-- dump date 20140620_082004 -- class Genbank::misc_feature -- table misc_feature_note -- id note 40041000001 chromosomal replication initiation protein; Reviewed; Region: dnaA; PRK00149 40041000002 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 40041000003 Walker A motif; other site 40041000004 ATP binding site [chemical binding]; other site 40041000005 Walker B motif; other site 40041000006 arginine finger; other site 40041000007 C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571 40041000008 DnaA box-binding interface [nucleotide binding]; other site 40041000009 HMMPfam hit to PF00308, Chromosomal replication initiator, DnaA, score 7.8e-117 40041000010 PS00017 ATP/GTP-binding site motif A (P-loop). 40041000011 HMMPfam hit to PF08299, Chromosomal replication initiator, DnaA C-terminal, score 7.7e-36 40041000012 PS01008 DnaA protein signature. 40041000013 DNA polymerase III subunit beta; Validated; Region: PRK05643 40041000014 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140 40041000015 putative DNA binding surface [nucleotide binding]; other site 40041000016 dimer interface [polypeptide binding]; other site 40041000017 beta-clamp/clamp loader binding surface; other site 40041000018 beta-clamp/translesion DNA polymerase binding surface; other site 40041000019 HMMPfam hit to PF00712, DNA polymerase III, beta chain, score 2.6e-24 40041000020 HMMPfam hit to PF02767, DNA polymerase III, beta chain, score 4.9e-34 40041000021 HMMPfam hit to PF02768, DNA polymerase III, beta chain, score 2.1e-31 40041000022 Bacterial protein of unknown function (DUF951); Region: DUF951; pfam06107 40041000023 HMMPfam hit to PF06107, Protein of unknown function DUF951, bacterial, score 1.6e-44 40041000024 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 40041000025 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 40041000026 non-specific DNA binding site [nucleotide binding]; other site 40041000027 salt bridge; other site 40041000028 sequence-specific DNA binding site [nucleotide binding]; other site 40041000029 HMMPfam hit to PF01381, Helix-turn-helix type 3, score 2.8e-18 40041000030 Predicted helix-turn-helix motif with score 2169.000, SD 6.57 at aa 17-38, sequence LSQDALAEKLFISRQAISKWEN 40041000031 1 probable transmembrane helix predicted for SZO00040 by TMHMM2.0 at aa 97-119 40041000032 GTP-binding protein YchF; Reviewed; Region: PRK09601 40041000033 YchF GTPase; Region: YchF; cd01900 40041000034 G1 box; other site 40041000035 GTP/Mg2+ binding site [chemical binding]; other site 40041000036 Switch I region; other site 40041000037 G2 box; other site 40041000038 Switch II region; other site 40041000039 G3 box; other site 40041000040 G4 box; other site 40041000041 G5 box; other site 40041000042 TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867 40041000043 HMMPfam hit to PF01926, GTP-binding protein, HSR1-related, score 1.8e-34 40041000044 PS00017 ATP/GTP-binding site motif A (P-loop). 40041000045 HMMPfam hit to PF06071, Protein of unknown function DUF933, score 3e-61 40041000046 Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462 40041000047 putative active site [active] 40041000048 catalytic residue [active] 40041000049 HMMPfam hit to PF01195, Peptidyl-tRNA hydrolase, score 1e-82 40041000050 PS01196 Peptidyl-tRNA hydrolase signature 2. 40041000051 Transcription-repair coupling factor (superfamily II helicase) [DNA replication, recombination, and repair / Transcription]; Region: Mfd; COG1197 40041000052 CarD-like/TRCF domain; Region: CarD_TRCF; smart01058 40041000053 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 40041000054 ATP binding site [chemical binding]; other site 40041000055 putative Mg++ binding site [ion binding]; other site 40041000056 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 40041000057 nucleotide binding region [chemical binding]; other site 40041000058 ATP-binding site [chemical binding]; other site 40041000059 This domain is found in proteins necessary for strand-specific repair in DNA such as TRCF in Escherichia coli; Region: TRCF; smart00982 40041000060 HMMPfam hit to PF02559, Transcription factor CarD, score 5.3e-51 40041000061 HMMPfam hit to PF00270, DNA/RNA helicase, DEAD/DEAH box type, N-terminal, score 8.7e-42 40041000062 PS00017 ATP/GTP-binding site motif A (P-loop). 40041000063 HMMPfam hit to PF00271, DNA/RNA helicase, C-terminal, score 6.1e-20 40041000064 HMMPfam hit to PF03461, TRCF, score 6.2e-35 40041000065 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 40041000066 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 40041000067 HMMPfam hit to PF01943, Polysaccharide biosynthesis protein, score 8e-06 40041000068 14 probable transmembrane helices predicted for SZO00080 by TMHMM2.0 at aa 17-37, 52-74, 81-103, 118-140, 159-181, 185-202, 223-245, 281-303, 315-337, 347-369, 382-404, 409-426, 433-455 and 460-482 40041000069 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 40041000070 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 40041000071 RNA binding surface [nucleotide binding]; other site 40041000072 HMMPfam hit to PF01479, RNA-binding S4, score 2.3e-10 40041000073 Septum formation initiator [Cell division and chromosome partitioning]; Region: COG2919 40041000074 Septum formation initiator; Region: DivIC; pfam04977 40041000075 1 probable transmembrane helix predicted for SZO00100 by TMHMM2.0 at aa 37-54 40041000076 HMMPfam hit to PF04977, Septum formation initiator, score 2.3e-21 40041000077 Beta-lactamase class A [Defense mechanisms]; Region: PenP; COG2367 40041000078 SH3-like domain; Region: SH3_8; pfam13457 40041000079 Beta-lactamase enzyme family; Region: Beta-lactamase2; pfam13354 40041000080 PS00017 ATP/GTP-binding site motif A (P-loop). 40041000081 tRNA(Ile)-lysidine synthase MesJ [Cell cycle control, cell division, chromosome partitioning]; Region: MesJ; COG0037 40041000082 N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992 40041000083 Ligand Binding Site [chemical binding]; other site 40041000084 TilS substrate C-terminal domain; Region: TilS_C; smart00977 40041000085 HMMPfam hit to PF01171, PP-loop, score 1.9e-82 40041000086 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 40041000087 active site 40041000088 HMMPfam hit to PF00156, Phosphoribosyltransferase, score 2.2e-33 40041000089 ATP-dependent Zn proteases [Posttranslational modification, protein turnover, chaperones]; Region: HflB; COG0465 40041000090 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 40041000091 Walker A motif; other site 40041000092 ATP binding site [chemical binding]; other site 40041000093 Walker B motif; other site 40041000094 arginine finger; other site 40041000095 Peptidase family M41; Region: Peptidase_M41; pfam01434 40041000096 2 probable transmembrane helices predicted for SZO00150 by TMHMM2.0 at aa 13-31 and 134-156 40041000097 HMMPfam hit to PF06480, Peptidase M41, FtsH extracellular, score 2.5e-36 40041000098 HMMPfam hit to PF00004, AAA ATPase, core, score 1.5e-94 40041000099 PS00017 ATP/GTP-binding site motif A (P-loop). 40041000100 PS00674 AAA-protein family signature. 40041000101 HMMPfam hit to PF01434, Peptidase M41, score 7.6e-108 40041000102 amino acid transporter; Region: 2A0306; TIGR00909 40041000103 C-terminus of AA_permease; Region: AA_permease_C; pfam13906 40041000104 HMMPfam hit to PF00324, Amino acid permease-associated region, score 3.6e-26 40041000105 12 probable transmembrane helices predicted for SZO00160 by TMHMM2.0 at aa 48-70, 74-96, 108-130, 171-193, 200-222, 237-259, 280-302, 331-353, 374-396, 401-418, 431-453 and 457-479 40041000106 PS00017 ATP/GTP-binding site motif A (P-loop). 40041000107 rod shape-determining protein MreC; Provisional; Region: PRK13922 40041000108 rod shape-determining protein MreC; Region: MreC; pfam04085 40041000109 1 probable transmembrane helix predicted for SZO00170 by TMHMM2.0 at aa 9-31 40041000110 HMMPfam hit to PF04085, Rod shape-determining protein MreC, score 1.3e-20 40041000111 6 probable transmembrane helices predicted for SZO00180 by TMHMM2.0 at aa 7-29, 33-52, 57-74, 78-100, 107-126 and 136-158 40041000112 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3883 40041000113 Surface antigen [General function prediction only]; Region: COG3942 40041000114 CHAP domain; Region: CHAP; pfam05257 40041000115 HMMPfam hit to PF05257, Cysteine, histidine-dependent amidohydrolase/peptidase, score 6.1e-38 40041000116 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 40041000117 Transposase; Region: DDE_Tnp_ISL3; pfam01610 40041000118 HMMPfam hit to PF01610, Transposase, IS204/IS1001/IS1096/IS1165, score 1.4e-47 40041000119 Predicted helix-turn-helix motif with score 1838.000, SD 5.45 at aa 119-140, sequence VSMTAIADRLSISTSTVMRKLN 40041000120 ribose-phosphate pyrophosphokinase; Provisional; Region: PRK02269 40041000121 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 40041000122 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 40041000123 active site 40041000124 PS00339 Aminoacyl-transfer RNA synthetases class-II signature 2. 40041000125 PS00114 Phosphoribosyl pyrophosphate synthetase signature. 40041000126 HMMPfam hit to PF00156, Phosphoribosyltransferase, score 7.7e-35 40041000127 PS00103 Purine/pyrimidine phosphoribosyl transferases signature. 40041000128 DNA repair protein RecO; Reviewed; Region: recO; PRK00085 40041000129 Recombination protein O N terminal; Region: RecO_N; pfam11967 40041000130 Recombination protein O C terminal; Region: RecO_C; pfam02565 40041000131 HMMPfam hit to PF02565, Recombination protein O, RecO, score 1.4e-14 40041000132 PS00190 Cytochrome c family heme-binding site signature. 40041000133 putative phosphate acyltransferase; Provisional; Region: PRK05331 40041000134 HMMPfam hit to PF02504, Fatty acid synthesis plsX protein, score 7.6e-132 40041000135 acyl carrier protein; Provisional; Region: PRK12449 40041000136 HMMPfam hit to PF00550, Phosphopantetheine-binding, score 1.1e-06 40041000137 phosphoribosylaminoimidazole-succinocarboxamide synthase; Reviewed; Region: PRK09362 40041000138 bacterial and archaeal 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_PurC; cd01415 40041000139 ATP binding site [chemical binding]; other site 40041000140 active site 40041000141 substrate binding site [chemical binding]; other site 40041000142 HMMPfam hit to PF01259, SAICAR synthetase, score 1.1e-106 40041000143 PS01057 SAICAR synthetase signature 1. 40041000144 PS01058 SAICAR synthetase signature 2. 40041000145 phosphoribosylformylglycinamidine synthase, clade II; Region: FGAM-synthase; TIGR01857 40041000146 AIR (aminoimidazole ribonucleotide) synthase related protein. This family includes Hydrogen expression/formation protein HypE, AIR synthases, FGAM (formylglycinamidine ribonucleotide) synthase and Selenophosphate synthetase (SelD). The N-terminal domain...; Region: PurM-like; cl10019 40041000147 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203 40041000148 dimerization interface [polypeptide binding]; other site 40041000149 ATP binding site [chemical binding]; other site 40041000150 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat2; cd02204 40041000151 dimerization interface [polypeptide binding]; other site 40041000152 ATP binding site [chemical binding]; other site 40041000153 Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740 40041000154 putative active site [active] 40041000155 catalytic triad [active] 40041000156 1 probable transmembrane helix predicted for SZO00260 by TMHMM2.0 at aa 7-29 40041000157 HMMPfam hit to PF00586, AIR synthase related protein, score 5.1e-05 40041000158 HMMPfam hit to PF02769, AIR synthase related protein, C-terminal, score 6.6e-33 40041000159 PS01159 WW/rsp5/WWP domain signature. 40041000160 amidophosphoribosyltransferase; Provisional; Region: PRK07272 40041000161 Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715 40041000162 active site 40041000163 tetramer interface [polypeptide binding]; other site 40041000164 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 40041000165 active site 40041000166 PS00443 Glutamine amidotransferases class-II active site. 40041000167 HMMPfam hit to PF00310, Glutamine amidotransferase, class-II, score 2e-42 40041000168 HMMPfam hit to PF00156, Phosphoribosyltransferase, score 2.4e-10 40041000169 PS00103 Purine/pyrimidine phosphoribosyl transferases signature. 40041000170 phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385 40041000171 PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196 40041000172 dimerization interface [polypeptide binding]; other site 40041000173 putative ATP binding site [chemical binding]; other site 40041000174 HMMPfam hit to PF00586, AIR synthase related protein, score 2.3e-71 40041000175 HMMPfam hit to PF02769, AIR synthase related protein, C-terminal, score 6.3e-45 40041000176 phosphoribosylglycinamide formyltransferase; Reviewed; Region: purN; PRK05647 40041000177 Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645 40041000178 active site 40041000179 substrate binding site [chemical binding]; other site 40041000180 cosubstrate binding site; other site 40041000181 catalytic site [active] 40041000182 HMMPfam hit to PF00551, Formyl transferase, N-terminal, score 2e-56 40041000183 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881 40041000184 Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal ATIC formylase domain that formylates...; Region: IMPCH; cd01421 40041000185 purine monophosphate binding site [chemical binding]; other site 40041000186 dimer interface [polypeptide binding]; other site 40041000187 putative catalytic residues [active] 40041000188 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; smart00798 40041000189 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; cl03362 40041000190 HMMPfam hit to PF02142, MGS-like, score 5.3e-51 40041000191 HMMPfam hit to PF01808, AICARFT/IMPCHase bienzyme, formylation region, score 1.2e-144 40041000192 Surface antigen [General function prediction only]; Region: COG3942 40041000193 CHAP domain; Region: CHAP; pfam05257 40041000194 Bacterial SH3 domain; Region: SH3_5; pfam08460 40041000195 HMMPfam hit to PF08460, SH3, type-5 bacterial, score 7.5e-22 40041000196 HMMPfam hit to PF05257, Cysteine, histidine-dependent amidohydrolase/peptidase, score 9.1e-31 40041000197 phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885 40041000198 Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844 40041000199 Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Region: GARS_A; pfam01071 40041000200 Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843 40041000201 HMMPfam hit to PF02844, Phosphoribosylglycinamide synthetase, score 1.3e-38 40041000202 HMMPfam hit to PF01071, Phosphoribosylglycinamide synthetase, score 3.9e-119 40041000203 PS00184 Phosphoribosylglycinamide synthetase signature. 40041000204 HMMPfam hit to PF02843, Phosphoribosylglycinamide synthetase, score 1.6e-14 40041000205 Phosphoribosylcarboxyaminoimidazole (NCAIR) mutase [Nucleotide transport and metabolism]; Region: PurE; COG0041 40041000206 HMMPfam hit to PF00731, 1-(5-Phosphoribosyl)-5-amino-4-imidazole-carboxylate (AIR) carboxylase, score 1.2e-87 40041000207 phosphoribosylaminoimidazole carboxylase ATPase subunit; Reviewed; Region: PRK06019 40041000208 ATP-grasp domain; Region: ATP-grasp; pfam02222 40041000209 HMMPfam hit to PF02222, ATP-grasp fold, ATP-dependent carboxylate-amine ligase-type, score 4.3e-69 40041000210 Ortholog of S. equi 4047 (FM204883) SEQ0036 40041000211 Ortholog of S. equi 4047 (FM204883) SEQ0036a 40041000212 adenylosuccinate lyase; Provisional; Region: PRK07492 40041000213 Adenylsuccinate lyase (ASL)_subgroup 1; Region: Adenylsuccinate_lyase_1; cd01360 40041000214 tetramer interface [polypeptide binding]; other site 40041000215 active site 40041000216 HMMPfam hit to PF00206, Fumarate lyase, score 1.9e-89 40041000217 PS00163 Fumarate lyases signature. 40041000218 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 40041000219 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 40041000220 non-specific DNA binding site [nucleotide binding]; other site 40041000221 salt bridge; other site 40041000222 sequence-specific DNA binding site [nucleotide binding]; other site 40041000223 HMMPfam hit to PF01381, Helix-turn-helix type 3, score 7.1e-08 40041000224 Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080 40041000225 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 40041000226 Walker A motif; other site 40041000227 ATP binding site [chemical binding]; other site 40041000228 Walker B motif; other site 40041000229 arginine finger; other site 40041000230 Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491 40041000231 HMMPfam hit to PF05496, DNA helicase, Holliday junction RuvB type, N-terminal, score 2.4e-26 40041000232 HMMPfam hit to PF00004, AAA ATPase, core, score 7.2e-31 40041000233 PS00017 ATP/GTP-binding site motif A (P-loop). 40041000234 HMMPfam hit to PF05491, DNA helicase, Holliday junction RuvB type, C-terminal, score 1.6e-52 40041000235 Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394 40041000236 Low molecular weight phosphatase family; Region: LMWPc; cd00115 40041000237 active site 40041000238 HMMPfam hit to PF01451, Protein-tyrosine phosphatase, low molecular weight, score 1.9e-30 40041000239 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4642 40041000240 1 probable transmembrane helix predicted for SZO00420 by TMHMM2.0 at aa 20-39 40041000241 HMMPfam hit to PF02493, MORN motif, score 3.6e-05 40041000242 HMMPfam hit to PF02493, MORN motif, score 0.001 40041000243 HMMPfam hit to PF02493, MORN motif, score 0.00052 40041000244 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 40041000245 glucans biosynthesis protein; Provisional; Region: opgC; PRK03854 40041000246 yrhL-like subfamily of SGNH-hydrolases, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase_yrhL_like; cd01840 40041000247 catalytic triad [active] 40041000248 catalytic triad [active] 40041000249 oxyanion hole [active] 40041000250 HMMPfam hit to PF01757, Acyltransferase 3, score 1.8e-30 40041000251 11 probable transmembrane helices predicted for SZO00430 by TMHMM2.0 at aa 5-23, 27-49, 69-90, 131-153, 166-188, 192-214, 235-257, 261-283, 295-317, 327-349 and 370-392 40041000252 bifunctional acetaldehyde-CoA/alcohol dehydrogenase; Provisional; Region: PRK13805 40041000253 Coenzyme A acylating aldehyde dehydrogenase (ACDH), ALDH family 20-like; Region: ALDH_F20_ACDH; cd07122 40041000254 putative catalytic cysteine [active] 40041000255 C-terminal alcohol dehydrogenase domain of the acetaldehyde dehydrogenase-alcohol dehydrogenase bifunctional two-domain protein (AAD); Region: AAD_C; cd08178 40041000256 putative active site [active] 40041000257 metal binding site [ion binding]; metal-binding site 40041000258 HMMPfam hit to PF00171, Aldehyde dehydrogenase, score 3.4e-07 40041000259 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 40041000260 HMMPfam hit to PF00465, Iron-containing alcohol dehydrogenase, score 8.8e-143 40041000261 PS00913 Iron-containing alcohol dehydrogenases signature 1. 40041000262 PS00060 Iron-containing alcohol dehydrogenases signature 2. 40041000263 formaldehyde dehydrogenase (FDH)-like; Region: FDH_like_ADH2; cd08286 40041000264 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 40041000265 catalytic Zn binding site [ion binding]; other site 40041000266 structural Zn binding site [ion binding]; other site 40041000267 NAD(P) binding site [chemical binding]; other site 40041000268 HMMPfam hit to PF08240, Alcohol dehydrogenase GroES-like, score 1.8e-40 40041000269 PS00059 Zinc-containing alcohol dehydrogenases signature. 40041000270 HMMPfam hit to PF00107, Alcohol dehydrogenase, zinc-binding, score 8.8e-36 40041000271 ethanol-active dehydrogenase/acetaldehyde-active reductase; Provisional; Region: PRK09422 40041000272 Cinnamyl alcohol dehydrogenases (CAD); Region: CAD3; cd08297 40041000273 NAD binding site [chemical binding]; other site 40041000274 substrate binding site [chemical binding]; other site 40041000275 catalytic Zn binding site [ion binding]; other site 40041000276 tetramer interface [polypeptide binding]; other site 40041000277 structural Zn binding site [ion binding]; other site 40041000278 HMMPfam hit to PF08240, Alcohol dehydrogenase GroES-like, score 4.1e-52 40041000279 PS00190 Cytochrome c family heme-binding site signature. 40041000280 PS00059 Zinc-containing alcohol dehydrogenases signature. 40041000281 HMMPfam hit to PF00107, Alcohol dehydrogenase, zinc-binding, score 1.7e-39 40041000282 Threonine synthase [Amino acid transport and metabolism]; Region: ThrC; COG0498 40041000283 Threonine synthase catalyzes the final step of threonine biosynthesis. The conversion of O-phosphohomoserine into threonine and inorganic phosphate is pyridoxal 5'-phosphate dependent. The Thr-synth_1 CD includes members from higher plants; Region: Thr-synth_2; cd01560 40041000284 pyridoxal 5'-phosphate binding site [chemical binding]; other site 40041000285 catalytic residue [active] 40041000286 HMMPfam hit to PF00291, Pyridoxal phosphate-dependent enzyme, beta subunit, score 2.4e-10 40041000287 PS00165 Serine/threonine dehydratases pyridoxal-phosphate attachment site. 40041000288 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 40041000289 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Thermotoga marina NorM; Region: MATE_NorM_like; cd13137 40041000290 HMMPfam hit to PF01554, Multi antimicrobial extrusion protein MatE, score 8.9e-21 40041000291 9 probable transmembrane helices predicted for SZO00480 by TMHMM2.0 at aa 27-49, 54-73, 86-108, 128-150, 163-182, 186-208, 306-328, 343-365 and 385-407 40041000292 HMMPfam hit to PF01554, Multi antimicrobial extrusion protein MatE, score 1.3e-24 40041000293 30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596 40041000294 HMMPfam hit to PF00338, Ribosomal protein S10, score 7.6e-60 40041000295 PS00361 Ribosomal protein S10 signature. 40041000296 50S ribosomal protein L3; Validated; Region: rplC; PRK00001 40041000297 HMMPfam hit to PF00297, Ribosomal protein L3, score 5.1e-93 40041000298 PS00474 Ribosomal protein L3 signature. 40041000299 50S ribosomal protein L4; Provisional; Region: rplD; PRK05319 40041000300 HMMPfam hit to PF00573, Ribosomal protein L4/L1e, score 1.8e-72 40041000301 50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738 40041000302 HMMPfam hit to PF00276, Ribosomal protein L25/L23, score 5.4e-33 40041000303 PS00050 Ribosomal protein L23 signature. 40041000304 50S ribosomal protein L2; Validated; Region: rplB; PRK09374 40041000305 Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181 40041000306 Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947 40041000307 HMMPfam hit to PF00181, Ribosomal protein L2, score 8.3e-48 40041000308 HMMPfam hit to PF03947, Ribosomal protein L2, score 1.5e-87 40041000309 PS00467 Ribosomal protein L2 signature. 40041000310 30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357 40041000311 HMMPfam hit to PF00203, Ribosomal protein S19/S15, score 3.2e-51 40041000312 PS00323 Ribosomal protein S19 signature. 40041000313 Ribosomal protein L22/L17e. L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit. It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336 40041000314 putative translocon binding site; other site 40041000315 protein-rRNA interface [nucleotide binding]; other site 40041000316 HMMPfam hit to PF00237, Ribosomal protein L22/L17, score 2.4e-60 40041000317 PS00464 Ribosomal protein L22 signature. 40041000318 30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310 40041000319 K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3 is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel. The KH...; Region: 30S_S3_KH; cd02412 40041000320 G-X-X-G motif; other site 40041000321 Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189 40041000322 HMMPfam hit to PF00417, Ribosomal protein S3, N-terminal, score 5e-29 40041000323 HMMPfam hit to PF07650, K Homology, type 2, score 4.7e-23 40041000324 HMMPfam hit to PF00189, Ribosomal protein S3, C-terminal, score 1.4e-50 40041000325 PS00548 Ribosomal protein S3 signature. 40041000326 Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433 40041000327 23S rRNA interface [nucleotide binding]; other site 40041000328 5S rRNA interface [nucleotide binding]; other site 40041000329 putative antibiotic binding site [chemical binding]; other site 40041000330 L25 interface [polypeptide binding]; other site 40041000331 L27 interface [polypeptide binding]; other site 40041000332 HMMPfam hit to PF00252, Ribosomal protein L16, score 1.7e-81 40041000333 PS00586 Ribosomal protein L16 signature 1. 40041000334 PS00701 Ribosomal protein L16 signature 2. 40041000335 Ribosomal L29 protein/HIP. L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals. L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427 40041000336 23S rRNA interface [nucleotide binding]; other site 40041000337 putative translocon interaction site; other site 40041000338 signal recognition particle (SRP54) interaction site; other site 40041000339 L23 interface [polypeptide binding]; other site 40041000340 trigger factor interaction site; other site 40041000341 HMMPfam hit to PF00831, Ribosomal protein L29, score 2.1e-28 40041000342 30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610 40041000343 HMMPfam hit to PF00366, Ribosomal protein S17, score 1.6e-36 40041000344 PS00056 Ribosomal protein S17 signature. 40041000345 50S ribosomal protein L14; Validated; Region: rplN; PRK05483 40041000346 HMMPfam hit to PF00238, Ribosomal protein L14b/L23e, score 8.6e-78 40041000347 PS00049 Ribosomal protein L14 signature. 40041000348 50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004 40041000349 KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089 40041000350 RNA binding site [nucleotide binding]; other site 40041000351 HMMPfam hit to PF00467, KOW, score 6.6e-09 40041000352 PS01108 Ribosomal protein L24 signature. 40041000353 50S ribosomal protein L5; Validated; Region: rplE; PRK00010 40041000354 Ribosomal protein L5; Region: Ribosomal_L5; pfam00281 40041000355 ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673 40041000356 HMMPfam hit to PF00281, Ribosomal protein L5, score 1.3e-29 40041000357 PS00358 Ribosomal protein L5 signature. 40041000358 HMMPfam hit to PF00673, Ribosomal protein L5, score 6.3e-53 40041000359 30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08061 40041000360 HMMPfam hit to PF00253, Ribosomal protein S14, score 1.2e-19 40041000361 PS00527 Ribosomal protein S14 signature. 40041000362 30S ribosomal protein S8; Validated; Region: rpsH; PRK00136 40041000363 HMMPfam hit to PF00410, Ribosomal protein S8, score 4.8e-76 40041000364 PS00053 Ribosomal protein S8 signature. 40041000365 50S ribosomal protein L6; Validated; Region: rplF; PRK05498 40041000366 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 40041000367 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 40041000368 HMMPfam hit to PF00347, Ribosomal protein L6, score 1.5e-24 40041000369 HMMPfam hit to PF00347, Ribosomal protein L6, score 2.2e-30 40041000370 PS00525 Ribosomal protein L6 signature 1. 40041000371 Ribosomal L18/L5e: L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432 40041000372 5S rRNA interface [nucleotide binding]; other site 40041000373 L27 interface [polypeptide binding]; other site 40041000374 23S rRNA interface [nucleotide binding]; other site 40041000375 L5 interface [polypeptide binding]; other site 40041000376 HMMPfam hit to PF00861, Ribosomal protein L18/L5, score 7.3e-56 40041000377 30S ribosomal protein S5; Validated; Region: rpsE; PRK00550 40041000378 Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333 40041000379 Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719 40041000380 HMMPfam hit to PF00333, Ribosomal protein S5, N-terminal, score 1.3e-42 40041000381 PS00585 Ribosomal protein S5 signature. 40041000382 PS00589 PTS HPR component serine phosphorylation site signature. 40041000383 HMMPfam hit to PF03719, Ribosomal protein S5, C-terminal, score 1.2e-33 40041000384 Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins that...; Region: Ribosomal_L30; cd01658 40041000385 23S rRNA binding site [nucleotide binding]; other site 40041000386 HMMPfam hit to PF00327, Ribosomal protein L30, score 2.9e-14 40041000387 PS00634 Ribosomal protein L30 signature. 40041000388 50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592 40041000389 HMMPfam hit to PF01305, Ribosomal protein L15, score 1.5e-58 40041000390 HMMPfam hit to PF00256, Ribosomal protein L15, score 3.2e-11 40041000391 PS00475 Ribosomal protein L15 signature. 40041000392 preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204 40041000393 SecY translocase; Region: SecY; pfam00344 40041000394 10 probable transmembrane helices predicted for SZO00700 by TMHMM2.0 at aa 20-42, 66-88, 117-139, 149-168, 175-197, 212-234, 267-289, 304-326, 368-390 and 395-414 40041000395 HMMPfam hit to PF00344, SecY protein, score 3.8e-167 40041000396 PS00755 Protein secY signature 1. 40041000397 PS00756 Protein secY signature 2. 40041000398 PS00095 C-5 cytosine-specific DNA methylases C-terminal signature. 40041000399 adenylate kinase; Reviewed; Region: adk; PRK00279 40041000400 Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428 40041000401 AMP-binding site [chemical binding]; other site 40041000402 ATP-AMP (Ap5A)-binding site [chemical binding]; other site 40041000403 HMMPfam hit to PF00406, Adenylate kinase, score 4.2e-87 40041000404 PS00113 Adenylate kinase signature. 40041000405 S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451 40041000406 rRNA binding site [nucleotide binding]; other site 40041000407 predicted 30S ribosome binding site; other site 40041000408 HMMPfam hit to PF01176, S1, IF1 type, score 1.5e-35 40041000409 Ribosomal protein L36; Region: Ribosomal_L36; pfam00444 40041000410 HMMPfam hit to PF00444, Ribosomal protein L36, score 2.4e-17 40041000411 PS00828 Ribosomal protein L36 signature. 40041000412 Ribosomal protein S13 [Translation, ribosomal structure and biogenesis]; Region: RpsM; COG0099 40041000413 30S ribosomal protein S13; Region: bact_S13; TIGR03631 40041000414 HMMPfam hit to PF00416, Ribosomal protein S13, score 5.4e-55 40041000415 PS00646 Ribosomal protein S13 signature. 40041000416 30S ribosomal protein S11; Validated; Region: PRK05309 40041000417 HMMPfam hit to PF00411, Ribosomal protein S11, score 2.1e-72 40041000418 PS00054 Ribosomal protein S11 signature. 40041000419 DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182 40041000420 N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928 40041000421 alphaNTD homodimer interface [polypeptide binding]; other site 40041000422 alphaNTD - beta interaction site [polypeptide binding]; other site 40041000423 alphaNTD - beta' interaction site [polypeptide binding]; other site 40041000424 Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118 40041000425 HMMPfam hit to PF01193, RNA polymerase, dimerisation, score 6e-26 40041000426 HMMPfam hit to PF01000, RNA polymerase, insert, score 1.5e-55 40041000427 HMMPfam hit to PF03118, RNA polymerase, alpha subunit, C-terminal, score 1.3e-31 40041000428 50S ribosomal protein L17; Validated; Region: rplQ; PRK05591 40041000429 HMMPfam hit to PF01196, Ribosomal protein L17, score 1.5e-62 40041000430 PS01167 Ribosomal protein L17 signature. 40041000431 Ortholog of S. equi 4047 (FM204883) SEQ0083 40041000432 6 probable transmembrane helices predicted for SZO00800 by TMHMM2.0 at aa 43-62, 90-112, 121-143, 148-170, 191-213 and 228-250 40041000433 Domain of unknown function (DUF4176); Region: DUF4176; pfam13780 40041000434 H+ Antiporter protein; Region: 2A0121; TIGR00900 40041000435 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 40041000436 putative substrate translocation pore; other site 40041000437 10 probable transmembrane helices predicted for SZO00820 by TMHMM2.0 at aa 40-62, 72-94, 101-123, 164-186, 216-238, 253-275, 282-301, 306-328, 340-362 and 366-388 40041000438 HMMPfam hit to PF07690, Major facilitator superfamily MFS-1, score 5.2e-15 40041000439 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 40041000440 Collagen triple helix repeat (20 copies); Region: Collagen; pfam01391 40041000441 Collagen triple helix repeat (20 copies); Region: Collagen; pfam01391 40041000442 Collagen triple helix repeat (20 copies); Region: Collagen; pfam01391 40041000443 Collagen triple helix repeat (20 copies); Region: Collagen; pfam01391 40041000444 Collagen triple helix repeat (20 copies); Region: Collagen; pfam01391 40041000445 Collagen triple helix repeat (20 copies); Region: Collagen; pfam01391 40041000446 Collagen triple helix repeat (20 copies); Region: Collagen; pfam01391 40041000447 Gram positive anchor; Region: Gram_pos_anchor; pfam00746 40041000448 1 probable transmembrane helix predicted for SZO00830 by TMHMM2.0 at aa 13-35 40041000449 HMMPfam hit to PF01391, Collagen triple helix repeat, score 1.3e-12 40041000450 HMMPfam hit to PF01391, Collagen triple helix repeat, score 2.1e-15 40041000451 HMMPfam hit to PF01391, Collagen triple helix repeat, score 2.1e-15 40041000452 HMMPfam hit to PF01391, Collagen triple helix repeat, score 2.1e-15 40041000453 HMMPfam hit to PF01391, Collagen triple helix repeat, score 2.1e-15 40041000454 HMMPfam hit to PF00746, Surface protein from Gram-positive cocci, anchor region, score 5.8e-07 40041000455 PS00343 Gram-positive cocci surface proteins 'anchoring' hexapeptide. 40041000456 Collagen triple helix repeat (20 copies); Region: Collagen; pfam01391 40041000457 Collagen triple helix repeat (20 copies); Region: Collagen; pfam01391 40041000458 Gram positive anchor; Region: Gram_pos_anchor; pfam00746 40041000459 HMMPfam hit to PF01391, Collagen triple helix repeat, score 4.2e-13 40041000460 HMMPfam hit to PF01391, Collagen triple helix repeat, score 1.2e-14 40041000461 HMMPfam hit to PF01391, Collagen triple helix repeat, score 1.7e-14 40041000462 HMMPfam hit to PF00746, Surface protein from Gram-positive cocci, anchor region, score 2.8e-11 40041000463 PS00343 Gram-positive cocci surface proteins 'anchoring' hexapeptide. 40041000464 isopentenyl-diphosphate delta-isomerase, type 1; Region: IPP_isom_1; TIGR02150 40041000465 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_34; cd04693 40041000466 nudix motif; other site 40041000467 HMMPfam hit to PF00293, NUDIX hydrolase, core, score 6.4e-25 40041000468 PS00893 mutT domain signature. 40041000469 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: ipk; PRK00128 40041000470 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 40041000471 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 40041000472 HMMPfam hit to PF00288, GHMP kinase, score 1.3e-18 40041000473 HMMPfam hit to PF08544, GHMP kinase, C-terminal, score 3.1e-09 40041000474 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 40041000475 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 40041000476 putative Zn2+ binding site [ion binding]; other site 40041000477 putative DNA binding site [nucleotide binding]; other site 40041000478 HMMPfam hit to PF01047, Bacterial regulatory protein, MarR, score 4.5e-15 40041000479 Predicted helix-turn-helix motif with score 2017.000, SD 6.06 at aa 52-73, sequence LTNTDLAKRLNISQAAVTKAIK 40041000480 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 40041000481 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 40041000482 HMMPfam hit to PF00005, ABC transporter related, score 1.3e-46 40041000483 PS00211 ABC transporters family signature. 40041000484 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 40041000485 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 40041000486 ABC-ATPase subunit interface; other site 40041000487 dimer interface [polypeptide binding]; other site 40041000488 putative PBP binding regions; other site 40041000489 HMMPfam hit to PF00950, ABC-3, score 1.6e-91 40041000490 7 probable transmembrane helices predicted for SZO00890 by TMHMM2.0 at aa 10-32, 53-75, 85-107, 134-156, 176-198, 219-241 and 245-267 40041000491 tyrosyl-tRNA synthetase; Validated; Region: PRK05912 40041000492 catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805 40041000493 active site 40041000494 HIGH motif; other site 40041000495 dimer interface [polypeptide binding]; other site 40041000496 KMSKS motif; other site 40041000497 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 40041000498 RNA binding surface [nucleotide binding]; other site 40041000499 HMMPfam hit to PF01479, RNA-binding S4, score 3.9e-06 40041000500 HMMPfam hit to PF00579, Aminoacyl-tRNA synthetase, class Ib, score 4.8e-117 40041000501 PS00178 Aminoacyl-transfer RNA synthetases class-I signature. 40041000502 Membrane carboxypeptidase (penicillin-binding protein) [Cell envelope biogenesis, outer membrane]; Region: MrcB; COG0744 40041000503 Transglycosylase; Region: Transgly; pfam00912 40041000504 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 40041000505 1 probable transmembrane helix predicted for SZO00910 by TMHMM2.0 at aa 38-60 40041000506 HMMPfam hit to PF00912, Glycosyl transferase, family 51, score 1.6e-76 40041000507 PS00402 Binding-protein-dependent transport systems inner membrane comp. sign. 40041000508 HMMPfam hit to PF00905, Penicillin-binding protein, transpeptidase, score 5.1e-18 40041000509 PS00017 ATP/GTP-binding site motif A (P-loop). 40041000510 Helix-turn-helix domain; Region: HTH_28; pfam13518 40041000511 Winged helix-turn helix; Region: HTH_29; pfam13551 40041000512 Homeodomain-like domain; Region: HTH_32; pfam13565 40041000513 Integrase core domain; Region: rve; pfam00665 40041000514 HMMPfam hit to PF00665, Integrase, catalytic core, score 1.1e-18 40041000515 PS00017 ATP/GTP-binding site motif A (P-loop). 40041000516 DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405 40041000517 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585 40041000518 RNA polymerase Rpb2, domain 2; Region: RNA_pol_Rpb2_2; pfam04561 40041000519 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585 40041000520 RNA polymerase beta subunit external 1 domain; Region: RNA_pol_Rpb2_45; pfam10385 40041000521 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 40041000522 RPB1 interaction site [polypeptide binding]; other site 40041000523 RPB10 interaction site [polypeptide binding]; other site 40041000524 RPB11 interaction site [polypeptide binding]; other site 40041000525 RPB3 interaction site [polypeptide binding]; other site 40041000526 RPB12 interaction site [polypeptide binding]; other site 40041000527 HMMPfam hit to PF04563, RNA polymerase, beta subunit, protrusion, score 3.1e-50 40041000528 HMMPfam hit to PF04561, RNA polymerase Rpb2, domain 2, score 4.7e-08 40041000529 HMMPfam hit to PF04561, RNA polymerase Rpb2, domain 2, score 1.7e-12 40041000530 HMMPfam hit to PF04565, RNA polymerase Rpb2, domain 3, score 1.6e-39 40041000531 HMMPfam hit to PF00562, RNA polymerase Rpb2, domain 6, score 1.3e-211 40041000532 PS01166 RNA polymerases beta chain signature. 40041000533 HMMPfam hit to PF04560, RNA polymerase Rpb2, domain 7, score 1.1e-49 40041000534 DNA-directed RNA polymerase subunit beta'; Provisional; Region: PRK00566 40041000535 RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997 40041000536 RNA polymerase I subunit A N-terminus; Region: RPOLA_N; smart00663 40041000537 RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983 40041000538 RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000 40041000539 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 40041000540 Rpb1 (beta') - Rpb6 (omega) interaction site [polypeptide binding]; other site 40041000541 Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site 40041000542 G-loop; other site 40041000543 DNA binding site [nucleotide binding] 40041000544 HMMPfam hit to PF04997, RNA polymerase Rpb1, domain 1, score 1.5e-152 40041000545 HMMPfam hit to PF00623, RNA polymerase, alpha subunit, score 5.1e-83 40041000546 HMMPfam hit to PF04983, RNA polymerase Rpb1, domain 3, score 2.9e-73 40041000547 HMMPfam hit to PF05000, RNA polymerase Rpb1, domain 4, score 4.2e-23 40041000548 HMMPfam hit to PF04998, RNA polymerase Rpb1, domain 5, score 1.7e-78 40041000549 Acyltransferase family; Region: Acyl_transf_3; pfam01757 40041000550 10 probable transmembrane helices predicted for SZO00950 by TMHMM2.0 at aa 13-35, 50-67, 87-104, 119-141, 154-176, 196-215, 228-247, 251-273, 286-303 and 316-338 40041000551 Protein of unknown function (DUF1033); Region: DUF1033; pfam06279 40041000552 HMMPfam hit to PF06279, Protein of unknown function DUF1033, score 4.8e-68 40041000553 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4652 40041000554 Protein of unknown function (DUF1430); Region: DUF1430; pfam07242 40041000555 8 probable transmembrane helices predicted for SZO00970 by TMHMM2.0 at aa 5-24, 153-175, 203-225, 229-260, 273-295, 563-585, 605-627 and 631-650 40041000556 HMMPfam hit to PF07242, Bacteriocin-associated integral membrane protein, score 1.6e-37 40041000557 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 40041000558 putative bacteriocin export ABC transporter, lactococcin 972 group; Region: L_ocin_972_ABC; TIGR03608 40041000559 Walker A/P-loop; other site 40041000560 ATP binding site [chemical binding]; other site 40041000561 Q-loop/lid; other site 40041000562 ABC transporter signature motif; other site 40041000563 Walker B; other site 40041000564 D-loop; other site 40041000565 H-loop/switch region; other site 40041000566 HMMPfam hit to PF00005, ABC transporter related, score 8.9e-53 40041000567 PS00017 ATP/GTP-binding site motif A (P-loop). 40041000568 PS00092 N-6 Adenine-specific DNA methylases signature. 40041000569 Type II/IV secretion system protein; Region: T2SE; pfam00437 40041000570 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 40041000571 Walker A motif; other site 40041000572 ATP binding site [chemical binding]; other site 40041000573 Walker B motif; other site 40041000574 HMMPfam hit to PF00437, Bacterial type II secretion system protein E, score 5.2e-29 40041000575 PS00017 ATP/GTP-binding site motif A (P-loop). 40041000576 PS00662 Bacterial type II secretion system protein E signature. 40041000577 Type II secretory pathway, component PulF [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulF; COG1459 40041000578 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 40041000579 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 40041000580 HMMPfam hit to PF00482, Bacterial type II secretion system protein, score 1.2e-16 40041000581 3 probable transmembrane helices predicted for SZO01000 by TMHMM2.0 at aa 108-130, 145-167 and 299-321 40041000582 HMMPfam hit to PF00482, Bacterial type II secretion system protein, score 6e-20 40041000583 Competence protein ComGC [Intracellular trafficking and secretion]; Region: ComGC; COG4537 40041000584 HMMPfam hit to PF07963, Prepilin-type cleavage/methylation, N-terminal, score 6.8e-06 40041000585 1 probable transmembrane helix predicted for SZO01010 by TMHMM2.0 at aa 15-37 40041000586 1 probable transmembrane helix predicted for SZO01020 by TMHMM2.0 at aa 12-34 40041000587 Type II secretory pathway pseudopilin; Region: PulG; pfam11773 40041000588 1 probable transmembrane helix predicted for SZO01030 by TMHMM2.0 at aa 4-21 40041000589 Competence protein ComGF [Intracellular trafficking and secretion]; Region: ComGF; COG4940 40041000590 1 probable transmembrane helix predicted for SZO01040 by TMHMM2.0 at aa 9-31 40041000591 PS00012 Phosphopantetheine attachment site. 40041000592 1 probable transmembrane helix predicted for SZO01050 by TMHMM2.0 at aa 9-31 40041000593 Methyltransferase domain; Region: Methyltransf_31; pfam13847 40041000594 Methyltransferase domain; Region: Methyltransf_26; pfam13659 40041000595 acetate kinase A/propionate kinase 2; Reviewed; Region: PRK00180 40041000596 propionate/acetate kinase; Provisional; Region: PRK12379 40041000597 HMMPfam hit to PF00871, Acetate and butyrate kinase, score 2.1e-201 40041000598 PS01076 Acetate and butyrate kinases family signature 2. 40041000599 1 probable transmembrane helix predicted for SZO01080 by TMHMM2.0 at aa 7-29 40041000600 Transcriptional antiterminator [Transcription]; Region: BglG; COG3711 40041000601 PRD domain; Region: PRD; pfam00874 40041000602 PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568 40041000603 active site 40041000604 P-loop; other site 40041000605 phosphorylation site [posttranslational modification] 40041000606 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 40041000607 active site 40041000608 phosphorylation site [posttranslational modification] 40041000609 HMMPfam hit to PF00874, PRD, score 9.3e-16 40041000610 HMMPfam hit to PF00359, Phosphotransferase system, phosphoenolpyruvate-dependent sugar EIIA 2, score 1.8e-26 40041000611 PS00372 PTS EIIA domains phosphorylation site signature 2. 40041000612 PTS_IIB_ascorbate: subunit IIB of enzyme II (EII) of the L-ascorbate-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is an L-ascorbate-specific permease with two cytoplasmic subunits (IIA and IIB) and a...; Region: PTS_IIB_ascorbate; cd05563 40041000613 active site 40041000614 P-loop; other site 40041000615 phosphorylation site [posttranslational modification] 40041000616 HMMPfam hit to PF02302, Phosphotransferase system, lactose/cellobiose-specific IIB subunit, score 7.4e-26 40041000617 PTS system ascorbate-specific transporter subunit IIC; Reviewed; Region: ulaA; PRK09410 40041000618 HMMPfam hit to PF04215, sugar-specific permease, SgaT/UlaA, score 1.5e-115 40041000619 11 probable transmembrane helices predicted for SZO01110 by TMHMM2.0 at aa 4-26, 33-55, 86-108, 115-137, 141-163, 220-242, 257-279, 311-333, 337-359, 371-393 and 418-440 40041000620 PS00453 FKBP-type peptidyl-prolyl cis-trans isomerase signature 1. 40041000621 PS00017 ATP/GTP-binding site motif A (P-loop). 40041000622 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 40041000623 TPP-binding site [chemical binding]; other site 40041000624 dimer interface [polypeptide binding]; other site 40041000625 HMMPfam hit to PF00456, Transketolase, N-terminal, score 2.1e-38 40041000626 Transketolase, C-terminal subunit [Carbohydrate transport and metabolism]; Region: COG3958 40041000627 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 40041000628 PYR/PP interface [polypeptide binding]; other site 40041000629 dimer interface [polypeptide binding]; other site 40041000630 TPP binding site [chemical binding]; other site 40041000631 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 40041000632 HMMPfam hit to PF02779, Transketolase, central region, score 6.1e-18 40041000633 HMMPfam hit to PF02780, Transketolase, C-terminal, score 1.4e-17 40041000634 Predicted metalloendopeptidase [Posttranslational modification, protein turnover, chaperones]; Region: PepO; COG3590 40041000635 Peptidase family M13 includes neprilysin, endothelin-converting enzyme I; Region: M13; cd08662 40041000636 active site 40041000637 Zn binding site [ion binding]; other site 40041000638 HMMPfam hit to PF05649, Peptidase M13, score 1.8e-172 40041000639 HMMPfam hit to PF01431, Peptidase M13, neprilysin, score 2.5e-73 40041000640 PS00142 Neutral zinc metallopeptidases, zinc-binding region signature. 40041000641 elongation factor Ts; Provisional; Region: tsf; PRK09377 40041000642 UBA/TS-N domain; Region: UBA; pfam00627 40041000643 Elongation factor TS; Region: EF_TS; pfam00889 40041000644 HMMPfam hit to PF00889, Translation elongation factor EFTs/EF1B, dimerisation, score 8.6e-54 40041000645 HMMPfam hit to PF00627, Ubiquitin-associated_translation elongation factor EF1B, N-terminal, score 5.8e-12 40041000646 Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425 40041000647 rRNA interaction site [nucleotide binding]; other site 40041000648 S8 interaction site; other site 40041000649 putative laminin-1 binding site; other site 40041000650 HMMPfam hit to PF00318, Ribosomal protein S2, score 1.5e-100 40041000651 PS00962 Ribosomal protein S2 signature 1. 40041000652 alkyl hydroperoxide reductase subunit F; Provisional; Region: PRK15317 40041000653 Alkyl hydroperoxide reductase F subunit (AhpF) N-terminal domain (NTD) family, N-terminal TRX-fold subdomain; AhpF is a homodimeric flavoenzyme which catalyzes the NADH-dependent reduction of the peroxiredoxin AhpC, which in turn catalyzes the reduction...; Region: AhpF_NTD_N; cd02974 40041000654 catalytic residue [active] 40041000655 TRX-GRX-like family, Alkyl hydroperoxide reductase F subunit (AhpF) N-terminal domain (NTD) subfamily, C-terminal TRX-fold subdomain; AhpF is a homodimeric flavoenzyme which catalyzes the NADH-dependent reduction of the peroxiredoxin AhpC, which then...; Region: AhpF_NTD_C; cd03026 40041000656 catalytic residues [active] 40041000657 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 40041000658 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 40041000659 HMMPfam hit to PF07992, FAD-dependent pyridine nucleotide-disulphide oxidoreductase, score 6.2e-51 40041000660 HMMPfam hit to PF00070, Pyridine nucleotide-disulphide oxidoreductase, NAD-binding region, score 4.5e-19 40041000661 PS00573 Pyridine nucleotide-disulphide oxidoreductases class-II active site. 40041000662 HMMPfam hit to PF00462, Glutaredoxin, score 0.0023 40041000663 peroxiredoxin; Region: AhpC; TIGR03137 40041000664 Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015 40041000665 dimer interface [polypeptide binding]; other site 40041000666 decamer (pentamer of dimers) interface [polypeptide binding]; other site 40041000667 catalytic triad [active] 40041000668 peroxidatic and resolving cysteines [active] 40041000669 HMMPfam hit to PF00578, Alkyl hydroperoxide reductase/ Thiol specific antioxidant/ Mal allergen, score 1.7e-45 40041000670 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 40041000671 DNA-binding site [nucleotide binding]; DNA binding site 40041000672 RNA-binding motif; other site 40041000673 HMMPfam hit to PF00313, Cold-shock protein, DNA-binding, score 1.5e-43 40041000674 PS00352 'Cold-shock' DNA-binding domain signature. 40041000675 Transcriptional repressor of class III stress genes [Transcription]; Region: CtsR; COG4463 40041000676 PS00430 TonB-dependent receptor proteins signature 1. 40041000677 HMMPfam hit to PF05848, Firmicute transcriptional repressor of class III stress genes, score 3.3e-99 40041000678 Predicted helix-turn-helix motif with score 1287.000, SD 3.57 at aa 26-47, sequence IKRSMLADSFQVVPSQINYVIK 40041000679 ATP-binding subunits of Clp protease and DnaK/DnaJ chaperones [Posttranslational modification, protein turnover, chaperones]; Region: clpA; COG0542 40041000680 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 40041000681 Walker A motif; other site 40041000682 ATP binding site [chemical binding]; other site 40041000683 Walker B motif; other site 40041000684 arginine finger; other site 40041000685 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 40041000686 Walker A motif; other site 40041000687 ATP binding site [chemical binding]; other site 40041000688 Walker B motif; other site 40041000689 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 40041000690 HMMPfam hit to PF02861, Clp, N-terminal, score 0.037 40041000691 PS00017 ATP/GTP-binding site motif A (P-loop). 40041000692 HMMPfam hit to PF02861, Clp, N-terminal, score 0.12 40041000693 HMMPfam hit to PF00004, AAA ATPase, core, score 7.9e-10 40041000694 PS00017 ATP/GTP-binding site motif A (P-loop). 40041000695 PS00870 Chaperonins clpA/B signature 1. 40041000696 HMMPfam hit to PF07724, ATPase AAA-2, score 7.4e-102 40041000697 PS00017 ATP/GTP-binding site motif A (P-loop). 40041000698 PS00871 Chaperonins clpA/B signature 2. 40041000699 CDS contains a frameshift after codon 62. Similar to Streptococcus agalactiae serotype III. Streptococcus agalactiae serotype III subname: full=uncharacterized protein gbs0225 subname: full=uncharacterized protein gbs0225 UniProt:Q8E7C9 (EMBL:AL766844) (135 aa) fasta scores: E()=3.4, 27.660% id in 141 aa 40041000700 1 probable transmembrane helix predicted for SZO01220 by TMHMM2.0 at aa 21-38 40041000701 1 probable transmembrane helix predicted for SZO01230 by TMHMM2.0 at aa 7-24 40041000702 Lipase. Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is "interfacial activation", the process of...; Region: Lipase; cl14883 40041000703 nucleophilic elbow; other site 40041000704 catalytic triad; other site 40041000705 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 40041000706 oligomerisation interface [polypeptide binding]; other site 40041000707 mobile loop; other site 40041000708 roof hairpin; other site 40041000709 HMMPfam hit to PF00166, Chaperonin Cpn10, score 2e-32 40041000710 PS00681 Chaperonins cpn10 signature. 40041000711 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 40041000712 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 40041000713 ring oligomerisation interface [polypeptide binding]; other site 40041000714 ATP/Mg binding site [chemical binding]; other site 40041000715 stacking interactions; other site 40041000716 hinge regions; other site 40041000717 HMMPfam hit to PF00118, Chaperonin Cpn60/TCP-1, score 4.3e-195 40041000718 PS00296 Chaperonins cpn60 signature. 40041000719 putative transposase OrfB; Reviewed; Region: PHA02517 40041000720 HTH-like domain; Region: HTH_21; pfam13276 40041000721 Integrase core domain; Region: rve; pfam00665 40041000722 Integrase core domain; Region: rve_2; pfam13333 40041000723 HMMPfam hit to PF00665, Integrase, catalytic core, score 7.9e-38 40041000724 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 40041000725 Helix-turn-helix domain; Region: HTH_28; pfam13518 40041000726 HMMPfam hit to PF01527, Transposase IS3/IS911, score 0.0011 40041000727 Predicted helix-turn-helix motif with score 1140.000, SD 3.07 at aa 19-40, sequence KSIKCLSEKFSIAESDLKYMIR 40041000728 Ortholog of S. equi 4047 (FM204883) SEQ0213; CDS contain a nonsense mutation (opal) after codon 7 40041000729 HMMPfam hit to PF00293, NUDIX hydrolase, core, score 4.4e-18 40041000730 Transposase [DNA replication, recombination, and repair]; Region: COG5421 40041000731 Transposase [DNA replication, recombination, and repair]; Region: COG5421 40041000732 Predicted membrane protein [Function unknown]; Region: COG4640 40041000733 1 probable transmembrane helix predicted for SZO01330 by TMHMM2.0 at aa 13-32 40041000734 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 40041000735 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 40041000736 active site 40041000737 HMMPfam hit to PF00849, Pseudouridine synthase, score 1e-45 40041000738 PS01129 Rlu family of pseudouridine synthase signature. 40041000739 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 40041000740 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 40041000741 homotrimer interaction site [polypeptide binding]; other site 40041000742 putative active site [active] 40041000743 HMMPfam hit to PF01042, Endoribonuclease L-PSP, score 0.0016 40041000744 Membrane carboxypeptidase (penicillin-binding protein) [Cell envelope biogenesis, outer membrane]; Region: MrcB; COG0744 40041000745 Transglycosylase; Region: Transgly; pfam00912 40041000746 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 40041000747 1 probable transmembrane helix predicted for SZO01380 by TMHMM2.0 at aa 100-122 40041000748 HMMPfam hit to PF00912, Glycosyl transferase, family 51, score 3.1e-80 40041000749 PS00017 ATP/GTP-binding site motif A (P-loop). 40041000750 HMMPfam hit to PF00905, Penicillin-binding protein, transpeptidase, score 4e-45 40041000751 PS00017 ATP/GTP-binding site motif A (P-loop). 40041000752 50S ribosomal protein L33; Validated; Region: rpmG; PRK00504 40041000753 HMMPfam hit to PF00471, Ribosomal protein L33, score 5.2e-12 40041000754 Preprotein translocase subunit SecE [Intracellular trafficking and secretion]; Region: SecE; COG0690 40041000755 1 probable transmembrane helix predicted for SZO01400 by TMHMM2.0 at aa 26-48 40041000756 transcription antitermination protein NusG; Validated; Region: nusG; PRK05609 40041000757 Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891 40041000758 putative homodimer interface [polypeptide binding]; other site 40041000759 NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091 40041000760 heterodimer interface [polypeptide binding]; other site 40041000761 homodimer interface [polypeptide binding]; other site 40041000762 HMMPfam hit to PF02357, Transcription antitermination protein, NusG, N-terminal, score 8.1e-52 40041000763 HMMPfam hit to PF00467, KOW, score 1.4e-07 40041000764 M protein trans-acting positive regulator (MGA) HTH domain; Region: HTH_Mga; pfam08280 40041000765 Mga helix-turn-helix domain; Region: Mga; pfam05043 40041000766 M protein trans-acting positive regulator (MGA) PRD domain; Region: PRD_Mga; pfam08270 40041000767 HMMPfam hit to PF08280, Helix-turn-helix Mga, DNA-binding trans-acting positive regulator, score 2.2e-14 40041000768 HMMPfam hit to PF05043, M trans-acting positive regulator, score 3.2e-29 40041000769 Predicted helix-turn-helix motif with score 1528.000, SD 4.39 at aa 103-124, sequence ASLDDLAEALFISLSTLKRLIR 40041000770 HMMPfam hit to PF08270, Mga DNA-binding trans-acting positive regulator, PRD region, score 8.3e-38 40041000771 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 40041000772 HMMPfam hit to PF00746, Surface protein from Gram-positive cocci, anchor region, score 2.3e-09 40041000773 PS00343 Gram-positive cocci surface proteins 'anchoring' hexapeptide. 40041000774 1 probable transmembrane helix predicted for SZO01430 by TMHMM2.0 at aa 383-405 40041000775 leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390 40041000776 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 40041000777 HIGH motif; other site 40041000778 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 40041000779 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 40041000780 active site 40041000781 KMSKS motif; other site 40041000782 Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958 40041000783 tRNA binding surface [nucleotide binding]; other site 40041000784 HMMPfam hit to PF09334, Aminoacyl-tRNA synthetase, class I (M), score 1.3e-10 40041000785 PS00178 Aminoacyl-transfer RNA synthetases class-I signature. 40041000786 HMMPfam hit to PF08264, Valyl/Leucyl/Isoleucyl-tRNA synthetase, class I, anticodon-binding, score 3.6e-08 40041000787 PTS system ascorbate-specific transporter subunit IIC; Reviewed; Region: PRK12997 40041000788 HMMPfam hit to PF04215, sugar-specific permease, SgaT/UlaA, score 3.9e-255 40041000789 11 probable transmembrane helices predicted for SZO01460 by TMHMM2.0 at aa 15-34, 41-63, 101-123, 132-154, 160-177, 238-257, 277-296, 339-361, 365-384, 397-419 and 434-456 40041000790 PTS_IIB_ascorbate: subunit IIB of enzyme II (EII) of the L-ascorbate-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is an L-ascorbate-specific permease with two cytoplasmic subunits (IIA and IIB) and a...; Region: PTS_IIB_ascorbate; cd05563 40041000791 active site 40041000792 P-loop; other site 40041000793 phosphorylation site [posttranslational modification] 40041000794 HMMPfam hit to PF02302, Phosphotransferase system, lactose/cellobiose-specific IIB subunit, score 1.1e-25 40041000795 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 40041000796 active site 40041000797 phosphorylation site [posttranslational modification] 40041000798 HMMPfam hit to PF00359, Phosphotransferase system, phosphoenolpyruvate-dependent sugar EIIA 2, score 2.2e-34 40041000799 3-Keto-L-gulonate 6-phosphate decarboxylase (KGPDC) and D-arabino-3-hexulose-6-phosphate synthase (HPS). KGPDC catalyzes the formation of L-xylulose 5-phosphate and carbon dioxide from 3-keto-L-gulonate 6-phosphate as part of the anaerobic pathway for...; Region: KGPDC_HPS; cd04726 40041000800 active site 40041000801 dimer interface [polypeptide binding]; other site 40041000802 magnesium binding site [ion binding]; other site 40041000803 HMMPfam hit to PF00215, Orotidine 5'-phosphate decarboxylase, core, score 9.9e-55 40041000804 putative L-xylulose 5-phosphate 3-epimerase; Reviewed; Region: PRK13210 40041000805 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cd00019 40041000806 AP (apurinic/apyrimidinic) site pocket; other site 40041000807 DNA interaction; other site 40041000808 Metal-binding active site; metal-binding site 40041000809 HMMPfam hit to PF01261, Xylose isomerase-type TIM barrel, score 2.3e-46 40041000810 L-ribulose-5-phosphate 4-epimerase; Provisional; Region: araD; PRK13145 40041000811 L-ribulose-5-phosphate 4-epimerase; Reviewed; Region: araD; PRK08193 40041000812 intersubunit interface [polypeptide binding]; other site 40041000813 active site 40041000814 Zn2+ binding site [ion binding]; other site 40041000815 HMMPfam hit to PF00596, Class II aldolase/adducin, N-terminal, score 9.2e-98 40041000816 PS00017 ATP/GTP-binding site motif A (P-loop). 40041000817 Transcriptional antiterminator [Transcription]; Region: BglG; COG3711 40041000818 PRD domain; Region: PRD; pfam00874 40041000819 PRD domain; Region: PRD; pfam00874 40041000820 PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568 40041000821 active site 40041000822 P-loop; other site 40041000823 phosphorylation site [posttranslational modification] 40041000824 HMMPfam hit to PF08279, Helix-turn-helix, type 11, score 0.0011 40041000825 HMMPfam hit to PF00874, PRD, score 1.3e-14 40041000826 HMMPfam hit to PF00874, PRD, score 2.7e-14 40041000827 putative L-ascorbate 6-phosphate lactonase; Provisional; Region: PRK11709 40041000828 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 40041000829 ABC-type proline/glycine betaine transport system, ATPase component [Amino acid transport and metabolism]; Region: ProV; COG4175 40041000830 ATP-binding cassette domain of the osmoprotectant proline/glycine betaine uptake system; Region: ABC_Pro_Gly_Betaine; cd03294 40041000831 Walker A/P-loop; other site 40041000832 ATP binding site [chemical binding]; other site 40041000833 Q-loop/lid; other site 40041000834 ABC transporter signature motif; other site 40041000835 Walker B; other site 40041000836 D-loop; other site 40041000837 H-loop/switch region; other site 40041000838 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 40041000839 HMMPfam hit to PF00005, ABC transporter related, score 2.5e-64 40041000840 PS00017 ATP/GTP-binding site motif A (P-loop). 40041000841 PS00211 ABC transporters family signature. 40041000842 HMMPfam hit to PF00571, Cystathionine beta-synthase, core, score 2.2e-13 40041000843 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 40041000844 dimer interface [polypeptide binding]; other site 40041000845 conserved gate region; other site 40041000846 putative PBP binding loops; other site 40041000847 ABC-ATPase subunit interface; other site 40041000848 ABC-type proline/glycine betaine transport systems, periplasmic components [Amino acid transport and metabolism]; Region: ProX; COG2113 40041000849 Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069 40041000850 7 probable transmembrane helices predicted for SZO01550 by TMHMM2.0 at aa 48-67, 72-91, 98-120, 143-165, 215-237, 252-269 and 292-314 40041000851 HMMPfam hit to PF00528, Binding-protein-dependent transport systems inner membrane component, score 3e-31 40041000852 PS00402 Binding-protein-dependent transport systems inner membrane comp. sign. 40041000853 HMMPfam hit to PF04069, Substrate-binding region of ABC-type glycine betaine transport system, score 3e-93 40041000854 DNA polymerase I; Provisional; Region: PRK05755 40041000855 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 40041000856 active site 40041000857 metal binding site 1 [ion binding]; metal-binding site 40041000858 putative 5' ssDNA interaction site; other site 40041000859 metal binding site 3; metal-binding site 40041000860 metal binding site 2 [ion binding]; metal-binding site 40041000861 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 40041000862 putative DNA binding site [nucleotide binding]; other site 40041000863 putative metal binding site [ion binding]; other site 40041000864 inactive DEDDy 3'-5' exonuclease domain of Bacillus stearothermophilus DNA polymerase I and similar family-A DNA polymerases; Region: DNA_polA_I_Bacillus_like_exo; cd06140 40041000865 Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637 40041000866 active site 40041000867 DNA binding site [nucleotide binding] 40041000868 catalytic site [active] 40041000869 HMMPfam hit to PF02739, 5'-3' exonuclease, score 1.7e-93 40041000870 HMMPfam hit to PF01367, 5'-3' exonuclease, score 4.6e-57 40041000871 HMMPfam hit to PF01612, 3'-5' exonuclease, score 0.0094 40041000872 HMMPfam hit to PF00476, DNA-directed DNA polymerase, score 7.1e-212 40041000873 PS00447 DNA polymerase family A signature. 40041000874 Predicted CoA-binding protein [General function prediction only]; Region: COG1832 40041000875 HMMPfam hit to PF02629, CoA-binding, score 4.9e-11 40041000876 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 40041000877 metal binding site 2 [ion binding]; metal-binding site 40041000878 putative DNA binding helix; other site 40041000879 metal binding site 1 [ion binding]; metal-binding site 40041000880 dimer interface [polypeptide binding]; other site 40041000881 structural Zn2+ binding site [ion binding]; other site 40041000882 HMMPfam hit to PF01475, Ferric-uptake regulator, score 1.6e-50 40041000883 Gram positive anchor; Region: Gram_pos_anchor; pfam00746 40041000884 PS00017 ATP/GTP-binding site motif A (P-loop). 40041000885 HMMPfam hit to PF07554, Uncharacterised sugar-binding, score 5.2e-07 40041000886 HMMPfam hit to PF00746, Surface protein from Gram-positive cocci, anchor region, score 1.8e-07 40041000887 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 40041000888 YSIRK type signal peptide; Region: YSIRK_signal; cl04650 40041000889 NPCBM/NEW2 domain; Region: NPCBM; pfam08305 40041000890 F5/8 type C domain; Region: F5_F8_type_C; pfam00754 40041000891 HMMPfam hit to PF04650, YSIRK Gram-positive signal peptide, score 2.6e-05 40041000892 1 probable transmembrane helix predicted for SZO01600 by TMHMM2.0 at aa 21-40 40041000893 HMMPfam hit to PF08305, Glycosyl hydrolase family 98, carbohydrate-binding module, score 3.8e-17 40041000894 HMMPfam hit to PF02012, Glycoside hydrolase, BNR repeat, score 0.64 40041000895 HMMPfam hit to PF02012, Glycoside hydrolase, BNR repeat, score 2.4 40041000896 HMMPfam hit to PF00754, Coagulation factor 5/8 type, C-terminal, score 7.8e-14 40041000897 PS00017 ATP/GTP-binding site motif A (P-loop). 40041000898 Protein of unknown function (DUF975); Region: DUF975; pfam06161 40041000899 HMMPfam hit to PF06161, Protein of unknown function DUF975, score 3.1e-80 40041000900 6 probable transmembrane helices predicted for SZO01610 by TMHMM2.0 at aa 21-43, 53-75, 88-110, 115-137, 144-166 and 219-241 40041000901 queuine tRNA-ribosyltransferase; Provisional; Region: tgt; PRK00112 40041000902 Queuine/archaeosine tRNA-ribosyltransferase [Translation, ribosomal structure and biogenesis]; Region: Tgt; COG0343 40041000903 HMMPfam hit to PF01702, Queuine/other tRNA-ribosyltransferase, score 3.4e-144 40041000904 Collagen triple helix repeat (20 copies); Region: Collagen; pfam01391 40041000905 Gram positive anchor; Region: Gram_pos_anchor; pfam00746 40041000906 1 probable transmembrane helix predicted for SZO01630 by TMHMM2.0 at aa 13-35 40041000907 HMMPfam hit to PF01391, Collagen triple helix repeat, score 2.9e-12 40041000908 HMMPfam hit to PF01391, Collagen triple helix repeat, score 3.3e-14 40041000909 HMMPfam hit to PF01391, Collagen triple helix repeat, score 2.6e-13 40041000910 HMMPfam hit to PF00746, Surface protein from Gram-positive cocci, anchor region, score 5.5e-12 40041000911 PS00343 Gram-positive cocci surface proteins 'anchoring' hexapeptide. 40041000912 Zinc finger domain containing protein (CHY type) [Function unknown]; Region: COG4357 40041000913 CHY zinc finger; Region: zf-CHY; pfam05495 40041000914 HMMPfam hit to PF05495, Zinc finger, CHY-type, score 2.3e-25 40041000915 PS00190 Cytochrome c family heme-binding site signature. 40041000916 Uncharacterized conserved protein [General function prediction only]; Region: BioY; COG1268 40041000917 5 probable transmembrane helices predicted for SZO01650 by TMHMM2.0 at aa 15-37, 49-71, 86-108, 115-137 and 147-169 40041000918 HMMPfam hit to PF02632, BioY protein, score 3e-18 40041000919 Metal-dependent hydrolases of the beta-lactamase superfamily III [General function prediction only]; Region: ElaC; COG1234 40041000920 HMMPfam hit to PF00753, Beta-lactamase-like, score 2e-19 40041000921 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 40041000922 nucleoside/Zn binding site; other site 40041000923 dimer interface [polypeptide binding]; other site 40041000924 catalytic motif [active] 40041000925 HMMPfam hit to PF00383, CMP/dCMP deaminase, zinc-binding, score 1.5e-33 40041000926 PS00903 Cytidine and deoxycytidylate deaminases zinc-binding region signature. 40041000927 PS00041 Bacterial regulatory proteins, araC family signature. 40041000928 Uncharacterized protein involved in cytokinesis, contains TGc (transglutaminase/protease-like) domain [Cell division and chromosome partitioning]; Region: CYK3; COG5279 40041000929 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 40041000930 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 40041000931 1 probable transmembrane helix predicted for SZO01690 by TMHMM2.0 at aa 13-35 40041000932 Glycosyltransferases, probably involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: COG1215 40041000933 CESA_like is the cellulose synthase superfamily; Region: CESA_like; cd06423 40041000934 Glycosyl transferase family group 2; Region: Glyco_trans_2_3; pfam13632 40041000935 DXD motif; other site 40041000936 5 probable transmembrane helices predicted for SZO01700 by TMHMM2.0 at aa 7-29, 33-55, 319-341, 351-370 and 377-394 40041000937 HMMPfam hit to PF00535, Glycosyl transferase, family 2, score 2.9e-33 40041000938 UDP-glucose 6-dehydrogenase; Provisional; Region: PRK15057 40041000939 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 40041000940 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 40041000941 UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984 40041000942 HMMPfam hit to PF03721, UDP-glucose/GDP-mannose dehydrogenase, N-terminal, score 5.6e-58 40041000943 HMMPfam hit to PF00984, UDP-glucose/GDP-mannose dehydrogenase, dimerisation, score 1.6e-36 40041000944 HMMPfam hit to PF03720, UDP-glucose/GDP-mannose dehydrogenase, C-terminal, score 6.7e-06 40041000945 Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541 40041000946 dTDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: RfbA; COG1209 40041000947 active site 40041000948 tetramer interface; other site 40041000949 HMMPfam hit to PF00483, Nucleotidyl transferase, score 1.2e-19 40041000950 bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase; Provisional; Region: glmU; PRK14354 40041000951 N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540 40041000952 Substrate binding site; other site 40041000953 Mg++ binding site; other site 40041000954 N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353 40041000955 active site 40041000956 substrate binding site [chemical binding]; other site 40041000957 CoA binding site [chemical binding]; other site 40041000958 HMMPfam hit to PF01128, 4-diphosphocytidyl-2C-methyl-D-erythritol synthase, score 2.7e-06 40041000959 HMMPfam hit to PF00132, Bacterial transferase hexapeptide repeat, score 4.3 40041000960 HMMPfam hit to PF00132, Bacterial transferase hexapeptide repeat, score 9.7 40041000961 HMMPfam hit to PF00132, Bacterial transferase hexapeptide repeat, score 0.75 40041000962 HMMPfam hit to PF00132, Bacterial transferase hexapeptide repeat, score 39 40041000963 HMMPfam hit to PF00132, Bacterial transferase hexapeptide repeat, score 36 40041000964 HMMPfam hit to PF00132, Bacterial transferase hexapeptide repeat, score 1.2 40041000965 HMMPfam hit to PF00132, Bacterial transferase hexapeptide repeat, score 14 40041000966 glucose-6-phosphate isomerase; Provisional; Region: pgi; PRK14097 40041000967 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015 40041000968 active site 40041000969 dimer interface [polypeptide binding]; other site 40041000970 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016 40041000971 dimer interface [polypeptide binding]; other site 40041000972 active site 40041000973 HMMPfam hit to PF00342, Phosphoglucose isomerase (PGI), score 8.4e-154 40041000974 PS00765 Phosphoglucose isomerase signature 1. 40041000975 sorbitol-6-phosphate 2-dehydrogenase; Provisional; Region: PRK06171 40041000976 classical (c) SDRs; Region: SDR_c; cd05233 40041000977 NAD(P) binding site [chemical binding]; other site 40041000978 active site 40041000979 HMMPfam hit to PF00106, Short-chain dehydrogenase/reductase SDR, score 5.6e-24 40041000980 PS00061 Short-chain dehydrogenases/reductases family signature. 40041000981 PS00639 Eukaryotic thiol (cysteine) proteases histidine active site. 40041000982 Transcriptional antiterminator [Transcription]; Region: BglG; COG3711 40041000983 HTH domain; Region: HTH_11; pfam08279 40041000984 PRD domain; Region: PRD; pfam00874 40041000985 PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568 40041000986 active site 40041000987 P-loop; other site 40041000988 phosphorylation site [posttranslational modification] 40041000989 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 40041000990 active site 40041000991 phosphorylation site [posttranslational modification] 40041000992 HMMPfam hit to PF08279, Helix-turn-helix, type 11, score 1e-09 40041000993 Predicted helix-turn-helix motif with score 1780.000, SD 5.25 at aa 86-107, sequence LVIDDLADEIGVSRSTINKDLK 40041000994 HMMPfam hit to PF00874, PRD, score 1.1e-12 40041000995 Glucitol operon activator protein (GutM); Region: GutM; pfam06923 40041000996 HMMPfam hit to PF06923, Glucitol operon activator, score 3.3e-67 40041000997 1 probable transmembrane helix predicted for SZO01770 by TMHMM2.0 at aa 4-23 40041000998 PTS system enzyme II sorbitol-specific factor; Region: EII-GUT; pfam03608 40041000999 HMMPfam hit to PF03608, Phosphotransferase system, enzyme II sorbitol-specific factor, score 6.4e-135 40041001000 3 probable transmembrane helices predicted for SZO01780 by TMHMM2.0 at aa 25-47, 68-90 and 141-160 40041001001 Sorbitol phosphotransferase enzyme II N-terminus; Region: EIIBC-GUT_N; pfam03612 40041001002 PTS system, glucitol/sorbitol-specific, IIBC component; Region: EIIBC-GUT; TIGR00825 40041001003 Sorbitol phosphotransferase enzyme II C-terminus; Region: EIIBC-GUT_C; pfam07663 40041001004 HMMPfam hit to PF03612, Sorbitol phosphotransferase enzyme II, N-terminal, score 2.9e-109 40041001005 2 probable transmembrane helices predicted for SZO01790 by TMHMM2.0 at aa 184-206 and 221-243 40041001006 HMMPfam hit to PF07663, Sorbitol phosphotransferase enzyme II, C-terminal, score 2e-51 40041001007 PTS system glucitol/sorbitol-specific IIA component; Region: PTSIIA_gutA; pfam03829 40041001008 HMMPfam hit to PF03829, Phosphotransferase system, glucitol/sorbitol-specific IIA component, score 1e-56 40041001009 Probable gene remnant. CDS is truncated by the insertion of the an integrative conjugative element and subsequent recombination events. N-terminal region of complete CDS is SZO18031 40041001010 1 probable transmembrane helix predicted for SZO01810 by TMHMM2.0 at aa 15-34 40041001011 Streptococcal histidine triad protein; Region: Strep_his_triad; pfam04270 40041001012 HMMPfam hit to PF04270, Streptococcal histidine triad, score 0.0066 40041001013 HMMPfam hit to PF04270, Streptococcal histidine triad, score 3.5e-06 40041001014 HMMPfam hit to PF04270, Streptococcal histidine triad, score 21 40041001015 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 40041001016 Ribosomal protein L11 methyltransferase (PrmA); Region: PrmA; pfam06325 40041001017 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 40041001018 S-adenosylmethionine binding site [chemical binding]; other site 40041001019 HMMPfam hit to PF06325, Ribosomal L11 methyltransferase, score 1.5e-157 40041001020 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1385 40041001021 RNA methyltransferase, RsmE family; Region: TIGR00046 40041001022 HMMPfam hit to PF04452, Protein of unknown function DUF558, methyltransferase predicted, score 3.3e-89 40041001023 Transcriptional regulators [Transcription]; Region: PurR; COG1609 40041001024 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 40041001025 DNA binding site [nucleotide binding] 40041001026 domain linker motif; other site 40041001027 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 40041001028 HMMPfam hit to PF00356, Bacterial regulatory protein, LacI, score 2.1e-11 40041001029 Predicted helix-turn-helix motif with score 2421.000, SD 7.43 at aa 2-23, sequence VTIKDVARLAGVSPSTASRAIN 40041001030 PS00356 Bacterial regulatory proteins, lacI family signature. 40041001031 HMMPfam hit to PF00532, Periplasmic binding protein/LacI transcriptional regulator, score 0.00015 40041001032 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 40041001033 PTS system, IIBC component; Region: PTS-II-BC-unk1; TIGR02003 40041001034 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 40041001035 active site turn [active] 40041001036 phosphorylation site [posttranslational modification] 40041001037 Phosphotransferase system IIA components [Carbohydrate transport and metabolism]; Region: NagE; COG2190 40041001038 HPr interaction site; other site 40041001039 glycerol kinase (GK) interaction site [polypeptide binding]; other site 40041001040 active site 40041001041 phosphorylation site [posttranslational modification] 40041001042 HMMPfam hit to PF02378, Phosphotransferase system, EIIC, score 1.4e-44 40041001043 9 probable transmembrane helices predicted for SZO01860 by TMHMM2.0 at aa 20-42, 57-79, 86-108, 141-163, 184-206, 312-329, 341-358, 363-385 and 418-440 40041001044 HMMPfam hit to PF00367, Phosphotransferase system, EIIB, score 3.8e-16 40041001045 PS01035 PTS EIIB domains cysteine phosphorylation site signature. 40041001046 HMMPfam hit to PF00358, Phosphotransferase system, sugar-specific permease EIIA 1 domain, score 3.4e-54 40041001047 PS00371 PTS EIIA domains phosphorylation site signature 1. 40041001048 Streptococcus agalactiae RgfB, part of a putative two component signal transduction system, and related proteins; Region: RgfB-like; cd09079 40041001049 putative catalytic site [active] 40041001050 putative metal binding site [ion binding]; other site 40041001051 putative phosphate binding site [ion binding]; other site 40041001052 HMMPfam hit to PF03372, Endonuclease/exonuclease/phosphatase, score 2.6e-13 40041001053 flavoprotein NrdI; Provisional; Region: PRK02551 40041001054 HMMPfam hit to PF07972, Ribonucleotide reductase Class Ib, NrdI, score 5.5e-69 40041001055 PS00639 Eukaryotic thiol (cysteine) proteases histidine active site. 40041001056 Ortholog of S. equi 4047 (FM204883) SEQ2018; CDS contains a frameshift after codon 225. Frameshift occurs at a poly A heptamer 40041001057 HMMPfam hit to PF00165, Helix-turn-helix, AraC type, score 1.1e-07 40041001058 Predicted helix-turn-helix motif with score 2064.000, SD 6.22 at aa 309-330, sequence VTTAELAQHFNMSESKLRQIFK 40041001059 Gram positive anchor; Region: Gram_pos_anchor; pfam00746 40041001060 HMMPfam hit to PF04650, YSIRK Gram-positive signal peptide, score 2.9e-12 40041001061 HMMPfam hit to PF00746, Surface protein from Gram-positive cocci, anchor region, score 5.3e-12 40041001062 PS00343 Gram-positive cocci surface proteins 'anchoring' hexapeptide. 40041001063 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 40041001064 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 40041001065 Zn2+ binding site [ion binding]; other site 40041001066 Mg2+ binding site [ion binding]; other site 40041001067 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 40041001068 synthetase active site [active] 40041001069 NTP binding site [chemical binding]; other site 40041001070 metal binding site [ion binding]; metal-binding site 40041001071 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 40041001072 ACT domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876 40041001073 HMMPfam hit to PF01966, Metal-dependent phosphohydrolase, HD region, subdomain, score 7.5e-14 40041001074 HMMPfam hit to PF04607, RelA/SpoT, score 3.4e-47 40041001075 HMMPfam hit to PF02824, TGS, score 1.2e-28 40041001076 HMMPfam hit to PF01842, Amino acid-binding ACT, score 8.2e-05 40041001077 D-Tyrosyl-tRNAtyr deacylases; a class of tRNA-dependent hydrolases which are capable of hydrolyzing the ester bond of D-Tyrosyl-tRNA reducing the level of cellular D-Tyrosine while recycling the peptidyl-tRNA; found in bacteria and in eukaryotes but not...; Region: Dtyr_deacylase; cd00563 40041001078 putative active site [active] 40041001079 dimerization interface [polypeptide binding]; other site 40041001080 putative tRNAtyr binding site [nucleotide binding]; other site 40041001081 HMMPfam hit to PF02580, D-tyrosyl-tRNA(Tyr) deacylase, score 1.6e-94 40041001082 Staphylokinase/Streptokinase family; Region: Staphylokinase; pfam02821 40041001083 HMMPfam hit to PF02821, Staphylokinase/Streptokinase, score 4.5e-10 40041001084 Regulator of polyketide synthase expression [Signal transduction mechanisms / Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2508 40041001085 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 40041001086 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 40041001087 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 40041001088 Walker A/P-loop; other site 40041001089 ATP binding site [chemical binding]; other site 40041001090 Q-loop/lid; other site 40041001091 ABC transporter signature motif; other site 40041001092 Walker B; other site 40041001093 D-loop; other site 40041001094 H-loop/switch region; other site 40041001095 TOBE domain; Region: TOBE; pfam03459 40041001096 HMMPfam hit to PF00005, ABC transporter related, score 5.4e-57 40041001097 PS00017 ATP/GTP-binding site motif A (P-loop). 40041001098 PS00211 ABC transporters family signature. 40041001099 HMMPfam hit to PF08402, Transport-associated OB, type 2, score 2.4e-10 40041001100 alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403 40041001101 Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333 40041001102 Ca binding site [ion binding]; other site 40041001103 active site 40041001104 catalytic site [active] 40041001105 HMMPfam hit to PF00128, Glycosyl hydrolase, family 13, catalytic region, score 1.4e-139 40041001106 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 40041001107 catalytic residues [active] 40041001108 preprotein translocase subunit YajC; Validated; Region: yajC; PRK06531 40041001109 HMMPfam hit to PF02699, YajC, score 2.8e-09 40041001110 1 probable transmembrane helix predicted for SZO01980 by TMHMM2.0 at aa 5-19 40041001111 Undecaprenyl pyrophosphate synthase [Lipid metabolism]; Region: UppS; COG0020 40041001112 Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cd00475 40041001113 catalytic residue [active] 40041001114 putative FPP diphosphate binding site; other site 40041001115 putative FPP binding hydrophobic cleft; other site 40041001116 dimer interface [polypeptide binding]; other site 40041001117 putative IPP diphosphate binding site; other site 40041001118 HMMPfam hit to PF01255, Di-trans-poly-cis-decaprenylcistransferase, score 6.5e-109 40041001119 PS01066 Undecaprenyl pyrophosphate synthetase family signature. 40041001120 CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575 40041001121 Cytidylyltransferase family; Region: CTP_transf_1; pfam01148 40041001122 HMMPfam hit to PF01148, Phosphatidate cytidylyltransferase, score 1.3e-96 40041001123 7 probable transmembrane helices predicted for SZO02000 by TMHMM2.0 at aa 7-29, 49-68, 80-97, 107-126, 135-157, 172-191 and 196-218 40041001124 PS01315 Phosphatidate cytidylyltransferase signature. 40041001125 RIP metalloprotease RseP; Region: TIGR00054 40041001126 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 40041001127 active site 40041001128 Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020 40041001129 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 40041001130 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 40041001131 putative substrate binding region [chemical binding]; other site 40041001132 5 probable transmembrane helices predicted for SZO02010 by TMHMM2.0 at aa 4-26, 169-191, 302-324, 345-367 and 394-413 40041001133 HMMPfam hit to PF02163, Peptidase M50, score 6.2e-96 40041001134 PS00142 Neutral zinc metallopeptidases, zinc-binding region signature. 40041001135 HMMPfam hit to PF00595, PDZ/DHR/GLGF, score 3.8e-06 40041001136 prolyl-tRNA synthetase; Provisional; Region: PRK09194 40041001137 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 40041001138 motif 1; other site 40041001139 dimer interface [polypeptide binding]; other site 40041001140 active site 40041001141 motif 2; other site 40041001142 INS is an amino acid-editing domain inserted (INS) into the bacterial class II prolyl-tRNA synthetase (ProRS) however, this CD is not exclusively bacterial. It is also found at the N-terminus of the eukaryotic/archaea-like ProRS's of yeasts and...; Region: ProRS-INS; cd04334 40041001143 putative deacylase active site [active] 40041001144 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 40041001145 active site 40041001146 motif 3; other site 40041001147 ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding; Region: ProRS_anticodon_short; cd00861 40041001148 anticodon binding site; other site 40041001149 HMMPfam hit to PF00587, Aminoacyl-tRNA synthetase, class II (G, H, P and S), score 2.1e-47 40041001150 PS00179 Aminoacyl-transfer RNA synthetases class-II signature 1. 40041001151 HMMPfam hit to PF04073, YbaK/prolyl-tRNA synthetase associated region, score 8.4e-32 40041001152 HMMPfam hit to PF03129, Anticodon-binding, score 4.9e-19 40041001153 Bacterial protein of unknown function (DUF925); Region: DUF925; pfam06042 40041001154 HMMPfam hit to PF06042, Protein of unknown function DUF925, bacterial, score 4.3e-77 40041001155 DNA polymerase III PolC; Validated; Region: polC; PRK00448 40041001156 DNA polymerase III polC-type N-terminus; Region: DNA_pol3_alph_N; pfam11490 40041001157 polC_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold nucleic acid binding domain of Bacillus subtilis type C replicative DNA polymerase III alpha subunit (polC). Replication in B. subtilis and Staphylococcus aureus requires two...; Region: polC_OBF; cd04484 40041001158 generic binding surface II; other site 40041001159 generic binding surface I; other site 40041001160 Polymerase and Histidinol Phosphatase domain; Region: PHP; cl17102 40041001161 active site 40041001162 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 40041001163 active site 40041001164 catalytic site [active] 40041001165 substrate binding site [chemical binding]; other site 40041001166 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III at PolC gene; Region: PHP_PolIIIA_POLC; cd07435 40041001167 HMMPfam hit to PF01336, Nucleic acid binding, OB-fold, tRNA/helicase-type, score 3.6e-06 40041001168 HMMPfam hit to PF02811, PHP, C-terminal, score 1e-32 40041001169 HMMPfam hit to PF00929, Exonuclease, RNase T and DNA polymerase III, score 1.2e-41 40041001170 HMMPfam hit to PF07733, Bacterial DNA polymerase III, alpha subunit, score 3.9e-191 40041001171 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 40041001172 MarR family; Region: MarR; pfam01047 40041001173 HMMPfam hit to PF01047, Bacterial regulatory protein, MarR, score 2.1e-22 40041001174 Predicted flavoprotein [General function prediction only]; Region: COG0431 40041001175 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 40041001176 HMMPfam hit to PF03358, NADPH-dependent FMN reductase, score 2.1e-24 40041001177 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 40041001178 active site 40041001179 catalytic residues [active] 40041001180 metal binding site [ion binding]; metal-binding site 40041001181 HMMPfam hit to PF01327, Formylmethionine deformylase, score 2.1e-86 40041001182 Fibronectin-binding protein signal sequence; Region: Fb_signal; pfam08341 40041001183 TQXA domain; Region: TQXA_dom; TIGR03934 40041001184 Fibronectin binding repeat; Region: Fn_bind; pfam02986 40041001185 Fibronectin binding repeat; Region: Fn_bind; pfam02986 40041001186 Fibronectin binding repeat; Region: Fn_bind; pfam02986 40041001187 2 probable transmembrane helices predicted for SZO02080 by TMHMM2.0 at aa 13-35 and 459-478 40041001188 HMMPfam hit to PF08341, Fibronectin-binding, signal sequence, score 7.6e-27 40041001189 HMMPfam hit to PF02986, Fibronectin binding repeat, score 0.0044 40041001190 HMMPfam hit to PF02986, Fibronectin binding repeat, score 2.9e-13 40041001191 HMMPfam hit to PF02986, Fibronectin binding repeat, score 2.2e-15 40041001192 HMMPfam hit to PF02986, Fibronectin binding repeat, score 1.1e-15 40041001193 Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353 40041001194 16S/18S rRNA binding site [nucleotide binding]; other site 40041001195 S13e-L30e interaction site [polypeptide binding]; other site 40041001196 25S rRNA binding site [nucleotide binding]; other site 40041001197 HMMPfam hit to PF00312, Ribosomal protein S15, score 5.7e-35 40041001198 putative transposase OrfB; Reviewed; Region: PHA02517 40041001199 HTH-like domain; Region: HTH_21; pfam13276 40041001200 Integrase core domain; Region: rve; pfam00665 40041001201 Integrase core domain; Region: rve_2; pfam13333 40041001202 HMMPfam hit to PF00665, Integrase, catalytic core, score 3e-39 40041001203 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 40041001204 Transposase; Region: HTH_Tnp_1; cl17663 40041001205 HMMPfam hit to PF01527, Transposase IS3/IS911, score 0.00045 40041001206 polynucleotide phosphorylase/polyadenylase; Provisional; Region: PRK11824 40041001207 Polyribonucleotide nucleotidyltransferase, repeat 1; Region: RNase_PH_PNPase_1; cd11363 40041001208 RNase E interface [polypeptide binding]; other site 40041001209 trimer interface [polypeptide binding]; other site 40041001210 Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364 40041001211 RNase E interface [polypeptide binding]; other site 40041001212 trimer interface [polypeptide binding]; other site 40041001213 active site 40041001214 Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393 40041001215 S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472 40041001216 RNA binding site [nucleotide binding]; other site 40041001217 HMMPfam hit to PF01138, Exoribonuclease, phosphorolytic domain 1, score 3.4e-28 40041001218 HMMPfam hit to PF03725, Exoribonuclease, phosphorolytic domain 2, score 3.4e-14 40041001219 HMMPfam hit to PF03726, Polynucleotide phosphorylase, phosphorolytic RNA-binding, bacterial/organelle-type, score 6.5e-10 40041001220 HMMPfam hit to PF01138, Exoribonuclease, phosphorolytic domain 1, score 2e-41 40041001221 HMMPfam hit to PF03725, Exoribonuclease, phosphorolytic domain 2, score 2.5e-25 40041001222 HMMPfam hit to PF00013, K Homology, type 1, score 2e-15 40041001223 HMMPfam hit to PF00575, S1, RNA binding, score 3.5e-22 40041001224 Serine acetyltransferase [Amino acid transport and metabolism]; Region: CysE; COG1045 40041001225 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354 40041001226 trimer interface [polypeptide binding]; other site 40041001227 active site 40041001228 substrate binding site [chemical binding]; other site 40041001229 CoA binding site [chemical binding]; other site 40041001230 HMMPfam hit to PF00132, Bacterial transferase hexapeptide repeat, score 9.1 40041001231 HMMPfam hit to PF00132, Bacterial transferase hexapeptide repeat, score 3.7 40041001232 HMMPfam hit to PF00132, Bacterial transferase hexapeptide repeat, score 11 40041001233 PS00017 ATP/GTP-binding site motif A (P-loop). 40041001234 cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260 40041001235 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 40041001236 active site 40041001237 HIGH motif; other site 40041001238 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 40041001239 KMSKS motif; other site 40041001240 Anticodon-binding domain of cysteinyl tRNA synthetases; Region: Anticodon_Ia_Cys; cd07963 40041001241 tRNA binding surface [nucleotide binding]; other site 40041001242 anticodon binding site; other site 40041001243 HMMPfam hit to PF01406, Cysteinyl-tRNA synthetase, class Ia, N-terminal, score 2.4e-188 40041001244 HMMPfam hit to PF09190, Cysteinyl-tRNA synthetase, class Ia, DALR, score 1.4e-18 40041001245 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 40041001246 active site 40041001247 metal binding site [ion binding]; metal-binding site 40041001248 dimerization interface [polypeptide binding]; other site 40041001249 1 probable transmembrane helix predicted for SZO02160 by TMHMM2.0 at aa 7-26 40041001250 HMMPfam hit to PF00636, Ribonuclease III, score 1.4e-08 40041001251 1 probable transmembrane helix predicted for SZO02170 by TMHMM2.0 at aa 237-259 40041001252 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 40041001253 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032 40041001254 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 40041001255 HMMPfam hit to PF08032, RNA 2-O ribose methyltransferase, substrate binding, score 1.1e-14 40041001256 HMMPfam hit to PF00588, tRNA/rRNA methyltransferase, SpoU, score 9.1e-62 40041001257 YacP-like NYN domain; Region: NYN_YacP; cl01491 40041001258 HMMPfam hit to PF05991, Protein of unknown function DUF901, score 2.5e-83 40041001259 EDD domain protein, DegV family; Region: DegV; TIGR00762 40041001260 Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645 40041001261 HMMPfam hit to PF02645, DegV, score 1.6e-72 40041001262 Ribosomal protein L13. Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392 40041001263 23S rRNA interface [nucleotide binding]; other site 40041001264 L3 interface [polypeptide binding]; other site 40041001265 HMMPfam hit to PF00572, Ribosomal protein L13, score 2.8e-68 40041001266 PS00783 Ribosomal protein L13 signature. 40041001267 30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132 40041001268 HMMPfam hit to PF00380, Ribosomal protein S9, score 1e-58 40041001269 PS00360 Ribosomal protein S9 signature. 