-- dump date 20140620_082032 -- class Genbank::misc_feature -- table misc_feature_note -- id note 981539000001 chromosomal replication initiation protein; Reviewed; Region: dnaA; PRK00149 981539000002 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 981539000003 Walker A motif; other site 981539000004 ATP binding site [chemical binding]; other site 981539000005 Walker B motif; other site 981539000006 arginine finger; other site 981539000007 C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571 981539000008 DnaA box-binding interface [nucleotide binding]; other site 981539000009 DNA polymerase III subunit beta; Validated; Region: PRK05643 981539000010 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140 981539000011 putative DNA binding surface [nucleotide binding]; other site 981539000012 dimer interface [polypeptide binding]; other site 981539000013 beta-clamp/clamp loader binding surface; other site 981539000014 beta-clamp/translesion DNA polymerase binding surface; other site 981539000015 Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase [Lipid metabolism / General function prediction only]; Region: LCB5; COG1597 981539000016 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 981539000017 Bacterial protein of unknown function (DUF951); Region: DUF951; pfam06107 981539000018 GTP-binding protein YchF; Reviewed; Region: PRK09601 981539000019 YchF GTPase; Region: YchF; cd01900 981539000020 G1 box; other site 981539000021 GTP/Mg2+ binding site [chemical binding]; other site 981539000022 Switch I region; other site 981539000023 G2 box; other site 981539000024 Switch II region; other site 981539000025 G3 box; other site 981539000026 G4 box; other site 981539000027 G5 box; other site 981539000028 TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867 981539000029 Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462 981539000030 putative active site [active] 981539000031 catalytic residue [active] 981539000032 Transcription-repair coupling factor (superfamily II helicase) [DNA replication, recombination, and repair / Transcription]; Region: Mfd; COG1197 981539000033 CarD-like/TRCF domain; Region: CarD_TRCF; smart01058 981539000034 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 981539000035 ATP binding site [chemical binding]; other site 981539000036 putative Mg++ binding site [ion binding]; other site 981539000037 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 981539000038 nucleotide binding region [chemical binding]; other site 981539000039 ATP-binding site [chemical binding]; other site 981539000040 This domain is found in proteins necessary for strand-specific repair in DNA such as TRCF in Escherichia coli; Region: TRCF; smart00982 981539000041 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 981539000042 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 981539000043 sequence-specific DNA binding site [nucleotide binding]; other site 981539000044 salt bridge; other site 981539000045 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 981539000046 RNA binding surface [nucleotide binding]; other site 981539000047 Septum formation initiator [Cell division and chromosome partitioning]; Region: COG2919 981539000048 Septum formation initiator; Region: DivIC; pfam04977 981539000049 Beta-lactamase class A [Defense mechanisms]; Region: PenP; COG2367 981539000050 Beta-lactamase enzyme family; Region: Beta-lactamase2; pfam13354 981539000051 tRNA(Ile)-lysidine synthase MesJ [Cell cycle control, cell division, chromosome partitioning]; Region: MesJ; COG0037 981539000052 N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992 981539000053 Ligand Binding Site [chemical binding]; other site 981539000054 TilS substrate C-terminal domain; Region: TilS_C; smart00977 981539000055 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 981539000056 active site 981539000057 ATP-dependent Zn proteases [Posttranslational modification, protein turnover, chaperones]; Region: HflB; COG0465 981539000058 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 981539000059 Walker A motif; other site 981539000060 ATP binding site [chemical binding]; other site 981539000061 Walker B motif; other site 981539000062 arginine finger; other site 981539000063 Peptidase family M41; Region: Peptidase_M41; pfam01434 981539000064 rod shape-determining protein MreC; Provisional; Region: PRK13922 981539000065 rod shape-determining protein MreC; Region: MreC; pfam04085 981539000066 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3883 981539000067 CHAP domain; Region: CHAP; pfam05257 981539000068 Surface antigen [General function prediction only]; Region: COG3942 981539000069 ribose-phosphate pyrophosphokinase; Provisional; Region: PRK02269 981539000070 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 981539000071 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 981539000072 active site 981539000073 aromatic amino acid aminotransferase; Validated; Region: PRK07309 981539000074 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 981539000075 pyridoxal 5'-phosphate binding site [chemical binding]; other site 981539000076 homodimer interface [polypeptide binding]; other site 981539000077 catalytic residue [active] 981539000078 Recombination protein O N terminal; Region: RecO_N; pfam11967 981539000079 DNA repair protein RecO; Region: reco; TIGR00613 981539000080 Recombination protein O C terminal; Region: RecO_C; pfam02565 981539000081 putative phosphate acyltransferase; Provisional; Region: PRK05331 981539000082 acyl carrier protein; Provisional; Region: PRK12449 981539000083 phosphoribosylaminoimidazole-succinocarboxamide synthase; Reviewed; Region: PRK09362 981539000084 bacterial and archaeal 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_PurC; cd01415 981539000085 ATP binding site [chemical binding]; other site 981539000086 active site 981539000087 substrate binding site [chemical binding]; other site 981539000088 phosphoribosylformylglycinamidine synthase, clade II; Region: FGAM-synthase; TIGR01857 981539000089 AIR (aminoimidazole ribonucleotide) synthase related protein. This family includes Hydrogen expression/formation protein HypE, AIR synthases, FGAM (formylglycinamidine ribonucleotide) synthase and Selenophosphate synthetase (SelD). The N-terminal domain...; Region: PurM-like; cl10019 981539000090 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203 981539000091 dimerization interface [polypeptide binding]; other site 981539000092 ATP binding site [chemical binding]; other site 981539000093 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat2; cd02204 981539000094 dimerization interface [polypeptide binding]; other site 981539000095 ATP binding site [chemical binding]; other site 981539000096 Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740 981539000097 putative active site [active] 981539000098 catalytic triad [active] 981539000099 amidophosphoribosyltransferase; Provisional; Region: PRK07272 981539000100 Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715 981539000101 active site 981539000102 tetramer interface [polypeptide binding]; other site 981539000103 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 981539000104 active site 981539000105 phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385 981539000106 PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196 981539000107 dimerization interface [polypeptide binding]; other site 981539000108 putative ATP binding site [chemical binding]; other site 981539000109 phosphoribosylglycinamide formyltransferase; Reviewed; Region: purN; PRK05647 981539000110 Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645 981539000111 active site 981539000112 substrate binding site [chemical binding]; other site 981539000113 cosubstrate binding site; other site 981539000114 catalytic site [active] 981539000115 GNAT acetyltransferase; Region: GNAT_acetyltran; pfam12746 981539000116 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881 981539000117 Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal ATIC formylase domain that formylates...; Region: IMPCH; cd01421 981539000118 purine monophosphate binding site [chemical binding]; other site 981539000119 dimer interface [polypeptide binding]; other site 981539000120 putative catalytic residues [active] 981539000121 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; smart00798 981539000122 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; cl03362 981539000123 phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885 981539000124 Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844 981539000125 Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Region: GARS_A; pfam01071 981539000126 Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843 981539000127 Protein of unknown function (DUF523); Region: DUF523; pfam04463 981539000128 Phosphoribosylcarboxyaminoimidazole (NCAIR) mutase [Nucleotide transport and metabolism]; Region: PurE; COG0041 981539000129 phosphoribosylaminoimidazole carboxylase ATPase subunit; Reviewed; Region: PRK06019 981539000130 ATP-grasp domain; Region: ATP-grasp; pfam02222 981539000131 adenylosuccinate lyase; Provisional; Region: PRK07492 981539000132 Adenylsuccinate lyase (ASL)_subgroup 1; Region: Adenylsuccinate_lyase_1; cd01360 981539000133 tetramer interface [polypeptide binding]; other site 981539000134 active site 981539000135 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 981539000136 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 981539000137 non-specific DNA binding site [nucleotide binding]; other site 981539000138 salt bridge; other site 981539000139 sequence-specific DNA binding site [nucleotide binding]; other site 981539000140 Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394 981539000141 Low molecular weight phosphatase family; Region: LMWPc; cd00115 981539000142 active site 981539000143 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4642 981539000144 MORN repeat; Region: MORN; cl14787 981539000145 Acyltransferase family; Region: Acyl_transf_3; pfam01757 981539000146 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053 981539000147 active site 981539000148 catalytic triad [active] 981539000149 oxyanion hole [active] 981539000150 Threonine synthase catalyzes the final step of threonine biosynthesis. The conversion of O-phosphohomoserine into threonine and inorganic phosphate is pyridoxal 5'-phosphate dependent. The Thr-synth_1 CD includes members from higher plants; Region: Thr-synth_2; cd01560 981539000151 Threonine synthase [Amino acid transport and metabolism]; Region: ThrC; COG0498 981539000152 pyridoxal 5'-phosphate binding site [chemical binding]; other site 981539000153 catalytic residue [active] 981539000154 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 981539000155 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Thermotoga marina NorM; Region: MATE_NorM_like; cd13137 981539000156 MMPL family; Region: MMPL; pfam03176 981539000157 MMPL family; Region: MMPL; pfam03176 981539000158 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 981539000159 Histidine kinase; Region: HisKA_3; pfam07730 981539000160 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 981539000161 ATP binding site [chemical binding]; other site 981539000162 Mg2+ binding site [ion binding]; other site 981539000163 G-X-G motif; other site 981539000164 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 981539000165 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 981539000166 active site 981539000167 phosphorylation site [posttranslational modification] 981539000168 intermolecular recognition site; other site 981539000169 dimerization interface [polypeptide binding]; other site 981539000170 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 981539000171 DNA binding residues [nucleotide binding] 981539000172 dimerization interface [polypeptide binding]; other site 981539000173 Transcriptional regulator [Transcription]; Region: LysR; COG0583 981539000174 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 981539000175 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 981539000176 dimerization interface [polypeptide binding]; other site 981539000177 30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596 981539000178 50S ribosomal protein L3; Validated; Region: rplC; PRK00001 981539000179 50S ribosomal protein L4; Provisional; Region: rplD; PRK05319 981539000180 50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738 981539000181 50S ribosomal protein L2; Validated; Region: rplB; PRK09374 981539000182 Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181 981539000183 Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947 981539000184 30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357 981539000185 Ribosomal protein L22/L17e. L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit. It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336 981539000186 putative translocon binding site; other site 981539000187 protein-rRNA interface [nucleotide binding]; other site 981539000188 30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310 981539000189 K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3 is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel. The KH...; Region: 30S_S3_KH; cd02412 981539000190 G-X-X-G motif; other site 981539000191 Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189 981539000192 Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433 981539000193 23S rRNA interface [nucleotide binding]; other site 981539000194 5S rRNA interface [nucleotide binding]; other site 981539000195 putative antibiotic binding site [chemical binding]; other site 981539000196 L25 interface [polypeptide binding]; other site 981539000197 L27 interface [polypeptide binding]; other site 981539000198 Ribosomal L29 protein/HIP. L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals. L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427 981539000199 23S rRNA interface [nucleotide binding]; other site 981539000200 putative translocon interaction site; other site 981539000201 signal recognition particle (SRP54) interaction site; other site 981539000202 L23 interface [polypeptide binding]; other site 981539000203 trigger factor interaction site; other site 981539000204 30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610 981539000205 50S ribosomal protein L14; Validated; Region: rplN; PRK05483 981539000206 50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004 981539000207 KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089 981539000208 RNA binding site [nucleotide binding]; other site 981539000209 50S ribosomal protein L5; Validated; Region: rplE; PRK00010 981539000210 Ribosomal protein L5; Region: Ribosomal_L5; pfam00281 981539000211 ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673 981539000212 30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08061 981539000213 30S ribosomal protein S8; Validated; Region: rpsH; PRK00136 981539000214 50S ribosomal protein L6; Validated; Region: rplF; PRK05498 981539000215 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 981539000216 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 981539000217 Ribosomal L18/L5e: L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432 981539000218 5S rRNA interface [nucleotide binding]; other site 981539000219 L27 interface [polypeptide binding]; other site 981539000220 23S rRNA interface [nucleotide binding]; other site 981539000221 L5 interface [polypeptide binding]; other site 981539000222 30S ribosomal protein S5; Validated; Region: rpsE; PRK00550 981539000223 Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333 981539000224 Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719 981539000225 Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins that...; Region: Ribosomal_L30; cd01658 981539000226 23S rRNA binding site [nucleotide binding]; other site 981539000227 50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592 981539000228 preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204 981539000229 SecY translocase; Region: SecY; pfam00344 981539000230 adenylate kinase; Reviewed; Region: adk; PRK00279 981539000231 Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428 981539000232 AMP-binding site [chemical binding]; other site 981539000233 ATP-AMP (Ap5A)-binding site [chemical binding]; other site 981539000234 S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451 981539000235 rRNA binding site [nucleotide binding]; other site 981539000236 predicted 30S ribosome binding site; other site 981539000237 Ribosomal protein L36; Region: Ribosomal_L36; pfam00444 981539000238 Ribosomal protein S13 [Translation, ribosomal structure and biogenesis]; Region: RpsM; COG0099 981539000239 30S ribosomal protein S13; Region: bact_S13; TIGR03631 981539000240 30S ribosomal protein S11; Validated; Region: PRK05309 981539000241 DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182 981539000242 N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928 981539000243 alphaNTD homodimer interface [polypeptide binding]; other site 981539000244 alphaNTD - beta interaction site [polypeptide binding]; other site 981539000245 alphaNTD - beta' interaction site [polypeptide binding]; other site 981539000246 Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118 981539000247 50S ribosomal protein L17; Validated; Region: rplQ; PRK05591 981539000248 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: ipk; PRK00128 981539000249 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 981539000250 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 981539000251 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 981539000252 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 981539000253 putative Zn2+ binding site [ion binding]; other site 981539000254 putative DNA binding site [nucleotide binding]; other site 981539000255 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 981539000256 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 981539000257 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 981539000258 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 981539000259 ABC-ATPase subunit interface; other site 981539000260 dimer interface [polypeptide binding]; other site 981539000261 putative PBP binding regions; other site 981539000262 tyrosyl-tRNA synthetase; Validated; Region: PRK05912 981539000263 catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805 981539000264 active site 981539000265 HIGH motif; other site 981539000266 dimer interface [polypeptide binding]; other site 981539000267 KMSKS motif; other site 981539000268 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 981539000269 RNA binding surface [nucleotide binding]; other site 981539000270 Membrane carboxypeptidase (penicillin-binding protein) [Cell envelope biogenesis, outer membrane]; Region: MrcB; COG0744 981539000271 Transglycosylase; Region: Transgly; pfam00912 981539000272 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 981539000273 DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405 981539000274 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585 981539000275 RNA polymerase Rpb2, domain 2; Region: RNA_pol_Rpb2_2; pfam04561 981539000276 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 981539000277 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 981539000278 RPB1 interaction site [polypeptide binding]; other site 981539000279 RPB12 interaction site [polypeptide binding]; other site 981539000280 RPB10 interaction site [polypeptide binding]; other site 981539000281 RPB11 interaction site [polypeptide binding]; other site 981539000282 RPB3 interaction site [polypeptide binding]; other site 981539000283 RPB12 interaction site [polypeptide binding]; other site 981539000284 DNA-directed RNA polymerase subunit beta'; Provisional; Region: PRK00566 981539000285 RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997 981539000286 RNA polymerase I subunit A N-terminus; Region: RPOLA_N; smart00663 981539000287 RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983 981539000288 RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000 981539000289 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 981539000290 Rpb1 (beta') - Rpb6 (omega) interaction site [polypeptide binding]; other site 981539000291 G-loop; other site 981539000292 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 981539000293 DNA binding site [nucleotide binding] 981539000294 Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site 981539000295 Protein of unknown function (DUF1033); Region: DUF1033; pfam06279 981539000296 Type II/IV secretion system protein; Region: T2SE; pfam00437 981539000297 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 981539000298 Walker A motif; other site 981539000299 ATP binding site [chemical binding]; other site 981539000300 Walker B motif; other site 981539000301 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 981539000302 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 981539000303 Competence protein ComGC [Intracellular trafficking and secretion]; Region: ComGC; COG4537 981539000304 Type II secretory pathway, pseudopilin PulG [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulG; COG2165 981539000305 Type II secretory pathway pseudopilin; Region: PulG; pfam11773 981539000306 Competence protein ComGF [Intracellular trafficking and secretion]; Region: ComGF; COG4940 981539000307 Methyltransferase domain; Region: Methyltransf_31; pfam13847 981539000308 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 981539000309 S-adenosylmethionine binding site [chemical binding]; other site 981539000310 acetate kinase A/propionate kinase 2; Reviewed; Region: PRK00180 981539000311 propionate/acetate kinase; Provisional; Region: PRK12379 981539000312 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 981539000313 non-specific DNA binding site [nucleotide binding]; other site 981539000314 salt bridge; other site 981539000315 sequence-specific DNA binding site [nucleotide binding]; other site 981539000316 CAAX protease self-immunity; Region: Abi; pfam02517 981539000317 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232 981539000318 pyrroline-5-carboxylate reductase; Reviewed; Region: PRK11880 981539000319 Cellulase M and related proteins [Carbohydrate transport and metabolism]; Region: FrvX; COG1363 981539000320 glutamyl aminopeptidase; Region: glu_aminopep; TIGR03107 981539000321 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 981539000322 catalytic residues [active] 981539000323 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 981539000324 putative tRNA-binding site [nucleotide binding]; other site 981539000325 Methyltransferase domain; Region: Methyltransf_31; pfam13847 981539000326 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 981539000327 S-adenosylmethionine binding site [chemical binding]; other site 981539000328 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 981539000329 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 981539000330 dimer interface [polypeptide binding]; other site 981539000331 ssDNA binding site [nucleotide binding]; other site 981539000332 tetramer (dimer of dimers) interface [polypeptide binding]; other site 981539000333 putative selenium metabolism protein, YedE family; Region: seleno_YedE; TIGR04112 981539000334 Sulphur transport; Region: Sulf_transp; pfam04143 981539000335 SirA, YedF, and YeeD. Two-layered alpha/beta sandwich domain. SirA (also known as UvrY, and YhhP) belongs to a family of bacterial two-component response regulators that controls secondary metabolism and virulence. The other member of this...; Region: SirA_YedF_YeeD; cd00291 981539000336 CPxP motif; other site 981539000337 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 981539000338 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 981539000339 active site 981539000340 motif I; other site 981539000341 motif II; other site 981539000342 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 981539000343 Sporulation related domain; Region: SPOR; cl10051 981539000344 Cadherin-like beta sandwich domain; Region: Cadherin-like; pfam12733 981539000345 Glycosyl hydrolases family 32; Region: Glyco_32; smart00640 981539000346 Glycosyl hydrolase family 32, beta-fructosidases; Region: GH32_B_Fructosidase; cd08996 981539000347 substrate binding [chemical binding]; other site 981539000348 active site 981539000349 Glycosyl hydrolases family 32 C terminal; Region: Glyco_hydro_32C; pfam08244 981539000350 Laminin G domain; Region: Laminin_G_2; pfam02210 981539000351 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: RbsB; COG1879 981539000352 Periplasmic sugar-binding domain of active transport systems that are members of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_sugar_binding_like; cd01536 981539000353 ligand binding site [chemical binding]; other site 981539000354 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 981539000355 Histidine kinase; Region: HisKA_3; pfam07730 981539000356 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 981539000357 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 981539000358 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 981539000359 active site 981539000360 phosphorylation site [posttranslational modification] 981539000361 intermolecular recognition site; other site 981539000362 dimerization interface [polypeptide binding]; other site 981539000363 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 981539000364 DNA binding residues [nucleotide binding] 981539000365 dimerization interface [polypeptide binding]; other site 981539000366 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 981539000367 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 981539000368 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cl00025 981539000369 active pocket/dimerization site; other site 981539000370 active site 981539000371 phosphorylation site [posttranslational modification] 981539000372 PTS_IIB, PTS system, Mannose/sorbose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_man; cl00021 981539000373 active site 981539000374 phosphorylation site [posttranslational modification] 981539000375 PTS system sorbose-specific iic component; Region: EII-Sor; pfam03609 981539000376 PTS system mannose/fructose/sorbose family IID component; Region: EIID-AGA; pfam03613 981539000377 Domain of unknown function (DUF4191); Region: DUF4191; pfam13829 981539000378 Type I periplasmic ligand-binding domain of uncharacterized ABC-type transport systems that are predicted to be involved in the uptake of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_uncharacterized_transporter; cd06325 981539000379 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 981539000380 zinc binding site [ion binding]; other site 981539000381 putative ligand binding site [chemical binding]; other site 981539000382 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 981539000383 Transmembrane subunit (TM) of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which are involved in the uptake of branched-chain amino acids (AAs), as well as TMs of transporters involved in the uptake of...; Region: TM_PBP1_branched-chain-AA_like; cd06574 981539000384 TM-ABC transporter signature motif; other site 981539000385 ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: PhnK; COG1101 981539000386 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 981539000387 Walker A/P-loop; other site 981539000388 ATP binding site [chemical binding]; other site 981539000389 Q-loop/lid; other site 981539000390 ABC transporter signature motif; other site 981539000391 Walker B; other site 981539000392 D-loop; other site 981539000393 H-loop/switch region; other site 981539000394 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 981539000395 oligomerisation interface [polypeptide binding]; other site 981539000396 mobile loop; other site 981539000397 roof hairpin; other site 981539000398 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 981539000399 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 981539000400 ring oligomerisation interface [polypeptide binding]; other site 981539000401 ATP/Mg binding site [chemical binding]; other site 981539000402 stacking interactions; other site 981539000403 hinge regions; other site 981539000404 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 981539000405 non-specific DNA binding site [nucleotide binding]; other site 981539000406 salt bridge; other site 981539000407 sequence-specific DNA binding site [nucleotide binding]; other site 981539000408 transcriptional activator, Rgg/GadR/MutR family, C-terminal domain; Region: RGG_Cterm; TIGR01716 981539000409 Predicted membrane protein [Function unknown]; Region: COG4640 981539000410 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 981539000411 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 981539000412 active site 981539000413 Transglycosylase; Region: Transgly; pfam00912 981539000414 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 981539000415 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 981539000416 Preprotein translocase subunit SecE [Intracellular trafficking and secretion]; Region: SecE; COG0690 981539000417 transcription antitermination protein NusG; Validated; Region: nusG; PRK05609 981539000418 Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891 981539000419 putative homodimer interface [polypeptide binding]; other site 981539000420 NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091 981539000421 heterodimer interface [polypeptide binding]; other site 981539000422 homodimer interface [polypeptide binding]; other site 981539000423 Ion transport protein; Region: Ion_trans; pfam00520 981539000424 Ion channel; Region: Ion_trans_2; pfam07885 981539000425 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: COG4667 981539000426 Hypothetical patatin similar to yjju protein of Escherichia coli; Region: Pat_hypo_Ecoli_yjju_like; cd07208 981539000427 active site 981539000428 nucleophile elbow; other site 981539000429 leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390 981539000430 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 981539000431 HIGH motif; other site 981539000432 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 981539000433 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 981539000434 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 981539000435 active site 981539000436 KMSKS motif; other site 981539000437 Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958 981539000438 tRNA binding surface [nucleotide binding]; other site 981539000439 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 981539000440 galactose mutarotase_like; Region: galactose_mutarotase_like; cd09019 981539000441 active site 981539000442 catalytic residues [active] 981539000443 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 981539000444 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 981539000445 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 981539000446 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 981539000447 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 981539000448 RelB antitoxin; Region: RelB; cl01171 981539000449 Domain of unknown function (DUF955); Region: DUF955; pfam06114 981539000450 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 981539000451 non-specific DNA binding site [nucleotide binding]; other site 981539000452 salt bridge; other site 981539000453 sequence-specific DNA binding site [nucleotide binding]; other site 981539000454 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 981539000455 Domain of unknown function (DUF4160); Region: DUF4160; pfam13711 981539000456 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 981539000457 catalytic residues [active] 981539000458 putative cross-wall-targeting lipoprotein signal; Region: strep_RK_lipo; TIGR03726 981539000459 LPXTG-motif cell wall anchor domain; Region: LPXTG_anchor; TIGR01167 981539000460 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 981539000461 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 981539000462 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 981539000463 non-specific DNA binding site [nucleotide binding]; other site 981539000464 salt bridge; other site 981539000465 sequence-specific DNA binding site [nucleotide binding]; other site 981539000466 Replication initiation factor; Region: Rep_trans; pfam02486 981539000467 Antirestriction protein (ArdA); Region: ArdA; cl01953 981539000468 Antitoxin Phd_YefM, type II toxin-antitoxin system; Region: PhdYeFM_antitox; pfam02604 981539000469 Plasmid encoded toxin Txe; Region: Plasmid_Txe; cl17389 981539000470 Conjugative transposon protein TcpC; Region: TpcC; pfam12642 981539000471 TcpE family; Region: TcpE; pfam12648 981539000472 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 981539000473 AAA-like domain; Region: AAA_10; pfam12846 981539000474 truncated ICESt1 ORFC hypothetical protein 981539000475 truncated ICESt1 ORFC hypothetical protein 981539000476 CHAP domain; Region: CHAP; cl17642 981539000477 Sortase A (SrtA) or subfamily-1 sortases are cysteine transpeptidases found in gram-positive bacteria that anchor surface proteins to peptidoglycans of the bacterial cell wall envelope. They do so by catalyzing a transpeptidation reaction in which the...; Region: Sortase_A_1; cd06165 981539000478 active site 981539000479 catalytic site [active] 981539000480 Domain of unknown function (DUF771); Region: DUF771; pfam05595 981539000481 Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582 981539000482 phiLC3 phage and phage-related integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes various bacterial (mainly gram positive) and phage integrases, including those similar to Lactococcus...; Region: INT_phiLC3_C; cd01189 981539000483 Int/Topo IB signature motif; other site 981539000484 recombination factor protein RarA; Reviewed; Region: PRK13342 981539000485 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 981539000486 Walker A motif; other site 981539000487 ATP binding site [chemical binding]; other site 981539000488 Walker B motif; other site 981539000489 arginine finger; other site 981539000490 MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002 981539000491 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 981539000492 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 981539000493 Coenzyme A binding pocket [chemical binding]; other site 981539000494 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 981539000495 Protein of unknown function (DUF3013); Region: DUF3013; pfam11217 981539000496 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 981539000497 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 981539000498 Coenzyme A binding pocket [chemical binding]; other site 981539000499 GNAT acetyltransferase 2; Region: GNAT_acetyltr_2; pfam13718 981539000500 Ribosomal protein L11 methyltransferase (PrmA); Region: PrmA; pfam06325 981539000501 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 981539000502 S-adenosylmethionine binding site [chemical binding]; other site 981539000503 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1385 981539000504 RNA methyltransferase, RsmE family; Region: TIGR00046 981539000505 Transcriptional regulators [Transcription]; Region: PurR; COG1609 981539000506 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 981539000507 DNA binding site [nucleotide binding] 981539000508 domain linker motif; other site 981539000509 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 981539000510 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 981539000511 PTS system, IIBC component; Region: PTS-II-BC-unk1; TIGR02003 981539000512 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 981539000513 active site turn [active] 981539000514 phosphorylation site [posttranslational modification] 981539000515 Phosphotransferase system IIA components [Carbohydrate transport and metabolism]; Region: NagE; COG2190 981539000516 HPr interaction site; other site 981539000517 glycerol kinase (GK) interaction site [polypeptide binding]; other site 981539000518 active site 981539000519 phosphorylation site [posttranslational modification] 981539000520 Streptococcus agalactiae RgfB, part of a putative two component signal transduction system, and related proteins; Region: RgfB-like; cd09079 981539000521 putative catalytic site [active] 981539000522 putative metal binding site [ion binding]; other site 981539000523 putative phosphate binding site [ion binding]; other site 981539000524 Cellulase M and related proteins [Carbohydrate transport and metabolism]; Region: FrvX; COG1363 981539000525 M42 Peptidase, Endoglucanase-like subfamily; Region: M42_glucanase_like; cd05657 981539000526 putative oligomer interface [polypeptide binding]; other site 981539000527 putative active site [active] 981539000528 metal binding site [ion binding]; metal-binding site 981539000529 flavoprotein NrdI; Provisional; Region: PRK02551 981539000530 cellobiose phosphotransferase system IIB component; Reviewed; Region: celB; PRK09590 981539000531 active site 981539000532 P-loop; other site 981539000533 phosphorylation site [posttranslational modification] 981539000534 PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_lac; cd00215 981539000535 methionine cluster; other site 981539000536 active site 981539000537 phosphorylation site [posttranslational modification] 981539000538 metal binding site [ion binding]; metal-binding site 981539000539 Beta-glucosidase/6-phospho-beta-glucosidase/beta- galactosidase [Carbohydrate transport and metabolism]; Region: BglB; COG2723 981539000540 beta-galactosidase; Region: BGL; TIGR03356 981539000541 Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455 981539000542 cellobiose phosphotransferase system IIC component; Reviewed; Region: celD; PRK09592 981539000543 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 981539000544 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 981539000545 DNA-binding site [nucleotide binding]; DNA binding site 981539000546 The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; Region: UTRA; smart00866 981539000547 Phosphomannose isomerase [Carbohydrate transport and metabolism]; Region: ManA; COG1482 981539000548 mannose-6-phosphate isomerase, class I; Region: manA; TIGR00218 981539000549 Aspartate alpha-decarboxylase or L-aspartate 1-decarboxylase, a pyruvoyl group-dependent decarboxylase in beta-alanine production; Region: Asp_decarbox; cd06919 981539000550 tetramerization interface [polypeptide binding]; other site 981539000551 active site 981539000552 Pantoate-beta-alanine ligase; Region: PanC; cd00560 981539000553 pantoate--beta-alanine ligase; Region: panC; TIGR00018 981539000554 active site 981539000555 ATP-binding site [chemical binding]; other site 981539000556 pantoate-binding site; other site 981539000557 HXXH motif; other site 981539000558 Ketopantoate hydroxymethyltransferase (KPHMT) is the first enzyme in the pantothenate biosynthesis pathway. Ketopantoate hydroxymethyltransferase (KPHMT) catalyzes the first committed step in the biosynthesis of pantothenate (vitamin B5), which is a...; Region: KPHMT-like; cd06557 981539000559 oligomerization interface [polypeptide binding]; other site 981539000560 active site 981539000561 metal binding site [ion binding]; metal-binding site 981539000562 Ricin-type beta-trefoil lectin domain; Region: Ricin_B_lectin; pfam00652 981539000563 Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific...; Region: RICIN; cd00161 981539000564 putative sugar binding sites [chemical binding]; other site 981539000565 Q-X-W motif; other site 981539000566 Cellulase (glycosyl hydrolase family 5); Region: Cellulase; pfam00150 981539000567 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 981539000568 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 981539000569 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 981539000570 dimer interface [polypeptide binding]; other site 981539000571 conserved gate region; other site 981539000572 putative PBP binding loops; other site 981539000573 ABC-ATPase subunit interface; other site 981539000574 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 981539000575 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 981539000576 dimer interface [polypeptide binding]; other site 981539000577 conserved gate region; other site 981539000578 ABC-ATPase subunit interface; other site 981539000579 Alpha-galactosidase [Carbohydrate transport and metabolism]; Region: GalA; COG3345 981539000580 Melibiase; Region: Melibiase; pfam02065 981539000581 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 981539000582 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 981539000583 DNA-binding site [nucleotide binding]; DNA binding site 981539000584 The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; Region: UTRA; smart00866 981539000585 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 981539000586 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 981539000587 nucleotide binding site [chemical binding]; other site 981539000588 SGNH_hydrolase subfamily. SGNH hydrolases are a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site...; Region: SGNH_hydrolase_like_2; cd01834 981539000589 active site 981539000590 catalytic triad [active] 981539000591 oxyanion hole [active] 981539000592 Acetyl xylan esterase (AXE1); Region: AXE1; pfam05448 981539000593 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 981539000594 HD domain; Region: HD_4; pfam13328 981539000595 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 981539000596 synthetase active site [active] 981539000597 NTP binding site [chemical binding]; other site 981539000598 metal binding site [ion binding]; metal-binding site 981539000599 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 981539000600 ACT domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876 981539000601 D-Tyrosyl-tRNAtyr deacylases; a class of tRNA-dependent hydrolases which are capable of hydrolyzing the ester bond of D-Tyrosyl-tRNA reducing the level of cellular D-Tyrosine while recycling the peptidyl-tRNA; found in bacteria and in eukaryotes but not...; Region: Dtyr_deacylase; cd00563 981539000602 putative active site [active] 981539000603 dimerization interface [polypeptide binding]; other site 981539000604 putative tRNAtyr binding site [nucleotide binding]; other site 981539000605 Regulator of polyketide synthase expression [Signal transduction mechanisms / Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2508 981539000606 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 981539000607 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 981539000608 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 981539000609 Walker A/P-loop; other site 981539000610 ATP binding site [chemical binding]; other site 981539000611 Q-loop/lid; other site 981539000612 ABC transporter signature motif; other site 981539000613 Walker B; other site 981539000614 D-loop; other site 981539000615 H-loop/switch region; other site 981539000616 TOBE domain; Region: TOBE_2; pfam08402 981539000617 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 981539000618 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 981539000619 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 981539000620 Ribose/Galactose Isomerase; Region: LacAB_rpiB; cl00485 981539000621 galactose-6-phosphate isomerase subunit LacB; Reviewed; Region: PRK08622 981539000622 1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164 981539000623 tagatose-6-phosphate kinase; Region: lacC; TIGR01231 981539000624 putative substrate binding site [chemical binding]; other site 981539000625 putative ATP binding site [chemical binding]; other site 981539000626 tagatose 1,6-diphosphate aldolase; Reviewed; Region: PRK12399 981539000627 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 981539000628 active site 981539000629 phosphorylation site [posttranslational modification] 981539000630 Phosphotransferase system, galactitol-specific IIB component [Carbohydrate transport and metabolism]; Region: SgaB; COG3414 981539000631 active site 981539000632 P-loop; other site 981539000633 phosphorylation site [posttranslational modification] 981539000634 Phosphotransferase system, galactitol-specific IIC component [Carbohydrate transport and metabolism]; Region: GatC; COG3775 981539000635 PTS system sugar-specific permease component; Region: EIIC-GAT; pfam03611 981539000636 Aldose 1-epimerase, similar to Lactococcus lactis lacX; Region: Aldose_epim_lacX; cd09024 981539000637 active site 981539000638 catalytic residues [active] 981539000639 transcriptional antiterminator BglG; Provisional; Region: PRK09772 981539000640 CAT RNA binding domain; Region: CAT_RBD; smart01061 981539000641 PRD domain; Region: PRD; pfam00874 981539000642 PRD domain; Region: PRD; pfam00874 981539000643 6-phospho-beta-galactosidase; Provisional; Region: PRK13511 981539000644 beta-galactosidase; Region: BGL; TIGR03356 981539000645 PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_lac; cd00215 981539000646 methionine cluster; other site 981539000647 active site 981539000648 phosphorylation site [posttranslational modification] 981539000649 metal binding site [ion binding]; metal-binding site 981539000650 Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; cl17295 981539000651 Phosphotransferase system, EIIC; Region: PTS_EIIC; pfam02378 981539000652 PTS_IIB: subunit IIB of enzyme II (EII) is the central energy-coupling domain of the phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In the multienzyme PTS complex, EII is a carbohydrate-specific permease consisting of two cytoplasmic...; Region: PTS_IIB; cl10014 981539000653 active site 981539000654 P-loop; other site 981539000655 phosphorylation site [posttranslational modification] 981539000656 Glycosyl hydrolase family 53; Region: Glyco_hydro_53; cl06672 981539000657 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 981539000658 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 981539000659 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 981539000660 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 981539000661 Alpha-galactosidase [Carbohydrate transport and metabolism]; Region: GalA; COG3345 981539000662 Melibiase; Region: Melibiase; pfam02065 981539000663 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 981539000664 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 981539000665 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 981539000666 dimer interface [polypeptide binding]; other site 981539000667 conserved gate region; other site 981539000668 putative PBP binding loops; other site 981539000669 ABC-ATPase subunit interface; other site 981539000670 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 981539000671 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 981539000672 dimer interface [polypeptide binding]; other site 981539000673 conserved gate region; other site 981539000674 putative PBP binding loops; other site 981539000675 ABC-ATPase subunit interface; other site 981539000676 sucrose phosphorylase; Region: sucrose_gtfA; TIGR03852 981539000677 Alpha amylase catalytic domain found in sucrose phosphorylase (also called sucrose glucosyltransferase, disaccharide glucosyltransferase, and sucrose-phosphate alpha-D glucosyltransferase); Region: AmyAc_Sucrose_phosphorylase; cd11355 981539000678 active site 981539000679 homodimer