trihydroxypropyl)dihydropteridine triphosphate from GTP and water; forms a homopolymer YP_002996575.1 similar to dihydropteroate synthase [Streptococcus pyogenes] YP_002996576.1 similar to dihydroneopterin aldolase [Streptococcus pyogenes MGAS5005] YP_002996577.1 similar to hydroxymethylpterin pyrophosphokinase [Streptococcus pyogenes] YP_002996578.1 catalyzes the reduction of UDP-N-acetylglucosamine enolpyruvate to form UDP-N-acetylmuramate in peptidoglycan biosynthesis YP_002996579.1 similar to PotA [Streptococcus pyogenes MGAS10394] YP_002996580.1 similar to PotB [Streptococcus pyogenes MGAS10394] YP_002996581.1 similar to spermidine/putrescine transport system permease protein [Streptococcus pyogenes MGAS5005] YP_002996582.1 similar to spermidine/putrescine extracellular binding protein [Streptococcus pyogenes str. Manfredo] YP_002996583.1 similar to two-component response regulator [Streptococcus pyogenes MGAS8232] YP_002996584.1 similar to sensor kinase dpiB [Streptococcus pyogenes MGAS10750] YP_002996585.1 similar to L-malate permease [Streptococcus pyogenes MGAS315] YP_002996586.1 similar to NAD-dependent malic enzyme [Streptococcus pyogenes NZ131] YP_002996587.1 similar to chloride channel protein [Streptococcus pyogenes MGAS2096] YP_002996588.1 similar to hypothetical protein STRINF 01402 [Streptococcus infantarius subsp. infantarius ATCC BAA-102] YP_002996589.1 similar to lipase /acylhydrolase family protein [Streptococcus pyogenes MGAS5005] YP_002996590.1 similar to hypothetical protein SPy 1117 [Streptococcus pyogenes M1 GAS] YP_002996591.1 Involved in DNA double-strand break repair and recombination. Promotes the annealing of complementary single-stranded DNA and by simulation of RAD51 recombinase YP_002996592.1 similar to glutamine amidotransferase classI [Streptococcus pyogenes MGAS5005] YP_002996593.1 modulates transcription in response to the NADH/NAD(+) redox state YP_002996594.1 similar to hypothetical protein stu1191 [Streptococcus thermophilus LMG 18311] YP_002996595.1 similar to hypothetical protein Sez 1049 [Streptococcus equi subsp. zooepidemicus MGCS10565] YP_002996596.1 similar to cysteine desulfhydrase [Streptococcus pyogenes MGAS5005] YP_002996597.1 catalyzes the formation of 5-phospho-alpha-D-ribose 1-phosphate from D-ribose 5-phosphate and ATP YP_002996598.1 similar to adenylate cyclase family [Streptococcus pyogenes MGAS10394] YP_002996599.1 similar to GTP pyrophosphokinase [Streptococcus pyogenes MGAS5005] YP_002996600.1 catalyzes the phosphorylation of NAD to NADP YP_002996601.1 similar to ribosomal large subunit pseudouridine synthase D [Streptococcus pyogenes MGAS10394] YP_002996602.1 in Salmonella this enzyme is required for ethanolamine catabolism; has higher affinity for CoA than Pta YP_002996603.1 similar to short chain dehydrogenase [Streptococcus pyogenes MGAS10394] YP_002996604.1 similar to Na+ driven multidrug efflux pump [Streptococcus pyogenes MGAS10270] YP_002996605.1 similar to ABC transporter (ATP-binding protein) [Streptococcus pyogenes MGAS315] YP_002996606.1 similar to glycine betaine transport system permease protein [Streptococcus pyogenes MGAS5005] YP_002996607.1 similar to guanosine 5'-monophosphate oxidoreductase [Streptococcus pyogenes MGAS5005] YP_002996608.1 Catalyzes the transfer of the phosphoribosyl moiety from 5-phospho--D-ribosyl-1-pyrophosphate (PRib-PP) to the 6-oxo-guanine and -xanthine YP_002996609.1 similar to xanthine permease [Streptococcus pyogenes MGAS10270] YP_002996610.1 similar to iron-sulfur cluster assembly /repair protein ApbE [Streptococcus pyogenes MGAS10270] YP_002996611.1 4-OT; member of subfamily 5; forms a dimer; the function in the Escherichia coli cell is unknown YP_002996612.1 similar to thymidine kinase Tdk [Streptococcus equi subsp. zooepidemicus MGCS10565] YP_002996613.1 recognizes the termination signals UAG and UAA during protein translation a specificity which is dependent on amino acid residues residing in loops of the L-shaped tRNA-like molecule of RF1; this protein is similar to release factor 2 YP_002996614.1 similar to peptide release factor-glutamine N5-methyltransferase [Streptococcus pyogenes MGAS5005] YP_002996615.1 similar to Sua5/YciO/YrdC/YwlC family protein [Streptococcus pyogenes MGAS10750] YP_002996616.1 similar to COG0454, Histone acetyltransferase HPA2 and related acetyltransferases [Streptococcus pyogenes M49 591] YP_002996617.1 catalyzes the reaction of glycine with 5,10-methylenetetrahydrofolate to form L-serine and tetrahydrofolate YP_002996618.1 similar to hypothetical protein M5005 Spy 0868 [Streptococcus pyogenes MGAS5005] YP_002996619.1 similar to antigen [Streptococcus pyogenes MGAS5005] YP_002996620.1 similar to multidrug resistance ABC transporter ATP-binding and permease protein [Streptococcus pyogenes MGAS10750] YP_002996621.1 similar to ABC transporter ATP-binding membrane protein [Streptococcus pyogenes str. Manfredo] YP_002996622.1 similar to NADH oxidase [Streptococcus pyogenes M1 GAS] YP_002996623.1 similar to dihydrofolate reductase [Streptococcus suis 98HAH33] YP_002996624.1 Converts (S)-lactate and NAD(+) to pyruvate and NADH YP_002996625.1 negatively supercoils closed circular double-stranded DNA YP_002996626.1 similar to sortase [Streptococcus pyogenes NZ131] YP_002996627.1 similar to lactoylglutathione lyase [Streptococcus pyogenes MGAS10394] YP_002996628.1 probable ORF of N-terminal portion of the Lmb protein [Streptococcus dysgalactiae subsp. equisimilis] resulted from mutation by unknown reason YP_002996629.1 probable ORF of middlel portion of the Lmb protein [Streptococcus dysgalactiae subsp. equisimilis] resulted from mutation by unknown reason YP_002996630.1 probable ORF of C-terminal portion of the Lmb protein [Streptococcus dysgalactiae subsp. equisimilis] resulted from mutation by unknown reason YP_002996631.1 similar to histidine triad protein HtpA [Streptococcus equi subsp. zooepidemicus MGCS10565] YP_002996632.1 similar to extracellular protein [Streptococcus equi subsp. zooepidemicus MGCS10565] YP_002996633.1 similar to transposase [Streptococcus pyogenes MGAS10750] YP_002996634.1 similar to ISSdy1, transposase OrfB [Streptococcus agalactiae 2603V/R] YP_002996635.1 similar to ISSag4, transposase OrfA [Streptococcus agalactiae A909] YP_002996636.1 similar to hypothetical protein M6 Spy1729 [Streptococcus pyogenes MGAS10394] YP_002996637.1 similar to periplasmic component of efflux system [Streptococcus pyogenes MGAS5005] YP_002996638.1 similar to ABC transporter ATP-binding protein [Streptococcus pyogenes MGAS5005] YP_002996639.1 similar to ABC transporter permease protein [Streptococcus pyogenes MGAS5005] YP_002996640.1 similar to two-component response regulator [Streptococcus pyogenes MGAS5005] YP_002996641.1 similar to two component system histidine kinase [Streptococcus pyogenes MGAS5005] YP_002996642.1 similar to immunogenic secreted protein [Streptococcus pyogenes MGAS10270] YP_002996643.1 similar to hypothetical protein M28 Spy1706 [Streptococcus pyogenes MGAS6180] YP_002996644.1 similar to hypothetical protein CdifQCD-6 20778 [Clostridium difficile QCD-63q42] YP_002996645.1 similar to complement inhibitor protein [Streptococcus pyogenes MGAS2096] YP_002996646.1 similar to streptococcal C5a peptidase [Streptococcus agalactiae NEM316] YP_002996647.1 similar to hypothetical protein MGAS9429 Spy1719 [Streptococcus pyogenes MGAS9429] YP_002996648.1 similar to laminin binding protein [Streptococcus pyogenes MGAS5005] YP_002996649.1 similar to streptococcal histidine triad protein [Streptococcus pyogenes MGAS10394] YP_002996650.1 similar to hypothetical protein [Streptococcus suis] YP_002996651.1 similar to CsbD-like protein [Streptococcus pyogenes str. Manfredo] YP_002996652.1 similar to dipeptide transport ATP-binding protein [Streptococcus pyogenes MGAS5005] YP_002996653.1 similar to dipeptide transport ATP-binding protein [Streptococcus pyogenes MGAS5005] YP_002996654.1 similar to dipeptide transport system permease protein [Streptococcus pyogenes MGAS5005] YP_002996655.1 similar to dipeptide transport system permease protein [Streptococcus pyogenes MGAS5005] YP_002996656.1 similar to dipeptide-binding protein [Streptococcus pyogenes MGAS5005] YP_002996657.1 similar to dipeptide-binding protein [Streptococcus pyogenes MGAS10394] YP_002996658.1 similar to transposase [Streptococcus pyogenes MGAS10394] YP_002996659.1 similar to transposase [Streptococcus pyogenes MGAS10394] YP_002996660.1 similar to UDP-N-acetylmuramoylpentapeptide-lysine N(6)-alanyltransferase / UDP-N-acetylmuramoylpentapeptide-lysine N(6)-seryltransferase [Streptococcus pyogenes MGAS10750] YP_002996661.1 similar to Na+/H+ antiporter [Streptococcus agalactiae A909] YP_002996662.1 similar to IS1562 transposase [Streptococcus pyogenes MGAS8232] YP_002996663.1 similar to transposase [Streptococcus pyogenes MGAS10750] YP_002996664.1 similar to transposase [Streptococcus pyogenes MGAS10750] YP_002996665.1 similar to hypothetical protein CKL 3238 [Clostridium kluyveri DSM 555] YP_002996666.1 similar to Type II restriction enzyme EcoRI [Parabacteroides distasonis ATCC 8503] YP_002996667.1 similar to type II restriction enzyme EcoRI-like protein [Microcystis aeruginosa NIES-843] YP_002996668.1 similar to transposase [Streptococcus pyogenes MGAS10394] YP_002996669.1 contains glutamine-hydrolyzing domain and glutamine amidotransferase; GMP-binding domain; functions to produce GMP from XMP in the IMP pathway YP_002996670.1 similar to hypothetical protein SpyM50880 [Streptococcus pyogenes str. Manfredo] YP_002996671.1 similar to GntR family transcriptional regulator [Streptococcus pyogenes M1GAS] YP_002996672.1 similar to signal recognition particle associated protein [Streptococcus pyogenes MGAS10750] YP_002996673.1 similar to signal recognition particle subunit FFH/SRP54 [Streptococcus pyogenes MGAS10270] YP_002996674.1 similar to ferric reductase [Oenococcus oeni PSU-1] YP_002996675.1 similar to predicted ferric reductase [Bifidobacterium animalis subsp. lactis HN019] YP_002996676.1 similar to phage transcriptional repressor [Streptococcus equi subsp.z ooepidemicus MGCS10565] YP_002996677.1 similar to oxidoreductase [Lactobacillus plantarum WCFS1] YP_002996678.1 similar to DNA-binding response regulator [Streptococcus agalactiae 2603V/R] YP_002996679.1 similar to sensor histidine kinase [Streptococcus agalactiae 2603V/R] YP_002996680.1 similar to hypothetical protein CAT7 10785 [Carnobacterium sp. AT7] YP_002996681.1 similar to peptido glycan branched peptide synthesis protein, alanine adding enzyme [Streptococcust hermophilus CNRZ1066] YP_002996682.1 similar to peptido glycan branched peptide synthesis protein, alanine adding enzyme [Streptococcus thermophilus CNRZ1066] YP_002996683.1 site-specific tyrosine recombinase which cuts and rejoins DNA molecules; binds cooperatively to specific DNA consensus sites; essential to convert chromosome dimers to monomers during cell division and functions during plasmid segregation; cell division protein FtsK may regulate the XerS YP_002996684.1 similar to hypothetical protein SSU98 1762 [Streptococcus suis 98HAH33] YP_002996685.1 similar to 14-dihydroxy-2-naphthoate octaprenyl transferase [Streptococcus suis 05ZYH33] YP_002996686.1 similar to membrane -associated lipoprotein involved in thiamine biosynthesis [Streptococcus suis 98HAH33] YP_002996687.1 similar to hypothetical protein SSU05 1758 [Streptococcus suis 05ZYH33] YP_002996688.1 similar to TCS senso kinase BceS [Streptococcus equi subsp. zooepidemicus MGCS10565] YP_002996689.1 similar to TCS response regulator BceR [Streptococcus equi subsp. zooepidemicus MGCS10565] YP_002996690.1 similar to bacitracin export permease protein BceB [Streptococcus equi subsp. zooepidemicus MGCS10565] YP_002996691.1 similar to ABC transporter ATP-binding protein [Streptococcus equi subsp. zooepidemicus MGCS10565] YP_002996692.1 similar to nisin-resistanceprotein, [Streptococcus agalactiae 2603V/R] YP_002996693.1 similar to hypothetical protein MGAS10750 Spy1061 [Streptococcus pyogenes MGAS10750] YP_002996694.1 similar to (citrate [pro-3S]-lyase)-ligase [Streptococcus pyogenes MGAS5005] YP_002996695.1 Converts oxaloacetate to phosphoenolpyruvate using ATP as an energy source YP_002996696.1 similar to transposase [Streptococcus pneumoniae SP9-BS68] YP_002996697.1 2'-(5''-phosphoribosyl)-3'-dephospho-CoA transferase; holo-citrate lyase synthase; CitG forms the prosthetic group precursor 2'-(5''-triphosphoribosyl)-3'-dephospho-CoA which is then transferred to apo-ACP by CitX to produce holo-ACP and pyrophosphate YP_002996698.1 similar to citrate CoA-transferase [Streptococcus pyogenes MGAS10394] YP_002996699.1 similar to citrate lyase beta chain [Streptococcus pyogenes MGAS10394] YP_002996700.1 acyl carrier protein; with CitE and CitF catalyzes the formation of oxaloacetate from citrate YP_002996701.1 similar to hypothetical protein M5005 Spy 0904 [Streptococcus pyogenes MGAS5005] YP_002996702.1 similar to oxaloacetate decarboxylase beta chain [Streptococcus pyogenes MGAS5005] YP_002996703.1 composes the biotin carboxyl carrier protein subunit of the acetyl-CoA carboxylase complex, the enzyme that catalyzes the carboxylation of acetyl-CoA to malonyl-CoA, which in turn controls the rate of fatty acid metabolism YP_002996704.1 similar to hypothetical protein MGAS10750 Spy1050 [Streptococcus pyogenes MGAS10750] YP_002996705.1 similar to Mg2+/citrate complex secondary transporter [Streptococcus pyogenes MGAS5005] YP_002996706.1 similar to GntR family transcriptional regulator [Streptococcus pyogenes MGAS5005] YP_002996707.1 similar to 2-(5''-triphosphoribosyl)-3'- dephosphocoenzyme-A synthase [Streptococcus pyogenes MGAS5005] YP_002996708.1 similar to ammonia monooxygenase [Streptococcus equi subsp. zooepidemicus MGCS10565] YP_002996709.1 similar to oxaloacetate decarboxylase beta chain [Streptococcus pyogenes MGAS10394] YP_002996710.1 similar to methylmalonyl-CoA decarboxylase gamma-subunit [Streptococcus pyogenes MGAS315] YP_002996711.1 similar to hypothetical membrane associated protein [Streptococcus pyogenes MGAS10394] YP_002996712.1 Converts oxaloacetate to phosphoenolpyruvate using ATP as an energy source YP_002996713.1 TrmFO; Gid; glucose-inhibited division protein; similar to GidA; the gene from Bacillus subtilis encodes a tRNA-methyltransferase that utilizes folate as the carbon donor and bound flavin as reductant; modifies tRNA at position 54 (uridine) of the T-psi loop to form a C5-methyluridine YP_002996714.1 similar to hypothetical protein MGAS10270 Spy1006 [Streptococcus pyogenes MGAS10270] YP_002996715.1 similar to hypothetical protein MGAS10270 Spy1005 [Streptococcus pyogenes MGAS10270] YP_002996716.1 catalyzes the formation of pyruvate from lactate YP_002996717.1 similar to hypothetical protein SAK 0820 [Streptococcus agalactiae A909] YP_002996718.1 similar to transposase [Streptococcus pyogenes MGAS2096] YP_002996719.1 similar to transcriptional regulator, LysR family [Streptococcus agalactiae H36B] YP_002996720.1 similar to hypothetical protein gbs0666 [Streptococcus agalactiae NEM316] YP_002996721.1 catalyzes the ATP-dependent breakage of single-stranded DNA followed by passage and rejoining, maintains net negative superhelicity YP_002996722.1 similar to DNA processing protein [Streptococcus pyogenes MGAS10750] YP_002996723.1 RNH2; RNase HII; binds manganese; endonuclease which specifically degrades the RNA of RNA-DNA hybrids YP_002996724.1 essential GTPase; functions in ribosome assembly; binds a unique part of the 23S rRNA; interacts with ribosomal protein L25(Ctc) YP_002996725.1 similar to hypothetical protein SPCG 0150 [Streptococcus pneumoniae CGSP14] YP_002996726.1 similar to XRE family transcriptional regulator [Streptococcus thermophilus LMD-9] YP_002996727.1 similar to hypothetical cytosolic protein [Streptococcus pyogenes MGAS10750] YP_002996728.1 similar to hypothetical protein M5005 Spy 0880 [Streptococcus pyogenes MGAS5005] YP_002996729.1 similar to diacylglycerol kinase family protein [Streptococcus pyogenes MGAS2096] YP_002996730.1 similar to hypothetical protein M28 Spy0852 [Streptococcus pyogenes MGAS6180] YP_002996731.1 similar to hypothetical protein MGAS2096 Spy1031 [Streptococcus pyogenes MGAS2096] YP_002996732.1 similar to ABC transporter ATP-binding protein [Streptococcus pyogenes MGAS6180] YP_002996733.1 plasminogen activator; similar to streptokinase precursor [Streptococcus dysgalactiae subsp. equisimilis] YP_002996734.1 similar to hypothetical protein spyM18 1159 [Streptococcus pyogenes MGAS8232] YP_002996735.1 catalyzes the formation of pyridoxal 5'-phosphate from pyridoxal YP_002996736.1 similar to transcriptional regulator YP_002996737.1 similar to hypothetical protein SPs1051 [Streptococcus pyogenes SSI-1] YP_002996738.1 catalyzes the formation of 4-aspartyl phosphate from aspartate 4-semialdehyde YP_002996739.1 similar to cardiolipin synthetase [Streptococcus pyogenes MGAS10394] YP_002996740.1 similar to C5a peptidase precursor