40041001270 genomic island 40041001271 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 40041001272 active site 40041001273 DNA binding site [nucleotide binding] 40041001274 Int/Topo IB signature motif; other site 40041001275 HMMPfam hit to PF00589, Integrase, catalytic core, phage, score 5.6e-13 40041001276 Predicted helix-turn-helix motif with score 1211.000, SD 3.31 at aa 353-374, sequence HTGATLAKKAGMSLEAISEALT 40041001277 Helix-turn-helix domain; Region: HTH_17; pfam12728 40041001278 HMMPfam hit to PF05930, Prophage CP4-57 regulatory, score 0.012 40041001279 Predicted helix-turn-helix motif with score 1420.000, SD 4.02 at aa 39-60, sequence LNKIQACQYLGISNNTLDSWIQ 40041001280 putative replication initiation protein; Region: PHA00330 40041001281 PS00133 Zinc carboxypeptidases, zinc-binding region 2 signature. 40041001282 1 probable transmembrane helix predicted for SZO02260 by TMHMM2.0 at aa 26-48 40041001283 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 40041001284 putative catalytic site [active] 40041001285 putative metal binding site [ion binding]; other site 40041001286 putative phosphate binding site [ion binding]; other site 40041001287 HMMPfam hit to PF03372, Endonuclease/exonuclease/phosphatase, score 2e-11 40041001288 PS00589 PTS HPR component serine phosphorylation site signature. 40041001290 Helix-turn-helix domain; Region: HTH_28; pfam13518 40041001291 Winged helix-turn helix; Region: HTH_29; pfam13551 40041001292 Homeodomain-like domain; Region: HTH_32; pfam13565 40041001293 Integrase core domain; Region: rve; pfam00665 40041001294 PS00017 ATP/GTP-binding site motif A (P-loop). 40041001295 HMMPfam hit to PF00665, Integrase, catalytic core, score 1.1e-18 40041001296 Ortholog of S. equi 4047 (FM204883) SEQ1966 40041001297 HMMPfam hit to PF01797, Transposase IS200-like, score 5.2e-14 40041001298 galactose mutarotase_like; Region: galactose_mutarotase_like; cd09019 40041001299 active site 40041001300 catalytic residues [active] 40041001301 HMMPfam hit to PF01263, Aldose 1-epimerase, score 1e-81 40041001302 PS00545 Aldose 1-epimerase active site. 40041001303 UDP-glucose 4-epimerase [Cell envelope biogenesis, outer membrane]; Region: GalE; COG1087 40041001304 UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247 40041001305 NAD binding site [chemical binding]; other site 40041001306 homodimer interface [polypeptide binding]; other site 40041001307 active site 40041001308 substrate binding site [chemical binding]; other site 40041001309 HMMPfam hit to PF01370, NAD-dependent epimerase/dehydratase, score 9.9e-80 40041001310 galactose-1-phosphate uridylyltransferase; Provisional; Region: PRK05270 40041001311 Galactose-1-phosphate uridyl transferase, N-terminal domain; Region: GalP_UDP_transf; pfam01087 40041001312 Galactose-1-phosphate uridyl transferase, C-terminal domain; Region: GalP_UDP_tr_C; pfam02744 40041001313 HMMPfam hit to PF02744, Galactose-1-phosphate uridyl transferase, C-terminal, score 5.6e-87 40041001314 HMMPfam hit to PF01087, Galactose-1-phosphate uridyl transferase, N-terminal, score 7.6e-89 40041001315 galactokinase; Provisional; Region: PRK05322 40041001316 Galactokinase galactose-binding signature; Region: GalKase_gal_bdg; pfam10509 40041001317 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 40041001318 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 40041001319 HMMPfam hit to PF08544, GHMP kinase, C-terminal, score 7.9e-14 40041001320 HMMPfam hit to PF00288, GHMP kinase, score 1.3e-19 40041001321 PS00012 Phosphopantetheine attachment site. 40041001322 PS00627 GHMP kinases ATP-binding domain. 40041001323 PS00106 Galactokinase signature. 40041001324 DNA-binding transcriptional repressor EbgR; Provisional; Region: PRK10339 40041001325 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 40041001326 DNA binding site [nucleotide binding] 40041001327 domain linker motif; other site 40041001328 Ligand-binding domain of DNA transcription repressor GalR which is one of two regulatory proteins involved in galactose transport and metabolism; Region: PBP1_GalR; cd01544 40041001329 putative dimerization interface [polypeptide binding]; other site 40041001330 putative ligand binding site [chemical binding]; other site 40041001331 HMMPfam hit to PF00356, Bacterial regulatory protein, LacI, score 2.4e-11 40041001332 Predicted helix-turn-helix motif with score 2116.000, SD 6.39 at aa 2-23, sequence VTLKDIAALAKVSPATVSRVLN 40041001333 PS00356 Bacterial regulatory proteins, lacI family signature. 40041001334 Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase [Lipid metabolism / General function prediction only]; Region: LCB5; COG1597 40041001335 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 40041001336 HMMPfam hit to PF00781, Diacylglycerol kinase, catalytic region, score 5.4e-36 40041001337 PS00017 ATP/GTP-binding site motif A (P-loop). 40041001338 PS00017 ATP/GTP-binding site motif A (P-loop). 40041001339 1 probable transmembrane helix predicted for SZO02400 by TMHMM2.0 at aa 487-509 40041001340 ABC-type metal ion transport system, periplasmic component/surface adhesin [Inorganic ion transport and metabolism]; Region: LraI; COG0803 40041001341 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 40041001342 intersubunit interface [polypeptide binding]; other site 40041001343 HMMPfam hit to PF01297, Periplasmic solute binding protein, score 5e-115 40041001344 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 40041001345 PS00339 Aminoacyl-transfer RNA synthetases class-II signature 2. 40041001346 streptococcal histidine triad protein; Region: strep_his_triad; TIGR01363 40041001347 Streptococcal histidine triad protein; Region: Strep_his_triad; pfam04270 40041001348 Streptococcal histidine triad protein; Region: Strep_his_triad; pfam04270 40041001349 streptococcal histidine triad protein; Region: strep_his_triad; TIGR01363 40041001350 1 probable transmembrane helix predicted for SZO02420 by TMHMM2.0 at aa 5-27 40041001351 HMMPfam hit to PF04270, Streptococcal histidine triad, score 6.1 40041001352 HMMPfam hit to PF04270, Streptococcal histidine triad, score 4.1e-35 40041001353 HMMPfam hit to PF04270, Streptococcal histidine triad, score 1.6e-10 40041001354 HMMPfam hit to PF04270, Streptococcal histidine triad, score 0.0073 40041001355 HMMPfam hit to PF04270, Streptococcal histidine triad, score 0.9 40041001356 HMMPfam hit to PF04270, Streptococcal histidine triad, score 0.035 40041001357 aspartate kinase; Reviewed; Region: PRK09034 40041001358 AAK_AKiii-YclM-BS: Amino Acid Kinase Superfamily (AAK), AKiii-YclM-BS; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the lysine plus threonine-sensitive aspartokinase isoenzyme AKIII, a monofunctional class enzyme found in...; Region: AAK_AKiii-YclM-BS; cd04245 40041001359 putative catalytic residues [active] 40041001360 putative nucleotide binding site [chemical binding]; other site 40041001361 putative aspartate binding site [chemical binding]; other site 40041001362 ACT domains located C-terminal to the catalytic domain of the lysine plus threonine-sensitive aspartokinase isoenzyme AKIII; Region: ACT_AKiii-YclM-BS_1; cd04911 40041001363 allosteric regulatory residue; other site 40041001364 ACT domains located C-terminal to the catalytic domain of the lysine plus threonine-sensitive aspartokinase isoenzyme AKIII; Region: ACT_AKiii-YclM-BS_2; cd04916 40041001365 HMMPfam hit to PF01842, Amino acid-binding ACT, score 2.2e-08 40041001366 HMMPfam hit to PF01842, Amino acid-binding ACT, score 3.8 40041001367 HMMPfam hit to PF00696, Aspartate/glutamate/uridylate kinase, score 3.4e-33 40041001368 PS00324 Aspartokinase signature. 40041001369 tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021 40041001370 Eukaryotic and bacterial pseudouridine synthases similar to E. coli TruA; Region: PseudoU_synth_EcTruA; cd02570 40041001371 dimerization interface 3.5A [polypeptide binding]; other site 40041001372 active site 40041001373 HMMPfam hit to PF01416, tRNA pseudouridine synthase, score 4.4e-39 40041001374 HMMPfam hit to PF01416, tRNA pseudouridine synthase, score 3.9e-32 40041001375 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 40041001376 dimer interface [polypeptide binding]; other site 40041001377 substrate binding site [chemical binding]; other site 40041001378 ATP binding site [chemical binding]; other site 40041001379 HMMPfam hit to PF08543, Phosphomethylpyrimidine kinase type-1, score 2.8e-65 40041001380 ECF-type riboflavin transporter, S component; Region: ECF-ribofla_trS; pfam07155 40041001381 4 probable transmembrane helices predicted for SZO02470 by TMHMM2.0 at aa 7-26, 53-75, 95-117 and 122-144 40041001382 hypothetical protein; Provisional; Region: PRK13690 40041001383 HMMPfam hit to PF04260, Conserved hypothetical protein CHP01440, score 2.2e-115 40041001384 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 40041001385 Mechanosensitive ion channel; Region: MS_channel; pfam00924 40041001386 HMMPfam hit to PF00924, MscS Mechanosensitive ion channel, score 2.5e-52 40041001387 3 probable transmembrane helices predicted for SZO02490 by TMHMM2.0 at aa 15-37, 73-95 and 105-127 40041001388 Alpha amylase catalytic domain found in bacterial Alpha-amylases (also called 1,4-alpha-D-glucan-4-glucanohydrolase); Region: AmyAc_bac1_AmyA; cd11315 40041001389 Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366 40041001390 active site 40041001391 Ca binding site [ion binding]; other site 40041001392 catalytic site [active] 40041001393 HMMPfam hit to PF00128, Glycosyl hydrolase, family 13, catalytic region, score 1.1e-53 40041001394 trigger factor; Provisional; Region: tig; PRK01490 40041001395 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 40041001396 Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698 40041001397 HMMPfam hit to PF05697, Bacterial trigger factor, N-terminal, score 2.9e-60 40041001398 HMMPfam hit to PF00254, Peptidyl-prolyl cis-trans isomerase, FKBP-type, score 1.3e-28 40041001399 HMMPfam hit to PF05698, Bacterial trigger factor, C-terminal, score 1.1e-67 40041001400 Predicted helix-turn-helix motif with score 987.000, SD 2.55 at aa 382-403, sequence KEINDLAAEYSMPVEQVRSLLS 40041001401 DNA-directed RNA polymerase delta subunit; Region: RNA_pol_delta; pfam05066 40041001402 HMMPfam hit to PF05066, DNA-directed RNA polymerase delta subunit, score 2.3e-98 40041001403 CTP synthetase; Validated; Region: pyrG; PRK05380 40041001404 CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113 40041001405 Catalytic site [active] 40041001406 active site 40041001407 UTP binding site [chemical binding]; other site 40041001408 Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746 40041001409 active site 40041001410 putative oxyanion hole; other site 40041001411 catalytic triad [active] 40041001412 HMMPfam hit to PF06418, CTP synthase, score 2.9e-216 40041001413 HMMPfam hit to PF00117, Glutamine amidotransferase class-I, score 5.5e-70 40041001414 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 40041001415 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 40041001416 1 probable transmembrane helix predicted for SZO02540 by TMHMM2.0 at aa 9-31 40041001417 fructose-bisphosphate aldolase; Provisional; Region: PRK09197 40041001418 Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947 40041001419 intersubunit interface [polypeptide binding]; other site 40041001420 active site 40041001421 zinc binding site [ion binding]; other site 40041001422 Na+ binding site [ion binding]; other site 40041001423 HMMPfam hit to PF01116, Ketose-bisphosphate aldolase, class-II, score 1.3e-112 40041001424 PS00602 Fructose-bisphosphate aldolase class-II signature 1. 40041001425 PS00806 Fructose-bisphosphate aldolase class-II signature 2. 40041001426 Ortholog of S. equi 4047 (FM204883) SEQ1942 40041001427 1 probable transmembrane helix predicted for SZO02570 by TMHMM2.0 at aa 12-34 40041001428 Helix-turn-helix domain; Region: HTH_28; pfam13518 40041001429 Winged helix-turn helix; Region: HTH_29; pfam13551 40041001430 Homeodomain-like domain; Region: HTH_32; pfam13565 40041001431 Integrase core domain; Region: rve; pfam00665 40041001432 HMMPfam hit to PF00665, Integrase, catalytic core, score 3.4e-18 40041001433 PS00017 ATP/GTP-binding site motif A (P-loop). 40041001434 50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359 40041001435 HMMPfam hit to PF00830, Ribosomal protein L28, score 3.2e-24 40041001436 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1302 40041001437 HMMPfam hit to PF03780, Protein of unknown function DUF322, score 1.9e-53 40041001438 DAK2 domain fusion protein YloV; Region: YloV; TIGR03599 40041001439 DAK2 domain; Region: Dak2; pfam02734 40041001440 HMMPfam hit to PF02734, Dak phosphatase, score 1.1e-75 40041001441 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 40041001442 A subgroup of the band 7 domain of flotillin (reggie) like proteins. This subgroup contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin. Many of these band 7 domain-containing proteins are lipid raft-associated. Individual...; Region: Band_7_4; cd03407 40041001443 1 probable transmembrane helix predicted for SZO02620 by TMHMM2.0 at aa 4-26 40041001444 HMMPfam hit to PF01145, Band 7 protein, score 4.4e-41 40041001445 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 40041001446 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 40041001447 Walker A/P-loop; other site 40041001448 ATP binding site [chemical binding]; other site 40041001449 Q-loop/lid; other site 40041001450 ABC transporter signature motif; other site 40041001451 Walker B; other site 40041001452 D-loop; other site 40041001453 H-loop/switch region; other site 40041001454 HMMPfam hit to PF00005, ABC transporter related, score 7.9e-62 40041001455 PS00211 ABC transporters family signature. 40041001456 PS00017 ATP/GTP-binding site motif A (P-loop). 40041001457 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 40041001458 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 40041001459 substrate binding pocket [chemical binding]; other site 40041001460 membrane-bound complex binding site; other site 40041001461 hinge residues; other site 40041001462 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 40041001463 dimer interface [polypeptide binding]; other site 40041001464 conserved gate region; other site 40041001465 putative PBP binding loops; other site 40041001466 ABC-ATPase subunit interface; other site 40041001467 HMMPfam hit to PF00528, Binding-protein-dependent transport systems inner membrane component, score 1.2e-23 40041001468 4 probable transmembrane helices predicted for SZO02650 by TMHMM2.0 at aa 5-24, 298-320, 360-382 and 473-495 40041001469 PS00402 Binding-protein-dependent transport systems inner membrane comp. sign. 40041001470 HMMPfam hit to PF00497, Bacterial extracellular solute-binding protein, family 3, score 2e-34 40041001471 undecaprenyl pyrophosphate phosphatase; Reviewed; Region: PRK00281 40041001472 8 probable transmembrane helices predicted for SZO02660 by TMHMM2.0 at aa 2-24, 44-66, 87-105, 115-133, 154-176, 186-208, 221-243 and 258-275 40041001473 HMMPfam hit to PF02673, Bacitracin resistance protein BacA, score 1.6e-118 40041001474 adaptor protein; Provisional; Region: PRK02315 40041001475 HMMPfam hit to PF05389, Negative regulator of genetic competence, score 9.1e-114 40041001476 Predicted helix-turn-helix motif with score 1036.000, SD 2.72 at aa 84-105, sequence LNFEDLADLGDISQMTPEDFFR 40041001477 UDP-N-acetylmuramyl pentapeptide phosphotransferase/UDP-N- acetylglucosamine-1-phosphate transferase [Cell envelope biogenesis, outer membrane]; Region: Rfe; COG0472 40041001478 This subfamily contains Escherichia coli WecA, Bacillus subtilis TagO and related proteins. WecA is an UDP-N-acetylglucosamine (GlcNAc):undecaprenyl-phosphate (Und-P) GlcNAc-1-phosphate transferase that catalyzes the formation of a phosphodiester bond...; Region: GT_WecA_like; cd06853 40041001479 Mg++ binding site [ion binding]; other site 40041001480 putative catalytic motif [active] 40041001481 substrate binding site [chemical binding]; other site 40041001482 11 probable transmembrane helices predicted for SZO02680 by TMHMM2.0 at aa 10-31, 52-71, 81-103, 110-129, 144-163, 175-197, 201-218, 225-244, 254-276, 306-328 and 333-355 40041001483 HMMPfam hit to PF00953, Glycosyl transferase, family 4, score 8e-41 40041001484 Cysteine desulfurase activator ATPase [Posttranslational modification, protein turnover, chaperones]; Region: sufC; COG0396 40041001485 ABC-type transport system involved in Fe-S cluster assembly, ATPase component; Region: ABC_FeS_Assembly; cd03217 40041001486 Walker A/P-loop; other site 40041001487 ATP binding site [chemical binding]; other site 40041001488 Q-loop/lid; other site 40041001489 ABC transporter signature motif; other site 40041001490 Walker B; other site 40041001491 D-loop; other site 40041001492 H-loop/switch region; other site 40041001493 HMMPfam hit to PF00005, ABC transporter related, score 5.3e-31 40041001494 PS00017 ATP/GTP-binding site motif A (P-loop). 40041001495 PS00211 ABC transporters family signature. 40041001496 Cysteine desulfurase activator SufB [Posttranslational modification, protein turnover, chaperones]; Region: SufB; COG0719 40041001497 FeS assembly protein SufD; Region: sufD; TIGR01981 40041001498 HMMPfam hit to PF01458, SUF system FeS cluster assembly, SufBD, score 1.9e-50 40041001499 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 40041001500 Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453 40041001501 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 40041001502 catalytic residue [active] 40041001503 HMMPfam hit to PF00266, Aminotransferase, class V, score 1.9e-213 40041001504 PS00595 Aminotransferases class-V pyridoxal-phosphate attachment site. 40041001505 NifU homolog involved in Fe-S cluster formation [Energy production and conversion]; Region: IscU; COG0822 40041001506 Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664 40041001507 trimerization site [polypeptide binding]; other site 40041001508 active site 40041001509 HMMPfam hit to PF01592, NIF system FeS cluster assembly, NifU, N-terminal, score 3.5e-28 40041001510 cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814; cl03223 40041001511 FeS assembly protein SufB; Region: sufB; TIGR01980 40041001512 HMMPfam hit to PF01458, SUF system FeS cluster assembly, SufBD, score 8.2e-116 40041001513 D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768 40041001514 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 40041001515 2 probable transmembrane helices predicted for SZO02740 by TMHMM2.0 at aa 5-23 and 368-390 40041001516 HMMPfam hit to PF00768, Peptidase S11, D-alanyl-D-alanine carboxypeptidase A, score 5.3e-33 40041001517 D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: DacC; COG1686 40041001518 Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; smart00936 40041001519 HMMPfam hit to PF00768, Peptidase S11, D-alanyl-D-alanine carboxypeptidase A, score 9.3e-93 40041001520 D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: DacC; COG1686 40041001521 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 40041001522 Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; smart00936 40041001523 HMMPfam hit to PF07943, Peptidase S11, D-Ala-D-Ala carboxypeptidase A, C-terminal, score 2.4e-09 40041001524 HMMPfam hit to PF00768, Peptidase S11, D-alanyl-D-alanine carboxypeptidase A, score 7.4e-107 40041001525 PS00307 Legume lectins beta-chain signature. 40041001526 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 40041001527 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 40041001528 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 40041001529 peptide binding site [polypeptide binding]; other site 40041001530 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 40041001531 HMMPfam hit to PF00496, Bacterial extracellular solute-binding protein, family 5, score 3.5e-47 40041001532 PS01040 Bacterial extracellular solute-binding proteins, family 5 signature. 40041001533 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 40041001534 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 40041001535 dimer interface [polypeptide binding]; other site 40041001536 conserved gate region; other site 40041001537 putative PBP binding loops; other site 40041001538 ABC-ATPase subunit interface; other site 40041001539 6 probable transmembrane helices predicted for SZO02780 by TMHMM2.0 at aa 9-31, 287-309, 321-343, 358-380, 419-441 and 461-483 40041001540 HMMPfam hit to PF00528, Binding-protein-dependent transport systems inner membrane component, score 6.6e-52 40041001541 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 40041001542 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 40041001543 dimer interface [polypeptide binding]; other site 40041001544 conserved gate region; other site 40041001545 putative PBP binding loops; other site 40041001546 ABC-ATPase subunit interface; other site 40041001547 6 probable transmembrane helices predicted for SZO02790 by TMHMM2.0 at aa 42-64, 110-132, 145-167, 171-193, 214-236 and 274-296 40041001548 HMMPfam hit to PF00528, Binding-protein-dependent transport systems inner membrane component, score 5.7e-37 40041001549 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 40041001550 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 40041001551 Walker A/P-loop; other site 40041001552 ATP binding site [chemical binding]; other site 40041001553 Q-loop/lid; other site 40041001554 ABC transporter signature motif; other site 40041001555 Walker B; other site 40041001556 D-loop; other site 40041001557 H-loop/switch region; other site 40041001558 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 40041001559 HMMPfam hit to PF00005, ABC transporter related, score 2.1e-70 40041001560 PS00017 ATP/GTP-binding site motif A (P-loop). 40041001561 PS00211 ABC transporters family signature. 40041001562 HMMPfam hit to PF08352, Oligopeptide/dipeptide ABC transporter, C-terminal, score 3.8e-23 40041001563 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 40041001564 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 40041001565 Walker A/P-loop; other site 40041001566 ATP binding site [chemical binding]; other site 40041001567 Q-loop/lid; other site 40041001568 ABC transporter signature motif; other site 40041001569 Walker B; other site 40041001570 D-loop; other site 40041001571 H-loop/switch region; other site 40041001572 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 40041001573 HMMPfam hit to PF00005, ABC transporter related, score 1.9e-52 40041001574 PS00017 ATP/GTP-binding site motif A (P-loop). 40041001575 PS00211 ABC transporters family signature. 40041001576 HMMPfam hit to PF08352, Oligopeptide/dipeptide ABC transporter, C-terminal, score 1.6e-07 40041001577 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 40041001578 Helix-turn-helix domain; Region: HTH_38; pfam13936 40041001579 Integrase core domain; Region: rve; pfam00665 40041001580 HMMPfam hit to PF00665, Integrase, catalytic core, score 7.6e-11 40041001581 Predicted helix-turn-helix motif with score 1377.000, SD 3.88 at aa 22-43, sequence KPFSAIAAKLGKDPSTISKEVR 40041001582 Predicted hydrolase of the HAD superfamily [General function prediction only]; Region: COG2179 40041001583 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 40041001584 active site 40041001585 motif I; other site 40041001586 motif II; other site 40041001587 PS00678 Trp-Asp (WD) repeats signature. 40041001588 HMMPfam hit to PF00702, Haloacid dehalogenase-like hydrolase, score 1.8e-09 40041001589 GTPase YqeH; Provisional; Region: PRK13796 40041001590 Circularly permuted YqeH GTPase; Region: YqeH; cd01855 40041001591 GTP/Mg2+ binding site [chemical binding]; other site 40041001592 G4 box; other site 40041001593 G5 box; other site 40041001594 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 40041001595 G1 box; other site 40041001596 G1 box; other site 40041001597 GTP/Mg2+ binding site [chemical binding]; other site 40041001598 G2 box; other site 40041001599 Switch I region; other site 40041001600 G2 box; other site 40041001601 Switch I region; other site 40041001602 G3 box; other site 40041001603 G3 box; other site 40041001604 Switch II region; other site 40041001605 Switch II region; other site 40041001606 G4 box; other site 40041001607 HMMPfam hit to PF01926, GTP-binding protein, HSR1-related, score 8.6e-11 40041001608 PS00017 ATP/GTP-binding site motif A (P-loop). 40041001609 Predicted RNA-binding protein containing KH domain, possibly ribosomal protein [Translation, ribosomal structure and biogenesis]; Region: COG1534 40041001610 HMMPfam hit to PF01985, CRS1/YhbY, score 4.6e-34 40041001611 nicotinic acid mononucleotide adenylyltransferase; Provisional; Region: nadD; PRK00071 40041001612 Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165 40041001613 active site 40041001614 (T/H)XGH motif; other site 40041001615 HMMPfam hit to PF01467, Cytidylyltransferase, score 4e-61 40041001616 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 40041001617 Zn2+ binding site [ion binding]; other site 40041001618 Mg2+ binding site [ion binding]; other site 40041001619 HMMPfam hit to PF01966, Metal-dependent phosphohydrolase, HD region, subdomain, score 9e-11 40041001620 Uncharacterized homolog of plant Iojap protein [Function unknown]; Region: COG0799 40041001621 HMMPfam hit to PF02410, Iojap-related protein, score 3.5e-44 40041001622 SAM-dependent methyltransferases [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: SmtA; COG0500 40041001623 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 40041001624 S-adenosylmethionine binding site [chemical binding]; other site 40041001625 HMMPfam hit to PF08241, Methyltransferase type 11, score 4.1e-23 40041001626 hypothetical protein; Provisional; Region: PRK13670 40041001627 HIGH Nucleotidyl Transferase; Region: HIGH_NTase1; cl17673 40041001628 HMMPfam hit to PF05636, Protein of unknown function DUF795, score 4.1e-177 40041001629 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 40041001630 Helix-Turn-Helix DNA binding domain of the transcription regulators TipAL, Mta, and SkgA; Region: HTH_TipAL-Mta; cd01106 40041001631 DNA binding residues [nucleotide binding] 40041001632 dimer interface [polypeptide binding]; other site 40041001633 TipAS antibiotic-recognition domain; Region: TipAS; pfam07739 40041001634 Predicted helix-turn-helix motif with score 1160.000, SD 3.14 at aa 2-23, sequence KTVKDVSQLTGLSVRTLHYYDE 40041001635 HMMPfam hit to PF00376, Bacterial regulatory protein, MerR, score 1.1e-13 40041001636 HMMPfam hit to PF07739, TipAS antibiotic-recognition, score 8.9e-34 40041001637 hypothetical protein; Provisional; Region: PRK12378 40041001638 HMMPfam hit to PF01709, Protein of unknown function DUF28, score 4.3e-125 40041001639 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 40041001640 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 40041001641 substrate binding pocket [chemical binding]; other site 40041001642 membrane-bound complex binding site; other site 40041001643 hinge residues; other site 40041001644 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 40041001645 HMMPfam hit to PF00497, Bacterial extracellular solute-binding protein, family 3, score 8.3e-76 40041001646 ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464 40041001647 NLPA lipoprotein; Region: Lipoprotein_9; pfam03180 40041001648 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 40041001649 HMMPfam hit to PF03180, NLPA lipoprotein, score 1.4e-112 40041001650 hypothetical protein; Provisional; Region: PRK06446 40041001651 Uncharacterized M20 Dipeptidases; Region: M20_dipept_like_4; cd05681 40041001652 metal binding site [ion binding]; metal-binding site 40041001653 dimer interface [polypeptide binding]; other site 40041001654 HMMPfam hit to PF01546, Peptidase M20, score 8.6e-27 40041001655 HMMPfam hit to PF07687, Peptidase M20, dimerisation, score 2.3e-13 40041001656 ABC-type metal ion transport system, ATPase component [Inorganic ion transport and metabolism]; Region: AbcC; COG1135 40041001657 ATP-binding cassette domain of methionine transporter; Region: ABC_MetN_methionine_transporter; cd03258 40041001658 Walker A/P-loop; other site 40041001659 ATP binding site [chemical binding]; other site 40041001660 Q-loop/lid; other site 40041001661 ABC transporter signature motif; other site 40041001662 Walker B; other site 40041001663 D-loop; other site 40041001664 H-loop/switch region; other site 40041001665 NIL domain; Region: NIL; pfam09383 40041001666 HMMPfam hit to PF00005, ABC transporter related, score 1.4e-67 40041001667 PS00017 ATP/GTP-binding site motif A (P-loop). 40041001668 PS00211 ABC transporters family signature. 40041001669 ABC-type metal ion transport system, permease component [Inorganic ion transport and metabolism]; Region: AbcD; COG2011 40041001670 HMMPfam hit to PF00528, Binding-protein-dependent transport systems inner membrane component, score 6.1e-13 40041001671 4 probable transmembrane helices predicted for SZO02980 by TMHMM2.0 at aa 32-54, 75-97, 166-188 and 201-220 40041001672 Branched-chain amino acid transport protein; Region: Branch_AA_trans; pfam05525 40041001673 HMMPfam hit to PF05525, Branched-chain amino acid transport system II carrier protein, score 3.9e-209 40041001674 12 probable transmembrane helices predicted for SZO02990 by TMHMM2.0 at aa 7-29, 39-61, 78-97, 117-136, 148-170, 192-214, 234-256, 296-318, 331-353, 357-376, 385-407 and 427-449 40041001675 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 40041001676 serine/threonine transporter SstT; Provisional; Region: PRK13628 40041001677 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 40041001678 HMMPfam hit to PF00375, Sodium:dicarboxylate symporter, score 7.9e-113 40041001679 9 probable transmembrane helices predicted for SZO03000 by TMHMM2.0 at aa 17-39, 43-65, 78-100, 136-158, 178-200, 210-232, 287-309, 324-346 and 353-375 40041001680 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 40041001681 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 40041001682 TrkA-N domain; Region: TrkA_N; pfam02254 40041001683 HMMPfam hit to PF02254, TrkA-N, score 1e-37 40041001684 Trk-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: TrkG; COG0168 40041001685 potassium uptake protein, TrkH family; Region: 2a38; TIGR00933 40041001686 HMMPfam hit to PF02386, Cation transporter, score 1.4e-61 40041001687 9 probable transmembrane helices predicted for SZO03020 by TMHMM2.0 at aa 15-37, 49-67, 77-99, 128-150, 160-182, 195-217, 242-261, 365-384 and 419-441 40041001688 Predicted S-adenosylmethionine-dependent methyltransferase involved in bacterial cell division [Cell envelope biogenesis, outer membrane]; Region: GidB; COG0357 40041001689 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 40041001690 S-adenosylmethionine binding site [chemical binding]; other site 40041001691 HMMPfam hit to PF02527, Glucose inhibited division protein, score 7.4e-58 40041001692 Uncharacterized conserved protein [Function unknown]; Region: LemA; COG1704 40041001693 HMMPfam hit to PF04011, LemA, score 6.6e-108 40041001694 1 probable transmembrane helix predicted for SZO03040 by TMHMM2.0 at aa 4-26 40041001695 heat shock protein HtpX; Provisional; Region: PRK04897 40041001696 4 probable transmembrane helices predicted for SZO03050 by TMHMM2.0 at aa 13-35, 45-67, 157-179 and 194-216 40041001697 HMMPfam hit to PF01435, Peptidase M48, Ste24p, score 9.5e-25 40041001698 Uncharacterized ACR, COG1399; Region: DUF177; cl00616 40041001699 HMMPfam hit to PF02620, Protein of unknown function DUF177, score 4.7e-44 40041001700 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 40041001701 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 40041001702 active site 40041001703 phosphorylation site [posttranslational modification] 40041001704 intermolecular recognition site; other site 40041001705 dimerization interface [polypeptide binding]; other site 40041001706 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 40041001707 DNA binding site [nucleotide binding] 40041001708 HMMPfam hit to PF00072, Response regulator receiver, score 8.5e-43 40041001709 PS00217 Sugar transport proteins signature 2. 40041001710 HMMPfam hit to PF00486, Transcriptional regulatory protein, C-terminal, score 1.6e-19 40041001711 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 40041001712 HAMP domain; Region: HAMP; pfam00672 40041001713 dimerization interface [polypeptide binding]; other site 40041001714 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 40041001715 dimer interface [polypeptide binding]; other site 40041001716 phosphorylation site [posttranslational modification] 40041001717 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 40041001718 ATP binding site [chemical binding]; other site 40041001719 Mg2+ binding site [ion binding]; other site 40041001720 G-X-G motif; other site 40041001721 2 probable transmembrane helices predicted for SZO03080 by TMHMM2.0 at aa 20-42 and 187-209 40041001722 HMMPfam hit to PF00672, Histidine kinase, HAMP region, score 9.5e-11 40041001723 HMMPfam hit to PF00512, Histidine kinase A, N-terminal, score 8e-17 40041001724 HMMPfam hit to PF02518, ATP-binding region, ATPase-like, score 2.1e-31 40041001725 transcriptional regulator NrdR; Validated; Region: nrdR; PRK00464 40041001726 ATP cone domain; Region: ATP-cone; pfam03477 40041001727 PS00190 Cytochrome c family heme-binding site signature. 40041001728 HMMPfam hit to PF03477, ATP-cone, score 2.2e-33 40041001729 Replication initiation/membrane attachment protein [DNA replication, recombination, and repair]; Region: DnaB; COG3611 40041001730 HMMPfam hit to PF07261, Replication initiation and membrane attachment, score 1.3e-06 40041001731 Predicted helix-turn-helix motif with score 979.000, SD 2.52 at aa 359-380, sequence TSQEEQAKLEQFKQAALKRLEN 40041001732 primosomal protein DnaI; Reviewed; Region: PRK08939 40041001733 Primosomal protein DnaI N-terminus; Region: DnaI_N; pfam07319 40041001734 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 40041001735 Walker A motif; other site 40041001736 ATP binding site [chemical binding]; other site 40041001737 Walker B motif; other site 40041001738 HMMPfam hit to PF07319, Primosomal DnaI, N-terminal, score 2.3e-45 40041001739 PS00017 ATP/GTP-binding site motif A (P-loop). 40041001740 GTP-binding protein Der; Reviewed; Region: PRK00093 40041001741 EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894 40041001742 G1 box; other site 40041001743 GTP/Mg2+ binding site [chemical binding]; other site 40041001744 Switch I region; other site 40041001745 G2 box; other site 40041001746 Switch II region; other site 40041001747 G3 box; other site 40041001748 G4 box; other site 40041001749 G5 box; other site 40041001750 EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895 40041001751 G1 box; other site 40041001752 GTP/Mg2+ binding site [chemical binding]; other site 40041001753 Switch I region; other site 40041001754 G2 box; other site 40041001755 G3 box; other site 40041001756 Switch II region; other site 40041001757 G4 box; other site 40041001758 G5 box; other site 40041001759 HMMPfam hit to PF01926, GTP-binding protein, HSR1-related, score 6.5e-46 40041001760 PS00017 ATP/GTP-binding site motif A (P-loop). 40041001761 HMMPfam hit to PF01926, GTP-binding protein, HSR1-related, score 3.7e-41 40041001762 PS00017 ATP/GTP-binding site motif A (P-loop). 40041001763 SWIM zinc finger; Region: SWIM; pfam04434 40041001764 Bacterial SNF2 helicase associated; Region: SNF2_assoc; pfam08455 40041001765 SNF2 family N-terminal domain; Region: SNF2_N; pfam00176 40041001766 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 40041001767 ATP binding site [chemical binding]; other site 40041001768 putative Mg++ binding site [ion binding]; other site 40041001769 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 40041001770 nucleotide binding region [chemical binding]; other site 40041001771 ATP-binding site [chemical binding]; other site 40041001772 HMMPfam hit to PF04434, Zinc finger, SWIM-type, score 4.6e-07 40041001773 HMMPfam hit to PF08455, Helicase, SWF/SNF/SWI type, bacterial, score 1.8e-128 40041001774 HMMPfam hit to PF00176, SNF2-related, score 1.9e-59 40041001775 HMMPfam hit to PF00271, DNA/RNA helicase, C-terminal, score 5.1e-27 40041001776 UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421 40041001777 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 40041001778 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 40041001779 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 40041001780 HMMPfam hit to PF01225, Mur ligase, N-terminal, score 4.6e-37 40041001781 HMMPfam hit to PF08245, Mur ligase, central, score 2.1e-26 40041001782 HMMPfam hit to PF02875, Mur ligase, C-terminal, score 1.2e-18 40041001783 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 40041001784 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 40041001785 Coenzyme A binding pocket [chemical binding]; other site 40041001786 HMMPfam hit to PF00583, GCN5-related N-acetyltransferase, score 2e-10 40041001787 Aminodeoxychorismate lyase [Coenzyme transport and metabolism]; Region: COG1559 40041001788 proteins similar to Escherichia coli yceG; Region: yceG_like; cd08010 40041001789 dimerization interface [polypeptide binding]; other site 40041001790 1 probable transmembrane helix predicted for SZO03170 by TMHMM2.0 at aa 155-177 40041001791 HMMPfam hit to PF02618, Aminodeoxychorismate lyase, score 2.1e-137 40041001792 PS00017 ATP/GTP-binding site motif A (P-loop). 40041001793 transcription elongation factor GreA; Reviewed; Region: greA; PRK00226 40041001794 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 40041001795 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 40041001796 HMMPfam hit to PF03449, Transcription elongation factor, GreA/GreB region, prokaryotic, score 3e-24 40041001797 HMMPfam hit to PF01272, Transcription elongation factor, GreA/GreB region, prokaryotic, score 2.2e-16 40041001798 PS00830 Prokaryotic transcription elongation factors signature 2. 40041001799 OxaA-like protein precursor; Provisional; Region: PRK02463 40041001800 membrane protein insertase, YidC/Oxa1 family, C-terminal domain; Region: yidC_oxa1_cterm; TIGR03592 40041001801 HMMPfam hit to PF02096, 60 kDa inner membrane insertion protein, score 1.1e-36 40041001802 5 probable transmembrane helices predicted for SZO03190 by TMHMM2.0 at aa 7-26, 58-80, 135-157, 177-199 and 220-242 40041001803 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 40041001804 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 40041001805 acylphosphatase; Provisional; Region: PRK14434 40041001806 HMMPfam hit to PF00708, Acylphosphatase, score 2.9e-07 40041001807 PS00150 Acylphosphatase signature 1. 40041001808 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 40041001809 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; smart00967 40041001810 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 40041001811 HMMPfam hit to PF08032, RNA 2-O ribose methyltransferase, substrate binding, score 1.9e-15 40041001812 HMMPfam hit to PF00588, tRNA/rRNA methyltransferase, SpoU, score 2.7e-51 40041001813 Predicted HD superfamily hydrolase [General function prediction only]; Region: COG1418 40041001814 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl17215 40041001815 Zn2+ binding site [ion binding]; other site 40041001816 Mg2+ binding site [ion binding]; other site 40041001817 HMMPfam hit to PF01966, Metal-dependent phosphohydrolase, HD region, subdomain, score 7.7e-05 40041001818 Integral membrane protein, interacts with FtsH [General function prediction only]; Region: COG0670 40041001819 Bacterial BAX inhibitor (BI)-1/YccA-like proteins; Region: BI-1-like_bacterial; cd10432 40041001820 HMMPfam hit to PF01027, Protein of unknown function UPF0005, score 8.5e-21 40041001821 7 probable transmembrane helices predicted for SZO03230 by TMHMM2.0 at aa 21-43, 58-76, 83-105, 110-129, 142-159, 163-182 and 202-224 40041001822 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3763 40041001823 1 probable transmembrane helix predicted for SZO03240 by TMHMM2.0 at aa 4-26 40041001824 HMMPfam hit to PF03672, Protein of unknown function UPF0154, score 5.1e-19 40041001825 glutamate racemase; Provisional; Region: PRK00865 40041001826 HMMPfam hit to PF01177, Asp/Glu/hydantoin racemase, score 1.6e-100 40041001827 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 40041001828 PS00924 Aspartate and glutamate racemases signature 2. 40041001829 putative deoxyribonucleotide triphosphate pyrophosphatase/unknown domain fusion protein; Reviewed; Region: PRK02491 40041001830 NTPase/HAM1. This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515 40041001831 active site 40041001832 dimerization interface [polypeptide binding]; other site 40041001833 HMMPfam hit to PF01725, Ham1-like protein, score 2e-66 40041001834 PS00017 ATP/GTP-binding site motif A (P-loop). 40041001835 Escherichia coli YfcE and related proteins, metallophosphatase domain; Region: MPP_YfcE; cd00841 40041001836 active site 40041001837 metal binding site [ion binding]; metal-binding site 40041001838 homotetramer interface [polypeptide binding]; other site 40041001839 HMMPfam hit to PF00149, Metallophosphoesterase, score 0.00093 40041001840 PS00017 ATP/GTP-binding site motif A (P-loop). 40041001841 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_30; cd04643 40041001842 FOG: CBS domain [General function prediction only]; Region: COG0517 40041001843 HMMPfam hit to PF00571, Cystathionine beta-synthase, core, score 2.4e-21 40041001844 site-specific tyrosine recombinase XerD-like protein; Reviewed; Region: xerD; PRK02436 40041001845 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 40041001846 DNA binding site [nucleotide binding] 40041001847 active site 40041001848 Int/Topo IB signature motif; other site 40041001849 catalytic residues [active] 40041001850 HMMPfam hit to PF00589, Integrase, catalytic core, phage, score 0.037 40041001851 segregation and condensation protein A; Reviewed; Region: scpA; PRK00104 40041001852 HMMPfam hit to PF02616, Prokaryotic chromosome segregation and condensation protein ScpA, score 2.7e-24 40041001853 segregation and condensation protein B; Reviewed; Region: scpB; PRK00135 40041001854 HMMPfam hit to PF04079, Prokaryotic chromosome segregation and condensation protein ScpB, score 1.3e-74 40041001855 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 40041001856 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 40041001857 RNA binding surface [nucleotide binding]; other site 40041001858 Pseudouridine synthases, RsuA subfamily; Region: PseudoU_synth_RsuA_like; cd02870 40041001859 active site 40041001860 HMMPfam hit to PF01479, RNA-binding S4, score 2.8e-15 40041001861 HMMPfam hit to PF00849, Pseudouridine synthase, score 1.1e-23 40041001862 PS01149 Rsu family of pseudouridine synthase signature. 40041001863 hypothetical protein; Validated; Region: PRK00041 40041001864 HMMPfam hit to PF01809, Protein of unknown function DUF37, score 9.4e-35 40041001865 Predicted rRNA methylase (SpoU class) [Translation, ribosomal structure and biogenesis]; Region: CspR; COG0219 40041001866 HMMPfam hit to PF00588, tRNA/rRNA methyltransferase, SpoU, score 2.6e-42 40041001867 1 probable transmembrane helix predicted for SZO03350 by TMHMM2.0 at aa 7-26 40041001868 1 probable transmembrane helix predicted for SZO03360 by TMHMM2.0 at aa 10-27 40041001869 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 40041001870 1 probable transmembrane helix predicted for SZO03370 by TMHMM2.0 at aa 7-29 40041001871 1 probable transmembrane helix predicted for SZO03380 by TMHMM2.0 at aa 7-29 40041001872 Lipase. Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is "interfacial activation", the process of...; Region: Lipase; cl14883 40041001873 nucleophilic elbow; other site 40041001874 catalytic triad; other site 40041001875 PS00120 Lipases, serine active site. 40041001876 Predicted membrane protein [Function unknown]; Region: COG3601 40041001877 Protein of unknown function (DUF3816); Region: DUF3816; pfam12822 40041001878 5 probable transmembrane helices predicted for SZO03420 by TMHMM2.0 at aa 15-37, 44-66, 86-105, 117-139 and 159-181 40041001879 PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392 40041001880 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 40041001881 active site 40041001882 6 probable transmembrane helices predicted for SZO03430 by TMHMM2.0 at aa 7-29, 58-80, 87-109, 124-146, 153-175 and 185-202 40041001883 HMMPfam hit to PF01569, Phosphatidic acid phosphatase type 2-like, score 1.4e-32 40041001884 Predicted Fe-S oxidoreductase [General function prediction only]; Region: COG1242 40041001885 HMMPfam hit to PF04055, Radical SAM, score 5.5e-11 40041001886 Phosphotransferase enzyme family; Region: APH; pfam01636 40041001887 Aminoglycoside 3'-phosphotransferase (APH). The APH subfamily is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs), RIO kinases, actin-fragmin...; Region: APH; cd05150 40041001888 active site 40041001889 ATP binding site [chemical binding]; other site 40041001890 antibiotic binding site [chemical binding]; other site 40041001891 HMMPfam hit to PF01636, Aminoglycoside phosphotransferase, score 5.4e-18 40041001892 PS00109 Tyrosine protein kinases specific active-site signature. 40041001893 Putative rRNA methylase; Region: rRNA_methylase; pfam06962 40041001894 HMMPfam hit to PF06962, rRNA methylase, score 3.7e-83 40041001895 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 40041001896 Domain of unknown function DUF21; Region: DUF21; pfam01595 40041001897 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 40041001898 Transporter associated domain; Region: CorC_HlyC; smart01091 40041001899 4 probable transmembrane helices predicted for SZO03470 by TMHMM2.0 at aa 10-29, 71-93, 103-125 and 137-159 40041001900 HMMPfam hit to PF01595, Protein of unknown function DUF21, score 2.5e-73 40041001901 HMMPfam hit to PF00571, Cystathionine beta-synthase, core, score 4.1e-24 40041001902 HMMPfam hit to PF03471, Transporter-associated region, score 3.1e-23 40041001903 pyruvate formate-lyase 1-activating enzyme; Region: PFLA; TIGR02493 40041001904 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 40041001905 FeS/SAM binding site; other site 40041001906 PS01087 Radical activating enzymes signature. 40041001907 HMMPfam hit to PF04055, Radical SAM, score 2.2e-29 40041001908 PS00190 Cytochrome c family heme-binding site signature. 40041001909 putative manganese-dependent inorganic pyrophosphatase; Provisional; Region: PRK05427 40041001910 DHH family; Region: DHH; pfam01368 40041001911 DHHA2 domain; Region: DHHA2; pfam02833 40041001912 HMMPfam hit to PF01368, Phosphoesterase, RecJ-like, score 7.1e-20 40041001913 HMMPfam hit to PF02833, DHHA2, score 5.8e-53 40041001914 Domain of unknown function (DUF1803); Region: DUF1803; pfam08820 40041001915 Domain of unknown function (DUF1803); Region: DUF1803; pfam08820 40041001916 HMMPfam hit to PF08820, Protein of unknown function DUF1803, score 9.1e-38 40041001917 HMMPfam hit to PF08820, Protein of unknown function DUF1803, score 5.4e-38 40041001918 ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779 40041001919 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 40041001920 ABC-ATPase subunit interface; other site 40041001921 dimer interface [polypeptide binding]; other site 40041001922 putative PBP binding regions; other site 40041001923 HMMPfam hit to PF01032, Bacterial transport system permease, score 4.8e-85 40041001924 9 probable transmembrane helices predicted for SZO03510 by TMHMM2.0 at aa 7-29, 57-79, 92-109, 119-141, 148-170, 198-220, 241-263, 283-305 and 312-329 40041001925 PS00215 Mitochondrial energy transfer proteins signature. 40041001926 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 40041001927 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 40041001928 ABC-ATPase subunit interface; other site 40041001929 dimer interface [polypeptide binding]; other site 40041001930 putative PBP binding regions; other site 40041001931 HMMPfam hit to PF01032, Bacterial transport system permease, score 2.1e-97 40041001932 10 probable transmembrane helices predicted for SZO03520 by TMHMM2.0 at aa 19-41, 68-90, 103-122, 126-148, 160-179, 184-201, 206-228, 243-274, 286-303 and 318-335 40041001933 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 40041001934 Periplasmic binding protein FeuA. These proteins have predicted to function as initial receptors in ABC transport of metal ions in some eubacterial species. They belong to the TroA superfamily of periplasmic metal binding proteins that share a distinct...; Region: FeuA; cd01138 40041001935 putative ligand binding residues [chemical binding]; other site 40041001936 HMMPfam hit to PF01497, Periplasmic binding protein, score 3.5e-40 40041001937 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 40041001938 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 40041001939 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 40041001940 Walker A/P-loop; other site 40041001941 ATP binding site [chemical binding]; other site 40041001942 Q-loop/lid; other site 40041001943 ABC transporter signature motif; other site 40041001944 Walker B; other site 40041001945 D-loop; other site 40041001946 H-loop/switch region; other site 40041001947 HMMPfam hit to PF00005, ABC transporter related, score 5.1e-50 40041001948 PS00211 ABC transporters family signature. 40041001949 PS00017 ATP/GTP-binding site motif A (P-loop). 40041001950 UDP-N-acetylmuramoylalanyl-D-glutamate--L-lysine ligase; Provisional; Region: PRK14022 40041001951 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 40041001952 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 40041001953 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 40041001954 HMMPfam hit to PF02875, Mur ligase, C-terminal, score 1.7e-18 40041001955 PS00030 Eukaryotic RNA-binding region RNP-1 signature. 40041001956 HMMPfam hit to PF08245, Mur ligase, central, score 1.2e-34 40041001957 HMMPfam hit to PF01225, Mur ligase, N-terminal, score 0.0041 40041001958 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 40041001959 Stage V sporulation protein B, also known as Stage III sporulation protein F, and related proteins; Region: MATE_SpoVB_like; cd13124 40041001960 HMMPfam hit to PF01943, Polysaccharide biosynthesis protein, score 1.1e-09 40041001961 12 probable transmembrane helices predicted for SZO03560 by TMHMM2.0 at aa 21-43, 58-77, 98-117, 132-154, 194-216, 302-324, 336-358, 373-395, 407-426, 431-448, 468-490 and 500-522 40041001962 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 40041001963 active site 40041001964 HMMPfam hit to PF00156, Phosphoribosyltransferase, score 4.3e-15 40041001965 Protease subunit of ATP-dependent Clp proteases [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: ClpP; COG0740 40041001966 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 40041001967 oligomer interface [polypeptide binding]; other site 40041001968 active site residues [active] 40041001969 HMMPfam hit to PF00574, Peptidase S14, ClpP, score 5.4e-120 40041001970 PS00381 Endopeptidase Clp serine active site. 40041001971 PS00382 Endopeptidase Clp histidine active site. 40041001972 Protein of unknown function (DUF964); Region: DUF964; pfam06133 40041001973 HMMPfam hit to PF07050, Protein of unknown function DUF1333, score 1.1e-21 40041001974 hypothetical protein; Provisional; Region: PRK02302 40041001975 thymidylate kinase; Validated; Region: tmk; PRK00698 40041001976 Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672 40041001977 TMP-binding site; other site 40041001978 ATP-binding site [chemical binding]; other site 40041001979 HMMPfam hit to PF02223, Thymidylate kinase, score 3.2e-66 40041001980 PS00017 ATP/GTP-binding site motif A (P-loop). 40041001981 PS01331 Thymidylate kinase signature. 40041001982 DNA polymerase III subunit delta'; Validated; Region: PRK07276 40041001983 DNA polymerase III subunit delta'; Validated; Region: PRK08485 40041001984 PSP1 C-terminal conserved region; Region: PSP1; cl00770 40041001985 HMMPfam hit to PF04468, PSP1 C-terminal conserved region, score 3.7e-26 40041001986 DNA replication intiation control protein YabA; Reviewed; Region: PRK13169 40041001987 HMMPfam hit to PF06156, Protein of unknown function DUF972, score 7.8e-63 40041001988 Predicted methyltransferases [General function prediction only]; Region: COG0313 40041001989 Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648 40041001990 putative SAM binding site [chemical binding]; other site 40041001991 putative homodimer interface [polypeptide binding]; other site 40041001992 HMMPfam hit to PF00590, Tetrapyrrole methylase, score 7.7e-40 40041001993 PS01296 Uncharacterized protein family UPF0011 signature. 40041001994 Probable gene remnant. Similar to internal region of Streptococcus sanguinis (strain SK36) transposase UniProt:A3CNW8 (EMBL:CP000387) (209 aa) fasta scores: E()=1.8e-05, 41.250% id in 80 aa, and to Streptococcus sanguinis (strain SK36) transposase, . UniProt:A3CNW8 (EMBL:CP000387) (209 aa) fasta scores: E()=1.8e-05, 41.250% id in 80 aa 40041001995 2 probable transmembrane helices predicted for SZO03670 by TMHMM2.0 at aa 2-19 and 29-63 40041001996 Predicted membrane protein [Function unknown]; Region: COG3212 40041001997 Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413 40041001998 Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413 40041001999 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 40041002000 HMMPfam hit to PF03413, Peptidase M4, propeptide, PepSY, score 0.0004 40041002001 HMMPfam hit to PF03413, Peptidase M4, propeptide, PepSY, score 0.0015 40041002002 glycerol kinase; Provisional; Region: glpK; PRK00047 40041002003 Escherichia coli glycerol kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_EcGK_like; cd07786 40041002004 N- and C-terminal domain interface [polypeptide binding]; other site 40041002005 active site 40041002006 MgATP binding site [chemical binding]; other site 40041002007 catalytic site [active] 40041002008 metal binding site [ion binding]; metal-binding site 40041002009 glycerol binding site [chemical binding]; other site 40041002010 homotetramer interface [polypeptide binding]; other site 40041002011 homodimer interface [polypeptide binding]; other site 40041002012 FBP binding site [chemical binding]; other site 40041002013 protein IIAGlc interface [polypeptide binding]; other site 40041002014 HMMPfam hit to PF00370, Carbohydrate kinase, FGGY, score 1.1e-116 40041002015 PS00933 FGGY family of carbohydrate kinases signature 1. 40041002016 HMMPfam hit to PF02782, Carbohydrate kinase, FGGY, score 3.2e-77 40041002017 PS00445 FGGY family of carbohydrate kinases signature 2. 40041002018 PS00014 Endoplasmic reticulum targeting sequence. 40041002019 Transaldolase-like fructose-6-phosphate aldolases (FSA) found in bacteria and archaea; Region: Transaldolase_FSA; cd00956 40041002020 active site 40041002021 intersubunit interactions; other site 40041002022 catalytic residue [active] 40041002023 HMMPfam hit to PF00923, Transaldolase, score 9.7e-53 40041002024 PS01054 Transaldolase signature 1. 40041002025 Transketolase [Carbohydrate transport and metabolism]; Region: TktA; COG0021 40041002026 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 40041002027 TPP-binding site [chemical binding]; other site 40041002028 dimer interface [polypeptide binding]; other site 40041002029 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 40041002030 PYR/PP interface [polypeptide binding]; other site 40041002031 dimer interface [polypeptide binding]; other site 40041002032 TPP binding site [chemical binding]; other site 40041002033 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 40041002034 HMMPfam hit to PF00456, Transketolase, N-terminal, score 3.2e-206 40041002035 PS00801 Transketolase signature 1. 40041002036 HMMPfam hit to PF02779, Transketolase, central region, score 3.8e-66 40041002037 PS00802 Transketolase signature 2. 40041002038 HMMPfam hit to PF02780, Transketolase, C-terminal, score 0.0026 40041002039 Collagen triple helix repeat (20 copies); Region: Collagen; pfam01391 40041002040 Gram positive anchor; Region: Gram_pos_anchor; pfam00746 40041002041 HMMPfam hit to PF00746, Surface protein from Gram-positive cocci, anchor region, score 3.2e-11 40041002042 PS00343 Gram-positive cocci surface proteins 'anchoring' hexapeptide. 40041002043 HMMPfam hit to PF01391, Collagen triple helix repeat, score 8.6e-10 40041002044 HMMPfam hit to PF01391, Collagen triple helix repeat, score 3.6e-17 40041002045 HMMPfam hit to PF01391, Collagen triple helix repeat, score 4.7e-14 40041002046 HMMPfam hit to PF01391, Collagen triple helix repeat, score 1.8e-06 40041002047 1 probable transmembrane helix predicted for SZO03720 by TMHMM2.0 at aa 9-31 40041002048 Enterocin A Immunity; Region: EntA_Immun; pfam08951 40041002049 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 40041002050 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 40041002051 Walker A/P-loop; other site 40041002052 ATP binding site [chemical binding]; other site 40041002053 Q-loop/lid; other site 40041002054 ABC transporter signature motif; other site 40041002055 Walker B; other site 40041002056 D-loop; other site 40041002057 H-loop/switch region; other site 40041002058 HMMPfam hit to PF00005, ABC transporter related, score 1.1e-43 40041002059 PS00017 ATP/GTP-binding site motif A (P-loop). 40041002060 PS00211 ABC transporters family signature. 40041002061 12 probable transmembrane helices predicted for SZO03750 by TMHMM2.0 at aa 48-65, 75-97, 125-147, 152-174, 190-212, 248-267, 319-341, 356-378, 407-429, 433-455, 479-501 and 511-531 40041002062 PS00095 C-5 cytosine-specific DNA methylases C-terminal signature. 40041002063 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 40041002064 1 probable transmembrane helix predicted for SZO03760 by TMHMM2.0 at aa 7-26 40041002065 Glutamate 5-kinase [Amino acid transport and metabolism]; Region: ProB; COG0263 40041002066 AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242 40041002067 nucleotide binding site [chemical binding]; other site 40041002068 homotetrameric interface [polypeptide binding]; other site 40041002069 putative phosphate binding site [ion binding]; other site 40041002070 putative allosteric binding site; other site 40041002071 HMMPfam hit to PF00696, Aspartate/glutamate/uridylate kinase, score 4.5e-61 40041002072 Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079 40041002073 gamma-glutamyl phosphate reductase; Region: proA; TIGR00407 40041002074 putative catalytic cysteine [active] 40041002075 Predicted S-adenosylmethionine-dependent methyltransferase involved in cell envelope biogenesis [Cell envelope biogenesis, outer membrane]; Region: COG0275 40041002076 MraW methylase family; Region: Methyltransf_5; pfam01795 40041002077 HMMPfam hit to PF01795, Bacterial methyltransferase, score 8.2e-192 40041002078 Protein required for the initiation of cell division [Cell division and chromosome partitioning]; Region: FtsL; COG4839 40041002079 1 probable transmembrane helix predicted for SZO03810 by TMHMM2.0 at aa 27-46 40041002080 HMMPfam hit to PF04977, Septum formation initiator, score 0.00019 40041002081 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 40041002082 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 40041002083 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 40041002084 PASTA domain of PBP2x-like proteins, first repeat. Penicillin-binding proteins (PBPs) are the major targets for beta-lactam antibiotics, like penicillins and cephalosporins. Beta-lactam antibiotics specifically inhibit transpeptidase activity by...; Region: PASTA_Pbp2x-like_1; cd06576 40041002085 PASTA domain of PBP2x-like proteins, second repeat. Penicillin-binding proteins (PBPs) are the major targets for beta-lactam antibiotics, like penicillins and cephalosporins. Beta-lactam antibiotics specifically inhibit transpeptidase activity by...; Region: PASTA_Pbp2x-like_2; cd06575 40041002086 PS00430 TonB-dependent receptor proteins signature 1. 40041002087 1 probable transmembrane helix predicted for SZO03820 by TMHMM2.0 at aa 26-48 40041002088 HMMPfam hit to PF03717, Penicillin-binding protein, dimerisation domain, score 1.4e-45 40041002089 HMMPfam hit to PF00905, Penicillin-binding protein, transpeptidase, score 1.2e-90 40041002090 HMMPfam hit to PF03793, PASTA, score 6.8e-07 40041002091 HMMPfam hit to PF03793, PASTA, score 1.4e-10 40041002092 phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108 40041002093 Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852 40041002094 Mg++ binding site [ion binding]; other site 40041002095 putative catalytic motif [active] 40041002096 putative substrate binding site [chemical binding]; other site 40041002097 10 probable transmembrane helices predicted for SZO03830 by TMHMM2.0 at aa 4-26, 47-69, 79-98, 119-138, 148-170, 177-196, 200-219, 226-248, 252-274 and 317-334 40041002098 HMMPfam hit to PF00953, Glycosyl transferase, family 4, score 8.9e-61 40041002099 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 40041002100 DEAD-like helicases superfamily; Region: DEXDc; smart00487 40041002101 ATP binding site [chemical binding]; other site 40041002102 Mg++ binding site [ion binding]; other site 40041002103 motif III; other site 40041002104 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 40041002105 nucleotide binding region [chemical binding]; other site 40041002106 ATP-binding site [chemical binding]; other site 40041002107 HMMPfam hit to PF00270, DNA/RNA helicase, DEAD/DEAH box type, N-terminal, score 9.7e-55 40041002108 HMMPfam hit to PF00271, DNA/RNA helicase, C-terminal, score 1.3e-27 40041002109 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 40041002110 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 40041002111 substrate binding pocket [chemical binding]; other site 40041002112 membrane-bound complex binding site; other site 40041002113 hinge residues; other site 40041002114 HMMPfam hit to PF00497, Bacterial extracellular solute-binding protein, family 3, score 9.3e-50 40041002115 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 40041002116 dimer interface [polypeptide binding]; other site 40041002117 conserved gate region; other site 40041002118 putative PBP binding loops; other site 40041002119 ABC-ATPase subunit interface; other site 40041002120 HMMPfam hit to PF00528, Binding-protein-dependent transport systems inner membrane component, score 1.2e-17 40041002121 3 probable transmembrane helices predicted for SZO03870 by TMHMM2.0 at aa 44-66, 79-101 and 116-138 40041002122 PS00402 Binding-protein-dependent transport systems inner membrane comp. sign. 40041002123 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 40041002124 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 40041002125 Walker A/P-loop; other site 40041002126 ATP binding site [chemical binding]; other site 40041002127 Q-loop/lid; other site 40041002128 ABC transporter signature motif; other site 40041002129 Walker B; other site 40041002130 D-loop; other site 40041002131 H-loop/switch region; other site 40041002132 HMMPfam hit to PF00005, ABC transporter related, score 1.3e-66 40041002133 PS00017 ATP/GTP-binding site motif A (P-loop). 40041002134 PS00211 ABC transporters family signature. 40041002135 Protein of unknown function (DUF4059); Region: DUF4059; pfam13268 40041002136 2 probable transmembrane helices predicted for SZO03890 by TMHMM2.0 at aa 13-30 and 50-72 40041002137 thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292 40041002138 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 40041002139 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 40041002140 HMMPfam hit to PF07992, FAD-dependent pyridine nucleotide-disulphide oxidoreductase, score 2.6e-41 40041002141 PS00573 Pyridine nucleotide-disulphide oxidoreductases class-II active site. 40041002142 HMMPfam hit to PF00070, Pyridine nucleotide-disulphide oxidoreductase, NAD-binding region, score 3e-26 40041002143 Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113 40041002144 HMMPfam hit to PF00324, Amino acid permease-associated region, score 3.8e-89 40041002145 12 probable transmembrane helices predicted for SZO03910 by TMHMM2.0 at aa 26-48, 53-72, 92-114, 129-151, 158-180, 210-232, 252-270, 290-312, 342-364, 374-396, 409-431 and 436-453 40041002146 PS00218 Amino acid permeases signature. 40041002147 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 40041002148 nicotinate phosphoribosyltransferase; Validated; Region: PRK09243 40041002149 Nicotinate phosphoribosyltransferase (NAPRTase), subgroup A. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting, reaction...; Region: NAPRTase_A; cd01570 40041002150 active site 40041002151 HMMPfam hit to PF04095, Nicotinate phosphoribosyltransferase-like, score 3.8e-10 40041002152 NAD synthase [Coenzyme metabolism]; Region: NadE; COG0171 40041002153 NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553 40041002154 homodimer interface [polypeptide binding]; other site 40041002155 NAD binding pocket [chemical binding]; other site 40041002156 ATP binding pocket [chemical binding]; other site 40041002157 Mg binding site [ion binding]; other site 40041002158 active-site loop [active] 40041002159 HMMPfam hit to PF02540, NAD+ synthase, score 7.8e-100 40041002160 Peptidase C1B subfamily (MEROPS database nomenclature); composed of eukaryotic bleomycin hydrolases (BH) and bacterial aminopeptidases C (pepC). The proteins of this subfamily contain a large insert relative to the C1A peptidase (papain) subfamily. BH is...; Region: Peptidase_C1B; cd00585 40041002161 trimer interface [polypeptide binding]; other site 40041002162 active site 40041002163 G bulge; other site 40041002164 HMMPfam hit to PF03051, Peptidase C1B, bleomycin hydrolase, score 1.8e-299 40041002165 PS00139 Eukaryotic thiol (cysteine) proteases cysteine active site. 40041002166 PS00017 ATP/GTP-binding site motif A (P-loop). 40041002167 PS00639 Eukaryotic thiol (cysteine) proteases histidine active site. 40041002168 Membrane carboxypeptidase (penicillin-binding protein) [Cell envelope biogenesis, outer membrane]; Region: MrcB; COG0744 40041002169 Transglycosylase; Region: Transgly; pfam00912 40041002170 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 40041002171 HMMPfam hit to PF00905, Penicillin-binding protein, transpeptidase, score 8.4e-20 40041002172 PS00017 ATP/GTP-binding site motif A (P-loop). 40041002173 HMMPfam hit to PF00912, Glycosyl transferase, family 51, score 7.6e-84 40041002174 1 probable transmembrane helix predicted for SZO03950 by TMHMM2.0 at aa 17-39 40041002175 Holliday junction-specific endonuclease; Reviewed; Region: recU; PRK02234 40041002176 HMMPfam hit to PF03838, Recombination protein U, score 4e-119 40041002177 PS00030 Eukaryotic RNA-binding region RNP-1 signature. 40041002178 hypothetical protein; Provisional; Region: PRK13660 40041002179 HMMPfam hit to PF06908, Protein of unknown function DUF1273, score 8.2e-106 40041002180 cell division protein GpsB; Provisional; Region: PRK14127 40041002181 DivIVA domain; Region: DivI1A_domain; TIGR03544 40041002182 HMMPfam hit to PF05103, DivIVA, score 1e-27 40041002183 Predicted N6-adenine-specific DNA methylase [DNA replication, recombination, and repair]; Region: COG0116 40041002184 THUMP domain associated with S-adenosylmethionine-dependent methyltransferases; Region: THUMP_AdoMetMT; cd11715 40041002185 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 40041002186 HMMPfam hit to PF01170, RNA methylase, score 1.6e-63 40041002187 PS00092 N-6 Adenine-specific DNA methylases signature. 40041002188 1 probable transmembrane helix predicted for SZO04000 by TMHMM2.0 at aa 168-190 40041002189 S-ribosylhomocysteinase; Provisional; Region: PRK02260 40041002190 HMMPfam hit to PF02664, S-ribosylhomocysteinase (LuxS), score 5.1e-46 40041002191 hypothetical protein; Provisional; Region: PRK00106 40041002192 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 40041002193 Zn2+ binding site [ion binding]; other site 40041002194 Mg2+ binding site [ion binding]; other site 40041002195 1 probable transmembrane helix predicted for SZO04020 by TMHMM2.0 at aa 2-24 40041002196 HMMPfam hit to PF00013, K Homology, type 1, score 4.4e-10 40041002197 HMMPfam hit to PF01966, Metal-dependent phosphohydrolase, HD region, subdomain, score 6.8e-24 40041002198 Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194 40041002199 Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071 40041002200 catalytic site [active] 40041002201 G-X2-G-X-G-K; other site 40041002202 HMMPfam hit to PF00625, Guanylate kinase, score 8.1e-46 40041002203 DNA-directed RNA polymerase subunit omega; Reviewed; Region: rpoZ; PRK00392 40041002204 HMMPfam hit to PF01192, RNA polymerase Rpb6, score 2.6e-14 40041002205 Primosomal protein N' (replication factor Y) - superfamily II helicase [DNA replication, recombination, and repair]; Region: PriA; COG1198 40041002206 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 40041002207 ATP binding site [chemical binding]; other site 40041002208 putative Mg++ binding site [ion binding]; other site 40041002209 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 40041002210 ATP-binding site [chemical binding]; other site 40041002211 HMMPfam hit to PF04851, Restriction endonuclease, type I, R subunit/Type III, Res subunit, score 4e-28 40041002212 PS00017 ATP/GTP-binding site motif A (P-loop). 40041002213 HMMPfam hit to PF00271, DNA/RNA helicase, C-terminal, score 7.5e-10 40041002214 methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005 40041002215 Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646 40041002216 putative active site [active] 40041002217 substrate binding site [chemical binding]; other site 40041002218 putative cosubstrate binding site; other site 40041002219 catalytic site [active] 40041002220 C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704 40041002221 substrate binding site [chemical binding]; other site 40041002222 HMMPfam hit to PF00551, Formyl transferase, N-terminal, score 1.8e-37 40041002223 HMMPfam hit to PF02911, Formyl transferase, C-terminal, score 2.3e-35 40041002224 16S rRNA methyltransferase B; Provisional; Region: PRK14902 40041002225 NusB family; Region: NusB; pfam01029 40041002226 putative RNA binding site [nucleotide binding]; other site 40041002227 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 40041002228 S-adenosylmethionine binding site [chemical binding]; other site 40041002229 HMMPfam hit to PF01029, NusB/RsmB/TIM44, score 1.6e-29 40041002230 HMMPfam hit to PF01189, Bacterial Fmu (Sun)/eukaryotic nucleolar NOL1/Nop2p, score 3.8e-48 40041002231 PS01153 NOL1/NOP2/sun family signature. 40041002232 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143 40041002233 active site 40041002234 HMMPfam hit to PF00481, Protein phosphatase 2C, N-terminal, score 3.9e-07 40041002235 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 40041002236 Catalytic domain of Protein Kinases; Region: PKc; cd00180 40041002237 active site 40041002238 ATP binding site [chemical binding]; other site 40041002239 substrate binding site [chemical binding]; other site 40041002240 activation loop (A-loop); other site 40041002241 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2815 40041002242 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 40041002243 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 40041002244 PASTA domain; Region: PASTA; pfam03793 40041002245 HMMPfam hit to PF00069, Protein kinase, core, score 1.5e-59 40041002246 PS00107 Protein kinases ATP-binding region signature. 40041002247 PS00108 Serine/Threonine protein kinases active-site signature. 40041002248 1 probable transmembrane helix predicted for SZO04090 by TMHMM2.0 at aa 342-364 40041002249 HMMPfam hit to PF03793, PASTA, score 8.9e-11 40041002250 HMMPfam hit to PF03793, PASTA, score 8.9e-10 40041002251 HMMPfam hit to PF03793, PASTA, score 7.7e-09 40041002252 Predicted membrane protein [Function unknown]; Region: COG4758 40041002253 Cell wall-active antibiotics response protein (DUF2154); Region: DUF2154; pfam09922 40041002254 3 probable transmembrane helices predicted for SZO04100 by TMHMM2.0 at aa 7-24, 28-45 and 52-84 40041002255 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 40041002256 Histidine kinase; Region: HisKA_3; pfam07730 40041002257 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 40041002258 ATP binding site [chemical binding]; other site 40041002259 Mg2+ binding site [ion binding]; other site 40041002260 G-X-G motif; other site 40041002261 2 probable transmembrane helices predicted for SZO04110 by TMHMM2.0 at aa 7-25 and 45-67 40041002262 HMMPfam hit to PF07730, Histidine kinase, dimerisation and phosphoacceptor region, score 1.1e-22 40041002263 HMMPfam hit to PF02518, ATP-binding region, ATPase-like, score 1.3e-14 40041002264 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 40041002265 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 40041002266 active site 40041002267 phosphorylation site [posttranslational modification] 40041002268 intermolecular recognition site; other site 40041002269 dimerization interface [polypeptide binding]; other site 40041002270 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 40041002271 DNA binding residues [nucleotide binding] 40041002272 dimerization interface [polypeptide binding]; other site 40041002273 HMMPfam hit to PF00072, Response regulator receiver, score 2.4e-30 40041002274 HMMPfam hit to PF00196, Bacterial regulatory protein, LuxR, score 1.9e-23 40041002275 PS00622 Bacterial regulatory proteins, luxR family signature. 40041002276 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 40041002277 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 40041002278 active site 40041002279 motif I; other site 40041002280 motif II; other site 40041002281 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 40041002282 Peptidyl-prolyl cis-trans isomerase (rotamase) - cyclophilin family [Posttranslational modification, protein turnover, chaperones]; Region: PpiB; COG0652 40041002283 active site 40041002284 HMMPfam hit to PF08282, HAD superfamily hydrolase-like, type 3, score 1.2e-62 40041002285 HMMPfam hit to PF00160, Peptidyl-prolyl cis-trans isomerase, cyclophilin-type, score 6.4e-53 40041002286 PS00170 Cyclophilin-type peptidyl-prolyl cis-trans isomerase signature. 40041002287 hypothetical protein; Provisional; Region: PRK07252 40041002288 Predicted RNA binding protein (contains ribosomal protein S1 domain) [Translation, ribosomal structure and biogenesis]; Region: VacB; COG1098 40041002289 RNA binding site [nucleotide binding]; other site 40041002290 HMMPfam hit to PF00575, S1, RNA binding, score 5.8e-15 40041002291 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 40041002292 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 40041002293 dimer interface [polypeptide binding]; other site 40041002294 pyridoxal 5'-phosphate binding site [chemical binding]; other site 40041002295 catalytic residue [active] 40041002296 HMMPfam hit to PF00291, Pyridoxal phosphate-dependent enzyme, beta subunit, score 1e-115 40041002297 PS00901 Cysteine synthase/cystathionine beta-synthase P-phosphate attachment site. 40041002298 Uncharacterized conserved protein [Function unknown]; Region: COG1739 40041002299 Uncharacterized protein family UPF0029; Region: UPF0029; pfam01205 40041002300 Domain of unknown function (DUF1949); Region: DUF1949; pfam09186 40041002301 HMMPfam hit to PF01205, Protein of unknown function UPF0029, N-terminal, score 2.2e-57 40041002302 PS00910 Uncharacterized protein family UPF0029 signature. 40041002303 Superfamily II DNA/RNA helicase required for DNA uptake (late competence protein) [DNA replication, recombination, and repair]; Region: comFA; COG4098 40041002304 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 40041002305 ATP binding site [chemical binding]; other site 40041002306 putative Mg++ binding site [ion binding]; other site 40041002307 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 40041002308 nucleotide binding region [chemical binding]; other site 40041002309 ATP-binding site [chemical binding]; other site 40041002310 PS00017 ATP/GTP-binding site motif A (P-loop). 40041002311 HMMPfam hit to PF00271, DNA/RNA helicase, C-terminal, score 3.7e-12 40041002312 Predicted amidophosphoribosyltransferases [General function prediction only]; Region: ComFC; COG1040 40041002313 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 40041002314 active site 40041002315 PS00190 Cytochrome c family heme-binding site signature. 40041002316 RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552 40041002317 30S subunit binding site; other site 40041002318 HMMPfam hit to PF02482, Ribosomal protein S30Ae/sigma 54 modulation protein, score 7.6e-31 40041002320 Staphylococcal protein of unknown function (DUF960); Region: DUF960; pfam06124 40041002321 hypothetical protein; Provisional; Region: PRK13662 40041002322 HMMPfam hit to PF04167, Protein of unknown function DUF402, score 1.3e-40 40041002323 recombination regulator RecX; Provisional; Region: recX; PRK14135 40041002324 HMMPfam hit to PF02631, Regulatory protein RecX, score 7.2e-06 40041002325 PS00017 ATP/GTP-binding site motif A (P-loop). 40041002326 type I site-specific deoxyribonuclease, HsdR family; Region: hsdR; TIGR00348 40041002327 Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; pfam04313 40041002328 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 40041002329 ATP binding site [chemical binding]; other site 40041002330 putative Mg++ binding site [ion binding]; other site 40041002331 HMMPfam hit to PF04851, Restriction endonuclease, type I, R subunit/Type III, Res subunit, score 1.8e-08 40041002332 HMMPfam hit to PF04313, Restriction endonuclease, type I, EcoRI, R subunit/Type III, Res subunit, N terminus, score 2.9e-07 40041002333 Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732 40041002334 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 40041002335 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 40041002336 HsdM N-terminal domain; Region: HsdM_N; pfam12161 40041002337 N-6 DNA Methylase; Region: N6_Mtase; pfam02384 40041002338 Methyltransferase domain; Region: Methyltransf_26; pfam13659 40041002339 HMMPfam hit to PF02384, N-6 DNA methylase, score 2.8e-43 40041002340 PS00092 N-6 Adenine-specific DNA methylases signature. 40041002341 Similar to the C-terminal region of Clostridium difficile TndX UniProt:Q9KJA1 (EMBL:AF333235) (533 aa) fasta scores: E()=1.9e-23, 29.605% id in 304 aa 40041002342 Predicted helix-turn-helix motif with score 1096.000, SD 2.92 at aa 293-314, sequence WTTQELLDIPGVGKQMIARLKR 40041002343 TRAM domain; Region: TRAM; pfam01938 40041002344 SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase [Translation, ribosomal structure and biogenesis]; Region: TrmA; COG2265 40041002345 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 40041002346 S-adenosylmethionine binding site [chemical binding]; other site 40041002347 HMMPfam hit to PF01938, Deoxyribonuclease/rho motif-related TRAM, score 1e-08 40041002348 HMMPfam hit to PF05958, (Uracil-5)-methyltransferase, score 2.9e-06 40041002349 PS01230 RNA methyltransferase trmA family signature 1. 40041002350 PS00071 Glyceraldehyde 3-phosphate dehydrogenase active site. 40041002351 Bacteriocin class II with double-glycine leader peptide; Region: Bacteriocin_IIc; pfam10439 40041002352 2 probable transmembrane helices predicted for SZO04310 by TMHMM2.0 at aa 34-56 and 60-82 40041002353 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 40041002354 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 40041002355 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 40041002356 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 40041002357 active site 40041002358 phosphorylation site [posttranslational modification] 40041002359 intermolecular recognition site; other site 40041002360 dimerization interface [polypeptide binding]; other site 40041002361 LytTr DNA-binding domain; Region: LytTR; pfam04397 40041002362 HMMPfam hit to PF00072, Response regulator receiver, score 8.7e-07 40041002363 HMMPfam hit to PF04397, LytTr DNA-binding region, score 2.4e-28 40041002364 Predicted signal transduction protein with a C-terminal ATPase domain [Signal transduction mechanisms]; Region: COG2972 40041002365 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 40041002366 ATP binding site [chemical binding]; other site 40041002367 Mg2+ binding site [ion binding]; other site 40041002368 G-X-G motif; other site 40041002369 7 probable transmembrane helices predicted for SZO04340 by TMHMM2.0 at aa 4-22, 29-51, 55-77, 84-106, 121-142, 162-181 and 191-210 40041002370 HMMPfam hit to PF02518, ATP-binding region, ATPase-like, score 6.4e-05 40041002371 bacteriocin secretion accessory protein; Region: bacteriocin_acc; TIGR01000 40041002372 HlyD family secretion protein; Region: HlyD_3; pfam13437 40041002373 1 probable transmembrane helix predicted for SZO04350 by TMHMM2.0 at aa 19-41 40041002374 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 40041002375 A sub-family of peptidase family C39. Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various...; Region: Peptidase_C39B; cd02418 40041002376 ABC-type bacteriocin transporter; Region: bacteriocin_ABC; TIGR01193 40041002377 putative active site [active] 40041002378 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 40041002379 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 40041002380 Walker A/P-loop; other site 40041002381 ATP binding site [chemical binding]; other site 40041002382 Q-loop/lid; other site 40041002383 ABC transporter signature motif; other site 40041002384 Walker B; other site 40041002385 D-loop; other site 40041002386 H-loop/switch region; other site 40041002387 HMMPfam hit to PF00005, ABC transporter related, score 6.6e-53 40041002388 PS00211 ABC transporters family signature. 40041002389 PS00017 ATP/GTP-binding site motif A (P-loop). 40041002390 HMMPfam hit to PF00664, ABC transporter, transmembrane region, score 2.1e-63 40041002391 4 probable transmembrane helices predicted for SZO04360 by TMHMM2.0 at aa 168-190, 202-224, 279-301 and 308-330 40041002392 HMMPfam hit to PF03412, Peptidase C39, bacteriocin processing, score 5.4e-62 40041002393 Enterocin A Immunity; Region: EntA_Immun; pfam08951 40041002394 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 40041002395 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 40041002396 1 probable transmembrane helix predicted for SZO04400 by TMHMM2.0 at aa 41-63 40041002397 2 probable transmembrane helices predicted for SZO04410 by TMHMM2.0 at aa 5-20 and 41-63 40041002398 4 probable transmembrane helices predicted for SZO04420 by TMHMM2.0 at aa 7-29, 39-61, 74-96 and 106-128 40041002399 Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247 40041002400 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 40041002401 Coenzyme A binding pocket [chemical binding]; other site 40041002402 HMMPfam hit to PF00583, GCN5-related N-acetyltransferase, score 3.9e-11 40041002403 Ortholog of S. equi 4047 (FM204883) SEQ1699; CDS contains a nonsense mutation (opal) after codon 6 40041002404 bacteriocin-associated integral membrane (putative immunity) protein; Region: bact_immun_7tm; TIGR01654 40041002405 8 probable transmembrane helices predicted for SZO04440 by TMHMM2.0 at aa 5-23, 150-172, 193-215, 225-247, 267-289, 558-580, 600-622 and 627-649 40041002406 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 40041002407 putative bacteriocin export ABC transporter, lactococcin 972 group; Region: L_ocin_972_ABC; TIGR03608 40041002408 Walker A/P-loop; other site 40041002409 ATP binding site [chemical binding]; other site 40041002410 Q-loop/lid; other site 40041002411 ABC transporter signature motif; other site 40041002412 Walker B; other site 40041002413 D-loop; other site 40041002414 H-loop/switch region; other site 40041002415 HMMPfam hit to PF00005, ABC transporter related, score 2.2e-50 40041002416 PS00017 ATP/GTP-binding site motif A (P-loop). 40041002417 PS00211 ABC transporters family signature. 40041002418 PS00294 Prenyl group binding site (CAAX box). 40041002419 Alpha-mannosidase [Carbohydrate transport and metabolism]; Region: AMS1; COG0383 40041002420 N-terminal catalytic domain of SPGH38, a putative alpha-mannosidase of Streptococcus pyogenes, and its prokaryotic homologs; glycoside hydrolase family 38 (GH38); Region: GH38N_AMII_SpGH38_like; cd10814 40041002421 active site 40041002422 metal binding site [ion binding]; metal-binding site 40041002423 homodimer interface [polypeptide binding]; other site 40041002424 catalytic site [active] 40041002425 Alpha mannosidase, middle domain; Region: Alpha-mann_mid; smart00872 40041002426 HMMPfam hit to PF07748, Glycosyl hydrolases 38, C-terminal, score 1e-07 40041002427 HMMPfam hit to PF01074, Glycoside hydrolase, family 38, core, score 1.2e-30 40041002428 Uncharacterized conserved protein [Function unknown]; Region: COG3538 40041002429 Protein of unknown function (DUF1237); Region: DUF1237; pfam06824 40041002430 HMMPfam hit to PF06824, Uncharacterised conserved protein UCP028846, score 0 40041002431 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 40041002432 DNA-binding site [nucleotide binding]; DNA binding site 40041002433 Transcriptional regulators [Transcription]; Region: PurR; COG1609 40041002434 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 40041002435 ligand binding site [chemical binding]; other site 40041002436 dimerization interface [polypeptide binding]; other site 40041002437 HMMPfam hit to PF00392, Bacterial regulatory protein GntR, HTH, score 3.8e-24 40041002438 HMMPfam hit to PF00532, Periplasmic binding protein/LacI transcriptional regulator, score 3.8e-05 40041002439 beta-N-acetylglucosaminidase; Region: NAGidase; pfam07555 40041002440 HMMPfam hit to PF07555, Hyaluronidase eukaryotic/prokaryotic, score 9.9e-160 40041002441 Beta-glucosidase/6-phospho-beta-glucosidase/beta- galactosidase [Carbohydrate transport and metabolism]; Region: BglB; COG2723 40041002442 beta-galactosidase; Region: BGL; TIGR03356 40041002443 HMMPfam hit to PF00232, Glycoside hydrolase, family 1, score 6.5e-97 40041002444 Putative alpha-1,2-mannosidase [Carbohydrate transport and metabolism]; Region: COG3537 40041002445 Glycosyl hydrolase family 92; Region: Glyco_hydro_92; pfam07971 40041002446 HMMPfam hit to PF07971, Glycosyl hydrolase 92, score 1e-200 40041002447 PS00343 Gram-positive cocci surface proteins 'anchoring' hexapeptide. 40041002448 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 40041002449 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 40041002450 nucleotide binding site [chemical binding]; other site 40041002451 HMMPfam hit to PF00480, ROK, score 1.8e-30 40041002452 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 40041002453 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 40041002454 ABC-ATPase subunit interface; other site 40041002455 6 probable transmembrane helices predicted for SZO04540 by TMHMM2.0 at aa 20-42, 88-110, 123-145, 175-197, 221-243 and 284-306 40041002456 HMMPfam hit to PF00528, Binding-protein-dependent transport systems inner membrane component, score 9.3e-10 40041002457 PS00402 Binding-protein-dependent transport systems inner membrane comp. sign. 40041002458 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 40041002459 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 40041002460 dimer interface [polypeptide binding]; other site 40041002461 conserved gate region; other site 40041002462 putative PBP binding loops; other site 40041002463 ABC-ATPase subunit interface; other site 40041002464 6 probable transmembrane helices predicted for SZO04550 by TMHMM2.0 at aa 21-43, 85-107, 120-142, 152-174, 195-217 and 274-293 40041002465 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 40041002466 HMMPfam hit to PF00528, Binding-protein-dependent transport systems inner membrane component, score 7.7e-09 40041002467 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 40041002468 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 40041002469 Domain of unknown function (DUF3502); Region: DUF3502; pfam12010 40041002470 HMMPfam hit to PF01547, Bacterial extracellular solute-binding protein, family 1, score 4.4e-08 40041002471 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 40041002472 Predicted integral membrane protein [Function unknown]; Region: COG5578 40041002473 HMMPfam hit to PF04854, Protein of unknown function DUF624, score 3.3e-23 40041002474 5 probable transmembrane helices predicted for SZO04570 by TMHMM2.0 at aa 20-42, 71-93, 98-120, 140-162 and 169-186 40041002475 Predicted signal transduction protein with a C-terminal ATPase domain [Signal transduction mechanisms]; Region: COG2972 40041002476 HAMP (Histidine kinases, Adenylyl cyclases, Methyl binding proteins, Phosphatases) domain; Region: HAMP; smart00304 40041002477 dimerization interface [polypeptide binding]; other site 40041002478 Histidine kinase; Region: His_kinase; pfam06580 40041002479 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 40041002480 ATP binding site [chemical binding]; other site 40041002481 Mg2+ binding site [ion binding]; other site 40041002482 G-X-G motif; other site 40041002483 2 probable transmembrane helices predicted for SZO04580 by TMHMM2.0 at aa 26-48 and 283-305 40041002484 HMMPfam hit to PF00672, Histidine kinase, HAMP region, score 1.3e-08 40041002485 HMMPfam hit to PF06580, Histidine kinase internal region, score 1.6e-39 40041002486 Response regulator containing CheY-like receiver domain and AraC-type DNA-binding domain [Signal transduction mechanisms]; Region: COG4753 40041002487 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 40041002488 active site 40041002489 phosphorylation site [posttranslational modification] 40041002490 intermolecular recognition site; other site 40041002491 dimerization interface [polypeptide binding]; other site 40041002492 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 40041002493 HMMPfam hit to PF00072, Response regulator receiver, score 1.1e-31 40041002494 HMMPfam hit to PF00165, Helix-turn-helix, AraC type, score 3.3e-05 40041002495 Predicted helix-turn-helix motif with score 1202.000, SD 3.28 at aa 398-419, sequence LTLKAVSDRLHINGVYLGQCFK 40041002496 PS00041 Bacterial regulatory proteins, araC family signature. 40041002497 HMMPfam hit to PF00165, Helix-turn-helix, AraC type, score 1.1e-08 40041002498 Beta-galactosidase/beta-glucuronidase [Carbohydrate transport and metabolism]; Region: LacZ; COG3250 40041002499 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837 40041002500 Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703 40041002501 Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836 40041002502 HMMPfam hit to PF02837, Glycoside hydrolase family 2, carbohydrate-binding, score 2.1e-49 40041002503 HMMPfam hit to PF00703, Glycoside hydrolase family 2, immunoglobulin-like beta-sandwich, score 9.2e-08 40041002504 HMMPfam hit to PF02836, Glycoside hydrolase family 2, TIM barrel, score 4.2e-08 40041002505 shikimate 5-dehydrogenase; Provisional; Region: PRK12548 40041002506 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 40041002507 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 40041002508 shikimate binding site; other site 40041002509 NAD(P) binding site [chemical binding]; other site 40041002510 HMMPfam hit to PF08501, Shikimate dehydrogenase substrate binding, N-terminal, score 5.2e-44 40041002511 HMMPfam hit to PF01488, Quinate/shikimate 5-dehydrogenase/glutamyl-tRNA reductase, score 2.7e-11 40041002512 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2604 40041002513 Phosphorylase superfamily; Region: PNP_UDP_1; pfam01048 40041002514 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 40041002515 Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195 40041002516 active site 40041002517 dimer interface [polypeptide binding]; other site 40041002518 metal binding site [ion binding]; metal-binding site 40041002519 HMMPfam hit to PF01761, 3-dehydroquinate synthase AroB, score 1.2e-123 40041002520 1 probable transmembrane helix predicted for SZO04630 by TMHMM2.0 at aa 97-119 40041002521 3-deoxy-7-phosphoheptulonate synthase; Provisional; Region: PRK13397 40041002522 3-deoxy-D-arabino-heptulosonate 7-phosphate (DAHP) synthase [Amino acid transport and metabolism]; Region: AroA; COG2876 40041002523 HMMPfam hit to PF00793, DAHP synthetase I/KDSA, score 1.9e-83 40041002524 Ortholog of S. equi 4047 (FM204883) SEQ1677 40041002525 Domain of unknown function (DUF1912); Region: DUF1912; pfam08930 40041002526 HMMPfam hit to PF08930, Protein of unknown function DUF1912, score 2.5e-58 40041002527 hypothetical protein; Provisional; Region: PRK07758 40041002528 Predicted helix-turn-helix motif with score 1067.000, SD 2.82 at aa 138-159, sequence WTEAELLALKGIGPATISKLKE 40041002529 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 40041002530 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 40041002531 HMMPfam hit to PF00583, GCN5-related N-acetyltransferase, score 8.1e-13 40041002532 AAA domain; Region: AAA_18; pfam13238 40041002533 AAA domain; Region: AAA_17; pfam13207 40041002534 valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729 40041002535 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 40041002536 active site 40041002537 HIGH motif; other site 40041002538 nucleotide binding site [chemical binding]; other site 40041002539 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 40041002540 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 40041002541 active site 40041002542 KMSKS motif; other site 40041002543 Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962 40041002544 tRNA binding surface [nucleotide binding]; other site 40041002545 anticodon binding site; other site 40041002546 Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458 40041002547 HMMPfam hit to PF00133, Aminoacyl-tRNA synthetase, class Ia, score 0 40041002548 PS00178 Aminoacyl-transfer RNA synthetases class-I signature. 40041002549 HMMPfam hit to PF08264, Valyl/Leucyl/Isoleucyl-tRNA synthetase, class I, anticodon-binding, score 5.9e-60 40041002550 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 40041002551 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 40041002552 1 probable transmembrane helix predicted for SZO04710 by TMHMM2.0 at aa 5-27 40041002553 HMMPfam hit to PF03734, ErfK/YbiS/YcfS/YnhG, score 2.6e-16 40041002554 Protein of unknown function (DUF2829); Region: DUF2829; pfam11195 40041002555 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK06550 40041002556 classical (c) SDRs; Region: SDR_c; cd05233 40041002557 NAD(P) binding site [chemical binding]; other site 40041002558 active site 40041002559 HMMPfam hit to PF00106, Short-chain dehydrogenase/reductase SDR, score 9.5e-20 40041002560 PS00061 Short-chain dehydrogenases/reductases family signature. 