-- dump date 20140620_081936 -- class Genbank::misc_feature -- table misc_feature_note -- id note 552526000001 chromosomal replication initiation protein; Reviewed; Region: dnaA; PRK00149 552526000002 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 552526000003 Walker A motif; other site 552526000004 ATP binding site [chemical binding]; other site 552526000005 Walker B motif; other site 552526000006 arginine finger; other site 552526000007 C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571 552526000008 DnaA box-binding interface [nucleotide binding]; other site 552526000009 DNA polymerase III subunit beta; Validated; Region: PRK05643 552526000010 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140 552526000011 putative DNA binding surface [nucleotide binding]; other site 552526000012 dimer interface [polypeptide binding]; other site 552526000013 beta-clamp/clamp loader binding surface; other site 552526000014 beta-clamp/translesion DNA polymerase binding surface; other site 552526000015 Bacterial protein of unknown function (DUF951); Region: DUF951; pfam06107 552526000016 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 552526000017 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 552526000018 non-specific DNA binding site [nucleotide binding]; other site 552526000019 salt bridge; other site 552526000020 sequence-specific DNA binding site [nucleotide binding]; other site 552526000021 GTP-binding protein YchF; Reviewed; Region: PRK09601 552526000022 YchF GTPase; Region: YchF; cd01900 552526000023 G1 box; other site 552526000024 GTP/Mg2+ binding site [chemical binding]; other site 552526000025 Switch I region; other site 552526000026 G2 box; other site 552526000027 Switch II region; other site 552526000028 G3 box; other site 552526000029 G4 box; other site 552526000030 G5 box; other site 552526000031 TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867 552526000032 Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462 552526000033 putative active site [active] 552526000034 catalytic residue [active] 552526000035 Transcription-repair coupling factor (superfamily II helicase) [DNA replication, recombination, and repair / Transcription]; Region: Mfd; COG1197 552526000036 CarD-like/TRCF domain; Region: CarD_TRCF; smart01058 552526000037 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 552526000038 ATP binding site [chemical binding]; other site 552526000039 putative Mg++ binding site [ion binding]; other site 552526000040 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 552526000041 nucleotide binding region [chemical binding]; other site 552526000042 ATP-binding site [chemical binding]; other site 552526000043 This domain is found in proteins necessary for strand-specific repair in DNA such as TRCF in Escherichia coli; Region: TRCF; smart00982 552526000044 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 552526000045 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 552526000046 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 552526000047 RNA binding surface [nucleotide binding]; other site 552526000048 Septum formation initiator [Cell division and chromosome partitioning]; Region: COG2919 552526000049 Septum formation initiator; Region: DivIC; pfam04977 552526000050 SH3-like domain; Region: SH3_8; pfam13457 552526000051 Beta-lactamase enzyme family; Region: Beta-lactamase2; pfam13354 552526000052 tRNA(Ile)-lysidine synthase MesJ [Cell cycle control, cell division, chromosome partitioning]; Region: MesJ; COG0037 552526000053 N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992 552526000054 Ligand Binding Site [chemical binding]; other site 552526000055 TilS substrate C-terminal domain; Region: TilS_C; smart00977 552526000056 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 552526000057 active site 552526000058 ATP-dependent Zn proteases [Posttranslational modification, protein turnover, chaperones]; Region: HflB; COG0465 552526000059 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 552526000060 Walker A motif; other site 552526000061 ATP binding site [chemical binding]; other site 552526000062 Walker B motif; other site 552526000063 arginine finger; other site 552526000064 Peptidase family M41; Region: Peptidase_M41; pfam01434 552526000065 amino acid transporter; Region: 2A0306; TIGR00909 552526000066 C-terminus of AA_permease; Region: AA_permease_C; pfam13906 552526000067 rod shape-determining protein MreC; Provisional; Region: PRK13922 552526000068 rod shape-determining protein MreC; Region: MreC; pfam04085 552526000069 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3883 552526000070 Surface antigen [General function prediction only]; Region: COG3942 552526000071 CHAP domain; Region: CHAP; pfam05257 552526000072 ribose-phosphate pyrophosphokinase; Provisional; Region: PRK02269 552526000073 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 552526000074 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 552526000075 active site 552526000076 Recombination protein O N terminal; Region: RecO_N; pfam11967 552526000077 DNA repair protein RecO; Region: reco; TIGR00613 552526000078 Recombination protein O C terminal; Region: RecO_C; pfam02565 552526000079 putative phosphate acyltransferase; Provisional; Region: PRK05331 552526000080 acyl carrier protein; Provisional; Region: PRK12449 552526000081 phosphoribosylaminoimidazole-succinocarboxamide synthase; Reviewed; Region: PRK09362 552526000082 bacterial and archaeal 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_PurC; cd01415 552526000083 ATP binding site [chemical binding]; other site 552526000084 active site 552526000085 substrate binding site [chemical binding]; other site 552526000086 phosphoribosylformylglycinamidine synthase, clade II; Region: FGAM-synthase; TIGR01857 552526000087 AIR (aminoimidazole ribonucleotide) synthase related protein. This family includes Hydrogen expression/formation protein HypE, AIR synthases, FGAM (formylglycinamidine ribonucleotide) synthase and Selenophosphate synthetase (SelD). The N-terminal domain...; Region: PurM-like; cl10019 552526000088 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203 552526000089 dimerization interface [polypeptide binding]; other site 552526000090 ATP binding site [chemical binding]; other site 552526000091 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat2; cd02204 552526000092 dimerization interface [polypeptide binding]; other site 552526000093 ATP binding site [chemical binding]; other site 552526000094 Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740 552526000095 putative active site [active] 552526000096 catalytic triad [active] 552526000097 amidophosphoribosyltransferase; Provisional; Region: PRK07272 552526000098 Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715 552526000099 active site 552526000100 tetramer interface [polypeptide binding]; other site 552526000101 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 552526000102 active site 552526000103 phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385 552526000104 PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196 552526000105 dimerization interface [polypeptide binding]; other site 552526000106 putative ATP binding site [chemical binding]; other site 552526000107 phosphoribosylglycinamide formyltransferase; Reviewed; Region: purN; PRK05647 552526000108 Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645 552526000109 active site 552526000110 substrate binding site [chemical binding]; other site 552526000111 cosubstrate binding site; other site 552526000112 catalytic site [active] 552526000113 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881 552526000114 Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal ATIC formylase domain that formylates...; Region: IMPCH; cd01421 552526000115 purine monophosphate binding site [chemical binding]; other site 552526000116 dimer interface [polypeptide binding]; other site 552526000117 putative catalytic residues [active] 552526000118 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; smart00798 552526000119 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; cl03362 552526000120 Surface antigen [General function prediction only]; Region: COG3942 552526000121 CHAP domain; Region: CHAP; pfam05257 552526000122 Bacterial SH3 domain; Region: SH3_5; pfam08460 552526000123 phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885 552526000124 Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844 552526000125 Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Region: GARS_A; pfam01071 552526000126 Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843 552526000127 Phosphoribosylcarboxyaminoimidazole (NCAIR) mutase [Nucleotide transport and metabolism]; Region: PurE; COG0041 552526000128 phosphoribosylaminoimidazole carboxylase ATPase subunit; Reviewed; Region: PRK06019 552526000129 ATP-grasp domain; Region: ATP-grasp; pfam02222 552526000130 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 552526000131 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 552526000132 non-specific DNA binding site [nucleotide binding]; other site 552526000133 salt bridge; other site 552526000134 sequence-specific DNA binding site [nucleotide binding]; other site 552526000135 Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080 552526000136 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 552526000137 Walker A motif; other site 552526000138 ATP binding site [chemical binding]; other site 552526000139 Walker B motif; other site 552526000140 arginine finger; other site 552526000141 Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491 552526000142 Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394 552526000143 Low molecular weight phosphatase family; Region: LMWPc; cd00115 552526000144 active site 552526000145 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4642 552526000146 bifunctional acetaldehyde-CoA/alcohol dehydrogenase; Provisional; Region: PRK13805 552526000147 Coenzyme A acylating aldehyde dehydrogenase (ACDH), ALDH family 20-like; Region: ALDH_F20_ACDH; cd07122 552526000148 putative catalytic cysteine [active] 552526000149 C-terminal alcohol dehydrogenase domain of the acetaldehyde dehydrogenase-alcohol dehydrogenase bifunctional two-domain protein (AAD); Region: AAD_C; cd08178 552526000150 putative active site [active] 552526000151 metal binding site [ion binding]; metal-binding site 552526000152 formaldehyde dehydrogenase (FDH)-like; Region: FDH_like_ADH2; cd08286 552526000153 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 552526000154 catalytic Zn binding site [ion binding]; other site 552526000155 structural Zn binding site [ion binding]; other site 552526000156 NAD(P) binding site [chemical binding]; other site 552526000157 ethanol-active dehydrogenase/acetaldehyde-active reductase; Provisional; Region: PRK09422 552526000158 Cinnamyl alcohol dehydrogenases (CAD); Region: CAD3; cd08297 552526000159 NAD binding site [chemical binding]; other site 552526000160 substrate binding site [chemical binding]; other site 552526000161 catalytic Zn binding site [ion binding]; other site 552526000162 tetramer interface [polypeptide binding]; other site 552526000163 structural Zn binding site [ion binding]; other site 552526000164 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 552526000165 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 552526000166 ATP-binding cassette domain of multidrug resistance protein-like transporters; Region: ABCC_MRP_Like; cd03228 552526000167 Walker A/P-loop; other site 552526000168 ATP binding site [chemical binding]; other site 552526000169 Q-loop/lid; other site 552526000170 ABC transporter signature motif; other site 552526000171 Walker B; other site 552526000172 D-loop; other site 552526000173 H-loop/switch region; other site 552526000174 ThiF family; Region: ThiF; pfam00899 552526000175 ATP binding site [chemical binding]; other site 552526000176 substrate interface [chemical binding]; other site 552526000177 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 552526000178 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 552526000179 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 552526000180 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 552526000181 non-specific DNA binding site [nucleotide binding]; other site 552526000182 salt bridge; other site 552526000183 sequence-specific DNA binding site [nucleotide binding]; other site 552526000184 transcriptional activator, Rgg/GadR/MutR family, C-terminal domain; Region: RGG_Cterm; TIGR01716 552526000185 Threonine synthase catalyzes the final step of threonine biosynthesis. The conversion of O-phosphohomoserine into threonine and inorganic phosphate is pyridoxal 5'-phosphate dependent. The Thr-synth_1 CD includes members from higher plants; Region: Thr-synth_2; cd01560 552526000186 Threonine synthase [Amino acid transport and metabolism]; Region: ThrC; COG0498 552526000187 pyridoxal 5'-phosphate binding site [chemical binding]; other site 552526000188 catalytic residue [active] 552526000189 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 552526000190 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 552526000191 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 552526000192 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 552526000193 30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596 552526000194 50S ribosomal protein L3; Validated; Region: rplC; PRK00001 552526000195 50S ribosomal protein L4; Provisional; Region: rplD; PRK05319 552526000196 50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738 552526000197 50S ribosomal protein L2; Validated; Region: rplB; PRK09374 552526000198 Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181 552526000199 Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947 552526000200 30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357 552526000201 Ribosomal protein L22/L17e. L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit. It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336 552526000202 putative translocon binding site; other site 552526000203 protein-rRNA interface [nucleotide binding]; other site 552526000204 30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310 552526000205 K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3 is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel. The KH...; Region: 30S_S3_KH; cd02412 552526000206 G-X-X-G motif; other site 552526000207 Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189 552526000208 Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433 552526000209 23S rRNA interface [nucleotide binding]; other site 552526000210 5S rRNA interface [nucleotide binding]; other site 552526000211 putative antibiotic binding site [chemical binding]; other site 552526000212 L25 interface [polypeptide binding]; other site 552526000213 L27 interface [polypeptide binding]; other site 552526000214 Ribosomal L29 protein/HIP. L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals. L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427 552526000215 23S rRNA interface [nucleotide binding]; other site 552526000216 putative translocon interaction site; other site 552526000217 signal recognition particle (SRP54) interaction site; other site 552526000218 L23 interface [polypeptide binding]; other site 552526000219 trigger factor interaction site; other site 552526000220 30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610 552526000221 50S ribosomal protein L14; Validated; Region: rplN; PRK05483 552526000222 50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004 552526000223 KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089 552526000224 RNA binding site [nucleotide binding]; other site 552526000225 50S ribosomal protein L5; Validated; Region: rplE; PRK00010 552526000226 Ribosomal protein L5; Region: Ribosomal_L5; pfam00281 552526000227 ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673 552526000228 30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08061 552526000229 30S ribosomal protein S8; Validated; Region: rpsH; PRK00136 552526000230 50S ribosomal protein L6; Validated; Region: rplF; PRK05498 552526000231 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 552526000232 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 552526000233 Ribosomal L18/L5e: L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432 552526000234 5S rRNA interface [nucleotide binding]; other site 552526000235 L27 interface [polypeptide binding]; other site 552526000236 23S rRNA interface [nucleotide binding]; other site 552526000237 L5 interface [polypeptide binding]; other site 552526000238 30S ribosomal protein S5; Validated; Region: rpsE; PRK00550 552526000239 Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333 552526000240 Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719 552526000241 Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins that...; Region: Ribosomal_L30; cd01658 552526000242 23S rRNA binding site [nucleotide binding]; other site 552526000243 50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592 552526000244 preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204 552526000245 SecY translocase; Region: SecY; pfam00344 552526000246 adenylate kinase; Reviewed; Region: adk; PRK00279 552526000247 Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428 552526000248 AMP-binding site [chemical binding]; other site 552526000249 ATP-AMP (Ap5A)-binding site [chemical binding]; other site 552526000250 S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451 552526000251 rRNA binding site [nucleotide binding]; other site 552526000252 predicted 30S ribosome binding site; other site 552526000253 Ribosomal protein L36; Region: Ribosomal_L36; pfam00444 552526000254 Ribosomal protein S13 [Translation, ribosomal structure and biogenesis]; Region: RpsM; COG0099 552526000255 30S ribosomal protein S13; Region: bact_S13; TIGR03631 552526000256 30S ribosomal protein S11; Validated; Region: PRK05309 552526000257 DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182 552526000258 N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928 552526000259 alphaNTD homodimer interface [polypeptide binding]; other site 552526000260 alphaNTD - beta interaction site [polypeptide binding]; other site 552526000261 alphaNTD - beta' interaction site [polypeptide binding]; other site 552526000262 Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118 552526000263 50S ribosomal protein L17; Validated; Region: rplQ; PRK05591 552526000264 Domain of unknown function (DUF4176); Region: DUF4176; pfam13780 552526000265 tyrosine recombinase XerC; Region: recomb_XerC; TIGR02224 552526000266 phiLC3 phage and phage-related integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes various bacterial (mainly gram positive) and phage integrases, including those similar to Lactococcus...; Region: INT_phiLC3_C; cd01189 552526000267 Int/Topo IB signature motif; other site 552526000268 Domain of unknown function (DUF3173); Region: DUF3173; pfam11372 552526000269 Replication initiation factor; Region: Rep_trans; pfam02486 552526000270 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 552526000271 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 552526000272 Transposase; Region: DDE_Tnp_ISL3; pfam01610 552526000273 Helix-turn-helix domain of transposase family ISL3; Region: HTH_Tnp_ISL3; pfam13542 552526000274 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cl17220 552526000275 H+ Antiporter protein; Region: 2A0121; TIGR00900 552526000276 Collagen triple helix repeat (20 copies); Region: Collagen; pfam01391 552526000277 Collagen triple helix repeat (20 copies); Region: Collagen; pfam01391 552526000278 Collagen triple helix repeat (20 copies); Region: Collagen; pfam01391 552526000279 Collagen triple helix repeat (20 copies); Region: Collagen; pfam01391 552526000280 Collagen triple helix repeat (20 copies); Region: Collagen; pfam01391 552526000281 Gram positive anchor; Region: Gram_pos_anchor; pfam00746 552526000282 Collagen triple helix repeat (20 copies); Region: Collagen; pfam01391 552526000283 LPXTG-motif cell wall anchor domain; Region: LPXTG_anchor; TIGR01167 552526000284 isopentenyl-diphosphate delta-isomerase, type 1; Region: IPP_isom_1; TIGR02150 552526000285 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_34; cd04693 552526000286 nudix motif; other site 552526000287 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: ipk; PRK00128 552526000288 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 552526000289 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 552526000290 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 552526000291 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 552526000292 putative Zn2+ binding site [ion binding]; other site 552526000293 putative DNA binding site [nucleotide binding]; other site 552526000294 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 552526000295 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 552526000296 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 552526000297 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 552526000298 ABC-ATPase subunit interface; other site 552526000299 dimer interface [polypeptide binding]; other site 552526000300 putative PBP binding regions; other site 552526000301 tyrosyl-tRNA synthetase; Validated; Region: PRK05912 552526000302 catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805 552526000303 active site 552526000304 HIGH motif; other site 552526000305 dimer interface [polypeptide binding]; other site 552526000306 KMSKS motif; other site 552526000307 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 552526000308 RNA binding surface [nucleotide binding]; other site 552526000309 Membrane carboxypeptidase (penicillin-binding protein) [Cell envelope biogenesis, outer membrane]; Region: MrcB; COG0744 552526000310 Transglycosylase; Region: Transgly; pfam00912 552526000311 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 552526000312 DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405 552526000313 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585 552526000314 RNA polymerase Rpb2, domain 2; Region: RNA_pol_Rpb2_2; pfam04561 552526000315 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585 552526000316 RNA polymerase beta subunit external 1 domain; Region: RNA_pol_Rpb2_45; pfam10385 552526000317 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 552526000318 RPB1 interaction site [polypeptide binding]; other site 552526000319 RPB10 interaction site [polypeptide binding]; other site 552526000320 RPB11 interaction site [polypeptide binding]; other site 552526000321 RPB3 interaction site [polypeptide binding]; other site 552526000322 RPB12 interaction site [polypeptide binding]; other site 552526000323 DNA-directed RNA polymerase subunit beta'; Provisional; Region: PRK00566 552526000324 RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997 552526000325 RNA polymerase I subunit A N-terminus; Region: RPOLA_N; smart00663 552526000326 RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983 552526000327 RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000 552526000328 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 552526000329 Rpb1 (beta') - Rpb6 (omega) interaction site [polypeptide binding]; other site 552526000330 Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site 552526000331 G-loop; other site 552526000332 DNA binding site [nucleotide binding] 552526000333 Acyltransferase family; Region: Acyl_transf_3; pfam01757 552526000334 Protein of unknown function (DUF1033); Region: DUF1033; pfam06279 552526000335 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4652 552526000336 Protein of unknown function (DUF1430); Region: DUF1430; pfam07242 552526000337 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 552526000338 putative bacteriocin export ABC transporter, lactococcin 972 group; Region: L_ocin_972_ABC; TIGR03608 552526000339 Walker A/P-loop; other site 552526000340 ATP binding site [chemical binding]; other site 552526000341 Q-loop/lid; other site 552526000342 ABC transporter signature motif; other site 552526000343 Walker B; other site 552526000344 D-loop; other site 552526000345 H-loop/switch region; other site 552526000346 Type II/IV secretion system protein; Region: T2SE; pfam00437 552526000347 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 552526000348 Walker A motif; other site 552526000349 ATP binding site [chemical binding]; other site 552526000350 Walker B motif; other site 552526000351 Type II secretory pathway, component PulF [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulF; COG1459 552526000352 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 552526000353 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 552526000354 Competence protein ComGC [Intracellular trafficking and secretion]; Region: ComGC; COG4537 552526000355 Competence protein ComGF [Intracellular trafficking and secretion]; Region: ComGF; COG4940 552526000356 putative transposase OrfB; Reviewed; Region: PHA02517 552526000357 HTH-like domain; Region: HTH_21; pfam13276 552526000358 Integrase core domain; Region: rve; pfam00665 552526000359 Integrase core domain; Region: rve_2; pfam13333 552526000360 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 552526000361 Helix-turn-helix domain; Region: HTH_28; pfam13518 552526000362 Adenine-specific DNA methylase [DNA replication, recombination, and repair]; Region: COG0827 552526000363 Methyltransferase domain; Region: Methyltransf_26; pfam13659 552526000364 acetate kinase A/propionate kinase 2; Reviewed; Region: PRK00180 552526000365 propionate/acetate kinase; Provisional; Region: PRK12379 552526000366 Transcriptional antiterminator [Transcription]; Region: BglG; COG3711 552526000367 PRD domain; Region: PRD; pfam00874 552526000368 PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568 552526000369 active site 552526000370 P-loop; other site 552526000371 phosphorylation site [posttranslational modification] 552526000372 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 552526000373 active site 552526000374 phosphorylation site [posttranslational modification] 552526000375 PTS_IIB_ascorbate: subunit IIB of enzyme II (EII) of the L-ascorbate-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is an L-ascorbate-specific permease with two cytoplasmic subunits (IIA and IIB) and a...; Region: PTS_IIB_ascorbate; cd05563 552526000376 active site 552526000377 P-loop; other site 552526000378 phosphorylation site [posttranslational modification] 552526000379 PTS system ascorbate-specific transporter subunit IIC; Reviewed; Region: ulaA; PRK09410 552526000380 Predicted metalloendopeptidase [Posttranslational modification, protein turnover, chaperones]; Region: PepO; COG3590 552526000381 Peptidase family M13 includes neprilysin, endothelin-converting enzyme I; Region: M13; cd08662 552526000382 active site 552526000383 Zn binding site [ion binding]; other site 552526000384 elongation factor Ts; Provisional; Region: tsf; PRK09377 552526000385 UBA/TS-N domain; Region: UBA; pfam00627 552526000386 Elongation factor TS; Region: EF_TS; pfam00889 552526000387 Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425 552526000388 rRNA interaction site [nucleotide binding]; other site 552526000389 S8 interaction site; other site 552526000390 putative laminin-1 binding site; other site 552526000391 peroxiredoxin; Region: AhpC; TIGR03137 552526000392 Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015 552526000393 dimer interface [polypeptide binding]; other site 552526000394 decamer (pentamer of dimers) interface [polypeptide binding]; other site 552526000395 catalytic triad [active] 552526000396 peroxidatic and resolving cysteines [active] 552526000397 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 552526000398 DNA-binding site [nucleotide binding]; DNA binding site 552526000399 RNA-binding motif; other site 552526000400 Transcriptional repressor of class III stress genes [Transcription]; Region: CtsR; COG4463 552526000401 ATP-binding subunits of Clp protease and DnaK/DnaJ chaperones [Posttranslational modification, protein turnover, chaperones]; Region: clpA; COG0542 552526000402 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 552526000403 Walker A motif; other site 552526000404 ATP binding site [chemical binding]; other site 552526000405 Walker B motif; other site 552526000406 arginine finger; other site 552526000407 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 552526000408 Walker A motif; other site 552526000409 ATP binding site [chemical binding]; other site 552526000410 Walker B motif; other site 552526000411 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 552526000412 Lipase. Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is "interfacial activation", the process of...; Region: Lipase; cl14883 552526000413 nucleophilic elbow; other site 552526000414 catalytic triad; other site 552526000415 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 552526000416 oligomerisation interface [polypeptide binding]; other site 552526000417 mobile loop; other site 552526000418 roof hairpin; other site 552526000419 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 552526000420 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 552526000421 ring oligomerisation interface [polypeptide binding]; other site 552526000422 ATP/Mg binding site [chemical binding]; other site 552526000423 stacking interactions; other site 552526000424 hinge regions; other site 552526000425 MutT homolog-1 (MTH1) is a member of the Nudix hydrolase superfamily. MTH1, the mammalian counterpart of MutT, hydrolyzes oxidized purine nucleoside triphosphates, such as 8-oxo-dGTP and 2-hydroxy-ATP, to monophosphates, thereby preventing the...; Region: MTH1; cd03427 552526000426 putative active site [active] 552526000427 nucleotide binding site [chemical binding]; other site 552526000428 nudix motif; other site 552526000429 putative metal binding site [ion binding]; other site 552526000430 circular bacteriocin, circularin A/uberolysin family; Region: circ_ocin_uber; TIGR03651 552526000431 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 552526000432 putative bacteriocin export ABC transporter, lactococcin 972 group; Region: L_ocin_972_ABC; TIGR03608 552526000433 Walker A/P-loop; other site 552526000434 ATP binding site [chemical binding]; other site 552526000435 Q-loop/lid; other site 552526000436 ABC transporter signature motif; other site 552526000437 Walker B; other site 552526000438 D-loop; other site 552526000439 H-loop/switch region; other site 552526000440 Predicted membrane protein [Function unknown]; Region: COG4640 552526000441 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 552526000442 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 552526000443 active site 552526000444 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 552526000445 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 552526000446 homotrimer interaction site [polypeptide binding]; other site 552526000447 putative active site [active] 552526000448 Membrane carboxypeptidase (penicillin-binding protein) [Cell envelope biogenesis, outer membrane]; Region: MrcB; COG0744 552526000449 Transglycosylase; Region: Transgly; pfam00912 552526000450 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 552526000451 Preprotein translocase subunit SecE [Intracellular trafficking and secretion]; Region: SecE; COG0690 552526000452 transcription antitermination protein NusG; Validated; Region: nusG; PRK05609 552526000453 Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891 552526000454 putative homodimer interface [polypeptide binding]; other site 552526000455 NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091 552526000456 heterodimer interface [polypeptide binding]; other site 552526000457 homodimer interface [polypeptide binding]; other site 552526000458 Collagen triple helix repeat (20 copies); Region: Collagen; pfam01391 552526000459 Collagen triple helix repeat (20 copies); Region: Collagen; pfam01391 552526000460 M protein trans-acting positive regulator (MGA) HTH domain; Region: HTH_Mga; pfam08280 552526000461 Mga helix-turn-helix domain; Region: Mga; pfam05043 552526000462 M protein trans-acting positive regulator (MGA) PRD domain; Region: PRD_Mga; pfam08270 552526000463 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 552526000464 leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390 552526000465 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 552526000466 HIGH motif; other site 552526000467 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 552526000468 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 552526000469 active site 552526000470 KMSKS motif; other site 552526000471 Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958 552526000472 tRNA binding surface [nucleotide binding]; other site 552526000473 PTS system ascorbate-specific transporter subunit IIC; Reviewed; Region: PRK12997 552526000474 PTS_IIB_ascorbate: subunit IIB of enzyme II (EII) of the L-ascorbate-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is an L-ascorbate-specific permease with two cytoplasmic subunits (IIA and IIB) and a...; Region: PTS_IIB_ascorbate; cd05563 552526000475 active site 552526000476 P-loop; other site 552526000477 phosphorylation site [posttranslational modification] 552526000478 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 552526000479 active site 552526000480 phosphorylation site [posttranslational modification] 552526000481 3-Keto-L-gulonate 6-phosphate decarboxylase (KGPDC) and D-arabino-3-hexulose-6-phosphate synthase (HPS). KGPDC catalyzes the formation of L-xylulose 5-phosphate and carbon dioxide from 3-keto-L-gulonate 6-phosphate as part of the anaerobic pathway for...; Region: KGPDC_HPS; cd04726 552526000482 active site 552526000483 dimer interface [polypeptide binding]; other site 552526000484 magnesium binding site [ion binding]; other site 552526000485 putative L-xylulose 5-phosphate 3-epimerase; Reviewed; Region: PRK13210 552526000486 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cd00019 552526000487 AP (apurinic/apyrimidinic) site pocket; other site 552526000488 DNA interaction; other site 552526000489 Metal-binding active site; metal-binding site 552526000490 L-ribulose-5-phosphate 4-epimerase; Provisional; Region: araD; PRK13145 552526000491 L-ribulose-5-phosphate 4-epimerase; Reviewed; Region: araD; PRK08193 552526000492 intersubunit interface [polypeptide binding]; other site 552526000493 active site 552526000494 Zn2+ binding site [ion binding]; other site 552526000495 Transcriptional antiterminator [Transcription]; Region: BglG; COG3711 552526000496 PRD domain; Region: PRD; pfam00874 552526000497 PRD domain; Region: PRD; pfam00874 552526000498 PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568 552526000499 active site 552526000500 P-loop; other site 552526000501 phosphorylation site [posttranslational modification] 552526000502 putative L-ascorbate 6-phosphate lactonase; Provisional; Region: PRK11709 552526000503 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 552526000504 ABC-type proline/glycine betaine transport system, ATPase component [Amino acid transport and metabolism]; Region: ProV; COG4175 552526000505 ATP-binding cassette domain of the osmoprotectant proline/glycine betaine uptake system; Region: ABC_Pro_Gly_Betaine; cd03294 552526000506 Walker A/P-loop; other site 552526000507 ATP binding site [chemical binding]; other site 552526000508 Q-loop/lid; other site 552526000509 ABC transporter signature motif; other site 552526000510 Walker B; other site 552526000511 D-loop; other site 552526000512 H-loop/switch region; other site 552526000513 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 552526000514 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 552526000515 dimer interface [polypeptide binding]; other site 552526000516 conserved gate region; other site 552526000517 putative PBP binding loops; other site 552526000518 ABC-ATPase subunit interface; other site 552526000519 ABC-type proline/glycine betaine transport systems, periplasmic components [Amino acid transport and metabolism]; Region: ProX; COG2113 552526000520 Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069 552526000521 Transposase [DNA replication, recombination, and repair]; Region: COG5421 552526000522 Transposase [DNA replication, recombination, and repair]; Region: COG5421 552526000523 DNA polymerase I; Provisional; Region: PRK05755 552526000524 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 552526000525 active site 552526000526 metal binding site 1 [ion binding]; metal-binding site 552526000527 putative 5' ssDNA interaction site; other site 552526000528 metal binding site 3; metal-binding site 552526000529 metal binding site 2 [ion binding]; metal-binding site 552526000530 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 552526000531 putative DNA binding site [nucleotide binding]; other site 552526000532 putative metal binding site [ion binding]; other site 552526000533 inactive DEDDy 3'-5' exonuclease domain of Bacillus stearothermophilus DNA polymerase I and similar family-A DNA polymerases; Region: DNA_polA_I_Bacillus_like_exo; cd06140 552526000534 Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637 552526000535 active site 552526000536 DNA binding site [nucleotide binding] 552526000537 catalytic site [active] 552526000538 Predicted CoA-binding protein [General function prediction only]; Region: COG1832 552526000539 ferric uptake regulator; Provisional; Region: fur; PRK09462 552526000540 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 552526000541 metal binding site 2 [ion binding]; metal-binding site 552526000542 putative DNA binding helix; other site 552526000543 metal binding site 1 [ion binding]; metal-binding site 552526000544 dimer interface [polypeptide binding]; other site 552526000545 structural Zn2+ binding site [ion binding]; other site 552526000546 YSIRK type signal peptide; Region: YSIRK_signal; pfam04650 552526000547 NPCBM/NEW2 domain; Region: NPCBM; pfam08305 552526000548 F5/8 type C domain; Region: F5_F8_type_C; pfam00754 552526000549 Protein of unknown function (DUF975); Region: DUF975; pfam06161 552526000550 queuine tRNA-ribosyltransferase; Provisional; Region: tgt; PRK00112 552526000551 Queuine/archaeosine tRNA-ribosyltransferase [Translation, ribosomal structure and biogenesis]; Region: Tgt; COG0343 552526000552 Gram positive anchor; Region: Gram_pos_anchor; pfam00746 552526000553 Zinc finger domain containing protein (CHY type) [Function unknown]; Region: COG4357 552526000554 CHY zinc finger; Region: zf-CHY; pfam05495 552526000555 Uncharacterized conserved protein [General function prediction only]; Region: BioY; COG1268 552526000556 Metal-dependent hydrolases of the beta-lactamase superfamily III [General function prediction only]; Region: ElaC; COG1234 552526000557 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 552526000558 nucleoside/Zn binding site; other site 552526000559 dimer interface [polypeptide binding]; other site 552526000560 catalytic motif [active] 552526000561 Uncharacterized protein involved in cytokinesis, contains TGc (transglutaminase/protease-like) domain [Cell division and chromosome partitioning]; Region: CYK3; COG5279 552526000562 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 552526000563 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 552526000564 Helix-turn-helix domain; Region: HTH_38; pfam13936 552526000565 Integrase core domain; Region: rve; pfam00665 552526000566 Glycosyltransferases, probably involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: COG1215 552526000567 CESA_like is the cellulose synthase superfamily; Region: CESA_like; cd06423 552526000568 Glycosyl transferase family group 2; Region: Glyco_trans_2_3; pfam13632 552526000569 DXD motif; other site 552526000570 UDP-glucose 6-dehydrogenase; Provisional; Region: PRK15057 552526000571 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 552526000572 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 552526000573 UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984 552526000574 Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541 552526000575 dTDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: RfbA; COG1209 552526000576 active site 552526000577 tetramer interface; other site 552526000578 bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase; Provisional; Region: glmU; PRK14354 552526000579 N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540 552526000580 Substrate binding site; other site 552526000581 Mg++ binding site; other site 552526000582 N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353 552526000583 active site 552526000584 substrate binding site [chemical binding]; other site 552526000585 CoA binding site [chemical binding]; other site 552526000586 glucose-6-phosphate isomerase; Provisional; Region: pgi; PRK14097 552526000587 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015 552526000588 active site 552526000589 dimer interface [polypeptide binding]; other site 552526000590 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016 552526000591 dimer interface [polypeptide binding]; other site 552526000592 active site 552526000593 sorbitol-6-phosphate 2-dehydrogenase; Provisional; Region: PRK06171 552526000594 classical (c) SDRs; Region: SDR_c; cd05233 552526000595 NAD(P) binding site [chemical binding]; other site 552526000596 active site 552526000597 Transcriptional antiterminator [Transcription]; Region: BglG; COG3711 552526000598 HTH domain; Region: HTH_11; pfam08279 552526000599 PRD domain; Region: PRD; pfam00874 552526000600 PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568 552526000601 active site 552526000602 P-loop; other site 552526000603 phosphorylation site [posttranslational modification] 552526000604 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 552526000605 active site 552526000606 phosphorylation site [posttranslational modification] 552526000607 Glucitol operon activator protein (GutM); Region: GutM; pfam06923 552526000608 PTS system enzyme II sorbitol-specific factor; Region: EII-GUT; pfam03608 552526000609 Sorbitol phosphotransferase enzyme II N-terminus; Region: EIIBC-GUT_N; pfam03612 552526000610 PTS system, glucitol/sorbitol-specific, IIBC component; Region: EIIBC-GUT; TIGR00825 552526000611 Sorbitol phosphotransferase enzyme II C-terminus; Region: EIIBC-GUT_C; pfam07663 552526000612 PTS system glucitol/sorbitol-specific IIA component; Region: PTSIIA_gutA; pfam03829 552526000613 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3666 552526000614 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 552526000615 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 552526000616 AAA domain; Region: AAA_21; pfam13304 552526000617 RloB-like protein; Region: RloB; pfam13707 552526000618 Gram positive anchor; Region: Gram_pos_anchor; pfam00746 552526000619 5-formyltetrahydrofolate cyclo-ligase family; Region: 5-FTHF_cyc-lig; pfam01812 552526000620 5-formyltetrahydrofolate cyclo-ligase [Coenzyme metabolism]; Region: COG0212; cl00360 552526000621 Rhomboid family; Region: Rhomboid; pfam01694 552526000622 Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541 552526000623 dTDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: RfbA; COG1209 552526000624 active site 552526000625 tetramer interface; other site 552526000626 NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094 552526000627 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 552526000628 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479 552526000629 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 552526000630 MarR family; Region: MarR_2; pfam12802 552526000631 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 552526000632 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 552526000633 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 552526000634 Walker A/P-loop; other site 552526000635 ATP binding site [chemical binding]; other site 552526000636 Q-loop/lid; other site 552526000637 ABC transporter signature motif; other site 552526000638 Walker B; other site 552526000639 D-loop; other site 552526000640 H-loop/switch region; other site 552526000641 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 552526000642 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 552526000643 ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251 552526000644 Walker A/P-loop; other site 552526000645 ATP binding site [chemical binding]; other site 552526000646 Q-loop/lid; other site 552526000647 ABC transporter signature motif; other site 552526000648 Walker B; other site 552526000649 D-loop; other site 552526000650 H-loop/switch region; other site 552526000651 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1636 552526000652 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 552526000653 trimer interface [polypeptide binding]; other site 552526000654 active site 552526000655 DNA repair protein RadA; Provisional; Region: PRK11823 552526000656 Sms (bacterial radA) DNA repair protein. This protein is not related to archael radA any more than is to other RecA-like NTPases. Sms has a role in recombination and recombinational repair and is responsible for the stabilization or processing of...; Region: Sms; cd01121 552526000657 Walker A motif/ATP binding site; other site 552526000658 ATP binding site [chemical binding]; other site 552526000659 Walker B motif; other site 552526000660 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 552526000661 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeD; cd03379 552526000662 active site clefts [active] 552526000663 zinc binding site [ion binding]; other site 552526000664 dimer interface [polypeptide binding]; other site 552526000665 Uncharacterized conserved protein [Function unknown]; Region: COG2013 552526000666 glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406 552526000667 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 552526000668 active site 552526000669 HIGH motif; other site 552526000670 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 552526000671 active site 552526000672 KMSKS motif; other site 552526000673 glucans biosynthesis protein; Provisional; Region: opgC; PRK03854 552526000674 Predicted signal transduction protein with a C-terminal ATPase domain [Signal transduction mechanisms]; Region: COG2972 552526000675 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 552526000676 ATP binding site [chemical binding]; other site 552526000677 Mg2+ binding site [ion binding]; other site 552526000678 G-X-G motif; other site 552526000679 Predicted signal transduction protein with a C-terminal ATPase domain [Signal transduction mechanisms]; Region: COG2972 552526000680 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 552526000681 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 552526000682 active site 552526000683 phosphorylation site [posttranslational modification] 552526000684 intermolecular recognition site; other site 552526000685 dimerization interface [polypeptide binding]; other site 552526000686 LytTr DNA-binding domain; Region: LytTR; pfam04397 552526000687 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 552526000688 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 552526000689 Walker A/P-loop; other site 552526000690 ATP binding site [chemical binding]; other site 552526000691 Q-loop/lid; other site 552526000692 ABC transporter signature motif; other site 552526000693 Walker B; other site 552526000694 D-loop; other site 552526000695 H-loop/switch region; other site 552526000696 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 552526000697 ribonuclease P; Reviewed; Region: rnpA; PRK00499 552526000698 Preprotein translocase subunit YidC [Intracellular trafficking and secretion]; Region: YidC; COG0706 552526000699 membrane protein insertase, YidC/Oxa1 family, C-terminal domain; Region: yidC_oxa1_cterm; TIGR03592 552526000700 Predicted RNA-binding protein [General function prediction only]; Region: Jag; COG1847 552526000701 jag_K homology RNA-binding domain. The KH domain is found in proteins homologous to the Bacillus subtilis protein Jag, which is associated with SpoIIIJ and is necessary for the third stage of sporulation. The KH motif is a beta-alpha-alpha-beta-beta...; Region: jag_KH; cd02414 552526000702 G-X-X-G motif; other site 552526000703 R3H domain found in proteins homologous to Bacillus subtilus Jag, which is associated with SpoIIIJ. SpoIIIJ is necessary for the third stage of sporulation. The name of the R3H domain comes from the characteristic spacing of the most conserved arginine...; Region: R3H_jag; cd02644 552526000704 RxxxH motif; other site 552526000705 N-acetylmannosamine-6-phosphate epimerase (NanE) converts N-acetylmannosamine-6-phosphate to N-acetylglucosamine-6-phosphate. This reaction is part of the pathway that allows the usage of sialic acid as a carbohydrate source. Sialic acids are a family of...; Region: NanE; cd04729 552526000706 N-acetylmannosamine-6-phosphate 2-epimerase; Provisional; Region: PRK01130 552526000707 putative active site cavity [active] 552526000708 PTS system, glucose-specific IIBC component; Region: PTS-II-BC-glcB; TIGR02002 552526000709 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 552526000710 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cl00164 552526000711 active site turn [active] 552526000712 phosphorylation site [posttranslational modification] 552526000713 Phosphotransferase system IIA components [Carbohydrate transport and metabolism]; Region: NagE; COG2190 552526000714 HPr interaction site; other site 552526000715 glycerol kinase (GK) interaction site [polypeptide binding]; other site 552526000716 active site 552526000717 phosphorylation site [posttranslational modification] 552526000718 50S ribosomal protein L34; Reviewed; Region: rpmH; PRK00399 552526000719 N-acetylmannosamine-6-phosphate epimerase (NanE) converts N-acetylmannosamine-6-phosphate to N-acetylglucosamine-6-phosphate. This reaction is part of the pathway that allows the usage of sialic acid as a carbohydrate source. Sialic acids are a family of...; Region: NanE; cd04729 552526000720 N-acetylmannosamine-6-phosphate 2-epimerase; Provisional; Region: PRK01130 552526000721 putative active site cavity [active] 552526000722 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 552526000723 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 552526000724 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 552526000725 dimer interface [polypeptide binding]; other site 552526000726 conserved gate region; other site 552526000727 putative PBP binding loops; other site 552526000728 ABC-ATPase subunit interface; other site 552526000729 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 552526000730 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 552526000731 dimer interface [polypeptide binding]; other site 552526000732 conserved gate region; other site 552526000733 putative PBP binding loops; other site 552526000734 ABC-ATPase subunit interface; other site 552526000735 Domain of unknown function (DUF386); Region: DUF386; cl01047 552526000736 Protein of unknown function, DUF624; Region: DUF624; pfam04854 552526000737 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 552526000738 Class I aldolases; Region: Aldolase_Class_I; cl17187 552526000739 catalytic residue [active] 552526000740 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 552526000741 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 552526000742 nucleotide binding site [chemical binding]; other site 552526000743 Acetyl xylan esterase (AXE1); Region: AXE1; pfam05448 552526000744 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 552526000745 