ScpZ [Streptococcus equi subsp. zooepidemicusMGCS10565] YP_002996741.1 similar to ISSdy1, transposase OrfB [Streptococcus agalactiae 2603V/R] YP_002996742.1 similar to ISSdy1, transposase OrfA [Streptococcus agalactiae 2603V/R] YP_002996743.1 similar to transposase [Streptococcus agalactiae] YP_002996744.1 similar to transposase [Streptococcus pyogenes str. Manfredo] YP_002996745.1 similar to probable transposase TnpA (fragment) [Streptococcus pyogenes MGAS315] YP_002996746.1 catalyzes the formation of 10-formyltetrahydrofolate from formate and tetrahydrofolate YP_002996747.1 similar to lipoate-protein ligase A [Streptococcus pyogenes MGAS10394] YP_002996748.1 similar to SIR2 family protein [Streptococcus pyogenes MGAS10394] YP_002996749.1 similar to hypothetical protein M5005 Spy 0930 [Streptococcus pyogenes MGAS5005] YP_002996750.1 similar to glycine cleavage system H protein [Streptococcus pyogenes MGAS5005] YP_002996751.1 similar to probable NADH-dependent flavin oxidoreductase [Streptococcus pyogenes MGAS10394] YP_002996752.1 similar to lipoate-protein ligase A [Streptococcus pyogenes MGAS5005] YP_002996753.1 similar to phosphopantothenate-cysteine ligase [Streptococcus pyogenes MGAS10270] YP_002996754.1 decarboxylates 4-phosphopantothenoylcysteine to form 4'-phosphopantotheine. YP_002996755.1 similar to integral membrane protein [Streptococcus pyogenes MGAS10750] YP_002996756.1 similar to phosphomannomutase PgmA [Streptococcusequi subsp. zooepidemicus MGCS10565] YP_002996757.1 similar to nucleoside transport system permease protein [Streptococcus pyogenes MGAS10394] YP_002996758.1 similar to nucleoside transportsystem permease protein [Streptococcus pyogenes MGAS6180] YP_002996759.1 similar to nucleoside transport ATP-binding protein [Streptococcus pyogenes MGAS10270] YP_002996760.1 similar to nucleoside-binding protein [Streptococcus pyogenes MGAS10394] YP_002996761.1 Reclaims exogenous and endogenous cytidine and 2'-deoxycytidine molecules for UMP synthesis YP_002996762.1 catalyzes the formation of D-glyceraldehyde 3-phosphate and acetaldehyde from 2-deoxy-D-ribose-5-phosphate YP_002996763.1 Catalyzes the reversible phosphorolysis of pyrimidines in the nucleotide synthesis salvage pathway YP_002996764.1 similar to 16S rRNA m(2)G 1207 methyltransferase [Streptococcus pyogenes MGAS10750] YP_002996765.1 catalyzes the formation of (R)-4'-phosphopantothenate in coenzyme A biosynthesis YP_002996766.1 binds directly to the 16S rRNA and is involved in post-translational inhibition of arginine and ornithine decarboxylase YP_002996767.1 similar to histidine kinase protein [Streptococcus pyogenes MGAS8232] YP_002996768.1 similar to response regulator [Streptococcus pyogenes MGAS8232] YP_002996769.1 similar to lysyl aminopeptidase / alanine aminopeptidase [Streptococcus pyogenes MGAS10750] YP_002996770.1 similar to phosphate transport system protein [Streptococcus pyogenes MGAS5005] YP_002996771.1 ATP-binding protein; PstABCS is an ATP dependent phosphate uptake system which is responsible for inorganic phosphate uptake during phosphate starvation YP_002996772.1 ATP-binding protein; PstABCS is an ATP dependent phosphate uptake system which is responsible for inorganic phosphate uptake during phosphate starvation YP_002996773.1 similar to phosphate transport system permease protein [Streptococcus pyogenes MGAS5005] YP_002996774.1 similar to phosphate transport system permease protein pstC [Streptococcus pyogenes MGAS10750] YP_002996775.1 similar to phosphate-binding protein [Streptococcus pyogenes MGAS5005] YP_002996776.1 similar to 23S rRNA m(5)C methyltransferase [Streptococcus pyogenes MGAS10750] YP_002996777.1 similar to myo-inositol-1(or 4)-monophosphatase [Streptococcus pyogenes MGAS8232] YP_002996778.1 similar to hypothetical protein M6 Spy0948 [Streptococcus pyogenes MGAS10394] YP_002996779.1 the anti-alpha factor Spx interacts with RNA polymerase alpha subunit C-terminal domain in a region that interacts with the sigma 70 subunit and may interfere with activation of promoters; in Bacillus subtilis this protein is a substrate for ClpXP protease; blocks transcription of the competence regulatory gene encoded by the srf operon; regulates a number of genes involved in thiol homeostasis including trxA and trxB; monomeric member of ArsC family of proteins; does not bind DNA; contains a disulfide bond between C10 and C13 which may sense disulfide stress YP_002996780.1 catalyzes the formation of FMN from riboflavin and the formation of FAD from FMN; in Bacillus the ribC gene has both flavokinase and FAD synthetase activities YP_002996781.1 similar to transposase [Streptococcus criceti] YP_002996782.1 similar to transposase [Streptococcus pyogenes MGAS2096] YP_002996783.1 catalyzes isomerization of specific uridines in RNA to pseudouridine; responsible for residues in T loops of many tRNAs YP_002996784.1 similar to COG4487, uncharacterized protein conserved in bacteria [Streptococcus pyogenes M49 591] YP_002996785.1 similar to integral membrane protein [Streptococcus pyogenes MGAS10750] YP_002996786.1 similar to hypothetical protein SpyM3 0890 [Streptococcus pyogenes MGAS315] YP_002996787.1 similar to ABC transporter permease protein [Streptococcus pyogenes MGAS2096] YP_002996788.1 similar to ABC transporter (ATP-binding protein) [Streptococcus pyogenes MGAS8232] YP_002996789.1 similar to TetR family transcriptional regulator [Streptococcus pyogenes MGAS10270] YP_002996790.1 similar to transcriptional regulator [Streptococcus pyogenes M1 GAS] YP_002996791.1 similar to Gls24 family general stress protein [Streptococcus pyogenes MGAS10394] YP_002996792.1 similar to hypothetical protein SpyM50827 [Streptococcus pyogenes str. Manfredo] YP_002996793.1 similar to hypothetical protein SPy 1263 [Streptococcus pyogenes M1 GAS] YP_002996794.1 similar to hypothetical protein spyM18 1215 [Streptococcus pyogenes MGAS8232] YP_002996795.1 similar to hypothetical protein SpyM50824 [Streptococcus pyogenes str. Manfredo] YP_002996796.1 similar to DNA helicase II [Streptococcus pyogenes MGAS10394] YP_002996797.1 similar to amino acid symporter [Streptococcus pyogenes MGAS315] YP_002996798.1 similar to cobalt-zinc-cadmium resistance protein czcD [Streptococcus pyogenes MGAS10270] YP_002996799.1 similar to transposase [Streptococcus pyogenes MGAS10394] YP_002996800.1 similar to transposase [Streptococcus pyogenes MGAS10394] YP_002996801.1 similar to amino acid ABC transporter extracellular-binding protein precursor [Streptococcus equi subsp. zooepidemicus MGCS10565] YP_002996802.1 similar to histidine transport ATP-binding protein hisP [Streptococcus pyogenes MGAS10750] YP_002996803.1 similar to histidine transport system permease protein hisM [Streptococcus pyogenes MGAS10270] YP_002996804.1 similar to hypothetical protein spyM18 1226 [Streptococcus pyogenes MGAS8232] YP_002996805.1 Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source YP_002996806.1 similar to signal peptidase I [Streptococcus pyogenes MGAS2096] YP_002996807.1 catalyzes the formation of phosphoenolpyruvate from pyruvate YP_002996808.1 catalyzes the formation of D-fructose 1,6-bisphosphate from D-fructose 6-phosphate in glycolysis YP_002996809.1 Catalyzes DNA-template-directed extension of the 3'-end of a DNA strand by one nucleotide at a time. Proposed to be responsible for the synthesis of the lagging strand. In the low GC gram positive bacteria this enzyme is less processive and more error prone than its counterpart in other bacteria. YP_002996810.1 similar to transcriptional regulator GntR family [Streptococcus pyogenes MGAS10750] YP_002996811.1 similar to ABC transporter ATP-binding protein [Streptococcus pyogenes str. Manfredo] YP_002996812.1 similar to hypothetical protein SpyM3 0917 [Streptococcus pyogenes MGAS315] YP_002996813.1 similar to hypothetical protein spyM18 1236 [Streptococcus pyogenes MGAS8232] YP_002996815.1 similar to unknown phage protein [Streptococcus pyogenes MGAS10394] YP_002996816.1 similar to deoxyribonuclease [Streptococcus dysgalactiae subsp. equisimilis] YP_002996817.1 similar to CsbD-like phage protein [Streptococcus pyogenes str. Manfredo] YP_002996818.1 similar to hypothetical protein CGSSp14BS69 08645 [Streptococcus pneumoniae SP14-BS69] YP_002996819.1 similar to lysin [Streptococcus phage P9] YP_002996820.1 similar to hypothetical protein P9 gp49 [Streptococcus phage P9] YP_002996821.1 similar to Holin [Streptococcus pyogenes MGAS10394] YP_002996822.1 similar to phage protein [Streptococcus pyogenes MGAS10750] YP_002996823.1 similar to hypothetical protein spyM18 1755 [Streptococcus pyogenes MGAS8232] YP_002996824.1 similar to hypothetical protein SpyM50681 [Streptococcus pyogenes str. Manfredo] YP_002996825.1 similar to phage protein [Streptococcus phage 10270.2] YP_002996826.1 similar to hyaluronoglucosaminidase [Streptococcus pyogenes MGAS10394] YP_002996827.1 probable C-terminal portion of phage endopeptidase [Streptococcus pyogenes MGAS10394] YP_002996828.1 probable N-terminal portion of phage endopeptidase [Streptococcus pyogenes MGAS10394] YP_002996829.1 similar to hypothetical protein spyM18 1457 [Streptococcus pyogenes MGAS8232] YP_002996830.1 similar to phage protein [Streptococcus pyogenes MGAS5005] YP_002996831.1 similar to endodeoxyribonuclease [Lactococcus phage r1t] YP_002996832.1 similar to N-terminal of phage protein [Streptococcus pyogenes MGAS5005] YP_002996833.1 similar to phage protein [Streptococcus pyogenes MGAS5005] YP_002996834.1 similar to major tail protein [Streptococcus pyogenes MGAS5005] YP_002996835.1 similar to unknown phage protein [Streptococcus pyogenes MGAS10394] YP_002996836.1 similar to unknown phage protein [Streptococcus pyogenes MGAS10394] YP_002996837.1 similar to phage protein [Streptococcus pyogenes MGAS5005] YP_002996838.1 similar to phage protein [Streptococcus pyogenes MGAS5005] YP_002996839.1 similar to conserved hypothetical protein (phage associated) [Streptococcus suis 89/1591] YP_002996840.1 similar to structural protein - phage associated [Streptococcus suis 89 /1591] YP_002996841.1 similar to phage protein [Streptococcus pyogenes MGAS10750] YP_002996842.1 similar to phage terminase [Streptococcus pyogenes MGAS10750] YP_002996843.1 similar to hypothetical protein spyM18 1273 [Streptococcus pyogenes MGAS8232] YP_002996844.1 similar to hypothetical protein MGAS10750 Spy1919 [bacteriophage 10750.4] YP_002996845.1 similar to hypothetical protein SAK 0633 [Streptococcus agalactiae A909] YP_002996846.1 similar to structural phage protein [Streptococcus pyogenes MGAS8232] YP_002996847.1 similar to hypothetical protein spyM18 1482 [Streptococcus pyogenes MGAS8232] YP_002996848.1 similar to HNH endonuclease family protein [Streptococcus pyogenes MGAS5005] YP_002996849.1 similar to hypothetical protein spyM18 1485 [Streptococcus pyogenes MGAS8232] YP_002996850.1 similar to hypothetical protein SpyM3 1125 [Streptococcus pyogenes MGAS315] YP_002996851.1 similar to phage protein [bacteriophage 10750.2] YP_002996852.1 similar to phage protein [bacteriophage 10750.1] YP_002996853.1 similar to phage protein [Streptococcus pyogenes MGAS5005] YP_002996854.1 similar to hypothetical protein spyM18 0734 [Streptococcus pyogenes MGAS8232] YP_002996855.1 similar to phage protein [Streptococcus pyogenes MGAS5005] YP_002996856.1 similar to hypothetical protein spyM18 1494 [Streptococcus pyogenes MGAS8232] YP_002996857.1 similar to hypothetical protein spyM18 0732 [Streptococcus pyogenes MGAS8232] YP_002996858.1 similar to recT protein [Streptococcus pyogenes MGAS5005] YP_002996859.1 similar to hypothetical protein SPy 0956 [Streptococcus phage 370.3] YP_002996860.1 similar to phage protein [Streptococcus pyogenes MGAS10270] YP_002996861.1 similar to hypothetical protein spyM18 1499 [Streptococcus pyogenes MGAS8232] YP_002996862.1 similar to phage DNA replication protein [Streptococcus pyogenes str. Manfredo] YP_002996863.1 similar to phage replication protein [Streptococcus pyogenes MGAS5005] YP_002996864.1 similar to hypothetical protein SPy 0952 [Streptococcus phage 370.3] YP_002996865.1 similar to phage protein [Streptococcus pyogenes MGAS6180] YP_002996866.1 similar to unknown phage protein [Streptococcus pyogenes MGAS10394] YP_002996867.1 similar to phage protein [Streptococcus pyogenes phage 5005.3] YP_002996868.1 similar to hypothetical protein SpyM50635 [Streptococcus pyogenes str. Manfredo] YP_002996869.1 similar to phage DNA-binding protein [Streptococcus pyogenes str. Manfredo] YP_002996870.1 similar to hypothetical protein SpyM50633 [Streptococcus pyogenes str. Manfredo] YP_002996871.1 similar to hypothetical protein CGSSp6BS73 08144 [Streptococcus pneumoniae SP6-BS73] YP_002996872.1 similar to hypothetical protein CGSSp6BS73 08139 [Streptococcus pneumoniae SP6-BS73] YP_002996873.1 similar to integrase [Streptococcus pyogenes MGAS8232] YP_002996874.1 similar to hypothetical protein M5005 Spy 1054 [Streptococcus pyogenes phage 5005.1] YP_002996875.1 similar to transposase [Streptococcus pyogenes MGAS10394] YP_002996876.1 similar to transposase; Phage-associated cell wall hydrolase [Streptococcus pyogenes MGAS10394] YP_002996877.1 in Escherichia coli this protein is involved in binding to the leader sequence of mRNAs and is itself bound to the 30S subunit; autoregulates expression via a C-terminal domain; in most gram negative organisms this protein is composed of 6 repeats of the S1 domain while in gram positive there are 4 repeats; the S1 nucleic acid-binding domain is found associated with other proteins YP_002996879.1 similar to hypothetical cytosolic protein [Streptococcus pyogenes MGAS10750] YP_002996880.1 catalyzes the transamination of the branched-chain amino acids to their respective alpha-keto acids YP_002996881.1 similar to transposase [Streptococcus pyogenes MGAS10394] YP_002996882.1 decatenates newly replicated chromosomal DNA and relaxes positive and negative DNA supercoiling YP_002996883.1 similar to hypothetical protein MGAS10270 Spy0770 [Streptococcus pyogenes MGAS10270] YP_002996884.1 decatenates newly replicated chromosomal DNA and relaxes positive and negative DNA supercoiling YP_002996885.1 involved in acylation of glycerol-3-phosphate to form 1-acyl-glycerol-3 phosphate for use in phospholipid biosynthesis; functions with PlsX YP_002996886.1 catalyzes the formation of N-carbamoyl-L-aspartate from (S)-dihydroorotate in pyrimidine biosynthesis YP_002996887.1 Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine YP_002996888.1 similar to cystine transport system permease protein [Streptococcus pyogenes MGAS5005] YP_002996889.1 similar to cystine-binding protein [Streptococcus pyogenes MGAS10394] YP_002996890.1 catalyzes the hydrolysis of a monocarboxylic acid amid to form a monocarboxylate and ammonia YP_002996891.1 similar to transposase IS861 orfB [Streptococcus equi subsp. zooepidemicus MGCS10565] YP_002996892.1 similar to transposase IS861 orfA [Streptococcus equi subsp. zooepidemicus MGCS10565] YP_002996893.1 similar to acetyltransferase GNAT family [Streptococcus equi subsp. zooepidemicus MGCS10565] YP_002996894.1 similar to Orotate phosphoribosyltransferase [Streptococcus thermophilus LMD-9] YP_002996895.1 type 1 subfamily; involved in last step of pyrimidine biosynthesis; converts orotidine 5'-phosphate to UMP and carbon dioxide; OMP decarboxylase; OMPDCase; OMPdecase YP_002996896.1 similar to hypothetical protein M5005 Spy 0702 [Streptococcus pyogenes MGAS5005] YP_002996897.1 similar to transcriptional regulators LysR family [Streptococcus pyogenes MGAS2096] YP_002996898.1 similar to attenuator of transcription LytR family regulator [Streptococcus pyogenes MGAS6180] YP_002996899.1 catalyzes the reversible phosphorolysis of ribonucleosides and 2'- deoxyribonucleosides to the free base and (2'-deoxy)ribose-1- phosphate YP_002996900.1 catalyzes the formation of a purine and ribose phosphate from a purine nucleoside; in E. coli this enzyme functions in xanthosine degradation YP_002996901.1 similar to arsenate reductase [Streptococcus pyogenes MGAS10750] YP_002996902.1 catalyzes the transfer of phosphate between the C1 and C5 carbons of pentose YP_002996903.1 Catalyzes D-ribose 5-phosphate --> D-ribulose 5-phosphate in the nonoxidative branch of the pentose phosphate pathway YP_002996904.1 in Escherichia coli this protein is involved in the biosynthesis of the hypermodified nucleoside 5-methylaminomethyl-2-thiouridine, which is found in the wobble position of some tRNAs and affects ribosomal frameshifting; shows potassium-dependent dimerization and GTP hydrolysis; also involved in regulation of glutamate-dependent acid resistance and activation of gadE YP_002996905.1 divalent metal ion-dependent extracellular dipeptidase; able to hydrolyze a broad range of dipeptides but no tri-, tetra-, or larger oligopeptides; differences in the amino acid specificity of the cleavage site varies between species; similar to succinyl-diaminopimelate desuccinylases YP_002996906.1 similar to NAD(P)H-dependent quinone reductase [Streptococcus pyogenes MGAS6180] YP_002996907.1 similar to pyruvate oxidase or other thiamine pyrophosphate-requiring enzyme [Lactobacillus casei ATCC 334] YP_002996908.1 probable ORF of N-terminal portion of pyruvate oxidase [Lactobacillus paracasei] resulted from mutation by unknown reason YP_002996909.1 probable ORF of C-terminal portion of pyruvate oxidase [Lactobacillus paracasei] resulted from mutation by unknown reason YP_002996910.1 The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision YP_002996911.1 similar to phosphatase YbjI [Escherichia coli HS] YP_002996912.1 similar to succinate-semialdehyde dehydrogenase [NADP+] [Streptococcus pyogenes MGAS10394] YP_002996913.1 similar to hydrolase HAD superfamily [Streptococcus pyogenes MGAS5005] YP_002996914.1 similar to hypothetical protein RUMTOR 00521 [Ruminococcus torques ATCC 27756] YP_002996915.1 similar to permease [Campylobacter hominis ATCC BAA-381] YP_002996916.1 similar to hypothetical protein CLORAM 03030 [Clostridium ramosum DSM 1402] YP_002996917.1 similar to hypothetical protein SGO 0826 [Streptococcus gordonii str. Challis substr. CH1] YP_002996918.1 similar to iron(III)-binding protein [Streptococcus pyogenes MGAS6180] YP_002996919.1 similar to two-component response regulator YesN [Streptococcus pyogenes MGAS10394] YP_002996920.1 similar to two-component sensor kinase YesM [Streptococcus pyogenes MGAS10394] YP_002996921.1 similar to PTS system mannose/fructose family IID component [Streptococcus pyogenes MGAS6180] YP_002996922.1 similar to PTS system mannose/fructose family IIC component [Streptococcus pyogenes MGAS2096] YP_002996923.1 similar to PTS system mannose/fructose family IIB component [Streptococcus pyogenes MGAS10750] YP_002996924.1 similar to PTS system mannose/fructose family IIA component [Streptococcus pyogenes MGAS2096] YP_002996925.1 similar to hypothetical membrane spanning protein [Streptococcus pyogenes MGAS10394] YP_002996926.1 similar to hypothetical protein STRINF 01596 [Streptococcus infantarius subsp. infantarius ATCC BAA-102] YP_002996927.1 similar to SpiA (OrfY protein) ( sakacin P immunity protein) [Lactobacillus casei BL23] YP_002996928.1 similar to hypothetical protein STRINF 01005 [Streptococcus infantarius subsp. infantarius ATCC BAA-102] YP_002996929.1 similar to hypothetical protein STRINF 01223 [Streptococcus infantarius subsp. infantarius ATCC BAA-102] YP_002996930.1 this stereospecific enzymes reduces the R isomer of methionine sulfoxide while MsrA reduces the S form; provides protection against oxidative stress YP_002996931.1 binds to the ribosome on the universally-conserved alpha-sarcin loop YP_002996932.1 catalyzes the formation of nucleoside triphosphate from ATP and nucleoside diphosphate YP_002996933.1 similar to hypothetical protein SAM 0929 [Streptococcus agalactiae CJB111] YP_002996934.1 similar to hypothetical protein SAM 0929 [Streptococcus agalactiae CJB111] YP_002996935.1 similar to conserved hypothetical protein [Streptococcus agalactiae 18RS21] YP_002996936.1 similar to conserved hypothetical protein [Streptococcus agalactiae H36B] YP_002996937.1 similar to hypothetical protein MGAS2096 Spy0846 [Streptococcus pyogenes MGAS2096] YP_002996938.1 similar to hypothetical protein SPs1174 [Streptococcus pyogenes SSI-1] YP_002996939.1 similar to hypothetical cytosolic protein [Streptococcus pyogenes MGAS5005] YP_002996940.1 similar to hypothetical cytosolic protein [Streptococcus pyogenes MGAS10750] YP_002996941.1 similar to hypothetical protein MGAS9429 Spy0884 [Streptococcus pyogenes MGAS9429] YP_002996942.1 similar to hypothetical membrane spanning protein [Streptococcus pyogenes MGAS10270] YP_002996943.1 similar to haloacid dehalogenase-like hydrolase [Streptococcus pyogenes MGAS2096] YP_002996944.1 similar to acyl-acyl carrier protein thioesterase [Streptococcus pyogenes MGAS5005] YP_002996945.1 catalyzes the oxygen-independent formation of protoporphyrinogen-IX from coproporphyrinogen-III YP_002996946.1 similar to hypothetical protein SpyM50995 [Streptococcus pyogenes str. Manfredo] YP_002996947.1 catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate YP_002996948.1 similar to hypothetical membrane associated protein [Streptococcus pyogenes MGAS6180] YP_002996949.1 similar to hypothetical protein SpyM50998 [Streptococcus pyogenes str. Manfredo] YP_002996950.1 similar to UDP-N-acetylmuramoylalanyl-D-glutamate- 2,6-diaminopimelate ligase [Streptococcus pyogenes MGAS10270] YP_002996951.1 similar to CobB/CobQ-like glutamine amidotransferase domain [Streptococcus pyogenes MGAS2096] YP_002996952.1 similar to lipoate-protein ligase [Streptococcus pyogenes M1 GAS] YP_002996953.1 similar to hypothetical membrane associated protein [Streptococcus equi subsp. zooepidemicus MGCS10565] YP_002996954.1 similar to transcriptional regulator PadR family [Streptococcus pyogenes MGAS10394] YP_002996955.1 similar to dihydrolipoamide dehydrogenase [Streptococcus pyogenes MGAS10394] YP_002996956.1 similar to hypothetical protein MGAS2096 Spy0827 [Streptococcus pyogenes MGAS2096] YP_002996957.1 similar to dihydrolipoamide acetyltransferase [Streptococcus pyogenes MGAS10394] YP_002996958.1 similar to pyruvate dehydrogenase E1 component beta subunit [Streptococcus pyogenes MGAS10394] YP_002996959.1 similar to pyruvate dehydrogenase E1 component alpha subunit [Streptococcus pyogenes MGAS10394] YP_002996960.1 similar to ABC transporter ATP-binding protein [Streptococcus pyogenes MGAS5005] YP_002996961.1 similar to hypothetical protein SpyoM01000868 [Streptococcus pyogenes M49 591] YP_002996962.1 similar to acetyl esterase [Streptococcus pyogenes MGAS6180] YP_002996963.1 similar to Zn-dependent hydrolase [Streptococcus pyogenes MGAS10394] YP_002996964.1 similar to ABC transporter ATP-binding protein [Streptococcus pyogenes MGAS10394] YP_002996965.1 similar to ABC transporter permease protein [Streptococcus pyogenes str. Manfredo] YP_002996966.1 similar to ABC transporter substrate-binding protein [Streptococcus pyogenes MGAS10394] YP_002996967.1 similar to hypothetical protein gbs1118 [Streptococcus agalactiae NEM316] YP_002996968.1 Class B; non-specific; catalyzes the dephosphorylation of organic phosphomonoesters; also has phosphotransferase activity YP_002996969.1 similar to hypothetical protein SAG0634 [Streptococcus agalactiae 2603V/R] YP_002996970.1 similar to ISSag4 transposase orfA [Streptococcus agalactiae A909] YP_002996971.1 similar to hypothetical protein gbs1153 [Streptococcus agalactiae NEM316] YP_002996972.1 similar to fibronectin-binding protein [Streptococcus pyogenes MGAS10270] YP_002996973.1 similar to tetratricopeptide repeat family protein [Streptococcus pyogenes MGAS10394] YP_002996974.1 similar to hypothetical membrane spanning protein [Streptococcus pyogenes MGAS5005] YP_002996975.1 similar to 7,8-dihydro-8-oxoguanine-triphosphatase [Streptococcus pyogenes MGAS10750] YP_002996976.1 similar to hypothetical protein STER 0685 [Streptococcus thermophilus LMD-9] YP_002996977.1 similar to hypothetical protein CLORAM 02318 [Clostridium ramosum DSM 1402] YP_002996978.1 similar to dTDP-glucose 4,6-dehydratase [Streptococcus pyogenes MGAS10394] YP_002996979.1 similar to dTDP-4-dehydrorhamnose 3,5-epimerase [Streptococcus pyogenes MGAS6180] YP_002996980.1 similar to glucose-1-phosphate thymidyl transferase [Streptococcus pyogenes str. Manfredo] YP_002996981.1 similar to glycine/D-amino acid oxidases family [Streptococcus pyogenes MGAS10750] YP_002996982.1 similar to hypothetical protein STRINF 01350 [Streptococcus infantarius subsp. infantarius ATCC BAA-102] YP_002996983.1 similar to NIF3 (NGG1p interacting factor 3) family protein [Streptococcus pyogenes str. Manfredo] YP_002996984.1 similar to hypothetical cytosolic protein [Streptococcus pyogenes MGAS2096] YP_002996985.1 similar to endonuclease III [Streptococcus pyogenes MGAS5005] YP_002996986.1 similar to DNA replication protein [Streptococcus pyogenes MGAS10394] YP_002996987.1 catalyzes a salvage reaction resulting in the formation of AMP which is metabolically less costly than a de novo synthesis YP_002996988.1 similar to single-stranded-DNA-specific exonuclease [Streptococcus pyogenes MGAS5005] YP_002996989.1 similar to short chain dehydrogenase [Streptococcus pyogenes MGAS10394] YP_002996990.1 member of metallo-beta-lactamase family; the purified enzyme from Escherichia coli forms dimeric zinc phosphodiesterase; in Bacillus subtilis this protein is a 3'-tRNA processing endoribonuclease and is essential while in Escherichia coli it is not; associates with two zinc ions YP_002996991.1 similar to hypothetical protein spyM18 0980 [Streptococcus pyogenes MGAS8232] YP_002996992.1 similar to HflX [Streptococcus pyogenes MGAS10394] YP_002996993.1 IPP transferase; isopentenyltransferase; involved in tRNA modification; in Escherichia coli this enzyme catalyzes the addition of a delta2-isopentenyl group from dimethylallyl diphosphate to the N6-nitrogen of adenosine adjacent to the anticodon of tRNA species that read codons starting with uracil; further tRNA modifications may occur; mutations in miaA result in defects in translation efficiency and fidelity YP_002996994.1 similar to hypothetical protein M6 Spy0747 [Streptococcus pyogenes MGAS10394] YP_002996995.1 similar to exfoliative toxin [Streptococcus pyogenes MGAS10394] YP_002996996.1 similar to glutathione S-transferase [Streptococcus pyogenes MGAS10750] YP_002996997.1 similar to hypothetical protein Sez 1253 [Streptococcus equi subsp. zooepidemicus MGCS10565] YP_002996998.1 similar to hypothetical protein SpyM51090 [Streptococcus pyogenes str. Manfredo] YP_002996999.1 similar to hypothetical protein Spy49 0725c [Streptococcus pyogenes NZ131] YP_002997000.1 similar to NADPH-dependent FMN reductase [Bacillus coagulans 36D1] YP_002997001.1 similar to glycogen phosphorylase [Streptococcus pyogenes MGAS10394] YP_002997002.1 amylomaltase; acts to release glucose from maltodextrins YP_002997003.1 similar to maltose operon transcriptional repressor MalR [Streptococcus equi subsp. zooepidemicus MGCS10565] YP_002997004.1 similar to transposase [Streptococcus pyogenes MGAS10270] YP_002997005.1 similar to maltose/maltodextrin-binding protein [Streptococcus pyogenes MGAS10750] YP_002997006.1 similar to maltose/maltodextrin ABC transport system (permease) [Streptococcus pyogenes M1 GAS] YP_002997007.1 similar to MalG [Streptococcus pyogenes MGAS10394] YP_002997008.1 similar to transcriptional regulator, LacI family [Streptococcus pyogenes MGAS10270] YP_002997009.1 similar to maltodextrose utilization protein malA [Streptococcus pyogenes MGAS10270] YP_002997010.1 similar to maltodextrin transport system permease protein malD [Streptococcus pyogenes MGAS10270] YP_002997011.1 similar to maltose transport system permease protein [Streptococcus pyogenes MGAS5005] YP_002997012.1 similar to maltodextrin transport system permease protein malC [Streptococcus pyogenes MGAS10270] YP_002997013.1 similar to neopullulanase/cyclomaltodextrinase/ maltogenic alpha-amylase [Streptococcus pyogenes MGAS5005] YP_002997014.1 similar to maltose/maltodextrin-binding protein [Streptococcus pyogenes MGAS6180] YP_002997015.1 similar to secreted protein DltD [Streptococcus pyogenes MGAS315] YP_002997016.1 D-alanyl carrier protein subunit; involved in the incorporation of D-alanine into membrane-associated D-alanyl-lipoteichoic acid; D-alanyl carrier protein is the acceptor of activated D-alanine which it donates to a membrane acceptor(D-alanyl transferase) for incorporation into membrane lipoteichoic acid YP_002997017.1 similar to DltB [Streptococcus pyogenes MGAS10394] YP_002997018.1 transfers D-alanine to the D-alanyl carrier protein during the incorporation of D-alanine into lipoteichoic acid YP_002997019.1 similar to hypothetical protein spyM18 1325 [Streptococcus pyogenes MGAS8232] YP_002997020.1 The UvrABC repair system catalyzes the recognition and processing of DNA lesions. The beta-hairpin of the Uvr-B subunit is inserted between the strands, where it probes for the presence of a lesion YP_002997021.1 similar to glutamine-binding protein/glutamine transport system permease protein glnP [Streptococcus pyogenes MGAS10270] YP_002997022.1 similar to glutamine transport ATP-binding protein [Streptococcus pyogenes MGAS5005] YP_002997023.1 similar to nicotinamide mononucleotide transporter [Streptococcus pyogenes MGAS6180] YP_002997024.1 essential GTPase; exhibits high exchange rate for GTP/GDP; associates with 50S ribosomal subunit; involved in regulation of chromosomal replication YP_002997025.1 similar to hypothetical protein MGAS2096 Spy1090 [Streptococcus pyogenes MGAS2096] YP_002997026.1 similar to aminopeptidase PepS [Streptococcus equi subsp. zooepidemicus MGCS10565] YP_002997027.1 similar to hypothetical protein ANACAC 02747 [anaerostipes caccae DSM 14662] YP_002997028.1 similar to ribosomal small subunit pseudouridine synthase A [Streptococcus pyogenes MGAS5005] YP_002997029.1 similar to hypothetical protein MGAS10750 Spy1192 [Streptococcus pyogenes MGAS10750] YP_002997030.1 similar to transporter MFS superfamily [Streptococcus pyogenes MGAS5005] YP_002997031.1 similar to hypothetical cytosolic protein [Streptococcus pyogenes MGAS5005] YP_002997032.1 similar to hypothetical protein SAG0689 [Streptococcus agalactiae 2603V/R] YP_002997033.1 similar to ABC transporter ATP-binding protein [Streptococcus agalactiae 2603V/R] YP_002997034.1 similar to thioesterase superfamily protein [Streptococcus pyogenes MGAS2096] YP_002997035.1 similar to uridine phosphorylase [Streptococcus thermophilus LMD-9] YP_002997036.1 similar to YaeC family protein [Streptococcus agalactiae 2603V/R] YP_002997037.1 similar to ISSdy1, transposase OrfA [Streptococcus agalactiae 515] YP_002997038.1 similar to ISSdy1, transposase OrfB [Streptococcus agalactiae 2603V/R] YP_002997039.1 similar to ATPase component of ABC transporters with duplicated ATPase domains [Streptococcus suis 98HAH33] YP_002997040.1 similar to ABC transporter ATP-binding protein [Streptococcus equi subsp. YP_002997041.1 similar to ABC transporter ATP-binding protein/peptidase [Treponema denticola ATCC 35405] YP_002997042.1 similar to hypothetical protein llmg 0328 [Lactococcus lactis subsp. cremoris MG1363] YP_002997043.1 similar to transcriptional regulator PlcR [Streptococcus pneumoniae SP3-BS71] YP_002997044.1 similar to relaxase [Streptococcus macedonicus] YP_002997045.1 similar to transposase [Streptococcus pyogenes MGAS6180] YP_002997046.1 similar to transposase [Streptococcus pyogenes MGAS10270] YP_002997047.1 similar to hypothetical protein PEPMIC 00594 [Peptostreptococcus micros ATCC 33270] YP_002997048.1 similar to hypothetical protein PEPMIC 00190 [Peptostreptococcus micros ATCC 33270] YP_002997049.1 similar to hypothetical protein EUBDOL 02334 [Eubacterium dolichum DSM 3991] YP_002997050.1 similar to hypothetical protein PEPMIC 00192 [Peptostreptococcus micros ATCC 33270] YP_002997051.1 similar to hypothetical protein PEPMIC 00193 [Peptostreptococcus micros ATCC 33270] YP_002997052.1 similar to hypothetical protein PEPMIC 00194 [Peptostreptococcus micros ATCC 33270] YP_002997053.1 similar to hypothetical protein TDE2175 [Treponema denticola ATCC 35405] YP_002997054.1 similar to site-specific recombinase [Treponema denticola ATCC 35405] YP_002997055.1 similar to hypothetical protein PEPMIC 00594 [Peptostreptococcus micros ATCC 33270] YP_002997056.1 similar to hypothetical protein PEPMIC 00593 [Peptostreptococcus micros ATCC 33270] YP_002997057.1 similar to hypothetical protein PEPMIC 00592 [Peptostreptococcus micros ATCC 33270] YP_002997058.1 similar to hypothetical protein PEPMIC 00591 [Peptostreptococcus micros ATCC 33270] YP_002997059.1 similar to hypothetical protein PEPMIC 00591 [Peptostreptococcus micros ATCC 33270] YP_002997060.1 similar to PBP 5 synthesis repressor [Streptococcus pyogenes MGAS8232] YP_002997061.1 catalyzes the formation of shikimate 3-phosphate from shikimate in aromatic amino acid biosynthesis YP_002997062.1 catalyzes the formation of 5-O-(1-carboxyvinyl)-3-phosphoshikimate from phosphoenolpyruvate and 3-phosphoshikimate in tryptophan biosynthesis YP_002997063.1 similar to ribonuclease BN [Streptococcus pyogenes MGAS10394] YP_002997064.1 catalyzes the removal of N-terminal amino acids from peptides and arylamides YP_002997065.1 similar to cytosolic protein containing multiple CBS domains [Streptococcus pyogenes MGAS10750] YP_002997066.1 similar to acetyltransferase GNAT family [Streptococcus equi subsp. zooepidemicus MGCS10565] YP_002997067.1 similar to immunoglobulin G-binding protein G precursor (IgG-binding protein G) YP_002997068.1 similar to glycosyl hydrolase family 3 [Streptococcus agalactiae 515] YP_002997069.1 similar to phosphoglycolate phosphatase [Streptococcus pyogenes MGAS10270] YP_002997070.1 Converts D-mannonate to D-mannuronate YP_002997071.1 catalyzes the formation of 2-dehydro-3-deoxy-D-gluconate from mannonate YP_002997072.1 catalyzes the interconversion of D-glucuronate