40041002561 ASC-1 homology domain, subfamily similar to Enterococcus faecalis Ef3133. The ASCH domain, a small beta-barrel domain found in all three kingdoms of life, resembles the RNA-binding PUA domain and may also interact with RNA. ASCH has been proposed to...; Region: ASCH_Ef3133_like; cd06553 40041002562 HMMPfam hit to PF06171, Protein of unknown function DUF984, score 3.6e-66 40041002563 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 40041002564 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 40041002565 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 40041002566 HMMPfam hit to PF01408, Oxidoreductase, N-terminal, score 2.2e-30 40041002567 bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase; Provisional; Region: glmU; PRK14354 40041002568 N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540 40041002569 Substrate binding site; other site 40041002570 Mg++ binding site; other site 40041002571 N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353 40041002572 active site 40041002573 substrate binding site [chemical binding]; other site 40041002574 CoA binding site [chemical binding]; other site 40041002575 HMMPfam hit to PF01128, 4-diphosphocytidyl-2C-methyl-D-erythritol synthase, score 2.7e-06 40041002576 HMMPfam hit to PF00132, Bacterial transferase hexapeptide repeat, score 4.3 40041002577 HMMPfam hit to PF00132, Bacterial transferase hexapeptide repeat, score 9.7 40041002578 HMMPfam hit to PF00132, Bacterial transferase hexapeptide repeat, score 1 40041002579 HMMPfam hit to PF00132, Bacterial transferase hexapeptide repeat, score 43 40041002580 HMMPfam hit to PF00132, Bacterial transferase hexapeptide repeat, score 36 40041002581 HMMPfam hit to PF00132, Bacterial transferase hexapeptide repeat, score 4.4 40041002582 HMMPfam hit to PF00132, Bacterial transferase hexapeptide repeat, score 14 40041002583 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 40041002584 dimer interface [polypeptide binding]; other site 40041002585 ADP-ribose binding site [chemical binding]; other site 40041002586 active site 40041002587 nudix motif; other site 40041002588 metal binding site [ion binding]; metal-binding site 40041002589 HMMPfam hit to PF00293, NUDIX hydrolase, core, score 2.2e-22 40041002590 PS00038 Myc-type, 'helix-loop-helix' dimerization domain signature. 40041002591 1 probable transmembrane helix predicted for SZO04790 by TMHMM2.0 at aa 61-80 40041002592 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Validated; Region: PRK05584 40041002593 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Region: MTA/SAH-Nsdase; TIGR01704 40041002594 HMMPfam hit to PF01048, Nucleoside phosphorylase, score 8.7e-67 40041002595 Mn-dependent transcriptional regulator [Transcription]; Region: TroR; COG1321 40041002596 Iron dependent repressor, N-terminal DNA binding domain; Region: Fe_dep_repress; pfam01325 40041002597 Iron dependent repressor, metal binding and dimerisation domain; Region: Fe_dep_repr_C; pfam02742 40041002598 FeoA domain; Region: FeoA; pfam04023 40041002599 HMMPfam hit to PF04023, Ferrous iron transporter, FeoA subunit, score 2e-13 40041002600 HMMPfam hit to PF02742, Iron dependent repressor, score 8.1e-23 40041002601 HMMPfam hit to PF01325, Iron dependent repressor, score 5.3e-14 40041002602 Predicted helix-turn-helix motif with score 1322.000, SD 3.69 at aa 22-43, sequence ISNKMVAERMKVSAPAVSEMIK 40041002603 ABC-type metal ion transport system, periplasmic component/surface adhesin [Inorganic ion transport and metabolism]; Region: LraI; COG0803 40041002604 Metal binding protein PsaA. These proteins have been shown to function as initial receptors in ABC transport of Mn2+ and as surface adhesins in some eubacterial species. They belong to the TroA superfamily of periplasmic metal binding proteins that...; Region: PsaA; cd01137 40041002605 metal binding site [ion binding]; metal-binding site 40041002606 1 probable transmembrane helix predicted for SZO04820 by TMHMM2.0 at aa 7-26 40041002607 HMMPfam hit to PF01297, Periplasmic solute binding protein, score 1.1e-142 40041002608 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 40041002609 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 40041002610 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 40041002611 HMMPfam hit to PF00005, ABC transporter related, score 1.6e-51 40041002612 PS00017 ATP/GTP-binding site motif A (P-loop). 40041002613 PS00211 ABC transporters family signature. 40041002614 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 40041002615 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 40041002616 ABC-ATPase subunit interface; other site 40041002617 dimer interface [polypeptide binding]; other site 40041002618 putative PBP binding regions; other site 40041002619 HMMPfam hit to PF00950, ABC-3, score 3.8e-129 40041002620 7 probable transmembrane helices predicted for SZO04840 by TMHMM2.0 at aa 15-37, 58-80, 95-117, 137-159, 179-201, 214-236 and 246-268 40041002621 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 40041002622 Peptidyl-prolyl cis-trans isomerase (rotamase) - cyclophilin family [Posttranslational modification, protein turnover, chaperones]; Region: PpiB; COG0652 40041002623 active site 40041002624 HMMPfam hit to PF00160, Peptidyl-prolyl cis-trans isomerase, cyclophilin-type, score 3.2e-42 40041002625 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 40041002626 DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674 40041002627 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 40041002628 Ftsk gamma domain; Region: Ftsk_gamma; pfam09397 40041002629 5 probable transmembrane helices predicted for SZO04860 by TMHMM2.0 at aa 49-68, 78-100, 107-129, 144-166 and 173-195 40041002630 HMMPfam hit to PF01580, Cell divisionFtsK/SpoIIIE, score 5.5e-76 40041002631 PS00017 ATP/GTP-binding site motif A (P-loop). 40041002632 Protein of unknown function (DUF3397); Region: DUF3397; pfam11877 40041002633 3 probable transmembrane helices predicted for SZO04870 by TMHMM2.0 at aa 7-29, 58-80 and 93-115 40041002634 Transcriptional regulators [Transcription]; Region: PurR; COG1609 40041002635 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 40041002636 DNA binding site [nucleotide binding] 40041002637 domain linker motif; other site 40041002638 HMMPfam hit to PF00356, Bacterial regulatory protein, LacI, score 7.1e-14 40041002639 Predicted helix-turn-helix motif with score 2253.000, SD 6.86 at aa 5-26, sequence VTIKDVAREAGVSVATVSYVIN 40041002640 PS00356 Bacterial regulatory proteins, lacI family signature. 40041002641 50S ribosomal protein L11; Validated; Region: rplK; PRK00140 40041002642 Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349 40041002643 23S rRNA interface [nucleotide binding]; other site 40041002644 L7/L12 interface [polypeptide binding]; other site 40041002645 putative thiostrepton binding site; other site 40041002646 L25 interface [polypeptide binding]; other site 40041002647 HMMPfam hit to PF03946, Ribosomal protein L11, score 5.2e-35 40041002648 HMMPfam hit to PF00298, Ribosomal protein L11, score 4.2e-41 40041002649 PS00359 Ribosomal protein L11 signature. 40041002650 Ribosomal protein L1. The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA. In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403 40041002651 mRNA/rRNA interface [nucleotide binding]; other site 40041002652 HMMPfam hit to PF00687, Ribosomal protein L1, score 4.8e-117 40041002653 Fibronectin-binding protein signal sequence; Region: Fb_signal; pfam08341 40041002654 TQXA domain; Region: TQXA_dom; TIGR03934 40041002655 Collagen triple helix repeat (20 copies); Region: Collagen; pfam01391 40041002656 HMMPfam hit to PF00746, Surface protein from Gram-positive cocci, anchor region, score 3e-05 40041002657 1 probable transmembrane helix predicted for SZO04910 by TMHMM2.0 at aa 725-744 40041002658 HMMPfam hit to PF01391, Collagen triple helix repeat, score 4.9e-15 40041002659 HMMPfam hit to PF01391, Collagen triple helix repeat, score 3.9e-14 40041002660 HMMPfam hit to PF01391, Collagen triple helix repeat, score 4.2e-13 40041002661 HMMPfam hit to PF01391, Collagen triple helix repeat, score 2e-14 40041002662 HMMPfam hit to PF01391, Collagen triple helix repeat, score 8.6e-13 40041002663 HMMPfam hit to PF08341, Fibronectin-binding, signal sequence, score 5.8e-06 40041002664 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 40041002665 The substrate-binding component of an ABC-type nickel import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA; cd08489 40041002666 substrate binding site [chemical binding]; other site 40041002667 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 40041002668 HMMPfam hit to PF00496, Bacterial extracellular solute-binding protein, family 5, score 1.2e-81 40041002669 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 40041002670 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 40041002671 dimer interface [polypeptide binding]; other site 40041002672 conserved gate region; other site 40041002673 putative PBP binding loops; other site 40041002674 ABC-ATPase subunit interface; other site 40041002675 6 probable transmembrane helices predicted for SZO04930 by TMHMM2.0 at aa 5-23, 95-117, 130-152, 167-184, 226-248 and 268-290 40041002676 HMMPfam hit to PF00528, Binding-protein-dependent transport systems inner membrane component, score 1.3e-41 40041002677 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 40041002678 nickel ABC transporter, permease subunit NikC; Region: nickel_nikC; TIGR02790 40041002679 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 40041002680 dimer interface [polypeptide binding]; other site 40041002681 conserved gate region; other site 40041002682 putative PBP binding loops; other site 40041002683 ABC-ATPase subunit interface; other site 40041002684 6 probable transmembrane helices predicted for SZO04940 by TMHMM2.0 at aa 5-27, 70-92, 99-118, 122-144, 189-211 and 231-253 40041002685 HMMPfam hit to PF00528, Binding-protein-dependent transport systems inner membrane component, score 9.6e-30 40041002686 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 40041002687 nickel import ATP-binding protein NikD; Region: nickel_nikD; TIGR02770 40041002688 Walker A/P-loop; other site 40041002689 ATP binding site [chemical binding]; other site 40041002690 Q-loop/lid; other site 40041002691 ABC transporter signature motif; other site 40041002692 Walker B; other site 40041002693 D-loop; other site 40041002694 H-loop/switch region; other site 40041002695 HMMPfam hit to PF00005, ABC transporter related, score 9e-38 40041002696 PS00017 ATP/GTP-binding site motif A (P-loop). 40041002697 PS00211 ABC transporters family signature. 40041002698 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 40041002699 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 40041002700 Walker A/P-loop; other site 40041002701 ATP binding site [chemical binding]; other site 40041002702 Q-loop/lid; other site 40041002703 ABC transporter signature motif; other site 40041002704 Walker B; other site 40041002705 D-loop; other site 40041002706 H-loop/switch region; other site 40041002707 HMMPfam hit to PF00005, ABC transporter related, score 1.7e-56 40041002708 PS00017 ATP/GTP-binding site motif A (P-loop). 40041002709 PS00211 ABC transporters family signature. 40041002710 UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254 40041002711 putative nucleotide binding site [chemical binding]; other site 40041002712 uridine monophosphate binding site [chemical binding]; other site 40041002713 homohexameric interface [polypeptide binding]; other site 40041002714 HMMPfam hit to PF00696, Aspartate/glutamate/uridylate kinase, score 3.6e-59 40041002715 ribosome recycling factor; Reviewed; Region: frr; PRK00083 40041002716 Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation. Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520 40041002717 hinge region; other site 40041002718 HMMPfam hit to PF01765, Ribosome recycling factor, score 9.7e-94 40041002719 Predicted RNA-bindining protein (contains S1 and HTH domains) [General function prediction only]; Region: COG2996 40041002720 S1 domain; Region: S1_2; pfam13509 40041002721 Ribosomal protein S1-like RNA-binding domain; Region: S1; smart00316 40041002722 methionine sulfoxide reductase A; Provisional; Region: PRK14054 40041002723 HMMPfam hit to PF01625, Methionine sulphoxide reductase A, score 4.7e-81 40041002724 hypothetical protein; Provisional; Region: PRK13672 40041002725 HMMPfam hit to PF06855, Protein of unknown function DUF1250, score 9.1e-28 40041002726 Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702 40041002727 PhoH-like protein; Region: PhoH; pfam02562 40041002728 HMMPfam hit to PF02562, PhoH-like protein, score 1.9e-135 40041002729 PS00017 ATP/GTP-binding site motif A (P-loop). 40041002730 Uncharacterized subfamily of Uracil-DNA glycosylases; Region: UDG_like_1; cd10033 40041002731 putative uracil binding site [chemical binding]; other site 40041002732 putative active site [active] 40041002733 HMMPfam hit to PF03167, Uracil-DNA glycosylase superfamily, score 4.3e-07 40041002734 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 40041002735 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 40041002736 Coenzyme A binding pocket [chemical binding]; other site 40041002737 HMMPfam hit to PF00583, GCN5-related N-acetyltransferase, score 9.8e-08 40041002738 metal-binding heat shock protein; Provisional; Region: PRK00016 40041002739 HMMPfam hit to PF02130, Protein of unknown function UPF0054, score 4.5e-26 40041002740 Diacylglycerol kinase [Cell envelope biogenesis, outer membrane]; Region: DgkA; COG0818 40041002741 HMMPfam hit to PF01219, Prokaryotic diacylglycerol kinase, score 3.2e-48 40041002742 2 probable transmembrane helices predicted for SZO05060 by TMHMM2.0 at aa 41-63 and 103-125 40041002743 PS01069 Prokaryotic diacylglycerol kinase signature. 40041002744 GTPase Era; Reviewed; Region: era; PRK00089 40041002745 E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163 40041002746 G1 box; other site 40041002747 GTP/Mg2+ binding site [chemical binding]; other site 40041002748 Switch I region; other site 40041002749 G2 box; other site 40041002750 Switch II region; other site 40041002751 G3 box; other site 40041002752 G4 box; other site 40041002753 G5 box; other site 40041002754 KH domain; Region: KH_2; pfam07650 40041002755 HMMPfam hit to PF01926, GTP-binding protein, HSR1-related, score 8.3e-40 40041002756 PS00017 ATP/GTP-binding site motif A (P-loop). 40041002757 HMMPfam hit to PF07650, K Homology, type 2, score 7e-29 40041002759 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 40041002761 HMMPfam hit to PF02687, Protein of unknown function DUF214, permase predicted, score 1.2e-06 40041002762 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 40041002763 ATP-binding cassette domain of multidrug resistance protein-like transporters; Region: ABCC_MRP_Like; cd03228 40041002764 Walker A/P-loop; other site 40041002765 ATP binding site [chemical binding]; other site 40041002766 Q-loop/lid; other site 40041002767 ABC transporter signature motif; other site 40041002768 Walker B; other site 40041002769 D-loop; other site 40041002770 H-loop/switch region; other site 40041002771 5 probable transmembrane helices predicted for SZO05100 by TMHMM2.0 at aa 13-35, 55-77, 125-147, 151-170 and 237-259 40041002772 HMMPfam hit to PF00005, ABC transporter related, score 9.7e-39 40041002773 PS00017 ATP/GTP-binding site motif A (P-loop). 40041002774 PS00211 ABC transporters family signature. 40041002775 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120 40041002776 active site 40041002777 ATP binding site [chemical binding]; other site 40041002778 LanC-like proteins. LanC is the cyclase enzyme of the lanthionine synthetase. Lanthionine is a lantibiotic, a unique class of peptide antibiotics. They are ribosomally synthesized as a precursor peptide and then post-translationally modified to contain...; Region: LanC_like; cl04955 40041002779 Lanthionine synthetase C-like protein; Region: LANC_like; pfam05147 40041002780 active site 40041002781 zinc binding site [ion binding]; other site 40041002782 HMMPfam hit to PF05147, Lanthionine synthetase C-like, score 7.3e-05 40041002783 Protease II [Amino acid transport and metabolism]; Region: PtrB; COG1770 40041002784 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 40041002785 HMMPfam hit to PF00326, Peptidase S9, prolyl oligopeptidase active site region, score 7.7e-23 40041002786 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 40041002787 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 40041002788 Walker A/P-loop; other site 40041002789 ATP binding site [chemical binding]; other site 40041002790 Q-loop/lid; other site 40041002791 ABC transporter signature motif; other site 40041002792 Walker B; other site 40041002793 D-loop; other site 40041002794 H-loop/switch region; other site 40041002795 HMMPfam hit to PF00005, ABC transporter related, score 1.2e-56 40041002796 PS00017 ATP/GTP-binding site motif A (P-loop). 40041002797 PS00211 ABC transporters family signature. 40041002799 Ortholog of S. equi 4047 (FM204883) SEQ1632 40041002800 LytTr DNA-binding domain; Region: LytTR; cl04498 40041002801 HMMPfam hit to PF04397, LytTr DNA-binding region, score 6e-08 40041002802 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 40041002803 ABC-type multidrug transport system, ATPase component; Region: ABC_drug_resistance_like; cd03264 40041002804 Walker A/P-loop; other site 40041002805 ATP binding site [chemical binding]; other site 40041002806 Q-loop/lid; other site 40041002807 ABC transporter signature motif; other site 40041002808 Walker B; other site 40041002809 D-loop; other site 40041002810 H-loop/switch region; other site 40041002811 HMMPfam hit to PF00005, ABC transporter related, score 5.5e-54 40041002812 PS00017 ATP/GTP-binding site motif A (P-loop). 40041002813 PS00211 ABC transporters family signature. 40041002814 6 probable transmembrane helices predicted for SZO05170 by TMHMM2.0 at aa 17-39, 154-176, 204-226, 265-287, 294-316 and 349-371 40041002815 PS00225 Crystallins beta and gamma 'Greek key' motif signature. 40041002816 DNA-binding transcriptional regulator HcaR; Provisional; Region: PRK09906 40041002817 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 40041002818 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 40041002819 dimerization interface [polypeptide binding]; other site 40041002820 HMMPfam hit to PF03466, LysR, substrate-binding, score 7.4e-12 40041002821 HMMPfam hit to PF00126, Bacterial regulatory protein, LysR, score 1.7e-09 40041002822 Predicted helix-turn-helix motif with score 1789.000, SD 5.28 at aa 17-38, sequence FNLSRTAQQLYISQPTLSIMIN 40041002823 putative acyltransferase; Provisional; Region: PRK05790 40041002824 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 40041002825 dimer interface [polypeptide binding]; other site 40041002826 active site 40041002827 HMMPfam hit to PF00108, Thiolase, score 1.6e-156 40041002828 HMMPfam hit to PF02803, Thiolase, score 1.4e-79 40041002829 PS00737 Thiolases signature 2. 40041002830 PS00099 Thiolases active site. 40041002831 Acyl CoA:acetate/3-ketoacid CoA transferase, alpha subunit [Lipid metabolism]; Region: AtoD; COG1788 40041002832 HMMPfam hit to PF01144, Coenzyme A transferase, score 5.9e-77 40041002833 PS01273 CoA transferases signature 1. 40041002834 3-oxoacid CoA-transferase, B subunit; Region: pcaJ_scoB_fam; TIGR02428 40041002835 HMMPfam hit to PF01144, Coenzyme A transferase, score 4.1e-48 40041002836 PS01274 CoA transferases signature 2. 40041002837 3-hydroxybutyrate dehydrogenase; Provisional; Region: PRK12429 40041002838 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 40041002839 NAD(P) binding site [chemical binding]; other site 40041002840 active site 40041002841 HMMPfam hit to PF00106, Short-chain dehydrogenase/reductase SDR, score 1.4e-23 40041002842 PS00061 Short-chain dehydrogenases/reductases family signature. 40041002843 H+/gluconate symporter and related permeases [Carbohydrate transport and metabolism / Amino acid transport and metabolism]; Region: GntT; COG2610 40041002844 fructuronate transporter; Provisional; Region: PRK10034; cl15264 40041002845 12 probable transmembrane helices predicted for SZO05230 by TMHMM2.0 at aa 4-21, 28-50, 65-87, 108-130, 150-172, 185-207, 239-261, 268-285, 307-329, 342-364, 387-409 and 422-441 40041002846 HMMPfam hit to PF03600, Divalent ion symporter, score 2.2e-38 40041002847 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 40041002848 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_18; cd04677 40041002849 nudix motif; other site 40041002850 HMMPfam hit to PF00293, NUDIX hydrolase, core, score 1.8e-21 40041002851 PS00893 mutT domain signature. 40041002852 MarR family; Region: MarR_2; cl17246 40041002853 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 40041002854 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 40041002855 HMMPfam hit to PF00480, ROK, score 4.1e-10 40041002856 Predicted helix-turn-helix motif with score 1378.000, SD 3.88 at aa 23-44, sequence ISRIDISKLTHITPATVGAITK 40041002857 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 40041002858 PTS_IIB_chitobiose_lichenan: subunit IIB of enzyme II (EII) of the N,N-diacetylchitobiose-specific and lichenan-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In these systems, EII is either a lichenan- or an N; Region: PTS_IIB_chitobiose_lichenan; cd05564 40041002859 active site 40041002860 P-loop; other site 40041002861 phosphorylation site [posttranslational modification] 40041002862 HMMPfam hit to PF02302, Phosphotransferase system, lactose/cellobiose-specific IIB subunit, score 4.3e-33 40041002863 PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_lac; cd00215 40041002864 active site 40041002865 methionine cluster; other site 40041002866 phosphorylation site [posttranslational modification] 40041002867 metal binding site [ion binding]; metal-binding site 40041002868 HMMPfam hit to PF02255, Phosphotransferase system, lactose/cellobiose-specific IIA subunit, score 1.3e-38 40041002869 Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455 40041002870 cellobiose phosphotransferase system IIC component; Reviewed; Region: celD; PRK09592 40041002871 HMMPfam hit to PF02378, Phosphotransferase system, EIIC, score 2.3e-73 40041002872 10 probable transmembrane helices predicted for SZO05290 by TMHMM2.0 at aa 34-56, 76-93, 100-122, 137-159, 180-202, 217-239, 241-263, 293-312, 350-372 and 402-424 40041002873 Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455 40041002874 cellobiose phosphotransferase system IIC component; Reviewed; Region: celD; PRK09592 40041002875 HMMPfam hit to PF02378, Phosphotransferase system, EIIC, score 2.7e-63 40041002876 10 probable transmembrane helices predicted for SZO05300 by TMHMM2.0 at aa 31-53, 73-95, 107-129, 173-192, 212-231, 246-268, 273-295, 310-332, 370-392 and 422-441 40041002877 YSIRK type signal peptide; Region: YSIRK_signal; cl04650 40041002878 choice-of-anchor C domain; Region: choice_anch_C; TIGR04362 40041002879 Laminarinase, member of the glycosyl hydrolase family 16; Region: GH16_laminarinase_like; cd08023 40041002880 active site 40041002881 catalytic residues [active] 40041002882 Pentraxins are plasma proteins characterized by their pentameric discoid assembly and their Ca2+ dependent ligand binding, such as Serum amyloid P component (SAP) and C-reactive Protein (CRP), which are cytokine-inducible acute-phase proteins implicated...; Region: PTX; cl00102 40041002883 Sialidases or neuraminidases function to bind and hydrolyze terminal sialic acid residues from various glycoconjugates as well as playing roles in pathogenesis, bacterial nutrition and cellular interactions. They have a six-bladed, beta-propeller fold...; Region: Sialidase; cd00260 40041002884 catalytic site [active] 40041002885 Asp-box motif; other site 40041002886 Sialidases or neuraminidases function to bind and hydrolyze terminal sialic acid residues from various glycoconjugates as well as playing roles in pathogenesis, bacterial nutrition and cellular interactions. They have a six-bladed, beta-propeller fold...; Region: Sialidase; cd00260 40041002887 Asp-box motif; other site 40041002888 catalytic site [active] 40041002889 HMMPfam hit to PF04650, YSIRK Gram-positive signal peptide, score 2.9e-06 40041002890 1 probable transmembrane helix predicted for SZO05310 by TMHMM2.0 at aa 20-42 40041002891 PS00099 Thiolases active site. 40041002892 HMMPfam hit to PF02018, Carbohydrate-binding, CenC-like, score 0.00029 40041002893 HMMPfam hit to PF00722, Glycoside hydrolase, family 16, score 5.9e-20 40041002894 HMMPfam hit to PF02012, Glycoside hydrolase, BNR repeat, score 0.087 40041002895 HMMPfam hit to PF02012, Glycoside hydrolase, BNR repeat, score 0.51 40041002896 HMMPfam hit to PF02012, Glycoside hydrolase, BNR repeat, score 0.037 40041002897 HMMPfam hit to PF02012, Glycoside hydrolase, BNR repeat, score 0.22 40041002898 Glycosyl hydrolases family 35; Region: Glyco_hydro_35; pfam01301 40041002899 HMMPfam hit to PF01301, Glycoside hydrolase, family 35, score 4.8e-176 40041002900 formamidopyrimidine/5-formyluracil/ 5-hydroxymethyluracil DNA glycosylase; Validated; Region: PRK01103 40041002901 N-terminal domain of Escherichia coli Fpg1/MutM and related bacterial DNA glycosylases; Region: EcFpg-like_N; cd08966 40041002902 DNA binding site [nucleotide binding] 40041002903 catalytic residue [active] 40041002904 H2TH interface [polypeptide binding]; other site 40041002905 putative catalytic residues [active] 40041002906 turnover-facilitating residue; other site 40041002907 intercalation triad [nucleotide binding]; other site 40041002908 8OG recognition residue [nucleotide binding]; other site 40041002909 putative reading head residues; other site 40041002910 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 40041002911 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 40041002912 HMMPfam hit to PF01149, Formamidopyrimidine-DNA glycosylase, catalytic, score 2.4e-48 40041002913 HMMPfam hit to PF06831, Formamidopyrimidine-DNA glycolase, H2TH DNA binding, score 3e-43 40041002914 HMMPfam hit to PF06827, Formamidopyrimidine-DNA glycolase, C-terminal, score 3.3e-07 40041002915 Dephospho-CoA kinase [Coenzyme metabolism]; Region: CoaE; COG0237 40041002916 Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022 40041002917 CoA-binding site [chemical binding]; other site 40041002918 ATP-binding [chemical binding]; other site 40041002919 HMMPfam hit to PF01121, Dephospho-CoA kinase, score 7.1e-50 40041002920 PS00017 ATP/GTP-binding site motif A (P-loop). 40041002921 Fibronectin-binding protein signal sequence; Region: Fb_signal; pfam08341 40041002922 TQXA domain; Region: TQXA_dom; TIGR03934 40041002923 HMMPfam hit to PF00746, Surface protein from Gram-positive cocci, anchor region, score 3.3e-05 40041002924 2 probable transmembrane helices predicted for SZO05350 by TMHMM2.0 at aa 9-31 and 503-522 40041002925 HMMPfam hit to PF08341, Fibronectin-binding, signal sequence, score 2.2e-07 40041002926 putative transposase OrfB; Reviewed; Region: PHA02517 40041002927 HTH-like domain; Region: HTH_21; pfam13276 40041002928 Integrase core domain; Region: rve; pfam00665 40041002929 Integrase core domain; Region: rve_2; pfam13333 40041002930 HMMPfam hit to PF00665, Integrase, catalytic core, score 1.6e-41 40041002931 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 40041002932 Helix-turn-helix domain; Region: HTH_28; pfam13518 40041002933 Helix-turn-helix domain; Region: HTH_28; pfam13518 40041002934 Winged helix-turn helix; Region: HTH_29; pfam13551 40041002935 HMMPfam hit to PF01527, Transposase IS3/IS911, score 6e-07 40041002936 Predicted helix-turn-helix motif with score 1421.000, SD 4.03 at aa 159-180, sequence KDYQAAIEKYGISYQQVYSWVR 40041002937 HMMPfam hit to PF01527, Transposase IS3/IS911, score 1.1e-06 40041002938 Fibronectin-binding protein signal sequence; Region: Fb_signal; pfam08341 40041002939 TQXA domain; Region: TQXA_dom; TIGR03934 40041002940 Collagen triple helix repeat (20 copies); Region: Collagen; pfam01391 40041002941 Collagen triple helix repeat (20 copies); Region: Collagen; pfam01391 40041002942 HMMPfam hit to PF00746, Surface protein from Gram-positive cocci, anchor region, score 0.00031 40041002943 1 probable transmembrane helix predicted for SZO05380 by TMHMM2.0 at aa 651-670 40041002944 HMMPfam hit to PF01391, Collagen triple helix repeat, score 2.5e-14 40041002945 HMMPfam hit to PF01391, Collagen triple helix repeat, score 3e-11 40041002946 HMMPfam hit to PF01391, Collagen triple helix repeat, score 1.1e-13 40041002947 HMMPfam hit to PF01391, Collagen triple helix repeat, score 1.7e-09 40041002948 HMMPfam hit to PF01391, Collagen triple helix repeat, score 5e-13 40041002949 HMMPfam hit to PF08341, Fibronectin-binding, signal sequence, score 1.4e-08 40041002950 50S ribosomal protein L33; Validated; Region: rpmG; PRK00595 40041002951 HMMPfam hit to PF00471, Ribosomal protein L33, score 4.3e-12 40041002952 preprotein translocase subunit SecG; Reviewed; Region: secG; PRK06870 40041002953 HMMPfam hit to PF03840, Preprotein translocase SecG subunit, score 2e-30 40041002954 2 probable transmembrane helices predicted for SZO05400 by TMHMM2.0 at aa 5-22 and 53-75 40041002955 ribonuclease R; Region: RNase_R; TIGR02063 40041002956 Ribonuclease B OB domain; Region: OB_RNB; pfam08206 40041002957 RNB domain; Region: RNB; pfam00773 40041002958 S1_RNase_R: RNase R C-terminal S1 domain. RNase R is a processive 3' to 5' exoribonuclease, which is a homolog of RNase II. RNase R degrades RNA with secondary structure having a 3' overhang of at least 7 nucleotides. RNase R and PNPase...; Region: S1_RNase_R; cd04471 40041002959 RNA binding site [nucleotide binding]; other site 40041002960 HMMPfam hit to PF08206, Ribonuclease B, OB region N-terminal, score 6.7e-20 40041002961 HMMPfam hit to PF00773, Ribonuclease II and R, score 2.1e-153 40041002962 PS01175 Ribonuclease II family signature. 40041002963 HMMPfam hit to PF00575, S1, RNA binding, score 1.8e-12 40041002964 Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294 40041002965 SmpB-tmRNA interface; other site 40041002966 HMMPfam hit to PF01668, SmpB protein, score 2.1e-36 40041002967 PS01317 Protein smpB signature. 40041002968 undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714 40041002969 Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187 40041002970 Ligand binding site; other site 40041002971 Putative Catalytic site; other site 40041002972 DXD motif; other site 40041002973 2 probable transmembrane helices predicted for SZO05430 by TMHMM2.0 at aa 230-252 and 264-286 40041002974 HMMPfam hit to PF00535, Glycosyl transferase, family 2, score 2e-33 40041002975 NAD(P)H:FMN oxidoreductase family. This domain catalyzes the reduction of flavin, nitrocompound, quinones and azo compounds using NADH or NADPH as an electron donor. The enzyme is a homodimer, and each monomer binds a FMN as co-factor. This family...; Region: NfsB_like_nitroreductase; cd02149 40041002976 dimer interface [polypeptide binding]; other site 40041002977 FMN binding site [chemical binding]; other site 40041002978 HMMPfam hit to PF00881, Nitroreductase, score 3.3e-47 40041002979 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 40041002980 non-specific DNA binding site [nucleotide binding]; other site 40041002981 salt bridge; other site 40041002982 sequence-specific DNA binding site [nucleotide binding]; other site 40041002983 transcriptional activator, Rgg/GadR/MutR family, C-terminal domain; Region: RGG_Cterm; TIGR01716 40041002984 HMMPfam hit to PF01381, Helix-turn-helix type 3, score 6.3e-09 40041002985 Ortholog of S. equi 4047 (FM204883) SEQ1598; CDS contains a frameshift around codon 71 40041002986 5 probable transmembrane helices predicted for SZO05460 by TMHMM2.0 at aa 13-35, 50-72, 120-142, 147-169 and 230-252 40041002987 HMMPfam hit to PF00005, ABC transporter related, score 6.8e-36 40041002988 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 40041002989 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 40041002990 Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092 40041002991 active site 40041002992 HMMPfam hit to PF00557, Peptidase M24, catalytic core, score 1.4e-74 40041002993 PS00491 Aminopeptidase P and proline dipeptidase signature. 40041002994 HMMPfam hit to PF01321, Creatinase, score 5.8e-15 40041002995 catabolite control protein A; Region: ccpA; TIGR01481 40041002996 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 40041002997 DNA binding site [nucleotide binding] 40041002998 domain linker motif; other site 40041002999 Ligand-binding domain of the catabolite control protein A (CcpA), which functions as the major transcriptional regulator of carbon catabolite repression/regulation; Region: PBP1_CcpA_like; cd06298 40041003000 dimerization interface [polypeptide binding]; other site 40041003001 effector binding site; other site 40041003002 HMMPfam hit to PF00356, Bacterial regulatory protein, LacI, score 4.4e-14 40041003003 Predicted helix-turn-helix motif with score 2166.000, SD 6.56 at aa 7-28, sequence ITIYDVAREAGVSMATVSRVVN 40041003004 PS00356 Bacterial regulatory proteins, lacI family signature. 40041003005 HMMPfam hit to PF00532, Periplasmic binding protein/LacI transcriptional regulator, score 6.5e-07 40041003006 cytoplasmic alpha-amylase; Reviewed; Region: PRK09441 40041003007 Alpha amylase catalytic domain found in bacterial and fungal Alpha amylases (also called 1,4-alpha-D-glucan-4-glucanohydrolase); Region: AmyAc_bac_fung_AmyA; cd11318 40041003008 active site 40041003009 Na/Ca binding site [ion binding]; other site 40041003010 catalytic site [active] 40041003011 Domain of unknown function (DUF1939); Region: DUF1939; pfam09154 40041003012 HMMPfam hit to PF00128, Glycosyl hydrolase, family 13, catalytic region, score 1.7e-73 40041003013 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 40041003014 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 40041003015 HMMPfam hit to PF00534, Glycosyl transferase, group 1, score 2.5e-11 40041003016 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 40041003017 This family is most closely related to the GT1 family of glycosyltransferases. UDP-glucose-diacylglycerol glucosyltransferase (UGDG; also known as 1,2-diacylglycerol 3-glucosyltransferase) catalyzes the transfer of glucose from UDP-glucose to 1; Region: GT1_UGDG_like; cd03817 40041003018 putative ADP-binding pocket [chemical binding]; other site 40041003019 HMMPfam hit to PF00534, Glycosyl transferase, group 1, score 3.5e-25 40041003020 threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK00413 40041003021 TGS _ThrRS_N: ThrRS (threonyl-tRNA Synthetase) is a class II tRNA synthetase that couples threonine to its cognate tRNA. In addition to its catalytic and anticodon-binding domains, ThrRS has an N-terminal TGS domain, named after the ThrRS, GTPase, and...; Region: TGS_ThrRS_N; cd01667 40041003022 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 40041003023 Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771 40041003024 active site 40041003025 dimer interface [polypeptide binding]; other site 40041003026 motif 1; other site 40041003027 motif 2; other site 40041003028 motif 3; other site 40041003029 ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860 40041003030 anticodon binding site; other site 40041003031 HMMPfam hit to PF02824, TGS, score 1.4e-14 40041003032 HMMPfam hit to PF07973, Threonyl/alanyl tRNA synthetase, SAD, score 2.3e-25 40041003033 HMMPfam hit to PF00587, Aminoacyl-tRNA synthetase, class II (G, H, P and S), score 1.3e-53 40041003034 HMMPfam hit to PF03129, Anticodon-binding, score 2.3e-29 40041003038 Ortholog of S. equi 4047 (FM204883) SEQ1588; CDS contains a nonsense mutation (ochre) after codon 296 40041003039 HMMPfam hit to PF00082, Peptidase S8 and S53, subtilisin, kexin, sedolisin, score 7.8e-32 40041003040 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 40041003041 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 40041003042 active site 40041003043 phosphorylation site [posttranslational modification] 40041003044 intermolecular recognition site; other site 40041003045 dimerization interface [polypeptide binding]; other site 40041003046 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 40041003047 DNA binding site [nucleotide binding] 40041003048 HMMPfam hit to PF00072, Response regulator receiver, score 2.8e-35 40041003049 HMMPfam hit to PF00486, Transcriptional regulatory protein, C-terminal, score 3.7e-19 40041003050 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 40041003051 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 40041003052 dimer interface [polypeptide binding]; other site 40041003053 phosphorylation site [posttranslational modification] 40041003054 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 40041003055 ATP binding site [chemical binding]; other site 40041003056 Mg2+ binding site [ion binding]; other site 40041003057 G-X-G motif; other site 40041003058 2 probable transmembrane helices predicted for SZO05570 by TMHMM2.0 at aa 15-37 and 142-164 40041003059 HMMPfam hit to PF00512, Histidine kinase A, N-terminal, score 2.3e-12 40041003060 HMMPfam hit to PF02518, ATP-binding region, ATPase-like, score 5e-17 40041003061 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 40041003062 gallidermin-class lantibiotic protection ABC transporter, ATP-binding subunit; Region: galliderm_ABC; TIGR03740 40041003063 Walker A/P-loop; other site 40041003064 ATP binding site [chemical binding]; other site 40041003065 Q-loop/lid; other site 40041003066 ABC transporter signature motif; other site 40041003067 Walker B; other site 40041003068 D-loop; other site 40041003069 H-loop/switch region; other site 40041003070 HMMPfam hit to PF00005, ABC transporter related, score 2e-51 40041003071 PS00017 ATP/GTP-binding site motif A (P-loop). 40041003072 PS00211 ABC transporters family signature. 40041003073 lantibiotic protection ABC transporter permease subunit, MutE/EpiE family; Region: lanti_perm_MutE; TIGR03732 40041003074 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 40041003075 6 probable transmembrane helices predicted for SZO05590 by TMHMM2.0 at aa 27-49, 53-71, 106-128, 138-157, 164-186 and 223-245 40041003076 6 probable transmembrane helices predicted for SZO05600 by TMHMM2.0 at aa 16-38, 48-67, 88-110, 125-147, 154-176 and 196-218 40041003077 ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: COG4586 40041003078 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 40041003079 Walker A/P-loop; other site 40041003080 ATP binding site [chemical binding]; other site 40041003081 Q-loop/lid; other site 40041003082 ABC transporter signature motif; other site 40041003083 Walker B; other site 40041003084 D-loop; other site 40041003085 H-loop/switch region; other site 40041003086 HMMPfam hit to PF00005, ABC transporter related, score 5.4e-44 40041003087 PS00017 ATP/GTP-binding site motif A (P-loop). 40041003088 PS00211 ABC transporters family signature. 40041003089 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4587 40041003090 ABC-2 family transporter protein; Region: ABC2_membrane_6; cl01496 40041003091 7 probable transmembrane helices predicted for SZO05620 by TMHMM2.0 at aa 26-48, 58-77, 114-136, 151-173, 186-205, 209-231 and 238-260 40041003092 HMMPfam hit to PF06182, Protein of unknown function DUF990, score 7.5e-17 40041003093 ABC-2 family transporter protein; Region: ABC2_membrane_6; cl01496 40041003094 5 probable transmembrane helices predicted for SZO05630 by TMHMM2.0 at aa 26-48, 115-137, 144-166, 200-222 and 227-249 40041003095 HMMPfam hit to PF06182, Protein of unknown function DUF990, score 4.3e-89 40041003096 DhaKLM operon coactivator DhaQ; Provisional; Region: PRK14483 40041003097 Dihydroxyacetone kinase [Carbohydrate transport and metabolism]; Region: DAK1; COG2376 40041003098 HMMPfam hit to PF02733, Dak kinase, score 8.5e-55 40041003099 probable dihydroxyacetone kinase regulator; Region: DHAK_reg; TIGR02366 40041003100 dihydroxyacetone kinase subunit DhaK; Provisional; Region: PRK14481 40041003101 Dihydroxyacetone kinase [Carbohydrate transport and metabolism]; Region: DAK1; COG2376 40041003102 HMMPfam hit to PF02733, Dak kinase, score 1.2e-107 40041003103 dihydroxyacetone kinase, phosphoprotein-dependent, L subunit; Region: dha_L_ycgS; TIGR02365 40041003104 HMMPfam hit to PF02734, Dak phosphatase, score 5.6e-77 40041003105 phosphotransferase mannnose-specific family component IIA; Provisional; Region: PRK14484 40041003106 HMMPfam hit to PF03610, Phosphotransferase system, fructose subfamily IIA component, score 3.1e-39 40041003107 Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cd00333 40041003108 amphipathic channel; other site 40041003109 Asn-Pro-Ala signature motifs; other site 40041003110 HMMPfam hit to PF00230, Major intrinsic protein, score 6e-34 40041003111 6 probable transmembrane helices predicted for SZO05690 by TMHMM2.0 at aa 4-26, 39-61, 81-103, 130-152, 162-184 and 211-233 40041003112 PS00221 MIP family signature. 40041003113 acetyl-CoA acetyltransferases; Region: AcCoA-C-Actrans; TIGR01930 40041003114 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 40041003115 dimer interface [polypeptide binding]; other site 40041003116 active site 40041003117 HMMPfam hit to PF00108, Thiolase, score 5.8e-17 40041003118 Predicted helix-turn-helix motif with score 1100.000, SD 2.93 at aa 148-169, sequence AGAERVAQAYQMTPSQLNQWTL 40041003119 HMMPfam hit to PF02803, Thiolase, score 2.9e-27 40041003120 1 probable transmembrane helix predicted for SZO05710 by TMHMM2.0 at aa 311-333 40041003121 acyl-CoA synthetase; Validated; Region: PRK07638 40041003122 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 40041003123 acyl-activating enzyme (AAE) consensus motif; other site 40041003124 AMP binding site [chemical binding]; other site 40041003125 active site 40041003126 CoA binding site [chemical binding]; other site 40041003127 HMMPfam hit to PF00501, AMP-dependent synthetase and ligase, score 3.7e-18 40041003128 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 40041003129 Protein of unknown function (DUF3114); Region: DUF3114; pfam11311 40041003130 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 40041003131 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 40041003132 active site 40041003133 phosphorylation site [posttranslational modification] 40041003134 intermolecular recognition site; other site 40041003135 dimerization interface [polypeptide binding]; other site 40041003136 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 40041003137 DNA binding site [nucleotide binding] 40041003138 HMMPfam hit to PF00072, Response regulator receiver, score 1.4e-45 40041003139 HMMPfam hit to PF00486, Transcriptional regulatory protein, C-terminal, score 3.2e-24 40041003140 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: VicK; COG5002 40041003141 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 40041003142 putative active site [active] 40041003143 heme pocket [chemical binding]; other site 40041003144 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 40041003145 dimer interface [polypeptide binding]; other site 40041003146 phosphorylation site [posttranslational modification] 40041003147 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 40041003148 ATP binding site [chemical binding]; other site 40041003149 Mg2+ binding site [ion binding]; other site 40041003150 G-X-G motif; other site 40041003151 1 probable transmembrane helix predicted for SZO05750 by TMHMM2.0 at aa 5-27 40041003152 HMMPfam hit to PF00989, PAS fold, score 6.6e-10 40041003153 HMMPfam hit to PF00512, Histidine kinase A, N-terminal, score 3.7e-20 40041003154 HMMPfam hit to PF02518, ATP-binding region, ATPase-like, score 2.9e-43 40041003155 Metal-dependent hydrolases of the beta-lactamase superfamily I [General function prediction only]; Region: PhnP; COG1235 40041003156 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 40041003157 HMMPfam hit to PF00753, Beta-lactamase-like, score 6e-20 40041003158 Restriction endonuclease FokI, recognition domain; Region: FokI_N; pfam02981 40041003159 Restriction endonuclease FokI, catalytic domain; Region: FokI_C; pfam02980 40041003160 Restriction endonuclease FokI, C terminal; Region: Endonuc-FokI_C; pfam09254 40041003161 HMMPfam hit to PF02981, Restriction endonuclease, type II, FokI, N-terminal, score 2.2e-17 40041003162 HMMPfam hit to PF02980, Restriction endonuclease, type II, FokI, catalytic region, score 8.7e-33 40041003163 HMMPfam hit to PF09254, Restriction endonuclease, type II, FokI, C terminal, score 3.7e-47 40041003164 D12 class N6 adenine-specific DNA methyltransferase; Region: MethyltransfD12; cl17344 40041003165 D12 class N6 adenine-specific DNA methyltransferase; Region: MethyltransfD12; cl17344 40041003166 HMMPfam hit to PF02086, D12 class N6 adenine-specific DNA methyltransferase, score 3.1e-19 40041003167 PS00092 N-6 Adenine-specific DNA methylases signature. 40041003168 HMMPfam hit to PF02086, D12 class N6 adenine-specific DNA methyltransferase, score 4.2e-56 40041003169 PS00018 EF-hand calcium-binding domain. 40041003170 M protein trans-acting positive regulator (MGA) HTH domain; Region: HTH_Mga; pfam08280 40041003171 Mga helix-turn-helix domain; Region: Mga; pfam05043 40041003172 M protein trans-acting positive regulator (MGA) PRD domain; Region: PRD_Mga; pfam08270 40041003173 HMMPfam hit to PF08280, Helix-turn-helix Mga, DNA-binding trans-acting positive regulator, score 7.4e-11 40041003174 HMMPfam hit to PF05043, M trans-acting positive regulator, score 1.2e-21 40041003175 HMMPfam hit to PF08270, Mga DNA-binding trans-acting positive regulator, PRD region, score 2.3e-45 40041003176 PS00038 Myc-type, 'helix-loop-helix' dimerization domain signature. 40041003177 ribonuclease III; Reviewed; Region: rnc; PRK00102 40041003178 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 40041003179 dimerization interface [polypeptide binding]; other site 40041003180 active site 40041003181 metal binding site [ion binding]; metal-binding site 40041003182 Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048 40041003183 dsRNA binding site [nucleotide binding]; other site 40041003184 HMMPfam hit to PF00636, Ribonuclease III, score 1.2e-44 40041003185 PS00517 Ribonuclease III family signature. 40041003186 HMMPfam hit to PF00035, Double-stranded RNA binding, score 8.7e-19 40041003187 Chromosome segregation ATPases [Cell division and chromosome partitioning]; Region: Smc; COG1196 40041003188 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 40041003189 Walker A/P-loop; other site 40041003190 ATP binding site [chemical binding]; other site 40041003191 Q-loop/lid; other site 40041003192 SMC proteins Flexible Hinge Domain; Region: SMC_hinge; smart00968 40041003193 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 40041003194 ABC transporter signature motif; other site 40041003195 Walker B; other site 40041003196 D-loop; other site 40041003197 H-loop/switch region; other site 40041003198 HMMPfam hit to PF02463, SMC protein, N-terminal, score 2.6e-110 40041003199 PS00017 ATP/GTP-binding site motif A (P-loop). 40041003200 HMMPfam hit to PF06470, SMCs flexible hinge, score 3.5e-28 40041003201 1 probable transmembrane helix predicted for SZO05820 by TMHMM2.0 at aa 11-30 40041003202 1 probable transmembrane helix predicted for SZO05830 by TMHMM2.0 at aa 35-52 40041003203 CDS contains a frameshift after codon 1. Frameshift occurs at a poly A hexamer. Similar to SZO01220, 87.9% identity (95.7% similar) in 140 aa overlap (1-140:1-140) 40041003204 1 probable transmembrane helix predicted for SZO05850 by TMHMM2.0 at aa 21-38 40041003205 bacteriocin-associated integral membrane (putative immunity) protein; Region: bact_immun_7tm; TIGR01654 40041003206 8 probable transmembrane helices predicted for SZO05890 by TMHMM2.0 at aa 7-25, 138-160, 189-211, 221-243, 263-282, 559-581, 602-624 and 628-650 40041003207 PS00017 ATP/GTP-binding site motif A (P-loop). 40041003208 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 40041003209 putative bacteriocin export ABC transporter, lactococcin 972 group; Region: L_ocin_972_ABC; TIGR03608 40041003210 Walker A/P-loop; other site 40041003211 ATP binding site [chemical binding]; other site 40041003212 Q-loop/lid; other site 40041003213 ABC transporter signature motif; other site 40041003214 Walker B; other site 40041003215 D-loop; other site 40041003216 H-loop/switch region; other site 40041003217 HMMPfam hit to PF00005, ABC transporter related, score 1.4e-49 40041003218 PS00017 ATP/GTP-binding site motif A (P-loop). 40041003219 PS00211 ABC transporters family signature. 40041003220 1 probable transmembrane helix predicted for SZO05910 by TMHMM2.0 at aa 5-22 40041003221 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 40041003222 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 40041003223 active site 40041003224 motif I; other site 40041003225 motif II; other site 40041003226 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 40041003227 HMMPfam hit to PF08282, HAD superfamily hydrolase-like, type 3, score 1.4e-77 40041003228 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 40041003229 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 40041003230 PS01228 Hypothetical cof family signature 1. 40041003231 HMMPfam hit to PF08282, HAD superfamily hydrolase-like, type 3, score 1.5e-85 40041003232 signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416 40041003233 SRP54-type protein, helical bundle domain; Region: SRP54_N; cl03758 40041003234 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 40041003235 P loop; other site 40041003236 GTP binding site [chemical binding]; other site 40041003237 HMMPfam hit to PF02881, Signal recognition particle, SRP54 subunit, helical bundle, score 2e-15 40041003238 HMMPfam hit to PF00448, Signal recognition particle, SRP54 subunit, GTPase, score 2.7e-112 40041003239 PS00017 ATP/GTP-binding site motif A (P-loop). 40041003240 PS00300 SRP54-type proteins GTP-binding domain signature. 40041003241 transcriptional antiterminator BglG; Provisional; Region: PRK09772 40041003242 CAT RNA binding domain; Region: CAT_RBD; pfam03123 40041003243 PRD domain; Region: PRD; pfam00874 40041003244 PRD domain; Region: PRD; pfam00874 40041003245 HMMPfam hit to PF03123, CAT RNA-binding region, score 2.4e-29 40041003246 HMMPfam hit to PF00874, PRD, score 8e-18 40041003247 PS00654 Transcriptional antiterminators bglG family signature. 40041003248 HMMPfam hit to PF00874, PRD, score 4.3e-14 40041003249 PTS system, beta-glucoside-specific IIABC component; Region: PTS-II-ABC-beta; TIGR01995 40041003250 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 40041003251 active site turn [active] 40041003252 phosphorylation site [posttranslational modification] 40041003253 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 40041003254 Phosphotransferase system IIA components [Carbohydrate transport and metabolism]; Region: NagE; COG2190 40041003255 HPr interaction site; other site 40041003256 glycerol kinase (GK) interaction site [polypeptide binding]; other site 40041003257 active site 40041003258 phosphorylation site [posttranslational modification] 40041003259 HMMPfam hit to PF00367, Phosphotransferase system, EIIB, score 1.9e-15 40041003260 PS01035 PTS EIIB domains cysteine phosphorylation site signature. 40041003261 HMMPfam hit to PF02378, Phosphotransferase system, EIIC, score 3.4e-33 40041003262 9 probable transmembrane helices predicted for SZO05960 by TMHMM2.0 at aa 111-133, 143-165, 172-194, 204-226, 246-268, 283-305, 352-374, 389-411 and 424-446 40041003263 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 40041003264 HMMPfam hit to PF00358, Phosphotransferase system, sugar-specific permease EIIA 1 domain, score 5.2e-65 40041003265 PS00371 PTS EIIA domains phosphorylation site signature 1. 40041003266 Beta-glucosidase/6-phospho-beta-glucosidase/beta- galactosidase [Carbohydrate transport and metabolism]; Region: BglB; COG2723 40041003267 beta-galactosidase; Region: BGL; TIGR03356 40041003268 HMMPfam hit to PF00232, Glycoside hydrolase, family 1, score 1.1e-153 40041003269 PS00653 Glycosyl hydrolases family 1 N-terminal signature. 40041003270 PS00572 Glycosyl hydrolases family 1 active site. 40041003271 Predicted membrane protein [Function unknown]; Region: COG3689 40041003272 HMMPfam hit to PF09323, Protein of unknown function DUF1980, score 5.3e-97 40041003273 3 probable transmembrane helices predicted for SZO05980 by TMHMM2.0 at aa 7-24, 39-61 and 82-104 40041003274 Predicted permeases [General function prediction only]; Region: COG0701 40041003275 7 probable transmembrane helices predicted for SZO05990 by TMHMM2.0 at aa 15-37, 58-80, 95-117, 122-144, 211-233, 240-262 and 277-299 40041003276 HMMPfam hit to PF03773, Protein of unknown function DUF318, transmembrane, score 9.6e-121 40041003277 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 40041003278 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 40041003279 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 40041003280 active site 40041003281 phosphorylation site [posttranslational modification] 40041003282 intermolecular recognition site; other site 40041003283 dimerization interface [polypeptide binding]; other site 40041003284 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 40041003285 DNA binding site [nucleotide binding] 40041003286 HMMPfam hit to PF00072, Response regulator receiver, score 7.4e-46 40041003287 HMMPfam hit to PF00486, Transcriptional regulatory protein, C-terminal, score 4.8e-26 40041003288 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 40041003289 dimer interface [polypeptide binding]; other site 40041003290 phosphorylation site [posttranslational modification] 40041003291 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 40041003292 ATP binding site [chemical binding]; other site 40041003293 Mg2+ binding site [ion binding]; other site 40041003294 G-X-G motif; other site 40041003295 2 probable transmembrane helices predicted for SZO06020 by TMHMM2.0 at aa 7-24 and 29-51 40041003296 HMMPfam hit to PF00512, Histidine kinase A, N-terminal, score 1.8e-19 40041003297 HMMPfam hit to PF02518, ATP-binding region, ATPase-like, score 4.5e-43 40041003298 PBP superfamily domain; Region: PBP_like_2; cl17296 40041003299 ABC-type phosphate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: PstS; COG0226 40041003300 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 40041003301 ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstC; COG0573 40041003302 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 40041003303 dimer interface [polypeptide binding]; other site 40041003304 conserved gate region; other site 40041003305 putative PBP binding loops; other site 40041003306 ABC-ATPase subunit interface; other site 40041003307 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 40041003308 6 probable transmembrane helices predicted for SZO06040 by TMHMM2.0 at aa 13-35, 74-96, 109-131, 141-163, 201-223 and 258-280 40041003309 HMMPfam hit to PF00528, Binding-protein-dependent transport systems inner membrane component, score 1.3e-10 40041003310 phosphate ABC transporter, permease protein PstA; Region: 3a0107s02c; TIGR00974 40041003311 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 40041003312 dimer interface [polypeptide binding]; other site 40041003313 conserved gate region; other site 40041003314 putative PBP binding loops; other site 40041003315 ABC-ATPase subunit interface; other site 40041003316 6 probable transmembrane helices predicted for SZO06050 by TMHMM2.0 at aa 7-29, 60-82, 95-117, 122-144, 176-198 and 241-263 40041003317 HMMPfam hit to PF00528, Binding-protein-dependent transport systems inner membrane component, score 3.5e-23 40041003318 PS00402 Binding-protein-dependent transport systems inner membrane comp. sign. 40041003319 phosphate transporter ATP-binding protein; Provisional; Region: PRK14240 40041003320 ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260 40041003321 Walker A/P-loop; other site 40041003322 ATP binding site [chemical binding]; other site 40041003323 Q-loop/lid; other site 40041003324 ABC transporter signature motif; other site 40041003325 Walker B; other site 40041003326 D-loop; other site 40041003327 H-loop/switch region; other site 40041003328 HMMPfam hit to PF00005, ABC transporter related, score 9.5e-59 40041003329 PS00017 ATP/GTP-binding site motif A (P-loop). 40041003330 PS00211 ABC transporters family signature. 40041003331 CDS contains a nonsense mutation (ochre) after codon 3 40041003332 HMMPfam hit to PF01895, PhoU, score 1.7e-13 40041003333 HMMPfam hit to PF01895, PhoU, score 2.8e-14 40041003334 Transcriptional accessory protein [Transcription]; Region: Tex; COG2183 40041003335 Tex-like protein N-terminal domain; Region: Tex_N; pfam09371 40041003336 Likely ribonuclease with RNase H fold; Region: YqgFc; smart00732 40041003337 S1_Tex: The C-terminal S1 domain of a transcription accessory factor called Tex, which has been characterized in Bordetella pertussis and Pseudomonas aeruginosa. The tex gene is essential in Bortella pertusis and is named for its role in toxin expression; Region: S1_Tex; cd05685 40041003338 RNA binding site [nucleotide binding]; other site 40041003339 Predicted helix-turn-helix motif with score 1676.000, SD 4.90 at aa 4-25, sequence MNHQNISEALGVTPKQISQVLA 40041003340 Predicted helix-turn-helix motif with score 1287.000, SD 3.57 at aa 583-604, sequence VNLEEMAEQLMLGQETLKDIIA 40041003341 HMMPfam hit to PF00575, S1, RNA binding, score 2.2e-19 40041003342 hypothetical protein; Provisional; Region: PRK04351 40041003343 Zn-dependent metalloprotease, SprT family [General function prediction only]; Region: SprT; COG3091 40041003344 HMMPfam hit to PF03926, Protein of unknown function DUF335, SprT, score 3.8e-65 40041003345 Putative stress-responsive transcriptional regulator [Transcription / Signal transduction mechanisms]; Region: PspC; COG1983 40041003346 HMMPfam hit to PF04024, PspC, score 8.2e-22 40041003347 1 probable transmembrane helix predicted for SZO06110 by TMHMM2.0 at aa 34-56 40041003348 HPr Serine kinase N terminus; Region: Hpr_kinase_N; pfam02603 40041003349 HPr kinase/phosphorylase; Provisional; Region: PRK05428 40041003350 HprK/P, the bifunctional histidine-containing protein kinase/phosphatase, controls the phosphorylation state of the phosphocarrier protein HPr and regulates the utilization of carbon sources by gram-positive bacteria. It catalyzes both the ATP-dependent...; Region: HprK_C; cd01918 40041003351 Hpr binding site; other site 40041003352 active site 40041003353 homohexamer subunit interaction site [polypeptide binding]; other site 40041003354 HMMPfam hit to PF02603, HPr Serine kinase, N-terminal, score 3.8e-28 40041003355 HMMPfam hit to PF07475, HPr Serine kinase, C-terminal, score 2.7e-70 40041003356 PS00017 ATP/GTP-binding site motif A (P-loop). 40041003357 prolipoprotein diacylglyceryl transferase; Reviewed; Region: PRK12437 40041003358 HMMPfam hit to PF01790, Prolipoprotein diacylglyceryl transferase, score 3.2e-133 40041003359 5 probable transmembrane helices predicted for SZO06140 by TMHMM2.0 at aa 15-33, 46-68, 83-105, 165-187 and 224-246 40041003360 PS01311 Prolipoprotein diacylglyceryl transferase signature. 40041003361 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 40041003362 Uncharacterized protein containing a divergent version of the methyl-accepting chemotaxis-like domain [General function prediction only]; Region: COG4768 40041003363 1 probable transmembrane helix predicted for SZO06150 by TMHMM2.0 at aa 4-26 40041003364 HMMPfam hit to PF06103, Protein of unknown function DUF948, bacterial, score 1.6e-45 40041003365 YtxH-like protein; Region: YtxH; pfam12732 40041003366 Protein of unknown function (DUF3270); Region: DUF3270; pfam11674 40041003367 2 probable transmembrane helices predicted for SZO06170 by TMHMM2.0 at aa 60-82 and 87-109 40041003368 Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826 40041003369 Peptidase family U32; Region: Peptidase_U32; pfam01136 40041003370 HMMPfam hit to PF01136, Peptidase U32, score 2.3e-76 40041003371 Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826 40041003372 Peptidase family U32; Region: Peptidase_U32; pfam01136 40041003373 HMMPfam hit to PF01136, Peptidase U32, score 1.1e-131 40041003374 PS01276 Peptidase family U32 signature. 40041003375 Uncharacterized protein conserved in bacteria (DUF2128); Region: DUF2128; pfam09901 40041003376 Ortholog of S. equi 4047 (FM204883) SEQ1528 40041003377 1 probable transmembrane helix predicted for SZO06230 by TMHMM2.0 at aa 13-35 40041003378 lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484 40041003379 LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322 40041003380 dimer interface [polypeptide binding]; other site 40041003381 putative anticodon binding site; other site 40041003382 Lys_tRNA synthetase (LysRS) class II core domain. Class II LysRS is a dimer which attaches a lysine to the 3' OH group of ribose of the appropriate tRNA. Its assignment to class II aaRS is based upon its structure and the presence of three...; Region: LysRS_core; cd00775 40041003383 motif 1; other site 40041003384 active site 40041003385 motif 2; other site 40041003386 motif 3; other site 40041003387 HMMPfam hit to PF00152, Aminoacyl-tRNA synthetase, class II (D, K and N), score 1.6e-119 40041003388 PS00339 Aminoacyl-transfer RNA synthetases class-II signature 2. 40041003389 PS00179 Aminoacyl-transfer RNA synthetases class-II signature 1. 40041003390 HMMPfam hit to PF01336, Nucleic acid binding, OB-fold, tRNA/helicase-type, score 1.6e-18 40041003391 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 40041003392 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 40041003393 putative substrate translocation pore; other site 40041003394 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 40041003395 14 probable transmembrane helices predicted for SZO06260 by TMHMM2.0 at aa 13-35, 55-74, 86-108, 113-135, 142-164, 174-196, 216-238, 242-259, 279-301, 316-338, 345-364, 374-396, 417-434 and 462-484 40041003396 HMMPfam hit to PF07690, Major facilitator superfamily MFS-1, score 3.6e-53 40041003397 PS00225 Crystallins beta and gamma 'Greek key' motif signature. 40041003398 Predicted hydrolase (HAD superfamily) [General function prediction only]; Region: COG1011 40041003399 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 40041003400 motif II; other site 40041003401 HMMPfam hit to PF00702, Haloacid dehalogenase-like hydrolase, score 9.1e-24 40041003402 LXG domain of WXG superfamily; Region: LXG; pfam04740 40041003403 Protein of unknown function (DUF4225); Region: DUF4225; pfam13988 40041003404 1 probable transmembrane helix predicted for SZO06290 by TMHMM2.0 at aa 259-281 40041003405 Possible gene remnant 40041003406 Probable gene remnant 40041003408 bifunctional N-succinyldiaminopimelate-aminotransferase/acetylornithine transaminase protein; Reviewed; Region: argD; PRK05093 40041003409 Ortholog of S. equi 4047 (FM204883) SEQ1514; CDS contains a frameshift 40041003410 Ortholog of S. equi 4047 (FM204883) SEQ1511; CDS contains a nonsense mutation (ochre) after codon 161 40041003411 RNA polymerase sigma factor, SigM family; Region: SigM_subfam; TIGR02950 40041003412 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 40041003413 DNA binding residues [nucleotide binding] 40041003414 HMMPfam hit to PF08281, RNA polymerase sigma factor 70, region 4 type 2, score 1.2e-18 40041003415 Predicted helix-turn-helix motif with score 983.000, SD 2.53 at aa 114-135, sequence LSVKEVASLLHWSVSSVKVNLM 40041003416 Sigma factor regulator C-terminal; Region: Sigma_reg_C; pfam13791 40041003417 1 probable transmembrane helix predicted for SZO06440 by TMHMM2.0 at aa 20-42 40041003418 Viral enhancin protein; Region: Enhancin; pfam03272 40041003419 Viral enhancin protein; Region: Enhancin; pfam03272 40041003420 elongation factor Tu; Reviewed; Region: PRK00049 40041003421 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 40041003422 G1 box; other site 40041003423 GEF interaction site [polypeptide binding]; other site 40041003424 GTP/Mg2+ binding site [chemical binding]; other site 40041003425 Switch I region; other site 40041003426 G2 box; other site 40041003427 G3 box; other site 40041003428 Switch II region; other site 40041003429 G4 box; other site 40041003430 G5 box; other site 40041003431 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 40041003432 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 40041003433 Antibiotic Binding Site [chemical binding]; other site 40041003434 HMMPfam hit to PF00009, Protein synthesis factor, GTP-binding, score 5.6e-101 40041003435 PS00017 ATP/GTP-binding site motif A (P-loop). 40041003436 PS00301 GTP-binding elongation factors signature. 40041003437 HMMPfam hit to PF03144, Translation elongation factor EFTu/EF1A, domain 2, score 1.1e-23 40041003438 HMMPfam hit to PF03143, Translation elongation factor EFTu/EF1A, C-terminal, score 3.6e-59 40041003439 triosephosphate isomerase; Provisional; Region: PRK14567 40041003440 Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311 40041003441 substrate binding site [chemical binding]; other site 40041003442 dimer interface [polypeptide binding]; other site 40041003443 catalytic triad [active] 40041003444 HMMPfam hit to PF00121, Triosephosphate isomerase, score 7.4e-138 40041003445 PS00171 Triosephosphate isomerase active site. 40041003446 FemAB family; Region: FemAB; pfam02388 40041003447 Acetyltransferase (GNAT) domain; Region: Acetyltransf_6; pfam13480 40041003448 HMMPfam hit to PF02388, Methicillin resistance protein, score 2.7e-120 40041003449 FemAB family; Region: FemAB; pfam02388 40041003450 Acetyltransferase (GNAT) domain; Region: Acetyltransf_6; pfam13480 40041003451 HMMPfam hit to PF02388, Methicillin resistance protein, score 8.1e-12 40041003452 sugar phosphate phosphatase; Provisional; Region: PRK10513 40041003453 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 40041003454 active site 40041003455 motif I; other site 40041003456 motif II; other site 40041003457 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 40041003458 HMMPfam hit to PF08282, HAD superfamily hydrolase-like, type 3, score 8.8e-104 40041003459 PS01229 Hypothetical cof family signature 2. 40041003460 PS01228 Hypothetical cof family signature 1. 40041003461 HD superfamily phosphohydrolases [General function prediction only]; Region: COG1078 40041003462 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 40041003463 Zn2+ binding site [ion binding]; other site 40041003464 Mg2+ binding site [ion binding]; other site 40041003465 PS00225 Crystallins beta and gamma 'Greek key' motif signature. 40041003466 HMMPfam hit to PF01966, Metal-dependent phosphohydrolase, HD region, subdomain, score 1.3e-08 40041003467 Domain of unknown function (DUF1934); Region: DUF1934; pfam09148 40041003468 HMMPfam hit to PF09148, Protein of unknown function DUF1934, score 4.9e-07 40041003469 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 40041003470 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; smart00831 40041003471 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 40041003472 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 40041003473 haloacid dehalogenase-like hydrolase; Region: HAD; pfam12710 40041003474 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 40041003475 HMMPfam hit to PF00690, ATPase, P-type cation-transporter, N-terminal, score 2.5e-27 40041003476 8 probable transmembrane helices predicted for SZO06530 by TMHMM2.0 at aa 65-82, 86-105, 253-275, 285-307, 682-704, 756-778, 827-849 and 859-881 40041003477 HMMPfam hit to PF00122, E1-E2 ATPase-associated region, score 7.3e-104 40041003478 HMMPfam hit to PF00702, Haloacid dehalogenase-like hydrolase, score 2e-20 40041003479 PS00154 E1-E2 ATPases phosphorylation site. 40041003480 HMMPfam hit to PF00689, ATPase, P-type cation-transporter, C-terminal, score 9.9e-18 40041003481 Transcriptional regulators [Transcription]; Region: PurR; COG1609 40041003482 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 40041003483 DNA binding site [nucleotide binding] 40041003484 domain linker motif; other site 40041003485 Ligand-binding domain of DNA transcription repressor RegR and other putative regulators such as KdgR and EndR; Region: PBP1_RegR_EndR_KdgR_like; cd06283 40041003486 putative dimerization interface [polypeptide binding]; other site 40041003487 putative ligand binding site [chemical binding]; other site 40041003488 HMMPfam hit to PF00532, Periplasmic binding protein/LacI transcriptional regulator, score 7.2e-06 40041003489 HMMPfam hit to PF00356, Bacterial regulatory protein, LacI, score 8.2e-07 40041003490 Predicted helix-turn-helix motif with score 1618.000, SD 4.70 at aa 5-26, sequence VTINDIADLAKTSKTTVSFYLN 40041003491 Phosphotransferase system, mannose/fructose/N-acetylgalactosamine-specific component IID [Carbohydrate transport and metabolism]; Region: ManZ; COG3716 40041003492 HMMPfam hit to PF03613, Phosphotransferase system, mannose/fructose/sorbose family IID component, score 2.1e-127 40041003493 5 probable transmembrane helices predicted for SZO06590 by TMHMM2.0 at aa 100-122, 137-159, 180-202, 228-245 and 250-272 40041003494 Phosphotransferase system, mannose/fructose/N-acetylgalactosamine-specific component IIC [Carbohydrate transport and metabolism]; Region: ManY; COG3715 40041003495 HMMPfam hit to PF03609, Phosphotransferase system, sorbose-specific IIC subunit, score 2.1e-98 40041003496 6 probable transmembrane helices predicted for SZO06600 by TMHMM2.0 at aa 5-27, 32-54, 97-119, 140-162, 177-199 and 211-233 40041003497 PTS_IIB, PTS system, Mannose/sorbose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_man; cd00001 40041003498 active site 40041003499 phosphorylation site [posttranslational modification] 40041003500 HMMPfam hit to PF03830, Phosphotransferase system, sorbose subfamily IIB component, score 2.5e-74 40041003501 Glycosyl Hydrolase Family 88; Region: Glyco_hydro_88; pfam07470 40041003502 HMMPfam hit to PF07470, Glycosyl hydrolase, family 88, score 2.5e-120 40041003503 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006 40041003504 active pocket/dimerization site; other site 40041003505 active site 40041003506 phosphorylation site [posttranslational modification] 40041003507 HMMPfam hit to PF03610, Phosphotransferase system, fructose subfamily IIA component, score 9.3e-39 40041003508 gluconate 5-dehydrogenase; Provisional; Region: PRK07097 40041003509 gluconate 5-dehydrogenase (Ga5DH)-like, classical (c) SDRs; Region: Ga5DH-like_SDR_c; cd05347 40041003510 NADP binding site [chemical binding]; other site 40041003511 homodimer interface [polypeptide binding]; other site 40041003512 active site 40041003513 HMMPfam hit to PF00106, Short-chain dehydrogenase/reductase SDR, score 1.5e-29 40041003514 PS00061 Short-chain dehydrogenases/reductases family signature. 40041003515 hypothetical protein; Provisional; Region: PRK09273 40041003516 Ribose 5-phosphate isomerase RpiB [Carbohydrate transport and metabolism]; Region: RpiB; COG0698 40041003517 Ribose-5-phosphate isomerase; Region: DUF3666; pfam12408 40041003518 HMMPfam hit to PF02502, Ribose/galactose isomerase, score 9.6e-36 40041003519 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 40041003520 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166 40041003521 substrate binding site [chemical binding]; other site 40041003522 ATP binding site [chemical binding]; other site 40041003523 HMMPfam hit to PF00294, Carbohydrate/purine kinase, score 2.6e-15 40041003524 HMMPfam hit to PF00294, Carbohydrate/purine kinase, score 4.6e-08 40041003525 2-keto-3-deoxy-6-phosphogluconate aldolase [Carbohydrate transport and metabolism]; Region: Eda; COG0800 40041003526 KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452 40041003527 active site 40041003528 intersubunit interface [polypeptide binding]; other site 40041003529 catalytic residue [active] 40041003530 HMMPfam hit to PF01081, KDPG and KHG aldolase, score 2.3e-31 40041003531 Glycosaminoglycan (GAG) polysaccharide lyase family. This family consists of a group of secreted bacterial lyase enzymes capable of acting on glycosaminoglycans, such as hyaluronan and chondroitin, in the extracellular matrix of host tissues; Region: GAG_Lyase; cd01083 40041003532 substrate binding site [chemical binding]; other site 40041003533 catalytic residues [active] 40041003534 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 40041003535 HMMPfam hit to PF08124, Polysaccharide lyase 8, N-terminal alpha-helical, score 7.2e-155 40041003536 HMMPfam hit to PF02278, Polysaccharide lyase family 8, central, score 1.7e-116 40041003537 HMMPfam hit to PF02884, Polysaccharide lyase family 8, C-terminal, score 0.00028 40041003538 12mer inverted repeat 40041003539 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 40041003540 Helix-turn-helix domain; Region: HTH_28; pfam13518 40041003541 Predicted helix-turn-helix motif with score 1140.000, SD 3.07 at aa 19-40, sequence KSIKCLSEKFSIAESDLKYMIR 40041003542 HMMPfam hit to PF01527, Transposase IS3/IS911, score 0.0011 40041003543 putative transposase OrfB; Reviewed; Region: PHA02517 40041003544 HTH-like domain; Region: HTH_21; pfam13276 40041003545 Integrase core domain; Region: rve; pfam00665 40041003546 Integrase core domain; Region: rve_2; pfam13333 40041003547 HMMPfam hit to PF00665, Integrase, catalytic core, score 7.9e-38 40041003548 2 probable transmembrane helices predicted for SZO06710 by TMHMM2.0 at aa 72-89 and 94-113 40041003549 Haloacid dehalogenase-like hydrolase; Region: HAD_2; pfam13419 40041003550 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 40041003551 motif II; other site 40041003552 HMMPfam hit to PF00702, Haloacid dehalogenase-like hydrolase, score 9.1e-27 40041003553 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 40041003554 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 40041003555 HMMPfam hit to PF00583, GCN5-related N-acetyltransferase, score 7.9e-05 40041003556 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 40041003557 Thioesterase-like superfamily; Region: 4HBT_3; pfam13622 40041003558 CoenzymeA binding site [chemical binding]; other site 40041003559 subunit interaction site [polypeptide binding]; other site 40041003560 PHB binding site; other site 40041003561 HMMPfam hit to PF03061, Thioesterase superfamily, score 1.3e-24 40041003562 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4868 40041003563 hypothetical protein; Provisional; Region: PRK13663 40041003564 HMMPfam hit to PF08903, Protein of unknown function DUF1846, score 0 40041003565 PS00017 ATP/GTP-binding site motif A (P-loop). 40041003566 benzoate transport; Region: 2A0115; TIGR00895 40041003567 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 40041003568 putative substrate translocation pore; other site 40041003569 12 probable transmembrane helices predicted for SZO06770 by TMHMM2.0 at aa 13-35, 50-69, 82-104, 108-130, 137-159, 163-185, 223-245, 260-279, 286-305, 311-333, 346-368 and 372-394 40041003570 HMMPfam hit to PF07690, Major facilitator superfamily MFS-1, score 2.5e-40 40041003571 Predicted thioesterase [General function prediction only]; Region: COG5496 40041003572 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 40041003573 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 40041003574 RNA binding surface [nucleotide binding]; other site 40041003575 Pseudouridine synthase, Escherichia coli RsuA like; Region: PseudoU_synth_RsuA; cd02553 40041003576 active site 40041003577 uracil binding [chemical binding]; other site 40041003578 HMMPfam hit to PF01479, RNA-binding S4, score 6.2e-11 40041003579 HMMPfam hit to PF00849, Pseudouridine synthase, score 1.1e-19 40041003580 PS01149 Rsu family of pseudouridine synthase signature. 40041003581 Thermophilic metalloprotease (M29); Region: Peptidase_M29; pfam02073 40041003582 Leucyl aminopeptidase (aminopeptidase T) [Amino acid transport and metabolism]; Region: AmpS; COG2309 40041003583 HMMPfam hit to PF02073, Peptidase M29, aminopeptidase II, score 4.1e-169 40041003584 GTPase CgtA; Reviewed; Region: obgE; PRK12297 40041003585 GTP1/OBG; Region: GTP1_OBG; pfam01018 40041003586 Obg GTPase; Region: Obg; cd01898 40041003587 G1 box; other site 40041003588 GTP/Mg2+ binding site [chemical binding]; other site 40041003589 Switch I region; other site 40041003590 G2 box; other site 40041003591 G3 box; other site 40041003592 Switch II region; other site 40041003593 G4 box; other site 40041003594 G5 box; other site 40041003595 Domain of unknown function (DUF1967); Region: DUF1967; pfam09269 40041003596 HMMPfam hit to PF01018, GTP1/OBG subdomain, score 7.5e-83 40041003597 HMMPfam hit to PF01926, GTP-binding protein, HSR1-related, score 4.4e-40 40041003598 PS00017 ATP/GTP-binding site motif A (P-loop). 40041003599 HMMPfam hit to PF09269, GTP1/OBG, C-terminal, score 3.6e-39 40041003600 Nicotinamide mononucleotide transporter; Region: NMN_transporter; pfam04973 40041003601 8 probable transmembrane helices predicted for SZO06830 by TMHMM2.0 at aa 12-29, 33-51, 56-78, 82-101, 122-139, 144-163, 170-192 and 197-219 40041003602 HMMPfam hit to PF04973, Nicotinamide mononucleotide transporter PnuC, score 1.3e-42 40041003603 Beta-glucosidase/6-phospho-beta-glucosidase/beta- galactosidase [Carbohydrate transport and metabolism]; Region: BglB; COG2723 40041003604 beta-galactosidase; Region: BGL; TIGR03356 40041003605 HMMPfam hit to PF00232, Glycoside hydrolase, family 1, score 6.6e-116 40041003606 Uncharacterized conserved protein [Function unknown]; Region: COG3589 40041003607 Bacterial protein of unknown function (DUF871); Region: DUF871; pfam05913 40041003608 HMMPfam hit to PF05913, Protein of unknown function DUF871, prokaryotic, score 2.1e-183 40041003609 Transcriptional antiterminator [Transcription]; Region: BglG; COG3711 40041003610 HTH domain; Region: HTH_11; pfam08279 40041003611 Mga helix-turn-helix domain; Region: Mga; pfam05043 40041003612 PRD domain; Region: PRD; pfam00874 40041003613 PRD domain; Region: PRD; pfam00874 40041003614 PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568 40041003615 active site 40041003616 P-loop; other site 40041003617 phosphorylation site [posttranslational modification] 40041003618 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cl00163 40041003619 active site 40041003620 phosphorylation site [posttranslational modification] 40041003621 HMMPfam hit to PF08279, Helix-turn-helix, type 11, score 1.6e-16 40041003622 Predicted helix-turn-helix motif with score 1653.000, SD 4.82 at aa 21-42, sequence VSSATLAKAIGMSDRTVRKYLK 40041003623 HMMPfam hit to PF05043, M trans-acting positive regulator, score 2.8e-21 40041003624 Predicted helix-turn-helix motif with score 1309.000, SD 3.65 at aa 114-135, sequence WDFEELCQELYISRTTLNHVLA 40041003625 HMMPfam hit to PF00874, PRD, score 2.1e-16 40041003626 HMMPfam hit to PF00874, PRD, score 2.4e-16 40041003627 HMMPfam hit to PF02302, Phosphotransferase system, lactose/cellobiose-specific IIB subunit, score 6.3e-05 40041003628 PTS_IIB_chitobiose_lichenan: subunit IIB of enzyme II (EII) of the N,N-diacetylchitobiose-specific and lichenan-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In these systems, EII is either a lichenan- or an N; Region: PTS_IIB_chitobiose_lichenan; cd05564 40041003629 active site 40041003630 P-loop; other site 40041003631 phosphorylation site [posttranslational modification] 40041003632 HMMPfam hit to PF02302, Phosphotransferase system, lactose/cellobiose-specific IIB subunit, score 2.3e-41 40041003633 PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_lac; cd00215 40041003634 active site 40041003635 methionine cluster; other site 40041003636 phosphorylation site [posttranslational modification] 40041003637 metal binding site [ion binding]; metal-binding site 40041003638 HMMPfam hit to PF02255, Phosphotransferase system, lactose/cellobiose-specific IIA subunit, score 6.5e-38 40041003639 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cd07812 40041003640 hydrophobic ligand binding site; other site 40041003641 Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455 40041003642 cellobiose phosphotransferase system IIC component; Reviewed; Region: celD; PRK09592 40041003643 HMMPfam hit to PF02378, Phosphotransferase system, EIIC, score 5.6e-61 40041003644 9 probable transmembrane helices predicted for SZO06900 by TMHMM2.0 at aa 27-49, 70-92, 167-189, 209-231, 251-273, 280-299, 319-341, 389-411 and 426-448 40041003645 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 40041003646 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 40041003647 Walker A/P-loop; other site 40041003648 ATP binding site [chemical binding]; other site 40041003649 Q-loop/lid; other site 40041003650 ABC transporter signature motif; other site 40041003651 Walker B; other site 40041003652 D-loop; other site 40041003653 H-loop/switch region; other site 40041003654 HMMPfam hit to PF00005, ABC transporter related, score 7.6e-66 40041003655 PS00211 ABC transporters family signature. 40041003656 PS00017 ATP/GTP-binding site motif A (P-loop). 40041003657 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 40041003658 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 40041003659 substrate binding pocket [chemical binding]; other site 40041003660 membrane-bound complex binding site; other site 40041003661 hinge residues; other site 40041003662 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 40041003663 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 40041003664 substrate binding pocket [chemical binding]; other site 40041003665 membrane-bound complex binding site; other site 40041003666 hinge residues; other site 40041003667 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 40041003668 dimer interface [polypeptide binding]; other site 40041003669 conserved gate region; other site 40041003670 putative PBP binding loops; other site 40041003671 ABC-ATPase subunit interface; other site 40041003672 HMMPfam hit to PF00528, Binding-protein-dependent transport systems inner membrane component, score 1e-28 40041003673 4 probable transmembrane helices predicted for SZO06920 by TMHMM2.0 at aa 518-540, 553-575, 595-617 and 691-713 40041003674 PS00402 Binding-protein-dependent transport systems inner membrane comp. sign. 40041003675 HMMPfam hit to PF00497, Bacterial extracellular solute-binding protein, family 3, score 4.8e-74 40041003676 HMMPfam hit to PF00497, Bacterial extracellular solute-binding protein, family 3, score 6.5e-74 40041003677 excinuclease ABC subunit B; Provisional; Region: PRK05298 40041003678 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 40041003679 ATP binding site [chemical binding]; other site 40041003680 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 40041003681 nucleotide binding region [chemical binding]; other site 40041003682 ATP-binding site [chemical binding]; other site 40041003683 Ultra-violet resistance protein B; Region: UvrB; pfam12344 40041003684 HMMPfam hit to PF04851, Restriction endonuclease, type I, R subunit/Type III, Res subunit, score 6.9e-13 40041003685 PS00017 ATP/GTP-binding site motif A (P-loop). 40041003686 HMMPfam hit to PF00271, DNA/RNA helicase, C-terminal, score 3.7e-21 40041003687 HMMPfam hit to PF02151, UvrB/UvrC protein, score 1.6e-08 40041003688 D-alanine--poly(phosphoribitol) ligase subunit 1; Provisional; Region: PRK04813 40041003689 D-alanine:D-alanyl carrier protein ligase (DltA); Region: DltA; cd05945 40041003690 acyl-activating enzyme (AAE) consensus motif; other site 40041003691 AMP binding site [chemical binding]; other site 40041003692 HMMPfam hit to PF00501, AMP-dependent synthetase and ligase, score 5e-113 40041003693 PS00455 AMP-binding domain signature. 40041003694 D-alanyl-lipoteichoic acid biosynthesis protein DltB; Region: LTA_dltB; TIGR04091 40041003695 7 probable transmembrane helices predicted for SZO06950 by TMHMM2.0 at aa 13-35, 50-72, 93-115, 197-219, 240-262, 340-362 and 383-405 40041003696 HMMPfam hit to PF03062, Membrane bound O-acyl transferase, MBOAT, score 7.9e-97 40041003697 D-alanine--poly(phosphoribitol) ligase subunit 2; Validated; Region: PRK05087 40041003698 Protein involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein) [Cell envelope biogenesis, outer membrane]; Region: DltD; COG3966 40041003699 DltD N-terminal region; Region: DltD_N; pfam04915 40041003700 DltD central region; Region: DltD_M; pfam04918 40041003701 DltD C-terminal region; Region: DltD_C; pfam04914 40041003702 1 probable transmembrane helix predicted for SZO06970 by TMHMM2.0 at aa 5-27 40041003703 HMMPfam hit to PF04915, DltD, N-terminal, score 3.4e-38 40041003704 HMMPfam hit to PF04918, DltD, central region, score 6.7e-69 40041003705 HMMPfam hit to PF04914, DltD, C-terminal, score 6.6e-81 40041003706 Protein of unknown function (DUF2424); Region: DUF2424; pfam10340 40041003707 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 40041003708 1 probable transmembrane helix predicted for SZO06980 by TMHMM2.0 at aa 5-22 40041003709 HMMPfam hit to PF07859, Alpha/beta hydrolase fold-3, score 2.5e-25 40041003710 Maltose-binding periplasmic proteins/domains [Carbohydrate transport and metabolism]; Region: MalE; COG2182 40041003711 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 40041003712 HMMPfam hit to PF01547, Bacterial extracellular solute-binding protein, family 1, score 8e-40 40041003713 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 40041003714 maltodextrin glucosidase; Provisional; Region: PRK10785 40041003715 N-terminal Early set domain associated with the catalytic domain of cyclomaltodextrinase and pullulan-degrading enzymes; Region: E_set_CDase_PDE_N; cd02857 40041003716 homodimer interface [polypeptide binding]; other site 40041003717 Alpha amylase catalytic domain found in cyclomaltodextrinases and related proteins; Region: AmyAc_CMD; cd11338 40041003718 active site 40041003719 homodimer interface [polypeptide binding]; other site 40041003720 catalytic site [active] 40041003721 HMMPfam hit to PF02903, Glycoside hydrolase, family 13, N-terminal Ig-like region, score 7.8e-08 40041003722 HMMPfam hit to PF00128, Glycosyl hydrolase, family 13, catalytic region, score 3.7e-93 40041003723 Alpha amylase catalytic domain found in maltogenic amylases, cyclodextrin glycosyltransferase, and related proteins; Region: AmyAc_AmyMalt_CGTase_like; cd11320 40041003724 Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366 40041003725 Ca binding site [ion binding]; other site 40041003726 active site 40041003727 catalytic site [active] 40041003728 Aamy_C domain; Region: Aamy_C; smart00632 40041003729 IPT domain (domain D) of cyclodextrin glycosyltransferase (CGTase) and similar enzymes. These enzymes are involved in the enzymatic hydrolysis of alpha-1,4 linkages of starch polymers and belong to the glycosyl hydrolase family 13. Most consist of three...; Region: IPT_CGTD; cd00604 40041003730 The family 20 carbohydrate-binding module (CBM20), also known as the starch-binding domain, is found in a large number of starch degrading enzymes including alpha-amylase, beta-amylase, glucoamylase, and CGTase (cyclodextrin glucanotransferase). CBM20 is...; Region: CBM20; cl15347 40041003731 starch-binding site 2 [chemical binding]; other site 40041003732 starch-binding site 1 [chemical binding]; other site 40041003733 HMMPfam hit to PF00128, Glycosyl hydrolase, family 13, catalytic region, score 1.5e-112 40041003734 PS00962 Ribosomal protein S2 signature 1. 40041003735 HMMPfam hit to PF02806, Alpha-amylase, C-terminal all beta, score 1e-07 40041003736 HMMPfam hit to PF01833, Cell surface receptor IPT/TIG, score 2.6e-09 40041003737 HMMPfam hit to PF00686, Glycoside hydrolase, carbohydrate-binding, score 2.2e-14 40041003738 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 40041003739 dimer interface [polypeptide binding]; other site 40041003740 conserved gate region; other site 40041003741 putative PBP binding loops; other site 40041003742 ABC-ATPase subunit interface; other site 40041003743 8 probable transmembrane helices predicted for SZO07020 by TMHMM2.0 at aa 34-56, 71-93, 127-149, 196-218, 230-252, 291-313, 338-357 and 401-423 40041003744 HMMPfam hit to PF00528, Binding-protein-dependent transport systems inner membrane component, score 2.2e-20 40041003745 PS00402 Binding-protein-dependent transport systems inner membrane comp. sign. 40041003746 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 40041003747 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 40041003748 dimer interface [polypeptide binding]; other site 40041003749 conserved gate region; other site 40041003750 putative PBP binding loops; other site 40041003751 ABC-ATPase subunit interface; other site 40041003752 5 probable transmembrane helices predicted for SZO07030 by TMHMM2.0 at aa 21-43, 81-103, 115-137, 142-164 and 250-272 40041003753 HMMPfam hit to PF00528, Binding-protein-dependent transport systems inner membrane component, score 4.8e-25 40041003754 PS00402 Binding-protein-dependent transport systems inner membrane comp. sign. 40041003755 Predicted integral membrane protein [Function unknown]; Region: COG5521 40041003756 4 probable transmembrane helices predicted for SZO07040 by TMHMM2.0 at aa 27-49, 176-198, 219-241 and 245-264 40041003757 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 40041003758 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 40041003759 dimer interface [polypeptide binding]; other site 40041003760 conserved gate region; other site 40041003761 putative PBP binding loops; other site 40041003762 ABC-ATPase subunit interface; other site 40041003763 HMMPfam hit to PF00528, Binding-protein-dependent transport systems inner membrane component, score 4.6e-18 40041003764 6 probable transmembrane helices predicted for SZO07050 by TMHMM2.0 at aa 9-31, 75-97, 110-129, 139-161, 182-204 and 242-264 40041003765 PS00402 Binding-protein-dependent transport systems inner membrane comp. sign. 40041003766 PS00041 Bacterial regulatory proteins, araC family signature. 40041003767 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 40041003768 dimer interface [polypeptide binding]; other site 40041003769 conserved gate region; other site 40041003770 ABC-ATPase subunit interface; other site 40041003771 HMMPfam hit to PF00528, Binding-protein-dependent transport systems inner membrane component, score 1.5e-12 40041003772 8 probable transmembrane helices predicted for SZO07060 by TMHMM2.0 at aa 47-69, 98-120, 162-184, 222-244, 257-279, 309-331, 352-374 and 419-441 40041003773 PS00402 Binding-protein-dependent transport systems inner membrane comp. sign. 40041003774 Maltose-binding periplasmic proteins/domains [Carbohydrate transport and metabolism]; Region: MalE; COG2182 40041003775 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 40041003776 HMMPfam hit to PF01547, Bacterial extracellular solute-binding protein, family 1, score 8.3e-26 40041003777 PS00017 ATP/GTP-binding site motif A (P-loop). 40041003778 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 40041003779 Transcriptional regulators [Transcription]; Region: PurR; COG1609 40041003780 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 40041003781 DNA binding site [nucleotide binding] 40041003782 domain linker motif; other site 40041003783 Ligand-binding domain of uncharacterized transcription regulator ycjW which is a member of the LacI-GalR family repressors; Region: PBP1_ycjW_transcription_regulator_like; cd06294 40041003784 putative dimerization interface [polypeptide binding]; other site 40041003785 putative ligand binding site [chemical binding]; other site 40041003786 HMMPfam hit to PF00356, Bacterial regulatory protein, LacI, score 8.2e-10 40041003787 Predicted helix-turn-helix motif with score 2360.000, SD 7.22 at aa 2-23, sequence VTIKDVALKAGVNPSTVSRVLK 40041003788 HMMPfam hit to PF00532, Periplasmic binding protein/LacI transcriptional regulator, score 4.9e-08 40041003789 4-alpha-glucanotransferase; Provisional; Region: PRK14508 40041003790 HMMPfam hit to PF02446, Glycoside hydrolase, family 77, score 9.4e-192 40041003791 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 40041003792 glycogen/starch/alpha-glucan phosphorylases; Region: P_ylase; TIGR02093 40041003793 PS00599 Aminotransferases class-II pyridoxal-phosphate attachment site. 40041003794 HMMPfam hit to PF00343, Glycosyl transferase, family 35, score 2.7e-183 40041003795 PS00102 Phosphorylase pyridoxal-phosphate attachment site. 40041003796 Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190 40041003797 active site 40041003798 HMMPfam hit to PF00485, Phosphoribulokinase/uridine kinase, score 6.1e-08 40041003799 PS00017 ATP/GTP-binding site motif A (P-loop). 40041003800 1 probable transmembrane helix predicted for SZO07120 by TMHMM2.0 at aa 7-29 40041003801 tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091 40041003802 tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324 40041003803 1 probable transmembrane helix predicted for SZO07130 by TMHMM2.0 at aa 7-29 40041003804 PS00017 ATP/GTP-binding site motif A (P-loop). 40041003805 HMMPfam hit to PF01715, tRNA isopentenyltransferase, score 1.5e-65 40041003806 GTP-binding protein HflX; Region: GTP_HflX; TIGR03156 40041003807 GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167 40041003808 HflX GTPase family; Region: HflX; cd01878 40041003809 G1 box; other site 40041003810 GTP/Mg2+ binding site [chemical binding]; other site 40041003811 Switch I region; other site 40041003812 G2 box; other site 40041003813 G3 box; other site 40041003814 Switch II region; other site 40041003815 G4 box; other site 40041003816 G5 box; other site 40041003817 HMMPfam hit to PF01926, GTP-binding protein, HSR1-related, score 2.6e-38 40041003818 PS00017 ATP/GTP-binding site motif A (P-loop). 