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 552526000746 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 552526000747 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 552526000748 putative active site [active] 552526000749 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 552526000750 active site 552526000751 ribonuclease M5; Region: 5S_RNA_mat_M5; TIGR00334 552526000752 TOPRIM_ RNase M5_like: The topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain found in Ribonuclease M5: (RNase M5) and other small primase-like proteins from bacteria and archaea. RNase M5 catalyzes the maturation of 5S rRNA in low...; Region: TOPRIM_RNase_M5_like; cd01027 552526000753 putative active site [active] 552526000754 putative metal binding site [ion binding]; other site 552526000755 Domain of unknown function (DUF4093); Region: DUF4093; pfam13331 552526000756 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 552526000757 catalytic residues [active] 552526000758 16S ribosomal RNA methyltransferase KsgA/Dim1 family protein; Reviewed; Region: ksgA; PRK00274 552526000759 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 552526000760 S-adenosylmethionine binding site [chemical binding]; other site 552526000761 GTPase RsgA; Reviewed; Region: PRK00098 552526000762 S1_YloQ_GTPase: YloQ GTase family (also known as YjeQ and CpgA), S1-like RNA-binding domain. Proteins in the YloQ GTase family bind the ribosome and have GTPase activity. The precise role of this family is unknown. The protein structure is composed of...; Region: S1_YloQ_GTPase; cd04466 552526000763 RNA binding site [nucleotide binding]; other site 552526000764 homodimer interface [polypeptide binding]; other site 552526000765 Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854 552526000766 GTPase/Zn-binding domain interface [polypeptide binding]; other site 552526000767 GTP/Mg2+ binding site [chemical binding]; other site 552526000768 G4 box; other site 552526000769 G1 box; other site 552526000770 Switch I region; other site 552526000771 G2 box; other site 552526000772 G3 box; other site 552526000773 Switch II region; other site 552526000774 Pentose-5-phosphate-3-epimerase [Carbohydrate transport and metabolism]; Region: Rpe; COG0036 552526000775 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 552526000776 substrate binding site [chemical binding]; other site 552526000777 hexamer interface [polypeptide binding]; other site 552526000778 metal binding site [ion binding]; metal-binding site 552526000779 Thiamine pyrophosphokinase [Coenzyme metabolism]; Region: THI80; COG1564 552526000780 Thiamine pyrophosphokinase; Region: TPK; cd07995 552526000781 active site 552526000782 dimerization interface [polypeptide binding]; other site 552526000783 thiamine binding site [chemical binding]; other site 552526000784 Predicted nuclease of restriction endonuclease-like fold, RmuC family [General function prediction only]; Region: COG1322 552526000785 RmuC family; Region: RmuC; pfam02646 552526000786 Predicted HD-superfamily hydrolase [General function prediction only]; Region: COG3481 552526000787 YhaM_OBF_like: A subfamily of OB folds similar to that found in Bacillus subtilis YhaM and Staphylococcus aureus cmp-binding factor-1 (SaCBF1). Both these proteins are 3'-to-5'exoribonucleases. YhaM requires Mn2+ or Co2+ for activity and is...; Region: YhaM_OBF_like; cd04492 552526000788 generic binding surface II; other site 552526000789 generic binding surface I; other site 552526000790 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 552526000791 Zn2+ binding site [ion binding]; other site 552526000792 Mg2+ binding site [ion binding]; other site 552526000793 pur operon repressor; Provisional; Region: PRK09213 552526000794 Bacterial purine repressor, N-terminal; Region: PuR_N; pfam09182 552526000795 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 552526000796 active site 552526000797 SEC10/PgrA surface exclusion domain; Region: Surf_Exclu_PgrA; TIGR04320 552526000798 S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368 552526000799 S17 interaction site [polypeptide binding]; other site 552526000800 S8 interaction site; other site 552526000801 16S rRNA interaction site [nucleotide binding]; other site 552526000802 streptomycin interaction site [chemical binding]; other site 552526000803 23S rRNA interaction site [nucleotide binding]; other site 552526000804 aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site 552526000805 30S ribosomal protein S7; Validated; Region: PRK05302 552526000806 elongation factor G; Reviewed; Region: PRK00007 552526000807 Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886 552526000808 G1 box; other site 552526000809 putative GEF interaction site [polypeptide binding]; other site 552526000810 GTP/Mg2+ binding site [chemical binding]; other site 552526000811 Switch I region; other site 552526000812 G2 box; other site 552526000813 G3 box; other site 552526000814 Switch II region; other site 552526000815 G4 box; other site 552526000816 G5 box; other site 552526000817 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 552526000818 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 552526000819 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 552526000820 Glyceraldehyde-3-phosphate dehydrogenase/erythrose-4-phosphate dehydrogenase [Carbohydrate transport and metabolism]; Region: GapA; COG0057 552526000821 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846 552526000822 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 552526000823 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 552526000824 active site 552526000825 motif I; other site 552526000826 motif II; other site 552526000827 phosphoglycerate kinase; Provisional; Region: pgk; PRK00073 552526000828 Phosphoglycerate kinase; Region: PGK; pfam00162 552526000829 substrate binding site [chemical binding]; other site 552526000830 hinge regions; other site 552526000831 ADP binding site [chemical binding]; other site 552526000832 catalytic site [active] 552526000833 Predicted membrane protein [Function unknown]; Region: COG4129 552526000834 Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174 552526000835 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 552526000836 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 552526000837 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 552526000838 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 552526000839 peptide binding site [polypeptide binding]; other site 552526000840 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 552526000841 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 552526000842 dimer interface [polypeptide binding]; other site 552526000843 conserved gate region; other site 552526000844 putative PBP binding loops; other site 552526000845 ABC-ATPase subunit interface; other site 552526000846 oligopeptide ABC transporter permease OppC; Provisional; Region: PRK15406 552526000847 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 552526000848 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 552526000849 dimer interface [polypeptide binding]; other site 552526000850 conserved gate region; other site 552526000851 putative PBP binding loops; other site 552526000852 ABC-ATPase subunit interface; other site 552526000853 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 552526000854 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 552526000855 Walker A/P-loop; other site 552526000856 ATP binding site [chemical binding]; other site 552526000857 Q-loop/lid; other site 552526000858 ABC transporter signature motif; other site 552526000859 Walker B; other site 552526000860 D-loop; other site 552526000861 H-loop/switch region; other site 552526000862 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 552526000863 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 552526000864 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 552526000865 Walker A/P-loop; other site 552526000866 ATP binding site [chemical binding]; other site 552526000867 Q-loop/lid; other site 552526000868 ABC transporter signature motif; other site 552526000869 Walker B; other site 552526000870 D-loop; other site 552526000871 H-loop/switch region; other site 552526000872 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352 552526000873 mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595 552526000874 Metallo-beta-lactamase superfamily; Region: Lactamase_B; pfam00753 552526000875 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 552526000876 hypothetical protein; Provisional; Region: PRK13667 552526000877 tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725 552526000878 Glycoprotease family; Region: Peptidase_M22; pfam00814 552526000879 ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575 552526000880 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 552526000881 Coenzyme A binding pocket [chemical binding]; other site 552526000882 UGMP family protein; Validated; Region: PRK09604 552526000883 Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214; cl17884 552526000884 Carbamoyltransferase; Region: CmcH_NodU; pfam02543 552526000885 Uncharacterized conserved protein [Function unknown]; Region: COG1434 552526000886 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 552526000887 putative active site [active] 552526000888 30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08881 552526000889 HI0933-like protein; Region: HI0933_like; pfam03486 552526000890 Chromate resistance exported protein; Region: Chrome_Resist; cl01744 552526000891 HTH domain; Region: HTH_11; cl17392 552526000892 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 552526000893 active site 552526000894 catalytic site [active] 552526000895 substrate binding site [chemical binding]; other site 552526000896 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 552526000897 Helix-Turn-Helix DNA binding domain of the transcription regulators TipAL, Mta, and SkgA; Region: HTH_TipAL-Mta; cd01106 552526000898 DNA binding residues [nucleotide binding] 552526000899 dimer interface [polypeptide binding]; other site 552526000900 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 552526000901 Helix-turn-helix domain; Region: HTH_28; pfam13518 552526000902 putative transposase OrfB; Reviewed; Region: PHA02517 552526000903 HTH-like domain; Region: HTH_21; pfam13276 552526000904 Integrase core domain; Region: rve; pfam00665 552526000905 Integrase core domain; Region: rve_2; pfam13333 552526000906 hypothetical protein; Validated; Region: PRK00153 552526000907 integrase; Provisional; Region: int; PHA02601 552526000908 phiLC3 phage and phage-related integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes various bacterial (mainly gram positive) and phage integrases, including those similar to Lactococcus...; Region: INT_phiLC3_C; cd01189 552526000909 Int/Topo IB signature motif; other site 552526000910 Domain of unknown function (DUF3173); Region: DUF3173; pfam11372 552526000911 Replication initiation factor; Region: Rep_trans; pfam02486 552526000912 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 552526000913 sequence-specific DNA binding site [nucleotide binding]; other site 552526000914 salt bridge; other site 552526000915 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 552526000916 non-specific DNA binding site [nucleotide binding]; other site 552526000917 salt bridge; other site 552526000918 sequence-specific DNA binding site [nucleotide binding]; other site 552526000919 Domain of unknown function (DUF955); Region: DUF955; cl01076 552526000920 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 552526000921 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 552526000922 active site 552526000923 phosphorylation site [posttranslational modification] 552526000924 intermolecular recognition site; other site 552526000925 dimerization interface [polypeptide binding]; other site 552526000926 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 552526000927 DNA binding site [nucleotide binding] 552526000928 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 552526000929 HAMP domain; Region: HAMP; pfam00672 552526000930 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 552526000931 dimer interface [polypeptide binding]; other site 552526000932 phosphorylation site [posttranslational modification] 552526000933 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 552526000934 ATP binding site [chemical binding]; other site 552526000935 Mg2+ binding site [ion binding]; other site 552526000936 G-X-G motif; other site 552526000937 Fibronectin-binding protein signal sequence; Region: Fb_signal; pfam08341 552526000938 TQXA domain; Region: TQXA_dom; TIGR03934 552526000939 Fibronectin binding repeat; Region: Fn_bind; pfam02986 552526000940 Fibronectin binding repeat; Region: Fn_bind; pfam02986 552526000941 Fibronectin binding repeat; Region: Fn_bind; pfam02986 552526000942 Fibronectin binding repeat; Region: Fn_bind; pfam02986 552526000943 M protein trans-acting positive regulator (MGA) HTH domain; Region: HTH_Mga; pfam08280 552526000944 Mga helix-turn-helix domain; Region: Mga; pfam05043 552526000945 M protein trans-acting positive regulator (MGA) PRD domain; Region: PRD_Mga; pfam08270 552526000946 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 552526000947 sequence-specific DNA binding site [nucleotide binding]; other site 552526000948 salt bridge; other site 552526000949 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 552526000950 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 552526000951 non-specific DNA binding site [nucleotide binding]; other site 552526000952 salt bridge; other site 552526000953 sequence-specific DNA binding site [nucleotide binding]; other site 552526000954 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381 552526000955 x-prolyl-dipeptidyl aminopeptidase; Provisional; Region: PRK05371 552526000956 X-Prolyl dipeptidyl aminopeptidase PepX, N-terminal; Region: PepX_N; pfam09168 552526000957 X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain; Region: PepX_C; pfam08530 552526000958 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 552526000959 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cl17320 552526000960 non-specific DNA interactions [nucleotide binding]; other site 552526000961 DNA binding site [nucleotide binding] 552526000962 sequence specific DNA binding site [nucleotide binding]; other site 552526000963 putative cAMP binding site [chemical binding]; other site 552526000964 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 552526000965 Major Facilitator Superfamily; Region: MFS_1; pfam07690 552526000966 putative substrate translocation pore; other site 552526000967 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 552526000968 Ligand Binding Site [chemical binding]; other site 552526000969 Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cd00333 552526000970 amphipathic channel; other site 552526000971 Asn-Pro-Ala signature motifs; other site 552526000972 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 552526000973 active site 552526000974 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 552526000975 active site 552526000976 Beta-lactamase; Region: Beta-lactamase; pfam00144 552526000977 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 552526000978 formate acetyltransferase 1; Region: pyr_form_ly_1; TIGR01255 552526000979 Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939 552526000980 DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586 552526000981 active site 552526000982 DNA polymerase IV; Validated; Region: PRK02406 552526000983 DNA binding site [nucleotide binding] 552526000984 helicase, putative, RecD/TraA family; Region: recD_rel; TIGR01448 552526000985 H3TH domains of structure-specific 5' nucleases (or flap endonuclease-1-like) involved in DNA replication, repair, and recombination; Region: H3TH_StructSpec-5'-nucleases; cl14815 552526000986 DNA binding site [nucleotide binding] 552526000987 AAA domain; Region: AAA_30; pfam13604 552526000988 Family description; Region: UvrD_C_2; pfam13538 552526000989 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 552526000990 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 552526000991 Catalytic site [active] 552526000992 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 552526000993 ribonuclease HIII; Provisional; Region: PRK00996 552526000994 Domain of unknown function (DUF3378); Region: DUF3378; pfam11858 552526000995 bacterial Ribonuclease HIII-like; Region: RNase_HII_bacteria_HIII_like; cd06590 552526000996 RNA/DNA hybrid binding site [nucleotide binding]; other site 552526000997 active site 552526000998 Uncharacterized membrane protein, required for colicin V production [General function prediction only]; Region: CvpA; COG1286 552526000999 Colicin V production protein; Region: Colicin_V; pfam02674 552526001000 Mismatch repair ATPase (MutS family) [DNA replication, recombination, and repair]; Region: COG1193 552526001001 MutS domain III; Region: MutS_III; pfam05192 552526001002 ATP-binding cassette domain of MutS2; Region: ABC_MutS2; cd03280 552526001003 Walker A/P-loop; other site 552526001004 ATP binding site [chemical binding]; other site 552526001005 Q-loop/lid; other site 552526001006 ABC transporter signature motif; other site 552526001007 Walker B; other site 552526001008 D-loop; other site 552526001009 H-loop/switch region; other site 552526001010 Smr domain; Region: Smr; pfam01713 552526001011 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 552526001012 pyridine nucleotide-disulfide oxidoreductase; Provisional; Region: PRK07251 552526001013 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 552526001014 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 552526001015 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 552526001016 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 552526001017 catalytic residues [active] 552526001018 A/G-specific DNA glycosylase [DNA replication, recombination, and repair]; Region: MutY; COG1194 552526001019 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 552526001020 minor groove reading motif; other site 552526001021 helix-hairpin-helix signature motif; other site 552526001022 substrate binding pocket [chemical binding]; other site 552526001023 active site 552526001024 DNA glycosylase (MutY in bacteria and hMYH in humans) is responsible for repairing misread A*oxoG residues to C*G by removing the inappropriately paired adenine base from the DNA backbone. It belongs to the Nudix hydrolase superfamily and is important...; Region: DNA_Glycosylase_C; cd03431 552526001025 DNA binding and oxoG recognition site [nucleotide binding] 552526001026 30S ribosomal protein S6; Reviewed; Region: rpsF; PRK00453 552526001027 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 552526001028 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 552526001029 dimer interface [polypeptide binding]; other site 552526001030 ssDNA binding site [nucleotide binding]; other site 552526001031 tetramer (dimer of dimers) interface [polypeptide binding]; other site 552526001032 30S ribosomal protein S18; Reviewed; Region: rpsR; PRK00391 552526001033 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 552526001034 Helix-turn-helix domain; Region: HTH_28; pfam13518 552526001035 putative transposase OrfB; Reviewed; Region: PHA02517 552526001036 HTH-like domain; Region: HTH_21; pfam13276 552526001037 Integrase core domain; Region: rve; pfam00665 552526001038 Integrase core domain; Region: rve_2; pfam13333 552526001039 Protein of unknown function (DUF1129); Region: DUF1129; cl11555 552526001040 Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598 552526001041 uncharacterized bacterial subfamily of the Escherichia coli CorA-Salmonella typhimurium ZntB family; Region: EcCorA_ZntB-like_u2; cd12827 552526001042 Cl binding site [ion binding]; other site 552526001043 oligomer interface [polypeptide binding]; other site 552526001044 excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349 552526001045 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 552526001046 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 552526001047 ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271 552526001048 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 552526001049 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 552526001050 Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092 552526001051 active site 552526001052 Deoxycytidylate deaminase domain. Deoxycytidylate deaminase catalyzes the deamination of dCMP to dUMP, providing the nucleotide substrate for thymidylate synthase. The enzyme binds Zn++, which is required for catalytic activity. The activity of the...; Region: deoxycytidylate_deaminase; cd01286 552526001053 catalytic motif [active] 552526001054 Zn binding site [ion binding]; other site 552526001055 elongation factor P; Validated; Region: PRK00529 552526001056 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 552526001057 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 552526001058 RNA binding site [nucleotide binding]; other site 552526001059 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 552526001060 RNA binding site [nucleotide binding]; other site 552526001061 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1302 552526001062 transcription antitermination protein NusB; Reviewed; Region: nusB; PRK00202 552526001063 putative RNA binding site [nucleotide binding]; other site 552526001064 Transcriptional regulators [Transcription]; Region: PurR; COG1609 552526001065 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 552526001066 DNA binding site [nucleotide binding] 552526001067 domain linker motif; other site 552526001068 Ligand binding domain of the lacI-like transcription regulator from a novel metal-reducing bacterium Alkaliphilus Metalliredigens (strain Qymf) and its close homologs; Region: PBP1_Qymf_like; cd06291 552526001069 dimerization interface [polypeptide binding]; other site 552526001070 ligand binding site [chemical binding]; other site 552526001071 sodium binding site [ion binding]; other site 552526001072 sucrose-6-phosphate hydrolase; Region: scrB_fam; TIGR01322 552526001073 Glycosyl hydrolase family 32, beta-fructosidases; Region: GH32_B_Fructosidase; cd08996 552526001074 substrate binding [chemical binding]; other site 552526001075 active site 552526001076 Glycosyl hydrolases family 32 C terminal; Region: Glyco_hydro_32C; pfam08244 552526001077 PTS system, sucrose-specific IIBC component; Region: PTS-II-BC-sucr; TIGR01996 552526001078 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 552526001079 active site turn [active] 552526001080 phosphorylation site [posttranslational modification] 552526001081 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 552526001082 Phosphotransferase system IIA components [Carbohydrate transport and metabolism]; Region: NagE; COG2190 552526001083 HPr interaction site; other site 552526001084 glycerol kinase (GK) interaction site [polypeptide binding]; other site 552526001085 active site 552526001086 phosphorylation site [posttranslational modification] 552526001087 Endo-beta-N-acetylglucosaminidases are bacterial chitinases that hydrolyze the chitin core of various asparagine (N)-linked glycans and glycoproteins. The endo-beta-N-acetylglucosaminidases have a glycosyl hydrolase family 18 (GH18) catalytic domain; Region: GH18_EndoS-like; cd06542 552526001088 active site 552526001089 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 552526001090 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 552526001091 nucleotide binding site [chemical binding]; other site 552526001092 Phosphomannose isomerase [Carbohydrate transport and metabolism]; Region: ManA; COG1482 552526001093 mannose-6-phosphate isomerase, class I; Region: manA; TIGR00218 552526001094 preprotein translocase subunit SecA; Reviewed; Region: PRK12904 552526001095 SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958 552526001096 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cl17351 552526001097 nucleotide binding region [chemical binding]; other site 552526001098 ATP-binding site [chemical binding]; other site 552526001099 SEC-C motif; Region: SEC-C; pfam02810 552526001100 4'-phosphopantetheinyl transferase; Provisional; Region: acpS; PRK00070 552526001101 alanine racemase; Reviewed; Region: alr; PRK00053 552526001102 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430 552526001103 active site 552526001104 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 552526001105 dimer interface [polypeptide binding]; other site 552526001106 substrate binding site [chemical binding]; other site 552526001107 catalytic residues [active] 552526001108 Surface antigen [General function prediction only]; Region: COG3942 552526001109 CHAP domain; Region: CHAP; pfam05257 552526001110 Protein of unknown function (DUF1533); Region: DUF1533; pfam07550 552526001111 NEAr Transport domain, a component of cell surface proteins; Region: NEAT; cd06920 552526001112 heme-binding site [chemical binding]; other site 552526001113 Leucine rich repeat; Region: LRR_8; pfam13855 552526001114 Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond...; Region: LRR_RI; cl15309 552526001115 Leucine rich repeat; Region: LRR_8; pfam13855 552526001116 Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond...; Region: LRR_RI; cl15309 552526001117 Leucine-rich repeats; other site 552526001118 Leucine rich repeat; Region: LRR_8; pfam13855 552526001119 Leucine rich repeat; Region: LRR_8; pfam13855 552526001120 NEAr Transport domain, a component of cell surface proteins; Region: NEAT; cd06920 552526001121 heme-binding site [chemical binding]; other site 552526001122 Cell surface heme-binding protein Shp; Region: HemeBinding_Shp; pfam11545 552526001123 heme ABC transporter, heme-binding protein isdE; Region: IsdE; TIGR03659 552526001124 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 552526001125 intersubunit interface [polypeptide binding]; other site 552526001126 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 552526001127 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 552526001128 ABC-ATPase subunit interface; other site 552526001129 dimer interface [polypeptide binding]; other site 552526001130 putative PBP binding regions; other site 552526001131 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 552526001132 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 552526001133 Walker A/P-loop; other site 552526001134 ATP binding site [chemical binding]; other site 552526001135 Q-loop/lid; other site 552526001136 ABC transporter signature motif; other site 552526001137 Walker B; other site 552526001138 D-loop; other site 552526001139 H-loop/switch region; other site 552526001140 ABC-type transport system involved in cytochrome bd biosynthesis, ATPase and permease components [Energy production and conversion / Posttranslational modification, protein turnover, chaperones]; Region: CydD; COG4988 552526001141 ATP-binding cassette domain of multidrug resistance protein-like transporters; Region: ABCC_MRP_Like; cd03228 552526001142 Walker A/P-loop; other site 552526001143 ATP binding site [chemical binding]; other site 552526001144 Q-loop/lid; other site 552526001145 ABC transporter signature motif; other site 552526001146 Walker B; other site 552526001147 D-loop; other site 552526001148 H-loop/switch region; other site 552526001149 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 552526001150 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 552526001151 ATP-binding cassette domain of multidrug resistance protein-like transporters; Region: ABCC_MRP_Like; cd03228 552526001152 Walker A/P-loop; other site 552526001153 ATP binding site [chemical binding]; other site 552526001154 Q-loop/lid; other site 552526001155 ABC transporter signature motif; other site 552526001156 Walker B; other site 552526001157 D-loop; other site 552526001158 H-loop/switch region; other site 552526001159 Hypothetical bacterial integral membrane protein (Trep_Strep); Region: Trep_Strep; pfam09605 552526001160 ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619 552526001161 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 552526001162 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 552526001163 Walker A/P-loop; other site 552526001164 ATP binding site [chemical binding]; other site 552526001165 Q-loop/lid; other site 552526001166 ABC transporter signature motif; other site 552526001167 Walker B; other site 552526001168 D-loop; other site 552526001169 H-loop/switch region; other site 552526001170 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 552526001171 Walker A/P-loop; other site 552526001172 ATP binding site [chemical binding]; other site 552526001173 ABC transporter; Region: ABC_tran; pfam00005 552526001174 Q-loop/lid; other site 552526001175 ABC transporter signature motif; other site 552526001176 Walker B; other site 552526001177 D-loop; other site 552526001178 H-loop/switch region; other site 552526001179 ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917 552526001180 RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488 552526001181 generic binding surface II; other site 552526001182 ssDNA binding site; other site 552526001183 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 552526001184 ATP binding site [chemical binding]; other site 552526001185 putative Mg++ binding site [ion binding]; other site 552526001186 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 552526001187 nucleotide binding region [chemical binding]; other site 552526001188 ATP-binding site [chemical binding]; other site 552526001189 Type II (periplasmic) bacterial L-asparaginase; Region: L-asparaginase_II; cd08964 552526001190 active site 552526001191 homodimer interface [polypeptide binding]; other site 552526001192 homotetramer interface [polypeptide binding]; other site 552526001193 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 552526001194 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 552526001195 active site 552526001196 motif I; other site 552526001197 motif II; other site 552526001198 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cl17915 552526001199 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4696 552526001200 metal binding site [ion binding]; metal-binding site 552526001201 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 552526001202 Ligand Binding Site [chemical binding]; other site 552526001203 Pleiotropic transcriptional repressor [Transcription]; Region: CodY; COG4465 552526001204 CodY GAF-like domain; Region: CodY; pfam06018 552526001205 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 552526001206 dimerization interface [polypeptide binding]; other site 552526001207 putative Zn2+ binding site [ion binding]; other site 552526001208 putative DNA binding site [nucleotide binding]; other site 552526001209 Isochorismatase family; Region: Isochorismatase; pfam00857 552526001210 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 552526001211 catalytic triad [active] 552526001212 conserved cis-peptide bond; other site 552526001213 aspartyl/glutamyl-tRNA amidotransferase subunit C; Reviewed; Region: gatC; PRK00034 552526001214 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 552526001215 aspartyl/glutamyl-tRNA amidotransferase subunit A; Reviewed; Region: gatA; PRK00012 552526001216 aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477 552526001217 GatB/GatE catalytic domain; Region: GatB_N; pfam02934 552526001218 GatB domain; Region: GatB_Yqey; pfam02637 552526001219 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 552526001220 EamA-like transporter family; Region: EamA; pfam00892 552526001221 Predicted membrane protein [Function unknown]; Region: COG2261 552526001222 KxYKxGKxW signal peptide; Region: KxYKxGKxW; TIGR03715 552526001223 ACT domain proteins similar to the yet uncharacterized Streptococcus pneumoniae ACT domain protein; Region: ACT_1ZPV; cd04872 552526001224 Uncharacterized proteins with similarity to Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL_like_DUF711; cd08025 552526001225 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 552526001226 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 552526001227 D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: VanY; COG1876 552526001228 D-alanyl-D-alanine carboxypeptidase; Region: VanY; pfam02557 552526001229 Mannosyl-glycoprotein endo-beta-N-acetylglucosaminidase; Region: Glucosaminidase; cl17361 552526001230 heat-inducible transcription repressor; Provisional; Region: hrcA; PRK00082 552526001231 GrpE; Region: GrpE; pfam01025 552526001232 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446 552526001233 dimer interface [polypeptide binding]; other site 552526001234 hsp70 (ATPase domain) interactions [polypeptide binding]; other site 552526001235 molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290 552526001236 Nucleotide-binding domain of human HSPA9 and similar proteins; Region: HSPA9-Ssq1-like_NBD; cd10234 552526001237 nucleotide binding site [chemical binding]; other site 552526001238 NEF interaction site [polypeptide binding]; other site 552526001239 SBD interface [polypeptide binding]; other site 552526001240 chaperone protein DnaJ; Provisional; Region: PRK14276 552526001241 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 552526001242 HSP70 interaction site [polypeptide binding]; other site 552526001243 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cl03262 552526001244 substrate binding site [polypeptide binding]; other site 552526001245 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 552526001246 Zn binding sites [ion binding]; other site 552526001247 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 552526001248 dimer interface [polypeptide binding]; other site 552526001249 enoyl-CoA hydratase; Provisional; Region: PRK07260 552526001250 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 552526001251 substrate binding site [chemical binding]; other site 552526001252 oxyanion hole (OAH) forming residues; other site 552526001253 trimer interface [polypeptide binding]; other site 552526001254 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 552526001255 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 552526001256 putative Zn2+ binding site [ion binding]; other site 552526001257 putative DNA binding site [nucleotide binding]; other site 552526001258 dimerization interface [polypeptide binding]; other site 552526001259 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352 552526001260 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 552526001261 dimer interface [polypeptide binding]; other site 552526001262 active site 552526001263 CoA binding pocket [chemical binding]; other site 552526001264 acyl carrier protein; Provisional; Region: acpP; PRK00982 552526001265 putative enoyl-[acyl-carrier-protein] reductase II; Region: enACPred_II; TIGR03151 552526001266 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 552526001267 FMN binding site [chemical binding]; other site 552526001268 substrate binding site [chemical binding]; other site 552526001269 putative catalytic residue [active] 552526001270 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 552526001271 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 552526001272 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 552526001273 beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333 552526001274 NAD(P) binding site [chemical binding]; other site 552526001275 homotetramer interface [polypeptide binding]; other site 552526001276 homodimer interface [polypeptide binding]; other site 552526001277 active site 552526001278 3-oxoacyl-(acyl carrier protein) synthase II; Reviewed; Region: PRK07314 552526001279 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 552526001280 dimer interface [polypeptide binding]; other site 552526001281 active site 552526001282 acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated; Region: PRK06302 552526001283 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 552526001284 carboxyltransferase (CT) interaction site; other site 552526001285 biotinylation site [posttranslational modification]; other site 552526001286 FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288 552526001287 acetyl-CoA carboxylase subunit beta; Validated; Region: PRK05654 552526001288 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 552526001289 acetyl-CoA carboxylase subunit alpha; Provisional; Region: PRK12319 552526001290 seryl-tRNA synthetase; Provisional; Region: PRK05431 552526001291 Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403 552526001292 Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770 552526001293 dimer interface [polypeptide binding]; other site 552526001294 active site 552526001295 motif 1; other site 552526001296 motif 2; other site 552526001297 motif 3; other site 552526001298 Predicted O-acyltransferase [General function prediction only]; Region: COG3274 552526001299 Acyltransferase family; Region: Acyl_transf_3; pfam01757 552526001300 Domain of unknown function (DUF956); Region: DUF956; cl01917 552526001301 Phosphotransferase system, mannose/fructose/N-acetylgalactosamine-specific component IID [Carbohydrate transport and metabolism]; Region: ManZ; COG3716 552526001302 PTS system mannose-specific transporter subunit IIC; Provisional; Region: PRK15065 552526001303 PTS system mannose-specific transporter subunits IIAB; Provisional; Region: PRK15088 552526001304 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006 552526001305 active pocket/dimerization site; other site 552526001306 active site 552526001307 phosphorylation site [posttranslational modification] 552526001308 PTS_IIB, PTS system, Mannose/sorbose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_man; cd00001 552526001309 active site 552526001310 phosphorylation site [posttranslational modification] 552526001311 Predicted hydrolases of the HAD superfamily [General function prediction only]; Region: Cof; COG0561 552526001312 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 552526001313 active site 552526001314 motif I; other site 552526001315 motif II; other site 552526001316 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 552526001317 Predicted transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: COG1548; cl00668 552526001318 Predicted ATPase or kinase [General function prediction only]; Region: COG0802 552526001319 putative acetyltransferase YhhY; Provisional; Region: PRK10140 552526001320 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 552526001321 Coenzyme A binding pocket [chemical binding]; other site 552526001322 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 552526001323 Transcriptional regulator [Transcription]; Region: LytR; COG1316 552526001324 HINT (histidine triad nucleotide-binding protein) subgroup: Members of this CD belong to the superfamily of histidine triad hydrolases that act on alpha-phosphate of ribonucleotides. This subgroup includes members from all three forms of cellular life; Region: HINT_subgroup; cd01277 552526001325 HIT family signature motif; other site 552526001326 catalytic residue [active] 552526001327 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 552526001328 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 552526001329 Walker A/P-loop; other site 552526001330 ATP binding site [chemical binding]; other site 552526001331 Q-loop/lid; other site 552526001332 ABC transporter signature motif; other site 552526001333 Walker B; other site 552526001334 D-loop; other site 552526001335 H-loop/switch region; other site 552526001336 Bacterial ABC transporter protein EcsB; Region: EcsB; cl11542 552526001337 Bacterial ABC transporter protein EcsB; Region: EcsB; cl11542 552526001338 Thiamine kinase and related kinases [Coenzyme transport and metabolism]; Region: ycfN; COG0510 552526001339 Phosphotransferase enzyme family; Region: APH; pfam01636 552526001340 substrate binding site [chemical binding]; other site 552526001341 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 552526001342 S-adenosylmethionine binding site [chemical binding]; other site 552526001343 ribosome maturation protein RimP; Reviewed; Region: PRK00092 552526001344 Bacillus subtilis YxlS-like, C-terminal domain; Region: YlxS_C; cd01734 552526001345 putative oligomer interface [polypeptide binding]; other site 552526001346 putative RNA binding site [nucleotide binding]; other site 552526001347 transcription elongation factor NusA; Provisional; Region: nusA; PRK12327 552526001348 NusA N-terminal domain; Region: NusA_N; pfam08529 552526001349 S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455 552526001350 RNA binding site [nucleotide binding]; other site 552526001351 homodimer interface [polypeptide binding]; other site 552526001352 NusA-like KH domain; Region: KH_5; pfam13184 552526001353 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 552526001354 G-X-X-G motif; other site 552526001355 Ylxr homologs; group of conserved hypothetical bacterial proteins of unknown function; structure revealed putative RNA binding cleft; proteins are encoded by an operon that includes other proteins involved in transcription and/or translation; Region: YlxR; cd00279 552526001356 putative RNA binding cleft [nucleotide binding]; other site 552526001357 hypothetical protein; Provisional; Region: PRK07283 552526001358 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 552526001359 translation initiation factor IF-2; Region: IF-2; TIGR00487 552526001360 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 552526001361 Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887 552526001362 G1 box; other site 552526001363 putative GEF interaction site [polypeptide binding]; other site 552526001364 GTP/Mg2+ binding site [chemical binding]; other site 552526001365 Switch I region; other site 552526001366 G2 box; other site 552526001367 G3 box; other site 552526001368 Switch II region; other site 552526001369 G4 box; other site 552526001370 G5 box; other site 552526001371 This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702 552526001372 Translation-initiation factor 2; Region: IF-2; pfam11987 552526001373 mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692 552526001374 ribosome-binding factor A; Validated; Region: rbfA; PRK00521 552526001375 Protein of unknown function (DUF2424); Region: DUF2424; pfam10340 552526001376 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 552526001377 copper transport repressor, CopY/TcrY family; Region: CopY_TcrY; TIGR02698 552526001378 Penicillinase repressor; Region: Pencillinase_R; pfam03965 552526001379 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 552526001380 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 552526001381 metal-binding site [ion binding] 552526001382 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 552526001383 Soluble P-type ATPase [General function prediction only]; Region: COG4087 552526001384 Protein of unknown function (DUF3137); Region: DUF3137; pfam11335 552526001385 LemA family; Region: LemA; cl00742 552526001386 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 552526001387 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 552526001388 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 552526001389 galactose-6-phosphate isomerase subunit LacA; Provisional; Region: PRK12613 552526001390 galactose-6-phosphate isomerase subunit LacB; Reviewed; Region: PRK12615 552526001391 1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164 552526001392 tagatose-6-phosphate kinase; Region: lacC; TIGR01231 552526001393 putative substrate binding site [chemical binding]; other site 552526001394 putative ATP binding site [chemical binding]; other site 552526001395 tagatose 1,6-diphosphate aldolase; Reviewed; Region: PRK12399 552526001396 CAT RNA binding domain; Region: CAT_RBD; smart01061 552526001397 transcriptional antiterminator BglG; Provisional; Region: PRK09772 552526001398 PRD domain; Region: PRD; pfam00874 552526001399 PRD domain; Region: PRD; pfam00874 552526001400 PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_lac; cd00215 552526001401 methionine cluster; other site 552526001402 active site 552526001403 phosphorylation site [posttranslational modification] 552526001404 metal binding site [ion binding]; metal-binding site 552526001405 phosphotransferase system, lactose specific, IIC component; Region: lac_pts_IIC; TIGR00394 552526001406 Phosphotransferase system, EIIC; Region: PTS_EIIC; pfam02378 552526001407 PTS_IIB_lactose: subunit IIB of enzyme II (EII) of the lactose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS) found in Firmicutes as well as Actinobacteria. In this system, EII is a lactose-specific permease with two...; Region: PTS_IIB_lactose; cd05565 552526001408 active site 552526001409 P-loop; other site 552526001410 phosphorylation site [posttranslational modification] 552526001411 6-phospho-beta-galactosidase; Provisional; Region: PRK13511 552526001412 beta-galactosidase; Region: BGL; TIGR03356 552526001413 Domain of unknown function (DUF4300); Region: DUF4300; pfam14133 552526001414 Predicted membrane protein [Function unknown]; Region: COG2860 552526001415 UPF0126 domain; Region: UPF0126; pfam03458 552526001416 UPF0126 domain; Region: UPF0126; pfam03458 552526001417 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 552526001418 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 552526001419 active site 552526001420 motif I; other site 552526001421 motif II; other site 552526001422 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 552526001423 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 552526001424 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 552526001425 Uncharacterized protein conserved in bacteria [Function unknown]; Region: DegV; COG1307 552526001426 Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645 552526001427 Transcriptional regulators [Transcription]; Region: PurR; COG1609 552526001428 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 552526001429 DNA binding site [nucleotide binding] 552526001430 domain linker motif; other site 552526001431 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 552526001432 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 552526001433 Ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This reaction is the first step in the ribose metabolism. It traps ribose within the cell after uptake and also prepares the sugar for use in the synthesis of nucleotides...; Region: ribokinase; cd01174 552526001434 substrate binding site [chemical binding]; other site 552526001435 dimer interface [polypeptide binding]; other site 552526001436 ATP binding site [chemical binding]; other site 552526001437 D-ribose pyranase; Provisional; Region: PRK11797 552526001438 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 552526001439 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 552526001440 Walker A/P-loop; other site 552526001441 ATP binding site [chemical binding]; other site 552526001442 Q-loop/lid; other site 552526001443 ABC transporter signature motif; other site 552526001444 Walker B; other site 552526001445 D-loop; other site 552526001446 H-loop/switch region; other site 552526001447 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 552526001448 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 552526001449 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 552526001450 TM-ABC transporter signature motif; other site 552526001451 D-ribose transporter subunit RbsB; Provisional; Region: PRK10653 552526001452 Periplasmic sugar-binding domain of the thermophilic Thermoanaerobacter tengcongensis ribose binding protein (ttRBP) and its mesophilic homologs; Region: PBP1_ribose_binding; cd06323 552526001453 ligand binding site [chemical binding]; other site 552526001454 dimerization interface [polypeptide binding]; other site 552526001455 Na+/phosphate symporter [Inorganic ion transport and metabolism]; Region: NptA; COG1283 552526001456 Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690 552526001457 Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690 552526001458 PhoU domain; Region: PhoU; pfam01895 552526001459 PhoU domain; Region: PhoU; pfam01895 552526001460 N-acetylglucosamine-6-phosphate deacetylase [Carbohydrate transport and metabolism]; Region: NagA; COG1820 552526001461 N-acetylglucosamine-6-phosphate deacetylase, NagA, catalyzes the hydrolysis of the N-acetyl group of N-acetyl-glucosamine-6-phosphate (GlcNAc-6-P) to glucosamine 6-phosphate and acetate. This is the first committed step in the biosynthetic pathway to...; Region: NagA; cd00854 552526001462 active site 552526001463 dimer interface [polypeptide binding]; other site 552526001464 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 552526001465 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 552526001466 active site 552526001467 catalytic tetrad [active] 552526001468 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 552526001469 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 552526001470 Walker A/P-loop; other site 552526001471 ATP binding site [chemical binding]; other site 552526001472 Q-loop/lid; other site 552526001473 ABC transporter signature motif; other site 552526001474 Walker B; other site 552526001475 D-loop; other site 552526001476 H-loop/switch region; other site 552526001477 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1755 552526001478 Class II Glycyl-tRNA synthetase (GlyRS) alpha subunit core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes and in arabidopsis. It is responsible for the...; Region: GlyRS_alpha_core; cd00733 552526001479 dimer interface [polypeptide binding]; other site 552526001480 motif 1; other site 552526001481 active site 552526001482 motif 2; other site 552526001483 motif 3; other site 552526001484 glycyl-tRNA synthetase subunit beta; Validated; Region: glyS; PRK01233 552526001485 DALR anticodon binding domain; Region: DALR_1; pfam05746 552526001486 hypothetical protein; Provisional; Region: PRK02539 552526001487 bacteriocin protoxin, streptolysin S family; Region: streptolysinS; TIGR03602 552526001488 This family is the oxydase domain of NRPS (non-ribosomal peptide synthetase) and other proteins that modify polypeptides by cyclizing a thioester to form a ring. These include epoB, part of the epothilone biosynthesis pathway; tubD, part of the tubulysin...; Region: mcbC-like_oxidoreductase; cd02142 552526001489 putative FMN binding site [chemical binding]; other site 552526001490 NADPH bind site [chemical binding]; other site 552526001491 thiazole/oxazole-forming peptide maturase, SagC family component; Region: cyclo_dehy_ocin; TIGR03603 552526001492 thiazole/oxazole-forming peptide maturase, SagD family component; Region: TOMM_cyclo_SagD; TIGR03604 552526001493 YcaO-like family; Region: YcaO; pfam02624 552526001494 CAAX protease self-immunity; Region: Abi; pfam02517 552526001495 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 552526001496 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 552526001497 Walker A/P-loop; other site 552526001498 ATP binding site [chemical binding]; other site 552526001499 Q-loop/lid; other site 552526001500 ABC transporter signature motif; other site 552526001501 Walker B; other site 552526001502 D-loop; other site 552526001503 H-loop/switch region; other site 552526001504 ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698 552526001505 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 552526001506 ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698 552526001507 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 552526001508 Fibronectin-binding protein signal sequence; Region: Fb_signal; pfam08341 552526001509 TQXA domain; Region: TQXA_dom; TIGR03934 552526001510 Fibronectin-binding protein signal sequence; Region: Fb_signal; pfam08341 552526001511 TQXA domain; Region: TQXA_dom; TIGR03934 552526001512 CutC family; Region: CutC; pfam03932 552526001513 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 552526001514 Coenzyme A binding pocket [chemical binding]; other site 552526001515 DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; pfam13808 552526001516 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 552526001517 DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; cl17880 552526001518 Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350 552526001519 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 552526001520 DNA binding site [nucleotide binding] 552526001521 active site 552526001522 Arsenate Reductase (ArsC) family, unknown subfamily; uncharacterized proteins containing a CXXC motif with similarity to thioredoxin (TRX)-fold arsenic reductases, ArsC. Proteins containing a redox active CXXC motif like TRX and glutaredoxin (GRX)...; Region: ArsC_like; cd03036 552526001523 ArsC family; Region: ArsC; pfam03960 552526001524 putative ArsC-like catalytic residues; other site 552526001525 putative TRX-like catalytic residues [active] 552526001526 Human Ape1-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: Ape1-like_AP-endo; cd09087 552526001527 active site 552526001528 putative catalytic site [active] 552526001529 DNA binding site [nucleotide binding] 552526001530 putative phosphate binding site [ion binding]; other site 552526001531 metal binding site A [ion binding]; metal-binding site 552526001532 AP binding site [nucleotide binding]; other site 552526001533 metal binding site B [ion binding]; metal-binding site 552526001534 Gram-positive signal peptide, YSIRK family; Region: YSIRK_signal; TIGR01168 552526001535 Peptidase S8 family domain in Streptococcal C5a peptidases; Region: Peptidases_S8_C5a_Peptidase; cd07475 552526001536 putative active site [active] 552526001537 catalytic triad [active] 552526001538 PA_C5a_like: Protease-associated domain containing proteins like Streptococcus pyogenes C5a peptidase. This group contains various PA domain-containing proteins similar to S. pyogenes C5a, including, i) Vpr, a minor extracellular serine protease from...; Region: PA_C5a_like; cd02133 552526001539 putative integrin binding motif; other site 552526001540 PA/protease domain interface [polypeptide binding]; other site 552526001541 Peptidase S8 family domain in Streptococcal C5a peptidases; Region: Peptidases_S8_C5a_Peptidase; cd07475 552526001542 Fn3-like domain (DUF1034); Region: DUF1034; pfam06280 552526001543 YSIRK type signal peptide; Region: YSIRK_signal; cl04650 552526001544 Predicted membrane protein [Function unknown]; Region: COG3619 552526001545 methionyl-tRNA synthetase; Reviewed; Region: PRK12267 552526001546 catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814 552526001547 active site 552526001548 HIGH motif; other site 552526001549 KMSKS motif; other site 552526001550 Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957 552526001551 tRNA binding surface [nucleotide binding]; other site 552526001552 anticodon binding site; other site 552526001553 tRNA-binding-domain-containing Escherichia coli methionyl-tRNA synthetase (EcMetRS)-like proteins. This family includes EcMetRS and Aquifex aeolicus Trbp111 (AaTrbp111). This domain has general tRNA binding properties. MetRS aminoacylates methionine...; Region: tRNA_bind_EcMetRS_like; cd02800 552526001554 dimer interface [polypeptide binding]; other site 552526001555 putative tRNA-binding site [nucleotide binding]; other site 552526001556 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 552526001557 non-specific DNA binding site [nucleotide binding]; other site 552526001558 salt bridge; other site 552526001559 sequence-specific DNA binding site [nucleotide binding]; other site 552526001560 A sub-family of peptidase family C39. Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various...; Region: Peptidase_C39B; cd02418 552526001561 ABC-type bacteriocin transporter; Region: bacteriocin_ABC; TIGR01193 552526001562 putative active site [active] 552526001563 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 552526001564 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 552526001565 Walker A/P-loop; other site 552526001566 ATP binding site [chemical binding]; other site 552526001567 Q-loop/lid; other site 552526001568 ABC transporter signature motif; other site 552526001569 Walker B; other site 552526001570 D-loop; other site 552526001571 H-loop/switch region; other site 552526001572 bacteriocin secretion accessory protein; Region: bacteriocin_acc; TIGR01000 552526001573 HlyD family secretion protein; Region: HlyD_3; pfam13437 552526001574 ribonucleotide-diphosphate reductase subunit beta; Provisional; Region: nrdF2; PRK13966 552526001575 Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049 552526001576 dimer interface [polypeptide binding]; other site 552526001577 putative radical transfer pathway; other site 552526001578 diiron center [ion binding]; other site 552526001579 tyrosyl radical; other site 552526001580 ribonucleotide reductase stimulatory protein; Reviewed; Region: nrdI; PRK03600 552526001581 ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK07187 552526001582 Ribonucleotide reductase N-terminal; Region: RNR_N; pfam08343 552526001583 Class I ribonucleotide reductase; Region: RNR_I; cd01679 552526001584 active site 552526001585 dimer interface [polypeptide binding]; other site 552526001586 catalytic residues [active] 552526001587 effector binding site; other site 552526001588 Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939 552526001589 Branched-chain amino acid transport protein; Region: Branch_AA_trans; cl00547 552526001590 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 552526001591 Transposase; Region: DDE_Tnp_ISL3; pfam01610 552526001592 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4842 552526001593 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061 552526001594 WXG100 protein secretion system (Wss), protein YukD; Region: YukD; cl17489 552526001595 WXG100 protein secretion system (Wss), protein YukC; Region: YukC; cl01868 552526001596 type VII secretion protein EssB; Region: T7_EssB; TIGR03926 552526001597 type VII secretion protein EssC, C-terminal domain; Region: T7_EssCb_Firm; TIGR03928 552526001598 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 552526001599 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 552526001600 Domain of unknown function (DUF4176); Region: DUF4176; pfam13780 552526001601 Protein of unknown function (DUF3130; Region: DUF3130; cl12867 552526001602 LXG domain of WXG superfamily; Region: LXG; pfam04740 552526001603 Protein of unknown function (DUF4225); Region: DUF4225; pfam13988 552526001604 Protein of unknown function (DUF4237); Region: DUF4237; pfam14021 552526001605 CRISPR/Cas system-associated protein Cas3'' Region: Cas3''_I; cd09641 552526001606 CRISPR-associated helicase Cas3 [Defense mechanisms]; Region: COG1203 552526001607 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 552526001608 CRISPR/Cas system-associated RAMP superfamily protein Cas5; Region: Cas5_I; cl12040 552526001609 CRISPR-associated protein (Cas_Cas5); Region: Cas_Cas5d; pfam09704 552526001610 CRISPR/Cas system-associated protein Cas8c; Region: Cas8c_I-C; cl12004 552526001611 CRISPR/Cas system-associated RAMP superfamily protein Cas7; Region: Cas7_I-C; cl01465 552526001612 CRISPR-associated protein Cas4 (RecB family exonuclease) [Defense mechanisms]; Region: COG1468 552526001613 CRISPR/Cas system-associated protein Cas1; Region: Cas1_I-C; cd09721 552526001614 CRISPR/Cas system-associated protein Cas2; Region: Cas2_I_II_III; cd09725 552526001615 Cytochrome c biogenesis protein [Posttranslational modification, protein turnover, chaperones]; Region: CcdA; COG0785 552526001616 Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788 552526001617 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 552526001618 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 552526001619 catalytic residues [active] 552526001620 Peptide methionine sulfoxide reductase [Posttranslational modification, protein turnover, chaperones]; Region: MsrA; COG0225 552526001621 Conserved domain frequently associated with peptide methionine sulfoxide reductase [Posttranslational modification, protein turnover, chaperones]; Region: COG0229 552526001622 SelR domain; Region: SelR; pfam01641 552526001623 Response regulator receiver domain; Region: Response_reg; pfam00072 552526001624 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 552526001625 active site 552526001626 phosphorylation site [posttranslational modification] 552526001627 intermolecular recognition site; other site 552526001628 dimerization interface [polypeptide binding]; other site 552526001629 Helix-turn-helix domain; Region: HTH_18; pfam12833 552526001630 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 552526001631 Cache domain; Region: Cache_1; pfam02743 552526001632 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 552526001633 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 552526001634 dimerization interface [polypeptide binding]; other site 552526001635 Histidine kinase; Region: His_kinase; pfam06580 552526001636 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 552526001637 ATP binding site [chemical binding]; other site 552526001638 Mg2+ binding site [ion binding]; other site 552526001639 G-X-G motif; other site 552526001640 Uncharacterized protein conserved in bacteria [Function unknown]; Region: MmcQ; COG2315 552526001641 Solo B3/4 domain (OB-fold DNA/RNA-binding) of Phe-aaRS-beta [General function prediction only]; Region: COG3382 552526001642 B3/4 domain; Region: B3_4; pfam03483 552526001643 This CD includes bacterial (Agrobacterium tumefaciens and Caulobacter crescentus ProX, and Clostridium sticklandii PrdX) and eukaryotic (Plasmodium falciparum N-terminal ProRS editing domain) sequences. The C. sticklandii PrdX protein, a homolog of the...; Region: PrdX_deacylase; cd04335 552526001644 putative deacylase active site [active] 552526001645 Arginine repressor [Transcription]; Region: ArgR; COG1438 552526001646 Arginine repressor, DNA binding domain; Region: Arg_repressor; pfam01316 552526001647 Arginine repressor, C-terminal domain; Region: Arg_repressor_C; pfam02863 552526001648 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 552526001649 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 552526001650 ligand binding site [chemical binding]; other site 552526001651 flexible hinge region; other site 552526001652 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 552526001653 putative switch regulator; other site 552526001654 non-specific DNA interactions [nucleotide binding]; other site 552526001655 DNA binding site [nucleotide binding] 552526001656 sequence specific DNA binding site [nucleotide binding]; other site 552526001657 putative cAMP binding site [chemical binding]; other site 552526001658 arginine deiminase; Provisional; Region: PRK01388 552526001659 Autoinducer synthetase; Region: Autoind_synth; cl17404 552526001660 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 552526001661 Coenzyme A binding pocket [chemical binding]; other site 552526001662 ornithine carbamoyltransferase; Validated; Region: PRK02102 552526001663 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 552526001664 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 552526001665 Predicted membrane protein [Function unknown]; Region: COG1288 552526001666 C4-dicarboxylate anaerobic carrier; Region: DcuC; pfam03606 552526001667 hypothetical protein; Provisional; Region: PRK07205 552526001668 M20 Peptidase Xaa-His dipeptidase (PepV) degrades hydrophobic dipeptides; Region: M20_PepV; cd03888 552526001669 active site 552526001670 metal binding site [ion binding]; metal-binding site 552526001671 carbamate kinase; Reviewed; Region: PRK12686 552526001672 AAK_CK: Carbamate kinase (CK) catalyzes both the ATP-phosphorylation of carbamate and carbamoyl phosphate (CP) utilization with the production of ATP from ADP and CP. Both CK (this CD) and nonhomologous CP synthetase synthesize carbamoyl phosphate, an...; Region: AAK_CK; cd04235 552526001673 putative substrate binding site [chemical binding]; other site 552526001674 nucleotide binding site [chemical binding]; other site 552526001675 nucleotide binding site [chemical binding]; other site 552526001676 homodimer interface [polypeptide binding]; other site 552526001677 Asparagine synthetase (aspartate-ammonia ligase) (AsnA) catalyses the conversion of L-aspartate to L-asparagine in the presence of ATP and ammonia. AsnA is a homodimeric enzyme which is structurally similiar to the catalytic core domain of class II...; Region: AsnA; cd00645 552526001678 dimer interface [polypeptide binding]; other site 552526001679 active site 552526001680 Conserved hypothetical protein 95; Region: Cons_hypoth95; pfam03602 552526001681 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 552526001682 S-adenosylmethionine binding site [chemical binding]; other site 552526001683 phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168 552526001684 Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163 552526001685 active site 552526001686 (T/H)XGH motif; other site 552526001687 Predicted secreted protein containing a PDZ domain [Signal transduction mechanisms]; Region: SdrC; COG3480 552526001688 PDZ domain, also called DHR (Dlg homologous region) or GLGF (after a conserved sequence motif). Many PDZ domains bind C-terminal polypeptides, though binding to internal (non-C-terminal) polypeptides and even to lipids has been demonstrated; Region: PDZ; cl00117 552526001689 protein binding site [polypeptide binding]; other site 552526001690 Protein of unknown function (DUF1027); Region: DUF1027; cl09961 552526001691 ribosomal RNA large subunit methyltransferase N; Provisional; Region: PRK14455 552526001692 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 552526001693 FeS/SAM binding site; other site 552526001694 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 552526001695 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 552526001696 Walker A/P-loop; other site 552526001697 ATP binding site [chemical binding]; other site 552526001698 Q-loop/lid; other site 552526001699 ABC transporter signature motif; other site 552526001700 Walker B; other site 552526001701 D-loop; other site 552526001702 H-loop/switch region; other site 552526001703 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 552526001704 Histidine kinase; Region: HisKA_3; pfam07730 552526001705 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 552526001706 ATP binding site [chemical binding]; other site 552526001707 Mg2+ binding site [ion binding]; other site 552526001708 G-X-G motif; other site 552526001709 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 552526001710 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 552526001711 active site 552526001712 phosphorylation site [posttranslational modification] 552526001713 intermolecular recognition site; other site 552526001714 dimerization interface [polypeptide binding]; other site 552526001715 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 552526001716 DNA binding residues [nucleotide binding] 552526001717 dimerization interface [polypeptide binding]; other site 552526001718 DNA-binding ferritin-like protein (oxidative damage protectant) [Inorganic ion transport and metabolism]; Region: Dps; COG0783 552526001719 DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043 552526001720 dimerization interface [polypeptide binding]; other site 552526001721 DPS ferroxidase diiron center [ion binding]; other site 552526001722 ion pore; other site 552526001723 Bacterial protein of unknown function (DUF910); Region: DUF910; pfam06014 552526001724 ROK family protein (putative glucokinase); Region: ROK_glcA_fam; TIGR00744 552526001725 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 552526001726 nucleotide binding site [chemical binding]; other site 552526001727 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 552526001728 active site residue [active] 552526001729 Predicted membrane GTPase involved in stress response [Signal transduction mechanisms]; Region: TypA; COG1217 552526001730 Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891 552526001731 G1 box; other site 552526001732 putative GEF interaction site [polypeptide binding]; other site 552526001733 GTP/Mg2+ binding site [chemical binding]; other site 552526001734 Switch I region; other site 552526001735 G2 box; other site 552526001736 G3 box; other site 552526001737 Switch II region; other site 552526001738 G4 box; other site 552526001739 G5 box; other site 552526001740 BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu. BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691 552526001741 BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants. BipA is a highly...; Region: BipA_TypA_C; cd03710 552526001742 Protein of unknown function (DUF3165); Region: DUF3165; pfam11364 552526001743 UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK02472 552526001744 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 552526001745 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 552526001746 undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726 552526001747 MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785 552526001748 active site 552526001749 homodimer interface [polypeptide binding]; other site 552526001750 Cell division septal protein [Cell envelope biogenesis, outer membrane]; Region: FtsQ; COG1589 552526001751 POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478 552526001752 Cell division protein FtsQ; Region: FtsQ; pfam03799 552526001753 Cell division ATPase FtsA [Cell division and chromosome partitioning]; Region: ftsA; COG0849 552526001754 Cell division protein FtsA; Region: FtsA; smart00842 552526001755 Cell division protein FtsA; Region: FtsA; pfam14450 552526001756 Domain of unknown function (DUF3484); Region: DUF3484; pfam11983 552526001757 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, YBL036c-like proteins; Region: PLPDE_III_YBL036c_like; cd00635 552526001758 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 552526001759 catalytic residue [active] 552526001760 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1799 552526001761 YGGT family; Region: YGGT; pfam02325 552526001762 Uncharacterized conserved protein, contains S4-like domain [Function unknown]; Region: COG2302 552526001763 DivIVA protein; Region: DivIVA; pfam05103 552526001764 DivIVA domain; Region: DivI1A_domain; TIGR03544 552526001765 isoleucyl-tRNA synthetase; Provisional; Region: ileS; PRK13804 552526001766 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 552526001767 active site 552526001768 HIGH motif; other site 552526001769 nucleotide binding site [chemical binding]; other site 552526001770 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 552526001771 active site 552526001772 KMSKS motif; other site 552526001773 Anticodon-binding domain of bacterial and eukaryotic mitochondrial isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_BEm; cd07960 552526001774 tRNA binding surface [nucleotide binding]; other site 552526001775 anticodon binding site; other site 552526001776 Domain of unknown function (DUF1827); Region: DUF1827; pfam08860 552526001777 Contains a crystal structure of the Nudix hydrolase from Enterococcus faecalis, which has an unknown function. In general, members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes...; Region: Nudix_Hydrolase_25; cd04684 552526001778 nudix motif; other site 552526001779 ATP-binding subunits of Clp protease and DnaK/DnaJ chaperones [Posttranslational modification, protein turnover, chaperones]; Region: clpA; COG0542 552526001780 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 552526001781 Walker A motif; other site 552526001782 ATP binding site [chemical binding]; other site 552526001783 Walker B motif; other site 552526001784 arginine finger; other site 552526001785 UvrB/uvrC motif; Region: UVR; pfam02151 552526001786 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 552526001787 Walker A motif; other site 552526001788 ATP binding site [chemical binding]; other site 552526001789 Walker B motif; other site 552526001790 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 552526001791 Protein of unknown function (DUF1797); Region: DUF1797; cl11550 552526001792 Collagen triple helix repeat (20 copies); Region: Collagen; pfam01391 552526001793 Gram positive anchor; Region: Gram_pos_anchor; pfam00746 552526001794 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 552526001795 dimer interface [polypeptide binding]; other site 552526001796 conserved gate region; other site 552526001797 ABC-ATPase subunit interface; other site 552526001798 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 552526001799 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 552526001800 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 552526001801 Walker A/P-loop; other site 552526001802 ATP binding site [chemical binding]; other site 552526001803 Q-loop/lid; other site 552526001804 ABC transporter signature motif; other site 552526001805 Walker B; other site 552526001806 D-loop; other site 552526001807 H-loop/switch region; other site 552526001808 phosphoglucomutase-2-like protein; Provisional; Region: PTZ00150 552526001809 This CD includes PGM2 (phosphoglucomutase 2) and PGM2L1 (phosphoglucomutase 2-like 1). The mammalian PGM2 is thought to be a phosphopentomutase that catalyzes the conversion of the nucleoside breakdown products, ribose-1-phosphate and...; Region: PGM2; cd05799 552526001810 active site 552526001811 substrate binding site [chemical binding]; other site 552526001812 metal binding site [ion binding]; metal-binding site 552526001813 bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK14179 552526001814 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763 552526001815 NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080 552526001816 homodimer interface [polypeptide binding]; other site 552526001817 NADP binding site [chemical binding]; other site 552526001818 substrate binding site [chemical binding]; other site 552526001819 B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171 552526001820 putative substrate binding site [chemical binding]; other site 552526001821 putative ATP binding site [chemical binding]; other site 552526001822 exodeoxyribonuclease VII large subunit; Reviewed; Region: xseA; PRK00286 552526001823 ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489 552526001824 generic binding surface II; other site 552526001825 generic binding surface I; other site 552526001826 exodeoxyribonuclease VII small subunit; Provisional; Region: PRK00977 552526001827 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 552526001828 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 552526001829 substrate binding pocket [chemical binding]; other site 552526001830 chain length determination region; other site 552526001831 substrate-Mg2+ binding site; other site 552526001832 catalytic residues [active] 552526001833 aspartate-rich region 1; other site 552526001834 active site lid residues [active] 552526001835 aspartate-rich region 2; other site 552526001836 Predicted rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: COG1189 552526001837 S4 RNA-binding domain; Region: S4; smart00363 552526001838 FtsJ-like methyltransferase; Region: FtsJ; pfam01728 552526001839 Arginine repressor [Transcription]; Region: ArgR; COG1438 552526001840 Arginine repressor, DNA binding domain; Region: Arg_repressor; pfam01316 552526001841 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: RecN; COG0497 552526001842 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 552526001843 Walker A/P-loop; other site 552526001844 ATP binding site [chemical binding]; other site 552526001845 Q-loop/lid; other site 552526001846 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 552526001847 Q-loop/lid; other site 552526001848 ABC transporter signature motif; other site 552526001849 Walker B; other site 552526001850 D-loop; other site 552526001851 H-loop/switch region; other site 552526001852 EDD domain protein, DegV family; Region: DegV; TIGR00762 552526001853 Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645 552526001854 Members of the SGNH-hydrolase superfamily, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase_YpmR_like; cd04506 552526001855 active site 552526001856 catalytic triad [active] 552526001857 oxyanion hole [active] 552526001858 Uncharacterized protein conserved in bacteria (DUF2140); Region: DUF2140; cl11548 552526001859 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 552526001860 IHF dimer interface [polypeptide binding]; other site 552526001861 IHF - DNA interface [nucleotide binding]; other site 552526001862 ADP-ribosyltransferase exoenzyme; Region: ADPrib_exo_Tox; pfam03496 552526001863 active site 552526001864 conformational flexibility of ligand binding pocket; other site 552526001865 ADP-ribosylating toxin turn-turn motif; other site 552526001866 H+ Antiporter protein; Region: 2A0121; TIGR00900 552526001867 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cl17904 552526001868 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 552526001869 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 552526001870 non-specific DNA binding site [nucleotide binding]; other site 552526001871 salt bridge; other site 552526001872 sequence-specific DNA binding site [nucleotide binding]; other site 552526001873 transcriptional activator, Rgg/GadR/MutR family, C-terminal domain; Region: RGG_Cterm; TIGR01716 552526001874 Dihydroorotate dehydrogenase (DHOD) class 1A FMN-binding domain. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine...; Region: DHOD_1A_like; cd04741 552526001875 dihydroorotate dehydrogenase (subfamily 1) family protein; Region: pyrD_sub1_fam; TIGR01037 552526001876 active site 552526001877 FMN binding site [chemical binding]; other site 552526001878 substrate binding site [chemical binding]; other site 552526001879 catalytic residues [active] 552526001880 homodimer interface [polypeptide binding]; other site 552526001881 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 552526001882 catalytic core [active] 552526001883 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 552526001884 Predicted small molecule binding protein (contains 3H domain) [General function prediction only]; Region: COG1827 552526001885 HTH domain; Region: HTH_11; pfam08279 552526001886 3H domain; Region: 3H; pfam02829 552526001887 Formate/nitrite family of transporters [Inorganic ion transport and metabolism]; Region: FocA; COG2116 552526001888 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 552526001889 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 552526001890 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 552526001891 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 552526001892 recombination protein RecR; Reviewed; Region: recR; PRK00076 552526001893 RecR protein; Region: RecR; pfam02132 552526001894 TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR. RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025 552526001895 putative active site [active] 552526001896 putative metal-binding site [ion binding]; other site 552526001897 tetramer interface [polypeptide binding]; other site 552526001898 D-alanyl-alanine synthetase A; Reviewed; Region: ddl; PRK01966 552526001899 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 552526001900 ATP-grasp domain; Region: ATP-grasp_4; cl17255 552526001901 UDP-N-acetylmuramyl pentapeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurF; COG0770 552526001902 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 552526001903 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 552526001904 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 552526001905 conserved hypothetical integral membrane protein TIGR02206; Region: intg_mem_TP0381 552526001906 peptide chain release factor 3; Provisional; Region: prfC; PRK00741 552526001907 Release Factor 3 (RF3) protein involved in the terminal step of translocation in bacteria; Region: RF3; cd04169 552526001908 G1 box; other site 552526001909 putative GEF interaction site [polypeptide binding]; other site 552526001910 GTP/Mg2+ binding site [chemical binding]; other site 552526001911 Switch I region; other site 552526001912 G2 box; other site 552526001913 G3 box; other site 552526001914 Switch II region; other site 552526001915 G4 box; other site 552526001916 G5 box; other site 552526001917 RF3_II: this subfamily represents the domain II of bacterial Release Factor 3 (RF3). Termination of protein synthesis by the ribosome requires two release factor (RF) classes. The class II RF3 is a GTPase that removes class I RFs (RF1 or RF2) from the...; Region: RF3_II; cd03689 552526001918 ATP-dependent RNA helicase SrmB; Provisional; Region: PRK11192 552526001919 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 552526001920 ATP binding site [chemical binding]; other site 552526001921 Mg++ binding site [ion binding]; other site 552526001922 motif III; other site 552526001923 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 552526001924 nucleotide binding region [chemical binding]; other site 552526001925 ATP-binding site [chemical binding]; other site 552526001926 K+ potassium transporter; Region: K_trans; cl15781 552526001927 The GIY-YIG domain of uncharacterized protein family UPF0213 related to structure-specific endonuclease SLX1; Region: GIY-YIG_UPF0213; cd10456 552526001928 GIY-YIG motif/motif A; other site 552526001929 putative active site [active] 552526001930 putative metal binding site [ion binding]; other site 552526001931 Predicted O-methyltransferase [General function prediction only]; Region: COG4123 552526001932 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 552526001933 S-adenosylmethionine binding site [chemical binding]; other site 552526001934 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 552526001935 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 552526001936 putative acyl-acceptor binding pocket; other site 552526001937 SLBB domain; Region: SLBB; pfam10531 552526001938 comEA protein; Region: comE; TIGR01259 552526001939 RelA- and SpoT-like ppGpp Synthetases and Hydrolases, catalytic domain; Region: Rel-Spo_like; cl11966 552526001940 Predicted membrane metal-binding protein [General function prediction only]; Region: ComEC; COG0658 552526001941 Competence protein; Region: Competence; pfam03772 552526001942 Predicted hydrolase (metallo-beta-lactamase superfamily) [General function prediction only]; Region: ComEC; COG2333 552526001943 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 552526001944 DNA polymerase III subunit delta; Reviewed; Region: holA; PRK05574 552526001945 DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144 552526001946 Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605 552526001947 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 552526001948 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 552526001949 Protein of unknown function (DUF3114); Region: DUF3114; pfam11311 552526001950 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363 552526001951 GlcN6P_deaminase: Glucosamine-6-phosphate (GlcN6P) deaminase subfamily; GlcN6P deaminase catalyzes the reversible conversion of GlcN6P to D-fructose-6-phosphate (Fru6P) and ammonium. The reaction is an aldo-keto isomerization coupled with an amination or...; Region: GlcN6P_deaminase; cd01399 552526001952 active site 552526001953 trimer interface [polypeptide binding]; other site 552526001954 allosteric site; other site 552526001955 active site lid [active] 552526001956 hexamer (dimer of trimers) interface [polypeptide binding]; other site 552526001957 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 552526001958 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 552526001959 RNA binding surface [nucleotide binding]; other site 552526001960 Pseudouridine synthase, Escherichia coli RsuA like; Region: PseudoU_synth_RsuA; cd02553 552526001961 active site 552526001962 uracil binding [chemical binding]; other site 552526001963 Competence protein CoiA-like family; Region: CoiA; cl11541 552526001964 Oligoendopeptidase F [Amino acid transport and metabolism]; Region: COG1164 552526001965 Peptidase family M3B Oligopeptidase F (PepF); Region: M3B_PepF_3; cd09608 552526001966 active site 552526001967 Zn binding site [ion binding]; other site 552526001968 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 552526001969 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 552526001970 Coenzyme A binding pocket [chemical binding]; other site 552526001971 haloacid dehalogenase-like hydrolase; Region: Hydrolase; pfam00702 552526001972 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 552526001973 motif II; other site 552526001974 beta-phosphoglucomutase family hydrolase; Region: PGMB-YQAB-SF; TIGR02009 552526001975 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 552526001976 motif II; other site 552526001977 Predicted O-methyltransferase [General function prediction only]; Region: COG4122 552526001978 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 552526001979 S-adenosylmethionine binding site [chemical binding]; other site 552526001980 foldase protein PrsA; Reviewed; Region: PRK12450 552526001981 PPIC-type PPIASE domain; Region: Rotamase_2; pfam13145 552526001982 alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252 552526001983 Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673 552526001984 motif 1; other site 552526001985 active site 552526001986 motif 2; other site 552526001987 motif 3; other site 552526001988 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 552526001989 DHHA1 domain; Region: DHHA1; pfam02272 552526001990 DNA/RNA non-specific endonuclease; Region: Endonuclea_NS_2; cl17626 552526001991 DNA/RNA non-specific endonuclease; Region: Endonuclease_NS; smart00892 552526001992 delta-lactam-biosynthetic de-N-acetylase; Region: spore_pdaA; TIGR02884 552526001993 Catalytic NodB homology domain of Streptococcus pneumoniae peptidoglycan deacetylase PgdA, Bacillus subtilis BsYjeA protein, and their bacterial homologs; Region: CE4_SpPgdA_BsYjeA_like; cd10947 552526001994 NodB motif; other site 552526001995 active site 552526001996 catalytic site [active] 552526001997 Zn binding site [ion binding]; other site 552526001998 Superfamily II DNA and RNA helicases [DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis]; Region: SrmB; COG0513 552526001999 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 552526002000 ATP binding site [chemical binding]; other site 552526002001 putative Mg++ binding site [ion binding]; other site 552526002002 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 552526002003 nucleotide binding region [chemical binding]; other site 552526002004 ATP-binding site [chemical binding]; other site 552526002005 Uridine kinase [Nucleotide transport and metabolism]; Region: Udk; COG0572 552526002006 Uridine monophosphate kinase (UMPK, EC 2.7.1.48), also known as uridine kinase or uridine-cytidine kinase (UCK), catalyzes the reversible phosphoryl transfer from ATP to uridine or cytidine to yield UMP or CMP. In the primidine nucleotide-salvage pathway; Region: UMPK; cd02023 552526002007 Sugar specificity; other site 552526002008 Pyrimidine base specificity; other site 552526002009 ATP-binding site [chemical binding]; other site 552526002010 Predicted membrane protein [Function unknown]; Region: COG3326 552526002011 Protease prsW family; Region: PrsW-protease; pfam13367 552526002012 GAF domain-containing protein [Signal transduction mechanisms]; Region: COG1956 552526002013 DNA polymerase III subunits gamma and tau; Validated; Region: PRK05563 552526002014 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 552526002015 Walker A motif; other site 552526002016 ATP binding site [chemical binding]; other site 552526002017 Walker B motif; other site 552526002018 arginine finger; other site 552526002019 DNA polymerase III subunits gamma and tau domain III; Region: DNA_pol3_gamma3; pfam12169 552526002020 Protein of unknown function (DUF3272); Region: DUF3272; pfam11676 552526002021 bifunctional biotin--[acetyl-CoA-carboxylase] synthetase/biotin operon repressor; Provisional; Region: PRK11886 552526002022 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 552526002023 dimerization interface [polypeptide binding]; other site 552526002024 putative DNA binding site [nucleotide binding]; other site 552526002025 putative Zn2+ binding site [ion binding]; other site 552526002026 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; pfam03099 552526002027 Biotin protein ligase C terminal domain; Region: BPL_C; pfam02237 552526002028 streptococcal histidine triad protein; Region: strep_his_triad; TIGR01363 552526002029 Streptococcal histidine triad protein; Region: Strep_his_triad; pfam04270 552526002030 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 552526002031 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 552526002032 Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond...; Region: LRR_RI; cl15309 552526002033 Substrate binding site [chemical binding]; other site 552526002034 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 552526002035 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 552526002036 S-adenosylmethionine synthetase; Validated; Region: PRK05250 552526002037 S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438 552526002038 S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772 552526002039 S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773 552526002040 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 552526002041 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 552526002042 hinge; other site 552526002043 active site 552526002044 MFS/sugar transport protein; Region: MFS_2; pfam13347 552526002045 melibiose:sodium symporter; Provisional; Region: PRK10429; cl15392 552526002046 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 552526002047 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166 552526002048 substrate binding site [chemical binding]; other site 552526002049 ATP binding site [chemical binding]; other site 552526002050 beta-D-glucuronidase; Provisional; Region: PRK10150 552526002051 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837 552526002052 Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703 552526002053 Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836 552526002054 Transcriptional regulators [Transcription]; Region: FadR; COG2186 552526002055 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 552526002056 DNA-binding site [nucleotide binding]; DNA binding site 552526002057 FCD domain; Region: FCD; pfam07729 552526002058 2-keto-3-deoxy-6-phosphogluconate aldolase [Carbohydrate transport and metabolism]; Region: Eda; COG0800 552526002059 KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452 552526002060 active site 552526002061 intersubunit interface [polypeptide binding]; other site 552526002062 catalytic residue [active] 552526002063 Glucuronate isomerase; Region: UxaC; pfam02614 552526002064 Glucuronate isomerase [Carbohydrate transport and metabolism]; Region: UxaC; COG1904 552526002065 mannonate dehydratase; Provisional; Region: PRK03906 552526002066 mannonate dehydratase; Region: uxuA; TIGR00695 552526002067 D-mannonate oxidoreductase; Provisional; Region: PRK08277 552526002068 putative D-mannonate oxidoreductase, classical (c) SDR; Region: mannonate_red_SDR_c; cd08935 552526002069 putative NAD(P) binding site [chemical binding]; other site 552526002070 active site 552526002071 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 552526002072 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 552526002073 motif II; other site 552526002074 YSIRK type signal peptide; Region: YSIRK_signal; cl04650 552526002075 B domain; Region: IgG_binding_B; pfam01378 552526002076 B domain; Region: IgG_binding_B; pfam01378 552526002077 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 552526002078 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 552526002079 Predicted transcriptional regulator containing CBS domains [Transcription]; Region: COG4109 552526002080 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 552526002081 DNA-binding site [nucleotide binding]; DNA binding site 552526002082 DRTGG domain; Region: DRTGG; pfam07085 552526002083 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with a DRTGG domain upstream. The function of the DRTGG domain, named after its conserved residues, is unknown. CBS is a small domain originally...; Region: CBS_pair_DRTGG_assoc; cd04596 552526002084 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cd03440 552526002085 active site 2 [active] 552526002086 active site 1 [active] 552526002087 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 552526002088 active site 552526002089 Ribonuclease BN family enzyme [Replication, recombination, and repair]; Region: Rbn; COG1295 552526002090 3-phosphoshikimate 1-carboxyvinyltransferase; Provisional; Region: PRK02427 552526002091 EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556 552526002092 hinge; other site 552526002093 active site 552526002094 shikimate kinase; Reviewed; Region: aroK; PRK00131 552526002095 Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464 552526002096 ADP binding site [chemical binding]; other site 552526002097 magnesium binding site [ion binding]; other site 552526002098 putative shikimate binding site; other site 552526002099 Transcriptional regulator [Transcription]; Region: LytR; COG1316 552526002100 SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase [Translation, ribosomal structure and biogenesis]; Region: TrmA; COG2265 552526002101 TRAM domain; Region: TRAM; pfam01938 552526002102 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 552526002103 S-adenosylmethionine binding site [chemical binding]; other site 552526002104 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 552526002105 catalytic core [active] 552526002106 hypothetical protein; Provisional; Region: PRK11770 552526002107 Domain of unknown function (DUF307); Region: DUF307; pfam03733 552526002108 Domain of unknown function (DUF307); Region: DUF307; pfam03733 552526002109 This CD includes cysteinyl-tRNA(Pro) deacylases from Haemophilus influenzae and Escherichia coli and other related bacterial proteins. These trans-acting, single-domain proteins are homologs of ProX and also the cis-acting prolyl-tRNA synthetase (ProRS)...; Region: YbaK_deacylase; cd00002 552526002110 putative deacylase active site [active] 552526002111 Thiamine transporter protein (Thia_YuaJ); Region: Thia_YuaJ; cl17491 552526002112 Lyzozyme M1 (1,4-beta-N-acetylmuramidase) [Cell envelope biogenesis, outer membrane]; Region: Acm; COG3757 552526002113 PlyB is a bacteriophage endolysin that displays potent lytic activity toward Bacillus anthracis. PlyB has an N-terminal glycosyl hydrolase family 25 (GH25) catalytic domain and a C-terminal bacterial SH3-like domain, SH3b. Both domains are required for...; Region: GH25_PlyB-like; cd06523 552526002114 active site 552526002115 Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per...; Region: GSH_Peroxidase; cd00340 552526002116 catalytic residues [active] 552526002117 dimer interface [polypeptide binding]; other site 552526002118 oligoendopeptidase F; Region: pepF; TIGR00181 552526002119 Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins); Region: GluZincin; cl14813 552526002120 Zn binding site [ion binding]; other site 552526002121 phosphoenolpyruvate carboxylase; Reviewed; Region: PRK00009 552526002122 Phosphoenolpyruvate carboxylase [Energy production and conversion]; Region: Ppc; COG2352 552526002123 Bacterial cell division membrane protein [Cell division and chromosome partitioning]; Region: FtsW; COG0772 552526002124 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 552526002125 sequence-specific DNA binding site [nucleotide binding]; other site 552526002126 salt bridge; other site 552526002127 transcriptional activator, Rgg/GadR/MutR family, C-terminal domain; Region: RGG_Cterm; TIGR01716 552526002128 Radical SAM superfamily; Region: Radical_SAM; pfam04055 552526002129 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 552526002130 FeS/SAM binding site; other site 552526002131 Domain of unknown function (DUF4008); Region: DUF4008; cl14869 552526002132 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 552526002133 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 552526002134 ATP-binding cassette domain of multidrug resistance protein-like transporters; Region: ABCC_MRP_Like; cd03228 552526002135 Walker A/P-loop; other site 552526002136 ATP binding site [chemical binding]; other site 552526002137 Q-loop/lid; other site 552526002138 ABC transporter signature motif; other site 552526002139 Walker B; other site 552526002140 D-loop; other site 552526002141 H-loop/switch region; other site 552526002142 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 552526002143 ATP-binding cassette domain of multidrug resistance protein-like transporters; Region: ABCC_MRP_Like; cd03228 552526002144 Walker A/P-loop; other site 552526002145 ATP binding site [chemical binding]; other site 552526002146 Q-loop/lid; other site 552526002147 ABC transporter signature motif; other site 552526002148 Walker B; other site 552526002149 D-loop; other site 552526002150 H-loop/switch region; other site 552526002151 peptide chain release factor 2; Validated; Region: prfB; PRK00578 552526002152 PCRF domain; Region: PCRF; pfam03462 552526002153 RF-1 domain; Region: RF-1; pfam00472 552526002154 Predicted ATPase involved in cell division [Cell division and chromosome partitioning]; Region: FtsE; COG2884 552526002155 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 552526002156 Walker A/P-loop; other site 552526002157 ATP binding site [chemical binding]; other site 552526002158 Q-loop/lid; other site 552526002159 ABC transporter signature motif; other site 552526002160 Walker B; other site 552526002161 D-loop; other site 552526002162 H-loop/switch region; other site 552526002163 Cell division protein [Cell division and chromosome partitioning]; Region: FtsX; COG2177 552526002164 cell division ABC transporter subunit FtsX; Provisional; Region: ftsX; PRK11026 552526002165 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 552526002166 bifunctional ATP-dependent DNA helicase/DNA polymerase III subunit epsilon; Validated; Region: PRK07246 552526002167 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 552526002168 active site 552526002169 catalytic site [active] 552526002170 substrate binding site [chemical binding]; other site 552526002171 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 552526002172 ATP binding site [chemical binding]; other site 552526002173 Helicase C-terminal domain; Region: Helicase_C_2; pfam13307 552526002174 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5353 552526002175 aspartate aminotransferase; Provisional; Region: PRK05764 552526002176 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 552526002177 pyridoxal 5'-phosphate binding site [chemical binding]; other site 552526002178 homodimer interface [polypeptide binding]; other site 552526002179 catalytic residue [active] 552526002180 asparaginyl-tRNA synthetase; Validated; Region: asnC; PRK03932 552526002181 AsnRS_cyto_like_N: N-terminal, anticodon recognition domain of the type found in human and Saccharomyces cerevisiae cytoplasmic asparaginyl-tRNA synthetase (AsnRS), in Brugia malayai AsnRs and, in various putative bacterial AsnRSs. This domain is a...; Region: AsnRS_cyto_like_N; cd04323 552526002182 putative dimer interface [polypeptide binding]; other site 552526002183 putative anticodon binding site; other site 552526002184 Asx tRNA synthetase (AspRS/AsnRS) class II core domain. Assignment to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs in the core domain. This family includes AsnRS as well as...; Region: AsxRS_core; cd00776 552526002185 homodimer interface [polypeptide binding]; other site 552526002186 motif 1; other site 552526002187 motif 2; other site 552526002188 active site 552526002189 motif 3; other site 552526002190 Collagen triple helix repeat (20 copies); Region: Collagen; pfam01391 552526002191 glmZ(sRNA)-inactivating NTPase; Provisional; Region: PRK05416 552526002192 AAA domain; Region: AAA_33; pfam13671 552526002193 conserved hypothetical protein, cofD-related; Region: CofD_related; TIGR01826 552526002194 Family of CofD-like proteins and proteins related to YvcK; Region: CofD_YvcK; cd07044 552526002195 dimer interface [polypeptide binding]; other site 552526002196 phosphate binding site [ion binding]; other site 552526002197 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1481 552526002198 Sporulation Regulator WhiA N terminal; Region: WhiA_N; pfam10298 552526002199 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 552526002200 InsA N-terminal domain; Region: Zn_Tnp_IS1; pfam03811 552526002201 InsA C-terminal domain; Region: HTH_Tnp_IS1; pfam12759 552526002202 IS1 transposase; Region: DDE_Tnp_IS1; pfam03400 552526002203 Peptidase family C69; Region: Peptidase_C69; pfam03577 552526002204 ABC-type metal ion transport system, periplasmic component/surface adhesin [Inorganic ion transport and metabolism]; Region: LraI; COG0803 552526002205 Metal binding protein AcdA. These proteins have been shown to function in the ABC uptake of Zn2+ and Mn2+ and in competence for genetic transformation and adhesion. The AcdA proteins belong to the TroA superfamily of helical backbone metal receptor...; Region: AdcA; cd01017 552526002206 metal binding site [ion binding]; metal-binding site 552526002207 YodA lipocalin-like domain; Region: YodA; pfam09223 552526002208 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 552526002209 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 552526002210 DNA-binding site [nucleotide binding]; DNA binding site 552526002211 UTRA domain; Region: UTRA; pfam07702 552526002212 putative sugar isomerase, AgaS family; Region: agaS_fam; TIGR02815 552526002213 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 552526002214 dimer interface [polypeptide binding]; other site 552526002215 active site 552526002216 AgaS-like protein. AgaS contains a SIS (Sugar ISomerase) domain which is found in many phosphosugar isomerases and phosphosugar binding proteins. AgaS is a putative isomerase in Escherichia coli. It is similar to the glucosamine-6-phosphate synthases; Region: SIS_AgaS_like; cd05010 552526002217 putative active site [active] 552526002218 tagatose 1,6-diphosphate aldolase; Reviewed; Region: PRK04161 552526002219 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 552526002220 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 552526002221 DNA-binding site [nucleotide binding]; DNA binding site 552526002222 The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; Region: UTRA; smart00866 552526002223 Beta-galactosidase [Carbohydrate transport and metabolism]; Region: LacA; COG1874 552526002224 Glycosyl hydrolases family 35; Region: Glyco_hydro_35; pfam01301 552526002225 PTS_IIB, PTS system, Mannose/sorbose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_man; cd00001 552526002226 active site 552526002227 phosphorylation site [posttranslational modification] 552526002228 Phosphotransferase system, mannose/fructose/N-acetylgalactosamine-specific component IIC [Carbohydrate transport and metabolism]; Region: ManY; COG3715 552526002229 PTS system mannose/fructose/sorbose family IID component; Region: EIID-AGA; pfam03613 552526002230 