interface [polypeptide binding]; other site 981539000680 catalytic site [active] 981539000681 alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403 981539000682 Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333 981539000683 Ca binding site [ion binding]; other site 981539000684 active site 981539000685 catalytic site [active] 981539000686 Domain of unknown function (DUF3459); Region: DUF3459; pfam11941 981539000687 DNA-binding transcriptional repressor EbgR; Provisional; Region: PRK10339 981539000688 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 981539000689 DNA binding site [nucleotide binding] 981539000690 Ligand-binding domain of DNA transcription repressor GalR which is one of two regulatory proteins involved in galactose transport and metabolism; Region: PBP1_GalR; cd01544 981539000691 putative dimerization interface [polypeptide binding]; other site 981539000692 putative ligand binding site [chemical binding]; other site 981539000693 galactokinase; Provisional; Region: PRK05322 981539000694 Galactokinase galactose-binding signature; Region: GalKase_gal_bdg; pfam10509 981539000695 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 981539000696 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 981539000697 galactose-1-phosphate uridylyltransferase; Provisional; Region: PRK05270 981539000698 Galactose-1-phosphate uridyl transferase, N-terminal domain; Region: GalP_UDP_transf; pfam01087 981539000699 Galactose-1-phosphate uridyl transferase, C-terminal domain; Region: GalP_UDP_tr_C; pfam02744 981539000700 UDP-glucose 4-epimerase [Cell envelope biogenesis, outer membrane]; Region: GalE; COG1087 981539000701 UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247 981539000702 NAD binding site [chemical binding]; other site 981539000703 homodimer interface [polypeptide binding]; other site 981539000704 active site 981539000705 substrate binding site [chemical binding]; other site 981539000706 mycothiol synthase; Region: mycothiol_MshD; TIGR03448 981539000707 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 981539000708 Coenzyme A binding pocket [chemical binding]; other site 981539000709 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 981539000710 Coenzyme A binding pocket [chemical binding]; other site 981539000711 preprotein translocase subunit YajC; Validated; Region: yajC; PRK06531 981539000712 Undecaprenyl pyrophosphate synthase [Lipid metabolism]; Region: UppS; COG0020 981539000713 Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cd00475 981539000714 catalytic residue [active] 981539000715 putative FPP diphosphate binding site; other site 981539000716 putative FPP binding hydrophobic cleft; other site 981539000717 dimer interface [polypeptide binding]; other site 981539000718 putative IPP diphosphate binding site; other site 981539000719 CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575 981539000720 Cytidylyltransferase family; Region: CTP_transf_1; pfam01148 981539000721 RIP metalloprotease RseP; Region: TIGR00054 981539000722 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 981539000723 active site 981539000724 Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020 981539000725 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 981539000726 protein binding site [polypeptide binding]; other site 981539000727 Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020 981539000728 Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020 981539000729 putative substrate binding region [chemical binding]; other site 981539000730 putative substrate binding region [chemical binding]; other site 981539000731 prolyl-tRNA synthetase; Provisional; Region: PRK09194 981539000732 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 981539000733 motif 1; other site 981539000734 dimer interface [polypeptide binding]; other site 981539000735 active site 981539000736 motif 2; other site 981539000737 INS is an amino acid-editing domain inserted (INS) into the bacterial class II prolyl-tRNA synthetase (ProRS) however, this CD is not exclusively bacterial. It is also found at the N-terminus of the eukaryotic/archaea-like ProRS's of yeasts and...; Region: ProRS-INS; cd04334 981539000738 putative deacylase active site [active] 981539000739 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 981539000740 active site 981539000741 motif 3; other site 981539000742 ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding; Region: ProRS_anticodon_short; cd00861 981539000743 anticodon binding site; other site 981539000744 DNA polymerase III PolC; Validated; Region: polC; PRK00448 981539000745 DNA polymerase III polC-type N-terminus; Region: DNA_pol3_alph_N; pfam11490 981539000746 polC_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold nucleic acid binding domain of Bacillus subtilis type C replicative DNA polymerase III alpha subunit (polC). Replication in B. subtilis and Staphylococcus aureus requires two...; Region: polC_OBF; cd04484 981539000747 generic binding surface II; other site 981539000748 generic binding surface I; other site 981539000749 Polymerase and Histidinol Phosphatase domain; Region: PHP; cl17102 981539000750 active site 981539000751 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 981539000752 active site 981539000753 catalytic site [active] 981539000754 substrate binding site [chemical binding]; other site 981539000755 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III at PolC gene; Region: PHP_PolIIIA_POLC; cd07435 981539000756 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 981539000757 MarR family; Region: MarR; pfam01047 981539000758 MarR family; Region: MarR_2; cl17246 981539000759 Predicted flavoprotein [General function prediction only]; Region: COG0431 981539000760 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 981539000761 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 981539000762 active site 981539000763 catalytic residues [active] 981539000764 metal binding site [ion binding]; metal-binding site 981539000765 DNA-binding transcriptional activator YeiL; Provisional; Region: PRK10402 981539000766 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 981539000767 ligand binding site [chemical binding]; other site 981539000768 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cl17320 981539000769 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 981539000770 Major Facilitator Superfamily; Region: MFS_1; pfam07690 981539000771 putative substrate translocation pore; other site 981539000772 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 981539000773 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 981539000774 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 981539000775 putative active site [active] 981539000776 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_3; cd07241 981539000777 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 981539000778 putative metal binding site [ion binding]; other site 981539000779 Cof subfamily of IIB subfamily of haloacid dehalogenase superfamily; Region: Cof-subfamily; TIGR00099 981539000780 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 981539000781 active site 981539000782 motif I; other site 981539000783 motif II; other site 981539000784 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 981539000785 Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353 981539000786 16S/18S rRNA binding site [nucleotide binding]; other site 981539000787 S13e-L30e interaction site [polypeptide binding]; other site 981539000788 25S rRNA binding site [nucleotide binding]; other site 981539000789 bifunctional acetaldehyde-CoA/alcohol dehydrogenase; Provisional; Region: PRK13805 981539000790 Coenzyme A acylating aldehyde dehydrogenase (ACDH), ALDH family 20-like; Region: ALDH_F20_ACDH; cd07122 981539000791 putative catalytic cysteine [active] 981539000792 C-terminal alcohol dehydrogenase domain of the acetaldehyde dehydrogenase-alcohol dehydrogenase bifunctional two-domain protein (AAD); Region: AAD_C; cd08178 981539000793 putative active site [active] 981539000794 metal binding site [ion binding]; metal-binding site 981539000795 Predicted membrane protein [Function unknown]; Region: COG2261 981539000796 polynucleotide phosphorylase/polyadenylase; Provisional; Region: PRK11824 981539000797 Polyribonucleotide nucleotidyltransferase, repeat 1; Region: RNase_PH_PNPase_1; cd11363 981539000798 RNase E interface [polypeptide binding]; other site 981539000799 trimer interface [polypeptide binding]; other site 981539000800 Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364 981539000801 RNase E interface [polypeptide binding]; other site 981539000802 trimer interface [polypeptide binding]; other site 981539000803 active site 981539000804 Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393 981539000805 S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472 981539000806 RNA binding site [nucleotide binding]; other site 981539000807 Serine acetyltransferase [Amino acid transport and metabolism]; Region: CysE; COG1045 981539000808 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354 981539000809 trimer interface [polypeptide binding]; other site 981539000810 active site 981539000811 substrate binding site [chemical binding]; other site 981539000812 CoA binding site [chemical binding]; other site 981539000813 cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260 981539000814 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 981539000815 active site 981539000816 HIGH motif; other site 981539000817 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 981539000818 KMSKS motif; other site 981539000819 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 981539000820 tRNA binding surface [nucleotide binding]; other site 981539000821 anticodon binding site; other site 981539000822 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 981539000823 active site 981539000824 metal binding site [ion binding]; metal-binding site 981539000825 dimerization interface [polypeptide binding]; other site 981539000826 rRNA methylase, putative, group 3; Region: rRNA_methyl_3; TIGR00186 981539000827 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032 981539000828 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 981539000829 YacP-like NYN domain; Region: NYN_YacP; cl01491 981539000830 EDD domain protein, DegV family; Region: DegV; TIGR00762 981539000831 Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645 981539000832 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 981539000833 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 981539000834 non-specific DNA binding site [nucleotide binding]; other site 981539000835 salt bridge; other site 981539000836 sequence-specific DNA binding site [nucleotide binding]; other site 981539000837 Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558 981539000838 2-dehydropantoate 2-reductase; Reviewed; Region: PRK06522 981539000839 Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546 981539000840 Ribosomal protein L13. Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392 981539000841 23S rRNA interface [nucleotide binding]; other site 981539000842 L3 interface [polypeptide binding]; other site 981539000843 30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132 981539000844 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 981539000845 active site 981539000846 catalytic residues [active] 981539000847 DNA binding site [nucleotide binding] 981539000848 Int/Topo IB signature motif; other site 981539000849 Helix-turn-helix domain; Region: HTH_17; pfam12728 981539000850 PemK-like protein; Region: PemK; pfam02452 981539000851 RelB antitoxin; Region: RelB; cl01171 981539000852 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 981539000853 catalytic residue [active] 981539000854 CHAP domain; Region: CHAP; pfam05257 981539000855 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 981539000856 AAA-like domain; Region: AAA_10; pfam12846 981539000857 TcpE family; Region: TcpE; pfam12648 981539000858 Conjugative transposon protein TcpC; Region: TpcC; pfam12642 981539000859 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 981539000860 non-specific DNA binding site [nucleotide binding]; other site 981539000861 salt bridge; other site 981539000862 sequence-specific DNA binding site [nucleotide binding]; other site 981539000863 Putative phage replication protein RstA [DNA replication, recombination, and repair]; Region: COG2946 981539000864 Replication initiation factor; Region: Rep_trans; pfam02486 981539000865 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 981539000866 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3041 981539000867 RelB antitoxin; Region: RelB; cl01171 981539000868 PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in bacteria and archaea; Region: PEBP_bact_arch; cd00865 981539000869 substrate binding site [chemical binding]; other site 981539000870 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 981539000871 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 981539000872 non-specific DNA binding site [nucleotide binding]; other site 981539000873 salt bridge; other site 981539000874 sequence-specific DNA binding site [nucleotide binding]; other site 981539000875 Domain of unknown function (DUF955); Region: DUF955; pfam06114 981539000876 KAP family P-loop domain; Region: KAP_NTPase; pfam07693 981539000877 Site-specific DNA methylase [DNA replication, recombination, and repair]; Region: Dcm; COG0270 981539000878 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315 981539000879 cofactor binding site; other site 981539000880 DNA binding site [nucleotide binding] 981539000881 substrate interaction site [chemical binding]; other site 981539000882 Site-specific DNA methylase [DNA replication, recombination, and repair]; Region: Dcm; COG0270 981539000883 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315 981539000884 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 981539000885 non-specific DNA binding site [nucleotide binding]; other site 981539000886 salt bridge; other site 981539000887 sequence-specific DNA binding site [nucleotide binding]; other site 981539000888 Cro/C1-type HTH DNA-binding domain; Region: HTH_26; pfam13443 981539000889 sequence-specific DNA binding site [nucleotide binding]; other site 981539000890 salt bridge; other site 981539000891 Domain of unknown function (DUF4297); Region: DUF4297; pfam14130 981539000892 Chromosome segregation ATPases [Cell division and chromosome partitioning]; Region: Smc; COG1196 981539000893 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 981539000894 ACT domain proteins similar to the yet uncharacterized Streptococcus pneumoniae ACT domain protein; Region: ACT_1ZPV; cd04872 981539000895 Uncharacterized proteins with similarity to Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL_like_DUF711; cd08025 981539000896 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 981539000897 catalytic core [active] 981539000898 D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: VanY; COG1876 981539000899 D-alanyl-D-alanine carboxypeptidase; Region: VanY; pfam02557 981539000900 Mannosyl-glycoprotein endo-beta-N-acetylglucosaminidase; Region: Glucosaminidase; cl17361 981539000901 heat-inducible transcription repressor; Provisional; Region: hrcA; PRK00082 981539000902 GrpE; Region: GrpE; pfam01025 981539000903 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446 981539000904 dimer interface [polypeptide binding]; other site 981539000905 hsp70 (ATPase domain) interactions [polypeptide binding]; other site 981539000906 molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290 981539000907 Nucleotide-binding domain of human HSPA9 and similar proteins; Region: HSPA9-Ssq1-like_NBD; cd10234 981539000908 nucleotide binding site [chemical binding]; other site 981539000909 NEF interaction site [polypeptide binding]; other site 981539000910 SBD interface [polypeptide binding]; other site 981539000911 Putative intracellular protease/amidase [General function prediction only]; Region: ThiJ; COG0693 981539000912 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 981539000913 conserved cys residue [active] 981539000914 chaperone protein DnaJ; Provisional; Region: PRK14276 981539000915 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 981539000916 HSP70 interaction site [polypeptide binding]; other site 981539000917 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cl03262 981539000918 substrate binding site [polypeptide binding]; other site 981539000919 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 981539000920 Zn binding sites [ion binding]; other site 981539000921 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 981539000922 dimer interface [polypeptide binding]; other site 981539000923 tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021 981539000924 Eukaryotic and bacterial pseudouridine synthases similar to E. coli TruA; Region: PseudoU_synth_EcTruA; cd02570 981539000925 dimerization interface 3.5A [polypeptide binding]; other site 981539000926 active site 981539000927 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 981539000928 dimer interface [polypeptide binding]; other site 981539000929 substrate binding site [chemical binding]; other site 981539000930 ATP binding site [chemical binding]; other site 981539000931 ECF-type riboflavin transporter, S component; Region: ECF-ribofla_trS; pfam07155 981539000932 Protein of unknown function (DUF3816); Region: DUF3816; pfam12822 981539000933 hypothetical protein; Provisional; Region: PRK13690 981539000934 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 981539000935 Mechanosensitive ion channel; Region: MS_channel; pfam00924 981539000936 trigger factor; Provisional; Region: tig; PRK01490 981539000937 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 981539000938 Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698 981539000939 DNA-directed RNA polymerase delta subunit; Region: RNA_pol_delta; pfam05066 981539000940 CTP synthetase; Validated; Region: pyrG; PRK05380 981539000941 CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113 981539000942 Catalytic site [active] 981539000943 active site 981539000944 UTP binding site [chemical binding]; other site 981539000945 Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746 981539000946 active site 981539000947 putative oxyanion hole; other site 981539000948 catalytic triad [active] 981539000949 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 981539000950 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 981539000951 fructose-bisphosphate aldolase; Provisional; Region: PRK09197 981539000952 Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947 981539000953 intersubunit interface [polypeptide binding]; other site 981539000954 active site 981539000955 zinc binding site [ion binding]; other site 981539000956 Na+ binding site [ion binding]; other site 981539000957 50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359 981539000958 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1302 981539000959 DAK2 domain fusion protein YloV; Region: YloV; TIGR03599 981539000960 DAK2 domain; Region: Dak2; pfam02734 981539000961 dihydroxy-acid dehydratase; Provisional; Region: PRK00911 981539000962 6-phosphogluconate dehydratase; Region: edd; TIGR01196 981539000963 acetolactate synthase catalytic subunit; Reviewed; Region: PRK07282 981539000964 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 981539000965 PYR/PP interface [polypeptide binding]; other site 981539000966 dimer interface [polypeptide binding]; other site 981539000967 TPP binding site [chemical binding]; other site 981539000968 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 981539000969 Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015 981539000970 TPP-binding site [chemical binding]; other site 981539000971 dimer interface [polypeptide binding]; other site 981539000972 acetolactate synthase 3 regulatory subunit; Reviewed; Region: ilvH; PRK11895 981539000973 N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878 981539000974 putative valine binding site [chemical binding]; other site 981539000975 dimer interface [polypeptide binding]; other site 981539000976 Small subunit of acetolactate synthase; Region: ALS_ss_C; pfam10369 981539000977 ketol-acid reductoisomerase; Provisional; Region: PRK05479 981539000978 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvN; pfam07991 981539000979 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450 981539000980 threonine dehydratase; Validated; Region: PRK08639 981539000981 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 981539000982 tetramer interface [polypeptide binding]; other site 981539000983 pyridoxal 5'-phosphate binding site [chemical binding]; other site 981539000984 catalytic residue [active] 981539000985 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 981539000986 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 981539000987 A subgroup of the band 7 domain of flotillin (reggie) like proteins. This subgroup contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin. Many of these band 7 domain-containing proteins are lipid raft-associated. Individual...; Region: Band_7_4; cd03407 981539000988 VanZ like family; Region: VanZ; pfam04892 981539000989 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 981539000990 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 981539000991 Walker A/P-loop; other site 981539000992 ATP binding site [chemical binding]; other site 981539000993 Q-loop/lid; other site 981539000994 ABC transporter signature motif; other site 981539000995 Walker B; other site 981539000996 D-loop; other site 981539000997 H-loop/switch region; other site 981539000998 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 981539000999 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 981539001000 substrate binding pocket [chemical binding]; other site 981539001001 membrane-bound complex binding site; other site 981539001002 hinge residues; other site 981539001003 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 981539001004 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 981539001005 dimer interface [polypeptide binding]; other site 981539001006 conserved gate region; other site 981539001007 putative PBP binding loops; other site 981539001008 ABC-ATPase subunit interface; other site 981539001009 Predicted membrane protein (DUF2207); Region: DUF2207; pfam09972 981539001010 undecaprenyl pyrophosphate phosphatase; Reviewed; Region: PRK00281 981539001011 adaptor protein; Provisional; Region: PRK02315 981539001012 UDP-N-acetylmuramyl pentapeptide phosphotransferase/UDP-N- acetylglucosamine-1-phosphate transferase [Cell envelope biogenesis, outer membrane]; Region: Rfe; COG0472 981539001013 This subfamily contains Escherichia coli WecA, Bacillus subtilis TagO and related proteins. WecA is an UDP-N-acetylglucosamine (GlcNAc):undecaprenyl-phosphate (Und-P) GlcNAc-1-phosphate transferase that catalyzes the formation of a phosphodiester bond...; Region: GT_WecA_like; cd06853 981539001014 Mg++ binding site [ion binding]; other site 981539001015 putative catalytic motif [active] 981539001016 substrate binding site [chemical binding]; other site 981539001017 Cysteine desulfurase activator ATPase [Posttranslational modification, protein turnover, chaperones]; Region: sufC; COG0396 981539001018 ABC-type transport system involved in Fe-S cluster assembly, ATPase component; Region: ABC_FeS_Assembly; cd03217 981539001019 Walker A/P-loop; other site 981539001020 ATP binding site [chemical binding]; other site 981539001021 Q-loop/lid; other site 981539001022 ABC transporter signature motif; other site 981539001023 Walker B; other site 981539001024 D-loop; other site 981539001025 H-loop/switch region; other site 981539001026 Cysteine desulfurase activator SufB [Posttranslational modification, protein turnover, chaperones]; Region: SufB; COG0719 981539001027 cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814; cl03223 981539001028 FeS assembly protein SufD; Region: sufD; TIGR01981 981539001029 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 981539001030 Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453 981539001031 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 981539001032 catalytic residue [active] 981539001033 NifU homolog involved in Fe-S cluster formation [Energy production and conversion]; Region: IscU; COG0822 981539001034 Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664 981539001035 trimerization site [polypeptide binding]; other site 981539001036 active site 981539001037 cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814; cl03223 981539001038 FeS assembly protein SufB; Region: sufB; TIGR01980 981539001039 D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: DacC; COG1686 981539001040 Beta-lactamase; Region: Beta-lactamase; cl17358 981539001041 Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; smart00936 981539001042 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 981539001043 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 981539001044 peptide binding site [polypeptide binding]; other site 981539001045 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 981539001046 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 981539001047 dimer interface [polypeptide binding]; other site 981539001048 conserved gate region; other site 981539001049 putative PBP binding loops; other site 981539001050 ABC-ATPase subunit interface; other site 981539001051 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 981539001052 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 981539001053 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 981539001054 dimer interface [polypeptide binding]; other site 981539001055 conserved gate region; other site 981539001056 putative PBP binding loops; other site 981539001057 ABC-ATPase subunit interface; other site 981539001058 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 981539001059 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 981539001060 Walker A/P-loop; other site 981539001061 ATP binding site [chemical binding]; other site 981539001062 Q-loop/lid; other site 981539001063 ABC transporter signature motif; other site 981539001064 Walker B; other site 981539001065 D-loop; other site 981539001066 H-loop/switch region; other site 981539001067 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 981539001068 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 981539001069 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 981539001070 Walker A/P-loop; other site 981539001071 ATP binding site [chemical binding]; other site 981539001072 Q-loop/lid; other site 981539001073 ABC transporter signature motif; other site 981539001074 Walker B; other site 981539001075 D-loop; other site 981539001076 H-loop/switch region; other site 981539001077 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352 981539001078 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 981539001079 Endoglucanase [Carbohydrate transport and metabolism]; Region: BglC; COG2730 981539001080 Cellulase (glycosyl hydrolase family 5); Region: Cellulase; pfam00150 981539001081 aspartate kinase; Reviewed; Region: PRK09034 981539001082 AAK_AKiii-YclM-BS: Amino Acid Kinase Superfamily (AAK), AKiii-YclM-BS; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the lysine plus threonine-sensitive aspartokinase isoenzyme AKIII, a monofunctional class enzyme found in...; Region: AAK_AKiii-YclM-BS; cd04245 981539001083 putative catalytic residues [active] 981539001084 putative nucleotide binding site [chemical binding]; other site 981539001085 putative aspartate binding site [chemical binding]; other site 981539001086 ACT domains located C-terminal to the catalytic domain of the lysine plus threonine-sensitive aspartokinase isoenzyme AKIII; Region: ACT_AKiii-YclM-BS_1; cd04911 981539001087 allosteric regulatory residue; other site 981539001088 ACT domains located C-terminal to the catalytic domain of the lysine plus threonine-sensitive aspartokinase isoenzyme AKIII; Region: ACT_AKiii-YclM-BS_2; cd04916 981539001089 Predicted phosphatase/phosphohexomutase [General function prediction only]; Region: COG0637 981539001090 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 981539001091 motif II; other site 981539001092 enoyl-CoA hydratase; Provisional; Region: PRK07260 981539001093 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 981539001094 substrate binding site [chemical binding]; other site 981539001095 oxyanion hole (OAH) forming residues; other site 981539001096 trimer interface [polypeptide binding]; other site 981539001097 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 981539001098 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 981539001099 putative Zn2+ binding site [ion binding]; other site 981539001100 putative DNA binding site [nucleotide binding]; other site 981539001101 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352 981539001102 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 981539001103 dimer interface [polypeptide binding]; other site 981539001104 active site 981539001105 CoA binding pocket [chemical binding]; other site 981539001106 acyl carrier protein; Provisional; Region: acpP; PRK00982 981539001107 putative enoyl-[acyl-carrier-protein] reductase II; Region: enACPred_II; TIGR03151 981539001108 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 981539001109 FMN binding site [chemical binding]; other site 981539001110 substrate binding site [chemical binding]; other site 981539001111 putative catalytic residue [active] 981539001112 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 981539001113 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 981539001114 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 981539001115 beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333 981539001116 NAD(P) binding site [chemical binding]; other site 981539001117 homotetramer interface [polypeptide binding]; other site 981539001118 homodimer interface [polypeptide binding]; other site 981539001119 active site 981539001120 3-oxoacyl-(acyl carrier protein) synthase II; Reviewed; Region: PRK07314 981539001121 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 981539001122 dimer interface [polypeptide binding]; other site 981539001123 active site 981539001124 acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated; Region: PRK06302 981539001125 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 981539001126 carboxyltransferase (CT) interaction site; other site 981539001127 biotinylation site [posttranslational modification]; other site 981539001128 FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288 981539001129 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591 981539001130 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 981539001131 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 981539001132 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 981539001133 acetyl-CoA carboxylase subunit beta; Validated; Region: PRK05654 981539001134 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 981539001135 acetyl-CoA carboxylase subunit alpha; Provisional; Region: PRK12319 981539001136 seryl-tRNA synthetase; Provisional; Region: PRK05431 981539001137 Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403 981539001138 Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770 981539001139 dimer interface [polypeptide binding]; other site 981539001140 active site 981539001141 motif 1; other site 981539001142 motif 2; other site 981539001143 motif 3; other site 981539001144 Domain of unknown function (DUF956); Region: DUF956; pfam06115 981539001145 Phosphotransferase system, mannose/fructose/N-acetylgalactosamine-specific component IID [Carbohydrate transport and metabolism]; Region: ManZ; COG3716 981539001146 PTS system mannose-specific transporter subunit IIC; Provisional; Region: PRK15065 981539001147 PTS system mannose-specific transporter subunits IIAB; Provisional; Region: PRK15088 981539001148 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006 981539001149 active pocket/dimerization site; other site 981539001150 active site 981539001151 phosphorylation site [posttranslational modification] 981539001152 PTS_IIB, PTS system, Mannose/sorbose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_man; cd00001 981539001153 active site 981539001154 phosphorylation site [posttranslational modification] 981539001155 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 981539001156 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 981539001157 active site 981539001158 motif I; other site 981539001159 motif II; other site 981539001160 Protein of unknown function (DUF1361); Region: DUF1361; pfam07099 981539001161 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 981539001162 Predicted ATPase or kinase [General function prediction only]; Region: COG0802 981539001163 putative acetyltransferase YhhY; Provisional; Region: PRK10140 981539001164 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 981539001165 Coenzyme A binding pocket [chemical binding]; other site 981539001166 Transcriptional regulator [Transcription]; Region: LytR; COG1316 981539001167 HINT (histidine triad nucleotide-binding protein) subgroup: Members of this CD belong to the superfamily of histidine triad hydrolases that act on alpha-phosphate of ribonucleotides. This subgroup includes members from all three forms of cellular life; Region: HINT_subgroup; cd01277 981539001168 HIT family signature motif; other site 981539001169 catalytic residue [active] 981539001170 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 981539001171 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 981539001172 Walker A/P-loop; other site 981539001173 ATP binding site [chemical binding]; other site 981539001174 Q-loop/lid; other site 981539001175 ABC transporter signature motif; other site 981539001176 Walker B; other site 981539001177 D-loop; other site 981539001178 H-loop/switch region; other site 981539001179 Bacterial ABC transporter protein EcsB; Region: EcsB; pfam05975 981539001180 Thiamine kinase and related kinases [Coenzyme transport and metabolism]; Region: ycfN; COG0510 981539001181 Phosphotransferase enzyme family; Region: APH; pfam01636 981539001182 substrate binding site [chemical binding]; other site 981539001183 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 981539001184 S-adenosylmethionine binding site [chemical binding]; other site 981539001185 PAS fold; Region: PAS_4; pfam08448 981539001186 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 981539001187 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 981539001188 metal binding site [ion binding]; metal-binding site 981539001189 active site 981539001190 I-site; other site 981539001191 truncated glycosyl transferase family 2 981539001192 truncated glycosyl transferase family 2 981539001193 Glycosyltransferases, probably involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: COG1215 981539001194 CESA_CelA_like are involved in the elongation of the glucan chain of cellulose; Region: CESA_CelA_like; cd06421 981539001195 DXD motif; other site 981539001196 PilZ domain; Region: PilZ; pfam07238 981539001197 ribosome maturation protein RimP; Reviewed; Region: PRK00092 981539001198 Bacillus subtilis YxlS-like, C-terminal domain; Region: YlxS_C; cd01734 981539001199 putative oligomer interface [polypeptide binding]; other site 981539001200 putative RNA binding site [nucleotide binding]; other site 981539001201 transcription elongation factor NusA; Provisional; Region: nusA; PRK12327 981539001202 NusA N-terminal domain; Region: NusA_N; pfam08529 981539001203 S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455 981539001204 RNA binding site [nucleotide binding]; other site 981539001205 homodimer interface [polypeptide binding]; other site 981539001206 NusA-like KH domain; Region: KH_5; pfam13184 981539001207 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 981539001208 G-X-X-G motif; other site 981539001209 Ylxr homologs; group of conserved hypothetical bacterial proteins of unknown function; structure revealed putative RNA binding cleft; proteins are encoded by an operon that includes other proteins involved in transcription and/or translation; Region: YlxR; cd00279 981539001210 putative RNA binding cleft [nucleotide binding]; other site 981539001211 hypothetical protein; Provisional; Region: PRK07283 981539001212 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 981539001213 translation initiation factor IF-2; Region: IF-2; TIGR00487 981539001214 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 981539001215 Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887 981539001216 G1 box; other site 981539001217 putative GEF interaction site [polypeptide binding]; other site 981539001218 GTP/Mg2+ binding site [chemical binding]; other site 981539001219 Switch I region; other site 981539001220 G2 box; other site 981539001221 G3 box; other site 981539001222 Switch II region; other site 981539001223 G4 box; other site 981539001224 G5 box; other site 981539001225 This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702 981539001226 Translation-initiation factor 2; Region: IF-2; pfam11987 981539001227 mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692 981539001228 ribosome-binding factor A; Validated; Region: rbfA; PRK00521 981539001229 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 981539001230 Helix-turn-helix domain; Region: HTH_38; pfam13936 981539001231 HTH-like domain; Region: HTH_21; pfam13276 981539001232 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 981539001233 Integrase core domain; Region: rve; pfam00665 981539001234 Integrase core domain; Region: rve_2; pfam13333 981539001235 Predicted Rossmann fold nucleotide-binding protein [General function prediction only]; Region: COG1611 981539001236 Bacterial protein of unknown function (DUF925); Region: DUF925; pfam06042 981539001237 copper transport repressor, CopY/TcrY family; Region: CopY_TcrY; TIGR02698 981539001238 Penicillinase repressor; Region: Pencillinase_R; pfam03965 981539001239 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 981539001240 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 981539001241 metal-binding site [ion binding] 981539001242 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 981539001243 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 981539001244 motif II; other site 981539001245 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 981539001246 metal-binding site [ion binding] 981539001247 Predicted membrane protein [Function unknown]; Region: COG2860 981539001248 UPF0126 domain; Region: UPF0126; pfam03458 981539001249 UPF0126 domain; Region: UPF0126; pfam03458 981539001250 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 981539001251 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 981539001252 active site 981539001253 motif I; other site 981539001254 motif II; other site 981539001255 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 981539001256 Protein of unknown function (DUF2974); Region: DUF2974; pfam11187 981539001257 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 981539001258 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 981539001259 Uncharacterized protein conserved in bacteria [Function unknown]; Region: DegV; COG1307 981539001260 Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645 981539001261 Bacterial inner membrane protein; Region: Imp-YgjV; pfam10688 981539001262 Na+/phosphate symporter [Inorganic ion transport and metabolism]; Region: NptA; COG1283 981539001263 Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690 981539001264 Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690 981539001265 PhoU domain; Region: PhoU; pfam01895 981539001266 N-acetylglucosamine-6-phosphate deacetylase [Carbohydrate transport and metabolism]; Region: NagA; COG1820 981539001267 N-acetylglucosamine-6-phosphate deacetylase, NagA, catalyzes the hydrolysis of the N-acetyl group of N-acetyl-glucosamine-6-phosphate (GlcNAc-6-P) to glucosamine 6-phosphate and acetate. This is the first committed step in the biosynthetic pathway to...; Region: NagA; cd00854 981539001268 active site 981539001269 dimer interface [polypeptide binding]; other site 981539001270 Class II Glycyl-tRNA synthetase (GlyRS) alpha subunit core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes and in arabidopsis. It is responsible for the...; Region: GlyRS_alpha_core; cd00733 981539001271 dimer interface [polypeptide binding]; other site 981539001272 motif 1; other site 981539001273 active site 981539001274 motif 2; other site 981539001275 motif 3; other site 981539001276 glycyl-tRNA synthetase subunit beta; Validated; Region: glyS; PRK01233 981539001277 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 981539001278 hypothetical protein; Provisional; Region: PRK02539 981539001279 HTH domain; Region: HTH_11; pfam08279 981539001280 Transcriptional antiterminator [Transcription]; Region: BglG; COG3711 981539001281 Mga helix-turn-helix domain; Region: Mga; pfam05043 981539001282 PRD domain; Region: PRD; pfam00874 981539001283 PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568 981539001284 active site 981539001285 P-loop; other site 981539001286 phosphorylation site [posttranslational modification] 981539001287 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cl00163 981539001288 active site 981539001289 phosphorylation site [posttranslational modification] 981539001290 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 981539001291 active site 981539001292 phosphorylation site [posttranslational modification] 981539001293 truncated PTS system, EIIB component 981539001294 truncated PTS system, EIIB component 981539001295 Phosphotransferase system, fructose-specific IIC component [Carbohydrate transport and metabolism]; Region: FruA; COG1299 981539001296 Phosphotransferase system, EIIC; Region: PTS_EIIC; pfam02378 981539001297 Pentose-5-phosphate-3-epimerase [Carbohydrate transport and metabolism]; Region: Rpe; COG0036 981539001298 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 981539001299 substrate binding site [chemical binding]; other site 981539001300 hexamer interface [polypeptide binding]; other site 981539001301 metal binding site [ion binding]; metal-binding site 981539001302 Transaldolase-like fructose-6-phosphate aldolases (FSA) found in bacteria and archaea; Region: Transaldolase_FSA; cd00956 981539001303 active site 981539001304 intersubunit interactions; other site 981539001305 catalytic residue [active] 981539001306 Transketolase [Carbohydrate transport and metabolism]; Region: TktA; COG0021 981539001307 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 981539001308 TPP-binding site [chemical binding]; other site 981539001309 dimer interface [polypeptide binding]; other site 981539001310 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 981539001311 PYR/PP interface [polypeptide binding]; other site 981539001312 dimer interface [polypeptide binding]; other site 981539001313 TPP binding site [chemical binding]; other site 981539001314 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 981539001315 Enterocin A Immunity; Region: EntA_Immun; pfam08951 981539001316 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 981539001317 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 981539001318 Walker A/P-loop; other site 981539001319 ATP binding site [chemical binding]; other site 981539001320 Q-loop/lid; other site 981539001321 ABC transporter signature motif; other site 981539001322 Walker B; other site 981539001323 D-loop; other site 981539001324 H-loop/switch region; other site 981539001325 PTS system, beta-glucoside-specific IIABC component; Region: PTS-II-ABC-beta; TIGR01995 981539001326 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 981539001327 active site turn [active] 981539001328 phosphorylation site [posttranslational modification] 981539001329 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 981539001330 Phosphotransferase system IIA components [Carbohydrate transport and metabolism]; Region: NagE; COG2190 981539001331 HPr interaction site; other site 981539001332 glycerol kinase (GK) interaction site [polypeptide binding]; other site 981539001333 active site 981539001334 phosphorylation site [posttranslational modification] 981539001335 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 981539001336 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 981539001337 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 981539001338 putative active site [active] 981539001339 Glycosyl hydrolase family 1; Region: Glyco_hydro_1; cl01046 981539001340 beta-galactosidase; Region: BGL; TIGR03356 981539001341 Glutamate 5-kinase [Amino acid transport and metabolism]; Region: ProB; COG0263 981539001342 AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242 981539001343 nucleotide binding site [chemical binding]; other site 981539001344 homotetrameric interface [polypeptide binding]; other site 981539001345 putative phosphate binding site [ion binding]; other site 981539001346 putative allosteric binding site; other site 981539001347 Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079 981539001348 gamma-glutamyl phosphate reductase; Region: proA; TIGR00407 981539001349 putative catalytic cysteine [active] 981539001350 Predicted S-adenosylmethionine-dependent methyltransferase involved in cell envelope biogenesis [Cell envelope biogenesis, outer membrane]; Region: COG0275 981539001351 MraW methylase family; Region: Methyltransf_5; pfam01795 981539001352 Protein required for the initiation of cell division [Cell division and chromosome partitioning]; Region: FtsL; COG4839 981539001353 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 981539001354 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 981539001355 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 981539001356 PASTA domain. This domain is found at the C-termini of several Penicillin-binding proteins (PBPs) and bacterial serine/threonine kinases. It is a small globular fold consisting of 3 beta-sheets and an alpha-helix. The name PASTA is derived from PBP and...; Region: PASTA; cl02768 981539001357 PASTA domain of PBP2x-like proteins, second repeat. Penicillin-binding proteins (PBPs) are the major targets for beta-lactam antibiotics, like penicillins and cephalosporins. Beta-lactam antibiotics specifically inhibit transpeptidase activity by...; Region: PASTA_Pbp2x-like_2; cd06575 981539001358 phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108 981539001359 Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852 981539001360 Mg++ binding site [ion binding]; other site 981539001361 putative catalytic motif [active] 981539001362 putative substrate binding site [chemical binding]; other site 981539001363 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 981539001364 DEAD-like helicases superfamily; Region: DEXDc; smart00487 981539001365 ATP binding site [chemical binding]; other site 981539001366 Mg++ binding site [ion binding]; other site 981539001367 motif III; other site 981539001368 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 981539001369 nucleotide binding region [chemical binding]; other site 981539001370 ATP-binding site [chemical binding]; other site 981539001371 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 981539001372 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 981539001373 substrate binding pocket [chemical binding]; other site 981539001374 membrane-bound complex binding site; other site 981539001375 hinge residues; other site 981539001376 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 981539001377 dimer interface [polypeptide binding]; other site 981539001378 conserved gate region; other site 981539001379 putative PBP binding loops; other site 981539001380 ABC-ATPase subunit interface; other site 981539001381 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 981539001382 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 981539001383 Walker A/P-loop; other site 981539001384 ATP binding site [chemical binding]; other site 981539001385 Q-loop/lid; other site 981539001386 ABC transporter signature motif; other site 981539001387 Walker B; other site 981539001388 D-loop; other site 981539001389 H-loop/switch region; other site 981539001390 Protein of unknown function (DUF4059); Region: DUF4059; pfam13268 981539001391 thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292 981539001392 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 981539001393 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 981539001394 nicotinate phosphoribosyltransferase; Validated; Region: PRK09243 981539001395 Nicotinate phosphoribosyltransferase (NAPRTase), subgroup A. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting, reaction...; Region: NAPRTase_A; cd01570 981539001396 active site 981539001397 NAD synthase [Coenzyme metabolism]; Region: NadE; COG0171 981539001398 NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553 981539001399 homodimer interface [polypeptide binding]; other site 981539001400 NAD binding pocket [chemical binding]; other site 981539001401 ATP binding pocket [chemical binding]; other site 981539001402 Mg binding site [ion binding]; other site 981539001403 active-site loop [active] 981539001404 Peptidase C1B subfamily (MEROPS database nomenclature); composed of eukaryotic bleomycin hydrolases (BH) and bacterial aminopeptidases C (pepC). The proteins of this subfamily contain a large insert relative to the C1A peptidase (papain) subfamily. BH is...; Region: Peptidase_C1B; cd00585 981539001405 trimer interface [polypeptide binding]; other site 981539001406 active site 981539001407 G bulge; other site 981539001408 Transglycosylase; Region: Transgly; pfam00912 981539001409 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 981539001410 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 981539001411 Holliday junction-specific endonuclease; Reviewed; Region: recU; PRK02234 981539001412 hypothetical protein; Provisional; Region: PRK13660 981539001413 cell division protein GpsB; Provisional; Region: PRK14127 981539001414 DivIVA domain; Region: DivI1A_domain; TIGR03544 981539001415 Predicted N6-adenine-specific DNA methylase [DNA replication, recombination, and repair]; Region: COG0116 981539001416 THUMP domain associated with S-adenosylmethionine-dependent methyltransferases; Region: THUMP_AdoMetMT; cd11715 981539001417 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 981539001418 acetoin reductase; Validated; Region: PRK08643 981539001419 meso-2,3-butanediol dehydrogenase-like, classical (c) SDRs; Region: meso-BDH-like_SDR_c; cd05366 981539001420 NAD binding site [chemical binding]; other site 981539001421 homotetramer interface [polypeptide binding]; other site 981539001422 homodimer interface [polypeptide binding]; other site 981539001423 active site 981539001424 substrate binding site [chemical binding]; other site 981539001425 S-ribosylhomocysteinase; Provisional; Region: PRK02260 981539001426 hypothetical protein; Provisional; Region: PRK00106 981539001427 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 981539001428 Zn2+ binding site [ion binding]; other site 981539001429 Mg2+ binding site [ion binding]; other site 981539001430 Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194 981539001431 Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071 981539001432 catalytic site [active] 981539001433 G-X2-G-X-G-K; other site 981539001434 DNA-directed RNA polymerase subunit omega; Reviewed; Region: rpoZ; PRK00392 981539001435 Primosomal protein N' (replication factor Y) - superfamily II helicase [DNA replication, recombination, and repair]; Region: PriA; COG1198 981539001436 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 981539001437 ATP binding site [chemical binding]; other site 981539001438 putative Mg++ binding site [ion binding]; other site 981539001439 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 981539001440 ATP-binding site [chemical binding]; other site 981539001441 methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005 981539001442 Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646 981539001443 putative active site [active] 981539001444 substrate binding site [chemical binding]; other site 981539001445 putative cosubstrate binding site; other site 981539001446 catalytic site [active] 981539001447 C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704 981539001448 substrate binding site [chemical binding]; other site 981539001449 16S rRNA methyltransferase B; Provisional; Region: PRK14902 981539001450 NusB family; Region: NusB; pfam01029 981539001451 putative RNA binding site [nucleotide binding]; other site 981539001452 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 981539001453 S-adenosylmethionine binding site [chemical binding]; other site 981539001454 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143 981539001455 active site 981539001456 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 981539001457 Catalytic domain of Protein Kinases; Region: PKc; cd00180 981539001458 active site 981539001459 ATP binding site [chemical binding]; other site 981539001460 substrate binding site [chemical binding]; other site 981539001461 activation loop (A-loop); other site 981539001462 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 981539001463 PASTA domain. This domain is found at the C-termini of several Penicillin-binding proteins (PBPs) and bacterial serine/threonine kinases. It is a small globular fold consisting of 3 beta-sheets and an alpha-helix. The name PASTA is derived from PBP and...; Region: PASTA; cl02768 981539001464 PASTA domain. This domain is found at the C-termini of several Penicillin-binding proteins (PBPs) and bacterial serine/threonine kinases. It is a small globular fold consisting of 3 beta-sheets and an alpha-helix. The name PASTA is derived from PBP and...; Region: PASTA; cl02768 981539001465 Predicted membrane protein [Function unknown]; Region: COG4758 981539001466 Cell wall-active antibiotics response protein (DUF2154); Region: DUF2154; pfam09922 981539001467 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 981539001468 Histidine kinase; Region: HisKA_3; pfam07730 981539001469 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 981539001470 ATP binding site [chemical binding]; other site 981539001471 Mg2+ binding site [ion binding]; other site 981539001472 G-X-G motif; other site 981539001473 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 981539001474 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 981539001475 active site 981539001476 phosphorylation site [posttranslational modification] 981539001477 intermolecular recognition site; other site 981539001478 dimerization interface [polypeptide binding]; other site 981539001479 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 981539001480 DNA binding residues [nucleotide binding] 981539001481 dimerization interface [polypeptide binding]; other site 981539001482 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 981539001483 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 981539001484 active site 981539001485 motif I; other site 981539001486 motif II; other site 981539001487 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cl17915 981539001488 active site 981539001489 motif I; other site 981539001490 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 981539001491 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317 981539001492 active site 981539001493 Predicted RNA binding protein (contains ribosomal protein S1 domain) [Translation, ribosomal structure and biogenesis]; Region: VacB; COG1098 981539001494 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cd00164 981539001495 RNA binding site [nucleotide binding]; other site 981539001496 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 981539001497 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 981539001498 dimer interface [polypeptide binding]; other site 981539001499 pyridoxal 5'-phosphate binding site [chemical binding]; other site 981539001500 catalytic residue [active] 981539001501 Uncharacterized conserved protein [Function unknown]; Region: COG1739 981539001502 Uncharacterized protein family UPF0029; Region: UPF0029; pfam01205 981539001503 Domain of unknown function (DUF1949); Region: DUF1949; pfam09186 981539001504 Superfamily II DNA/RNA helicase required for DNA uptake (late competence protein) [DNA replication, recombination, and repair]; Region: comFA; COG4098 981539001505 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 981539001506 ATP binding site [chemical binding]; other site 981539001507 putative Mg++ binding site [ion binding]; other site 981539001508 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 981539001509 nucleotide binding region [chemical binding]; other site 981539001510 ATP-binding site [chemical binding]; other site 981539001511 Predicted amidophosphoribosyltransferases [General function prediction only]; Region: ComFC; COG1040 981539001512 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 981539001513 active site 981539001514 RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552 981539001515 30S subunit binding site; other site 981539001516 Staphylococcal protein of unknown function (DUF960); Region: DUF960; pfam06124 981539001517 hypothetical protein; Provisional; Region: PRK13662 981539001518 recombination regulator RecX; Provisional; Region: recX; PRK14135 981539001519 TRAM domain; Region: TRAM; pfam01938 981539001520 SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase [Translation, ribosomal structure and biogenesis]; Region: TrmA; COG2265 981539001521 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 981539001522 S-adenosylmethionine binding site [chemical binding]; other site 981539001523 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 981539001524 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 981539001525 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 981539001526 Predicted peptidase [General function prediction only]; Region: COG4099 981539001527 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 981539001528 Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247 981539001529 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 981539001530 Coenzyme A binding pocket [chemical binding]; other site 981539001531 Nicotinamide mononucleotide transporter; Region: NMN_transporter; cl01256 981539001532 Deoxynucleoside kinases [Nucleotide transport and metabolism]; Region: COG1428 981539001533 Deoxyribonucleoside kinase (dNK) catalyzes the phosphorylation of deoxyribonucleosides to yield corresponding monophosphates (dNMPs). This family consists of various deoxynucleoside kinases including deoxyribo- cytidine (EC 2.7.1.74), guanosine (EC 2.7.1; Region: dNK; cd01673 981539001534 Substrate-binding site [chemical binding]; other site 981539001535 Substrate specificity [chemical binding]; other site 981539001536 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 981539001537 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 981539001538 Coenzyme A binding pocket [chemical binding]; other site 981539001539 Phosphorylase superfamily; Region: PNP_UDP_1; pfam01048 981539001540 Domain of unknown function (DUF1912); Region: DUF1912; pfam08930 981539001541 hypothetical protein; Provisional; Region: PRK07758 981539001542 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 981539001543 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 981539001544 AAA domain; Region: AAA_18; pfam13238 981539001545 Sulphate Transporter and Anti-Sigma factor antagonist domain found in the C-terminal region of sulphate transporters as well as in bacterial and archaeal proteins involved in the regulation of sigma factors; Region: STAS; cl00604 981539001546 valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729 981539001547 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 981539001548 active site 981539001549 HIGH motif; other site 981539001550 nucleotide binding site [chemical binding]; other site 981539001551 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 981539001552 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 981539001553 active site 981539001554 KMSKS motif; other site 981539001555 Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962 981539001556 tRNA binding surface [nucleotide binding]; other site 981539001557 anticodon binding site; other site 981539001558 Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458 981539001559 SIR2 superfamily of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+; Region: SIR2; cl00195 981539001560 Protein of unknown function (DUF419); Region: DUF419; cl15265 981539001561 H+ Antiporter protein; Region: 2A0121; TIGR00900 981539001562 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 981539001563 putative substrate translocation pore; other site 981539001564 probable dihydroxyacetone kinase regulator; Region: DHAK_reg; TIGR02366 981539001565 Transcriptional regulator C-terminal region; Region: TetR_C_8; pfam14278 981539001566 Asparagine synthetase A [Amino acid transport and metabolism]; Region: AsnA; COG2502 981539001567 motif 1; other site 981539001568 dimer interface [polypeptide binding]; other site 981539001569 active site 981539001570 motif 2; other site 981539001571 motif 3; other site 981539001572 V-type ATP synthase subunit I; Validated; Region: PRK05771 981539001573 N6-adenine-specific methylase [DNA replication, recombination, and repair]; Region: COG0742 981539001574 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 981539001575 S-adenosylmethionine binding site [chemical binding]; other site 981539001576 phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168 981539001577 Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163 981539001578 active site 981539001579 (T/H)XGH motif; other site 981539001580 Predicted secreted protein containing a PDZ domain [Signal transduction mechanisms]; Region: SdrC; COG3480 981539001581 PDZ domain, also called DHR (Dlg homologous region) or GLGF (after a conserved sequence motif). Many PDZ domains bind C-terminal polypeptides, though binding to internal (non-C-terminal) polypeptides and even to lipids has been demonstrated; Region: PDZ; cl00117 981539001582 protein binding site [polypeptide binding]; other site 981539001583 Protein of unknown function (DUF3923); Region: DUF3923; pfam13061 981539001584 Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cl00200 981539001585 amphipathic channel; other site 981539001586 Asn-Pro-Ala signature motifs; other site 981539001587 Escherichia coli UshA-like family, N-terminal metallophosphatase domain; Region: MPP_UshA_N_like; cd00845 981539001588 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 981539001589 active site 981539001590 metal binding site [ion binding]; metal-binding site 981539001591 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 981539001592 Protein of unknown function (DUF1027); Region: DUF1027; cl09961 981539001593 ribosomal RNA large subunit methyltransferase N; Provisional; Region: PRK14455 981539001594 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 981539001595 FeS/SAM binding site; other site 981539001596 VanZ like family; Region: VanZ; pfam04892 981539001597 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 981539001598 putative multidrug transporter membrane\ATP-binding components; Provisional; Region: PRK10789 981539001599 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 981539001600 Walker A/P-loop; other site 981539001601 ATP binding site [chemical binding]; other site 981539001602 Q-loop/lid; other site 981539001603 ABC transporter signature motif; other site 981539001604 Walker B; other site 981539001605 D-loop; other site 981539001606 H-loop/switch region; other site 981539001607 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 981539001608 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 981539001609 ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254 981539001610 Walker A/P-loop; other site 981539001611 ATP binding site [chemical binding]; other site 981539001612 Q-loop/lid; other site 981539001613 ABC transporter signature motif; other site 981539001614 Walker B; other site 981539001615 D-loop; other site 981539001616 H-loop/switch region; other site 981539001617 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 981539001618 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 981539001619 Walker A/P-loop; other site 981539001620 ATP binding site [chemical binding]; other site 981539001621 Q-loop/lid; other site 981539001622 ABC transporter signature motif; other site 981539001623 Walker B; other site 981539001624 D-loop; other site 981539001625 H-loop/switch region; other site 981539001626 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 981539001627 Histidine kinase; Region: HisKA_3; pfam07730 981539001628 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 981539001629 ATP binding site [chemical binding]; other site 981539001630 Mg2+ binding site [ion binding]; other site 981539001631 G-X-G motif; other site 981539001632 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 981539001633 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 981539001634 active site 981539001635 phosphorylation site [posttranslational modification] 981539001636 intermolecular recognition site; other site 981539001637 dimerization interface [polypeptide binding]; other site 981539001638 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 981539001639 DNA binding residues [nucleotide binding] 981539001640 dimerization interface [polypeptide binding]; other site 981539001641 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4842 981539001642 WXG100 protein secretion system (Wss), protein EssA; Region: EssA; cl11266 981539001643 WXG100 protein secretion system (Wss), protein YukC; Region: YukC; cl01868 981539001644 type VII secretion protein EssC, C-terminal domain; Region: T7_EssCb_Firm; TIGR03928 981539001645 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 981539001646 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 981539001647 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061 981539001648 V-type ATP synthase subunit I; Validated; Region: PRK05771 981539001649 Domain of unknown function (DUF4176); Region: DUF4176; cl01867 981539001650 LXG domain of WXG superfamily; Region: LXG; pfam04740 981539001651 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 981539001652 CAAX protease self-immunity; Region: Abi; pfam02517 981539001653 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 981539001654 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 981539001655 Transcriptional regulator C-terminal region; Region: TetR_C_8; pfam14278 981539001656 Cna protein B-type domain; Region: Cna_B; pfam05738 981539001657 Repeat unit of collagen-binding protein domain B; Region: CollagenBindB; cd00222 981539001658 domain interaction interfaces [polypeptide binding]; other site 981539001659 Repeat unit of collagen-binding protein domain B; Region: CollagenBindB; cd00222 981539001660 domain interaction interfaces [polypeptide binding]; other site 981539001661 Repeat unit of collagen-binding protein domain B; Region: CollagenBindB; cd00222 981539001662 domain interaction interfaces [polypeptide binding]; other site 981539001663 Repeat unit of collagen-binding protein domain B; Region: CollagenBindB; cd00222 981539001664 domain interaction interfaces [polypeptide binding]; other site 981539001665 Repeat unit of collagen-binding protein domain B; Region: CollagenBindB; cd00222 981539001666 domain interaction interfaces [polypeptide binding]; other site 981539001667 Repeat unit of collagen-binding protein domain B; Region: CollagenBindB; cd00222 981539001668 domain interaction interfaces [polypeptide binding]; other site 981539001669 Protein of unknown function (DUF2089); Region: DUF2089; pfam09862 981539001670 TraX protein; Region: TraX; cl05434 981539001671 Predicted membrane protein [Function unknown]; Region: COG3371 981539001672 Chorismate mutase type II; Region: CM_2; smart00830 981539001673 anthranilate synthase component I; Provisional; Region: PRK13570 981539001674 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 981539001675 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 981539001676 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 981539001677 Glutamine amidotransferase class-I; Region: GATase; pfam00117 981539001678 glutamine binding [chemical binding]; other site 981539001679 catalytic triad [active] 981539001680 anthranilate phosphoribosyltransferase; Provisional; Region: trpD; PRK00188 981539001681 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 981539001682 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 981539001683 Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331 981539001684 active site 981539001685 ribulose/triose binding site [chemical binding]; other site 981539001686 phosphate binding site [ion binding]; other site 981539001687 substrate (anthranilate) binding pocket [chemical binding]; other site 981539001688 product (indole) binding pocket [chemical binding]; other site 981539001689 Phosphoribosylanthranilate isomerase (PRAI) catalyzes the fourth step of the tryptophan biosynthesis, the conversion of N-(5'- phosphoribosyl)-anthranilate (PRA) to 1-(o-carboxyphenylamino)- 1-deoxyribulose 5-phosphate (CdRP). Most PRAIs are...; Region: PRAI; cd00405 981539001690 active site 981539001691 tryptophan synthase, beta subunit; Region: trpB; TIGR00263 981539001692 Tryptophan synthase-beta: Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446 981539001693 pyridoxal 5'-phosphate binding site [chemical binding]; other site 981539001694 catalytic residue [active] 981539001695 Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724 981539001696 tryptophan synthase alpha subunit; Provisional; Region: trpA; CHL00200 981539001697 substrate binding site [chemical binding]; other site 981539001698 active site 981539001699 catalytic residues [active] 981539001700 heterodimer interface [polypeptide binding]; other site 981539001701 manganese transport protein MntH; Reviewed; Region: PRK00701 981539001702 Natural resistance-associated macrophage protein; Region: Nramp; pfam01566 981539001703 truncated leader peptidase (prepilin peptidase) / N-methyltransferase 981539001704 truncated leader peptidase (prepilin peptidase) / N-methyltransferase 981539001705 DNA-binding ferritin-like protein (oxidative damage protectant) [Inorganic ion transport and metabolism]; Region: Dps; COG0783 981539001706 DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043 981539001707 dimerization interface [polypeptide binding]; other site 981539001708 DPS ferroxidase diiron center [ion binding]; other site 981539001709 ion pore; other site 981539001710 Bacterial protein of unknown function (DUF910); Region: DUF910; pfam06014 981539001711 ROK family protein (putative glucokinase); Region: ROK_glcA_fam; TIGR00744 981539001712 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 981539001713 nucleotide binding site [chemical binding]; other site 981539001714 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 981539001715 active site residue [active] 981539001716 truncated alpha-galactosidase 981539001717 truncated alpha-galactosidase 981539001718 Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455 981539001719 cellobiose phosphotransferase system IIC component; Reviewed; Region: celD; PRK09592 981539001720 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 981539001721 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 981539001722 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 981539001723 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 981539001724 Predicted membrane GTPase involved in stress response [Signal transduction mechanisms]; Region: TypA; COG1217 981539001725 Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891 981539001726 G1 box; other site 981539001727 putative GEF interaction site [polypeptide binding]; other site 981539001728 GTP/Mg2+ binding site [chemical binding]; other site 981539001729 Switch I region; other site 981539001730 G2 box; other site 981539001731 G3 box; other site 981539001732 Switch II region; other site 981539001733 G4 box; other site 981539001734 G5 box; other site 981539001735 BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu. BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691 981539001736 BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants. BipA is a highly...; Region: BipA_TypA_C; cd03710 981539001737 Protein of unknown function (DUF3165); Region: DUF3165; pfam11364 981539001738 UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK02472 981539001739 Alanine dehydrogenase/PNT, C-terminal domain; Region: AlaDh_PNT_C; smart01002 981539001740 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 981539001741 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 981539001742 undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726 981539001743 MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785 981539001744 homodimer interface [polypeptide binding]; other site 981539001745 active site 981539001746 POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478 981539001747 Cell division protein FtsQ; Region: FtsQ; pfam03799 981539001748 Cell division ATPase FtsA [Cell division and chromosome partitioning]; Region: ftsA; COG0849 981539001749 Cell division protein FtsA; Region: FtsA; smart00842 981539001750 Cell division protein FtsA; Region: FtsA; pfam14450 981539001751 Domain of unknown function (DUF3484); Region: DUF3484; pfam11983 981539001752 cell division protein FtsZ; Validated; Region: PRK09330 981539001753 FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes. FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201 981539001754 nucleotide binding site [chemical binding]; other site 981539001755 SulA interaction site; other site 981539001756 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, YBL036c-like proteins; Region: PLPDE_III_YBL036c_like; cd00635 981539001757 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 981539001758 catalytic residue [active] 981539001759 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1799 981539001760 YGGT family; Region: YGGT; pfam02325 981539001761 Uncharacterized conserved protein, contains S4-like domain [Function unknown]; Region: COG2302 981539001762 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 981539001763 RNA binding surface [nucleotide binding]; other site 981539001764 DivIVA protein; Region: DivIVA; pfam05103 981539001765 DivIVA domain; Region: DivI1A_domain; TIGR03544 981539001766 isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK05743 981539001767 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 981539001768 active site 981539001769 HIGH motif; other site 981539001770 nucleotide binding site [chemical binding]; other site 981539001771 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 981539001772 active site 981539001773 KMSKS motif; other site 981539001774 Anticodon-binding domain of bacterial and eukaryotic mitochondrial isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_BEm; cd07960 981539001775 tRNA binding surface [nucleotide binding]; other site 981539001776 anticodon binding site; other site 981539001777 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 981539001778 Domain of unknown function (DUF1827); Region: DUF1827; pfam08860 981539001779 Contains a crystal structure of the Nudix hydrolase from Enterococcus faecalis, which has an unknown function. In general, members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes...; Region: Nudix_Hydrolase_25; cd04684 981539001780 nudix motif; other site 981539001781 ATP-binding subunits of Clp protease and DnaK/DnaJ chaperones [Posttranslational modification, protein turnover, chaperones]; Region: clpA; COG0542 981539001782 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 981539001783 Walker A motif; other site 981539001784 ATP binding site [chemical binding]; other site 981539001785 Walker B motif; other site 981539001786 arginine finger; other site 981539001787 UvrB/uvrC motif; Region: UVR; pfam02151 981539001788 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 981539001789 Walker A motif; other site 981539001790 ATP binding site [chemical binding]; other site 981539001791 Walker B motif; other site 981539001792 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 981539001793 Protein of unknown function (DUF3278); Region: DUF3278; pfam11683 981539001794 ornithine carbamoyltransferase; Validated; Region: PRK02102 981539001795 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 981539001796 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 981539001797 Protein of unknown function (DUF1797); Region: DUF1797; cl11550 981539001798 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 981539001799 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 981539001800 dimer interface [polypeptide binding]; other site 981539001801 conserved gate region; other site 981539001802 putative PBP binding loops; other site 981539001803 ABC-ATPase subunit interface; other site 981539001804 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 981539001805 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 981539001806 Walker A/P-loop; other site 981539001807 ATP binding site [chemical binding]; other site 981539001808 Q-loop/lid; other site 981539001809 ABC transporter signature motif; other site 981539001810 Walker B; other site 981539001811 D-loop; other site 981539001812 H-loop/switch region; other site 981539001813 This entry represents the core domain of the ferrous iron (Fe2+) transport protein FeoA found in bacteria; Region: FeoA; smart00899 981539001814 Fe2+ transport system protein A [Inorganic ion transport and metabolism]; Region: FeoA; COG1918 981539001815 Fe2+ transport system protein B [Inorganic ion transport and metabolism]; Region: FeoB; COG0370 981539001816 Ferrous iron transport protein B (FeoB) family; Region: FeoB; cd01879 981539001817 G1 box; other site 981539001818 GTP/Mg2+ binding site [chemical binding]; other site 981539001819 Switch I region; other site 981539001820 G2 box; other site 981539001821 G3 box; other site 981539001822 Switch II region; other site 981539001823 G4 box; other site 981539001824 G5 box; other site 981539001825 Nucleoside recognition; Region: Gate; pfam07670 981539001826 Ferrous iron transport protein B C terminus; Region: FeoB_C; pfam07664 981539001827 Nucleoside recognition; Region: Gate; pfam07670 981539001828 bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK14179 981539001829 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763 981539001830 NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080 981539001831 homodimer interface [polypeptide binding]; other site 981539001832 NADP binding site [chemical binding]; other site 981539001833 substrate binding site [chemical binding]; other site 981539001834 B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171 981539001835 putative substrate binding site [chemical binding]; other site 981539001836 putative ATP binding site [chemical binding]; other site 981539001837 Response regulator receiver domain; Region: Response_reg; pfam00072 981539001838 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 981539001839 active site 981539001840 phosphorylation site [posttranslational modification] 981539001841 intermolecular recognition site; other site 981539001842 dimerization interface [polypeptide binding]; other site 981539001843 LytTr DNA-binding domain; Region: LytTR; pfam04397 981539001844 Predicted signal transduction protein with a C-terminal ATPase domain [Signal transduction mechanisms]; Region: COG2972 981539001845 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 981539001846 Surface antigen [General function prediction only]; Region: COG3942 981539001847 CHAP domain; Region: CHAP; cl17642 981539001848 GBS Bsp-like repeat; Region: GBS_Bsp-like; pfam08481 981539001849 GBS Bsp-like repeat; Region: GBS_Bsp-like; pfam08481 981539001850 GBS Bsp-like repeat; Region: GBS_Bsp-like; pfam08481 981539001851 GBS Bsp-like repeat; Region: GBS_Bsp-like; pfam08481 981539001852 Bacterial SH3 domain; Region: SH3_5; pfam08460 981539001853 Gram-positive signal peptide, YSIRK family; Region: YSIRK_signal; TIGR01168 981539001854 Bacterial SH3 domain; Region: SH3_5; pfam08460 981539001855 GBS Bsp-like repeat; Region: GBS_Bsp-like; pfam08481 981539001856 Bacterial SH3 domain; Region: SH3_5; pfam08460 981539001857 GBS Bsp-like repeat; Region: GBS_Bsp-like; pfam08481 981539001858 GBS Bsp-like repeat; Region: GBS_Bsp-like; pfam08481 981539001859 GBS Bsp-like repeat; Region: GBS_Bsp-like; pfam08481 981539001860 GBS Bsp-like repeat; Region: GBS_Bsp-like; pfam08481 981539001861 GBS Bsp-like repeat; Region: GBS_Bsp-like; pfam08481 981539001862 Bacterial SH3 domain; Region: SH3_5; pfam08460 981539001863 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 981539001864 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 981539001865 exodeoxyribonuclease VII large subunit; Reviewed; Region: xseA; PRK00286 981539001866 ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489 981539001867 generic binding surface II; other site 981539001868 generic binding surface I; other site 981539001869 exodeoxyribonuclease VII small subunit; Provisional; Region: PRK00977 981539001870 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 981539001871 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 981539001872 substrate binding pocket [chemical binding]; other site 981539001873 chain length determination region; other site 981539001874 substrate-Mg2+ binding site; other site 981539001875 catalytic residues [active] 981539001876 aspartate-rich region 1; other site 981539001877 active site lid residues [active] 981539001878 aspartate-rich region 2; other site 981539001879 Predicted rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: COG1189 981539001880 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 981539001881 RNA binding surface [nucleotide binding]; other site 981539001882 FtsJ-like methyltransferase; Region: FtsJ; pfam01728 981539001883 Arginine repressor [Transcription]; Region: ArgR; COG1438 981539001884 Arginine repressor, DNA binding domain; Region: Arg_repressor; pfam01316 981539001885 Arginine repressor, C-terminal domain; Region: Arg_repressor_C; pfam02863 981539001886 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: RecN; COG0497 981539001887 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 981539001888 Walker A/P-loop; other site 981539001889 ATP binding site [chemical binding]; other site 981539001890 Q-loop/lid; other site 981539001891 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 981539001892 ABC transporter signature motif; other site 981539001893 Walker B; other site 981539001894 D-loop; other site 981539001895 H-loop/switch region; other site 981539001896 EDD domain protein, DegV family; Region: DegV; TIGR00762 981539001897 Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645 981539001898 Members of the SGNH-hydrolase superfamily, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase_YpmR_like; cd04506 981539001899 active site 981539001900 catalytic triad [active] 981539001901 oxyanion hole [active] 981539001902 Uncharacterized protein conserved in bacteria (DUF2140); Region: DUF2140; pfam09911 981539001903 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 981539001904 IHF dimer interface [polypeptide binding]; other site 981539001905 IHF - DNA interface [nucleotide binding]; other site 981539001906 amino acid/peptide transporter (Peptide:H+ symporter), bacterial; Region: yjdL_sub1_fam; TIGR00924 981539001907 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 981539001908 POT family; Region: PTR2; pfam00854 981539001909 dihydroorotate dehydrogenase (subfamily 1) family protein; Region: pyrD_sub1_fam; TIGR01037 981539001910 Dihydroorotate dehydrogenase (DHOD) class 1A FMN-binding domain. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine...; Region: DHOD_1A_like; cd04741 981539001911 active site 981539001912 FMN binding site [chemical binding]; other site 981539001913 substrate binding site [chemical binding]; other site 981539001914 catalytic residues [active] 981539001915 homodimer interface [polypeptide binding]; other site 981539001916 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 981539001917 Medium chain dehydrogenases/reductase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR5; cd08271 981539001918 putative NAD(P) binding site [chemical binding]; other site 981539001919 substrate binding site [chemical binding]; other site 981539001920 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 981539001921 dimerization interface [polypeptide binding]; other site 981539001922 putative DNA binding site [nucleotide binding]; other site 981539001923 putative Zn2+ binding site [ion binding]; other site 981539001924 heavy metal-(Cd/Co/Hg/Pb/Zn)-translocating P-type ATPase; Region: ATPase-IB2_Cd; TIGR01512 981539001925 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 981539001926 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 981539001927 motif I; other site 981539001928 motif II; other site 981539001929 Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism]; Region: EmrE; COG2076 981539001930 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 981539001931 catalytic core [active] 981539001932 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 981539001933 Cytotoxic translational repressor of toxin-antitoxin stability system [Translation, ribosomal structure and biogenesis / Cell division and chromosome partitioning]; Region: RelE; COG2026 981539001934 Protein of unknown function (DUF3267); Region: DUF3267; pfam11667 981539001935 Predicted small molecule binding protein (contains 3H domain) [General function prediction only]; Region: COG1827 981539001936 HTH domain; Region: HTH_11; pfam08279 981539001937 3H domain; Region: 3H; pfam02829 981539001938 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 981539001939 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 981539001940 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 981539001941 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 981539001942 recombination protein RecR; Reviewed; Region: recR; PRK00076 981539001943 RecR protein; Region: RecR; pfam02132 981539001944 TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR. RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025 981539001945 putative active site [active] 981539001946 putative metal-binding site [ion binding]; other site 981539001947 tetramer interface [polypeptide binding]; other site 981539001948 D-alanyl-alanine synthetase A; Reviewed; Region: ddl; PRK01966 981539001949 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 981539001950 D-ala D-ala ligase C-terminus; Region: Dala_Dala_lig_C; pfam07478 981539001951 ECF-type riboflavin transporter, S component; Region: ECF-ribofla_trS; cl17272 981539001952 UDP-N-acetylmuramyl pentapeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurF; COG0770 981539001953 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 981539001954 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 981539001955 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 981539001956 O-Antigen ligase; Region: Wzy_C; cl04850 981539001957 peptide chain release factor 3; Provisional; Region: prfC; PRK00741 981539001958 Release Factor 3 (RF3) protein involved in the terminal step of translocation in bacteria; Region: RF3; cd04169 981539001959 G1 box; other site 981539001960 putative GEF interaction site [polypeptide binding]; other site 981539001961 GTP/Mg2+ binding site [chemical binding]; other site 981539001962 Switch I region; other site 981539001963 G2 box; other site 981539001964 G3 box; other site 981539001965 Switch II region; other site 981539001966 G4 box; other site 981539001967 G5 box; other site 981539001968 RF3_II: this subfamily represents the domain II of bacterial Release Factor 3 (RF3). Termination of protein synthesis by the ribosome requires two release factor (RF) classes. The class II RF3 is a GTPase that removes class I RFs (RF1 or RF2) from the...; Region: RF3_II; cd03689 981539001969 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 981539001970 DEAD-like helicases superfamily; Region: DEXDc; smart00487 981539001971 ATP binding site [chemical binding]; other site 981539001972 Mg++ binding site [ion binding]; other site 981539001973 motif III; other site 981539001974 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 981539001975 nucleotide binding region [chemical binding]; other site 981539001976 ATP-binding site [chemical binding]; other site 981539001977 The GIY-YIG domain of uncharacterized protein family UPF0213 related to structure-specific endonuclease SLX1; Region: GIY-YIG_UPF0213; cd10456 981539001978 GIY-YIG motif/motif A; other site 981539001979 putative active site [active] 981539001980 putative metal binding site [ion binding]; other site 981539001981 Predicted O-methyltransferase [General function prediction only]; Region: COG4123 981539001982 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 981539001983 S-adenosylmethionine binding site [chemical binding]; other site 981539001984 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 981539001985 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 981539001986 putative acyl-acceptor binding pocket; other site 981539001987 SLBB domain; Region: SLBB; pfam10531 981539001988 comEA protein; Region: comE; TIGR01259 981539001989 Helix-hairpin-helix motif; Region: HHH; pfam00633 981539001990 Domain of unknown function (DUF4131); Region: DUF4131; pfam13567 981539001991 Predicted membrane metal-binding protein [General function prediction only]; Region: ComEC; COG0658 981539001992 Competence protein; Region: Competence; pfam03772 981539001993 Predicted hydrolase (metallo-beta-lactamase superfamily) [General function prediction only]; Region: ComEC; COG2333 981539001994 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 981539001995 YcfA-like protein; Region: YcfA; pfam07927 981539001996 Uncharacterized protein family (UPF0150); Region: UPF0150; pfam03681 981539001997 HD domain; Region: HD_3; pfam13023 981539001998 CYTH-like (also known as triphosphate tunnel metalloenzyme (TTM)-like) Phosphatases; Region: CYTH-like_Pase; cl11964 981539001999 DNA polymerase III subunit delta; Reviewed; Region: holA; PRK05574 981539002000 DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144 981539002001 Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605 981539002002 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 981539002003 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 981539002004 hypothetical protein; Validated; Region: PRK00110 981539002005 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Provisional; Region: queA; PRK00147 981539002006 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Region: queA; TIGR00113 981539002007 CCC1-related family of proteins; Region: CCC1_like; cl00278 981539002008 VIT family; Region: VIT1; pfam01988 981539002009 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363 981539002010 GlcN6P_deaminase: Glucosamine-6-phosphate (GlcN6P) deaminase subfamily; GlcN6P deaminase catalyzes the reversible conversion of GlcN6P to D-fructose-6-phosphate (Fru6P) and ammonium. The reaction is an aldo-keto isomerization coupled with an amination or...; Region: GlcN6P_deaminase; cd01399 981539002011 active site 981539002012 trimer interface [polypeptide binding]; other site 981539002013 allosteric site; other site 981539002014 active site lid [active] 981539002015 hexamer (dimer of trimers) interface [polypeptide binding]; other site 981539002016 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 981539002017 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 981539002018 RNA binding surface [nucleotide binding]; other site 981539002019 Pseudouridine synthase, Escherichia coli RsuA like; Region: PseudoU_synth_RsuA; cd02553 981539002020 active site 981539002021 uracil binding [chemical binding]; other site 981539002022 Competence protein CoiA-like family; Region: CoiA; pfam06054 981539002023 Oligoendopeptidase F [Amino acid transport and metabolism]; Region: COG1164 981539002024 Peptidase family M3B Oligopeptidase F (PepF); Region: M3B_PepF_3; cd09608 981539002025 active site 981539002026 Zn binding site [ion binding]; other site 981539002027 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 981539002028 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 981539002029 Coenzyme A binding pocket [chemical binding]; other site 981539002030 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 981539002031 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 981539002032 motif II; other site 981539002033 Predicted O-methyltransferase [General function prediction only]; Region: COG4122 981539002034 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 981539002035 S-adenosylmethionine binding site [chemical binding]; other site 981539002036 foldase protein PrsA; Reviewed; Region: prsA; PRK01326 981539002037 alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252 981539002038 Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673 981539002039 motif 1; other site 981539002040 active site 981539002041 motif 2; other site 981539002042 motif 3; other site 981539002043 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 981539002044 DHHA1 domain; Region: DHHA1; pfam02272 981539002045 Predicted amidohydrolase [General function prediction only]; Region: COG0388 981539002046 Uncharacterized subgroup of the nitrilase superfamily (putative class 13 nitrilases); Region: nitrilase_5; cd07583 981539002047 putative active site [active] 981539002048 catalytic triad [active] 981539002049 putative dimer interface [polypeptide binding]; other site 981539002050 transaminase; Reviewed; Region: PRK08068 981539002051 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 981539002052 pyridoxal 5'-phosphate binding site [chemical binding]; other site 981539002053 homodimer interface [polypeptide binding]; other site 981539002054 catalytic residue [active] 981539002055 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 981539002056 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 981539002057 Walker A/P-loop; other site 981539002058 ATP binding site [chemical binding]; other site 981539002059 Q-loop/lid; other site 981539002060 ABC transporter signature motif; other site 981539002061 Walker B; other site 981539002062 D-loop; other site 981539002063 H-loop/switch region; other site 981539002064 N-acetyl-gamma-glutamyl-phosphate reductase; Validated; Region: argC; PRK00436 981539002065 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 981539002066 Ornithine acetyltransferase (OAT) family; also referred to as ArgJ. OAT catalyzes the first and fifth steps in arginine biosynthesis, coupling acetylation of glutamate with deacetylation of N-acetylornithine, which allows recycling of the acetyl group in...; Region: OAT; cd02152 981539002067 heterotetramer interface [polypeptide binding]; other site 981539002068 active site pocket [active] 981539002069 cleavage site 981539002070 AAK_NAGK-like: N-Acetyl-L-glutamate kinase (NAGK)-like . Included in this CD are the Escherichia coli and Pseudomonas aeruginosa type NAGKs which catalyze the phosphorylation of N-acetyl-L-glutamate (NAG) by ATP in the second step of arginine...; Region: AAK_NAGK-like; cd04238 981539002071 nucleotide binding site [chemical binding]; other site 981539002072 N-acetyl-L-glutamate binding site [chemical binding]; other site 981539002073 acetylornithine aminotransferase; Provisional; Region: PRK04260 981539002074 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 981539002075 inhibitor-cofactor binding pocket; inhibition site 981539002076 pyridoxal 5'-phosphate binding site [chemical binding]; other site 981539002077 catalytic residue [active] 981539002078 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 981539002079 Old yellow enzyme (OYE)-related FMN binding domain, group 4. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a reducing agent with oxygens, quinones, and alpha,beta-unsaturated aldehydes and ketones, and can act as...; Region: OYE_like_4_FMN; cd04735 981539002080 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 981539002081 putative active site [active] 981539002082 putative FMN binding site [chemical binding]; other site 981539002083 putative substrate binding site [chemical binding]; other site 981539002084 putative catalytic residue [active] 981539002085 Type 1 glutamine amidotransferase (GATase1)-like domain found in proteins similar to Escherichia coli Hsp31 protein; Region: GATase1_Hsp31_like; cd03141 981539002086 Putative intracellular protease/amidase [General function prediction only]; Region: ThiJ; COG0693 981539002087 potential catalytic triad [active] 981539002088 conserved cys residue [active] 981539002089 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 981539002090 Helix-Turn-Helix DNA binding domain of the MerR-like transcription regulators YyaN and YraB; Region: HTH_YyaN; cd01109 981539002091 DNA binding residues [nucleotide binding] 981539002092 putative dimer interface [polypeptide binding]; other site 981539002093 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3238 981539002094 Protein of unknown function, DUF606; Region: DUF606; pfam04657 981539002095 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 981539002096 non-specific DNA binding site [nucleotide binding]; other site 981539002097 salt bridge; other site 981539002098 sequence-specific DNA binding site [nucleotide binding]; other site 981539002099 Protein of unknown function (DUF3169); Region: DUF3169; pfam11368 981539002100 riboflavin biosynthesis protein RibD; Region: eubact_ribD; TIGR00326 981539002101 Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284 981539002102 catalytic motif [active] 981539002103 Zn binding site [ion binding]; other site 981539002104 RibD C-terminal domain; Region: RibD_C; pfam01872 981539002105 riboflavin synthase subunit alpha; Provisional; Region: PRK09289 981539002106 Lumazine binding domain; Region: Lum_binding; pfam00677 981539002107 Lumazine binding domain; Region: Lum_binding; pfam00677 981539002108 bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II protein; Provisional; Region: PRK09311 981539002109 3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; pfam00926 981539002110 GTP cyclohydrolase II (RibA). GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641 981539002111 dimerization interface [polypeptide binding]; other site 981539002112 active site 981539002113 lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209 981539002114 homopentamer interface [polypeptide binding]; other site 981539002115 active site 981539002116 Transcriptional regulator [Transcription]; Region: LysR; COG0583 981539002117 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 981539002118 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 981539002119 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 981539002120 active site 981539002121 catalytic tetrad [active] 981539002122 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 981539002123 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 981539002124 active site 981539002125 catalytic tetrad [active] 981539002126 truncated CorA-like Mg2+ transporter protein 981539002127 truncated CorA-like Mg2+ transporter protein 981539002128 Protein of unknown function (DUF1211); Region: DUF1211; pfam06736 981539002129 Thiamine transporter protein (Thia_YuaJ); Region: Thia_YuaJ; pfam09515 981539002130 ribonucleotide-diphosphate reductase subunit beta; Provisional; Region: nrdF2; PRK13966 981539002131 Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049 981539002132 dimer interface [polypeptide binding]; other site 981539002133 putative radical transfer pathway; other site 981539002134 diiron center [ion binding]; other site 981539002135 tyrosyl radical; other site 981539002136 ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK07306 981539002137 Ribonucleotide reductase N-terminal; Region: RNR_N; pfam08343 981539002138 Class I ribonucleotide reductase; Region: RNR_I; cd01679 981539002139 active site 981539002140 dimer interface [polypeptide binding]; other site 981539002141 catalytic residues [active] 981539002142 effector binding site; other site 981539002143 R2 peptide binding site; other site 981539002144 NrdH-redoxin (NrdH) family; NrdH is a small monomeric protein with a conserved redox active CXXC motif within a TRX fold, characterized by a glutaredoxin (GRX)-like sequence and TRX-like activity profile. In vitro, it displays protein disulfide reductase...; Region: NrdH; cd02976 981539002145 catalytic residues [active] 981539002146 aconitate hydratase; Validated; Region: PRK09277 981539002147 Aconitase A catalytic domain; Region: AcnA_IRP; cd01586 981539002148 substrate binding site [chemical binding]; other site 981539002149 ligand binding site [chemical binding]; other site 981539002150 Aconitase A swivel domain. This is the major form of the TCA cycle enzyme aconitate hydratase, also known as aconitase and citrate hydro-lyase. It includes bacterial and archaeal aconitase A, and the eukaryotic cytosolic form of aconitase. This group...; Region: AcnA_IRP_Swivel; cd01580 981539002151 substrate binding site [chemical binding]; other site 981539002152 Bacillus subtilis (Bs) citrate synthase (CS)-II_like. CS catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the citric acid cycle (TCA or Krebs cycle). 2MCS catalyzes the...; Region: BSuCS-II_like; cd06110 981539002153 dimer interface [polypeptide binding]; other site 981539002154 Citrate synthase; Region: Citrate_synt; pfam00285 981539002155 active site 981539002156 citrylCoA binding site [chemical binding]; other site 981539002157 oxalacetate/citrate binding site [chemical binding]; other site 981539002158 coenzyme A binding site [chemical binding]; other site 981539002159 catalytic triad [active] 981539002160 Isocitrate/isopropylmalate dehydrogenase; Region: Iso_dh; cl00445 981539002161 isocitrate dehydrogenase; Validated; Region: PRK07362 981539002162 Predicted membrane protein [Function unknown]; Region: COG4905 981539002163 Protein of unknown function (DUF1113); Region: DUF1113; pfam06541 981539002164 The band 7 domain of flotillin (reggie) like proteins. This group contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin. Many of these band 7 domain-containing proteins are lipid raft-associated. Individual proteins of this...; Region: Band_7; cl02525 981539002165 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 981539002166 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 981539002167 active site 981539002168 motif I; other site 981539002169 motif II; other site 981539002170 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 981539002171 Transcriptional regulators [Transcription]; Region: PurR; COG1609 981539002172 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 981539002173 DNA binding site [nucleotide binding] 981539002174 domain linker motif; other site 981539002175 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 981539002176 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cl00630 981539002177 putative active site [active] 981539002178 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 981539002179 homotrimer interaction site [polypeptide binding]; other site 981539002180 putative active site [active] 981539002181 truncated 2-hydroxyglutaryl-CoA dehydratase activator 981539002182 truncated 2-hydroxyglutaryl-CoA dehydratase activator 981539002183 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 981539002184 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 981539002185 Protein of unknown function (DUF1003); Region: DUF1003; pfam06210 981539002186 Domain of unknown function (DUF4118); Region: DUF4118; pfam13493 981539002187 GAF domain; Region: GAF_3; pfam13492 981539002188 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 981539002189 Putative NodB-like catalytic domain of uncharacterized proteins found in bacteria; Region: CE4_COG4878; cd10924 981539002190 NodB motif; other site 981539002191 putative active site [active] 981539002192 putative catalytic site [active] 981539002193 putative Zn binding site [ion binding]; other site 981539002194 This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_3; cd03813 981539002195 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 981539002196 Predicted membrane protein [Function unknown]; Region: COG4267 981539002197 CotH protein; Region: CotH; pfam08757 981539002198 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 981539002199 Interdomain contacts; other site 981539002200 Cytokine receptor motif; other site 981539002201 Polyphosphate(polyP) polymerase domain of yeast vacuolar transport chaperone (VTC) proteins VTC-2, -3 and- 4, and similar proteins; Region: PolyPPase_VTC_like; cd07750 981539002202 putative metal binding residues [ion binding]; other site 981539002203 signature motif; other site 981539002204 dimer interface [polypeptide binding]; other site 981539002205 active site 981539002206 polyP binding site; other site 981539002207 substrate binding site [chemical binding]; other site 981539002208 acceptor-phosphate pocket; other site 981539002209 UDP-glucose 4-epimerase; Region: PLN02240 981539002210 UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247 981539002211 NAD binding site [chemical binding]; other site 981539002212 homodimer interface [polypeptide binding]; other site 981539002213 active site 981539002214 substrate binding site [chemical binding]; other site 981539002215 glmZ(sRNA)-inactivating NTPase; Provisional; Region: PRK05416 981539002216 conserved hypothetical protein, cofD-related; Region: CofD_related; TIGR01826 981539002217 Family of CofD-like proteins and proteins related to YvcK; Region: CofD_YvcK; cd07044 981539002218 dimer interface [polypeptide binding]; other site 981539002219 phosphate binding site [ion binding]; other site 981539002220 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1481 981539002221 Sporulation Regulator WhiA N terminal; Region: WhiA_N; pfam10298 981539002222 Peptidase family C69; Region: Peptidase_C69; pfam03577 981539002223 truncated transposase 981539002224 truncated transposase 981539002225 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 981539002226 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 981539002227 non-specific DNA binding site [nucleotide binding]; other site 981539002228 salt bridge; other site 981539002229 sequence-specific DNA binding site [nucleotide binding]; other site 981539002230 transcriptional activator, Rgg/GadR/MutR family, C-terminal domain; Region: RGG_Cterm; TIGR01716 981539002231 Metal binding protein AcdA. These proteins have been shown to function in the ABC uptake of Zn2+ and Mn2+ and in competence for genetic transformation and adhesion. The AcdA proteins belong to the TroA superfamily of helical backbone metal receptor...; Region: AdcA; cd01017 981539002232 Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297 981539002233 metal binding site [ion binding]; metal-binding site 981539002234 YodA lipocalin-like domain; Region: YodA; pfam09223 981539002235 Polyphosphate(polyP) polymerase domain of yeast vacuolar transport chaperone (VTC) proteins VTC-2, -3 and- 4, and similar proteins; Region: PolyPPase_VTC_like; cd07750 981539002236 putative metal binding residues [ion binding]; other site 981539002237 signature motif; other site 981539002238 dimer interface [polypeptide binding]; other site 981539002239 active site 981539002240 polyP binding site; other site 981539002241 substrate binding site [chemical binding]; other site 981539002242 acceptor-phosphate pocket; other site 981539002243 Mannosyl-glycoprotein endo-beta-N-acetylglucosaminidase; Region: Glucosaminidase; cl17361 981539002244 50S ribosomal protein L31 type B; Reviewed; Region: rpmE2; PRK01678 981539002245 Exopolyphosphatase-related proteins [General function prediction only]; Region: COG0618 981539002246 DHH family; Region: DHH; pfam01368 981539002247 DHHA1 domain; Region: DHHA1; pfam02272 981539002248 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 981539002249 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 981539002250 dimerization domain swap beta strand [polypeptide binding]; other site 981539002251 regulatory protein interface [polypeptide binding]; other site 981539002252 active site 981539002253 regulatory phosphorylation site [posttranslational modification]; other site 981539002254 Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism]; Region: PtsA; COG1080 981539002255 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 981539002256 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 981539002257 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 981539002258 NADP+-dependent non-phosphorylating glyceraldehyde 3-phosphate dehydrogenase and ALDH family 11; Region: ALDH_F11_NP-GAPDH; cd07082 981539002259 NADP-dependent glyceraldehyde-3-phosphate dehydrogenase; Provisional; Region: PLN00412 981539002260 tetrameric interface [polypeptide binding]; other site 981539002261 activator binding site; other site 981539002262 NADP binding site [chemical binding]; other site 981539002263 substrate binding site [chemical binding]; other site 981539002264 catalytic residues [active] 981539002265 Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and...; Region: PEPCK_HprK; cl00270 981539002266 active site 981539002267 metal-binding site [ion binding] 981539002268 active site 981539002269 nucleotide-binding site [chemical binding]; other site 981539002270 nucleotide-binding site [chemical binding]; other site 981539002271 Subtilisin-like serine proteases [Posttranslational modification, protein turnover, chaperones]; Region: AprE; COG1404 981539002272 Peptidase S8 family domain in Streptococcal C5a peptidases; Region: Peptidases_S8_C5a_Peptidase; cd07475 981539002273 putative active site [active] 981539002274 catalytic triad [active] 981539002275 PA_C5a_like: Protease-associated domain containing proteins like Streptococcus pyogenes C5a peptidase. This group contains various PA domain-containing proteins similar to S. pyogenes C5a, including, i) Vpr, a minor extracellular serine protease from...; Region: PA_C5a_like; cd02133 981539002276 PA/protease domain interface [polypeptide binding]; other site 981539002277 putative integrin binding motif; other site 981539002278 Peptidase S8 family domain in Streptococcal C5a peptidases; Region: Peptidases_S8_C5a_Peptidase; cd07475 981539002279 Fn3-like domain (DUF1034); Region: DUF1034; pfam06280 981539002280 truncated ATP-dependent RNA helicase 981539002281 truncated ATP-dependent RNA helicase 981539002282 Uridine kinase [Nucleotide transport and metabolism]; Region: Udk; COG0572 981539002283 Uridine monophosphate kinase (UMPK, EC 2.7.1.48), also known as uridine kinase or uridine-cytidine kinase (UCK), catalyzes the reversible phosphoryl transfer from ATP to uridine or cytidine to yield UMP or CMP. In the primidine nucleotide-salvage pathway; Region: UMPK; cd02023 981539002284 Sugar specificity; other site 981539002285 Pyrimidine base specificity; other site 981539002286 ATP-binding site [chemical binding]; other site 981539002287 Listeria-Bacteroides repeat domain (List_Bact_rpt); Region: Flg_new; cl09714 981539002288 carbohydrate-binding modules from Bacteroides thetaiotaomicron SusE, SusF and similar proteins; Region: CBM_SusE-F_like; cl17376 981539002289 starch binding site [chemical binding]; other site 981539002290 Transcriptional regulators [Transcription]; Region: PurR; COG1609 981539002291 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 981539002292 DNA binding site [nucleotide binding] 981539002293 domain linker motif; other site 981539002294 N-terminal Early set domain associated with the catalytic domain of cyclomaltodextrinase and pullulan-degrading enzymes; Region: E_set_CDase_PDE_N; cd02857 981539002295 homodimer interface [polypeptide binding]; other site 981539002296 Alpha amylase catalytic domain found in cyclomaltodextrinases and related proteins; Region: AmyAc_CMD; cd11338 981539002297 active site 981539002298 homodimer interface [polypeptide binding]; other site 981539002299 catalytic site [active] 981539002300 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 981539002301 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 981539002302 dimer interface [polypeptide binding]; other site 981539002303 conserved gate region; other site 981539002304 putative PBP binding loops; other site 981539002305 ABC-ATPase subunit interface; other site 981539002306 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 981539002307 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 981539002308 dimer interface [polypeptide binding]; other site 981539002309 conserved gate region; other site 981539002310 putative PBP binding loops; other site 981539002311 ABC-ATPase subunit interface; other site 981539002312 Alpha amylase catalytic domain found in maltogenic amylases, cyclodextrin glycosyltransferase, and related proteins; Region: AmyAc_AmyMalt_CGTase_like; cd11320 981539002313 Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366 981539002314 Ca binding site [ion binding]; other site 981539002315 active site 981539002316 catalytic site [active] 981539002317 Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; cl02706 981539002318 IPT domain (domain D) of cyclodextrin glycosyltransferase (CGTase) and similar enzymes. These enzymes are involved in the enzymatic hydrolysis of alpha-1,4 linkages of starch polymers and belong to the glycosyl hydrolase family 13. Most consist of three...; Region: IPT_CGTD; cd00604 981539002319 The family 20 carbohydrate-binding module (CBM20), also known as the starch-binding domain, is found in a large number of starch degrading enzymes including alpha-amylase, beta-amylase, glucoamylase, and CGTase (cyclodextrin glucanotransferase). CBM20 is...; Region: CBM20; cl15347 981539002320 starch-binding site 2 [chemical binding]; other site 981539002321 starch-binding site 1 [chemical binding]; other site 981539002322 2-isopropylmalate synthase; Validated; Region: PRK00915 981539002323 2-isopropylmalate synthase (IPMS), N-terminal catalytic TIM barrel domain; Region: DRE_TIM_IPMS; cd07940 981539002324 active site 981539002325 catalytic residues [active] 981539002326 metal binding site [ion binding]; metal-binding site 981539002327 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; pfam08502 981539002328 3-isopropylmalate dehydrogenase; Provisional; Region: PRK00772 981539002329 tartrate dehydrogenase; Region: TTC; TIGR02089 981539002330 Predicted membrane protein [Function unknown]; Region: COG3326 981539002331 3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402 981539002332 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583 981539002333 substrate binding site [chemical binding]; other site 981539002334 ligand binding site [chemical binding]; other site 981539002335 isopropylmalate isomerase small subunit; Provisional; Region: leuD; PRK01641 981539002336 Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577 981539002337 substrate binding site [chemical binding]; other site 981539002338 GAF domain-containing protein [Signal transduction mechanisms]; Region: COG1956 981539002339 GAF domain; Region: GAF_2; pfam13185 981539002340 DNA polymerase III subunits gamma and tau; Validated; Region: PRK05563 981539002341 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 981539002342 Walker A motif; other site 981539002343 ATP binding site [chemical binding]; other site 981539002344 Walker B motif; other site 981539002345 arginine finger; other site 981539002346 DNA polymerase III subunits gamma and tau domain III; Region: DNA_pol3_gamma3; pfam12169 981539002347 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 981539002348 Helix-turn-helix domain; Region: HTH_38; pfam13936 981539002349 HTH-like domain; Region: HTH_21; pfam13276 981539002350 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 981539002351 Integrase core domain; Region: rve; pfam00665 981539002352 Integrase core domain; Region: rve_2; pfam13333 981539002353 Protein of unknown function (DUF3272); Region: DUF3272; pfam11676 981539002354 bifunctional biotin--[acetyl-CoA-carboxylase] synthetase/biotin operon repressor; Provisional; Region: PRK11886 981539002355 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 981539002356 DNA-binding site [nucleotide binding]; DNA binding site 981539002357 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; pfam03099 981539002358 Biotin protein ligase C terminal domain; Region: BPL_C; pfam02237 981539002359 S-adenosylmethionine synthetase; Validated; Region: PRK05250 981539002360 S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438 981539002361 S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772 981539002362 S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773 981539002363 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 981539002364 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 981539002365 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 981539002366 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 981539002367 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 981539002368 hinge; other site 981539002369 active site 981539002370 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 981539002371 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 981539002372 Predicted transcriptional regulator containing CBS domains [Transcription]; Region: COG4109 981539002373 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 981539002374 DNA-binding site [nucleotide binding]; DNA binding site 981539002375 DRTGG domain; Region: DRTGG; pfam07085 981539002376 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 981539002377 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 981539002378 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 981539002379 active site 981539002380 Ribonuclease BN family enzyme [Replication, recombination, and repair]; Region: Rbn; COG1295 981539002381 Predicted membrane protein [Function unknown]; Region: COG2246 981539002382 GtrA-like protein; Region: GtrA; pfam04138 981539002383 Predicted membrane protein [Function unknown]; Region: COG4708 981539002384 NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956 981539002385 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114 981539002386 nucleotide binding pocket [chemical binding]; other site 981539002387 K-X-D-G motif; other site 981539002388 catalytic site [active] 981539002389 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 981539002390 NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119 981539002391 Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027 981539002392 Dimer interface [polypeptide binding]; other site 981539002393 BRCT sequence motif; other site 981539002394 putative lipid kinase; Reviewed; Region: PRK13055 981539002395 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 981539002396 Family 41 Carbohydrate-Binding Module from pullulanase-like enzymes; Region: CBM41_pullulanase; cd10315 981539002397 carbohydrate binding site [chemical binding]; other site 981539002398 pullulanase, type I; Region: pulA_typeI; TIGR02104 981539002399 Early set domain associated with the catalytic domain of pullulanase (also called dextrinase and alpha-dextrin endo-1,6-alpha glucosidase); Region: E_set_Pullulanase; cd02860 981539002400 Alpha amylase catalytic domain found in Pullulanase (also called dextrinase; alpha-dextrin endo-1,6-alpha glucosidase), limit dextrinase, and related proteins; Region: AmyAc_Pullulanase_LD-like; cd11341 981539002401 Ca binding site [ion binding]; other site 981539002402 active site 981539002403 catalytic site [active] 981539002404 glycogen branching enzyme; Provisional; Region: PRK12313 981539002405 N-terminal Early set domain associated with the catalytic domain of prokaryotic glycogen branching enzyme; Region: E_set_GBE_prok_N; cd02855 981539002406 Alpha amylase catalytic domain found in the Glycogen branching enzyme (also called 1,4-alpha-glucan branching enzyme); Region: AmyAc_Glg_BE; cd11322 981539002407 active site 981539002408 catalytic site [active] 981539002409 Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; pfam02806 981539002410 glucose-1-phosphate adenylyltransferase; Provisional; Region: glgC; PRK05293 981539002411 ADP-glucose pyrophosphorylase is involved in the biosynthesis of glycogen or starch; Region: ADP_Glucose_PP; cd02508 981539002412 ligand binding site; other site 981539002413 oligomer interface; other site 981539002414 Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651 981539002415 dimer interface [polypeptide binding]; other site 981539002416 N-terminal domain interface [polypeptide binding]; other site 981539002417 sulfate 1 binding site; other site 981539002418 truncated glucose-1-phosphate adenylyltransferase 981539002419 truncated glucose-1-phosphate adenylyltransferase 981539002420 glycogen synthase; Provisional; Region: glgA; PRK00654 981539002421 This family is most closely related to the GT1 family of glycosyltransferases. Glycogen synthase catalyzes the formation and elongation of the alpha-1,4-glucose backbone using ADP-glucose, the second and key step of glycogen biosynthesis. This family...; Region: GT1_Glycogen_synthase_DULL1_like; cd03791 981539002422 ADP-binding pocket [chemical binding]; other site 981539002423 homodimer interface [polypeptide binding]; other site 981539002424 This is a family of oligosaccharide phosphorylases. It includes yeast and mammalian glycogen phosphorylases, plant starch/glucan phosphorylase, as well as the maltodextrin phosphorylases of bacteria. The members of this family catalyze the breakdown of...; Region: GT1_Glycogen_Phosphorylase; cd04300 981539002425 homodimer interface [polypeptide binding]; other site 981539002426 glycogen/starch/alpha-glucan phosphorylases; Region: P_ylase; TIGR02093 981539002427 active site pocket [active] 981539002428 F0F1 ATP synthase subunit C; Provisional; Region: PRK13467 981539002429 F0F1-type ATP synthase, subunit a [Energy production and conversion]; Region: AtpB; COG0356 981539002430 F0F1 ATP synthase subunit A; Validated; Region: PRK05815 981539002431 F0F1-type ATP synthase, subunit b [Energy production and conversion]; Region: AtpF; COG0711 981539002432 F0F1 ATP synthase subunit B; Validated; Region: PRK05759 981539002433 F0F1 ATP synthase subunit delta; Validated; Region: PRK05758 981539002434 ATP synthase delta (OSCP) subunit; Region: OSCP; pfam00213 981539002435 F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281 981539002436 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 981539002437 F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132 981539002438 beta subunit interaction interface [polypeptide binding]; other site 981539002439 Walker A motif; other site 981539002440 ATP binding site [chemical binding]; other site 981539002441 Walker B motif; other site 981539002442 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 981539002443 mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151 981539002444 core domain interface [polypeptide binding]; other site 981539002445 delta subunit interface [polypeptide binding]; other site 981539002446 epsilon subunit interface [polypeptide binding]; other site 981539002447 F0F1 ATP synthase subunit beta; Validated; Region: PRK09280 981539002448 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 981539002449 F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133 981539002450 alpha subunit interaction interface [polypeptide binding]; other site 981539002451 Walker A motif; other site 981539002452 ATP binding site [chemical binding]; other site 981539002453 Walker B motif; other site 981539002454 inhibitor binding site; inhibition site 981539002455 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 981539002456 F0F1 ATP synthase subunit epsilon; Validated; Region: atpC; PRK00571 981539002457 mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152 981539002458 gamma subunit interface [polypeptide binding]; other site 981539002459 epsilon subunit interface [polypeptide binding]; other site 981539002460 LBP interface [polypeptide binding]; other site 981539002461 Protein of unknown function (DUF1146); Region: DUF1146; cl11486 981539002462 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 981539002463 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 981539002464 hinge; other site 981539002465 active site 981539002466 DNA-directed RNA polymerase subunit beta; Region: EpuA; pfam11772 981539002467 DNA/RNA non-specific endonuclease; Region: Endonuclease_NS; smart00892 981539002468 DNA/RNA non-specific endonuclease; Region: Endonuclease_NS; pfam01223 981539002469 phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488 981539002470 Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912 981539002471 Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496 981539002472 dimer interface [polypeptide binding]; other site 981539002473 motif 1; other site 981539002474 active site 981539002475 motif 2; other site 981539002476 motif 3; other site 981539002477 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 981539002478 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 981539002479 Coenzyme A binding pocket [chemical binding]; other site 981539002480 phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629 981539002481 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 981539002482 putative tRNA-binding site [nucleotide binding]; other site 981539002483 B3/4 domain; Region: B3_4; pfam03483 981539002484 tRNA synthetase B5 domain; Region: B5; smart00874 981539002485 Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA, PheRS is an...; Region: PheRS_beta_core; cd00769 981539002486 dimer interface [polypeptide binding]; other site 981539002487 motif 1; other site 981539002488 motif 3; other site 981539002489 motif 2; other site 981539002490 Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; smart00896 981539002491 ATP-dependent nuclease subunit B; Region: rexB_recomb; TIGR02774 981539002492 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 981539002493 helicase-exonuclease AddAB, AddA subunit, Firmicutes type; Region: addA_Gpos; TIGR02785 981539002494 Part of AAA domain; Region: AAA_19; pfam13245 981539002495 Family description; Region: UvrD_C_2; pfam13538 981539002496 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 981539002497 CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311 981539002498 substrate binding site [chemical binding]; other site 981539002499 THF binding site; other site 981539002500 zinc-binding site [ion binding]; other site 981539002501 hypothetical protein; Provisional; Region: PRK07329 981539002502 Polymerase and Histidinol Phosphatase domain; Region: PHP; cl17102 981539002503 active site 981539002504 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 981539002505 Protein of unknown function (DUF3042); Region: DUF3042; pfam11240 981539002506 tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091 981539002507 tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324 981539002508 GTP-binding protein HflX; Region: GTP_HflX; TIGR03156 981539002509 GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167 981539002510 HflX GTPase family; Region: HflX; cd01878 981539002511 G1 box; other site 981539002512 GTP/Mg2+ binding site [chemical binding]; other site 981539002513 Switch I region; other site 981539002514 G2 box; other site 981539002515 G3 box; other site 981539002516 Switch II region; other site 981539002517 G4 box; other site 981539002518 G5 box; other site 981539002519 Galactose-1-phosphate uridyl transferase, N-terminal domain; Region: GalP_UDP_transf; pfam01087 981539002520 ribonuclease Z; Region: RNase_Z; TIGR02651 981539002521 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 981539002522 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 981539002523 NAD(P) binding site [chemical binding]; other site 981539002524 active site 981539002525 single-stranded-DNA-specific exonuclease RecJ; Region: recJ; TIGR00644 981539002526 DHH family; Region: DHH; pfam01368 981539002527 Single-strand DNA-specific exonuclease, C terminal domain; Region: ssDNA-exonuc_C; pfam10141 981539002528 Domain of unknown function (DUF4352); Region: DUF4352; pfam11611 981539002529 CAAX protease self-immunity; Region: Abi; pfam02517 981539002530 Linear amide C-N hydrolases, choloylglycine hydrolase family; Region: CBAH; pfam02275 981539002531 Penicillin V acylase (PVA), also known as conjugated bile salt acid hydrolase (CBAH), catalyzes the hydrolysis of penicillin V to yield 6-amino penicillanic acid (6-APA), an important key intermediate of semisynthetic penicillins. PVA has an N-terminal...; Region: Ntn_PVA; cd00542 981539002532 active site 981539002533 DinB superfamily; Region: DinB_2; pfam12867 981539002534 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 981539002535 ATP-binding cassette domain of the lipid transporters, subfamily A; Region: ABC_subfamily_A; cd03263 981539002536 Walker A/P-loop; other site 981539002537 ATP binding site [chemical binding]; other site 981539002538 Q-loop/lid; other site 981539002539 ABC transporter signature motif; other site 981539002540 Walker B; other site 981539002541 D-loop; other site 981539002542 H-loop/switch region; other site 981539002543 ABC-type Na+ efflux pump, permease component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatB; COG1668 981539002544 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 981539002545 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 981539002546 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 981539002547 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 981539002548 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 981539002549 active site 981539002550 homoserine O-succinyltransferase; Provisional; Region: PRK05368 981539002551 Type 1 glutamine amidotransferase (GATase1)-like domain found in homoserine trans-succinylase (HTS); Region: GATase1_HTS; cd03131 981539002552 proposed active site lysine [active] 981539002553 conserved cys residue [active] 981539002554 Putative primosome component and related proteins [DNA replication, recombination, and repair]; Region: DnaD; COG3935 981539002555 Replication initiation and membrane attachment; Region: DnaB_2; pfam07261 981539002556 Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177 981539002557 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 981539002558 minor groove reading motif; other site 981539002559 helix-hairpin-helix signature motif; other site 981539002560 substrate binding pocket [chemical binding]; other site 981539002561 active site 981539002562 iron-sulpphur binding domain in DNA-(apurinic or apyrimidinic site) lyase (subfamily of ENDO3); Region: FES; smart00525 981539002563 Predicted SAM-dependent methyltransferase [General function prediction only]; Region: COG2384 981539002564 Family of unknown function (DUF633); Region: DUF633; pfam04816 981539002565 Uncharacterized conserved protein [Function unknown]; Region: COG0327 981539002566 NIF3 (NGG1p interacting factor 3); Region: NIF3; pfam01784 981539002567 G1P_TT_short is the short form of glucose-1-phosphate thymidylyltransferase; Region: G1P_TT_short; cd02538 981539002568 glucose-1-phosphate thymidylyltransferase, short form; Region: rmlA; TIGR01207 981539002569 substrate binding site; other site 981539002570 tetramer interface; other site 981539002571 dTDP-4-dehydrorhamnose 3,5-epimerase and related enzymes [Cell envelope biogenesis, outer membrane]; Region: RfbC; COG1898 981539002572 dTDP-D-glucose 4,6-dehydratase [Cell envelope biogenesis, outer membrane]; Region: RfbB; COG1088 981539002573 dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246 981539002574 NAD binding site [chemical binding]; other site 981539002575 substrate binding site [chemical binding]; other site 981539002576 homodimer interface [polypeptide binding]; other site 981539002577 active site 981539002578 HD domain; Region: HD_4; pfam13328 981539002579 MutT homolog-1 (MTH1) is a member of the Nudix hydrolase superfamily. MTH1, the mammalian counterpart of MutT, hydrolyzes oxidized purine nucleoside triphosphates, such as 8-oxo-dGTP and 2-hydroxy-ATP, to monophosphates, thereby preventing the...; Region: MTH1; cd03427 981539002580 putative active site [active] 981539002581 nucleotide binding site [chemical binding]; other site 981539002582 nudix motif; other site 981539002583 putative metal binding site [ion binding]; other site 981539002584 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 981539002585 Domain of unknown function DUF20; Region: UPF0118; pfam01594 981539002586 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 981539002587 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 981539002588 TPR motif; other site 981539002589 binding surface 981539002590 Tetratricopeptide repeat; Region: TPR_12; pfam13424 981539002591 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 981539002592 binding surface 981539002593 TPR motif; other site 981539002594 Anaphase-promoting complex, cyclosome, subunit 3; Region: Apc3; pfam12895 981539002595 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 981539002596 dimerization interface [polypeptide binding]; other site 981539002597 putative DNA binding site [nucleotide binding]; other site 981539002598 putative Zn2+ binding site [ion binding]; other site 981539002599 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 981539002600 Old yellow enzyme (OYE)-related FMN binding domain, group 4. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a reducing agent with oxygens, quinones, and alpha,beta-unsaturated aldehydes and ketones, and can act as...; Region: OYE_like_4_FMN; cd04735 981539002601 putative active site [active] 981539002602 putative FMN binding site [chemical binding]; other site 981539002603 putative substrate binding site [chemical binding]; other site 981539002604 putative catalytic residue [active] 981539002605 acetolactate synthase; Reviewed; Region: PRK08617 981539002606 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 981539002607 PYR/PP interface [polypeptide binding]; other site 981539002608 dimer interface [polypeptide binding]; other site 981539002609 TPP binding site [chemical binding]; other site 981539002610 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 981539002611 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629 981539002612 TPP-binding site [chemical binding]; other site 981539002613 Alpha-acetolactate decarboxylase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: AlsD; COG3527 981539002614 amino acid transporter; Region: 2A0306; TIGR00909 981539002615 C-terminus of AA_permease; Region: AA_permease_C; pfam13906 981539002616 Fibronectin-binding protein A N-terminus (FbpA); Region: FbpA; pfam05833 981539002617 Domain of unknown function (DUF814); Region: DUF814; pfam05670 981539002618 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 981539002619 Transcriptional regulator [Transcription]; Region: LysR; COG0583 981539002620 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 981539002621 dimerization interface [polypeptide binding]; other site 981539002622 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 981539002623 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 981539002624 Walker A/P-loop; other site 981539002625 ATP binding site [chemical binding]; other site 981539002626 Q-loop/lid; other site 981539002627 ABC transporter signature motif; other site 981539002628 Walker B; other site 981539002629 D-loop; other site 981539002630 H-loop/switch region; other site 981539002631 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 981539002632 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 981539002633 dimer interface [polypeptide binding]; other site 981539002634 conserved gate region; other site 981539002635 putative PBP binding loops; other site 981539002636 ABC-ATPase subunit interface; other site 981539002637 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 981539002638 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 981539002639 substrate binding pocket [chemical binding]; other site 981539002640 membrane-bound complex binding site; other site 981539002641 hinge residues; other site 981539002642 N-Dimethylarginine dimethylaminohydrolase [Amino acid transport and metabolism]; Region: COG1834 981539002643 Amidinotransferase; Region: Amidinotransf; pfam02274 981539002644 Histidinol-phosphate/aromatic aminotransferase and cobyric acid decarboxylase [Amino acid transport and metabolism]; Region: HisC; COG0079 981539002645 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 981539002646 pyridoxal 5'-phosphate binding site [chemical binding]; other site 981539002647 homodimer interface [polypeptide binding]; other site 981539002648 catalytic residue [active] 981539002649 Formate/glycerate dehydrogenases, D-specific 2-hydroxy acid dehydrogenases and related dehydrogenases; Region: FDH_GDH_like; cl17240 981539002650 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052 981539002651 NAD binding site [chemical binding]; other site 981539002652 M20 Peptidase Arginine utilization protein, RocB; Region: M20_ArgE_RocB; cd05654 981539002653 putative metal binding site [ion binding]; other site 981539002654 putative dimer interface [polypeptide binding]; other site 981539002655 Type I periplasmic ligand-binding domain of uncharacterized ABC-type transport systems that are predicted to be involved in the uptake of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_uncharacterized_transporter; cd06325 981539002656 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 981539002657 zinc binding site [ion binding]; other site 981539002658 putative ligand binding site [chemical binding]; other site 981539002659 Transmembrane subunit (TM) of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which are involved in the uptake of branched-chain amino acids (AAs), as well as TMs of transporters involved in the uptake of...; Region: TM_PBP1_branched-chain-AA_like; cd06574 981539002660 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 981539002661 TM-ABC transporter signature motif; other site 981539002662 ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: PhnK; COG1101 981539002663 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 981539002664 Walker A/P-loop; other site 981539002665 ATP binding site [chemical binding]; other site 981539002666 Q-loop/lid; other site 981539002667 ABC transporter signature motif; other site 981539002668 Walker B; other site 981539002669 D-loop; other site 981539002670 H-loop/switch region; other site 981539002671 type VII secretion effector, SACOL2603 family; Region: T7SS_SACOL2603; TIGR04197 981539002672 mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595 981539002673 Metallo-beta-lactamase superfamily; Region: Lactamase_B; pfam00753 981539002674 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 981539002675 Zinc-dependent metalloprotease, MMP_like subfamily. This group contains matrix metalloproteinases (MMPs), serralysins, and the astacin_like family of proteases; Region: ZnMc_MMP_like; cd04268 981539002676 active site 981539002677 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 981539002678 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 981539002679 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 981539002680 ABC transporter; Region: ABC_tran_2; pfam12848 981539002681 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 981539002682 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 981539002683 MarR family; Region: MarR_2; pfam12802 981539002684 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 981539002685 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 981539002686 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 981539002687 Walker A/P-loop; other site 981539002688 ATP binding site [chemical binding]; other site 981539002689 Q-loop/lid; other site 981539002690 ABC transporter signature motif; other site 981539002691 Walker B; other site 981539002692 D-loop; other site 981539002693 H-loop/switch region; other site 981539002694 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 981539002695 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 981539002696 ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254 981539002697 Walker A/P-loop; other site 981539002698 ATP binding site [chemical binding]; other site 981539002699 Q-loop/lid; other site 981539002700 ABC transporter signature motif; other site 981539002701 Walker B; other site 981539002702 D-loop; other site 981539002703 H-loop/switch region; other site 981539002704 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, alpha subunit [Energy production and conversion]; Region: AcoA; COG1071 981539002705 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 981539002706 tetramer interface [polypeptide binding]; other site 981539002707 TPP-binding site [chemical binding]; other site 981539002708 heterodimer interface [polypeptide binding]; other site 981539002709 phosphorylation loop region [posttranslational modification] 981539002710 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 981539002711 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 981539002712 alpha subunit interface [polypeptide binding]; other site 981539002713 TPP binding site [chemical binding]; other site 981539002714 heterodimer interface [polypeptide binding]; other site 981539002715 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 981539002716 branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856 981539002717 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 981539002718 E3 interaction surface; other site 981539002719 lipoyl attachment site [posttranslational modification]; other site 981539002720 e3 binding domain; Region: E3_binding; pfam02817 981539002721 e3 