40041003819 Galactose-1-phosphate uridyl transferase, N-terminal domain; Region: GalP_UDP_transf; pfam01087 40041003820 ribonuclease Z; Region: RNase_Z; TIGR02651 40041003821 HMMPfam hit to PF00753, Beta-lactamase-like, score 1.8e-13 40041003822 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 40041003823 classical (c) SDRs; Region: SDR_c; cd05233 40041003824 NAD(P) binding site [chemical binding]; other site 40041003825 active site 40041003826 HMMPfam hit to PF00106, Short-chain dehydrogenase/reductase SDR, score 1.7e-23 40041003827 PS00061 Short-chain dehydrogenases/reductases family signature. 40041003828 single-stranded-DNA-specific exonuclease RecJ; Region: recJ; TIGR00644 40041003829 DHH family; Region: DHH; pfam01368 40041003830 DHHA1 domain; Region: DHHA1; pfam02272 40041003831 Single-strand DNA-specific exonuclease, C terminal domain; Region: ssDNA-exonuc_C; cl11538 40041003832 HMMPfam hit to PF01368, Phosphoesterase, RecJ-like, score 1.3e-52 40041003833 HMMPfam hit to PF02272, Phosphoesterase, DHHA1, score 8.7e-12 40041003834 conserved hypothetical protein; Region: TIGR02328 40041003835 Pyrimidine dimer DNA glycosylase; Region: Pyr_excise; pfam03013 40041003836 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 40041003837 active site 40041003838 HMMPfam hit to PF00156, Phosphoribosyltransferase, score 2.3e-46 40041003839 PS00103 Purine/pyrimidine phosphoribosyl transferases signature. 40041003840 Putative primosome component and related proteins [DNA replication, recombination, and repair]; Region: DnaD; COG3935 40041003841 Replication initiation and membrane attachment; Region: DnaB_2; pfam07261 40041003842 HMMPfam hit to PF04271, DnaD and phage-associated region, score 2.6e-37 40041003843 Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177 40041003844 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 40041003845 minor groove reading motif; other site 40041003846 helix-hairpin-helix signature motif; other site 40041003847 substrate binding pocket [chemical binding]; other site 40041003848 active site 40041003849 iron-sulpphur binding domain in DNA-(apurinic or apyrimidinic site) lyase (subfamily of ENDO3); Region: FES; smart00525 40041003850 HMMPfam hit to PF00730, HhH-GPD, score 9.6e-20 40041003851 HMMPfam hit to PF00633, Helix-hairpin-helix motif, score 1.7e-09 40041003852 PS01155 Endonuclease III family signature. 40041003853 PS00290 Immunoglobulins and major histocompatibility complex proteins signature. 40041003854 Predicted SAM-dependent methyltransferase [General function prediction only]; Region: COG2384 40041003855 Family of unknown function (DUF633); Region: DUF633; pfam04816 40041003856 HMMPfam hit to PF04816, Protein of unknown function DUF633, score 5.2e-109 40041003857 Uncharacterized conserved protein [Function unknown]; Region: COG0327 40041003858 NIF3 (NGG1p interacting factor 3); Region: NIF3; pfam01784 40041003859 HMMPfam hit to PF01784, NGG1p interacting factor 3, NIF3, score 5e-94 40041003860 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 40041003861 HMMPfam hit to PF01266, FAD dependent oxidoreductase, score 9.6e-67 40041003862 G1P_TT_short is the short form of glucose-1-phosphate thymidylyltransferase; Region: G1P_TT_short; cd02538 40041003863 glucose-1-phosphate thymidylyltransferase, short form; Region: rmlA; TIGR01207 40041003864 substrate binding site; other site 40041003865 tetramer interface; other site 40041003866 HMMPfam hit to PF00483, Nucleotidyl transferase, score 5.1e-119 40041003867 dTDP-4-dehydrorhamnose 3,5-epimerase and related enzymes [Cell envelope biogenesis, outer membrane]; Region: RfbC; COG1898 40041003868 HMMPfam hit to PF00908, dTDP-4-dehydrorhamnose 3,5-epimerase related, score 3.1e-14 40041003869 dTDP-D-glucose 4,6-dehydratase [Cell envelope biogenesis, outer membrane]; Region: RfbB; COG1088 40041003870 dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246 40041003871 NAD binding site [chemical binding]; other site 40041003872 substrate binding site [chemical binding]; other site 40041003873 homodimer interface [polypeptide binding]; other site 40041003874 active site 40041003875 HMMPfam hit to PF01370, NAD-dependent epimerase/dehydratase, score 6e-79 40041003876 MutT homolog-1 (MTH1) is a member of the Nudix hydrolase superfamily. MTH1, the mammalian counterpart of MutT, hydrolyzes oxidized purine nucleoside triphosphates, such as 8-oxo-dGTP and 2-hydroxy-ATP, to monophosphates, thereby preventing the...; Region: MTH1; cd03427 40041003877 putative active site [active] 40041003878 nucleotide binding site [chemical binding]; other site 40041003879 nudix motif; other site 40041003880 putative metal binding site [ion binding]; other site 40041003881 HMMPfam hit to PF00293, NUDIX hydrolase, core, score 4.5e-29 40041003882 PS00893 mutT domain signature. 40041003883 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 40041003884 Domain of unknown function DUF20; Region: UPF0118; pfam01594 40041003885 7 probable transmembrane helices predicted for SZO07300 by TMHMM2.0 at aa 18-40, 49-71, 86-108, 178-200, 242-264, 271-293 and 332-354 40041003886 HMMPfam hit to PF01594, Protein of unknown function UPF0118, score 1.8e-71 40041003887 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 40041003888 TPR motif; other site 40041003889 binding surface 40041003890 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 40041003891 binding surface 40041003892 TPR motif; other site 40041003893 HMMPfam hit to PF00515, Tetratricopeptide TPR-1, score 0.083 40041003894 HMMPfam hit to PF07719, Tetratricopeptide TPR2, score 7.9e-05 40041003895 Predicted RNA-binding protein homologous to eukaryotic snRNP [Transcription]; Region: COG1293 40041003896 Domain of unknown function (DUF814); Region: DUF814; pfam05670 40041003897 HMMPfam hit to PF05670, Protein of unknown function DUF814, score 1.6e-37 40041003898 HMMPfam hit to PF05833, Fibronectin-binding A, N-terminal, score 7.6e-229 40041003899 Type I periplasmic ligand-binding domain of uncharacterized ABC-type transport systems that are predicted to be involved in the uptake of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_uncharacterized_transporter; cd06325 40041003900 zinc binding site [ion binding]; other site 40041003901 putative ligand binding site [chemical binding]; other site 40041003902 1 probable transmembrane helix predicted for SZO07330 by TMHMM2.0 at aa 5-23 40041003903 HMMPfam hit to PF04392, ABC transporter substrate binding protein, score 1.8e-129 40041003904 Transmembrane subunit (TM) of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which are involved in the uptake of branched-chain amino acids (AAs), as well as TMs of transporters involved in the uptake of...; Region: TM_PBP1_branched-chain-AA_like; cd06574 40041003905 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 40041003906 TM-ABC transporter signature motif; other site 40041003907 HMMPfam hit to PF02653, Bacterial inner-membrane translocator, score 3.6e-22 40041003908 8 probable transmembrane helices predicted for SZO07340 by TMHMM2.0 at aa 9-28, 54-76, 83-105, 125-147, 176-195, 205-227, 234-256 and 260-282 40041003909 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 40041003910 ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: PhnK; COG1101 40041003911 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 40041003912 Walker A/P-loop; other site 40041003913 ATP binding site [chemical binding]; other site 40041003914 Q-loop/lid; other site 40041003915 ABC transporter signature motif; other site 40041003916 Walker B; other site 40041003917 D-loop; other site 40041003918 H-loop/switch region; other site 40041003919 HMMPfam hit to PF00005, ABC transporter related, score 2e-43 40041003920 PS00017 ATP/GTP-binding site motif A (P-loop). 40041003921 PS00211 ABC transporters family signature. 40041003922 mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595 40041003923 Metallo-beta-lactamase superfamily; Region: Lactamase_B; pfam00753 40041003924 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 40041003925 HMMPfam hit to PF00753, Beta-lactamase-like, score 7.3e-25 40041003926 HMMPfam hit to PF07521, RNA-metabolising metallo-beta-lactamase, score 3.1e-11 40041003927 Predicted esterase [General function prediction only]; Region: COG0627 40041003928 S-formylglutathione hydrolase; Region: PLN02442 40041003929 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819 40041003930 HMMPfam hit to PF00756, esterase, score 1.3e-05 40041003931 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 40041003932 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 40041003933 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 40041003934 ABC transporter; Region: ABC_tran_2; pfam12848 40041003935 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 40041003936 HMMPfam hit to PF00005, ABC transporter related, score 7.6e-46 40041003937 PS00017 ATP/GTP-binding site motif A (P-loop). 40041003938 HMMPfam hit to PF00005, ABC transporter related, score 5.6e-34 40041003939 PS00017 ATP/GTP-binding site motif A (P-loop). 40041003940 PS00211 ABC transporters family signature. 40041003941 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, alpha subunit [Energy production and conversion]; Region: AcoA; COG1071 40041003942 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 40041003943 tetramer interface [polypeptide binding]; other site 40041003944 TPP-binding site [chemical binding]; other site 40041003945 heterodimer interface [polypeptide binding]; other site 40041003946 phosphorylation loop region [posttranslational modification] 40041003947 HMMPfam hit to PF00676, Dehydrogenase, E1 component, score 1.1e-107 40041003948 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 40041003949 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 40041003950 alpha subunit interface [polypeptide binding]; other site 40041003951 TPP binding site [chemical binding]; other site 40041003952 heterodimer interface [polypeptide binding]; other site 40041003953 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 40041003954 HMMPfam hit to PF02779, Transketolase, central region, score 1.3e-60 40041003955 HMMPfam hit to PF02780, Transketolase, C-terminal, score 9e-55 40041003956 branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856 40041003957 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 40041003958 E3 interaction surface; other site 40041003959 lipoyl attachment site [posttranslational modification]; other site 40041003960 e3 binding domain; Region: E3_binding; pfam02817 40041003961 e3 binding domain; Region: E3_binding; pfam02817 40041003962 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 40041003963 HMMPfam hit to PF00364, Biotin/lipoyl attachment, score 4.3e-21 40041003964 PS00189 2-oxo acid dehydrogenases acyltransferase component lipoyl binding site. 40041003965 HMMPfam hit to PF02817, E3 binding, score 3.7e-15 40041003966 HMMPfam hit to PF02817, E3 binding, score 9.7e-16 40041003967 HMMPfam hit to PF00198, Catalytic domain of components of various dehydrogenase complexes, score 1.4e-115 40041003968 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 40041003969 E3 interaction surface; other site 40041003970 lipoyl attachment site [posttranslational modification]; other site 40041003971 dihydrolipoamide dehydrogenase; Region: lipoamide_DH; TIGR01350 40041003972 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 40041003973 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 40041003974 HMMPfam hit to PF00364, Biotin/lipoyl attachment, score 1.6e-22 40041003975 PS00189 2-oxo acid dehydrogenases acyltransferase component lipoyl binding site. 40041003976 HMMPfam hit to PF07992, FAD-dependent pyridine nucleotide-disulphide oxidoreductase, score 4.5e-60 40041003977 PS00076 Pyridine nucleotide-disulphide oxidoreductases class-I active site. 40041003978 HMMPfam hit to PF00070, Pyridine nucleotide-disulphide oxidoreductase, NAD-binding region, score 5.7e-29 40041003979 HMMPfam hit to PF02852, Pyridine nucleotide-disulphide oxidoreductase dimerisation region, score 1e-52 40041003980 Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095 40041003981 lipoyltransferase and lipoate-protein ligase; Region: lipoyltrans; TIGR00545 40041003982 Bacterial lipoate protein ligase C-terminus; Region: Lip_prot_lig_C; pfam10437 40041003983 HMMPfam hit to PF03099, Biotin/lipoate A/B protein ligase, score 1.4e-21 40041003984 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyric Acid Synthase (CobQ); Region: GATase1_CobQ; cd01750 40041003985 catalytic triad [active] 40041003986 HMMPfam hit to PF07685, CobB/CobQ-like glutamine amidotransferase, score 2.5e-50 40041003987 UDP-N-acetylmuramyl tripeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurE; COG0769 40041003988 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 40041003989 Domain of unknown function (DUF1727); Region: DUF1727; pfam08353 40041003990 HMMPfam hit to PF08353, Region of unknown function DUF1727, score 3.6e-54 40041003991 HMMPfam hit to PF08245, Mur ligase, central, score 8.3e-07 40041003992 Uncharacterized conserved protein [Function unknown]; Region: COG1624 40041003993 DisA bacterial checkpoint controller nucleotide-binding; Region: DisA_N; pfam02457 40041003994 3 probable transmembrane helices predicted for SZO07470 by TMHMM2.0 at aa 15-37, 49-71 and 81-100 40041003995 HMMPfam hit to PF02457, Protein of unknown function DUF147, score 8.5e-59 40041003996 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4856 40041003997 YbbR-like protein; Region: YbbR; pfam07949 40041003998 YbbR-like protein; Region: YbbR; pfam07949 40041003999 1 probable transmembrane helix predicted for SZO07480 by TMHMM2.0 at aa 7-29 40041004000 HMMPfam hit to PF07949, YbbR-like, score 1.9e-13 40041004001 HMMPfam hit to PF07949, YbbR-like, score 9.9e-13 40041004002 HMMPfam hit to PF07949, YbbR-like, score 0.00013 40041004003 phosphoglucosamine mutase; Provisional; Region: glmM; PRK14316 40041004004 GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802 40041004005 active site 40041004006 substrate binding site [chemical binding]; other site 40041004007 metal binding site [ion binding]; metal-binding site 40041004008 HMMPfam hit to PF02878, Phosphoglucomutase/phosphomannomutase alpha/beta/alpha domain I, score 1.7e-59 40041004009 PS00710 Phosphoglucomutase and phosphomannomutase phosphoserine signature. 40041004010 HMMPfam hit to PF02879, Phosphoglucomutase/phosphomannomutase alpha/beta/alpha domain II, score 1e-19 40041004011 HMMPfam hit to PF02880, Phosphoglucomutase/phosphomannomutase alpha/beta/alpha domain III, score 4e-25 40041004012 HMMPfam hit to PF00408, Phosphoglucomutase/phosphomannomutase C-terminal, score 1.6e-08 40041004013 Acetyltransferase (GNAT) domain; Region: Acetyltransf_8; pfam13523 40041004014 coproporphyrinogen III oxidase; Provisional; Region: PRK08599 40041004015 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 40041004016 FeS/SAM binding site; other site 40041004017 HemN C-terminal domain; Region: HemN_C; pfam06969 40041004018 HMMPfam hit to PF04055, Radical SAM, score 3.9e-29 40041004019 HMMPfam hit to PF06969, HemN, C-terminal, score 6.1e-45 40041004020 Acyl-ACP thioesterase; Region: Acyl-ACP_TE; pfam01643 40041004021 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 40041004022 active site 40041004023 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 40041004024 active site 1 [active] 40041004025 HMMPfam hit to PF01643, Acyl-ACP thioesterase, score 2.3e-92 40041004026 HAD-superfamily subfamily IIA hydrolase, TIGR01457; Region: HAD-SF-IIA-hyp2 40041004027 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 40041004028 active site 40041004029 motif I; other site 40041004030 motif II; other site 40041004031 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 40041004032 HMMPfam hit to PF00702, Haloacid dehalogenase-like hydrolase, score 1e-22 40041004033 Protein of unknown function (DUF1461); Region: DUF1461; cl01862 40041004034 HMMPfam hit to PF07314, Integral membrane protein 1906, score 1.5e-78 40041004035 4 probable transmembrane helices predicted for SZO07540 by TMHMM2.0 at aa 7-29, 91-113, 125-144 and 178-200 40041004036 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 40041004037 PS00225 Crystallins beta and gamma 'Greek key' motif signature. 40041004038 Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797 40041004039 23S rRNA interface [nucleotide binding]; other site 40041004040 Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site 40041004041 HMMPfam hit to PF00466, Ribosomal protein L10, score 2.2e-28 40041004042 Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387 40041004043 core dimer interface [polypeptide binding]; other site 40041004044 L10 interface [polypeptide binding]; other site 40041004045 L11 interface [polypeptide binding]; other site 40041004046 putative EF-Tu interaction site [polypeptide binding]; other site 40041004047 putative EF-G interaction site [polypeptide binding]; other site 40041004048 HMMPfam hit to PF00542, Ribosomal protein L7/L12, C-terminal, score 4.4e-37 40041004049 genomic island 40041004050 Probable gene remnant. CDS contains a frameshift after codon 84 40041004051 HMMPfam hit to PF06970, Replication initiator A, N-terminal, score 2.1e-41 40041004052 Probable gene remnant 40041004053 HMMPfam hit to PF05713, Bacterial mobilisation, score 6.8e-12 40041004054 Probable gene remnant 40041004055 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 40041004056 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 40041004057 dimer interface [polypeptide binding]; other site 40041004058 phosphorylation site [posttranslational modification] 40041004059 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 40041004060 ATP binding site [chemical binding]; other site 40041004061 Mg2+ binding site [ion binding]; other site 40041004062 G-X-G motif; other site 40041004063 HMMPfam hit to PF02518, ATP-binding region, ATPase-like, score 1.3e-14 40041004064 HMMPfam hit to PF00512, Histidine kinase A, N-terminal, score 4.2e-12 40041004065 2 probable transmembrane helices predicted for SZO07620 by TMHMM2.0 at aa 11-33 and 152-174 40041004066 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 40041004067 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 40041004068 active site 40041004069 phosphorylation site [posttranslational modification] 40041004070 intermolecular recognition site; other site 40041004071 dimerization interface [polypeptide binding]; other site 40041004072 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 40041004073 DNA binding site [nucleotide binding] 40041004074 HMMPfam hit to PF00486, Transcriptional regulatory protein, C-terminal, score 8.9e-17 40041004075 HMMPfam hit to PF00072, Response regulator receiver, score 1.3e-29 40041004076 2 probable transmembrane helices predicted for SZO07640 by TMHMM2.0 at aa 24-46 and 56-78 40041004077 CDS contains a frameshift after codon 168. Frameshift occurs at a poly A nonamer 40041004078 HMMPfam hit to PF05147, Lanthionine synthetase C-like, score 8.2e-57 40041004079 ABC-type bacteriocin/lantibiotic exporters, contain an N-terminal double-glycine peptidase domain [Defense mechanisms]; Region: SunT; COG2274 40041004080 A sub-family of peptidase family C39. Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various...; Region: Peptidase_C39F; cd02425 40041004081 putative active site [active] 40041004082 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 40041004083 ATP-binding cassette domain of multidrug resistance protein-like transporters; Region: ABCC_MRP_Like; cd03228 40041004084 Walker A/P-loop; other site 40041004085 ATP binding site [chemical binding]; other site 40041004086 Q-loop/lid; other site 40041004087 ABC transporter signature motif; other site 40041004088 Walker B; other site 40041004089 D-loop; other site 40041004090 H-loop/switch region; other site 40041004091 HMMPfam hit to PF03412, Peptidase C39, bacteriocin processing, score 9.5e-49 40041004092 HMMPfam hit to PF00664, ABC transporter, transmembrane region, score 3.6e-07 40041004093 5 probable transmembrane helices predicted for SZO07670 by TMHMM2.0 at aa 173-192, 202-224, 280-302, 306-325 and 394-416 40041004094 HMMPfam hit to PF00005, ABC transporter related, score 1.1e-42 40041004095 PS00017 ATP/GTP-binding site motif A (P-loop). 40041004096 PS00211 ABC transporters family signature. 40041004097 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 40041004098 ATP-binding cassette domain of the bacitracin-resistance transporter; Region: ABC_BcrA_bacitracin_resist; cd03268 40041004099 Walker A/P-loop; other site 40041004100 ATP binding site [chemical binding]; other site 40041004101 Q-loop/lid; other site 40041004102 ABC transporter signature motif; other site 40041004103 Walker B; other site 40041004104 D-loop; other site 40041004105 H-loop/switch region; other site 40041004106 HMMPfam hit to PF00005, ABC transporter related, score 1.4e-52 40041004107 PS00017 ATP/GTP-binding site motif A (P-loop). 40041004108 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 40041004109 6 probable transmembrane helices predicted for SZO07690 by TMHMM2.0 at aa 17-39, 59-76, 101-123, 138-160, 165-187 and 221-243 40041004110 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4200 40041004111 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 40041004112 6 probable transmembrane helices predicted for SZO07700 by TMHMM2.0 at aa 17-36, 56-78, 104-126, 141-163, 168-190 and 210-232 40041004113 CDS contains a 143 bp internal deletion 40041004114 HMMPfam hit to PF01797, Transposase IS200-like, score 2.2e-11 40041004115 HMMPfam hit to PF01797, Transposase IS200-like, score 5.5e-08 40041004116 putative transposase OrfB; Reviewed; Region: PHA02517 40041004117 HTH-like domain; Region: HTH_21; pfam13276 40041004118 Integrase core domain; Region: rve; pfam00665 40041004119 Integrase core domain; Region: rve_2; pfam13333 40041004120 HMMPfam hit to PF00665, Integrase, catalytic core, score 7.9e-38 40041004121 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 40041004122 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 40041004123 Helix-turn-helix domain; Region: HTH_28; pfam13518 40041004124 HMMPfam hit to PF01527, Transposase IS3/IS911, score 0.0011 40041004125 Predicted helix-turn-helix motif with score 1140.000, SD 3.07 at aa 19-40, sequence KSIKCLSEKFSIAESDLKYMIR 40041004126 Ortholog of S. equi 4047 (FM204883) SEQ1387 40041004127 HMMPfam hit to PF01797, Transposase IS200-like, score 2.4e-55 40041004128 COMC family; Region: ComC; pfam03047 40041004129 HMMPfam hit to PF08128, Double glycine cleavage site bacteriocin, score 2.7e-11 40041004130 Ortholog of S. equi 4047 (FM204883) SEQ1385 40041004131 Ortholog of S. equi 4047 (FM204883) SEQ1383 40041004132 HMMPfam hit to PF00005, ABC transporter related, score 6.9e-31 40041004133 Ortholog of S. equi 4047 (FM204883) SEQ1382; CDS contains a double glycine clevage motif 40041004134 Enterocin A Immunity; Region: EntA_Immun; pfam08951 40041004135 HMMPfam hit to PF08957, Protein of unknown function DUF1862, score 2.3e-05 40041004137 2 probable transmembrane helices predicted for SZO07810 by TMHMM2.0 at aa 27-46 and 59-81 40041004138 GTP-binding protein LepA; Provisional; Region: PRK05433 40041004139 LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890 40041004140 G1 box; other site 40041004141 putative GEF interaction site [polypeptide binding]; other site 40041004142 GTP/Mg2+ binding site [chemical binding]; other site 40041004143 Switch I region; other site 40041004144 G2 box; other site 40041004145 G3 box; other site 40041004146 Switch II region; other site 40041004147 G4 box; other site 40041004148 G5 box; other site 40041004149 lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699 40041004150 lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane. LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709 40041004151 GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421 40041004152 HMMPfam hit to PF00009, Protein synthesis factor, GTP-binding, score 2.7e-71 40041004153 PS00017 ATP/GTP-binding site motif A (P-loop). 40041004154 PS00301 GTP-binding elongation factors signature. 40041004155 HMMPfam hit to PF03144, Translation elongation factor EFTu/EF1A, domain 2, score 8.5e-07 40041004156 HMMPfam hit to PF00679, Translation elongation factor EFG/EF2, C-terminal, score 3.6e-41 40041004157 HMMPfam hit to PF06421, GTP-binding protein LepA, C-terminal, score 2.5e-82 40041004158 methionine sulfoxide reductase B; Provisional; Region: PRK00222 40041004159 SelR domain; Region: SelR; pfam01641 40041004160 HMMPfam hit to PF01641, Methionine sulphoxide reductase B, score 3.3e-78 40041004161 Predicted membrane protein [Function unknown]; Region: COG2855 40041004162 HMMPfam hit to PF03601, Conserved hypothetical protein CHP00698, score 7.1e-131 40041004163 8 probable transmembrane helices predicted for SZO07850 by TMHMM2.0 at aa 22-44, 57-79, 84-106, 118-140, 150-172, 257-279, 289-308 and 315-337 40041004164 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cl00025 40041004165 active pocket/dimerization site; other site 40041004166 active site 40041004167 phosphorylation site [posttranslational modification] 40041004168 HMMPfam hit to PF03610, Phosphotransferase system, fructose subfamily IIA component, score 0.00028 40041004169 PTS system sorbose subfamily IIB component; Region: PTSIIB_sorb; pfam03830 40041004170 active site 40041004171 phosphorylation site [posttranslational modification] 40041004172 HMMPfam hit to PF03830, Phosphotransferase system, sorbose subfamily IIB component, score 6.9e-71 40041004173 Phosphotransferase system, mannose/fructose/N-acetylgalactosamine-specific component IIC [Carbohydrate transport and metabolism]; Region: ManY; COG3715 40041004174 HMMPfam hit to PF03609, Phosphotransferase system, sorbose-specific IIC subunit, score 8.8e-38 40041004175 7 probable transmembrane helices predicted for SZO07880 by TMHMM2.0 at aa 4-23, 30-52, 62-84, 96-118, 143-165, 178-200 and 210-232 40041004176 Phosphotransferase system, mannose/fructose/N-acetylgalactosamine-specific component IID [Carbohydrate transport and metabolism]; Region: ManZ; COG3716 40041004177 HMMPfam hit to PF03613, Phosphotransferase system, mannose/fructose/sorbose family IID component, score 7.2e-136 40041004178 5 probable transmembrane helices predicted for SZO07890 by TMHMM2.0 at aa 35-52, 126-148, 155-174, 232-249 and 256-274 40041004179 Predicted signal transduction protein with a C-terminal ATPase domain [Signal transduction mechanisms]; Region: COG2972 40041004180 Histidine kinase; Region: His_kinase; pfam06580 40041004181 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 40041004182 Mg2+ binding site [ion binding]; other site 40041004183 G-X-G motif; other site 40041004184 2 probable transmembrane helices predicted for SZO07900 by TMHMM2.0 at aa 21-43 and 254-276 40041004185 HMMPfam hit to PF06580, Histidine kinase internal region, score 1.4e-30 40041004186 HMMPfam hit to PF02518, ATP-binding region, ATPase-like, score 1.4e-06 40041004187 Response regulator receiver domain; Region: Response_reg; pfam00072 40041004188 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 40041004189 active site 40041004190 phosphorylation site [posttranslational modification] 40041004191 intermolecular recognition site; other site 40041004192 dimerization interface [polypeptide binding]; other site 40041004193 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 40041004194 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 40041004195 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 40041004196 HMMPfam hit to PF00072, Response regulator receiver, score 6.3e-20 40041004197 HMMPfam hit to PF00165, Helix-turn-helix, AraC type, score 6.8e-10 40041004198 Predicted helix-turn-helix motif with score 1260.000, SD 3.48 at aa 165-186, sequence IMIGQLAHDLGYSESHLYHLAK 40041004199 HMMPfam hit to PF00165, Helix-turn-helix, AraC type, score 6.7e-06 40041004200 ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840 40041004201 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 40041004202 HMMPfam hit to PF01547, Bacterial extracellular solute-binding protein, family 1, score 9.1e-09 40041004203 1 probable transmembrane helix predicted for SZO07920 by TMHMM2.0 at aa 7-26 40041004204 excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558 40041004205 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 40041004206 GIY-YIG motif/motif A; other site 40041004207 active site 40041004208 catalytic site [active] 40041004209 putative DNA binding site [nucleotide binding]; other site 40041004210 metal binding site [ion binding]; metal-binding site 40041004211 UvrB/uvrC motif; Region: UVR; pfam02151 40041004212 UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459 40041004213 HMMPfam hit to PF01541, Excinuclease ABC, C subunit, N-terminal, score 2.7e-33 40041004214 HMMPfam hit to PF02151, UvrB/UvrC protein, score 8.8e-09 40041004215 HMMPfam hit to PF08459, Excinuclease ABC, C subunit, C-terminal, score 5.7e-88 40041004216 Nitroreductase-like family 1. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_1; cd02137 40041004217 dimer interface [polypeptide binding]; other site 40041004218 FMN binding site [chemical binding]; other site 40041004219 HMMPfam hit to PF00881, Nitroreductase, score 8.2e-18 40041004220 dipeptidase PepV; Reviewed; Region: PRK07318 40041004221 M20 Peptidase Xaa-His dipeptidase (PepV) degrades hydrophobic dipeptides; Region: M20_PepV; cd03888 40041004222 active site 40041004223 metal binding site [ion binding]; metal-binding site 40041004224 PS00758 ArgE / dapE / ACY1 / CPG2 / yscS family signature 1. 40041004225 HMMPfam hit to PF01546, Peptidase M20, score 3.6e-32 40041004226 PS00759 ArgE / dapE / ACY1 / CPG2 / yscS family signature 2. 40041004227 tRNA modification GTPase TrmE; Reviewed; Region: trmE; PRK05291 40041004228 GTP-binding protein TrmE N-terminus; Region: TrmE_N; pfam10396 40041004229 trmE is a tRNA modification GTPase; Region: trmE; cd04164 40041004230 G1 box; other site 40041004231 GTP/Mg2+ binding site [chemical binding]; other site 40041004232 Switch I region; other site 40041004233 G2 box; other site 40041004234 Switch II region; other site 40041004235 G3 box; other site 40041004236 G4 box; other site 40041004237 G5 box; other site 40041004238 Catalytic cysteine-containing C-terminus of GTPase, MnmE; Region: GTPase_Cys_C; pfam12631 40041004239 HMMPfam hit to PF01926, GTP-binding protein, HSR1-related, score 1.2e-45 40041004240 PS00017 ATP/GTP-binding site motif A (P-loop). 40041004241 Ortholog of S. equi 4047 (FM204883) SEQ1364; Probable gene remnant. Similar to the C-terminal region of Streptococcus agalactiae serotype Ia uncharacterized protein UniProt:Q3K164 (EMBL:CP000114) (104 aa) fasta scores: E()=1.3e-14, 50.0% id in 74 aa 40041004242 type VII secretion effector, SACOL2603 family; Region: T7SS_SACOL2603; TIGR04197 40041004243 Ortholog of S. equi 4047 (FM204883) SEQ1361; CDS contains a frameshift after codon 133 40041004244 1 probable transmembrane helix predicted for SZO08000 by TMHMM2.0 at aa 488-510 40041004245 4 probable transmembrane helices predicted for SZO08010 by TMHMM2.0 at aa 51-73, 88-110, 152-174 and 189-211 40041004246 4 probable transmembrane helices predicted for SZO08020 by TMHMM2.0 at aa 53-75, 90-112, 150-172 and 187-206 40041004247 4 probable transmembrane helices predicted for SZO08030 by TMHMM2.0 at aa 52-74, 89-111, 153-175 and 185-206 40041004248 4 probable transmembrane helices predicted for SZO08040 by TMHMM2.0 at aa 52-74, 89-111, 151-173 and 188-210 40041004249 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 40041004250 4 probable transmembrane helices predicted for SZO08050 by TMHMM2.0 at aa 53-75, 90-112, 150-172 and 185-207 40041004251 Domain of unknown function (DUF4176); Region: DUF4176; pfam13780 40041004252 RPI_A: Ribose 5-phosphate isomerase type A (RPI_A) subfamily; RPI catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate, the first step of the non-oxidative branch of the pentose phosphate pathway. This reaction leads to the...; Region: RPI_A; cd01398 40041004253 tetramer (dimer of dimers) interface [polypeptide binding]; other site 40041004254 active site 40041004255 dimer interface [polypeptide binding]; other site 40041004256 HMMPfam hit to PF06026, Ribose 5-phosphate isomerase, score 1.1e-94 40041004257 phosphopentomutase; Provisional; Region: PRK05362 40041004258 Metalloenzyme superfamily; Region: Metalloenzyme; pfam01676 40041004259 HMMPfam hit to PF08342, Phosphopentomutase N-terminal, score 9.3e-47 40041004260 HMMPfam hit to PF01676, Metalloenzyme, score 4.7e-32 40041004261 purine nucleoside phosphorylase; Provisional; Region: PRK08202 40041004262 HMMPfam hit to PF00896, Purine phosphorylase, family 2, score 1.4e-100 40041004263 PS01240 Purine and other phosphorylases family 2 signature. 40041004264 CRISPR/Cas system-associated protein Csm6; Region: Csm6_III-A; cl09873 40041004265 Transcriptional regulator [Transcription]; Region: LysR; COG0583 40041004266 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 40041004267 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 40041004268 dimerization interface [polypeptide binding]; other site 40041004269 HMMPfam hit to PF00126, Bacterial regulatory protein, LysR, score 3.8e-19 40041004270 PS00044 Bacterial regulatory proteins, lysR family signature. 40041004271 Predicted helix-turn-helix motif with score 1543.000, SD 4.44 at aa 16-37, sequence GSMNEAAKQLFITQPSLSNAVK 40041004272 Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725 40041004273 active site 40041004274 dimer interface [polypeptide binding]; other site 40041004275 HMMPfam hit to PF00215, Orotidine 5'-phosphate decarboxylase, core, score 8.3e-77 40041004276 PS00156 Orotidine 5'-phosphate decarboxylase active site. 40041004277 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 40041004278 active site 40041004279 HMMPfam hit to PF00156, Phosphoribosyltransferase, score 5.7e-28 40041004280 PS00626 Regulator of chromosome condensation (RCC1) signature 2. 40041004281 PS00103 Purine/pyrimidine phosphoribosyl transferases signature. 40041004282 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 40041004283 Coenzyme A binding pocket [chemical binding]; other site 40041004284 HMMPfam hit to PF00583, GCN5-related N-acetyltransferase, score 7.9e-12 40041004285 amidase; Provisional; Region: PRK06529 40041004286 Amidase; Region: Amidase; cl11426 40041004287 HMMPfam hit to PF01425, Amidase signature enzyme, score 3.8e-68 40041004288 PS00571 Amidases signature. 40041004289 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 40041004290 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 40041004291 substrate binding pocket [chemical binding]; other site 40041004292 membrane-bound complex binding site; other site 40041004293 hinge residues; other site 40041004294 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 40041004295 HMMPfam hit to PF00497, Bacterial extracellular solute-binding protein, family 3, score 2.7e-69 40041004296 PS01039 Bacterial extracellular solute-binding proteins, family 3 signature. 40041004297 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 40041004298 dimer interface [polypeptide binding]; other site 40041004299 conserved gate region; other site 40041004300 putative PBP binding loops; other site 40041004301 ABC-ATPase subunit interface; other site 40041004302 HMMPfam hit to PF00528, Binding-protein-dependent transport systems inner membrane component, score 1.8e-29 40041004303 5 probable transmembrane helices predicted for SZO08180 by TMHMM2.0 at aa 20-42, 54-76, 80-102, 123-145 and 184-202 40041004304 PS00402 Binding-protein-dependent transport systems inner membrane comp. sign. 40041004305 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 40041004306 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 40041004307 Coenzyme A binding pocket [chemical binding]; other site 40041004308 HMMPfam hit to PF00583, GCN5-related N-acetyltransferase, score 2.3e-16 40041004309 Family 1 of Uracil-DNA glycosylase (UDG) enzymes; Region: UDG_F1; cd10027 40041004310 ligand binding site [chemical binding]; other site 40041004311 active site 40041004312 UGI interface [polypeptide binding]; other site 40041004313 catalytic site [active] 40041004314 HMMPfam hit to PF03167, Uracil-DNA glycosylase superfamily, score 3.2e-70 40041004315 PS00130 Uracil-DNA glycosylase signature. 40041004316 dihydroorotase; Validated; Region: pyrC; PRK09357 40041004317 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 40041004318 Dihydroorotase (DHOase), subgroup IIa; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This subgroup also contains proteins that lack the active site, like unc-33, a C; Region: DHOase_IIa; cd01317 40041004319 active site 40041004320 HMMPfam hit to PF01979, Amidohydrolase 1, score 3.7e-18 40041004321 PS00482 Dihydroorotase signature 1. 40041004322 PS00483 Dihydroorotase signature 2. 40041004323 putative glycerol-3-phosphate acyltransferase PlsY; Provisional; Region: PRK00220 40041004324 HMMPfam hit to PF02660, Protein of unknown function DUF205, score 3.1e-51 40041004325 6 probable transmembrane helices predicted for SZO08220 by TMHMM2.0 at aa 5-27, 42-61, 68-90, 105-127, 134-156 and 161-183 40041004326 DNA topoisomerase IV, B subunit, Gram-positive; Region: parE_Gpos; TIGR01058 40041004327 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 40041004328 Mg2+ binding site [ion binding]; other site 40041004329 G-X-G motif; other site 40041004330 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 40041004331 anchoring element; other site 40041004332 dimer interface [polypeptide binding]; other site 40041004333 ATP binding site [chemical binding]; other site 40041004334 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 40041004335 active site 40041004336 putative metal-binding site [ion binding]; other site 40041004337 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 40041004338 HMMPfam hit to PF02518, ATP-binding region, ATPase-like, score 3.3e-30 40041004339 HMMPfam hit to PF00204, DNA topoisomerase, type IIA, subunit B, region 2, score 4.9e-87 40041004340 HMMPfam hit to PF01751, TOPRIM, score 0.00021 40041004341 PS00177 DNA topoisomerase II signature. 40041004342 HMMPfam hit to PF00986, DNA topoisomerase, type IIA, subunit B, C-terminal, score 9.9e-44 40041004343 DNA topoisomerase IV, A subunit, Gram-positive; Region: parC_Gpos; TIGR01061 40041004344 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 40041004345 CAP-like domain; other site 40041004346 active site 40041004347 primary dimer interface [polypeptide binding]; other site 40041004348 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 40041004349 HMMPfam hit to PF00521, DNA topoisomerase, type IIA, subunit A or C-terminal, score 2e-288 40041004350 HMMPfam hit to PF03989, DNA gyrase/topoisomerase IV, subunit A, C-terminal beta-pinwheel, score 0.034 40041004351 HMMPfam hit to PF03989, DNA gyrase/topoisomerase IV, subunit A, C-terminal beta-pinwheel, score 0.00014 40041004352 HMMPfam hit to PF03989, DNA gyrase/topoisomerase IV, subunit A, C-terminal beta-pinwheel, score 2.1e-12 40041004353 HMMPfam hit to PF03989, DNA gyrase/topoisomerase IV, subunit A, C-terminal beta-pinwheel, score 0.052 40041004354 branched-chain amino acid aminotransferase; Provisional; Region: PRK13357 40041004355 BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557 40041004356 homodimer interface [polypeptide binding]; other site 40041004357 substrate-cofactor binding pocket; other site 40041004358 catalytic residue [active] 40041004359 HMMPfam hit to PF01063, Aminotransferase, class IV, score 4.7e-114 40041004360 PS00770 Aminotransferases class-IV signature. 40041004361 Protein of unknown function (DUF2969); Region: DUF2969; pfam11184 40041004362 30S ribosomal protein S1; Reviewed; Region: rpsA; PRK06676 40041004363 S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687 40041004364 RNA binding site [nucleotide binding]; other site 40041004365 S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465 40041004366 RNA binding site [nucleotide binding]; other site 40041004367 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 40041004368 RNA binding site [nucleotide binding]; other site 40041004369 S1_RPS1_repeat_hs4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_hs4; cd05692 40041004370 RNA binding site [nucleotide binding]; other site 40041004371 HMMPfam hit to PF00575, S1, RNA binding, score 0.004 40041004372 HMMPfam hit to PF00575, S1, RNA binding, score 3.6e-15 40041004373 HMMPfam hit to PF00575, S1, RNA binding, score 2.6e-27 40041004374 HMMPfam hit to PF00575, S1, RNA binding, score 3.1e-30 40041004375 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 40041004376 Transposase; Region: DDE_Tnp_ISL3; pfam01610 40041004377 HMMPfam hit to PF01610, Transposase, IS204/IS1001/IS1096/IS1165, score 1.4e-47 40041004378 Predicted helix-turn-helix motif with score 1838.000, SD 5.45 at aa 119-140, sequence VSMTAIADRLSISTSTVMRKLN 40041004379 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 40041004380 Transposase; Region: HTH_Tnp_1; cl17663 40041004381 HMMPfam hit to PF01527, Transposase IS3/IS911, score 0.00045 40041004382 putative transposase OrfB; Reviewed; Region: PHA02517 40041004383 HTH-like domain; Region: HTH_21; pfam13276 40041004384 Integrase core domain; Region: rve; pfam00665 40041004385 Integrase core domain; Region: rve_2; pfam13333 40041004386 HMMPfam hit to PF00665, Integrase, catalytic core, score 3e-39 40041004387 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 40041004388 non-specific DNA binding site [nucleotide binding]; other site 40041004389 salt bridge; other site 40041004390 sequence-specific DNA binding site [nucleotide binding]; other site 40041004391 transcriptional activator, Rgg/GadR/MutR family, C-terminal domain; Region: RGG_Cterm; TIGR01716 40041004392 H+ Antiporter protein; Region: 2A0121; TIGR00900 40041004393 11 probable transmembrane helices predicted for SZO08330 by TMHMM2.0 at aa 13-35, 45-64, 76-95, 99-116, 137-159, 169-188, 229-251, 264-286, 306-335, 360-382 and 387-404 40041004394 HMMPfam hit to PF07690, Major facilitator superfamily MFS-1, score 9.2e-12 40041004395 Domain of Unknown Function with PDB structure (DUF3862); Region: DUF3862; pfam12978 40041004396 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 40041004397 Transposase [DNA replication, recombination, and repair]; Region: COG5421 40041004398 Transposase [DNA replication, recombination, and repair]; Region: COG5421 40041004399 Bacterial capsule synthesis protein PGA_cap; Region: PGA_cap; smart00854 40041004400 CapA and related proteins, metallophosphatase domain; Region: MPP_CapA; cd07381 40041004401 putative active site [active] 40041004402 putative metal binding site [ion binding]; other site 40041004403 1 probable transmembrane helix predicted for SZO08360 by TMHMM2.0 at aa 12-34 40041004404 50S ribosomal protein L21; Validated; Region: rplU; PRK05573 40041004405 HMMPfam hit to PF00829, Ribosomal protein L21, score 5.2e-56 40041004406 PS01169 Ribosomal protein L21 signature. 40041004407 Protein of unknown function (DUF464); Region: DUF464; pfam04327 40041004408 HMMPfam hit to PF04327, Protein of unknown function DUF464, score 2.7e-30 40041004409 50S ribosomal protein L27; Validated; Region: rpmA; PRK05435 40041004410 HMMPfam hit to PF01016, Ribosomal protein L27, score 1.2e-47 40041004411 PS00831 Ribosomal protein L27 signature. 40041004412 Transcriptional regulator [Transcription]; Region: LysR; COG0583 40041004413 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 40041004414 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 40041004415 dimerization interface [polypeptide binding]; other site 40041004416 HMMPfam hit to PF00126, Bacterial regulatory protein, LysR, score 5.5e-18 40041004417 Predicted helix-turn-helix motif with score 1362.000, SD 3.83 at aa 16-37, sequence GTFREAASKLFVSQPSLSVSVK 40041004418 PS00044 Bacterial regulatory proteins, lysR family signature. 40041004419 HMMPfam hit to PF03466, LysR, substrate-binding, score 2.6e-12 40041004420 lipoprotein signal peptidase; Provisional; Region: PRK14797 40041004421 lipoprotein signal peptidase; Provisional; Region: PRK14787 40041004422 HMMPfam hit to PF01252, Peptidase A8, signal peptidase II, score 6.7e-44 40041004423 3 probable transmembrane helices predicted for SZO08410 by TMHMM2.0 at aa 61-79, 84-103 and 123-145 40041004424 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 40041004425 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 40041004426 RNA binding surface [nucleotide binding]; other site 40041004427 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 40041004428 active site 40041004429 HMMPfam hit to PF01479, RNA-binding S4, score 1.9e-09 40041004430 HMMPfam hit to PF00849, Pseudouridine synthase, score 1e-72 40041004431 PS01129 Rlu family of pseudouridine synthase signature. 40041004432 Uncharacterized conserved protein [Function unknown]; Region: COG0398 40041004433 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 40041004434 5 probable transmembrane helices predicted for SZO08430 by TMHMM2.0 at aa 13-32, 52-74, 81-103, 143-165 and 172-194 40041004435 HMMPfam hit to PF09335, SNARE associated Golgi protein, score 2.1e-24 40041004436 Pyrimidine operon attenuation protein/uracil phosphoribosyltransferase [Nucleotide transport and metabolism]; Region: PyrR; COG2065 40041004437 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 40041004438 active site 40041004439 HMMPfam hit to PF00156, Phosphoribosyltransferase, score 2.1e-16 40041004440 uracil transporter; Provisional; Region: PRK10720 40041004441 HMMPfam hit to PF00860, Xanthine/uracil/vitamin C permease, score 3e-105 40041004442 11 probable transmembrane helices predicted for SZO08450 by TMHMM2.0 at aa 26-48, 55-77, 87-109, 120-142, 152-174, 176-198, 237-259, 310-332, 342-364, 376-394 and 399-416 40041004443 PS01116 Xanthine/uracil permeases family signature. 40041004444 aspartate carbamoyltransferase catalytic subunit; Provisional; Region: pyrB; PRK00856 40041004445 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 40041004446 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 40041004447 HMMPfam hit to PF02729, Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding, score 1.9e-40 40041004448 PS00097 Aspartate and ornithine carbamoyltransferases signature. 40041004449 HMMPfam hit to PF00185, Aspartate/ornithine carbamoyltransferase, Asp/Orn-binding region, score 3.1e-32 40041004450 Predicted helix-turn-helix motif with score 1181.000, SD 3.21 at aa 236-257, sequence FSKEDYHRQFGLTEERYRRLKD 40041004451 carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564 40041004452 Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; smart01097 40041004453 Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744 40041004454 catalytic site [active] 40041004455 subunit interface [polypeptide binding]; other site 40041004456 HMMPfam hit to PF00988, Carbamoyl-phosphate synthase, small chain, score 3.6e-87 40041004457 HMMPfam hit to PF00117, Glutamine amidotransferase class-I, score 2.2e-63 40041004458 PS00442 Glutamine amidotransferases class-I active site. 40041004459 carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294 40041004460 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 40041004461 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 40041004462 Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787 40041004463 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 40041004464 ATP-grasp domain; Region: ATP-grasp_4; cl17255 40041004465 Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424 40041004466 IMP binding site; other site 40041004467 dimer interface [polypeptide binding]; other site 40041004468 interdomain contacts; other site 40041004469 partial ornithine binding site; other site 40041004470 HMMPfam hit to PF00289, Carbamoyl-phosphate synthetase large chain, N-terminal, score 3.5e-56 40041004471 HMMPfam hit to PF02786, Carbamoyl-phosphate synthase L chain, ATP-binding, score 1.6e-138 40041004472 PS00866 Carbamoyl-phosphate synthase subdomain signature 1. 40041004473 PS00867 Carbamoyl-phosphate synthase subdomain signature 2. 40041004474 HMMPfam hit to PF02787, Carbamoyl-phosphate synthetase large chain, oligomerisation, score 5.9e-58 40041004475 HMMPfam hit to PF00289, Carbamoyl-phosphate synthetase large chain, N-terminal, score 2.4e-28 40041004476 HMMPfam hit to PF02786, Carbamoyl-phosphate synthase L chain, ATP-binding, score 1.2e-31 40041004477 PS00866 Carbamoyl-phosphate synthase subdomain signature 1. 40041004478 PS00867 Carbamoyl-phosphate synthase subdomain signature 2. 40041004479 HMMPfam hit to PF02142, MGS-like, score 6.2e-24 40041004480 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 40041004481 HlyD family secretion protein; Region: HlyD_3; pfam13437 40041004482 1 probable transmembrane helix predicted for SZO08490 by TMHMM2.0 at aa 16-33 40041004483 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 40041004484 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 40041004485 Walker A/P-loop; other site 40041004486 ATP binding site [chemical binding]; other site 40041004487 Q-loop/lid; other site 40041004488 ABC transporter signature motif; other site 40041004489 Walker B; other site 40041004490 D-loop; other site 40041004491 H-loop/switch region; other site 40041004492 HMMPfam hit to PF00005, ABC transporter related, score 1.2e-60 40041004493 PS00017 ATP/GTP-binding site motif A (P-loop). 40041004494 PS00211 ABC transporters family signature. 40041004495 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 40041004496 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 40041004497 FtsX-like permease family; Region: FtsX; pfam02687 40041004498 4 probable transmembrane helices predicted for SZO08510 by TMHMM2.0 at aa 20-42, 284-306, 337-359 and 371-393 40041004499 HMMPfam hit to PF02687, Protein of unknown function DUF214, permase predicted, score 4.9e-45 40041004500 Uncharacterized conserved protein [Function unknown]; Region: COG0398 40041004501 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 40041004502 4 probable transmembrane helices predicted for SZO08520 by TMHMM2.0 at aa 15-34, 54-76, 86-108 and 172-194 40041004503 HMMPfam hit to PF09335, SNARE associated Golgi protein, score 2.8e-17 40041004504 30S ribosomal protein S16; Reviewed; Region: rpsP; PRK00040 40041004505 HMMPfam hit to PF00886, Ribosomal protein S16, score 1.9e-30 40041004506 Predicted RNA-binding protein (contains KH domain) [General function prediction only]; Region: COG1837 40041004507 KH domain; Region: KH_4; pfam13083 40041004508 G-X-X-G motif; other site 40041004509 HMMPfam hit to PF00013, K Homology, type 1, score 3.9e-05 40041004510 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 40041004511 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768 40041004512 catalytic residues [active] 40041004513 catalytic nucleophile [active] 40041004514 Presynaptic Site I dimer interface [polypeptide binding]; other site 40041004515 Synaptic Antiparallel dimer interface [polypeptide binding]; other site 40041004516 Synaptic Flat tetramer interface [polypeptide binding]; other site 40041004517 Synaptic Site I dimer interface [polypeptide binding]; other site 40041004518 DNA binding site [nucleotide binding] 40041004519 HMMPfam hit to PF00239, Resolvase, N-terminal, score 9.1e-44 40041004520 PS00397 Site-specific recombinases active site. 40041004521 Predicted helix-turn-helix motif with score 1890.000, SD 5.62 at aa 172-193, sequence ISLREGAKLLDVSHTTFSKWIQ 40041004522 Invertable sequence 40041004523 Listeria-Bacteroides repeat domain (List_Bact_rpt); Region: Flg_new; pfam09479 40041004524 Listeria-Bacteroides repeat domain (List_Bact_rpt); Region: Flg_new; cl09714 40041004525 Listeria-Bacteroides repeat domain (List_Bact_rpt); Region: Flg_new; cl09714 40041004526 PS00019 Actinin-type actin-binding domain signature 1. 40041004527 PS00343 Gram-positive cocci surface proteins 'anchoring' hexapeptide. 40041004528 1 probable transmembrane helix predicted for SZO08560 by TMHMM2.0 at aa 1124-1141 40041004529 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 40041004530 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 40041004531 Helix-turn-helix domain; Region: HTH_28; pfam13518 40041004532 Predicted helix-turn-helix motif with score 1140.000, SD 3.07 at aa 19-40, sequence KSIKCLSEKFSIAESDLKYMIR 40041004533 HMMPfam hit to PF01527, Transposase IS3/IS911, score 0.00062 40041004534 putative transposase OrfB; Reviewed; Region: PHA02517 40041004535 HTH-like domain; Region: HTH_21; pfam13276 40041004536 Integrase core domain; Region: rve; pfam00665 40041004537 Integrase core domain; Region: rve_2; pfam13333 40041004538 HMMPfam hit to PF00665, Integrase, catalytic core, score 7.9e-38 40041004539 16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK00122 40041004540 RimM N-terminal domain; Region: RimM; pfam01782 40041004541 PRC-barrel domain; Region: PRC; pfam05239 40041004542 HMMPfam hit to PF01782, RimM protein, score 7.5e-35 40041004543 HMMPfam hit to PF05239, PRC-barrel, score 7.6e-17 40041004544 tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026 40041004545 HMMPfam hit to PF01746, tRNA (guanine-N1-)-methyltransferase, score 6.8e-74 40041004546 Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492 40041004547 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 40041004548 HMMPfam hit to PF07992, FAD-dependent pyridine nucleotide-disulphide oxidoreductase, score 3.9e-13 40041004549 1 probable transmembrane helix predicted for SZO08610 by TMHMM2.0 at aa 9-31 40041004550 HMMPfam hit to PF00070, Pyridine nucleotide-disulphide oxidoreductase, NAD-binding region, score 6.5e-13 40041004551 Predicted membrane protein, putative toxin regulator [General function prediction only]; Region: PfoR; COG3641 40041004552 Phosphotransferase system, EIIC; Region: PTS_EIIC_2; pfam13303 40041004553 8 probable transmembrane helices predicted for SZO08620 by TMHMM2.0 at aa 16-38, 48-70, 109-131, 141-163, 184-206, 216-238, 266-288 and 308-330 40041004554 2-dehydropantoate 2-reductase; Reviewed; Region: PRK06522 40041004555 Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558 40041004556 Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546 40041004557 HMMPfam hit to PF02558, Ketopantoate reductase ApbA/PanE, N-terminal, score 4.8e-58 40041004558 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 40041004559 HMMPfam hit to PF08546, Ketopantoate reductase ApbA/PanE, C-terminal, score 9.2e-55 40041004560 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 40041004561 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 40041004562 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 40041004563 HMMPfam hit to PF08220, Bacterial regulatory protein, DeoR N-terminal, score 1.9e-14 40041004564 Predicted helix-turn-helix motif with score 985.000, SD 2.54 at aa 10-31, sequence VALEDLMQLLSSSESTVRRDLD 40041004565 HMMPfam hit to PF00455, Bacterial regulatory protein, DeoR, score 3.6e-41 40041004566 Fructose-1-phosphate kinase and related fructose-6-phosphate kinase (PfkB) [Carbohydrate transport and metabolism]; Region: FruK; COG1105 40041004567 1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164 40041004568 putative substrate binding site [chemical binding]; other site 40041004569 putative ATP binding site [chemical binding]; other site 40041004570 HMMPfam hit to PF00294, Carbohydrate/purine kinase, score 2.9e-54 40041004571 PS00583 pfkB family of carbohydrate kinases signature 1. 40041004572 PS00584 pfkB family of carbohydrate kinases signature 2. 40041004573 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 40041004574 active site 40041004575 phosphorylation site [posttranslational modification] 40041004576 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569 40041004577 active site 40041004578 P-loop; other site 40041004579 phosphorylation site [posttranslational modification] 40041004580 Phosphotransferase system, fructose-specific IIC component [Carbohydrate transport and metabolism]; Region: FruA; COG1299 40041004581 HMMPfam hit to PF00359, Phosphotransferase system, phosphoenolpyruvate-dependent sugar EIIA 2, score 2.3e-25 40041004582 HMMPfam hit to PF02379, Phosphotransferase system, fructose-specific IIB subunit, score 1.7e-51 40041004583 HMMPfam hit to PF02378, Phosphotransferase system, EIIC, score 1.6e-15 40041004584 10 probable transmembrane helices predicted for SZO08660 by TMHMM2.0 at aa 295-317, 338-360, 370-392, 399-421, 441-462, 474-496, 524-546, 558-580, 595-617 and 624-643 40041004585 PS00583 pfkB family of carbohydrate kinases signature 1. 40041004586 PS00044 Bacterial regulatory proteins, lysR family signature. 40041004587 Muramidase (flagellum-specific) [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FlgJ; COG1705 40041004588 1 probable transmembrane helix predicted for SZO08670 by TMHMM2.0 at aa 13-35 40041004589 HMMPfam hit to PF01832, Mannosyl-glycoprotein endo-beta-N-acetylglucosamidase, score 1.7e-27 40041004590 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 40041004591 non-specific DNA binding site [nucleotide binding]; other site 40041004592 salt bridge; other site 40041004593 sequence-specific DNA binding site [nucleotide binding]; other site 40041004594 HMMPfam hit to PF01381, Helix-turn-helix type 3, score 1.9e-17 40041004595 Predicted helix-turn-helix motif with score 1884.000, SD 5.60 at aa 14-35, sequence ITQEELASILEVSRQTIGSLEN 40041004596 4 probable transmembrane helices predicted for SZO08690 by TMHMM2.0 at aa 5-23, 38-60, 85-107 and 111-133 40041004597 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 40041004598 transmembrane helices; other site 40041004599 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 40041004600 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221 40041004601 HMMPfam hit to PF00939, Sodium/sulphate symporter, score 2.3e-06 40041004602 12 probable transmembrane helices predicted for SZO08700 by TMHMM2.0 at aa 12-29, 39-61, 74-96, 125-147, 168-187, 207-229, 257-274, 279-298, 311-333, 353-375, 395-417 and 427-449 40041004603 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 40041004604 Muramidase (flagellum-specific) [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FlgJ; COG1705 40041004605 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 40041004606 HMMPfam hit to PF01832, Mannosyl-glycoprotein endo-beta-N-acetylglucosamidase, score 1.7e-36 40041004607 Protein of unknown function (DUF1149); Region: DUF1149; pfam06619 40041004608 HMMPfam hit to PF06619, Protein of unknown function DUF1149, score 5.9e-95 40041004609 EDD domain protein, DegV family; Region: DegV; TIGR00762 40041004610 Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645 40041004611 HMMPfam hit to PF02645, DegV, score 1.5e-75 40041004612 tRNA CCA-pyrophosphorylase; Provisional; Region: PRK13299 40041004613 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 40041004614 active site 40041004615 NTP binding site [chemical binding]; other site 40041004616 metal binding triad [ion binding]; metal-binding site 40041004617 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 40041004618 tRNA nucleotidyltransferase domain 2 putative; Region: tRNA_NucTran2_2; pfam13735 40041004619 HMMPfam hit to PF01743, Polynucleotide adenylyltransferase region, score 8.4e-58 40041004620 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 40041004621 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 40041004622 Walker A/P-loop; other site 40041004623 ATP binding site [chemical binding]; other site 40041004624 Q-loop/lid; other site 40041004625 ABC transporter signature motif; other site 40041004626 Walker B; other site 40041004627 D-loop; other site 40041004628 H-loop/switch region; other site 40041004629 ABC transporter; Region: ABC_tran_2; pfam12848 40041004630 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 40041004631 HMMPfam hit to PF00005, ABC transporter related, score 6e-39 40041004632 PS00017 ATP/GTP-binding site motif A (P-loop). 40041004633 PS00211 ABC transporters family signature. 40041004634 HMMPfam hit to PF00005, ABC transporter related, score 1.9e-40 40041004635 PS00017 ATP/GTP-binding site motif A (P-loop). 40041004636 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 40041004637 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 40041004638 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 40041004639 Walker A/P-loop; other site 40041004640 ATP binding site [chemical binding]; other site 40041004641 Q-loop/lid; other site 40041004642 ABC transporter signature motif; other site 40041004643 Walker B; other site 40041004644 D-loop; other site 40041004645 H-loop/switch region; other site 40041004646 HMMPfam hit to PF00664, ABC transporter, transmembrane region, score 4e-31 40041004647 6 probable transmembrane helices predicted for SZO08760 by TMHMM2.0 at aa 20-37, 52-74, 129-151, 156-175, 237-259 and 274-296 40041004648 HMMPfam hit to PF00005, ABC transporter related, score 4.8e-52 40041004649 PS00017 ATP/GTP-binding site motif A (P-loop). 40041004650 PS00211 ABC transporters family signature. 40041004651 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 40041004652 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 40041004653 ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254 40041004654 Walker A/P-loop; other site 40041004655 ATP binding site [chemical binding]; other site 40041004656 Q-loop/lid; other site 40041004657 ABC transporter signature motif; other site 40041004658 Walker B; other site 40041004659 D-loop; other site 40041004660 H-loop/switch region; other site 40041004661 HMMPfam hit to PF00664, ABC transporter, transmembrane region, score 1.8e-37 40041004662 5 probable transmembrane helices predicted for SZO08770 by TMHMM2.0 at aa 21-43, 68-90, 152-169, 173-192 and 260-282 40041004663 HMMPfam hit to PF00005, ABC transporter related, score 1.4e-59 40041004664 PS00017 ATP/GTP-binding site motif A (P-loop). 40041004665 PS00211 ABC transporters family signature. 40041004666 glutamate dehydrogenase; Provisional; Region: PRK09414 40041004667 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 40041004668 NAD(P) binding domain of glutamate dehydrogenase, subgroup 2; Region: NAD_bind_2_Glu_DH; cd05313 40041004669 NAD(P) binding site [chemical binding]; other site 40041004670 HMMPfam hit to PF02812, Glu/Leu/Phe/Val dehydrogenase, dimerisation region, score 3.5e-86 40041004671 HMMPfam hit to PF00208, Glu/Leu/Phe/Val dehydrogenase, C-terminal, score 3.5e-132 40041004672 PS00017 ATP/GTP-binding site motif A (P-loop). 40041004673 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 40041004674 active site 40041004675 catalytic residues [active] 40041004676 metal binding site [ion binding]; metal-binding site 40041004677 HMMPfam hit to PF01327, Formylmethionine deformylase, score 3.6e-11 40041004678 5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737 40041004679 Bacillus subtilis YhcR endonuclease and related proteins, N-terminal metallophosphatase domain; Region: MPP_YhcR_N; cd07412 40041004680 putative active site [active] 40041004681 putative metal binding site [ion binding]; other site 40041004682 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 40041004683 HMMPfam hit to PF00746, Surface protein from Gram-positive cocci, anchor region, score 3.4e-05 40041004684 PS00343 Gram-positive cocci surface proteins 'anchoring' hexapeptide. 40041004685 HMMPfam hit to PF02872, 5'-Nucleotidase, C-terminal, score 9.2e-49 40041004686 HMMPfam hit to PF00149, Metallophosphoesterase, score 6.7e-10 40041004687 PS00786 5'-nucleotidase signature 2. 40041004688 1 probable transmembrane helix predicted for SZO08800 by TMHMM2.0 at aa 5-27 40041004689 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 40041004690 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 40041004691 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 40041004692 Walker A/P-loop; other site 40041004693 ATP binding site [chemical binding]; other site 40041004694 Q-loop/lid; other site 40041004695 ABC transporter signature motif; other site 40041004696 Walker B; other site 40041004697 D-loop; other site 40041004698 H-loop/switch region; other site 40041004699 6 probable transmembrane helices predicted for SZO08810 by TMHMM2.0 at aa 13-35, 55-77, 124-146, 151-173, 239-261 and 276-298 40041004700 HMMPfam hit to PF00664, ABC transporter, transmembrane region, score 3.8e-21 40041004701 HMMPfam hit to PF00005, ABC transporter related, score 5.3e-53 40041004702 PS00017 ATP/GTP-binding site motif A (P-loop). 40041004703 PS00211 ABC transporters family signature. 40041004704 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 40041004705 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 40041004706 ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254 40041004707 Walker A/P-loop; other site 40041004708 ATP binding site [chemical binding]; other site 40041004709 Q-loop/lid; other site 40041004710 ABC transporter signature motif; other site 40041004711 Walker B; other site 40041004712 D-loop; other site 40041004713 H-loop/switch region; other site 40041004714 3 probable transmembrane helices predicted for SZO08820 by TMHMM2.0 at aa 13-35, 64-83 and 151-173 40041004715 HMMPfam hit to PF00664, ABC transporter, transmembrane region, score 2.7e-18 40041004716 HMMPfam hit to PF00005, ABC transporter related, score 6.5e-55 40041004717 PS00017 ATP/GTP-binding site motif A (P-loop). 40041004718 PS00211 ABC transporters family signature. 40041004719 mevalonate kinase; Region: mevalon_kin; TIGR00549 40041004720 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 40041004721 HMMPfam hit to PF00288, GHMP kinase, score 1.4e-14 40041004722 HMMPfam hit to PF08544, GHMP kinase, C-terminal, score 1.5e-12 40041004723 diphosphomevalonate decarboxylase; Region: PLN02407 40041004724 diphosphomevalonate decarboxylase; Region: mevDPdecarb; TIGR01240 40041004725 HMMPfam hit to PF00288, GHMP kinase, score 1.5e-11 40041004726 PS00627 GHMP kinases ATP-binding domain. 40041004727 HMMPfam hit to PF08544, GHMP kinase, C-terminal, score 3.3e-09 40041004728 Mevalonate kinase [Lipid metabolism]; Region: ERG12; COG1577 40041004729 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 40041004730 HMMPfam hit to PF00288, GHMP kinase, score 2.7e-07 40041004731 HMMPfam hit to PF08544, GHMP kinase, C-terminal, score 5.6e-08 40041004732 isopentenyl pyrophosphate isomerase; Provisional; Region: PRK05437 40041004733 Isopentenyl-diphosphate:dimethylallyl diphosphate isomerase type 2 (IDI-2) FMN-binding domain. Two types of IDIs have been characterized at present. The long known IDI-1 is only dependent on divalent metals for activity, whereas IDI-2 requires a metal; Region: IDI-2_FMN; cd02811 40041004734 homotetramer interface [polypeptide binding]; other site 40041004735 FMN binding site [chemical binding]; other site 40041004736 homodimer contacts [polypeptide binding]; other site 40041004737 putative active site [active] 40041004738 putative substrate binding site [chemical binding]; other site 40041004739 HMMPfam hit to PF01645, Glutamate synthase, central-C, score 1.6e-06 40041004740 Class II hydroxymethylglutaryl-coenzyme A (HMG-CoA) reductase (HMGR); Region: HMG-CoA_reductase_classII; cd00644 40041004741 homodimer interface [polypeptide binding]; other site 40041004742 catalytic residues [active] 40041004743 NAD binding site [chemical binding]; other site 40041004744 substrate binding pocket [chemical binding]; other site 40041004745 flexible flap; other site 40041004746 "initiating" condensing enzymes are a subclass of decarboxylating condensing enzymes, including beta-ketoacyl [ACP] synthase, type III and polyketide synthases, type III, which include chalcone synthase and related enzymes. They are...; Region: init_cond_enzymes; cd00827 40041004747 3-hydroxy-3-methylglutaryl CoA synthase, prokaryotic clade; Region: HMG-CoA-S_prok; TIGR01835 40041004748 dimer interface [polypeptide binding]; other site 40041004749 active site 40041004750 HMMPfam hit to PF08540, Hydroxymethylglutaryl-coenzyme A synthase C-terminal, score 1.4e-11 40041004751 HMMPfam hit to PF01154, Hydroxymethylglutaryl-coenzyme A synthase, N-terminal, score 1.4e-07 40041004752 thymidylate synthase; Reviewed; Region: thyA; PRK01827 40041004753 Thymidylate synthase and pyrimidine hydroxymethylase: Thymidylate synthase (TS) and deoxycytidylate hydroxymethylase (dCMP-HMase) are homologs that catalyze analogous alkylation of C5 of pyrimidine nucleotides. Both enzymes are involved in the...; Region: TS_Pyrimidine_HMase; cd00351 40041004754 dimerization interface [polypeptide binding]; other site 40041004755 active site 40041004756 HMMPfam hit to PF00303, Thymidylate synthase, C-terminal, score 8.5e-106 40041004757 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 40041004758 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cd00209 40041004759 folate binding site [chemical binding]; other site 40041004760 NADP+ binding site [chemical binding]; other site 40041004761 HMMPfam hit to PF00186, Dihydrofolate reductase region, score 1.2e-26 40041004762 PS00075 Dihydrofolate reductase signature. 40041004763 2 probable transmembrane helices predicted for SZO08910 by TMHMM2.0 at aa 5-24 and 31-53 40041004764 ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342 40041004765 ClpX C4-type zinc finger; Region: zf-C4_ClpX; pfam06689 40041004766 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 40041004767 Walker A motif; other site 40041004768 ATP binding site [chemical binding]; other site 40041004769 Walker B motif; other site 40041004770 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 40041004771 HMMPfam hit to PF06689, Zinc finger, C4-type, score 1.2e-23 40041004772 HMMPfam hit to PF07724, ATPase AAA-2, score 4e-81 40041004773 PS00017 ATP/GTP-binding site motif A (P-loop). 40041004774 YihA (EngB) GTPase family; Region: YihA_EngB; cd01876 40041004775 G1 box; other site 40041004776 GTP/Mg2+ binding site [chemical binding]; other site 40041004777 Switch I region; other site 40041004778 G2 box; other site 40041004779 G3 box; other site 40041004780 Switch II region; other site 40041004781 G4 box; other site 40041004782 G5 box; other site 40041004783 HMMPfam hit to PF01926, GTP-binding protein, HSR1-related, score 6.8e-36 40041004784 PS00017 ATP/GTP-binding site motif A (P-loop). 40041004785 Leucine rich repeats (6 copies); Region: LRR_5; pfam13306 40041004786 Leucine rich repeats (6 copies); Region: LRR_5; pfam13306 40041004787 Leucine rich repeats (6 copies); Region: LRR_5; pfam13306 40041004788 PS00343 Gram-positive cocci surface proteins 'anchoring' hexapeptide. 40041004789 1 probable transmembrane helix predicted for SZO08940 by TMHMM2.0 at aa 974-991 40041004790 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 40041004791 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 40041004792 Walker A motif; other site 40041004793 ATP binding site [chemical binding]; other site 40041004794 Walker B motif; other site 40041004795 arginine finger; other site 40041004796 UvrB/uvrC motif; Region: UVR; pfam02151 40041004797 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 40041004798 Walker A motif; other site 40041004799 ATP binding site [chemical binding]; other site 40041004800 Walker B motif; other site 40041004801 arginine finger; other site 40041004802 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 40041004803 HMMPfam hit to PF07724, ATPase AAA-2, score 2e-76 40041004804 PS00017 ATP/GTP-binding site motif A (P-loop). 40041004805 HMMPfam hit to PF00004, AAA ATPase, core, score 8.2e-17 40041004806 PS00017 ATP/GTP-binding site motif A (P-loop). 40041004807 Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413 40041004808 active site 40041004809 multimer interface [polypeptide binding]; other site 40041004810 HMMPfam hit to PF00334, Nucleoside diphosphate kinase, core, score 3.5e-58 40041004811 DNA/RNA non-specific endonuclease; Region: Endonuclea_NS_2; cl17626 40041004812 DNA/RNA non-specific endonuclease; Region: Endonuclease_NS; smart00892 40041004813 HMMPfam hit to PF01223, DNA/RNA non-specific endonuclease, score 1.5e-27 40041004814 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 40041004815 Putative catalytic NodB homology domain of PgaB, IcaB, and similar proteins which consist of a deformed (beta/alpha)8 barrel fold with 5- or 6-strands; Region: CE4_NodB_like_5s_6s; cd10918 40041004816 putative active site [active] 40041004817 putative metal binding site [ion binding]; other site 40041004818 HMMPfam hit to PF01522, Polysaccharide deacetylase, score 1.5e-38 40041004819 1 probable transmembrane helix predicted for SZO08980 by TMHMM2.0 at aa 13-35 40041004820 homoserine dehydrogenase; Provisional; Region: PRK06349 40041004821 Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447 40041004822 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 40041004823 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 40041004824 HMMPfam hit to PF03447, Aspartate/homoserine dehydrogenase, NAD-binding, score 1.2e-24 40041004825 HMMPfam hit to PF00742, Homoserine dehydrogenase, catalytic, score 1.2e-80 40041004826 PS01042 Homoserine dehydrogenase signature. 40041004827 homoserine kinase; Provisional; Region: PRK01212 40041004828 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 40041004829 HMMPfam hit to PF00288, GHMP kinase, score 2.2e-19 40041004830 PS00627 GHMP kinases ATP-binding domain. 40041004831 HMMPfam hit to PF08544, GHMP kinase, C-terminal, score 3.7e-09 40041004832 folylpolyglutamate synthase/dihydrofolate synthase; Region: folC; TIGR01499 40041004833 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 40041004834 HMMPfam hit to PF02875, Mur ligase, C-terminal, score 0.013 40041004835 GTP cyclohydrolase I (GTP-CH-I) catalyzes the conversion of GTP into dihydroneopterin triphosphate. The enzyme product is the precursor of tetrahydrofolate in eubacteria, fungi, and plants and of the folate analogs in methanogenic bacteria. In...; Region: GTP_cyclohydro1; cd00642 40041004836 homodecamer interface [polypeptide binding]; other site 40041004837 GTP cyclohydrolase I; Provisional; Region: PLN03044 40041004838 active site 40041004839 putative catalytic site residues [active] 40041004840 zinc binding site [ion binding]; other site 40041004841 GTP-CH-I/GFRP interaction surface; other site 40041004842 HMMPfam hit to PF01227, GTP cyclohydrolase I, score 8.5e-54 40041004843 PS00859 GTP cyclohydrolase I signature 1. 40041004844 PS00860 GTP cyclohydrolase I signature 2. 40041004845 DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739 40041004846 dihydropteroate synthase; Region: DHPS; TIGR01496 40041004847 substrate binding pocket [chemical binding]; other site 40041004848 dimer interface [polypeptide binding]; other site 40041004849 inhibitor binding site; inhibition site 40041004850 PS00792 Dihydropteroate synthase signature 1. 40041004851 HMMPfam hit to PF00809, Dihydropteroate synthase, DHPS, score 2.7e-104 40041004852 PS00793 Dihydropteroate synthase signature 2. 40041004853 Dihydroneopterin aldolase (DHNA) and 7,8-dihydroneopterin triphosphate epimerase domain (DHNTPE); these enzymes have been designated folB and folX, respectively. Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and...; Region: DHNA_DHNTPE; cd00534 40041004854 homooctamer interface [polypeptide binding]; other site 40041004855 active site 40041004856 HMMPfam hit to PF02152, Dihydroneopterin aldolase, score 9.9e-44 40041004857 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483 40041004858 catalytic center binding site [active] 40041004859 ATP binding site [chemical binding]; other site 40041004860 HMMPfam hit to PF01288, 7,8-Dihydro-6-hydroxymethylpterin-pyrophosphokinase, HPPK, score 1.3e-68 40041004861 PS00794 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase signature. 40041004862 UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK13905 40041004863 FAD binding domain; Region: FAD_binding_4; pfam01565 40041004864 UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873 40041004865 HMMPfam hit to PF01565, FAD linked oxidase, N-terminal, score 1.6e-34 40041004866 HMMPfam hit to PF02873, UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal, score 7.7e-37 40041004867 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 40041004868 ATP-binding cassette domain of the polyamine transporter; Region: ABC_PotA_N; cd03300 40041004869 Walker A/P-loop; other site 40041004870 ATP binding site [chemical binding]; other site 40041004871 Q-loop/lid; other site 40041004872 ABC transporter signature motif; other site 40041004873 Walker B; other site 40041004874 D-loop; other site 40041004875 H-loop/switch region; other site 40041004876 TOBE domain; Region: TOBE_2; pfam08402 40041004877 HMMPfam hit to PF00005, ABC transporter related, score 8.8e-65 40041004878 PS00017 ATP/GTP-binding site motif A (P-loop). 40041004879 PS00211 ABC transporters family signature. 40041004880 HMMPfam hit to PF08402, Transport-associated OB, type 2, score 4.9e-08 40041004881 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 40041004882 dimer interface [polypeptide binding]; other site 40041004883 conserved gate region; other site 40041004884 putative PBP binding loops; other site 40041004885 ABC-ATPase subunit interface; other site 40041004886 6 probable transmembrane helices predicted for SZO09080 by TMHMM2.0 at aa 7-29, 61-83, 90-112, 139-161, 202-224 and 239-258 40041004887 HMMPfam hit to PF00528, Binding-protein-dependent transport systems inner membrane component, score 0.0056 40041004888 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 40041004889 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 40041004890 dimer interface [polypeptide binding]; other site 40041004891 conserved gate region; other site 40041004892 putative PBP binding loops; other site 40041004893 ABC-ATPase subunit interface; other site 40041004894 7 probable transmembrane helices predicted for SZO09090 by TMHMM2.0 at aa 7-29, 62-84, 97-119, 124-146, 174-193, 198-217 and 230-249 40041004895 HMMPfam hit to PF00528, Binding-protein-dependent transport systems inner membrane component, score 4.5e-11 40041004896 Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687 40041004897 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 40041004898 1 probable transmembrane helix predicted for SZO09100 by TMHMM2.0 at aa 5-24 40041004899 HMMPfam hit to PF01547, Bacterial extracellular solute-binding protein, family 1, score 6.8e-15 40041004900 PS00017 ATP/GTP-binding site motif A (P-loop). 40041004901 ClC chloride channel EriC. This domain is found in the EriC chloride transporters that mediate the extreme acid resistance response in eubacteria and archaea. This response allows bacteria to survive in the acidic environments by decarboxylation-linked...; Region: EriC; cd01031 40041004902 Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038 40041004903 Cl- selectivity filter; other site 40041004904 Cl- binding residues [ion binding]; other site 40041004905 pore gating glutamate residue; other site 40041004906 dimer interface [polypeptide binding]; other site 40041004907 H+/Cl- coupling transport residue; other site 40041004908 10 probable transmembrane helices predicted for SZO09110 by TMHMM2.0 at aa 17-39, 59-78, 156-178, 191-213, 226-248, 268-288, 309-331, 335-354, 367-389 and 402-424 40041004909 HMMPfam hit to PF00654, Chloride channel, core, score 9.5e-45 40041004910 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 40041004911 HMMPfam hit to PF02080, TrkA-C, score 5.8e-06 40041004912 NnaC (CMP-NeuNAc synthetase) _like subfamily of SGNH_hydrolases, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its...; Region: NnaC_like; cd01841 40041004913 active site 40041004914 catalytic triad [active] 40041004915 oxyanion hole [active] 40041004916 HMMPfam hit to PF00657, Lipolytic enzyme, G-D-S-L, score 1.7e-07 40041004917 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 40041004918 Domain of unknown function DUF20; Region: UPF0118; pfam01594 40041004919 8 probable transmembrane helices predicted for SZO09130 by TMHMM2.0 at aa 17-34, 49-68, 88-110, 180-202, 248-270, 274-296, 305-327 and 342-364 40041004920 HMMPfam hit to PF01594, Protein of unknown function UPF0118, score 5.1e-23 40041004921 hypothetical protein; Reviewed; Region: PRK00024 40041004922 Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071 40041004923 MPN+ (JAMM) motif; other site 40041004924 Zinc-binding site [ion binding]; other site 40041004925 HMMPfam hit to PF04002, DNA repair protein RadC, score 4.5e-68 40041004926 PS01302 DNA repair protein radC family signature. 40041004927 Predicted glutamine amidotransferases [General function prediction only]; Region: COG2071 40041004928 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_2; cd01745 40041004929 catalytic triad [active] 40041004930 HMMPfam hit to PF07722, Peptidase C26, score 8.3e-101 40041004931 AT-rich DNA-binding protein [General function prediction only]; Region: COG2344 40041004932 Putative DNA-binding protein N-terminus; Region: Put_DNA-bind_N; pfam06971 40041004933 CoA binding domain; Region: CoA_binding; pfam02629 40041004934 HMMPfam hit to PF02629, CoA-binding, score 3.7e-33 40041004935 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 40041004936 HMMPfam hit to PF06971, Rex DNA-binding, C-terminal, score 8.3e-28 40041004937 Predicted helix-turn-helix motif with score 1210.000, SD 3.31 at aa 33-54, sequence ASSKQIADAMGIDSATVRRDFS 40041004938 Putative amino acid metabolism; Region: DUF1831; pfam08866 40041004939 HMMPfam hit to PF08866, Protein of unknown function DUF1831, score 1.3e-80 40041004940 Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104 40041004941 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 40041004942 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 40041004943 catalytic residue [active] 40041004944 HMMPfam hit to PF00266, Aminotransferase, class V, score 1.4e-90 40041004945 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 40041004946 PS00595 Aminotransferases class-V pyridoxal-phosphate attachment site. 40041004947 ribose-phosphate pyrophosphokinase; Provisional; Region: PRK02458 40041004948 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 40041004949 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 40041004950 active site 40041004951 HMMPfam hit to PF00156, Phosphoribosyltransferase, score 9.9e-20 40041004952 Uncharacterized subgroup 1 of the CYTH-like superfamily; Region: CYTH-like_Pase_1; cd07762 40041004953 putative active site [active] 40041004954 putative metal binding residues [ion binding]; other site 40041004955 signature motif; other site 40041004956 putative triphosphate binding site [ion binding]; other site 40041004957 HMMPfam hit to PF01928, Adenylate cyclase, score 5.8e-39 40041004958 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 40041004959 synthetase active site [active] 40041004960 NTP binding site [chemical binding]; other site 40041004961 metal binding site [ion binding]; metal-binding site 40041004962 HMMPfam hit to PF04607, RelA/SpoT, score 9.8e-49 40041004963 inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK04885 40041004964 ATP-NAD kinase; Region: NAD_kinase; pfam01513 40041004965 HMMPfam hit to PF01513, ATP-NAD/AcoX kinase, score 2e-40 40041004966 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 40041004967 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 40041004968 active site 40041004969 HMMPfam hit to PF00849, Pseudouridine synthase, score 1.4e-50 40041004970 PS01129 Rlu family of pseudouridine synthase signature. 40041004971 phosphotransacetylase; Reviewed; Region: eutD; PRK09653 40041004972 HMMPfam hit to PF01515, Phosphate acetyl/butaryl transferase, score 1.6e-164 40041004973 classical (c) SDR, subgroup 5; Region: SDR_c5; cd05346 40041004974 malonic semialdehyde reductase; Provisional; Region: PRK10538 40041004975 putative NAD(P) binding site [chemical binding]; other site 40041004976 homotetramer interface [polypeptide binding]; other site 40041004977 homodimer interface [polypeptide binding]; other site 40041004978 active site 40041004979 HMMPfam hit to PF00106, Short-chain dehydrogenase/reductase SDR, score 8.5e-29 40041004980 PS00061 Short-chain dehydrogenases/reductases family signature. 40041004981 PAS domain; Region: PAS_10; pfam13596 40041004982 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 40041004983 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 40041004984 Walker A/P-loop; other site 40041004985 ATP binding site [chemical binding]; other site 40041004986 Q-loop/lid; other site 40041004987 ABC transporter signature motif; other site 40041004988 Walker B; other site 40041004989 D-loop; other site 40041004990 H-loop/switch region; other site 40041004991 HMMPfam hit to PF00005, ABC transporter related, score 9.3e-60 40041004992 PS00017 ATP/GTP-binding site motif A (P-loop). 40041004993 PS00211 ABC transporters family signature. 40041004994 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 40041004995 dimer interface [polypeptide binding]; other site 40041004996 conserved gate region; other site 40041004997 putative PBP binding loops; other site 40041004998 ABC-ATPase subunit interface; other site 40041004999 Periplasmic glycine betaine/choline-binding (lipo)protein of an ABC-type transport system (osmoprotectant binding protein) [Cell envelope biogenesis, outer membrane]; Region: OpuBC; COG1732 40041005000 ABC-type proline/glycine betaine transport systems, periplasmic components [Amino acid transport and metabolism]; Region: ProX; cl17891 40041005001 HMMPfam hit to PF00528, Binding-protein-dependent transport systems inner membrane component, score 6.6e-24 40041005002 6 probable transmembrane helices predicted for SZO09280 by TMHMM2.0 at aa 23-45, 52-74, 78-97, 147-169, 179-198 and 210-229 40041005003 PS00402 Binding-protein-dependent transport systems inner membrane comp. sign. 40041005004 HMMPfam hit to PF04069, Substrate-binding region of ABC-type glycine betaine transport system, score 4.9e-83 40041005005 guanosine 5'-monophosphate oxidoreductase; Provisional; Region: PRK05458 40041005006 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 40041005007 active site 40041005008 HMMPfam hit to PF00478, IMP dehydrogenase/GMP reductase, score 8.4e-148 40041005009 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 40041005010 active site 40041005011 HMMPfam hit to PF00156, Phosphoribosyltransferase, score 7.1e-17 40041005012 Membrane-associated lipoprotein involved in thiamine biosynthesis [Coenzyme metabolism]; Region: ApbE; COG1477 40041005013 ApbE family; Region: ApbE; pfam02424 40041005014 HMMPfam hit to PF02424, ApbE-like lipoprotein, score 1.9e-28 40041005015 4-oxalocrotonate tautomerase; Provisional; Region: PRK02289 40041005016 active site 1 [active] 40041005017 dimer interface [polypeptide binding]; other site 40041005018 hexamer interface [polypeptide binding]; other site 40041005019 active site 2 [active] 40041005020 HMMPfam hit to PF01361, 4-oxalocrotonate tautomerase, score 3.6e-29 40041005021 thymidine kinase; Provisional; Region: PRK04296 40041005022 HMMPfam hit to PF00265, Thymidine kinase, score 1.7e-67 40041005023 PS00017 ATP/GTP-binding site motif A (P-loop). 40041005024 PS00603 Thymidine kinase cellular-type signature. 40041005025 peptide chain release factor 1; Validated; Region: prfA; PRK00591 40041005026 This domain is found in peptide chain release factors; Region: PCRF; smart00937 40041005027 RF-1 domain; Region: RF-1; pfam00472 40041005028 HMMPfam hit to PF03462, PCRF, score 7.5e-65 40041005029 HMMPfam hit to PF00472, Class I peptide chain release factor, score 7.5e-60 40041005030 N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328 40041005031 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 40041005032 S-adenosylmethionine binding site [chemical binding]; other site 40041005033 HMMPfam hit to PF08242, Methyltransferase type 12, score 6.7e-06 40041005034 PS00092 N-6 Adenine-specific DNA methylases signature. 40041005035 Putative translation factor (SUA5) [Translation, ribosomal structure and biogenesis]; Region: SUA5; COG0009 40041005036 HMMPfam hit to PF01300, SUA5/yciO/yrdC, N-terminal, score 7.8e-38 40041005037 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 40041005038 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 40041005039 Coenzyme A binding pocket [chemical binding]; other site 40041005040 HMMPfam hit to PF00583, GCN5-related N-acetyltransferase, score 2.6e-14 40041005041 serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011 40041005042 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378 40041005043 dimer interface [polypeptide binding]; other site 40041005044 active site 40041005045 glycine-pyridoxal phosphate binding site [chemical binding]; other site 40041005046 folate binding site [chemical binding]; other site 40041005047 HMMPfam hit to PF00464, Glycine hydroxymethyltransferase, score 1.3e-231 40041005048 PS00096 Serine hydroxymethyltransferase pyridoxal-phosphate attachment site. 40041005049 37-kD nucleoid-associated bacterial protein; Region: NA37; cl15473 40041005050 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 40041005051 N-acetyl-D-glucosamine binding site [chemical binding]; other site 40041005052 catalytic residue [active] 40041005053 coenzyme A disulfide reductase; Reviewed; Region: PRK09564 40041005054 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 40041005055 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 40041005056 HMMPfam hit to PF07992, FAD-dependent pyridine nucleotide-disulphide oxidoreductase, score 4e-45 40041005057 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 40041005058 HMMPfam hit to PF00070, Pyridine nucleotide-disulphide oxidoreductase, NAD-binding region, score 2.4e-33 40041005059 HMMPfam hit to PF02852, Pyridine nucleotide-disulphide oxidoreductase dimerisation region, score 3.3e-07 40041005060 L-lactate dehydrogenase; Reviewed; Region: ldh; PRK00066 40041005061 L-2-hydroxyisocapronate dehydrogenases and some bacterial L-lactate dehydrogenases; Region: HicDH_like; cd05291 40041005062 tetramer (dimer of dimers) interface [polypeptide binding]; other site 40041005063 NAD binding site [chemical binding]; other site 40041005064 dimer interface [polypeptide binding]; other site 40041005065 substrate binding site [chemical binding]; other site 40041005066 HMMPfam hit to PF02866, Lactate/malate dehydrogenase, score 4.5e-78 40041005067 PS00064 L-lactate dehydrogenase active site. 40041005068 HMMPfam hit to PF00056, Lactate/malate dehydrogenase, score 3.2e-78 40041005069 DNA gyrase subunit A; Validated; Region: PRK05560 40041005070 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 40041005071 CAP-like domain; other site 40041005072 active site 40041005073 primary dimer interface [polypeptide binding]; other site 40041005074 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 40041005075 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 40041005076 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 40041005077 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 40041005078 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 40041005079 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 40041005080 HMMPfam hit to PF00521, DNA topoisomerase, type IIA, subunit A or C-terminal, score 0 40041005081 HMMPfam hit to PF03989, DNA gyrase/topoisomerase IV, subunit A, C-terminal beta-pinwheel, score 1.5e-13 40041005082 HMMPfam hit to PF03989, DNA gyrase/topoisomerase IV, subunit A, C-terminal beta-pinwheel, score 2.8e-17 40041005083 HMMPfam hit to PF03989, DNA gyrase/topoisomerase IV, subunit A, C-terminal beta-pinwheel, score 5.9e-14 40041005084 HMMPfam hit to PF03989, DNA gyrase/topoisomerase IV, subunit A, C-terminal beta-pinwheel, score 1.8e-13 40041005085 HMMPfam hit to PF03989, DNA gyrase/topoisomerase IV, subunit A, C-terminal beta-pinwheel, score 7.5e-15 40041005086 HMMPfam hit to PF03989, DNA gyrase/topoisomerase IV, subunit A, C-terminal beta-pinwheel, score 4.5e-12 40041005087 Sortase A (SrtA) or subfamily-1 sortases are cysteine transpeptidases found in gram-positive bacteria that anchor surface proteins to peptidoglycans of the bacterial cell wall envelope. They do so by catalyzing a transpeptidation reaction in which the...; Region: Sortase_A_1; cd06165 40041005088 active site 40041005089 catalytic site [active] 40041005090 1 probable transmembrane helix predicted for SZO09440 by TMHMM2.0 at aa 4-21 40041005091 HMMPfam hit to PF04203, Peptidase C60, sortase A and B, score 5.9e-55 40041005092 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_1; cd08352 40041005093 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 40041005094 putative metal binding site [ion binding]; other site 40041005095 HMMPfam hit to PF00903, Glyoxalase/bleomycin resistance protein/dioxygenase, score 1.6e-18 40041005096 PS00934 Glyoxalase I signature 1. 40041005097 Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297 40041005098 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 40041005099 intersubunit interface [polypeptide binding]; other site 40041005100 HMMPfam hit to PF01297, Periplasmic solute binding protein, score 1.8e-76 40041005101 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 40041005102 streptococcal histidine triad protein; Region: strep_his_triad; TIGR01363 40041005103 Predicted secreted protein [Function unknown]; Region: COG4086 40041005104 Protein of unknown function (DUF1002); Region: DUF1002; pfam06207 40041005105 1 probable transmembrane helix predicted for SZO09490 by TMHMM2.0 at aa 7-29 40041005106 HMMPfam hit to PF06207, Protein of unknown function DUF1002, score 5.6e-97 40041005107 FemAB family; Region: FemAB; pfam02388 40041005108 HMMPfam hit to PF02388, Methicillin resistance protein, score 3.6e-19 40041005109 signal recognition particle protein; Provisional; Region: PRK10867 40041005110 SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963 40041005111 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 40041005112 P loop; other site 40041005113 GTP binding site [chemical binding]; other site 40041005114 Signal peptide binding domain; Region: SRP_SPB; pfam02978 40041005115 HMMPfam hit to PF02978, Signal recognition particle, SRP54 subunit, M-domain, score 8.1e-55 40041005116 HMMPfam hit to PF00448, Signal recognition particle, SRP54 subunit, GTPase, score 3.3e-118 40041005117 PS00300 SRP54-type proteins GTP-binding domain signature. 40041005118 PS00017 ATP/GTP-binding site motif A (P-loop). 