to D-fructuronate or D-galacturonate to D-tagaturonate; functions in glucuronic and galacturonic metabolism YP_002997073.1 similar to uronate isomerase [Streptococcus pyogenes MGAS10270] YP_002997074.1 similar to 4-hydroxy-2-oxoglutarate aldolase / 2-dehydro-3-deoxyphosphogluconate aldolase [Streptococcus pyogenes MGAS10270] YP_002997075.1 similar to transcriptional regulator GntR family [Streptococcus pyogenes MGAS10270] YP_002997076.1 similar to beta-glucuronidase [Streptococcus pyogenes MGAS10270] YP_002997077.1 similar to 2-dehydro-3-deoxygluconokinase [Streptococcus pyogenes MGAS10270] YP_002997078.1 similar to sugar /sodium symporter [Streptococcus pyogenes MGAS10270] YP_002997079.1 adds enolpyruvyl to UDP-N-acetylglucosamine as a component of cell wall formation; gram-positive bacteria have 2 copies of MurA which are active YP_002997080.1 catalyzes the formation of S-adenosylmethionine from methionine and ATP; methionine adenosyltransferase YP_002997081.1 similar to internalin protein [Streptococcus pyogenes MGAS10394] YP_002997082.1 catalyzes the formation of biotinyl-5'-AMP, also acts as a transcriptional repressor of the biotin operon YP_002997083.1 similar to hypothetical protein M28 Spy1103 [Streptococcus pyogenes MGAS6180] YP_002997084.1 catalyzes the DNA-template-directed extension of the 3'-end of a DNA strand; the tau chain serves as a scaffold to help in the dimerizaton of the alpha,epsilon and theta core complex; the gamma chain seems to interact with the delta and delta' subunits to transfer the beta subunit on the DNA YP_002997085.1 similar to GAF domain-containing proteins [Streptococcus pyogenes MGAS6180] YP_002997086.1 similar to hypothetical protein SPy 1366 [Streptococcus pyogenes M1 GAS] YP_002997087.1 similar to hypothetical membrane spanning protein [Streptococcus pyogenes MGAS10394] YP_002997088.1 functions in pyrimidine salvage; pyrimidine ribonucleoside kinase; phosphorylates nucleosides or dinucleosides to make UMP or CMP using ATP or GTP as the donor YP_002997089.1 similar to ATP-dependent RNA helicase [Streptococcus pyogenes MGAS10394] YP_002997090.1 similar to transposase [Streptococcus pyogenes MGAS10750] YP_002997091.1 similar to transposase [Streptococcus pyogenes MGAS5005] YP_002997092.1 similar to transposase [Streptococcus pyogenes MGAS5005] YP_002997093.1 similar to haloacid dehalogenase-like hydrolase [Streptococcus suis 89/1591] YP_002997094.1 similar to hypothetical protein CLOBAR 01981 [Clostridium bartlettii DSM 16795] YP_002997095.1 required for arbutin uptake and metabolism YP_002997096.1 similar to phosphoglycerate mutase family protein [Streptococcus sanguinis SK36] YP_002997097.1 similar to hypothetical protein STRINF 01174 [Streptococcus infantarius subsp. infantarius ATCC BAA-102] YP_002997099.1 similar to hypothetical protein lwe2314 [Listeria welshimeri serovar 6b str. SLCC5334] YP_002997100.1 similar to hypothetical protein STRINF 01173 [Streptococcus infantarius subsp. infantarius ATCC BAA-102] YP_002997101.1 probable ORF of C-terminal portion of glycoside hydrolase, family 1 [Streptococcus suis 89/1591] resulted from mutation by unknown reason YP_002997102.1 probable ORF of N-terminal portion of glycoside hydrolase, family 1 [Streptococcus suis 89/1591] resulted from mutation by unknown reason YP_002997103.1 similar to acetyltransferase [Clostridium difficile ATCC 43255] YP_002997104.1 similar to haloacid dehalogenase-like hydrolase [Streptococcus gordonii str. Challis substr. CH1] YP_002997105.1 similar to hypothetical protein PEPE 0230 [Pediococcus pentosaceus ATCC 25745] YP_002997106.1 required for cellobiose uptake and metabolism YP_002997107.1 similar to conserved hypothetical protein [Bacillus coagulans 36D1] YP_002997108.1 required for cellobiose uptake and metabolism YP_002997109.1 similar to transcriptional antiterminator bglG [Streptococcus suis 89/1591] YP_002997110.1 required for cellobiose uptake and metabolism YP_002997111.1 similar to ISSdy1, transposase OrfB [Streptococcus agalactiae 2603V/R] YP_002997112.1 similar to ISSag4, transposase orfA [Streptococcus agalactiae A909] YP_002997113.1 similar to hypothetical protein SsuiDRAFT 1295 [Streptococcus suis 89/1591] YP_002997114.1 similar to IS1191 transposase [Streptococcus thermophilus LMG 18311] YP_002997115.1 similar to conserved hypothetical protein [Streptococcus suis 89/1591] YP_002997116.1 converts 6-phospho-beta-D-glucosyl-(1,4)-D-glucose to glucose and glucose 6-phosphate; required for cellobiose uptake and metabolism YP_002997117.1 similar to protein of unknown function/lipoprotein [Streptococcus agalactiae 2603V/R] YP_002997118.1 similar to phosphosugar-binding transcriptional regulator [Clostridium botulinum NCTC2916] YP_002997119.1 similar to hypothetical protein SMU.1108c [Streptococcus mutans UA159] YP_002997120.1 similar to oxidoreductase [Lactobacillus plantarum WCFS1] YP_002997121.1 similar to beta-glucosidase, [Streptococcus sanguinis SK36] YP_002997122.1 similar to hypothetical protein STRINF 01402 [Streptococcus infantarius subsp. infantarius ATCC BAA-102] YP_002997123.1 PTS system beta-glucoside-specific IIABC component [Streptococcus suis 89/1591]; similar to sugar-specific permease EIIA 1 domain YP_002997124.1 similar to hypothetical protein STRINF 01404 [Streptococcus infantarius subsp. infantarius ATCC BAA-102] YP_002997125.1 similar to permease ATP-binding protein [Streptococcus gordonii str. Challis substr. CH1] YP_002997126.1 similar to transposase IS861 orfB [Streptococcus equi subsp. zooepidemicus MGCS10565] YP_002997127.1 similar to polysaccharide deacetylase family protein [Streptococcus pyogenes NZ131] YP_002997128.1 similar to NADP-dependent glyceraldehyde-3-phosphate dehydrogenase [Streptococcus pyogenes MGAS5005] YP_002997129.1 similar to phosphoenolpyruvate-protein phosphotransferase [Streptococcus pyogenes MGAS5005] YP_002997130.1 similar to phosphocarrier protein HPr [Streptococcus pyogenes MGAS10394] YP_002997131.1 similar to glutaredoxin [Streptococcus pyogenes MGAS10394] YP_002997132.1 Catalyzes the rate-limiting step in dNTP synthesis YP_002997133.1 B2 or R2 protein; type 1b enzyme; catalyzes the rate-limiting step in dNTP synthesis; converts nucleotides to deoxynucleotides; forms a homodimer and then a multimeric complex with NrdE YP_002997134.1 similar to chloride channel protein [Streptococcus pyogenes MGAS10270] YP_002997135.1 similar to CAAX amino terminal protease family [Streptococcus pyogenes MGAS5005] YP_002997136.1 similar to hypothetical membrane spanning protein [Streptococcus pyogenes MGAS10394] YP_002997137.1 similar to transcriptional regulator Cro /CI family [Streptococcus pyogenes MGAS10394] YP_002997138.1 similar to probable surface antigen negative regulator Par [Streptococcus suis 98HAH33] YP_002997139.1 Catalyzes a two-step reaction, first charging an alanyl molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA YP_002997140.1 similar to hypothetical protein SAK 0933 [Streptococcus agalactiae A909] YP_002997141.1 cis/trans isomerase of peptidylprolyl; PPIase; membrane-bound lipoprotein YP_002997142.1 similar to methyltransferase [Streptococcus pyogenes SSI-1] YP_002997143.1 similar to oxalate formate antiporter [Streptococcus pyogenes SSI-1] YP_002997144.1 similar to hydrolase haloacid dehalogenase-like family [Streptococcus equi subsp. zooepidemicus MGCS10565] YP_002997145.1 similar to acetyltransferase GNAT family [Streptococcus equi subsp. zooepidemicus MGCS10565] YP_002997146.1 similar to NADPH-dependent FMN reductase [Bacillus coagulans 36D1] YP_002997147.1 similar to oligoendopeptidase F [Streptococcus pyogenes MGAS5005] YP_002997148.1 similar to competence protein/transcription factor [Streptococcus pyogenes MGAS10394] YP_002997149.1 probable ORF of C-terminal portion of major facilitator family protein [Streptococcus agalactiae 2603V/R] resulted from mutation by unknown reason YP_002997150.1 probable ORF of N-terminal portion of major facilitator family protein [Streptococcus agalactiae 2603V/R] resulted from mutation by unknown reason YP_002997151.1 similar to 16S pseudouridylate synthetase [Streptococcus pyogenes MGAS8232] YP_002997152.1 similar to glucosamine-6-phosphate isomerase [Streptococcus pyogenes MGAS10394] YP_002997153.1 Synthesizes oQ from preQ1 in a single S-adenosylmethionine-requiring step YP_002997154.1 similar to hypothetical cytosolic protein [Streptococcus pyogenes MGAS10750] YP_002997155.1 similar to hypothetical protein SSA 0722 [Streptococcus sanguinis SK36] YP_002997156.1 similar to superoxide dismutase [Streptococcus pyogenes MGAS6180] YP_002997157.1 required for the assembly and function of the DNAX complex which is required for the assembly of the beta subunit onto primed DNA YP_002997158.1 similar to competence protein [Streptococcus pyogenes str. Manfredo] YP_002997159.1 similar to competence protein [Streptococcus pyogenes str. Manfredo] YP_002997160.1 similar to 1-acyl-sn-glycerol-3-phosphate acyltransferase [Streptococcus pyogenes MGAS10270] YP_002997161.1 similar to methyltransferase [Streptococcus pyogenes MGAS6180] YP_002997162.1 similar to hypothetical protein with endo/excinuclease domain [Streptococcus pyogenes MGAS10394] YP_002997163.1 similar to Kup system potassium uptake protein [Streptococcus pyogenes MGAS10394] YP_002997164.1 similar to ATP-dependent RNA helicase [Streptococcus pyogenes MGAS5005] YP_002997165.1 similar to YaeC family protein [Streptococcus agalactiae 2603V/R] YP_002997166.1 similar to ABC transporter permease protein [Streptococcus agalactiae 2603V /R] YP_002997167.1 similar to ABC transporter ATP-binding protein [Streptococcus agalactiae 2603V/R] YP_002997168.1 similar to superfamily I DNA and RNA helicase [Streptococcus suis 98HAH33] YP_002997169.1 stimulates the release of release factors 1 and 2 from the ribosome after hydrolysis of the ester bond in peptidyl-tRNA has occurred; GDP/GTP-binding protein YP_002997170.1 similar to hypothetical membrane spanning protein [Streptococcus pyogenes MGAS5005] YP_002997171.1 similar to D-Ala-D-Ala adding enzyme [Streptococcus pyogenes MGAS315] YP_002997172.1 similar to D-alanylalanine synthetase [Streptococcus pyogenes M1 GAS] YP_002997173.1 involved in a recombinational process of DNA repair, independent of the recBC complex YP_002997174.1 similar to cell division protein FtsI [Streptococcus equi subsp. zooepidemicus MGCS10565] YP_002997175.1 similar to formate transporter [Streptococcus pyogenes MGAS10270] YP_002997176.1 similar to hypothetical protein SPy 1425 [Streptococcus pyogenes M1 GAS] YP_002997177.1 similar to transcriptional regulator [Streptococcus pyogenes M1 GAS] YP_002997178.1 2,3-bisphosphoglycerate-dependent; catalyzes the interconversion of 2-phosphoglycerate to 3-phosphoglycerate YP_002997179.1 similar to transposase [Streptococcus pyogenes MGAS10270] YP_002997180.1 catalyzes the conversion of dihydroorotate to orotate in the pyrimidine biosynthesis pathway; subclass 1A is a dimer formed by two identical PyrD subunits each containing an FMN group YP_002997181.1 similar to hypothetical protein M6 Spy1192 [Streptococcus pyogenes MGAS10394] YP_002997182.1 similar to heavy metal-transporting ATPase [Streptococcus pyogenes M1 GAS] YP_002997183.1 similar to positive transcriptional regulator MutR family [Streptococcus equi subsp. zooepidemicus MGCS10565] YP_002997184.1 similar to transporter probable SP1116 [Streptococcus gordonii str. Challis substr. CH1] YP_002997185.1 similar to DNA-binding protein HU [Streptococcus pyogenes MGAS10394] YP_002997186.1 similar to hypothetical protein SPy 1491 [Streptococcus pyogenes M1 GAS] YP_002997187.1 similar to Lipase /Acylhydrolase with GDSL-like motif [Streptococcus pyogenes MGAS10750] YP_002997188.1 similar to DegV family protein [Streptococcus pyogenes MGAS10394] YP_002997189.1 similar to hypothetical protein M28 Spy1166 [Streptococcus pyogenes MGAS6180] YP_002997190.1 similar to RecN [Streptococcus pyogenes MGAS10394] YP_002997191.1 similar to arginine repressor argR [Streptococcus pyogenes MGAS10750] YP_002997192.1 similar to hemolysin [Streptococcus pyogenes MGAS5005] YP_002997193.1 similar to dimethylallyltransferase/ geranyltranstransferase [Streptococcus pyogenes MGAS5005]; trans-Isoprenyl Diphosphate Synthases (trans IPPS)head-to-tail (HT) (1'-4) condensation reactions; cd00685 YP_002997194.1 catalyzes the bidirectional exonucleolytic cleavage of DNA YP_002997195.1 bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides YP_002997196.1 similar to sugar kinase [Streptococcus equi subsp. zooepidemicus MGCS10565] YP_002997197.1 catalyzes the formation of 5,10-methenyltetrahydrofolate from 5,10-methylenetetrahydrofolate and subsequent formation of 10-formyltetrahydrofolate from 5,10-methenyltetrahydrofolate YP_002997198.1 similar to phosphoglucomutase [Streptococcus pyogenes MGAS5005] YP_002997199.1 similar to deoxyribodipyrimidine photolyase [Streptococcus pyogenes MGAS5005] YP_002997200.1 similar to hypothetical protein SMU.571 [Streptococcus mutans UA159] YP_002997201.1 similar to ferrous ion transport protein B [Streptococcus mutans UA159] YP_002997202.1 similar to ferrous ion transport protein A [Streptococcus mutans UA159] YP_002997203.1 similar to amino acid transport ATP-binding protein [Streptococcus pyogenes MGAS10394] YP_002997204.1 similar to arginine transport system permease protein [Streptococcus pyogenes MGAS5005] YP_002997205.1 similar to ATP-dependent endopeptidase clp ATP-binding subunit clpE [Streptococcus pyogenes MGAS2096] YP_002997206.1 7,8-dihydro-8-oxoguanine-triphosphatase; similar to mutator protein (78-dihydro-8-oxoguanine-triphosphatase) [Streptococcus pyogenes MGAS6180] YP_002997207.1 similar to hypothetical cytosolic protein [Streptococcus pyogenes MGAS10394] YP_002997208.1 IleRS; catalyzes the formation of isoleucyl-tRNA(Ile) from isoleucine and tRNA(Ile); since isoleucine and other amino acids such as valine are similar, there are additional editing function in this enzyme; one is involved in hydrolysis of activated valine-AMP and the other is involved in deacylation of mischarged Val-tRNA(Ile); there are two active sites, one for aminoacylation and one for editing; class-I aminoacyl-tRNA synthetase family; some organisms carry two different copies of this enzyme YP_002997209.1 similar to cell division initiation protein DivIVA [Streptococcus pyogenes MGAS6180] YP_002997210.1 similar to hypothetical protein SpyM50607 [Streptococcus pyogenes str. Manfredo] YP_002997211.1 similar to hypothetical protein SpyM50606 [Streptococcus pyogenes str. Manfredo] YP_002997212.1 similar to hypothetical cytosolic protein [Streptococcus pyogenes MGAS10750] YP_002997213.1 similar to pyridoxaL 5'-phosphate dependent enzyme class III family [Streptococcus equi subsp. zooepidemicus MGCS10565] YP_002997214.1 GTPase; similar structure to tubulin; forms ring-shaped polymers at the site of cell division; other proteins such as FtsA, ZipA, and ZapA, interact with and regulate FtsZ function YP_002997215.1 similar to cell division protein [Streptococcus pyogenes MGAS5005] YP_002997216.1 probable ORF of C-terminal portion of cell division protein [Streptococcus pyogenes MGAS8232] resulted from mutation by unknown reason YP_002997217.1 probable ORF of N-terminal portion of cell division protein [Streptococcus pyogenes MGAS8232] resulted from mutation by unknown reason YP_002997218.1 UDP-N-acetylglucosamine--N-acetylmuramyl- (pentapeptide) pyrophosphoryl-undecaprenol N-acetylglucosamine transferase; involved in cell wall formation; inner membrane-associated; last step of peptidoglycan synthesis YP_002997219.1 UDP-N-acetylmuramoylalanine--D-glutamate ligase; involved in peptidoglycan biosynthesis; cytoplasmic; catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine during cell wall formation YP_002997220.1 similar to hypothetical protein [Streptococcus suis] YP_002997221.1 similar to hypothetical protein Sez 0590 [Streptococcus equi subsp. zooepidemicus MGCS10565] YP_002997222.1 similar to GTP-binding protein [Streptococcus pyogenes MGAS5005] YP_002997223.1 similar to rhodanese-related sulfurtransferase [Streptococcus pyogenes MGAS5005] YP_002997224.1 similar to glucokinase/xylose repressor [Streptococcus pyogenes MGAS5005] YP_002997225.1 similar to hypothetical cytosolic protein [Streptococcus pyogenes MGAS10394] YP_002997226.1 similar to ferroxidase [Streptococcus pyogenes MGAS10394] YP_002997227.1 similar to prepilin peptidase family [Streptococcus pyogenes MGAS6180] YP_002997228.1 similar to TCS response regulator [Streptococcus equi subsp. zooepidemicus MGCS10565] YP_002997229.1 similar to TCS sensor histidine kinase [Streptococcus equi subsp. zooepidemicus MGCS10565] YP_002997230.1 similar to ABC transporter permease protein [Streptococcus equi subsp. zooepidemicus MGCS10565] YP_002997231.1 similar to multi drug transpot ATP-binding protein [Streptococcus equi subsp. YP_002997232.1 similar to hypothetical protein gbs0508 [Streptococcus agalactiae NEM316] YP_002997233.1 similar to