binding domain; Region: E3_binding; pfam02817 981539002722 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 981539002723 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 981539002724 E3 interaction surface; other site 981539002725 lipoyl attachment site [posttranslational modification]; other site 981539002726 dihydrolipoamide dehydrogenase; Region: lipoamide_DH; TIGR01350 981539002727 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 981539002728 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 981539002729 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 981539002730 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 981539002731 ABC-ATPase subunit interface; other site 981539002732 dimer interface [polypeptide binding]; other site 981539002733 putative PBP binding regions; other site 981539002734 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 981539002735 ABC-ATPase subunit interface; other site 981539002736 dimer interface [polypeptide binding]; other site 981539002737 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 981539002738 putative PBP binding regions; other site 981539002739 ABC-type enterochelin transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CeuD; COG4604 981539002740 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 981539002741 Walker A/P-loop; other site 981539002742 ATP binding site [chemical binding]; other site 981539002743 Q-loop/lid; other site 981539002744 ABC transporter signature motif; other site 981539002745 Walker B; other site 981539002746 D-loop; other site 981539002747 H-loop/switch region; other site 981539002748 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 981539002749 Siderophore binding protein FatB. These proteins have been shown to function as ABC-type initial receptors in the siderophore-mediated iron uptake in some eubacterial species. They belong to the TroA superfamily of periplasmic metal binding proteins...; Region: FatB; cd01140 981539002750 putative ligand binding residues [chemical binding]; other site 981539002751 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 981539002752 EamA-like transporter family; Region: EamA; pfam00892 981539002753 EamA-like transporter family; Region: EamA; pfam00892 981539002754 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 981539002755 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 981539002756 DNA-binding site [nucleotide binding]; DNA binding site 981539002757 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 981539002758 pyridoxal 5'-phosphate binding site [chemical binding]; other site 981539002759 homodimer interface [polypeptide binding]; other site 981539002760 catalytic residue [active] 981539002761 Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095 981539002762 lipoyltransferase and lipoate-protein ligase; Region: lipoyltrans; TIGR00545 981539002763 Bacterial lipoate protein ligase C-terminus; Region: Lip_prot_lig_C; pfam10437 981539002764 Host cell surface-exposed lipoprotein; Region: Lipoprotein_Ltp; pfam07553 981539002765 Host cell surface-exposed lipoprotein; Region: Lipoprotein_Ltp; pfam07553 981539002766 Transcriptional regulator [Transcription]; Region: LysR; COG0583 981539002767 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 981539002768 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 981539002769 dimerization interface [polypeptide binding]; other site 981539002770 Protein of unknown function (DUF3737); Region: DUF3737; pfam12541 981539002771 Bifunctional PLP-dependent enzyme with beta-cystathionase and maltose regulon repressor activities [Amino acid transport and metabolism]; Region: MalY; COG1168 981539002772 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 981539002773 pyridoxal 5'-phosphate binding site [chemical binding]; other site 981539002774 homodimer interface [polypeptide binding]; other site 981539002775 catalytic residue [active] 981539002776 Uncharacterized conserved protein [Function unknown]; Region: COG4925 981539002777 Uncharacterized conserved protein [Function unknown]; Region: COG4925 981539002778 Predicted flavin-nucleotide-binding protein [General function prediction only]; Region: COG3467 981539002779 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Thermotoga marina NorM; Region: MATE_NorM_like; cd13137 981539002780 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 981539002781 Pyrimidine reductase, riboflavin biosynthesis [Coenzyme metabolism]; Region: RibD; COG1985 981539002782 RibD C-terminal domain; Region: RibD_C; cl17279 981539002783 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 981539002784 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 981539002785 putative substrate translocation pore; other site 981539002786 Hydrolases of the alpha/beta superfamily [General function prediction only]; Region: COG1073 981539002787 Domain of unknown function (DUF4353); Region: DUF4353; pfam14262 981539002788 Domain of unknown function (DUF4353); Region: DUF4353; pfam14262 981539002789 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 981539002790 Major Facilitator Superfamily; Region: MFS_1; pfam07690 981539002791 putative substrate translocation pore; other site 981539002792 flavocytochrome c; Region: flavo_cyto_c; TIGR01813 981539002793 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 981539002794 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 981539002795 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 981539002796 Predicted flavoprotein [General function prediction only]; Region: COG0431 981539002797 Predicted flavoprotein [General function prediction only]; Region: COG0431 981539002798 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 981539002799 hypothetical protein; Provisional; Region: PRK04143 981539002800 ADP-ribose binding site [chemical binding]; other site 981539002801 Transcriptional regulators CsoR (copper-sensitive operon repressor), RcnR, and FrmR, and related domains; this domain superfamily was previously known as DUF156; Region: CsoR-like_DUF156; cl00846 981539002802 putative homotetramer interface [polypeptide binding]; other site 981539002803 putative homodimer interface [polypeptide binding]; other site 981539002804 putative allosteric switch controlling residues; other site 981539002805 putative metal binding site [ion binding]; other site 981539002806 putative homodimer-homodimer interface [polypeptide binding]; other site 981539002807 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 981539002808 active site residue [active] 981539002809 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 981539002810 CoA-disulfide reductase; Region: CoA_CoA_reduc; TIGR03385 981539002811 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 981539002812 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 981539002813 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125 981539002814 active site residue [active] 981539002815 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 981539002816 active site residue [active] 981539002817 Predicted HD superfamily hydrolase [General function prediction only]; Region: COG1418 981539002818 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 981539002819 Zn2+ binding site [ion binding]; other site 981539002820 Mg2+ binding site [ion binding]; other site 981539002821 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 981539002822 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 981539002823 Coenzyme A binding pocket [chemical binding]; other site 981539002824 Protein of unknown function (DUF2974); Region: DUF2974; pfam11187 981539002825 Transcriptional regulator [Transcription]; Region: LysR; COG0583 981539002826 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 981539002827 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 981539002828 dimerization interface [polypeptide binding]; other site 981539002829 Uncharacterized homolog of gamma-carboxymuconolactone decarboxylase subunit [Function unknown]; Region: COG0599 981539002830 Uncharacterized homolog of gamma-carboxymuconolactone decarboxylase subunit [Function unknown]; Region: COG0599 981539002831 short chain dehydrogenase; Provisional; Region: PRK06940 981539002832 classical (c) SDRs; Region: SDR_c; cd05233 981539002833 NAD(P) binding site [chemical binding]; other site 981539002834 active site 981539002835 Uncharacterized oxidoreductases, Fe-dependent alcohol dehydrogenase family [Energy production and conversion]; Region: COG1979 981539002836 Dehydroquinate synthase-like (DHQ-like) and iron-containing alcohol dehydrogenases (Fe-ADH); Region: DHQ_Fe-ADH; cl02872 981539002837 active site 981539002838 NAD binding site [chemical binding]; other site 981539002839 metal binding site [ion binding]; metal-binding site 981539002840 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 981539002841 NADH(P)-binding; Region: NAD_binding_10; pfam13460 981539002842 NAD(P) binding site [chemical binding]; other site 981539002843 active site 981539002844 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 981539002845 Helix-Turn-Helix DNA binding domain of the MerR-like transcription regulators YyaN and YraB; Region: HTH_YyaN; cd01109 981539002846 DNA binding residues [nucleotide binding] 981539002847 putative dimer interface [polypeptide binding]; other site 981539002848 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 981539002849 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 981539002850 active site 981539002851 catalytic tetrad [active] 981539002852 Uncharacterized homolog of gamma-carboxymuconolactone decarboxylase subunit [Function unknown]; Region: COG0599 981539002853 Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1917 981539002854 Flagellin N-methylase; Region: FliB; pfam03692 981539002855 HAD superfamily (subfamily IA) hydrolase, TIGR02254; Region: YjjG/YfnB 981539002856 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 981539002857 motif II; other site 981539002858 Lanthionine synthetase C-like protein; Region: LANC_like; pfam05147 981539002859 LanC-like proteins. LanC is the cyclase enzyme of the lanthionine synthetase. Lanthionine is a lantibiotic, a unique class of peptide antibiotics. They are ribosomally synthesized as a precursor peptide and then post-translationally modified to contain...; Region: LanC_like; cd04434 981539002860 active site 981539002861 zinc binding site [ion binding]; other site 981539002862 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 981539002863 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 981539002864 dimer interface [polypeptide binding]; other site 981539002865 pyridoxal 5'-phosphate binding site [chemical binding]; other site 981539002866 catalytic residue [active] 981539002867 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 981539002868 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 981539002869 ligand binding site [chemical binding]; other site 981539002870 flexible hinge region; other site 981539002871 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 981539002872 non-specific DNA interactions [nucleotide binding]; other site 981539002873 DNA binding site [nucleotide binding] 981539002874 sequence specific DNA binding site [nucleotide binding]; other site 981539002875 putative cAMP binding site [chemical binding]; other site 981539002876 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 981539002877 LysR transcriptional regulator; Provisional; Region: rbcR; CHL00180 981539002878 C-terminal substrate binding domain of LysR-type transcriptional regulator CysL, which activates the transcription of the cysJI operon encoding sulfite reductase, contains the type 2 periplasmic binding fold; Region: PBP2_CysL_like; cd08420 981539002879 putative dimerization interface [polypeptide binding]; other site 981539002880 Predicted membrane protein [Function unknown]; Region: COG2855 981539002881 NAD-dependent aldehyde dehydrogenases [Energy production and conversion]; Region: PutA; COG1012 981539002882 Mycobacterium tuberculosis succinate-semialdehyde dehydrogenase 1-like; Region: ALDH_SSADH1_GabD1; cd07100 981539002883 NAD(P) binding site [chemical binding]; other site 981539002884 catalytic residues [active] 981539002885 Bacterial low temperature requirement A protein (LtrA); Region: LtrA; cl01754 981539002886 excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558 981539002887 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 981539002888 GIY-YIG motif/motif A; other site 981539002889 active site 981539002890 catalytic site [active] 981539002891 putative DNA binding site [nucleotide binding]; other site 981539002892 metal binding site [ion binding]; metal-binding site 981539002893 UvrB/uvrC motif; Region: UVR; pfam02151 981539002894 UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459 981539002895 Bacteriophage abortive infection AbiH; Region: AbiH; pfam14253 981539002896 Uncharacterized conserved protein [Function unknown]; Region: COG3603 981539002897 Family description; Region: ACT_7; pfam13840 981539002898 Nitroreductase-like family 1. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_1; cd02137 981539002899 dimer interface [polypeptide binding]; other site 981539002900 FMN binding site [chemical binding]; other site 981539002901 dipeptidase PepV; Reviewed; Region: PRK07318 981539002902 M20 Peptidase Xaa-His dipeptidase (PepV) degrades hydrophobic dipeptides; Region: M20_PepV; cd03888 981539002903 active site 981539002904 metal binding site [ion binding]; metal-binding site 981539002905 Uncharacterized subfamily of Uracil-DNA glycosylases; Region: UDG_like_1; cd10033 981539002906 putative uracil binding site [chemical binding]; other site 981539002907 putative active site [active] 981539002908 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 981539002909 Cyclic nucleotide-binding domain; Region: cNMP_binding; pfam00027 981539002910 ligand binding site [chemical binding]; other site 981539002911 flexible hinge region; other site 981539002912 Crp-like helix-turn-helix domain; Region: HTH_Crp_2; pfam13545 981539002913 tRNA modification GTPase TrmE; Reviewed; Region: trmE; PRK05291 981539002914 GTP-binding protein TrmE N-terminus; Region: TrmE_N; pfam10396 981539002915 trmE is a tRNA modification GTPase; Region: trmE; cd04164 981539002916 G1 box; other site 981539002917 GTP/Mg2+ binding site [chemical binding]; other site 981539002918 Switch I region; other site 981539002919 G2 box; other site 981539002920 Switch II region; other site 981539002921 G3 box; other site 981539002922 G4 box; other site 981539002923 G5 box; other site 981539002924 Catalytic cysteine-containing C-terminus of GTPase, MnmE; Region: GTPase_Cys_C; pfam12631 981539002925 RPI_A: Ribose 5-phosphate isomerase type A (RPI_A) subfamily; RPI catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate, the first step of the non-oxidative branch of the pentose phosphate pathway. This reaction leads to the...; Region: RPI_A; cd01398 981539002926 tetramer (dimer of dimers) interface [polypeptide binding]; other site 981539002927 active site 981539002928 dimer interface [polypeptide binding]; other site 981539002929 phosphopentomutase; Provisional; Region: PRK05362 981539002930 Metalloenzyme superfamily; Region: Metalloenzyme; pfam01676 981539002931 purine nucleoside phosphorylase; Provisional; Region: PRK08202 981539002932 GMP synthase - Glutamine amidotransferase domain [Nucleotide transport and metabolism]; Region: GuaA; COG0518 981539002933 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_1; cd01741 981539002934 catalytic triad [active] 981539002935 Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038 981539002936 Putative ClC chloride channel. Clc proteins are putative halogen ion (Cl-, Br- and I-) transporters found in eubacteria. They belong to the ClC superfamily of halogen ion channels, which share a unique double-barreled architecture and voltage-dependent...; Region: ClC_like; cd01033 981539002937 putative ion selectivity filter; other site 981539002938 putative pore gating glutamate residue; other site 981539002939 purine nucleoside phosphorylase; Reviewed; Region: deoD; PRK05819 981539002940 Uridine phosphorylase [Nucleotide transport and metabolism]; Region: Udp; COG2820 981539002941 CRISPR/Cas system-associated protein Csm6; Region: Csm6_III-A; cl09873 981539002942 Transcriptional regulator [Transcription]; Region: LysR; COG0583 981539002943 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 981539002944 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 981539002945 dimerization interface [polypeptide binding]; other site 981539002946 DNA polymerase processivity factor; Region: DNA_PPF; pfam02916 981539002947 Cell envelope-related transcriptional attenuator domain; Region: LytR_cpsA_psr; pfam03816 981539002948 Capsular polysaccharide biosynthesis protein [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: CapC; COG4464 981539002949 polysaccharide export protein, MPA1 family, Gram-positive type; Region: polys_exp_MPA1; TIGR01006 981539002950 Capsular polysaccharide biosynthesis protein [Cell envelope biogenesis, outer membrane]; Region: COG3944 981539002951 capsular exopolysaccharide family; Region: eps_fam; TIGR01007 981539002952 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 981539002953 exopolysaccharide biosynthesis polyprenyl glycosylphosphotransferase; Region: EPS_sugtrans; TIGR03025 981539002954 Bacterial sugar transferase; Region: Bac_transf; pfam02397 981539002955 Oligosaccharide biosynthesis protein Alg14 like; Region: Alg14; pfam08660 981539002956 Glycosyltransferase family 28 C-terminal domain; Region: Glyco_tran_28_C; pfam04101 981539002957 Predicted hydrolase (HAD superfamily) [General function prediction only]; Region: COG5610 981539002958 Haloacid dehalogenase-like hydrolase; Region: HAD_2; pfam13419 981539002959 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 981539002960 This family is most closely related to the GT1 family of glycosyltransferases. capH in Staphylococcus aureus has been shown to be required for the biosynthesis of the type 1 capsular polysaccharide (CP1); Region: GT1_CapH_like; cd03812 981539002961 putative ADP-binding pocket [chemical binding]; other site 981539002962 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 981539002963 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 981539002964 active site 981539002965 truncated polysaccharide polymerase 981539002966 truncated polysaccharide polymerase 981539002967 Glycosyltransferase sugar-binding region containing DXD motif; Region: Gly_transf_sug; pfam04488 981539002968 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 981539002969 Wzx, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_Wzx_like; cd13128 981539002970 Polysaccharide pyruvyl transferase; Region: PS_pyruv_trans; pfam04230 981539002971 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 981539002972 active site 981539002973 3-oxoacyl-(acyl-carrier-protein) reductase; Region: 3oxo_ACP_reduc; TIGR01830 981539002974 classical (c) SDRs; Region: SDR_c; cd05233 981539002975 NAD(P) binding site [chemical binding]; other site 981539002976 active site 981539002977 Transposase DDE domain; Region: DDE_Tnp_1_3; pfam13612 981539002978 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 981539002979 truncated abortive infection system Abi protein 981539002980 truncated abortive infection system Abi protein 981539002981 PemK-like protein; Region: PemK; pfam02452 981539002982 Antidote-toxin recognition MazE; Region: Antitoxin-MazE; cl00877 981539002983 truncated IS861, transposase 981539002984 truncated IS861, transposase 981539002985 HTH-like domain; Region: HTH_21; pfam13276 981539002986 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 981539002987 Integrase core domain; Region: rve; pfam00665 981539002988 Integrase core domain; Region: rve_2; pfam13333 981539002989 dihydroorotate dehydrogenase electron transfer subunit; Reviewed; Region: PRK00054 981539002990 FAD/NAD binding domain in the electron transfer subunit of dihydroorotate dehydrogenase. Dihydroorotate dehydrogenases (DHODs) catalyze the only redox reaction in pyrimidine de novo biosynthesis. They catalyze the oxidation of (S)-dihydroorotate to...; Region: DHOD_e_trans; cd06218 981539002991 FAD binding pocket [chemical binding]; other site 981539002992 FAD binding motif [chemical binding]; other site 981539002993 phosphate binding motif [ion binding]; other site 981539002994 beta-alpha-beta structure motif; other site 981539002995 NAD binding pocket [chemical binding]; other site 981539002996 Iron coordination center [ion binding]; other site 981539002997 dihydroorotate dehydrogenase (subfamily 1) family protein; Region: pyrD_sub1_fam; TIGR01037 981539002998 Dihydroorotate dehydrogenase (DHOD) class 1B FMN-binding domain. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine...; Region: DHOD_1B_like; cd04740 981539002999 heterodimer interface [polypeptide binding]; other site 981539003000 active site 981539003001 FMN binding site [chemical binding]; other site 981539003002 homodimer interface [polypeptide binding]; other site 981539003003 substrate binding site [chemical binding]; other site 981539003004 Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725 981539003005 active site 981539003006 dimer interface [polypeptide binding]; other site 981539003007 Inorganic pyrophosphatase. These enzymes hydrolyze inorganic pyrophosphate (PPi) to two molecules of orthophosphates (Pi). The reaction requires bivalent cations. The enzymes in general exist as homooligomers; Region: pyrophosphatase; cl00217 981539003008 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 981539003009 active site 981539003010 PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in bacteria and archaea; Region: PEBP_bact_arch; cd00865 981539003011 substrate binding site [chemical binding]; other site 981539003012 Family 1 of Uracil-DNA glycosylase (UDG) enzymes; Region: UDG_F1; cd10027 981539003013 ligand binding site [chemical binding]; other site 981539003014 active site 981539003015 UGI interface [polypeptide binding]; other site 981539003016 catalytic site [active] 981539003017 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 981539003018 conserved cys residue [active] 981539003019 dihydroorotase; Validated; Region: pyrC; PRK09357 981539003020 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 981539003021 Dihydroorotase (DHOase), subgroup IIa; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This subgroup also contains proteins that lack the active site, like unc-33, a C; Region: DHOase_IIa; cd01317 981539003022 active site 981539003023 putative glycerol-3-phosphate acyltransferase PlsY; Provisional; Region: PRK00220 981539003024 DNA topoisomerase IV, B subunit, Gram-positive; Region: parE_Gpos; TIGR01058 981539003025 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 981539003026 Mg2+ binding site [ion binding]; other site 981539003027 G-X-G motif; other site 981539003028 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 981539003029 anchoring element; other site 981539003030 dimer interface [polypeptide binding]; other site 981539003031 ATP binding site [chemical binding]; other site 981539003032 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 981539003033 active site 981539003034 putative metal-binding site [ion binding]; other site 981539003035 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 981539003036 DNA topoisomerase IV, A subunit, Gram-positive; Region: parC_Gpos; TIGR01061 981539003037 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 981539003038 CAP-like domain; other site 981539003039 active site 981539003040 primary dimer interface [polypeptide binding]; other site 981539003041 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 981539003042 branched-chain amino acid aminotransferase; Provisional; Region: PRK13357 981539003043 BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557 981539003044 homodimer interface [polypeptide binding]; other site 981539003045 substrate-cofactor binding pocket; other site 981539003046 catalytic residue [active] 981539003047 Protein of unknown function (DUF2969); Region: DUF2969; pfam11184 981539003048 30S ribosomal protein S1; Reviewed; Region: rpsA; PRK06676 981539003049 S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687 981539003050 RNA binding site [nucleotide binding]; other site 981539003051 S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465 981539003052 RNA binding site [nucleotide binding]; other site 981539003053 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 981539003054 RNA binding site [nucleotide binding]; other site 981539003055 S1_RPS1_repeat_hs4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_hs4; cd05692 981539003056 RNA binding site [nucleotide binding]; other site 981539003057 LrgB-like family; Region: LrgB; pfam04172 981539003058 truncated LrgA-like murein hydrolase/penicillin tolerance regulator 981539003059 truncated LrgA-like murein hydrolase/penicillin tolerance regulator 981539003060 Uncharacterized conserved protein [Function unknown]; Region: COG0398 981539003061 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 981539003062 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 981539003063 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 981539003064 Walker A/P-loop; other site 981539003065 ATP binding site [chemical binding]; other site 981539003066 Q-loop/lid; other site 981539003067 ABC transporter signature motif; other site 981539003068 Walker B; other site 981539003069 D-loop; other site 981539003070 H-loop/switch region; other site 981539003071 Predicted transcriptional regulators [Transcription]; Region: COG1725 981539003072 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 981539003073 DNA-binding site [nucleotide binding]; DNA binding site 981539003074 DNA polymerase III DnaE; Reviewed; Region: dnaE; PRK07279 981539003075 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III; Region: PHP_PolIIIA; cd07431 981539003076 active site 981539003077 PHP Thumb interface [polypeptide binding]; other site 981539003078 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 981539003079 generic binding surface II; other site 981539003080 generic binding surface I; other site 981539003081 6-phosphofructokinase; Provisional; Region: PRK03202 981539003082 6-phosphofructokinase; Region: PFKA_ATP; TIGR02482 981539003083 active site 981539003084 ADP/pyrophosphate binding site [chemical binding]; other site 981539003085 dimerization interface [polypeptide binding]; other site 981539003086 allosteric effector site; other site 981539003087 fructose-1,6-bisphosphate binding site; other site 981539003088 pyruvate kinase; Provisional; Region: PRK05826 981539003089 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342 981539003090 domain interfaces; other site 981539003091 active site 981539003092 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 981539003093 The S24, S26 LexA/signal peptidase superfamily contains LexA-related and type I signal peptidase families. The S24 LexA protein domains include: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC 3.4.21.88), the...; Region: Peptidase_S24_S26; cl10465 981539003094 Catalytic site [active] 981539003095 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 981539003096 glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331 981539003097 Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans). The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714 981539003098 glutaminase active site [active] 981539003099 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 981539003100 dimer interface [polypeptide binding]; other site 981539003101 active site 981539003102 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 981539003103 dimer interface [polypeptide binding]; other site 981539003104 active site 981539003105 Phosphotransferase system, mannitol-specific IIBC component [Carbohydrate transport and metabolism]; Region: MtlA; COG2213 981539003106 PTS system, mannitol-specific IIC component; Region: mtlA; TIGR00851 981539003107 PTS_IIB_mannitol: subunit IIB of enzyme II (EII) of the mannitol-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is a mannitol-specific permease with two cytoplasmic domains (IIA and IIB) and a transmembrane...; Region: PTS_IIB_mannitol; cd05567 981539003108 active site 981539003109 P-loop; other site 981539003110 phosphorylation site [posttranslational modification] 981539003111 PTS_IIB_mannitol: subunit IIB of enzyme II (EII) of the mannitol-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is a mannitol-specific permease with two cytoplasmic domains (IIA and IIB) and a transmembrane...; Region: PTS_IIB_mannitol; cd05567 981539003112 active site 981539003113 P-loop; other site 981539003114 phosphorylation site [posttranslational modification] 981539003115 Transcriptional antiterminator [Transcription]; Region: BglG; COG3711 981539003116 HTH domain; Region: HTH_11; pfam08279 981539003117 HTH domain; Region: HTH_11; pfam08279 981539003118 PTS_IIB: subunit IIB of enzyme II (EII) is the central energy-coupling domain of the phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In the multienzyme PTS complex, EII is a carbohydrate-specific permease consisting of two cytoplasmic...; Region: PTS_IIB; cl10014 981539003119 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cl00163 981539003120 active site 981539003121 phosphorylation site [posttranslational modification] 981539003122 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 981539003123 active site 981539003124 phosphorylation site [posttranslational modification] 981539003125 mannitol-1-phosphate 5-dehydrogenase; Provisional; Region: PRK02318 981539003126 Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232 981539003127 Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125 981539003128 Uncharacterized Zn-ribbon-containing protein involved in phosphonate metabolism [Inorganic ion transport and metabolism]; Region: PhnA; COG2824 981539003129 PhnA Zinc-Ribbon; Region: PhnA_Zn_Ribbon; pfam08274 981539003130 PhnA protein; Region: PhnA; pfam03831 981539003131 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 981539003132 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 981539003133 dimer interface [polypeptide binding]; other site 981539003134 conserved gate region; other site 981539003135 ABC-ATPase subunit interface; other site 981539003136 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 981539003137 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 981539003138 Walker A/P-loop; other site 981539003139 ATP binding site [chemical binding]; other site 981539003140 Q-loop/lid; other site 981539003141 ABC transporter signature motif; other site 981539003142 Walker B; other site 981539003143 D-loop; other site 981539003144 H-loop/switch region; other site 981539003145 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 981539003146 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 981539003147 substrate binding pocket [chemical binding]; other site 981539003148 membrane-bound complex binding site; other site 981539003149 hinge residues; other site 981539003150 truncated cation efflux family protein 981539003151 truncated cation efflux family protein 981539003152 Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115 981539003153 Sodium:alanine symporter family; Region: Na_Ala_symp; cl00548 981539003154 Glycosyl hydrolase family 1; Region: Glyco_hydro_1; cl01046 981539003155 beta-galactosidase; Region: BGL; TIGR03356 981539003156 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 981539003157 catalytic core [active] 981539003158 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 981539003159 catalytic core [active] 981539003160 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 981539003161 catalytic core [active] 981539003162 Domain of unknown function DUF20; Region: UPF0118; pfam01594 981539003163 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 981539003164 A4GalT_like proteins catalyze the addition of galactose or glucose residues to the lipooligosaccharide (LOS) or lipopolysaccharide (LPS) of the bacterial cell surface; Region: GT8_A4GalT_like; cd04194 981539003165 Glycosyl transferase family 8; Region: Glyco_transf_8; pfam01501 981539003166 Ligand binding site; other site 981539003167 metal-binding site 981539003168 hypothetical protein; Reviewed; Region: PRK00024 981539003169 Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071 981539003170 MPN+ (JAMM) motif; other site 981539003171 Zinc-binding site [ion binding]; other site 981539003172 redox-sensing transcriptional repressor Rex; Provisional; Region: PRK05472 981539003173 Putative DNA-binding protein N-terminus; Region: Put_DNA-bind_N; pfam06971 981539003174 CoA binding domain; Region: CoA_binding; pfam02629 981539003175 Putative amino acid metabolism; Region: DUF1831; pfam08866 981539003176 Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104 981539003177 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 981539003178 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 981539003179 catalytic residue [active] 981539003180 ribose-phosphate pyrophosphokinase; Provisional; Region: PRK02458 981539003181 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 981539003182 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 981539003183 active site 981539003184 Uncharacterized subgroup 1 of the CYTH-like superfamily; Region: CYTH-like_Pase_1; cd07762 981539003185 putative active site [active] 981539003186 putative metal binding residues [ion binding]; other site 981539003187 signature motif; other site 981539003188 putative triphosphate binding site [ion binding]; other site 981539003189 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 981539003190 synthetase active site [active] 981539003191 NTP binding site [chemical binding]; other site 981539003192 metal binding site [ion binding]; metal-binding site 981539003193 inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK04885 981539003194 ATP-NAD kinase; Region: NAD_kinase; pfam01513 981539003195 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 981539003196 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 981539003197 active site 981539003198 phosphotransacetylase; Reviewed; Region: eutD; PRK09653 981539003199 classical (c) SDR, subgroup 5; Region: SDR_c5; cd05346 981539003200 malonic semialdehyde reductase; Provisional; Region: PRK10538 981539003201 putative NAD(P) binding site [chemical binding]; other site 981539003202 homodimer interface [polypeptide binding]; other site 981539003203 homotetramer interface [polypeptide binding]; other site 981539003204 active site 981539003205 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 981539003206 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 981539003207 active site 981539003208 motif I; other site 981539003209 motif II; other site 981539003210 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 981539003211 Beta-glucosidase/6-phospho-beta-glucosidase/beta- galactosidase [Carbohydrate transport and metabolism]; Region: BglB; COG2723 981539003212 beta-galactosidase; Region: BGL; TIGR03356 981539003213 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 981539003214 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 981539003215 Walker A/P-loop; other site 981539003216 ATP binding site [chemical binding]; other site 981539003217 Q-loop/lid; other site 981539003218 ABC transporter signature motif; other site 981539003219 Walker B; other site 981539003220 D-loop; other site 981539003221 H-loop/switch region; other site 981539003222 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 981539003223 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 981539003224 FtsX-like permease family; Region: FtsX; pfam02687 981539003225 guanosine 5'-monophosphate oxidoreductase; Provisional; Region: PRK05458 981539003226 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 981539003227 active site 981539003228 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 981539003229 Predicted transcriptional regulator [Transcription]; Region: COG2378 981539003230 HTH domain; Region: HTH_11; pfam08279 981539003231 WYL domain; Region: WYL; pfam13280 981539003232 Protein of unknown function (DUF1211); Region: DUF1211; cl01421 981539003233 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 981539003234 active site 981539003235 xanthine permease; Region: pbuX; TIGR03173 981539003236 Sulfate transporter family; Region: Sulfate_transp; pfam00916 981539003237 Membrane-associated lipoprotein involved in thiamine biosynthesis [Coenzyme metabolism]; Region: ApbE; COG1477 981539003238 ApbE family; Region: ApbE; pfam02424 981539003239 4-oxalocrotonate tautomerase; Provisional; Region: PRK02289 981539003240 active site 1 [active] 981539003241 dimer interface [polypeptide binding]; other site 981539003242 hexamer interface [polypeptide binding]; other site 981539003243 active site 2 [active] 981539003244 thymidine kinase; Provisional; Region: PRK04296 981539003245 peptide chain release factor 1; Validated; Region: prfA; PRK00591 981539003246 This domain is found in peptide chain release factors; Region: PCRF; smart00937 981539003247 RF-1 domain; Region: RF-1; pfam00472 981539003248 N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328 981539003249 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 981539003250 S-adenosylmethionine binding site [chemical binding]; other site 981539003251 Putative translation factor (SUA5) [Translation, ribosomal structure and biogenesis]; Region: SUA5; COG0009 981539003252 serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011 981539003253 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378 981539003254 dimer interface [polypeptide binding]; other site 981539003255 active site 981539003256 glycine-pyridoxal phosphate binding site [chemical binding]; other site 981539003257 folate binding site [chemical binding]; other site 981539003258 37-kD nucleoid-associated bacterial protein; Region: NA37; cl15473 981539003259 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 981539003260 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 981539003261 N-acetyl-D-glucosamine binding site [chemical binding]; other site 981539003262 catalytic residue [active] 981539003263 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 981539003264 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 981539003265 ATP-binding cassette domain of multidrug resistance protein-like transporters; Region: ABCC_MRP_Like; cd03228 981539003266 Walker A/P-loop; other site 981539003267 ATP binding site [chemical binding]; other site 981539003268 Q-loop/lid; other site 981539003269 ABC transporter signature motif; other site 981539003270 Walker B; other site 981539003271 D-loop; other site 981539003272 H-loop/switch region; other site 981539003273 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 981539003274 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 981539003275 ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254 981539003276 Walker A/P-loop; other site 981539003277 ATP binding site [chemical binding]; other site 981539003278 Q-loop/lid; other site 981539003279 ABC transporter signature motif; other site 981539003280 Walker B; other site 981539003281 D-loop; other site 981539003282 H-loop/switch region; other site 981539003283 cytoplasmic alpha-amylase; Reviewed; Region: PRK09441 981539003284 Alpha amylase catalytic domain found in bacterial and fungal Alpha amylases (also called 1,4-alpha-D-glucan-4-glucanohydrolase); Region: AmyAc_bac_fung_AmyA; cd11318 981539003285 active site 981539003286 Na/Ca binding site [ion binding]; other site 981539003287 catalytic site [active] 981539003288 Domain of unknown function (DUF1939); Region: DUF1939; pfam09154 981539003289 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 981539003290 Uncharacterized conserved protein [Function unknown]; Region: COG0398 981539003291 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 981539003292 CAT RNA binding domain; Region: CAT_RBD; smart01061 981539003293 transcriptional antiterminator BglG; Provisional; Region: PRK09772 981539003294 PRD domain; Region: PRD; pfam00874 981539003295 PRD domain; Region: PRD; pfam00874 981539003296 PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_lac; cd00215 981539003297 methionine cluster; other site 981539003298 active site 981539003299 phosphorylation site [posttranslational modification] 981539003300 metal binding site [ion binding]; metal-binding site 981539003301 phosphotransferase system, lactose specific, IIC component; Region: lac_pts_IIC; TIGR00394 981539003302 Phosphotransferase system, EIIC; Region: PTS_EIIC; pfam02378 981539003303 PTS_IIB: subunit IIB of enzyme II (EII) is the central energy-coupling domain of the phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In the multienzyme PTS complex, EII is a carbohydrate-specific permease consisting of two cytoplasmic...; Region: PTS_IIB; cl10014 981539003304 active site 981539003305 P-loop; other site 981539003306 phosphorylation site [posttranslational modification] 981539003307 6-phospho-beta-galactosidase; Provisional; Region: PRK13511 981539003308 beta-galactosidase; Region: BGL; TIGR03356 981539003309 GMP synthase; Reviewed; Region: guaA; PRK00074 981539003310 Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742 981539003311 AMP/PPi binding site [chemical binding]; other site 981539003312 candidate oxyanion hole; other site 981539003313 catalytic triad [active] 981539003314 potential glutamine specificity residues [chemical binding]; other site 981539003315 The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997 981539003316 ATP Binding subdomain [chemical binding]; other site 981539003317 Dimerization subdomain; other site 981539003318 Methyltransferase domain; Region: Methyltransf_31; pfam13847 981539003319 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 981539003320 S-adenosylmethionine binding site [chemical binding]; other site 981539003321 This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784 981539003322 glycosyltransferase, MGT family; Region: MGT; TIGR01426 981539003323 active site 981539003324 TDP-binding site; other site 981539003325 acceptor substrate-binding pocket; other site 981539003326 homodimer interface [polypeptide binding]; other site 981539003327 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 981539003328 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 981539003329 non-specific DNA binding site [nucleotide binding]; other site 981539003330 salt bridge; other site 981539003331 sequence-specific DNA binding site [nucleotide binding]; other site 981539003332 transcriptional activator, Rgg/GadR/MutR family, C-terminal domain; Region: RGG_Cterm; TIGR01716 981539003333 Glycosyl hydrolase family 70; Region: Glyco_hydro_70; pfam02324 981539003334 Alpha amylase catalytic domain family; Region: AmyAc_family; cl07893 981539003335 glucan-binding repeat; Region: glucan_65_rpt; TIGR04035 981539003336 glucan-binding repeat; Region: glucan_65_rpt; TIGR04035 981539003337 glucan-binding repeat; Region: glucan_65_rpt; TIGR04035 981539003338 glucan-binding repeat; Region: glucan_65_rpt; TIGR04035 981539003339 glucan-binding repeat; Region: glucan_65_rpt; TIGR04035 981539003340 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 981539003341 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 981539003342 non-specific DNA binding site [nucleotide binding]; other site 981539003343 salt bridge; other site 981539003344 sequence-specific DNA binding site [nucleotide binding]; other site 981539003345 transcriptional activator, Rgg/GadR/MutR family, C-terminal domain; Region: RGG_Cterm; TIGR01716 981539003346 glucan-binding repeat; Region: glucan_65_rpt; TIGR04035 981539003347 Glycosyl hydrolase family 70; Region: Glyco_hydro_70; pfam02324 981539003348 Alpha amylase catalytic domain family; Region: AmyAc_family; cl07893 981539003349 glucan-binding repeat; Region: glucan_65_rpt; TIGR04035 981539003350 glucan-binding repeat; Region: glucan_65_rpt; TIGR04035 981539003351 glucan-binding repeat; Region: glucan_65_rpt; TIGR04035 981539003352 glucan-binding repeat; Region: glucan_65_rpt; TIGR04035 981539003353 glucan-binding repeat; Region: glucan_65_rpt; TIGR04035 981539003354 glucan-binding repeat; Region: glucan_65_rpt; TIGR04035 981539003355 Glucan-binding protein C; Region: GbpC; pfam08363 981539003356 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 981539003357 Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; Region: MATE_like_8; cd13134 981539003358 dihydroxyacetone kinase subunit DhaK; Provisional; Region: PRK14481; cl10557 981539003359 Dihydroxyacetone kinase [Carbohydrate transport and metabolism]; Region: DAK1; COG2376 981539003360 probable dihydroxyacetone kinase regulator; Region: DHAK_reg; TIGR02366 981539003361 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 981539003362 dihydroxyacetone kinase subunit DhaK; Provisional; Region: PRK14481 981539003363 Dihydroxyacetone kinase [Carbohydrate transport and metabolism]; Region: DAK1; COG2376 981539003364 dihydroxyacetone kinase, phosphoprotein-dependent, L subunit; Region: dha_L_ycgS; TIGR02365 981539003365 phosphotransferase mannnose-specific family component IIA; Provisional; Region: PRK14484 981539003366 Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cd00333 981539003367 amphipathic channel; other site 981539003368 Asn-Pro-Ala signature motifs; other site 981539003369 Zeta toxin; Region: Zeta_toxin; pfam06414 981539003370 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4185 981539003371 GIY-YIG domain of uncharacterized bacterial protein structurally related to COG3410; Region: GIY-YIG_COG3410; cd10439 981539003372 GIY-YIG motif/motif A; other site 981539003373 putative active site [active] 981539003374 putative metal binding site [ion binding]; other site 981539003375 AAA domain; Region: AAA_30; pfam13604 981539003376 Uncharacterized conserved protein (DUF2075); Region: DUF2075; pfam09848 981539003377 Uncharacterized conserved protein [Function unknown]; Region: COG3410 981539003378 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 981539003379 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 981539003380 DNA-binding site [nucleotide binding]; DNA binding site 981539003381 UTRA domain; Region: UTRA; pfam07702 981539003382 truncated RpiR family regulatory protein 981539003383 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 981539003384 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 981539003385 Domain of unknown function (DUF336); Region: DUF336; cl01249 981539003386 putative oxidoreductase; Provisional; Region: PRK10206 981539003387 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 981539003388 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 981539003389 Plasmid encoded toxin Txe; Region: Plasmid_Txe; cl17389 981539003390 Antitoxin Phd_YefM, type II toxin-antitoxin system; Region: PhdYeFM_antitox; pfam02604 981539003391 Putative helix-turn-helix protein, YlxM / p13 like; Region: UPF0122; pfam04297 981539003392 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 981539003393 signal recognition particle protein; Provisional; Region: PRK10867 981539003394 SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963 981539003395 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 981539003396 P loop; other site 981539003397 GTP binding site [chemical binding]; other site 981539003398 Signal peptide binding domain; Region: SRP_SPB; pfam02978 981539003399 Helix-turn-helix domain; Region: HTH_18; pfam12833 981539003400 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 981539003401 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 981539003402 Walker A/P-loop; other site 981539003403 ATP binding site [chemical binding]; other site 981539003404 Q-loop/lid; other site 981539003405 ABC transporter signature motif; other site 981539003406 Walker B; other site 981539003407 D-loop; other site 981539003408 H-loop/switch region; other site 981539003409 site-specific tyrosine recombinase XerS; Reviewed; Region: xerS; PRK05084 981539003410 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 981539003411 active site 981539003412 DNA binding site [nucleotide binding] 981539003413 Int/Topo IB signature motif; other site 981539003414 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 981539003415 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 981539003416 non-specific DNA binding site [nucleotide binding]; other site 981539003417 salt bridge; other site 981539003418 sequence-specific DNA binding site [nucleotide binding]; other site 981539003419 Predicted transcriptional regulator [Transcription]; Region: COG2932 981539003420 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 981539003421 Catalytic site [active] 981539003422 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 981539003423 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 981539003424 ATP binding site [chemical binding]; other site 981539003425 G-X-G motif; other site 981539003426 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 981539003427 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 981539003428 active site 981539003429 phosphorylation site [posttranslational modification] 981539003430 intermolecular recognition site; other site 981539003431 dimerization interface [polypeptide binding]; other site 981539003432 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 981539003433 DNA binding site [nucleotide binding] 981539003434 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 981539003435 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 981539003436 Walker A/P-loop; other site 981539003437 ATP binding site [chemical binding]; other site 981539003438 Q-loop/lid; other site 981539003439 ABC transporter signature motif; other site 981539003440 Walker B; other site 981539003441 D-loop; other site 981539003442 H-loop/switch region; other site 981539003443 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 981539003444 tRNA (uracil-5-)-methyltransferase Gid; Reviewed; Region: PRK05335 981539003445 Glucose inhibited division protein A; Region: GIDA; pfam01134 981539003446 Protein of unknown function (DUF3307); Region: DUF3307; pfam11750 981539003447 DNA topoisomerase I; Validated; Region: PRK05582 981539003448 TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I. Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363 981539003449 active site 981539003450 interdomain interaction site; other site 981539003451 putative metal-binding site [ion binding]; other site 981539003452 nucleotide binding site [chemical binding]; other site 981539003453 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 981539003454 domain I; other site 981539003455 DNA binding groove [nucleotide binding] 981539003456 phosphate binding site [ion binding]; other site 981539003457 domain II; other site 981539003458 domain III; other site 981539003459 nucleotide binding site [chemical binding]; other site 981539003460 catalytic site [active] 981539003461 domain IV; other site 981539003462 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 981539003463 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 981539003464 DNA recombination-mediator protein A; Region: DNA_processg_A; pfam02481 981539003465 DNA protecting protein DprA; Region: dprA; TIGR00732 981539003466 maltose O-acetyltransferase; Provisional; Region: PRK10092 981539003467 Maltose O-acetyltransferase (MAT) and Galactoside O-acetyltransferase (GAT): MAT and GAT catalyze the CoA-dependent acetylation of the 6-hydroxyl group of their respective sugar substrates. MAT acetylates maltose and glucose exclusively at the C6...; Region: LbH_MAT_GAT; cd03357 981539003468 active site 981539003469 substrate binding site [chemical binding]; other site 981539003470 trimer interface [polypeptide binding]; other site 981539003471 CoA binding site [chemical binding]; other site 981539003472 bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182 981539003473 RNA/DNA hybrid binding site [nucleotide binding]; other site 981539003474 active site 981539003475 GTPase YlqF; Reviewed; Region: rbgA; PRK09563 981539003476 Circularly permuted YlqF GTPase; Region: YlqF; cd01856 981539003477 GTP/Mg2+ binding site [chemical binding]; other site 981539003478 G4 box; other site 981539003479 G5 box; other site 981539003480 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 981539003481 G1 box; other site 981539003482 G1 box; other site 981539003483 GTP/Mg2+ binding site [chemical binding]; other site 981539003484 Switch I region; other site 981539003485 G2 box; other site 981539003486 G2 box; other site 981539003487 G3 box; other site 981539003488 G3 box; other site 981539003489 Switch II region; other site 981539003490 Switch II region; other site 981539003491 G5 box; other site 981539003492 Protein of unknown function (DUF4231); Region: DUF4231; pfam14015 981539003493 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 981539003494 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 981539003495 dimer interface [polypeptide binding]; other site 981539003496 phosphorylation site [posttranslational modification] 981539003497 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 981539003498 ATP binding site [chemical binding]; other site 981539003499 Mg2+ binding site [ion binding]; other site 981539003500 G-X-G motif; other site 981539003501 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 981539003502 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 981539003503 active site 981539003504 phosphorylation site [posttranslational modification] 981539003505 intermolecular recognition site; other site 981539003506 dimerization interface [polypeptide binding]; other site 981539003507 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 981539003508 DNA binding site [nucleotide binding] 981539003509 lantibiotic protection ABC transporter permease subunit, MutG family; Region: lanti_perm_MutG; TIGR03733 981539003510 lantibiotic protection ABC transporter permease subunit, MutE/EpiE family; Region: lanti_perm_MutE; TIGR03732 981539003511 ATP-binding cassette domain of the bacitracin-resistance transporter; Region: ABC_BcrA_bacitracin_resist; cd03268 981539003512 gallidermin-class lantibiotic protection ABC transporter, ATP-binding subunit; Region: galliderm_ABC; TIGR03740 981539003513 Walker A/P-loop; other site 981539003514 ATP binding site [chemical binding]; other site 981539003515 Q-loop/lid; other site 981539003516 ABC transporter signature motif; other site 981539003517 Walker B; other site 981539003518 D-loop; other site 981539003519 H-loop/switch region; other site 981539003520 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 981539003521 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 981539003522 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 981539003523 ABC transporter; Region: ABC_tran_2; pfam12848 981539003524 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 981539003525 Predicted membrane protein [Function unknown]; Region: COG4720 981539003526 Pyridoxal kinase plays a key role in the synthesis of the active coenzyme pyridoxal-5'-phosphate (PLP), by catalyzing the phosphorylation of the precursor vitamin B6 in the presence of Zn2+ and ATP. Mammals are unable to synthesize PLP de novo and...; Region: pyridoxal_pyridoxamine_kinase; cd01173 981539003527 dimer interface [polypeptide binding]; other site 981539003528 pyridoxal binding site [chemical binding]; other site 981539003529 ATP binding site [chemical binding]; other site 981539003530 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 981539003531 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 981539003532 DNA-binding site [nucleotide binding]; DNA binding site 981539003533 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 981539003534 pyridoxal 5'-phosphate binding site [chemical binding]; other site 981539003535 homodimer interface [polypeptide binding]; other site 981539003536 catalytic residue [active] 981539003537 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 981539003538 Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950 981539003539 dimer interface [polypeptide binding]; other site 981539003540 active site 981539003541 catalytic residue [active] 981539003542 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 981539003543 aspartate-semialdehyde dehydrogenase; Provisional; Region: PRK14874 981539003544 Phospholipase_D-nuclease N-terminal; Region: PLDc_N; pfam13396 981539003545 Phosphatidylserine/phosphatidylglycerophosphate/car diolipin synthases and related enzymes [Lipid metabolism]; Region: Cls; COG1502 981539003546 Putative catalytic domain, repeat 1, of Streptococcus mutans uncharacterized protein SMU_988 and similar proteins; Region: PLDc_SMU_988_like_1; cd09154 981539003547 putative active site [active] 981539003548 catalytic site [active] 981539003549 Putative catalytic domain, repeat 2, of Streptococcus mutans uncharacterized protein SMU_988 and similar proteins; Region: PLDc_SMU_988_like_2; cd09160 981539003550 putative active site [active] 981539003551 catalytic site [active] 981539003552 formate--tetrahydrofolate ligase; Provisional; Region: PRK13505 981539003553 Formyltetrahydrofolate synthetase (FTHFS) catalyzes the ATP-dependent activation of formate ion via its addition to the N10 position of tetrahydrofolate. FTHFS is a highly expressed key enzyme in both the Wood-Ljungdahl pathway of autotrophic CO2...; Region: FTHFS; cd00477 981539003554 Potassium binding sites [ion binding]; other site 981539003555 Cesium cation binding sites [ion binding]; other site 981539003556 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 981539003557 DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179 981539003558 Ligand binding site; other site 981539003559 Putative Catalytic site; other site 981539003560 DXD motif; other site 981539003561 GtrA-like protein; Region: GtrA; pfam04138 981539003562 Domain of unknown function (DUF4353); Region: DUF4353; pfam14262 981539003563 Predicted periplasmic protein (DUF2233); Region: DUF2233; pfam09992 981539003564 phosphopantothenate--cysteine ligase; Validated; Region: PRK06732 981539003565 phosphopantothenoylcysteine decarboxylase; Validated; Region: PRK07313 981539003566 Flavoprotein; Region: Flavoprotein; pfam02441 981539003567 Predicted membrane protein [Function unknown]; Region: COG4684 981539003568 phosphoglucomutase-2-like protein; Provisional; Region: PTZ00150 981539003569 This CD includes PGM2 (phosphoglucomutase 2) and PGM2L1 (phosphoglucomutase 2-like 1). The mammalian PGM2 is thought to be a phosphopentomutase that catalyzes the conversion of the nucleoside breakdown products, ribose-1-phosphate and...; Region: PGM2; cd05799 981539003570 active site 981539003571 substrate binding site [chemical binding]; other site 981539003572 metal binding site [ion binding]; metal-binding site 981539003573 Mn2+ and Fe2+ transporters of the NRAMP family [Inorganic ion transport and metabolism]; Region: MntH; COG1914 981539003574 Predicted secreted protein [Function unknown]; Region: COG4086 981539003575 Protein of unknown function (DUF1002); Region: DUF1002; pfam06207 981539003576 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_1; cd08352 981539003577 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 981539003578 putative metal binding site [ion binding]; other site 981539003579 Sortase A (SrtA) or subfamily-1 sortases are cysteine transpeptidases found in gram-positive bacteria that anchor surface proteins to peptidoglycans of the bacterial cell wall envelope. They do so by catalyzing a transpeptidation reaction in which the...; Region: Sortase_A_1; cd06165 981539003580 active site 981539003581 catalytic site [active] 981539003582 DNA gyrase subunit A; Validated; Region: PRK05560 981539003583 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 981539003584 CAP-like domain; other site 981539003585 active site 981539003586 primary dimer interface [polypeptide binding]; other site 981539003587 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 981539003588 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 981539003589 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 981539003590 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 981539003591 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 981539003592 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 981539003593 L-lactate dehydrogenase; Reviewed; Region: ldh; PRK00066 981539003594 L-2-hydroxyisocapronate dehydrogenases and some bacterial L-lactate dehydrogenases; Region: HicDH_like; cd05291 981539003595 tetramer (dimer of dimers) interface [polypeptide binding]; other site 981539003596 NAD binding site [chemical binding]; other site 981539003597 dimer interface [polypeptide binding]; other site 981539003598 substrate binding site [chemical binding]; other site 981539003599 coenzyme A disulfide reductase; Reviewed; Region: PRK09564 981539003600 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 981539003601 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 981539003602 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 981539003603 HTH-like domain; Region: HTH_21; pfam13276 981539003604 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 981539003605 Integrase core domain; Region: rve; pfam00665 981539003606 Integrase core domain; Region: rve_2; pfam13333 981539003607 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 981539003608 Helix-turn-helix domain; Region: HTH_38; pfam13936 981539003609 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 981539003610 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 981539003611 TM-ABC transporter signature motif; other site 981539003612 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 981539003613 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 981539003614 TM-ABC transporter signature motif; other site 981539003615 ABC-type uncharacterized transport systems, ATPase components [General function prediction only]; Region: COG3845 981539003616 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 981539003617 Walker A/P-loop; other site 981539003618 ATP binding site [chemical binding]; other site 981539003619 Q-loop/lid; other site 981539003620 ABC transporter signature motif; other site 981539003621 Walker B; other site 981539003622 D-loop; other site 981539003623 H-loop/switch region; other site 981539003624 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 981539003625 Uncharacterized ABC-type transport system, periplasmic component/surface lipoprotein [General function prediction only]; Region: Med; COG1744 981539003626 Periplasmic binding domain of basic membrane lipoprotein, PnrA, in Treponema pallidum and its homologs from other bacteria and Archaea; Region: PBP1_BmpA_PnrA_like; cd06354 981539003627 ligand binding site [chemical binding]; other site 981539003628 2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family; Region: DeoC; cd00959 981539003629 intersubunit interface [polypeptide binding]; other site 981539003630 active site 981539003631 catalytic residue [active] 981539003632 Methyltransferase domain; Region: Methyltransf_31; pfam13847 981539003633 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 981539003634 S-adenosylmethionine binding site [chemical binding]; other site 981539003635 pantothenate kinase; Provisional; Region: PRK05439 981539003636 Pantothenate kinase (PanK) catalyzes the phosphorylation of pantothenic acid to form 4'-phosphopantothenic, which is the first of five steps in coenzyme A (CoA) biosynthetic pathway. The reaction carried out by this enzyme is a key regulatory point...; Region: PanK; cd02025 981539003637 ATP-binding site [chemical binding]; other site 981539003638 CoA-binding site [chemical binding]; other site 981539003639 Mg2+-binding site [ion binding]; other site 981539003640 30S ribosomal protein S20; Reviewed; Region: rpsT; PRK00239 981539003641 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 981539003642 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 981539003643 dimer interface [polypeptide binding]; other site 981539003644 phosphorylation site [posttranslational modification] 981539003645 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 981539003646 ATP binding site [chemical binding]; other site 981539003647 Mg2+ binding site [ion binding]; other site 981539003648 G-X-G motif; other site 981539003649 heavy metal response regulator; Region: cztR_silR_copR; TIGR01387 981539003650 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 981539003651 active site 981539003652 phosphorylation site [posttranslational modification] 981539003653 intermolecular recognition site; other site 981539003654 dimerization interface [polypeptide binding]; other site 981539003655 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 981539003656 DNA binding site [nucleotide binding] 981539003657 Aminopeptidase N [Amino acid transport and metabolism]; Region: PepN; COG0308 981539003658 Peptidase M1 Aminopeptidase N family incudes tricorn interacting factor F3, Endoplasmic reticulum aminopeptidase 1 (ERAP1), Aminopeptidase Q (APQ); Region: M1_APN_2; cd09601 981539003659 Zn binding site [ion binding]; other site 981539003660 phosphate transport system regulatory protein PhoU; Region: phoU_full; TIGR02135 981539003661 PhoU domain; Region: PhoU; pfam01895 981539003662 PhoU domain; Region: PhoU; pfam01895 981539003663 phosphate transporter ATP-binding protein; Provisional; Region: PRK14239 981539003664 ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260 981539003665 Walker A/P-loop; other site 981539003666 ATP binding site [chemical binding]; other site 981539003667 Q-loop/lid; other site 981539003668 ABC transporter signature motif; other site 981539003669 Walker B; other site 981539003670 D-loop; other site 981539003671 H-loop/switch region; other site 981539003672 phosphate transporter ATP-binding protein; Provisional; Region: PRK14237 981539003673 ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260 981539003674 Walker A/P-loop; other site 981539003675 ATP binding site [chemical binding]; other site 981539003676 Q-loop/lid; other site 981539003677 ABC transporter signature motif; other site 981539003678 Walker B; other site 981539003679 D-loop; other site 981539003680 H-loop/switch region; other site 981539003681 ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstA; COG0581 981539003682 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 981539003683 dimer interface [polypeptide binding]; other site 981539003684 conserved gate region; other site 981539003685 putative PBP binding loops; other site 981539003686 ABC-ATPase subunit interface; other site 981539003687 ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstC; COG0573 981539003688 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 981539003689 dimer interface [polypeptide binding]; other site 981539003690 conserved gate region; other site 981539003691 putative PBP binding loops; other site 981539003692 ABC-ATPase subunit interface; other site 981539003693 truncated phosphate transport system substrate-binding protein 981539003694 truncated phosphate transport system substrate-binding protein 981539003695 rRNA (cytosine-C(5)-)-methyltransferase RsmF; Reviewed; Region: yebU; PRK11933 981539003696 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 981539003697 S-adenosylmethionine binding site [chemical binding]; other site 981539003698 pre-rRNA processing and ribosome biogenesis; Region: Nol1_Nop2_Fmu_2; pfam13636 981539003699 glutathione reductase; Validated; Region: PRK06116 981539003700 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 981539003701 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 981539003702 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 981539003703 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 981539003704 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 981539003705 catalytic residues [active] 981539003706 Uncharacterized conserved protein [Function unknown]; Region: COG1359 981539003707 Predicted divalent heavy-metal cations transporter [Inorganic ion transport and metabolism]; Region: COG0428 981539003708 ZIP Zinc transporter; Region: Zip; pfam02535 981539003709 Methyladenine glycosylase; Region: Adenine_glyco; pfam03352 981539003710 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 981539003711 Inositol-monophosphatase-like domains. This family of phosphatases is dependent on bivalent metal ions such as Mg++, and many members are inhibited by Li+ (which is thought to displace a bivalent ion in the active site). Substrates include fructose-1; Region: IMPase_like; cd01637 981539003712 active site 981539003713 hypothetical protein; Provisional; Region: PRK04387 981539003714 Arsenate Reductase (ArsC) family, Spx subfamily; Spx is a unique RNA polymerase (RNAP)-binding protein present in bacilli and some mollicutes. It inhibits transcription by binding to the C-terminal domain of the alpha subunit of RNAP, disrupting complex...; Region: ArsC_Spx; cd03032 981539003715 ArsC family; Region: ArsC; pfam03960 981539003716 putative catalytic residues [active] 981539003717 thiol/disulfide switch; other site 981539003718 bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627 981539003719 FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064 981539003720 active site 981539003721 Riboflavin kinase; Region: Flavokinase; pfam01687 981539003722 tRNA pseudouridine synthase B; Provisional; Region: truB; PRK02484 981539003723 Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573 981539003724 RNA binding site [nucleotide binding]; other site 981539003725 active site 981539003726 tRNA Pseudouridine synthase II, C terminal; Region: TruB_C; pfam09142 981539003727 Uncharacterized conserved protein [Function unknown]; Region: COG2461 981539003728 Family of unknown function (DUF438); Region: DUF438; pfam04282 981539003729 Domain of unknown function (DUF1858); Region: DUF1858; pfam08984 981539003730 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 981539003731 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 981539003732 Coenzyme A binding pocket [chemical binding]; other site 981539003733 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4487 981539003734 Uncharacterized protein conserved in bacteria (DUF2130); Region: DUF2130; pfam09903 981539003735 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 981539003736 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 981539003737 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 981539003738 Walker A/P-loop; other site 981539003739 ATP binding site [chemical binding]; other site 981539003740 Q-loop/lid; other site 981539003741 ABC transporter signature motif; other site 981539003742 Walker B; other site 981539003743 D-loop; other site 981539003744 H-loop/switch region; other site 981539003745 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 981539003746 cobalt transport protein ATP-binding subunit; Region: cbiO; TIGR01166 981539003747 Walker A/P-loop; other site 981539003748 ATP binding site [chemical binding]; other site 981539003749 Q-loop/lid; other site 981539003750 ABC transporter signature motif; other site 981539003751 Walker B; other site 981539003752 D-loop; other site 981539003753 H-loop/switch region; other site 981539003754 ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619 981539003755 Hypothetical bacterial integral membrane protein (Trep_Strep); Region: Trep_Strep; pfam09605 981539003756 truncated ABC transport system ATP-binding protein 981539003757 truncated ABC transport system ATP-binding protein 981539003758 ABC-type transport system involved in cytochrome bd biosynthesis, ATPase and permease components [Energy production and conversion / Posttranslational modification, protein turnover, chaperones]; Region: CydD; COG4988 981539003759 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 981539003760 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 981539003761 Walker A/P-loop; other site 981539003762 ATP binding site [chemical binding]; other site 981539003763 Q-loop/lid; other site 981539003764 ABC transporter signature motif; other site 981539003765 Walker B; other site 981539003766 D-loop; other site 981539003767 H-loop/switch region; other site 981539003768 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 981539003769 FtsX-like permease family; Region: FtsX; pfam02687 981539003770 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 981539003771 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 981539003772 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 981539003773 Walker A/P-loop; other site 981539003774 ATP binding site [chemical binding]; other site 981539003775 Q-loop/lid; other site 981539003776 ABC transporter signature motif; other site 981539003777 Walker B; other site 981539003778 D-loop; other site 981539003779 H-loop/switch region; other site 981539003780 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 981539003781 truncated thiol peroxidase, atypical 2-Cys peroxiredoxin 981539003782 truncated thiol peroxidase, atypical 2-Cys peroxiredoxin 981539003783 Kynurenine formamidase [Amino acid transport and metabolism]; Region: COG1878 981539003784 O-acetylhomoserine sulfhydrylase [Amino acid transport and metabolism]; Region: MET17; COG2873 981539003785 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 981539003786 homodimer interface [polypeptide binding]; other site 981539003787 substrate-cofactor binding pocket; other site 981539003788 pyridoxal 5'-phosphate binding site [chemical binding]; other site 981539003789 catalytic residue [active] 981539003790 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 981539003791 thiamine phosphate binding site [chemical binding]; other site 981539003792 active site 981539003793 pyrophosphate binding site [ion binding]; other site 981539003794 4-methyl-5-beta-hydroxyethylthiazole (Thz) kinase catalyzes the phosphorylation of the hydroxylgroup of Thz. A reaction that allows cells to recycle Thz into the thiamine biosynthesis pathway, as an alternative to its synthesis from cysteine, tyrosine...; Region: THZ_kinase; cd01170 981539003795 substrate binding site [chemical binding]; other site 981539003796 multimerization interface [polypeptide binding]; other site 981539003797 ATP binding site [chemical binding]; other site 981539003798 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 981539003799 dimer interface [polypeptide binding]; other site 981539003800 substrate binding site [chemical binding]; other site 981539003801 ATP binding site [chemical binding]; other site 981539003802 TENA/THI-4/PQQC family; Region: TENA_THI-4; cl15243 981539003803 Predicted hydrolase (HAD superfamily) [General function prediction only]; Region: COG1011 981539003804 ?-D-glucose-1-phosphatase; Provisional; Region: PRK09456 981539003805 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 981539003806 S-adenosylmethionine binding site [chemical binding]; other site 981539003807 Thiamine-precursor transporter protein (ThiW); Region: ThiW; pfam09512 981539003808 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 981539003809 non-specific DNA binding site [nucleotide binding]; other site 981539003810 salt bridge; other site 981539003811 sequence-specific DNA binding site [nucleotide binding]; other site 981539003812 transcriptional activator, Rgg/GadR/MutR family, C-terminal domain; Region: RGG_Cterm; TIGR01716 981539003813 ATP-dependent DNA helicase PcrA; Region: pcrA; TIGR01073 981539003814 Part of AAA domain; Region: AAA_19; pfam13245 981539003815 Family description; Region: UvrD_C_2; pfam13538 981539003816 Glutamine Amidotransferase (GATase_I) involved in pyridoxine biosynthesis; Region: GATase1_PB; cd01749 981539003817 predicted active site [active] 981539003818 catalytic triad [active] 981539003819 pyridoxal 5'-phosphate synthase, synthase subunit Pdx1; Region: TIGR00343 981539003820 PdxS is a subunit of the pyridoxal 5'-phosphate (PLP) synthase, an important enzyme in deoxyxylulose 5-phosphate (DXP)-independent pathway for de novo biosynthesis of PLP, present in some eubacteria, in archaea, fungi, plants, plasmodia, and some...; Region: pdxS; cd04727 981539003821 active site 981539003822 multimer interface [polypeptide binding]; other site 981539003823 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 981539003824 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 981539003825 DNA-binding site [nucleotide binding]; DNA binding site 981539003826 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 981539003827 pyridoxal 5'-phosphate binding site [chemical binding]; other site 981539003828 homodimer interface [polypeptide binding]; other site 981539003829 catalytic residue [active] 981539003830 Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115 981539003831 amino acid carrier protein; Region: agcS; TIGR00835 981539003832 Rrf2 family protein; Region: rrf2_super; TIGR00738 981539003833 Transcriptional regulator; Region: Rrf2; pfam02082 981539003834 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 981539003835 NADH(P)-binding; Region: NAD_binding_10; pfam13460 981539003836 NAD(P) binding site [chemical binding]; other site 981539003837 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 981539003838 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cl17915 981539003839 GBS Bsp-like repeat; Region: GBS_Bsp-like; pfam08481 981539003840 GBS Bsp-like repeat; Region: GBS_Bsp-like; pfam08481 981539003841 GBS Bsp-like repeat; Region: GBS_Bsp-like; pfam08481 981539003842 GBS Bsp-like repeat; Region: GBS_Bsp-like; pfam08481 981539003843 GBS Bsp-like repeat; Region: GBS_Bsp-like; pfam08481 981539003844 GBS Bsp-like repeat; Region: GBS_Bsp-like; pfam08481 981539003845 Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various bacteriocins (mostly non-lantibiotic); Region: Peptidase_C39_like; cl00296 981539003846 putative active site [active] 981539003847 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 981539003848 SnoaL-like domain; Region: SnoaL_4; pfam13577 981539003849 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 981539003850 Major Facilitator Superfamily; Region: MFS_1; pfam07690 981539003851 putative substrate translocation pore; other site 981539003852 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 981539003853 Glycosyl hydrolase family 1; Region: Glyco_hydro_1; cl01046 981539003854 beta-galactosidase; Region: BGL; TIGR03356 981539003855 NnaC (CMP-NeuNAc synthetase) _like subfamily of SGNH_hydrolases, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its...; Region: NnaC_like; cd01841 981539003856 active site 981539003857 catalytic triad [active] 981539003858 oxyanion hole [active] 981539003859 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 981539003860 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 981539003861 active site 981539003862 motif I; other site 981539003863 motif II; other site 981539003864 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 981539003865 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cl17915 981539003866 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 981539003867 active site 981539003868 motif I; other site 981539003869 motif II; other site 981539003870 Ras GTPase Activating Domain; Region: RasGAP; cl02569 981539003871 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 981539003872 maltose O-acetyltransferase; Provisional; Region: PRK10092 981539003873 Maltose O-acetyltransferase (MAT) and Galactoside O-acetyltransferase (GAT): MAT and GAT catalyze the CoA-dependent acetylation of the 6-hydroxyl group of their respective sugar substrates. MAT acetylates maltose and glucose exclusively at the C6...; Region: LbH_MAT_GAT; cd03357 981539003874 active site 981539003875 substrate binding site [chemical binding]; other site 981539003876 trimer interface [polypeptide binding]; other site 981539003877 CoA binding site [chemical binding]; other site 981539003878 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 981539003879 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 981539003880 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 981539003881 short chain dehydrogenase; Provisional; Region: PRK06180 981539003882 17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374 981539003883 NADP binding site [chemical binding]; other site 981539003884 active site 981539003885 steroid binding site; other site 981539003886 Uncharacterized conserved protein [Function unknown]; Region: COG3589 981539003887 Bacterial protein of unknown function (DUF871); Region: DUF871; pfam05913 981539003888 cellobiose phosphotransferase system IIC component; Reviewed; Region: celD; PRK09592 981539003889 Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455 981539003890 PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_lac; cd00215 981539003891 methionine cluster; other site 981539003892 active site 981539003893 phosphorylation site [posttranslational modification] 981539003894 metal binding site [ion binding]; metal-binding site 981539003895 Transcriptional antiterminator [Transcription]; Region: BglG; COG3711 981539003896 HTH domain; Region: HTH_11; pfam08279 981539003897 Mga helix-turn-helix domain; Region: Mga; pfam05043 981539003898 PRD domain; Region: PRD; pfam00874 981539003899 PRD domain; Region: PRD; pfam00874 981539003900 PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568 981539003901 active site 981539003902 P-loop; other site 981539003903 phosphorylation site [posttranslational modification] 981539003904 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 981539003905 active site 981539003906 phosphorylation site [posttranslational modification] 981539003907 cellobiose phosphotransferase system IIB component; Reviewed; Region: celB; PRK09590 981539003908 active site 981539003909 P-loop; other site 981539003910 phosphorylation site [posttranslational modification] 981539003911 Protein of unknown function (DUF669); Region: DUF669; pfam05037 981539003912 Uncharacterized conserved protein [Function unknown]; Region: COG4095 981539003913 6-phospho-beta-glucosidase; Reviewed; Region: celA; PRK09589 981539003914 beta-galactosidase; Region: BGL; TIGR03356 981539003915 Predicted unusual protein kinase [General function prediction only]; Region: AarF; COG0661 981539003916 ABC1 family; Region: ABC1; cl17513 981539003917 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120 981539003918 active site 981539003919 ATP binding site [chemical binding]; other site 981539003920 ABC1 family; Region: ABC1; cl17513 981539003921 Uncharacterized conserved protein [Function unknown]; Region: COG3937 981539003922 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 981539003923 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 981539003924 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 981539003925 PTS system, beta-glucoside-specific IIABC component; Region: PTS-II-ABC-beta; TIGR01995 981539003926 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 981539003927 active site turn [active] 981539003928 phosphorylation site [posttranslational modification] 981539003929 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 981539003930 PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_glc; cd00210 981539003931 HPr interaction site; other site 981539003932 glycerol kinase (GK) interaction site [polypeptide binding]; other site 981539003933 active site 981539003934 phosphorylation site [posttranslational modification] 981539003935 transcriptional antiterminator BglG; Provisional; Region: PRK09772 981539003936 CAT RNA binding domain; Region: CAT_RBD; smart01061 981539003937 PRD domain; Region: PRD; pfam00874 981539003938 PRD domain; Region: PRD; pfam00874 981539003939 ClC chloride channel EriC. This domain is found in the EriC chloride transporters that mediate the extreme acid resistance response in eubacteria and archaea. This response allows bacteria to survive in the acidic environments by decarboxylation-linked...; Region: EriC; cd01031 981539003940 Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038 981539003941 Cl- selectivity filter; other site 981539003942 Cl- binding residues [ion binding]; other site 981539003943 pore gating glutamate residue; other site 981539003944 dimer interface [polypeptide binding]; other site 981539003945 H+/Cl- coupling transport residue; other site 981539003946 TrkA-C domain; Region: TrkA_C; pfam02080 981539003947 Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687 981539003948 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 981539003949 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 981539003950 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 981539003951 dimer interface [polypeptide binding]; other site 981539003952 conserved gate region; other site 981539003953 putative PBP binding loops; other site 981539003954 ABC-ATPase subunit interface; other site 981539003955 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 981539003956 dimer interface [polypeptide binding]; other site 981539003957 conserved gate region; other site 981539003958 putative PBP binding loops; other site 981539003959 ABC-ATPase subunit interface; other site 981539003960 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 981539003961 ATP-binding cassette domain of the polyamine transporter; Region: ABC_PotA_N; cd03300 981539003962 Walker A/P-loop; other site 981539003963 ATP binding site [chemical binding]; other site 981539003964 Q-loop/lid; other site 981539003965 ABC transporter signature motif; other site 981539003966 Walker B; other site 981539003967 D-loop; other site 981539003968 H-loop/switch region; other site 981539003969 TOBE domain; Region: TOBE_2; pfam08402 981539003970 UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK13905 981539003971 FAD binding domain; Region: FAD_binding_4; pfam01565 981539003972 UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873 981539003973 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483 981539003974 catalytic center binding site [active] 981539003975 ATP binding site [chemical binding]; other site 981539003976 Dihydroneopterin aldolase (DHNA) and 7,8-dihydroneopterin triphosphate epimerase domain (DHNTPE); these enzymes have been designated folB and folX, respectively. Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and...; Region: DHNA_DHNTPE; cd00534 981539003977 homooctamer interface [polypeptide binding]; other site 981539003978 active site 981539003979 dihydropteroate synthase; Region: DHPS; TIGR01496 981539003980 DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739 981539003981 substrate binding pocket [chemical binding]; other site 981539003982 dimer interface [polypeptide binding]; other site 981539003983 inhibitor binding site; inhibition site 981539003984 GTP cyclohydrolase I (GTP-CH-I) catalyzes the conversion of GTP into dihydroneopterin triphosphate. The enzyme product is the precursor of tetrahydrofolate in eubacteria, fungi, and plants and of the folate analogs in methanogenic bacteria. In...; Region: GTP_cyclohydro1; cd00642 981539003985 homodecamer interface [polypeptide binding]; other site 981539003986 GTP cyclohydrolase I; Provisional; Region: PLN03044 981539003987 active site 981539003988 putative catalytic site residues [active] 981539003989 zinc binding site [ion binding]; other site 981539003990 GTP-CH-I/GFRP interaction surface; other site 981539003991 Folylpolyglutamate synthase [Coenzyme metabolism]; Region: FolC; COG0285 981539003992 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 981539003993 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 981539003994 Bacterial periplasmic substrate-binding proteins; Region: PBPb; smart00062 981539003995 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 981539003996 substrate binding pocket [chemical binding]; other site 981539003997 membrane-bound complex binding site; other site 981539003998 hinge residues; other site 981539003999 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 981539004000 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 981539004001 Walker A/P-loop; other site 981539004002 ATP binding site [chemical binding]; other site 981539004003 Q-loop/lid; other site 981539004004 ABC transporter signature motif; other site 981539004005 Walker B; other site 981539004006 D-loop; other site 981539004007 H-loop/switch region; other site 981539004008 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 981539004009 dimer interface [polypeptide binding]; other site 981539004010 conserved gate region; other site 981539004011 ABC-ATPase subunit interface; other site 981539004012 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 981539004013 dimer interface [polypeptide binding]; other site 981539004014 conserved gate region; other site 981539004015 putative PBP binding loops; other site 981539004016 ABC-ATPase subunit interface; other site 981539004017 aminodeoxychorismate synthase; Provisional; Region: PRK07508 981539004018 chorismate binding enzyme; Region: Chorismate_bind; cl10555 981539004019 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 981539004020 Aminotransferase class IV; Region: Aminotran_4; pfam01063 981539004021 substrate-cofactor binding pocket; other site 981539004022 pyridoxal 5'-phosphate binding site [chemical binding]; other site 981539004023 catalytic residue [active] 981539004024 rarD protein; Region: rarD; TIGR00688 981539004025 EamA-like transporter family; Region: EamA; pfam00892 981539004026 homoserine kinase; Provisional; Region: PRK01212 981539004027 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 981539004028 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 981539004029 homoserine dehydrogenase; Provisional; Region: PRK06349 981539004030 Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447 981539004031 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 981539004032 ACT_HSDH_Hom CD includes the C-terminal ACT domain of the NAD(P)H-dependent, homoserine dehydrogenase (HSDH) and related domains; Region: ACT_HSDH-Hom; cd04881 981539004033 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 981539004034 Putative catalytic NodB homology domain of PgaB, IcaB, and similar proteins which consist of a deformed (beta/alpha)8 barrel fold with 5- or 6-strands; Region: CE4_NodB_like_5s_6s; cd10918 981539004035 putative active site [active] 981539004036 putative metal binding site [ion binding]; other site 981539004037 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3666 981539004038 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 981539004039 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 981539004040 probable dihydroxyacetone kinase regulator; Region: DHAK_reg; TIGR02366 981539004041 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 981539004042 Transcriptional regulator C-terminal region; Region: TetR_C_8; pfam14278 981539004043 Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387 981539004044 core dimer interface [polypeptide binding]; other site 981539004045 L10 interface [polypeptide binding]; other site 981539004046 L11 interface [polypeptide binding]; other site 981539004047 putative EF-Tu interaction site [polypeptide binding]; other site 981539004048 putative EF-G interaction site [polypeptide binding]; other site 981539004049 Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797 981539004050 23S rRNA interface [nucleotide binding]; other site 981539004051 Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site 981539004052 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 981539004053 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 981539004054 Walker A motif; other site 981539004055 ATP binding site [chemical binding]; other site 981539004056 ATPases of the AAA+ class [Posttranslational modification, protein turnover, chaperones]; Region: SpoVK; COG0464 981539004057 Walker B motif; other site 981539004058 arginine finger; other site 981539004059 UvrB/uvrC motif; Region: UVR; pfam02151 981539004060 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 981539004061 Walker A motif; other site 981539004062 ATP binding site [chemical binding]; other site 981539004063 Walker B motif; other site 981539004064 arginine finger; other site 981539004065 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 981539004066 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 981539004067 endonuclease III; Region: ENDO3c; smart00478 981539004068 minor groove reading motif; other site 981539004069 helix-hairpin-helix signature motif; other site 981539004070 substrate binding pocket [chemical binding]; other site 981539004071 active site 981539004072 Protein of unknown function (DUF1275); Region: DUF1275; pfam06912 981539004073 homocysteine methyltransferase; Provisional; Region: mmuM; PRK09485 981539004074 Homocysteine S-methyltransferase; Region: S-methyl_trans; pfam02574 981539004075 S-methylmethionine transporter; Provisional; Region: PRK11387 981539004076 YihA (EngB) GTPase family; Region: YihA_EngB; cd01876 981539004077 G1 box; other site 981539004078 GTP/Mg2+ binding site [chemical binding]; other site 981539004079 Switch I region; other site 981539004080 G2 box; other site 981539004081 G3 box; other site 981539004082 Switch II region; other site 981539004083 G4 box; other site 981539004084 G5 box; other site 981539004085 ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342 981539004086 ClpX C4-type zinc finger; Region: zf-C4_ClpX; pfam06689 981539004087 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 981539004088 Walker A motif; other site 981539004089 ATP binding site [chemical binding]; other site 981539004090 Walker B motif; other site 981539004091 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 981539004092 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 981539004093 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cd00209 981539004094 folate binding site [chemical binding]; other site 981539004095 NADP+ binding site [chemical binding]; other site 981539004096 thymidylate synthase; Reviewed; Region: thyA; PRK01827 981539004097 Thymidylate synthase and pyrimidine hydroxymethylase: Thymidylate synthase (TS) and deoxycytidylate hydroxymethylase (dCMP-HMase) are homologs that catalyze analogous alkylation of C5 of pyrimidine nucleotides. Both enzymes are involved in the...; Region: TS_Pyrimidine_HMase; cd00351 981539004098 dimerization interface [polypeptide binding]; other site 981539004099 active site 981539004100 "initiating" condensing enzymes are a subclass of decarboxylating condensing enzymes, including beta-ketoacyl [ACP] synthase, type III and polyketide synthases, type III, which include chalcone synthase and related enzymes. They are...; Region: init_cond_enzymes; cd00827 981539004101 3-hydroxy-3-methylglutaryl CoA synthase, prokaryotic clade; Region: HMG-CoA-S_prok; TIGR01835 