40041005119 HMMPfam hit to PF02881, Signal recognition particle, SRP54 subunit, helical bundle, score 1.8e-31 40041005120 Putative helix-turn-helix protein, YlxM / p13 like; Region: UPF0122; pfam04297 40041005121 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 40041005122 HMMPfam hit to PF04297, helix-turn-helix protein, YlxM/p13-like, score 3.5e-60 40041005123 Predicted helix-turn-helix motif with score 1959.000, SD 5.86 at aa 36-57, sequence YSLAEIAEEFGVSRQAVYDNIK 40041005124 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 40041005125 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 40041005126 DNA-binding site [nucleotide binding]; DNA binding site 40041005127 UTRA domain; Region: UTRA; pfam07702 40041005128 HMMPfam hit to PF07702, UbiC transcription regulator-associated, score 1.2e-46 40041005129 Predicted helix-turn-helix motif with score 1149.000, SD 3.10 at aa 161-182, sequence QTLTSNGYEIGKSQQTIYAKIA 40041005130 HMMPfam hit to PF00392, Bacterial regulatory protein GntR, HTH, score 3.6e-25 40041005131 PS00043 Bacterial regulatory proteins, gntR family signature. 40041005132 Predicted helix-turn-helix motif with score 1494.000, SD 4.28 at aa 28-49, sequence PSERDLAEHFEVSRMTLRQAIT 40041005133 GMP synthase; Reviewed; Region: guaA; PRK00074 40041005134 Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742 40041005135 AMP/PPi binding site [chemical binding]; other site 40041005136 candidate oxyanion hole; other site 40041005137 catalytic triad [active] 40041005138 potential glutamine specificity residues [chemical binding]; other site 40041005139 The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997 40041005140 ATP Binding subdomain [chemical binding]; other site 40041005141 Dimerization subdomain; other site 40041005142 HMMPfam hit to PF00117, Glutamine amidotransferase class-I, score 2.2e-56 40041005143 PS00442 Glutamine amidotransferases class-I active site. 40041005144 HMMPfam hit to PF02540, NAD+ synthase, score 2.4e-05 40041005145 HMMPfam hit to PF00958, GMP synthase, C-terminal, score 4.7e-55 40041005146 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 40041005147 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 40041005148 non-specific DNA binding site [nucleotide binding]; other site 40041005149 salt bridge; other site 40041005150 sequence-specific DNA binding site [nucleotide binding]; other site 40041005151 Predicted transcriptional regulator [Transcription]; Region: COG2932 40041005152 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 40041005153 Catalytic site [active] 40041005154 HMMPfam hit to PF00717, Peptidase S24, S26A and S26B, C-terminal, score 6.1e-18 40041005155 HMMPfam hit to PF01381, Helix-turn-helix type 3, score 1.7e-13 40041005156 Predicted helix-turn-helix motif with score 2520.000, SD 7.77 at aa 18-39, sequence ISQEQLGELLGVNKMTISNWEK 40041005157 Predicted membrane protein [Function unknown]; Region: COG2246 40041005158 GtrA-like protein; Region: GtrA; pfam04138 40041005159 4 probable transmembrane helices predicted for SZO09560 by TMHMM2.0 at aa 7-29, 34-56, 77-96 and 120-139 40041005160 HMMPfam hit to PF04138, GtrA-like protein, score 3.1e-13 40041005161 genomic island 40041005162 Catalytic domain of Protein Kinases; Region: PKc; cd00180 40041005163 active site 40041005164 ATP binding site [chemical binding]; other site 40041005165 substrate binding site [chemical binding]; other site 40041005166 activation loop (A-loop); other site 40041005167 HMMPfam hit to PF00069, Protein kinase, core, score 2.8e-17 40041005168 PS00109 Tyrosine protein kinases specific active-site signature. 40041005169 Protein of unknown function (DUF4065); Region: DUF4065; pfam13274 40041005170 Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; pfam04313 40041005171 N-6 DNA Methylase; Region: N6_Mtase; pfam02384 40041005172 Eco57I restriction-modification methylase; Region: Eco57I; pfam07669 40041005173 HMMPfam hit to PF04313, Restriction endonuclease, type I, EcoRI, R subunit/Type III, Res subunit, N terminus, score 9.5e-15 40041005174 HMMPfam hit to PF07669, Restriction endonuclease, Eco57I, score 0.00019 40041005175 PS00092 N-6 Adenine-specific DNA methylases signature. 40041005176 Methyltransferase domain; Region: Methyltransf_26; pfam13659 40041005177 HMMPfam hit to PF02384, N-6 DNA methylase, score 4.7e-05 40041005178 PS00092 N-6 Adenine-specific DNA methylases signature. 40041005179 Domain of unknown function (DUF4379); Region: DUF4379; pfam14311 40041005180 Domain of unknown function (DUF4379); Region: DUF4379; pfam14311 40041005181 Domain of unknown function (DUF4379); Region: DUF4379; pfam14311 40041005182 Domain of unknown function (DUF4379); Region: DUF4379; pfam14311 40041005183 PS00190 Cytochrome c family heme-binding site signature. 40041005184 PS00190 Cytochrome c family heme-binding site signature. 40041005185 PS00190 Cytochrome c family heme-binding site signature. 40041005186 site-specific tyrosine recombinase XerS; Reviewed; Region: xerS; PRK05084 40041005187 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 40041005188 active site 40041005189 DNA binding site [nucleotide binding] 40041005190 Int/Topo IB signature motif; other site 40041005191 HMMPfam hit to PF02899, Integrase, N-terminal SAM-like, phage, score 9.9e-08 40041005192 HMMPfam hit to PF00589, Integrase, catalytic core, phage, score 1.8e-15 40041005193 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 40041005194 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 40041005195 ATP binding site [chemical binding]; other site 40041005196 Mg2+ binding site [ion binding]; other site 40041005197 G-X-G motif; other site 40041005198 HMMPfam hit to PF02518, ATP-binding region, ATPase-like, score 1.7e-26 40041005199 2 probable transmembrane helices predicted for SZO09670 by TMHMM2.0 at aa 12-30 and 40-57 40041005200 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 40041005201 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 40041005202 active site 40041005203 phosphorylation site [posttranslational modification] 40041005204 intermolecular recognition site; other site 40041005205 dimerization interface [polypeptide binding]; other site 40041005206 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 40041005207 DNA binding site [nucleotide binding] 40041005208 HMMPfam hit to PF00486, Transcriptional regulatory protein, C-terminal, score 3e-21 40041005209 PS00339 Aminoacyl-transfer RNA synthetases class-II signature 2. 40041005210 HMMPfam hit to PF00072, Response regulator receiver, score 7e-23 40041005211 FtsX-like permease family; Region: FtsX; pfam02687 40041005212 10 probable transmembrane helices predicted for SZO09690 by TMHMM2.0 at aa 21-43, 53-75, 105-127, 147-169, 190-212, 222-244, 280-302, 526-548, 582-604 and 619-641 40041005213 PS00639 Eukaryotic thiol (cysteine) proteases histidine active site. 40041005214 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 40041005215 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 40041005216 Walker A/P-loop; other site 40041005217 ATP binding site [chemical binding]; other site 40041005218 Q-loop/lid; other site 40041005219 ABC transporter signature motif; other site 40041005220 Walker B; other site 40041005221 D-loop; other site 40041005222 H-loop/switch region; other site 40041005223 HMMPfam hit to PF00005, ABC transporter related, score 2.1e-62 40041005224 PS00211 ABC transporters family signature. 40041005225 PS00017 ATP/GTP-binding site motif A (P-loop). 40041005226 PASTA domain. This domain is found at the C-termini of several Penicillin-binding proteins (PBPs) and bacterial serine/threonine kinases. It is a small globular fold consisting of 3 beta-sheets and an alpha-helix. The name PASTA is derived from PBP and...; Region: PASTA; cl02768 40041005227 oxaloacetate decarboxylase; Provisional; Region: PRK12331 40041005228 Pyruvate carboxylase and Transcarboxylase 5S, carboxyltransferase domain; Region: DRE_TIM_PC_TC_5S; cd07937 40041005229 active site 40041005230 catalytic residues [active] 40041005231 metal binding site [ion binding]; metal-binding site 40041005232 homodimer binding site [polypeptide binding]; other site 40041005233 HMMPfam hit to PF02436, Conserved carboxylase region, score 2.2e-57 40041005234 HMMPfam hit to PF00682, Pyruvate carboxyltransferase, score 3.3e-47 40041005235 2'-(5''-triphosphoribosyl)-3'- dephospho-CoA:apo-citrate lyase; Reviewed; Region: citX; PRK01392 40041005236 HMMPfam hit to PF03802, Apo-citrate lyase phosphoribosyl-dephospho-CoA transferase, score 9.1e-82 40041005237 Citrate lyase, alpha subunit [Energy production and conversion]; Region: CitF; COG3051 40041005238 Coenzyme A transferase; Region: CoA_trans; cl17247 40041005239 Acetyl-CoA hydrolase/transferase C-terminal domain; Region: AcetylCoA_hyd_C; pfam13336 40041005240 HMMPfam hit to PF04223, Citrate lyase, alpha subunit, score 0 40041005241 HpcH/HpaI aldolase/citrate lyase family; Region: HpcH_HpaI; cl17231 40041005242 HMMPfam hit to PF03328, HpcH/HpaI aldolase, score 5.3e-120 40041005243 citrate lyase subunit gamma; Provisional; Region: PRK13253 40041005244 HMMPfam hit to PF04953, Citrate lyase acyl carrier protein CitD, score 6.3e-63 40041005245 Oxaloacetate decarboxylase, gamma chain; Region: OAD_gamma; cl01458 40041005246 1 probable transmembrane helix predicted for SZO09770 by TMHMM2.0 at aa 13-35 40041005247 Na+-transporting oxaloacetate decarboxylase beta subunit; Region: OAD_beta; pfam03977 40041005248 HMMPfam hit to PF03977, Na+-transporting methylmalonyl-CoA/oxaloacetate decarboxylase, beta subunit, score 8.6e-263 40041005249 9 probable transmembrane helices predicted for SZO09780 by TMHMM2.0 at aa 7-29, 39-61, 73-95, 105-127, 134-156, 166-187, 208-230, 281-303 and 345-367 40041005250 acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated; Region: PRK06549 40041005251 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 40041005252 carboxyltransferase (CT) interaction site; other site 40041005253 biotinylation site [posttranslational modification]; other site 40041005254 HMMPfam hit to PF00364, Biotin/lipoyl attachment, score 3.2e-26 40041005255 PS00188 Biotin-requiring enzymes attachment site. 40041005256 H+/citrate symporter [Energy production and conversion]; Region: CitM; COG2851 40041005257 Citrate transporter; Region: CitMHS; pfam03600 40041005258 13 probable transmembrane helices predicted for SZO09810 by TMHMM2.0 at aa 2-19, 24-46, 85-107, 122-153, 160-182, 197-219, 258-275, 280-299, 319-341, 356-375, 382-404, 409-431 and 443-465 40041005259 HMMPfam hit to PF03600, Divalent ion symporter, score 6.8e-128 40041005260 PS00211 ABC transporters family signature. 40041005261 Transcriptional regulators [Transcription]; Region: GntR; COG1802 40041005262 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 40041005263 DNA-binding site [nucleotide binding]; DNA binding site 40041005264 FCD domain; Region: FCD; pfam07729 40041005265 HMMPfam hit to PF00392, Bacterial regulatory protein GntR, HTH, score 1.2e-08 40041005266 Predicted helix-turn-helix motif with score 1180.000, SD 3.21 at aa 43-64, sequence INEKEFSIALNISRTPIRYALG 40041005267 HMMPfam hit to PF07729, GntR, C-terminal, score 0.00014 40041005268 ATP:dephospho-CoA triphosphoribosyl transferase; Region: CitG; cl00768 40041005269 HMMPfam hit to PF01874, Triphosphoribosyl-dephospho-CoA protein, score 2.7e-62 40041005270 PS00881 Protein splicing signature. 40041005271 Putative ammonia monooxygenase [General function prediction only]; Region: AbrB; COG3180 40041005272 membrane protein AbrB duplication; Region: Gneg_AbrB_dup; TIGR03082 40041005273 membrane protein AbrB duplication; Region: Gneg_AbrB_dup; TIGR03082 40041005274 8 probable transmembrane helices predicted for SZO09840 by TMHMM2.0 at aa 20-42, 82-104, 109-131, 141-163, 197-219, 239-257, 269-291 and 330-352 40041005275 HMMPfam hit to PF05145, ammonia monooxygenase, score 4.8e-08 40041005276 Citrate lyase synthetase [Energy production and conversion]; Region: CitC; COG3053 40041005277 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 40041005278 active site 40041005279 nucleotide binding site [chemical binding]; other site 40041005280 HIGH motif; other site 40041005281 KMSKS motif; other site 40041005282 HMMPfam hit to PF00583, GCN5-related N-acetyltransferase, score 2.5e-06 40041005283 HMMPfam hit to PF08218, Citrate lyase ligase, C-terminal, score 9.8e-101 40041005284 tRNA (uracil-5-)-methyltransferase Gid; Reviewed; Region: PRK05335 40041005285 Glucose inhibited division protein A; Region: GIDA; pfam01134 40041005286 HMMPfam hit to PF01134, Glucose-inhibited division protein A, score 1.2e-183 40041005287 PS01281 Glucose inhibited division protein A family signature 2. 40041005288 Protein of unknown function (DUF3307); Region: DUF3307; pfam11750 40041005289 5 probable transmembrane helices predicted for SZO09870 by TMHMM2.0 at aa 52-74, 95-114, 129-151, 178-197 and 212-234 40041005290 DNA topoisomerase I; Validated; Region: PRK05582 40041005291 TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I. Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363 40041005292 active site 40041005293 interdomain interaction site; other site 40041005294 putative metal-binding site [ion binding]; other site 40041005295 nucleotide binding site [chemical binding]; other site 40041005296 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 40041005297 domain I; other site 40041005298 DNA binding groove [nucleotide binding] 40041005299 phosphate binding site [ion binding]; other site 40041005300 domain II; other site 40041005301 domain III; other site 40041005302 nucleotide binding site [chemical binding]; other site 40041005303 catalytic site [active] 40041005304 domain IV; other site 40041005305 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 40041005306 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 40041005307 HMMPfam hit to PF01396, DNA topoisomerase, type IA, zn finger, score 0.14 40041005308 HMMPfam hit to PF01396, DNA topoisomerase, type IA, zn finger, score 3.8e-14 40041005309 HMMPfam hit to PF01396, DNA topoisomerase, type IA, zn finger, score 2.2e-15 40041005310 HMMPfam hit to PF01131, DNA topoisomerase, type IA, central, score 5.3e-170 40041005311 PS00396 Prokaryotic DNA topoisomerase I active site. 40041005312 HMMPfam hit to PF01751, TOPRIM, score 1.1e-33 40041005313 DNA recombination-mediator protein A; Region: DNA_processg_A; pfam02481 40041005314 DNA protecting protein DprA; Region: dprA; TIGR00732 40041005315 HMMPfam hit to PF02481, SMF protein, score 6.4e-83 40041005316 bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182 40041005317 RNA/DNA hybrid binding site [nucleotide binding]; other site 40041005318 active site 40041005319 HMMPfam hit to PF01351, Ribonuclease HII/HIII, score 1.1e-72 40041005320 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 40041005321 GTPase YlqF; Reviewed; Region: rbgA; PRK09563 40041005322 Circularly permuted YlqF GTPase; Region: YlqF; cd01856 40041005323 GTP/Mg2+ binding site [chemical binding]; other site 40041005324 G4 box; other site 40041005325 G5 box; other site 40041005326 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 40041005327 G1 box; other site 40041005328 G1 box; other site 40041005329 GTP/Mg2+ binding site [chemical binding]; other site 40041005330 Switch I region; other site 40041005331 G2 box; other site 40041005332 G2 box; other site 40041005333 G3 box; other site 40041005334 G3 box; other site 40041005335 Switch II region; other site 40041005336 Switch II region; other site 40041005337 G4 box; other site 40041005338 G5 box; other site 40041005339 HMMPfam hit to PF01926, GTP-binding protein, HSR1-related, score 1.2e-19 40041005340 PS00017 ATP/GTP-binding site motif A (P-loop). 40041005341 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 40041005342 putative bacteriocin export ABC transporter, lactococcin 972 group; Region: L_ocin_972_ABC; TIGR03608 40041005343 Walker A/P-loop; other site 40041005344 ATP binding site [chemical binding]; other site 40041005345 Q-loop/lid; other site 40041005346 ABC transporter signature motif; other site 40041005347 Walker B; other site 40041005348 D-loop; other site 40041005349 H-loop/switch region; other site 40041005350 HMMPfam hit to PF00005, ABC transporter related, score 1.2e-53 40041005351 PS00092 N-6 Adenine-specific DNA methylases signature. 40041005352 PS00211 ABC transporters family signature. 40041005353 PS00017 ATP/GTP-binding site motif A (P-loop). 40041005354 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4652 40041005355 Protein of unknown function (DUF1430); Region: DUF1430; pfam07242 40041005356 HMMPfam hit to PF07242, Bacteriocin-associated integral membrane protein, score 2.1e-42 40041005357 8 probable transmembrane helices predicted for SZO09940 by TMHMM2.0 at aa 5-24, 151-173, 194-216, 231-253, 273-295, 567-589, 609-631 and 635-655 40041005358 PS00217 Sugar transport proteins signature 2. 40041005359 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 40041005360 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 40041005361 catalytic residues [active] 40041005362 1 probable transmembrane helix predicted for SZO09950 by TMHMM2.0 at aa 259-276 40041005363 HMMPfam hit to PF00085, Thioredoxin domain, score 0.011 40041005364 Bacteriocin class II with double-glycine leader peptide; Region: Bacteriocin_IIc; pfam10439 40041005365 6 probable transmembrane helices predicted for SZO09960 by TMHMM2.0 at aa 17-39, 160-182, 207-229, 266-288, 295-317 and 360-382 40041005366 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 40041005367 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 40041005368 ABC-type multidrug transport system, ATPase component; Region: ABC_drug_resistance_like; cd03264 40041005369 Walker A/P-loop; other site 40041005370 ATP binding site [chemical binding]; other site 40041005371 Q-loop/lid; other site 40041005372 ABC transporter signature motif; other site 40041005373 Walker B; other site 40041005374 D-loop; other site 40041005375 H-loop/switch region; other site 40041005376 HMMPfam hit to PF00005, ABC transporter related, score 4.2e-47 40041005377 PS00211 ABC transporters family signature. 40041005378 PS00017 ATP/GTP-binding site motif A (P-loop). 40041005379 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 40041005380 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 40041005381 active site 40041005382 phosphorylation site [posttranslational modification] 40041005383 intermolecular recognition site; other site 40041005384 dimerization interface [polypeptide binding]; other site 40041005385 LytTr DNA-binding domain; Region: LytTR; pfam04397 40041005386 HMMPfam hit to PF04397, LytTr DNA-binding region, score 3e-25 40041005387 HMMPfam hit to PF00072, Response regulator receiver, score 0.00048 40041005388 Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1917 40041005389 HMMPfam hit to PF07883, Cupin 2, conserved barrel, score 1.1e-09 40041005390 Methyltransferase domain; Region: Methyltransf_31; pfam13847 40041005391 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 40041005392 S-adenosylmethionine binding site [chemical binding]; other site 40041005393 HMMPfam hit to PF08241, Methyltransferase type 11, score 6e-25 40041005394 Domain of unknown function (DUF1836); Region: DUF1836; pfam08876 40041005395 HMMPfam hit to PF08876, Protein of unknown function DUF1836, score 3.4e-52 40041005396 Predicted membrane protein, hemolysin III homolog [General function prediction only]; Region: COG1272 40041005397 channel protein, hemolysin III family; Region: hlyIII; TIGR01065 40041005398 HMMPfam hit to PF03006, Hly-III related proteins, score 3.8e-59 40041005399 6 probable transmembrane helices predicted for SZO10040 by TMHMM2.0 at aa 20-42, 49-71, 106-128, 141-160, 164-186 and 193-215 40041005400 Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase [Lipid metabolism / General function prediction only]; Region: LCB5; COG1597 40041005401 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 40041005402 HMMPfam hit to PF00781, Diacylglycerol kinase, catalytic region, score 5.1e-28 40041005403 1 probable transmembrane helix predicted for SZO10060 by TMHMM2.0 at aa 4-26 40041005404 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 40041005405 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 40041005406 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 40041005407 ABC transporter; Region: ABC_tran_2; pfam12848 40041005408 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 40041005409 HMMPfam hit to PF00005, ABC transporter related, score 6.4e-35 40041005410 PS00211 ABC transporters family signature. 40041005411 PS00017 ATP/GTP-binding site motif A (P-loop). 40041005412 HMMPfam hit to PF00005, ABC transporter related, score 3.1e-44 40041005413 PS00211 ABC transporters family signature. 40041005414 PS00017 ATP/GTP-binding site motif A (P-loop). 40041005415 ECF-type riboflavin transporter, S component; Region: ECF-ribofla_trS; cl17272 40041005416 6 probable transmembrane helices predicted for SZO10090 by TMHMM2.0 at aa 7-25, 29-46, 66-88, 98-115, 122-141 and 145-164 40041005417 PS00178 Aminoacyl-transfer RNA synthetases class-I signature. 40041005418 pyridoxamine kinase; Validated; Region: PRK07105 40041005419 substrate binding site [chemical binding]; other site 40041005420 ATP binding site [chemical binding]; other site 40041005421 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 40041005422 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 40041005423 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 40041005424 DNA-binding site [nucleotide binding]; DNA binding site 40041005425 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 40041005426 pyridoxal 5'-phosphate binding site [chemical binding]; other site 40041005427 homodimer interface [polypeptide binding]; other site 40041005428 catalytic residue [active] 40041005429 HMMPfam hit to PF00392, Bacterial regulatory protein GntR, HTH, score 2.1e-13 40041005430 Predicted helix-turn-helix motif with score 1140.000, SD 3.07 at aa 28-49, sequence PSIRQLSQQYHCSKDTVQRALL 40041005431 HMMPfam hit to PF00155, Aminotransferase, class I and II, score 6.7e-05 40041005432 Predicted helix-turn-helix motif with score 1450.000, SD 4.13 at aa 174-195, sequence HRMEQLATSLGLPYQTIERDFN 40041005433 ATP cone domain; Region: ATP-cone; pfam03477 40041005434 HMMPfam hit to PF03477, ATP-cone, score 4.1e-26 40041005435 aspartate-semialdehyde dehydrogenase; Provisional; Region: PRK14874 40041005436 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 40041005437 HMMPfam hit to PF02774, Semialdehyde dehydrogenase, dimerisation region, score 1.2e-77 40041005438 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 40041005439 HMMPfam hit to PF01118, Semialdehyde dehydrogenase, NAD - binding, score 1.2e-45 40041005440 Phosphatidylserine/phosphatidylglycerophosphate/car diolipin synthases and related enzymes [Lipid metabolism]; Region: Cls; COG1502 40041005441 Putative catalytic domain, repeat 1, of Streptococcus mutans uncharacterized protein SMU_988 and similar proteins; Region: PLDc_SMU_988_like_1; cd09154 40041005442 putative active site [active] 40041005443 catalytic site [active] 40041005444 Putative catalytic domain, repeat 2, of Streptococcus mutans uncharacterized protein SMU_988 and similar proteins; Region: PLDc_SMU_988_like_2; cd09160 40041005445 putative active site [active] 40041005446 catalytic site [active] 40041005447 HMMPfam hit to PF00614, Phospholipase D/Transphosphatidylase, score 6e-06 40041005448 HMMPfam hit to PF00614, Phospholipase D/Transphosphatidylase, score 3.8e-10 40041005449 3 probable transmembrane helices predicted for SZO10140 by TMHMM2.0 at aa 20-42, 52-74 and 79-101 40041005450 Peptidase S8 family domain in Streptococcal C5a peptidases; Region: Peptidases_S8_C5a_Peptidase; cd07475 40041005451 putative active site [active] 40041005452 catalytic triad [active] 40041005453 PA: Protease-associated (PA) domain. The PA domain is an insert domain in a diverse fraction of proteases. The significance of the PA domain to many of the proteins in which it is inserted is undetermined. It may be a protein-protein interaction domain; Region: PA; cl08238 40041005454 Peptidase S8 family domain in Streptococcal C5a peptidases; Region: Peptidases_S8_C5a_Peptidase; cd07475 40041005455 Fn3-like domain (DUF1034); Region: DUF1034; pfam06280 40041005456 C-terminal domain of CHU protein family; Region: CHU_C; cl17875 40041005457 HMMPfam hit to PF00746, Surface protein from Gram-positive cocci, anchor region, score 0.00011 40041005458 HMMPfam hit to PF06280, Peptidase S8A, DUF1034 C-terminal, score 5e-22 40041005459 HMMPfam hit to PF00082, Peptidase S8 and S53, subtilisin, kexin, sedolisin, score 2.1e-13 40041005460 PS00138 Serine proteases, subtilase family, serine active site. 40041005461 HMMPfam hit to PF02225, Protease-associated PA, score 1e-16 40041005462 PS00019 Actinin-type actin-binding domain signature 1. 40041005463 formate--tetrahydrofolate ligase; Provisional; Region: PRK13505 40041005464 Formyltetrahydrofolate synthetase (FTHFS) catalyzes the ATP-dependent activation of formate ion via its addition to the N10 position of tetrahydrofolate. FTHFS is a highly expressed key enzyme in both the Wood-Ljungdahl pathway of autotrophic CO2...; Region: FTHFS; cd00477 40041005465 Potassium binding sites [ion binding]; other site 40041005466 Cesium cation binding sites [ion binding]; other site 40041005467 HMMPfam hit to PF01268, Formate-tetrahydrofolate ligase, FTHFS, score 0 40041005468 PS00721 Formate--tetrahydrofolate ligase signature 1. 40041005469 phosphopantothenate--cysteine ligase; Validated; Region: PRK06732 40041005470 HMMPfam hit to PF04127, DNA/pantothenate metabolism flavoprotein, C-terminal, score 4.5e-62 40041005471 phosphopantothenoylcysteine decarboxylase; Validated; Region: PRK07313 40041005472 Flavoprotein; Region: Flavoprotein; pfam02441 40041005473 HMMPfam hit to PF02441, Flavoprotein, score 1.7e-46 40041005474 Predicted membrane protein [Function unknown]; Region: COG4684 40041005475 Protein of unknown function (DUF3816); Region: DUF3816; pfam12822 40041005476 5 probable transmembrane helices predicted for SZO10190 by TMHMM2.0 at aa 15-37, 64-86, 96-118, 125-147 and 162-184 40041005477 This CD includes PGM2 (phosphoglucomutase 2) and PGM2L1 (phosphoglucomutase 2-like 1). The mammalian PGM2 is thought to be a phosphopentomutase that catalyzes the conversion of the nucleoside breakdown products, ribose-1-phosphate and...; Region: PGM2; cd05799 40041005478 Phosphomannomutase [Carbohydrate transport and metabolism]; Region: {ManB}; COG1109 40041005479 active site 40041005480 substrate binding site [chemical binding]; other site 40041005481 metal binding site [ion binding]; metal-binding site 40041005482 HMMPfam hit to PF02878, Phosphoglucomutase/phosphomannomutase alpha/beta/alpha domain I, score 5.1e-58 40041005483 Predicted helix-turn-helix motif with score 1215.000, SD 3.33 at aa 75-96, sequence ESKGEAAKKAGVAIAYDSRHFS 40041005484 PS00710 Phosphoglucomutase and phosphomannomutase phosphoserine signature. 40041005485 HMMPfam hit to PF02879, Phosphoglucomutase/phosphomannomutase alpha/beta/alpha domain II, score 0.0079 40041005486 HMMPfam hit to PF02880, Phosphoglucomutase/phosphomannomutase alpha/beta/alpha domain III, score 3e-07 40041005487 HMMPfam hit to PF00408, Phosphoglucomutase/phosphomannomutase C-terminal, score 0.0019 40041005488 Gene remnant 40041005489 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 40041005490 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 40041005491 TM-ABC transporter signature motif; other site 40041005492 9 probable transmembrane helices predicted for SZO10210 by TMHMM2.0 at aa 5-27, 34-56, 69-91, 98-120, 156-173, 199-221, 225-247, 252-274 and 284-306 40041005493 HMMPfam hit to PF02653, Bacterial inner-membrane translocator, score 7.3e-42 40041005494 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 40041005495 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 40041005496 TM-ABC transporter signature motif; other site 40041005497 10 probable transmembrane helices predicted for SZO10220 by TMHMM2.0 at aa 9-31, 51-70, 75-97, 107-129, 134-156, 194-213, 242-264, 268-290, 295-317 and 322-344 40041005498 HMMPfam hit to PF02653, Bacterial inner-membrane translocator, score 2.9e-53 40041005499 ABC-type uncharacterized transport systems, ATPase components [General function prediction only]; Region: COG3845 40041005500 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 40041005501 Walker A/P-loop; other site 40041005502 ATP binding site [chemical binding]; other site 40041005503 Q-loop/lid; other site 40041005504 ABC transporter signature motif; other site 40041005505 Walker B; other site 40041005506 D-loop; other site 40041005507 H-loop/switch region; other site 40041005508 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 40041005509 HMMPfam hit to PF00005, ABC transporter related, score 6.5e-20 40041005510 PS00211 ABC transporters family signature. 40041005511 HMMPfam hit to PF00005, ABC transporter related, score 8.8e-53 40041005512 PS00017 ATP/GTP-binding site motif A (P-loop). 40041005513 Uncharacterized ABC-type transport system, periplasmic component/surface lipoprotein [General function prediction only]; Region: Med; COG1744 40041005514 Periplasmic binding domain of basic membrane lipoprotein, PnrA, in Treponema pallidum and its homologs from other bacteria and Archaea; Region: PBP1_BmpA_PnrA_like; cd06354 40041005515 ligand binding site [chemical binding]; other site 40041005516 HMMPfam hit to PF02608, Basic membrane lipoprotein, score 4.5e-74 40041005517 PS00146 Beta-lactamase class-A active site. 40041005518 PS00227 Tubulin subunits alpha, beta, and gamma signature. 40041005519 PS00017 ATP/GTP-binding site motif A (P-loop). 40041005520 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 40041005521 Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283 40041005522 active site 40041005523 catalytic motif [active] 40041005524 Zn binding site [ion binding]; other site 40041005525 HMMPfam hit to PF00383, CMP/dCMP deaminase, zinc-binding, score 9.8e-23 40041005526 PS00903 Cytidine and deoxycytidylate deaminases zinc-binding region signature. 40041005527 2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family; Region: DeoC; cd00959 40041005528 intersubunit interface [polypeptide binding]; other site 40041005529 active site 40041005530 catalytic residue [active] 40041005531 HMMPfam hit to PF01791, Deoxyribose-phosphate aldolase/phospho-2-dehydro-3-deoxyheptonate aldolase, score 2.6e-81 40041005532 pyrimidine-nucleoside phosphorylase; Reviewed; Region: PRK06078 40041005533 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 40041005534 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 40041005535 Pyrimidine nucleoside phosphorylase C-terminal domain; Region: PYNP_C; pfam07831 40041005536 HMMPfam hit to PF07831, Pyrimidine nucleoside phosphorylase, C-terminal, score 2e-26 40041005537 HMMPfam hit to PF00591, Glycosyl transferase, family 3, score 5.9e-30 40041005538 HMMPfam hit to PF01588, tRNA-binding region, score 0.00025 40041005539 PS00647 Thymidine and pyrimidine-nucleoside phosphorylases signature. 40041005540 HMMPfam hit to PF02885, Glycosyl transferase, family 3, score 2e-21 40041005541 16S RNA G1207 methylase RsmC [Translation, ribosomal structure and biogenesis]; Region: RsmC; COG2813 40041005542 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 40041005543 S-adenosylmethionine binding site [chemical binding]; other site 40041005544 HMMPfam hit to PF05175, Methyltransferase small, score 1.8e-73 40041005545 PS00225 Crystallins beta and gamma 'Greek key' motif signature. 40041005546 pantothenate kinase; Provisional; Region: PRK05439 40041005547 Pantothenate kinase (PanK) catalyzes the phosphorylation of pantothenic acid to form 4'-phosphopantothenic, which is the first of five steps in coenzyme A (CoA) biosynthetic pathway. The reaction carried out by this enzyme is a key regulatory point...; Region: PanK; cd02025 40041005548 ATP-binding site [chemical binding]; other site 40041005549 CoA-binding site [chemical binding]; other site 40041005550 Mg2+-binding site [ion binding]; other site 40041005551 HMMPfam hit to PF00485, Phosphoribulokinase/uridine kinase, score 4.9e-07 40041005552 PS00017 ATP/GTP-binding site motif A (P-loop). 40041005553 30S ribosomal protein S20; Reviewed; Region: rpsT; PRK00239 40041005554 HMMPfam hit to PF01649, Ribosomal protein S20, score 1.3e-19 40041005555 Lipase. Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is "interfacial activation", the process of...; Region: Lipase; cl14883 40041005556 nucleophilic elbow; other site 40041005557 catalytic triad; other site 40041005558 PS00120 Lipases, serine active site. 40041005559 Possible gene remnant. Similar to the N-terminal region of Streptococcus agalactiae CJB111 uncharacterized protein UniProt:Q3DDH3 (EMBL:AAJQ01000032) (71 aa) fasta scores: E()=0.025, 40.000% id in 55 aa 40041005560 1 probable transmembrane helix predicted for SZO10360 by TMHMM2.0 at aa 13-32 40041005561 Probable gene remnant. Similar to the N-terminal region of Streptococcus suis 89/1591 uncharacterized protein UniProt:Q303P3 (EMBL:AAFA02000002) (77 aa) fasta scores: E()=0.11, 43.4% id in 53 aa 40041005562 1 probable transmembrane helix predicted for SZO10420 by TMHMM2.0 at aa 12-31 40041005563 CDS contains a nonsense mutation (amber) after codon 17 40041005564 1 probable transmembrane helix predicted for SZO10440 by TMHMM2.0 at aa 12-34 40041005565 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 40041005566 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 40041005567 dimer interface [polypeptide binding]; other site 40041005568 phosphorylation site [posttranslational modification] 40041005569 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 40041005570 ATP binding site [chemical binding]; other site 40041005571 Mg2+ binding site [ion binding]; other site 40041005572 G-X-G motif; other site 40041005573 HMMPfam hit to PF02518, ATP-binding region, ATPase-like, score 6.5e-36 40041005574 HMMPfam hit to PF00512, Histidine kinase A, N-terminal, score 1.4e-10 40041005575 2 probable transmembrane helices predicted for SZO10450 by TMHMM2.0 at aa 7-29 and 177-199 40041005576 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 40041005577 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 40041005578 active site 40041005579 phosphorylation site [posttranslational modification] 40041005580 intermolecular recognition site; other site 40041005581 dimerization interface [polypeptide binding]; other site 40041005582 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 40041005583 DNA binding site [nucleotide binding] 40041005584 HMMPfam hit to PF00486, Transcriptional regulatory protein, C-terminal, score 3e-14 40041005585 HMMPfam hit to PF00072, Response regulator receiver, score 2.6e-28 40041005586 Peptidase M1 Aminopeptidase N family incudes tricorn interacting factor F3, Endoplasmic reticulum aminopeptidase 1 (ERAP1), Aminopeptidase Q (APQ); Region: M1_APN_2; cd09601 40041005587 Aminopeptidase N [Amino acid transport and metabolism]; Region: PepN; COG0308 40041005588 Zn binding site [ion binding]; other site 40041005589 HMMPfam hit to PF01433, Peptidase M1, membrane alanine aminopeptidase, N-terminal, score 3.9e-167 40041005590 PS00142 Neutral zinc metallopeptidases, zinc-binding region signature. 40041005591 phosphate transport system regulatory protein PhoU; Region: phoU_full; TIGR02135 40041005592 PhoU domain; Region: PhoU; pfam01895 40041005593 PhoU domain; Region: PhoU; pfam01895 40041005594 HMMPfam hit to PF01895, PhoU, score 6.8e-12 40041005595 HMMPfam hit to PF01895, PhoU, score 1.2e-31 40041005596 phosphate transporter ATP-binding protein; Provisional; Region: PRK14239 40041005597 ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260 40041005598 Walker A/P-loop; other site 40041005599 ATP binding site [chemical binding]; other site 40041005600 Q-loop/lid; other site 40041005601 ABC transporter signature motif; other site 40041005602 Walker B; other site 40041005603 D-loop; other site 40041005604 H-loop/switch region; other site 40041005605 HMMPfam hit to PF00005, ABC transporter related, score 2.3e-50 40041005606 PS00211 ABC transporters family signature. 40041005607 PS00017 ATP/GTP-binding site motif A (P-loop). 40041005608 phosphate transporter ATP-binding protein; Provisional; Region: PRK14237 40041005609 ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260 40041005610 Walker A/P-loop; other site 40041005611 ATP binding site [chemical binding]; other site 40041005612 Q-loop/lid; other site 40041005613 ABC transporter signature motif; other site 40041005614 Walker B; other site 40041005615 D-loop; other site 40041005616 H-loop/switch region; other site 40041005617 HMMPfam hit to PF00005, ABC transporter related, score 1.2e-48 40041005618 PS00211 ABC transporters family signature. 40041005619 PS00017 ATP/GTP-binding site motif A (P-loop). 40041005620 ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstA; COG0581 40041005621 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 40041005622 dimer interface [polypeptide binding]; other site 40041005623 conserved gate region; other site 40041005624 putative PBP binding loops; other site 40041005625 ABC-ATPase subunit interface; other site 40041005626 HMMPfam hit to PF00528, Binding-protein-dependent transport systems inner membrane component, score 7.1e-36 40041005627 4 probable transmembrane helices predicted for SZO10510 by TMHMM2.0 at aa 12-34, 66-88, 109-131 and 258-280 40041005628 PS00402 Binding-protein-dependent transport systems inner membrane comp. sign. 40041005629 ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstC; COG0573 40041005630 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 40041005631 dimer interface [polypeptide binding]; other site 40041005632 conserved gate region; other site 40041005633 putative PBP binding loops; other site 40041005634 ABC-ATPase subunit interface; other site 40041005635 HMMPfam hit to PF00528, Binding-protein-dependent transport systems inner membrane component, score 7e-23 40041005636 6 probable transmembrane helices predicted for SZO10520 by TMHMM2.0 at aa 25-47, 92-114, 127-149, 159-181, 220-242 and 279-301 40041005637 PBP superfamily domain; Region: PBP_like_2; cl17296 40041005638 HMMPfam hit to PF01547, Bacterial extracellular solute-binding protein, family 1, score 2.3e-09 40041005639 PS00017 ATP/GTP-binding site motif A (P-loop). 40041005640 1 probable transmembrane helix predicted for SZO10530 by TMHMM2.0 at aa 7-26 40041005641 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 40041005642 rRNA (cytosine-C(5)-)-methyltransferase RsmF; Reviewed; Region: yebU; PRK11933 40041005643 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 40041005644 S-adenosylmethionine binding site [chemical binding]; other site 40041005645 pre-rRNA processing and ribosome biogenesis; Region: Nol1_Nop2_Fmu_2; pfam13636 40041005646 HMMPfam hit to PF01189, Bacterial Fmu (Sun)/eukaryotic nucleolar NOL1/Nop2p, score 2.4e-32 40041005647 PS00017 ATP/GTP-binding site motif A (P-loop). 40041005648 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 40041005649 Inositol-monophosphatase-like domains. This family of phosphatases is dependent on bivalent metal ions such as Mg++, and many members are inhibited by Li+ (which is thought to displace a bivalent ion in the active site). Substrates include fructose-1; Region: IMPase_like; cd01637 40041005650 active site 40041005651 HMMPfam hit to PF00459, Inositol monophosphatase, score 1.7e-31 40041005652 hypothetical protein; Provisional; Region: PRK04387 40041005653 HMMPfam hit to PF05256, Protein of unknown function UPF0223, score 6.3e-55 40041005654 Arsenate Reductase (ArsC) family, Spx subfamily; Spx is a unique RNA polymerase (RNAP)-binding protein present in bacilli and some mollicutes. It inhibits transcription by binding to the C-terminal domain of the alpha subunit of RNAP, disrupting complex...; Region: ArsC_Spx; cd03032 40041005655 ArsC family; Region: ArsC; pfam03960 40041005656 putative catalytic residues [active] 40041005657 thiol/disulfide switch; other site 40041005658 HMMPfam hit to PF03960, Arsenate reductase and related, score 8.8e-60 40041005659 bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627 40041005660 FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064 40041005661 active site 40041005662 Riboflavin kinase; Region: Flavokinase; pfam01687 40041005663 HMMPfam hit to PF01687, Riboflavin kinase, score 7.2e-50 40041005664 HMMPfam hit to PF06574, FAD synthetase, score 6.8e-60 40041005665 tRNA pseudouridine synthase B; Provisional; Region: truB; PRK02484 40041005666 Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573 40041005667 RNA binding site [nucleotide binding]; other site 40041005668 active site 40041005669 HMMPfam hit to PF01509, tRNA pseudouridine synthase B, N-terminal, score 1.2e-74 40041005670 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4487 40041005671 Uncharacterized protein conserved in bacteria (DUF2130); Region: DUF2130; pfam09903 40041005672 Predicted membrane protein [Function unknown]; Region: COG4129 40041005673 Bacterial protein of unknown function (DUF939); Region: DUF939; pfam06081 40041005674 DUF939 C-terminal domain; Region: DUF939_C; pfam11728 40041005675 HMMPfam hit to PF06081, Protein of unknown function DUF939, bacterial, score 2.8e-130 40041005676 4 probable transmembrane helices predicted for SZO10610 by TMHMM2.0 at aa 15-37, 58-80, 84-106 and 119-141 40041005677 EcoKI restriction-modification system protein HsdS; Provisional; Region: PRK09737 40041005678 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 40041005679 FtsX-like permease family; Region: FtsX; pfam02687 40041005680 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 40041005681 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 40041005682 FtsX-like permease family; Region: FtsX; pfam02687 40041005683 HMMPfam hit to PF02687, Protein of unknown function DUF214, permase predicted, score 1.6e-23 40041005684 8 probable transmembrane helices predicted for SZO10630 by TMHMM2.0 at aa 21-43, 344-366, 397-419, 439-461, 517-539, 750-769, 803-825 and 840-862 40041005685 HMMPfam hit to PF02687, Protein of unknown function DUF214, permase predicted, score 1e-27 40041005686 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 40041005687 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 40041005688 Walker A/P-loop; other site 40041005689 ATP binding site [chemical binding]; other site 40041005690 Q-loop/lid; other site 40041005691 ABC transporter signature motif; other site 40041005692 Walker B; other site 40041005693 D-loop; other site 40041005694 H-loop/switch region; other site 40041005695 HMMPfam hit to PF00005, ABC transporter related, score 5.6e-59 40041005696 PS00211 ABC transporters family signature. 40041005697 PS00017 ATP/GTP-binding site motif A (P-loop). 40041005698 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 40041005699 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 40041005700 HMMPfam hit to PF00440, Transcriptional regulator, TetR-like, DNA-binding, bacterial/archaeal, score 7.8e-08 40041005701 Predicted helix-turn-helix motif with score 1070.000, SD 2.83 at aa 28-49, sequence ITVSDLTKKAGVNRGTFYLHYR 40041005702 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 40041005703 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 40041005704 DNA-binding site [nucleotide binding]; DNA binding site 40041005705 TrkA-C domain; Region: TrkA_C; pfam02080 40041005706 HMMPfam hit to PF02080, TrkA-C, score 3.9e-15 40041005707 HMMPfam hit to PF00392, Bacterial regulatory protein GntR, HTH, score 1.4e-11 40041005708 Predicted helix-turn-helix motif with score 1306.000, SD 3.64 at aa 36-57, sequence KSRTTIASTFNVSPETARKGLN 40041005709 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1302 40041005710 HMMPfam hit to PF03780, Protein of unknown function DUF322, score 3.3e-42 40041005711 CsbD-like; Region: CsbD; pfam05532 40041005712 HMMPfam hit to PF05532, CsbD-like, score 5.9e-21 40041005713 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1302 40041005714 PS00327 Bacterial rhodopsins retinal binding site. 40041005715 HMMPfam hit to PF03780, Protein of unknown function DUF322, score 2.6e-40 40041005716 PS00867 Carbamoyl-phosphate synthase subdomain signature 2. 40041005717 Small integral membrane protein [Function unknown]; Region: COG5547 40041005718 2 probable transmembrane helices predicted for SZO10700 by TMHMM2.0 at aa 7-29 and 33-55 40041005719 2 probable transmembrane helices predicted for SZO10710 by TMHMM2.0 at aa 7-26 and 57-79 40041005720 Predicted membrane protein [Function unknown]; Region: COG2261 40041005721 HMMPfam hit to PF04226, Transglycosylase-associated protein, score 2.4e-14 40041005722 3 probable transmembrane helices predicted for SZO10720 by TMHMM2.0 at aa 4-26, 33-55 and 60-82 40041005723 ATP-dependent DNA helicase PcrA; Region: pcrA; TIGR01073 40041005724 Part of AAA domain; Region: AAA_19; pfam13245 40041005725 Family description; Region: UvrD_C_2; pfam13538 40041005726 HMMPfam hit to PF00580, DNA helicase, UvrD/REP type, score 7.9e-216 40041005727 PS00017 ATP/GTP-binding site motif A (P-loop). 40041005728 Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115 40041005729 amino acid carrier protein; Region: agcS; TIGR00835 40041005730 11 probable transmembrane helices predicted for SZO10740 by TMHMM2.0 at aa 25-47, 71-93, 103-125, 155-177, 192-214, 221-238, 248-270, 316-338, 353-375, 396-418 and 422-444 40041005731 HMMPfam hit to PF01235, Sodium:alanine symporter, score 4.7e-167 40041005732 PS00873 Sodium:alanine symporter family signature. 40041005733 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 40041005734 Cation efflux family; Region: Cation_efflux; pfam01545 40041005735 4 probable transmembrane helices predicted for SZO10750 by TMHMM2.0 at aa 15-37, 84-106, 116-138 and 184-206 40041005736 HMMPfam hit to PF01545, Cation efflux protein, score 3.1e-91 40041005737 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 40041005738 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 40041005739 substrate binding pocket [chemical binding]; other site 40041005740 membrane-bound complex binding site; other site 40041005741 hinge residues; other site 40041005742 HMMPfam hit to PF00497, Bacterial extracellular solute-binding protein, family 3, score 1.7e-79 40041005743 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 40041005744 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 40041005745 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 40041005746 Walker A/P-loop; other site 40041005747 ATP binding site [chemical binding]; other site 40041005748 Q-loop/lid; other site 40041005749 ABC transporter signature motif; other site 40041005750 Walker B; other site 40041005751 D-loop; other site 40041005752 H-loop/switch region; other site 40041005753 HMMPfam hit to PF00005, ABC transporter related, score 1.9e-57 40041005754 PS00211 ABC transporters family signature. 40041005755 PS00017 ATP/GTP-binding site motif A (P-loop). 40041005756 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 40041005757 dimer interface [polypeptide binding]; other site 40041005758 conserved gate region; other site 40041005759 ABC-ATPase subunit interface; other site 40041005760 HMMPfam hit to PF00528, Binding-protein-dependent transport systems inner membrane component, score 5.9e-33 40041005761 3 probable transmembrane helices predicted for SZO10780 by TMHMM2.0 at aa 15-37, 50-72 and 179-201 40041005762 Uncharacterized Zn-ribbon-containing protein involved in phosphonate metabolism [Inorganic ion transport and metabolism]; Region: PhnA; COG2824 40041005763 PhnA Zinc-Ribbon; Region: PhnA_Zn_Ribbon; pfam08274 40041005764 PhnA protein; Region: PhnA; pfam03831 40041005765 HMMPfam hit to PF03831, PhnA protein, C-terminal, score 6.2e-34 40041005766 HMMPfam hit to PF08274, PhnA protein, N-terminal, score 3.8e-14 40041005767 glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331 40041005768 Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans). The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714 40041005769 glutaminase active site [active] 40041005770 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 40041005771 dimer interface [polypeptide binding]; other site 40041005772 active site 40041005773 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 40041005774 dimer interface [polypeptide binding]; other site 40041005775 active site 40041005776 HMMPfam hit to PF01380, Sugar isomerase (SIS), score 1.6e-17 40041005777 HMMPfam hit to PF01380, Sugar isomerase (SIS), score 6.3e-30 40041005778 HMMPfam hit to PF00310, Glutamine amidotransferase, class-II, score 7.5e-29 40041005779 PS00443 Glutamine amidotransferases class-II active site. 40041005780 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 40041005781 The S24, S26 LexA/signal peptidase superfamily contains LexA-related and type I signal peptidase families. The S24 LexA protein domains include: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC 3.4.21.88), the...; Region: Peptidase_S24_S26; cl10465 40041005782 The S24, S26 LexA/signal peptidase superfamily contains LexA-related and type I signal peptidase families. The S24 LexA protein domains include: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC 3.4.21.88), the...; Region: Peptidase_S24_S26; cl10465 40041005783 HMMPfam hit to PF00717, Peptidase S24, S26A and S26B, C-terminal, score 0.00041 40041005784 1 probable transmembrane helix predicted for SZO10810 by TMHMM2.0 at aa 9-28 40041005785 pyruvate kinase; Provisional; Region: PRK05826 40041005786 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342 40041005787 domain interfaces; other site 40041005788 active site 40041005789 HMMPfam hit to PF02887, Pyruvate kinase, alpha/beta, score 9.8e-51 40041005790 HMMPfam hit to PF00224, Pyruvate kinase, barrel, score 1e-204 40041005791 Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to a subfamily of the PFKA family (cd00363) and include bacterial ATP-dependent...; Region: Bacterial_PFK; cd00763 40041005792 6-phosphofructokinase; Region: PFKA_ATP; TIGR02482 40041005793 active site 40041005794 ADP/pyrophosphate binding site [chemical binding]; other site 40041005795 dimerization interface [polypeptide binding]; other site 40041005796 allosteric effector site; other site 40041005797 fructose-1,6-bisphosphate binding site; other site 40041005798 HMMPfam hit to PF00365, Phosphofructokinase, score 3.9e-173 40041005799 DNA polymerase III DnaE; Reviewed; Region: dnaE; PRK07279 40041005800 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III; Region: PHP_PolIIIA; cd07431 40041005801 active site 40041005802 PHP Thumb interface [polypeptide binding]; other site 40041005803 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 40041005804 generic binding surface II; other site 40041005805 generic binding surface I; other site 40041005806 HMMPfam hit to PF01336, Nucleic acid binding, OB-fold, tRNA/helicase-type, score 1.4e-11 40041005807 HMMPfam hit to PF07733, Bacterial DNA polymerase III, alpha subunit, score 5.6e-244 40041005808 HMMPfam hit to PF02811, PHP, C-terminal, score 1e-15 40041005809 Predicted transcriptional regulators [Transcription]; Region: COG1725 40041005810 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 40041005811 DNA-binding site [nucleotide binding]; DNA binding site 40041005812 HMMPfam hit to PF00392, Bacterial regulatory protein GntR, HTH, score 2.5e-13 40041005813 Predicted helix-turn-helix motif with score 1258.000, SD 3.47 at aa 35-56, sequence PTVREYAEIAGVNPNTMQRALT 40041005814 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 40041005815 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 40041005816 Walker A/P-loop; other site 40041005817 ATP binding site [chemical binding]; other site 40041005818 Q-loop/lid; other site 40041005819 ABC transporter signature motif; other site 40041005820 Walker B; other site 40041005821 D-loop; other site 40041005822 H-loop/switch region; other site 40041005823 HMMPfam hit to PF00005, ABC transporter related, score 1e-33 40041005824 PS00017 ATP/GTP-binding site motif A (P-loop). 40041005825 6 probable transmembrane helices predicted for SZO10870 by TMHMM2.0 at aa 13-35, 58-80, 110-132, 160-182, 189-211 and 235-257 40041005826 Uncharacterized conserved protein [Function unknown]; Region: COG0398 40041005827 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 40041005828 5 probable transmembrane helices predicted for SZO10880 by TMHMM2.0 at aa 15-34, 55-74, 89-111, 143-162 and 172-194 40041005829 HMMPfam hit to PF09335, SNARE associated Golgi protein, score 5.6e-17 40041005830 1 probable transmembrane helix predicted for SZO10890 by TMHMM2.0 at aa 7-29 40041005831 Mac 1; Region: Mac-1; pfam09028 40041005832 HMMPfam hit to PF09028, Mac 1, score 5.6e-153 40041005833 1 probable transmembrane helix predicted for SZO10900 by TMHMM2.0 at aa 12-34 40041005834 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 40041005835 thiamine biosynthesis protein ThiI; Provisional; Region: PRK01565 40041005836 THUMP domain of thiamine biosynthesis protein ThiI; Region: THUMP_ThiI; cd11716 40041005837 ThiI is required for thiazole synthesis in the thiamine biosynthesis pathway. It belongs to the Adenosine Nucleotide Hydrolysis suoerfamily and predicted to bind to Adenosine nucleotide; Region: ThiI; cd01712 40041005838 Ligand Binding Site [chemical binding]; other site 40041005839 HMMPfam hit to PF02568, Thiamine biosynthesis protein, score 7.4e-94 40041005840 HMMPfam hit to PF02926, THUMP, score 5.5e-15 40041005841 Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104 40041005842 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 40041005843 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 40041005844 catalytic residue [active] 40041005845 HMMPfam hit to PF00266, Aminotransferase, class V, score 2.3e-72 40041005846 PS00595 Aminotransferases class-V pyridoxal-phosphate attachment site. 40041005847 glutathione reductase; Validated; Region: PRK06116 40041005848 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 40041005849 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 40041005850 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 40041005851 HMMPfam hit to PF02852, Pyridine nucleotide-disulphide oxidoreductase dimerisation region, score 3.7e-50 40041005852 HMMPfam hit to PF07992, FAD-dependent pyridine nucleotide-disulphide oxidoreductase, score 4.2e-64 40041005853 HMMPfam hit to PF00070, Pyridine nucleotide-disulphide oxidoreductase, NAD-binding region, score 1e-31 40041005854 PS00076 Pyridine nucleotide-disulphide oxidoreductases class-I active site. 40041005855 hypothetical protein; Provisional; Region: PRK13676 40041005856 HMMPfam hit to PF06133, Protein of unknown function DUF964, score 1.4e-55 40041005857 Chorismate synthase [Amino acid transport and metabolism]; Region: AroC; COG0082 40041005858 Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304 40041005859 Tetramer interface [polypeptide binding]; other site 40041005860 active site 40041005861 FMN-binding site [chemical binding]; other site 40041005862 HMMPfam hit to PF01264, Chorismate synthase, score 1.5e-161 40041005863 PS00788 Chorismate synthase signature 2. 40041005864 PS00787 Chorismate synthase signature 1. 40041005865 3-dehydroquinate dehydratase [Amino acid transport and metabolism]; Region: AroD; COG0710 40041005866 Type I 3-dehydroquinase, (3-dehydroquinate dehydratase or DHQase); Region: DHQase_I; cd00502 40041005867 active site 40041005868 catalytic residue [active] 40041005869 dimer interface [polypeptide binding]; other site 40041005870 HMMPfam hit to PF01487, Dehydroquinase class I, score 9.1e-40 40041005871 Predicted SAM-dependent methyltransferases [General function prediction only]; Region: COG1092 40041005872 Middle domain of the SAM-dependent methyltransferase RlmI and related proteins; Region: RlmI_M_like; cd11572 40041005873 putative RNA binding site [nucleotide binding]; other site 40041005874 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 40041005875 S-adenosylmethionine binding site [chemical binding]; other site 40041005876 Phosphoglycerol transferase and related proteins, alkaline phosphatase superfamily [Cell envelope biogenesis, outer membrane]; Region: MdoB; COG1368 40041005877 Sulfatase; Region: Sulfatase; pfam00884 40041005878 5 probable transmembrane helices predicted for SZO11000 by TMHMM2.0 at aa 13-35, 45-67, 74-96, 126-148 and 161-180 40041005879 HMMPfam hit to PF00884, Sulphatase, score 3.9e-32 40041005880 3 probable transmembrane helices predicted for SZO11010 by TMHMM2.0 at aa 7-26, 105-127 and 134-156 40041005881 HMMPfam hit to PF00746, Surface protein from Gram-positive cocci, anchor region, score 3.3e-05 40041005882 PS00343 Gram-positive cocci surface proteins 'anchoring' hexapeptide. 40041005883 Ribosomal protein L20; Region: Ribosomal_L20; cd07026 40041005884 23S rRNA binding site [nucleotide binding]; other site 40041005885 L21 binding site [polypeptide binding]; other site 40041005886 L13 binding site [polypeptide binding]; other site 40041005887 HMMPfam hit to PF00453, Ribosomal protein L20, score 3.3e-66 40041005888 Predicted helix-turn-helix motif with score 1159.000, SD 3.13 at aa 63-84, sequence TRINAAARMNGLSYSQLMHGLK 40041005889 PS00937 Ribosomal protein L20 signature. 40041005890 50S ribosomal protein L35; Reviewed; Region: rpmI; PRK00172 40041005891 HMMPfam hit to PF01632, Ribosomal protein L35, score 7.5e-20 40041005892 translation initiation factor IF-3; Reviewed; Region: infC; PRK00028 40041005893 Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198 40041005894 Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707 40041005895 HMMPfam hit to PF00707, Initiation factor 3, score 1.4e-44 40041005896 HMMPfam hit to PF05198, Initiation factor 3, score 1.1e-47 40041005897 PS00938 Initiation factor 3 signature. 40041005898 Helix-turn-helix domain; Region: HTH_28; pfam13518 40041005899 Winged helix-turn helix; Region: HTH_29; pfam13551 40041005900 Homeodomain-like domain; Region: HTH_32; pfam13565 40041005901 Integrase core domain; Region: rve; pfam00665 40041005902 PS00017 ATP/GTP-binding site motif A (P-loop). 40041005903 HMMPfam hit to PF00665, Integrase, catalytic core, score 1.1e-18 40041005904 cytidylate kinase; Provisional; Region: cmk; PRK00023 40041005905 Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020 40041005906 CMP-binding site; other site 40041005907 The sites determining sugar specificity; other site 40041005908 HMMPfam hit to PF02224, Cytidylate kinase region, score 9.4e-63 40041005909 PS00017 ATP/GTP-binding site motif A (P-loop). 40041005910 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 40041005911 HMMPfam hit to PF01476, Peptidoglycan-binding LysM, score 0.0017 40041005912 1 probable transmembrane helix predicted for SZO11070 by TMHMM2.0 at aa 30-52 40041005913 Ferredoxin [Energy production and conversion]; Region: Fer; COG1141 40041005914 2 probable transmembrane helices predicted for SZO11090 by TMHMM2.0 at aa 20-38 and 45-67 40041005915 peptidase T; Region: peptidase-T; TIGR01882 40041005916 M20 Peptidase T specifically cleaves tripeptides; Region: M20_peptT; cd03892 40041005917 metal binding site [ion binding]; metal-binding site 40041005918 dimer interface [polypeptide binding]; other site 40041005919 HMMPfam hit to PF01546, Peptidase M20, score 7e-10 40041005920 HMMPfam hit to PF07687, Peptidase M20, dimerisation, score 3.4e-22 40041005921 PS00759 ArgE / dapE / ACY1 / CPG2 / yscS family signature 2. 40041005922 PS00758 ArgE / dapE / ACY1 / CPG2 / yscS family signature 1. 40041005923 UDP-glucose 4-epimerase; Region: PLN02240 40041005924 UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247 40041005925 NAD binding site [chemical binding]; other site 40041005926 homodimer interface [polypeptide binding]; other site 40041005927 active site 40041005928 substrate binding site [chemical binding]; other site 40041005929 HMMPfam hit to PF01370, NAD-dependent epimerase/dehydratase, score 5.5e-79 40041005930 Sulfatase; Region: Sulfatase; pfam00884 40041005931 HMMPfam hit to PF00884, Sulphatase, score 9e-54 40041005932 8 probable transmembrane helices predicted for SZO11120 by TMHMM2.0 at aa 18-40, 57-74, 136-158, 163-185, 195-217, 222-241, 269-291 and 304-326 40041005933 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 40041005934 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 40041005935 HMMPfam hit to PF00534, Glycosyl transferase, group 1, score 2.3e-29 40041005936 Predicted membrane protein [Function unknown]; Region: COG4713 40041005937 12 probable transmembrane helices predicted for SZO11140 by TMHMM2.0 at aa 15-33, 40-57, 61-80, 151-173, 178-200, 227-244, 259-281, 294-316, 370-392, 405-427, 442-461 and 473-490 40041005938 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 40041005939 Polysaccharide biosynthesis protein; Region: Polysacc_synt_3; pfam13440 40041005940 10 probable transmembrane helices predicted for SZO11150 by TMHMM2.0 at aa 13-35, 82-104, 147-164, 168-186, 207-226, 246-268, 295-317, 332-354, 361-380 and 385-407 40041005941 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 40041005942 3 probable transmembrane helices predicted for SZO11160 by TMHMM2.0 at aa 4-21, 34-56 and 66-85 40041005943 dolichyl-phosphate beta-D-mannosyltransferase; Region: PLN02726 40041005944 DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179 40041005945 Ligand binding site; other site 40041005946 Putative Catalytic site; other site 40041005947 DXD motif; other site 40041005948 HMMPfam hit to PF00535, Glycosyl transferase, family 2, score 2.5e-33 40041005949 Rhamnan synthesis protein F; Region: RgpF; pfam05045 40041005950 HMMPfam hit to PF05045, Rhamnan synthesis F, score 1.3e-281 40041005951 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 40041005952 Glycosyl transferase family 2; Region: Glycos_transf_2; pfam00535 40041005953 active site 40041005954 HMMPfam hit to PF00535, Glycosyl transferase, family 2, score 2.9e-34 40041005955 ABC-type polysaccharide/polyol phosphate transport system, ATPase component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagH; COG1134 40041005956 ATP-binding cassette component of polysaccharide transport system; Region: ABC_KpsT_Wzt; cd03220 40041005957 Walker A/P-loop; other site 40041005958 ATP binding site [chemical binding]; other site 40041005959 Q-loop/lid; other site 40041005960 ABC transporter signature motif; other site 40041005961 Walker B; other site 40041005962 D-loop; other site 40041005963 H-loop/switch region; other site 40041005964 HMMPfam hit to PF00005, ABC transporter related, score 2.3e-39 40041005965 PS00211 ABC transporters family signature. 40041005966 PS00017 ATP/GTP-binding site motif A (P-loop). 40041005967 ABC-type polysaccharide/polyol phosphate export systems, permease component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagG; COG1682 40041005968 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 40041005969 6 probable transmembrane helices predicted for SZO11210 by TMHMM2.0 at aa 28-50, 65-87, 107-129, 144-166, 173-195 and 235-257 40041005970 HMMPfam hit to PF01061, ABC-2 type transporter, score 9.4e-17 40041005971 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 40041005972 Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_d; cd04196 40041005973 Probable Catalytic site; other site 40041005974 HMMPfam hit to PF00535, Glycosyl transferase, family 2, score 5.5e-23 40041005975 This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_6; cd04955 40041005976 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 40041005977 HMMPfam hit to PF09314, Protein of unknown function DUF1972, score 6.6e-134 40041005978 dTDP-6-deoxy-L-lyxo-4-hexulose reductase and related proteins, extended (e) SDRs; Region: dTDP_HR_like_SDR_e; cd05254 40041005979 RmlD substrate binding domain; Region: RmlD_sub_bind; pfam04321 40041005980 NADP binding site [chemical binding]; other site 40041005981 active site 40041005982 putative substrate binding site [chemical binding]; other site 40041005983 HMMPfam hit to PF04321, dTDP-4-dehydrorhamnose reductase, score 1.4e-142 40041005984 Predicted metal-sulfur cluster biosynthetic enzyme [General function prediction only]; Region: PaaD; COG2151 40041005985 HMMPfam hit to PF01883, Protein of unknown function DUF59, score 1.1e-38 40041005986 RNA polymerase sigma factor RpoD; Validated; Region: PRK09210 40041005987 Sigma-70 factor, region 1.1; Region: Sigma70_r1_1; pfam03979 40041005988 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 40041005989 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 40041005990 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 40041005991 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 40041005992 DNA binding residues [nucleotide binding] 40041005993 HMMPfam hit to PF04545, RNA polymerase sigma-70 region 4, score 1e-26 40041005994 PS00716 Sigma-70 factors family signature 2. 40041005995 Predicted helix-turn-helix motif with score 1807.000, SD 5.34 at aa 327-348, sequence RTLEDVGKVFNVTRERIRQIEA 40041005996 HMMPfam hit to PF04539, RNA polymerase sigma-70 region 3, score 4.5e-41 40041005997 Predicted helix-turn-helix motif with score 985.000, SD 2.54 at aa 234-255, sequence PTPEQIAERMEMTPDKVREILK 40041005998 HMMPfam hit to PF04542, RNA polymerase sigma-70 region 2, score 1.3e-29 40041005999 PS00715 Sigma-70 factors family signature 1. 40041006000 HMMPfam hit to PF00140, RNA polymerase sigma-70 region 1.2, score 2.2e-15 40041006001 HMMPfam hit to PF03979, RNA polymerase sigma factor 70, region 1.1, score 1.3e-05 40041006002 DNA primase; Validated; Region: dnaG; PRK05667 40041006003 CHC2 zinc finger; Region: zf-CHC2; pfam01807 40041006004 DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275 40041006005 TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364 40041006006 active site 40041006007 metal binding site [ion binding]; metal-binding site 40041006008 interdomain interaction site; other site 40041006009 DnaB-helicase binding domain of primase; Region: DnaB_bind; pfam10410 40041006010 HMMPfam hit to PF01751, TOPRIM, score 1.3e-16 40041006011 HMMPfam hit to PF08275, DNA primase catalytic core, N-terminal, score 2.3e-54 40041006012 HMMPfam hit to PF01807, Zinc finger, CHC2-type, score 2.8e-45 40041006013 Large-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscL; COG1970 40041006014 large-conductance mechanosensitive channel; Reviewed; Region: mscL; PRK00567 40041006015 HMMPfam hit to PF01741, Large-conductance mechanosensitive channel, score 1.8e-40 40041006016 PS01327 Large-conductance mechanosensitive channels mscL family signature. 40041006017 2 probable transmembrane helices predicted for SZO11280 by TMHMM2.0 at aa 13-35 and 68-87 40041006018 30S ribosomal protein S21; Reviewed; Region: rpsU; PRK00270 40041006019 HMMPfam hit to PF01165, Ribosomal protein S21, score 1.1e-30 40041006020 PS01181 Ribosomal protein S21 signature. 40041006021 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 40041006022 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 40041006023 substrate binding pocket [chemical binding]; other site 40041006024 membrane-bound complex binding site; other site 40041006025 hinge residues; other site 40041006026 HMMPfam hit to PF00497, Bacterial extracellular solute-binding protein, family 3, score 1.9e-56 40041006027 transaminase; Validated; Region: PRK07324 40041006028 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 40041006029 pyridoxal 5'-phosphate binding site [chemical binding]; other site 40041006030 homodimer interface [polypeptide binding]; other site 40041006031 catalytic residue [active] 40041006032 HMMPfam hit to PF00155, Aminotransferase, class I and II, score 7.3e-37 40041006033 PS00105 Aminotransferases class-I pyridoxal-phosphate attachment site. 40041006034 helicase-exonuclease AddAB, AddA subunit, Firmicutes type; Region: addA_Gpos; TIGR02785 40041006035 Family description; Region: UvrD_C_2; pfam13538 40041006036 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 40041006037 PS00225 Crystallins beta and gamma 'Greek key' motif signature. 40041006038 HMMPfam hit to PF00580, DNA helicase, UvrD/REP type, score 1.7e-84 40041006039 PS00017 ATP/GTP-binding site motif A (P-loop). 40041006040 ATP-dependent nuclease subunit B; Region: rexB_recomb; TIGR02774 40041006041 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 40041006042 poly-beta-1,6 N-acetyl-D-glucosamine synthase; Region: PgaC_IcaA; TIGR03937 40041006043 CESA_like is the cellulose synthase superfamily; Region: CESA_like; cd06423 40041006044 DXD motif; other site 40041006045 4 probable transmembrane helices predicted for SZO11340 by TMHMM2.0 at aa 15-37, 347-369, 379-401 and 414-436 40041006046 PS00290 Immunoglobulins and major histocompatibility complex proteins signature. 40041006047 HMMPfam hit to PF00535, Glycosyl transferase, family 2, score 1.1e-25 40041006048 CotH protein; Region: CotH; pfam08757 40041006049 HMMPfam hit to PF08757, Spore coat protein CotH, score 1.5e-84 40041006050 1 probable transmembrane helix predicted for SZO11360 by TMHMM2.0 at aa 7-25 40041006051 3 probable transmembrane helices predicted for SZO11370 by TMHMM2.0 at aa 20-42, 64-86 and 99-121 40041006052 Predicted helix-turn-helix motif with score 1013.000, SD 2.64 at aa 42-63, sequence HTGTAYSKKFNVSLMTLTVLTA 40041006053 Polyphosphate(polyP) polymerase domain of yeast vacuolar transport chaperone (VTC) proteins VTC-2, -3 and- 4, and similar proteins; Region: PolyPPase_VTC_like; cd07750 40041006054 putative metal binding residues [ion binding]; other site 40041006055 signature motif; other site 40041006056 dimer interface [polypeptide binding]; other site 40041006057 active site 40041006058 polyP binding site; other site 40041006059 substrate binding site [chemical binding]; other site 40041006060 acceptor-phosphate pocket; other site 40041006061 Putative zinc-finger; Region: zf-HC2; pfam13490 40041006062 1 probable transmembrane helix predicted for SZO11390 by TMHMM2.0 at aa 78-100 40041006063 DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595 40041006064 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 40041006065 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 40041006066 DNA binding residues [nucleotide binding] 40041006067 HMMPfam hit to PF08281, RNA polymerase sigma factor 70, region 4 type 2, score 2.7e-10 40041006068 HMMPfam hit to PF04542, RNA polymerase sigma-70 region 2, score 2.5e-15 40041006069 PS01063 Sigma-70 factors ECF subfamily signature. 40041006070 PS00217 Sugar transport proteins signature 2. 40041006071 Gram-positive signal peptide, YSIRK family; Region: YSIRK_signal; TIGR01168 40041006072 pullulanase, extracellular, Gram-positive; Region: pullulan_Gpos; TIGR02102 40041006073 Family 41 Carbohydrate-Binding Module from pullulanase-like enzymes; Region: CBM41_pullulanase; cd10315 40041006074 carbohydrate binding site [chemical binding]; other site 40041006075 Family 41 Carbohydrate-Binding Module from pullulanase-like enzymes; Region: CBM41_pullulanase; cd10315 40041006076 carbohydrate binding site [chemical binding]; other site 40041006077 Early set domain associated with the catalytic domain of pullulanase (also called dextrinase and alpha-dextrin endo-1,6-alpha glucosidase); Region: E_set_Pullulanase; cd02860 40041006078 Alpha amylase catalytic domain found in Pullulanase (also called dextrinase; alpha-dextrin endo-1,6-alpha glucosidase), limit dextrinase, and related proteins; Region: AmyAc_Pullulanase_LD-like; cd11341 40041006079 Ca binding site [ion binding]; other site 40041006080 active site 40041006081 catalytic site [active] 40041006082 HMMPfam hit to PF00746, Surface protein from Gram-positive cocci, anchor region, score 7.9e-05 40041006083 PS00343 Gram-positive cocci surface proteins 'anchoring' hexapeptide. 40041006084 HMMPfam hit to PF00128, Glycosyl hydrolase, family 13, catalytic region, score 6.9e-15 40041006085 HMMPfam hit to PF02922, Glycoside hydrolase, family 13, N-terminal, score 3.5e-15 40041006086 HMMPfam hit to PF03714, Bacterial pullanase-associated protein, score 1.1e-31 40041006087 HMMPfam hit to PF03714, Bacterial pullanase-associated protein, score 1.4e-40 40041006088 1 probable transmembrane helix predicted for SZO11410 by TMHMM2.0 at aa 25-47 40041006089 HMMPfam hit to PF04650, YSIRK Gram-positive signal peptide, score 4.5e-07 40041006090 Ortholog of S. equi 4047 (FM204883) SEQ0943 40041006091 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 40041006092 Transposase; Region: DDE_Tnp_ISL3; pfam01610 40041006093 HMMPfam hit to PF01610, Transposase, IS204/IS1001/IS1096/IS1165, score 1.4e-47 40041006094 Predicted helix-turn-helix motif with score 1838.000, SD 5.45 at aa 119-140, sequence VSMTAIADRLSISTSTVMRKLN 40041006095 HMMPfam hit to PF00746, Surface protein from Gram-positive cocci, anchor region, score 4.2e-10 40041006096 1 probable transmembrane helix predicted for SZO11470 by TMHMM2.0 at aa 393-415 40041006097 PS00343 Gram-positive cocci surface proteins 'anchoring' hexapeptide. 40041006098 YSIRK type signal peptide; Region: YSIRK_signal; cl04650 40041006099 Mac 1; Region: Mac-1; pfam09028 40041006100 HMMPfam hit to PF09028, Mac 1, score 2.8e-15 40041006101 1 probable transmembrane helix predicted for SZO11480 by TMHMM2.0 at aa 20-39 40041006102 HMMPfam hit to PF04650, YSIRK Gram-positive signal peptide, score 0.00019 40041006103 Sortase C (SrtC) or subfamily-3 sortases are membrane cysteine transpeptidases found in Gram-positive bacteria that anchor surface proteins to peptidoglycans of the bacterial cell wall envelope. This involves a transpeptidation reaction in which the...; Region: Sortase_C_3; cd05827 40041006104 active site 40041006105 catalytic site [active] 40041006106 2 probable transmembrane helices predicted for SZO11490 by TMHMM2.0 at aa 5-27 and 241-263 40041006107 HMMPfam hit to PF04203, Peptidase C60, sortase A and B, score 2e-57 40041006108 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 40041006109 fimbrial isopeptide formation D2 domain; Region: RrgB_K2N_iso_D2; TIGR04226 40041006110 Domain of unknown function (DUF3244); Region: DUF3244; pfam11589 40041006111 HMMPfam hit to PF00746, Surface protein from Gram-positive cocci, anchor region, score 0.00047 40041006112 1 probable transmembrane helix predicted for SZO11500 by TMHMM2.0 at aa 453-475 40041006113 PS00343 Gram-positive cocci surface proteins 'anchoring' hexapeptide. 40041006114 HMMPfam hit to PF05738, Collagen-binding surface protein Cna-like, B region, score 5.3e-11 40041006115 Collagen binding domain; Region: Collagen_bind; pfam05737 40041006116 Repeat unit of collagen-binding protein domain B; Region: CollagenBindB; cd00222 40041006117 domain interaction interfaces [polypeptide binding]; other site 40041006118 Repeat unit of collagen-binding protein domain B; Region: CollagenBindB; cd00222 40041006119 domain interaction interfaces [polypeptide binding]; other site 40041006120 Repeat unit of collagen-binding protein domain B; Region: CollagenBindB; cd00222 40041006121 domain interaction interfaces [polypeptide binding]; other site 40041006122 1 probable transmembrane helix predicted for SZO11510 by TMHMM2.0 at aa 624-646 40041006123 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 40041006124 PS00343 Gram-positive cocci surface proteins 'anchoring' hexapeptide. 40041006125 HMMPfam hit to PF05738, Collagen-binding surface protein Cna-like, B region, score 7.2e-05 40041006126 HMMPfam hit to PF05738, Collagen-binding surface protein Cna-like, B region, score 4.5e-09 40041006127 HMMPfam hit to PF05738, Collagen-binding surface protein Cna-like, B region, score 3.8e-09 40041006128 HMMPfam hit to PF05737, Collagen binding, score 6.7e-53 40041006129 probable dihydroxyacetone kinase regulator; Region: DHAK_reg; TIGR02366 40041006130 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 40041006131 HMMPfam hit to PF00440, Transcriptional regulator, TetR-like, DNA-binding, bacterial/archaeal, score 8.6e-07 40041006132 Predicted helix-turn-helix motif with score 1921.000, SD 5.73 at aa 27-48, sequence ITISDISKASNISRTTFYHYFN 40041006133 HMMPfam hit to PF00746, Surface protein from Gram-positive cocci, anchor region, score 2.3e-12 40041006134 PS00343 Gram-positive cocci surface proteins 'anchoring' hexapeptide. 40041006135 HMMPfam hit to PF01468, Protein G-related, albumin-binding GA module, score 1.9e-18 40041006136 1 probable transmembrane helix predicted for SZO11530 by TMHMM2.0 at aa 13-32 40041006137 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 40041006138 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 40041006139 Walker A/P-loop; other site 40041006140 ATP binding site [chemical binding]; other site 40041006141 Q-loop/lid; other site 40041006142 ABC transporter signature motif; other site 40041006143 Walker B; other site 40041006144 D-loop; other site 40041006145 H-loop/switch region; other site 40041006146 HMMPfam hit to PF00005, ABC transporter related, score 1.7e-53 40041006147 PS00211 ABC transporters family signature. 40041006148 PS00017 ATP/GTP-binding site motif A (P-loop). 40041006149 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 40041006150 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 40041006151 HMMPfam hit to PF02687, Protein of unknown function DUF214, permase predicted, score 5.2e-21 40041006152 4 probable transmembrane helices predicted for SZO11550 by TMHMM2.0 at aa 13-35, 240-262, 282-304 and 324-346 40041006153 phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629 40041006154 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 40041006155 putative tRNA-binding site [nucleotide binding]; other site 40041006156 B3/4 domain; Region: B3_4; pfam03483 40041006157 tRNA synthetase B5 domain; Region: B5; smart00874 40041006158 Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA, PheRS is an...; Region: PheRS_beta_core; cd00769 40041006159 dimer interface [polypeptide binding]; other site 40041006160 motif 1; other site 40041006161 motif 3; other site 40041006162 motif 2; other site 40041006163 Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; pfam03147 40041006164 HMMPfam hit to PF03147, Phenylalanyl-tRNA synthetase, beta subunit, ferrodoxin-fold anticodon-binding, score 2.8e-29 40041006165 HMMPfam hit to PF03484, tRNA synthetase, B5, score 1e-25 40041006166 HMMPfam hit to PF03483, B3/4, score 3.8e-93 40041006167 PS00017 ATP/GTP-binding site motif A (P-loop). 40041006168 PS00017 ATP/GTP-binding site motif A (P-loop). 40041006169 HMMPfam hit to PF01588, tRNA-binding region, score 1.3e-20 40041006170 phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488 40041006171 Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912 40041006172 Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496 40041006173 dimer interface [polypeptide binding]; other site 40041006174 motif 1; other site 40041006175 active site 40041006176 motif 2; other site 40041006177 motif 3; other site 40041006178 HMMPfam hit to PF01409, Phenylalanyl-tRNA synthetase, class IIc, score 2.2e-170 40041006179 PS00179 Aminoacyl-transfer RNA synthetases class-II signature 1. 40041006180 HMMPfam hit to PF02912, Phenylalanyl-tRNA synthetase, class II, N-terminal, score 3.3e-28 40041006181 DNA/RNA non-specific endonuclease; Region: Endonuclease_NS; smart00892 40041006182 DNA/RNA non-specific endonuclease; Region: Endonuclea_NS_2; cl17626 40041006183 HMMPfam hit to PF01223, DNA/RNA non-specific endonuclease, score 1.9e-14 40041006184 PS01070 DNA/RNA non-specific endonucleases active site. 40041006185 1 probable transmembrane helix predicted for SZO11580 by TMHMM2.0 at aa 7-29 40041006186 DNA-directed RNA polymerase subunit beta; Region: EpuA; pfam11772 40041006187 1 probable transmembrane helix predicted for SZO11590 by TMHMM2.0 at aa 12-34 40041006188 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 40041006189 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 40041006190 hinge; other site 40041006191 active site 40041006192 HMMPfam hit to PF00275, 3-phosphoshikimate 1-carboxyvinyltransferase, score 8.2e-131 40041006193 PS00041 Bacterial regulatory proteins, araC family signature. 40041006194 Protein of unknown function (DUF1146); Region: DUF1146; cl11486 40041006195 2 probable transmembrane helices predicted for SZO11610 by TMHMM2.0 at aa 7-26 and 41-60 40041006196 F0F1 ATP synthase subunit epsilon; Validated; Region: atpC; PRK00571 40041006197 mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152 40041006198 gamma subunit interface [polypeptide binding]; other site 40041006199 epsilon subunit interface [polypeptide binding]; other site 40041006200 LBP interface [polypeptide binding]; other site 40041006201 HMMPfam hit to PF00401, ATPase, F1 complex, delta/epsilon subunit, score 7.8e-09 40041006202 HMMPfam hit to PF02823, ATPase, F1 complex, delta/epsilon subunit, score 1.3e-30 40041006203 F0F1 ATP synthase subunit beta; Validated; Region: PRK09280 40041006204 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 40041006205 F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133 40041006206 alpha subunit interaction interface [polypeptide binding]; other site 40041006207 Walker A motif; other site 40041006208 ATP binding site [chemical binding]; other site 40041006209 Walker B motif; other site 40041006210 inhibitor binding site; inhibition site 40041006211 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 40041006212 HMMPfam hit to PF00306, ATPase, F1/V1/A1 complex, alpha/beta subunit, C-terminal, score 7.4e-52 40041006213 HMMPfam hit to PF00006, ATPase, F1/V1/A1 complex, alpha/beta subunit, nucleotide-binding, score 1.6e-100 40041006214 PS00152 ATP synthase alpha and beta subunits signature. 40041006215 PS00017 ATP/GTP-binding site motif A (P-loop). 40041006216 HMMPfam hit to PF02874, ATPase, F1/V1/A1 complex, alpha/beta subunit, N-terminal, score 8.6e-26 40041006217 mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151 40041006218 core domain interface [polypeptide binding]; other site 40041006219 delta subunit interface [polypeptide binding]; other site 40041006220 epsilon subunit interface [polypeptide binding]; other site 40041006221 HMMPfam hit to PF00231, ATPase, F1 complex, gamma subunit, score 1.4e-124 40041006222 PS00153 ATP synthase gamma subunit signature. 40041006223 F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281 40041006224 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 40041006225 F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132 40041006226 beta subunit interaction interface [polypeptide binding]; other site 40041006227 Walker A motif; other site 40041006228 ATP binding site [chemical binding]; other site 40041006229 Walker B motif; other site 40041006230 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 40041006231 HMMPfam hit to PF00306, ATPase, F1/V1/A1 complex, alpha/beta subunit, C-terminal, score 1.3e-40 40041006232 HMMPfam hit to PF00006, ATPase, F1/V1/A1 complex, alpha/beta subunit, nucleotide-binding, score 6.9e-118 40041006233 PS00152 ATP synthase alpha and beta subunits signature. 40041006234 PS00017 ATP/GTP-binding site motif A (P-loop). 40041006235 HMMPfam hit to PF02874, ATPase, F1/V1/A1 complex, alpha/beta subunit, N-terminal, score 1.4e-20 40041006236 F0F1 ATP synthase subunit delta; Validated; Region: PRK05758 40041006237 ATP synthase delta (OSCP) subunit; Region: OSCP; pfam00213 40041006238 HMMPfam hit to PF00213, ATPase, F1 complex, OSCP/delta subunit, score 2.8e-25 40041006239 F0F1-type ATP synthase, subunit b [Energy production and conversion]; Region: AtpF; COG0711 40041006240 F0F1 ATP synthase subunit B; Validated; Region: PRK05759 40041006241 HMMPfam hit to PF00430, ATPase, F0 complex, subunit B/B', bacterial and chloroplast, score 8.1e-21 40041006242 1 probable transmembrane helix predicted for SZO11670 by TMHMM2.0 at aa 12-34 40041006243 F0F1-type ATP synthase, subunit a [Energy production and conversion]; Region: AtpB; COG0356 40041006244 F0F1 ATP synthase subunit A; Validated; Region: PRK05815 40041006245 HMMPfam hit to PF00119, ATPase, F0 complex, subunit A, score 2.3e-50 40041006246 5 probable transmembrane helices predicted for SZO11680 by TMHMM2.0 at aa 15-37, 75-97, 112-134, 167-189 and 199-221 40041006247 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 40041006248 PS00449 ATP synthase a subunit signature. 40041006249 F0F1 ATP synthase subunit C; Provisional; Region: PRK13467 40041006250 2 probable transmembrane helices predicted for SZO11690 by TMHMM2.0 at aa 4-26 and 42-64 40041006251 HMMPfam hit to PF00137, ATPase, F0/V0 complex, subunit C, score 4.3e-06 40041006252 PS00605 ATP synthase c subunit signature. 40041006253 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 40041006254 This is a family of oligosaccharide phosphorylases. It includes yeast and mammalian glycogen phosphorylases, plant starch/glucan phosphorylase, as well as the maltodextrin phosphorylases of bacteria. The members of this family catalyze the breakdown of...; Region: GT1_Glycogen_Phosphorylase; cd04300 40041006255 homodimer interface [polypeptide binding]; other site 40041006256 glycogen/starch/alpha-glucan phosphorylases; Region: P_ylase; TIGR02093 40041006257 active site pocket [active] 40041006258 HMMPfam hit to PF00343, Glycosyl transferase, family 35, score 0 40041006259 glycogen synthase; Provisional; Region: glgA; PRK00654 40041006260 This family is most closely related to the GT1 family of glycosyltransferases. Glycogen synthase catalyzes the formation and elongation of the alpha-1,4-glucose backbone using ADP-glucose, the second and key step of glycogen biosynthesis. This family...; Region: GT1_Glycogen_synthase_DULL1_like; cd03791 40041006261 ADP-binding pocket [chemical binding]; other site 40041006262 homodimer interface [polypeptide binding]; other site 40041006263 HMMPfam hit to PF00534, Glycosyl transferase, group 1, score 7.9e-05 40041006264 HMMPfam hit to PF08323, Starch synthase catalytic region, score 7.4e-131 40041006265 glucose-1-phosphate adenylyltransferase, GlgD subunit; Region: glgD; TIGR02092 40041006266 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 40041006267 active site 40041006268 Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651 40041006269 dimer interface [polypeptide binding]; other site 40041006270 N-terminal domain interface [polypeptide binding]; other site 40041006271 sulfate 1 binding site; other site 40041006272 HMMPfam hit to PF00483, Nucleotidyl transferase, score 2.5e-05 40041006273 glucose-1-phosphate adenylyltransferase; Provisional; Region: glgC; PRK05293 40041006274 ADP-glucose pyrophosphorylase is involved in the biosynthesis of glycogen or starch; Region: ADP_Glucose_PP; cd02508 40041006275 ligand binding site; other site 40041006276 oligomer interface; other site 40041006277 Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651 40041006278 dimer interface [polypeptide binding]; other site 40041006279 N-terminal domain interface [polypeptide binding]; other site 40041006280 sulfate 1 binding site; other site 40041006281 HMMPfam hit to PF00132, Bacterial transferase hexapeptide repeat, score 0.019 40041006282 HMMPfam hit to PF00132, Bacterial transferase hexapeptide repeat, score 7.4 40041006283 HMMPfam hit to PF00132, Bacterial transferase hexapeptide repeat, score 49 40041006284 HMMPfam hit to PF00483, Nucleotidyl transferase, score 8.3e-76 40041006285 PS00808 ADP-glucose pyrophosphorylase signature 1. 40041006286 glycogen branching enzyme; Provisional; Region: PRK12313 40041006287 N-terminal Early set domain associated with the catalytic domain of prokaryotic glycogen branching enzyme; Region: E_set_GBE_prok_N; cd02855 40041006288 Alpha amylase catalytic domain found in the Glycogen branching enzyme (also called 1,4-alpha-glucan branching enzyme); Region: AmyAc_Glg_BE; cd11322 40041006289 active site 40041006290 catalytic site [active] 40041006291 Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; pfam02806 40041006292 HMMPfam hit to PF02806, Alpha-amylase, C-terminal all beta, score 1.6e-23 40041006293 HMMPfam hit to PF00128, Glycosyl hydrolase, family 13, catalytic region, score 2e-05 40041006294 HMMPfam hit to PF02922, Glycoside hydrolase, family 13, N-terminal, score 7.2e-19 40041006295 Family 41 Carbohydrate-Binding Module from pullulanase-like enzymes; Region: CBM41_pullulanase; cd10315 40041006296 carbohydrate binding site [chemical binding]; other site 40041006297 pullulanase, type I; Region: pulA_typeI; TIGR02104 40041006298 Early set domain associated with the catalytic domain of pullulanase (also called dextrinase and alpha-dextrin endo-1,6-alpha glucosidase); Region: E_set_Pullulanase; cd02860 40041006299 Alpha amylase catalytic domain found in Pullulanase (also called dextrinase; alpha-dextrin endo-1,6-alpha glucosidase), limit dextrinase, and related proteins; Region: AmyAc_Pullulanase_LD-like; cd11341 40041006300 Ca binding site [ion binding]; other site 40041006301 active site 40041006302 catalytic site [active] 40041006303 HMMPfam hit to PF00128, Glycosyl hydrolase, family 13, catalytic region, score 2.1e-07 40041006304 HMMPfam hit to PF02922, Glycoside hydrolase, family 13, N-terminal, score 5.2e-07 40041006305 putative lipid kinase; Reviewed; Region: PRK13055 40041006306 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 40041006307 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; cl17465 40041006308 HMMPfam hit to PF00781, Diacylglycerol kinase, catalytic region, score 2.9e-45 40041006309 NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956 40041006310 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114 40041006311 nucleotide binding pocket [chemical binding]; other site 40041006312 K-X-D-G motif; other site 40041006313 catalytic site [active] 40041006314 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 40041006315 NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119 40041006316 Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027 40041006317 Dimer interface [polypeptide binding]; other site 40041006318 BRCT sequence motif; other site 40041006319 HMMPfam hit to PF00533, BRCT, score 5.2e-15 40041006320 HMMPfam hit to PF03119, Zinc-finger, NAD-dependent DNA ligase C4-type, score 5.1e-13 40041006321 HMMPfam hit to PF03120, NAD-dependent DNA ligase, OB-fold, score 1.8e-47 40041006322 PS01056 NAD-dependent DNA ligase signature 2. 40041006323 HMMPfam hit to PF01653, NAD-dependent DNA ligase, adenylation, score 3e-151 40041006324 PS01055 NAD-dependent DNA ligase signature 1. 40041006325 Predicted membrane protein [Function unknown]; Region: COG4708 40041006326 HMMPfam hit to PF06177, Protein of unknown function DUF988, score 6.8e-99 40041006327 5 probable transmembrane helices predicted for SZO11780 by TMHMM2.0 at aa 10-32, 45-67, 71-93, 109-131 and 135-157 40041006328 Predicted extracellular nuclease [General function prediction only]; Region: COG2374 40041006329 YhcR_OBF_like: A subfamily of OB-fold domains similar to the OB folds of Bacillus subtilis YhcR. YhcR is a sugar-nonspecific nuclease, which is active in the presence of Ca2+ and Mn2+. It cleaves RNA endonucleolytically, producing 3'-monophosphate...; Region: YhcR_OBF_like; cd04486 40041006330 generic binding surface II; other site 40041006331 generic binding surface I; other site 40041006332 YhcR_OBF_like: A subfamily of OB-fold domains similar to the OB folds of Bacillus subtilis YhcR. YhcR is a sugar-nonspecific nuclease, which is active in the presence of Ca2+ and Mn2+. It cleaves RNA endonucleolytically, producing 3'-monophosphate...; Region: YhcR_OBF_like; cd04486 40041006333 generic binding surface I; other site 40041006334 generic binding surface II; other site 40041006335 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 40041006336 putative catalytic site [active] 40041006337 putative metal binding site [ion binding]; other site 40041006338 putative phosphate binding site [ion binding]; other site 40041006339 1 probable transmembrane helix predicted for SZO11790 by TMHMM2.0 at aa 900-919 40041006340 PS00343 Gram-positive cocci surface proteins 'anchoring' hexapeptide. 40041006341 HMMPfam hit to PF03372, Endonuclease/exonuclease/phosphatase, score 5.9e-18 40041006342 HAD superfamily (subfamily IA) hydrolase, TIGR02253; Region: CTE7 40041006343 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 40041006344 motif II; other site 40041006345 HMMPfam hit to PF00702, Haloacid dehalogenase-like hydrolase, score 2.7e-11 40041006346 Cytotoxic translational repressor of toxin-antitoxin stability system [Translation, ribosomal structure and biogenesis / Cell division and chromosome partitioning]; Region: RelE; COG2026 40041006347 HMMPfam hit to PF05016, Plasmid stabilization system, score 2.2e-16 40041006348 Probable gene remnant 40041006349 enolase; Provisional; Region: eno; PRK00077 40041006350 Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313 40041006351 dimer interface [polypeptide binding]; other site 40041006352 metal binding site [ion binding]; metal-binding site 40041006353 substrate binding pocket [chemical binding]; other site 40041006354 HMMPfam hit to PF00113, Enolase, score 1.3e-164 40041006355 PS00164 Enolase signature. 40041006356 HMMPfam hit to PF03952, Enolase, score 2e-68 40041006357 Protein of unknown function (DUF1694); Region: DUF1694; pfam07997 40041006358 HMMPfam hit to PF07997, Protein of unknown function DUF1694, score 2.3e-39 40041006359 septation ring formation regulator EzrA; Provisional; Region: PRK04778 40041006360 HMMPfam hit to PF06160, Septation ring formation regulator, EzrA, score 0 40041006361 1 probable transmembrane helix predicted for SZO11860 by TMHMM2.0 at aa 5-27 40041006362 DNA gyrase subunit B; Validated; Region: gyrB; PRK05644 40041006363 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 40041006364 Mg2+ binding site [ion binding]; other site 40041006365 G-X-G motif; other site 40041006366 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 40041006367 anchoring element; other site 40041006368 dimer interface [polypeptide binding]; other site 40041006369 ATP binding site [chemical binding]; other site 40041006370 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 40041006371 active site 40041006372 putative metal-binding site [ion binding]; other site 40041006373 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 40041006374 HMMPfam hit to PF00986, DNA topoisomerase, type IIA, subunit B, C-terminal, score 1.2e-46 40041006375 HMMPfam hit to PF01751, TOPRIM, score 3.8e-09 40041006376 PS00177 DNA topoisomerase II signature. 