ABC transporter ATP-binding/permease protein [Streptococcus pneumoniae D39] YP_002997234.1 similar to ABC transporter ATP-binding/permease protein [Streptococcus agalactiae A909] YP_002997235.1 similar to VanZF domain protein [Streptococcus agalactiae COH1] YP_002997236.1 23S rRNA m2A2503 methyltransferase; methylates the C2 position of the A2530 nucleotide in 23S rRNA; may be involved in antibiotic resistance YP_002997237.1 similar to transcriptional regulator [Streptococcus pyogenes MGAS5005] YP_002997238.1 probable ORF of C-terminal portion of hypothetical protein SMU.796 [Streptococcus mutans UA159] resulted from mutation by unknown reason YP_002997239.1 probable ORF of N-terminal portion of hypothetical protein SMU.796 [Streptococcus mutans UA159] resulted from mutation by unknown reason YP_002997240.1 similar to hypothetical protein CLONEX 04238 [Clostridium nexile DSM 1787] YP_002997241.1 similar to transposase [Streptococcus pneumoniae SP9-BS68] YP_002997242.1 similar to D-ribose-binding protein precursor RbsB [Streptococcus equi subsp. YP_002997243.1 similar to ribose transport ATP-binding protein RbsA [Streptococcus equi subsp. zooepidemicus MGCS10565] YP_002997244.1 cytoplasmic mutarotase that catalyzes the conversion between beta-pyran and beta-furan forms of D-ribose; RbsD is required for efficient ribose utilization in E. coli; rbsD-mutant E. coli strains are unable to use ribose as a sole carbon source YP_002997245.1 similar to ribokinase RbsK [Streptococcus equi subsp. zooepidemicus MGCS10565] YP_002997246.1 similar to ribose transport operon repressor [Streptococcus pyogenes MGAS315] YP_002997247.1 similar to ATP-dependent endopeptidase Lon [Streptococcus pyogenes MGAS10270] YP_002997248.1 Catalyzes the conversion of ATP and pantetheine 4'-phosphate to diphosphate and 3'-dephospho-coA YP_002997249.1 similar to type II DNA modification methyltransferase [Streptococcus pyogenes MGAS315] YP_002997250.1 catalyzes the formation of asparagine from aspartate and ammonia YP_002997251.1 catalyzes the reversible synthesis of carbamate and ATP from carbamoyl phosphate and ADP YP_002997252.1 similar to transposase [Streptococcus pneumoniae SP9-BS68] YP_002997253.1 similar to hypothetical protein M5005 Spy 1271 [Streptococcus pyogenes MGAS5005] YP_002997254.1 similar to arginine/ornithine antiporter [Streptococcus pyogenes MGAS5005] YP_002997255.1 catalyzes the formation of ornithine and carbamylphosphate from citrulline in the arginine catabolic pathway YP_002997256.1 similar to COG0454, Histone acetyltransferase HPA2 and related acetyltransferases [Streptococcus pyogenes M49 591] YP_002997257.1 catalyzes the degradation of arginine to citruline and ammonia YP_002997258.1 similar to transcription regulator crp family [Streptococcus pyogenes MGAS10394] YP_002997259.1 similar to arginine repressor argR [Streptococcus pyogenes MGAS10394] YP_002997260.1 similar to hypothetical protein M28 Spy1216 [Streptococcus pyogenes MGAS6180] YP_002997261.1 similar to hypothetical cytosolic protein [Streptococcus pyogenes MGAS5005] YP_002997262.1 similar to two-component sensor kinase [Streptococcus pyogenes MGAS5005] YP_002997263.1 similar to two-component response regulator YesN [Streptococcus pyogenes MGAS10394] YP_002997264.1 similar to bifunctional methionine sulfoxide reductase A/B protein [Streptococcus pyogenes MGAS6180] YP_002997265.1 similar to thiol:disulfide interchange protein [Streptococcus pyogenes MGAS5005] YP_002997266.1 similar to cytochrome c-type biogenesis protein [Streptococcus pyogenes str. Manfredo] YP_002997267.1 similar to magnesium and cobalt transport protein [Streptococcus pyogenes MGAS10394] YP_002997268.1 similar to oxidoreductase [Streptococcus pyogenes str. Manfredo] YP_002997269.1 similar to hypothetical protein M6 Spy1308 [Streptococcus pyogenes MGAS10394] YP_002997270.1 similar to hypothetical protein SpyM50565 [Streptococcus pyogenes str. Manfredo] YP_002997271.1 valine--tRNA ligase; ValRS; converts valine ATP and tRNA(Val) to AMP PPi and valyl-tRNA(Val); class-I aminoacyl-tRNA synthetase type 1 subfamily; has a posttransfer editing process to hydrolyze mischarged Thr-tRNA(Val) which is done by the editing domain YP_002997272.1 similar to hypothetical protein M6 Spy1311 [Streptococcus pyogenes MGAS10394] YP_002997273.1 similar to acetyltransferase GNAT family [Streptococcus agalactiae 2603V/R] YP_002997274.1 similar to glyoxalase/bleomycin resistance protein/dioxygenase [Streptococcus suis 89/1591] YP_002997275.1 similar to hypothetical protein SPy 1571 [Streptococcus pyogenes M1 GAS] YP_002997276.1 similar to hypothetical protein M6 Spy1314 [Streptococcus pyogenes MGAS10394] YP_002997277.1 similar to hypothetical protein CLOBAR 02811 [Clostridium bartlettii DSM 16795] YP_002997278.1 similar to MOP/MATE family multidrug-resistance efflux pump NorM [Fusobacterium nucleatum subsp. polymorphum ATCC 10953] YP_002997279.1 catalyzes the formation of 3-deoxy-D-arabino-hept-2-ulosonate 7-phosphate from phosphoenolpyruvate and D-erythrose 4-phosphate YP_002997280.1 catalyzes the formation of 3-dehydroquinate from 3-deoxy-arabino-heptulonate 7-phosphate; functions in aromatic amino acid biosynthesis YP_002997281.1 similar to adhesion protein [Streptococcus uberis] YP_002997282.1 similar to hypothetical protein LSL 1395 [Lactobacillus salivarius UCC118] YP_002997283.1 similar to predicted permease [Streptococcus suis 05ZYH33] YP_002997284.1 similar to shikimate 5-dehydrogenase [Streptococcus pyogenes M1 GAS] YP_002997285.1 similar to beta-galactosidase [Streptococcus pyogenes MGAS2096] YP_002997286.1 similar to two-component response regulator [Streptococcus pyogenes MGAS6180] YP_002997287.1 similar to two-component sensor kinase [Streptococcus pyogenes MGAS6180] YP_002997288.1 similar to hypothetical membrane spanning protein [Streptococcus pyogenes MGAS10394] YP_002997289.1 similar to sugar-binding protein [Streptococcus pyogenes MGAS10750] YP_002997290.1 similar to binding-protein-dependent transport system membrane protein [Streptococcus pyogenes str. Manfredo] YP_002997291.1 similar to sugar transport system permease protein [Streptococcus pyogenes MGAS10270] YP_002997292.1 similar to glucokinase [Streptococcus pyogenes MGAS10394] YP_002997293.1 similar to alpha-1,2-mannosidase [Geobacillus sp. Y412MC10] YP_002997294.1 similar to two-component response regulator histidine kinase [Streptococcus pyogenes MGAS315] YP_002997295.1 similar tobeta-glucosidase [Streptococcus pyogenes MGAS5005] YP_002997296.1 similar to hyaluronoglucosaminidase [Streptococcus pyogenes MGAS10394] YP_002997297.1 similar to transcriptional regulator GntR family [Streptococcus pyogenes MGAS5005] YP_002997298.1 similar tohypothetical protein M28 Spy1357 [Streptococcus pyogenes MGAS6180] YP_002997299.1 similar toalpha-mannosidase [Streptococcus pyogenes MGAS5005] YP_002997300.1 similar to histone acetyltransferase HPA2 [Streptococcus sanguinis SK36] YP_002997301.1 similar to phosphinothricin N-acetyltransferase [Streptococcus equi subsp. zooepidemicus MGCS10565] YP_002997302.1 similar to hypothetical protein spyM18 1170 [Streptococcus pyogenes MGAS8232] YP_002997303.1 similar to AMP-dependent synthetase and ligase [Rhodopseudomonas palustris BisA53] YP_002997304.1 similar to hypothetical protein CLOHIR 01137 [Clostridium hiranonis DSM 13275] YP_002997305.1 similar to acyl-CoA acetyltransferase FadA [Carnobacterium sp. AT7] YP_002997306.1 similar to fatty oxidation complex protein [Staphylococcus saprophyticus subsp. saprophyticus ATCC 15305] YP_002997307.1 similar to hypothetical protein SSU98 0605 [Streptococcus suis 98HAH33] YP_002997308.1 similar to transposase IS4 [Streptococcus suis 89/1591] YP_002997309.1 no hit YP_002997310.1 similar to ABC transporter ATP-binding protein [Listeria monocytogenes str. 4b F2365] YP_002997311.1 similar to hypothetical protein PEPMIC 00589 [Peptostreptococcus micros ATCC 33270] YP_002997312.1 similar to RNA methyltransferase [Streptococcus pyogenes M1 GAS] YP_002997313.1 similar to unknown phage protein [Streptococcus pyogenes MGAS10394] YP_002997314.1 similar to protein gp30 [bacteriophage A118] [Listeria monocytogenes EGD-e] YP_002997315.1 similar to hypothetical protein PEPE 1706 [Pediococcus pentosaceus ATCC 25745] YP_002997316.1 similar to hypothetical protein phiPH15 gp59 [Streptococcus phage PH15] YP_002997317.1 similar to prophage LambdaSa2 lysin [Streptococcus agalactiae 2603V/R] YP_002997318.1 similar to N-acetylmuramoyl-L-alanine amidase [Streptococcus pyogenes MGAS5005] YP_002997319.1 similar to phage protein [bacteriophage 10750.2] YP_002997320.1 similar to phage protein [Streptococcus pyogenes MGAS5005] YP_002997321.1 similar to hypothetical protein SpyM3 1309 [Streptococcus pyogenes MGAS315] YP_002997322.1 similar to prophage LambdaSa1 minor structural protein [Streptococcus agalactiae 18RS21] YP_002997323.1 similar to phage protein [Streptococcus pyogenes MGAS5005] YP_002997324.1 similar to phage tail protein [bacteriophage 10750.2] YP_002997325.1 similar to platlet-binding protein minor tail fiber protein - phage associated [Streptococcus pyogenes MGAS315] YP_002997326.1 similar to endodeoxyribonuclease [Lactococcus phage r1t] YP_002997327.1 similar to phage protein [bacteriophage 10750.2] YP_002997328.1 similar to phage protein [Streptococcus pyogenes MGAS5005] YP_002997329.1 similar to phage protein [Streptococcus pyogenes MGAS5005] YP_002997330.1 similar to antigen A [Streptococcus pyogenes MGAS5005] YP_002997331.1 similar to antigen B [Streptococcus pyogenes MGAS5005] YP_002997332.1 similar to antigen C [bacteriophage 10750.2] YP_002997333.1 similar to phage protein [bacteriophage 10750.2] YP_002997334.1 similar to hypothetical protein SpyM3 1320 [Streptococcus pyogenes MGAS315] YP_002997335.1 similar to phage protein [bacteriophage 10750.2] YP_002997336.1 similar to hypothetical protein SpyM3_1322 [Streptococcus pyogenes MGAS315] YP_002997337.1 similar to phage scaffold protein [bacteriophage 10750.2] YP_002997338.1 similar to phage protein [bacteriophage 10750.2] YP_002997339.1 similar to phage protein [bacteriophage 10750.2] YP_002997340.1 similar to portal protein [bacteriophage 10750.2] YP_002997341.1 similar to Terminase large subunit [bacteriophage 10750.2] YP_002997342.1 similar to phage protein [bacteriophage 10750.2] YP_002997343.1 similar to phage protein [Streptococcus pyogenes MGAS10750] YP_002997344.1 similar to phage encoded transcriptional regulator ArpU family [bacteriophage 10750.2] YP_002997345.1 similar to hypothetical protein MGAS9429 Spy0819 [bacteriophage 9429.2] YP_002997346.1 similar to hypothetical protein SpyM50655 [Streptococcus pyogenes str. Manfredo] YP_002997347.1 no hit YP_002997348.1 similar to phage protein [Streptococcus pyogenes MGAS5005] YP_002997349.1 similar to hypothetical protein SpyoM01000037 [Streptococcus pyogenes M49 591] YP_002997350.1 similar to Orf80 [bacteriophage phi31.1] YP_002997351.1 no hit YP_002997352.1 similar to hypothetical protein spyM18 1285 [Streptococcus pyogenes MGAS8232] YP_002997353.1 similar to hypothetical protein SpyM3 1246 [Streptococcus pyogenes MGAS315] YP_002997354.1 similar to phage protein [bacteriophage 10750.1] YP_002997355.1 similar to phage protein [Streptococcus pyogenes MGAS6180] YP_002997356.1 similar to phage protein [Streptococcus pyogenes MGAS6180] YP_002997357.1 similar to single strand binding protein [Streptococcus pyogenes MGAS8232] YP_002997358.1 similar to phage single-strand DNA binding protein [Streptococcus pyogenes MGAS5005] YP_002997359.1 similar to phage protein [Streptococcus pyogenes MGAS5005] YP_002997360.1 similar to hypothetical protein SpyM3 1252 [Streptococcus pyogenes MGAS315] YP_002997361.1 similar to hypothetical protein spyM18 1799 [Streptococcus pyogenes MGAS8232] YP_002997362.1 similar to phage protein [Streptococcus pyogenes MGAS5005] YP_002997363.1 similar to phage DNA replication protein [Streptococcus pyogenes str. Manfredo] YP_002997364.1 similar to COG3935, primosome component and related proteins [Streptococcus pyogenes M49 591] YP_002997365.1 similar to phage protein [bacteriophage 10750.1] YP_002997366.1 similar to phage protein [Streptococcus pyogenes MGAS6180] YP_002997367.1 similar to phage protein [bacteriophage 10750.2] YP_002997368.1 similar to hypothetical protein SpyM50475 [Streptococcus pyogenes str. Manfredo] YP_002997369.1 similar to hypothetical protein SpyM50474 [Streptococcus pyogenes str. Manfredo] YP_002997370.1 similar to cI-like repressor metallo-prtoeinase motif - phage associated [Streptococcus pyogenes MGAS315] YP_002997371.1 similar to phage protein [Streptococcus pyogenes MGAS10750] YP_002997372.1 similar to hypothetical protein SPs0508 [Streptococcus pyogenes SSI-1] YP_002997373.1 similar to phage integrase [Streptococcus pyogenes MGAS8232] YP_002997374.1 binds RecA and inhibits RecA-mediated DNA strand exchange and ATP hydrolysis and coprotease activities YP_002997375.1 similar to hypothetical cytosolic protein [Streptococcus pyogenes MGAS10394] YP_002997376.1 similar to hypothetical protein Sez 1543 [Streptococcus equi subsp. zooepidemicus MGCS10565] YP_002997377.1 similar to transposase [Streptococcus pyogenes MGAS10270] YP_002997378.1 similar to ribosome-associated factor Y [Streptococcus pyogenes MGAS10394] YP_002997379.1 similar to late competence protein [Streptococcus pyogenes str. Manfredo] YP_002997380.1 similar to late competence protein required for DNA uptake [Streptococcus pyogenes M1 GAS] YP_002997381.1 similar to hypothetical protein Sez 1548 [Streptococcus equi subsp. zooepidemicus MGCS10565] YP_002997382.1 similar to cysteine synthase [Streptococcus pyogenes MGAS10750] YP_002997383.1 similar to S1-type RNA-binding domain [Streptococcus pyogenes MGAS10750] YP_002997384.1 similar to cyclophilin-type protein [Streptococcus pyogenes SSI-1] YP_002997385.1 similar to two-component response regulator [Streptococcus pyogenes SSI-1] YP_002997386.1 similar to two-component sensor protein yvqE [Streptococcus pyogenes MGAS10394] YP_002997387.1 similar to transporter yvqF [Streptococcus pyogenes MGAS10394] YP_002997388.1 similar to serine/threonine-protein kinase [Streptococcus pyogenes str. Manfredo] YP_002997389.1 similar to protein phosphatase 2C [Streptococcus pyogenes MGAS10394] YP_002997390.1 similar to 16S rRNA m(5)C 967 methyltransferase [Streptococcus pyogenes MGAS6180] YP_002997391.1 modifies the free amino group of the aminoacyl moiety of methionyl-tRNA(fMet) which is important in translation initiation; inactivation of this gene in Escherichia coli severely impairs growth YP_002997392.1 binding of PriA to forked DNA starts the assembly of the primosome, also possesses 3'-5' helicase activity YP_002997393.1 Promotes RNA polymerase assembly. Latches the N- and C-terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits YP_002997394.1 Essential for recycling GMP and indirectly, cGMP YP_002997395.1 similar to phosphohydrolase [Streptococcus pyogenes str. Manfredo] YP_002997396.1 similar to transcriptional regulators LysR family [Streptococcus pyogenes MGAS10394] YP_002997397.1 similar to acetyl-CoA acetyltransferase [Streptococcus pyogenes MGAS2096] YP_002997398.1 similar to acetate CoA-transferase alpha subunit [Streptococcus pyogenes MGAS5005] YP_002997399.1 similar to acetate CoA-transferase beta subunit [Streptococcus pyogenes MGAS5005] YP_002997400.1 similar to short chain dehydrogenase [Streptococcus pyogenes MGAS6180] YP_002997401.1 similar to D-beta-hydroxybutyrate permease [Streptococcus pyogenes MGAS10750] YP_002997402.1 catalyzes the hydrolysis of S-ribosylhomocysteine to homocysteine and autoinducer-2 YP_002997403.1 similar to hypothetical protein spyM18 1655 [Streptococcus pyogenes MGAS8232] YP_002997404.1 similar to methyltransferase [Streptococcus pyogenes MGAS10270] YP_002997405.1 similar to cell division initiation protein [Streptococcus pyogenes MGAS5005] YP_002997406.1 similar to hypothetical protein spyM18 1659 [Streptococcus pyogenes MGAS8232] YP_002997407.1 functions in homologous recombination, DNA repair, and chromosome segregation; binds preferentially to three- and four-stranded DNA intermediates; introduces specific nick sites in four-stranded DNA substrates; functions similarly to Escherichia coli RuvC YP_002997408.1 similar to multimodular transpeptidase-transglycosylase PBP 1A [Streptococcus pyogenes MGAS10750] YP_002997409.1 similar to aminopeptidase C [Streptococcus pyogenes MGAS315] YP_002997410.1 catalyzes the formation of nicotinamide adenine dinucleotide (NAD) from nicotinic acid adenine dinucleotide (NAAD) using either ammonia or glutamine as the amide donor and ATP; ammonia-utilizing enzymes include the ones from Bacillus and Escherichia coli while glutamine-utilizing enzymes include the Mycobacterial one; forms homodimers YP_002997411.1 catalyzes the formation of 5-phospho-alpha-D-ribose 1-diphosphate and nicotinate from nicotinate D-ribonucleotide and diphosphate YP_002997412.1 similar to amino acid permease [Streptococcus