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006 552526002231 active pocket/dimerization site; other site 552526002232 active site 552526002233 phosphorylation site [posttranslational modification] 552526002234 50S ribosomal protein L31 type B; Reviewed; Region: rpmE2; PRK01678 552526002235 Exopolyphosphatase-related proteins [General function prediction only]; Region: COG0618 552526002236 DHH family; Region: DHH; pfam01368 552526002237 DHHA1 domain; Region: DHHA1; pfam02272 552526002238 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 552526002239 Coenzyme A binding pocket [chemical binding]; other site 552526002240 Adenosine deaminase [Nucleotide transport and metabolism]; Region: Add; COG1816 552526002241 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 552526002242 active site 552526002243 flavodoxin; Validated; Region: PRK07308 552526002244 hypothetical protein; Provisional; Region: PRK07248 552526002245 CLC voltage-gated chloride channel. The ClC chloride channels catalyse the selective flow of Cl- ions across cell membranes, thereby regulating electrical excitation in skeletal muscle and the flow of salt and water across epithelial barriers. This...; Region: Voltage_gated_ClC; cl02915 552526002246 CLC voltage-gated chloride channel. The ClC chloride channels catalyse the selective flow of Cl- ions across cell membranes, thereby regulating electrical excitation in skeletal muscle and the flow of salt and water across epithelial barriers. This...; Region: Voltage_gated_ClC; cl02915 552526002247 Cl- selectivity filter; other site 552526002248 Cl- binding residues [ion binding]; other site 552526002249 Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038 552526002250 pore gating glutamate residue; other site 552526002251 dimer interface [polypeptide binding]; other site 552526002252 50S ribosomal protein L19; Provisional; Region: rplS; PRK05338 552526002253 DNA/RNA non-specific endonuclease; Region: Endonuclease_NS; smart00892 552526002254 DNA/RNA non-specific endonuclease; Region: Endonuclea_NS_2; cl17626 552526002255 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 552526002256 non-specific DNA binding site [nucleotide binding]; other site 552526002257 salt bridge; other site 552526002258 sequence-specific DNA binding site [nucleotide binding]; other site 552526002259 Protein of unknown function (DUF3169); Region: DUF3169; pfam11368 552526002260 Putative ClC chloride channel. Clc proteins are putative halogen ion (Cl-, Br- and I-) transporters found in eubacteria. They belong to the ClC superfamily of halogen ion channels, which share a unique double-barreled architecture and voltage-dependent...; Region: ClC_like; cd01033 552526002261 putative ion selectivity filter; other site 552526002262 Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038 552526002263 putative pore gating glutamate residue; other site 552526002264 ribonucleotide-diphosphate reductase subunit beta; Provisional; Region: nrdF2; PRK13966 552526002265 Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049 552526002266 dimer interface [polypeptide binding]; other site 552526002267 putative radical transfer pathway; other site 552526002268 diiron center [ion binding]; other site 552526002269 tyrosyl radical; other site 552526002270 NrdH-redoxin (NrdH) family; NrdH is a small monomeric protein with a conserved redox active CXXC motif within a TRX fold, characterized by a glutaredoxin (GRX)-like sequence and TRX-like activity profile. In vitro, it displays protein disulfide reductase...; Region: NrdH; cd02976 552526002271 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 552526002272 dimerization domain swap beta strand [polypeptide binding]; other site 552526002273 regulatory protein interface [polypeptide binding]; other site 552526002274 active site 552526002275 regulatory phosphorylation site [posttranslational modification]; other site 552526002276 Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism]; Region: PtsA; COG1080 552526002277 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 552526002278 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 552526002279 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 552526002280 NADP+-dependent non-phosphorylating glyceraldehyde 3-phosphate dehydrogenase and ALDH family 11; Region: ALDH_F11_NP-GAPDH; cd07082 552526002281 NADP-dependent glyceraldehyde-3-phosphate dehydrogenase; Provisional; Region: PLN00412 552526002282 tetrameric interface [polypeptide binding]; other site 552526002283 activator binding site; other site 552526002284 NADP binding site [chemical binding]; other site 552526002285 substrate binding site [chemical binding]; other site 552526002286 catalytic residues [active] 552526002287 Bacterial cell division membrane protein [Cell division and chromosome partitioning]; Region: FtsW; COG0772 552526002288 haloacid dehalogenase superfamily, subfamily IA, variant 1 with third motif having Dx(3-4)D or Dx(3-4)E; Region: HAD-SF-IA-v1; TIGR01549 552526002289 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 552526002290 motif II; other site 552526002291 DNA gyrase subunit B; Validated; Region: gyrB; PRK05644 552526002292 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 552526002293 Mg2+ binding site [ion binding]; other site 552526002294 G-X-G motif; other site 552526002295 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 552526002296 anchoring element; other site 552526002297 dimer interface [polypeptide binding]; other site 552526002298 ATP binding site [chemical binding]; other site 552526002299 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 552526002300 active site 552526002301 putative metal-binding site [ion binding]; other site 552526002302 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 552526002303 septation ring formation regulator EzrA; Provisional; Region: PRK04778 552526002304 Protein of unknown function (DUF1694); Region: DUF1694; cl02318 552526002305 enolase; Provisional; Region: eno; PRK00077 552526002306 Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313 552526002307 dimer interface [polypeptide binding]; other site 552526002308 metal binding site [ion binding]; metal-binding site 552526002309 substrate binding pocket [chemical binding]; other site 552526002310 Cytotoxic translational repressor of toxin-antitoxin stability system [Translation, ribosomal structure and biogenesis / Cell division and chromosome partitioning]; Region: RelE; COG2026 552526002311 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 552526002312 Transposase; Region: HTH_Tnp_1; cl17663 552526002313 HTH-like domain; Region: HTH_21; pfam13276 552526002314 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 552526002315 Predicted hydrolase (HAD superfamily) [General function prediction only]; Region: COG1011 552526002316 Predicted extracellular nuclease [General function prediction only]; Region: COG2374 552526002317 YhcR_OBF_like: A subfamily of OB-fold domains similar to the OB folds of Bacillus subtilis YhcR. YhcR is a sugar-nonspecific nuclease, which is active in the presence of Ca2+ and Mn2+. It cleaves RNA endonucleolytically, producing 3'-monophosphate...; Region: YhcR_OBF_like; cd04486 552526002318 generic binding surface II; other site 552526002319 generic binding surface I; other site 552526002320 YhcR_OBF_like: A subfamily of OB-fold domains similar to the OB folds of Bacillus subtilis YhcR. YhcR is a sugar-nonspecific nuclease, which is active in the presence of Ca2+ and Mn2+. It cleaves RNA endonucleolytically, producing 3'-monophosphate...; Region: YhcR_OBF_like; cd04486 552526002321 generic binding surface I; other site 552526002322 generic binding surface II; other site 552526002323 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 552526002324 putative catalytic site [active] 552526002325 putative metal binding site [ion binding]; other site 552526002326 putative phosphate binding site [ion binding]; other site 552526002327 Predicted membrane protein [Function unknown]; Region: COG4708 552526002328 NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956 552526002329 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114 552526002330 nucleotide binding pocket [chemical binding]; other site 552526002331 K-X-D-G motif; other site 552526002332 catalytic site [active] 552526002333 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 552526002334 NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119 552526002335 Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027 552526002336 Dimer interface [polypeptide binding]; other site 552526002337 BRCT sequence motif; other site 552526002338 putative lipid kinase; Reviewed; Region: PRK13055 552526002339 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 552526002340 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; cl17465 552526002341 Family 41 Carbohydrate-Binding Module from pullulanase-like enzymes; Region: CBM41_pullulanase; cd10315 552526002342 carbohydrate binding site [chemical binding]; other site 552526002343 pullulanase, type I; Region: pulA_typeI; TIGR02104 552526002344 Early set domain associated with the catalytic domain of pullulanase (also called dextrinase and alpha-dextrin endo-1,6-alpha glucosidase); Region: E_set_Pullulanase; cd02860 552526002345 Alpha amylase catalytic domain found in Pullulanase (also called dextrinase; alpha-dextrin endo-1,6-alpha glucosidase), limit dextrinase, and related proteins; Region: AmyAc_Pullulanase_LD-like; cd11341 552526002346 Ca binding site [ion binding]; other site 552526002347 active site 552526002348 catalytic site [active] 552526002349 glycogen branching enzyme; Provisional; Region: PRK12313 552526002350 N-terminal Early set domain associated with the catalytic domain of prokaryotic glycogen branching enzyme; Region: E_set_GBE_prok_N; cd02855 552526002351 Alpha amylase catalytic domain found in the Glycogen branching enzyme (also called 1,4-alpha-glucan branching enzyme); Region: AmyAc_Glg_BE; cd11322 552526002352 active site 552526002353 catalytic site [active] 552526002354 Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; pfam02806 552526002355 glucose-1-phosphate adenylyltransferase; Provisional; Region: glgC; PRK05293 552526002356 ADP-glucose pyrophosphorylase is involved in the biosynthesis of glycogen or starch; Region: ADP_Glucose_PP; cd02508 552526002357 ligand binding site; other site 552526002358 oligomer interface; other site 552526002359 Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651 552526002360 dimer interface [polypeptide binding]; other site 552526002361 N-terminal domain interface [polypeptide binding]; other site 552526002362 sulfate 1 binding site; other site 552526002363 glucose-1-phosphate adenylyltransferase, GlgD subunit; Region: glgD; TIGR02092 552526002364 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 552526002365 active site 552526002366 Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651 552526002367 dimer interface [polypeptide binding]; other site 552526002368 N-terminal domain interface [polypeptide binding]; other site 552526002369 sulfate 1 binding site; other site 552526002370 This family is most closely related to the GT1 family of glycosyltransferases. Glycogen synthase catalyzes the formation and elongation of the alpha-1,4-glucose backbone using ADP-glucose, the second and key step of glycogen biosynthesis. This family...; Region: GT1_Glycogen_synthase_DULL1_like; cd03791 552526002371 glycogen synthase; Provisional; Region: glgA; PRK00654 552526002372 ADP-binding pocket [chemical binding]; other site 552526002373 homodimer interface [polypeptide binding]; other site 552526002374 This is a family of oligosaccharide phosphorylases. It includes yeast and mammalian glycogen phosphorylases, plant starch/glucan phosphorylase, as well as the maltodextrin phosphorylases of bacteria. The members of this family catalyze the breakdown of...; Region: GT1_Glycogen_Phosphorylase; cd04300 552526002375 homodimer interface [polypeptide binding]; other site 552526002376 glycogen/starch/alpha-glucan phosphorylases; Region: P_ylase; TIGR02093 552526002377 active site pocket [active] 552526002378 F0F1 ATP synthase subunit C; Provisional; Region: PRK13467 552526002379 F0F1-type ATP synthase, subunit a [Energy production and conversion]; Region: AtpB; COG0356 552526002380 F0F1 ATP synthase subunit A; Validated; Region: PRK05815 552526002381 F0F1-type ATP synthase, subunit b [Energy production and conversion]; Region: AtpF; COG0711 552526002382 F0F1 ATP synthase subunit B; Validated; Region: PRK05759 552526002383 F0F1 ATP synthase subunit delta; Validated; Region: PRK05758 552526002384 ATP synthase delta (OSCP) subunit; Region: OSCP; pfam00213 552526002385 F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281 552526002386 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 552526002387 F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132 552526002388 beta subunit interaction interface [polypeptide binding]; other site 552526002389 Walker A motif; other site 552526002390 ATP binding site [chemical binding]; other site 552526002391 Walker B motif; other site 552526002392 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 552526002393 mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151 552526002394 core domain interface [polypeptide binding]; other site 552526002395 delta subunit interface [polypeptide binding]; other site 552526002396 epsilon subunit interface [polypeptide binding]; other site 552526002397 F0F1 ATP synthase subunit beta; Validated; Region: PRK09280 552526002398 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 552526002399 F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133 552526002400 alpha subunit interaction interface [polypeptide binding]; other site 552526002401 Walker A motif; other site 552526002402 ATP binding site [chemical binding]; other site 552526002403 Walker B motif; other site 552526002404 inhibitor binding site; inhibition site 552526002405 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 552526002406 F0F1 ATP synthase subunit epsilon; Validated; Region: atpC; PRK00571 552526002407 mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152 552526002408 gamma subunit interface [polypeptide binding]; other site 552526002409 epsilon subunit interface [polypeptide binding]; other site 552526002410 LBP interface [polypeptide binding]; other site 552526002411 Protein of unknown function (DUF1146); Region: DUF1146; cl11486 552526002412 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 552526002413 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 552526002414 hinge; other site 552526002415 active site 552526002416 DNA-directed RNA polymerase subunit beta; Region: EpuA; pfam11772 552526002417 DNA/RNA non-specific endonuclease; Region: Endonuclease_NS; smart00892 552526002418 DNA/RNA non-specific endonuclease; Region: Endonuclea_NS_2; cl17626 552526002419 phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488 552526002420 Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912 552526002421 Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496 552526002422 dimer interface [polypeptide binding]; other site 552526002423 motif 1; other site 552526002424 active site 552526002425 motif 2; other site 552526002426 motif 3; other site 552526002427 phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629 552526002428 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 552526002429 putative tRNA-binding site [nucleotide binding]; other site 552526002430 B3/4 domain; Region: B3_4; pfam03483 552526002431 tRNA synthetase B5 domain; Region: B5; smart00874 552526002432 Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA, PheRS is an...; Region: PheRS_beta_core; cd00769 552526002433 dimer interface [polypeptide binding]; other site 552526002434 motif 1; other site 552526002435 motif 3; other site 552526002436 motif 2; other site 552526002437 Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; pfam03147 552526002438 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 552526002439 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 552526002440 FtsX-like permease family; Region: FtsX; pfam02687 552526002441 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 552526002442 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 552526002443 Walker A/P-loop; other site 552526002444 ATP binding site [chemical binding]; other site 552526002445 Q-loop/lid; other site 552526002446 ABC transporter signature motif; other site 552526002447 Walker B; other site 552526002448 D-loop; other site 552526002449 H-loop/switch region; other site 552526002450 probable dihydroxyacetone kinase regulator; Region: DHAK_reg; TIGR02366 552526002451 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 552526002452 Collagen binding domain; Region: Collagen_bind; pfam05737 552526002453 Repeat unit of collagen-binding protein domain B; Region: CollagenBindB; cd00222 552526002454 domain interaction interfaces [polypeptide binding]; other site 552526002455 Repeat unit of collagen-binding protein domain B; Region: CollagenBindB; cd00222 552526002456 domain interaction interfaces [polypeptide binding]; other site 552526002457 Repeat unit of collagen-binding protein domain B; Region: CollagenBindB; cd00222 552526002458 domain interaction interfaces [polypeptide binding]; other site 552526002459 fimbrial isopeptide formation D2 domain; Region: RrgB_K2N_iso_D2; TIGR04226 552526002460 Sortase C (SrtC) or subfamily-3 sortases are membrane cysteine transpeptidases found in Gram-positive bacteria that anchor surface proteins to peptidoglycans of the bacterial cell wall envelope. This involves a transpeptidation reaction in which the...; Region: Sortase_C_3; cd05827 552526002461 active site 552526002462 catalytic site [active] 552526002463 YSIRK type signal peptide; Region: YSIRK_signal; cl04650 552526002464 Mac 1; Region: Mac-1; pfam09028 552526002465 Gram-positive signal peptide, YSIRK family; Region: YSIRK_signal; TIGR01168 552526002466 pullulanase, extracellular, Gram-positive; Region: pullulan_Gpos; TIGR02102 552526002467 Family 41 Carbohydrate-Binding Module from pullulanase-like enzymes; Region: CBM41_pullulanase; cd10315 552526002468 carbohydrate binding site [chemical binding]; other site 552526002469 Family 41 Carbohydrate-Binding Module from pullulanase-like enzymes; Region: CBM41_pullulanase; cd10315 552526002470 carbohydrate binding site [chemical binding]; other site 552526002471 Early set domain associated with the catalytic domain of pullulanase (also called dextrinase and alpha-dextrin endo-1,6-alpha glucosidase); Region: E_set_Pullulanase; cd02860 552526002472 Alpha amylase catalytic domain found in Pullulanase (also called dextrinase; alpha-dextrin endo-1,6-alpha glucosidase), limit dextrinase, and related proteins; Region: AmyAc_Pullulanase_LD-like; cd11341 552526002473 Ca binding site [ion binding]; other site 552526002474 active site 552526002475 catalytic site [active] 552526002476 DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595 552526002477 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 552526002478 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 552526002479 DNA binding residues [nucleotide binding] 552526002480 Polyphosphate(polyP) polymerase domain of yeast vacuolar transport chaperone (VTC) proteins VTC-2, -3 and- 4, and similar proteins; Region: PolyPPase_VTC_like; cd07750 552526002481 putative metal binding residues [ion binding]; other site 552526002482 signature motif; other site 552526002483 dimer interface [polypeptide binding]; other site 552526002484 active site 552526002485 polyP binding site; other site 552526002486 substrate binding site [chemical binding]; other site 552526002487 acceptor-phosphate pocket; other site 552526002488 CotH protein; Region: CotH; pfam08757 552526002489 poly-beta-1,6 N-acetyl-D-glucosamine synthase; Region: PgaC_IcaA; TIGR03937 552526002490 CESA_like is the cellulose synthase superfamily; Region: CESA_like; cd06423 552526002491 DXD motif; other site 552526002492 ATP-dependent nuclease subunit B; Region: rexB_recomb; TIGR02774 552526002493 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 552526002494 helicase-exonuclease AddAB, AddA subunit, Firmicutes type; Region: addA_Gpos; TIGR02785 552526002495 Part of AAA domain; Region: AAA_19; pfam13245 552526002496 Family description; Region: UvrD_C_2; pfam13538 552526002497 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 552526002498 transaminase; Validated; Region: PRK07324 552526002499 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 552526002500 pyridoxal 5'-phosphate binding site [chemical binding]; other site 552526002501 homodimer interface [polypeptide binding]; other site 552526002502 catalytic residue [active] 552526002503 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 552526002504 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 552526002505 substrate binding pocket [chemical binding]; other site 552526002506 membrane-bound complex binding site; other site 552526002507 hinge residues; other site 552526002508 30S ribosomal protein S21; Reviewed; Region: rpsU; PRK00270 552526002509 Large-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscL; COG1970 552526002510 large-conductance mechanosensitive channel; Reviewed; Region: mscL; PRK00567 552526002511 DNA primase; Validated; Region: dnaG; PRK05667 552526002512 CHC2 zinc finger; Region: zf-CHC2; pfam01807 552526002513 DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275 552526002514 TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364 552526002515 active site 552526002516 metal binding site [ion binding]; metal-binding site 552526002517 interdomain interaction site; other site 552526002518 DnaB-helicase binding domain of primase; Region: DnaB_bind; pfam10410 552526002519 RNA polymerase sigma factor RpoD; Validated; Region: PRK09210 552526002520 Sigma-70 factor, region 1.1; Region: Sigma70_r1_1; pfam03979 552526002521 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 552526002522 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 552526002523 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 552526002524 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 552526002525 DNA binding residues [nucleotide binding] 552526002526 Predicted metal-sulfur cluster biosynthetic enzyme [General function prediction only]; Region: PaaD; COG2151 552526002527 dTDP-6-deoxy-L-lyxo-4-hexulose reductase and related proteins, extended (e) SDRs; Region: dTDP_HR_like_SDR_e; cd05254 552526002528 RmlD substrate binding domain; Region: RmlD_sub_bind; pfam04321 552526002529 NADP binding site [chemical binding]; other site 552526002530 active site 552526002531 putative substrate binding site [chemical binding]; other site 552526002532 This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_6; cd04955 552526002533 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 552526002534 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 552526002535 Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_d; cd04196 552526002536 Probable Catalytic site; other site 552526002537 ABC-type polysaccharide/polyol phosphate export systems, permease component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagG; COG1682 552526002538 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 552526002539 ABC-type polysaccharide/polyol phosphate transport system, ATPase component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagH; COG1134 552526002540 ATP-binding cassette component of polysaccharide transport system; Region: ABC_KpsT_Wzt; cd03220 552526002541 Walker A/P-loop; other site 552526002542 ATP binding site [chemical binding]; other site 552526002543 Q-loop/lid; other site 552526002544 ABC transporter signature motif; other site 552526002545 Walker B; other site 552526002546 D-loop; other site 552526002547 H-loop/switch region; other site 552526002548 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 552526002549 Glycosyl transferase family 2; Region: Glycos_transf_2; pfam00535 552526002550 active site 552526002551 Rhamnan synthesis protein F; Region: RgpF; pfam05045 552526002552 dolichyl-phosphate beta-D-mannosyltransferase; Region: PLN02726 552526002553 DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179 552526002554 Ligand binding site; other site 552526002555 Putative Catalytic site; other site 552526002556 DXD motif; other site 552526002557 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 552526002558 Polysaccharide biosynthesis protein; Region: Polysacc_synt_3; pfam13440 552526002559 Predicted membrane protein [Function unknown]; Region: COG4713 552526002560 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 552526002561 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 552526002562 Sulfatase; Region: Sulfatase; pfam00884 552526002563 UDP-glucose 4-epimerase; Region: PLN02240 552526002564 UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247 552526002565 NAD binding site [chemical binding]; other site 552526002566 homodimer interface [polypeptide binding]; other site 552526002567 active site 552526002568 substrate binding site [chemical binding]; other site 552526002569 M20 Peptidase T specifically cleaves tripeptides; Region: M20_peptT; cd03892 552526002570 metal binding site [ion binding]; metal-binding site 552526002571 dimer interface [polypeptide binding]; other site 552526002572 Ferredoxin [Energy production and conversion]; Region: Fer; COG1141 552526002573 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 552526002574 cytidylate kinase; Provisional; Region: cmk; PRK00023 552526002575 Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020 552526002576 CMP-binding site; other site 552526002577 The sites determining sugar specificity; other site 552526002578 translation initiation factor IF-3; Reviewed; Region: infC; PRK00028 552526002579 Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198 552526002580 Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707 552526002581 50S ribosomal protein L35; Reviewed; Region: rpmI; PRK00172 552526002582 Ribosomal protein L20; Region: Ribosomal_L20; cd07026 552526002583 23S rRNA binding site [nucleotide binding]; other site 552526002584 L21 binding site [polypeptide binding]; other site 552526002585 L13 binding site [polypeptide binding]; other site 552526002586 Phosphoglycerol transferase and related proteins, alkaline phosphatase superfamily [Cell envelope biogenesis, outer membrane]; Region: MdoB; COG1368 552526002587 Sulfatase; Region: Sulfatase; pfam00884 552526002588 Predicted SAM-dependent methyltransferases [General function prediction only]; Region: COG1092 552526002589 Middle domain of the SAM-dependent methyltransferase RlmI and related proteins; Region: RlmI_M_like; cd11572 552526002590 putative RNA binding site [nucleotide binding]; other site 552526002591 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 552526002592 S-adenosylmethionine binding site [chemical binding]; other site 552526002593 3-dehydroquinate dehydratase [Amino acid transport and metabolism]; Region: AroD; COG0710 552526002594 Type I 3-dehydroquinase, (3-dehydroquinate dehydratase or DHQase); Region: DHQase_I; cd00502 552526002595 active site 552526002596 catalytic residue [active] 552526002597 dimer interface [polypeptide binding]; other site 552526002598 Chorismate synthase [Amino acid transport and metabolism]; Region: AroC; COG0082 552526002599 Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304 552526002600 Tetramer interface [polypeptide binding]; other site 552526002601 active site 552526002602 FMN-binding site [chemical binding]; other site 552526002603 hypothetical protein; Provisional; Region: PRK13676 552526002604 glutathione reductase; Validated; Region: PRK06116 552526002605 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 552526002606 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 552526002607 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 552526002608 cytoskeletal protein RodZ; Provisional; Region: PRK10856 552526002609 Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104 552526002610 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 552526002611 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 552526002612 catalytic residue [active] 552526002613 thiamine biosynthesis protein ThiI; Provisional; Region: PRK01565 552526002614 THUMP domain of thiamine biosynthesis protein ThiI; Region: THUMP_ThiI; cd11716 552526002615 ThiI is required for thiazole synthesis in the thiamine biosynthesis pathway. It belongs to the Adenosine Nucleotide Hydrolysis suoerfamily and predicted to bind to Adenosine nucleotide; Region: ThiI; cd01712 552526002616 Ligand Binding Site [chemical binding]; other site 552526002617 Mac 1; Region: Mac-1; pfam09028 552526002618 DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; pfam13808 552526002619 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 552526002620 DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; cl17880 552526002621 Uncharacterized conserved protein [Function unknown]; Region: COG0398 552526002622 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 552526002623 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 552526002624 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 552526002625 Walker A/P-loop; other site 552526002626 ATP binding site [chemical binding]; other site 552526002627 Q-loop/lid; other site 552526002628 ABC transporter signature motif; other site 552526002629 Walker B; other site 552526002630 D-loop; other site 552526002631 H-loop/switch region; other site 552526002632 Predicted transcriptional regulators [Transcription]; Region: COG1725 552526002633 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 552526002634 DNA-binding site [nucleotide binding]; DNA binding site 552526002635 DNA polymerase III DnaE; Reviewed; Region: dnaE; PRK07279 552526002636 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III; Region: PHP_PolIIIA; cd07431 552526002637 active site 552526002638 PHP Thumb interface [polypeptide binding]; other site 552526002639 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 552526002640 generic binding surface II; other site 552526002641 generic binding surface I; other site 552526002642 Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to a subfamily of the PFKA family (cd00363) and include bacterial ATP-dependent...; Region: Bacterial_PFK; cd00763 552526002643 6-phosphofructokinase; Region: PFKA_ATP; TIGR02482 552526002644 active site 552526002645 ADP/pyrophosphate binding site [chemical binding]; other site 552526002646 dimerization interface [polypeptide binding]; other site 552526002647 allosteric effector site; other site 552526002648 fructose-1,6-bisphosphate binding site; other site 552526002649 pyruvate kinase; Provisional; Region: PRK05826 552526002650 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342 552526002651 domain interfaces; other site 552526002652 active site 552526002653 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 552526002654 The S24, S26 LexA/signal peptidase superfamily contains LexA-related and type I signal peptidase families. The S24 LexA protein domains include: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC 3.4.21.88), the...; Region: Peptidase_S24_S26; cl10465 552526002655 The S24, S26 LexA/signal peptidase superfamily contains LexA-related and type I signal peptidase families. The S24 LexA protein domains include: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC 3.4.21.88), the...; Region: Peptidase_S24_S26; cl10465 552526002656 glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331 552526002657 Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans). The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714 552526002658 glutaminase active site [active] 552526002659 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 552526002660 dimer interface [polypeptide binding]; other site 552526002661 active site 552526002662 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 552526002663 dimer interface [polypeptide binding]; other site 552526002664 active site 552526002665 Uncharacterized Zn-ribbon-containing protein involved in phosphonate metabolism [Inorganic ion transport and metabolism]; Region: PhnA; COG2824 552526002666 PhnA Zinc-Ribbon; Region: PhnA_Zn_Ribbon; pfam08274 552526002667 PhnA protein; Region: PhnA; pfam03831 552526002668 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 552526002669 dimer interface [polypeptide binding]; other site 552526002670 conserved gate region; other site 552526002671 ABC-ATPase subunit interface; other site 552526002672 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 552526002673 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 552526002674 Walker A/P-loop; other site 552526002675 ATP binding site [chemical binding]; other site 552526002676 Q-loop/lid; other site 552526002677 ABC transporter signature motif; other site 552526002678 Walker B; other site 552526002679 D-loop; other site 552526002680 H-loop/switch region; other site 552526002681 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 552526002682 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 552526002683 substrate binding pocket [chemical binding]; other site 552526002684 membrane-bound complex binding site; other site 552526002685 hinge residues; other site 552526002686 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 552526002687 Cation efflux family; Region: Cation_efflux; pfam01545 552526002688 Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115 552526002689 amino acid carrier protein; Region: agcS; TIGR00835 552526002690 ATP-dependent DNA helicase PcrA; Region: pcrA; TIGR01073 552526002691 Part of AAA domain; Region: AAA_19; pfam13245 552526002692 Family description; Region: UvrD_C_2; pfam13538 552526002693 Predicted membrane protein [Function unknown]; Region: COG2261 552526002694 Small integral membrane protein [Function unknown]; Region: COG5547 552526002695 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1302 552526002696 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1302 552526002697 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 552526002698 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 552526002699 DNA-binding site [nucleotide binding]; DNA binding site 552526002700 TrkA-C domain; Region: TrkA_C; pfam02080 552526002701 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 552526002702 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 552526002703 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 552526002704 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 552526002705 Walker A/P-loop; other site 552526002706 ATP binding site [chemical binding]; other site 552526002707 Q-loop/lid; other site 552526002708 ABC transporter signature motif; other site 552526002709 Walker B; other site 552526002710 D-loop; other site 552526002711 H-loop/switch region; other site 552526002712 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 552526002713 FtsX-like permease family; Region: FtsX; pfam02687 552526002714 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 552526002715 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 552526002716 FtsX-like permease family; Region: FtsX; pfam02687 552526002717 Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732 552526002718 Predicted membrane protein [Function unknown]; Region: COG4129 552526002719 Bacterial protein of unknown function (DUF939); Region: DUF939; pfam06081 552526002720 DUF939 C-terminal domain; Region: DUF939_C; pfam11728 552526002721 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4487 552526002722 Uncharacterized protein conserved in bacteria (DUF2130); Region: DUF2130; pfam09903 552526002723 tRNA pseudouridine synthase B; Provisional; Region: truB; PRK02484 552526002724 Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573 552526002725 RNA binding site [nucleotide binding]; other site 552526002726 active site 552526002727 bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627 552526002728 FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064 552526002729 active site 552526002730 Riboflavin kinase; Region: Flavokinase; pfam01687 552526002731 Arsenate Reductase (ArsC) family, Spx subfamily; Spx is a unique RNA polymerase (RNAP)-binding protein present in bacilli and some mollicutes. It inhibits transcription by binding to the C-terminal domain of the alpha subunit of RNAP, disrupting complex...; Region: ArsC_Spx; cd03032 552526002732 ArsC family; Region: ArsC; pfam03960 552526002733 putative catalytic residues [active] 552526002734 thiol/disulfide switch; other site 552526002735 hypothetical protein; Provisional; Region: PRK04387 552526002736 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 552526002737 Inositol-monophosphatase-like domains. This family of phosphatases is dependent on bivalent metal ions such as Mg++, and many members are inhibited by Li+ (which is thought to displace a bivalent ion in the active site). Substrates include fructose-1; Region: IMPase_like; cd01637 552526002738 active site 552526002739 rRNA (cytosine-C(5)-)-methyltransferase RsmF; Reviewed; Region: yebU; PRK11933 552526002740 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 552526002741 S-adenosylmethionine binding site [chemical binding]; other site 552526002742 pre-rRNA processing and ribosome biogenesis; Region: Nol1_Nop2_Fmu_2; pfam13636 552526002743 PBP superfamily domain; Region: PBP_like_2; cl17296 552526002744 ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstC; COG0573 552526002745 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 552526002746 dimer interface [polypeptide binding]; other site 552526002747 conserved gate region; other site 552526002748 putative PBP binding loops; other site 552526002749 ABC-ATPase subunit interface; other site 552526002750 ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstA; COG0581 552526002751 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 552526002752 dimer interface [polypeptide binding]; other site 552526002753 conserved gate region; other site 552526002754 putative PBP binding loops; other site 552526002755 ABC-ATPase subunit interface; other site 552526002756 phosphate transporter ATP-binding protein; Provisional; Region: PRK14237 552526002757 ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260 552526002758 Walker A/P-loop; other site 552526002759 ATP binding site [chemical binding]; other site 552526002760 Q-loop/lid; other site 552526002761 ABC transporter signature motif; other site 552526002762 Walker B; other site 552526002763 D-loop; other site 552526002764 H-loop/switch region; other site 552526002765 phosphate transporter ATP-binding protein; Provisional; Region: PRK14239 552526002766 ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260 552526002767 Walker A/P-loop; other site 552526002768 ATP binding site [chemical binding]; other site 552526002769 Q-loop/lid; other site 552526002770 ABC transporter signature motif; other site 552526002771 Walker B; other site 552526002772 D-loop; other site 552526002773 H-loop/switch region; other site 552526002774 phosphate transport system regulatory protein PhoU; Region: phoU_full; TIGR02135 552526002775 PhoU domain; Region: PhoU; pfam01895 552526002776 PhoU domain; Region: PhoU; pfam01895 552526002777 Peptidase M1 Aminopeptidase N family incudes tricorn interacting factor F3, Endoplasmic reticulum aminopeptidase 1 (ERAP1), Aminopeptidase Q (APQ); Region: M1_APN_2; cd09601 552526002778 Aminopeptidase N [Amino acid transport and metabolism]; Region: PepN; COG0308 552526002779 Zn binding site [ion binding]; other site 552526002780 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 552526002781 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 552526002782 active site 552526002783 phosphorylation site [posttranslational modification] 552526002784 intermolecular recognition site; other site 552526002785 dimerization interface [polypeptide binding]; other site 552526002786 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 552526002787 DNA binding site [nucleotide binding] 552526002788 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 552526002789 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 552526002790 dimer interface [polypeptide binding]; other site 552526002791 phosphorylation site [posttranslational modification] 552526002792 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 552526002793 ATP binding site [chemical binding]; other site 552526002794 Mg2+ binding site [ion binding]; other site 552526002795 G-X-G motif; other site 552526002796 Lipase. Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is "interfacial activation", the process of...; Region: Lipase; cl14883 552526002797 nucleophilic elbow; other site 552526002798 catalytic triad; other site 552526002799 30S ribosomal protein S20; Reviewed; Region: rpsT; PRK00239 552526002800 pantothenate kinase; Provisional; Region: PRK05439 552526002801 Pantothenate kinase (PanK) catalyzes the phosphorylation of pantothenic acid to form 4'-phosphopantothenic, which is the first of five steps in coenzyme A (CoA) biosynthetic pathway. The reaction carried out by this enzyme is a key regulatory point...; Region: PanK; cd02025 552526002802 ATP-binding site [chemical binding]; other site 552526002803 CoA-binding site [chemical binding]; other site 552526002804 Mg2+-binding site [ion binding]; other site 552526002805 16S RNA G1207 methylase RsmC [Translation, ribosomal structure and biogenesis]; Region: RsmC; COG2813 552526002806 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 552526002807 S-adenosylmethionine binding site [chemical binding]; other site 552526002808 pyrimidine-nucleoside phosphorylase; Reviewed; Region: PRK06078 552526002809 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 552526002810 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 552526002811 Pyrimidine nucleoside phosphorylase C-terminal domain; Region: PYNP_C; pfam07831 552526002812 2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family; Region: DeoC; cd00959 552526002813 intersubunit interface [polypeptide binding]; other site 552526002814 active site 552526002815 catalytic residue [active] 552526002816 Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283 552526002817 active site 552526002818 catalytic motif [active] 552526002819 Zn binding site [ion binding]; other site 552526002820 Uncharacterized ABC-type transport system, periplasmic component/surface lipoprotein [General function prediction only]; Region: Med; COG1744 552526002821 Periplasmic binding domain of basic membrane lipoprotein, PnrA, in Treponema pallidum and its homologs from other bacteria and Archaea; Region: PBP1_BmpA_PnrA_like; cd06354 552526002822 ligand binding site [chemical binding]; other site 552526002823 ABC-type uncharacterized transport systems, ATPase components [General function prediction only]; Region: COG3845 552526002824 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 552526002825 Walker A/P-loop; other site 552526002826 ATP binding site [chemical binding]; other site 552526002827 Q-loop/lid; other site 552526002828 ABC transporter signature motif; other site 552526002829 Walker B; other site 552526002830 D-loop; other site 552526002831 H-loop/switch region; other site 552526002832 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 552526002833 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 552526002834 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 552526002835 TM-ABC transporter signature motif; other site 552526002836 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 552526002837 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 552526002838 TM-ABC transporter signature motif; other site 552526002839 This CD includes PGM2 (phosphoglucomutase 2) and PGM2L1 (phosphoglucomutase 2-like 1). The mammalian PGM2 is thought to be a phosphopentomutase that catalyzes the conversion of the nucleoside breakdown products, ribose-1-phosphate and...; Region: PGM2; cd05799 552526002840 Phosphomannomutase [Carbohydrate transport and metabolism]; Region: {ManB}; COG1109 552526002841 active site 552526002842 substrate binding site [chemical binding]; other site 552526002843 metal binding site [ion binding]; metal-binding site 552526002844 Predicted membrane protein [Function unknown]; Region: COG4684 552526002845 Protein of unknown function (DUF3816); Region: DUF3816; pfam12822 552526002846 phosphopantothenoylcysteine decarboxylase; Validated; Region: PRK07313 552526002847 Flavoprotein; Region: Flavoprotein; pfam02441 552526002848 phosphopantothenate--cysteine ligase; Validated; Region: PRK06732 552526002849 formate--tetrahydrofolate ligase; Provisional; Region: PRK13505 552526002850 Formyltetrahydrofolate synthetase (FTHFS) catalyzes the ATP-dependent activation of formate ion via its addition to the N10 position of tetrahydrofolate. FTHFS is a highly expressed key enzyme in both the Wood-Ljungdahl pathway of autotrophic CO2...; Region: FTHFS; cd00477 552526002851 Potassium binding sites [ion binding]; other site 552526002852 Cesium cation binding sites [ion binding]; other site 552526002853 Peptidase S8 family domain in Streptococcal C5a peptidases; Region: Peptidases_S8_C5a_Peptidase; cd07475 552526002854 putative active site [active] 552526002855 catalytic triad [active] 552526002856 Peptidase S8 family domain in Streptococcal C5a peptidases; Region: Peptidases_S8_C5a_Peptidase; cd07475 552526002857 Fn3-like domain (DUF1034); Region: DUF1034; pfam06280 552526002858 C-terminal domain of CHU protein family; Region: CHU_C; cl17875 552526002859 Phosphatidylserine/phosphatidylglycerophosphate/car diolipin synthases and related enzymes [Lipid metabolism]; Region: Cls; COG1502 552526002860 Putative catalytic domain, repeat 1, of Streptococcus mutans uncharacterized protein SMU_988 and similar proteins; Region: PLDc_SMU_988_like_1; cd09154 552526002861 putative active site [active] 552526002862 catalytic site [active] 552526002863 Putative catalytic domain, repeat 2, of Streptococcus mutans uncharacterized protein SMU_988 and similar proteins; Region: PLDc_SMU_988_like_2; cd09160 552526002864 putative active site [active] 552526002865 catalytic site [active] 552526002866 aspartate-semialdehyde dehydrogenase; Provisional; Region: PRK14874 552526002867 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 552526002868 ATP cone domain; Region: ATP-cone; pfam03477 552526002869 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 552526002870 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 552526002871 DNA-binding site [nucleotide binding]; DNA binding site 552526002872 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 552526002873 pyridoxal 5'-phosphate binding site [chemical binding]; other site 552526002874 homodimer interface [polypeptide binding]; other site 552526002875 catalytic residue [active] 552526002876 pyridoxamine kinase; Validated; Region: PRK07105 552526002877 substrate binding site [chemical binding]; other site 552526002878 ATP binding site [chemical binding]; other site 552526002879 ECF-type riboflavin transporter, S component; Region: ECF-ribofla_trS; cl17272 552526002880 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 552526002881 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 552526002882 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 552526002883 ABC transporter; Region: ABC_tran_2; pfam12848 552526002884 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 552526002885 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 552526002886 Helix-turn-helix domain; Region: HTH_38; pfam13936 552526002887 Integrase core domain; Region: rve; pfam00665 552526002888 DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; pfam13808 552526002889 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 552526002890 DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; cl17880 552526002891 Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase [Lipid metabolism / General function prediction only]; Region: LCB5; COG1597 552526002892 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 552526002893 Predicted membrane protein, hemolysin III homolog [General function prediction only]; Region: COG1272 552526002894 channel protein, hemolysin III family; Region: hlyIII; TIGR01065 552526002895 Domain of unknown function (DUF1836); Region: DUF1836; pfam08876 552526002896 Methyltransferase domain; Region: Methyltransf_31; pfam13847 552526002897 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 552526002898 S-adenosylmethionine binding site [chemical binding]; other site 552526002899 Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1917 552526002900 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 552526002901 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 552526002902 active site 552526002903 phosphorylation site [posttranslational modification] 552526002904 intermolecular recognition site; other site 552526002905 dimerization interface [polypeptide binding]; other site 552526002906 LytTr DNA-binding domain; Region: LytTR; pfam04397 552526002907 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 552526002908 ABC-type multidrug transport system, ATPase component; Region: ABC_drug_resistance_like; cd03264 552526002909 Walker A/P-loop; other site 552526002910 ATP binding site [chemical binding]; other site 552526002911 Q-loop/lid; other site 552526002912 ABC transporter signature motif; other site 552526002913 Walker B; other site 552526002914 D-loop; other site 552526002915 H-loop/switch region; other site 552526002916 Bacteriocin class II with double-glycine leader peptide; Region: Bacteriocin_IIc; pfam10439 552526002917 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 552526002918 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 552526002919 catalytic residues [active] 552526002920 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4652 552526002921 Protein of unknown function (DUF1430); Region: DUF1430; pfam07242 552526002922 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 552526002923 putative bacteriocin export ABC transporter, lactococcin 972 group; Region: L_ocin_972_ABC; TIGR03608 552526002924 Walker A/P-loop; other site 552526002925 ATP binding site [chemical binding]; other site 552526002926 Q-loop/lid; other site 552526002927 ABC transporter signature motif; other site 552526002928 Walker B; other site 552526002929 D-loop; other site 552526002930 H-loop/switch region; other site 552526002931 GTPase YlqF; Reviewed; Region: rbgA; PRK09563 552526002932 Circularly permuted YlqF GTPase; Region: YlqF; cd01856 552526002933 GTP/Mg2+ binding site [chemical binding]; other site 552526002934 G4 box; other site 552526002935 G5 box; other site 552526002936 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 552526002937 G1 box; other site 552526002938 G1 box; other site 552526002939 GTP/Mg2+ binding site [chemical binding]; other site 552526002940 Switch I region; other site 552526002941 G2 box; other site 552526002942 G2 box; other site 552526002943 G3 box; other site 552526002944 G3 box; other site 552526002945 Switch II region; other site 552526002946 Switch II region; other site 552526002947 G4 box; other site 552526002948 G5 box; other site 552526002949 bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182 552526002950 RNA/DNA hybrid binding site [nucleotide binding]; other site 552526002951 active site 552526002952 DNA recombination-mediator protein A; Region: DNA_processg_A; pfam02481 552526002953 DNA protecting protein DprA; Region: dprA; TIGR00732 552526002954 DNA topoisomerase I; Validated; Region: PRK05582 552526002955 TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I. Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363 552526002956 active site 552526002957 interdomain interaction site; other site 552526002958 putative metal-binding site [ion binding]; other site 552526002959 nucleotide binding site [chemical binding]; other site 552526002960 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 552526002961 domain I; other site 552526002962 DNA binding groove [nucleotide binding] 552526002963 phosphate binding site [ion binding]; other site 552526002964 domain II; other site 552526002965 domain III; other site 552526002966 nucleotide binding site [chemical binding]; other site 552526002967 catalytic site [active] 552526002968 domain IV; other site 552526002969 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 552526002970 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 552526002971 Protein of unknown function (DUF3307); Region: DUF3307; pfam11750 552526002972 Transposase [DNA replication, recombination, and repair]; Region: COG5421 552526002973 Transposase [DNA replication, recombination, and repair]; Region: COG5421 552526002974 Citrate lyase synthetase [Energy production and conversion]; Region: CitC; COG3053 552526002975 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 552526002976 active site 552526002977 nucleotide binding site [chemical binding]; other site 552526002978 HIGH motif; other site 552526002979 KMSKS motif; other site 552526002980 Na+-transporting oxaloacetate decarboxylase beta subunit; Region: OAD_beta; cl00816 552526002981 Putative ammonia monooxygenase [General function prediction only]; Region: AbrB; COG3180 552526002982 membrane protein AbrB duplication; Region: Gneg_AbrB_dup; TIGR03082 552526002983 membrane protein AbrB duplication; Region: Gneg_AbrB_dup; TIGR03082 552526002984 ATP:dephospho-CoA triphosphoribosyl transferase; Region: CitG; cl00768 552526002985 Transcriptional regulators [Transcription]; Region: GntR; COG1802 552526002986 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 552526002987 DNA-binding site [nucleotide binding]; DNA binding site 552526002988 FCD domain; Region: FCD; pfam07729 552526002989 H+/citrate symporter [Energy production and conversion]; Region: CitM; COG2851 552526002990 Citrate transporter; Region: CitMHS; pfam03600 552526002991 acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated; Region: PRK06549 552526002992 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 552526002993 carboxyltransferase (CT) interaction site; other site 552526002994 biotinylation site [posttranslational modification]; other site 552526002995 Na+-transporting oxaloacetate decarboxylase beta subunit; Region: OAD_beta; pfam03977 552526002996 Oxaloacetate decarboxylase, gamma chain; Region: OAD_gamma; cl01458 552526002997 citrate lyase subunit gamma; Provisional; Region: PRK13253 552526002998 HpcH/HpaI aldolase/citrate lyase family; Region: HpcH_HpaI; cl17231 552526002999 Citrate lyase, alpha subunit [Energy production and conversion]; Region: CitF; COG3051 552526003000 Coenzyme A transferase; Region: CoA_trans; cl17247 552526003001 Acetyl-CoA hydrolase/transferase C-terminal domain; Region: AcetylCoA_hyd_C; pfam13336 552526003002 2'-(5''-triphosphoribosyl)-3'- dephospho-CoA:apo-citrate lyase; Reviewed; Region: citX; PRK01392 552526003003 PASTA domain. This domain is found at the C-termini of several Penicillin-binding proteins (PBPs) and bacterial serine/threonine kinases. It is a small globular fold consisting of 3 beta-sheets and an alpha-helix. The name PASTA is derived from PBP and...; Region: PASTA; cl02768 552526003004 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 552526003005 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 552526003006 Walker A/P-loop; other site 552526003007 ATP binding site [chemical binding]; other site 552526003008 Q-loop/lid; other site 552526003009 ABC transporter signature motif; other site 552526003010 Walker B; other site 552526003011 D-loop; other site 552526003012 H-loop/switch region; other site 552526003013 FtsX-like permease family; Region: FtsX; pfam02687 552526003014 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 552526003015 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 552526003016 active site 552526003017 phosphorylation site [posttranslational modification] 552526003018 intermolecular recognition site; other site 552526003019 dimerization interface [polypeptide binding]; other site 552526003020 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 552526003021 DNA binding site [nucleotide binding] 552526003022 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 552526003023 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 552526003024 ATP binding site [chemical binding]; other site 552526003025 Mg2+ binding site [ion binding]; other site 552526003026 G-X-G motif; other site 552526003027 site-specific tyrosine recombinase XerS; Reviewed; Region: xerS; PRK05084 552526003028 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 552526003029 active site 552526003030 DNA binding site [nucleotide binding] 552526003031 Int/Topo IB signature motif; other site 552526003032 GtrA-like protein; Region: GtrA; pfam04138 552526003033 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 552526003034 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 552526003035 non-specific DNA binding site [nucleotide binding]; other site 552526003036 salt bridge; other site 552526003037 sequence-specific DNA binding site [nucleotide binding]; other site 552526003038 Predicted transcriptional regulator [Transcription]; Region: COG2932 552526003039 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 552526003040 Catalytic site [active] 552526003041 GMP synthase; Reviewed; Region: guaA; PRK00074 552526003042 Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742 552526003043 AMP/PPi binding site [chemical binding]; other site 552526003044 candidate oxyanion hole; other site 552526003045 catalytic triad [active] 552526003046 potential glutamine specificity residues [chemical binding]; other site 552526003047 The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997 552526003048 ATP Binding subdomain [chemical binding]; other site 552526003049 Dimerization subdomain; other site 552526003050 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 552526003051 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 552526003052 DNA-binding site [nucleotide binding]; DNA binding site 552526003053 UTRA domain; Region: UTRA; pfam07702 552526003054 Putative helix-turn-helix protein, YlxM / p13 like; Region: UPF0122; pfam04297 552526003055 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 552526003056 signal recognition particle protein; Provisional; Region: PRK10867 552526003057 SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963 552526003058 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 552526003059 P loop; other site 552526003060 GTP binding site [chemical binding]; other site 552526003061 Signal peptide binding domain; Region: SRP_SPB; pfam02978 552526003062 FemAB family; Region: FemAB; pfam02388 552526003063 Predicted secreted protein [Function unknown]; Region: COG4086 552526003064 Protein of unknown function (DUF1002); Region: DUF1002; pfam06207 552526003065 streptococcal histidine triad protein; Region: strep_his_triad; TIGR01363 552526003066 Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297 552526003067 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 552526003068 intersubunit interface [polypeptide binding]; other site 552526003069 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_1; cd08352 552526003070 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 552526003071 putative metal binding site [ion binding]; other site 552526003072 Sortase A (SrtA) or subfamily-1 sortases are cysteine transpeptidases found in gram-positive bacteria that anchor surface proteins to peptidoglycans of the bacterial cell wall envelope. They do so by catalyzing a transpeptidation reaction in which the...; Region: Sortase_A_1; cd06165 552526003073 active site 552526003074 catalytic site [active] 552526003075 DNA gyrase subunit A; Validated; Region: PRK05560 552526003076 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 552526003077 CAP-like domain; other site 552526003078 active site 552526003079 primary dimer interface [polypeptide binding]; other site 552526003080 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 552526003081 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 552526003082 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 552526003083 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 552526003084 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 552526003085 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 552526003086 L-lactate dehydrogenase; Reviewed; Region: ldh; PRK00066 552526003087 L-2-hydroxyisocapronate dehydrogenases and some bacterial L-lactate dehydrogenases; Region: HicDH_like; cd05291 552526003088 tetramer (dimer of dimers) interface [polypeptide binding]; other site 552526003089 NAD binding site [chemical binding]; other site 552526003090 dimer interface [polypeptide binding]; other site 552526003091 substrate binding site [chemical binding]; other site 552526003092 coenzyme A disulfide reductase; Reviewed; Region: PRK09564 552526003093 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 552526003094 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 552526003095 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 552526003096 N-acetyl-D-glucosamine binding site [chemical binding]; other site 552526003097 catalytic residue [active] 552526003098 37-kD nucleoid-associated bacterial protein; Region: NA37; cl15473 552526003099 serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011 552526003100 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378 552526003101 dimer interface [polypeptide binding]; other site 552526003102 active site 552526003103 glycine-pyridoxal phosphate binding site [chemical binding]; other site 552526003104 folate binding site [chemical binding]; other site 552526003105 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 552526003106 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 552526003107 Coenzyme A binding pocket [chemical binding]; other site 552526003108 Putative translation factor (SUA5) [Translation, ribosomal structure and biogenesis]; Region: SUA5; COG0009 552526003109 N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328 552526003110 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 552526003111 S-adenosylmethionine binding site [chemical binding]; other site 552526003112 peptide chain release factor 1; Validated; Region: prfA; PRK00591 552526003113 This domain is found in peptide chain release factors; Region: PCRF; smart00937 552526003114 RF-1 domain; Region: RF-1; pfam00472 552526003115 thymidine kinase; Provisional; Region: PRK04296 552526003116 4-oxalocrotonate tautomerase; Provisional; Region: PRK02289 552526003117 active site 1 [active] 552526003118 dimer interface [polypeptide binding]; other site 552526003119 hexamer interface [polypeptide binding]; other site 552526003120 active site 2 [active] 552526003121 Membrane-associated lipoprotein involved in thiamine biosynthesis [Coenzyme metabolism]; Region: ApbE; COG1477 552526003122 ApbE family; Region: ApbE; pfam02424 552526003123 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 552526003124 active site 552526003125 guanosine 5'-monophosphate oxidoreductase; Provisional; Region: PRK05458 552526003126 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 552526003127 active site 552526003128 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 552526003129 dimer interface [polypeptide binding]; other site 552526003130 conserved gate region; other site 552526003131 putative PBP binding loops; other site 552526003132 ABC-ATPase subunit interface; other site 552526003133 Periplasmic glycine betaine/choline-binding (lipo)protein of an ABC-type transport system (osmoprotectant binding protein) [Cell envelope biogenesis, outer membrane]; Region: OpuBC; COG1732 552526003134 ABC-type proline/glycine betaine transport systems, periplasmic components [Amino acid transport and metabolism]; Region: ProX; cl17891 552526003135 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 552526003136 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 552526003137 Walker A/P-loop; other site 552526003138 ATP binding site [chemical binding]; other site 552526003139 Q-loop/lid; other site 552526003140 ABC transporter signature motif; other site 552526003141 Walker B; other site 552526003142 D-loop; other site 552526003143 H-loop/switch region; other site 552526003144 classical (c) SDR, subgroup 5; Region: SDR_c5; cd05346 552526003145 malonic semialdehyde reductase; Provisional; Region: PRK10538 552526003146 putative NAD(P) binding site [chemical binding]; other site 552526003147 homotetramer interface [polypeptide binding]; other site 552526003148 homodimer interface [polypeptide binding]; other site 552526003149 active site 552526003150 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 552526003151 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 552526003152 active site 552526003153 inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK04885 552526003154 ATP-NAD kinase; Region: NAD_kinase; pfam01513 552526003155 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 552526003156 synthetase active site [active] 552526003157 NTP binding site [chemical binding]; other site 552526003158 metal binding site [ion binding]; metal-binding site 552526003159 Uncharacterized subgroup 1 of the CYTH-like superfamily; Region: CYTH-like_Pase_1; cd07762 552526003160 putative active site [active] 552526003161 putative metal binding residues [ion binding]; other site 552526003162 signature motif; other site 552526003163 putative triphosphate binding site [ion binding]; other site 552526003164 ribose-phosphate pyrophosphokinase; Provisional; Region: PRK02458 552526003165 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 552526003166 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 552526003167 active site 552526003168 Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104 552526003169 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 552526003170 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 552526003171 catalytic residue [active] 552526003172 Putative amino acid metabolism; Region: DUF1831; pfam08866 552526003173 AT-rich DNA-binding protein [General function prediction only]; Region: COG2344 552526003174 Putative DNA-binding protein N-terminus; Region: Put_DNA-bind_N; pfam06971 552526003175 CoA binding domain; Region: CoA_binding; pfam02629 552526003176 Predicted glutamine amidotransferases [General function prediction only]; Region: COG2071 552526003177 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_2; cd01745 552526003178 catalytic triad [active] 552526003179 hypothetical protein; Reviewed; Region: PRK00024 552526003180 Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071 552526003181 MPN+ (JAMM) motif; other site 552526003182 Zinc-binding site [ion binding]; other site 552526003183 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 552526003184 Domain of unknown function DUF20; Region: UPF0118; pfam01594 552526003185 NnaC (CMP-NeuNAc synthetase) _like subfamily of SGNH_hydrolases, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its...; Region: NnaC_like; cd01841 552526003186 active site 552526003187 catalytic triad [active] 552526003188 oxyanion hole [active] 552526003189 ClC chloride channel EriC. This domain is found in the EriC chloride transporters that mediate the extreme acid resistance response in eubacteria and archaea. This response allows bacteria to survive in the acidic environments by decarboxylation-linked...; Region: EriC; cd01031 552526003190 Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038 552526003191 Cl- selectivity filter; other site 552526003192 Cl- binding residues [ion binding]; other site 552526003193 pore gating glutamate residue; other site 552526003194 dimer interface [polypeptide binding]; other site 552526003195 H+/Cl- coupling transport residue; other site 552526003196 Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687 552526003197 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 552526003198 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 552526003199 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 552526003200 dimer interface [polypeptide binding]; other site 552526003201 conserved gate region; other site 552526003202 putative PBP binding loops; other site 552526003203 ABC-ATPase subunit interface; other site 552526003204 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 552526003205 dimer interface [polypeptide binding]; other site 552526003206 conserved gate region; other site 552526003207 putative PBP binding loops; other site 552526003208 ABC-ATPase subunit interface; other site 552526003209 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 552526003210 ATP-binding cassette domain of the polyamine transporter; Region: ABC_PotA_N; cd03300 552526003211 Walker A/P-loop; other site 552526003212 ATP binding site [chemical binding]; other site 552526003213 Q-loop/lid; other site 552526003214 ABC transporter signature motif; other site 552526003215 Walker B; other site 552526003216 D-loop; other site 552526003217 H-loop/switch region; other site 552526003218 TOBE domain; Region: TOBE_2; pfam08402 552526003219 UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK13905 552526003220 FAD binding domain; Region: FAD_binding_4; pfam01565 552526003221 UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873 552526003222 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483 552526003223 catalytic center binding site [active] 552526003224 ATP binding site [chemical binding]; other site 552526003225 Dihydroneopterin aldolase (DHNA) and 7,8-dihydroneopterin triphosphate epimerase domain (DHNTPE); these enzymes have been designated folB and folX, respectively. Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and...; Region: DHNA_DHNTPE; cd00534 552526003226 homooctamer interface [polypeptide binding]; other site 552526003227 active site 552526003228 DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739 552526003229 dihydropteroate synthase; Region: DHPS; TIGR01496 552526003230 substrate binding pocket [chemical binding]; other site 552526003231 dimer interface [polypeptide binding]; other site 552526003232 inhibitor binding site; inhibition site 552526003233 GTP cyclohydrolase I (GTP-CH-I) catalyzes the conversion of GTP into dihydroneopterin triphosphate. The enzyme product is the precursor of tetrahydrofolate in eubacteria, fungi, and plants and of the folate analogs in methanogenic bacteria. In...; Region: GTP_cyclohydro1; cd00642 552526003234 homodecamer interface [polypeptide binding]; other site 552526003235 GTP cyclohydrolase I; Provisional; Region: PLN03044 552526003236 active site 552526003237 putative catalytic site residues [active] 552526003238 zinc binding site [ion binding]; other site 552526003239 GTP-CH-I/GFRP interaction surface; other site 552526003240 folylpolyglutamate synthase/dihydrofolate synthase; Region: folC; TIGR01499 552526003241 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 552526003242 homoserine kinase; Provisional; Region: PRK01212 552526003243 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 552526003244 homoserine dehydrogenase; Provisional; Region: PRK06349 552526003245 Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447 552526003246 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 552526003247 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 552526003248 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 552526003249 Putative catalytic NodB homology domain of PgaB, IcaB, and similar proteins which consist of a deformed (beta/alpha)8 barrel fold with 5- or 6-strands; Region: CE4_NodB_like_5s_6s; cd10918 552526003250 putative active site [active] 552526003251 putative metal binding site [ion binding]; other site 552526003252 DNA/RNA non-specific endonuclease; Region: Endonuclea_NS_2; cl17626 552526003253 DNA/RNA non-specific endonuclease; Region: Endonuclease_NS; smart00892 552526003254 Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413 552526003255 active site 552526003256 multimer interface [polypeptide binding]; other site 552526003257 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 552526003258 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 552526003259 Walker A motif; other site 552526003260 ATP binding site [chemical binding]; other site 552526003261 Walker B motif; other site 552526003262 arginine finger; other site 552526003263 UvrB/uvrC motif; Region: UVR; pfam02151 552526003264 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 552526003265 Walker A motif; other site 552526003266 ATP binding site [chemical binding]; other site 552526003267 Walker B motif; other site 552526003268 arginine finger; other site 552526003269 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 552526003270 Leucine rich repeats (6 copies); Region: LRR_5; pfam13306 552526003271 Leucine rich repeats (6 copies); Region: LRR_5; pfam13306 552526003272 Leucine rich repeats (6 copies); Region: LRR_5; pfam13306 552526003273 YihA (EngB) GTPase family; Region: YihA_EngB; cd01876 552526003274 G1 box; other site 552526003275 GTP/Mg2+ binding site [chemical binding]; other site 552526003276 Switch I region; other site 552526003277 G2 box; other site 552526003278 G3 box; other site 552526003279 Switch II region; other site 552526003280 G4 box; other site 552526003281 G5 box; other site 552526003282 ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342 552526003283 ClpX C4-type zinc finger; Region: zf-C4_ClpX; pfam06689 552526003284 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 552526003285 Walker A motif; other site 552526003286 ATP binding site [chemical binding]; other site 552526003287 Walker B motif; other site 552526003288 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 552526003289 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 552526003290 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cd00209 552526003291 folate binding site [chemical binding]; other site 552526003292 NADP+ binding site [chemical binding]; other site 552526003293 thymidylate synthase; Reviewed; Region: thyA; PRK01827 552526003294 Thymidylate synthase and pyrimidine hydroxymethylase: Thymidylate synthase (TS) and deoxycytidylate hydroxymethylase (dCMP-HMase) are homologs that catalyze analogous alkylation of C5 of pyrimidine nucleotides. Both enzymes are involved in the...; Region: TS_Pyrimidine_HMase; cd00351 552526003295 dimerization interface [polypeptide binding]; other site 552526003296 active site 552526003297 "initiating" condensing enzymes are a subclass of decarboxylating condensing enzymes, including beta-ketoacyl [ACP] synthase, type III and polyketide synthases, type III, which include chalcone synthase and related enzymes. They are...; Region: init_cond_enzymes; cd00827 552526003298 3-hydroxy-3-methylglutaryl CoA synthase, prokaryotic clade; Region: HMG-CoA-S_prok; TIGR01835 552526003299 dimer interface [polypeptide binding]; other site 552526003300 active site 552526003301 Class II hydroxymethylglutaryl-coenzyme A (HMG-CoA) reductase (HMGR); Region: HMG-CoA_reductase_classII; cd00644 552526003302 homodimer interface [polypeptide binding]; other site 552526003303 catalytic residues [active] 552526003304 NAD binding site [chemical binding]; other site 552526003305 substrate binding pocket [chemical binding]; other site 552526003306 flexible flap; other site 552526003307 isopentenyl pyrophosphate isomerase; Provisional; Region: PRK05437 552526003308 Isopentenyl-diphosphate:dimethylallyl diphosphate isomerase type 2 (IDI-2) FMN-binding domain. Two types of IDIs have been characterized at present. The long known IDI-1 is only dependent on divalent metals for activity, whereas IDI-2 requires a metal; Region: IDI-2_FMN; cd02811 552526003309 homotetramer interface [polypeptide binding]; other site 552526003310 FMN binding site [chemical binding]; other site 552526003311 homodimer contacts [polypeptide binding]; other site 552526003312 putative active site [active] 552526003313 putative substrate binding site [chemical binding]; other site 552526003314 Mevalonate kinase [Lipid metabolism]; Region: ERG12; COG1577 552526003315 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 552526003316 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 552526003317 diphosphomevalonate decarboxylase; Region: PLN02407 552526003318 diphosphomevalonate decarboxylase; Region: mevDPdecarb; TIGR01240 552526003319 mevalonate kinase; Region: mevalon_kin; TIGR00549 552526003320 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 552526003321 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 552526003322 ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254 552526003323 Walker A/P-loop; other site 552526003324 ATP binding site [chemical binding]; other site 552526003325 Q-loop/lid; other site 552526003326 ABC transporter signature motif; other site 552526003327 Walker B; other site 552526003328 D-loop; other site 552526003329 H-loop/switch region; other site 552526003330 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 552526003331 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 552526003332 Walker A/P-loop; other site 552526003333 ATP binding site [chemical binding]; other site 552526003334 Q-loop/lid; other site 552526003335 ABC transporter signature motif; other site 552526003336 Walker B; other site 552526003337 D-loop; other site 552526003338 H-loop/switch region; other site 552526003339 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 552526003340 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 552526003341 5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737 552526003342 Bacillus subtilis YhcR endonuclease and related proteins, N-terminal metallophosphatase domain; Region: MPP_YhcR_N; cd07412 552526003343 putative active site [active] 552526003344 putative metal binding site [ion binding]; other site 552526003345 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 552526003346 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 552526003347 active site 552526003348 catalytic residues [active] 552526003349 metal binding site [ion binding]; metal-binding site 552526003350 glutamate dehydrogenase; Provisional; Region: PRK09414 552526003351 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 552526003352 NAD(P) binding domain of glutamate dehydrogenase, subgroup 2; Region: NAD_bind_2_Glu_DH; cd05313 552526003353 NAD(P) binding site [chemical binding]; other site 552526003354 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 552526003355 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 552526003356 ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254 552526003357 Walker A/P-loop; other site 552526003358 ATP binding site [chemical binding]; other site 552526003359 Q-loop/lid; other site 552526003360 ABC transporter signature motif; other site 552526003361 Walker B; other site 552526003362 D-loop; other site 552526003363 H-loop/switch region; other site 552526003364 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 552526003365 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 552526003366 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 552526003367 Walker A/P-loop; other site 552526003368 ATP binding site [chemical binding]; other site 552526003369 Q-loop/lid; other site 552526003370 ABC transporter signature motif; other site 552526003371 Walker B; other site 552526003372 D-loop; other site 552526003373 H-loop/switch region; other site 552526003374 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 552526003375 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 552526003376 Walker A/P-loop; other site 552526003377 ATP binding site [chemical binding]; other site 552526003378 Q-loop/lid; other site 552526003379 ABC transporter signature motif; other site 552526003380 Walker B; other site 552526003381 D-loop; other site 552526003382 H-loop/switch region; other site 552526003383 ABC transporter; Region: ABC_tran_2; pfam12848 552526003384 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 552526003385 tRNA CCA-pyrophosphorylase; Provisional; Region: PRK13299 552526003386 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 552526003387 active site 552526003388 NTP binding site [chemical binding]; other site 552526003389 metal binding triad [ion binding]; metal-binding site 552526003390 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 552526003391 tRNA nucleotidyltransferase domain 2 putative; Region: tRNA_NucTran2_2; pfam13735 552526003392 EDD domain protein, DegV family; Region: DegV; TIGR00762 552526003393 Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645 552526003394 Protein of unknown function (DUF1149); Region: DUF1149; pfam06619 552526003395 Muramidase (flagellum-specific) [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FlgJ; COG1705 552526003396 transmembrane helices; other site 552526003397 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 552526003398 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221 552526003399 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 552526003400 non-specific DNA binding site [nucleotide binding]; other site 552526003401 salt bridge; other site 552526003402 sequence-specific DNA binding site [nucleotide binding]; other site 552526003403 Muramidase (flagellum-specific) [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FlgJ; COG1705 552526003404 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 552526003405 active site 552526003406 phosphorylation site [posttranslational modification] 552526003407 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569 552526003408 active site 552526003409 P-loop; other site 552526003410 phosphorylation site [posttranslational modification] 552526003411 Phosphotransferase system, fructose-specific IIC component [Carbohydrate transport and metabolism]; Region: FruA; COG1299 552526003412 Phosphotransferase system, EIIC; Region: PTS_EIIC; pfam02378 552526003413 Fructose-1-phosphate kinase and related fructose-6-phosphate kinase (PfkB) [Carbohydrate transport and metabolism]; Region: FruK; COG1105 552526003414 1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164 552526003415 putative substrate binding site [chemical binding]; other site 552526003416 putative ATP binding site [chemical binding]; other site 552526003417 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 552526003418 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 552526003419 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 552526003420 2-dehydropantoate 2-reductase; Reviewed; Region: PRK06522 552526003421 Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558 552526003422 Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546 552526003423 Predicted membrane protein, putative toxin regulator [General function prediction only]; Region: PfoR; COG3641 552526003424 Phosphotransferase system, EIIC; Region: PTS_EIIC_2; pfam13303 552526003425 Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492 552526003426 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 552526003427 tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026 552526003428 16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK00122 552526003429 RimM N-terminal domain; Region: RimM; pfam01782 552526003430 PRC-barrel domain; Region: PRC; pfam05239 552526003431 putative transposase OrfB; Reviewed; Region: PHA02517 552526003432 HTH-like domain; Region: HTH_21; pfam13276 552526003433 Integrase core domain; Region: rve; pfam00665 552526003434 Integrase core domain; Region: rve_2; pfam13333 552526003435 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 552526003436 Helix-turn-helix domain; Region: HTH_28; pfam13518 552526003437 Listeria-Bacteroides repeat domain (List_Bact_rpt); Region: Flg_new; pfam09479 552526003438 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 552526003439 Helix-turn-helix domain; Region: HTH_38; pfam13936 552526003440 Integrase core domain; Region: rve; pfam00665 552526003441 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 552526003442 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768 552526003443 catalytic residues [active] 552526003444 catalytic nucleophile [active] 552526003445 Presynaptic Site I dimer interface [polypeptide binding]; other site 552526003446 Synaptic Antiparallel dimer interface [polypeptide binding]; other site 552526003447 Synaptic Flat tetramer interface [polypeptide binding]; other site 552526003448 Synaptic Site I dimer interface [polypeptide binding]; other site 552526003449 DNA binding site [nucleotide binding] 552526003450 Predicted RNA-binding protein (contains KH domain) [General function prediction only]; Region: COG1837 552526003451 KH domain; Region: KH_4; pfam13083 552526003452 G-X-X-G motif; other site 552526003453 30S ribosomal protein S16; Reviewed; Region: rpsP; PRK00040 552526003454 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 552526003455 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 552526003456 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 552526003457 FtsX-like permease family; Region: FtsX; pfam02687 552526003458 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 552526003459 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 552526003460 Walker A/P-loop; other site 552526003461 ATP binding site [chemical binding]; other site 552526003462 Q-loop/lid; other site 552526003463 ABC transporter signature motif; other site 552526003464 Walker B; other site 552526003465 D-loop; other site 552526003466 H-loop/switch region; other site 552526003467 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 552526003468 HlyD family secretion protein; Region: HlyD_3; pfam13437 552526003469 carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294 552526003470 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 552526003471 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 552526003472 Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787 552526003473 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 552526003474 ATP-grasp domain; Region: ATP-grasp_4; cl17255 552526003475 Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424 552526003476 IMP binding site; other site 552526003477 dimer interface [polypeptide binding]; other site 552526003478 interdomain contacts; other site 552526003479 partial ornithine binding site; other site 552526003480 carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564 552526003481 Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; smart01097 552526003482 Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744 552526003483 catalytic site [active] 552526003484 subunit interface [polypeptide binding]; other site 552526003485 aspartate carbamoyltransferase catalytic subunit; Provisional; Region: pyrB; PRK00856 552526003486 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 552526003487 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 552526003488 uracil transporter; Provisional; Region: PRK10720 552526003489 Pyrimidine operon attenuation protein/uracil phosphoribosyltransferase [Nucleotide transport and metabolism]; Region: PyrR; COG2065 552526003490 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 552526003491 active site 552526003492 Uncharacterized conserved protein [Function unknown]; Region: COG0398 552526003493 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 552526003494 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 552526003495 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 552526003496 RNA binding surface [nucleotide binding]; other site 552526003497 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 552526003498 active site 552526003499 lipoprotein signal peptidase; Provisional; Region: PRK14797 552526003500 Transcriptional regulator [Transcription]; Region: LysR; COG0583 552526003501 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 552526003502 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 552526003503 dimerization interface [polypeptide binding]; other site 552526003504 50S ribosomal protein L27; Validated; Region: rpmA; PRK05435 552526003505 Protein of unknown function (DUF464); Region: DUF464; pfam04327 552526003506 50S ribosomal protein L21; Validated; Region: rplU; PRK05573 552526003507 Bacterial capsule synthesis protein PGA_cap; Region: PGA_cap; smart00854 552526003508 CapA and related proteins, metallophosphatase domain; Region: MPP_CapA; cd07381 552526003509 putative active site [active] 552526003510 putative metal binding site [ion binding]; other site 552526003511 Domain of Unknown Function with PDB structure (DUF3862); Region: DUF3862; pfam12978 552526003512 H+ Antiporter protein; Region: 2A0121; TIGR00900 552526003513 transcriptional activator, Rgg/GadR/MutR family, C-terminal domain; Region: RGG_Cterm; TIGR01716 552526003514 30S ribosomal protein S1; Reviewed; Region: rpsA; PRK06676 552526003515 S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687 552526003516 RNA binding site [nucleotide binding]; other site 552526003517 S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465 552526003518 RNA binding site [nucleotide binding]; other site 552526003519 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 552526003520 RNA binding site [nucleotide binding]; other site 552526003521 S1_RPS1_repeat_hs4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_hs4; cd05692 552526003522 RNA binding site [nucleotide binding]; other site 552526003523 Protein of unknown function (DUF2969); Region: DUF2969; pfam11184 552526003524 branched-chain amino acid aminotransferase; Provisional; Region: PRK13357 552526003525 BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557 552526003526 homodimer interface [polypeptide binding]; other site 552526003527 substrate-cofactor binding pocket; other site 552526003528 catalytic residue [active] 552526003529 DNA topoisomerase IV, A subunit, Gram-positive; Region: parC_Gpos; TIGR01061 552526003530 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 552526003531 CAP-like domain; other site 552526003532 active site 552526003533 primary dimer interface [polypeptide binding]; other site 552526003534 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 552526003535 DNA topoisomerase IV, B subunit, Gram-positive; Region: parE_Gpos; TIGR01058 552526003536 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 552526003537 Mg2+ binding site [ion binding]; other site 552526003538 G-X-G motif; other site 552526003539 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 552526003540 anchoring element; other site 552526003541 dimer interface [polypeptide binding]; other site 552526003542 ATP binding site [chemical binding]; other site 552526003543 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 552526003544 active site 552526003545 putative metal-binding site [ion binding]; other site 552526003546 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 552526003547 putative glycerol-3-phosphate acyltransferase PlsY; Provisional; Region: PRK00220 552526003548 dihydroorotase; Validated; Region: pyrC; PRK09357 552526003549 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 552526003550 Dihydroorotase (DHOase), subgroup IIa; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This subgroup also contains proteins that lack the active site, like unc-33, a C; Region: DHOase_IIa; cd01317 552526003551 active site 552526003552 Family 1 of Uracil-DNA glycosylase (UDG) enzymes; Region: UDG_F1; cd10027 552526003553 ligand binding site [chemical binding]; other site 552526003554 active site 552526003555 UGI interface [polypeptide binding]; other site 552526003556 catalytic site [active] 552526003557 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 552526003558 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 552526003559 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 552526003560 Coenzyme A binding pocket [chemical binding]; other site 552526003561 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 552526003562 dimer interface [polypeptide binding]; other site 552526003563 conserved gate region; other site 552526003564 putative PBP binding loops; other site 552526003565 ABC-ATPase subunit interface; other site 552526003566 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 552526003567 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 552526003568 substrate binding pocket [chemical binding]; other site 552526003569 membrane-bound complex binding site; other site 552526003570 hinge residues; other site 552526003571 amidase; Provisional; Region: PRK06529 552526003572 Amidase; Region: Amidase; cl11426 552526003573 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 552526003574 Coenzyme A binding pocket [chemical binding]; other site 552526003575 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 552526003576 active site 552526003577 Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725 552526003578 active site 552526003579 dimer interface [polypeptide binding]; other site 552526003580 Transcriptional regulator [Transcription]; Region: LysR; COG0583 552526003581 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 552526003582 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 552526003583 dimerization interface [polypeptide binding]; other site 552526003584 CRISPR/Cas system-associated protein Csm6; Region: Csm6_III-A; cl09873 552526003585 purine nucleoside phosphorylase; Provisional; Region: PRK08202 552526003586 phosphopentomutase; Provisional; Region: PRK05362 552526003587 Metalloenzyme superfamily; Region: Metalloenzyme; pfam01676 552526003588 RPI_A: Ribose 5-phosphate isomerase type A (RPI_A) subfamily; RPI catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate, the first step of the non-oxidative branch of the pentose phosphate pathway. This reaction leads to the...; Region: RPI_A; cd01398 552526003589 tetramer (dimer of dimers) interface [polypeptide binding]; other site 552526003590 active site 552526003591 dimer interface [polypeptide binding]; other site 552526003592 Domain of unknown function (DUF4176); Region: DUF4176; pfam13780 552526003593 type VII secretion effector, SACOL2603 family; Region: T7SS_SACOL2603; TIGR04197 552526003594 tRNA modification GTPase TrmE; Reviewed; Region: trmE; PRK05291 552526003595 GTP-binding protein TrmE N-terminus; Region: TrmE_N; pfam10396 552526003596 trmE is a tRNA modification GTPase; Region: trmE; cd04164 552526003597 G1 box; other site 552526003598 GTP/Mg2+ binding site [chemical binding]; other site 552526003599 Switch I region; other site 552526003600 G2 box; other site 552526003601 Switch II region; other site 552526003602 G3 box; other site 552526003603 G4 box; other site 552526003604 G5 box; other site 552526003605 Catalytic cysteine-containing C-terminus of GTPase, MnmE; Region: GTPase_Cys_C; pfam12631 552526003606 Nitroreductase-like family 1. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_1; cd02137 552526003607 dimer interface [polypeptide binding]; other site 552526003608 FMN binding site [chemical binding]; other site 552526003609 excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558 552526003610 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 552526003611 GIY-YIG motif/motif A; other site 552526003612 active site 552526003613 catalytic site [active] 552526003614 putative DNA binding site [nucleotide binding]; other site 552526003615 metal binding site [ion binding]; metal-binding site 552526003616 UvrB/uvrC motif; Region: UVR; pfam02151 552526003617 UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459 552526003618 ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840 552526003619 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 552526003620 Response regulator receiver domain; Region: Response_reg; pfam00072 552526003621 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 552526003622 active site 552526003623 phosphorylation site [posttranslational modification] 552526003624 intermolecular recognition site; other site 552526003625 dimerization interface [polypeptide binding]; other site 552526003626 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 552526003627 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 552526003628 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 552526003629 Phosphotransferase system, mannose/fructose/N-acetylgalactosamine-specific component IID [Carbohydrate transport and metabolism]; Region: ManZ; COG3716 552526003630 Phosphotransferase system, mannose/fructose/N-acetylgalactosamine-specific component IIC [Carbohydrate transport and metabolism]; Region: ManY; COG3715 552526003631 PTS system sorbose subfamily IIB component; Region: PTSIIB_sorb; pfam03830 552526003632 active site 552526003633 phosphorylation site [posttranslational modification] 552526003634 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cl00025 552526003635 active pocket/dimerization site; other site 552526003636 active site 552526003637 phosphorylation site [posttranslational modification] 552526003638 Predicted membrane protein [Function unknown]; Region: COG2855 552526003639 methionine sulfoxide reductase B; Provisional; Region: PRK00222 552526003640 SelR domain; Region: SelR; pfam01641 552526003641 GTP-binding protein LepA; Provisional; Region: PRK05433 552526003642 LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890 552526003643 G1 box; other site 552526003644 putative GEF interaction site [polypeptide binding]; other site 552526003645 GTP/Mg2+ binding site [chemical binding]; other site 552526003646 Switch I region; other site 552526003647 G2 box; other site 552526003648 G3 box; other site 552526003649 Switch II region; other site 552526003650 G4 box; other site 552526003651 G5 box; other site 552526003652 lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699 552526003653 lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane. LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709 552526003654 GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421 552526003655 Enterocin A Immunity; Region: EntA_Immun; pfam08951 552526003656 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 552526003657 Q-loop/lid; other site 552526003658 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 552526003659 ABC transporter signature motif; other site 552526003660 Walker B; other site 552526003661 D-loop; other site 552526003662 H-loop/switch region; other site 552526003663 COMC family; Region: ComC; pfam03047 552526003664 Transposase IS200 like; Region: Y1_Tnp; pfam01797 552526003665 Transposase IS200 like; Region: Y1_Tnp; pfam01797 552526003666 Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387 552526003667 core dimer interface [polypeptide binding]; other site 552526003668 L10 interface [polypeptide binding]; other site 552526003669 L11 interface [polypeptide binding]; other site 552526003670 putative EF-Tu interaction site [polypeptide binding]; other site 552526003671 putative EF-G interaction site [polypeptide binding]; other site 552526003672 Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797 552526003673 23S rRNA interface [nucleotide binding]; other site 552526003674 Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site 552526003675 Protein of unknown function (DUF1461); Region: DUF1461; cl01862 552526003676 HAD-superfamily subfamily IIA hydrolase, TIGR01457; Region: HAD-SF-IIA-hyp2 552526003677 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 552526003678 active site 552526003679 motif I; other site 552526003680 motif II; other site 552526003681 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 552526003682 Acyl-ACP thioesterase; Region: Acyl-ACP_TE; pfam01643 552526003683 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 552526003684 active site 552526003685 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 552526003686 active site 1 [active] 552526003687 coproporphyrinogen III oxidase; Provisional; Region: PRK08599 552526003688 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 552526003689 FeS/SAM binding site; other site 552526003690 HemN C-terminal domain; Region: HemN_C; pfam06969 552526003691 Acetyltransferase (GNAT) domain; Region: Acetyltransf_8; pfam13523 552526003692 phosphoglucosamine mutase; Provisional; Region: glmM; PRK14316 552526003693 GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802 552526003694 active site 552526003695 substrate binding site [chemical binding]; other site 552526003696 metal binding site [ion binding]; metal-binding site 552526003697 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4856 552526003698 YbbR-like protein; Region: YbbR; pfam07949 552526003699 YbbR-like protein; Region: YbbR; pfam07949 552526003700 Uncharacterized conserved protein [Function unknown]; Region: COG1624 552526003701 DisA bacterial checkpoint controller nucleotide-binding; Region: DisA_N; pfam02457 552526003702 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyric Acid Synthase (CobQ); Region: GATase1_CobQ; cd01750 552526003703 catalytic triad [active] 552526003704 Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095 552526003705 lipoyltransferase and lipoate-protein ligase; Region: lipoyltrans; TIGR00545 552526003706 Bacterial lipoate protein ligase C-terminus; Region: Lip_prot_lig_C; pfam10437 552526003707 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 552526003708 E3 interaction surface; other site 552526003709 lipoyl attachment site [posttranslational modification]; other site 552526003710 dihydrolipoamide dehydrogenase; Region: lipoamide_DH; TIGR01350 552526003711 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 552526003712 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 552526003713 branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856 552526003714 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 552526003715 E3 interaction surface; other site 552526003716 lipoyl attachment site [posttranslational modification]; other site 552526003717 e3 binding domain; Region: E3_binding; pfam02817 552526003718 e3 binding domain; Region: E3_binding; pfam02817 552526003719 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 552526003720 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 552526003721 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 552526003722 alpha subunit interface [polypeptide binding]; other site 552526003723 TPP binding site [chemical binding]; other site 552526003724 heterodimer interface [polypeptide binding]; other site 552526003725 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 552526003726 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, alpha subunit [Energy production and conversion]; Region: AcoA; COG1071 552526003727 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 552526003728 tetramer interface [polypeptide binding]; other site 552526003729 TPP-binding site [chemical binding]; other site 552526003730 heterodimer interface [polypeptide binding]; other site 552526003731 phosphorylation loop region [posttranslational modification] 552526003732 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 552526003733 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 552526003734 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 552526003735 ABC transporter; Region: ABC_tran_2; pfam12848 552526003736 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 552526003737 Predicted esterase [General function prediction only]; Region: COG0627 552526003738 S-formylglutathione hydrolase; Region: PLN02442 552526003739 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819 552526003740 mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595 552526003741 Metallo-beta-lactamase superfamily; Region: Lactamase_B; pfam00753 552526003742 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 552526003743 ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: PhnK; COG1101 552526003744 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 552526003745 Walker A/P-loop; other site 552526003746 ATP binding site [chemical binding]; other site 552526003747 Q-loop/lid; other site 552526003748 ABC transporter signature motif; other site 552526003749 Walker B; other site 552526003750 D-loop; other site 552526003751 H-loop/switch region; other site 552526003752 Transmembrane subunit (TM) of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which are involved in the uptake of branched-chain amino acids (AAs), as well as TMs of transporters involved in the uptake of...; Region: TM_PBP1_branched-chain-AA_like; cd06574 552526003753 TM-ABC transporter signature motif; other site 552526003754 Transmembrane subunit (TM) of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which are involved in the uptake of branched-chain amino acids (AAs), as well as TMs of transporters involved in the uptake of...; Region: TM_PBP1_branched-chain-AA_like; cl00454 552526003755 Type I periplasmic ligand-binding domain of uncharacterized ABC-type transport systems that are predicted to be involved in the uptake of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_uncharacterized_transporter; cd06325 552526003756 zinc binding site [ion binding]; other site 552526003757 putative ligand binding site [chemical binding]; other site 552526003758 Predicted RNA-binding protein homologous to eukaryotic snRNP [Transcription]; Region: COG1293 552526003759 Domain of unknown function (DUF814); Region: DUF814; pfam05670 552526003760 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 552526003761 TPR motif; other site 552526003762 binding surface 552526003763 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 552526003764 binding surface 552526003765 TPR motif; other site 552526003766 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 552526003767 Domain of unknown function DUF20; Region: UPF0118; pfam01594 552526003768 MutT homolog-1 (MTH1) is a member of the Nudix hydrolase superfamily. MTH1, the mammalian counterpart of MutT, hydrolyzes oxidized purine nucleoside triphosphates, such as 8-oxo-dGTP and 2-hydroxy-ATP, to monophosphates, thereby preventing the...; Region: MTH1; cd03427 552526003769 putative active site [active] 552526003770 nucleotide binding site [chemical binding]; other site 552526003771 nudix motif; other site 552526003772 putative metal binding site [ion binding]; other site 552526003773 dTDP-D-glucose 4,6-dehydratase [Cell envelope biogenesis, outer membrane]; Region: RfbB; COG1088 552526003774 dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246 552526003775 NAD binding site [chemical binding]; other site 552526003776 substrate binding site [chemical binding]; other site 552526003777 homodimer interface [polypeptide binding]; other site 552526003778 active site 552526003779 dTDP-4-dehydrorhamnose 3,5-epimerase and related enzymes [Cell envelope biogenesis, outer membrane]; Region: RfbC; COG1898 552526003780 G1P_TT_short is the short form of glucose-1-phosphate thymidylyltransferase; Region: G1P_TT_short; cd02538 552526003781 glucose-1-phosphate thymidylyltransferase, short form; Region: rmlA; TIGR01207 552526003782 substrate binding site; other site 552526003783 tetramer interface; other site 552526003784 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 552526003785 Uncharacterized conserved protein [Function unknown]; Region: COG0327 552526003786 NIF3 (NGG1p interacting factor 3); Region: NIF3; pfam01784 552526003787 Predicted SAM-dependent methyltransferase [General function prediction only]; Region: COG2384 552526003788 Family of unknown function (DUF633); Region: DUF633; pfam04816 552526003789 Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177 552526003790 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 552526003791 minor groove reading motif; other site 552526003792 helix-hairpin-helix signature motif; other site 552526003793 substrate binding pocket [chemical binding]; other site 552526003794 active site 552526003795 Iron-sulfur binding domain of endonuclease III; Region: EndIII_4Fe-2S; cl15304 552526003796 Putative primosome component and related proteins [DNA replication, recombination, and repair]; Region: DnaD; COG3935 552526003797 Replication initiation and membrane attachment; Region: DnaB_2; pfam07261 552526003798 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 552526003799 active site 552526003800 conserved hypothetical protein; Region: TIGR02328 552526003801 Pyrimidine dimer DNA glycosylase; Region: Pyr_excise; pfam03013 552526003802 single-stranded-DNA-specific exonuclease RecJ; Region: recJ; TIGR00644 552526003803 DHH family; Region: DHH; pfam01368 552526003804 DHHA1 domain; Region: DHHA1; pfam02272 552526003805 Single-strand DNA-specific exonuclease, C terminal domain; Region: ssDNA-exonuc_C; cl11538 552526003806 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 552526003807 classical (c) SDRs; Region: SDR_c; cd05233 552526003808 NAD(P) binding site [chemical binding]; other site 552526003809 active site 552526003810 ribonuclease Z; Region: RNase_Z; TIGR02651 552526003811 Galactose-1-phosphate uridyl transferase, N-terminal domain; Region: GalP_UDP_transf; pfam01087 552526003812 GTP-binding protein HflX; Region: GTP_HflX; TIGR03156 552526003813 GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167 552526003814 HflX GTPase family; Region: HflX; cd01878 552526003815 G1 box; other site 552526003816 GTP/Mg2+ binding site [chemical binding]; other site 552526003817 Switch I region; other site 552526003818 G2 box; other site 552526003819 G3 box; other site 552526003820 Switch II region; other site 552526003821 G4 box; other site 552526003822 G5 box; other site 552526003823 tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091 552526003824 tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324 552526003825 Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190 552526003826 active site 552526003827 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 552526003828 glycogen/starch/alpha-glucan phosphorylases; Region: P_ylase; TIGR02093 552526003829 4-alpha-glucanotransferase; Provisional; Region: PRK14508 552526003830 Transcriptional regulators [Transcription]; Region: PurR; COG1609 552526003831 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 552526003832 DNA binding site [nucleotide binding] 552526003833 domain linker motif; other site 552526003834 Ligand-binding domain of uncharacterized transcription regulator ycjW which is a member of the LacI-GalR family repressors; Region: PBP1_ycjW_transcription_regulator_like; cd06294 552526003835 putative dimerization interface [polypeptide binding]; other site 552526003836 putative ligand binding site [chemical binding]; other site 552526003837 Maltose-binding periplasmic proteins/domains [Carbohydrate transport and metabolism]; Region: MalE; COG2182 552526003838 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 552526003839 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 552526003840 dimer interface [polypeptide binding]; other site 552526003841 conserved gate region; other site 552526003842 ABC-ATPase subunit interface; other site 552526003843 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 552526003844 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 552526003845 dimer interface [polypeptide binding]; other site 552526003846 conserved gate region; other site 552526003847 putative PBP binding loops; other site 552526003848 ABC-ATPase subunit interface; other site 552526003849 Predicted integral membrane protein [Function unknown]; Region: COG5521 552526003850 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 552526003851 dimer interface [polypeptide binding]; other site 552526003852 conserved gate region; other site 552526003853 putative PBP binding loops; other site 552526003854 ABC-ATPase subunit interface; other site 552526003855 Alpha amylase catalytic domain found in maltogenic amylases, cyclodextrin glycosyltransferase, and related proteins; Region: AmyAc_AmyMalt_CGTase_like; cd11320 552526003856 Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366 552526003857 Ca binding site [ion binding]; other site 552526003858 active site 552526003859 catalytic site [active] 552526003860 Aamy_C domain; Region: Aamy_C; smart00632 552526003861 IPT domain (domain D) of cyclodextrin glycosyltransferase (CGTase) and similar enzymes. These enzymes are involved in the enzymatic hydrolysis of alpha-1,4 linkages of starch polymers and belong to the glycosyl hydrolase family 13. Most consist of three...; Region: IPT_CGTD; cd00604 552526003862 The family 20 carbohydrate-binding module (CBM20), also known as the starch-binding domain, is found in a large number of starch degrading enzymes including alpha-amylase, beta-amylase, glucoamylase, and CGTase (cyclodextrin glucanotransferase). CBM20 is...; Region: CBM20; cl15347 552526003863 starch-binding site 2 [chemical binding]; other site 552526003864 starch-binding site 1 [chemical binding]; other site 552526003865 maltodextrin glucosidase; Provisional; Region: PRK10785 552526003866 N-terminal Early set domain associated with the catalytic domain of cyclomaltodextrinase and pullulan-degrading enzymes; Region: E_set_CDase_PDE_N; cd02857 552526003867 homodimer interface [polypeptide binding]; other site 552526003868 Alpha amylase catalytic domain found in cyclomaltodextrinases and related proteins; Region: AmyAc_CMD; cd11338 552526003869 active site 552526003870 homodimer interface [polypeptide binding]; other site 552526003871 catalytic site [active] 552526003872 Maltose-binding periplasmic proteins/domains [Carbohydrate transport and metabolism]; Region: MalE; COG2182 552526003873 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 552526003874 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 552526003875 Protein of unknown function (DUF2424); Region: DUF2424; pfam10340 552526003876 Protein involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein) [Cell envelope biogenesis, outer membrane]; Region: DltD; COG3966 552526003877 DltD N-terminal region; Region: DltD_N; pfam04915 552526003878 DltD central region; Region: DltD_M; pfam04918 552526003879 DltD C-terminal region; Region: DltD_C; pfam04914 552526003880 D-alanine--poly(phosphoribitol) ligase subunit 2; Validated; Region: PRK05087 552526003881 D-alanyl-lipoteichoic acid biosynthesis protein DltB; Region: LTA_dltB; TIGR04091 552526003882 D-alanine--poly(phosphoribitol) ligase subunit 1; Provisional; Region: PRK04813 552526003883 D-alanine:D-alanyl carrier protein ligase (DltA); Region: DltA; cd05945 552526003884 acyl-activating enzyme (AAE) consensus motif; other site 552526003885 AMP binding site [chemical binding]; other site 552526003886 D-Ala-teichoic acid biosynthesis protein; Region: DUF3687; pfam12459 552526003887 excinuclease ABC subunit B; Provisional; Region: PRK05298 552526003888 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 552526003889 ATP binding site [chemical binding]; other site 552526003890 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 552526003891 nucleotide binding region [chemical binding]; other site 552526003892 ATP-binding site [chemical binding]; other site 552526003893 Ultra-violet resistance protein B; Region: UvrB; pfam12344 552526003894 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 552526003895 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 552526003896 substrate binding pocket [chemical binding]; other site 552526003897 membrane-bound complex binding site; other site 552526003898 hinge residues; other site 552526003899 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 552526003900 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 552526003901 substrate binding pocket [chemical binding]; other site 552526003902 membrane-bound complex binding site; other site 552526003903 hinge residues; other site 552526003904 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 552526003905 dimer interface [polypeptide binding]; other site 552526003906 conserved gate region; other site 552526003907 putative PBP binding loops; other site 552526003908 ABC-ATPase subunit interface; other site 552526003909 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 552526003910 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 552526003911 Walker A/P-loop; other site 552526003912 ATP binding site [chemical binding]; other site 552526003913 Q-loop/lid; other site 552526003914 ABC transporter signature motif; other site 552526003915 Walker B; other site 552526003916 D-loop; other site 552526003917 H-loop/switch region; other site 552526003918 Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455 552526003919 cellobiose phosphotransferase system IIC component; Reviewed; Region: celD; PRK09592 552526003920 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cd07812 552526003921 hydrophobic ligand binding site; other site 552526003922 PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_lac; cd00215 552526003923 active site 552526003924 methionine cluster; other site 552526003925 phosphorylation site [posttranslational modification] 552526003926 metal binding site [ion binding]; metal-binding site 552526003927 PTS_IIB_chitobiose_lichenan: subunit IIB of enzyme II (EII) of the N,N-diacetylchitobiose-specific and lichenan-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In these systems, EII is either a lichenan- or an N; Region: PTS_IIB_chitobiose_lichenan; cd05564 552526003928 active site 552526003929 P-loop; other site 552526003930 phosphorylation site [posttranslational modification] 552526003931 Transcriptional antiterminator [Transcription]; Region: BglG; COG3711 552526003932 HTH domain; Region: HTH_11; pfam08279 552526003933 Mga helix-turn-helix domain; Region: Mga; pfam05043 552526003934 PRD domain; Region: PRD; pfam00874 552526003935 PRD domain; Region: PRD; pfam00874 552526003936 PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568 552526003937 active site 552526003938 P-loop; other site 552526003939 phosphorylation site [posttranslational modification] 552526003940 Phosphotransferase system mannitol/fructose-specific IIA domain (Ntr-type) [Carbohydrate transport and metabolism / Signal transduction mechanisms]; Region: PtsN; COG1762 552526003941 active site 552526003942 phosphorylation site [posttranslational modification] 552526003943 Uncharacterized conserved protein [Function unknown]; Region: COG3589 552526003944 Bacterial protein of unknown function (DUF871); Region: DUF871; pfam05913 552526003945 Nicotinamide mononucleotide transporter; Region: NMN_transporter; pfam04973 552526003946 GTPase CgtA; Reviewed; Region: obgE; PRK12297 552526003947 GTP1/OBG; Region: GTP1_OBG; pfam01018 552526003948 Obg GTPase; Region: Obg; cd01898 552526003949 G1 box; other site 552526003950 GTP/Mg2+ binding site [chemical binding]; other site 552526003951 Switch I region; other site 552526003952 G2 box; other site 552526003953 G3 box; other site 552526003954 Switch II region; other site 552526003955 G4 box; other site 552526003956 G5 box; other site 552526003957 Domain of unknown function (DUF1967); Region: DUF1967; pfam09269 552526003958 Thermophilic metalloprotease (M29); Region: Peptidase_M29; pfam02073 552526003959 Leucyl aminopeptidase (aminopeptidase T) [Amino acid transport and metabolism]; Region: AmpS; COG2309 552526003960 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 552526003961 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 552526003962 RNA binding surface [nucleotide binding]; other site 552526003963 Pseudouridine synthase, Escherichia coli RsuA like; Region: PseudoU_synth_RsuA; cd02553 552526003964 active site 552526003965 uracil binding [chemical binding]; other site 552526003966 Predicted thioesterase [General function prediction only]; Region: COG5496 552526003967 benzoate transport; Region: 2A0115; TIGR00895 552526003968 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 552526003969 putative substrate translocation pore; other site 552526003970 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4868 552526003971 hypothetical protein; Provisional; Region: PRK13663 552526003972 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 552526003973 Thioesterase-like superfamily; Region: 4HBT_3; pfam13622 552526003974 CoenzymeA binding site [chemical binding]; other site 552526003975 subunit interaction site [polypeptide binding]; other site 552526003976 PHB binding site; other site 552526003977 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 552526003978 Haloacid dehalogenase-like hydrolase; Region: HAD_2; pfam13419 552526003979 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 552526003980 motif II; other site 552526003981 Glycosaminoglycan (GAG) polysaccharide lyase family. This family consists of a group of secreted bacterial lyase enzymes capable of acting on glycosaminoglycans, such as hyaluronan and chondroitin, in the extracellular matrix of host tissues; Region: GAG_Lyase; cd01083 552526003982 substrate binding site [chemical binding]; other site 552526003983 catalytic residues [active] 552526003984 2-keto-3-deoxy-6-phosphogluconate aldolase [Carbohydrate transport and metabolism]; Region: Eda; COG0800 552526003985 KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452 552526003986 active site 552526003987 intersubunit interface [polypeptide binding]; other site 552526003988 catalytic residue [active] 552526003989 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 552526003990 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166 552526003991 substrate binding site [chemical binding]; other site 552526003992 ATP binding site [chemical binding]; other site 552526003993 hypothetical protein; Provisional; Region: PRK09273 552526003994 Ribose 5-phosphate isomerase RpiB [Carbohydrate transport and metabolism]; Region: RpiB; COG0698 552526003995 Ribose-5-phosphate isomerase; Region: DUF3666; pfam12408 552526003996 gluconate 5-dehydrogenase; Provisional; Region: PRK07097 552526003997 gluconate 5-dehydrogenase (Ga5DH)-like, classical (c) SDRs; Region: Ga5DH-like_SDR_c; cd05347 552526003998 NADP binding site [chemical binding]; other site 552526003999 homodimer interface [polypeptide binding]; other site 552526004000 active site 552526004001 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006 552526004002 active pocket/dimerization site; other site 552526004003 active site 552526004004 phosphorylation site [posttranslational modification] 552526004005 Glycosyl Hydrolase Family 88; Region: Glyco_hydro_88; pfam07470 552526004006 PTS_IIB, PTS system, Mannose/sorbose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_man; cd00001 552526004007 active site 552526004008 phosphorylation site [posttranslational modification] 552526004009 Phosphotransferase system, mannose/fructose/N-acetylgalactosamine-specific component IIC [Carbohydrate transport and metabolism]; Region: ManY; COG3715 552526004010 Phosphotransferase system, mannose/fructose/N-acetylgalactosamine-specific component IID [Carbohydrate transport and metabolism]; Region: ManZ; COG3716 552526004011 Transcriptional regulators [Transcription]; Region: PurR; COG1609 552526004012 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 552526004013 DNA binding site [nucleotide binding] 552526004014 domain linker motif; other site 552526004015 Ligand-binding domain of DNA transcription repressor RegR and other putative regulators such as KdgR and EndR; Region: PBP1_RegR_EndR_KdgR_like; cd06283 552526004016 putative dimerization interface [polypeptide binding]; other site 552526004017 putative ligand binding site [chemical binding]; other site 552526004018 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 552526004019 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; smart00831 552526004020 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 552526004021 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 552526004022 haloacid dehalogenase-like hydrolase; Region: HAD; pfam12710 552526004023 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 552526004024 Domain of unknown function (DUF1934); Region: DUF1934; pfam09148 552526004025 HD superfamily phosphohydrolases [General function prediction only]; Region: COG1078 552526004026 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 552526004027 Zn2+ binding site [ion binding]; other site 552526004028 Mg2+ binding site [ion binding]; other site 552526004029 sugar phosphate phosphatase; Provisional; Region: PRK10513 552526004030 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 552526004031 active site 552526004032 motif I; other site 552526004033 motif II; other site 552526004034 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 552526004035 FemAB family; Region: FemAB; pfam02388 552526004036 Acetyltransferase (GNAT) domain; Region: Acetyltransf_6; pfam13480 552526004037 FemAB family; Region: FemAB; pfam02388 552526004038 Acetyltransferase (GNAT) domain; Region: Acetyltransf_6; pfam13480 552526004039 triosephosphate isomerase; Provisional; Region: PRK14567 552526004040 Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311 552526004041 substrate binding site [chemical binding]; other site 552526004042 dimer interface [polypeptide binding]; other site 552526004043 catalytic triad [active] 552526004044 elongation factor Tu; Reviewed; Region: PRK00049 552526004045 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 552526004046 G1 box; other site 552526004047 GEF interaction site [polypeptide binding]; other site 552526004048 GTP/Mg2+ binding site [chemical binding]; other site 552526004049 Switch I region; other site 552526004050 G2 box; other site 552526004051 G3 box; other site 552526004052 Switch II region; other site 552526004053 G4 box; other site 552526004054 G5 box; other site 552526004055 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 552526004056 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 552526004057 Antibiotic Binding Site [chemical binding]; other site 552526004058 Viral enhancin protein; Region: Enhancin; pfam03272 552526004059 Viral enhancin protein; Region: Enhancin; pfam03272 552526004060 Sigma factor regulator C-terminal; Region: Sigma_reg_C; pfam13791 552526004061 RNA polymerase sigma factor, SigM family; Region: SigM_subfam; TIGR02950 552526004062 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 552526004063 DNA binding residues [nucleotide binding] 552526004064 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 552526004065 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 552526004066 non-specific DNA binding site [nucleotide binding]; other site 552526004067 salt bridge; other site 552526004068 sequence-specific DNA binding site [nucleotide binding]; other site 552526004069 CRISPR/Cas system-associated protein Csn2; Region: Csn2; cd09758 552526004070 CRISPR type II-A/NMEMI-associated protein Csn2; Region: cas_Csn2; TIGR01866 552526004071 tetramer interface [polypeptide binding]; other site 552526004072 putative DNA binding site [nucleotide binding]; other site 552526004073 Ca binding site [ion binding]; other site 552526004074 Ca binding site [ion binding]; other site 552526004075 CRISPR/Cas system-associated protein Cas2; Region: Cas2_I_II_III; cd09638 552526004076 CRISPR/Cas system-associated protein Cas1; Region: Cas1_II; cd09720 552526004077 Predicted CRISPR-associated nuclease, contains McrA/HNH-nuclease and RuvC-like nuclease domain [Defense mechanisms]; Region: COG3513 552526004078 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cl00083 552526004079 CRISPR/Cas system-associated protein Cas9; Region: Csn1; cd09643 552526004080 Protein of unknown function (DUF4237); Region: DUF4237; pfam14021 552526004081 Domain of unknown function (DUF1910); Region: DUF1910; pfam08928 552526004082 Domain of unknown function (DUF1911); Region: DUF1911; pfam08929 552526004083 bifunctional N-succinyldiaminopimelate-aminotransferase/acetylornithine transaminase protein; Reviewed; Region: argD; PRK05093 552526004084 Protein of unknown function (DUF4237); Region: DUF4237; pfam14021 552526004085 LXG domain of WXG superfamily; Region: LXG; pfam04740 552526004086 putative transposase OrfB; Reviewed; Region: PHA02517 552526004087 HTH-like domain; Region: HTH_21; pfam13276 552526004088 Integrase core domain; Region: rve; pfam00665 552526004089 Integrase core domain; Region: rve_2; pfam13333 552526004090 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 552526004091 Helix-turn-helix domain; Region: HTH_28; pfam13518 552526004092 Predicted hydrolase (HAD superfamily) [General function prediction only]; Region: COG1011 552526004093 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 552526004094 motif II; other site 552526004095 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 552526004096 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 552526004097 putative substrate translocation pore; other site 552526004098 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 552526004099 lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484 552526004100 LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322 552526004101 dimer interface [polypeptide binding]; other site 552526004102 putative anticodon binding site; other site 552526004103 Lys_tRNA synthetase (LysRS) class II core domain. Class II LysRS is a dimer which attaches a lysine to the 3' OH group of ribose of the appropriate tRNA. Its assignment to class II aaRS is based upon its structure and the presence of three...; Region: LysRS_core; cd00775 552526004104 motif 1; other site 552526004105 active site 552526004106 motif 2; other site 552526004107 motif 3; other site 552526004108 Uncharacterized protein conserved in bacteria (DUF2128); Region: DUF2128; pfam09901 552526004109 Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826 552526004110 Peptidase family U32; Region: Peptidase_U32; pfam01136 552526004111 Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826 552526004112 Peptidase family U32; Region: Peptidase_U32; pfam01136 552526004113 Protein of unknown function (DUF3270); Region: DUF3270; pfam11674 552526004114 Uncharacterized protein containing a divergent version of the methyl-accepting chemotaxis-like domain [General function prediction only]; Region: COG4768 552526004115 Prolipoprotein diacylglyceryl transferase; Region: LGT; pfam01790 552526004116 HPr Serine kinase N terminus; Region: Hpr_kinase_N; pfam02603 552526004117 HPr kinase/phosphorylase; Provisional; Region: PRK05428 552526004118 HprK/P, the bifunctional histidine-containing protein kinase/phosphatase, controls the phosphorylation state of the phosphocarrier protein HPr and regulates the utilization of carbon sources by gram-positive bacteria. It catalyzes both the ATP-dependent...; Region: HprK_C; cd01918 552526004119 Hpr binding site; other site 552526004120 active site 552526004121 homohexamer subunit interaction site [polypeptide binding]; other site 552526004122 Putative stress-responsive transcriptional regulator [Transcription / Signal transduction mechanisms]; Region: PspC; COG1983 552526004123 hypothetical protein; Provisional; Region: PRK04351 552526004124 Zn-dependent metalloprotease, SprT family [General function prediction only]; Region: SprT; COG3091 552526004125 Transcriptional accessory protein [Transcription]; Region: Tex; COG2183 552526004126 Tex-like protein N-terminal domain; Region: Tex_N; pfam09371 552526004127 Likely ribonuclease with RNase H fold; Region: YqgFc; smart00732 552526004128 S1_Tex: The C-terminal S1 domain of a transcription accessory factor called Tex, which has been characterized in Bordetella pertussis and Pseudomonas aeruginosa. The tex gene is essential in Bortella pertusis and is named for its role in toxin expression; Region: S1_Tex; cd05685 552526004129 RNA binding site [nucleotide binding]; other site 552526004130 Transposase [DNA replication, recombination, and repair]; Region: COG5421 552526004131 Transposase [DNA replication, recombination, and repair]; Region: COG5421 552526004132 phosphonoacetaldehyde hydrolase; Region: phosphonatase; TIGR01422 552526004133 phosphate transporter ATP-binding protein; Provisional; Region: PRK14240 552526004134 ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260 552526004135 Walker A/P-loop; other site 552526004136 ATP binding site [chemical binding]; other site 552526004137 Q-loop/lid; other site 552526004138 ABC transporter signature motif; other site 552526004139 Walker B; other site 552526004140 D-loop; other site 552526004141 H-loop/switch region; other site 552526004142 phosphate ABC transporter, permease protein PstA; Region: 3a0107s02c; TIGR00974 552526004143 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 552526004144 dimer interface [polypeptide binding]; other site 552526004145 conserved gate region; other site 552526004146 putative PBP binding loops; other site 552526004147 ABC-ATPase subunit interface; other site 552526004148 ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstC; COG0573 552526004149 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 552526004150 dimer interface [polypeptide binding]; other site 552526004151 conserved gate region; other site 552526004152 putative PBP binding loops; other site 552526004153 ABC-ATPase subunit interface; other site 552526004154 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 552526004155 PBP superfamily domain; Region: PBP_like_2; cl17296 552526004156 ABC-type phosphate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: PstS; COG0226 552526004157 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 552526004158 dimer interface [polypeptide binding]; other site 552526004159 phosphorylation site [posttranslational modification] 552526004160 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 552526004161 ATP binding site [chemical binding]; other site 552526004162 Mg2+ binding site [ion binding]; other site 552526004163 G-X-G motif; other site 552526004164 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 552526004165 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 552526004166 active site 552526004167 phosphorylation site [posttranslational modification] 552526004168 intermolecular recognition site; other site 552526004169 dimerization interface [polypeptide binding]; other site 552526004170 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 552526004171 DNA binding site [nucleotide binding] 552526004172 Predicted permeases [General function prediction only]; Region: COG0701 552526004173 Domain of unknown function (DUF1980); Region: DUF1980; pfam09323 552526004174 Domain of unknown function (DUF1980); Region: DUF1980; cl01492 552526004175 Beta-glucosidase/6-phospho-beta-glucosidase/beta- galactosidase [Carbohydrate transport and metabolism]; Region: BglB; COG2723 552526004176 beta-galactosidase; Region: BGL; TIGR03356 552526004177 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 552526004178 Phosphotransferase system IIA components [Carbohydrate transport and metabolism]; Region: NagE; COG2190 552526004179 HPr interaction site; other site 552526004180 glycerol kinase (GK) interaction site [polypeptide binding]; other site 552526004181 active site 552526004182 phosphorylation site [posttranslational modification] 552526004183 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 552526004184 active site turn [active] 552526004185 phosphorylation site [posttranslational modification] 552526004186 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 552526004187 transcriptional antiterminator BglG; Provisional; Region: PRK09772 552526004188 CAT RNA binding domain; Region: CAT_RBD; pfam03123 552526004189 PRD domain; Region: PRD; pfam00874 552526004190 PRD domain; Region: PRD; pfam00874 552526004191 signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416 552526004192 SRP54-type protein, helical bundle domain; Region: SRP54_N; pfam02881 552526004193 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 552526004194 P loop; other site 552526004195 GTP binding site [chemical binding]; other site 552526004196 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 552526004197 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 552526004198 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 552526004199 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 552526004200 active site 552526004201 motif I; other site 552526004202 motif II; other site 552526004203 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 552526004204 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 552526004205 putative bacteriocin export ABC transporter, lactococcin 972 group; Region: L_ocin_972_ABC; TIGR03608 552526004206 Walker A/P-loop; other site 552526004207 ATP binding site [chemical binding]; other site 552526004208 Q-loop/lid; other site 552526004209 ABC transporter signature motif; other site 552526004210 Walker B; other site 552526004211 D-loop; other site 552526004212 H-loop/switch region; other site 552526004213 Lipase. Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is "interfacial activation", the process of...; Region: Lipase; cl14883 552526004214 nucleophilic elbow; other site 552526004215 catalytic triad; other site 552526004216 Chromosome segregation ATPases [Cell division and chromosome partitioning]; Region: Smc; COG1196 552526004217 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 552526004218 Walker A/P-loop; other site 552526004219 ATP binding site [chemical binding]; other site 552526004220 Q-loop/lid; other site 552526004221 SMC proteins Flexible Hinge Domain; Region: SMC_hinge; smart00968 552526004222 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 552526004223 ABC transporter signature motif; other site 552526004224 Walker B; other site 552526004225 D-loop; other site 552526004226 H-loop/switch region; other site 552526004227 ribonuclease III; Reviewed; Region: rnc; PRK00102 552526004228 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 552526004229 dimerization interface [polypeptide binding]; other site 552526004230 active site 552526004231 metal binding site [ion binding]; metal-binding site 552526004232 Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048 552526004233 dsRNA binding site [nucleotide binding]; other site 552526004234 M protein trans-acting positive regulator (MGA) PRD domain; Region: PRD_Mga; pfam08270 552526004235 M protein trans-acting positive regulator (MGA) HTH domain; Region: HTH_Mga; pfam08280 552526004236 Mga helix-turn-helix domain; Region: Mga; pfam05043 552526004237 M protein trans-acting positive regulator (MGA) PRD domain; Region: PRD_Mga; pfam08270 552526004238 Metal-dependent hydrolases of the beta-lactamase superfamily I [General function prediction only]; Region: PhnP; COG1235 552526004239 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 552526004240 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: VicK; COG5002 552526004241 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 552526004242 putative active site [active] 552526004243 heme pocket [chemical binding]; other site 552526004244 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 552526004245 dimer interface [polypeptide binding]; other site 552526004246 phosphorylation site [posttranslational modification] 552526004247 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 552526004248 ATP binding site [chemical binding]; other site 552526004249 Mg2+ binding site [ion binding]; other site 552526004250 G-X-G motif; other site 552526004251 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 552526004252 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 552526004253 active site 552526004254 phosphorylation site [posttranslational modification] 552526004255 intermolecular recognition site; other site 552526004256 dimerization interface [polypeptide binding]; other site 552526004257 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 552526004258 DNA binding site [nucleotide binding] 552526004259 Protein of unknown function (DUF3114); Region: DUF3114; pfam11311 552526004260 acyl-CoA synthetase; Validated; Region: PRK07638 552526004261 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 552526004262 AMP binding site [chemical binding]; other site 552526004263 active site 552526004264 acyl-activating enzyme (AAE) consensus motif; other site 552526004265 CoA binding site [chemical binding]; other site 552526004266 acetyl-CoA acetyltransferases; Region: AcCoA-C-Actrans; TIGR01930 552526004267 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 552526004268 dimer interface [polypeptide binding]; other site 552526004269 active site 552526004270 ABC-2 family transporter protein; Region: ABC2_membrane_6; cl01496 552526004271 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4587 552526004272 ABC-2 family transporter protein; Region: ABC2_membrane_6; cl01496 552526004273 ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: COG4586 552526004274 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 552526004275 Walker A/P-loop; other site 552526004276 ATP binding site [chemical binding]; other site 552526004277 Q-loop/lid; other site 552526004278 ABC transporter signature motif; other site 552526004279 Walker B; other site 552526004280 D-loop; other site 552526004281 H-loop/switch region; other site 552526004282 threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK00413 552526004283 TGS _ThrRS_N: ThrRS (threonyl-tRNA Synthetase) is a class II tRNA synthetase that couples threonine to its cognate tRNA. In addition to its catalytic and anticodon-binding domains, ThrRS has an N-terminal TGS domain, named after the ThrRS, GTPase, and...; Region: TGS_ThrRS_N; cd01667 552526004284 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 552526004285 Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771 552526004286 active site 552526004287 dimer interface [polypeptide binding]; other site 552526004288 motif 1; other site 552526004289 motif 2; other site 552526004290 motif 3; other site 552526004291 ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860 552526004292 anticodon binding site; other site 552526004293 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 552526004294 This family is most closely related to the GT1 family of glycosyltransferases. UDP-glucose-diacylglycerol glucosyltransferase (UGDG; also known as 1,2-diacylglycerol 3-glucosyltransferase) catalyzes the transfer of glucose from UDP-glucose to 1; Region: GT1_UGDG_like; cd03817 552526004295 putative ADP-binding pocket [chemical binding]; other site 552526004296 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 552526004297 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 552526004298 cytoplasmic alpha-amylase; Reviewed; Region: PRK09441 552526004299 Alpha amylase catalytic domain found in bacterial and fungal Alpha amylases (also called 1,4-alpha-D-glucan-4-glucanohydrolase); Region: AmyAc_bac_fung_AmyA; cd11318 552526004300 active site 552526004301 Na/Ca binding site [ion binding]; other site 552526004302 catalytic site [active] 552526004303 Domain of unknown function (DUF1939); Region: DUF1939; pfam09154 552526004304 catabolite control protein A; Region: ccpA; TIGR01481 552526004305 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 552526004306 DNA binding site [nucleotide binding] 552526004307 domain linker motif; other site 552526004308 Ligand-binding domain of the catabolite control protein A (CcpA), which functions as the major transcriptional regulator of carbon catabolite repression/regulation; Region: PBP1_CcpA_like; cd06298 552526004309 dimerization interface [polypeptide binding]; other site 552526004310 effector binding site; other site 552526004311 NAD(P)H:FMN oxidoreductase family. This domain catalyzes the reduction of flavin, nitrocompound, quinones and azo compounds using NADH or NADPH as an electron donor. The enzyme is a homodimer, and each monomer binds a FMN as co-factor. This family...; Region: NfsB_like_nitroreductase; cd02149 552526004312 dimer interface [polypeptide binding]; other site 552526004313 FMN binding site [chemical binding]; other site 552526004314 undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714 552526004315 Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187 552526004316 Ligand binding site; other site 552526004317 Putative Catalytic site; other site 552526004318 DXD motif; other site 552526004319 Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294 552526004320 SmpB-tmRNA interface; other site 552526004321 ribonuclease R; Region: RNase_R; TIGR02063 552526004322 Ribonuclease B OB domain; Region: OB_RNB; pfam08206 552526004323 RNB domain; Region: RNB; pfam00773 552526004324 S1_RNase_R: RNase R C-terminal S1 domain. RNase R is a processive 3' to 5' exoribonuclease, which is a homolog of RNase II. RNase R degrades RNA with secondary structure having a 3' overhang of at least 7 nucleotides. RNase R and PNPase...; Region: S1_RNase_R; cd04471 552526004325 RNA binding site [nucleotide binding]; other site 552526004326 preprotein translocase subunit SecG; Reviewed; Region: secG; PRK06870 552526004327 Fibronectin-binding protein signal sequence; Region: Fb_signal; pfam08341 552526004328 TQXA domain; Region: TQXA_dom; TIGR03934 552526004329 Collagen triple helix repeat (20 copies); Region: Collagen; pfam01391 552526004330 Dephospho-CoA kinase [Coenzyme metabolism]; Region: CoaE; COG0237 552526004331 Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022 552526004332 CoA-binding site [chemical binding]; other site 552526004333 ATP-binding [chemical binding]; other site 552526004334 formamidopyrimidine/5-formyluracil/ 5-hydroxymethyluracil DNA glycosylase; Validated; Region: PRK01103 552526004335 N-terminal domain of Escherichia coli Fpg1/MutM and related bacterial DNA glycosylases; Region: EcFpg-like_N; cd08966 552526004336 DNA binding site [nucleotide binding] 552526004337 catalytic residue [active] 552526004338 H2TH interface [polypeptide binding]; other site 552526004339 putative catalytic residues [active] 552526004340 turnover-facilitating residue; other site 552526004341 intercalation triad [nucleotide binding]; other site 552526004342 8OG recognition residue [nucleotide binding]; other site 552526004343 putative reading head residues; other site 552526004344 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 552526004345 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 552526004346 Glycosyl hydrolases family 35; Region: Glyco_hydro_35; pfam01301 552526004347 YSIRK type signal peptide; Region: YSIRK_signal; cl04650 552526004348 Laminarinase, member of the glycosyl hydrolase family 16; Region: GH16_laminarinase_like; cd08023 552526004349 active site 552526004350 catalytic residues [active] 552526004351 Pentraxins are plasma proteins characterized by their pentameric discoid assembly and their Ca2+ dependent ligand binding, such as Serum amyloid P component (SAP) and C-reactive Protein (CRP), which are cytokine-inducible acute-phase proteins implicated...; Region: PTX; cl00102 552526004352 Sialidases or neuraminidases function to bind and hydrolyze terminal sialic acid residues from various glycoconjugates as well as playing roles in pathogenesis, bacterial nutrition and cellular interactions. They have a six-bladed, beta-propeller fold...; Region: Sialidase; cd00260 552526004353 Sialidases or neuraminidases function to bind and hydrolyze terminal sialic acid residues from various glycoconjugates as well as playing roles in pathogenesis, bacterial nutrition and cellular interactions. They have a six-bladed, beta-propeller fold...; Region: Sialidase; cd00260 552526004354 Asp-box motif; other site 552526004355 Asp-box motif; other site 552526004356 catalytic site [active] 552526004357 Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455 552526004358 cellobiose phosphotransferase system IIC component; Reviewed; Region: celD; PRK09592 552526004359 Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455 552526004360 cellobiose phosphotransferase system IIC component; Reviewed; Region: celD; PRK09592 552526004361 PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_lac; cd00215 552526004362 active site 552526004363 methionine cluster; other site 552526004364 phosphorylation site [posttranslational modification] 552526004365 metal binding site [ion binding]; metal-binding site 552526004366 PTS_IIB_chitobiose_lichenan: subunit IIB of enzyme II (EII) of the N,N-diacetylchitobiose-specific and lichenan-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In these systems, EII is either a lichenan- or an N; Region: PTS_IIB_chitobiose_lichenan; cd05564 552526004367 active site 552526004368 P-loop; other site 552526004369 phosphorylation site [posttranslational modification] 552526004370 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 552526004371 MarR family; Region: MarR_2; cl17246 552526004372 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 552526004373 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 552526004374 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_18; cd04677 552526004375 nudix motif; other site 552526004376 H+/gluconate symporter and related permeases [Carbohydrate transport and metabolism / Amino acid transport and metabolism]; Region: GntT; COG2610 552526004377 fructuronate transporter; Provisional; Region: PRK10034; cl15264 552526004378 3-hydroxybutyrate dehydrogenase; Provisional; Region: PRK12429 552526004379 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 552526004380 NAD(P) binding site [chemical binding]; other site 552526004381 active site 552526004382 3-oxoacid CoA-transferase, B subunit; Region: pcaJ_scoB_fam; TIGR02428 552526004383 Acyl CoA:acetate/3-ketoacid CoA transferase, alpha subunit [Lipid metabolism]; Region: AtoD; COG1788 552526004384 putative acyltransferase; Provisional; Region: PRK05790 552526004385 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 552526004386 dimer interface [polypeptide binding]; other site 552526004387 active site 552526004388 DNA-binding transcriptional regulator HcaR; Provisional; Region: PRK09906 552526004389 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 552526004390 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 552526004391 dimerization interface [polypeptide binding]; other site 552526004392 GTPase Era; Reviewed; Region: era; PRK00089 552526004393 E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163 552526004394 G1 box; other site 552526004395 GTP/Mg2+ binding site [chemical binding]; other site 552526004396 Switch I region; other site 552526004397 G2 box; other site 552526004398 Switch II region; other site 552526004399 G3 box; other site 552526004400 G4 box; other site 552526004401 G5 box; other site 552526004402 KH domain; Region: KH_2; pfam07650 552526004403 Diacylglycerol kinase [Cell envelope biogenesis, outer membrane]; Region: DgkA; COG0818 552526004404 metal-binding heat shock protein; Provisional; Region: PRK00016 552526004405 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 552526004406 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 552526004407 Uncharacterized subfamily of Uracil-DNA glycosylases; Region: UDG_like_1; cd10033 552526004408 putative uracil binding site [chemical binding]; other site 552526004409 putative active site [active] 552526004410 Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702 552526004411 PhoH-like protein; Region: PhoH; pfam02562 552526004412 hypothetical protein; Provisional; Region: PRK13672 552526004413 methionine sulfoxide reductase A; Provisional; Region: PRK14054 552526004414 Predicted RNA-bindining protein (contains S1 and HTH domains) [General function prediction only]; Region: COG2996 552526004415 S1 domain; Region: S1_2; pfam13509 552526004416 Ribosomal protein S1-like RNA-binding domain; Region: S1; smart00316 552526004417 ribosome recycling factor; Reviewed; Region: frr; PRK00083 552526004418 Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation. Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520 552526004419 hinge region; other site 552526004420 UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254 552526004421 putative nucleotide binding site [chemical binding]; other site 552526004422 uridine monophosphate binding site [chemical binding]; other site 552526004423 homohexameric interface [polypeptide binding]; other site 552526004424 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 552526004425 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 552526004426 Walker A/P-loop; other site 552526004427 ATP binding site [chemical binding]; other site 552526004428 Q-loop/lid; other site 552526004429 ABC transporter signature motif; other site 552526004430 Walker B; other site 552526004431 D-loop; other site 552526004432 H-loop/switch region; other site 552526004433 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 552526004434 nickel import ATP-binding protein NikD; Region: nickel_nikD; TIGR02770 552526004435 Walker A/P-loop; other site 552526004436 ATP binding site [chemical binding]; other site 552526004437 Q-loop/lid; other site 552526004438 ABC transporter signature motif; other site 552526004439 Walker B; other site 552526004440 D-loop; other site 552526004441 H-loop/switch region; other site 552526004442 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 552526004443 nickel ABC transporter, permease subunit NikC; Region: nickel_nikC; TIGR02790 552526004444 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 552526004445 dimer interface [polypeptide binding]; other site 552526004446 conserved gate region; other site 552526004447 putative PBP binding loops; other site 552526004448 ABC-ATPase subunit interface; other site 552526004449 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 552526004450 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 552526004451 dimer interface [polypeptide binding]; other site 552526004452 conserved gate region; other site 552526004453 putative PBP binding loops; other site 552526004454 ABC-ATPase subunit interface; other site 552526004455 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 552526004456 The substrate-binding component of an ABC-type nickel import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA; cd08489 552526004457 substrate binding site [chemical binding]; other site 552526004458 TQXA domain; Region: TQXA_dom; TIGR03934 552526004459 Collagen triple helix repeat (20 copies); Region: Collagen; pfam01391 552526004460 Ribosomal protein L1. The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA. In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403 552526004461 mRNA/rRNA interface [nucleotide binding]; other site 552526004462 50S ribosomal protein L11; Validated; Region: rplK; PRK00140 552526004463 Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349 552526004464 23S rRNA interface [nucleotide binding]; other site 552526004465 L7/L12 interface [polypeptide binding]; other site 552526004466 putative thiostrepton binding site; other site 552526004467 L25 interface [polypeptide binding]; other site 552526004468 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 552526004469 Helix-turn-helix domain; Region: HTH_38; pfam13936 552526004470 Integrase core domain; Region: rve; pfam00665 552526004471 Transcriptional regulators [Transcription]; Region: PurR; COG1609 552526004472 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 552526004473 DNA binding site [nucleotide binding] 552526004474 domain linker motif; other site 552526004475 Protein of unknown function (DUF3397); Region: DUF3397; pfam11877 552526004476 DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674 552526004477 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 552526004478 Ftsk gamma domain; Region: Ftsk_gamma; pfam09397 552526004479 Peptidyl-prolyl cis-trans isomerase (rotamase) - cyclophilin family [Posttranslational modification, protein turnover, chaperones]; Region: PpiB; COG0652 552526004480 active site 552526004481 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 552526004482 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 552526004483 ABC-ATPase subunit interface; other site 552526004484 dimer interface [polypeptide binding]; other site 552526004485 putative PBP binding regions; other site 552526004486 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 552526004487 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 552526004488 ABC-type metal ion transport system, periplasmic component/surface adhesin [Inorganic ion transport and metabolism]; Region: LraI; COG0803 552526004489 Metal binding protein PsaA. These proteins have been shown to function as initial receptors in ABC transport of Mn2+ and as surface adhesins in some eubacterial species. They belong to the TroA superfamily of periplasmic metal binding proteins that...; Region: PsaA; cd01137 552526004490 metal binding site [ion binding]; metal-binding site 552526004491 Mn-dependent transcriptional regulator [Transcription]; Region: TroR; COG1321 552526004492 Iron dependent repressor, N-terminal DNA binding domain; Region: Fe_dep_repress; pfam01325 552526004493 Iron dependent repressor, metal binding and dimerisation domain; Region: Fe_dep_repr_C; pfam02742 552526004494 FeoA domain; Region: FeoA; pfam04023 552526004495 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Validated; Region: PRK05584 552526004496 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Region: MTA/SAH-Nsdase; TIGR01704 552526004497 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 552526004498 dimer interface [polypeptide binding]; other site 552526004499 ADP-ribose binding site [chemical binding]; other site 552526004500 active site 552526004501 nudix motif; other site 552526004502 metal binding site [ion binding]; metal-binding site 552526004503 bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase; Provisional; Region: glmU; PRK14354 552526004504 N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540 552526004505 Substrate binding site; other site 552526004506 Mg++ binding site; other site 552526004507 N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353 552526004508 active site 552526004509 substrate binding site [chemical binding]; other site 552526004510 CoA binding site [chemical binding]; other site 552526004511 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 552526004512 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 552526004513 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 552526004514 ASC-1 homology domain, subfamily similar to Enterococcus faecalis Ef3133. The ASCH domain, a small beta-barrel domain found in all three kingdoms of life, resembles the RNA-binding PUA domain and may also interact with RNA. ASCH has been proposed to...; Region: ASCH_Ef3133_like; cd06553 552526004515 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK06550 552526004516 classical (c) SDRs; Region: SDR_c; cd05233 552526004517 NAD(P) binding site [chemical binding]; other site 552526004518 active site 552526004519 Protein of unknown function (DUF2829); Region: DUF2829; pfam11195 552526004520 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 552526004521 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 552526004522 valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729 552526004523 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 552526004524 active site 552526004525 HIGH motif; other site 552526004526 nucleotide binding site [chemical binding]; other site 552526004527 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 552526004528 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 552526004529 active site 552526004530 KMSKS motif; other site 552526004531 Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962 552526004532 tRNA binding surface [nucleotide binding]; other site 552526004533 anticodon binding site; other site 552526004534 Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458 552526004535 Cytidylate kinase-like family; Region: Cytidylate_kin2; pfam13189 552526004536 AAA domain; Region: AAA_17; pfam13207 552526004537 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 552526004538 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 552526004539 hypothetical protein; Provisional; Region: PRK07758 552526004540 Domain of unknown function (DUF1912); Region: DUF1912; pfam08930 552526004541 3-deoxy-7-phosphoheptulonate synthase; Provisional; Region: PRK13397 552526004542 3-deoxy-D-arabino-heptulosonate 7-phosphate (DAHP) synthase [Amino acid transport and metabolism]; Region: AroA; COG2876 552526004543 Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195 552526004544 active site 552526004545 dimer interface [polypeptide binding]; other site 552526004546 metal binding site [ion binding]; metal-binding site 552526004547 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 552526004548 Helix-turn-helix domain; Region: HTH_28; pfam13518 552526004549 Helix-turn-helix domain; Region: HTH_28; pfam13518 552526004550 Winged helix-turn helix; Region: HTH_29; pfam13551 552526004551 HTH-like domain; Region: HTH_21; pfam13276 552526004552 Integrase core domain; Region: rve; pfam00665 552526004553 Integrase core domain; Region: rve_2; pfam13333 552526004554 Phosphorylase superfamily; Region: PNP_UDP_1; pfam01048 552526004555 shikimate 5-dehydrogenase; Provisional; Region: PRK12548 552526004556 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 552526004557 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 552526004558 shikimate binding site; other site 552526004559 NAD(P) binding site [chemical binding]; other site 552526004560 Beta-galactosidase/beta-glucuronidase [Carbohydrate transport and metabolism]; Region: LacZ; COG3250 552526004561 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837 552526004562 Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703 552526004563 Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836 552526004564 Response regulator containing CheY-like receiver domain and AraC-type DNA-binding domain [Signal transduction mechanisms]; Region: COG4753 552526004565 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 552526004566 active site 552526004567 phosphorylation site [posttranslational modification] 552526004568 intermolecular recognition site; other site 552526004569 dimerization interface [polypeptide binding]; other site 552526004570 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 552526004571 Predicted signal transduction protein with a C-terminal ATPase domain [Signal transduction mechanisms]; Region: COG2972 552526004572 HAMP (Histidine kinases, Adenylyl cyclases, Methyl binding proteins, Phosphatases) domain; Region: HAMP; smart00304 552526004573 dimerization interface [polypeptide binding]; other site 552526004574 Histidine kinase; Region: His_kinase; pfam06580 552526004575 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 552526004576 ATP binding site [chemical binding]; other site 552526004577 Mg2+ binding site [ion binding]; other site 552526004578 G-X-G motif; other site 552526004579 Predicted integral membrane protein [Function unknown]; Region: COG5578 552526004580 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 552526004581 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 552526004582 Domain of unknown function (DUF3502); Region: DUF3502; pfam12010 552526004583 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 552526004584 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 552526004585 dimer interface [polypeptide binding]; other site 552526004586 conserved gate region; other site 552526004587 putative PBP binding loops; other site 552526004588 ABC-ATPase subunit interface; other site 552526004589 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 552526004590 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 552526004591 ABC-ATPase subunit interface; other site 552526004592 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 552526004593 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 552526004594 nucleotide binding site [chemical binding]; other site 552526004595 Putative alpha-1,2-mannosidase [Carbohydrate transport and metabolism]; Region: COG3537 552526004596 Glycosyl hydrolase family 92; Region: Glyco_hydro_92; pfam07971 552526004597 Beta-glucosidase/6-phospho-beta-glucosidase/beta- galactosidase [Carbohydrate transport and metabolism]; Region: BglB; COG2723 552526004598 beta-galactosidase; Region: BGL; TIGR03356 552526004599 beta-N-acetylglucosaminidase; Region: NAGidase; pfam07555 552526004600 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 552526004601 DNA-binding site [nucleotide binding]; DNA binding site 552526004602 Transcriptional regulators [Transcription]; Region: PurR; COG1609 552526004603 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 552526004604 ligand binding site [chemical binding]; other site 552526004605 dimerization interface [polypeptide binding]; other site 552526004606 Uncharacterized conserved protein [Function unknown]; Region: COG3538 552526004607 Protein of unknown function (DUF1237); Region: DUF1237; pfam06824 552526004608 Alpha-mannosidase [Carbohydrate transport and metabolism]; Region: AMS1; COG0383 552526004609 N-terminal catalytic domain of SPGH38, a putative alpha-mannosidase of Streptococcus pyogenes, and its prokaryotic homologs; glycoside hydrolase family 38 (GH38); Region: GH38N_AMII_SpGH38_like; cd10814 552526004610 homodimer interface [polypeptide binding]; other site 552526004611 active site 552526004612 catalytic site [active] 552526004613 Alpha mannosidase, middle domain; Region: Alpha-mann_mid; smart00872 552526004614 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 552526004615 putative bacteriocin export ABC transporter, lactococcin 972 group; Region: L_ocin_972_ABC; TIGR03608 552526004616 Walker A/P-loop; other site 552526004617 ATP binding site [chemical binding]; other site 552526004618 Q-loop/lid; other site 552526004619 ABC transporter signature motif; other site 552526004620 Walker B; other site 552526004621 D-loop; other site 552526004622 H-loop/switch region; other site 552526004623 bacteriocin-associated integral membrane (putative immunity) protein; Region: bact_immun_7tm; TIGR01654 552526004624 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 552526004625 non-specific DNA binding site [nucleotide binding]; other site 552526004626 salt bridge; other site 552526004627 sequence-specific DNA binding site [nucleotide binding]; other site 552526004628 Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247 552526004629 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 552526004630 Coenzyme A binding pocket [chemical binding]; other site 552526004631 Enterocin A Immunity; Region: EntA_Immun; pfam08951 552526004632 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 552526004633 Transposase; Region: HTH_Tnp_1; cl17663 552526004634 putative transposase OrfB; Reviewed; Region: PHA02517 552526004635 HTH-like domain; Region: HTH_21; pfam13276 552526004636 Integrase core domain; Region: rve; pfam00665 552526004637 Integrase core domain; Region: rve_2; pfam13333 552526004638 Enterocin A Immunity; Region: EntA_Immun; pfam08951 552526004639 A sub-family of peptidase family C39. Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various...; Region: Peptidase_C39B; cd02418 552526004640 ABC-type bacteriocin transporter; Region: bacteriocin_ABC; TIGR01193 552526004641 putative active site [active] 552526004642 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 552526004643 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 552526004644 Walker A/P-loop; other site 552526004645 ATP binding site [chemical binding]; other site 552526004646 Q-loop/lid; other site 552526004647 ABC transporter signature motif; other site 552526004648 Walker B; other site 552526004649 D-loop; other site 552526004650 H-loop/switch region; other site 552526004651 bacteriocin secretion accessory protein; Region: bacteriocin_acc; TIGR01000 552526004652 HlyD family secretion protein; Region: HlyD_3; pfam13437 552526004653 Predicted signal transduction protein with a C-terminal ATPase domain [Signal transduction mechanisms]; Region: COG2972 552526004654 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 552526004655 ATP binding site [chemical binding]; other site 552526004656 Mg2+ binding site [ion binding]; other site 552526004657 G-X-G motif; other site 552526004658 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 552526004659 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 552526004660 active site 552526004661 phosphorylation site [posttranslational modification] 552526004662 intermolecular recognition site; other site 552526004663 dimerization interface [polypeptide binding]; other site 552526004664 LytTr DNA-binding domain; Region: LytTR; pfam04397 552526004665 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 552526004666 Helix-turn-helix domain; Region: HTH_38; pfam13936 552526004667 Integrase core domain; Region: rve; pfam00665 552526004668 Bacteriocin class II with double-glycine leader peptide; Region: Bacteriocin_IIc; pfam10439 552526004669 TRAM domain; Region: TRAM; pfam01938 552526004670 SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase [Translation, ribosomal structure and biogenesis]; Region: TrmA; COG2265 552526004671 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 552526004672 S-adenosylmethionine binding site [chemical binding]; other site 552526004673 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 552526004674 Helix-turn-helix domain; Region: HTH_28; pfam13518 552526004675 putative transposase OrfB; Reviewed; Region: PHA02517 552526004676 HTH-like domain; Region: HTH_21; pfam13276 552526004677 Integrase core domain; Region: rve; pfam00665 552526004678 Integrase core domain; Region: rve_2; pfam13333 552526004679 Cro/C1-type HTH DNA-binding domain; Region: HTH_26; pfam13443 552526004680 Site-specific DNA methylase [DNA replication, recombination, and repair]; Region: Dcm; COG0270 552526004681 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315 552526004682 cofactor binding site; other site 552526004683 DNA binding site [nucleotide binding] 552526004684 substrate interaction site [chemical binding]; other site 552526004685 Methyltransferase domain; Region: Methyltransf_26; pfam13659 552526004686 Domain of unknown function (DUF1837); Region: DUF1837; pfam08878 552526004687 DEAD-like helicases superfamily; Region: DEXDc; smart00487 552526004688 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 552526004689 ATP binding site [chemical binding]; other site 552526004690 putative Mg++ binding site [ion binding]; other site 552526004691 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 552526004692 nucleotide binding region [chemical binding]; other site 552526004693 ATP-binding site [chemical binding]; other site 552526004694 recombination regulator RecX; Provisional; Region: recX; PRK14135 552526004695 hypothetical protein; Provisional; Region: PRK13662 552526004696 Staphylococcal protein of unknown function (DUF960); Region: DUF960; pfam06124 552526004697 Helix-turn-helix domain of transposase family ISL3; Region: HTH_Tnp_ISL3; pfam13542 552526004698 RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552 552526004699 30S subunit binding site; other site 552526004700 comF family protein; Region: comF; TIGR00201 552526004701 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 552526004702 active site 552526004703 Superfamily II DNA/RNA helicase required for DNA uptake (late competence protein) [DNA replication, recombination, and repair]; Region: comFA; COG4098 552526004704 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 552526004705 ATP binding site [chemical binding]; other site 552526004706 putative Mg++ binding site [ion binding]; other site 552526004707 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 552526004708 nucleotide binding region [chemical binding]; other site 552526004709 ATP-binding site [chemical binding]; other site 552526004710 Uncharacterized conserved protein [Function unknown]; Region: COG1739 552526004711 Uncharacterized protein family UPF0029; Region: UPF0029; pfam01205 552526004712 Domain of unknown function (DUF1949); Region: DUF1949; pfam09186 552526004713 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 552526004714 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 552526004715 dimer interface [polypeptide binding]; other site 552526004716 pyridoxal 5'-phosphate binding site [chemical binding]; other site 552526004717 catalytic residue [active] 552526004718 hypothetical protein; Provisional; Region: PRK07252 552526004719 Predicted RNA binding protein (contains ribosomal protein S1 domain) [Translation, ribosomal structure and biogenesis]; Region: VacB; COG1098 552526004720 RNA binding site [nucleotide binding]; other site 552526004721 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 552526004722 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 552526004723 active site 552526004724 motif I; other site 552526004725 motif II; other site 552526004726 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 552526004727 Peptidyl-prolyl cis-trans isomerase (rotamase) - cyclophilin family [Posttranslational modification, protein turnover, chaperones]; Region: PpiB; COG0652 552526004728 active site 552526004729 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 552526004730 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 552526004731 active site 552526004732 phosphorylation site [posttranslational modification] 552526004733 intermolecular recognition site; other site 552526004734 dimerization interface [polypeptide binding]; other site 552526004735 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 552526004736 DNA binding residues [nucleotide binding] 552526004737 dimerization interface [polypeptide binding]; other site 552526004738 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 552526004739 Histidine kinase; Region: HisKA_3; pfam07730 552526004740 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 552526004741 ATP binding site [chemical binding]; other site 552526004742 Mg2+ binding site [ion binding]; other site 552526004743 G-X-G motif; other site 552526004744 Predicted membrane protein [Function unknown]; Region: COG4758 552526004745 Cell wall-active antibiotics response protein (DUF2154); Region: DUF2154; pfam09922 552526004746 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 552526004747 Catalytic domain of Protein Kinases; Region: PKc; cd00180 552526004748 active site 552526004749 ATP binding site [chemical binding]; other site 552526004750 substrate binding site [chemical binding]; other site 552526004751 activation loop (A-loop); other site 552526004752 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2815 552526004753 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 552526004754 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 552526004755 PASTA domain; Region: PASTA; pfam03793 552526004756 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143 552526004757 active site 552526004758 16S rRNA methyltransferase B; Provisional; Region: PRK14902 552526004759 NusB family; Region: NusB; pfam01029 552526004760 putative RNA binding site [nucleotide binding]; other site 552526004761 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 552526004762 S-adenosylmethionine binding site [chemical binding]; other site 552526004763 methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005 552526004764 Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646 552526004765 putative active site [active] 552526004766 substrate binding site [chemical binding]; other site 552526004767 putative cosubstrate binding site; other site 552526004768 catalytic site [active] 552526004769 C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704 552526004770 substrate binding site [chemical binding]; other site 552526004771 Primosomal protein N' (replication factor Y) - superfamily II helicase [DNA replication, recombination, and repair]; Region: PriA; COG1198 552526004772 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 552526004773 ATP binding site [chemical binding]; other site 552526004774 putative Mg++ binding site [ion binding]; other site 552526004775 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 552526004776 ATP-binding site [chemical binding]; other site 552526004777 DNA-directed RNA polymerase subunit omega; Reviewed; Region: rpoZ; PRK00392 552526004778 Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194 552526004779 Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071 552526004780 catalytic site [active] 552526004781 G-X2-G-X-G-K; other site 552526004782 hypothetical protein; Provisional; Region: PRK00106 552526004783 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 552526004784 Zn2+ binding site [ion binding]; other site 552526004785 Mg2+ binding site [ion binding]; other site 552526004786 S-ribosylhomocysteinase; Provisional; Region: PRK02260 552526004787 Predicted N6-adenine-specific DNA methylase [DNA replication, recombination, and repair]; Region: COG0116 552526004788 THUMP domain associated with S-adenosylmethionine-dependent methyltransferases; Region: THUMP_AdoMetMT; cd11715 552526004789 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 552526004790 cell division protein GpsB; Provisional; Region: PRK14127 552526004791 DivIVA domain; Region: DivI1A_domain; TIGR03544 552526004792 hypothetical protein; Provisional; Region: PRK13660 552526004793 Holliday junction-specific endonuclease; Reviewed; Region: recU; PRK02234 552526004794 Membrane carboxypeptidase (penicillin-binding protein) [Cell envelope biogenesis, outer membrane]; Region: MrcB; COG0744 552526004795 Transglycosylase; Region: Transgly; pfam00912 552526004796 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 552526004797 Peptidase C1B subfamily (MEROPS database nomenclature); composed of eukaryotic bleomycin hydrolases (BH) and bacterial aminopeptidases C (pepC). The proteins of this subfamily contain a large insert relative to the C1A peptidase (papain) subfamily. BH is...; Region: Peptidase_C1B; cd00585 552526004798 trimer interface [polypeptide binding]; other site 552526004799 active site 552526004800 G bulge; other site 552526004801 NAD synthase [Coenzyme metabolism]; Region: NadE; COG0171 552526004802 NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553 552526004803 homodimer interface [polypeptide binding]; other site 552526004804 NAD binding pocket [chemical binding]; other site 552526004805 ATP binding pocket [chemical binding]; other site 552526004806 Mg binding site [ion binding]; other site 552526004807 active-site loop [active] 552526004808 nicotinate phosphoribosyltransferase; Validated; Region: PRK09243 552526004809 Nicotinate phosphoribosyltransferase (NAPRTase), subgroup A. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting, reaction...; Region: NAPRTase_A; cd01570 552526004810 active site 552526004811 Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113 552526004812 thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292 552526004813 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 552526004814 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 552526004815 Protein of unknown function (DUF4059); Region: DUF4059; pfam13268 552526004816 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 552526004817 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 552526004818 Walker A/P-loop; other site 552526004819 ATP binding site [chemical binding]; other site 552526004820 Q-loop/lid; other site 552526004821 ABC transporter signature motif; other site 552526004822 Walker B; other site 552526004823 D-loop; other site 552526004824 H-loop/switch region; other site 552526004825 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 552526004826 dimer interface [polypeptide binding]; other site 552526004827 conserved gate region; other site 552526004828 putative PBP binding loops; other site 552526004829 ABC-ATPase subunit interface; other site 552526004830 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 552526004831 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 552526004832 substrate binding pocket [chemical binding]; other site 552526004833 membrane-bound complex binding site; other site 552526004834 hinge residues; other site 552526004835 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 552526004836 DEAD-like helicases superfamily; Region: DEXDc; smart00487 552526004837 ATP binding site [chemical binding]; other site 552526004838 Mg++ binding site [ion binding]; other site 552526004839 motif III; other site 552526004840 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 552526004841 nucleotide binding region [chemical binding]; other site 552526004842 ATP-binding site [chemical binding]; other site 552526004843 phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108 552526004844 Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852 552526004845 Mg++ binding site [ion binding]; other site 552526004846 putative catalytic motif [active] 552526004847 putative substrate binding site [chemical binding]; other site 552526004848 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 552526004849 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 552526004850 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 552526004851 PASTA domain of PBP2x-like proteins, first repeat. Penicillin-binding proteins (PBPs) are the major targets for beta-lactam antibiotics, like penicillins and cephalosporins. Beta-lactam antibiotics specifically inhibit transpeptidase activity by...; Region: PASTA_Pbp2x-like_1; cd06576 552526004852 PASTA domain of PBP2x-like proteins, second repeat. Penicillin-binding proteins (PBPs) are the major targets for beta-lactam antibiotics, like penicillins and cephalosporins. Beta-lactam antibiotics specifically inhibit transpeptidase activity by...; Region: PASTA_Pbp2x-like_2; cd06575 552526004853 Protein required for the initiation of cell division [Cell division and chromosome partitioning]; Region: FtsL; COG4839 552526004854 Predicted S-adenosylmethionine-dependent methyltransferase involved in cell envelope biogenesis [Cell envelope biogenesis, outer membrane]; Region: COG0275 552526004855 MraW methylase family; Region: Methyltransf_5; pfam01795 552526004856 integral membrane protein, PqiA family; Region: pqiA_fam; TIGR00155 552526004857 Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079 552526004858 gamma-glutamyl phosphate reductase; Region: proA; TIGR00407 552526004859 putative catalytic cysteine [active] 552526004860 Glutamate 5-kinase [Amino acid transport and metabolism]; Region: ProB; COG0263 552526004861 AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242 552526004862 nucleotide binding site [chemical binding]; other site 552526004863 homotetrameric interface [polypeptide binding]; other site 552526004864 putative phosphate binding site [ion binding]; other site 552526004865 putative allosteric binding site; other site 552526004866 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 552526004867 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 552526004868 ABC transporter signature motif; other site 552526004869 Walker B; other site 552526004870 D-loop; other site 552526004871 H-loop/switch region; other site 552526004872 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 552526004873 Walker A/P-loop; other site 552526004874 ATP binding site [chemical binding]; other site 552526004875 Q-loop/lid; other site 552526004876 Enterocin A Immunity; Region: EntA_Immun; pfam08951 552526004877 Transketolase [Carbohydrate transport and metabolism]; Region: TktA; COG0021 552526004878 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 552526004879 TPP-binding site [chemical binding]; other site 552526004880 dimer interface [polypeptide binding]; other site 552526004881 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 552526004882 PYR/PP interface [polypeptide binding]; other site 552526004883 dimer interface [polypeptide binding]; other site 552526004884 TPP binding site [chemical binding]; other site 552526004885 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 552526004886 Transaldolase-like fructose-6-phosphate aldolases (FSA) found in bacteria and archaea; Region: Transaldolase_FSA; cd00956 552526004887 active site 552526004888 intersubunit interactions; other site 552526004889 catalytic residue [active] 552526004890 glycerol kinase; Provisional; Region: glpK; PRK00047 552526004891 Escherichia coli glycerol kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_EcGK_like; cd07786 552526004892 N- and C-terminal domain interface [polypeptide binding]; other site 552526004893 active site 552526004894 MgATP binding site [chemical binding]; other site 552526004895 catalytic site [active] 552526004896 metal binding site [ion binding]; metal-binding site 552526004897 glycerol binding site [chemical binding]; other site 552526004898 homotetramer interface [polypeptide binding]; other site 552526004899 homodimer interface [polypeptide binding]; other site 552526004900 FBP binding site [chemical binding]; other site 552526004901 protein IIAGlc interface [polypeptide binding]; other site 552526004902 Predicted membrane protein [Function unknown]; Region: COG3212 552526004903 Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413 552526004904 Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413 552526004905 Predicted methyltransferases [General function prediction only]; Region: COG0313 552526004906 Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648 552526004907 putative SAM binding site [chemical binding]; other site 552526004908 putative homodimer interface [polypeptide binding]; other site 552526004909 DNA replication intiation control protein YabA; Reviewed; Region: PRK13169 552526004910 PSP1 C-terminal conserved region; Region: PSP1; cl00770 552526004911 DNA polymerase III subunit delta'; Validated; Region: PRK07276 552526004912 DNA polymerase III subunit delta'; Validated; Region: PRK08485 552526004913 thymidylate kinase; Validated; Region: tmk; PRK00698 552526004914 Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672 552526004915 TMP-binding site; other site 552526004916 ATP-binding site [chemical binding]; other site 552526004917 hypothetical protein; Provisional; Region: PRK02302 552526004918 Protein of unknown function (DUF964); Region: DUF964; pfam06133 552526004919 Protease subunit of ATP-dependent Clp proteases [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: ClpP; COG0740 552526004920 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 552526004921 oligomer interface [polypeptide binding]; other site 552526004922 active site residues [active] 552526004923 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 552526004924 active site 552526004925 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 552526004926 Stage V sporulation protein B, also known as Stage III sporulation protein F, and related proteins; Region: MATE_SpoVB_like; cd13124 552526004927 UDP-N-acetylmuramoylalanyl-D-glutamate--L-lysine ligase; Provisional; Region: PRK14022 552526004928 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 552526004929 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 552526004930 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 552526004931 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 552526004932 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 552526004933 Walker A/P-loop; other site 552526004934 ATP binding site [chemical binding]; other site 552526004935 Q-loop/lid; other site 552526004936 ABC transporter signature motif; other site 552526004937 Walker B; other site 552526004938 D-loop; other site 552526004939 H-loop/switch region; other site 552526004940 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 552526004941 Periplasmic binding protein FeuA. These proteins have predicted to function as initial receptors in ABC transport of metal ions in some eubacterial species. They belong to the TroA superfamily of periplasmic metal binding proteins that share a distinct...; Region: FeuA; cd01138 552526004942 putative ligand binding residues [chemical binding]; other site 552526004943 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 552526004944 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 552526004945 ABC-ATPase subunit interface; other site 552526004946 dimer interface [polypeptide binding]; other site 552526004947 putative PBP binding regions; other site 552526004948 ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779 552526004949 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 552526004950 ABC-ATPase subunit interface; other site 552526004951 dimer interface [polypeptide binding]; other site 552526004952 putative PBP binding regions; other site 552526004953 Domain of unknown function (DUF1803); Region: DUF1803; pfam08820 552526004954 Domain of unknown function (DUF1803); Region: DUF1803; pfam08820 552526004955 putative manganese-dependent inorganic pyrophosphatase; Provisional; Region: PRK05427 552526004956 DHH family; Region: DHH; pfam01368 552526004957 DHHA2 domain; Region: DHHA2; pfam02833 552526004958 pyruvate formate-lyase 1-activating enzyme; Region: PFLA; TIGR02493 552526004959 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 552526004960 FeS/SAM binding site; other site 552526004961 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 552526004962 Domain of unknown function DUF21; Region: DUF21; pfam01595 552526004963 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 552526004964 Transporter associated domain; Region: CorC_HlyC; smart01091 552526004965 Putative rRNA methylase; Region: rRNA_methylase; pfam06962 552526004966 Phosphotransferase enzyme family; Region: APH; pfam01636 552526004967 Aminoglycoside 3'-phosphotransferase (APH). The APH subfamily is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs), RIO kinases, actin-fragmin...; Region: APH; cd05150 552526004968 active site 552526004969 ATP binding site [chemical binding]; other site 552526004970 antibiotic binding site [chemical binding]; other site 552526004971 Predicted Fe-S oxidoreductase [General function prediction only]; Region: COG1242 552526004972 PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392 552526004973 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 552526004974 active site 552526004975 Predicted membrane protein [Function unknown]; Region: COG3601 552526004976 Protein of unknown function (DUF3816); Region: DUF3816; pfam12822 552526004977 Lipase. Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is "interfacial activation", the process of...; Region: Lipase; cl14883 552526004978 nucleophilic elbow; other site 552526004979 catalytic triad; other site 552526004980 Predicted rRNA methylase (SpoU class) [Translation, ribosomal structure and biogenesis]; Region: CspR; COG0219 552526004981 hypothetical protein; Validated; Region: PRK00041 552526004982 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 552526004983 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 552526004984 RNA binding surface [nucleotide binding]; other site 552526004985 Pseudouridine synthases, RsuA subfamily; Region: PseudoU_synth_RsuA_like; cd02870 552526004986 active site 552526004987 segregation and condensation protein B; Reviewed; Region: scpB; PRK00135 552526004988 segregation and condensation protein A; Reviewed; Region: scpA; PRK00104 552526004989 site-specific tyrosine recombinase XerD-like protein; Reviewed; Region: xerD; PRK02436 552526004990 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 552526004991 DNA binding site [nucleotide binding] 552526004992 active site 552526004993 Int/Topo IB signature motif; other site 552526004994 catalytic residues [active] 552526004995 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_30; cd04643 552526004996 FOG: CBS domain [General function prediction only]; Region: COG0517 552526004997 Escherichia coli YfcE and related proteins, metallophosphatase domain; Region: MPP_YfcE; cd00841 552526004998 active site 552526004999 metal binding site [ion binding]; metal-binding site 552526005000 homotetramer interface [polypeptide binding]; other site 552526005001 putative deoxyribonucleotide triphosphate pyrophosphatase/unknown domain fusion protein; Reviewed; Region: PRK02491 552526005002 NTPase/HAM1. This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515 552526005003 active site 552526005004 dimerization interface [polypeptide binding]; other site 552526005005 glutamate racemase; Provisional; Region: PRK00865 552526005006 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3763 552526005007 Integral membrane protein, interacts with FtsH [General function prediction only]; Region: COG0670 552526005008 Bacterial BAX inhibitor (BI)-1/YccA-like proteins; Region: BI-1-like_bacterial; cd10432 552526005009 Predicted HD superfamily hydrolase [General function prediction only]; Region: COG1418 552526005010 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl17215 552526005011 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 552526005012 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; smart00967 552526005013 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 552526005014 Transposase [DNA replication, recombination, and repair]; Region: COG5421 552526005015 Transposase [DNA replication, recombination, and repair]; Region: COG5421 552526005016 acylphosphatase; Provisional; Region: PRK14434 552526005017 OxaA-like protein precursor; Provisional; Region: PRK02463 552526005018 membrane protein insertase, YidC/Oxa1 family, C-terminal domain; Region: yidC_oxa1_cterm; TIGR03592 552526005019 transcription elongation factor GreA; Reviewed; Region: greA; PRK00226 552526005020 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 552526005021 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 552526005022 Aminodeoxychorismate lyase [Coenzyme transport and metabolism]; Region: COG1559 552526005023 proteins similar to Escherichia coli yceG; Region: yceG_like; cd08010 552526005024 dimerization interface [polypeptide binding]; other site 552526005025 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 552526005026 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 552526005027 Coenzyme A binding pocket [chemical binding]; other site 552526005028 UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421 552526005029 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 552526005030 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 552526005031 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 552526005032 SWIM zinc finger; Region: SWIM; pfam04434 552526005033 Bacterial SNF2 helicase associated; Region: SNF2_assoc; pfam08455 552526005034 SNF2 family N-terminal domain; Region: SNF2_N; pfam00176 552526005035 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 552526005036 ATP binding site [chemical binding]; other site 552526005037 putative Mg++ binding site [ion binding]; other site 552526005038 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 552526005039 nucleotide binding region [chemical binding]; other site 552526005040 ATP-binding site [chemical binding]; other site 552526005041 GTP-binding protein Der; Reviewed; Region: PRK00093 552526005042 EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894 552526005043 G1 box; other site 552526005044 GTP/Mg2+ binding site [chemical binding]; other site 552526005045 Switch I region; other site 552526005046 G2 box; other site 552526005047 Switch II region; other site 552526005048 G3 box; other site 552526005049 G4 box; other site 552526005050 G5 box; other site 552526005051 EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895 552526005052 G1 box; other site 552526005053 GTP/Mg2+ binding site [chemical binding]; other site 552526005054 Switch I region; other site 552526005055 G2 box; other site 552526005056 G3 box; other site 552526005057 Switch II region; other site 552526005058 G4 box; other site 552526005059 G5 box; other site 552526005060 primosomal protein DnaI; Reviewed; Region: PRK08939 552526005061 Primosomal protein DnaI N-terminus; Region: DnaI_N; pfam07319 552526005062 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 552526005063 Walker A motif; other site 552526005064 ATP binding site [chemical binding]; other site 552526005065 Walker B motif; other site 552526005066 Replication initiation/membrane attachment protein [DNA replication, recombination, and repair]; Region: DnaB; COG3611 552526005067 transcriptional regulator NrdR; Validated; Region: nrdR; PRK00464 552526005068 ATP cone domain; Region: ATP-cone; pfam03477 552526005069 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 552526005070 HAMP domain; Region: HAMP; pfam00672 552526005071 dimerization interface [polypeptide binding]; other site 552526005072 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 552526005073 dimer interface [polypeptide binding]; other site 552526005074 phosphorylation site [posttranslational modification] 552526005075 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 552526005076 ATP binding site [chemical binding]; other site 552526005077 Mg2+ binding site [ion binding]; other site 552526005078 G-X-G motif; other site 552526005079 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 552526005080 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 552526005081 active site 552526005082 phosphorylation site [posttranslational modification] 552526005083 intermolecular recognition site; other site 552526005084 dimerization interface [polypeptide binding]; other site 552526005085 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 552526005086 DNA binding site [nucleotide binding] 552526005087 Uncharacterized ACR, COG1399; Region: DUF177; cl00616 552526005088 heat shock protein HtpX; Provisional; Region: PRK04897 552526005089 Uncharacterized conserved protein [Function unknown]; Region: LemA; COG1704 552526005090 Predicted S-adenosylmethionine-dependent methyltransferase involved in bacterial cell division [Cell envelope biogenesis, outer membrane]; Region: GidB; COG0357 552526005091 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 552526005092 S-adenosylmethionine binding site [chemical binding]; other site 552526005093 Trk-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: TrkG; COG0168 552526005094 potassium uptake protein, TrkH family; Region: 2a38; TIGR00933 552526005095 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 552526005096 TrkA-N domain; Region: TrkA_N; pfam02254 552526005097 serine/threonine transporter SstT; Provisional; Region: PRK13628 552526005098 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 552526005099 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 552526005100 dimer interface [polypeptide binding]; other site 552526005101 conserved gate region; other site 552526005102 ABC-ATPase subunit interface; other site 552526005103 ABC-type metal ion transport system, ATPase component [Inorganic ion transport and metabolism]; Region: AbcC; COG1135 552526005104 ATP-binding cassette domain of methionine transporter; Region: ABC_MetN_methionine_transporter; cd03258 552526005105 Walker A/P-loop; other site 552526005106 ATP binding site [chemical binding]; other site 552526005107 Q-loop/lid; other site 552526005108 ABC transporter signature motif; other site 552526005109 Walker B; other site 552526005110 D-loop; other site 552526005111 H-loop/switch region; other site 552526005112 NIL domain; Region: NIL; pfam09383 552526005113 hypothetical protein; Provisional; Region: PRK06446 552526005114 Uncharacterized M20 Dipeptidases; Region: M20_dipept_like_4; cd05681 552526005115 metal binding site [ion binding]; metal-binding site 552526005116 dimer interface [polypeptide binding]; other site 552526005117 ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464 552526005118 NLPA lipoprotein; Region: Lipoprotein_9; pfam03180 552526005119 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 552526005120 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 552526005121 substrate binding pocket [chemical binding]; other site 552526005122 membrane-bound complex binding site; other site 552526005123 hinge residues; other site 552526005124 hypothetical protein; Provisional; Region: PRK12378 552526005125 Helix-Turn-Helix DNA binding domain of the transcription regulators TipAL, Mta, and SkgA; Region: HTH_TipAL-Mta; cd01106 552526005126 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 552526005127 DNA binding residues [nucleotide binding] 552526005128 dimer interface [polypeptide binding]; other site 552526005129 TipAS antibiotic-recognition domain; Region: TipAS; pfam07739 552526005130 hypothetical protein; Provisional; Region: PRK13670 552526005131 HIGH Nucleotidyl Transferase; Region: HIGH_NTase1; cl17673 552526005132 SAM-dependent methyltransferases [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: SmtA; COG0500 552526005133 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 552526005134 S-adenosylmethionine binding site [chemical binding]; other site 552526005135 Uncharacterized homolog of plant Iojap protein [Function unknown]; Region: COG0799 552526005136 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 552526005137 Zn2+ binding site [ion binding]; other site 552526005138 Mg2+ binding site [ion binding]; other site 552526005139 nicotinic acid mononucleotide adenylyltransferase; Provisional; Region: nadD; PRK00071 552526005140 Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165 552526005141 active site 552526005142 (T/H)XGH motif; other site 552526005143 Predicted RNA-binding protein containing KH domain, possibly ribosomal protein [Translation, ribosomal structure and biogenesis]; Region: COG1534 552526005144 GTPase YqeH; Provisional; Region: PRK13796 552526005145 Circularly permuted YqeH GTPase; Region: YqeH; cd01855 552526005146 GTP/Mg2+ binding site [chemical binding]; other site 552526005147 G4 box; other site 552526005148 G5 box; other site 552526005149 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 552526005150 G1 box; other site 552526005151 G1 box; other site 552526005152 GTP/Mg2+ binding site [chemical binding]; other site 552526005153 G2 box; other site 552526005154 Switch I region; other site 552526005155 G2 box; other site 552526005156 Switch I region; other site 552526005157 G3 box; other site 552526005158 G3 box; other site 552526005159 Switch II region; other site 552526005160 Switch II region; other site 552526005161 G4 box; other site 552526005162 Predicted hydrolase of the HAD superfamily [General function prediction only]; Region: COG2179 552526005163 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 552526005164 active site 552526005165 motif I; other site 552526005166 motif II; other site 552526005167 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 552526005168 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 552526005169 Walker A/P-loop; other site 552526005170 ATP binding site [chemical binding]; other site 552526005171 Q-loop/lid; other site 552526005172 ABC transporter signature motif; other site 552526005173 Walker B; other site 552526005174 D-loop; other site 552526005175 H-loop/switch region; other site 552526005176 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 552526005177 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 552526005178 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 552526005179 Walker A/P-loop; other site 552526005180 ATP binding site [chemical binding]; other site 552526005181 Q-loop/lid; other site 552526005182 ABC transporter signature motif; other site 552526005183 Walker B; other site 552526005184 D-loop; other site 552526005185 H-loop/switch region; other site 552526005186 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 552526005187 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 552526005188 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 552526005189 dimer interface [polypeptide binding]; other site 552526005190 conserved gate region; other site 552526005191 putative PBP binding loops; other site 552526005192 ABC-ATPase subunit interface; other site 552526005193 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 552526005194 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 552526005195 dimer interface [polypeptide binding]; other site 552526005196 conserved gate region; other site 552526005197 putative PBP binding loops; other site 552526005198 ABC-ATPase subunit interface; other site 552526005199 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 552526005200 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 552526005201 peptide binding site [polypeptide binding]; other site 552526005202 D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: DacC; COG1686 552526005203 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 552526005204 Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; cl06814 552526005205 D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: DacC; COG1686 552526005206 Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; smart00936 552526005207 D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768 552526005208 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 552526005209 cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814; cl03223 552526005210 FeS assembly protein SufB; Region: sufB; TIGR01980 552526005211 NifU homolog involved in Fe-S cluster formation [Energy production and conversion]; Region: IscU; COG0822 552526005212 Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664 552526005213 trimerization site [polypeptide binding]; other site 552526005214 active site 552526005215 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 552526005216 Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453 552526005217 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 552526005218 catalytic residue [active] 552526005219 Cysteine desulfurase activator SufB [Posttranslational modification, protein turnover, chaperones]; Region: SufB; COG0719 552526005220 FeS assembly protein SufD; Region: sufD; TIGR01981 552526005221 Cysteine desulfurase activator ATPase [Posttranslational modification, protein turnover, chaperones]; Region: sufC; COG0396 552526005222 ABC-type transport system involved in Fe-S cluster assembly, ATPase component; Region: ABC_FeS_Assembly; cd03217 552526005223 Walker A/P-loop; other site 552526005224 ATP binding site [chemical binding]; other site 552526005225 Q-loop/lid; other site 552526005226 ABC transporter signature motif; other site 552526005227 Walker B; other site 552526005228 D-loop; other site 552526005229 H-loop/switch region; other site 552526005230 UDP-N-acetylmuramyl pentapeptide phosphotransferase/UDP-N- acetylglucosamine-1-phosphate transferase [Cell envelope biogenesis, outer membrane]; Region: Rfe; COG0472 552526005231 This subfamily contains Escherichia coli WecA, Bacillus subtilis TagO and related proteins. WecA is an UDP-N-acetylglucosamine (GlcNAc):undecaprenyl-phosphate (Und-P) GlcNAc-1-phosphate transferase that catalyzes the formation of a phosphodiester bond...; Region: GT_WecA_like; cd06853 552526005232 Mg++ binding site [ion binding]; other site 552526005233 putative catalytic motif [active] 552526005234 substrate binding site [chemical binding]; other site 552526005235 adaptor protein; Provisional; Region: PRK02315 552526005236 undecaprenyl pyrophosphate phosphatase; Reviewed; Region: PRK00281 552526005237 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 552526005238 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 552526005239 substrate binding pocket [chemical binding]; other site 552526005240 membrane-bound complex binding site; other site 552526005241 hinge residues; other site 552526005242 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 552526005243 dimer interface [polypeptide binding]; other site 552526005244 conserved gate region; other site 552526005245 putative PBP binding loops; other site 552526005246 ABC-ATPase subunit interface; other site 552526005247 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 552526005248 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 552526005249 Walker A/P-loop; other site 552526005250 ATP binding site [chemical binding]; other site 552526005251 Q-loop/lid; other site 552526005252 ABC transporter signature motif; other site 552526005253 Walker B; other site 552526005254 D-loop; other site 552526005255 H-loop/switch region; other site 552526005256 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 552526005257 A subgroup of the band 7 domain of flotillin (reggie) like proteins. This subgroup contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin. Many of these band 7 domain-containing proteins are lipid raft-associated. Individual...; Region: Band_7_4; cd03407 552526005258 DAK2 domain fusion protein YloV; Region: YloV; TIGR03599 552526005259 DAK2 domain; Region: Dak2; pfam02734 552526005260 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1302 552526005261 50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359 552526005262 fructose-bisphosphate aldolase; Provisional; Region: PRK09197 552526005263 Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947 552526005264 intersubunit interface [polypeptide binding]; other site 552526005265 active site 552526005266 zinc binding site [ion binding]; other site 552526005267 Na+ binding site [ion binding]; other site 552526005268 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 552526005269 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 552526005270 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 552526005271 CTP synthetase; Validated; Region: pyrG; PRK05380 552526005272 CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113 552526005273 Catalytic site [active] 552526005274 active site 552526005275 UTP binding site [chemical binding]; other site 552526005276 Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746 552526005277 active site 552526005278 putative oxyanion hole; other site 552526005279 catalytic triad [active] 552526005280 trigger factor; Provisional; Region: tig; PRK01490 552526005281 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 552526005282 Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698 552526005283 Alpha amylase catalytic domain found in bacterial Alpha-amylases (also called 1,4-alpha-D-glucan-4-glucanohydrolase); Region: AmyAc_bac1_AmyA; cd11315 552526005284 Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366 552526005285 active site 552526005286 Ca binding site [ion binding]; other site 552526005287 catalytic site [active] 552526005288 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 552526005289 Mechanosensitive ion channel; Region: MS_channel; pfam00924 552526005290 hypothetical protein; Provisional; Region: PRK13690 552526005291 ECF-type riboflavin transporter, S component; Region: ECF-ribofla_trS; pfam07155 552526005292 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 552526005293 dimer interface [polypeptide binding]; other site 552526005294 substrate binding site [chemical binding]; other site 552526005295 ATP binding site [chemical binding]; other site 552526005296 tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021 552526005297 Eukaryotic and bacterial pseudouridine synthases similar to E. coli TruA; Region: PseudoU_synth_EcTruA; cd02570 552526005298 dimerization interface 3.5A [polypeptide binding]; other site 552526005299 active site 552526005300 aspartate kinase; Reviewed; Region: PRK09034 552526005301 AAK_AKiii-YclM-BS: Amino Acid Kinase Superfamily (AAK), AKiii-YclM-BS; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the lysine plus threonine-sensitive aspartokinase isoenzyme AKIII, a monofunctional class enzyme found in...; Region: AAK_AKiii-YclM-BS; cd04245 552526005302 putative catalytic residues [active] 552526005303 putative nucleotide binding site [chemical binding]; other site 552526005304 putative aspartate binding site [chemical binding]; other site 552526005305 ACT domains located C-terminal to the catalytic domain of the lysine plus threonine-sensitive aspartokinase isoenzyme AKIII; Region: ACT_AKiii-YclM-BS_1; cd04911 552526005306 allosteric regulatory residue; other site 552526005307 ACT domains located C-terminal to the catalytic domain of the lysine plus threonine-sensitive aspartokinase isoenzyme AKIII; Region: ACT_AKiii-YclM-BS_2; cd04916 552526005308 streptococcal histidine triad protein; Region: strep_his_triad; TIGR01363 552526005309 Streptococcal histidine triad protein; Region: Strep_his_triad; pfam04270 552526005310 Streptococcal histidine triad protein; Region: Strep_his_triad; pfam04270 552526005311 streptococcal histidine triad protein; Region: strep_his_triad; TIGR01363 552526005312 ABC-type metal ion transport system, periplasmic component/surface adhesin [Inorganic ion transport and metabolism]; Region: LraI; COG0803 552526005313 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 552526005314 intersubunit interface [polypeptide binding]; other site 552526005315 DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; pfam13808 552526005316 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 552526005317 DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; cl17880 552526005318 Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase [Lipid metabolism / General function prediction only]; Region: LCB5; COG1597 552526005319 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 552526005320 DNA-binding transcriptional repressor EbgR; Provisional; Region: PRK10339 552526005321 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 552526005322 DNA binding site [nucleotide binding] 552526005323 domain linker motif; other site 552526005324 Ligand-binding domain of DNA transcription repressor GalR which is one of two regulatory proteins involved in galactose transport and metabolism; Region: PBP1_GalR; cd01544 552526005325 putative dimerization interface [polypeptide binding]; other site 552526005326 putative ligand binding site [chemical binding]; other site 552526005327 galactokinase; Provisional; Region: PRK05322 552526005328 Galactokinase galactose-binding signature; Region: GalKase_gal_bdg; pfam10509 552526005329 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 552526005330 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 552526005331 galactose-1-phosphate uridylyltransferase; Provisional; Region: PRK05270 552526005332 Galactose-1-phosphate uridyl transferase, N-terminal domain; Region: GalP_UDP_transf; pfam01087 552526005333 Galactose-1-phosphate uridyl transferase, C-terminal domain; Region: GalP_UDP_tr_C; pfam02744 552526005334 UDP-glucose 4-epimerase [Cell envelope biogenesis, outer membrane]; Region: GalE; COG1087 552526005335 UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247 552526005336 NAD binding site [chemical binding]; other site 552526005337 homodimer interface [polypeptide binding]; other site 552526005338 active site 552526005339 substrate binding site [chemical binding]; other site 552526005340 galactose mutarotase_like; Region: galactose_mutarotase_like; cd09019 552526005341 active site 552526005342 catalytic residues [active] 552526005343 30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132 552526005344 Ribosomal protein L13. Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392 552526005345 23S rRNA interface [nucleotide binding]; other site 552526005346 L3 interface [polypeptide binding]; other site 552526005347 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 552526005348 Helix-turn-helix domain; Region: HTH_38; pfam13936 552526005349 Integrase core domain; Region: rve; pfam00665 552526005350 EDD domain protein, DegV family; Region: DegV; TIGR00762 552526005351 Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645 552526005352 YacP-like NYN domain; Region: NYN_YacP; cl01491 552526005353 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 552526005354 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032 552526005355 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 552526005356 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 552526005357 active site 552526005358 metal binding site [ion binding]; metal-binding site 552526005359 dimerization interface [polypeptide binding]; other site 552526005360 cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260 552526005361 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 552526005362 active site 552526005363 HIGH motif; other site 552526005364 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 552526005365 KMSKS motif; other site 552526005366 Anticodon-binding domain of cysteinyl tRNA synthetases; Region: Anticodon_Ia_Cys; cd07963 552526005367 tRNA binding surface [nucleotide binding]; other site 552526005368 anticodon binding site; other site 552526005369 Serine acetyltransferase [Amino acid transport and metabolism]; Region: CysE; COG1045 552526005370 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354 552526005371 trimer interface [polypeptide binding]; other site 552526005372 active site 552526005373 substrate binding site [chemical binding]; other site 552526005374 CoA binding site [chemical binding]; other site 552526005375 polynucleotide phosphorylase/polyadenylase; Provisional; Region: PRK11824 552526005376 Polyribonucleotide nucleotidyltransferase, repeat 1; Region: RNase_PH_PNPase_1; cd11363 552526005377 RNase E interface [polypeptide binding]; other site 552526005378 trimer interface [polypeptide binding]; other site 552526005379 Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364 552526005380 RNase E interface [polypeptide binding]; other site 552526005381 trimer interface [polypeptide binding]; other site 552526005382 active site 552526005383 Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393 552526005384 S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472 552526005385 RNA binding site [nucleotide binding]; other site 552526005386 Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353 552526005387 16S/18S rRNA binding site [nucleotide binding]; other site 552526005388 S13e-L30e interaction site [polypeptide binding]; other site 552526005389 25S rRNA binding site [nucleotide binding]; other site 552526005390 Fibronectin-binding protein signal sequence; Region: Fb_signal; pfam08341 552526005391 TQXA domain; Region: TQXA_dom; TIGR03934 552526005392 Fibronectin binding repeat; Region: Fn_bind; pfam02986 552526005393 Fibronectin binding repeat; Region: Fn_bind; pfam02986 552526005394 Fibronectin binding repeat; Region: Fn_bind; pfam02986 552526005395 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 552526005396 active site 552526005397 catalytic residues [active] 552526005398 metal binding site [ion binding]; metal-binding site 552526005399 Predicted flavoprotein [General function prediction only]; Region: COG0431 552526005400 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 552526005401 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 552526005402 MarR family; Region: MarR; pfam01047 552526005403 DNA polymerase III PolC; Validated; Region: polC; PRK00448 552526005404 DNA polymerase III polC-type N-terminus; Region: DNA_pol3_alph_N; pfam11490 552526005405 polC_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold nucleic acid binding domain of Bacillus subtilis type C replicative DNA polymerase III alpha subunit (polC). Replication in B. subtilis and Staphylococcus aureus requires two...; Region: polC_OBF; cd04484 552526005406 generic binding surface II; other site 552526005407 generic binding surface I; other site 552526005408 Polymerase and Histidinol Phosphatase domain; Region: PHP; cl17102 552526005409 active site 552526005410 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 552526005411 active site 552526005412 catalytic site [active] 552526005413 substrate binding site [chemical binding]; other site 552526005414 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III at PolC gene; Region: PHP_PolIIIA_POLC; cd07435 552526005415 Bacterial protein of unknown function (DUF925); Region: DUF925; pfam06042 552526005416 prolyl-tRNA synthetase; Provisional; Region: PRK09194 552526005417 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 552526005418 motif 1; other site 552526005419 dimer interface [polypeptide binding]; other site 552526005420 active site 552526005421 motif 2; other site 552526005422 INS is an amino acid-editing domain inserted (INS) into the bacterial class II prolyl-tRNA synthetase (ProRS) however, this CD is not exclusively bacterial. It is also found at the N-terminus of the eukaryotic/archaea-like ProRS's of yeasts and...; Region: ProRS-INS; cd04334 552526005423 putative deacylase active site [active] 552526005424 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 552526005425 active site 552526005426 motif 3; other site 552526005427 ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding; Region: ProRS_anticodon_short; cd00861 552526005428 anticodon binding site; other site 552526005429 RIP metalloprotease RseP; Region: TIGR00054 552526005430 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 552526005431 active site 552526005432 Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020 552526005433 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 552526005434 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 552526005435 putative substrate binding region [chemical binding]; other site 552526005436 CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575 552526005437 Cytidylyltransferase family; Region: CTP_transf_1; pfam01148 552526005438 Undecaprenyl pyrophosphate synthase [Lipid metabolism]; Region: UppS; COG0020 552526005439 Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cd00475 552526005440 catalytic residue [active] 552526005441 putative FPP diphosphate binding site; other site 552526005442 putative FPP binding hydrophobic cleft; other site 552526005443 dimer interface [polypeptide binding]; other site 552526005444 putative IPP diphosphate binding site; other site 552526005445 preprotein translocase subunit YajC; Validated; Region: yajC; PRK06531 552526005446 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 552526005447 catalytic residues [active] 552526005448 alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403 552526005449 Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333 552526005450 Ca binding site [ion binding]; other site 552526005451 active site 552526005452 catalytic site [active] 552526005453 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 552526005454 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 552526005455 Walker A/P-loop; other site 552526005456 ATP binding site [chemical binding]; other site 552526005457 Q-loop/lid; other site 552526005458 ABC transporter signature motif; other site 552526005459 Walker B; other site 552526005460 D-loop; other site 552526005461 H-loop/switch region; other site 552526005462 TOBE domain; Region: TOBE; pfam03459 552526005463 Regulator of polyketide synthase expression [Signal transduction mechanisms / Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2508 552526005464 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 552526005465 Staphylokinase/Streptokinase family; Region: Staphylokinase; pfam02821 552526005466 D-Tyrosyl-tRNAtyr deacylases; a class of tRNA-dependent hydrolases which are capable of hydrolyzing the ester bond of D-Tyrosyl-tRNA reducing the level of cellular D-Tyrosine while recycling the peptidyl-tRNA; found in bacteria and in eukaryotes but not...; Region: Dtyr_deacylase; cd00563 552526005467 putative active site [active] 552526005468 dimerization interface [polypeptide binding]; other site 552526005469 putative tRNAtyr binding site [nucleotide binding]; other site 552526005470 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 552526005471 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 552526005472 Zn2+ binding site [ion binding]; other site 552526005473 Mg2+ binding site [ion binding]; other site 552526005474 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 552526005475 synthetase active site [active] 552526005476 NTP binding site [chemical binding]; other site 552526005477 metal binding site [ion binding]; metal-binding site 552526005478 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 552526005479 ACT domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876 552526005480 Gram positive anchor; Region: Gram_pos_anchor; pfam00746 552526005481 YSIRK-targeted surface antigen transcriptional regulator; Region: adjacent_YSIRK; TIGR04094 552526005482 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 552526005483 flavoprotein NrdI; Provisional; Region: PRK02551 552526005484 Streptococcus agalactiae RgfB, part of a putative two component signal transduction system, and related proteins; Region: RgfB-like; cd09079 552526005485 putative catalytic site [active] 552526005486 putative metal binding site [ion binding]; other site 552526005487 putative phosphate binding site [ion binding]; other site 552526005488 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 552526005489 PTS system, IIBC component; Region: PTS-II-BC-unk1; TIGR02003 552526005490 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 552526005491 active site turn [active] 552526005492 phosphorylation site [posttranslational modification] 552526005493 Phosphotransferase system IIA components [Carbohydrate transport and metabolism]; Region: NagE; COG2190 552526005494 HPr interaction site; other site 552526005495 glycerol kinase (GK) interaction site [polypeptide binding]; other site 552526005496 active site 552526005497 phosphorylation site [posttranslational modification] 552526005498 Transcriptional regulators [Transcription]; Region: PurR; COG1609 552526005499 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 552526005500 DNA binding site [nucleotide binding] 552526005501 domain linker motif; other site 552526005502 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 552526005503 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 552526005504 dimerization interface [polypeptide binding]; other site 552526005505 putative DNA binding site [nucleotide binding]; other site 552526005506 putative Zn2+ binding site [ion binding]; other site 552526005507 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1385 552526005508 RNA methyltransferase, RsmE family; Region: TIGR00046 552526005509 Ribosomal protein L11 methyltransferase (PrmA); Region: PrmA; pfam06325 552526005510 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 552526005511 S-adenosylmethionine binding site [chemical binding]; other site 552526005512 Streptococcal histidine triad protein; Region: Strep_his_triad; pfam04270 552526005513 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_23; cd04682 552526005514 nudix motif; other site 552526005515 ASC-1 homology domain, subfamily similar to Pyrococcus furiosus Pf0470. The ASCH domain, a small beta-barrel domain found in all three kingdoms of life, resembles the RNA-binding PUA domain and may also interact with RNA. ASCH has been proposed to...; Region: ASCH_PF0470_like; cd06555 552526005516 Protein of unknown function (DUF3013); Region: DUF3013; pfam11217 552526005517 aminodeoxychorismate synthase; Provisional; Region: PRK07508 552526005518 chorismate binding enzyme; Region: Chorismate_bind; cl10555 552526005519 PyridoxaL 5'-Phosphate Dependent Enzymes class IV (PLPDE_IV). This D-amino acid superfamily, one of five classes of PLPDE, consists of branched-chain amino acid aminotransferases (BCAT), D-amino acid transferases (DAAT), and...; Region: PLPDE_IV; cl00224 552526005520 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 552526005521 substrate-cofactor binding pocket; other site 552526005522 pyridoxal 5'-phosphate binding site [chemical binding]; other site 552526005523 catalytic residue [active] 552526005524 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 552526005525 Glutamine amidotransferase class-I; Region: GATase; pfam00117 552526005526 glutamine binding [chemical binding]; other site 552526005527 catalytic triad [active] 552526005528 recombination factor protein RarA; Reviewed; Region: PRK13342 552526005529 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 552526005530 Walker A motif; other site 552526005531 ATP binding site [chemical binding]; other site 552526005532 Walker B motif; other site 552526005533 arginine finger; other site 552526005534 MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002 552526005535 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 552526005536 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 552526005537 non-specific DNA binding site [nucleotide binding]; other site 552526005538 salt bridge; other site 552526005539 sequence-specific DNA binding site [nucleotide binding]; other site 552526005540 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 552526005541 non-specific DNA binding site [nucleotide binding]; other site 552526005542 salt bridge; other site 552526005543 sequence-specific DNA binding site [nucleotide binding]; other site 552526005544 transcriptional activator, Rgg/GadR/MutR family, C-terminal domain; Region: RGG_Cterm; TIGR01716 552526005545 H+ Antiporter protein; Region: 2A0121; TIGR00900 552526005546 topology modulation protein; Provisional; Region: PRK07261 552526005547 AAA domain; Region: AAA_17; pfam13207 552526005548 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 552526005549 Collagen triple helix repeat (20 copies); Region: Collagen; pfam01391 552526005550 Gram positive anchor; Region: Gram_pos_anchor; pfam00746 552526005551 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 552526005552 catalytic core [active] 552526005553 Microcin C7 self-immunity protein determines resistance to exogenous microcin C7; Region: Peptidase_S66_mccF_like; cd07062 552526005554 putative dimer interface [polypeptide binding]; other site 552526005555 catalytic triad [active] 552526005556 Glycerol dehydrogenase and related enzymes [Energy production and conversion]; Region: GldA; COG0371 552526005557 Glycerol dehydrogenases (GlyDH) catalyzes oxidation of glycerol to dihydroxyacetone in glycerol dissmilation; Region: GlyDH; cd08170 552526005558 dimer interface [polypeptide binding]; other site 552526005559 active site 552526005560 metal binding site [ion binding]; metal-binding site 552526005561 Transaldolase-like fructose-6-phosphate aldolases (FSA) found in bacteria and archaea; Region: Transaldolase_FSA; cd00956 552526005562 active site 552526005563 intersubunit interactions; other site 552526005564 catalytic residue [active] 552526005565 Pyruvate-formate lyase [Energy production and conversion]; Region: PflD; COG1882 552526005566 Pyruvate formate lyase 2 and related enzymes; Region: PFL2_DhaB_BssA; cd01677 552526005567 dimer interface [polypeptide binding]; other site 552526005568 active site 552526005569 glycine loop; other site 552526005570 Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455 552526005571 cellobiose phosphotransferase system IIC component; Reviewed; Region: celD; PRK09592 552526005572 PTS_IIB_chitobiose_lichenan: subunit IIB of enzyme II (EII) of the N,N-diacetylchitobiose-specific and lichenan-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In these systems, EII is either a lichenan- or an N; Region: PTS_IIB_chitobiose_lichenan; cd05564 552526005573 active site 552526005574 P-loop; other site 552526005575 phosphorylation site [posttranslational modification] 552526005576 PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_lac; cd00215 552526005577 active site 552526005578 methionine cluster; other site 552526005579 phosphorylation site [posttranslational modification] 552526005580 metal binding site [ion binding]; metal-binding site 552526005581 Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription]; Region: DeoR; COG2390 552526005582 Homeodomain-like domain; Region: HTH_23; pfam13384 552526005583 Putative sugar-binding domain; Region: Sugar-bind; pfam04198 552526005584 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 552526005585 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 552526005586 DNA-binding site [nucleotide binding]; DNA binding site 552526005587 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 552526005588 glycyl-radical enzyme activating protein family; Region: PFLE_PFLC; TIGR02494 552526005589 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 552526005590 FeS/SAM binding site; other site 552526005591 Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788 552526005592 Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108 552526005593 GDP-binding site [chemical binding]; other site 552526005594 ACT binding site; other site 552526005595 IMP binding site; other site 552526005596 Uncharacterized protein involved in tellurite resistance [Inorganic ion transport and metabolism]; Region: TelA; COG3853 552526005597 Sortase C (SrtC) or subfamily-3 sortases are membrane cysteine transpeptidases found in Gram-positive bacteria that anchor surface proteins to peptidoglycans of the bacterial cell wall envelope. This involves a transpeptidation reaction in which the...; Region: Sortase_C_3; cd05827 552526005598 active site 552526005599 catalytic site [active] 552526005600 fimbrial isopeptide formation D2 domain; Region: RrgB_K2N_iso_D2; TIGR04226 552526005601 Cna protein B-type domain; Region: Cna_B; pfam05738 552526005602 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 552526005603 metal ion-dependent adhesion site (MIDAS); other site 552526005604 Cna protein B-type domain; Region: Cna_B; pfam05738 552526005605 M protein trans-acting positive regulator (MGA) HTH domain; Region: HTH_Mga; pfam08280 552526005606 Mga helix-turn-helix domain; Region: Mga; pfam05043 552526005607 M protein trans-acting positive regulator (MGA) PRD domain; Region: PRD_Mga; pfam08270 552526005608 Cna protein B-type domain; Region: Cna_B; pfam05738 552526005609 C-terminus of bacterial fibrinogen-binding adhesin; Region: SdrG_C_C; pfam10425 552526005610 Cna protein B-type domain; Region: Cna_B; pfam05738 552526005611 Sortase C (SrtC) or subfamily-3 sortases are membrane cysteine transpeptidases found in Gram-positive bacteria that anchor surface proteins to peptidoglycans of the bacterial cell wall envelope. This involves a transpeptidation reaction in which the...; Region: Sortase_C_3; cd05827 552526005612 active site 552526005613 catalytic site [active] 552526005614 Sortase C (SrtC) or subfamily-3 sortases are membrane cysteine transpeptidases found in Gram-positive bacteria that anchor surface proteins to peptidoglycans of the bacterial cell wall envelope. This involves a transpeptidation reaction in which the...; Region: Sortase_C_3; cd05827 552526005615 active site 552526005616 catalytic site [active] 552526005617 Cna protein B-type domain; Region: Cna_B; pfam05738 552526005618 LPXTG-motif cell wall anchor domain; Region: LPXTG_anchor; TIGR01167 552526005619 fimbrial isopeptide formation D2 domain; Region: RrgB_K2N_iso_D2; TIGR04226 552526005620 YSIRK-targeted surface antigen transcriptional regulator; Region: adjacent_YSIRK; TIGR04094 552526005621 Hsp33-like chaperonin; Reviewed; Region: hslO; PRK00114 552526005622 Heat shock protein 33 (Hsp33): Cytosolic protein that acts as a molecular chaperone under oxidative conditions. In normal (reducing) cytosolic conditions, four conserved Cys residues are coordinated by a Zn ion. Under oxidative stress (such as heat...; Region: Hsp33; cd00498 552526005623 dimerization interface [polypeptide binding]; other site 552526005624 domain crossover interface; other site 552526005625 redox-dependent activation switch; other site 552526005626 putative TIM-barrel protein, nifR3 family; Region: nifR3_yhdG; TIGR00737 552526005627 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 552526005628 FMN binding site [chemical binding]; other site 552526005629 active site 552526005630 catalytic residues [active] 552526005631 substrate binding site [chemical binding]; other site 552526005632 Deoxynucleoside kinases [Nucleotide transport and metabolism]; Region: COG1428 552526005633 Deoxyribonucleoside kinase (dNK) catalyzes the phosphorylation of deoxyribonucleosides to yield corresponding monophosphates (dNMPs). This family consists of various deoxynucleoside kinases including deoxyribo- cytidine (EC 2.7.1.74), guanosine (EC 2.7.1; Region: dNK; cd01673 552526005634 Substrate-binding site [chemical binding]; other site 552526005635 Substrate specificity [chemical binding]; other site 552526005636 ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: PhnK; COG1101 552526005637 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 552526005638 Walker A/P-loop; other site 552526005639 ATP binding site [chemical binding]; other site 552526005640 Q-loop/lid; other site 552526005641 ABC transporter signature motif; other site 552526005642 Walker B; other site 552526005643 D-loop; other site 552526005644 H-loop/switch region; other site 552526005645 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 552526005646 Transmembrane subunit (TM) of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which are involved in the uptake of branched-chain amino acids (AAs), as well as TMs of transporters involved in the uptake of...; Region: TM_PBP1_branched-chain-AA_like; cd06574 552526005647 TM-ABC transporter signature motif; other site 552526005648 Type I periplasmic ligand-binding domain of uncharacterized ABC-type transport systems that are predicted to be involved in the uptake of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_uncharacterized_transporter; cd06325 552526005649 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 552526005650 zinc binding site [ion binding]; other site 552526005651 putative ligand binding site [chemical binding]; other site 552526005652 Type I periplasmic ligand-binding domain of uncharacterized ABC-type transport systems that are predicted to be involved in the uptake of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_uncharacterized_transporter; cd06325 552526005653 zinc binding site [ion binding]; other site 552526005654 putative ligand binding site [chemical binding]; other site 552526005655 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 552526005656 Helix-turn-helix domain; Region: HTH_38; pfam13936 552526005657 Integrase core domain; Region: rve; pfam00665 552526005658 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 552526005659 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 552526005660 dimer interface [polypeptide binding]; other site 552526005661 ssDNA binding site [nucleotide binding]; other site 552526005662 tetramer (dimer of dimers) interface [polypeptide binding]; other site 552526005663 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 552526005664 S-adenosylmethionine binding site [chemical binding]; other site 552526005665 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 552526005666 putative tRNA-binding site [nucleotide binding]; other site 552526005667 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 552526005668 catalytic residues [active] 552526005669 Cellulase M and related proteins [Carbohydrate transport and metabolism]; Region: FrvX; COG1363 552526005670 glutamyl aminopeptidase; Region: glu_aminopep; TIGR03107 552526005671 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232 552526005672 pyrroline-5-carboxylate reductase; Reviewed; Region: PRK11880 552526005673 CAAX protease self-immunity; Region: Abi; pfam02517 552526005674 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 552526005675 non-specific DNA binding site [nucleotide binding]; other site 552526005676 salt bridge; other site 552526005677 sequence-specific DNA binding site [nucleotide binding]; other site 552526005678 hypothetical protein; Validated; Region: PRK02101 552526005679 4Fe-4S single cluster domain; Region: Fer4_12; pfam13353 552526005680 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 552526005681 FeS/SAM binding site; other site 552526005682 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 552526005683 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 552526005684 Coenzyme A binding pocket [chemical binding]; other site 552526005685 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 552526005686 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 552526005687 anaerobic ribonucleoside triphosphate reductase; Provisional; Region: PRK09263 552526005688 ATP cone domain; Region: ATP-cone; pfam03477 552526005689 Class III ribonucleotide reductase; Region: RNR_III; cd01675 552526005690 effector binding site; other site 552526005691 active site 552526005692 Zn binding site [ion binding]; other site 552526005693 glycine loop; other site 552526005694 Predicted membrane protein (DUF2079); Region: DUF2079; pfam09852 552526005695 hypothetical protein; Provisional; Region: PRK13678 552526005696 Holliday junction resolvase-like protein; Reviewed; Region: PRK00109 552526005697 hypothetical protein; Provisional; Region: PRK05473 552526005698 Arsenate Reductase (ArsC) family, Spx subfamily; Spx is a unique RNA polymerase (RNAP)-binding protein present in bacilli and some mollicutes. It inhibits transcription by binding to the C-terminal domain of the alpha subunit of RNAP, disrupting complex...; Region: ArsC_Spx; cd03032 552526005699 ArsC family; Region: ArsC; pfam03960 552526005700 putative catalytic residues [active] 552526005701 thiol/disulfide switch; other site 552526005702 Integrase core domain; Region: rve; pfam00665 552526005703 Integrase core domain; Region: rve_2; pfam13333 552526005704 HTH-like domain; Region: HTH_21; pfam13276 552526005705 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 552526005706 Helix-turn-helix domain; Region: HTH_28; pfam13518 552526005707 Helix-turn-helix domain; Region: HTH_28; pfam13518 552526005708 Winged helix-turn helix; Region: HTH_29; pfam13551 552526005709 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 552526005710 Helix-turn-helix domain; Region: HTH_28; pfam13518 552526005711 putative transposase OrfB; Reviewed; Region: PHA02517 552526005712 HTH-like domain; Region: HTH_21; pfam13276 552526005713 Integrase core domain; Region: rve; pfam00665 552526005714 Integrase core domain; Region: rve_2; pfam13333 552526005715 recombinase A; Provisional; Region: recA; PRK09354 552526005716 RecA is a bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response. RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983 552526005717 hexamer interface [polypeptide binding]; other site 552526005718 Walker A motif; other site 552526005719 ATP binding site [chemical binding]; other site 552526005720 Walker B motif; other site 552526005721 competence damage-inducible protein A; Provisional; Region: PRK00549 552526005722 Competence-damaged protein. CinA is the first gene in the competence- inducible (cin) operon and is thought to be specifically required at some stage in the process of transformation. This domain is closely related to a domain, found in a variety of...; Region: cinA; cd00885 552526005723 putative MPT binding site; other site 552526005724 Uncharacterized protein (competence- and mitomycin-induced) [General function prediction only]; Region: CinA; COG1546 552526005725 PLA2_like: Phospholipase A2, a super-family of secretory and cytosolic enzymes; the latter are either Ca dependent or Ca independent. PLA2 cleaves the sn-2 position of the glycerol backbone of phospholipids (PC or phosphatidylethanolamine), usually in a...; Region: PLA2_like; cl05417 552526005726 primary metal binding site; other site 552526005727 catalytic residues [active] 552526005728 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 552526005729 Helix-turn-helix domain; Region: HTH_38; pfam13936 552526005730 Integrase core domain; Region: rve; pfam00665 552526005731 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 552526005732 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 552526005733 non-specific DNA binding site [nucleotide binding]; other site 552526005734 salt bridge; other site 552526005735 sequence-specific DNA binding site [nucleotide binding]; other site 552526005736 Methyladenine glycosylase; Region: Adenine_glyco; pfam03352 552526005737 Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116 552526005738 RuvA N terminal domain; Region: RuvA_N; pfam01330 552526005739 RuvA, C-terminal domain; Region: RuvA_C; pfam07499 552526005740 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 552526005741 Major Facilitator Superfamily; Region: MFS_1; pfam07690 552526005742 putative substrate translocation pore; other site 552526005743 DNA mismatch repair protein; Reviewed; Region: mutL; PRK00095 552526005744 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 552526005745 ATP binding site [chemical binding]; other site 552526005746 Mg2+ binding site [ion binding]; other site 552526005747 G-X-G motif; other site 552526005748 MutL_Trans: transducer domain, having a ribosomal S5 domain 2-like fold, conserved in the C-terminal domain of DNA mismatch repair (MutL/MLH1/PMS2) family. This transducer domain is homologous to the second domain of the DNA gyrase B subunit, which is...; Region: MutL_Trans; cd00782 552526005749 ATP binding site [chemical binding]; other site 552526005750 MutL C terminal dimerisation domain; Region: MutL_C; pfam08676 552526005751 DNA mismatch repair protein MutS; Provisional; Region: PRK05399 552526005752 MutS domain I; Region: MutS_I; pfam01624 552526005753 MutS domain II; Region: MutS_II; pfam05188 552526005754 MutS domain III; Region: MutS_III; pfam05192 552526005755 MutS domain V; Region: MutS_V; pfam00488 552526005756 Walker A/P-loop; other site 552526005757 ATP binding site [chemical binding]; other site 552526005758 Q-loop/lid; other site 552526005759 ABC transporter signature motif; other site 552526005760 Walker B; other site 552526005761 D-loop; other site 552526005762 H-loop/switch region; other site 552526005763 Protein of unknown function (DUF964); Region: DUF964; cl01483 552526005764 Arginine repressor, DNA binding domain; Region: Arg_repressor; pfam01316 552526005765 arginine repressor; Region: argR_whole; TIGR01529 552526005766 Arginine repressor, C-terminal domain; Region: Arg_repressor_C; pfam02863 552526005767 ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: COG4619 552526005768 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 552526005769 ABC transporter; Region: ABC_tran_2; pfam12848 552526005770 ABC-type molybdenum transport system, ATPase component/photorepair protein PhrA [Inorganic ion transport and metabolism]; Region: ModF; COG1119 552526005771 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 552526005772 Uncharacterized conserved protein [Function unknown]; Region: COG1284 552526005773 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 552526005774 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 552526005775 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 552526005776 Uncharacterized conserved protein [Function unknown]; Region: COG1284 552526005777 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 552526005778 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 552526005779 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 552526005780 Uncharacterized conserved protein [Function unknown]; Region: COG1284 552526005781 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 552526005782 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 552526005783 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 552526005784 aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476 552526005785 EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317 552526005786 dimer interface [polypeptide binding]; other site 552526005787 anticodon binding site; other site 552526005788 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777 552526005789 homodimer interface [polypeptide binding]; other site 552526005790 motif 1; other site 552526005791 active site 552526005792 motif 2; other site 552526005793 GAD domain; Region: GAD; pfam02938 552526005794 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 552526005795 active site 552526005796 motif 3; other site 552526005797 histidyl-tRNA synthetase; Reviewed; Region: hisS; PRK00037 552526005798 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 552526005799 dimer interface [polypeptide binding]; other site 552526005800 motif 1; other site 552526005801 active site 552526005802 motif 2; other site 552526005803 HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859 552526005804 anticodon binding site; other site 552526005805 50S ribosomal protein L32; Validated; Region: rpmF; PRK01110 552526005806 50S ribosomal protein L33; Validated; Region: rpmG; PRK00595 552526005807 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 552526005808 Transposase; Region: DDE_Tnp_ISL3; pfam01610 552526005809 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 552526005810 non-specific DNA binding site [nucleotide binding]; other site 552526005811 salt bridge; other site 552526005812 sequence-specific DNA binding site [nucleotide binding]; other site 552526005813 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 552526005814 binding surface 552526005815 TPR motif; other site 552526005816 H+ Antiporter protein; Region: 2A0121; TIGR00900 552526005817 Dinucleotide-utilizing enzymes involved in molybdopterin and thiamine biosynthesis family 2 [Coenzyme metabolism]; Region: ThiF; COG0476 552526005818 ThiF family; Region: ThiF; pfam00899 552526005819 ATP binding site [chemical binding]; other site 552526005820 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 552526005821 104 kDa microneme/rhoptry antigen; Provisional; Region: PTZ00449 552526005822 protein binding site [polypeptide binding]; other site 552526005823 Domain present in PSD-95, Dlg, and ZO-1/2; Region: PDZ; smart00228 552526005824 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 552526005825 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 552526005826 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 552526005827 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 552526005828 active site 552526005829 phosphorylation site [posttranslational modification] 552526005830 intermolecular recognition site; other site 552526005831 dimerization interface [polypeptide binding]; other site 552526005832 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 552526005833 DNA binding residues [nucleotide binding] 552526005834 dimerization interface [polypeptide binding]; other site 552526005835 Pseudomonas avirulence D protein (AvrD); Region: AvrD; pfam05655 552526005836 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 552526005837 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 552526005838 Walker A/P-loop; other site 552526005839 ATP binding site [chemical binding]; other site 552526005840 Q-loop/lid; other site 552526005841 ABC transporter signature motif; other site 552526005842 Walker B; other site 552526005843 D-loop; other site 552526005844 H-loop/switch region; other site 552526005845 ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]; Region: LolE; COG4591 552526005846 FtsX-like permease family; Region: FtsX; pfam02687 552526005847 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 552526005848 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 552526005849 FtsX-like permease family; Region: FtsX; pfam02687 552526005850 Predicted membrane protein [Function unknown]; Region: COG2035 552526005851 Coenzyme A pyrophosphatase (CoAse), a member of the Nudix hydrolase superfamily, functions to catalyze the elimination of oxidized inactive CoA, which can inhibit CoA-utilizing enzymes. The need of CoAses mainly arises under conditions of oxidative...; Region: CoAse; cd03426 552526005852 putative active site [active] 552526005853 putative CoA binding site [chemical binding]; other site 552526005854 nudix motif; other site 552526005855 metal binding site [ion binding]; metal-binding site 552526005856 Predicted transcriptional regulators [Transcription]; Region: COG1695 552526005857 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 552526005858 Predicted membrane protein [Function unknown]; Region: COG4709 552526005859 Predicted membrane protein [Function unknown]; Region: COG4709 552526005860 Domain of unknown function (DUF4097); Region: DUF4097; pfam13349 552526005861 Domain of unknown function (DUF4098); Region: DUF4098; pfam13345 552526005862 Domain of unknown function (DUF4098); Region: DUF4098; pfam13345 552526005863 Predicted membrane protein [Function unknown]; Region: COG1511 552526005864 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061 552526005865 YhgE/Pip C-terminal domain; Region: pip_yhgE_Cterm; TIGR03062 552526005866 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 552526005867 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 552526005868 Plasmid stabilisation system protein; Region: Plasmid_stabil; pfam05016 552526005869 RelB antitoxin; Region: RelB; cl01171 552526005870 Protein of unknown function (DUF1492); Region: DUF1492; pfam07374 552526005871 30S ribosomal protein S4; Validated; Region: rpsD; PRK05327 552526005872 Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163 552526005873 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 552526005874 RNA binding surface [nucleotide binding]; other site 552526005875 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 552526005876 Transposase; Region: DDE_Tnp_ISL3; pfam01610 552526005877 Uncharacterized protein conserved in bacteria [Function unknown]; Region: Veg; COG4466 552526005878 replicative DNA helicase; Provisional; Region: PRK05748 552526005879 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 552526005880 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 552526005881 Walker A motif; other site 552526005882 ATP binding site [chemical binding]; other site 552526005883 Walker B motif; other site 552526005884 DNA binding loops [nucleotide binding] 552526005885 50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137 552526005886 Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281 552526005887 Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948 552526005888 Predicted signaling protein consisting of a modified GGDEF domain and a DHH domain [Signal transduction mechanisms]; Region: COG3887 552526005889 DHH family; Region: DHH; pfam01368 552526005890 DHHA1 domain; Region: DHHA1; pfam02272 552526005891 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 552526005892 nudix motif; other site 552526005893 Predicted tRNA(5-methylaminomethyl-2-thiouridylate) methyltransferase, contains the PP-loop ATPase domain [Translation, ribosomal structure and biogenesis]; Region: TrmU; COG0482 552526005894 tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998 552526005895 L-serine dehydratase, iron-sulfur-dependent, beta subunit; Region: sda_beta; TIGR00719 552526005896 Serine dehydratase beta chain; Region: SDH_beta; pfam03315 552526005897 C-terminal ACT domain of the L-serine dehydratase (LSD), iron-sulfur-dependent, beta subunit; Region: ACT_LSD; cd04903 552526005898 putative L-serine binding site [chemical binding]; other site 552526005899 Serine dehydratase alpha chain; Region: SDH_alpha; cl12120 552526005900 L-serine deaminase [Amino acid transport and metabolism]; Region: SdaA; COG1760 552526005901 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 552526005902 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 552526005903 motif II; other site 552526005904 ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619 552526005905 cobalt transporter ATP-binding subunit; Provisional; Region: cbiO; PRK13649 552526005906 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 552526005907 Walker A/P-loop; other site 552526005908 ATP binding site [chemical binding]; other site 552526005909 Q-loop/lid; other site 552526005910 ABC transporter signature motif; other site 552526005911 Walker B; other site 552526005912 D-loop; other site 552526005913 H-loop/switch region; other site 552526005914 cobalt transporter ATP-binding subunit; Provisional; Region: cbiO; PRK13650 552526005915 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 552526005916 Walker A/P-loop; other site 552526005917 ATP binding site [chemical binding]; other site 552526005918 Q-loop/lid; other site 552526005919 ABC transporter signature motif; other site 552526005920 Walker B; other site 552526005921 D-loop; other site 552526005922 H-loop/switch region; other site 552526005923 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453 552526005924 Helix-turn-helix domain; Region: HTH_25; pfam13413 552526005925 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 552526005926 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 552526005927 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 552526005928 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 552526005929 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 552526005930 S4 domain; Region: S4_2; pfam13275 552526005931 recombination protein F; Reviewed; Region: recF; PRK00064 552526005932 ATP-binding cassette domain of RecF; Region: ABC_RecF; cd03242 552526005933 Walker A/P-loop; other site 552526005934 ATP binding site [chemical binding]; other site 552526005935 Q-loop/lid; other site 552526005936 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 552526005937 ABC transporter signature motif; other site 552526005938 Walker B; other site 552526005939 D-loop; other site 552526005940 H-loop/switch region; other site 552526005941 Putative glucose uptake permease [Carbohydrate transport and metabolism]; Region: GlcU; COG4975 552526005942 Protein of unknown function (DUF2974); Region: DUF2974; pfam11187 552526005943 Protein of unknown function (DUF1310); Region: DUF1310; pfam07006 552526005944 Protein of unknown function (DUF1310); Region: DUF1310; pfam07006 552526005945 Protein of unknown function (DUF1310); Region: DUF1310; pfam07006 552526005946 inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567 552526005947 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 552526005948 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein. IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a...; Region: CBS_pair_IMPDH; cd04601 552526005949 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 552526005950 active site 552526005951 tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282 552526005952 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 552526005953 active site 552526005954 HIGH motif; other site 552526005955 dimer interface [polypeptide binding]; other site 552526005956 KMSKS motif; other site 552526005957 Uncharacterized conserved protein [Function unknown]; Region: COG1284 552526005958 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 552526005959 Uncharacterized conserved protein [Function unknown]; Region: COG1284 552526005960 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 552526005961 ABC transporter ATP-binding protein; Provisional; Region: PRK15064 552526005962 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 552526005963 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 552526005964 ABC transporter; Region: ABC_tran_2; pfam12848 552526005965 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 552526005966 Predicted membrane protein [Function unknown]; Region: COG4485 552526005967 rRNA large subunit methyltransferase; Provisional; Region: PRK00103 552526005968 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 552526005969 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 552526005970 protein binding site [polypeptide binding]; other site 552526005971 ParB-like nuclease domain; Region: ParBc; pfam02195 552526005972 KorB domain; Region: KorB; pfam08535