40041006377 HMMPfam hit to PF00204, DNA topoisomerase, type IIA, subunit B, region 2, score 2.6e-93 40041006378 HMMPfam hit to PF02518, ATP-binding region, ATPase-like, score 1.7e-27 40041006379 haloacid dehalogenase superfamily, subfamily IA, variant 1 with third motif having Dx(3-4)D or Dx(3-4)E; Region: HAD-SF-IA-v1; TIGR01549 40041006380 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 40041006381 motif II; other site 40041006382 HMMPfam hit to PF00702, Haloacid dehalogenase-like hydrolase, score 9.6e-16 40041006383 Bacterial cell division membrane protein [Cell division and chromosome partitioning]; Region: FtsW; COG0772 40041006384 HMMPfam hit to PF01098, Cell cycle protein, score 3.1e-68 40041006385 10 probable transmembrane helices predicted for SZO11890 by TMHMM2.0 at aa 13-35, 50-72, 79-101, 107-129, 150-169, 173-192, 194-216, 288-310, 323-345 and 360-382 40041006386 NADP+-dependent non-phosphorylating glyceraldehyde 3-phosphate dehydrogenase and ALDH family 11; Region: ALDH_F11_NP-GAPDH; cd07082 40041006387 NADP-dependent glyceraldehyde-3-phosphate dehydrogenase; Provisional; Region: PLN00412 40041006388 tetrameric interface [polypeptide binding]; other site 40041006389 activator binding site; other site 40041006390 NADP binding site [chemical binding]; other site 40041006391 substrate binding site [chemical binding]; other site 40041006392 catalytic residues [active] 40041006393 HMMPfam hit to PF00171, Aldehyde dehydrogenase, score 2.9e-177 40041006394 PS00070 Aldehyde dehydrogenases cysteine active site. 40041006395 Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism]; Region: PtsA; COG1080 40041006396 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 40041006397 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 40041006398 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 40041006399 HMMPfam hit to PF02896, PEP-utilizing enzyme, score 1.5e-196 40041006400 PS00742 PEP-utilizing enzymes signature 2. 40041006401 HMMPfam hit to PF00391, PEP-utilising enzyme, mobile region, score 1.3e-41 40041006402 PS00370 PEP-utilizing enzymes phosphorylation site signature. 40041006403 HMMPfam hit to PF05524, Phosphotransferase system, PEP-utilising enzyme, N-terminal, score 1.4e-59 40041006404 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 40041006405 dimerization domain swap beta strand [polypeptide binding]; other site 40041006406 regulatory protein interface [polypeptide binding]; other site 40041006407 active site 40041006408 regulatory phosphorylation site [posttranslational modification]; other site 40041006409 HMMPfam hit to PF00381, Phosphotransferase system, phosphocarrier HPr protein, score 7.7e-53 40041006410 PS00589 PTS HPR component serine phosphorylation site signature. 40041006411 PS00369 PTS HPR component histidine phosphorylation site signature. 40041006412 NrdH-redoxin (NrdH) family; NrdH is a small monomeric protein with a conserved redox active CXXC motif within a TRX fold, characterized by a glutaredoxin (GRX)-like sequence and TRX-like activity profile. In vitro, it displays protein disulfide reductase...; Region: NrdH; cd02976 40041006413 catalytic residues [active] 40041006414 HMMPfam hit to PF00462, Glutaredoxin, score 3.3e-17 40041006415 ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK07306 40041006416 Ribonucleotide reductase N-terminal; Region: RNR_N; pfam08343 40041006417 Class I ribonucleotide reductase; Region: RNR_I; cd01679 40041006418 active site 40041006419 dimer interface [polypeptide binding]; other site 40041006420 catalytic residues [active] 40041006421 effector binding site; other site 40041006422 R2 peptide binding site; other site 40041006423 HMMPfam hit to PF08343, Ribonucleotide reductase N-terminal, score 1.8e-42 40041006424 HMMPfam hit to PF00317, Ribonucleotide reductase large subunit, N-terminal, score 6e-26 40041006425 HMMPfam hit to PF02867, Ribonucleotide reductase large subunit, C-terminal, score 5.3e-128 40041006426 PS00089 Ribonucleotide reductase large subunit signature. 40041006427 ribonucleotide-diphosphate reductase subunit beta; Provisional; Region: nrdF2; PRK13966 40041006428 Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049 40041006429 dimer interface [polypeptide binding]; other site 40041006430 putative radical transfer pathway; other site 40041006431 diiron center [ion binding]; other site 40041006432 tyrosyl radical; other site 40041006433 HMMPfam hit to PF00268, Ribonucleotide reductase, score 1.2e-61 40041006434 Putative ClC chloride channel. Clc proteins are putative halogen ion (Cl-, Br- and I-) transporters found in eubacteria. They belong to the ClC superfamily of halogen ion channels, which share a unique double-barreled architecture and voltage-dependent...; Region: ClC_like; cd01033 40041006435 putative ion selectivity filter; other site 40041006436 Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038 40041006437 putative pore gating glutamate residue; other site 40041006438 11 probable transmembrane helices predicted for SZO11960 by TMHMM2.0 at aa 7-29, 33-55, 62-79, 157-179, 186-208, 223-245, 258-280, 295-317, 324-341, 345-367 and 374-396 40041006439 HMMPfam hit to PF00654, Chloride channel, core, score 2.6e-07 40041006440 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 40041006441 Protein of unknown function (DUF3169); Region: DUF3169; pfam11368 40041006442 6 probable transmembrane helices predicted for SZO11970 by TMHMM2.0 at aa 20-42, 62-81, 108-130, 140-162, 204-226 and 230-247 40041006443 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 40041006444 non-specific DNA binding site [nucleotide binding]; other site 40041006445 salt bridge; other site 40041006446 sequence-specific DNA binding site [nucleotide binding]; other site 40041006447 HMMPfam hit to PF01381, Helix-turn-helix type 3, score 3.8e-15 40041006448 Predicted helix-turn-helix motif with score 1899.000, SD 5.65 at aa 18-39, sequence INQTQMAALAGVSRQTISLIER 40041006449 DNA/RNA non-specific endonuclease; Region: Endonuclease_NS; smart00892 40041006450 DNA/RNA non-specific endonuclease; Region: Endonuclea_NS_2; cl17626 40041006451 Predicted helix-turn-helix motif with score 1048.000, SD 2.76 at aa 4-25, sequence LTRKQKKEGIDMSRSRRRNWKS 40041006452 1 probable transmembrane helix predicted for SZO11990 by TMHMM2.0 at aa 25-42 40041006453 HMMPfam hit to PF01223, DNA/RNA non-specific endonuclease, score 2.1e-05 40041006454 50S ribosomal protein L19; Provisional; Region: rplS; PRK05338 40041006455 HMMPfam hit to PF01245, Ribosomal protein L19, score 8.6e-71 40041006456 PS01015 Ribosomal protein L19 signature. 40041006457 CLC voltage-gated chloride channel. The ClC chloride channels catalyse the selective flow of Cl- ions across cell membranes, thereby regulating electrical excitation in skeletal muscle and the flow of salt and water across epithelial barriers. This...; Region: Voltage_gated_ClC; cl02915 40041006458 Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038 40041006459 Cl- selectivity filter; other site 40041006460 Cl- binding residues [ion binding]; other site 40041006461 pore gating glutamate residue; other site 40041006462 dimer interface [polypeptide binding]; other site 40041006463 HMMPfam hit to PF00654, Chloride channel, core, score 6.6e-11 40041006464 10 probable transmembrane helices predicted for SZO12010 by TMHMM2.0 at aa 17-36, 51-73, 94-111, 146-168, 173-195, 215-237, 256-278, 320-339, 346-368 and 372-391 40041006465 hypothetical protein; Provisional; Region: PRK07248 40041006466 HMMPfam hit to PF01817, Chorismate mutase, score 9.8e-24 40041006467 DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; pfam13808 40041006468 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 40041006469 DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; cl17880 40041006470 HMMPfam hit to PF01609, Transposase, IS4-like, score 6.6e-17 40041006471 flavodoxin; Validated; Region: PRK07308 40041006472 HMMPfam hit to PF00258, Flavodoxin/nitric oxide synthase, score 2.3e-29 40041006473 PS00201 Flavodoxin signature. 40041006474 adenosine deaminase; Provisional; Region: PRK09358 40041006475 Adenosine deaminase [Nucleotide transport and metabolism]; Region: Add; COG1816 40041006476 active site 40041006477 HMMPfam hit to PF00962, Adenosine/AMP deaminase, score 2.6e-54 40041006478 HMMPfam hit to PF02828, L27, C-terminal, score 0.036 40041006479 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 40041006480 Coenzyme A binding pocket [chemical binding]; other site 40041006481 HMMPfam hit to PF00583, GCN5-related N-acetyltransferase, score 6.3e-09 40041006482 Exopolyphosphatase-related proteins [General function prediction only]; Region: COG0618 40041006483 DHH family; Region: DHH; pfam01368 40041006484 DHHA1 domain; Region: DHHA1; pfam02272 40041006485 HMMPfam hit to PF01368, Phosphoesterase, RecJ-like, score 1.2e-43 40041006486 HMMPfam hit to PF02272, Phosphoesterase, DHHA1, score 3.6e-06 40041006487 50S ribosomal protein L31 type B; Reviewed; Region: rpmE2; PRK01678 40041006488 HMMPfam hit to PF01197, Ribosomal protein L31, score 2.4e-21 40041006489 PS01143 Ribosomal protein L31 signature. 40041006490 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006 40041006491 active pocket/dimerization site; other site 40041006492 active site 40041006493 phosphorylation site [posttranslational modification] 40041006494 HMMPfam hit to PF03610, Phosphotransferase system, fructose subfamily IIA component, score 7e-27 40041006495 PTS system mannose/fructose/sorbose family IID component; Region: EIID-AGA; pfam03613 40041006496 HMMPfam hit to PF03613, Phosphotransferase system, mannose/fructose/sorbose family IID component, score 5.9e-103 40041006497 5 probable transmembrane helices predicted for SZO12100 by TMHMM2.0 at aa 115-132, 136-158, 179-201, 225-244 and 253-270 40041006498 Phosphotransferase system, mannose/fructose/N-acetylgalactosamine-specific component IIC [Carbohydrate transport and metabolism]; Region: ManY; COG3715 40041006499 6 probable transmembrane helices predicted for SZO12110 by TMHMM2.0 at aa 21-43, 47-69, 140-162, 182-204, 211-233 and 243-265 40041006500 HMMPfam hit to PF03609, Phosphotransferase system, sorbose-specific IIC subunit, score 2.8e-17 40041006501 PTS_IIB, PTS system, Mannose/sorbose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_man; cd00001 40041006502 active site 40041006503 phosphorylation site [posttranslational modification] 40041006504 HMMPfam hit to PF03830, Phosphotransferase system, sorbose subfamily IIB component, score 6.7e-67 40041006505 Beta-galactosidase [Carbohydrate transport and metabolism]; Region: LacA; COG1874 40041006506 Glycosyl hydrolases family 35; Region: Glyco_hydro_35; pfam01301 40041006507 HMMPfam hit to PF01301, Glycoside hydrolase, family 35, score 2e-173 40041006508 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 40041006509 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 40041006510 DNA-binding site [nucleotide binding]; DNA binding site 40041006511 The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; Region: UTRA; smart00866 40041006512 HMMPfam hit to PF00392, Bacterial regulatory protein GntR, HTH, score 9.5e-15 40041006513 Predicted helix-turn-helix motif with score 1112.000, SD 2.97 at aa 31-52, sequence YTEAELIKRFHVSSITIIRALK 40041006514 HMMPfam hit to PF07702, UbiC transcription regulator-associated, score 1.8e-07 40041006515 tagatose 1,6-diphosphate aldolase; Reviewed; Region: PRK04161 40041006516 HMMPfam hit to PF01791, Deoxyribose-phosphate aldolase/phospho-2-dehydro-3-deoxyheptonate aldolase, score 1.5e-102 40041006517 putative sugar isomerase, AgaS family; Region: agaS_fam; TIGR02815 40041006518 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 40041006519 dimer interface [polypeptide binding]; other site 40041006520 active site 40041006521 AgaS-like protein. AgaS contains a SIS (Sugar ISomerase) domain which is found in many phosphosugar isomerases and phosphosugar binding proteins. AgaS is a putative isomerase in Escherichia coli. It is similar to the glucosamine-6-phosphate synthases; Region: SIS_AgaS_like; cd05010 40041006522 putative active site [active] 40041006523 HMMPfam hit to PF01380, Sugar isomerase (SIS), score 7.8e-05 40041006524 HMMPfam hit to PF01380, Sugar isomerase (SIS), score 2e-07 40041006525 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 40041006526 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 40041006527 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 40041006528 DNA-binding site [nucleotide binding]; DNA binding site 40041006529 UTRA domain; Region: UTRA; pfam07702 40041006530 HMMPfam hit to PF07702, UbiC transcription regulator-associated, score 1.6e-44 40041006531 HMMPfam hit to PF00392, Bacterial regulatory protein GntR, HTH, score 4.4e-16 40041006532 PS00043 Bacterial regulatory proteins, gntR family signature. 40041006533 Predicted helix-turn-helix motif with score 1586.000, SD 4.59 at aa 30-51, sequence LSERELSDLFGVSRITIRLALK 40041006534 ABC-type metal ion transport system, periplasmic component/surface adhesin [Inorganic ion transport and metabolism]; Region: LraI; COG0803 40041006535 Metal binding protein AcdA. These proteins have been shown to function in the ABC uptake of Zn2+ and Mn2+ and in competence for genetic transformation and adhesion. The AcdA proteins belong to the TroA superfamily of helical backbone metal receptor...; Region: AdcA; cd01017 40041006536 metal binding site [ion binding]; metal-binding site 40041006537 YodA lipocalin-like domain; Region: YodA; pfam09223 40041006538 HMMPfam hit to PF09223, YodA, score 4.4e-136 40041006539 HMMPfam hit to PF01297, Periplasmic solute binding protein, score 3e-82 40041006540 Peptidase family C69; Region: Peptidase_C69; pfam03577 40041006541 HMMPfam hit to PF03577, Peptidase C69, dipeptidase A, score 4.7e-273 40041006542 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1481 40041006543 Sporulation Regulator WhiA N terminal; Region: WhiA_N; pfam10298 40041006544 HMMPfam hit to PF02650, Protein of unknown function DUF199, score 9.3e-65 40041006545 conserved hypothetical protein, cofD-related; Region: CofD_related; TIGR01826 40041006546 Family of CofD-like proteins and proteins related to YvcK; Region: CofD_YvcK; cd07044 40041006547 dimer interface [polypeptide binding]; other site 40041006548 phosphate binding site [ion binding]; other site 40041006549 HMMPfam hit to PF01933, Protein of unknown function UPF0052 and CofD, score 8.3e-146 40041006550 PS01036 Heat shock hsp70 proteins family signature 3. 40041006551 glmZ(sRNA)-inactivating NTPase; Provisional; Region: PRK05416 40041006552 AAA domain; Region: AAA_33; pfam13671 40041006553 HMMPfam hit to PF03668, P-loop ATPase protein, score 1.5e-126 40041006554 PS00017 ATP/GTP-binding site motif A (P-loop). 40041006555 PS00017 ATP/GTP-binding site motif A (P-loop). 40041006556 Collagen triple helix repeat (20 copies); Region: Collagen; pfam01391 40041006557 HMMPfam hit to PF00746, Surface protein from Gram-positive cocci, anchor region, score 1e-06 40041006558 1 probable transmembrane helix predicted for SZO12230 by TMHMM2.0 at aa 325-342 40041006559 PS00343 Gram-positive cocci surface proteins 'anchoring' hexapeptide. 40041006560 HMMPfam hit to PF01391, Collagen triple helix repeat, score 1.5e-14 40041006561 HMMPfam hit to PF01391, Collagen triple helix repeat, score 1.8e-11 40041006562 HMMPfam hit to PF01391, Collagen triple helix repeat, score 3.3e-14 40041006563 asparaginyl-tRNA synthetase; Validated; Region: asnC; PRK03932 40041006564 AsnRS_cyto_like_N: N-terminal, anticodon recognition domain of the type found in human and Saccharomyces cerevisiae cytoplasmic asparaginyl-tRNA synthetase (AsnRS), in Brugia malayai AsnRs and, in various putative bacterial AsnRSs. This domain is a...; Region: AsnRS_cyto_like_N; cd04323 40041006565 putative dimer interface [polypeptide binding]; other site 40041006566 putative anticodon binding site; other site 40041006567 Asx tRNA synthetase (AspRS/AsnRS) class II core domain. Assignment to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs in the core domain. This family includes AsnRS as well as...; Region: AsxRS_core; cd00776 40041006568 homodimer interface [polypeptide binding]; other site 40041006569 motif 1; other site 40041006570 motif 2; other site 40041006571 active site 40041006572 motif 3; other site 40041006573 HMMPfam hit to PF00152, Aminoacyl-tRNA synthetase, class II (D, K and N), score 1.6e-96 40041006574 PS00339 Aminoacyl-transfer RNA synthetases class-II signature 2. 40041006575 PS00179 Aminoacyl-transfer RNA synthetases class-II signature 1. 40041006576 HMMPfam hit to PF01336, Nucleic acid binding, OB-fold, tRNA/helicase-type, score 1.6e-17 40041006577 aspartate aminotransferase; Provisional; Region: PRK05764 40041006578 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 40041006579 pyridoxal 5'-phosphate binding site [chemical binding]; other site 40041006580 homodimer interface [polypeptide binding]; other site 40041006581 catalytic residue [active] 40041006582 HMMPfam hit to PF00155, Aminotransferase, class I and II, score 1.6e-93 40041006583 PS00105 Aminotransferases class-I pyridoxal-phosphate attachment site. 40041006584 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5353 40041006585 bifunctional ATP-dependent DNA helicase/DNA polymerase III subunit epsilon; Validated; Region: PRK07246 40041006586 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 40041006587 active site 40041006588 catalytic site [active] 40041006589 substrate binding site [chemical binding]; other site 40041006590 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 40041006591 ATP binding site [chemical binding]; other site 40041006592 Helicase C-terminal domain; Region: Helicase_C_2; pfam13307 40041006593 PS00017 ATP/GTP-binding site motif A (P-loop). 40041006594 HMMPfam hit to PF00929, Exonuclease, RNase T and DNA polymerase III, score 1.6e-34 40041006595 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 40041006596 HMMPfam hit to PF00753, Beta-lactamase-like, score 5.9e-35 40041006597 Cell division protein [Cell division and chromosome partitioning]; Region: FtsX; COG2177 40041006598 cell division ABC transporter subunit FtsX; Provisional; Region: ftsX; PRK11026 40041006599 HMMPfam hit to PF02687, Protein of unknown function DUF214, permase predicted, score 3e-34 40041006600 4 probable transmembrane helices predicted for SZO12290 by TMHMM2.0 at aa 23-45, 183-205, 235-257 and 282-304 40041006601 Predicted ATPase involved in cell division [Cell division and chromosome partitioning]; Region: FtsE; COG2884 40041006602 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 40041006603 Walker A/P-loop; other site 40041006604 ATP binding site [chemical binding]; other site 40041006605 Q-loop/lid; other site 40041006606 ABC transporter signature motif; other site 40041006607 Walker B; other site 40041006608 D-loop; other site 40041006609 H-loop/switch region; other site 40041006610 HMMPfam hit to PF00005, ABC transporter related, score 3.5e-61 40041006611 PS00211 ABC transporters family signature. 40041006612 PS00017 ATP/GTP-binding site motif A (P-loop). 40041006613 peptide chain release factor 2; Validated; Region: prfB; PRK00578 40041006614 This domain is found in peptide chain release factors; Region: PCRF; smart00937 40041006615 RF-1 domain; Region: RF-1; pfam00472 40041006616 HMMPfam hit to PF00472, Class I peptide chain release factor, score 5e-65 40041006617 HMMPfam hit to PF03462, PCRF, score 6.8e-58 40041006618 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 40041006619 ATP-binding cassette domain of multidrug resistance protein-like transporters; Region: ABCC_MRP_Like; cd03228 40041006620 Walker A/P-loop; other site 40041006621 ATP binding site [chemical binding]; other site 40041006622 Q-loop/lid; other site 40041006623 ABC transporter signature motif; other site 40041006624 Walker B; other site 40041006625 D-loop; other site 40041006626 H-loop/switch region; other site 40041006627 HMMPfam hit to PF00005, ABC transporter related, score 3.4e-32 40041006628 PS00211 ABC transporters family signature. 40041006629 PS00017 ATP/GTP-binding site motif A (P-loop). 40041006630 5 probable transmembrane helices predicted for SZO12320 by TMHMM2.0 at aa 7-29, 52-74, 115-137, 147-166 and 231-253 40041006631 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 40041006632 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 40041006633 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 40041006634 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 40041006635 ATP-binding cassette domain of multidrug resistance protein-like transporters; Region: ABCC_MRP_Like; cd03228 40041006636 Walker A/P-loop; other site 40041006637 ATP binding site [chemical binding]; other site 40041006638 Q-loop/lid; other site 40041006639 ABC transporter signature motif; other site 40041006640 Walker B; other site 40041006641 D-loop; other site 40041006642 H-loop/switch region; other site 40041006643 HMMPfam hit to PF00005, ABC transporter related, score 1e-35 40041006644 PS00211 ABC transporters family signature. 40041006645 PS00017 ATP/GTP-binding site motif A (P-loop). 40041006646 3 probable transmembrane helices predicted for SZO12330 by TMHMM2.0 at aa 20-42, 55-77 and 136-158 40041006647 5 probable transmembrane helices predicted for SZO12340 by TMHMM2.0 at aa 13-35, 45-67, 87-109, 124-146 and 158-180 40041006648 ABC-type polysaccharide/polyol phosphate export systems, permease component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagG; COG1682 40041006649 6 probable transmembrane helices predicted for SZO12350 by TMHMM2.0 at aa 44-66, 73-95, 123-145, 152-174, 194-216 and 236-258 40041006650 HMMPfam hit to PF01061, ABC-2 type transporter, score 0.0046 40041006651 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 40041006652 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 40041006653 Walker A/P-loop; other site 40041006654 ATP binding site [chemical binding]; other site 40041006655 Q-loop/lid; other site 40041006656 ABC transporter signature motif; other site 40041006657 Walker B; other site 40041006658 D-loop; other site 40041006659 H-loop/switch region; other site 40041006660 HMMPfam hit to PF00005, ABC transporter related, score 3.4e-43 40041006661 PS00017 ATP/GTP-binding site motif A (P-loop). 40041006662 mycofactocin radical SAM maturase; Region: mycofact_rSAM; TIGR03962 40041006663 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 40041006664 FeS/SAM binding site; other site 40041006665 radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085 40041006666 HMMPfam hit to PF04055, Radical SAM, score 1.4e-15 40041006667 Radical SAM superfamily; Region: Radical_SAM; pfam04055 40041006668 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 40041006669 FeS/SAM binding site; other site 40041006670 Domain of unknown function (DUF4008); Region: DUF4008; cl14869 40041006671 HMMPfam hit to PF04055, Radical SAM, score 8.3e-28 40041006672 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 40041006673 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 40041006674 non-specific DNA binding site [nucleotide binding]; other site 40041006675 salt bridge; other site 40041006676 sequence-specific DNA binding site [nucleotide binding]; other site 40041006677 transcriptional activator, Rgg/GadR/MutR family, C-terminal domain; Region: RGG_Cterm; TIGR01716 40041006678 HMMPfam hit to PF01381, Helix-turn-helix type 3, score 2.5e-08 40041006679 Bacterial cell division membrane protein [Cell division and chromosome partitioning]; Region: FtsW; COG0772 40041006680 HMMPfam hit to PF01098, Cell cycle protein, score 1.1e-89 40041006681 8 probable transmembrane helices predicted for SZO12410 by TMHMM2.0 at aa 13-35, 50-72, 77-99, 179-198, 203-225, 302-324, 337-359 and 364-386 40041006682 phosphoenolpyruvate carboxylase; Reviewed; Region: PRK00009 40041006683 Phosphoenolpyruvate carboxylase [Energy production and conversion]; Region: Ppc; COG2352 40041006684 HMMPfam hit to PF00311, Phosphoenolpyruvate carboxylase, score 5e-87 40041006685 PS00393 Phosphoenolpyruvate carboxylase active site 2. 40041006686 PS00781 Phosphoenolpyruvate carboxylase active site 1. 40041006687 oligoendopeptidase F; Region: pepF; TIGR00181 40041006688 Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins); Region: GluZincin; cl14813 40041006689 Zn binding site [ion binding]; other site 40041006690 HMMPfam hit to PF08439, Peptidase M3B, oligopeptidase F, N-terminal, score 1.6e-11 40041006691 HMMPfam hit to PF01432, Peptidase M3A and M3B, thimet/oligopeptidase F, score 1.3e-33 40041006692 PS00142 Neutral zinc metallopeptidases, zinc-binding region signature. 40041006693 Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per...; Region: GSH_Peroxidase; cd00340 40041006694 catalytic residues [active] 40041006695 dimer interface [polypeptide binding]; other site 40041006696 HMMPfam hit to PF00255, Glutathione peroxidase, score 1.8e-49 40041006697 PS00460 Glutathione peroxidases selenocysteine active site. 40041006698 PS00763 Glutathione peroxidases signature 2. 40041006699 Ortholog of S. equi 4047 (FM204883) SEQ0771; CDS contains a frameshifts after codons 155 and 302 40041006700 9 probable transmembrane helices predicted for SZO12460 by TMHMM2.0 at aa 41-63, 76-95, 99-121, 165-187, 242-264, 285-307, 311-328, 341-363 and 369-391 40041006701 4 probable transmembrane helices predicted for SZO12470 by TMHMM2.0 at aa 21-43, 48-70, 103-125 and 135-157 40041006702 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 40041006703 Lyzozyme M1 (1,4-beta-N-acetylmuramidase) [Cell envelope biogenesis, outer membrane]; Region: Acm; COG3757 40041006704 PlyB is a bacteriophage endolysin that displays potent lytic activity toward Bacillus anthracis. PlyB has an N-terminal glycosyl hydrolase family 25 (GH25) catalytic domain and a C-terminal bacterial SH3-like domain, SH3b. Both domains are required for...; Region: GH25_PlyB-like; cd06523 40041006705 active site 40041006706 1 probable transmembrane helix predicted for SZO12480 by TMHMM2.0 at aa 7-24 40041006707 HMMPfam hit to PF01183, Glycoside hydrolase, family 25, score 2.1e-06 40041006708 Thiamine transporter protein (Thia_YuaJ); Region: Thia_YuaJ; cl17491 40041006709 5 probable transmembrane helices predicted for SZO12490 by TMHMM2.0 at aa 13-35, 50-69, 74-96, 111-133 and 154-176 40041006710 This CD includes cysteinyl-tRNA(Pro) deacylases from Haemophilus influenzae and Escherichia coli and other related bacterial proteins. These trans-acting, single-domain proteins are homologs of ProX and also the cis-acting prolyl-tRNA synthetase (ProRS)...; Region: YbaK_deacylase; cd00002 40041006711 putative deacylase active site [active] 40041006712 HMMPfam hit to PF04073, YbaK/prolyl-tRNA synthetase associated region, score 1.4e-53 40041006713 hypothetical protein; Provisional; Region: PRK11770 40041006714 Domain of unknown function (DUF307); Region: DUF307; pfam03733 40041006715 Domain of unknown function (DUF307); Region: DUF307; pfam03733 40041006716 HMMPfam hit to PF03733, Protein of unknown function DUF307, score 3.4e-16 40041006717 3 probable transmembrane helices predicted for SZO12510 by TMHMM2.0 at aa 13-35, 50-72 and 79-101 40041006718 HMMPfam hit to PF03733, Protein of unknown function DUF307, score 3e-20 40041006719 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 40041006720 catalytic core [active] 40041006721 HMMPfam hit to PF00300, Phosphoglycerate mutase, score 8.3e-42 40041006722 Predicted ATPase (AAA+ superfamily) [General function prediction only]; Region: COG1373 40041006723 AAA domain; Region: AAA_14; pfam13173 40041006724 PS00017 ATP/GTP-binding site motif A (P-loop). 40041006725 putative transposase OrfB; Reviewed; Region: PHA02517 40041006726 HTH-like domain; Region: HTH_21; pfam13276 40041006727 Integrase core domain; Region: rve; pfam00665 40041006728 Integrase core domain; Region: rve_2; pfam13333 40041006729 HMMPfam hit to PF00665, Integrase, catalytic core, score 1.6e-41 40041006730 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 40041006731 Helix-turn-helix domain; Region: HTH_28; pfam13518 40041006732 Helix-turn-helix domain; Region: HTH_28; pfam13518 40041006733 Winged helix-turn helix; Region: HTH_29; pfam13551 40041006734 HMMPfam hit to PF01527, Transposase IS3/IS911, score 6e-07 40041006735 Predicted helix-turn-helix motif with score 1421.000, SD 4.03 at aa 159-180, sequence KDYQAAIEKYGISYQQVYSWVR 40041006736 HMMPfam hit to PF01527, Transposase IS3/IS911, score 1.1e-06 40041006737 ICESz1 40041006738 Probable gene remnant. Similar to the C-terminal region of Peptostreptococcus micros ATCC 33270 uncharacterized protein. UniProt:A8SKT5 (EMBL:ABEE02000016) (282 aa) fasta scores: E()=4.5e-23, 74.2% id in 89 aa 40041006739 Probable gene remnant. Similar to an internal region of Fusobacterium nucleatum subsp. vincentii ATCC 49256 fnv1624 uncharacterized protein fnv1624. UniProt:Q7P2Z0 (EMBL:AABF01000017) (277 aa) fasta scores: E()=5.7e-10, 81.6% id in 38 aa 40041006740 Probable gene remnant. Similar to the N-terminal region of Peptostreptococcus micros ATCC 33270 uncharacterized protein. UniProt:A8SL26 (EMBL:ABEE02000016) (1221 aa) fasta scores: E()=4.2e-12, 71.2% id in 59 aa 40041006741 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 40041006742 non-specific DNA binding site [nucleotide binding]; other site 40041006743 salt bridge; other site 40041006744 sequence-specific DNA binding site [nucleotide binding]; other site 40041006745 Predicted helix-turn-helix motif with score 1436.000, SD 4.08 at aa 17-38, sequence MKKKDLIGKTGISPTTVSKMVK 40041006746 Probable gene remnant. Similar to the C-terminal region of Clostridium difficile (strain 630) conjugative transposon DNA recombination protein UniProt:Q187H3 (EMBL:AM180355) (3011 aa) fasta scores: E()=0, 89.315% id in 730 aa 40041006747 HMMPfam hit to PF00271, DNA/RNA helicase, C-terminal, score 4.9e-05 40041006748 Probable gene remnant. Similar to the N-terminal region of Clostridium difficile (strain 630) conjugative transposon DNA recombination protein UniProt:Q187H3 (EMBL:AM180355) (3011 aa) fasta scores: E()=3e-133, 80.178% id in 449 aa 40041006749 Ortholog of S. equi 4047 (FM204883) SEQ0751; CDS contains a nonsense mutation (ochre) after codon 10. Similar to Fusobacterium nucleatum subsp. polymorphum ATCC 10953 possible transcriptional regulator. UniProt:A5TT90 (EMBL:CM000440) (475 aa) fasta scores: E()=8.9e-141, 73.474% id in 475 aa 40041006750 Predicted helix-turn-helix motif with score 1839.000, SD 5.45 at aa 360-381, sequence ITRKAIAAEAGVSVKTIERAIK 40041006751 HMMPfam hit to PF04326, ATPase associated with various cellular activities, AAA-4, score 9.1e-09 40041006752 Regulators of stationary/sporulation gene expression [Transcription]; Region: AbrB; COG2002 40041006753 SpoVT / AbrB like domain; Region: SpoVT_AbrB; smart00966 40041006754 HMMPfam hit to PF04014, SpoVT/AbrB-like, predicted transcription regulator, score 2.8e-07 40041006755 Probable gene remnant. Similar to the C-terminal region of Clostridium difficile (strain 630) dna topoisomerase. UniProt:Q188K6 (EMBL:AM180355) (568 aa) fasta scores: E()=1.2e-132, 91.7% id in 373 aa 40041006756 HMMPfam hit to PF01131, DNA topoisomerase, type IA, central, score 2.2e-61 40041006757 Probable gene remnant. Similar to the N-terminal region of Clostridium difficile (strain 630) replication initiation protein. UniProt:Q188J3 (EMBL:AM180355) (259 aa) fasta scores: E()=2e-33, 95.3% id in 86 aa 40041006758 HMMPfam hit to PF06970, Replication initiator A, N-terminal, score 3.8e-30 40041006759 3 probable transmembrane helices predicted for SZO12680 by TMHMM2.0 at aa 7-29, 33-50 and 62-84 40041006760 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 40041006761 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338 40041006762 catalytic residues [active] 40041006763 catalytic nucleophile [active] 40041006764 Recombinase; Region: Recombinase; pfam07508 40041006765 Recombinase zinc beta ribbon domain; Region: Zn_ribbon_recom; pfam13408 40041006766 HMMPfam hit to PF07508, Recombinase, score 1.5e-37 40041006767 HMMPfam hit to PF00239, Resolvase, N-terminal, score 5.6e-50 40041006768 DNA-directed RNA polymerase specialized sigma subunit [Transcription]; Region: FliA; COG1191 40041006769 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 40041006770 Radical SAM superfamily; Region: Radical_SAM; pfam04055 40041006771 FeS/SAM binding site; other site 40041006772 HMMPfam hit to PF04055, Radical SAM, score 1.4e-13 40041006773 Protein of unknown function (DUF1706); Region: DUF1706; pfam08020 40041006774 HMMPfam hit to PF08020, Protein of unknown function DUF1706, score 2.6e-45 40041006775 Putative zinc ribbon domain; Region: Zn_ribbon_2; pfam12674 40041006776 Predicted transcriptional regulator [Transcription]; Region: COG2378 40041006777 HTH domain; Region: HTH_11; pfam08279 40041006778 WYL domain; Region: WYL; pfam13280 40041006779 HMMPfam hit to PF08279, Helix-turn-helix, type 11, score 5e-21 40041006780 Predicted helix-turn-helix motif with score 1771.000, SD 5.22 at aa 19-40, sequence VTASELADKFEVSVRTIYRDID 40041006781 Relaxase/Mobilisation nuclease domain; Region: Relaxase; pfam03432 40041006782 HMMPfam hit to PF03432, Endonuclease relaxase, MobA/VirD2, score 1.3e-40 40041006783 Protein of unknown function (DUF2958); Region: DUF2958; pfam11171 40041006784 Type I restriction-modification system methyltransferase subunit [Defense mechanisms]; Region: HsdM; COG0286 40041006785 Methyltransferase domain; Region: Methyltransf_26; pfam13659 40041006786 DNA methylase [Transcription / DNA replication, recombination, and repair]; Region: COG4646 40041006787 DEAD-like helicases superfamily; Region: DEXDc; smart00487 40041006788 DNA methylase [Transcription / DNA replication, recombination, and repair]; Region: COG4646 40041006789 helicase superfamily c-terminal domain; Region: HELICc; smart00490 40041006790 nucleotide binding region [chemical binding]; other site 40041006791 ATP-binding site [chemical binding]; other site 40041006792 TATA element modulatory factor 1 TATA binding; Region: TMF_TATA_bd; pfam12325 40041006793 HMMPfam hit to PF00271, DNA/RNA helicase, C-terminal, score 4.9e-05 40041006794 PS00017 ATP/GTP-binding site motif A (P-loop). 40041006795 Predicted transcriptional regulator containing an HTH domain and an uncharacterized domain shared with the mammalian protein Schlafen [Transcription]; Region: COG2865 40041006796 Divergent AAA domain; Region: AAA_4; pfam04326 40041006797 ATP-dependent DNA helicase recG C-terminal; Region: HATPase_c_4; pfam13749 40041006798 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 40041006799 DNA-binding interface [nucleotide binding]; DNA binding site 40041006800 PS00042 Bacterial regulatory proteins, crp family signature. 40041006801 Predicted helix-turn-helix motif with score 2026.000, SD 6.09 at aa 431-452, sequence VSRKDIAMVLGVSEKTITRYIK 40041006802 HMMPfam hit to PF04326, ATPase associated with various cellular activities, AAA-4, score 1.2e-22 40041006803 Regulators of stationary/sporulation gene expression [Transcription]; Region: AbrB; COG2002 40041006804 SpoVT / AbrB like domain; Region: SpoVT_AbrB; smart00966 40041006805 HMMPfam hit to PF04014, SpoVT/AbrB-like, predicted transcription regulator, score 1.8e-06 40041006806 DNA topoisomerase III, bacteria and conjugative plasmid; Region: topB; TIGR01056 40041006807 TOPRIM_TopoIA_TopoIII: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to topoisomerase III. Type IA DNA topoisomerases remove (relax) negative supercoils in the DNA by: cleaving...; Region: TOPRIM_TopoIA_TopoIII; cd03362 40041006808 active site 40041006809 putative interdomain interaction site [polypeptide binding]; other site 40041006810 putative metal-binding site [ion binding]; other site 40041006811 putative nucleotide binding site [chemical binding]; other site 40041006812 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 40041006813 domain I; other site 40041006814 DNA binding groove [nucleotide binding] 40041006815 phosphate binding site [ion binding]; other site 40041006816 domain II; other site 40041006817 domain III; other site 40041006818 nucleotide binding site [chemical binding]; other site 40041006819 catalytic site [active] 40041006820 domain IV; other site 40041006821 HMMPfam hit to PF01131, DNA topoisomerase, type IA, central, score 2.1e-89 40041006822 PS00396 Prokaryotic DNA topoisomerase I active site. 40041006823 HMMPfam hit to PF01751, TOPRIM, score 1.8e-21 40041006824 Domain of unknown function (DUF4366); Region: DUF4366; pfam14283 40041006825 2 probable transmembrane helices predicted for SZO12830 by TMHMM2.0 at aa 7-29 and 443-465 40041006826 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 40041006827 NlpC/P60 family; Region: NLPC_P60; cl17555 40041006828 1 probable transmembrane helix predicted for SZO12850 by TMHMM2.0 at aa 360-382 40041006829 AAA-like domain; Region: AAA_10; pfam12846 40041006830 Domain of unknown function DUF87; Region: DUF87; pfam01935 40041006831 Predicted helix-turn-helix motif with score 1329.000, SD 3.71 at aa 736-757, sequence GDREILARKLKISLPQLRYVTN 40041006832 PS00017 ATP/GTP-binding site motif A (P-loop). 40041006833 PrgI family protein; Region: PrgI; pfam12666 40041006834 2 probable transmembrane helices predicted for SZO12870 by TMHMM2.0 at aa 21-43 and 47-69 40041006835 1 probable transmembrane helix predicted for SZO12880 by TMHMM2.0 at aa 7-24 40041006836 5 probable transmembrane helices predicted for SZO12890 by TMHMM2.0 at aa 64-86, 107-124, 167-189, 225-247 and 262-284 40041006837 CDS contains a nonsense mutation (amber) after codon 196. Similar to Enterococcus faecalis (Streptococcus faecalis). Enterococcus faecalis (Streptococcus faecalis) group ii intron reverse transcriptase maturase. group ii intron reverse transcriptase maturase. UniProt:Q832B4 (EMBL:AE016830) (628 aa) fasta scores: E()=8.5e-166, 61.699% id in 624 aa 40041006838 HMMPfam hit to PF01844, HNH endonuclease, score 9.7e-10 40041006839 HMMPfam hit to PF00078, RNA-directed DNA polymerase (reverse transcriptase), score 7.7e-24 40041006840 HMMPfam hit to PF00078, RNA-directed DNA polymerase (reverse transcriptase), score 6.6e-26 40041006841 Replication protein A, class 2b aminoacyl-tRNA synthetases, and related proteins with oligonucleotide/oligosaccharide (OB) fold; Region: RPA_2b-aaRSs_OBF_like; cl09930 40041006842 generic binding surface II; other site 40041006843 generic binding surface I; other site 40041006844 FeS assembly ATPase SufC; Region: sufC; TIGR01978 40041006845 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 40041006846 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 40041006847 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 40041006848 HMMPfam hit to PF00005, ABC transporter related, score 3.6e-30 40041006849 PS00017 ATP/GTP-binding site motif A (P-loop). 40041006850 HMMPfam hit to PF00005, ABC transporter related, score 2.5e-25 40041006851 PS00211 ABC transporters family signature. 40041006852 PS00017 ATP/GTP-binding site motif A (P-loop). 40041006853 CDS contains a frameshift after codon 164 due a small deletion. Similar to Clostridium difficile (strain 630) conjugal transfer protein. UniProt:Q188K0 (EMBL:AM180355) (594 aa) fasta scores: E()=0, 95.110% id in 593 aa 40041006854 HMMPfam hit to PF02534, TRAG protein, score 2.7e-17 40041006855 2 probable transmembrane helices predicted for SZO12950 by TMHMM2.0 at aa 25-47 and 73-90 40041006856 Protein of unknown function (DUF3801); Region: DUF3801; pfam12687 40041006857 hypothetical protein; Validated; Region: PRK08116 40041006858 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 40041006859 Walker A motif; other site 40041006860 ATP binding site [chemical binding]; other site 40041006861 Walker B motif; other site 40041006862 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 40041006863 PS00017 ATP/GTP-binding site motif A (P-loop). 40041006864 PS00190 Cytochrome c family heme-binding site signature. 40041006865 Replication initiator protein A (RepA) N-terminus; Region: RepA_N; pfam06970 40041006866 HMMPfam hit to PF06970, Replication initiator A, N-terminal, score 5.6e-36 40041006867 SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase [Translation, ribosomal structure and biogenesis]; Region: TrmA; COG2265 40041006868 TRAM domain; Region: TRAM; pfam01938 40041006869 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 40041006870 S-adenosylmethionine binding site [chemical binding]; other site 40041006871 HMMPfam hit to PF05958, (Uracil-5)-methyltransferase, score 9.3e-07 40041006872 HMMPfam hit to PF01938, Deoxyribonuclease/rho motif-related TRAM, score 2.4e-08 40041006873 Transcriptional regulator [Transcription]; Region: LytR; COG1316 40041006874 HMMPfam hit to PF03816, Cell envelope-related transcriptional attenuator, score 2.6e-79 40041006875 1 probable transmembrane helix predicted for SZO13000 by TMHMM2.0 at aa 148-167 40041006876 shikimate kinase; Reviewed; Region: aroK; PRK00131 40041006877 Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464 40041006878 ADP binding site [chemical binding]; other site 40041006879 magnesium binding site [ion binding]; other site 40041006880 putative shikimate binding site; other site 40041006881 HMMPfam hit to PF01202, Shikimate kinase, score 3.9e-54 40041006882 PS01128 Shikimate kinase signature. 40041006883 PS00017 ATP/GTP-binding site motif A (P-loop). 40041006884 3-phosphoshikimate 1-carboxyvinyltransferase; Provisional; Region: PRK02427 40041006885 EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556 40041006886 hinge; other site 40041006887 active site 40041006888 HMMPfam hit to PF00275, 3-phosphoshikimate 1-carboxyvinyltransferase, score 8.1e-135 40041006889 PS00017 ATP/GTP-binding site motif A (P-loop). 40041006890 PS00104 EPSP synthase signature 1. 40041006891 Ribonuclease BN family enzyme [Replication, recombination, and repair]; Region: Rbn; COG1295 40041006892 HMMPfam hit to PF03631, Ribonuclease BN, score 8.9e-82 40041006893 6 probable transmembrane helices predicted for SZO13030 by TMHMM2.0 at aa 35-57, 86-108, 138-160, 181-203, 216-238 and 250-272 40041006894 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 40041006895 active site 40041006896 HMMPfam hit to PF00557, Peptidase M24, catalytic core, score 4e-44 40041006897 Predicted transcriptional regulator containing CBS domains [Transcription]; Region: COG4109 40041006898 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 40041006899 DNA-binding site [nucleotide binding]; DNA binding site 40041006900 DRTGG domain; Region: DRTGG; pfam07085 40041006901 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with a DRTGG domain upstream. The function of the DRTGG domain, named after its conserved residues, is unknown. CBS is a small domain originally...; Region: CBS_pair_DRTGG_assoc; cd04596 40041006902 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cd03440 40041006903 active site 2 [active] 40041006904 active site 1 [active] 40041006905 HMMPfam hit to PF03061, Thioesterase superfamily, score 0.00013 40041006906 HMMPfam hit to PF00571, Cystathionine beta-synthase, core, score 1.7e-24 40041006907 HMMPfam hit to PF07085, DRTGG, score 2.1e-53 40041006908 HMMPfam hit to PF00392, Bacterial regulatory protein GntR, HTH, score 0.0034 40041006909 Predicted helix-turn-helix motif with score 1136.000, SD 3.06 at aa 20-41, sequence VSVRSISNHLKVSDGTAYRAIK 40041006910 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 40041006911 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 40041006912 HMMPfam hit to PF00583, GCN5-related N-acetyltransferase, score 2.9e-10 40041006913 YSIRK type signal peptide; Region: YSIRK_signal; cl04650 40041006914 GA module; Region: GA; pfam01468 40041006915 B domain; Region: IgG_binding_B; pfam01378 40041006916 B domain; Region: IgG_binding_B; pfam01378 40041006917 HMMPfam hit to PF00746, Surface protein from Gram-positive cocci, anchor region, score 1e-12 40041006918 PS00343 Gram-positive cocci surface proteins 'anchoring' hexapeptide. 40041006919 HMMPfam hit to PF01378, IgG-binding B, score 4.9e-34 40041006920 HMMPfam hit to PF01378, IgG-binding B, score 3.3e-29 40041006921 HMMPfam hit to PF01468, Protein G-related, albumin-binding GA module, score 7.3e-17 40041006922 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 40041006923 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; cl07971 40041006924 HMMPfam hit to PF00933, Glycoside hydrolase, family 3, N-terminal, score 9.6e-26 40041006925 haloacid dehalogenase-like hydrolase; Region: Hydrolase; pfam00702 40041006926 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 40041006927 motif II; other site 40041006928 HMMPfam hit to PF00702, Haloacid dehalogenase-like hydrolase, score 5.9e-09 40041006929 D-mannonate oxidoreductase; Provisional; Region: PRK08277 40041006930 putative D-mannonate oxidoreductase, classical (c) SDR; Region: mannonate_red_SDR_c; cd08935 40041006931 putative NAD(P) binding site [chemical binding]; other site 40041006932 active site 40041006933 HMMPfam hit to PF00106, Short-chain dehydrogenase/reductase SDR, score 6.5e-14 40041006934 PS00061 Short-chain dehydrogenases/reductases family signature. 40041006935 mannonate dehydratase; Provisional; Region: PRK03906 40041006936 mannonate dehydratase; Region: uxuA; TIGR00695 40041006937 HMMPfam hit to PF03786, Mannonate dehydratase, score 1e-191 40041006938 Glucuronate isomerase; Region: UxaC; pfam02614 40041006939 Glucuronate isomerase [Carbohydrate transport and metabolism]; Region: UxaC; COG1904 40041006940 HMMPfam hit to PF02614, Glucuronate isomerase, score 3.7e-163 40041006941 2-keto-3-deoxy-6-phosphogluconate aldolase [Carbohydrate transport and metabolism]; Region: Eda; COG0800 40041006942 KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452 40041006943 active site 40041006944 intersubunit interface [polypeptide binding]; other site 40041006945 catalytic residue [active] 40041006946 HMMPfam hit to PF01081, KDPG and KHG aldolase, score 9.6e-33 40041006947 Transcriptional regulators [Transcription]; Region: FadR; COG2186 40041006948 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 40041006949 DNA-binding site [nucleotide binding]; DNA binding site 40041006950 FCD domain; Region: FCD; pfam07729 40041006951 HMMPfam hit to PF07729, GntR, C-terminal, score 9.8e-32 40041006952 HMMPfam hit to PF00392, Bacterial regulatory protein GntR, HTH, score 3.3e-20 40041006953 PS00043 Bacterial regulatory proteins, gntR family signature. 40041006954 Predicted helix-turn-helix motif with score 1121.000, SD 3.00 at aa 29-50, sequence PNEYELAQDLEVGRSTIREAVR 40041006955 beta-D-glucuronidase; Provisional; Region: PRK10150 40041006956 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837 40041006957 Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703 40041006958 Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836 40041006959 HMMPfam hit to PF02836, Glycoside hydrolase family 2, TIM barrel, score 5.5e-94 40041006960 PS00719 Glycosyl hydrolases family 2 signature 1. 40041006961 HMMPfam hit to PF00703, Glycoside hydrolase family 2, immunoglobulin-like beta-sandwich, score 3.7e-16 40041006962 HMMPfam hit to PF02837, Glycoside hydrolase family 2, carbohydrate-binding, score 8.9e-43 40041006963 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 40041006964 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166 40041006965 substrate binding site [chemical binding]; other site 40041006966 ATP binding site [chemical binding]; other site 40041006967 HMMPfam hit to PF00294, Carbohydrate/purine kinase, score 2.5e-19 40041006968 MFS/sugar transport protein; Region: MFS_2; pfam13347 40041006969 melibiose:sodium symporter; Provisional; Region: PRK10429; cl15392 40041006970 11 probable transmembrane helices predicted for SZO13170 by TMHMM2.0 at aa 34-56, 91-113, 117-134, 155-177, 192-214, 255-277, 287-306, 313-335, 345-364, 404-426 and 441-463 40041006971 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 40041006972 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 40041006973 hinge; other site 40041006974 active site 40041006975 HMMPfam hit to PF00275, 3-phosphoshikimate 1-carboxyvinyltransferase, score 2.8e-106 40041006976 PS00017 ATP/GTP-binding site motif A (P-loop). 40041006977 PS00017 ATP/GTP-binding site motif A (P-loop). 40041006978 S-adenosylmethionine synthetase; Validated; Region: PRK05250 40041006979 S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438 40041006980 S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772 40041006981 S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773 40041006982 HMMPfam hit to PF02773, S-adenosylmethionine synthetase, score 7.2e-88 40041006983 PS00377 S-adenosylmethionine synthetase signature 2. 40041006984 HMMPfam hit to PF02772, S-adenosylmethionine synthetase, score 4e-78 40041006985 PS00376 S-adenosylmethionine synthetase signature 1. 40041006986 HMMPfam hit to PF00438, S-adenosylmethionine synthetase, score 1.2e-48 40041006987 streptococcal histidine triad protein; Region: strep_his_triad; TIGR01363 40041006988 Streptococcal histidine triad protein; Region: Strep_his_triad; pfam04270 40041006989 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 40041006990 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 40041006991 Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond...; Region: LRR_RI; cl15309 40041006992 Substrate binding site [chemical binding]; other site 40041006993 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 40041006994 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 40041006995 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 40041006996 HMMPfam hit to PF00560, Leucine-rich repeat, score 2.1 40041006997 HMMPfam hit to PF04270, Streptococcal histidine triad, score 15 40041006998 HMMPfam hit to PF04270, Streptococcal histidine triad, score 0.03 40041006999 HMMPfam hit to PF04270, Streptococcal histidine triad, score 0.00026 40041007000 HMMPfam hit to PF04270, Streptococcal histidine triad, score 0.034 40041007001 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 40041007002 bifunctional biotin--[acetyl-CoA-carboxylase] synthetase/biotin operon repressor; Provisional; Region: PRK11886 40041007003 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 40041007004 putative DNA binding site [nucleotide binding]; other site 40041007005 putative Zn2+ binding site [ion binding]; other site 40041007006 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; pfam03099 40041007007 Biotin protein ligase C terminal domain; Region: BPL_C; pfam02237 40041007008 HMMPfam hit to PF08279, Helix-turn-helix, type 11, score 1.3e-14 40041007009 Predicted helix-turn-helix motif with score 1273.000, SD 3.52 at aa 18-39, sequence VSGEHLAEQLKLSRTSVWKSIK 40041007010 HMMPfam hit to PF03099, Biotin/lipoate A/B protein ligase, score 3.4e-05 40041007011 HMMPfam hit to PF02237, Biotin protein ligase, C-terminal, score 6.7e-09 40041007012 DNA polymerase III subunits gamma and tau; Validated; Region: PRK05563 40041007013 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 40041007014 Walker A motif; other site 40041007015 ATP binding site [chemical binding]; other site 40041007016 Walker B motif; other site 40041007017 arginine finger; other site 40041007018 DNA polymerase III subunits gamma and tau domain III; Region: DNA_pol3_gamma3; pfam12169 40041007019 HMMPfam hit to PF00004, AAA ATPase, core, score 4.1e-11 40041007020 PS00017 ATP/GTP-binding site motif A (P-loop). 40041007021 GAF domain-containing protein [Signal transduction mechanisms]; Region: COG1956 40041007022 HMMPfam hit to PF01590, GAF, score 9.5e-06 40041007023 Protease prsW family; Region: PrsW-protease; pfam13367 40041007024 6 probable transmembrane helices predicted for SZO13240 by TMHMM2.0 at aa 9-31, 41-63, 75-97, 117-139, 191-208 and 237-259 40041007025 Predicted membrane protein [Function unknown]; Region: COG3326 40041007026 3 probable transmembrane helices predicted for SZO13250 by TMHMM2.0 at aa 13-32, 47-69 and 76-98 40041007027 HMMPfam hit to PF06961, Protein of unknown function DUF1294, score 7.7e-29 40041007028 Uridine kinase [Nucleotide transport and metabolism]; Region: Udk; COG0572 40041007029 Uridine monophosphate kinase (UMPK, EC 2.7.1.48), also known as uridine kinase or uridine-cytidine kinase (UCK), catalyzes the reversible phosphoryl transfer from ATP to uridine or cytidine to yield UMP or CMP. In the primidine nucleotide-salvage pathway; Region: UMPK; cd02023 40041007030 Sugar specificity; other site 40041007031 Pyrimidine base specificity; other site 40041007032 ATP-binding site [chemical binding]; other site 40041007033 HMMPfam hit to PF00485, Phosphoribulokinase/uridine kinase, score 3.7e-54 40041007034 PS00017 ATP/GTP-binding site motif A (P-loop). 40041007035 Superfamily II DNA and RNA helicases [DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis]; Region: SrmB; COG0513 40041007036 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 40041007037 ATP binding site [chemical binding]; other site 40041007038 putative Mg++ binding site [ion binding]; other site 40041007039 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 40041007040 nucleotide binding region [chemical binding]; other site 40041007041 ATP-binding site [chemical binding]; other site 40041007042 HMMPfam hit to PF00270, DNA/RNA helicase, DEAD/DEAH box type, N-terminal, score 9.2e-39 40041007043 HMMPfam hit to PF00271, DNA/RNA helicase, C-terminal, score 1.4e-26 40041007044 delta-lactam-biosynthetic de-N-acetylase; Region: spore_pdaA; TIGR02884 40041007045 Catalytic NodB homology domain of Streptococcus pneumoniae peptidoglycan deacetylase PgdA, Bacillus subtilis BsYjeA protein, and their bacterial homologs; Region: CE4_SpPgdA_BsYjeA_like; cd10947 40041007046 NodB motif; other site 40041007047 active site 40041007048 catalytic site [active] 40041007049 Zn binding site [ion binding]; other site 40041007050 HMMPfam hit to PF01522, Polysaccharide deacetylase, score 2.9e-52 40041007051 1 probable transmembrane helix predicted for SZO13280 by TMHMM2.0 at aa 5-27 40041007052 DNA/RNA non-specific endonuclease; Region: Endonuclea_NS_2; cl17626 40041007053 DNA/RNA non-specific endonuclease; Region: Endonuclease_NS; smart00892 40041007054 HMMPfam hit to PF01223, DNA/RNA non-specific endonuclease, score 1.8e-31 40041007055 alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252 40041007056 Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673 40041007057 motif 1; other site 40041007058 active site 40041007059 motif 2; other site 40041007060 motif 3; other site 40041007061 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 40041007062 DHHA1 domain; Region: DHHA1; pfam02272 40041007063 HMMPfam hit to PF02272, Phosphoesterase, DHHA1, score 4.9e-15 40041007064 HMMPfam hit to PF07973, Threonyl/alanyl tRNA synthetase, SAD, score 5.9e-23 40041007065 HMMPfam hit to PF01411, Alanyl-tRNA synthetase, class IIc, score 5.2e-259 40041007066 PS00339 Aminoacyl-transfer RNA synthetases class-II signature 2. 40041007067 foldase protein PrsA; Reviewed; Region: PRK12450 40041007068 PPIC-type PPIASE domain; Region: Rotamase_2; pfam13145 40041007069 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 40041007070 Predicted O-methyltransferase [General function prediction only]; Region: COG4122 40041007071 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 40041007072 S-adenosylmethionine binding site [chemical binding]; other site 40041007073 HMMPfam hit to PF08241, Methyltransferase type 11, score 4.5e-09 40041007074 beta-phosphoglucomutase family hydrolase; Region: PGMB-YQAB-SF; TIGR02009 40041007075 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 40041007076 motif II; other site 40041007077 HMMPfam hit to PF00702, Haloacid dehalogenase-like hydrolase, score 3.8e-25 40041007078 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 40041007079 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 40041007080 motif II; other site 40041007081 HMMPfam hit to PF00702, Haloacid dehalogenase-like hydrolase, score 2.5e-21 40041007082 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 40041007083 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 40041007084 Coenzyme A binding pocket [chemical binding]; other site 40041007085 HMMPfam hit to PF00583, GCN5-related N-acetyltransferase, score 1.1e-11 40041007086 Oligoendopeptidase F [Amino acid transport and metabolism]; Region: COG1164 40041007087 Peptidase family M3B Oligopeptidase F (PepF); Region: M3B_PepF_3; cd09608 40041007088 active site 40041007089 Zn binding site [ion binding]; other site 40041007090 HMMPfam hit to PF01432, Peptidase M3A and M3B, thimet/oligopeptidase F, score 2.9e-149 40041007091 HMMPfam hit to PF08439, Peptidase M3B, oligopeptidase F, N-terminal, score 1.7e-25 40041007092 Competence protein CoiA-like family; Region: CoiA; cl11541 40041007093 HMMPfam hit to PF06054, Competence CoiA-like, score 4.8e-115 40041007094 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 40041007095 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 40041007096 RNA binding surface [nucleotide binding]; other site 40041007097 Pseudouridine synthase, Escherichia coli RsuA like; Region: PseudoU_synth_RsuA; cd02553 40041007098 active site 40041007099 uracil binding [chemical binding]; other site 40041007100 HMMPfam hit to PF00849, Pseudouridine synthase, score 7.3e-15 40041007101 PS01149 Rsu family of pseudouridine synthase signature. 40041007102 HMMPfam hit to PF01479, RNA-binding S4, score 2.3e-07 40041007103 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363 40041007104 GlcN6P_deaminase: Glucosamine-6-phosphate (GlcN6P) deaminase subfamily; GlcN6P deaminase catalyzes the reversible conversion of GlcN6P to D-fructose-6-phosphate (Fru6P) and ammonium. The reaction is an aldo-keto isomerization coupled with an amination or...; Region: GlcN6P_deaminase; cd01399 40041007105 active site 40041007106 trimer interface [polypeptide binding]; other site 40041007107 allosteric site; other site 40041007108 active site lid [active] 40041007109 hexamer (dimer of trimers) interface [polypeptide binding]; other site 40041007110 HMMPfam hit to PF01182, Glucosamine/galactosamine-6-phosphate isomerase, score 3.5e-40 40041007111 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Provisional; Region: queA; PRK00147 40041007112 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Region: queA; TIGR00113 40041007113 HMMPfam hit to PF02547, Queuosine biosynthesis protein, score 1.5e-116 40041007114 Protein of unknown function (DUF3114); Region: DUF3114; pfam11311 40041007115 Transglutaminase-like superfamily; Region: Transglut_core; cl17362 40041007116 PS00881 Protein splicing signature. 40041007117 1 probable transmembrane helix predicted for SZO13420 by TMHMM2.0 at aa 21-43 40041007118 Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605 40041007119 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 40041007120 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 40041007121 HMMPfam hit to PF02777, Manganese and iron superoxide dismutase, score 7.2e-71 40041007122 PS00088 Manganese and iron superoxide dismutases signature. 40041007123 HMMPfam hit to PF00081, Manganese and iron superoxide dismutase, score 2.1e-43 40041007124 DNA polymerase III subunit delta; Reviewed; Region: holA; PRK05574 40041007125 DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144 40041007126 HMMPfam hit to PF06144, DNA polymerase III, delta, score 7.5e-113 40041007127 Predicted membrane metal-binding protein [General function prediction only]; Region: ComEC; COG0658 40041007128 Domain of unknown function (DUF4131); Region: DUF4131; pfam13567 40041007129 Competence protein; Region: Competence; pfam03772 40041007130 Predicted hydrolase (metallo-beta-lactamase superfamily) [General function prediction only]; Region: ComEC; COG2333 40041007131 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 40041007132 HMMPfam hit to PF00753, Beta-lactamase-like, score 2.6e-14 40041007133 7 probable transmembrane helices predicted for SZO13450 by TMHMM2.0 at aa 5-27, 32-51, 319-341, 370-392, 399-421, 436-458 and 465-487 40041007134 HMMPfam hit to PF03772, ComEC/Rec2-related protein, score 3.1e-38 40041007135 SLBB domain; Region: SLBB; pfam10531 40041007136 comEA protein; Region: comE; TIGR01259 40041007137 RelA- and SpoT-like ppGpp Synthetases and Hydrolases, catalytic domain; Region: Rel-Spo_like; cl11966 40041007138 HMMPfam hit to PF00633, Helix-hairpin-helix motif, score 1.2e-06 40041007139 1 probable transmembrane helix predicted for SZO13460 by TMHMM2.0 at aa 17-39 40041007140 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 40041007141 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 40041007142 putative acyl-acceptor binding pocket; other site 40041007143 2 probable transmembrane helices predicted for SZO13470 by TMHMM2.0 at aa 12-34 and 228-250 40041007144 HMMPfam hit to PF01553, Phospholipid/glycerol acyltransferase, score 9.3e-23 40041007145 Predicted O-methyltransferase [General function prediction only]; Region: COG4123 40041007146 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 40041007147 S-adenosylmethionine binding site [chemical binding]; other site 40041007148 HMMPfam hit to PF05175, Methyltransferase small, score 1.8e-06 40041007149 PS00092 N-6 Adenine-specific DNA methylases signature. 40041007150 The GIY-YIG domain of uncharacterized protein family UPF0213 related to structure-specific endonuclease SLX1; Region: GIY-YIG_UPF0213; cd10456 40041007151 GIY-YIG motif/motif A; other site 40041007152 putative active site [active] 40041007153 putative metal binding site [ion binding]; other site 40041007154 HMMPfam hit to PF01541, Excinuclease ABC, C subunit, N-terminal, score 7.1e-23 40041007155 K+ potassium transporter; Region: K_trans; cl15781 40041007156 HMMPfam hit to PF02705, K+ potassium transporter, score 6.6e-37 40041007157 12 probable transmembrane helices predicted for SZO13500 by TMHMM2.0 at aa 12-34, 54-76, 103-125, 140-162, 169-191, 220-242, 249-271, 291-313, 334-356, 371-393, 400-422 and 426-448 40041007158 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 40041007159 ATP-dependent RNA helicase SrmB; Provisional; Region: PRK11192 40041007160 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 40041007161 ATP binding site [chemical binding]; other site 40041007162 Mg++ binding site [ion binding]; other site 40041007163 motif III; other site 40041007164 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 40041007165 nucleotide binding region [chemical binding]; other site 40041007166 ATP-binding site [chemical binding]; other site 40041007167 HMMPfam hit to PF00271, DNA/RNA helicase, C-terminal, score 1.4e-35 40041007168 HMMPfam hit to PF00270, DNA/RNA helicase, DEAD/DEAH box type, N-terminal, score 1.1e-75 40041007169 PS00039 DEAD-box subfamily ATP-dependent helicases signature. 40041007170 PS00017 ATP/GTP-binding site motif A (P-loop). 40041007171 peptide chain release factor 3; Provisional; Region: prfC; PRK00741 40041007172 Release Factor 3 (RF3) protein involved in the terminal step of translocation in bacteria; Region: RF3; cd04169 40041007173 G1 box; other site 40041007174 putative GEF interaction site [polypeptide binding]; other site 40041007175 GTP/Mg2+ binding site [chemical binding]; other site 40041007176 Switch I region; other site 40041007177 G2 box; other site 40041007178 G3 box; other site 40041007179 Switch II region; other site 40041007180 G4 box; other site 40041007181 G5 box; other site 40041007182 RF3_II: this subfamily represents the domain II of bacterial Release Factor 3 (RF3). Termination of protein synthesis by the ribosome requires two release factor (RF) classes. The class II RF3 is a GTPase that removes class I RFs (RF1 or RF2) from the...; Region: RF3_II; cd03689 40041007183 HMMPfam hit to PF03144, Translation elongation factor EFTu/EF1A, domain 2, score 3.3e-13 40041007184 PS00732 Ribosomal protein S16 signature. 40041007185 HMMPfam hit to PF00009, Protein synthesis factor, GTP-binding, score 1e-66 40041007186 PS00301 GTP-binding elongation factors signature. 40041007187 conserved hypothetical integral membrane protein TIGR02206; Region: intg_mem_TP0381 40041007188 6 probable transmembrane helices predicted for SZO13530 by TMHMM2.0 at aa 11-33, 46-65, 98-117, 124-146, 161-183 and 195-217 40041007189 UDP-N-acetylmuramyl pentapeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurF; COG0770 40041007190 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 40041007191 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 40041007192 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 40041007193 HMMPfam hit to PF02875, Mur ligase, C-terminal, score 5.4e-07 40041007194 HMMPfam hit to PF08245, Mur ligase, central, score 2e-52 40041007195 HMMPfam hit to PF01225, Mur ligase, N-terminal, score 1.2e-11 40041007196 Transposase [DNA replication, recombination, and repair]; Region: COG5421 40041007197 Transposase [DNA replication, recombination, and repair]; Region: COG5421 40041007198 D-alanyl-alanine synthetase A; Reviewed; Region: ddl; PRK01966 40041007199 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 40041007200 ATP-grasp domain; Region: ATP-grasp_4; cl17255 40041007201 HMMPfam hit to PF07478, D-alanine--D-alanine ligase, C-terminal, score 1.1e-92 40041007202 PS00844 D-alanine--D-alanine ligase signature 2. 40041007203 HMMPfam hit to PF01820, D-alanine--D-alanine ligase, N-terminal, score 5.1e-42 40041007204 PS00843 D-alanine--D-alanine ligase signature 1. 40041007205 DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; pfam13808 40041007206 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 40041007207 DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; cl17880 40041007208 HMMPfam hit to PF01609, Transposase, IS4-like, score 6.6e-17 40041007209 recombination protein RecR; Reviewed; Region: recR; PRK00076 40041007210 RecR protein; Region: RecR; pfam02132 40041007211 TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR. RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025 40041007212 putative active site [active] 40041007213 putative metal-binding site [ion binding]; other site 40041007214 tetramer interface [polypeptide binding]; other site 40041007215 HMMPfam hit to PF01751, TOPRIM, score 1.9e-15 40041007216 HMMPfam hit to PF02132, Zinc finger C4-type, RecR, score 7.7e-20 40041007217 PS01300 RecR protein signature. 40041007218 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 40041007219 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 40041007220 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 40041007221 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 40041007222 HMMPfam hit to PF00905, Penicillin-binding protein, transpeptidase, score 3e-84 40041007223 HMMPfam hit to PF03717, Penicillin-binding protein, dimerisation domain, score 5.7e-38 40041007224 1 probable transmembrane helix predicted for SZO13590 by TMHMM2.0 at aa 16-35 40041007225 Formate/nitrite family of transporters [Inorganic ion transport and metabolism]; Region: FocA; COG2116 40041007226 HMMPfam hit to PF01226, Formate/nitrite transporter, score 5.4e-39 40041007227 6 probable transmembrane helices predicted for SZO13600 by TMHMM2.0 at aa 23-45, 60-82, 103-125, 156-178, 191-213 and 223-245 40041007228 PS00213 Lipocalin signature. 40041007229 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 40041007230 PS01005 Formate and nitrite transporters signature 1. 40041007231 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 40041007232 5 probable transmembrane helices predicted for SZO13610 by TMHMM2.0 at aa 10-32, 45-67, 72-94, 107-129 and 144-166 40041007233 Predicted small molecule binding protein (contains 3H domain) [General function prediction only]; Region: COG1827 40041007234 HTH domain; Region: HTH_11; pfam08279 40041007235 3H domain; Region: 3H; pfam02829 40041007236 HMMPfam hit to PF02829, 3H, score 2.8e-24 40041007237 HMMPfam hit to PF08279, Helix-turn-helix, type 11, score 1.2e-15 40041007238 Predicted helix-turn-helix motif with score 1167.000, SD 3.16 at aa 21-42, sequence ISATSLAKALGVSRQVIVGDIA 40041007239 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 40041007240 catalytic core [active] 40041007241 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 40041007242 HMMPfam hit to PF00300, Phosphoglycerate mutase, score 1.9e-44 40041007243 dihydroorotate dehydrogenase (subfamily 1) family protein; Region: pyrD_sub1_fam; TIGR01037 40041007244 Dihydroorotate dehydrogenase (DHOD) class 1A FMN-binding domain. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine...; Region: DHOD_1A_like; cd04741 40041007245 active site 40041007246 FMN binding site [chemical binding]; other site 40041007247 substrate binding site [chemical binding]; other site 40041007248 catalytic residues [active] 40041007249 homodimer interface [polypeptide binding]; other site 40041007250 HMMPfam hit to PF01180, Dihydroorotate dehydrogenase, core, score 1.3e-110 40041007251 PS00912 Dihydroorotate dehydrogenase signature 2. 40041007252 1 probable transmembrane helix predicted for SZO13650 by TMHMM2.0 at aa 4-24 40041007253 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 40041007254 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 40041007255 non-specific DNA binding site [nucleotide binding]; other site 40041007256 salt bridge; other site 40041007257 sequence-specific DNA binding site [nucleotide binding]; other site 40041007258 transcriptional activator, Rgg/GadR/MutR family, C-terminal domain; Region: RGG_Cterm; TIGR01716 40041007259 HMMPfam hit to PF01381, Helix-turn-helix type 3, score 2.8e-07 40041007260 H+ Antiporter protein; Region: 2A0121; TIGR00900 40041007261 HMMPfam hit to PF07690, Major facilitator superfamily MFS-1, score 2.6e-17 40041007262 10 probable transmembrane helices predicted for SZO13670 by TMHMM2.0 at aa 71-90, 94-116, 137-156, 160-182, 218-240, 255-274, 281-300, 304-326, 338-360 and 370-392 40041007263 ADP-ribosyltransferase exoenzyme; Region: ADPrib_exo_Tox; pfam03496 40041007264 active site 40041007265 conformational flexibility of ligand binding pocket; other site 40041007266 ADP-ribosylating toxin turn-turn motif; other site 40041007267 1 probable transmembrane helix predicted for SZO13680 by TMHMM2.0 at aa 15-32 40041007268 HMMPfam hit to PF03496, Clostridial binary exotoxin A, score 8.5e-10 40041007269 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 40041007270 IHF dimer interface [polypeptide binding]; other site 40041007271 IHF - DNA interface [nucleotide binding]; other site 40041007272 HMMPfam hit to PF00216, Histone-like bacterial DNA-binding protein, score 1.1e-51 40041007273 PS00045 Bacterial histone-like DNA-binding proteins signature. 40041007274 Uncharacterized protein conserved in bacteria (DUF2140); Region: DUF2140; cl11548 40041007275 Members of the SGNH-hydrolase superfamily, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase_YpmR_like; cd04506 40041007276 active site 40041007277 catalytic triad [active] 40041007278 oxyanion hole [active] 40041007279 HMMPfam hit to PF00657, Lipolytic enzyme, G-D-S-L, score 4.9e-22 40041007280 1 probable transmembrane helix predicted for SZO13710 by TMHMM2.0 at aa 5-27 40041007281 EDD domain protein, DegV family; Region: DegV; TIGR00762 40041007282 Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645 40041007283 HMMPfam hit to PF02645, DegV, score 2.3e-69 40041007284 PS00343 Gram-positive cocci surface proteins 'anchoring' hexapeptide. 40041007285 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: RecN; COG0497 40041007286 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 40041007287 Walker A/P-loop; other site 40041007288 ATP binding site [chemical binding]; other site 40041007289 Q-loop/lid; other site 40041007290 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 40041007291 Q-loop/lid; other site 40041007292 ABC transporter signature motif; other site 40041007293 Walker B; other site 40041007294 D-loop; other site 40041007295 H-loop/switch region; other site 40041007296 HMMPfam hit to PF02463, SMC protein, N-terminal, score 2.4e-11 40041007297 PS00017 ATP/GTP-binding site motif A (P-loop). 40041007298 Arginine repressor [Transcription]; Region: ArgR; COG1438 40041007299 Arginine repressor, DNA binding domain; Region: Arg_repressor; pfam01316 40041007300 HMMPfam hit to PF02863, Arginine repressor, score 5e-21 40041007301 HMMPfam hit to PF01316, Arginine repressor, score 3.5e-24 40041007302 Predicted rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: COG1189 40041007303 S4 RNA-binding domain; Region: S4; smart00363 40041007304 FtsJ-like methyltransferase; Region: FtsJ; pfam01728 40041007305 HMMPfam hit to PF01728, Ribosomal RNA methyltransferase RrmJ/FtsJ, score 0.00021 40041007306 HMMPfam hit to PF01479, RNA-binding S4, score 0.021 40041007307 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 40041007308 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 40041007309 substrate binding pocket [chemical binding]; other site 40041007310 chain length determination region; other site 40041007311 substrate-Mg2+ binding site; other site 40041007312 catalytic residues [active] 40041007313 aspartate-rich region 1; other site 40041007314 active site lid residues [active] 40041007315 aspartate-rich region 2; other site 40041007316 HMMPfam hit to PF00348, Polyprenyl synthetase, score 6.4e-63 40041007317 PS00444 Polyprenyl synthetases signature 2. 40041007318 PS00723 Polyprenyl synthetases signature 1. 40041007319 exodeoxyribonuclease VII small subunit; Provisional; Region: PRK00977 40041007320 HMMPfam hit to PF02609, Exonuclease VII, small subunit, score 2.7e-29 40041007321 exodeoxyribonuclease VII large subunit; Reviewed; Region: xseA; PRK00286 40041007322 ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489 40041007323 generic binding surface II; other site 40041007324 generic binding surface I; other site 40041007325 HMMPfam hit to PF02601, Exonuclease VII, large subunit, score 8.1e-44 40041007326 HMMPfam hit to PF01336, Nucleic acid binding, OB-fold, tRNA/helicase-type, score 1.4e-14 40041007327 B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171 40041007328 putative substrate binding site [chemical binding]; other site 40041007329 putative ATP binding site [chemical binding]; other site 40041007330 HMMPfam hit to PF01256, Carbohydrate kinase, score 1.3e-69 40041007331 PS01050 Uncharacterized protein family UPF0031 signature 2. 40041007332 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 40041007333 1 probable transmembrane helix predicted for SZO13800 by TMHMM2.0 at aa 24-46 40041007334 bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK14179 40041007335 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763 40041007336 NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080 40041007337 homodimer interface [polypeptide binding]; other site 40041007338 NADP binding site [chemical binding]; other site 40041007339 substrate binding site [chemical binding]; other site 40041007340 HMMPfam hit to PF02882, Tetrahydrofolate dehydrogenase/cyclohydrolase, score 7.2e-111 40041007341 PS00767 Tetrahydrofolate dehydrogenase/cyclohydrolase signature 2. 40041007342 HMMPfam hit to PF00763, Tetrahydrofolate dehydrogenase/cyclohydrolase, score 1.2e-66 40041007343 PS00766 Tetrahydrofolate dehydrogenase/cyclohydrolase signature 1. 40041007344 phosphoglucomutase-2-like protein; Provisional; Region: PTZ00150 40041007345 This CD includes PGM2 (phosphoglucomutase 2) and PGM2L1 (phosphoglucomutase 2-like 1). The mammalian PGM2 is thought to be a phosphopentomutase that catalyzes the conversion of the nucleoside breakdown products, ribose-1-phosphate and...; Region: PGM2; cd05799 40041007346 active site 40041007347 substrate binding site [chemical binding]; other site 40041007348 metal binding site [ion binding]; metal-binding site 40041007349 HMMPfam hit to PF00408, Phosphoglucomutase/phosphomannomutase C-terminal, score 1.9e-05 40041007350 HMMPfam hit to PF02880, Phosphoglucomutase/phosphomannomutase alpha/beta/alpha domain III, score 0.0027 40041007351 HMMPfam hit to PF02879, Phosphoglucomutase/phosphomannomutase alpha/beta/alpha domain II, score 0.0036 40041007352 HMMPfam hit to PF02878, Phosphoglucomutase/phosphomannomutase alpha/beta/alpha domain I, score 6.4e-59 40041007353 PS00710 Phosphoglucomutase and phosphomannomutase phosphoserine signature. 40041007354 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 40041007355 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 40041007356 Walker A/P-loop; other site 40041007357 ATP binding site [chemical binding]; other site 40041007358 Q-loop/lid; other site 40041007359 ABC transporter signature motif; other site 40041007360 Walker B; other site 40041007361 D-loop; other site 40041007362 H-loop/switch region; other site 40041007363 HMMPfam hit to PF00005, ABC transporter related, score 4.8e-70 40041007364 PS00211 ABC transporters family signature. 40041007365 PS00017 ATP/GTP-binding site motif A (P-loop). 40041007366 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 40041007367 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 40041007368 dimer interface [polypeptide binding]; other site 40041007369 conserved gate region; other site 40041007370 putative PBP binding loops; other site 40041007371 ABC-ATPase subunit interface; other site 40041007372 HMMPfam hit to PF00528, Binding-protein-dependent transport systems inner membrane component, score 2.5e-27 40041007373 3 probable transmembrane helices predicted for SZO13840 by TMHMM2.0 at aa 15-37, 50-72 and 194-216 40041007374 PS00402 Binding-protein-dependent transport systems inner membrane comp. sign. 40041007375 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 40041007376 Collagen triple helix repeat (20 copies); Region: Collagen; pfam01391 40041007377 Gram positive anchor; Region: Gram_pos_anchor; pfam00746 40041007378 HMMPfam hit to PF01391, Collagen triple helix repeat, score 1e-14 40041007379 HMMPfam hit to PF01391, Collagen triple helix repeat, score 6.9e-14 40041007380 HMMPfam hit to PF00746, Surface protein from Gram-positive cocci, anchor region, score 6.2e-12 40041007381 PS00343 Gram-positive cocci surface proteins 'anchoring' hexapeptide. 40041007382 Protein of unknown function (DUF1797); Region: DUF1797; cl11550 40041007383 HMMPfam hit to PF08796, Protein of unknown function DUF1797, score 1.1e-36 40041007384 ATP-binding subunits of Clp protease and DnaK/DnaJ chaperones [Posttranslational modification, protein turnover, chaperones]; Region: clpA; COG0542 40041007385 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 40041007386 Walker A motif; other site 40041007387 ATP binding site [chemical binding]; other site 40041007388 Walker B motif; other site 40041007389 arginine finger; other site 40041007390 UvrB/uvrC motif; Region: UVR; pfam02151 40041007391 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 40041007392 Walker A motif; other site 40041007393 ATP binding site [chemical binding]; other site 40041007394 Walker B motif; other site 40041007395 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 40041007396 HMMPfam hit to PF00004, AAA ATPase, core, score 2.5e-13 40041007397 PS00017 ATP/GTP-binding site motif A (P-loop). 40041007398 PS00870 Chaperonins clpA/B signature 1. 40041007399 HMMPfam hit to PF02151, UvrB/UvrC protein, score 0.00014 40041007400 HMMPfam hit to PF07724, ATPase AAA-2, score 2.6e-99 40041007401 PS00017 ATP/GTP-binding site motif A (P-loop). 40041007402 PS00871 Chaperonins clpA/B signature 2. 40041007403 Contains a crystal structure of the Nudix hydrolase from Enterococcus faecalis, which has an unknown function. In general, members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes...; Region: Nudix_Hydrolase_25; cd04684 40041007404 nudix motif; other site 40041007405 HMMPfam hit to PF00293, NUDIX hydrolase, core, score 1.9e-17 40041007406 PS00893 mutT domain signature. 40041007407 Domain of unknown function (DUF1827); Region: DUF1827; pfam08860 40041007408 HMMPfam hit to PF08860, Protein of unknown function DUF1827, score 5e-68 40041007409 isoleucyl-tRNA synthetase; Provisional; Region: ileS; PRK13804 40041007410 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 40041007411 active site 40041007412 HIGH motif; other site 40041007413 nucleotide binding site [chemical binding]; other site 40041007414 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 40041007415 active site 40041007416 KMSKS motif; other site 40041007417 Anticodon-binding domain of bacterial and eukaryotic mitochondrial isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_BEm; cd07960 40041007418 tRNA binding surface [nucleotide binding]; other site 40041007419 anticodon binding site; other site 40041007420 HMMPfam hit to PF06827, Formamidopyrimidine-DNA glycolase, C-terminal, score 5.6e-05 40041007421 HMMPfam hit to PF08264, Valyl/Leucyl/Isoleucyl-tRNA synthetase, class I, anticodon-binding, score 3.4e-54 40041007422 HMMPfam hit to PF00133, Aminoacyl-tRNA synthetase, class Ia, score 1.8e-275 40041007423 PS00178 Aminoacyl-transfer RNA synthetases class-I signature. 40041007424 DivIVA protein; Region: DivIVA; pfam05103 40041007425 DivIVA domain; Region: DivI1A_domain; TIGR03544 40041007426 HMMPfam hit to PF05103, DivIVA, score 1.4e-112 40041007427 Uncharacterized conserved protein, contains S4-like domain [Function unknown]; Region: COG2302 40041007428 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 40041007429 RNA binding surface [nucleotide binding]; other site 40041007430 HMMPfam hit to PF01479, RNA-binding S4, score 1.6e-10 40041007431 YGGT family; Region: YGGT; pfam02325 40041007432 HMMPfam hit to PF02325, Protein of unknown function YGGT, score 1.4e-26 40041007433 2 probable transmembrane helices predicted for SZO13930 by TMHMM2.0 at aa 7-29 and 59-81 40041007434 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1799 40041007435 HMMPfam hit to PF04472, Protein of unknown function DUF552, score 2.5e-45 40041007436 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, YBL036c-like proteins; Region: PLPDE_III_YBL036c_like; cd00635 40041007437 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 40041007438 catalytic residue [active] 40041007439 HMMPfam hit to PF01168, Alanine racemase, N-terminal, score 1.6e-07 40041007440 PS01211 Uncharacterized protein family UPF0001 signature. 40041007441 cell division protein FtsZ; Validated; Region: PRK09330 40041007442 FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes. FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201 40041007443 nucleotide binding site [chemical binding]; other site 40041007444 SulA interaction site; other site 40041007445 HMMPfam hit to PF03953, Tubulin/FtsZ, C-terminal, score 1.2e-24 40041007446 HMMPfam hit to PF00091, Tubulin/FtsZ, GTPase, score 7.4e-97 40041007447 PS01134 FtsZ protein signature 1. 40041007448 Cell division ATPase FtsA [Cell division and chromosome partitioning]; Region: ftsA; COG0849 40041007449 Cell division protein FtsA; Region: FtsA; smart00842 40041007450 Cell division protein FtsA; Region: FtsA; pfam14450 40041007451 Domain of unknown function (DUF3484); Region: DUF3484; pfam11983 40041007452 HMMPfam hit to PF02491, Cell division protein FtsA, score 4.8e-47 40041007453 HMMPfam hit to PF02491, Cell division protein FtsA, score 7.3e-70 40041007454 POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478 40041007455 Cell division protein FtsQ; Region: FtsQ; pfam03799 40041007456 HMMPfam hit to PF03799, Cell division protein FtsQ, score 2.7e-28 40041007457 HMMPfam hit to PF08478, Polypeptide-transport-associated, FtsQ-type, score 5.2e-16 40041007458 1 probable transmembrane helix predicted for SZO13980 by TMHMM2.0 at aa 116-138 40041007459 undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726 40041007460 MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785 40041007461 active site 40041007462 homodimer interface [polypeptide binding]; other site 40041007463 HMMPfam hit to PF04101, Glycosyltransferase 28, C-terminal, score 7.5e-26 40041007464 HMMPfam hit to PF03033, Glycosyl transferase, family 28, score 3.3e-38 40041007465 UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK02472 40041007466 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 40041007467 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 40041007468 HMMPfam hit to PF02875, Mur ligase, C-terminal, score 3e-17 40041007469 HMMPfam hit to PF08245, Mur ligase, central, score 1.3e-62 40041007470 Protein of unknown function (DUF3165); Region: DUF3165; pfam11364 40041007471 3 probable transmembrane helices predicted for SZO14010 by TMHMM2.0 at aa 2-21, 25-47 and 56-73 40041007472 Predicted membrane GTPase involved in stress response [Signal transduction mechanisms]; Region: TypA; COG1217 40041007473 Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891 40041007474 G1 box; other site 40041007475 putative GEF interaction site [polypeptide binding]; other site 40041007476 GTP/Mg2+ binding site [chemical binding]; other site 40041007477 Switch I region; other site 40041007478 G2 box; other site 40041007479 G3 box; other site 40041007480 Switch II region; other site 40041007481 G4 box; other site 40041007482 G5 box; other site 40041007483 BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu. BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691 40041007484 BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants. BipA is a highly...; Region: BipA_TypA_C; cd03710 40041007485 HMMPfam hit to PF00679, Translation elongation factor EFG/EF2, C-terminal, score 2.1e-27 40041007486 HMMPfam hit to PF03144, Translation elongation factor EFTu/EF1A, domain 2, score 3.1e-17 40041007487 HMMPfam hit to PF00009, Protein synthesis factor, GTP-binding, score 1.8e-68 40041007488 PS00301 GTP-binding elongation factors signature. 40041007489 PS00017 ATP/GTP-binding site motif A (P-loop). 40041007490 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 40041007491 active site residue [active] 40041007492 HMMPfam hit to PF00581, Rhodanese-like, score 1e-07 40041007493 1 probable transmembrane helix predicted for SZO14030 by TMHMM2.0 at aa 4-26 40041007494 ROK family protein (putative glucokinase); Region: ROK_glcA_fam; TIGR00744 40041007495 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 40041007496 nucleotide binding site [chemical binding]; other site 40041007497 HMMPfam hit to PF00480, ROK, score 3.9e-44 40041007498 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 40041007499 PS01125 ROK family signature. 40041007500 Bacterial protein of unknown function (DUF910); Region: DUF910; pfam06014 40041007501 HMMPfam hit to PF06014, Protein of unknown function DUF910, bacterial, score 1.6e-36 40041007502 DNA-binding ferritin-like protein (oxidative damage protectant) [Inorganic ion transport and metabolism]; Region: Dps; COG0783 40041007503 DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043 40041007504 dimerization interface [polypeptide binding]; other site 40041007505 DPS ferroxidase diiron center [ion binding]; other site 40041007506 ion pore; other site 40041007507 HMMPfam hit to PF00210, Ferritin and Dps, score 6.5e-33 40041007508 PS00818 Dps protein family signature 1. 40041007509 6 probable transmembrane helices predicted for SZO14070 by TMHMM2.0 at aa 4-21, 71-93, 108-130, 132-154, 169-186 and 193-212 40041007510 HMMPfam hit to PF01478, Peptidase A24A, prepilin type IV, score 4.9e-11 40041007511 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 40041007512 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 40041007513 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 40041007514 active site 40041007515 phosphorylation site [posttranslational modification] 40041007516 intermolecular recognition site; other site 40041007517 dimerization interface [polypeptide binding]; other site 40041007518 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 40041007519 DNA binding residues [nucleotide binding] 40041007520 dimerization interface [polypeptide binding]; other site 40041007521 HMMPfam hit to PF00196, Bacterial regulatory protein, LuxR, score 3.3e-23 40041007522 PS00622 Bacterial regulatory proteins, luxR family signature. 40041007523 Predicted helix-turn-helix motif with score 1453.000, SD 4.14 at aa 153-174, sequence KTSKEISQILFLSNGTIRNYIS 40041007524 HMMPfam hit to PF00072, Response regulator receiver, score 3.4e-32 40041007525 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 40041007526 Histidine kinase; Region: HisKA_3; pfam07730 40041007527 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 40041007528 ATP binding site [chemical binding]; other site 40041007529 Mg2+ binding site [ion binding]; other site 40041007530 G-X-G motif; other site 40041007531 HMMPfam hit to PF02518, ATP-binding region, ATPase-like, score 4.6e-10 40041007532 HMMPfam hit to PF07730, Histidine kinase, dimerisation and phosphoacceptor region, score 5.1e-18 40041007533 5 probable transmembrane helices predicted for SZO14090 by TMHMM2.0 at aa 12-31, 35-52, 65-87, 107-124 and 131-148 40041007534 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 40041007535 6 probable transmembrane helices predicted for SZO14100 by TMHMM2.0 at aa 13-35, 50-72, 93-115, 130-152, 159-181 and 211-233 40041007536 HMMPfam hit to PF01061, ABC-2 type transporter, score 1e-06 40041007537 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 40041007538 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 40041007539 Walker A/P-loop; other site 40041007540 ATP binding site [chemical binding]; other site 40041007541 Q-loop/lid; other site 40041007542 ABC transporter signature motif; other site 40041007543 Walker B; other site 40041007544 D-loop; other site 40041007545 H-loop/switch region; other site 40041007546 HMMPfam hit to PF00005, ABC transporter related, score 4.7e-43 40041007547 PS00211 ABC transporters family signature. 40041007548 PS00017 ATP/GTP-binding site motif A (P-loop). 40041007549 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 40041007550 PS00017 ATP/GTP-binding site motif A (P-loop). 40041007551 ribosomal RNA large subunit methyltransferase N; Provisional; Region: PRK14455 40041007552 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 40041007553 FeS/SAM binding site; other site 40041007554 HMMPfam hit to PF04055, Radical SAM, score 1.7e-13 40041007555 Protein of unknown function (DUF1027); Region: DUF1027; cl09961 40041007556 HMMPfam hit to PF06265, Protein of unknown function DUF1027, score 1e-56 40041007557 Predicted secreted protein containing a PDZ domain [Signal transduction mechanisms]; Region: SdrC; COG3480 40041007558 PDZ domain, also called DHR (Dlg homologous region) or GLGF (after a conserved sequence motif). Many PDZ domains bind C-terminal polypeptides, though binding to internal (non-C-terminal) polypeptides and even to lipids has been demonstrated; Region: PDZ; cl00117 40041007559 protein binding site [polypeptide binding]; other site 40041007560 1 probable transmembrane helix predicted for SZO14140 by TMHMM2.0 at aa 9-31 40041007561 phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168 40041007562 Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163 40041007563 active site 40041007564 (T/H)XGH motif; other site 40041007565 HMMPfam hit to PF01467, Cytidylyltransferase, score 7.7e-27 40041007566 Conserved hypothetical protein 95; Region: Cons_hypoth95; pfam03602 40041007567 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 40041007568 S-adenosylmethionine binding site [chemical binding]; other site 40041007569 HMMPfam hit to PF03602, Conserved hypothetical protein CHP00095, score 9.5e-92 40041007570 PS00092 N-6 Adenine-specific DNA methylases signature. 40041007571 Transposase [DNA replication, recombination, and repair]; Region: COG5421 40041007572 Transposase [DNA replication, recombination, and repair]; Region: COG5421 40041007573 Asparagine synthetase (aspartate-ammonia ligase) (AsnA) catalyses the conversion of L-aspartate to L-asparagine in the presence of ATP and ammonia. AsnA is a homodimeric enzyme which is structurally similiar to the catalytic core domain of class II...; Region: AsnA; cd00645 40041007574 dimer interface [polypeptide binding]; other site 40041007575 active site 40041007576 HMMPfam hit to PF03590, Aspartate--ammonia ligase, score 2.9e-180 40041007577 carbamate kinase; Reviewed; Region: PRK12686 40041007578 AAK_CK: Carbamate kinase (CK) catalyzes both the ATP-phosphorylation of carbamate and carbamoyl phosphate (CP) utilization with the production of ATP from ADP and CP. Both CK (this CD) and nonhomologous CP synthetase synthesize carbamoyl phosphate, an...; Region: AAK_CK; cd04235 40041007579 putative substrate binding site [chemical binding]; other site 40041007580 nucleotide binding site [chemical binding]; other site 40041007581 nucleotide binding site [chemical binding]; other site 40041007582 homodimer interface [polypeptide binding]; other site 40041007583 HMMPfam hit to PF00696, Aspartate/glutamate/uridylate kinase, score 1.5e-97 40041007584 hypothetical protein; Provisional; Region: PRK07205 40041007585 M20 Peptidase Xaa-His dipeptidase (PepV) degrades hydrophobic dipeptides; Region: M20_PepV; cd03888 40041007586 active site 40041007587 metal binding site [ion binding]; metal-binding site 40041007588 Predicted helix-turn-helix motif with score 1077.000, SD 2.86 at aa 422-443, sequence IVLADAYRAMDIYAEAIYRLTR 40041007589 HMMPfam hit to PF01546, Peptidase M20, score 9.1e-26 40041007590 Predicted membrane protein [Function unknown]; Region: COG1288 40041007591 C4-dicarboxylate anaerobic carrier; Region: DcuC; pfam03606 40041007592 HMMPfam hit to PF03606, C4-dicarboxylate anaerobic carrier, score 1.5e-244 40041007593 13 probable transmembrane helices predicted for SZO14210 by TMHMM2.0 at aa 13-35, 79-98, 119-138, 148-170, 175-197, 201-223, 261-279, 312-334, 341-363, 378-400, 407-429, 444-466 and 479-496 40041007594 ornithine carbamoyltransferase; Validated; Region: PRK02102 40041007595 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 40041007596 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 40041007597 HMMPfam hit to PF00185, Aspartate/ornithine carbamoyltransferase, Asp/Orn-binding region, score 1.1e-78 40041007598 HMMPfam hit to PF02729, Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding, score 7.8e-70 40041007599 PS00097 Aspartate and ornithine carbamoyltransferases signature. 