pyogenes MGAS6180] YP_002997413.1 similar to thioredoxin reductase [Streptococcus pyogenes MGAS10394] YP_002997414.1 similar to hypothetical protein SpyM50430 [Streptococcus pyogenes str. Manfredo] YP_002997415.1 similar to transporter [Streptococcus pyogenes MGAS6180] YP_002997416.1 similar to amino acid ABC transporter permease protein [Streptococcus pyogenes MGAS10394] YP_002997417.1 similar to amino-acid ABC transporter extracellular-binding protein precursor [Streptococcus equi subsp. zooepidemicus MGCS10565] YP_002997418.1 similar to ATP-dependent RNA helicase [Streptococcus pyogenes MGAS10394] YP_002997419.1 similar to hypothetical protein M6 Spy1410 [Streptococcus pyogenes MGAS10394] YP_002997420.1 First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan YP_002997421.1 similar to division specific DD-transpeptidase [Streptococcus pyogenes MGAS10394] YP_002997422.1 similar to cell division protein [Streptococcus pyogenes MGAS315] YP_002997423.1 similar to S-adenosyl-methyltransferase mraW [Streptococcus pyogenes MGAS10750] YP_002997424.1 similar to hypothetical protein M5005 Spy 1369 [Streptococcus pyogenes MGAS5005] YP_002997425.1 similar to hypothetical protein M6 Spy1417 [Streptococcus pyogenes MGAS10394] YP_002997426.1 similar to hypothetical protein MGAS10750 Spy1479 [Streptococcus pyogenes MGAS10750] YP_002997427.1 Catalyzes the phosphorylation of L-glutamate during the proline biosynthesis pathway YP_002997428.1 catalyzes the formation of glutamate 5-phosphate from glutamate in proline biosynthesis YP_002997429.1 similar to ABC transporter permease protein [Streptococcus pyogenes MGAS10750] YP_002997430.1 similar to ABC transporter ATP-binding protein [Streptococcus pyogenes MGAS5005] YP_002997431.1 similar to hypothetical protein MGAS2096 Spy1397 [Streptococcus pyogenes MGAS2096] YP_002997432.1 catalyzes the formation of ribose 5-phosphate and xylulose 5-phosphate from sedoheptulose 7-phosphate and glyceraldehyde 3-phosphate; can transfer ketol groups between several groups; in Escherichia coli there are two tkt genes, tktA expressed during exponential growth and the tktB during stationary phase YP_002997433.1 similar to novel fructose-6-phosphate aldolase from Escherichia coli; enzyme from Methanocaldococcus janaschii shows transaldolase activity YP_002997434.1 similar to conserved hypothetical protein [Listeria monocytogenes str. 1/2a F6854] YP_002997435.1 similar to trans-acting positive regulator [Streptococcus pyogenes MGAS10750] YP_002997436.1 similar to NADH peroxidase [Streptococcus pyogenes MGAS6180] YP_002997437.1 similar to glycerol uptake facilitator protein [Streptococcus pyogenes MGAS10394] YP_002997438.1 similar to apha-glycerophosphate oxidase [Streptococcus pyogenes MGAS10394] YP_002997439.1 Converts glycerol and ADP to glycerol-3-phosphate and ADP YP_002997440.1 similar to hypothetical protein spyM18 1698 [Streptococcus pyogenes MGAS8232] YP_002997441.1 similar to hypothetical protein M6 Spy1431 [Streptococcus pyogenes MGAS10394] YP_002997442.1 glycine--tRNA ligase beta chain; glyS; class II aminoacyl tRNA synthetase; tetramer of alpha(2)beta(2); catalyzes a two-step reaction; first charging a glycine molecule by linking the carboxyl group to the alpha-phosphate of ATP; second by transfer of the aminoacyl-adenylate to its tRNA YP_002997443.1 glycine--tRNA ligase alpha chain; GlyRS; class II aminoacyl tRNA synthetase; tetramer of alpha(2)beta(2); catalyzes a two-step reaction; first charging a glycine molecule by linking its carboxyl group to the alpha-phosphate of ATP; second by transfer of the aminoacyl-adenylate to its tRNA YP_002997446.1 similar to hypothetical protein SPy 1691 [Streptococcus pyogenes M1 GAS] YP_002997447.1 similar to 2,5-diketo-D-gluconic acid reductase [Streptococcus pyogenes MGAS10270] YP_002997448.1 similar to N-acetylglucosamine-6-phosphate deacetylase [Streptococcus pyogenes str. Manfredo] YP_002997449.1 similar to sodium-dependent phosphate transporter [Streptococcus pyogenes MGAS10750] YP_002997450.1 similar to lipoprotein [Streptococcus pyogenes str. Manfredo] YP_002997451.1 similar to DegV family protein [Streptococcus pyogenes MGAS10394] YP_002997452.1 similar to transcriptional regulator TetR family [Streptococcus pyogenes MGAS10394] YP_002997453.1 similar to hydrolase (HAD superfamily) [Streptococcus pyogenes MGAS10394] YP_002997454.1 similar to hypothetical membrane spanning protein [Streptococcus pyogenes MGAS10394] YP_002997455.1 probable ORF of C-terminal portion of tagatose 1,6-diphosphate aldolase [Streptococcus pyogenes MGAS315] resulted from mutation by unknown reason YP_002997456.1 probable ORF of N-terminal portion of tagatose 1,6-diphosphate aldolase [Streptococcus pyogenes MGAS315] resulted from mutation by unknown reason YP_002997457.1 similar to tagatose-6-phosphate kinase LacC [Streptococcus equi subsp. zooepidemicus MGCS10565] YP_002997458.1 catalyzes the interconversion of galactose 6-phosphate to tagatose 6-phosphate YP_002997459.1 catalyzes the interconversion of galactose 6-phosphate to tagatose YP_002997460.1 similar to transcriptional regulator [Streptococcus pyogenes MGAS2096] YP_002997461.1 similar to sugar phosphotransferase system (PTS)galactitol-specific family IIC component [Streptococcus pyogenes str. Manfredo] YP_002997462.1 similar to PTS system galactose-specific IIB component [Streptococcus pyogenes MGAS6180] YP_002997463.1 similar to PTS system enzyme IIA component [Streptococcus pyogenes M1 GAS] YP_002997464.1 similar to lactose phosphotransferase system repressor [Streptococcus pyogenes MGAS10394] YP_002997465.1 similar to copper chaperone [Streptococcus pyogenes MGAS6180] YP_002997466.1 similar to copper chaperone [Streptococcus pyogenes MGAS6180] YP_002997467.1 similar to copper-exporting ATPase [Streptococcus pyogenes MGAS2096] YP_002997468.1 similar to negative transcriptional regulator [Streptococcus pyogenes MGAS8232] YP_002997469.1 similar to transposase [Streptococcus agalactiae] YP_002997470.1 similar to hypothetical protein SPy 0130 [Streptococcus pyogenes M1 GAS] YP_002997471.1 similar to hypothetical protein SPy 0129 [Streptococcus pyogenes M1 GAS] YP_002997472.1 similar to transposase IS256 family [Streptococcus agalactiae 2603V/R] YP_002997473.1 similar to transposase IS256 family [Streptococcus agalactiae 2603V/R] YP_002997474.1 similar to hypothetical protein MGAS2096 Spy0117 [Streptococcus pyogenes MGAS2096] YP_002997475.1 similar to sortase B family protein [Streptococcus pyogenes MGAS2096] YP_002997476.1 similar to hypothetical protein M28 Spy0109 [Streptococcus pyogenes MGAS6180] YP_002997477.1 similar to signal peptidase I [Streptococcus pyogenes MGAS6180] YP_002997478.1 similar to collagen binding protein [Streptococcus pyogenes MGAS315] YP_002997479.1 similar to transcriptional regulator AraC family [Streptococcus equi subsp.zooepidemicus MGCS10565] YP_002997480.1 similar to ISSdy1 transposase OrfB [Streptococcus agalactiae 2603V/R] YP_002997481.1 similar to ISSdy1 transposase OrfB [Streptococcus agalactiae 2603V/R] YP_002997482.1 similar to hypothetical protein gbs1310 [Streptococcus agalactiae NEM316] YP_002997483.1 similar to transposase [Lactococcus lactis subsp. cremoris SK11] YP_002997484.1 similar to esterase [Streptococcus pyogenes MGAS2096] YP_002997485.1 associates with free 30S ribosomal subunits; essential for efficient processing of 16S rRNA; in Escherichia coli rbfA is induced by cold shock YP_002997486.1 Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits during initiation of protein synthesis. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex YP_002997487.1 similar to LSU ribosomal protein L7AE [Streptococcus pyogenes MGAS10750] YP_002997488.1 similar to hypothetical cytosolic protein [Streptococcus pyogenes MGAS10394] YP_002997489.1 modifies transcription through interactions with RNA polymerase affecting elongation, readthrough, termination, and antitermination YP_002997490.1 in Streptococcus pneumoniae this gene was found to be essential; structure determination of the Streptococcus protein shows that it is similar to a number of other proteins YP_002997491.1 tRNA (guanine-N(7)-)-methyltransferase; catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA by transferring the methyl residue from S-adenosyl-L-methionine YP_002997492.1 similar to phosphotransferase enzyme family protein [Streptococcus pyogenes str. Manfredo] YP_002997493.1 similar to protein ecsB [Streptococcus pyogenes MGAS10270] YP_002997494.1 similar to ABC transporter (ATP-binding protein) [Streptococcus pyogenes M1 GAS] YP_002997495.1 similar to cell-cycle regulation histidine triad protein HIT [Streptococcus equi subsp. zooepidemicus MGCS10565] YP_002997496.1 similar to COG0840, methyl-accepting chemotaxis protein [Streptococcus pyogenes M49 591] YP_002997497.1 similar to transcriptional regulator LytR family [Streptococcus pyogenes MGAS10394] YP_002997498.1 similar to acetyltransferase [Streptococcus pyogenes MGAS5005] YP_002997499.1 similar to ATP/GTP hydrolase [Streptococcus pyogenes MGAS10394] YP_002997500.1 similar to guanine-hypoxanthine permease [Streptococcus equi subsp. zooepidemicus MGCS10565] YP_002997501.1 similar to hydrolase HAD superfamily [Streptococcus pyogenes MGAS5005] YP_002997502.1 similar to PTS system mannose-specific IIAB component [Streptococcus pyogenes MGAS5005] YP_002997503.1 similar to PTS system mannose-specific IIC component [Streptococcus pyogenes MGAS5005] YP_002997504.1 similar to PTS system mannose-specific IID component [Streptococcus pyogenes MGAS5005] YP_002997505.1 similar to hypothetical cytosolic protein [Streptococcus pyogenes MGAS5005] YP_002997506.1 similar to hypothetical protein Sez 0419 [Streptococcus equi subsp. zooepidemicus MGCS10565] YP_002997507.1 catalyzes a two-step reaction, first charging a serine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA YP_002997508.1 catalyzes the carboxylation of acetyl-CoA to malonyl-CoA; forms a tetramer composed of two alpha (AccA) and two beta (AccD) subunits; one of the two catalytic subunits that can form the acetyl CoA carboxylase enzyme together with a carrier protein; these proteins present a shorter N-terminus YP_002997509.1 catalyzes the carboxylation of acetyl-CoA to malonyl-CoA; forms a tetramer of AccA2D2 subunits YP_002997510.1 an AccC homodimer forms the biotin carboxylase subunit of the acetyl CoA carboxylase, an enzyme that catalyzes the formation of malonyl-CoA, which in turn controls the rate of fatty acid metabolism YP_002997511.1 similar to (3R)-hydroxymyristoyl ACP dehydratase [Streptococcus pyogenes MGAS10394] YP_002997512.1 composes the biotin carboxyl carrier protein subunit of the acetyl-CoA carboxylase complex, the enzyme that catalyzes the carboxylation of acetyl-CoA to malonyl-CoA, which in turn controls the rate of fatty acid metabolism YP_002997513.1 FabF; beta-ketoacyl-ACP synthase II, KASII; catalyzes a condensation reaction in fatty acid biosynthesis: addition of an acyl acceptor of two carbons from malonyl-ACP; required for the elongation of short-chain unsaturated acyl-ACP YP_002997514.1 catalyzes the first of the two reduction steps in the elongation cycle of fatty acid synthesis YP_002997515.1 similar to acyl-carrier-protein S-malonyltransferase [Streptococcus pyogenes SSI-1] YP_002997516.1 similar to enoyl-[acyl-carrier protein] reductase (NADH) [Streptococcus pyogenes MGAS5005] YP_002997517.1 carries the fatty acid chain in fatty acid biosynthesis YP_002997518.1 FabH; beta-ketoacyl-acyl carrier protein synthase III; catalyzes the condensation of acetyl-CoA with malonyl-ACP to initiate cycles of fatty acid elongation; differs from 3-oxoacyl-(acyl carrier protein) synthase I and II in that it utilizes CoA thioesters as primers rather than acyl-ACPs YP_002997519.1 similar to transcriptional regulator MarR family [Streptococcus pyogenes MGAS6180] YP_002997520.1 Catalyzes the reversible hydration of unsaturated fatty acyl-CoA to beta-hydroxyacyl-CoA YP_002997521.1 chaperone Hsp40; co-chaperone with DnaK; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, dnaK-independent fashion YP_002997522.1 similar to 4-methyl-5(beta-hydroxyethyl)-thiazole monophosphate synthesis protein [Streptococcus gordonii str. Challis substr. CH1] YP_002997523.1 heat shock protein 70; assists in folding of nascent polypeptide chains; refolding of misfolded proteins; utilizes ATPase activity to help fold; co-chaperones are DnaJ and GrpE; multiple copies in some bacteria YP_002997524.1 similar to hypothetical protein FN0115 [Fusobacterium nucleatum subsp. nucleatum ATCC 25586] YP_002997525.1 with DnaK and DnaJ acts in response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins; may act as a thermosensor YP_002997526.1 Negative regulator of class I heat shock genes (grpE-dnaK-dnaJ and groELS operons). Prevents heat-shock induction of these operons YP_002997527.1 similar to N-acetyl-muramidase [Streptococcus pyogenes MGAS8232] YP_002997528.1 similar to DD-carboxypeptidase [Streptococcus pyogenes MGAS8232] YP_002997529.1 similar to phosphoglycerate mutase [Streptococcus pyogenes MGAS10394] YP_002997530.1 similar to hypothetical membrane spanning protein [Streptococcus pyogenes MGAS10394] YP_002997531.1 similar to drug/metabolite transporter (DMT) superfamily protein [Streptococcus equi subsp. zooepidemicus MGCS10565] YP_002997532.1 similar to transposase [Streptococcus pyogenes MGAS5005] YP_002997533.1 allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp-tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases; reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA YP_002997534.1 allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp-tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases; reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA YP_002997535.1 allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp-tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases; reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA; some Mycoplasma proteins contain an N-terminal fusion to an unknown domain YP_002997536.1 catalyzes the formation of phosphoenolpyruvate from pyruvate YP_002997537.1 similar to hypothetical protein SAG1671 [Streptococcus agalactiae 2603V/R] YP_002997538.1 similar to hypothetical protein [Streptococcus agalactiae 2603V/R] YP_002997539.1 similar to hypothetical protein STRINF 01222 [Streptococcus infantarius subsp. infantarius ATCC BAA-102] YP_002997540.1 similar to hypothetical protein STRINF 01221 [Streptococcus infantarius subsp. infantarius ATCC BAA-102] YP_002997541.1 similar to rhodanese-like [Enterococcus faecium DO] YP_002997542.1 similar to hypothetical protein STRINF 01219 [Streptococcus infantarius subsp. infantarius ATCC BAA-102] YP_002997543.1 nicotinamidase YP_002997544.1 CodY; DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase (By similarity). It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor YP_002997545.1 broad specificity; family IV; in Corynebacterium glutamicum this protein can use glutamate, 2-aminobutyrate, and aspartate as amino donors and pyruvate as the acceptor YP_002997546.1 similar to universal stress protein family [Streptococcus pyogenes MGAS6180] YP_002997547.1 similar to hydrolase (HAD superfamily) [Streptococcus equi subsp. zooepidemicus MGCS10565] YP_002997548.1 similar to L-asparaginase [Streptococcus pyogenes M1 GAS] YP_002997549.1 similar to oxidoreductase aldo/keto reductase family [Streptococcus agalactiae 2603V/R] YP_002997550.1 similar to ATP-dependent DNA helicase RecG [Streptococcus equi subsp. zooepidemicus MGCS10565] YP_002997551.1 similar to Cobalt transport ATP-binding protein cbiO [Streptococcus pyogenes MGAS2096] YP_002997552.1 similar to cobalt transport protein cbiQ [Streptococcus pyogenes MGAS5005] YP_002997553.1 similar to hypothetical protein SpyM3 1555 [Streptococcus pyogenes MGAS315] YP_002997554.1 similar to ABC transporter ATP-binding protein [Streptococcus pyogenes MGAS10270] YP_002997555.1 similar to ABC transporter (ATP-binding protein) [Streptococcus pyogenes MGAS8232] YP_002997556.1 similar to ferrichrome transport ATP-binding protein [Streptococcus pyogenes MGAS6180] YP_002997557.1 similar to ferrichrome transport system permease protein [Streptococcus pyogenes MGAS10394] YP_002997558.1 similar to ferrichrome-binding protein [Streptococcus pyogenes MGAS10750] YP_002997559.1 similar to hypothetical protein MGAS10270 Spy1597 [Streptococcus pyogenes MGAS10270] YP_002997560.1 similar to Fe3+-siderophore transport protein [Streptococcus pyogenes MGAS10750] YP_002997561.1 similar to immunogenic secreted protein [Streptococcus pyogenes MGAS6180] YP_002997562.1 converts L-alanine to D-alanine which is used in cell wall biosynthesis; binds one pyridoxal phosphate per monomer; forms a homodimer YP_002997563.1 Catalyzes the formation of holo-ACP, which mediates the essential transfer of acyl fatty acid intermediates during the biosynthesis of fatty acids and lipids YP_002997564.1 functions in protein export; can