40041007600 Autoinducer synthetase; Region: Autoind_synth; cl17404 40041007601 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 40041007602 Coenzyme A binding pocket [chemical binding]; other site 40041007603 HMMPfam hit to PF00583, GCN5-related N-acetyltransferase, score 2.4e-14 40041007604 arginine deiminase; Provisional; Region: PRK01388 40041007605 HMMPfam hit to PF02274, Amidinotransferase, score 2.1e-204 40041007606 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 40041007607 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 40041007608 ligand binding site [chemical binding]; other site 40041007609 flexible hinge region; other site 40041007610 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 40041007611 putative switch regulator; other site 40041007612 non-specific DNA interactions [nucleotide binding]; other site 40041007613 DNA binding site [nucleotide binding] 40041007614 sequence specific DNA binding site [nucleotide binding]; other site 40041007615 putative cAMP binding site [chemical binding]; other site 40041007616 HMMPfam hit to PF00325, Bacterial regulatory protein, Crp, score 2.4e-08 40041007617 Predicted helix-turn-helix motif with score 2209.000, SD 6.71 at aa 177-198, sequence LTTTDIAQMSGTTRETVSHVFR 40041007618 HMMPfam hit to PF00027, Cyclic nucleotide-binding, score 1.5e-18 40041007619 Ortholog of S. equi 4047 (FM204883) SEQ0595; CDS contains a frameshift after codon 2. Frameshift occurs at a polyA heptamer Similar to Streptococcus pyogenes serotype M1 ArgR1 arginine regulator UniProt:Q99YT5 (EMBL:AE004092) (157 aa) fasta scores: E()=9.7e-62, 93.5% id in 155 aa 40041007620 HMMPfam hit to PF01316, Arginine repressor, score 1.6e-23 40041007621 HMMPfam hit to PF02863, Arginine repressor, score 1.2e-25 40041007622 This CD includes bacterial (Agrobacterium tumefaciens and Caulobacter crescentus ProX, and Clostridium sticklandii PrdX) and eukaryotic (Plasmodium falciparum N-terminal ProRS editing domain) sequences. The C. sticklandii PrdX protein, a homolog of the...; Region: PrdX_deacylase; cd04335 40041007623 putative deacylase active site [active] 40041007624 HMMPfam hit to PF04073, YbaK/prolyl-tRNA synthetase associated region, score 5.9e-08 40041007625 Solo B3/4 domain (OB-fold DNA/RNA-binding) of Phe-aaRS-beta [General function prediction only]; Region: COG3382 40041007626 B3/4 domain; Region: B3_4; pfam03483 40041007627 HMMPfam hit to PF03483, B3/4, score 2.7e-27 40041007628 Uncharacterized protein conserved in bacteria [Function unknown]; Region: MmcQ; COG2315 40041007629 HMMPfam hit to PF04237, Protein of unknown function DUF419, score 1.5e-37 40041007630 PS00213 Lipocalin signature. 40041007631 Cache domain; Region: Cache_1; pfam02743 40041007632 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 40041007633 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 40041007634 dimerization interface [polypeptide binding]; other site 40041007635 Histidine kinase; Region: His_kinase; pfam06580 40041007636 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 40041007637 ATP binding site [chemical binding]; other site 40041007638 Mg2+ binding site [ion binding]; other site 40041007639 G-X-G motif; other site 40041007640 HMMPfam hit to PF02518, ATP-binding region, ATPase-like, score 7.4e-16 40041007641 HMMPfam hit to PF06580, Histidine kinase internal region, score 3.4e-43 40041007642 HMMPfam hit to PF00672, Histidine kinase, HAMP region, score 1.9e-13 40041007643 2 probable transmembrane helices predicted for SZO14300 by TMHMM2.0 at aa 10-29 and 281-303 40041007644 HMMPfam hit to PF02743, Cache, score 2.8e-18 40041007645 Response regulator receiver domain; Region: Response_reg; pfam00072 40041007646 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 40041007647 active site 40041007648 phosphorylation site [posttranslational modification] 40041007649 intermolecular recognition site; other site 40041007650 dimerization interface [polypeptide binding]; other site 40041007651 Helix-turn-helix domain; Region: HTH_18; pfam12833 40041007652 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 40041007653 HMMPfam hit to PF00165, Helix-turn-helix, AraC type, score 2.1e-12 40041007654 PS00041 Bacterial regulatory proteins, araC family signature. 40041007655 HMMPfam hit to PF00165, Helix-turn-helix, AraC type, score 8.8e-06 40041007656 Predicted helix-turn-helix motif with score 1473.000, SD 4.20 at aa 159-180, sequence LTLKSLSSQLGFSPNYLSVLIK 40041007657 HMMPfam hit to PF00072, Response regulator receiver, score 7.8e-39 40041007658 Peptide methionine sulfoxide reductase [Posttranslational modification, protein turnover, chaperones]; Region: MsrA; COG0225 40041007659 Conserved domain frequently associated with peptide methionine sulfoxide reductase [Posttranslational modification, protein turnover, chaperones]; Region: COG0229 40041007660 SelR domain; Region: SelR; pfam01641 40041007661 HMMPfam hit to PF01641, Methionine sulphoxide reductase B, score 2.8e-81 40041007662 HMMPfam hit to PF01625, Methionine sulphoxide reductase A, score 1.3e-82 40041007663 1 probable transmembrane helix predicted for SZO14320 by TMHMM2.0 at aa 7-29 40041007664 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 40041007665 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 40041007666 catalytic residues [active] 40041007667 HMMPfam hit to PF08534, Redoxin, score 1.6e-26 40041007668 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 40041007669 Cytochrome c biogenesis protein [Posttranslational modification, protein turnover, chaperones]; Region: CcdA; COG0785 40041007670 Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788 40041007671 6 probable transmembrane helices predicted for SZO14340 by TMHMM2.0 at aa 10-32, 51-73, 88-110, 130-152, 172-194 and 207-226 40041007672 HMMPfam hit to PF02683, Cytochrome c biogenesis protein, transmembrane region, score 1.8e-57 40041007673 PS00086 Cytochrome P450 cysteine heme-iron ligand signature. 40041007674 Helix-turn-helix domain of transposase family ISL3; Region: HTH_Tnp_ISL3; pfam13542 40041007675 Helix-turn-helix domain; Region: HTH_20; pfam12840 40041007676 putative DNA binding site [nucleotide binding]; other site 40041007677 Transposase; Region: DDE_Tnp_ISL3; pfam01610 40041007678 Predicted helix-turn-helix motif with score 1376.000, SD 3.87 at aa 130-151, sequence EAFTHIAAKLAISTSTVYHKLK 40041007679 HMMPfam hit to PF01610, Transposase, IS204/IS1001/IS1096/IS1165, score 1.3e-06 40041007680 Ortholog of S. equi 4047 (FM204883) SEQ0584 40041007681 CRISPR spacers 40041007682 CRISPR spacers 40041007683 CRISPR spacers 40041007684 CRISPR spacers 40041007685 CRISPR spacers 40041007686 CRISPR spacers 40041007687 CRISPR spacers 40041007688 CRISPR spacers 40041007689 CRISPR spacers 40041007690 CRISPR spacers 40041007691 CRISPR spacers 40041007692 CRISPR spacers 40041007693 CRISPR spacers 40041007694 CRISPR spacers 40041007695 CRISPR spacers 40041007696 CRISPR spacers 40041007697 CRISPR spacers 40041007698 CRISPR spacers 40041007699 CRISPR/Cas system-associated protein Cas2; Region: Cas2_I_II_III; cd09725 40041007700 HMMPfam hit to PF02647, Protein of unknown function DUF196, score 4.3e-08 40041007701 CRISPR/Cas system-associated protein Cas1; Region: Cas1_I-C; cd09721 40041007702 HMMPfam hit to PF01867, Protein of unknown function DUF48, score 2.5e-40 40041007703 CRISPR-associated protein Cas4 (RecB family exonuclease) [Defense mechanisms]; Region: COG1468 40041007704 CRISPR/Cas system-associated RAMP superfamily protein Cas7; Region: Cas7_I-C; cl01465 40041007705 HMMPfam hit to PF05107, CRISPR-associated protein TM1801, score 7.7e-158 40041007706 CRISPR/Cas system-associated protein Cas8c; Region: Cas8c_I-C; cl12004 40041007707 CRISPR-associated protein (Cas_Cas5); Region: Cas_Cas5d; pfam09704 40041007708 CRISPR/Cas system-associated RAMP superfamily protein Cas5; Region: Cas5_I; cl12040 40041007709 CRISPR/Cas system-associated protein Cas3'' Region: Cas3''_I; cd09641 40041007710 CRISPR-associated helicase Cas3 [Defense mechanisms]; Region: COG1203 40041007711 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 40041007712 HMMPfam hit to PF00271, DNA/RNA helicase, C-terminal, score 0.00089 40041007713 HMMPfam hit to PF01966, Metal-dependent phosphohydrolase, HD region, subdomain, score 2.8e-05 40041007714 Protein of unknown function (DUF4237); Region: DUF4237; pfam14021 40041007716 Protein of unknown function (DUF4225); Region: DUF4225; pfam13988 40041007717 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 40041007718 1 probable transmembrane helix predicted for SZO14510 by TMHMM2.0 at aa 39-61 40041007719 Domain of unknown function (DUF4299); Region: DUF4299; pfam14132 40041007720 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 40041007721 1 probable transmembrane helix predicted for SZO14560 by TMHMM2.0 at aa 39-61 40041007722 LXG domain of WXG superfamily; Region: LXG; pfam04740 40041007723 Protein of unknown function (DUF4225); Region: DUF4225; pfam13988 40041007724 1 probable transmembrane helix predicted for SZO14590 by TMHMM2.0 at aa 259-281 40041007725 Protein of unknown function (DUF3130; Region: DUF3130; cl12867 40041007726 Domain of unknown function (DUF4176); Region: DUF4176; pfam13780 40041007727 type VII secretion protein EssC, C-terminal domain; Region: T7_EssCb_Firm; TIGR03928 40041007728 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 40041007729 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 40041007730 HMMPfam hit to PF01580, Cell divisionFtsK/SpoIIIE, score 7e-24 40041007731 HMMPfam hit to PF01580, Cell divisionFtsK/SpoIIIE, score 3.4e-38 40041007732 PS00017 ATP/GTP-binding site motif A (P-loop). 40041007733 1 probable transmembrane helix predicted for SZO14630 by TMHMM2.0 at aa 213-235 40041007734 WXG100 protein secretion system (Wss), protein YukC; Region: YukC; cl01868 40041007735 type VII secretion protein EssB; Region: T7_EssB; TIGR03926 40041007736 1 probable transmembrane helix predicted for SZO14640 by TMHMM2.0 at aa 210-232 40041007737 WXG100 protein secretion system (Wss), protein YukD; Region: YukD; cl17489 40041007738 2 probable transmembrane helices predicted for SZO14660 by TMHMM2.0 at aa 7-24 and 123-145 40041007739 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061 40041007740 6 probable transmembrane helices predicted for SZO14670 by TMHMM2.0 at aa 7-26, 879-898, 919-941, 951-973, 980-1002 and 1034-1056 40041007741 PS00215 Mitochondrial energy transfer proteins signature. 40041007742 PS00017 ATP/GTP-binding site motif A (P-loop). 40041007743 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4842 40041007744 HMMPfam hit to PF06013, Protein of unknown function DUF909, score 3.2e-33 40041007745 Branched-chain amino acid transport protein; Region: Branch_AA_trans; cl00547 40041007746 HMMPfam hit to PF05525, Branched-chain amino acid transport system II carrier protein, score 2.8e-168 40041007747 12 probable transmembrane helices predicted for SZO14690 by TMHMM2.0 at aa 7-26, 41-63, 76-98, 113-135, 148-170, 185-207, 227-249, 285-307, 320-342, 346-365, 378-400 and 410-432 40041007748 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 40041007749 ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK07187 40041007750 Ribonucleotide reductase N-terminal; Region: RNR_N; pfam08343 40041007751 Class I ribonucleotide reductase; Region: RNR_I; cd01679 40041007752 active site 40041007753 dimer interface [polypeptide binding]; other site 40041007754 catalytic residues [active] 40041007755 effector binding site; other site 40041007756 Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939 40041007757 HMMPfam hit to PF02867, Ribonucleotide reductase large subunit, C-terminal, score 4.3e-164 40041007758 PS00089 Ribonucleotide reductase large subunit signature. 40041007759 HMMPfam hit to PF00317, Ribonucleotide reductase large subunit, N-terminal, score 6.6e-25 40041007760 HMMPfam hit to PF08343, Ribonucleotide reductase N-terminal, score 5.5e-35 40041007761 ribonucleotide reductase stimulatory protein; Reviewed; Region: nrdI; PRK03600 40041007762 HMMPfam hit to PF07972, Ribonucleotide reductase Class Ib, NrdI, score 2.1e-72 40041007763 ribonucleotide-diphosphate reductase subunit beta; Provisional; Region: nrdF2; PRK13966 40041007764 Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049 40041007765 dimer interface [polypeptide binding]; other site 40041007766 putative radical transfer pathway; other site 40041007767 diiron center [ion binding]; other site 40041007768 tyrosyl radical; other site 40041007769 HMMPfam hit to PF00268, Ribonucleotide reductase, score 5.3e-39 40041007770 1 probable transmembrane helix predicted for SZO14720 by TMHMM2.0 at aa 170-192 40041007771 Probable gene remnant. Similar to the N-terminal region of Streptococcus suis 89/1591 uncharacterized protein. UniProt:Q302J3 (EMBL:AAFA02000007) (119 aa) fasta scores: E()=0.0025, 30.667% id in 75 aa 40041007772 bacteriocin secretion accessory protein; Region: bacteriocin_acc; TIGR01000 40041007773 HlyD family secretion protein; Region: HlyD_3; pfam13437 40041007774 HMMPfam hit to PF00529, Secretion protein HlyD, score 3.8e-05 40041007775 1 probable transmembrane helix predicted for SZO14730 by TMHMM2.0 at aa 19-41 40041007776 A sub-family of peptidase family C39. Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various...; Region: Peptidase_C39B; cd02418 40041007777 ABC-type bacteriocin transporter; Region: bacteriocin_ABC; TIGR01193 40041007778 putative active site [active] 40041007779 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 40041007780 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 40041007781 Walker A/P-loop; other site 40041007782 ATP binding site [chemical binding]; other site 40041007783 Q-loop/lid; other site 40041007784 ABC transporter signature motif; other site 40041007785 Walker B; other site 40041007786 D-loop; other site 40041007787 H-loop/switch region; other site 40041007788 HMMPfam hit to PF00005, ABC transporter related, score 4.9e-55 40041007789 PS00211 ABC transporters family signature. 40041007790 PS00017 ATP/GTP-binding site motif A (P-loop). 40041007791 HMMPfam hit to PF00664, ABC transporter, transmembrane region, score 5.2e-66 40041007792 4 probable transmembrane helices predicted for SZO14740 by TMHMM2.0 at aa 167-189, 196-218, 278-300 and 307-326 40041007793 HMMPfam hit to PF03412, Peptidase C39, bacteriocin processing, score 7.3e-64 40041007794 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 40041007795 non-specific DNA binding site [nucleotide binding]; other site 40041007796 salt bridge; other site 40041007797 sequence-specific DNA binding site [nucleotide binding]; other site 40041007798 HMMPfam hit to PF01381, Helix-turn-helix type 3, score 6.7e-07 40041007799 methionyl-tRNA synthetase; Reviewed; Region: PRK12267 40041007800 catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814 40041007801 active site 40041007802 HIGH motif; other site 40041007803 KMSKS motif; other site 40041007804 Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957 40041007805 tRNA binding surface [nucleotide binding]; other site 40041007806 anticodon binding site; other site 40041007807 tRNA-binding-domain-containing Escherichia coli methionyl-tRNA synthetase (EcMetRS)-like proteins. This family includes EcMetRS and Aquifex aeolicus Trbp111 (AaTrbp111). This domain has general tRNA binding properties. MetRS aminoacylates methionine...; Region: tRNA_bind_EcMetRS_like; cd02800 40041007808 dimer interface [polypeptide binding]; other site 40041007809 putative tRNA-binding site [nucleotide binding]; other site 40041007810 HMMPfam hit to PF01588, tRNA-binding region, score 1.3e-30 40041007811 HMMPfam hit to PF09334, Aminoacyl-tRNA synthetase, class I (M), score 6.7e-203 40041007812 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 40041007813 Predicted membrane protein [Function unknown]; Region: COG3619 40041007814 HMMPfam hit to PF06912, Protein of unknown function DUF1275, score 1e-77 40041007815 4 probable transmembrane helices predicted for SZO14770 by TMHMM2.0 at aa 12-34, 63-82, 94-116 and 178-200 40041007816 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 40041007817 Transposase; Region: DDE_Tnp_ISL3; pfam01610 40041007818 Predicted helix-turn-helix motif with score 1838.000, SD 5.45 at aa 119-140, sequence VSMTAIADRLSISTSTVMRKLN 40041007819 HMMPfam hit to PF01610, Transposase, IS204/IS1001/IS1096/IS1165, score 1.4e-47 40041007820 Gram-positive signal peptide, YSIRK family; Region: YSIRK_signal; TIGR01168 40041007821 Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461 40041007822 HMMPfam hit to PF00746, Surface protein from Gram-positive cocci, anchor region, score 1.5e-11 40041007823 2 probable transmembrane helices predicted for SZO14790 by TMHMM2.0 at aa 13-35 and 411-433 40041007824 PS00343 Gram-positive cocci surface proteins 'anchoring' hexapeptide. 40041007825 3 probable transmembrane helices predicted for SZO14800 by TMHMM2.0 at aa 5-27, 37-59 and 87-109 40041007826 Gram-positive signal peptide, YSIRK family; Region: YSIRK_signal; TIGR01168 40041007827 Peptidase S8 family domain in Streptococcal C5a peptidases; Region: Peptidases_S8_C5a_Peptidase; cd07475 40041007828 putative active site [active] 40041007829 catalytic triad [active] 40041007830 PA_C5a_like: Protease-associated domain containing proteins like Streptococcus pyogenes C5a peptidase. This group contains various PA domain-containing proteins similar to S. pyogenes C5a, including, i) Vpr, a minor extracellular serine protease from...; Region: PA_C5a_like; cd02133 40041007831 putative integrin binding motif; other site 40041007832 PA/protease domain interface [polypeptide binding]; other site 40041007833 Peptidase S8 family domain in Streptococcal C5a peptidases; Region: Peptidases_S8_C5a_Peptidase; cd07475 40041007834 Fn3-like domain (DUF1034); Region: DUF1034; pfam06280 40041007835 HMMPfam hit to PF00746, Surface protein from Gram-positive cocci, anchor region, score 1.7e-05 40041007836 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 40041007837 PS00343 Gram-positive cocci surface proteins 'anchoring' hexapeptide. 40041007838 HMMPfam hit to PF06280, Peptidase S8A, DUF1034 C-terminal, score 6.7e-46 40041007839 HMMPfam hit to PF00082, Peptidase S8 and S53, subtilisin, kexin, sedolisin, score 5.9e-41 40041007840 PS00138 Serine proteases, subtilase family, serine active site. 40041007841 HMMPfam hit to PF02225, Protease-associated PA, score 1.9e-14 40041007842 PS00137 Serine proteases, subtilase family, histidine active site. 40041007843 PS00136 Serine proteases, subtilase family, aspartic acid active site. 40041007844 1 probable transmembrane helix predicted for SZO14810 by TMHMM2.0 at aa 12-34 40041007845 HMMPfam hit to PF04650, YSIRK Gram-positive signal peptide, score 5.6e-07 40041007846 Human Ape1-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: Ape1-like_AP-endo; cd09087 40041007847 active site 40041007848 putative catalytic site [active] 40041007849 DNA binding site [nucleotide binding] 40041007850 putative phosphate binding site [ion binding]; other site 40041007851 metal binding site A [ion binding]; metal-binding site 40041007852 AP binding site [nucleotide binding]; other site 40041007853 metal binding site B [ion binding]; metal-binding site 40041007854 HMMPfam hit to PF03372, Endonuclease/exonuclease/phosphatase, score 9.8e-42 40041007855 PS00726 AP endonucleases family 1 signature 1. 40041007856 PS00728 AP endonucleases family 1 signature 3. 40041007857 Arsenate Reductase (ArsC) family, unknown subfamily; uncharacterized proteins containing a CXXC motif with similarity to thioredoxin (TRX)-fold arsenic reductases, ArsC. Proteins containing a redox active CXXC motif like TRX and glutaredoxin (GRX)...; Region: ArsC_like; cd03036 40041007858 ArsC family; Region: ArsC; pfam03960 40041007859 putative ArsC-like catalytic residues; other site 40041007860 putative TRX-like catalytic residues [active] 40041007861 HMMPfam hit to PF03960, Arsenate reductase and related, score 1.4e-27 40041007862 Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350 40041007863 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 40041007864 DNA binding site [nucleotide binding] 40041007865 active site 40041007866 HMMPfam hit to PF01035, Methylated-DNA-[protein]-cysteine S-methyltransferase, DNA binding, score 2e-39 40041007867 PS00374 Methylated-DNA--protein-cysteine methyltransferase active site. 40041007868 Acetyltransferase (GNAT) domain; Region: Acetyltransf_8; pfam13523 40041007869 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 40041007870 Coenzyme A binding pocket [chemical binding]; other site 40041007871 HMMPfam hit to PF00583, GCN5-related N-acetyltransferase, score 1.4e-05 40041007872 CutC family; Region: CutC; pfam03932 40041007873 HMMPfam hit to PF03932, CutC, score 8.7e-115 40041007874 Uncharacterized distant relative of cell wall-associated hydrolases [Function unknown]; Region: COG3863 40041007875 1 probable transmembrane helix predicted for SZO14880 by TMHMM2.0 at aa 5-27 40041007876 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 40041007877 Fibronectin-binding protein signal sequence; Region: Fb_signal; pfam08341 40041007878 TQXA domain; Region: TQXA_dom; TIGR03934 40041007879 HMMPfam hit to PF08341, Fibronectin-binding, signal sequence, score 5.1e-09 40041007880 HMMPfam hit to PF01391, Collagen triple helix repeat, score 1.2e-12 40041007881 HMMPfam hit to PF01391, Collagen triple helix repeat, score 1.6e-13 40041007882 HMMPfam hit to PF01391, Collagen triple helix repeat, score 2e-14 40041007883 HMMPfam hit to PF01391, Collagen triple helix repeat, score 4.9e-15 40041007884 1 probable transmembrane helix predicted for SZO14890 by TMHMM2.0 at aa 705-724 40041007885 ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698 40041007886 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 40041007887 6 probable transmembrane helices predicted for SZO14900 by TMHMM2.0 at aa 20-42, 182-204, 225-247, 257-279, 292-314 and 345-367 40041007888 HMMPfam hit to PF01061, ABC-2 type transporter, score 1.2e-16 40041007889 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 40041007890 ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698 40041007891 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 40041007892 6 probable transmembrane helices predicted for SZO14910 by TMHMM2.0 at aa 20-39, 182-204, 225-247, 262-284, 289-311 and 345-367 40041007893 HMMPfam hit to PF01061, ABC-2 type transporter, score 4.2e-13 40041007894 HMMPfam hit to PF01061, ABC-2 type transporter, score 9.4e-06 40041007895 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 40041007896 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 40041007897 Walker A/P-loop; other site 40041007898 ATP binding site [chemical binding]; other site 40041007899 Q-loop/lid; other site 40041007900 ABC transporter signature motif; other site 40041007901 Walker B; other site 40041007902 D-loop; other site 40041007903 H-loop/switch region; other site 40041007904 HMMPfam hit to PF00005, ABC transporter related, score 3.9e-66 40041007905 PS00211 ABC transporters family signature. 40041007906 PS00017 ATP/GTP-binding site motif A (P-loop). 40041007907 6 probable transmembrane helices predicted for SZO14930 by TMHMM2.0 at aa 4-21, 42-64, 84-106, 134-156, 160-182 and 189-211 40041007908 CAAX protease self-immunity; Region: Abi; pfam02517 40041007909 HMMPfam hit to PF02517, Abortive infection protein, score 0.00014 40041007910 5 probable transmembrane helices predicted for SZO14940 by TMHMM2.0 at aa 7-29, 39-61, 74-96, 147-169 and 182-204 40041007911 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 40041007912 thiazole/oxazole-forming peptide maturase, SagD family component; Region: TOMM_cyclo_SagD; TIGR03604 40041007913 YcaO-like family; Region: YcaO; pfam02624 40041007914 HMMPfam hit to PF02624, YcaO-like, score 1.3e-07 40041007915 thiazole/oxazole-forming peptide maturase, SagC family component; Region: cyclo_dehy_ocin; TIGR03603 40041007916 This family is the oxydase domain of NRPS (non-ribosomal peptide synthetase) and other proteins that modify polypeptides by cyclizing a thioester to form a ring. These include epoB, part of the epothilone biosynthesis pathway; tubD, part of the tubulysin...; Region: mcbC-like_oxidoreductase; cd02142 40041007917 putative FMN binding site [chemical binding]; other site 40041007918 NADPH bind site [chemical binding]; other site 40041007919 hypothetical protein; Provisional; Region: PRK02539 40041007920 HMMPfam hit to PF05979, Protein of unknown function DUF896, bacterial, score 2.9e-42 40041007921 glycyl-tRNA synthetase subunit beta; Validated; Region: glyS; PRK01233 40041007922 DALR anticodon binding domain; Region: DALR_1; pfam05746 40041007923 HMMPfam hit to PF05746, DALR anticodon binding, score 0.00051 40041007924 HMMPfam hit to PF02092, Glycyl-tRNA synthetase, class IIc, beta subunit, N-terminal, score 4.8e-224 40041007925 Class II Glycyl-tRNA synthetase (GlyRS) alpha subunit core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes and in arabidopsis. It is responsible for the...; Region: GlyRS_alpha_core; cd00733 40041007926 dimer interface [polypeptide binding]; other site 40041007927 motif 1; other site 40041007928 active site 40041007929 motif 2; other site 40041007930 motif 3; other site 40041007931 HMMPfam hit to PF02091, Glycyl-tRNA synthetase, class IIc, alpha subunit, score 4.3e-220 40041007932 PS00339 Aminoacyl-transfer RNA synthetases class-II signature 2. 40041007933 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1755 40041007934 HMMPfam hit to PF04140, Isoprenylcysteine carboxyl methyltransferase, score 3.2e-47 40041007935 4 probable transmembrane helices predicted for SZO15020 by TMHMM2.0 at aa 2-18, 44-61, 68-90 and 131-153 40041007936 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 40041007937 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 40041007938 Walker A/P-loop; other site 40041007939 ATP binding site [chemical binding]; other site 40041007940 Q-loop/lid; other site 40041007941 ABC transporter signature motif; other site 40041007942 Walker B; other site 40041007943 D-loop; other site 40041007944 H-loop/switch region; other site 40041007945 HMMPfam hit to PF00005, ABC transporter related, score 6.6e-18 40041007946 PS00211 ABC transporters family signature. 40041007947 PS00017 ATP/GTP-binding site motif A (P-loop). 40041007948 4 probable transmembrane helices predicted for SZO15040 by TMHMM2.0 at aa 12-34, 306-328, 354-373 and 378-400 40041007949 4 probable transmembrane helices predicted for SZO15050 by TMHMM2.0 at aa 44-63, 238-260, 281-303 and 308-330 40041007950 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 40041007951 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 40041007952 active site 40041007953 catalytic tetrad [active] 40041007954 HMMPfam hit to PF00248, Aldo/keto reductase, score 3.2e-110 40041007955 PS00063 Aldo/keto reductase family active site signature. 40041007956 PS00062 Aldo/keto reductase family signature 2. 40041007957 PS00798 Aldo/keto reductase family signature 1. 40041007958 N-acetylglucosamine-6-phosphate deacetylase [Carbohydrate transport and metabolism]; Region: NagA; COG1820 40041007959 N-acetylglucosamine-6-phosphate deacetylase, NagA, catalyzes the hydrolysis of the N-acetyl group of N-acetyl-glucosamine-6-phosphate (GlcNAc-6-P) to glucosamine 6-phosphate and acetate. This is the first committed step in the biosynthetic pathway to...; Region: NagA; cd00854 40041007960 active site 40041007961 dimer interface [polypeptide binding]; other site 40041007962 HMMPfam hit to PF01979, Amidohydrolase 1, score 2.1e-06 40041007963 Na+/phosphate symporter [Inorganic ion transport and metabolism]; Region: NptA; COG1283 40041007964 Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690 40041007965 Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690 40041007966 PhoU domain; Region: PhoU; pfam01895 40041007967 PhoU domain; Region: PhoU; pfam01895 40041007968 HMMPfam hit to PF01895, PhoU, score 6.2e-05 40041007969 HMMPfam hit to PF01895, PhoU, score 0.00027 40041007970 8 probable transmembrane helices predicted for SZO15090 by TMHMM2.0 at aa 10-27, 47-64, 69-91, 103-125, 135-152, 177-199, 214-236 and 249-271 40041007971 HMMPfam hit to PF02690, Na+/Pi-cotransporter, score 8.9e-12 40041007972 HMMPfam hit to PF02690, Na+/Pi-cotransporter, score 3.4e-79 40041007973 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 40041007974 1 probable transmembrane helix predicted for SZO15100 by TMHMM2.0 at aa 9-31 40041007975 D-ribose transporter subunit RbsB; Provisional; Region: PRK10653 40041007976 Periplasmic sugar-binding domain of the thermophilic Thermoanaerobacter tengcongensis ribose binding protein (ttRBP) and its mesophilic homologs; Region: PBP1_ribose_binding; cd06323 40041007977 ligand binding site [chemical binding]; other site 40041007978 dimerization interface [polypeptide binding]; other site 40041007979 HMMPfam hit to PF00532, Periplasmic binding protein/LacI transcriptional regulator, score 2.3e-06 40041007980 1 probable transmembrane helix predicted for SZO15110 by TMHMM2.0 at aa 7-29 40041007981 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 40041007982 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 40041007983 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 40041007984 TM-ABC transporter signature motif; other site 40041007985 HMMPfam hit to PF02653, Bacterial inner-membrane translocator, score 1.5e-70 40041007986 7 probable transmembrane helices predicted for SZO15120 by TMHMM2.0 at aa 10-32, 39-61, 76-98, 105-127, 158-180, 211-233 and 265-287 40041007987 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 40041007988 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 40041007989 Walker A/P-loop; other site 40041007990 ATP binding site [chemical binding]; other site 40041007991 Q-loop/lid; other site 40041007992 ABC transporter signature motif; other site 40041007993 Walker B; other site 40041007994 D-loop; other site 40041007995 H-loop/switch region; other site 40041007996 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 40041007997 HMMPfam hit to PF00005, ABC transporter related, score 7.4e-28 40041007998 PS00211 ABC transporters family signature. 40041007999 HMMPfam hit to PF00005, ABC transporter related, score 2.6e-54 40041008000 PS00211 ABC transporters family signature. 40041008001 PS00017 ATP/GTP-binding site motif A (P-loop). 40041008002 D-ribose pyranase; Provisional; Region: PRK11797 40041008003 HMMPfam hit to PF05025, RbsD or FucU transport, score 4.8e-73 40041008004 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 40041008005 Ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This reaction is the first step in the ribose metabolism. It traps ribose within the cell after uptake and also prepares the sugar for use in the synthesis of nucleotides...; Region: ribokinase; cd01174 40041008006 substrate binding site [chemical binding]; other site 40041008007 dimer interface [polypeptide binding]; other site 40041008008 ATP binding site [chemical binding]; other site 40041008009 HMMPfam hit to PF00294, Carbohydrate/purine kinase, score 1.2e-64 40041008010 PS00583 pfkB family of carbohydrate kinases signature 1. 40041008011 Transcriptional regulators [Transcription]; Region: PurR; COG1609 40041008012 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 40041008013 DNA binding site [nucleotide binding] 40041008014 domain linker motif; other site 40041008015 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 40041008016 HMMPfam hit to PF00532, Periplasmic binding protein/LacI transcriptional regulator, score 1.6e-09 40041008017 HMMPfam hit to PF00356, Bacterial regulatory protein, LacI, score 8.8e-10 40041008018 Predicted helix-turn-helix motif with score 2499.000, SD 7.70 at aa 6-27, sequence VTIKQVAKEAGLSKSTVSRYIS 40041008019 Uncharacterized protein conserved in bacteria [Function unknown]; Region: DegV; COG1307 40041008020 Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645 40041008021 HMMPfam hit to PF02645, DegV, score 4e-67 40041008022 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 40041008023 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 40041008024 HMMPfam hit to PF00440, Transcriptional regulator, TetR-like, DNA-binding, bacterial/archaeal, score 1.1e-07 40041008025 Predicted helix-turn-helix motif with score 1203.000, SD 3.28 at aa 45-66, sequence ITISELVARAGVSRNAFYRNYS 40041008026 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 40041008027 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 40041008028 active site 40041008029 motif I; other site 40041008030 motif II; other site 40041008031 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 40041008032 HMMPfam hit to PF08282, HAD superfamily hydrolase-like, type 3, score 5.4e-82 40041008033 PS01229 Hypothetical cof family signature 2. 40041008034 Predicted membrane protein [Function unknown]; Region: COG2860 40041008035 UPF0126 domain; Region: UPF0126; pfam03458 40041008036 UPF0126 domain; Region: UPF0126; pfam03458 40041008037 6 probable transmembrane helices predicted for SZO15200 by TMHMM2.0 at aa 5-27, 32-54, 67-86, 90-112, 119-141 and 161-183 40041008038 HMMPfam hit to PF03458, Protein of unknown function UPF0126, score 2e-32 40041008039 HMMPfam hit to PF03458, Protein of unknown function UPF0126, score 2.2e-27 40041008040 Domain of unknown function (DUF4300); Region: DUF4300; pfam14133 40041008041 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 40041008042 6-phospho-beta-galactosidase; Provisional; Region: PRK13511 40041008043 beta-galactosidase; Region: BGL; TIGR03356 40041008044 HMMPfam hit to PF00232, Glycoside hydrolase, family 1, score 1.5e-243 40041008045 PS00572 Glycosyl hydrolases family 1 active site. 40041008046 PS00653 Glycosyl hydrolases family 1 N-terminal signature. 40041008047 phosphotransferase system, lactose specific, IIC component; Region: lac_pts_IIC; TIGR00394 40041008048 Phosphotransferase system, EIIC; Region: PTS_EIIC; pfam02378 40041008049 PTS_IIB: subunit IIB of enzyme II (EII) is the central energy-coupling domain of the phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In the multienzyme PTS complex, EII is a carbohydrate-specific permease consisting of two cytoplasmic...; Region: PTS_IIB; cl10014 40041008050 active site 40041008051 P-loop; other site 40041008052 phosphorylation site [posttranslational modification] 40041008053 HMMPfam hit to PF02302, Phosphotransferase system, lactose/cellobiose-specific IIB subunit, score 3.9e-29 40041008054 8 probable transmembrane helices predicted for SZO15230 by TMHMM2.0 at aa 30-49, 64-83, 104-121, 131-153, 222-241, 282-304, 333-355 and 388-410 40041008055 HMMPfam hit to PF02378, Phosphotransferase system, EIIC, score 2.4e-110 40041008056 PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_lac; cd00215 40041008057 methionine cluster; other site 40041008058 active site 40041008059 phosphorylation site [posttranslational modification] 40041008060 metal binding site [ion binding]; metal-binding site 40041008061 HMMPfam hit to PF02255, Phosphotransferase system, lactose/cellobiose-specific IIA subunit, score 4.9e-55 40041008062 CAT RNA binding domain; Region: CAT_RBD; smart01061 40041008063 transcriptional antiterminator BglG; Provisional; Region: PRK09772 40041008064 PRD domain; Region: PRD; pfam00874 40041008065 PRD domain; Region: PRD; pfam00874 40041008066 HMMPfam hit to PF00874, PRD, score 8.8e-10 40041008067 HMMPfam hit to PF00874, PRD, score 6.8e-06 40041008068 HMMPfam hit to PF03123, CAT RNA-binding region, score 2.3e-20 40041008069 tagatose 1,6-diphosphate aldolase; Reviewed; Region: PRK04161 40041008070 HMMPfam hit to PF01791, Deoxyribose-phosphate aldolase/phospho-2-dehydro-3-deoxyheptonate aldolase, score 1.8e-101 40041008071 1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164 40041008072 tagatose-6-phosphate kinase; Region: lacC; TIGR01231 40041008073 putative substrate binding site [chemical binding]; other site 40041008074 putative ATP binding site [chemical binding]; other site 40041008075 HMMPfam hit to PF00294, Carbohydrate/purine kinase, score 2.2e-57 40041008076 PS00584 pfkB family of carbohydrate kinases signature 2. 40041008077 PS00583 pfkB family of carbohydrate kinases signature 1. 40041008078 galactose-6-phosphate isomerase subunit LacB; Reviewed; Region: PRK08622 40041008079 HMMPfam hit to PF02502, Ribose/galactose isomerase, score 5.8e-60 40041008080 galactose-6-phosphate isomerase subunit LacA; Provisional; Region: PRK12613 40041008081 HMMPfam hit to PF02502, Ribose/galactose isomerase, score 2.4e-54 40041008082 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 40041008083 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 40041008084 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 40041008085 HMMPfam hit to PF08220, Bacterial regulatory protein, DeoR N-terminal, score 3.4e-20 40041008086 PS00894 Bacterial regulatory proteins, deoR family signature. 40041008087 HMMPfam hit to PF00455, Bacterial regulatory protein, DeoR, score 4e-69 40041008088 LemA family; Region: LemA; cl00742 40041008089 HMMPfam hit to PF04011, LemA, score 1.2e-08 40041008090 2 probable transmembrane helices predicted for SZO15310 by TMHMM2.0 at aa 5-20 and 136-158 40041008091 Protein of unknown function (DUF3137); Region: DUF3137; pfam11335 40041008092 1 probable transmembrane helix predicted for SZO15320 by TMHMM2.0 at aa 45-62 40041008093 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 40041008094 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 40041008095 metal-binding site [ion binding] 40041008096 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 40041008097 Soluble P-type ATPase [General function prediction only]; Region: COG4087 40041008098 8 probable transmembrane helices predicted for SZO15340 by TMHMM2.0 at aa 94-116, 126-143, 164-186, 191-213, 347-369, 384-406, 688-710 and 714-736 40041008099 HMMPfam hit to PF00702, Haloacid dehalogenase-like hydrolase, score 2.2e-33 40041008100 PS00154 E1-E2 ATPases phosphorylation site. 40041008101 HMMPfam hit to PF00122, E1-E2 ATPase-associated region, score 6.1e-94 40041008102 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 40041008103 HMMPfam hit to PF00403, Heavy metal transport/detoxification protein, score 4.2e-15 40041008104 PS01047 Heavy-metal-associated domain. 40041008105 copper transport repressor, CopY/TcrY family; Region: CopY_TcrY; TIGR02698 40041008106 Penicillinase repressor; Region: Pencillinase_R; pfam03965 40041008107 HMMPfam hit to PF03965, Penicillinase repressor, score 9.8e-43 40041008108 Protein of unknown function (DUF2424); Region: DUF2424; pfam10340 40041008109 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 40041008110 HMMPfam hit to PF07859, Alpha/beta hydrolase fold-3, score 2e-29 40041008111 ribosome-binding factor A; Validated; Region: rbfA; PRK00521 40041008112 HMMPfam hit to PF02033, Ribosome-binding factor A, score 1.7e-28 40041008113 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 40041008114 translation initiation factor IF-2; Region: IF-2; TIGR00487 40041008115 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 40041008116 Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887 40041008117 G1 box; other site 40041008118 putative GEF interaction site [polypeptide binding]; other site 40041008119 GTP/Mg2+ binding site [chemical binding]; other site 40041008120 Switch I region; other site 40041008121 G2 box; other site 40041008122 G3 box; other site 40041008123 Switch II region; other site 40041008124 G4 box; other site 40041008125 G5 box; other site 40041008126 This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702 40041008127 Translation-initiation factor 2; Region: IF-2; pfam11987 40041008128 mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692 40041008129 HMMPfam hit to PF03144, Translation elongation factor EFTu/EF1A, domain 2, score 1.3e-11 40041008130 HMMPfam hit to PF00009, Protein synthesis factor, GTP-binding, score 1.9e-53 40041008131 PS00017 ATP/GTP-binding site motif A (P-loop). 40041008132 HMMPfam hit to PF04760, Translation initiation factor IF-2, N-terminal, score 3.7e-22 40041008133 PS00215 Mitochondrial energy transfer proteins signature. 40041008134 HMMPfam hit to PF04760, Translation initiation factor IF-2, N-terminal, score 2.5e-13 40041008135 hypothetical protein; Provisional; Region: PRK07283 40041008136 HMMPfam hit to PF01248, Ribosomal protein L7Ae/L30e/S12e/Gadd45, score 8.1e-20 40041008137 Ylxr homologs; group of conserved hypothetical bacterial proteins of unknown function; structure revealed putative RNA binding cleft; proteins are encoded by an operon that includes other proteins involved in transcription and/or translation; Region: YlxR; cd00279 40041008138 putative RNA binding cleft [nucleotide binding]; other site 40041008139 HMMPfam hit to PF04296, Protein of unknown function DUF448, score 2.2e-35 40041008140 transcription elongation factor NusA; Provisional; Region: nusA; PRK12327 40041008141 NusA N-terminal domain; Region: NusA_N; pfam08529 40041008142 S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455 40041008143 RNA binding site [nucleotide binding]; other site 40041008144 homodimer interface [polypeptide binding]; other site 40041008145 NusA-like KH domain; Region: KH_5; pfam13184 40041008146 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 40041008147 G-X-X-G motif; other site 40041008148 HMMPfam hit to PF00013, K Homology, type 1, score 0.03 40041008149 HMMPfam hit to PF00575, S1, RNA binding, score 0.00011 40041008150 HMMPfam hit to PF08529, Transcription factor NusA, N-terminal, score 1.2e-56 40041008151 Ortholog of S. equi 4047 (FM204883) SEQ0514; Probable gene remnant. CDS lacks appropriate translational start site 40041008152 HMMPfam hit to PF02576, Protein of unknown function DUF150, score 1.5e-63 40041008153 Ortholog of S. equi 4047 (FM204883) SEQ0511 40041008154 1 probable transmembrane helix predicted for SZO15430 by TMHMM2.0 at aa 20-42 40041008156 1 probable transmembrane helix predicted for SZO15440 by TMHMM2.0 at aa 21-40 40041008157 Ortholog of S. equi 4047 (FM204883) SEQ0509a 40041008158 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 40041008159 S-adenosylmethionine binding site [chemical binding]; other site 40041008160 HMMPfam hit to PF02390, methyltransferase, score 1.9e-55 40041008161 Thiamine kinase and related kinases [Coenzyme transport and metabolism]; Region: ycfN; COG0510 40041008162 Phosphotransferase enzyme family; Region: APH; pfam01636 40041008163 substrate binding site [chemical binding]; other site 40041008164 HMMPfam hit to PF01636, Aminoglycoside phosphotransferase, score 4.8e-32 40041008165 Bacterial ABC transporter protein EcsB; Region: EcsB; cl11542 40041008166 HMMPfam hit to PF05975, Bacterial ABC transporter EcsB, score 2e-145 40041008167 8 probable transmembrane helices predicted for SZO15480 by TMHMM2.0 at aa 19-41, 56-78, 103-122, 126-148, 229-248, 253-275, 296-313 and 317-335 40041008168 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 40041008169 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 40041008170 Walker A/P-loop; other site 40041008171 ATP binding site [chemical binding]; other site 40041008172 Q-loop/lid; other site 40041008173 ABC transporter signature motif; other site 40041008174 Walker B; other site 40041008175 D-loop; other site 40041008176 H-loop/switch region; other site 40041008177 HMMPfam hit to PF00005, ABC transporter related, score 2e-44 40041008178 PS00211 ABC transporters family signature. 40041008179 PS00017 ATP/GTP-binding site motif A (P-loop). 40041008180 HINT (histidine triad nucleotide-binding protein) subgroup: Members of this CD belong to the superfamily of histidine triad hydrolases that act on alpha-phosphate of ribonucleotides. This subgroup includes members from all three forms of cellular life; Region: HINT_subgroup; cd01277 40041008181 HIT family signature motif; other site 40041008182 catalytic residue [active] 40041008183 HMMPfam hit to PF01230, Histidine triad (HIT) protein, score 7.1e-31 40041008184 Transcriptional regulator [Transcription]; Region: LytR; COG1316 40041008185 HMMPfam hit to PF03816, Cell envelope-related transcriptional attenuator, score 5.7e-79 40041008186 1 probable transmembrane helix predicted for SZO15530 by TMHMM2.0 at aa 7-29 40041008187 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 40041008188 Coenzyme A binding pocket [chemical binding]; other site 40041008189 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 40041008190 HMMPfam hit to PF00583, GCN5-related N-acetyltransferase, score 5.5e-13 40041008191 Predicted ATPase or kinase [General function prediction only]; Region: COG0802 40041008192 HMMPfam hit to PF02367, Protein of unknown function UPF0079, ATPase bacteria, score 1e-40 40041008193 PS00017 ATP/GTP-binding site motif A (P-loop). 40041008194 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 40041008195 Predicted transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: COG1548; cl00668 40041008196 10 probable transmembrane helices predicted for SZO15560 by TMHMM2.0 at aa 20-42, 49-71, 91-113, 125-147, 196-218, 225-247, 257-276, 379-413, 433-455 and 468-485 40041008197 HMMPfam hit to PF00860, Xanthine/uracil/vitamin C permease, score 1.9e-10 40041008198 Predicted hydrolases of the HAD superfamily [General function prediction only]; Region: Cof; COG0561 40041008199 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 40041008200 active site 40041008201 motif I; other site 40041008202 motif II; other site 40041008203 HMMPfam hit to PF08282, HAD superfamily hydrolase-like, type 3, score 5.6e-79 40041008204 PTS system mannose-specific transporter subunits IIAB; Provisional; Region: PRK15088 40041008205 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006 40041008206 active pocket/dimerization site; other site 40041008207 active site 40041008208 phosphorylation site [posttranslational modification] 40041008209 PTS_IIB, PTS system, Mannose/sorbose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_man; cd00001 40041008210 active site 40041008211 phosphorylation site [posttranslational modification] 40041008212 HMMPfam hit to PF03610, Phosphotransferase system, fructose subfamily IIA component, score 9.4e-55 40041008213 HMMPfam hit to PF03830, Phosphotransferase system, sorbose subfamily IIB component, score 4.2e-88 40041008214 PTS system mannose-specific transporter subunit IIC; Provisional; Region: PRK15065 40041008215 HMMPfam hit to PF03609, Phosphotransferase system, sorbose-specific IIC subunit, score 2.4e-135 40041008216 7 probable transmembrane helices predicted for SZO15590 by TMHMM2.0 at aa 7-25, 35-57, 64-86, 96-118, 144-166, 181-203 and 210-243 40041008217 Phosphotransferase system, mannose/fructose/N-acetylgalactosamine-specific component IID [Carbohydrate transport and metabolism]; Region: ManZ; COG3716 40041008218 HMMPfam hit to PF03613, Phosphotransferase system, mannose/fructose/sorbose family IID component, score 4e-204 40041008219 5 probable transmembrane helices predicted for SZO15600 by TMHMM2.0 at aa 96-118, 123-145, 181-203, 260-277 and 284-302 40041008220 Domain of unknown function (DUF956); Region: DUF956; cl01917 40041008221 HMMPfam hit to PF06115, Protein of unknown function DUF956, score 1.1e-75 40041008222 Predicted O-acyltransferase [General function prediction only]; Region: COG3274 40041008223 Acyltransferase family; Region: Acyl_transf_3; pfam01757 40041008224 9 probable transmembrane helices predicted for SZO15620 by TMHMM2.0 at aa 31-53, 65-87, 102-124, 131-150, 165-183, 190-209, 213-235, 242-262 and 282-304 40041008225 seryl-tRNA synthetase; Provisional; Region: PRK05431 40041008226 Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403 40041008227 Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770 40041008228 dimer interface [polypeptide binding]; other site 40041008229 active site 40041008230 motif 1; other site 40041008231 motif 2; other site 40041008232 motif 3; other site 40041008233 HMMPfam hit to PF02403, Seryl-tRNA synthetase, class IIa, N-terminal, score 3.7e-44 40041008234 HMMPfam hit to PF00587, Aminoacyl-tRNA synthetase, class II (G, H, P and S), score 5.3e-70 40041008235 PS00179 Aminoacyl-transfer RNA synthetases class-II signature 1. 40041008236 acetyl-CoA carboxylase subunit alpha; Provisional; Region: PRK12319 40041008237 HMMPfam hit to PF03255, Acetyl-CoA carboxylase, alpha subunit, score 7.4e-22 40041008238 acetyl-CoA carboxylase subunit beta; Validated; Region: PRK05654 40041008239 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 40041008240 HMMPfam hit to PF01039, Carboxyl transferase, score 5.1e-11 40041008241 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591 40041008242 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 40041008243 ATP-grasp domain; Region: ATP-grasp_4; cl17255 40041008244 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 40041008245 HMMPfam hit to PF02785, Biotin carboxylase, C-terminal, score 1.4e-53 40041008246 HMMPfam hit to PF02786, Carbamoyl-phosphate synthase L chain, ATP-binding, score 1.7e-96 40041008247 PS00867 Carbamoyl-phosphate synthase subdomain signature 2. 40041008248 PS00238 Visual pigments (opsins) retinal binding site. 40041008249 PS00866 Carbamoyl-phosphate synthase subdomain signature 1. 40041008250 HMMPfam hit to PF00289, Carbamoyl-phosphate synthetase large chain, N-terminal, score 1e-44 40041008251 FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288 40041008252 HMMPfam hit to PF07977, Beta-hydroxyacyl-(acyl-carrier-protein) dehydratase, FabA/FabZ, score 1.5e-68 40041008253 acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated; Region: PRK06302 40041008254 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 40041008255 carboxyltransferase (CT) interaction site; other site 40041008256 biotinylation site [posttranslational modification]; other site 40041008257 HMMPfam hit to PF00364, Biotin/lipoyl attachment, score 7.5e-25 40041008258 3-oxoacyl-(acyl carrier protein) synthase II; Reviewed; Region: PRK07314 40041008259 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 40041008260 dimer interface [polypeptide binding]; other site 40041008261 active site 40041008262 HMMPfam hit to PF02801, Beta-ketoacyl synthase, C-terminal, score 1e-45 40041008263 HMMPfam hit to PF00109, Beta-ketoacyl synthase, N-terminal, score 3.2e-64 40041008264 PS00098 Thiolases acyl-enzyme intermediate signature. 40041008265 PS00606 Beta-ketoacyl synthases active site. 40041008266 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 40041008267 beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333 40041008268 NAD(P) binding site [chemical binding]; other site 40041008269 homotetramer interface [polypeptide binding]; other site 40041008270 homodimer interface [polypeptide binding]; other site 40041008271 active site 40041008272 HMMPfam hit to PF00106, Short-chain dehydrogenase/reductase SDR, score 1.6e-47 40041008273 PS00038 Myc-type, 'helix-loop-helix' dimerization domain signature. 40041008274 PS00061 Short-chain dehydrogenases/reductases family signature. 40041008275 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 40041008276 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 40041008277 HMMPfam hit to PF00698, Acyl transferase, score 1e-23 40041008278 putative enoyl-[acyl-carrier-protein] reductase II; Region: enACPred_II; TIGR03151 40041008279 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 40041008280 FMN binding site [chemical binding]; other site 40041008281 substrate binding site [chemical binding]; other site 40041008282 putative catalytic residue [active] 40041008283 HMMPfam hit to PF03060, 2-nitropropane dioxygenase, NPD, score 6.6e-108 40041008284 PS00912 Dihydroorotate dehydrogenase signature 2. 40041008285 acyl carrier protein; Provisional; Region: acpP; PRK00982 40041008286 HMMPfam hit to PF00550, Phosphopantetheine-binding, score 4.7e-12 40041008287 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352 40041008288 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 40041008289 dimer interface [polypeptide binding]; other site 40041008290 active site 40041008291 CoA binding pocket [chemical binding]; other site 40041008292 HMMPfam hit to PF08541, 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III C-terminal, score 5.4e-45 40041008293 HMMPfam hit to PF08545, 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III, score 7.4e-47 40041008294 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 40041008295 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 40041008296 putative Zn2+ binding site [ion binding]; other site 40041008297 putative DNA binding site [nucleotide binding]; other site 40041008298 dimerization interface [polypeptide binding]; other site 40041008299 HMMPfam hit to PF01047, Bacterial regulatory protein, MarR, score 3.3e-20 40041008300 Predicted helix-turn-helix motif with score 1065.000, SD 2.81 at aa 50-71, sequence VTPSDIARELMVTLGTVTTSLN 40041008301 PS00215 Mitochondrial energy transfer proteins signature. 40041008302 enoyl-CoA hydratase; Provisional; Region: PRK07260 40041008303 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 40041008304 substrate binding site [chemical binding]; other site 40041008305 oxyanion hole (OAH) forming residues; other site 40041008306 trimer interface [polypeptide binding]; other site 40041008307 HMMPfam hit to PF00378, Crotonase, core, score 6.7e-25 40041008308 chaperone protein DnaJ; Provisional; Region: PRK14276 40041008309 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 40041008310 HSP70 interaction site [polypeptide binding]; other site 40041008311 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cl03262 40041008312 substrate binding site [polypeptide binding]; other site 40041008313 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 40041008314 Zn binding sites [ion binding]; other site 40041008315 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 40041008316 dimer interface [polypeptide binding]; other site 40041008317 HMMPfam hit to PF01556, Chaperone DnaJ, C-terminal, score 2.5e-66 40041008318 HMMPfam hit to PF00684, DnaJ central region, score 2.1e-34 40041008319 PS00190 Cytochrome c family heme-binding site signature. 40041008320 PS00637 CXXCXGXG dnaJ domain signature. 40041008321 PS00190 Cytochrome c family heme-binding site signature. 40041008322 PS00225 Crystallins beta and gamma 'Greek key' motif signature. 40041008323 HMMPfam hit to PF00226, Heat shock protein DnaJ, N-terminal, score 1.7e-35 40041008324 PS00636 Nt-dnaJ domain signature. 40041008325 molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290 40041008326 Nucleotide-binding domain of human HSPA9 and similar proteins; Region: HSPA9-Ssq1-like_NBD; cd10234 40041008327 nucleotide binding site [chemical binding]; other site 40041008328 NEF interaction site [polypeptide binding]; other site 40041008329 SBD interface [polypeptide binding]; other site 40041008330 HMMPfam hit to PF00012, Heat shock protein 70, score 0 40041008331 PS01036 Heat shock hsp70 proteins family signature 3. 40041008332 PS00329 Heat shock hsp70 proteins family signature 2. 40041008333 PS00297 Heat shock hsp70 proteins family signature 1. 40041008334 GrpE; Region: GrpE; pfam01025 40041008335 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446 40041008336 dimer interface [polypeptide binding]; other site 40041008337 hsp70 (ATPase domain) interactions [polypeptide binding]; other site 40041008338 HMMPfam hit to PF01025, GrpE nucleotide exchange factor, score 3.5e-59 40041008339 PS01071 grpE protein signature. 40041008340 heat-inducible transcription repressor; Provisional; Region: hrcA; PRK00082 40041008341 HMMPfam hit to PF01628, Negative regulator of class I heat shock protein, score 2.2e-53 40041008342 Mannosyl-glycoprotein endo-beta-N-acetylglucosaminidase; Region: Glucosaminidase; cl17361 40041008343 HMMPfam hit to PF01832, Mannosyl-glycoprotein endo-beta-N-acetylglucosamidase, score 0.0029 40041008344 1 probable transmembrane helix predicted for SZO15810 by TMHMM2.0 at aa 7-29 40041008345 D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: VanY; COG1876 40041008346 D-alanyl-D-alanine carboxypeptidase; Region: VanY; pfam02557 40041008347 HMMPfam hit to PF02557, Peptidase M15B and M15C, D,D-carboxypeptidase VanY/endolysins, score 4.5e-50 40041008348 1 probable transmembrane helix predicted for SZO15820 by TMHMM2.0 at aa 7-26 40041008349 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 40041008350 catalytic core [active] 40041008351 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 40041008352 HMMPfam hit to PF00300, Phosphoglycerate mutase, score 1.1e-36 40041008353 Uncharacterized proteins with similarity to Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL_like_DUF711; cd08025 40041008354 HMMPfam hit to PF05167, Protein of unknown function DUF711, score 4.3e-269 40041008355 ACT domain proteins similar to the yet uncharacterized Streptococcus pneumoniae ACT domain protein; Region: ACT_1ZPV; cd04872 40041008356 HMMPfam hit to PF01842, Amino acid-binding ACT, score 1.1e-05 40041008357 Predicted membrane protein [Function unknown]; Region: COG2261 40041008358 HMMPfam hit to PF04226, Transglycosylase-associated protein, score 1.8e-12 40041008359 2 probable transmembrane helices predicted for SZO15860 by TMHMM2.0 at aa 2-19 and 53-75 40041008360 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 40041008361 EamA-like transporter family; Region: EamA; pfam00892 40041008362 10 probable transmembrane helices predicted for SZO15870 by TMHMM2.0 at aa 7-29, 33-55, 75-94, 99-118, 125-147, 152-174, 183-205, 215-237, 250-267 and 277-296 40041008363 HMMPfam hit to PF00892, Protein of unknown function DUF6, transmembrane, score 2.6e-17 40041008364 HMMPfam hit to PF00892, Protein of unknown function DUF6, transmembrane, score 1.9e-10 40041008365 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 40041008366 aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477 40041008367 GatB/GatE catalytic domain; Region: GatB_N; pfam02934 40041008368 GatB domain; Region: GatB_Yqey; pfam02637 40041008369 HMMPfam hit to PF02637, GatB/Yqey, score 8.7e-59 40041008370 HMMPfam hit to PF01162, GatB, central region, score 9.6e-31 40041008371 HMMPfam hit to PF02934, GatB N-terminal region, score 1.5e-143 40041008372 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 40041008373 aspartyl/glutamyl-tRNA amidotransferase subunit A; Reviewed; Region: gatA; PRK00012 40041008374 HMMPfam hit to PF01425, Amidase signature enzyme, score 1e-186 40041008375 aspartyl/glutamyl-tRNA amidotransferase subunit C; Reviewed; Region: gatC; PRK00034 40041008376 HMMPfam hit to PF02686, Glu-tRNAGln amidotransferase, C subunit, score 5.2e-13 40041008377 Isochorismatase family; Region: Isochorismatase; pfam00857 40041008378 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 40041008379 catalytic triad [active] 40041008380 conserved cis-peptide bond; other site 40041008381 HMMPfam hit to PF00857, Isochorismatase hydrolase, score 4.1e-14 40041008382 Pleiotropic transcriptional repressor [Transcription]; Region: CodY; COG4465 40041008383 CodY GAF-like domain; Region: CodY; pfam06018 40041008384 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 40041008385 dimerization interface [polypeptide binding]; other site 40041008386 putative Zn2+ binding site [ion binding]; other site 40041008387 putative DNA binding site [nucleotide binding]; other site 40041008388 HMMPfam hit to PF08222, GTP-sensing helix-turn-helix, CodY, C-terminal, score 1.6e-39 40041008389 Predicted helix-turn-helix motif with score 1428.000, SD 4.05 at aa 205-226, sequence LTASVIADRIGITRSVIVNALR 40041008390 HMMPfam hit to PF06018, GTP-sensing transcriptional pleiotropic repressor CodY, N-terminal, score 1.1e-121 40041008391 aminotransferase AlaT; Validated; Region: PRK09265 40041008392 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 40041008393 pyridoxal 5'-phosphate binding site [chemical binding]; other site 40041008394 homodimer interface [polypeptide binding]; other site 40041008395 catalytic residue [active] 40041008396 HMMPfam hit to PF00155, Aminotransferase, class I and II, score 1.8e-45 40041008397 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 40041008398 Ligand Binding Site [chemical binding]; other site 40041008399 HMMPfam hit to PF00582, UspA, score 6e-21 40041008400 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 40041008401 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 40041008402 active site 40041008403 motif I; other site 40041008404 motif II; other site 40041008405 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cl17915 40041008406 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4696 40041008407 metal binding site [ion binding]; metal-binding site 40041008408 HMMPfam hit to PF08282, HAD superfamily hydrolase-like, type 3, score 1.6e-85 40041008409 PS01229 Hypothetical cof family signature 2. 40041008410 PS01228 Hypothetical cof family signature 1. 40041008411 Type II (periplasmic) bacterial L-asparaginase; Region: L-asparaginase_II; cd08964 40041008412 active site 40041008413 homotetramer interface [polypeptide binding]; other site 40041008414 homodimer interface [polypeptide binding]; other site 40041008415 HMMPfam hit to PF00710, Asparaginase/glutaminase, score 8e-143 40041008416 PS00144 Asparaginase / glutaminase active site signature 1. 40041008417 ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917 40041008418 RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488 40041008419 generic binding surface II; other site 40041008420 ssDNA binding site; other site 40041008421 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 40041008422 ATP binding site [chemical binding]; other site 40041008423 putative Mg++ binding site [ion binding]; other site 40041008424 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 40041008425 nucleotide binding region [chemical binding]; other site 40041008426 ATP-binding site [chemical binding]; other site 40041008427 HMMPfam hit to PF00271, DNA/RNA helicase, C-terminal, score 1.4e-22 40041008428 HMMPfam hit to PF00270, DNA/RNA helicase, DEAD/DEAH box type, N-terminal, score 1e-35 40041008429 PS00017 ATP/GTP-binding site motif A (P-loop). 40041008430 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 40041008431 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 40041008432 Walker A/P-loop; other site 40041008433 ATP binding site [chemical binding]; other site 40041008434 Q-loop/lid; other site 40041008435 ABC transporter signature motif; other site 40041008436 Walker B; other site 40041008437 D-loop; other site 40041008438 H-loop/switch region; other site 40041008439 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 40041008440 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 40041008441 Walker A/P-loop; other site 40041008442 ATP binding site [chemical binding]; other site 40041008443 Q-loop/lid; other site 40041008444 ABC transporter signature motif; other site 40041008445 Walker B; other site 40041008446 D-loop; other site 40041008447 H-loop/switch region; other site 40041008448 HMMPfam hit to PF00005, ABC transporter related, score 3.2e-29 40041008449 PS00211 ABC transporters family signature. 40041008450 PS00017 ATP/GTP-binding site motif A (P-loop). 40041008451 HMMPfam hit to PF00005, ABC transporter related, score 2.2e-42 40041008452 PS00211 ABC transporters family signature. 40041008453 PS00675 Sigma-54 interaction domain ATP-binding region A signature. 40041008454 PS00017 ATP/GTP-binding site motif A (P-loop). 40041008455 ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619 40041008456 HMMPfam hit to PF02361, Cobalt transport protein, score 2.5e-12 40041008457 4 probable transmembrane helices predicted for SZO15990 by TMHMM2.0 at aa 21-43, 48-70, 77-99 and 114-132 40041008458 Hypothetical bacterial integral membrane protein (Trep_Strep); Region: Trep_Strep; pfam09605 40041008459 5 probable transmembrane helices predicted for SZO16000 by TMHMM2.0 at aa 10-32, 39-61, 76-98, 111-133 and 164-186 40041008460 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 40041008461 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 40041008462 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 40041008463 ATP-binding cassette domain of multidrug resistance protein-like transporters; Region: ABCC_MRP_Like; cd03228 40041008464 Walker A/P-loop; other site 40041008465 ATP binding site [chemical binding]; other site 40041008466 Q-loop/lid; other site 40041008467 ABC transporter signature motif; other site 40041008468 Walker B; other site 40041008469 D-loop; other site 40041008470 H-loop/switch region; other site 40041008471 HMMPfam hit to PF00005, ABC transporter related, score 2.8e-39 40041008472 PS00017 ATP/GTP-binding site motif A (P-loop). 40041008473 7 probable transmembrane helices predicted for SZO16010 by TMHMM2.0 at aa 21-43, 56-78, 85-102, 135-157, 164-183, 248-270 and 277-299 40041008474 ABC-type transport system involved in cytochrome bd biosynthesis, ATPase and permease components [Energy production and conversion / Posttranslational modification, protein turnover, chaperones]; Region: CydD; COG4988 40041008475 ATP-binding cassette domain of multidrug resistance protein-like transporters; Region: ABCC_MRP_Like; cd03228 40041008476 Walker A/P-loop; other site 40041008477 ATP binding site [chemical binding]; other site 40041008478 Q-loop/lid; other site 40041008479 ABC transporter signature motif; other site 40041008480 Walker B; other site 40041008481 D-loop; other site 40041008482 H-loop/switch region; other site 40041008483 HMMPfam hit to PF00005, ABC transporter related, score 5.5e-40 40041008484 PS00017 ATP/GTP-binding site motif A (P-loop). 40041008485 5 probable transmembrane helices predicted for SZO16020 by TMHMM2.0 at aa 29-51, 66-88, 159-181, 250-272 and 279-301 40041008486 PS00041 Bacterial regulatory proteins, araC family signature. 40041008487 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 40041008488 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 40041008489 Walker A/P-loop; other site 40041008490 ATP binding site [chemical binding]; other site 40041008491 Q-loop/lid; other site 40041008492 ABC transporter signature motif; other site 40041008493 Walker B; other site 40041008494 D-loop; other site 40041008495 H-loop/switch region; other site 40041008496 HMMPfam hit to PF00005, ABC transporter related, score 1.3e-50 40041008497 PS00211 ABC transporters family signature. 40041008498 PS00017 ATP/GTP-binding site motif A (P-loop). 40041008499 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 40041008500 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 40041008501 ABC-ATPase subunit interface; other site 40041008502 dimer interface [polypeptide binding]; other site 40041008503 putative PBP binding regions; other site 40041008504 HMMPfam hit to PF01032, Bacterial transport system permease, score 4.8e-86 40041008505 9 probable transmembrane helices predicted for SZO16040 by TMHMM2.0 at aa 21-43, 69-91, 103-122, 126-148, 155-177, 199-221, 249-271, 286-303 and 310-332 40041008506 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 40041008507 heme ABC transporter, heme-binding protein isdE; Region: IsdE; TIGR03659 40041008508 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 40041008509 intersubunit interface [polypeptide binding]; other site 40041008510 HMMPfam hit to PF01497, Periplasmic binding protein, score 3.9e-29 40041008511 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 40041008512 Cell surface heme-binding protein Shp; Region: HemeBinding_Shp; pfam11545 40041008513 2 probable transmembrane helices predicted for SZO16060 by TMHMM2.0 at aa 13-32 and 271-290 40041008514 Protein of unknown function (DUF1533); Region: DUF1533; pfam07550 40041008515 NEAr Transport domain, a component of cell surface proteins; Region: NEAT; cd06920 40041008516 heme-binding site [chemical binding]; other site 40041008517 Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond...; Region: LRR_RI; cl15309 40041008518 Leucine rich repeat; Region: LRR_8; pfam13855 40041008519 Leucine rich repeat; Region: LRR_8; pfam13855 40041008520 Leucine rich repeat; Region: LRR_8; pfam13855 40041008521 NEAr Transport domain, a component of cell surface proteins; Region: NEAT; cd06920 40041008522 heme-binding site [chemical binding]; other site 40041008523 1 probable transmembrane helix predicted for SZO16070 by TMHMM2.0 at aa 1225-1244 40041008524 HMMPfam hit to PF05031, NEAr transporter, score 1.8e-18 40041008525 HMMPfam hit to PF00560, Leucine-rich repeat, score 4.3 40041008526 HMMPfam hit to PF00560, Leucine-rich repeat, score 1.5 40041008527 HMMPfam hit to PF00560, Leucine-rich repeat, score 0.059 40041008528 HMMPfam hit to PF00560, Leucine-rich repeat, score 0.051 40041008529 HMMPfam hit to PF00560, Leucine-rich repeat, score 1.3 40041008530 HMMPfam hit to PF00560, Leucine-rich repeat, score 0.024 40041008531 HMMPfam hit to PF00560, Leucine-rich repeat, score 0.016 40041008532 PS00018 EF-hand calcium-binding domain. 40041008533 HMMPfam hit to PF05031, NEAr transporter, score 2e-26 40041008534 HMMPfam hit to PF07550, Protein of unknown function DUF1533, score 9.6e-14 40041008535 HMMPfam hit to PF07550, Protein of unknown function DUF1533, score 2.3e-06 40041008536 Surface antigen [General function prediction only]; Region: COG3942 40041008537 CHAP domain; Region: CHAP; pfam05257 40041008538 HMMPfam hit to PF05257, Cysteine, histidine-dependent amidohydrolase/peptidase, score 1.2e-45 40041008539 alanine racemase; Reviewed; Region: alr; PRK00053 40041008540 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430 40041008541 active site 40041008542 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 40041008543 dimer interface [polypeptide binding]; other site 40041008544 substrate binding site [chemical binding]; other site 40041008545 catalytic residues [active] 40041008546 HMMPfam hit to PF00842, Alanine racemase, C-terminal, score 8.7e-67 40041008547 HMMPfam hit to PF01168, Alanine racemase, N-terminal, score 1.3e-93 40041008548 PS00395 Alanine racemase pyridoxal-phosphate attachment site. 40041008549 4'-phosphopantetheinyl transferase; Provisional; Region: acpS; PRK00070 40041008550 HMMPfam hit to PF01648, 4'-phosphopantetheinyl transferase, score 1.2e-14 40041008551 preprotein translocase subunit SecA; Reviewed; Region: PRK12904 40041008552 SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958 40041008553 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cl17351 40041008554 nucleotide binding region [chemical binding]; other site 40041008555 ATP-binding site [chemical binding]; other site 40041008556 SEC-C motif; Region: SEC-C; pfam02810 40041008557 HMMPfam hit to PF02810, SEC-C motif, score 1.9e-07 40041008558 PS00200 Rieske iron-sulfur protein signature 2. 40041008559 HMMPfam hit to PF07516, SecA Wing and Scaffold, score 8e-68 40041008560 HMMPfam hit to PF00271, DNA/RNA helicase, C-terminal, score 0.0029 40041008561 PS01312 Protein secA signatures. 40041008562 HMMPfam hit to PF07517, SecA DEAD-like, score 2.6e-200 40041008563 HMMPfam hit to PF01043, SecA preprotein cross-linking region, score 3.3e-61 40041008564 Phosphomannose isomerase [Carbohydrate transport and metabolism]; Region: ManA; COG1482 40041008565 mannose-6-phosphate isomerase, class I; Region: manA; TIGR00218 40041008566 HMMPfam hit to PF01238, Mannose-6-phosphate isomerase, type I, score 3e-96 40041008567 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 40041008568 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 40041008569 nucleotide binding site [chemical binding]; other site 40041008570 HMMPfam hit to PF00480, ROK, score 1.8e-70 40041008571 PS01125 ROK family signature. 40041008572 Endo-beta-N-acetylglucosaminidases are bacterial chitinases that hydrolyze the chitin core of various asparagine (N)-linked glycans and glycoproteins. The endo-beta-N-acetylglucosaminidases have a glycosyl hydrolase family 18 (GH18) catalytic domain; Region: GH18_EndoS-like; cd06542 40041008573 active site 40041008574 PS01095 Chitinases family 18 active site. 40041008575 PTS system, sucrose-specific IIBC component; Region: PTS-II-BC-sucr; TIGR01996 40041008576 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 40041008577 active site turn [active] 40041008578 phosphorylation site [posttranslational modification] 40041008579 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 40041008580 Phosphotransferase system IIA components [Carbohydrate transport and metabolism]; Region: NagE; COG2190 40041008581 HPr interaction site; other site 40041008582 glycerol kinase (GK) interaction site [polypeptide binding]; other site 40041008583 active site 40041008584 phosphorylation site [posttranslational modification] 40041008585 HMMPfam hit to PF00358, Phosphotransferase system, sugar-specific permease EIIA 1 domain, score 1.7e-64 40041008586 PS00371 PTS EIIA domains phosphorylation site signature 1. 40041008587 10 probable transmembrane helices predicted for SZO16150 by TMHMM2.0 at aa 111-132, 152-174, 181-203, 213-235, 254-276, 291-313, 334-354, 364-386, 391-413 and 433-455 40041008588 HMMPfam hit to PF02378, Phosphotransferase system, EIIC, score 1.5e-47 40041008589 PS00044 Bacterial regulatory proteins, lysR family signature. 40041008590 HMMPfam hit to PF00367, Phosphotransferase system, EIIB, score 9.2e-19 40041008591 PS01035 PTS EIIB domains cysteine phosphorylation site signature. 40041008592 sucrose-6-phosphate hydrolase; Region: scrB_fam; TIGR01322 40041008593 Glycosyl hydrolase family 32, beta-fructosidases; Region: GH32_B_Fructosidase; cd08996 40041008594 substrate binding [chemical binding]; other site 40041008595 active site 40041008596 Glycosyl hydrolases family 32 C terminal; Region: Glyco_hydro_32C; pfam08244 40041008597 HMMPfam hit to PF00251, Glycosyl hydrolases family 32, N-terminal, score 8.1e-129 40041008598 HMMPfam hit to PF08244, Glycosyl hydrolase family 32, C-terminal, score 8.9e-16 40041008599 Transcriptional regulators [Transcription]; Region: PurR; COG1609 40041008600 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 40041008601 DNA binding site [nucleotide binding] 40041008602 domain linker motif; other site 40041008603 Ligand binding domain of the lacI-like transcription regulator from a novel metal-reducing bacterium Alkaliphilus Metalliredigens (strain Qymf) and its close homologs; Region: PBP1_Qymf_like; cd06291 40041008604 dimerization interface [polypeptide binding]; other site 40041008605 ligand binding site [chemical binding]; other site 40041008606 sodium binding site [ion binding]; other site 40041008607 HMMPfam hit to PF00356, Bacterial regulatory protein, LacI, score 8.4e-12 40041008608 Predicted helix-turn-helix motif with score 1960.000, SD 5.86 at aa 3-24, sequence AKLTDVAALAGVSPTTVSRVIN 40041008609 PS00356 Bacterial regulatory proteins, lacI family signature. 40041008610 PS00017 ATP/GTP-binding site motif A (P-loop). 40041008611 HMMPfam hit to PF00532, Periplasmic binding protein/LacI transcriptional regulator, score 1.6e-05 40041008612 transcription antitermination protein NusB; Reviewed; Region: nusB; PRK00202 40041008613 putative RNA binding site [nucleotide binding]; other site 40041008614 HMMPfam hit to PF01029, NusB/RsmB/TIM44, score 2.4e-28 40041008615 PS00339 Aminoacyl-transfer RNA synthetases class-II signature 2. 40041008616 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1302 40041008617 HMMPfam hit to PF03780, Protein of unknown function DUF322, score 7.6e-41 40041008618 elongation factor P; Validated; Region: PRK00529 40041008619 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 40041008620 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 40041008621 RNA binding site [nucleotide binding]; other site 40041008622 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 40041008623 RNA binding site [nucleotide binding]; other site 40041008624 HMMPfam hit to PF09285, Elongation factor P, C-terminal, score 9.9e-32 40041008625 PS01275 Elongation factor P signature. 40041008626 HMMPfam hit to PF01132, Translation elongation factor P/YeiP, central, score 2.2e-12 40041008627 HMMPfam hit to PF08207, Translation elongation factor, KOW-like, score 1.6e-18 40041008628 Deoxycytidylate deaminase domain. Deoxycytidylate deaminase catalyzes the deamination of dCMP to dUMP, providing the nucleotide substrate for thymidylate synthase. The enzyme binds Zn++, which is required for catalytic activity. The activity of the...; Region: deoxycytidylate_deaminase; cd01286 40041008629 catalytic motif [active] 40041008630 Zn binding site [ion binding]; other site 40041008631 HMMPfam hit to PF00383, CMP/dCMP deaminase, zinc-binding, score 8.4e-32 40041008632 PS00903 Cytidine and deoxycytidylate deaminases zinc-binding region signature. 40041008633 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 40041008634 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 40041008635 Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092 40041008636 active site 40041008637 HMMPfam hit to PF00557, Peptidase M24, catalytic core, score 3.3e-62 40041008638 PS00491 Aminopeptidase P and proline dipeptidase signature. 40041008639 HMMPfam hit to PF01321, Creatinase, score 6.9e-31 40041008640 excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349 40041008641 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 40041008642 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 40041008643 ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271 40041008644 HMMPfam hit to PF00005, ABC transporter related, score 1.5e-35 40041008645 PS00211 ABC transporters family signature. 40041008646 PS00190 Cytochrome c family heme-binding site signature. 40041008647 PS00017 ATP/GTP-binding site motif A (P-loop). 40041008648 PS00211 ABC transporters family signature. 40041008649 PS00190 Cytochrome c family heme-binding site signature. 40041008650 PS00017 ATP/GTP-binding site motif A (P-loop). 40041008651 Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598 40041008652 uncharacterized bacterial subfamily of the Escherichia coli CorA-Salmonella typhimurium ZntB family; Region: EcCorA_ZntB-like_u2; cd12827 40041008653 Cl binding site [ion binding]; other site 40041008654 oligomer interface [polypeptide binding]; other site 40041008655 HMMPfam hit to PF01544, Mg2+ transporter protein, CorA-like, score 2.6e-07 40041008656 2 probable transmembrane helices predicted for SZO16280 by TMHMM2.0 at aa 255-277 and 287-309 40041008657 Protein of unknown function (DUF1129); Region: DUF1129; cl11555 40041008658 HMMPfam hit to PF06570, Uncharacterised conserved protein UCP033111, membrane associated, score 4.3e-135 40041008659 4 probable transmembrane helices predicted for SZO16290 by TMHMM2.0 at aa 84-106, 116-138, 151-173 and 183-202 40041008660 30S ribosomal protein S18; Reviewed; Region: rpsR; PRK00391 40041008661 HMMPfam hit to PF01084, Ribosomal protein S18, score 6.3e-34 40041008662 PS00057 Ribosomal protein S18 signature. 40041008663 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 40041008664 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 40041008665 dimer interface [polypeptide binding]; other site 40041008666 ssDNA binding site [nucleotide binding]; other site 40041008667 tetramer (dimer of dimers) interface [polypeptide binding]; other site 40041008668 PS00583 pfkB family of carbohydrate kinases signature 1. 40041008669 HMMPfam hit to PF00436, Primosome PriB/single-strand DNA-binding, score 1.3e-31 40041008670 30S ribosomal protein S6; Reviewed; Region: rpsF; PRK00453 40041008671 HMMPfam hit to PF01250, Ribosomal protein S6, score 2.7e-28 40041008672 Ortholog of S. equi 4047 (FM204883) SEQ0405 40041008673 A/G-specific DNA glycosylase [DNA replication, recombination, and repair]; Region: MutY; COG1194 40041008674 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 40041008675 minor groove reading motif; other site 40041008676 helix-hairpin-helix signature motif; other site 40041008677 substrate binding pocket [chemical binding]; other site 40041008678 active site 40041008679 DNA glycosylase (MutY in bacteria and hMYH in humans) is responsible for repairing misread A*oxoG residues to C*G by removing the inappropriately paired adenine base from the DNA backbone. It belongs to the Nudix hydrolase superfamily and is important...; Region: DNA_Glycosylase_C; cd03431 40041008680 DNA binding and oxoG recognition site [nucleotide binding] 40041008681 HMMPfam hit to PF00730, HhH-GPD, score 4.2e-17 40041008682 HMMPfam hit to PF00633, Helix-hairpin-helix motif, score 5.6e-08 40041008683 2 probable transmembrane helices predicted for SZO16360 by TMHMM2.0 at aa 7-26 and 68-87 40041008684 hypothetical protein; Validated; Region: PRK09039 40041008685 1 probable transmembrane helix predicted for SZO16370 by TMHMM2.0 at aa 13-35 40041008686 HMMPfam hit to PF00746, Surface protein from Gram-positive cocci, anchor region, score 0.00016 40041008687 PS00343 Gram-positive cocci surface proteins 'anchoring' hexapeptide. 40041008688 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 40041008689 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 40041008690 catalytic residues [active] 40041008691 HMMPfam hit to PF00085, Thioredoxin domain, score 4.4e-32 40041008692 PS00194 Thioredoxin family active site. 40041008693 pyridine nucleotide-disulfide oxidoreductase; Provisional; Region: PRK07251 40041008694 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 40041008695 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 40041008696 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 40041008697 HMMPfam hit to PF07992, FAD-dependent pyridine nucleotide-disulphide oxidoreductase, score 1.2e-51 40041008698 PS00017 ATP/GTP-binding site motif A (P-loop). 40041008699 PS00076 Pyridine nucleotide-disulphide oxidoreductases class-I active site. 40041008700 HMMPfam hit to PF00070, Pyridine nucleotide-disulphide oxidoreductase, NAD-binding region, score 8.4e-30 40041008701 HMMPfam hit to PF02852, Pyridine nucleotide-disulphide oxidoreductase dimerisation region, score 2.9e-27 40041008702 Mismatch repair ATPase (MutS family) [DNA replication, recombination, and repair]; Region: COG1193 40041008703 MutS domain III; Region: MutS_III; pfam05192 40041008704 ATP-binding cassette domain of MutS2; Region: ABC_MutS2; cd03280 40041008705 Walker A/P-loop; other site 40041008706 ATP binding site [chemical binding]; other site 40041008707 Q-loop/lid; other site 40041008708 ABC transporter signature motif; other site 40041008709 Walker B; other site 40041008710 D-loop; other site 40041008711 H-loop/switch region; other site 40041008712 Smr domain; Region: Smr; pfam01713 40041008713 HMMPfam hit to PF01713, Smr protein/MutS2 C-terminal, score 4.2e-35 40041008714 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 40041008715 HMMPfam hit to PF00488, DNA mismatch repair protein MutS, C-terminal, score 1.3e-16 40041008716 PS00017 ATP/GTP-binding site motif A (P-loop). 40041008717 Uncharacterized membrane protein, required for colicin V production [General function prediction only]; Region: CvpA; COG1286 40041008718 Colicin V production protein; Region: Colicin_V; pfam02674 40041008719 HMMPfam hit to PF02674, Colicin V production protein, score 3e-45 40041008720 4 probable transmembrane helices predicted for SZO16420 by TMHMM2.0 at aa 2-19, 23-40, 80-102 and 122-144 40041008721 ribonuclease HIII; Provisional; Region: PRK00996 40041008722 Domain of unknown function (DUF3378); Region: DUF3378; pfam11858 40041008723 bacterial Ribonuclease HIII-like; Region: RNase_HII_bacteria_HIII_like; cd06590 40041008724 RNA/DNA hybrid binding site [nucleotide binding]; other site 40041008725 active site 40041008726 HMMPfam hit to PF01351, Ribonuclease HII/HIII, score 8.1e-62 40041008727 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 40041008728 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 40041008729 Catalytic site [active] 40041008730 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 40041008731 1 probable transmembrane helix predicted for SZO16450 by TMHMM2.0 at aa 7-26 40041008732 HMMPfam hit to PF00717, Peptidase S24, S26A and S26B, C-terminal, score 1.3e-20 40041008733 PS00501 Signal peptidases I serine active site. 40041008734 PS00760 Signal peptidases I lysine active site. 40041008735 helicase, putative, RecD/TraA family; Region: recD_rel; TIGR01448 40041008736 TENA/THI-4/PQQC family; Region: TENA_THI-4; cl15243 40041008737 AAA domain; Region: AAA_30; pfam13604 40041008738 Family description; Region: UvrD_C_2; pfam13538 40041008739 PS00017 ATP/GTP-binding site motif A (P-loop). 40041008740 4 probable transmembrane helices predicted for SZO16470 by TMHMM2.0 at aa 16-38, 69-91, 98-120 and 125-143 40041008741 putative transposase OrfB; Reviewed; Region: PHA02517 40041008742 HTH-like domain; Region: HTH_21; pfam13276 40041008743 Integrase core domain; Region: rve; pfam00665 40041008744 Integrase core domain; Region: rve_2; pfam13333 40041008745 HMMPfam hit to PF00665, Integrase, catalytic core, score 1.6e-41 40041008746 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 40041008747 Helix-turn-helix domain; Region: HTH_28; pfam13518 40041008748 Helix-turn-helix domain; Region: HTH_28; pfam13518 40041008749 Winged helix-turn helix; Region: HTH_29; pfam13551 40041008750 HMMPfam hit to PF01527, Transposase IS3/IS911, score 6e-07 40041008751 Predicted helix-turn-helix motif with score 1421.000, SD 4.03 at aa 159-180, sequence KDYQAAIEKYGISYQQVYSWVR 40041008752 HMMPfam hit to PF01527, Transposase IS3/IS911, score 1.1e-06 40041008753 DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586 40041008754 active site 40041008755 DNA polymerase IV; Validated; Region: PRK02406 40041008756 DNA binding site [nucleotide binding] 40041008757 HMMPfam hit to PF00817, UMUC-like DNA-repair protein, score 1.3e-100 40041008758 formate acetyltransferase 1; Region: pyr_form_ly_1; TIGR01255 40041008759 Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939 40041008760 HMMPfam hit to PF02901, Pyruvate formate-lyase, PFL, score 0 40041008761 HMMPfam hit to PF01228, Formate C-acetyltransferase glycine radical, score 3.2e-41 40041008762 PS00850 Glycine radical signature. 40041008763 Beta-lactamase; Region: Beta-lactamase; pfam00144 40041008764 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 40041008765 HMMPfam hit to PF00144, Beta-lactamase, score 1.3e-49 40041008766 PS00146 Beta-lactamase class-A active site. 40041008767 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 40041008768 active site 40041008769 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 40041008770 active site 40041008771 Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cd00333 40041008772 amphipathic channel; other site 40041008773 Asn-Pro-Ala signature motifs; other site 40041008774 6 probable transmembrane helices predicted for SZO16540 by TMHMM2.0 at aa 5-27, 42-64, 71-93, 152-171, 192-214 and 259-281 40041008775 HMMPfam hit to PF00230, Major intrinsic protein, score 5.7e-14 40041008776 PS00221 MIP family signature. 40041008777 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 40041008778 Ligand Binding Site [chemical binding]; other site 40041008779 HMMPfam hit to PF00582, UspA, score 1.2e-21 40041008780 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 40041008781 Major Facilitator Superfamily; Region: MFS_1; pfam07690 40041008782 putative substrate translocation pore; other site 40041008783 12 probable transmembrane helices predicted for SZO16560 by TMHMM2.0 at aa 13-35, 45-64, 76-98, 108-127, 134-156, 166-188, 209-231, 241-263, 276-295, 300-322, 335-357 and 372-389 40041008784 HMMPfam hit to PF07690, Major facilitator superfamily MFS-1, score 3.3e-50 40041008785 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 40041008786 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 40041008787 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cl17320 40041008788 non-specific DNA interactions [nucleotide binding]; other site 40041008789 DNA binding site [nucleotide binding] 40041008790 sequence specific DNA binding site [nucleotide binding]; other site 40041008791 putative cAMP binding site [chemical binding]; other site 40041008792 HMMPfam hit to PF00325, Bacterial regulatory protein, Crp, score 4.6e-06 40041008793 x-prolyl-dipeptidyl aminopeptidase; Provisional; Region: PRK05371 40041008794 X-Prolyl dipeptidyl aminopeptidase PepX, N-terminal; Region: PepX_N; pfam09168 40041008795 X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain; Region: PepX_C; pfam08530 40041008796 HMMPfam hit to PF09168, X-Prolyl dipeptidyl aminopeptidase PepX, N-terminal, score 7.1e-75 40041008797 HMMPfam hit to PF02129, Peptidase S15, score 1.3e-151 40041008798 HMMPfam hit to PF08530, Peptidase S15/CocE/NonD, C-terminal, score 3.8e-75 40041008799 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381 40041008800 HMMPfam hit to PF01243, Pyridoxamine 5'-phosphate oxidase-related, FMN-binding core, score 1.7e-20 40041008801 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 40041008802 non-specific DNA binding site [nucleotide binding]; other site 40041008803 salt bridge; other site 40041008804 sequence-specific DNA binding site [nucleotide binding]; other site 40041008805 HMMPfam hit to PF01381, Helix-turn-helix type 3, score 1.7e-11 40041008806 Predicted helix-turn-helix motif with score 1876.000, SD 5.58 at aa 22-43, sequence KTQKELSALTGISVRTLARYEK 40041008807 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 40041008808 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 40041008809 non-specific DNA binding site [nucleotide binding]; other site 40041008810 salt bridge; other site 40041008811 sequence-specific DNA binding site [nucleotide binding]; other site 40041008812 7 probable transmembrane helices predicted for SZO16610 by TMHMM2.0 at aa 7-24, 34-56, 76-98, 113-132, 153-172, 177-194 and 201-223 40041008813 HMMPfam hit to PF02517, Abortive infection protein, score 7.4e-19 40041008814 M protein trans-acting positive regulator (MGA) HTH domain; Region: HTH_Mga; pfam08280 40041008815 Mga helix-turn-helix domain; Region: Mga; pfam05043 40041008816 M protein trans-acting positive regulator (MGA) PRD domain; Region: PRD_Mga; pfam08270 40041008817 HMMPfam hit to PF08270, Mga DNA-binding trans-acting positive regulator, PRD region, score 1.6e-35 40041008818 HMMPfam hit to PF05043, M trans-acting positive regulator, score 7.3e-19 40041008819 HMMPfam hit to PF08280, Helix-turn-helix Mga, DNA-binding trans-acting positive regulator, score 3.3e-07 40041008820 Fibronectin-binding protein signal sequence; Region: Fb_signal; pfam08341 40041008821 TQXA domain; Region: TQXA_dom; TIGR03934 40041008822 Fibronectin binding repeat; Region: Fn_bind; pfam02986 40041008823 Fibronectin binding repeat; Region: Fn_bind; pfam02986 40041008824 Fibronectin binding repeat; Region: Fn_bind; pfam02986 40041008825 Fibronectin binding repeat; Region: Fn_bind; pfam02986 40041008826 HMMPfam hit to PF08341, Fibronectin-binding, signal sequence, score 1.4e-12 40041008827 HMMPfam hit to PF02986, Fibronectin binding repeat, score 0.12 40041008828 HMMPfam hit to PF02986, Fibronectin binding repeat, score 6.8e-18 40041008829 HMMPfam hit to PF02986, Fibronectin binding repeat, score 8.9e-18 40041008830 HMMPfam hit to PF02986, Fibronectin binding repeat, score 1.5e-19 40041008831 HMMPfam hit to PF02986, Fibronectin binding repeat, score 1.9e-19 40041008832 1 probable transmembrane helix predicted for SZO16630 by TMHMM2.0 at aa 543-562 40041008833 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 40041008834 HAMP domain; Region: HAMP; pfam00672 40041008835 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 40041008836 dimer interface [polypeptide binding]; other site 40041008837 phosphorylation site [posttranslational modification] 40041008838 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 40041008839 ATP binding site [chemical binding]; other site 40041008840 Mg2+ binding site [ion binding]; other site 40041008841 G-X-G motif; other site 40041008842 HMMPfam hit to PF02518, ATP-binding region, ATPase-like, score 1.2e-37 40041008843 HMMPfam hit to PF00512, Histidine kinase A, N-terminal, score 1.4e-15 40041008844 HMMPfam hit to PF00672, Histidine kinase, HAMP region, score 8.5e-08 40041008845 2 probable transmembrane helices predicted for SZO16640 by TMHMM2.0 at aa 7-29 and 39-61 40041008846 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 40041008847 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 40041008848 active site 40041008849 phosphorylation site [posttranslational modification] 40041008850 intermolecular recognition site; other site 40041008851 dimerization interface [polypeptide binding]; other site 40041008852 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 40041008853 DNA binding site [nucleotide binding] 40041008854 HMMPfam hit to PF00486, Transcriptional regulatory protein, C-terminal, score 6.6e-21 40041008855 HMMPfam hit to PF00072, Response regulator receiver, score 1.2e-42 40041008856 1 probable transmembrane helix predicted for SZO16660 by TMHMM2.0 at aa 13-35 40041008857 hypothetical protein; Validated; Region: PRK00153 40041008858 PS00017 ATP/GTP-binding site motif A (P-loop). 40041008859 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 40041008860 Helix-Turn-Helix DNA binding domain of the transcription regulators TipAL, Mta, and SkgA; Region: HTH_TipAL-Mta; cd01106 40041008861 DNA binding residues [nucleotide binding] 40041008862 dimer interface [polypeptide binding]; other site 40041008863 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 40041008864 zinc-ribbon domain; Region: zinc_ribbon_5; cl11777 40041008865 2 probable transmembrane helices predicted for SZO16670 by TMHMM2.0 at aa 147-166 and 170-189 40041008866 HMMPfam hit to PF00376, Bacterial regulatory protein, MerR, score 2.7e-12 40041008867 Predicted helix-turn-helix motif with score 1627.000, SD 4.73 at aa 8-29, sequence YSTGELAKAAGVTVRTVQYYDN 40041008868 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 40041008869 active site 40041008870 catalytic site [active] 40041008871 substrate binding site [chemical binding]; other site 40041008872 HMMPfam hit to PF00929, Exonuclease, RNase T and DNA polymerase III, score 2.8e-15 40041008873 HTH domain; Region: HTH_11; cl17392 40041008874 HMMPfam hit to PF04394, Protein of unknown function DUF536, score 5e-14 40041008875 Predicted helix-turn-helix motif with score 1868.000, SD 5.55 at aa 22-43, sequence KTVSELADILGVSRQAVNNRVK 40041008876 HI0933-like protein; Region: HI0933_like; pfam03486 40041008877 Chromate resistance exported protein; Region: Chrome_Resist; cl01744 40041008878 HMMPfam hit to PF03486, HI0933-like protein, score 2.6e-209 40041008879 30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08881 40041008880 HMMPfam hit to PF00253, Ribosomal protein S14, score 2.1e-17 40041008881 Uncharacterized conserved protein [Function unknown]; Region: COG1434 40041008882 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 40041008883 putative active site [active] 40041008884 5 probable transmembrane helices predicted for SZO16720 by TMHMM2.0 at aa 12-34, 49-71, 84-106, 126-148 and 304-326 40041008885 HMMPfam hit to PF02698, Protein of unknown function DUF218, score 8.4e-48 40041008886 UGMP family protein; Validated; Region: PRK09604 40041008887 Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214; cl17884 40041008888 Carbamoyltransferase; Region: CmcH_NodU; pfam02543 40041008889 HMMPfam hit to PF00814, Peptidase M22, glycoprotease, score 2.5e-76 40041008890 ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575 40041008891 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 40041008892 Coenzyme A binding pocket [chemical binding]; other site 40041008893 HMMPfam hit to PF00583, GCN5-related N-acetyltransferase, score 9.4e-16 40041008894 tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725 40041008895 Glycoprotease family; Region: Peptidase_M22; pfam00814 40041008896 HMMPfam hit to PF00814, Peptidase M22, glycoprotease, score 1.1e-54 40041008897 hypothetical protein; Provisional; Region: PRK13667 40041008898 HMMPfam hit to PF07288, Protein of unknown function DUF1447, score 4.8e-50 40041008899 mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595 40041008900 Metallo-beta-lactamase superfamily; Region: Lactamase_B; pfam00753 40041008901 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 40041008902 HMMPfam hit to PF00753, Beta-lactamase-like, score 1.5e-30 40041008903 HMMPfam hit to PF07521, RNA-metabolising metallo-beta-lactamase, score 1.4e-14 40041008904 PS01292 Uncharacterized protein family UPF0036 signature. 40041008905 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 40041008906 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 40041008907 Walker A/P-loop; other site 40041008908 ATP binding site [chemical binding]; other site 40041008909 Q-loop/lid; other site 40041008910 ABC transporter signature motif; other site 40041008911 Walker B; other site 40041008912 D-loop; other site 40041008913 H-loop/switch region; other site 40041008914 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352 40041008915 HMMPfam hit to PF08352, Oligopeptide/dipeptide ABC transporter, C-terminal, score 2.4e-08 40041008916 HMMPfam hit to PF00005, ABC transporter related, score 2e-61 40041008917 PS00211 ABC transporters family signature. 40041008918 PS00017 ATP/GTP-binding site motif A (P-loop). 40041008919 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 40041008920 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 40041008921 Walker A/P-loop; other site 40041008922 ATP binding site [chemical binding]; other site 40041008923 Q-loop/lid; other site 40041008924 ABC transporter signature motif; other site 40041008925 Walker B; other site 40041008926 D-loop; other site 40041008927 H-loop/switch region; other site 40041008928 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 40041008929 HMMPfam hit to PF08352, Oligopeptide/dipeptide ABC transporter, C-terminal, score 2.2e-27 40041008930 HMMPfam hit to PF00005, ABC transporter related, score 1.3e-56 40041008931 PS00017 ATP/GTP-binding site motif A (P-loop). 40041008932 oligopeptide ABC transporter permease OppC; Provisional; Region: PRK15406 40041008933 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 40041008934 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 40041008935 dimer interface [polypeptide binding]; other site 40041008936 conserved gate region; other site 40041008937 putative PBP binding loops; other site 40041008938 ABC-ATPase subunit interface; other site 40041008939 HMMPfam hit to PF00528, Binding-protein-dependent transport systems inner membrane component, score 7.1e-45 40041008940 5 probable transmembrane helices predicted for SZO16800 by TMHMM2.0 at aa 42-64, 142-164, 191-213, 253-275 and 307-329 40041008941 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 40041008942 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 40041008943 dimer interface [polypeptide binding]; other site 40041008944 conserved gate region; other site 40041008945 putative PBP binding loops; other site 40041008946 ABC-ATPase subunit interface; other site 40041008947 HMMPfam hit to PF00528, Binding-protein-dependent transport systems inner membrane component, score 3.3e-50 40041008948 6 probable transmembrane helices predicted for SZO16810 by TMHMM2.0 at aa 9-31, 94-116, 128-150, 165-184, 225-247 and 275-297 40041008949 Predicted helix-turn-helix motif with score 1106.000, SD 2.95 at aa 200-221, sequence TDYIQLARAKGLTKRQVTRRHA 40041008950 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 40041008951 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 40041008952 peptide binding site [polypeptide binding]; other site 40041008953 HMMPfam hit to PF00496, Bacterial extracellular solute-binding protein, family 5, score 2.7e-76 40041008954 1 probable transmembrane helix predicted for SZO16820 by TMHMM2.0 at aa 12-29 40041008955 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 40041008956 Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174 40041008957 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 40041008958 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 40041008959 HMMPfam hit to PF00120, Glutamine synthetase, catalytic region, score 2.2e-152 40041008960 HMMPfam hit to PF03951, Glutamine synthetase, beta-Grasp, score 6.5e-15 40041008961 PS00180 Glutamine synthetase signature 1. 40041008962 Helix-Turn-Helix DNA binding domain of GlnR-like transcription regulators; Region: HTH_GlnR-like; cd01105 40041008963 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 40041008964 DNA binding residues [nucleotide binding] 40041008965 putative dimer interface [polypeptide binding]; other site 40041008966 HMMPfam hit to PF00376, Bacterial regulatory protein, MerR, score 7.7e-11 40041008967 Predicted membrane protein [Function unknown]; Region: COG4129 40041008968 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 40041008969 4 probable transmembrane helices predicted for SZO16850 by TMHMM2.0 at aa 21-43, 58-80, 87-109 and 113-135 40041008970 phosphoglycerate kinase; Provisional; Region: pgk; PRK00073 40041008971 Phosphoglycerate kinase; Region: PGK; pfam00162 40041008972 substrate binding site [chemical binding]; other site 40041008973 hinge regions; other site 40041008974 ADP binding site [chemical binding]; other site 40041008975 catalytic site [active] 40041008976 HMMPfam hit to PF00162, Phosphoglycerate kinase, score 1.4e-179 40041008977 PS00111 Phosphoglycerate kinase signature. 40041008978 Ortholog of S. equi 4047 (FM204883) SEQ0346; CDS contains a nonsense mutation (ochre) after codon 11. Similar to Streptococcus equisimilis lppc acid phosphatase precursor. UniProt:O05471 (EMBL:Y12602) (285 aa) fasta scores: E()=4.1e-74, 67.9% id in 280 aa 40041008979 HMMPfam hit to PF03767, Acid phosphatase (Class B), score 2.3e-78 40041008980 Glyceraldehyde-3-phosphate dehydrogenase/erythrose-4-phosphate dehydrogenase [Carbohydrate transport and metabolism]; Region: GapA; COG0057 40041008981 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846 40041008982 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 40041008983 HMMPfam hit to PF02800, Glyceraldehyde 3-phosphate dehydrogenase, score 1.8e-98 40041008984 PS00071 Glyceraldehyde 3-phosphate dehydrogenase active site. 40041008985 HMMPfam hit to PF00044, Glyceraldehyde 3-phosphate dehydrogenase, score 3.1e-80 40041008986 elongation factor G; Reviewed; Region: PRK00007 40041008987 Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886 40041008988 G1 box; other site 40041008989 putative GEF interaction site [polypeptide binding]; other site 40041008990 GTP/Mg2+ binding site [chemical binding]; other site 40041008991 Switch I region; other site 40041008992 G2 box; other site 40041008993 G3 box; other site 40041008994 Switch II region; other site 40041008995 G4 box; other site 40041008996 G5 box; other site 40041008997 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 40041008998 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 40041008999 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 40041009000 HMMPfam hit to PF00679, Translation elongation factor EFG/EF2, C-terminal, score 1e-46 40041009001 HMMPfam hit to PF03764, Translation elongation factor EFG/EF2, domain IV, score 5.7e-67 40041009002 HMMPfam hit to PF03144, Translation elongation factor EFTu/EF1A, domain 2, score 2.3e-18 40041009003 HMMPfam hit to PF00009, Protein synthesis factor, GTP-binding, score 7.2e-113 40041009004 PS00301 GTP-binding elongation factors signature. 40041009005 PS00017 ATP/GTP-binding site motif A (P-loop). 40041009006 30S ribosomal protein S7; Validated; Region: PRK05302 40041009007 HMMPfam hit to PF00177, Ribosomal protein S7, score 2e-81 40041009008 PS00052 Ribosomal protein S7 signature. 40041009009 S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368 40041009010 S17 interaction site [polypeptide binding]; other site 40041009011 S8 interaction site; other site 40041009012 16S rRNA interaction site [nucleotide binding]; other site 40041009013 streptomycin interaction site [chemical binding]; other site 40041009014 23S rRNA interaction site [nucleotide binding]; other site 40041009015 aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site 40041009016 HMMPfam hit to PF00164, Ribosomal protein S12/S23, score 1e-64 40041009017 PS00055 Ribosomal protein S12 signature. 40041009018 Helix-turn-helix domain; Region: HTH_28; pfam13518 40041009019 Winged helix-turn helix; Region: HTH_29; pfam13551 40041009020 Homeodomain-like domain; Region: HTH_32; pfam13565 40041009021 Integrase core domain; Region: rve; pfam00665 40041009022 PS00017 ATP/GTP-binding site motif A (P-loop). 40041009023 HMMPfam hit to PF00665, Integrase, catalytic core, score 1.1e-18 40041009024 SEC10/PgrA surface exclusion domain; Region: Surf_Exclu_PgrA; TIGR04320 40041009025 pur operon repressor; Provisional; Region: PRK09213 40041009026 Bacterial purine repressor, N-terminal; Region: PuR_N; pfam09182 40041009027 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 40041009028 active site 40041009029 HMMPfam hit to PF00156, Phosphoribosyltransferase, score 2.2e-17 40041009030 HMMPfam hit to PF09182, Bacterial purine repressor, N-terminal, score 1.9e-39 40041009031 Predicted HD-superfamily hydrolase [General function prediction only]; Region: COG3481 40041009032 YhaM_OBF_like: A subfamily of OB folds similar to that found in Bacillus subtilis YhaM and Staphylococcus aureus cmp-binding factor-1 (SaCBF1). Both these proteins are 3'-to-5'exoribonucleases. YhaM requires Mn2+ or Co2+ for activity and is...; Region: YhaM_OBF_like; cd04492 40041009033 generic binding surface II; other site 40041009034 generic binding surface I; other site 40041009035 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 40041009036 Zn2+ binding site [ion binding]; other site 40041009037 Mg2+ binding site [ion binding]; other site 40041009038 HMMPfam hit to PF01966, Metal-dependent phosphohydrolase, HD region, subdomain, score 3e-05 40041009039 HMMPfam hit to PF01336, Nucleic acid binding, OB-fold, tRNA/helicase-type, score 0.0057 40041009040 Predicted nuclease of restriction endonuclease-like fold, RmuC family [General function prediction only]; Region: COG1322 40041009041 RmuC family; Region: RmuC; pfam02646 40041009042 HMMPfam hit to PF02646, RmuC, score 5.3e-137 40041009043 1 probable transmembrane helix predicted for SZO16960 by TMHMM2.0 at aa 3-22 40041009044 Thiamine pyrophosphokinase [Coenzyme metabolism]; Region: THI80; COG1564 40041009045 Thiamine pyrophosphokinase; Region: TPK; cd07995 40041009046 active site 40041009047 dimerization interface [polypeptide binding]; other site 40041009048 thiamine binding site [chemical binding]; other site 40041009049 HMMPfam hit to PF04265, Thiamin pyrophosphokinase, vitamin B1-binding region, score 2.6e-18 40041009050 HMMPfam hit to PF04263, Thiamin pyrophosphokinase, catalytic region, score 5.7e-43 40041009051 Pentose-5-phosphate-3-epimerase [Carbohydrate transport and metabolism]; Region: Rpe; COG0036 40041009052 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 40041009053 substrate binding site [chemical binding]; other site 40041009054 hexamer interface [polypeptide binding]; other site 40041009055 metal binding site [ion binding]; metal-binding site 40041009056 HMMPfam hit to PF00834, Ribulose-phosphate 3-epimerase, score 7.9e-104 40041009057 PS01086 Ribulose-phosphate 3-epimerase family signature 2. 40041009058 PS01085 Ribulose-phosphate 3-epimerase family signature 1. 40041009059 GTPase RsgA; Reviewed; Region: PRK00098 40041009060 S1_YloQ_GTPase: YloQ GTase family (also known as YjeQ and CpgA), S1-like RNA-binding domain. Proteins in the YloQ GTase family bind the ribosome and have GTPase activity. The precise role of this family is unknown. The protein structure is composed of...; Region: S1_YloQ_GTPase; cd04466 40041009061 RNA binding site [nucleotide binding]; other site 40041009062 homodimer interface [polypeptide binding]; other site 40041009063 Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854 40041009064 GTPase/Zn-binding domain interface [polypeptide binding]; other site 40041009065 GTP/Mg2+ binding site [chemical binding]; other site 40041009066 G4 box; other site 40041009067 G1 box; other site 40041009068 Switch I region; other site 40041009069 G2 box; other site 40041009070 G3 box; other site 40041009071 Switch II region; other site 40041009072 HMMPfam hit to PF03193, GTPase EngC, score 2.5e-152 40041009073 PS00017 ATP/GTP-binding site motif A (P-loop). 40041009074 16S ribosomal RNA methyltransferase KsgA/Dim1 family protein; Reviewed; Region: ksgA; PRK00274 40041009075 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 40041009076 S-adenosylmethionine binding site [chemical binding]; other site 40041009077 HMMPfam hit to PF00398, Ribosomal RNA adenine methylase transferase, score 7.9e-77 40041009078 PS01131 Ribosomal RNA adenine dimethylases signature. 40041009079 ribonuclease M5; Region: 5S_RNA_mat_M5; TIGR00334 40041009080 TOPRIM_ RNase M5_like: The topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain found in Ribonuclease M5: (RNase M5) and other small primase-like proteins from bacteria and archaea. RNase M5 catalyzes the maturation of 5S rRNA in low...; Region: TOPRIM_RNase_M5_like; cd01027 40041009081 putative active site [active] 40041009082 putative metal binding site [ion binding]; other site 40041009083 Domain of unknown function (DUF4093); Region: DUF4093; pfam13331 40041009084 HMMPfam hit to PF01751, TOPRIM, score 9.5e-07 40041009085 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 40041009086 Predicted metal-dependent hydrolases with the TIM-barrel fold [General function prediction only]; Region: COG1099 40041009087 active site 40041009088 HMMPfam hit to PF01026, Deoxyribonuclease, TatD-related, score 4.1e-122 40041009089 PS01091 Uncharacterized protein family UPF0006 signature 3. 40041009090 PS01137 Uncharacterized protein family UPF0006 signature 1. 40041009091 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 40041009092 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 40041009093 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 40041009094 putative active site [active] 40041009095 HMMPfam hit to PF01418, Helix-turn-helix protein RpiR, score 6.9e-06 40041009096 HMMPfam hit to PF01380, Sugar isomerase (SIS), score 2.1e-12 40041009097 Acetyl xylan esterase (AXE1); Region: AXE1; pfam05448 40041009098 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 40041009099 HMMPfam hit to PF05448, Acetyl xylan esterase, score 2.5e-161 40041009100 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 40041009101 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 40041009102 nucleotide binding site [chemical binding]; other site 40041009103 HMMPfam hit to PF00480, ROK, score 1.4e-31 40041009104 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 40041009105 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 40041009106 Class I aldolases; Region: Aldolase_Class_I; cl17187 40041009107 catalytic residue [active] 40041009108 HMMPfam hit to PF00701, Dihydrodipicolinate synthetase, score 1.3e-36 40041009109 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 40041009110 Protein of unknown function, DUF624; Region: DUF624; pfam04854 40041009111 5 probable transmembrane helices predicted for SZO17070 by TMHMM2.0 at aa 26-48, 83-105, 117-139, 154-176 and 183-205 40041009112 HMMPfam hit to PF04854, Protein of unknown function DUF624, score 1.6e-08 40041009113 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 40041009114 Domain of unknown function (DUF386); Region: DUF386; cl01047 40041009115 HMMPfam hit to PF04074, Conserved hypothetical protein CHP00022, score 1.4e-39 40041009116 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 40041009117 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 40041009118 dimer interface [polypeptide binding]; other site 40041009119 conserved gate region; other site 40041009120 putative PBP binding loops; other site 40041009121 ABC-ATPase subunit interface; other site 40041009122 HMMPfam hit to PF00528, Binding-protein-dependent transport systems inner membrane component, score 7.5e-25 40041009123 6 probable transmembrane helices predicted for SZO17090 by TMHMM2.0 at aa 12-34, 76-98, 107-129, 134-156, 182-204 and 239-261 40041009124 PS00430 TonB-dependent receptor proteins signature 1. 40041009125 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 40041009126 dimer interface [polypeptide binding]; other site 40041009127 conserved gate region; other site 40041009128 putative PBP binding loops; other site 40041009129 ABC-ATPase subunit interface; other site 40041009130 HMMPfam hit to PF00528, Binding-protein-dependent transport systems inner membrane component, score 4.7e-14 40041009131 5 probable transmembrane helices predicted for SZO17100 by TMHMM2.0 at aa 12-34, 70-92, 105-127, 158-180 and 264-286 40041009132 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 40041009133 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 40041009134 HMMPfam hit to PF01547, Bacterial extracellular solute-binding protein, family 1, score 6.4e-28 40041009135 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 40041009136 N-acetylmannosamine-6-phosphate epimerase (NanE) converts N-acetylmannosamine-6-phosphate to N-acetylglucosamine-6-phosphate. This reaction is part of the pathway that allows the usage of sialic acid as a carbohydrate source. Sialic acids are a family of...; Region: NanE; cd04729 40041009137 N-acetylmannosamine-6-phosphate 2-epimerase; Provisional; Region: PRK01130 40041009138 putative active site cavity [active] 40041009139 HMMPfam hit to PF04131, N-acetylmannosamine-6-phosphate epimerase, score 5.7e-124 40041009140 50S ribosomal protein L34; Reviewed; Region: rpmH; PRK00399 40041009141 HMMPfam hit to PF00468, Ribosomal protein L34, score 1.1e-18 40041009142 PS00784 Ribosomal protein L34 signature. 40041009143 Phosphotransferase system IIA components [Carbohydrate transport and metabolism]; Region: NagE; COG2190 40041009144 HPr interaction site; other site 40041009145 glycerol kinase (GK) interaction site [polypeptide binding]; other site 40041009146 active site 40041009147 phosphorylation site [posttranslational modification] 40041009148 HMMPfam hit to PF00358, Phosphotransferase system, sugar-specific permease EIIA 1 domain, score 1.3e-49 40041009149 PS00371 PTS EIIA domains phosphorylation site signature 1. 40041009150 PTS system, glucose-specific IIBC component; Region: PTS-II-BC-glcB; TIGR02002 40041009151 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 40041009152 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cl00164 40041009153 active site turn [active] 40041009154 phosphorylation site [posttranslational modification] 40041009155 HMMPfam hit to PF00367, Phosphotransferase system, EIIB, score 5.5e-14 40041009156 PS01035 PTS EIIB domains cysteine phosphorylation site signature. 40041009157 10 probable transmembrane helices predicted for SZO17150 by TMHMM2.0 at aa 12-34, 49-81, 88-110, 115-134, 155-177, 192-214, 263-285, 315-337, 344-366 and 371-393 40041009158 HMMPfam hit to PF02378, Phosphotransferase system, EIIC, score 2.1e-95 40041009159 N-acetylmannosamine-6-phosphate epimerase (NanE) converts N-acetylmannosamine-6-phosphate to N-acetylglucosamine-6-phosphate. This reaction is part of the pathway that allows the usage of sialic acid as a carbohydrate source. Sialic acids are a family of...; Region: NanE; cd04729 40041009160 N-acetylmannosamine-6-phosphate 2-epimerase; Provisional; Region: PRK01130 40041009161 putative active site cavity [active] 40041009162 HMMPfam hit to PF04131, N-acetylmannosamine-6-phosphate epimerase, score 1.1e-124 40041009163 RNA recognition motif (RRM) superfamily; Region: RRM_SF; cl17169 40041009164 Protein of unknown function (DUF4237); Region: DUF4237; pfam14021 40041009165 Protein of unknown function (DUF4237); Region: DUF4237; pfam14021 40041009166 Probable gene remnant. Similar to an internal region of Peptostreptococcus micros ATCC 33270 uncharacterized protein. UniProt:A8SJH0 (EMBL:ABEE02000015) (552 aa) fasta scores: E()=1.6e-22, 41.2% id in 194 aa 40041009167 1 probable transmembrane helix predicted for SZO17290 by TMHMM2.0 at aa 5-27 40041009168 LXG domain of WXG superfamily; Region: LXG; pfam04740 40041009169 Protein of unknown function (DUF4237); Region: DUF4237; pfam14021 40041009171 Predicted RNA-binding protein [General function prediction only]; Region: Jag; COG1847 40041009172 jag_K homology RNA-binding domain. The KH domain is found in proteins homologous to the Bacillus subtilis protein Jag, which is associated with SpoIIIJ and is necessary for the third stage of sporulation. The KH motif is a beta-alpha-alpha-beta-beta...; Region: jag_KH; cd02414 40041009173 G-X-X-G motif; other site 40041009174 R3H domain found in proteins homologous to Bacillus subtilus Jag, which is associated with SpoIIIJ. SpoIIIJ is necessary for the third stage of sporulation. The name of the R3H domain comes from the characteristic spacing of the most conserved arginine...; Region: R3H_jag; cd02644 40041009175 RxxxH motif; other site 40041009176 HMMPfam hit to PF01424, Single-stranded nucleic acid binding R3H, score 1.6e-11 40041009177 Preprotein translocase subunit YidC [Intracellular trafficking and secretion]; Region: YidC; COG0706 40041009178 membrane protein insertase, YidC/Oxa1 family, C-terminal domain; Region: yidC_oxa1_cterm; TIGR03592 40041009179 HMMPfam hit to PF02096, 60 kDa inner membrane insertion protein, score 1.6e-55 40041009180 5 probable transmembrane helices predicted for SZO17350 by TMHMM2.0 at aa 13-32, 52-74, 129-151, 171-193 and 206-228 40041009181 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 40041009182 ribonuclease P; Reviewed; Region: rnpA; PRK00499 40041009183 HMMPfam hit to PF00825, Bacterial ribonuclease P protein, score 3.4e-28 40041009184 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 40041009185 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 40041009186 active site 40041009187 phosphorylation site [posttranslational modification] 40041009188 intermolecular recognition site; other site 40041009189 dimerization interface [polypeptide binding]; other site 40041009190 LytTr DNA-binding domain; Region: LytTR; pfam04397 40041009191 HMMPfam hit to PF04397, LytTr DNA-binding region, score 8.5e-26 40041009192 HMMPfam hit to PF00072, Response regulator receiver, score 2.6e-09 40041009193 Predicted signal transduction protein with a C-terminal ATPase domain [Signal transduction mechanisms]; Region: COG2972 40041009194 6 probable transmembrane helices predicted for SZO17380 by TMHMM2.0 at aa 7-29, 39-61, 74-96, 111-133, 150-172 and 182-199 40041009195 Predicted signal transduction protein with a C-terminal ATPase domain [Signal transduction mechanisms]; Region: COG2972 40041009196 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 40041009197 ATP binding site [chemical binding]; other site 40041009198 Mg2+ binding site [ion binding]; other site 40041009199 G-X-G motif; other site 40041009200 HMMPfam hit to PF02518, ATP-binding region, ATPase-like, score 5.8e-10 40041009201 6 probable transmembrane helices predicted for SZO17390 by TMHMM2.0 at aa 5-27, 45-67, 79-101, 116-138, 155-177 and 187-209 40041009202 glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406 40041009203 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 40041009204 active site 40041009205 HIGH motif; other site 40041009206 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 40041009207 active site 40041009208 KMSKS motif; other site 40041009209 HMMPfam hit to PF00749, Glutamyl/glutaminyl-tRNA synthetase, class Ic, score 1.4e-157 40041009210 PS00178 Aminoacyl-transfer RNA synthetases class-I signature. 40041009211 Uncharacterized conserved protein [Function unknown]; Region: COG2013 40041009212 HMMPfam hit to PF01987, Protein of unknown function DUF124, score 1.9e-84 40041009213 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeD; cd03379 40041009214 active site clefts [active] 40041009215 zinc binding site [ion binding]; other site 40041009216 dimer interface [polypeptide binding]; other site 40041009217 HMMPfam hit to PF00484, Carbonic anhydrase, score 1.2e-13 40041009218 DNA repair protein RadA; Provisional; Region: PRK11823 40041009219 Sms (bacterial radA) DNA repair protein. This protein is not related to archael radA any more than is to other RecA-like NTPases. Sms has a role in recombination and recombinational repair and is responsible for the stabilization or processing of...; Region: Sms; cd01121 40041009220 Walker A motif/ATP binding site; other site 40041009221 ATP binding site [chemical binding]; other site 40041009222 Walker B motif; other site 40041009223 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 40041009224 PS00017 ATP/GTP-binding site motif A (P-loop). 40041009225 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 40041009226 trimer interface [polypeptide binding]; other site 40041009227 active site 40041009228 HMMPfam hit to PF00692, DeoxyUTP pyrophosphatase, score 1.8e-16 40041009229 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1636 40041009230 HMMPfam hit to PF02677, Protein of unknown function DUF208, score 7.3e-49 40041009231 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 40041009232 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 40041009233 ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251 40041009234 Walker A/P-loop; other site 40041009235 ATP binding site [chemical binding]; other site 40041009236 Q-loop/lid; other site 40041009237 ABC transporter signature motif; other site 40041009238 Walker B; other site 40041009239 D-loop; other site 40041009240 H-loop/switch region; other site 40041009241 HMMPfam hit to PF00005, ABC transporter related, score 3.1e-55 40041009242 PS00017 ATP/GTP-binding site motif A (P-loop). 40041009243 HMMPfam hit to PF00664, ABC transporter, transmembrane region, score 1e-27 40041009244 5 probable transmembrane helices predicted for SZO17470 by TMHMM2.0 at aa 16-33, 82-104, 154-173, 178-200 and 257-279 40041009245 PS00046 Histone H2A signature. 40041009246 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 40041009247 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 40041009248 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 40041009249 Walker A/P-loop; other site 40041009250 ATP binding site [chemical binding]; other site 40041009251 Q-loop/lid; other site 40041009252 ABC transporter signature motif; other site 40041009253 Walker B; other site 40041009254 D-loop; other site 40041009255 H-loop/switch region; other site 40041009256 HMMPfam hit to PF00005, ABC transporter related, score 3.1e-49 40041009257 PS00211 ABC transporters family signature. 40041009258 PS00017 ATP/GTP-binding site motif A (P-loop). 40041009259 7 probable transmembrane helices predicted for SZO17480 by TMHMM2.0 at aa 12-34, 52-74, 95-114, 124-146, 153-175, 235-257 and 264-286 40041009260 HMMPfam hit to PF00664, ABC transporter, transmembrane region, score 5e-22 40041009261 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 40041009262 MarR family; Region: MarR_2; pfam12802 40041009263 HMMPfam hit to PF01047, Bacterial regulatory protein, MarR, score 8.6e-15 40041009264 NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094 40041009265 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 40041009266 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479 40041009267 HMMPfam hit to PF01210, NAD-dependent glycerol-3-phosphate dehydrogenase, N-terminal, score 1.5e-83 40041009268 HMMPfam hit to PF07479, NAD-dependent glycerol-3-phosphate dehydrogenase, C-terminal, score 4.1e-71 40041009269 Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541 40041009270 dTDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: RfbA; COG1209 40041009271 active site 40041009272 tetramer interface; other site 40041009273 HMMPfam hit to PF00483, Nucleotidyl transferase, score 1.2e-19 40041009274 Rhomboid family; Region: Rhomboid; pfam01694 40041009275 6 probable transmembrane helices predicted for SZO17520 by TMHMM2.0 at aa 12-34, 61-83, 96-115, 119-141, 162-184 and 204-226 40041009276 HMMPfam hit to PF01694, Peptidase S54, rhomboid, score 3.5e-34 40041009277 5-formyltetrahydrofolate cyclo-ligase family; Region: 5-FTHF_cyc-lig; pfam01812 40041009278 5-formyltetrahydrofolate cyclo-ligase [Coenzyme metabolism]; Region: COG0212; cl00360 40041009279 HMMPfam hit to PF01812, 5-formyltetrahydrofolate cyclo-ligase, score 1.2e-45 40041009280 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 40041009281 Gram positive anchor; Region: Gram_pos_anchor; pfam00746 40041009282 1 probable transmembrane helix predicted for SZO17540 by TMHMM2.0 at aa 48-70 40041009283 HMMPfam hit to PF01391, Collagen triple helix repeat, score 5.3e-15 40041009284 HMMPfam hit to PF00746, Surface protein from Gram-positive cocci, anchor region, score 1.6e-08 40041009285 PS00343 Gram-positive cocci surface proteins 'anchoring' hexapeptide. 40041009286 RloB-like protein; Region: RloB; pfam13707 40041009287 ICESz2 40041009288 Probable gene remnant. Similar to an internal region of Enterococcus faecalis (Streptococcus faecalis) relaxase. UniProt:Q82YL3 (EMBL:AE016831) (561 aa) fasta scores: E()=7.1e-19, 50.746% id in 134 aa 40041009289 CDS contains a nonsense mutation (opal) after codon 573. Similar to Lactococcus lactis subsp. cremoris (strain MG1363) ltra group II intron-encoded protein LtrA [includes: reverse-transcriptase. UniProt:P0A3U1 (EMBL:X89922) (599 aa) fasta scores: E()=3.3e-194, 74.167% id in 600 aa 40041009290 HMMPfam hit to PF01348, Intron maturase, type II, score 6.9e-39 40041009291 HMMPfam hit to PF00078, RNA-directed DNA polymerase (reverse transcriptase), score 4.8e-74 40041009292 Probable gene remnant. Similar to the N-terminal region of Streptococcus macedonicus relaxase. UniProt:A6MEQ6 (EMBL:DQ835394) (621 aa) fasta scores: E()=8.9e-51, 95.4% id in 131 aa 40041009293 HMMPfam hit to PF03432, Endonuclease relaxase, MobA/VirD2, score 2.2e-35 40041009294 HMMPfam hit to PF05713, Bacterial mobilisation, score 3.3e-11 40041009295 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 40041009296 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 40041009297 Walker A motif; other site 40041009298 ATP binding site [chemical binding]; other site 40041009299 Walker B motif; other site 40041009300 arginine finger; other site 40041009301 HMMPfam hit to PF00004, AAA ATPase, core, score 2.6e-51 40041009302 PS00017 ATP/GTP-binding site motif A (P-loop). 40041009303 Predicted helix-turn-helix motif with score 1472.000, SD 4.20 at aa 351-372, sequence FSLQTIADILGSSKTTIQKMVK 40041009304 Subtilisin-like serine proteases [Posttranslational modification, protein turnover, chaperones]; Region: AprE; COG1404 40041009305 Peptidase S8 family domain in Subtilisin-like proteins; Region: Peptidases_S8_Subtilisin_like_2; cd04847 40041009306 active site 40041009307 catalytic triad [active] 40041009308 CDS contains a frameshift after codon 181. Similar to Streptococcus agalactiae serotype III. Streptococcus agalactiae serotype III uncharacterized protein gbs1348. uncharacterized protein gbs1348. UniProt:Q8E4Q3 (EMBL:AL766850) (361 aa) fasta scores: E()=1.8e-120, 79.834% id in 362 aa 40041009309 HMMPfam hit to PF08275, DNA primase catalytic core, N-terminal, score 3.3e-05 40041009310 Predicted helix-turn-helix motif with score 995.000, SD 2.58 at aa 194-215, sequence LSYAKLSDKLLVNQVTIWNGKL 40041009311 1 probable transmembrane helix predicted for SZO17680 by TMHMM2.0 at aa 38-60 40041009312 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 40041009313 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 40041009314 11 probable transmembrane helices predicted for SZO17690 by TMHMM2.0 at aa 12-34, 44-66, 87-109, 124-146, 159-181, 186-208, 250-272, 304-326, 333-350, 365-387 and 392-414 40041009315 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 40041009316 HMMPfam hit to PF01554, Multi antimicrobial extrusion protein MatE, score 3.9e-09 40041009317 Coenzyme PQQ synthesis protein D (PqqD); Region: PqqD; cl05126 40041009318 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 40041009319 putative heme d1 biosynthesis radical SAM protein NirJ2; Region: rSAM_NirJ2; TIGR04055 40041009320 FeS/SAM binding site; other site 40041009321 radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085 40041009322 HMMPfam hit to PF04055, Radical SAM, score 6.3e-18 40041009323 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 40041009324 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 40041009325 non-specific DNA binding site [nucleotide binding]; other site 40041009326 salt bridge; other site 40041009327 sequence-specific DNA binding site [nucleotide binding]; other site 40041009328 transcriptional activator, Rgg/GadR/MutR family, C-terminal domain; Region: RGG_Cterm; TIGR01716 40041009329 HMMPfam hit to PF01381, Helix-turn-helix type 3, score 4.2e-10 40041009330 3 probable transmembrane helices predicted for SZO17740 by TMHMM2.0 at aa 5-22, 29-51 and 61-83 40041009331 Methyltransferase domain; Region: Methyltransf_26; pfam13659 40041009332 DNA methylase [Transcription / DNA replication, recombination, and repair]; Region: COG4646 40041009333 SNF2 family N-terminal domain; Region: SNF2_N; pfam00176 40041009334 DNA methylase [Transcription / DNA replication, recombination, and repair]; Region: COG4646 40041009335 helicase superfamily c-terminal domain; Region: HELICc; smart00490 40041009336 HMMPfam hit to PF00271, DNA/RNA helicase, C-terminal, score 0.0018 40041009337 RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651 40041009338 Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078 40041009339 putative active site [active] 40041009340 putative NTP binding site [chemical binding]; other site 40041009341 putative nucleic acid binding site [nucleotide binding]; other site 40041009342 Type II intron maturase; Region: Intron_maturas2; pfam01348 40041009343 PS00190 Cytochrome c family heme-binding site signature. 40041009344 HMMPfam hit to PF01348, Intron maturase, type II, score 7.5e-08 40041009345 HMMPfam hit to PF00078, RNA-directed DNA polymerase (reverse transcriptase), score 5.2e-67 40041009346 HMMPfam hit to PF04851, Restriction endonuclease, type I, R subunit/Type III, Res subunit, score 9.5e-10 40041009347 HMMPfam hit to PF08241, Methyltransferase type 11, score 5.3e-07 40041009348 putative cross-wall-targeting lipoprotein signal; Region: strep_RK_lipo; TIGR03726 40041009349 Glucan-binding protein C; Region: GbpC; pfam08363 40041009350 HMMPfam hit to PF08363, Glucan-binding protein C, score 3.2e-108 40041009351 Nucleotidyl transferase of unknown function (DUF1814); Region: DUF1814; pfam08843 40041009352 HMMPfam hit to PF08843, Protein of unknown function DUF1814, score 1e-28 40041009353 Domain of unknown function (DUF4095); Region: DUF4095; pfam13338 40041009354 Probable gene remnant. 40041009355 HMMPfam hit to PF05257, Cysteine, histidine-dependent amidohydrolase/peptidase, score 3.1e-12 40041009356 Probable gene remnant. Similar to the N-terminal region of Streptococcus agalactiae H36B Tn5252 orf28 UniProt:Q3D1J2 (EMBL:AAJS01000027) (933 aa) fasta scores: E()=4.2e-181, 70.7% id in 663 aa 40041009357 HMMPfam hit to PF01551, Peptidase M23B, score 0.00037 40041009358 N-terminal domain of reverse transcriptase; Region: RVT_N; pfam13655 40041009359 Retron-type reverse transcriptase [DNA replication, recombination, and repair]; Region: COG3344 40041009360 RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651 40041009361 putative active site [active] 40041009362 putative NTP binding site [chemical binding]; other site 40041009363 putative nucleic acid binding site [nucleotide binding]; other site 40041009364 Group II intron, maturase-specific domain; Region: GIIM; pfam08388 40041009365 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 40041009366 active site 40041009367 HMMPfam hit to PF08388, Group II intron, maturase-specific, score 6.8e-25 40041009368 HMMPfam hit to PF00078, RNA-directed DNA polymerase (reverse transcriptase), score 3e-52 40041009369 CDS contains an internal deletion in comparison to orthologues. Similar to Streptococcus agalactiae serotype III uncharacterized protein gbs1361. UniProt:Q8E4P0 (EMBL:AL766850) (117 aa) fasta scores: E()=2.8e-16, 65.0% id in 117 aa 40041009370 1 probable transmembrane helix predicted for SZO17890 by TMHMM2.0 at aa 29-51 40041009371 7 probable transmembrane helices predicted for SZO17900 by TMHMM2.0 at aa 51-73, 86-108, 113-135, 148-170, 180-202, 215-237 and 252-274 40041009372 2 probable transmembrane helices predicted for SZO17910 by TMHMM2.0 at aa 22-44 and 57-79 40041009373 HMMPfam hit to PF02534, TRAG protein, score 5.3e-26 40041009374 HMMPfam hit to PF02534, TRAG protein, score 2.1e-10 40041009375 2 probable transmembrane helices predicted for SZO17930 by TMHMM2.0 at aa 7-26 and 65-82 40041009376 CAAX protease self-immunity; Region: Abi; pfam02517 40041009377 HMMPfam hit to PF02517, Abortive infection protein, score 2.2e-07 40041009378 6 probable transmembrane helices predicted for SZO17950 by TMHMM2.0 at aa 5-27, 31-50, 63-85, 95-117, 124-146 and 151-168 40041009379 Probable gene remnant. Similar to the C-terminal region of Streptococcus agalactiae serotype III uncharacterized protein gbs1368. UniProt:Q8E4N3 (EMBL:AL766850) (128 aa) fasta scores: E()=9.9e-21, 61.538% id in 91 aa 40041009380 Probable gene remnant. Similar to the N-terminal region of Streptococcus agalactiae serotype III uncharacterized protein gbs1369. UniProt:Q8E4N2 (EMBL:AL766850) (148 aa) fasta scores: E()=1.3e-32, 68.1% id in 119 aa 40041009381 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315 40041009382 cofactor binding site; other site 40041009383 DNA binding site [nucleotide binding] 40041009384 substrate interaction site [chemical binding]; other site 40041009385 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315 40041009386 HMMPfam hit to PF00145, C-5 cytosine-specific DNA methylase, score 1.5e-18 40041009387 HMMPfam hit to PF00145, C-5 cytosine-specific DNA methylase, score 6.2e-79 40041009388 PS00094 C-5 cytosine-specific DNA methylases active site. 40041009389 Replication initiator protein A (RepA) N-terminus; Region: RepA_N; pfam06970 40041009390 HMMPfam hit to PF06970, Replication initiator A, N-terminal, score 1.6e-41 40041009391 Probable gene remnant. Similar to the C-terminal region of Streptococcus mutans transposase UniProt:Q8DTH7 (EMBL:AE014133) (93 aa) fasta scores: E()=6.4e-15, 84.0% id in 50 aa 40041009392 HMMPfam hit to PF01797, Transposase IS200-like, score 5e-08 40041009393 Probable gene remnant. Similar to the N-terminal region of Lactobacillus salivarius subsp. salivarius (strain UCC118) transposase islasa3a, is200 family. UniProt:Q1WVQ5 (EMBL:CP000233) (155 aa) fasta scores: E()=2.7e-12, 67.9% id in 53 aa 40041009394 HMMPfam hit to PF01797, Transposase IS200-like, score 2.2e-11 40041009395 Probable gene remnant. CDS is truncated by the insertion of the an downstream integrative conjugative element and subsequent recombination events. C-terminal region of complete CDS is SZO01811 40041009396 ASC-1 homology domain, subfamily similar to Pyrococcus furiosus Pf0470. The ASCH domain, a small beta-barrel domain found in all three kingdoms of life, resembles the RNA-binding PUA domain and may also interact with RNA. ASCH has been proposed to...; Region: ASCH_PF0470_like; cd06555 40041009397 HMMPfam hit to PF07060, ProFAR isomerase-like, score 1e-16 40041009398 Protein of unknown function (DUF3013); Region: DUF3013; pfam11217 40041009399 aminodeoxychorismate synthase; Provisional; Region: PRK07508 40041009400 chorismate binding enzyme; Region: Chorismate_bind; cl10555 40041009401 PyridoxaL 5'-Phosphate Dependent Enzymes class IV (PLPDE_IV). This D-amino acid superfamily, one of five classes of PLPDE, consists of branched-chain amino acid aminotransferases (BCAT), D-amino acid transferases (DAAT), and...; Region: PLPDE_IV; cl00224 40041009402 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 40041009403 substrate-cofactor binding pocket; other site 40041009404 pyridoxal 5'-phosphate binding site [chemical binding]; other site 40041009405 catalytic residue [active] 40041009406 HMMPfam hit to PF00425, Chorismate binding, C-terminal, score 1.4e-68 40041009407 PS00770 Aminotransferases class-IV signature. 40041009408 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 40041009409 Glutamine amidotransferase class-I; Region: GATase; pfam00117 40041009410 glutamine binding [chemical binding]; other site 40041009411 catalytic triad [active] 40041009412 HMMPfam hit to PF00117, Glutamine amidotransferase class-I, score 2.4e-66 40041009413 PS00442 Glutamine amidotransferases class-I active site. 40041009414 recombination factor protein RarA; Reviewed; Region: PRK13342 40041009415 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 40041009416 Walker A motif; other site 40041009417 ATP binding site [chemical binding]; other site 40041009418 Walker B motif; other site 40041009419 arginine finger; other site 40041009420 MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002 40041009421 HMMPfam hit to PF00004, AAA ATPase, core, score 1.5e-21 40041009422 PS00017 ATP/GTP-binding site motif A (P-loop). 40041009423 topology modulation protein; Provisional; Region: PRK07261 40041009424 AAA domain; Region: AAA_17; pfam13207 40041009425 PS00017 ATP/GTP-binding site motif A (P-loop). 40041009426 PS00290 Immunoglobulins and major histocompatibility complex proteins signature. 40041009427 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 40041009428 HMMPfam hit to PF00746, Surface protein from Gram-positive cocci, anchor region, score 4.5e-11 40041009429 PS00343 Gram-positive cocci surface proteins 'anchoring' hexapeptide. 40041009430 Gram positive anchor; Region: Gram_pos_anchor; pfam00746 40041009431 HMMPfam hit to PF00746, Surface protein from Gram-positive cocci, anchor region, score 8.1e-11 40041009432 PS00343 Gram-positive cocci surface proteins 'anchoring' hexapeptide. 40041009433 HMMPfam hit to PF01391, Collagen triple helix repeat, score 4.7e-14 40041009434 1 probable transmembrane helix predicted for SZO18110 by TMHMM2.0 at aa 13-35 40041009435 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 40041009436 catalytic core [active] 40041009437 HMMPfam hit to PF00300, Phosphoglycerate mutase, score 8.4e-34 40041009438 Microcin C7 self-immunity protein determines resistance to exogenous microcin C7; Region: Peptidase_S66_mccF_like; cd07062 40041009439 putative dimer interface [polypeptide binding]; other site 40041009440 catalytic triad [active] 40041009441 HMMPfam hit to PF02016, Peptidase S66, LD-carboxypeptidase A, score 6e-41 40041009442 PS00308 Legume lectins alpha-chain signature. 40041009443 Transposase [DNA replication, recombination, and repair]; Region: COG5421 40041009444 Transposase [DNA replication, recombination, and repair]; Region: COG5421 40041009445 Glycerol dehydrogenase and related enzymes [Energy production and conversion]; Region: GldA; COG0371 40041009446 Glycerol dehydrogenases (GlyDH) catalyzes oxidation of glycerol to dihydroxyacetone in glycerol dissmilation; Region: GlyDH; cd08170 40041009447 dimer interface [polypeptide binding]; other site 40041009448 active site 40041009449 metal binding site [ion binding]; metal-binding site 40041009450 HMMPfam hit to PF00465, Iron-containing alcohol dehydrogenase, score 2.6e-79 40041009451 Transaldolase-like fructose-6-phosphate aldolases (FSA) found in bacteria and archaea; Region: Transaldolase_FSA; cd00956 40041009452 active site 40041009453 intersubunit interactions; other site 40041009454 catalytic residue [active] 40041009455 HMMPfam hit to PF00923, Transaldolase, score 1.8e-26 40041009456 PS00958 Transaldolase active site. 40041009457 Pyruvate-formate lyase [Energy production and conversion]; Region: PflD; COG1882 40041009458 Pyruvate formate lyase 2 and related enzymes; Region: PFL2_DhaB_BssA; cd01677 40041009459 dimer interface [polypeptide binding]; other site 40041009460 active site 40041009461 glycine loop; other site 40041009462 HMMPfam hit to PF01228, Formate C-acetyltransferase glycine radical, score 3.3e-22 40041009463 PS00850 Glycine radical signature. 40041009464 HMMPfam hit to PF02901, Pyruvate formate-lyase, PFL, score 1e-181 40041009465 PS00063 Aldo/keto reductase family active site signature. 40041009466 Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455 40041009467 cellobiose phosphotransferase system IIC component; Reviewed; Region: celD; PRK09592 40041009468 10 probable transmembrane helices predicted for SZO18180 by TMHMM2.0 at aa 28-50, 70-92, 101-120, 135-157, 186-208, 223-245, 288-310, 347-369, 374-396 and 400-417 40041009469 HMMPfam hit to PF02378, Phosphotransferase system, EIIC, score 1.1e-103 40041009470 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 40041009471 PTS_IIB_chitobiose_lichenan: subunit IIB of enzyme II (EII) of the N,N-diacetylchitobiose-specific and lichenan-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In these systems, EII is either a lichenan- or an N; Region: PTS_IIB_chitobiose_lichenan; cd05564 40041009472 active site 40041009473 P-loop; other site 40041009474 phosphorylation site [posttranslational modification] 40041009475 HMMPfam hit to PF02302, Phosphotransferase system, lactose/cellobiose-specific IIB subunit, score 3.5e-39 40041009476 PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_lac; cd00215 40041009477 active site 40041009478 methionine cluster; other site 40041009479 phosphorylation site [posttranslational modification] 40041009480 metal binding site [ion binding]; metal-binding site 40041009481 HMMPfam hit to PF02255, Phosphotransferase system, lactose/cellobiose-specific IIA subunit, score 2.4e-34 40041009482 Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription]; Region: DeoR; COG2390 40041009483 Homeodomain-like domain; Region: HTH_23; pfam13384 40041009484 Putative sugar-binding domain; Region: Sugar-bind; pfam04198 40041009485 HMMPfam hit to PF04198, sugar-binding region, score 7.6e-99 40041009486 Predicted helix-turn-helix motif with score 1580.000, SD 4.57 at aa 21-42, sequence KSQTAISKEMNIYRTTVCRMLA 40041009487 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 40041009488 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 40041009489 DNA-binding site [nucleotide binding]; DNA binding site 40041009490 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 40041009491 HMMPfam hit to PF00455, Bacterial regulatory protein, DeoR, score 3.4e-35 40041009492 HMMPfam hit to PF08220, Bacterial regulatory protein, DeoR N-terminal, score 9.8e-19 40041009493 PS00894 Bacterial regulatory proteins, deoR family signature. 40041009494 glycyl-radical enzyme activating protein family; Region: PFLE_PFLC; TIGR02494 40041009495 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 40041009496 FeS/SAM binding site; other site 40041009497 PS00473 Gonadotropin-releasing hormones signature. 40041009498 PS01087 Radical activating enzymes signature. 40041009499 HMMPfam hit to PF04055, Radical SAM, score 6.8e-22 40041009500 Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788 40041009501 Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108 40041009502 GDP-binding site [chemical binding]; other site 40041009503 ACT binding site; other site 40041009504 IMP binding site; other site 40041009505 HMMPfam hit to PF00709, Adenylosuccinate synthetase, score 2.3e-303 40041009506 PS00513 Adenylosuccinate synthetase active site. 40041009507 PS01266 Adenylosuccinate synthetase GTP-binding site. 40041009508 2 probable transmembrane helices predicted for SZO18250 by TMHMM2.0 at aa 13-32 and 37-54 40041009509 Uncharacterized protein involved in tellurite resistance [Inorganic ion transport and metabolism]; Region: TelA; COG3853 40041009510 Sortases are cysteine transpeptidases, found in gram-positive bacteria, that anchor surface proteins to peptidoglycans of the bacterial cell wall envelope. They do so by catalyzing a transpeptidation reaction in which the surface protein substrate is...; Region: Sortase; cl09098 40041009511 active site 40041009512 catalytic site [active] 40041009513 1 probable transmembrane helix predicted for SZO18270 by TMHMM2.0 at aa 247-269 40041009514 HMMPfam hit to PF04203, Peptidase C60, sortase A and B, score 1.8e-29 40041009515 Sortase C (SrtC) or subfamily-3 sortases are membrane cysteine transpeptidases found in Gram-positive bacteria that anchor surface proteins to peptidoglycans of the bacterial cell wall envelope. This involves a transpeptidation reaction in which the...; Region: Sortase_C_3; cd05827 40041009516 active site 40041009517 catalytic site [active] 40041009518 2 probable transmembrane helices predicted for SZO18280 by TMHMM2.0 at aa 13-35 and 253-275 40041009519 HMMPfam hit to PF04203, Peptidase C60, sortase A and B, score 1.8e-58 40041009520 Sortase C (SrtC) or subfamily-3 sortases are membrane cysteine transpeptidases found in Gram-positive bacteria that anchor surface proteins to peptidoglycans of the bacterial cell wall envelope. This involves a transpeptidation reaction in which the...; Region: Sortase_C_3; cd05827 40041009521 active site 40041009522 catalytic site [active] 40041009523 2 probable transmembrane helices predicted for SZO18290 by TMHMM2.0 at aa 34-56 and 268-287 40041009524 HMMPfam hit to PF04203, Peptidase C60, sortase A and B, score 3.8e-63 40041009525 PS00659 Glycosyl hydrolases family 5 signature. 40041009526 Cna protein B-type domain; Region: Cna_B; pfam05738 40041009527 2 probable transmembrane helices predicted for SZO18310 by TMHMM2.0 at aa 15-37 and 260-282 40041009528 HMMPfam hit to PF05738, Collagen-binding surface protein Cna-like, B region, score 2e-16 40041009529 fimbrial isopeptide formation D2 domain; Region: RrgB_K2N_iso_D2; TIGR04226 40041009530 Repeat unit of collagen-binding protein domain B; Region: CollagenBindB; cd00222 40041009531 domain interaction interfaces [polypeptide binding]; other site 40041009532 Cna protein B-type domain; Region: Cna_B; pfam05738 40041009533 Gram positive anchor; Region: Gram_pos_anchor; pfam00746 40041009534 HMMPfam hit to PF00746, Surface protein from Gram-positive cocci, anchor region, score 1e-06 40041009535 2 probable transmembrane helices predicted for SZO18320 by TMHMM2.0 at aa 5-27 and 683-705 40041009536 HMMPfam hit to PF05738, Collagen-binding surface protein Cna-like, B region, score 6.8e-08 40041009537 Cna protein B-type domain; Region: Cna_B; pfam05738 40041009538 Cna protein B-type domain; Region: Cna_B; pfam05738 40041009539 Cna protein B-type domain; Region: Cna_B; pfam05738 40041009540 C-terminus of bacterial fibrinogen-binding adhesin; Region: SdrG_C_C; pfam10425 40041009541 Cna protein B-type domain; Region: Cna_B; pfam05738 40041009542 2 probable transmembrane helices predicted for SZO18330 by TMHMM2.0 at aa 7-29 and 1378-1400 40041009543 HMMPfam hit to PF05738, Collagen-binding surface protein Cna-like, B region, score 1.3e-06 40041009544 HMMPfam hit to PF05738, Collagen-binding surface protein Cna-like, B region, score 7.3e-09 40041009545 HMMPfam hit to PF05738, Collagen-binding surface protein Cna-like, B region, score 7.8e-19 40041009546 HMMPfam hit to PF05738, Collagen-binding surface protein Cna-like, B region, score 8.1e-11 40041009547 HMMPfam hit to PF05738, Collagen-binding surface protein Cna-like, B region, score 1e-11 40041009548 YSIRK-targeted surface antigen transcriptional regulator; Region: adjacent_YSIRK; TIGR04094 40041009549 HMMPfam hit to PF00165, Helix-turn-helix, AraC type, score 6.5e-05 40041009550 Predicted helix-turn-helix motif with score 1451.000, SD 4.13 at aa 330-351, sequence LKVSDIAKHLYISESHLRAVFK 40041009551 Hsp33-like chaperonin; Reviewed; Region: hslO; PRK00114 40041009552 Heat shock protein 33 (Hsp33): Cytosolic protein that acts as a molecular chaperone under oxidative conditions. In normal (reducing) cytosolic conditions, four conserved Cys residues are coordinated by a Zn ion. Under oxidative stress (such as heat...; Region: Hsp33; cd00498 40041009553 dimerization interface [polypeptide binding]; other site 40041009554 domain crossover interface; other site 40041009555 redox-dependent activation switch; other site 40041009556 HMMPfam hit to PF01430, Hsp33 protein, score 7.3e-152 40041009557 putative TIM-barrel protein, nifR3 family; Region: nifR3_yhdG; TIGR00737 40041009558 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 40041009559 FMN binding site [chemical binding]; other site 40041009560 active site 40041009561 catalytic residues [active] 40041009562 substrate binding site [chemical binding]; other site 40041009563 HMMPfam hit to PF01207, Dihydrouridine synthase, DuS, score 1.3e-102 40041009564 PS01136 Uncharacterized protein family UPF0034 signature. 40041009565 Deoxynucleoside kinases [Nucleotide transport and metabolism]; Region: COG1428 40041009566 Deoxyribonucleoside kinase (dNK) catalyzes the phosphorylation of deoxyribonucleosides to yield corresponding monophosphates (dNMPs). This family consists of various deoxynucleoside kinases including deoxyribo- cytidine (EC 2.7.1.74), guanosine (EC 2.7.1; Region: dNK; cd01673 40041009567 Substrate-binding site [chemical binding]; other site 40041009568 Substrate specificity [chemical binding]; other site 40041009569 PS00017 ATP/GTP-binding site motif A (P-loop). 40041009570 HMMPfam hit to PF01712, Deoxynucleoside kinase, score 1.1e-45 40041009571 ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: PhnK; COG1101 40041009572 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 40041009573 Walker A/P-loop; other site 40041009574 ATP binding site [chemical binding]; other site 40041009575 Q-loop/lid; other site 40041009576 ABC transporter signature motif; other site 40041009577 Walker B; other site 40041009578 D-loop; other site 40041009579 H-loop/switch region; other site 40041009580 HMMPfam hit to PF00005, ABC transporter related, score 3.5e-42 40041009581 PS00211 ABC transporters family signature. 40041009582 PS00017 ATP/GTP-binding site motif A (P-loop). 40041009583 Transmembrane subunit (TM) of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which are involved in the uptake of branched-chain amino acids (AAs), as well as TMs of transporters involved in the uptake of...; Region: TM_PBP1_branched-chain-AA_like; cd06574 40041009584 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 40041009585 TM-ABC transporter signature motif; other site 40041009586 7 probable transmembrane helices predicted for SZO18400 by TMHMM2.0 at aa 10-28, 41-63, 83-105, 129-151, 209-228, 235-257 and 267-282 40041009587 HMMPfam hit to PF02653, Bacterial inner-membrane translocator, score 1.5e-20 40041009588 Type I periplasmic ligand-binding domain of uncharacterized ABC-type transport systems that are predicted to be involved in the uptake of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_uncharacterized_transporter; cd06325 40041009589 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 40041009590 zinc binding site [ion binding]; other site 40041009591 putative ligand binding site [chemical binding]; other site 40041009592 HMMPfam hit to PF04392, ABC transporter substrate binding protein, score 3.5e-83 40041009593 1 probable transmembrane helix predicted for SZO18410 by TMHMM2.0 at aa 7-26 40041009594 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 40041009595 Type I periplasmic ligand-binding domain of uncharacterized ABC-type transport systems that are predicted to be involved in the uptake of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_uncharacterized_transporter; cd06325 40041009596 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 40041009597 zinc binding site [ion binding]; other site 40041009598 putative ligand binding site [chemical binding]; other site 40041009599 HMMPfam hit to PF04392, ABC transporter substrate binding protein, score 6.6e-71 40041009600 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 40041009601 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 40041009602 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 40041009603 dimer interface [polypeptide binding]; other site 40041009604 ssDNA binding site [nucleotide binding]; other site 40041009605 tetramer (dimer of dimers) interface [polypeptide binding]; other site 40041009606 HMMPfam hit to PF00436, Primosome PriB/single-strand DNA-binding, score 1.4e-23 40041009607 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 40041009608 S-adenosylmethionine binding site [chemical binding]; other site 40041009609 HMMPfam hit to PF08241, Methyltransferase type 11, score 4.6e-15 40041009610 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 40041009611 putative tRNA-binding site [nucleotide binding]; other site 40041009612 HMMPfam hit to PF01588, tRNA-binding region, score 9.3e-18 40041009613 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 40041009614 catalytic residues [active] 40041009615 HMMPfam hit to PF00085, Thioredoxin domain, score 3.7e-05 40041009616 Cellulase M and related proteins [Carbohydrate transport and metabolism]; Region: FrvX; COG1363 40041009617 glutamyl aminopeptidase; Region: glu_aminopep; TIGR03107 40041009618 PS00402 Binding-protein-dependent transport systems inner membrane comp. sign. 40041009619 HMMPfam hit to PF05343, Peptidase M42, score 3.2e-135 40041009620 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232 40041009621 pyrroline-5-carboxylate reductase; Reviewed; Region: PRK11880 40041009622 HMMPfam hit to PF03807, NADP oxidoreductase, coenzyme F420-dependent, score 1.9e-51 40041009623 PS00521 Delta 1-pyrroline-5-carboxylate reductase signature. 40041009624 4 probable transmembrane helices predicted for SZO18500 by TMHMM2.0 at aa 21-43, 47-69, 96-118 and 122-141 40041009625 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 40041009626 CAAX protease self-immunity; Region: Abi; pfam02517 40041009627 7 probable transmembrane helices predicted for SZO18510 by TMHMM2.0 at aa 17-36, 46-68, 81-103, 116-138, 151-173, 177-194 and 201-223 40041009628 HMMPfam hit to PF02517, Abortive infection protein, score 5.9e-18 40041009629 4 probable transmembrane helices predicted for SZO18520 by TMHMM2.0 at aa 21-43, 48-70, 91-113 and 123-145 40041009630 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 40041009631 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 40041009632 non-specific DNA binding site [nucleotide binding]; other site 40041009633 salt bridge; other site 40041009634 sequence-specific DNA binding site [nucleotide binding]; other site 40041009635 hypothetical protein; Validated; Region: PRK02101 40041009636 HMMPfam hit to PF03883, Protein of unknown function DUF328, score 5.3e-88 40041009637 Predicted helix-turn-helix motif with score 1162.000, SD 3.14 at aa 37-58, sequence LSLEELARAYSISIEAASKEAK 40041009638 4Fe-4S single cluster domain; Region: Fer4_12; pfam13353 40041009639 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 40041009640 FeS/SAM binding site; other site 40041009641 HMMPfam hit to PF04055, Radical SAM, score 9.3e-06 40041009642 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 40041009643 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 40041009644 Coenzyme A binding pocket [chemical binding]; other site 40041009645 HMMPfam hit to PF00583, GCN5-related N-acetyltransferase, score 3.9e-11 40041009646 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 40041009647 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 40041009648 HMMPfam hit to PF01408, Oxidoreductase, N-terminal, score 1.7e-10 40041009649 anaerobic ribonucleoside triphosphate reductase; Provisional; Region: PRK09263 40041009650 ATP cone domain; Region: ATP-cone; pfam03477 40041009651 Class III ribonucleotide reductase; Region: RNR_III; cd01675 40041009652 effector binding site; other site 40041009653 active site 40041009654 Zn binding site [ion binding]; other site 40041009655 glycine loop; other site 40041009656 HMMPfam hit to PF01228, Formate C-acetyltransferase glycine radical, score 4.1e-29 40041009657 PS00850 Glycine radical signature. 40041009658 HMMPfam hit to PF03477, ATP-cone, score 5.6e-29 40041009659 Predicted membrane protein (DUF2079); Region: DUF2079; pfam09852 40041009660 10 probable transmembrane helices predicted for SZO18590 by TMHMM2.0 at aa 36-58, 78-100, 107-129, 144-166, 178-200, 204-221, 228-250, 276-298, 311-330 and 388-410 40041009661 PS00133 Zinc carboxypeptidases, zinc-binding region 2 signature. 40041009662 hypothetical protein; Provisional; Region: PRK13678 40041009663 HMMPfam hit to PF06949, Protein of unknown function DUF1292, score 4.4e-55 40041009664 Holliday junction resolvase-like protein; Reviewed; Region: PRK00109 40041009665 HMMPfam hit to PF03652, Resolvase, holliday junction-type, YqgF-like, score 1.7e-51 40041009666 hypothetical protein; Provisional; Region: PRK05473 40041009667 HMMPfam hit to PF06135, Protein of unknown function DUF965, bacterial, score 4.8e-51 40041009668 Arsenate Reductase (ArsC) family, Spx subfamily; Spx is a unique RNA polymerase (RNAP)-binding protein present in bacilli and some mollicutes. It inhibits transcription by binding to the C-terminal domain of the alpha subunit of RNAP, disrupting complex...; Region: ArsC_Spx; cd03032 40041009669 ArsC family; Region: ArsC; pfam03960 40041009670 putative catalytic residues [active] 40041009671 thiol/disulfide switch; other site 40041009672 HMMPfam hit to PF03960, Arsenate reductase and related, score 8.5e-56 40041009673 recombinase A; Provisional; Region: recA; PRK09354 40041009674 RecA is a bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response. RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983 40041009675 hexamer interface [polypeptide binding]; other site 40041009676 Walker A motif; other site 40041009677 ATP binding site [chemical binding]; other site 40041009678 Walker B motif; other site 40041009679 HMMPfam hit to PF00154, RecA, score 8.7e-243 40041009680 PS00321 recA signature. 40041009681 PS00017 ATP/GTP-binding site motif A (P-loop). 40041009682 competence damage-inducible protein A; Provisional; Region: PRK00549 40041009683 Competence-damaged protein. CinA is the first gene in the competence- inducible (cin) operon and is thought to be specifically required at some stage in the process of transformation. This domain is closely related to a domain, found in a variety of...; Region: cinA; cd00885 40041009684 putative MPT binding site; other site 40041009685 Uncharacterized protein (competence- and mitomycin-induced) [General function prediction only]; Region: CinA; COG1546 40041009686 HMMPfam hit to PF02464, CinA, C-terminal, score 3.1e-64 40041009687 HMMPfam hit to PF00994, Molybdopterin binding, score 7e-48 40041009688 3 probable transmembrane helices predicted for SZO18660 by TMHMM2.0 at aa 7-29, 39-61 and 68-90 40041009689 PLA2_like: Phospholipase A2, a super-family of secretory and cytosolic enzymes; the latter are either Ca dependent or Ca independent. PLA2 cleaves the sn-2 position of the glycerol backbone of phospholipids (PC or phosphatidylethanolamine), usually in a...; Region: PLA2_like; cl05417 40041009690 primary metal binding site; other site 40041009691 catalytic residues [active] 40041009692 1 probable transmembrane helix predicted for SZO18670 by TMHMM2.0 at aa 7-26 40041009693 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 40041009694 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 40041009695 non-specific DNA binding site [nucleotide binding]; other site 40041009696 salt bridge; other site 40041009697 sequence-specific DNA binding site [nucleotide binding]; other site 40041009698 HMMPfam hit to PF01381, Helix-turn-helix type 3, score 2.9e-07 40041009699 Methyladenine glycosylase; Region: Adenine_glyco; pfam03352 40041009700 HMMPfam hit to PF03352, Methyladenine glycosylase, score 1.3e-87 40041009701 Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116 40041009702 RuvA N terminal domain; Region: RuvA_N; pfam01330 40041009703 RuvA, C-terminal domain; Region: RuvA_C; pfam07499 40041009704 HMMPfam hit to PF07499, DNA helicase, Holliday junction RuvA type, C-terminal domain III, score 6e-10 40041009705 HMMPfam hit to PF01330, DNA helicase, Holliday junction RuvA type, domain I, bacterial, score 1e-25 40041009706 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 40041009707 Major Facilitator Superfamily; Region: MFS_1; pfam07690 40041009708 putative substrate translocation pore; other site 40041009709 12 probable transmembrane helices predicted for SZO18710 by TMHMM2.0 at aa 16-35, 40-62, 75-93, 98-120, 141-160, 165-187, 218-236, 256-278, 291-310, 314-336, 349-371 and 381-400 40041009710 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 40041009711 HMMPfam hit to PF07690, Major facilitator superfamily MFS-1, score 6.8e-31 40041009712 PS00216 Sugar transport proteins signature 1. 40041009713 DNA mismatch repair protein; Reviewed; Region: mutL; PRK00095 40041009714 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 40041009715 ATP binding site [chemical binding]; other site 40041009716 Mg2+ binding site [ion binding]; other site 40041009717 G-X-G motif; other site 40041009718 MutL_Trans: transducer domain, having a ribosomal S5 domain 2-like fold, conserved in the C-terminal domain of DNA mismatch repair (MutL/MLH1/PMS2) family. This transducer domain is homologous to the second domain of the DNA gyrase B subunit, which is...; Region: MutL_Trans; cd00782 40041009719 ATP binding site [chemical binding]; other site 40041009720 MutL C terminal dimerisation domain; Region: MutL_C; pfam08676 40041009721 HMMPfam hit to PF08676, MutL, C-terminal, dimerisation, score 1.9e-52 40041009722 HMMPfam hit to PF01119, DNA mismatch repair protein, C-terminal, score 1e-40 40041009723 PS00058 DNA mismatch repair proteins mutL / hexB / PMS1 signature. 40041009724 HMMPfam hit to PF02518, ATP-binding region, ATPase-like, score 6.7e-09 40041009725 DNA mismatch repair protein MutS; Provisional; Region: PRK05399 40041009726 MutS domain I; Region: MutS_I; pfam01624 40041009727 MutS domain II; Region: MutS_II; pfam05188 40041009728 MutS domain III; Region: MutS_III; pfam05192 40041009729 MutS domain V; Region: MutS_V; pfam00488 40041009730 Walker A/P-loop; other site 40041009731 ATP binding site [chemical binding]; other site 40041009732 Q-loop/lid; other site 40041009733 ABC transporter signature motif; other site 40041009734 Walker B; other site 40041009735 D-loop; other site 40041009736 H-loop/switch region; other site 40041009737 HMMPfam hit to PF00488, DNA mismatch repair protein MutS, C-terminal, score 3.1e-151 40041009738 PS00486 DNA mismatch repair proteins mutS family signature. 40041009739 PS00017 ATP/GTP-binding site motif A (P-loop). 40041009740 HMMPfam hit to PF05192, MutS III, score 2e-93 40041009741 HMMPfam hit to PF05190, MutS IV, score 2.3e-37 40041009742 HMMPfam hit to PF05188, MutS II, score 4.8e-31 40041009743 HMMPfam hit to PF01624, DNA mismatch repair protein MutS, N-terminal, score 6.9e-70 40041009744 Protein of unknown function (DUF964); Region: DUF964; cl01483 40041009745 Arginine repressor, DNA binding domain; Region: Arg_repressor; pfam01316 40041009746 arginine repressor; Region: argR_whole; TIGR01529 40041009747 Arginine repressor, C-terminal domain; Region: Arg_repressor_C; pfam02863 40041009748 HMMPfam hit to PF02863, Arginine repressor, score 3.9e-25 40041009749 HMMPfam hit to PF01316, Arginine repressor, score 1.1e-24 40041009750 arginyl-tRNA synthetase; Reviewed; Region: PRK12451 40041009751 Arginyl tRNA synthetase N terminal dom; Region: Arg_tRNA_synt_N; smart01016 40041009752 catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671 40041009753 active site 40041009754 HIGH motif; other site 40041009755 KMSK motif region; other site 40041009756 Anticodon-binding domain of arginyl tRNA synthetases; Region: Anticodon_Ia_Arg; cd07956 40041009757 tRNA binding surface [nucleotide binding]; other site 40041009758 anticodon binding site; other site 40041009759 HMMPfam hit to PF03485, Arginyl tRNA synthetase, class Ic, N-terminal, score 3.1e-29 40041009760 HMMPfam hit to PF00750, Arginyl-tRNA synthetase, class Ic, core, score 8.1e-102 40041009761 HMMPfam hit to PF05746, DALR anticodon binding, score 3.6e-50 40041009762 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 40041009763 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 40041009764 ABC transporter; Region: ABC_tran_2; pfam12848 40041009765 ABC-type molybdenum transport system, ATPase component/photorepair protein PhrA [Inorganic ion transport and metabolism]; Region: ModF; COG1119 40041009766 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 40041009767 HMMPfam hit to PF00005, ABC transporter related, score 5.6e-24 40041009768 PS00211 ABC transporters family signature. 40041009769 PS00017 ATP/GTP-binding site motif A (P-loop). 40041009770 HMMPfam hit to PF00005, ABC transporter related, score 2.2e-20 40041009771 PS00017 ATP/GTP-binding site motif A (P-loop). 40041009772 Uncharacterized conserved protein [Function unknown]; Region: COG1284 40041009773 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 40041009774 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 40041009775 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 40041009776 6 probable transmembrane helices predicted for SZO18780 by TMHMM2.0 at aa 13-30, 40-62, 74-96, 111-133, 153-172 and 177-199 40041009777 HMMPfam hit to PF02588, Protein of unknown function DUF161, score 1.3e-22 40041009778 HMMPfam hit to PF02588, Protein of unknown function DUF161, score 5e-25 40041009779 Uncharacterized conserved protein [Function unknown]; Region: COG1284 40041009780 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 40041009781 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 40041009782 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 40041009783 HMMPfam hit to PF02588, Protein of unknown function DUF161, score 8.4e-18 40041009784 5 probable transmembrane helices predicted for SZO18790 by TMHMM2.0 at aa 12-34, 49-71, 78-95, 110-132 and 156-178 40041009785 HMMPfam hit to PF02588, Protein of unknown function DUF161, score 6.5e-20 40041009786 Uncharacterized conserved protein [Function unknown]; Region: COG1284 40041009787 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 40041009788 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 40041009789 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 40041009790 HMMPfam hit to PF02588, Protein of unknown function DUF161, score 3.6e-26 40041009791 5 probable transmembrane helices predicted for SZO18800 by TMHMM2.0 at aa 41-63, 83-105, 112-130, 140-162 and 183-205 40041009792 HMMPfam hit to PF02588, Protein of unknown function DUF161, score 2.9e-24 40041009793 aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476 40041009794 EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317 40041009795 dimer interface [polypeptide binding]; other site 40041009796 anticodon binding site; other site 40041009797 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777 40041009798 homodimer interface [polypeptide binding]; other site 40041009799 motif 1; other site 40041009800 active site 40041009801 motif 2; other site 40041009802 GAD domain; Region: GAD; pfam02938 40041009803 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777 40041009804 motif 3; other site 40041009805 HMMPfam hit to PF00152, Aminoacyl-tRNA synthetase, class II (D, K and N), score 9.7e-215 40041009806 PS00339 Aminoacyl-transfer RNA synthetases class-II signature 2. 40041009807 HMMPfam hit to PF02938, GAD, score 3e-36 40041009808 PS00179 Aminoacyl-transfer RNA synthetases class-II signature 1. 40041009809 HMMPfam hit to PF01336, Nucleic acid binding, OB-fold, tRNA/helicase-type, score 4.9e-23 40041009810 Probable gene remnant 40041009811 histidyl-tRNA synthetase; Reviewed; Region: hisS; PRK00037 40041009812 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 40041009813 dimer interface [polypeptide binding]; other site 40041009814 motif 1; other site 40041009815 active site 40041009816 motif 2; other site 40041009817 HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859 40041009818 anticodon binding site; other site 40041009819 HMMPfam hit to PF03129, Anticodon-binding, score 1.4e-17 40041009820 PS00339 Aminoacyl-transfer RNA synthetases class-II signature 2. 40041009821 HMMPfam hit to PF00587, Aminoacyl-tRNA synthetase, class II (G, H, P and S), score 2.4e-57 40041009822 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 40041009823 50S ribosomal protein L32; Validated; Region: rpmF; PRK01110 40041009824 HMMPfam hit to PF01783, Ribosomal protein L32p, score 3.8e-22 40041009825 50S ribosomal protein L33; Validated; Region: rpmG; PRK00595 40041009826 HMMPfam hit to PF00471, Ribosomal protein L33, score 1e-17 40041009827 Protein of unknown function (DUF4065); Region: DUF4065; pfam13274 40041009828 Region found in RelA / SpoT proteins; Region: RelA_SpoT; smart00954 40041009829 metal binding triad [ion binding]; metal-binding site 40041009830 Gram positive anchor; Region: Gram_pos_anchor; pfam00746 40041009831 HMMPfam hit to PF00746, Surface protein from Gram-positive cocci, anchor region, score 3.3e-07 40041009832 PS00343 Gram-positive cocci surface proteins 'anchoring' hexapeptide. 40041009833 1 probable transmembrane helix predicted for SZO18890 by TMHMM2.0 at aa 597-619 40041009834 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 40041009835 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 40041009836 9 probable transmembrane helices predicted for SZO18910 by TMHMM2.0 at aa 21-43, 124-143, 155-177, 181-203, 216-238, 243-265, 278-297, 301-323 and 335-357 40041009837 PS00038 Myc-type, 'helix-loop-helix' dimerization domain signature. 40041009838 HMMPfam hit to PF02518, ATP-binding region, ATPase-like, score 6.7e-05 40041009839 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 40041009840 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 40041009841 active site 40041009842 phosphorylation site [posttranslational modification] 40041009843 intermolecular recognition site; other site 40041009844 dimerization interface [polypeptide binding]; other site 40041009845 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 40041009846 DNA binding residues [nucleotide binding] 40041009847 dimerization interface [polypeptide binding]; other site 40041009848 HMMPfam hit to PF00072, Response regulator receiver, score 2e-22 40041009849 HMMPfam hit to PF00196, Bacterial regulatory protein, LuxR, score 3.1e-15 40041009850 Predicted helix-turn-helix motif with score 1093.000, SD 2.91 at aa 154-175, sequence YSNEKISKKLYISRRTVDTHVS 40041009851 Pseudomonas avirulence D protein (AvrD); Region: AvrD; pfam05655 40041009852 HMMPfam hit to PF05655, Pseudomonas avirulence D, score 1.4e-09 40041009853 PS00017 ATP/GTP-binding site motif A (P-loop). 40041009854 PS00017 ATP/GTP-binding site motif A (P-loop). 40041009855 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 40041009856 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 40041009857 Walker A/P-loop; other site 40041009858 ATP binding site [chemical binding]; other site 40041009859 Q-loop/lid; other site 40041009860 ABC transporter signature motif; other site 40041009861 Walker B; other site 40041009862 D-loop; other site 40041009863 H-loop/switch region; other site 40041009864 HMMPfam hit to PF00005, ABC transporter related, score 4.7e-61 40041009865 PS00017 ATP/GTP-binding site motif A (P-loop). 40041009866 PS00211 ABC transporters family signature. 40041009867 ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]; Region: LolE; COG4591 40041009868 FtsX-like permease family; Region: FtsX; pfam02687 40041009869 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 40041009870 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 40041009871 FtsX-like permease family; Region: FtsX; pfam02687 40041009872 8 probable transmembrane helices predicted for SZO18960 by TMHMM2.0 at aa 19-41, 260-282, 302-324, 347-369, 424-446, 628-650, 677-699 and 719-741 40041009873 HMMPfam hit to PF02687, Protein of unknown function DUF214, permase predicted, score 1.7e-20 40041009874 HMMPfam hit to PF02687, Protein of unknown function DUF214, permase predicted, score 6.8e-16 40041009875 Probable gene remnant. CDS lacks an N-terminal signal sequence required for the processing of this protein 40041009876 HMMPfam hit to PF00746, Surface protein from Gram-positive cocci, anchor region, score 8.2e-08 40041009877 1 probable transmembrane helix predicted for SZO18970 by TMHMM2.0 at aa 288-310 40041009878 Predicted membrane protein [Function unknown]; Region: COG2035 40041009879 HMMPfam hit to PF04018, Protein of unknown function DUF368, score 3e-107 40041009880 8 probable transmembrane helices predicted for SZO18980 by TMHMM2.0 at aa 13-35, 48-70, 80-102, 115-137, 152-174, 186-204, 219-236 and 249-271 40041009881 Coenzyme A pyrophosphatase (CoAse), a member of the Nudix hydrolase superfamily, functions to catalyze the elimination of oxidized inactive CoA, which can inhibit CoA-utilizing enzymes. The need of CoAses mainly arises under conditions of oxidative...; Region: CoAse; cd03426 40041009882 putative active site [active] 40041009883 putative CoA binding site [chemical binding]; other site 40041009884 nudix motif; other site 40041009885 metal binding site [ion binding]; metal-binding site 40041009886 HMMPfam hit to PF00293, NUDIX hydrolase, core, score 4.4e-17 40041009887 PS00893 mutT domain signature. 40041009888 Predicted transcriptional regulators [Transcription]; Region: COG1695 40041009889 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 40041009890 HMMPfam hit to PF03551, Transcriptional regulator PadR-like, score 1.8e-20 40041009891 Predicted membrane protein [Function unknown]; Region: COG4709 40041009892 HMMPfam hit to PF08006, Protein of unknown function DUF1700, score 0.00043 40041009893 Predicted membrane protein [Function unknown]; Region: COG4709 40041009894 Domain of unknown function (DUF4097); Region: DUF4097; pfam13349 40041009895 Domain of unknown function (DUF4098); Region: DUF4098; pfam13345 40041009896 HMMPfam hit to PF08006, Protein of unknown function DUF1700, score 9.6e-09 40041009897 Predicted membrane protein [Function unknown]; Region: COG1511 40041009898 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061 40041009899 YhgE/Pip C-terminal domain; Region: pip_yhgE_Cterm; TIGR03062 40041009900 6 probable transmembrane helices predicted for SZO19030 by TMHMM2.0 at aa 13-35, 576-598, 618-640, 650-669, 674-696 and 729-751 40041009901 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 40041009902 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 40041009903 HMMPfam hit to PF00440, Transcriptional regulator, TetR-like, DNA-binding, bacterial/archaeal, score 5.2e-07 40041009904 Predicted helix-turn-helix motif with score 1376.000, SD 3.87 at aa 28-49, sequence VTTVQLAKMAGISRSSFYTHYK 40041009905 genomic island 40041009906 Plasmid stabilisation system protein; Region: Plasmid_stabil; pfam05016 40041009907 HMMPfam hit to PF05016, Plasmid stabilization system, score 6.7e-05 40041009908 RelB antitoxin; Region: RelB; cl01171 40041009909 CDS contains frameshifts after codon 63 40041009910 Probable gene remnant. CDS lacks appropriate translational start site 40041009911 30S ribosomal protein S4; Validated; Region: rpsD; PRK05327 40041009912 Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163 40041009913 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 40041009914 RNA binding surface [nucleotide binding]; other site 40041009915 HMMPfam hit to PF01479, RNA-binding S4, score 1.5e-23 40041009916 PS00632 Ribosomal protein S4 signature. 40041009917 HMMPfam hit to PF00163, Ribosomal protein S4, score 6e-26 40041009918 Uncharacterized protein conserved in bacteria [Function unknown]; Region: Veg; COG4466 40041009919 HMMPfam hit to PF06257, Protein of unknown function DUF1021, score 1.3e-40 40041009920 replicative DNA helicase; Provisional; Region: PRK05748 40041009921 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 40041009922 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 40041009923 Walker A motif; other site 40041009924 ATP binding site [chemical binding]; other site 40041009925 Walker B motif; other site 40041009926 DNA binding loops [nucleotide binding] 40041009927 HMMPfam hit to PF03796, DNA helicase, DnaB-like, C-terminal, score 2e-136 40041009928 PS00017 ATP/GTP-binding site motif A (P-loop). 40041009929 HMMPfam hit to PF00772, DNA helicase, DnaB-like, N-terminal, score 1.5e-46 40041009930 50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137 40041009931 Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281 40041009932 Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948 40041009933 HMMPfam hit to PF03948, Ribosomal protein L9, score 3.3e-17 40041009934 HMMPfam hit to PF01281, Ribosomal protein L9, score 1.9e-17 40041009935 PS00651 Ribosomal protein L9 signature. 40041009936 Predicted signaling protein consisting of a modified GGDEF domain and a DHH domain [Signal transduction mechanisms]; Region: COG3887 40041009937 DHH family; Region: DHH; pfam01368 40041009938 DHHA1 domain; Region: DHHA1; pfam02272 40041009939 HMMPfam hit to PF02272, Phosphoesterase, DHHA1, score 1.3e-13 40041009940 HMMPfam hit to PF01368, Phosphoesterase, RecJ-like, score 1.7e-43 40041009941 2 probable transmembrane helices predicted for SZO19110 by TMHMM2.0 at aa 4-26 and 33-52 40041009942 tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA; Validated; Region: PRK05192 40041009943 NAD(FAD)-utilizing enzyme possibly involved in translation [Translation, ribosomal structure and biogenesis]; Region: Gid; COG1206 40041009944 GidA associated domain 3; Region: GIDA_assoc_3; pfam13932 40041009945 HMMPfam hit to PF01134, Glucose-inhibited division protein A, score 2.4e-263 40041009946 PS01281 Glucose inhibited division protein A family signature 2. 40041009947 PS01280 Glucose inhibited division protein A family signature 1. 40041009948 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 40041009949 nudix motif; other site 40041009950 HMMPfam hit to PF00293, NUDIX hydrolase, core, score 1.6e-11 40041009951 PS00893 mutT domain signature. 40041009952 Predicted tRNA(5-methylaminomethyl-2-thiouridylate) methyltransferase, contains the PP-loop ATPase domain [Translation, ribosomal structure and biogenesis]; Region: TrmU; COG0482 40041009953 tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998 40041009954 HMMPfam hit to PF03054, tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase, score 7.2e-222 40041009955 L-serine dehydratase, iron-sulfur-dependent, beta subunit; Region: sda_beta; TIGR00719 40041009956 Serine dehydratase beta chain; Region: SDH_beta; pfam03315 40041009957 C-terminal ACT domain of the L-serine dehydratase (LSD), iron-sulfur-dependent, beta subunit; Region: ACT_LSD; cd04903 40041009958 putative L-serine binding site [chemical binding]; other site 40041009959 HMMPfam hit to PF03315, Serine dehydratase beta chain, score 7.5e-48 40041009960 PS00591 Glycosyl hydrolases family 10 active site. 40041009961 HMMPfam hit to PF01842, Amino acid-binding ACT, score 1.2e-08 40041009962 Serine dehydratase alpha chain; Region: SDH_alpha; cl12120 40041009963 L-serine deaminase [Amino acid transport and metabolism]; Region: SdaA; COG1760 40041009964 HMMPfam hit to PF03313, Serine dehydratase alpha chain, score 6e-108 40041009965 PS00867 Carbamoyl-phosphate synthase subdomain signature 2. 40041009966 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 40041009967 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 40041009968 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 40041009969 motif II; other site 40041009970 HMMPfam hit to PF00702, Haloacid dehalogenase-like hydrolase, score 1.6e-16 40041009971 PS00225 Crystallins beta and gamma 'Greek key' motif signature. 40041009972 HMMPfam hit to PF06737, Transglycosylase-like, score 1.2e-19 40041009973 1 probable transmembrane helix predicted for SZO19180 by TMHMM2.0 at aa 12-31 40041009974 ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619 40041009975 4 probable transmembrane helices predicted for SZO19190 by TMHMM2.0 at aa 25-57, 72-94, 106-128 and 245-262 40041009976 HMMPfam hit to PF02361, Cobalt transport protein, score 8.3e-64 40041009977 cobalt transporter ATP-binding subunit; Provisional; Region: cbiO; PRK13649 40041009978 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 40041009979 Walker A/P-loop; other site 40041009980 ATP binding site [chemical binding]; other site 40041009981 Q-loop/lid; other site 40041009982 ABC transporter signature motif; other site 40041009983 Walker B; other site 40041009984 D-loop; other site 40041009985 H-loop/switch region; other site 40041009986 HMMPfam hit to PF00005, ABC transporter related, score 4.6e-55 40041009987 PS00211 ABC transporters family signature. 40041009988 PS00017 ATP/GTP-binding site motif A (P-loop). 40041009989 cobalt transporter ATP-binding subunit; Provisional; Region: cbiO; PRK13650 40041009990 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 40041009991 Walker A/P-loop; other site 40041009992 ATP binding site [chemical binding]; other site 40041009993 Q-loop/lid; other site 40041009994 ABC transporter signature motif; other site 40041009995 Walker B; other site 40041009996 D-loop; other site 40041009997 H-loop/switch region; other site 40041009998 HMMPfam hit to PF00005, ABC transporter related, score 5.2e-58 40041009999 PS00211 ABC transporters family signature. 40041010000 PS00017 ATP/GTP-binding site motif A (P-loop). 40041010001 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453 40041010002 HMMPfam hit to PF01066, CDP-alcohol phosphatidyltransferase, score 1.8e-30 40041010003 3 probable transmembrane helices predicted for SZO19220 by TMHMM2.0 at aa 21-43, 78-100 and 140-162 40041010004 PS00379 CDP-alcohol phosphatidyltransferases signature. 40041010005 Predicted transcriptional regulator contains Xre-like HTH domain [Function unknown]; Region: COG1426 40041010006 Helix-turn-helix domain; Region: HTH_25; pfam13413 40041010007 1 probable transmembrane helix predicted for SZO19230 by TMHMM2.0 at aa 172-194 40041010008 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 40041010009 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 40041010010 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 40041010011 HMMPfam hit to PF05193, Peptidase M16, C-terminal, score 9.7e-16 40041010012 HMMPfam hit to PF00675, Peptidase M16, N-terminal, score 5.4e-15 40041010013 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 40041010014 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 40041010015 HMMPfam hit to PF05193, Peptidase M16, C-terminal, score 3.3e-28 40041010016 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 40041010017 RNA binding surface [nucleotide binding]; other site 40041010018 HMMPfam hit to PF01479, RNA-binding S4, score 0.022 40041010019 recombination protein F; Reviewed; Region: recF; PRK00064 40041010020 ATP-binding cassette domain of RecF; Region: ABC_RecF; cd03242 40041010021 Walker A/P-loop; other site 40041010022 ATP binding site [chemical binding]; other site 40041010023 Q-loop/lid; other site 40041010024 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 40041010025 ABC transporter signature motif; other site 40041010026 Walker B; other site 40041010027 D-loop; other site 40041010028 H-loop/switch region; other site 40041010029 HMMPfam hit to PF02463, SMC protein, N-terminal, score 3.6e-09 40041010030 PS00017 ATP/GTP-binding site motif A (P-loop). 40041010031 PS00617 RecF protein signature 1. 40041010032 PS00618 RecF protein signature 2. 40041010033 Putative glucose uptake permease [Carbohydrate transport and metabolism]; Region: GlcU; COG4975 40041010034 9 probable transmembrane helices predicted for SZO19280 by TMHMM2.0 at aa 5-22, 32-51, 58-80, 114-133, 153-175, 179-200, 207-229, 234-256 and 268-285 40041010035 HMMPfam hit to PF06800, Sugar transport, score 3.1e-153 40041010036 Protein of unknown function (DUF2974); Region: DUF2974; pfam11187 40041010037 Protein of unknown function (DUF1310); Region: DUF1310; pfam07006 40041010038 HMMPfam hit to PF07006, Protein of unknown function DUF1310, score 6.9e-21 40041010039 1 probable transmembrane helix predicted for SZO19300 by TMHMM2.0 at aa 4-21 40041010040 Protein of unknown function (DUF1310); Region: DUF1310; pfam07006 40041010041 HMMPfam hit to PF07006, Protein of unknown function DUF1310, score 1.3e-21 40041010042 1 probable transmembrane helix predicted for SZO19310 by TMHMM2.0 at aa 4-23 40041010043 Protein of unknown function (DUF1310); Region: DUF1310; pfam07006 40041010044 HMMPfam hit to PF07006, Protein of unknown function DUF1310, score 1.2e-23 40041010045 1 probable transmembrane helix predicted for SZO19320 by TMHMM2.0 at aa 7-21 40041010046 Protein of unknown function (DUF1310); Region: DUF1310; pfam07006 40041010047 HMMPfam hit to PF07006, Protein of unknown function DUF1310, score 1.3e-17 40041010048 1 probable transmembrane helix predicted for SZO19330 by TMHMM2.0 at aa 4-23 40041010049 inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567 40041010050 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 40041010051 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein. IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a...; Region: CBS_pair_IMPDH; cd04601 40041010052 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 40041010053 active site 40041010054 HMMPfam hit to PF00478, IMP dehydrogenase/GMP reductase, score 2.7e-241 40041010055 PS00487 IMP dehydrogenase / GMP reductase signature. 40041010056 HMMPfam hit to PF00571, Cystathionine beta-synthase, core, score 1.8e-28 40041010057 tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282 40041010058 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 40041010059 active site 40041010060 HIGH motif; other site 40041010061 dimer interface [polypeptide binding]; other site 40041010062 KMSKS motif; other site 40041010063 HMMPfam hit to PF00579, Aminoacyl-tRNA synthetase, class Ib, score 1.1e-82 40041010064 PS00178 Aminoacyl-transfer RNA synthetases class-I signature. 40041010065 Uncharacterized conserved protein [Function unknown]; Region: COG1284 40041010066 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 40041010067 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 40041010068 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 40041010069 5 probable transmembrane helices predicted for SZO19360 by TMHMM2.0 at aa 5-27, 47-69, 103-122, 142-164 and 171-190 40041010070 HMMPfam hit to PF02588, Protein of unknown function DUF161, score 1e-22 40041010071 HMMPfam hit to PF02588, Protein of unknown function DUF161, score 5.9e-21 40041010072 ABC transporter ATP-binding protein; Provisional; Region: PRK15064 40041010073 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 40041010074 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 40041010075 ABC transporter; Region: ABC_tran_2; pfam12848 40041010076 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 40041010077 HMMPfam hit to PF00005, ABC transporter related, score 3.4e-44 40041010078 PS00017 ATP/GTP-binding site motif A (P-loop). 40041010079 HMMPfam hit to PF00005, ABC transporter related, score 7.6e-23 40041010080 PS00211 ABC transporters family signature. 40041010081 Predicted membrane protein [Function unknown]; Region: COG4485 40041010082 14 probable transmembrane helices predicted for SZO19380 by TMHMM2.0 at aa 7-29, 77-99, 106-125, 135-152, 159-178, 193-215, 228-250, 290-312, 319-336, 351-373, 378-400, 405-427, 434-456 and 831-853 40041010083 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 40041010084 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 40041010085 rRNA large subunit methyltransferase; Provisional; Region: PRK00103 40041010086 HMMPfam hit to PF02590, Protein of unknown function DUF163, score 6.9e-129 40041010087 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 40041010088 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 40041010089 protein binding site [polypeptide binding]; other site 40041010090 1 probable transmembrane helix predicted for SZO19400 by TMHMM2.0 at aa 10-32 40041010091 HMMPfam hit to PF00089, Peptidase S1 and S6, chymotrypsin/Hap, score 1e-21 40041010092 Stage 0 sporulation protein J (antagonist of Soj) containing ParB-like nuclease domain [Transcription]; Region: Spo0J; COG1475 40041010093 ParB-like nuclease domain; Region: ParBc; pfam02195 40041010094 KorB domain; Region: KorB; pfam08535 40041010095 HMMPfam hit to PF02195, ParB-like nuclease, score 1.9e-36 40041010096 Predicted helix-turn-helix motif with score 1642.000, SD 4.78 at aa 119-140, sequence MTHEDIATYMGKSRPYISNTIR