interact with acidic membrane phospholipids and the SecYEG protein complex; binds to preproteins; binds to ATP and undergoes a conformational change to promote membrane insertion of SecA/bound preprotein; ATP hydrolysis appears to drive release of the preprotein from SecA and deinsertion of SecA from the membrane; additional proteins SecD/F/YajC aid SecA recycling; exists in an equilibrium between monomers and dimers; may possibly form higher order oligomers; proteins in this cluster correspond SecA1; SecA2 is not essential and seems to play a role in secretion of a subset of proteins YP_002997565.1 similar to mannose-6-phosphate isomerase [Streptococcus pyogenes str. Manfredo] YP_002997566.1 similar to fructokinase [Streptococcus pyogenes MGAS10750] YP_002997567.1 similar to PTS system sucrose-specific IIABC component [Streptococcus pyogenes MGAS5005] YP_002997568.1 similar to sucrose-6-phosphate hydrolase [Streptococcus pyogenes MGAS10394] YP_002997569.1 similar to sucrose operon repressor [Streptococcus pyogenes MGAS5005] YP_002997570.1 Regulates rRNA biosynthesis by transcriptional antitermination YP_002997571.1 similar to general stress protein Gls24 family [Streptococcus pyogenes MGAS6180] YP_002997572.1 Involved in peptide bond synthesis; alters the affinity of the ribosome for aminoacyl-tRNA YP_002997573.1 similar to ComE operon protein 2 [Streptococcus pyogenes MGAS6180] YP_002997574.1 similar to Xaa-Pro dipeptidase [Streptococcus pyogenes MGAS6180] YP_002997575.1 The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate YP_002997576.1 similar to magnesium and cobalt transport protein corA [Streptococcus pyogenes MGAS10394] YP_002997577.1 similar to hypothetical membrane spanning protein [Streptococcus pyogenes MGAS5005] YP_002997578.1 binds as a heterodimer with protein S6 to the central domain of the 16S rRNA; helps stabilize the platform of the 30S subunit YP_002997579.1 binds to single stranded DNA and may facilitate the binding and interaction of other proteins to DNA YP_002997580.1 binds cooperatively with S18 to the S15-16S complex, allowing platform assembly to continue with S11 and S21 YP_002997581.1 similar to hypothetical protein SpyM50294 [Streptococcus pyogenes str. Manfredo] YP_002997582.1 similar to A/G-specific adenine glycosylase [Streptococcus equi subsp. zooepidemicus MGCS10565] YP_002997583.1 similar to thioredoxin [Streptococcus equi subsp. zooepidemicus MGCS10565] YP_002997584.1 Involved in disulfide oxidoreductase activity and electron transport YP_002997585.1 similar to recombination inhibitory protein MutS2 [Streptococcus equi subsp. zooepidemicus MGCS10565] YP_002997586.1 similar to colicin V production protein [Streptococcus pyogenes MGAS5005] YP_002997587.1 similar to hypothetical protein SpyM50287 [Streptococcus pyogenes str. Manfredo] YP_002997588.1 An endonuclease that specifically degrades the RNA strand of RNA-DNA hybrids YP_002997589.1 similar to signal peptidase I [Streptococcus pyogenes MGAS10394] YP_002997590.1 similar to exodeoxyribonuclease V alpha chain [Streptococcus pyogenes MGAS5005] YP_002997591.1 similar to hypothetical protein SPs0273 [Streptococcus pyogenes SSI-1] YP_002997592.1 involved in translesion DNA polymerization with beta clamp of polymerase III; belongs to Y family of polymerases; does not contain proofreading function YP_002997593.1 similar to formate acetyltransferase [Streptococcus pyogenes MGAS5005] YP_002997594.1 similar to acetyltransferase GNAT family [Streptococcus thermophilus LMD-9] YP_002997595.1 similar to alpha amylase catalytic region [Chloroflexus aurantiacus J-10-fl] YP_002997596.1 similar to ABC-type sugar transport system periplasmic component [Lactococcus lactis subsp. cremoris SK11] YP_002997597.1 similar to hypothetical protein llmg 1837 [Lactococcus lactis subsp. cremoris MG1363] YP_002997598.1 similar to ABC-type sugar transport system permease component [Lactococcus lactis subsp. cremoris SK11] YP_002997599.1 similar to ABC-type polysaccharide transport system permease component [Lactococcus lactis subsp. cremoris SK11] YP_002997600.1 similar to regulatory protein LacI [Clostridium beijerinckii NCIMB 8052] YP_002997601.1 similar to beta-lactamase family protein [Streptococcus pyogenes MGAS2096] YP_002997602.1 similar to hypothetical cytosolic protein [Streptococcus pyogenes MGAS10750] YP_002997603.1 similar to hypothetical membrane spanning protein [Streptococcus pyogenes MGAS2096] YP_002997604.1 similar to hypothetical protein SSU98 0262 [Streptococcus suis 98HAH33] YP_002997605.1 catalyzes the removal of N-terminal dipeptides when proline is the penultimate residue YP_002997606.1 similar to hypothetical protein Sez 0318 [Streptococcus equi subsp. zooepidemicus MGCS10565] YP_002997607.1 similar to hypothetical protein spyM18 1923 [Streptococcus pyogenes MGAS8232] YP_002997608.1 similar to transcriptional regulator [Streptococcus pyogenes MGAS6180] YP_002997609.1 similar to hypothetical cytosolic protein [Streptococcus pyogenes MGAS2096] YP_002997610.1 similar to transcriptional regulator MerR family [Streptococcus pyogenes MGAS5005] YP_002997611.1 3'-5' exonuclease of DNA polymerase III YP_002997612.1 similar to DNA-binding protein [Streptococcus pyogenes str. Manfredo] YP_002997613.1 similar to transposase [Streptococcus criceti] YP_002997614.1 similar to hypothetical protein SPs0257 [Streptococcus pyogenes SSI-1] YP_002997615.1 similar to hypothetical protein [Streptococcus thermophilus] YP_002997616.1 located in the peptidyl transferase center and involved in assembly of 30S ribosome subunit; similar to what is observed with proteins L31 and L33, some proteins in this family contain CXXC motifs that are involved in zinc binding; if two copies are present in a genome, then the duplicated copy appears to have lost the zinc-binding motif and is instead regulated by zinc; the proteins in this group do not appear to have the zinc-binding motif YP_002997617.1 in most organisms, only the N-terminal domain is present in a single polypeptide; in some archaea this domain is fused to a kinase domain; this gene is essential for growth in Escherichia coli and Bacillus subtilis; the secreted glycoprotease from Pasteurella haemolytica showed specificity for O-sialoglycosylated proteins; the Pyrococcus structure shows DNA-binding properties, iron-binding, ATP-binding, and AP endonuclease activity YP_002997618.1 similar to ribosomal-protein-alanine acetyltransferase [Streptococcus pyogenes MGAS6180] YP_002997619.1 similar to non-proteolytic protein peptidase family M22 [Streptococcus pyogenes MGAS10270] YP_002997620.1 similar to hypothetical protein SpyM50257 [Streptococcus pyogenes str. Manfredo] YP_002997621.1 similar to Zn-dependent hydrolase [Streptococcus pyogenes MGAS10394] YP_002997622.1 similar to oligopeptide transport ATP-binding protein OppF [Streptococcus equi subsp. zooepidemicus MGCS10565] YP_002997623.1 similar to oligopeptide transport ATP-binding protein OppD [Streptococcus equi subsp. zooepidemicus MGCS10565] YP_002997624.1 similar to oligopeptide transport system permease protein OppC [Streptococcus equi subsp. zooepidemicus MGCS10565] YP_002997625.1 similar to oligopeptide transport system permease protein OppB [Streptococcus equi subsp. zooepidemicus MGCS10565] YP_002997626.1 similar to oligopeptide-binding protein OppA precursor [Streptococcus equi subsp. zooepidemicus MGCS10565] YP_002997627.1 similar to glutamine synthetase [Streptococcus pyogenes str. Manfredo] YP_002997628.1 similar to transcriptional regulator MerR family [Streptococcus pyogenes MGAS10394] YP_002997629.1 similar to hypothetical protein SpyM50253 [Streptococcus pyogenes str. Manfredo] YP_002997630.1 Converts 3-phospho-D-glycerate to 3-phospho-D-glyceroyl phosphate during the glycolysis pathway YP_002997631.1 similar to acid phosphatase [Streptococcus dysgalactiae subsp. equisimilis] YP_002997632.1 similar to glyceraldehyde-3-phosphate dehydrogenaseplasmin receptor [Streptococcus pyogenes str. Manfredo] YP_002997633.1 EF-G; promotes GTP-dependent translocation of the ribosome during translation; many organisms have multiple copies of this gene YP_002997634.1 binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit YP_002997635.1 interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone; located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side; mutations in the S12 gene confer streptomycin resistance YP_002997636.1 similar to surface exclusion protein [Streptococcus pyogenes MGAS10750] YP_002997637.1 similar to purine operon repressor [Streptococcus pyogenes MGAS10394] YP_002997638.1 similar to CMP-binding factor [Streptococcus pyogenes MGAS5005] YP_002997639.1 similar to RmuC family protein [Streptococcus pyogenes MGAS10394] YP_002997640.1 similar to thiamine pyrophosphokinase [Streptococcus pyogenes MGAS5005] YP_002997641.1 catalyzes the interconversion of D-ribulose 5-phosphate to xylulose 5-phosphate YP_002997642.1 EngC; RsgA; CpgA; circularly permuted GTPase; ribosome small subunit-dependent GTPase A; has the pattern G4-G1-G3 as opposed to other GTPases; interacts strongly with 30S ribosome which stimulates GTPase activity YP_002997643.1 catalyzes the transfer of a total of four methyl groups from S-adenosyl-l-methionine (S-AdoMet) to two adjacent adenosine bases A1518 and A1519 in 16S rRNA; mutations in ksgA causes resistance to the translation initiation inhibitor kasugamycin YP_002997644.1 similar to ribonuclease M5 [Streptococcus pyogenes MGAS6180] YP_002997645.1 similar to TatD related DNase [Streptococcus pyogenes str. Manfredo] YP_002997646.1 similar to hydrolase [Staphylococcus aureus RF122] YP_002997647.1 similar to transcriptional regulator RpiR family [Streptococcus pyogenes MGAS5005] YP_002997648.1 similar to N-acetylmannosamine kinase [Streptococcus pyogenes MGAS10394] YP_002997649.1 similar to N-acetylneuraminate lyase [Streptococcus pyogenes MGAS5005] YP_002997650.1 similar to hypothetical membrane spanning protein [Streptococcus pyogenes MGAS5005] YP_002997651.1 similar to hypothetical protein spyM18 0238 [Streptococcus pyogenes MGAS8232] YP_002997652.1 similar to N-acetylneuraminate transport system permease protein [Streptococcus pyogenes MGAS6180] YP_002997653.1 similar to N-acetylneuraminate transport system permease protein [Streptococcus pyogenes MGAS6180] YP_002997654.1 similar to N-acetylneuraminate-binding protein [Streptococcus pyogenes MGAS5005] YP_002997655.1 Converts N-acetylmannosamine-6-phosphate to N-acetylglucosamine-6-phosphate YP_002997656.1 in Escherichia coli transcription of this gene is enhanced by polyamines YP_002997657.1 similar to jag protein [Streptococcus pyogenes MGAS5005] YP_002997658.1 similar to membrane protein oxaA 1 precursor [Streptococcus pyogenes NZ131] YP_002997659.1 protein component of RNaseP which catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'terminus; this enzyme also cleaves other RNA substrates YP_002997660.1 similar to response regulator FasA [Streptococcus dysgalactiae subsp. equisimilis] YP_002997661.1 similar to sensory transduction protein kinase [Streptococcus pyogenes MGAS6180] YP_002997662.1 similar to FasB [Streptococcus pyogenes MGAS10394] YP_002997663.1 Charges one glutamine molecule and pairs it to its corresponding RNA trinucleotide during protein translation YP_002997664.1 similar to lantibiotic efflux protein [Streptococcus suis 05ZYH33] YP_002997665.1 similar to hypothetical protein SSA 1981 [Streptococcus sanguinis SK36] YP_002997666.1 similar to response regulator of the LytR/AlgR family [Streptococcus suis 98HAH33] YP_002997667.1 similar to HTH DNA-binding protein [Streptococcus equi subsp. zooepidemicus MGCS10565] YP_002997668.1 similar to carbonic anhydrase [Streptococcus pyogenes MGAS10394] YP_002997669.1 similar to DNA repair protein [Streptococcus pyogenes str. Manfredo] YP_002997670.1 catalyzes the formation of dUMP from dUTP YP_002997671.1 similar to hypothetical cytosolic protein [Streptococcus pyogenes MGAS6180] YP_002997672.1 similar to multidrug resistance ABC transporter ATP-binding and permease protein [Streptococcus pyogenes MGAS10394] YP_002997673.1 similar to ABC transporter ATP-binding protein [Streptococcus pyogenes M1 GAS] YP_002997674.1 similar to hypothetical protein spyM18 0213 [Streptococcus pyogenes MGAS8232] YP_002997675.1 catalyzes the NAD(P)H-dependent reduction of glycerol 3-phosphate to glycerone phosphate YP_002997676.1 similar to UDP-glucose pyrophosphorylase [Streptococcus pyogenes MGAS8232] YP_002997677.1 similar to integral membrane protein [Lactobacillus plantarum WCFS1] YP_002997678.1 similar to integral membrane protein (rhomboid family) [Streptococcus pyogenes MGAS10394] YP_002997679.1 similar to 5-formyltetrahydrofolate cyclo-ligase family protein [Streptococcus agalactiae 2603V/R] YP_002997680.1 similar to fibronectin-binding protein [Streptococcus equi subsp. zooepidemicus] YP_002997681.1 similar to transcriptional regulator [Streptococcus pyogenes MGAS10270] YP_002997682.1 similar to hypothetical protein llmg 0526 [Lactococcus lactis subsp. cremoris MG1363] YP_002997683.1 similar to hypothetical protein BIFDEN 02311 [Bifidobacterium dentium ATCC 27678] YP_002997684.1 functions in sugar metabolism in glycolysis and the Embden-Meyerhof pathways (EMP) and in gluconeogenesis; catalyzes reversible isomerization of glucose-6-phosphate to fructose-6-phosphate; member of PGI family YP_002997685.1 similar to hypothetical protein; hypothetical protein [Streptococcus dysgalactiae subsp. equisimilis] YP_002997686.1 similar to hypothetical protein [Streptococcus dysgalactiae subsp. equisimilis] YP_002997687.1 similar to exotoxin G variant 4 [Streptococcus dysgalactiae subsp. equisimilis] YP_002997688.1 similar to hypothetical protein [Streptococcus dysgalactiae subsp. equisimilis] YP_002997689.1 similar to peptidoglycan endo-beta-N-acetylglucosaminidase [Streptococcus pyogenes MGAS10394] YP_002997690.1 similar to tRNA-specific adenosine deaminase [Streptococcus pyogenes MGAS10394] YP_002997691.1 similar to metal-dependent hydrolase [Streptococcus pyogenes MGAS10394] YP_002997692.1 similar to BioY protein [Streptococcus pyogenes MGAS10750] YP_002997693.1 similar to zinc finger protein [Streptococcus pyogenes MGAS6180] YP_002997694.1 Exchanges the guanine residue with 7-aminomethyl-7-deazaguanine in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr) YP_002997695.1 similar to integral membrane protein [Streptococcus pyogenes MGAS6180] YP_002997696.1 similar to ferric uptake regulation protein [Streptococcus pyogenes MGAS5005] YP_002997697.1 similar to CoA binding protein [Streptococcus pyogenes MGAS10270] YP_002997698.1 has 3'-5' exonuclease, 5'-3' exonuclease and 5'-3'polymerase activities, primarily functions to fill gaps during DNA replication and repair YP_002997699.1 similar to glycine betaine-binding protein / glycine betaine transport system permease protein [Streptococcus pyogenes MGAS10750] YP_002997700.1 similar to glycine betaine transport ATP-binding protein [Streptococcus pyogenes str. Manfredo] YP_002997701.1 similar to diacylglycerol kinase catalytic subunit [Enterococcus faecalis YP_002997702.1 similar to metal-dependent hydrolase [Streptococcus pyogenes MGAS10394] YP_002997703.1 similar to transcription antiterminator BglG family [Streptococcus pyogenes MGAS10394] YP_002997704.1 catalyzes the formation of D-xylulose 5-phosphate from L-ribulose 5-phosphate in the L-arabinose and L-ascorbate degradation pathways YP_002997705.1 L-xylulose 5-phosphate 3-epimerase activity not yet demonstrated; may be involved in the utilization of 2,3-diketo-L-gulonate YP_002997706.1 catalyzes the formation of L-xylulose-5-phosphate from 3-keto-L-gulonate-6-phosphate in anaerobic L-ascorbate utilization YP_002997707.1 similar to PTS system 3-keto-L-gulonate specific IIA component [Streptococcus pyogenes MGAS10750] YP_002997708.1 similar to PTS system 3-keto-L-gulonate specific IIB component [Streptococcus pyogenes MGAS10394] YP_002997709.1 membrane component; functions with enzymes IIB (sgaB; ulaB) and IIA (sgaA; ulaC) enzyme I and HPr for anaerobic utilization and uptake of L-ascorbate; sgaTBA are regulated by yifQ as well as Crp and Fnr YP_002997710.1 leucine--tRNA ligase; LeuRS; class-I aminoacyl-tRNA synthetase; charges leucine by linking carboxyl group to alpha-phosphate of ATP and then transfers aminoacyl-adenylate to its tRNA; due to the large number of codons that tRNA(Leu) recognizes, the leucyl-tRNA synthetase does not recognize the anticodon loop of the tRNA, but instead recognition is dependent on a conserved discriminator base A37 and a long arm; an editing domain hydrolyzes misformed products; in Methanothermobacter thermautotrophicus this enzyme associates with prolyl-tRNA synthetase YP_002997711.1 similar to hypothetical protein MGAS2096 Spy1064 [Streptococcus pyogenes MGAS2096] YP_002997712.1 similar to transposase [Streptococcus pyogenes MGAS10750] YP_002997713.1 similar to transposase [Streptococcus pyogenes MGAS10394] YP_002997714.1 similar to ISSag4 transposase orfA [Streptococcus agalactiae A909] YP_002997715.1 similar to ISSdy1 transposase OrfB [Streptococcus agalactiae 2603V/R] YP_002997716.1 similar to ISSdy1 transposase OrfB [Streptococcus agalactiae 2603V/R] YP_002997717.1 no hit YP_002997718.1 similar to ABC transporter ATP-binding /membrane spanning permease - possible multidrug resistance [Carnobacterium sp. AT7] YP_002997719.1 no hit YP_002997720.1 similar to transposase [Streptococcus pyogenes MGAS2096] YP_002997721.1 similar to hypothetical protein M28 Spy0140 [Streptococcus pyogenes MGAS6180] YP_002997722.1 similar to streptolysin O precursor (Thiol-activated cytolysin) YP_002997723.1 similar to streptococcal NAD glycohydrolase inhibitor [Streptococcus pyogenes MGAS10270] YP_002997724.1 similar to NADase [Streptococcus dysgalactiae subsp. equisimilis] YP_002997725.1 Modulates Rho-dependent transcription termination YP_002997726.1 forms a complex with SecY and SecG; SecYEG forms a protein-conducting channel to which secA binds and translocates targeted polypeptides across the cytoplasmic membrane, a process driven by ATP and a proton-motive force YP_002997727.1 in Escherichia coli BM108, a mutation that results in lack of L33 synthesis had no effect on ribosome synthesis or function; there are paralogous genes in several bacterial genomes, and a CXXC motif for zinc binding and an upstream regulation region of the paralog lacking this motif that are regulated by zinc similar to other ribosomal proteins like L31; the proteins in this group have the CXXC motif YP_002997728.1 similar to penicillin-binding protein 2a [Streptococcus pyogenes SSI-1] YP_002997729.1 similar to translation initiation inhibitor [Streptococcus equi subsp. zooepidemicus MGCS10565] YP_002997730.1 similar to hypothetical cytosolic protein [Streptococcus pyogenes MGAS10750] YP_002997731.1 similar to ribosomal large subunit pseudouridine synthase D [Streptococcus pyogenes MGAS6180] YP_002997732.1 similar to hypothetical protein M5005 Spy 1757 [Streptococcus pyogenes MGAS5005] YP_002997733.1 similar to dipeptidase [Streptococcus pyogenes MGAS10270] YP_002997734.1 similar to MutT/Nudix family protein [Streptococcus equi subsp. zooepidemicus MGCS10565] YP_002997735.1 60 kDa chaperone family; promotes refolding of misfolded polypeptides especially under stressful conditions; forms two stacked rings of heptamers to form a barrel-shaped 14mer; ends can be capped by GroES; misfolded proteins enter the barrel where they are refolded when GroES binds; many bacteria have multiple copies of the groEL gene which are active under different environmental conditions; the B.japonicum protein in this cluster is expressed constitutively; in Rhodobacter, Corynebacterium and Rhizobium this protein is essential for growth YP_002997736.1 10 kDa chaperonin; Cpn10; GroES; forms homoheptameric ring; binds to one or both ends of the GroEL double barrel in the presence of adenine nucleotides capping it; folding of unfolded substrates initiates in a GroEL-substrate bound and capped by GroES; release of the folded substrate is dependent on ATP binding and hydrolysis in the trans ring YP_002997737.1 similar to negative regulator of genetic competence clpC/mecB [Streptococcus pyogenes MGAS10270] YP_002997738.1 similar to transcriptional regulator ctsR [Streptococcus pyogenes MGAS2096] YP_002997739.1 similar to cold shock protein [Streptococcus pyogenes MGAS5005] YP_002997740.1 similar to transposase [Streptococcus criceti] YP_002997741.1 similar to transposase [Streptococcus pyogenes MGAS2096] YP_002997742.1 similar to amidohydrolase 2 [Sphingomonas wittichii RW1] YP_002997743.1 similar to amidohydrolase 2 [Sphingomonas wittichii RW1] YP_002997744.1 similar to IS1562 transposase [Streptococcus pyogenes MGAS8232] YP_002997745.1 similar to transposase [Streptococcus pyogenes MGAS10394] YP_002997746.1 similar to transposase [Streptococcus pyogenes MGAS10750] YP_002997747.1 similar to alkyl hydroperoxidase [Streptococcus pyogenes M1 GAS] YP_002997748.1 similar to NADH dehydrogenase [Streptococcus pyogenes str. Manfredo] YP_002997749.1 catalyzing the hydrolysis of 4-imidazolone-5-propionate to N-formimidoyl-L-glutamate, the third step in the histidine degradation pathway YP_002997750.1 catalyzes the formation of 4-imidazolone-5-propanoate from urocanate during histidine metabolism YP_002997751.1 similar to glutamate formiminotransferase [Streptococcus pyogenes MGAS10394] YP_002997752.1 similar to formiminotetrahydrofolate cyclodeaminase [Streptococcus pyogenes MGAS2096] YP_002997753.1 catalyzes the formation of 10-formyltetrahydrofolate from formate and tetrahydrofolate YP_002997754.1 similar to hypothetical protein spyM18 2145 [Streptococcus pyogenes MGAS8232] YP_002997755.1 similar to aminoacid permease [Streptococcus pyogenes MGAS10394] YP_002997756.1 catalyzes the degradation of histidine to urocanate and ammmonia YP_002997757.1 catalyzes the formation of glutamate and formamide from N-formimidoyl-L-glutamate YP_002997758.1 similar to transcriptional regulator LuxR family [Streptococcus pyogenesMGAS10750] YP_002997759.1 one of the last subunits in the assembly of the 30S subunit; absence of S2 does not inhibit assembly but results in an inactive subunit YP_002997760.1 EF-Ts; functions during elongation stage of protein translation; forms a dimer; associates with EF-Tu-GDP complex and promotes exchange of GDP to GTP resulting in regeneration of the active form of EF-Tu YP_002997761.1 similar to oligoendopeptidase O [Streptococcus pyogenes MGAS2096] YP_002997762.1 similar to trehalose-6-phosphate hydrolase [Streptococcus pyogenes MGAS2096] YP_002997763.1 similar to PTS system trehalose-specific IIBC component / PTS system trehalose-specific IIA component [Streptococcus pyogenes MGAS2096] YP_002997764.1 similar to trehalose operon transcriptional repressor [Streptococcus pyogenes MGAS10394] YP_002997765.1 similar to hypothetical protein spyM18 2160 [Streptococcus pyogenes MGAS8232] YP_002997766.1 similar to hypothetical cytosolic protein [Streptococcus pyogenes MGAS10750] YP_002997767.1 similar to anaerobic ribonucleoside-triphosphate reductase activating protein [Streptococcus pyogenes MGAS10394] YP_002997768.1 similar to acetyltransferase [Streptococcus pyogenes MGAS10750] YP_002997769.1 similar to Mvi [Streptococcus pyogenes MGAS10394] YP_002997770.1 similar to hypothetical protein STRINF 00502 [Streptococcus infantarius subsp. infantarius ATCC BAA-102] YP_002997771.1 Catalyzes the reduction of nucleoside 5'-triphosphates to 2'-deoxynucleoside 5'-triphosphates YP_002997772.1 similar to hypothetical membrane spanning protein [Streptococcus pyogenes MGAS2096] YP_002997773.1 similar to hypothetical cytosolic protein [Streptococcus pyogenes MGAS10750] YP_002997774.1 similar to Holliday junction resolvase-like protein [Streptococcus pyogenes MGAS8232] YP_002997775.1 similar to hypothetical protein M6 Spy1796 [Streptococcus pyogenes MGAS10394] YP_002997776.1 the anti-alpha factor Spx interacts with RNA polymerase alpha subunit C-terminal domain in a region that interacts with the sigma 70 subunit and may interfere with activation of promoters; in Bacillus subtilis this protein is a substrate for ClpXP protease; blocks transcription of the competence regulatory gene encoded by the srf operon; regulates a number of genes involved in thiol homeostasis including trxA and trxB; monomeric member of ArsC family of proteins; does not bind DNA; contains a disulfide bond between C10 and C13 which may sense disulfide stress YP_002997777.1 catalyzes the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs YP_002997778.1 similar to colligrin [Streptococcus pyogenes MGAS10270] YP_002997779.1 similar to glyoxalase family protein superfamily [Streptococcus gordonii str. Challis substr. CH1] YP_002997780.1 similar to DNA-3-methyladenine glycosylase I [Streptococcus pyogenes str. Manfredo] YP_002997781.1 plays an essential role in ATP-dependent branch migration of the Holliday junction YP_002997782.1 similar to transporter protein [Streptococcus pyogenes str. Manfredo] YP_002997783.1 This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. Promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex YP_002997784.1 This protein performs the mismatch recognition step during the DNA repair process YP_002997785.1 similar to hypothetical protein Sez 1884 [Streptococcus equi subsp. zooepidemicus MGCS10565] YP_002997786.1 similar to arginine repressor [Streptococcus pyogenes MGAS5005] YP_002997787.1 catalyzes a two-step reaction, first charging an arginine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; class-I aminoacyl-tRNA synthetase YP_002997788.1 similar to ABC transporter ATP-binding protein [Streptococcus equi subsp. zooepidemicus MGCS10565] YP_002997789.1 similar to transporter [Streptococcus equi subsp. zooepidemicus MGCS10565] YP_002997790.1 similar to hypothetical membrane spanning protein [Streptococcus pyogenes MGAS10394] YP_002997791.1 similar to hypothetical membrane spanning protein [Streptococcus pyogenes MGAS5005] YP_002997792.1 catalyzes a two-step reaction, first charging an aspartate molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; contains discriminating and non-discriminating subtypes YP_002997793.1 catalyzes a two-step reaction, first charging a histidine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; class II aminoacyl-tRNA synthetase; forms homodimers; some organisms have a paralogous gene, hisZ, that is similar to hisS and produces a protein that performs the first step in histidine biosynthesis along with HisG YP_002997794.1 some L32 proteins have zinc finger motifs consisting of CXXC while others do not YP_002997795.1 in Escherichia coli BM108, a mutation that results in lack of L33 synthesis had no effect on ribosome synthesis or function; there are paralogous genes in several bacterial genomes, and a CXXC motif for zinc binding and an upstream regulation region of the paralog lacking this motif that are regulated by zinc similar to other ribosomal proteins like L31; the proteins in this group lack the CXXC motif YP_002997796.1 similar to cadmium resistance protein [Streptococcus pyogenes MGAS5005] YP_002997797.1 similar to cadmium efflux system accessory protein [Streptococcus pyogenes MGAS5005] YP_002997798.1 similar to hypothetical protein MGAS10270 Spy1911 [Streptococcus pyogenes MGAS10270] YP_002997799.1 similar to FtsK/SpoIIIE family [Streptococcus pyogenes MGAS10750] YP_002997800.1 similar to hypothetical protein SPy 2166 [Streptococcus pyogenes M1 GAS] YP_002997801.1 similar to transcriptional regulator [Streptococcus pyogenes MGAS2096] YP_002997802.1 similar to hypothetical protein M6 Spy1842 [Streptococcus pyogenes MGAS10394] YP_002997803.1 similar to integral membrane protein [Streptococcus pyogenes MGAS6180] YP_002997804.1 similar to NUDIX hydrolase [Streptococcus pyogenes str. Manfredo] YP_002997805.1 similar to hypothetical protein SpyM3 1828 [Streptococcus pyogenes MGAS315] YP_002997806.1 similar to hypothetical membrane associated protein [Streptococcus pyogenes MGAS9429] YP_002997807.1 similar to hypothetical membrane associated protein [Streptococcus pyogenes MGAS2096] YP_002997808.1 similar to phage protein [Streptococcus pyogenes MGAS6180] YP_002997809.1 similar to transcriptional regulator (TetR/AcrR family) [Streptococcus pyogenes MGAS315] YP_002997810.1 similar to transposase [Streptococcus pyogenes MGAS10394] YP_002997811.1 similar to transposase [Streptococcus pyogenes MGAS10750] YP_002997812.1 similar to RelE-domain protein [Streptococcus pyogenes MGAS6180] YP_002997813.1 similar to RelB protein [Streptococcus pyogenes MGAS10270] YP_002997814.1 similar to phage encoded transcriptional regulator ArpU family [Streptococcus pyogenes MGAS10394] YP_002997815.1 similar to phage protein [Streptococcus pyogenes MGAS6180] YP_002997816.1 similar to phage protein [Streptococcus pyogenes MGAS6180] YP_002997817.1 similar to phage protein [Streptococcus pyogenes MGAS6180] YP_002997818.1 similar to phage protein [Streptococcus pyogenes MGAS6180] YP_002997819.1 similar to phage protein [Streptococcus pyogenes MGAS6180] YP_002997820.1 similar to phage protein [Streptococcus pyogenes MGAS6180] YP_002997821.1 similar to phage protein [Streptococcus pyogenes MGAS6180] YP_002997822.1 similar to phage protein [Streptococcus pyogenes MGAS6180] YP_002997823.1 similar to phage protein [Streptococcus pyogenes MGAS6180] YP_002997824.1 similar to phage protein [Streptococcus phage 10270.4] YP_002997825.1 similar to phage protein [Streptococcus pyogenes MGAS6180] YP_002997826.1 similar to bacteriophage resistance protein [Streptococcus pyogenes MGAS10270] YP_002997827.1 similar to phage protein [Streptococcus pyogenes MGAS10270] YP_002997828.1 similar to phage protein [Streptococcus pyogenes MGAS10270] YP_002997829.1 similar to phageprotein [Streptococcus pyogenes MGAS6180] YP_002997830.1 similar to prophage antirepressor [Streptococcus pyogenes MGAS10270] YP_002997831.1 similar to phage antirepressor protein [Streptococcus pyogenes MGAS10270] YP_002997832.1 similar to phage protein [Streptococcus pyogenes MGAS10270] YP_002997833.1 similar to phage transcriptional regulator Cro/CI family [Streptococcus phage 10270.5] YP_002997834.1 no hit YP_002997835.1 similar to DNA integration/recombination /inversion protein [Streptococcus phage 10270.5] YP_002997836.1 primary rRNA binding protein; nucleates 30S assembly; involved in translational accuracy with proteins S5 and S12; interacts with protein S5; involved in autogeneously regulating ribosomal proteins by binding to pseudoknot structures in the polycistronic mRNA; interacts with transcription complex and functions similar to protein NusA in antitermination YP_002997837.1 similar to hypothetical protein spyM18 2216 [Streptococcus pyogenes MGAS8232] YP_002997838.1 unwinds double stranded DNA YP_002997839.1 in Escherichia coli this protein is wrapped around the base of the L1 stalk YP_002997840.1 similar to phosphoesterase DHH family protein [Streptococcus pyogenes MGAS2096] YP_002997841.1 GidA; glucose-inhibited cell division protein A; involved in the 5-carboxymethylaminomethyl modification (mnm(5)s(2)U) of the wobble uridine base in some tRNAs YP_002997842.1 similar to phosphohydrolase [Streptococcus pyogenes MGAS6180] YP_002997843.1 similar to hypothetical protein SAG2143 [Streptococcus agalactiae 2603V/R] YP_002997844.1 catalyzes a sulfuration reaction to synthesize 2-thiouridine at the U34 position of tRNAs YP_002997845.1 similar to L-serinedehydratase beta subunit [Streptococcus pyogenes MGAS10750] YP_002997846.1 similar to L-serinedehydratase alpha subunit [Streptococcus pyogenes MGAS10270] YP_002997847.1 similar to phosphoglycolate phosphatase [Streptococcus equi subsp. zooepidemicus MGCS10565] YP_002997848.1 similar to transglycosylase SLT domain family protein [Streptococcus pyogenes MGAS10394] YP_002997849.1 similar to cobalt transport protein cbiQ [Streptococcus pyogenes MGAS10394] YP_002997850.1 with CbiNQ forms the ABC transporter for cobalt import; Streptococcus has two adjacent copies of this gene YP_002997851.1 with CbiNQ forms the ABC transporter for cobalt import; Streptococcus has two adjacent copies of this gene YP_002997852.1 similar to CDP-diacylglycerol-glycerol-3-phosphate 3-phosphatidyltransferase PgsA [Streptococcus equi subsp. zooepidemicus MGCS10565] YP_002997853.1 similar to hypothetical membrane associated protein [Streptococcus pyogenes MGAS6180] YP_002997854.1 similar to zinc protease [Streptococcus pyogenes MGAS10750] YP_002997855.1 similar to zinc protease [Streptococcus pyogenes MGAS10394] YP_002997856.1 similar to hypothetical cytosolic protein [Streptococcus pyogenes MGAS10750] YP_002997857.1 Required for DNA replication; binds preferentially to single-stranded, linear DNA YP_002997858.1 similar to glucose uptake family protein [Streptococcus pyogenes MGAS9429] YP_002997859.1 catalyzes the synthesis of xanthosine monophosphate by the NAD+ dependent oxidation of inosine monophosphate YP_002997860.1 catalyzes a two-step reaction, first charging a tryptophan molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA YP_002997861.1 similar to hypothetical protein M6 Spy1877 [Streptococcus pyogenes MGAS10394] YP_002997862.1 similar to hypothetical protein SPy 2209 [Streptococcus pyogenes M1 GAS] YP_002997863.1 similar to ABC transporter ATP-binding protein [Streptococcus pyogenes str. Manfredo] YP_002997864.1 similar to ABC transporter permease protein [Streptococcus pyogenes MGAS10270] YP_002997865.1 similar to insertion sequence IS1239 transposase [Streptococcus pyogenes str. Manfredo] YP_002997866.1 SPOUT methyltransferase family protein; crystal structure shows homodimer; in Escherichia coli this protein methylates pseudouridine at position 1915 of the 23S ribosomal RNA YP_002997867.1 similar to endopeptidase DegP [Streptococcus pyogenes MGAS10750] YP_002997868.1 similar to chromosome partitioning protein [Streptococcus pyogenes MGAS6180]