981539004102 dimer interface [polypeptide binding]; other site 981539004103 active site 981539004104 Class II hydroxymethylglutaryl-coenzyme A (HMG-CoA) reductase (HMGR); Region: HMG-CoA_reductase_classII; cd00644 981539004105 homodimer interface [polypeptide binding]; other site 981539004106 catalytic residues [active] 981539004107 NAD binding site [chemical binding]; other site 981539004108 substrate binding pocket [chemical binding]; other site 981539004109 flexible flap; other site 981539004110 Domain of unknown function (DUF1836); Region: DUF1836; pfam08876 981539004111 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 981539004112 Predicted membrane protein, hemolysin III homolog [General function prediction only]; Region: COG1272 981539004113 channel protein, hemolysin III family; Region: hlyIII; TIGR01065 981539004114 isopentenyl pyrophosphate isomerase; Provisional; Region: PRK05437 981539004115 Isopentenyl-diphosphate:dimethylallyl diphosphate isomerase type 2 (IDI-2) FMN-binding domain. Two types of IDIs have been characterized at present. The long known IDI-1 is only dependent on divalent metals for activity, whereas IDI-2 requires a metal; Region: IDI-2_FMN; cd02811 981539004116 homotetramer interface [polypeptide binding]; other site 981539004117 FMN binding site [chemical binding]; other site 981539004118 homodimer contacts [polypeptide binding]; other site 981539004119 putative active site [active] 981539004120 putative substrate binding site [chemical binding]; other site 981539004121 Mevalonate kinase [Lipid metabolism]; Region: ERG12; COG1577 981539004122 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 981539004123 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 981539004124 diphosphomevalonate decarboxylase; Region: PLN02407 981539004125 diphosphomevalonate decarboxylase; Region: mevDPdecarb; TIGR01240 981539004126 mevalonate kinase; Region: mevalon_kin; TIGR00549 981539004127 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 981539004128 Predicted glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: ECM4; COG0435 981539004129 C-terminal, alpha helical domain of Class Omega-like Glutathione S-transferases; Region: GST_C_Omega_like; cd03190 981539004130 putative dimer interface [polypeptide binding]; other site 981539004131 N-terminal domain interface [polypeptide binding]; other site 981539004132 putative substrate binding pocket (H-site) [chemical binding]; other site 981539004133 Predicted glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: ECM4; COG0435 981539004134 Glutathione S-transferase, N-terminal domain; Region: GST_N_2; pfam13409 981539004135 C-terminal, alpha helical domain of Class Omega-like Glutathione S-transferases; Region: GST_C_Omega_like; cd03190 981539004136 putative dimer interface [polypeptide binding]; other site 981539004137 N-terminal domain interface [polypeptide binding]; other site 981539004138 putative substrate binding pocket (H-site) [chemical binding]; other site 981539004139 Acetyltransferase (GNAT) domain; Region: Acetyltransf_7; pfam13508 981539004140 Coenzyme A binding pocket [chemical binding]; other site 981539004141 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 981539004142 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 981539004143 substrate binding pocket [chemical binding]; other site 981539004144 membrane-bound complex binding site; other site 981539004145 hinge residues; other site 981539004146 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 981539004147 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 981539004148 Walker A/P-loop; other site 981539004149 ATP binding site [chemical binding]; other site 981539004150 Q-loop/lid; other site 981539004151 ABC transporter signature motif; other site 981539004152 Walker B; other site 981539004153 D-loop; other site 981539004154 H-loop/switch region; other site 981539004155 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 981539004156 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 981539004157 dimer interface [polypeptide binding]; other site 981539004158 conserved gate region; other site 981539004159 putative PBP binding loops; other site 981539004160 ABC-ATPase subunit interface; other site 981539004161 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 981539004162 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 981539004163 dimer interface [polypeptide binding]; other site 981539004164 conserved gate region; other site 981539004165 putative PBP binding loops; other site 981539004166 ABC-ATPase subunit interface; other site 981539004167 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 981539004168 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 981539004169 substrate binding pocket [chemical binding]; other site 981539004170 membrane-bound complex binding site; other site 981539004171 hinge residues; other site 981539004172 The URO-D _like protein superfamily includes bacterial and eukaryotic uroporphyrinogen decarboxylases (URO-D), coenzyme M methyltransferases and other putative bacterial methyltransferases. Uroporphyrinogen decarboxylase (URO-D) decarboxylates the four...; Region: URO-D_like; cd03465 981539004173 Transcriptional regulator [Transcription]; Region: LysR; COG0583 981539004174 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 981539004175 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 981539004176 dimerization interface [polypeptide binding]; other site 981539004177 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 981539004178 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 981539004179 active site 981539004180 catalytic tetrad [active] 981539004181 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 981539004182 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 981539004183 dimer interface [polypeptide binding]; other site 981539004184 phosphorylation site [posttranslational modification] 981539004185 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 981539004186 ATP binding site [chemical binding]; other site 981539004187 Mg2+ binding site [ion binding]; other site 981539004188 G-X-G motif; other site 981539004189 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 981539004190 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 981539004191 active site 981539004192 phosphorylation site [posttranslational modification] 981539004193 intermolecular recognition site; other site 981539004194 dimerization interface [polypeptide binding]; other site 981539004195 Transcriptional regulatory protein, C terminal; Region: Trans_reg_C; smart00862 981539004196 DNA binding site [nucleotide binding] 981539004197 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 981539004198 synthetase active site [active] 981539004199 NTP binding site [chemical binding]; other site 981539004200 metal binding site [ion binding]; metal-binding site 981539004201 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 981539004202 dimer interface [polypeptide binding]; other site 981539004203 conserved gate region; other site 981539004204 ABC-ATPase subunit interface; other site 981539004205 sulfate ABC transporter, ATP-binding protein; Region: 3a0106s01; TIGR00968 981539004206 ATP-binding cassette domain of the osmoprotectant transporter; Region: ABC_OpuCA_Osmoprotection; cd03295 981539004207 Walker A/P-loop; other site 981539004208 ATP binding site [chemical binding]; other site 981539004209 Q-loop/lid; other site 981539004210 ABC transporter signature motif; other site 981539004211 Walker B; other site 981539004212 D-loop; other site 981539004213 H-loop/switch region; other site 981539004214 Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069 981539004215 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 981539004216 ABC-ATPase subunit interface; other site 981539004217 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 981539004218 MarR family; Region: MarR_2; pfam12802 981539004219 MarR family; Region: MarR_2; cl17246 981539004220 Quinone oxidoreductase (QOR); Region: quinone_oxidoreductase_like_1; cd08243 981539004221 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 981539004222 putative NAD(P) binding site [chemical binding]; other site 981539004223 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 981539004224 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 981539004225 ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254 981539004226 Walker A/P-loop; other site 981539004227 ATP binding site [chemical binding]; other site 981539004228 Q-loop/lid; other site 981539004229 ABC transporter signature motif; other site 981539004230 Walker B; other site 981539004231 D-loop; other site 981539004232 H-loop/switch region; other site 981539004233 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 981539004234 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 981539004235 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 981539004236 Walker A/P-loop; other site 981539004237 ATP binding site [chemical binding]; other site 981539004238 Q-loop/lid; other site 981539004239 ABC transporter signature motif; other site 981539004240 Walker B; other site 981539004241 D-loop; other site 981539004242 H-loop/switch region; other site 981539004243 Transcriptional regulators [Transcription]; Region: MarR; COG1846 981539004244 MarR family; Region: MarR_2; pfam12802 981539004245 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 981539004246 active site 981539004247 catalytic residues [active] 981539004248 metal binding site [ion binding]; metal-binding site 981539004249 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 981539004250 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 981539004251 Coenzyme A binding pocket [chemical binding]; other site 981539004252 glutamate dehydrogenase; Provisional; Region: PRK09414 981539004253 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 981539004254 NAD(P) binding domain of glutamate dehydrogenase, subgroup 2; Region: NAD_bind_2_Glu_DH; cd05313 981539004255 NAD(P) binding site [chemical binding]; other site 981539004256 Enzyme related to GTP cyclohydrolase I [General function prediction only]; Region: COG0780 981539004257 7-cyano-7-deazaguanosine (preQ0) biosynthesis protein QueE; Region: Bsubt_queE; TIGR03365 981539004258 putative 7-cyano-7-deazaguanosine (preQ0) biosynthesis protein QueE; Region: rSAM_QueE_Ecoli; TIGR04322 981539004259 6-pyruvoyl tetrahydropterin synthase; Region: PTPS; pfam01242 981539004260 active site 981539004261 ExsB is a transcription regulator related protein. It is a subfamily of a Adenosine nucleotide binding superfamily of proteins. This protein family is represented by a single member in nearly every completed large (> 1000 genes) prokaryotic genome. In...; Region: ExsB; cd01995 981539004262 Ligand Binding Site [chemical binding]; other site 981539004263 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 981539004264 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 981539004265 ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254 981539004266 Walker A/P-loop; other site 981539004267 ATP binding site [chemical binding]; other site 981539004268 Q-loop/lid; other site 981539004269 ABC transporter signature motif; other site 981539004270 Walker B; other site 981539004271 D-loop; other site 981539004272 H-loop/switch region; other site 981539004273 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 981539004274 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 981539004275 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 981539004276 Walker A/P-loop; other site 981539004277 ATP binding site [chemical binding]; other site 981539004278 Q-loop/lid; other site 981539004279 ABC transporter signature motif; other site 981539004280 Walker B; other site 981539004281 D-loop; other site 981539004282 H-loop/switch region; other site 981539004283 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 981539004284 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 981539004285 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 981539004286 ABC transporter; Region: ABC_tran_2; pfam12848 981539004287 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 981539004288 tRNA CCA-pyrophosphorylase; Provisional; Region: PRK13299 981539004289 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 981539004290 active site 981539004291 NTP binding site [chemical binding]; other site 981539004292 metal binding triad [ion binding]; metal-binding site 981539004293 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 981539004294 tRNA nucleotidyltransferase domain 2 putative; Region: tRNA_NucTran2_2; pfam13735 981539004295 dihydrodipicolinate reductase; Provisional; Region: PRK00048 981539004296 Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113 981539004297 Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173 981539004298 EDD domain protein, DegV family; Region: DegV; TIGR00762 981539004299 Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645 981539004300 Protein of unknown function (DUF1149); Region: DUF1149; pfam06619 981539004301 Protein of unknown function (DUF1211); Region: DUF1211; cl01421 981539004302 Muramidase (flagellum-specific) [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FlgJ; COG1705 981539004303 1-deoxy-D-xylulose-5-phosphate synthase; Provisional; Region: PRK12315 981539004304 Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007 981539004305 TPP-binding site; other site 981539004306 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 981539004307 PYR/PP interface [polypeptide binding]; other site 981539004308 dimer interface [polypeptide binding]; other site 981539004309 TPP binding site [chemical binding]; other site 981539004310 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 981539004311 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 981539004312 atypical (a) SDRs, subgroup 5; Region: SDR_a5; cd05243 981539004313 NADH(P)-binding; Region: NAD_binding_10; pfam13460 981539004314 NAD(P) binding site [chemical binding]; other site 981539004315 putative active site [active] 981539004316 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 981539004317 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 981539004318 active site 981539004319 catalytic tetrad [active] 981539004320 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 981539004321 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 981539004322 active site 981539004323 catalytic tetrad [active] 981539004324 truncated bacterial low temperature requirement A protein 981539004325 truncated bacterial low temperature requirement A protein 981539004326 bifunctional homocysteine S-methyltransferase/5,10-methylenetetrahydrofolate reductase protein; Reviewed; Region: PRK08645 981539004327 Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; cl14105 981539004328 Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cd00537 981539004329 FAD binding site [chemical binding]; other site 981539004330 5-methyltetrahydropteroyltriglutamate--homocysteine S-methyltransferase; Provisional; Region: PRK05222 981539004331 CIMS - Cobalamine-independent methonine synthase, or MetE, N-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_N_terminal_like; cd03312 981539004332 THF binding site; other site 981539004333 CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311 981539004334 substrate binding site [chemical binding]; other site 981539004335 THF binding site; other site 981539004336 zinc-binding site [ion binding]; other site 981539004337 PTS system 2-O-a-mannosyl-D-glycerate specific transporter subunit IIABC; Provisional; Region: PRK09765 981539004338 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 981539004339 active site 981539004340 phosphorylation site [posttranslational modification] 981539004341 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569 981539004342 active site 981539004343 P-loop; other site 981539004344 phosphorylation site [posttranslational modification] 981539004345 Phosphotransferase system, fructose-specific IIC component [Carbohydrate transport and metabolism]; Region: FruA; COG1299 981539004346 Fructose-1-phosphate kinase and related fructose-6-phosphate kinase (PfkB) [Carbohydrate transport and metabolism]; Region: FruK; COG1105 981539004347 1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164 981539004348 putative substrate binding site [chemical binding]; other site 981539004349 putative ATP binding site [chemical binding]; other site 981539004350 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 981539004351 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 981539004352 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 981539004353 Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492 981539004354 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 981539004355 Uncharacterized protein family (UPF0157); Region: UPF0157; pfam04229 981539004356 tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026 981539004357 16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK00122 981539004358 RimM N-terminal domain; Region: RimM; pfam01782 981539004359 PRC-barrel domain; Region: PRC; pfam05239 981539004360 Predicted RNA-binding protein (contains KH domain) [General function prediction only]; Region: COG1837 981539004361 KH domain; Region: KH_4; pfam13083 981539004362 G-X-X-G motif; other site 981539004363 Ribosomal protein S16 [Translation, ribosomal structure and biogenesis]; Region: RpsP; COG0228 981539004364 Putative SAM-dependent methyltransferase; Region: SAM_MT; cl17517 981539004365 Uncharacterized conserved protein [Function unknown]; Region: COG0398 981539004366 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 981539004367 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 981539004368 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 981539004369 FtsX-like permease family; Region: FtsX; pfam02687 981539004370 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 981539004371 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 981539004372 Walker A/P-loop; other site 981539004373 ATP binding site [chemical binding]; other site 981539004374 Q-loop/lid; other site 981539004375 ABC transporter signature motif; other site 981539004376 Walker B; other site 981539004377 D-loop; other site 981539004378 H-loop/switch region; other site 981539004379 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 981539004380 HlyD family secretion protein; Region: HlyD_3; pfam13437 981539004381 carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294 981539004382 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 981539004383 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 981539004384 Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787 981539004385 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 981539004386 ATP-grasp domain; Region: ATP-grasp_4; cl17255 981539004387 Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424 981539004388 IMP binding site; other site 981539004389 dimer interface [polypeptide binding]; other site 981539004390 interdomain contacts; other site 981539004391 partial ornithine binding site; other site 981539004392 carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564 981539004393 Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; smart01097 981539004394 Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744 981539004395 catalytic site [active] 981539004396 subunit interface [polypeptide binding]; other site 981539004397 aspartate carbamoyltransferase catalytic subunit; Provisional; Region: pyrB; PRK00856 981539004398 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 981539004399 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 981539004400 uracil transporter; Provisional; Region: PRK10720 981539004401 Pyrimidine operon attenuation protein/uracil phosphoribosyltransferase [Nucleotide transport and metabolism]; Region: PyrR; COG2065 981539004402 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 981539004403 active site 981539004404 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 981539004405 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 981539004406 RNA binding surface [nucleotide binding]; other site 981539004407 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 981539004408 active site 981539004409 lipoprotein signal peptidase; Provisional; Region: PRK14797 981539004410 lipoprotein signal peptidase; Provisional; Region: PRK14787 981539004411 Transcriptional regulator [Transcription]; Region: LysR; COG0583 981539004412 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 981539004413 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 981539004414 dimerization interface [polypeptide binding]; other site 981539004415 50S ribosomal protein L27; Validated; Region: rpmA; PRK05435 981539004416 Protein of unknown function (DUF464); Region: DUF464; pfam04327 981539004417 50S ribosomal protein L21; Validated; Region: rplU; PRK05573 981539004418 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 981539004419 Coenzyme A binding pocket [chemical binding]; other site 981539004420 Putative enzyme of poly-gamma-glutamate biosynthesis (capsule formation) [Cell envelope biogenesis, outer membrane]; Region: PgsA; COG2843 981539004421 CapA and related proteins, metallophosphatase domain; Region: MPP_CapA; cd07381 981539004422 putative active site [active] 981539004423 putative metal binding site [ion binding]; other site 981539004424 thiamine biosynthesis protein ThiI; Provisional; Region: PRK01565 981539004425 THUMP domain of thiamine biosynthesis protein ThiI; Region: THUMP_ThiI; cd11716 981539004426 ThiI is required for thiazole synthesis in the thiamine biosynthesis pathway. It belongs to the Adenosine Nucleotide Hydrolysis suoerfamily and predicted to bind to Adenosine nucleotide; Region: ThiI; cd01712 981539004427 Ligand Binding Site [chemical binding]; other site 981539004428 Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104 981539004429 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 981539004430 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 981539004431 catalytic residue [active] 981539004432 folylpolyglutamate synthase/dihydrofolate synthase; Region: folC; TIGR01499 981539004433 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 981539004434 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 981539004435 L-2-hydroxyisocapronate dehydrogenases and some bacterial L-lactate dehydrogenases; Region: HicDH_like; cd05291 981539004436 tetramer (dimer of dimers) interface [polypeptide binding]; other site 981539004437 L-lactate dehydrogenase; Region: L-LDH-NAD; TIGR01771 981539004438 NAD binding site [chemical binding]; other site 981539004439 dimer interface [polypeptide binding]; other site 981539004440 substrate binding site [chemical binding]; other site 981539004441 hypothetical protein; Provisional; Region: PRK13676 981539004442 prephenate dehydrogenase; Validated; Region: PRK06545 981539004443 prephenate dehydrogenase; Validated; Region: PRK08507 981539004444 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 981539004445 Chorismate synthase [Amino acid transport and metabolism]; Region: AroC; COG0082 981539004446 Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304 981539004447 Tetramer interface [polypeptide binding]; other site 981539004448 active site 981539004449 FMN-binding site [chemical binding]; other site 981539004450 Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195 981539004451 Iron-containing alcohol dehydrogenase; Region: Fe-ADH; pfam00465 981539004452 active site 981539004453 dimer interface [polypeptide binding]; other site 981539004454 metal binding site [ion binding]; metal-binding site 981539004455 shikimate 5-dehydrogenase; Reviewed; Region: aroE; PRK00258 981539004456 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 981539004457 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 981539004458 shikimate binding site; other site 981539004459 NAD(P) binding site [chemical binding]; other site 981539004460 3-dehydroquinate dehydratase [Amino acid transport and metabolism]; Region: AroD; COG0710 981539004461 Type I 3-dehydroquinase, (3-dehydroquinate dehydratase or DHQase); Region: DHQase_I; cd00502 981539004462 active site 981539004463 catalytic residue [active] 981539004464 dimer interface [polypeptide binding]; other site 981539004465 Predicted SAM-dependent methyltransferases [General function prediction only]; Region: COG1092 981539004466 Middle domain of the SAM-dependent methyltransferase RlmI and related proteins; Region: RlmI_M_like; cd11572 981539004467 putative RNA binding site [nucleotide binding]; other site 981539004468 Methyltransferase domain; Region: Methyltransf_26; pfam13659 981539004469 Phosphoglycerol transferase and related proteins, alkaline phosphatase superfamily [Cell envelope biogenesis, outer membrane]; Region: MdoB; COG1368 981539004470 Sulfatase; Region: Sulfatase; pfam00884 981539004471 Ribosomal protein L20; Region: Ribosomal_L20; cd07026 981539004472 23S rRNA binding site [nucleotide binding]; other site 981539004473 L21 binding site [polypeptide binding]; other site 981539004474 L13 binding site [polypeptide binding]; other site 981539004475 50S ribosomal protein L35; Reviewed; Region: rpmI; PRK00172 981539004476 translation initiation factor IF-3; Reviewed; Region: infC; PRK00028 981539004477 Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198 981539004478 Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707 981539004479 cytidylate kinase; Provisional; Region: cmk; PRK00023 981539004480 Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020 981539004481 CMP-binding site; other site 981539004482 The sites determining sugar specificity; other site 981539004483 peptidase T; Region: peptidase-T; TIGR01882 981539004484 M20 Peptidase T specifically cleaves tripeptides; Region: M20_peptT; cd03892 981539004485 metal binding site [ion binding]; metal-binding site 981539004486 dimer interface [polypeptide binding]; other site 981539004487 GBS Bsp-like repeat; Region: GBS_Bsp-like; pfam08481 981539004488 GBS Bsp-like repeat; Region: GBS_Bsp-like; pfam08481 981539004489 GBS Bsp-like repeat; Region: GBS_Bsp-like; pfam08481 981539004490 GBS Bsp-like repeat; Region: GBS_Bsp-like; pfam08481 981539004491 GBS Bsp-like repeat; Region: GBS_Bsp-like; pfam08481 981539004492 GBS Bsp-like repeat; Region: GBS_Bsp-like; pfam08481 981539004493 Endo-N-acetylmuramidases (muramidases) are lysozymes (also referred to as peptidoglycan hydrolases) that degrade bacterial cell walls by catalyzing the hydrolysis of 1,4-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues; Region: GH25_muramidase; cl10448 981539004494 Glycosyl hydrolases family 25; Region: Glyco_hydro_25; pfam01183 981539004495 active site 981539004496 GBS Bsp-like repeat; Region: GBS_Bsp-like; pfam08481 981539004497 GBS Bsp-like repeat; Region: GBS_Bsp-like; pfam08481 981539004498 GBS Bsp-like repeat; Region: GBS_Bsp-like; pfam08481 981539004499 Surface antigen [General function prediction only]; Region: COG3942 981539004500 CHAP domain; Region: CHAP; pfam05257 981539004501 GBS Bsp-like repeat; Region: GBS_Bsp-like; pfam08481 981539004502 undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714 981539004503 Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187 981539004504 Ligand binding site; other site 981539004505 Putative Catalytic site; other site 981539004506 DXD motif; other site 981539004507 Glucosyl transferase GtrII; Region: Glucos_trans_II; pfam14264 981539004508 Phosphoglycerol transferase and related proteins, alkaline phosphatase superfamily [Cell envelope biogenesis, outer membrane]; Region: MdoB; COG1368 981539004509 Sulfatase; Region: Sulfatase; pfam00884 981539004510 Rhamnan synthesis protein F; Region: RgpF; pfam05045 981539004511 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 981539004512 active site 981539004513 ABC-type polysaccharide/polyol phosphate transport system, ATPase component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagH; COG1134 981539004514 ATP-binding cassette component of polysaccharide transport system; Region: ABC_KpsT_Wzt; cd03220 981539004515 Walker A/P-loop; other site 981539004516 ATP binding site [chemical binding]; other site 981539004517 Q-loop/lid; other site 981539004518 ABC transporter signature motif; other site 981539004519 Walker B; other site 981539004520 D-loop; other site 981539004521 H-loop/switch region; other site 981539004522 ABC-type polysaccharide/polyol phosphate export systems, permease component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagG; COG1682 981539004523 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 981539004524 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 981539004525 Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_d; cd04196 981539004526 Probable Catalytic site; other site 981539004527 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 981539004528 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 981539004529 dTDP-6-deoxy-L-lyxo-4-hexulose reductase and related proteins, extended (e) SDRs; Region: dTDP_HR_like_SDR_e; cd05254 981539004530 RmlD substrate binding domain; Region: RmlD_sub_bind; pfam04321 981539004531 NADP binding site [chemical binding]; other site 981539004532 active site 981539004533 putative substrate binding site [chemical binding]; other site 981539004534 Predicted metal-sulfur cluster biosynthetic enzyme [General function prediction only]; Region: PaaD; COG2151 981539004535 RNA polymerase sigma factor RpoD; Validated; Region: PRK09210 981539004536 Sigma-70 factor, region 1.1; Region: Sigma70_r1_1; pfam03979 981539004537 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 981539004538 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 981539004539 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 981539004540 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 981539004541 DNA binding residues [nucleotide binding] 981539004542 DNA primase; Validated; Region: dnaG; PRK05667 981539004543 CHC2 zinc finger; Region: zf-CHC2; pfam01807 981539004544 DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275 981539004545 TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364 981539004546 active site 981539004547 metal binding site [ion binding]; metal-binding site 981539004548 interdomain interaction site; other site 981539004549 Large-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscL; COG1970 981539004550 large-conductance mechanosensitive channel; Reviewed; Region: mscL; PRK00567 981539004551 30S ribosomal protein S21; Reviewed; Region: rpsU; PRK00270 981539004552 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 981539004553 PGAP1-like protein; Region: PGAP1; pfam07819 981539004554 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243 981539004555 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 981539004556 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_16; cd07263 981539004557 Esterase/lipase [Lipid metabolism]; Region: Aes; COG0657 981539004558 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 981539004559 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 981539004560 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 981539004561 substrate binding pocket [chemical binding]; other site 981539004562 membrane-bound complex binding site; other site 981539004563 hinge residues; other site 981539004564 transaminase; Validated; Region: PRK07324 981539004565 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 981539004566 pyridoxal 5'-phosphate binding site [chemical binding]; other site 981539004567 homodimer interface [polypeptide binding]; other site 981539004568 catalytic residue [active] 981539004569 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 981539004570 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 981539004571 substrate binding pocket [chemical binding]; other site 981539004572 membrane-bound complex binding site; other site 981539004573 hinge residues; other site 981539004574 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 981539004575 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 981539004576 substrate binding pocket [chemical binding]; other site 981539004577 membrane-bound complex binding site; other site 981539004578 hinge residues; other site 981539004579 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 981539004580 glycogen/starch/alpha-glucan phosphorylases; Region: P_ylase; TIGR02093 981539004581 4-alpha-glucanotransferase; Provisional; Region: PRK14508 981539004582 Transcriptional regulators [Transcription]; Region: PurR; COG1609 981539004583 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 981539004584 DNA binding site [nucleotide binding] 981539004585 domain linker motif; other site 981539004586 Ligand-binding domain of uncharacterized transcription regulator ycjW which is a member of the LacI-GalR family repressors; Region: PBP1_ycjW_transcription_regulator_like; cd06294 981539004587 putative dimerization interface [polypeptide binding]; other site 981539004588 putative ligand binding site [chemical binding]; other site 981539004589 Maltose-binding periplasmic proteins/domains [Carbohydrate transport and metabolism]; Region: MalE; COG2182 981539004590 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 981539004591 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 981539004592 dimer interface [polypeptide binding]; other site 981539004593 conserved gate region; other site 981539004594 putative PBP binding loops; other site 981539004595 ABC-ATPase subunit interface; other site 981539004596 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 981539004597 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 981539004598 dimer interface [polypeptide binding]; other site 981539004599 conserved gate region; other site 981539004600 putative PBP binding loops; other site 981539004601 ABC-ATPase subunit interface; other site 981539004602 MutT homolog-1 (MTH1) is a member of the Nudix hydrolase superfamily. MTH1, the mammalian counterpart of MutT, hydrolyzes oxidized purine nucleoside triphosphates, such as 8-oxo-dGTP and 2-hydroxy-ATP, to monophosphates, thereby preventing the...; Region: MTH1; cd03427 981539004603 putative active site [active] 981539004604 nucleotide binding site [chemical binding]; other site 981539004605 nudix motif; other site 981539004606 putative metal binding site [ion binding]; other site 981539004607 excinuclease ABC subunit B; Provisional; Region: PRK05298 981539004608 Myosin and Kinesin motor domain. These ATPases belong to the P-loop NTPase family and provide the driving force in myosin and kinesin mediated processes; Region: Motor_domain; cl00286 981539004609 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 981539004610 ATP-binding site [chemical binding]; other site 981539004611 ATP binding site [chemical binding]; other site 981539004612 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 981539004613 nucleotide binding region [chemical binding]; other site 981539004614 ATP-binding site [chemical binding]; other site 981539004615 Ultra-violet resistance protein B; Region: UvrB; pfam12344 981539004616 UvrB/uvrC motif; Region: UVR; pfam02151 981539004617 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 981539004618 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 981539004619 substrate binding pocket [chemical binding]; other site 981539004620 membrane-bound complex binding site; other site 981539004621 hinge residues; other site 981539004622 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 981539004623 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 981539004624 substrate binding pocket [chemical binding]; other site 981539004625 membrane-bound complex binding site; other site 981539004626 hinge residues; other site 981539004627 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 981539004628 dimer interface [polypeptide binding]; other site 981539004629 conserved gate region; other site 981539004630 putative PBP binding loops; other site 981539004631 ABC-ATPase subunit interface; other site 981539004632 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 981539004633 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 981539004634 Walker A/P-loop; other site 981539004635 ATP binding site [chemical binding]; other site 981539004636 Q-loop/lid; other site 981539004637 ABC transporter signature motif; other site 981539004638 Walker B; other site 981539004639 D-loop; other site 981539004640 H-loop/switch region; other site 981539004641 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 981539004642 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 981539004643 Walker A/P-loop; other site 981539004644 ATP binding site [chemical binding]; other site 981539004645 Q-loop/lid; other site 981539004646 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 981539004647 H-loop/switch region; other site 981539004648 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 981539004649 GTPase CgtA; Reviewed; Region: obgE; PRK12297 981539004650 GTP1/OBG; Region: GTP1_OBG; pfam01018 981539004651 Obg GTPase; Region: Obg; cd01898 981539004652 G1 box; other site 981539004653 GTP/Mg2+ binding site [chemical binding]; other site 981539004654 Switch I region; other site 981539004655 G2 box; other site 981539004656 G3 box; other site 981539004657 Switch II region; other site 981539004658 G4 box; other site 981539004659 G5 box; other site 981539004660 Domain of unknown function (DUF1967); Region: DUF1967; pfam09269 981539004661 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 981539004662 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 981539004663 RNA binding surface [nucleotide binding]; other site 981539004664 Pseudouridine synthase, Escherichia coli RsuA like; Region: PseudoU_synth_RsuA; cd02553 981539004665 active site 981539004666 uracil binding [chemical binding]; other site 981539004667 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 981539004668 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 981539004669 peptide binding site [polypeptide binding]; other site 981539004670 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 981539004671 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 981539004672 peptide binding site [polypeptide binding]; other site 981539004673 MarR family; Region: MarR_2; cl17246 981539004674 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 981539004675 Predicted membrane protein [Function unknown]; Region: COG2364 981539004676 Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792 981539004677 putative transporter; Provisional; Region: PRK11660 981539004678 Sulfate transporter family; Region: Sulfate_transp; pfam00916 981539004679 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 981539004680 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 981539004681 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 981539004682 non-specific DNA binding site [nucleotide binding]; other site 981539004683 salt bridge; other site 981539004684 sequence-specific DNA binding site [nucleotide binding]; other site 981539004685 Putative zinc ribbon domain; Region: Zn_ribbon_2; pfam12674 981539004686 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 981539004687 nucleoside/Zn binding site; other site 981539004688 dimer interface [polypeptide binding]; other site 981539004689 catalytic motif [active] 981539004690 multidrug efflux pump VmrA; Reviewed; Region: vmrA; PRK09575 981539004691 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Streptococcus aureus MepA; Region: MATE_MepA_like; cd13143 981539004692 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 981539004693 MarR family; Region: MarR_2; pfam12802 981539004694 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 981539004695 Coenzyme A binding pocket [chemical binding]; other site 981539004696 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 981539004697 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 981539004698 potential frameshift: common BLAST hit: gi|325978649|ref|YP_004288365.1| putative auxin efflux carrier component 8 981539004699 Membrane transport protein; Region: Mem_trans; cl09117 981539004700 CAAX protease self-immunity; Region: Abi; cl00558 981539004701 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 981539004702 Coenzyme A binding pocket [chemical binding]; other site 981539004703 SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase [Translation, ribosomal structure and biogenesis]; Region: TrmA; COG2265 981539004704 Predicted RNA-binding protein, contains TRAM domain [General function prediction only]; Region: COG3269 981539004705 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 981539004706 S-adenosylmethionine binding site [chemical binding]; other site 981539004707 Transcriptional regulator [Transcription]; Region: LytR; COG1316 981539004708 prephenate dehydratase; Provisional; Region: PRK11898 981539004709 Prephenate dehydratase; Region: PDT; pfam00800 981539004710 C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905 981539004711 putative L-Phe binding site [chemical binding]; other site 981539004712 Shikimate kinase [Amino acid transport and metabolism]; Region: AroK; COG0703 981539004713 Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464 981539004714 ADP binding site [chemical binding]; other site 981539004715 magnesium binding site [ion binding]; other site 981539004716 putative shikimate binding site; other site 981539004717 3-phosphoshikimate 1-carboxyvinyltransferase; Provisional; Region: PRK02427 981539004718 EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556 981539004719 hinge; other site 981539004720 active site 981539004721 GTP-binding protein LepA; Provisional; Region: PRK05433 981539004722 LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890 981539004723 G1 box; other site 981539004724 putative GEF interaction site [polypeptide binding]; other site 981539004725 GTP/Mg2+ binding site [chemical binding]; other site 981539004726 Switch I region; other site 981539004727 G2 box; other site 981539004728 G3 box; other site 981539004729 Switch II region; other site 981539004730 G4 box; other site 981539004731 G5 box; other site 981539004732 lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699 981539004733 lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane. LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709 981539004734 GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421 981539004735 Stu0660-like CRISPR/Cas system-associated protein Csn2; Region: Stu0660_Csn2; cd12217 981539004736 tetramer interface [polypeptide binding]; other site 981539004737 putative DNA binding site [nucleotide binding]; other site 981539004738 CRISPR/Cas system-associated protein Cas2; Region: Cas2_I_II_III; cd09638 981539004739 CRISPR/Cas system-associated protein Cas1; Region: Cas1_II; cd09720 981539004740 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cl00083 981539004741 CRISPR-associated protein Cas9/Csn1, subtype II/NMEMI; Region: cas_Csn1; TIGR01865 981539004742 Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413 981539004743 active site 981539004744 multimer interface [polypeptide binding]; other site 981539004745 Uncharacterized protein family (UPF0150); Region: UPF0150; pfam03681 981539004746 YcfA-like protein; Region: YcfA; pfam07927 981539004747 CRISPR/Cas system-associated protein Csn2; Region: Csn2; cd09758 981539004748 CRISPR type II-A/NMEMI-associated protein Csn2; Region: cas_Csn2; TIGR01866 981539004749 tetramer interface [polypeptide binding]; other site 981539004750 putative DNA binding site [nucleotide binding]; other site 981539004751 Ca binding site [ion binding]; other site 981539004752 Ca binding site [ion binding]; other site 981539004753 CRISPR/Cas system-associated protein Cas2; Region: Cas2_I_II_III; cd09638 981539004754 CRISPR/Cas system-associated protein Cas1; Region: Cas1_II; cd09720 981539004755 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cl00083 981539004756 CRISPR/Cas system-associated protein Cas9; Region: Csn1; cd09643 981539004757 Predicted membrane protein [Function unknown]; Region: COG4478 981539004758 HAD-superfamily subfamily IIA hydrolase, TIGR01457; Region: HAD-SF-IIA-hyp2 981539004759 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 981539004760 active site 981539004761 motif I; other site 981539004762 motif II; other site 981539004763 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 981539004764 Hydrolase of X-linked nucleoside diphosphate N terminal; Region: Nudix_N; pfam12535 981539004765 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_14; cd04672 981539004766 nudix motif; other site 981539004767 Acyl-ACP thioesterase; Region: Acyl-ACP_TE; pfam01643 981539004768 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 981539004769 active site 981539004770 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 981539004771 active site 2 [active] 981539004772 active site 1 [active] 981539004773 coproporphyrinogen III oxidase; Provisional; Region: PRK08599 981539004774 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 981539004775 FeS/SAM binding site; other site 981539004776 HemN C-terminal domain; Region: HemN_C; pfam06969 981539004777 phosphoglucosamine mutase; Provisional; Region: glmM; PRK14316 981539004778 GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802 981539004779 active site 981539004780 substrate binding site [chemical binding]; other site 981539004781 metal binding site [ion binding]; metal-binding site 981539004782 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4856 981539004783 YbbR-like protein; Region: YbbR; pfam07949 981539004784 Uncharacterized conserved protein [Function unknown]; Region: COG1624 981539004785 DisA bacterial checkpoint controller nucleotide-binding; Region: DisA_N; pfam02457 981539004786 truncated UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase 981539004787 truncated UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase 981539004788 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyric Acid Synthase (CobQ); Region: GATase1_CobQ; cd01750 981539004789 catalytic triad [active] 981539004790 enolase; Provisional; Region: eno; PRK00077 981539004791 Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313 981539004792 dimer interface [polypeptide binding]; other site 981539004793 metal binding site [ion binding]; metal-binding site 981539004794 substrate binding pocket [chemical binding]; other site 981539004795 Protein of unknown function (DUF1694); Region: DUF1694; pfam07997 981539004796 Glycerate kinase [Carbohydrate transport and metabolism]; Region: COG1929 981539004797 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cd02883 981539004798 nudix motif; other site 981539004799 YSIRK type signal peptide; Region: YSIRK_signal; pfam04650 981539004800 Family 41 Carbohydrate-Binding Module from pullulanase-like enzymes; Region: CBM41_pullulanase; cd10315 981539004801 carbohydrate binding site [chemical binding]; other site 981539004802 Bacterial pullanase-associated domain; Region: PUD; pfam03714 981539004803 carbohydrate binding site [chemical binding]; other site 981539004804 Alpha amylase catalytic domain found in bacterial cyclomaltodextrinases and related proteins; Region: AmyAc_bac_CMD_like_2; cd11339 981539004805 Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366 981539004806 active site 981539004807 catalytic site [active] 981539004808 pullulanase, extracellular, Gram-positive; Region: pullulan_Gpos; TIGR02102 981539004809 Family 41 Carbohydrate-Binding Module from pullulanase-like enzymes; Region: CBM41_pullulanase; cd10315 981539004810 carbohydrate binding site [chemical binding]; other site 981539004811 Family 41 Carbohydrate-Binding Module from pullulanase-like enzymes; Region: CBM41_pullulanase; cd10315 981539004812 carbohydrate binding site [chemical binding]; other site 981539004813 Early set domain associated with the catalytic domain of pullulanase (also called dextrinase and alpha-dextrin endo-1,6-alpha glucosidase); Region: E_set_Pullulanase; cd02860 981539004814 Alpha amylase catalytic domain found in Pullulanase (also called dextrinase; alpha-dextrin endo-1,6-alpha glucosidase), limit dextrinase, and related proteins; Region: AmyAc_Pullulanase_LD-like; cd11341 981539004815 Ca binding site [ion binding]; other site 981539004816 active site 981539004817 catalytic site [active] 981539004818 LPXTG-motif cell wall anchor domain; Region: LPXTG_anchor; TIGR01167 981539004819 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in Escherichia coli phosphoribosyl-ATP pyrophosphohydrolase (HisIE or PRATP-PH) and its homologs; Region: NTP-PPase_HisIE_like; cd11534 981539004820 metal binding site [ion binding]; metal-binding site 981539004821 phosphoribosyl-AMP cyclohydrolase; Reviewed; Region: hisI; PRK00051 981539004822 The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731 981539004823 Histidine biosynthesis protein; Region: His_biosynth; pfam00977 981539004824 substrate binding site [chemical binding]; other site 981539004825 glutamase interaction surface [polypeptide binding]; other site 981539004826 HisA. Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1...; Region: HisA; cd04732 981539004827 phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; Region: TIGR00007 981539004828 catalytic residues [active] 981539004829 imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13141 981539004830 Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748 981539004831 putative active site [active] 981539004832 oxyanion strand; other site 981539004833 catalytic triad [active] 981539004834 Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cd07914 981539004835 putative active site pocket [active] 981539004836 4-fold oligomerization interface [polypeptide binding]; other site 981539004837 metal binding residues [ion binding]; metal-binding site 981539004838 3-fold/trimer interface [polypeptide binding]; other site 981539004839 phosphoserine phosphatase SerB; Region: serB; TIGR00338 981539004840 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 981539004841 motif II; other site 981539004842 Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572 981539004843 histidinol dehydrogenase; Region: hisD; TIGR00069 981539004844 NAD binding site [chemical binding]; other site 981539004845 dimerization interface [polypeptide binding]; other site 981539004846 product binding site; other site 981539004847 substrate binding site [chemical binding]; other site 981539004848 zinc binding site [ion binding]; other site 981539004849 catalytic residues [active] 981539004850 ATP phosphoribosyltransferase catalytic subunit; Reviewed; Region: hisG; PRK01686 981539004851 ATP phosphoribosyltransferase [Amino acid transport and metabolism]; Region: HisG; COG0040 981539004852 ATP phosphoribosyltransferase, regulatory subunit; Region: hisZ_biosyn_reg; TIGR00443 981539004853 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 981539004854 dimer interface [polypeptide binding]; other site 981539004855 motif 1; other site 981539004856 active site 981539004857 motif 2; other site 981539004858 motif 3; other site 981539004859 Histidinol-phosphate/aromatic aminotransferase and cobyric acid decarboxylase [Amino acid transport and metabolism]; Region: HisC; COG0079 981539004860 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 981539004861 pyridoxal 5'-phosphate binding site [chemical binding]; other site 981539004862 homodimer interface [polypeptide binding]; other site 981539004863 catalytic residue [active] 981539004864 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Provisional; Region: PRK07164 981539004865 Phosphorylase superfamily; Region: PNP_UDP_1; cl00303 981539004866 septation ring formation regulator EzrA; Provisional; Region: PRK04778 981539004867 DNA gyrase subunit B; Validated; Region: gyrB; PRK05644 981539004868 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 981539004869 Mg2+ binding site [ion binding]; other site 981539004870 G-X-G motif; other site 981539004871 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 981539004872 anchoring element; other site 981539004873 dimer interface [polypeptide binding]; other site 981539004874 ATP binding site [chemical binding]; other site 981539004875 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 981539004876 active site 981539004877 putative metal-binding site [ion binding]; other site 981539004878 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 981539004879 haloacid dehalogenase superfamily, subfamily IA, variant 1 with third motif having Dx(3-4)D or Dx(3-4)E; Region: HAD-SF-IA-v1; TIGR01549 981539004880 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 981539004881 motif II; other site 981539004882 Bacterial cell division membrane protein [Cell division and chromosome partitioning]; Region: FtsW; COG0772 981539004883 50S ribosomal protein L19; Provisional; Region: rplS; PRK05338 981539004884 CLC voltage-gated chloride channel. The ClC chloride channels catalyse the selective flow of Cl- ions across cell membranes, thereby regulating electrical excitation in skeletal muscle and the flow of salt and water across epithelial barriers. This...; Region: Voltage_gated_ClC; cl02915 981539004885 Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038 981539004886 Cl- selectivity filter; other site 981539004887 Cl- binding residues [ion binding]; other site 981539004888 pore gating glutamate residue; other site 981539004889 dimer interface [polypeptide binding]; other site 981539004890 hypothetical protein; Provisional; Region: PRK07248 981539004891 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 981539004892 cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814; cl03223 981539004893 FeS assembly protein SufB; Region: sufB; TIGR01980 981539004894 flavodoxin; Validated; Region: PRK07308 981539004895 Adenosine deaminase [Nucleotide transport and metabolism]; Region: Add; COG1816 981539004896 Adenosine deaminase (ADA) is a monomeric zinc dependent enzyme which catalyzes the irreversible hydrolytic deamination of both adenosine, as well as desoxyadenosine, to ammonia and inosine or desoxyinosine, respectively. ADA plays an important role in...; Region: ADA; cd01320 981539004897 active site 981539004898 purine riboside binding site [chemical binding]; other site 981539004899 asparaginyl-tRNA synthetase; Validated; Region: asnC; PRK03932 981539004900 AsnRS_cyto_like_N: N-terminal, anticodon recognition domain of the type found in human and Saccharomyces cerevisiae cytoplasmic asparaginyl-tRNA synthetase (AsnRS), in Brugia malayai AsnRs and, in various putative bacterial AsnRSs. This domain is a...; Region: AsnRS_cyto_like_N; cd04323 981539004901 putative dimer interface [polypeptide binding]; other site 981539004902 putative anticodon binding site; other site 981539004903 Asx tRNA synthetase (AspRS/AsnRS) class II core domain. Assignment to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs in the core domain. This family includes AsnRS as well as...; Region: AsxRS_core; cd00776 981539004904 homodimer interface [polypeptide binding]; other site 981539004905 motif 1; other site 981539004906 motif 2; other site 981539004907 active site 981539004908 motif 3; other site 981539004909 Chagasin family peptidase inhibitor I42; Region: Inhibitor_I42; pfam09394 981539004910 aspartate aminotransferase; Provisional; Region: PRK05764 981539004911 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 981539004912 pyridoxal 5'-phosphate binding site [chemical binding]; other site 981539004913 homodimer interface [polypeptide binding]; other site 981539004914 catalytic residue [active] 981539004915 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5353 981539004916 bifunctional ATP-dependent DNA helicase/DNA polymerase III subunit epsilon; Validated; Region: PRK07246 981539004917 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 981539004918 active site 981539004919 catalytic site [active] 981539004920 substrate binding site [chemical binding]; other site 981539004921 CRISPR/Cas system-associated DinG family helicase Csf4; Region: Csf4_U; cl17460 981539004922 Helicase C-terminal domain; Region: Helicase_C_2; pfam13307 981539004923 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819 981539004924 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4947 981539004925 Putative esterase; Region: Esterase; pfam00756 981539004926 ATP-grasp domain; Region: ATP-grasp_4; pfam13535 981539004927 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 981539004928 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 981539004929 Cell division protein [Cell division and chromosome partitioning]; Region: FtsX; COG2177 981539004930 cell division ABC transporter subunit FtsX; Provisional; Region: ftsX; PRK11026 981539004931 Predicted ATPase involved in cell division [Cell division and chromosome partitioning]; Region: FtsE; COG2884 981539004932 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 981539004933 Walker A/P-loop; other site 981539004934 ATP binding site [chemical binding]; other site 981539004935 Q-loop/lid; other site 981539004936 ABC transporter signature motif; other site 981539004937 Walker B; other site 981539004938 D-loop; other site 981539004939 H-loop/switch region; other site 981539004940 peptide chain release factor 2; Validated; Region: prfB; PRK00578 981539004941 PCRF domain; Region: PCRF; pfam03462 981539004942 RF-1 domain; Region: RF-1; pfam00472 981539004943 Predicted phosphatase/phosphohexomutase [General function prediction only]; Region: COG0637 981539004944 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 981539004945 motif II; other site 981539004946 putative phosphoesterase; Region: acc_ester; TIGR03729 981539004947 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 981539004948 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 981539004949 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; pfam00690 981539004950 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 981539004951 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 981539004952 haloacid dehalogenase-like hydrolase; Region: HAD; pfam12710 981539004953 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 981539004954 Domain of unknown function (DUF1934); Region: DUF1934; pfam09148 981539004955 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 981539004956 HD superfamily phosphohydrolases [General function prediction only]; Region: COG1078 981539004957 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 981539004958 Zn2+ binding site [ion binding]; other site 981539004959 Mg2+ binding site [ion binding]; other site 981539004960 sugar phosphate phosphatase; Provisional; Region: PRK10513 981539004961 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 981539004962 active site 981539004963 motif I; other site 981539004964 motif II; other site 981539004965 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 981539004966 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 981539004967 FemAB family; Region: FemAB; pfam02388 981539004968 FemAB family; Region: FemAB; pfam02388 981539004969 U3 small nucleolar ribonucleoprotein component [Translation, ribosomal structure and biogenesis]; Region: Mpp10; COG5384 981539004970 Acetyltransferase (GNAT) domain; Region: Acetyltransf_6; pfam13480 981539004971 triosephosphate isomerase; Provisional; Region: PRK14567 981539004972 Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311 981539004973 substrate binding site [chemical binding]; other site 981539004974 dimer interface [polypeptide binding]; other site 981539004975 catalytic triad [active] 981539004976 elongation factor Tu; Reviewed; Region: PRK00049 981539004977 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 981539004978 G1 box; other site 981539004979 GEF interaction site [polypeptide binding]; other site 981539004980 GTP/Mg2+ binding site [chemical binding]; other site 981539004981 Switch I region; other site 981539004982 G2 box; other site 981539004983 G3 box; other site 981539004984 Switch II region; other site 981539004985 G4 box; other site 981539004986 G5 box; other site 981539004987 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 981539004988 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 981539004989 Antibiotic Binding Site [chemical binding]; other site 981539004990 Sigma factor regulator N-terminal; Region: Sigma_reg_N; pfam13800 981539004991 Sigma factor regulator C-terminal; Region: Sigma_reg_C; pfam13791 981539004992 RNA polymerase sigma factor, SigM family; Region: SigM_subfam; TIGR02950 981539004993 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 981539004994 DNA binding residues [nucleotide binding] 981539004995 Bacterial cell division membrane protein [Cell division and chromosome partitioning]; Region: FtsW; COG0772 981539004996 phosphoenolpyruvate carboxylase; Reviewed; Region: PRK00009 981539004997 Phosphoenolpyruvate carboxylase [Energy production and conversion]; Region: Ppc; COG2352 981539004998 oligoendopeptidase F; Region: pepF; TIGR00181 981539004999 Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins); Region: GluZincin; cl14813 981539005000 Zn binding site [ion binding]; other site 981539005001 Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per...; Region: GSH_Peroxidase; cd00340 981539005002 catalytic residues [active] 981539005003 dimer interface [polypeptide binding]; other site 981539005004 PlyB is a bacteriophage endolysin that displays potent lytic activity toward Bacillus anthracis. PlyB has an N-terminal glycosyl hydrolase family 25 (GH25) catalytic domain and a C-terminal bacterial SH3-like domain, SH3b. Both domains are required for...; Region: GH25_PlyB-like; cd06523 981539005005 Glycosyl hydrolases family 25; Region: Glyco_hydro_25; pfam01183 981539005006 active site 981539005007 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 981539005008 amidase catalytic site [active] 981539005009 Zn binding residues [ion binding]; other site 981539005010 substrate binding site [chemical binding]; other site 981539005011 This CD includes cysteinyl-tRNA(Pro) deacylases from Haemophilus influenzae and Escherichia coli and other related bacterial proteins. These trans-acting, single-domain proteins are homologs of ProX and also the cis-acting prolyl-tRNA synthetase (ProRS)...; Region: YbaK_deacylase; cd00002 981539005012 putative deacylase active site [active] 981539005013 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 981539005014 catalytic core [active] 981539005015 Predicted hydrolase (HAD superfamily) [General function prediction only]; Region: COG1011 981539005016 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 981539005017 motif II; other site 981539005018 lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484 981539005019 LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322 981539005020 dimer interface [polypeptide binding]; other site 981539005021 putative anticodon binding site; other site 981539005022 Lys_tRNA synthetase (LysRS) class II core domain. Class II LysRS is a dimer which attaches a lysine to the 3' OH group of ribose of the appropriate tRNA. Its assignment to class II aaRS is based upon its structure and the presence of three...; Region: LysRS_core; cd00775 981539005023 motif 1; other site 981539005024 active site 981539005025 motif 2; other site 981539005026 motif 3; other site 981539005027 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 981539005028 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 981539005029 Transcriptional regulator C-terminal region; Region: TetR_C_8; pfam14278 981539005030 Predicted hydrolase (HAD superfamily) [General function prediction only]; Region: COG1011 981539005031 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 981539005032 active site 981539005033 motif I; other site 981539005034 motif II; other site 981539005035 BioY family; Region: BioY; pfam02632 981539005036 Uncharacterized protein conserved in bacteria (DUF2128); Region: DUF2128; pfam09901 981539005037 Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826 981539005038 Peptidase family U32; Region: Peptidase_U32; pfam01136 981539005039 Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826 981539005040 Phosphoribosyltransferase (PRTase) type II; This family contains two enzymes that play an important role in NAD production by either allowing quinolinic acid (QA) , quinolinate phosphoribosyl transferase (QAPRTase), or nicotinic acid (NA), nicotinate...; Region: PRTase_typeII; cl17275 981539005041 Peptidase family U32; Region: Peptidase_U32; pfam01136 981539005042 Protein of unknown function (DUF3270); Region: DUF3270; pfam11674 981539005043 Uncharacterized protein containing a divergent version of the methyl-accepting chemotaxis-like domain [General function prediction only]; Region: COG4768 981539005044 Prolipoprotein diacylglyceryl transferase; Region: LGT; pfam01790 981539005045 HPr kinase/phosphorylase; Provisional; Region: PRK05428 981539005046 HPr Serine kinase N terminus; Region: Hpr_kinase_N; pfam02603 981539005047 HprK/P, the bifunctional histidine-containing protein kinase/phosphatase, controls the phosphorylation state of the phosphocarrier protein HPr and regulates the utilization of carbon sources by gram-positive bacteria. It catalyzes both the ATP-dependent...; Region: HprK_C; cd01918 981539005048 Hpr binding site; other site 981539005049 active site 981539005050 homohexamer subunit interaction site [polypeptide binding]; other site 981539005051 PspC domain; Region: PspC; pfam04024 981539005052 hypothetical protein; Provisional; Region: PRK04351 981539005053 Zn-dependent metalloprotease, SprT family [General function prediction only]; Region: SprT; COG3091 981539005054 Transcriptional accessory protein [Transcription]; Region: Tex; COG2183 981539005055 Tex-like protein N-terminal domain; Region: Tex_N; pfam09371 981539005056 Likely ribonuclease with RNase H fold; Region: YqgFc; smart00732 981539005057 S1_Tex: The C-terminal S1 domain of a transcription accessory factor called Tex, which has been characterized in Bordetella pertussis and Pseudomonas aeruginosa. The tex gene is essential in Bortella pertusis and is named for its role in toxin expression; Region: S1_Tex; cd05685 981539005058 RNA binding site [nucleotide binding]; other site 981539005059 Predicted permeases [General function prediction only]; Region: COG0701 981539005060 Predicted membrane protein [Function unknown]; Region: COG3689 981539005061 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 981539005062 Medium chain dehydrogenases/reductase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR2; cd08268 981539005063 putative NAD(P) binding site [chemical binding]; other site 981539005064 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 981539005065 Helix-Turn-Helix DNA binding domain of the MerR-like transcription regulators YyaN and YraB; Region: HTH_YyaN; cd01109 981539005066 DNA binding residues [nucleotide binding] 981539005067 putative dimer interface [polypeptide binding]; other site 981539005068 signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416 981539005069 SRP54-type protein, helical bundle domain; Region: SRP54_N; pfam02881 981539005070 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 981539005071 P loop; other site 981539005072 GTP binding site [chemical binding]; other site 981539005073 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 981539005074 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 981539005075 active site 981539005076 motif I; other site 981539005077 motif II; other site 981539005078 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 981539005079 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cl17915 981539005080 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 981539005081 active site 981539005082 motif I; other site 981539005083 motif II; other site 981539005084 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 981539005085 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 981539005086 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 981539005087 Walker A/P-loop; other site 981539005088 ATP binding site [chemical binding]; other site 981539005089 Q-loop/lid; other site 981539005090 SMC proteins Flexible Hinge Domain; Region: SMC_hinge; smart00968 981539005091 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 981539005092 ABC transporter signature motif; other site 981539005093 Walker B; other site 981539005094 D-loop; other site 981539005095 H-loop/switch region; other site 981539005096 ribonuclease III; Reviewed; Region: rnc; PRK00102 981539005097 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 981539005098 dimerization interface [polypeptide binding]; other site 981539005099 active site 981539005100 metal binding site [ion binding]; metal-binding site 981539005101 Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048 981539005102 dsRNA binding site [nucleotide binding]; other site 981539005103 Metal-dependent hydrolases of the beta-lactamase superfamily I [General function prediction only]; Region: PhnP; COG1235 981539005104 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 981539005105 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: VicK; COG5002 981539005106 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 981539005107 putative active site [active] 981539005108 heme pocket [chemical binding]; other site 981539005109 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 981539005110 dimer interface [polypeptide binding]; other site 981539005111 phosphorylation site [posttranslational modification] 981539005112 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 981539005113 ATP binding site [chemical binding]; other site 981539005114 Mg2+ binding site [ion binding]; other site 981539005115 G-X-G motif; other site 981539005116 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 981539005117 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 981539005118 active site 981539005119 phosphorylation site [posttranslational modification] 981539005120 intermolecular recognition site; other site 981539005121 dimerization interface [polypeptide binding]; other site 981539005122 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 981539005123 DNA binding site [nucleotide binding] 981539005124 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 981539005125 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 981539005126 Walker A/P-loop; other site 981539005127 ATP binding site [chemical binding]; other site 981539005128 Q-loop/lid; other site 981539005129 ABC transporter signature motif; other site 981539005130 Walker B; other site 981539005131 D-loop; other site 981539005132 H-loop/switch region; other site 981539005133 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 981539005134 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 981539005135 substrate binding pocket [chemical binding]; other site 981539005136 membrane-bound complex binding site; other site 981539005137 hinge residues; other site 981539005138 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 981539005139 dimer interface [polypeptide binding]; other site 981539005140 conserved gate region; other site 981539005141 putative PBP binding loops; other site 981539005142 ABC-ATPase subunit interface; other site 981539005143 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 981539005144 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 981539005145 dimer interface [polypeptide binding]; other site 981539005146 conserved gate region; other site 981539005147 putative PBP binding loops; other site 981539005148 ABC-ATPase subunit interface; other site 981539005149 Uncharacterized conserved protein [Function unknown]; Region: COG0398 981539005150 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 981539005151 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 981539005152 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 981539005153 dimer interface [polypeptide binding]; other site 981539005154 phosphorylation site [posttranslational modification] 981539005155 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 981539005156 ATP binding site [chemical binding]; other site 981539005157 Mg2+ binding site [ion binding]; other site 981539005158 G-X-G motif; other site 981539005159 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 981539005160 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 981539005161 active site 981539005162 phosphorylation site [posttranslational modification] 981539005163 intermolecular recognition site; other site 981539005164 dimerization interface [polypeptide binding]; other site 981539005165 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 981539005166 DNA binding site [nucleotide binding] 981539005167 Protein of unknown function (DUF3114); Region: DUF3114; pfam11311 981539005168 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3041 981539005169 RelB antitoxin; Region: RelB; cl01171 981539005170 probable dihydroxyacetone kinase regulator; Region: DHAK_reg; TIGR02366 981539005171 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 981539005172 myosin-cross-reactive antigen; Provisional; Region: PRK13977 981539005173 Sortase C (SrtC) or subfamily-3 sortases are membrane cysteine transpeptidases found in Gram-positive bacteria that anchor surface proteins to peptidoglycans of the bacterial cell wall envelope. This involves a transpeptidation reaction in which the...; Region: Sortase_C_3; cd05827 981539005174 active site 981539005175 catalytic site [active] 981539005176 fimbrial isopeptide formation D2 domain; Region: RrgB_K2N_iso_D2; TIGR04226 981539005177 Cna protein B-type domain; Region: Cna_B; pfam05738 981539005178 TQXA domain; Region: TQXA_dom; TIGR03934 981539005179 Repeat unit of collagen-binding protein domain B; Region: CollagenBindB; cd00222 981539005180 domain interaction interfaces [polypeptide binding]; other site 981539005181 Repeat unit of collagen-binding protein domain B; Region: CollagenBindB; cd00222 981539005182 domain interaction interfaces [polypeptide binding]; other site 981539005183 Repeat unit of collagen-binding protein domain B; Region: CollagenBindB; cd00222 981539005184 domain interaction interfaces [polypeptide binding]; other site 981539005185 Repeat unit of collagen-binding protein domain B; Region: CollagenBindB; cd00222 981539005186 domain interaction interfaces [polypeptide binding]; other site 981539005187 LPXTG-motif cell wall anchor domain; Region: LPXTG_anchor; TIGR01167 981539005188 LXG domain of WXG superfamily; Region: LXG; pfam04740 981539005189 type VII secretion effector, SACOL2603 family; Region: T7SS_SACOL2603; TIGR04197 981539005190 Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific...; Region: RICIN; cd00161 981539005191 Ricin-type beta-trefoil lectin domain; Region: Ricin_B_lectin; pfam00652 981539005192 putative sugar binding sites [chemical binding]; other site 981539005193 Q-X-W motif; other site 981539005194 threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK00413 981539005195 TGS _ThrRS_N: ThrRS (threonyl-tRNA Synthetase) is a class II tRNA synthetase that couples threonine to its cognate tRNA. In addition to its catalytic and anticodon-binding domains, ThrRS has an N-terminal TGS domain, named after the ThrRS, GTPase, and...; Region: TGS_ThrRS_N; cd01667 981539005196 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 981539005197 Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771 981539005198 active site 981539005199 dimer interface [polypeptide binding]; other site 981539005200 motif 1; other site 981539005201 motif 2; other site 981539005202 motif 3; other site 981539005203 ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860 981539005204 anticodon binding site; other site 981539005205 This family is most closely related to the GT1 family of glycosyltransferases. UDP-glucose-diacylglycerol glucosyltransferase (UGDG; also known as 1,2-diacylglycerol 3-glucosyltransferase) catalyzes the transfer of glucose from UDP-glucose to 1; Region: GT1_UGDG_like; cd03817 981539005206 Glycosyltransferase Family 4; Region: Glyco_transf_4; pfam13439 981539005207 putative ADP-binding pocket [chemical binding]; other site 981539005208 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 981539005209 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 981539005210 catabolite control protein A; Region: ccpA; TIGR01481 981539005211 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 981539005212 DNA binding site [nucleotide binding] 981539005213 domain linker motif; other site 981539005214 Ligand-binding domain of the catabolite control protein A (CcpA), which functions as the major transcriptional regulator of carbon catabolite repression/regulation; Region: PBP1_CcpA_like; cd06298 981539005215 dimerization interface [polypeptide binding]; other site 981539005216 effector binding site; other site 981539005217 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 981539005218 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 981539005219 Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092 981539005220 active site 981539005221 Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism]; Region: EmrE; COG2076 981539005222 NADH pyrophosphatase, a member of the Nudix hydrolase superfamily, catalyzes the cleavage of NADH into reduced nicotinamide mononucleotide (NMNH) and AMP. Like other members of the Nudix family, it requires a divalent cation, such as Mg2+ or Mn2+, for...; Region: NADH_pyrophosphatase; cd03429 981539005223 putative NADH binding site [chemical binding]; other site 981539005224 putative active site [active] 981539005225 nudix motif; other site 981539005226 putative metal binding site [ion binding]; other site 981539005227 DNA binding domain of tn916 integrase; Region: Integrase_DNA; pfam02920 981539005228 Tn1545-related conjugative transposon integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes bacterial (gram positive) and phage integrases, including those similar to Tn1545, Tn5252, and...; Region: INT_Tn1545_C; cd01199 981539005229 Int/Topo IB signature motif; other site 981539005230 Excisionase from transposon Tn916; Region: Tn916-Xis; pfam09035 981539005231 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 981539005232 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 981539005233 DNA binding residues [nucleotide binding] 981539005234 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 981539005235 non-specific DNA binding site [nucleotide binding]; other site 981539005236 salt bridge; other site 981539005237 sequence-specific DNA binding site [nucleotide binding]; other site 981539005238 Translation elongation factors (GTPases) [Translation, ribosomal structure and biogenesis]; Region: FusA; COG0480 981539005239 Tet(M)-like family includes Tet(M), Tet(O), Tet(W), and OtrA, containing tetracycline resistant proteins; Region: TetM_like; cd04168 981539005240 G1 box; other site 981539005241 putative GEF interaction site [polypeptide binding]; other site 981539005242 GTP/Mg2+ binding site [chemical binding]; other site 981539005243 Switch I region; other site 981539005244 G2 box; other site 981539005245 G3 box; other site 981539005246 Switch II region; other site 981539005247 G4 box; other site 981539005248 G5 box; other site 981539005249 Tet_II: This subfamily represents domain II of ribosomal protection proteins Tet(M) and Tet(O). This domain has homology to domain II of the elongation factors EF-G and EF-2. Tet(M) and Tet(O) catalyze the release of tetracycline (Tc) from the ribosome...; Region: Tet_II; cd03690 981539005250 EF-G_domain IV_RPP domain is a part of bacterial ribosomal protected proteins (RPP) family. RPPs such as tetracycline resistance proteins Tet(M) and Tet(O) mediate tetracycline resistance in both gram-positive and -negative species. Tetracyclines inhibit...; Region: Tet_like_IV; cd01684 981539005251 Tet_C: C-terminus of ribosomal protection proteins Tet(M) and Tet(O). This domain has homology to the C terminal domains of the elongation factors EF-G and EF-2. Tet(M) and Tet(O) catalyze the release of tetracycline (Tc) from the ribosome in a...; Region: Tet_C; cd03711 981539005252 Conjugative transposon protein TcpC; Region: TpcC; pfam12642 981539005253 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 981539005254 N-acetyl-D-glucosamine binding site [chemical binding]; other site 981539005255 catalytic residue [active] 981539005256 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 981539005257 NlpC/P60 family; Region: NLPC_P60; pfam00877 981539005258 ABC-2 family transporter protein; Region: ABC2_membrane_5; pfam13346 981539005259 Haemolysin-III related; Region: HlyIII; cl03831 981539005260 AAA-like domain; Region: AAA_10; pfam12846 981539005261 TcpE family; Region: TcpE; pfam12648 981539005262 Antirestriction protein (ArdA); Region: ArdA; pfam07275 981539005263 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 981539005264 non-specific DNA binding site [nucleotide binding]; other site 981539005265 salt bridge; other site 981539005266 sequence-specific DNA binding site [nucleotide binding]; other site 981539005267 Replication initiation factor; Region: Rep_trans; pfam02486 981539005268 DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674 981539005269 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 981539005270 Walker A motif; other site 981539005271 ATP binding site [chemical binding]; other site 981539005272 Walker B motif; other site 981539005273 arginine finger; other site 981539005274 Bacterial protein of unknown function (DUF961); Region: DUF961; pfam06125 981539005275 Bacterial protein of unknown function (DUF961); Region: DUF961; pfam06125 981539005276 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 981539005277 Sel1-like repeats; Region: SEL1; smart00671 981539005278 LPXTG-motif cell wall anchor domain; Region: LPXTG_anchor; TIGR01167 981539005279 PTS system, beta-glucoside-specific IIABC component; Region: PTS-II-ABC-beta; TIGR01995 981539005280 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 981539005281 active site turn [active] 981539005282 phosphorylation site [posttranslational modification] 981539005283 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 981539005284 Phosphotransferase system IIA components [Carbohydrate transport and metabolism]; Region: NagE; COG2190 981539005285 HPr interaction site; other site 981539005286 glycerol kinase (GK) interaction site [polypeptide binding]; other site 981539005287 active site 981539005288 phosphorylation site [posttranslational modification] 981539005289 Neutral/alkaline non-lysosomal ceramidase; Region: Ceramidase_alk; cl04712 981539005290 Neutral/alkaline non-lysosomal ceramidase; Region: Ceramidase_alk; cl04712 981539005291 Amidohydrolase; Region: Amidohydro_2; pfam04909 981539005292 Transcriptional regulator [Transcription]; Region: LysR; COG0583 981539005293 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 981539005294 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 981539005295 dimerization interface [polypeptide binding]; other site 981539005296 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Bacillus subtilis yoeA; Region: MATE_yoeA_like; cd13138 981539005297 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 981539005298 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028 981539005299 classical (c) SDRs; Region: SDR_c; cd05233 981539005300 NAD(P) binding site [chemical binding]; other site 981539005301 active site 981539005302 beta-phosphoglucomutase; Region: bPGM; TIGR01990 981539005303 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 981539005304 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 981539005305 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; cl07971 981539005306 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 981539005307 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; cl07971 981539005308 Poly(3-hydroxybutyrate) depolymerase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: LpqC; COG3509 981539005309 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 981539005310 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 981539005311 active site 981539005312 catalytic tetrad [active] 981539005313 MFS/sugar transport protein; Region: MFS_2; pfam13347 981539005314 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 981539005315 Amidohydrolase; Region: Amidohydro_2; pfam04909 981539005316 uncharacterized YdjC-like family proteins from bacteria; Region: YdjC_like_1; cd10805 981539005317 putative active site [active] 981539005318 YdjC motif; other site 981539005319 Mg binding site [ion binding]; other site 981539005320 putative homodimer interface [polypeptide binding]; other site 981539005321 PTS system, sucrose-specific IIBC component; Region: PTS-II-BC-sucr; TIGR01996 981539005322 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 981539005323 active site turn [active] 981539005324 phosphorylation site [posttranslational modification] 981539005325 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 981539005326 transcriptional antiterminator BglG; Provisional; Region: PRK09772 981539005327 CAT RNA binding domain; Region: CAT_RBD; smart01061 981539005328 PRD domain; Region: PRD; pfam00874 981539005329 PRD domain; Region: PRD; pfam00874 981539005330 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 981539005331 Sel1-like repeats; Region: SEL1; smart00671 981539005332 PTS system, sucrose-specific IIBC component; Region: PTS-II-BC-sucr; TIGR01996 981539005333 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 981539005334 active site turn [active] 981539005335 phosphorylation site [posttranslational modification] 981539005336 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 981539005337 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 981539005338 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 981539005339 SIS domain. SIS (Sugar ISomerase) domains are found in many phosphosugar isomerases and phosphosugar binding proteins. SIS domains are also found in proteins that regulate the expression of genes involved in synthesis of phosphosugars; Region: SIS; cl00389 981539005340 3-polyprenyl-4-hydroxybenzoate decarboxylase [Coenzyme metabolism]; Region: UbiX; COG0163 981539005341 Flavoprotein; Region: Flavoprotein; pfam02441 981539005342 3-octaprenyl-4-hydroxybenzoate carboxy-lyase; Region: UbiD; pfam01977 981539005343 Transcriptional regulator [Transcription]; Region: LysR; COG0583 981539005344 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 981539005345 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 981539005346 dimerization interface [polypeptide binding]; other site 981539005347 Protein of unknown function (DUF554); Region: DUF554; pfam04474 981539005348 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 981539005349 MarR family; Region: MarR_2; pfam12802 981539005350 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 981539005351 hydrophobic ligand binding site; other site 981539005352 NAD(P)H:FMN oxidoreductase family. This domain catalyzes the reduction of flavin, nitrocompound, quinones and azo compounds using NADH or NADPH as an electron donor. The enzyme is a homodimer, and each monomer binds a FMN as co-factor. This family...; Region: NfsB_like_nitroreductase; cd02149 981539005353 dimer interface [polypeptide binding]; other site 981539005354 FMN binding site [chemical binding]; other site 981539005355 Glycosyl hydrolase family 1; Region: Glyco_hydro_1; cl01046 981539005356 beta-galactosidase; Region: BGL; TIGR03356 981539005357 PTS system, beta-glucoside-specific IIABC component; Region: PTS-II-ABC-beta; TIGR01995 981539005358 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 981539005359 active site turn [active] 981539005360 phosphorylation site [posttranslational modification] 981539005361 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 981539005362 Phosphotransferase system IIA components [Carbohydrate transport and metabolism]; Region: NagE; COG2190 981539005363 HPr interaction site; other site 981539005364 glycerol kinase (GK) interaction site [polypeptide binding]; other site 981539005365 active site 981539005366 phosphorylation site [posttranslational modification] 981539005367 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 981539005368 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 981539005369 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 981539005370 putative active site [active] 981539005371 Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294 981539005372 SmpB-tmRNA interface; other site 981539005373 ribonuclease R; Region: RNase_R; TIGR02063 981539005374 Ribonuclease B OB domain; Region: OB_RNB; pfam08206 981539005375 RNB domain; Region: RNB; pfam00773 981539005376 S1_RNase_R: RNase R C-terminal S1 domain. RNase R is a processive 3' to 5' exoribonuclease, which is a homolog of RNase II. RNase R degrades RNA with secondary structure having a 3' overhang of at least 7 nucleotides. RNase R and PNPase...; Region: S1_RNase_R; cd04471 981539005377 RNA binding site [nucleotide binding]; other site 981539005378 preprotein translocase subunit SecG; Reviewed; Region: secG; PRK06870 981539005379 drug efflux system protein MdtG; Provisional; Region: PRK09874 981539005380 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 981539005381 putative substrate translocation pore; other site 981539005382 Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022 981539005383 Dephospho-CoA kinase [Coenzyme metabolism]; Region: CoaE; COG0237 981539005384 CoA-binding site [chemical binding]; other site 981539005385 formamidopyrimidine/5-formyluracil/ 5-hydroxymethyluracil DNA glycosylase; Validated; Region: PRK01103 981539005386 N-terminal domain of Escherichia coli Fpg1/MutM and related bacterial DNA glycosylases; Region: EcFpg-like_N; cd08966 981539005387 DNA binding site [nucleotide binding] 981539005388 catalytic residue [active] 981539005389 H2TH interface [polypeptide binding]; other site 981539005390 putative catalytic residues [active] 981539005391 turnover-facilitating residue; other site 981539005392 intercalation triad [nucleotide binding]; other site 981539005393 8OG recognition residue [nucleotide binding]; other site 981539005394 putative reading head residues; other site 981539005395 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 981539005396 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 981539005397 GTPase Era; Reviewed; Region: era; PRK00089 981539005398 E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163 981539005399 G1 box; other site 981539005400 GTP/Mg2+ binding site [chemical binding]; other site 981539005401 Switch I region; other site 981539005402 G2 box; other site 981539005403 Switch II region; other site 981539005404 G3 box; other site 981539005405 G4 box; other site 981539005406 G5 box; other site 981539005407 KH domain; Region: KH_2; pfam07650 981539005408 Diacylglycerol kinase [Cell envelope biogenesis, outer membrane]; Region: DgkA; COG0818 981539005409 metal-binding heat shock protein; Provisional; Region: PRK00016 981539005410 Alpha amylase catalytic domain found in bacterial Alpha-amylases (also called 1,4-alpha-D-glucan-4-glucanohydrolase); Region: AmyAc_bac1_AmyA; cd11315 981539005411 Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366 981539005412 active site 981539005413 Ca binding site [ion binding]; other site 981539005414 catalytic site [active] 981539005415 Aamy_C domain; Region: Aamy_C; smart00632 981539005416 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 981539005417 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 981539005418 Protein of unknown function (DUF3810); Region: DUF3810; pfam12725 981539005419 Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702 981539005420 PhoH-like protein; Region: PhoH; pfam02562 981539005421 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 981539005422 Major Facilitator Superfamily; Region: MFS_1; pfam07690 981539005423 putative substrate translocation pore; other site 981539005424 hypothetical protein; Provisional; Region: PRK13672 981539005425 methionine sulfoxide reductase A; Provisional; Region: PRK14054 981539005426 Predicted RNA-bindining protein (contains S1 and HTH domains) [General function prediction only]; Region: COG2996 981539005427 S1 domain; Region: S1_2; pfam13509 981539005428 Ribosomal protein S1-like RNA-binding domain; Region: S1; smart00316 981539005429 ribosome recycling factor; Reviewed; Region: frr; PRK00083 981539005430 Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation. Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520 981539005431 hinge region; other site 981539005432 UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254 981539005433 putative nucleotide binding site [chemical binding]; other site 981539005434 uridine monophosphate binding site [chemical binding]; other site 981539005435 homohexameric interface [polypeptide binding]; other site 981539005436 Ribosomal protein L1. The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA. In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403 981539005437 mRNA/rRNA interface [nucleotide binding]; other site 981539005438 50S ribosomal protein L11; Validated; Region: rplK; PRK00140 981539005439 Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349 981539005440 23S rRNA interface [nucleotide binding]; other site 981539005441 L7/L12 interface [polypeptide binding]; other site 981539005442 putative thiostrepton binding site; other site 981539005443 L25 interface [polypeptide binding]; other site 981539005444 Protein of unknown function (DUF3397); Region: DUF3397; pfam11877 981539005445 DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674 981539005446 4-hydroxybenzoate polyprenyltransferase and related prenyltransferases [Coenzyme metabolism]; Region: UbiA; cl00337 981539005447 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 981539005448 Ftsk gamma domain; Region: Ftsk_gamma; pfam09397 981539005449 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 981539005450 active site 981539005451 DNA binding site [nucleotide binding] 981539005452 Int/Topo IB signature motif; other site 981539005453 Sortase A (SrtA) or subfamily-1 sortases are cysteine transpeptidases found in gram-positive bacteria that anchor surface proteins to peptidoglycans of the bacterial cell wall envelope. They do so by catalyzing a transpeptidation reaction in which the...; Region: Sortase_A_1; cd06165 981539005454 active site 981539005455 catalytic site [active] 981539005456 CHAP domain; Region: CHAP; cl17642 981539005457 Cobalamin biosynthesis protein CobT (nicotinate-mononucleotide:5, 6-dimethylbenzimidazole phosphoribosyltransferase) [Coenzyme metabolism]; Region: CobT; COG4547 981539005458 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 981539005459 AAA-like domain; Region: AAA_10; pfam12846 981539005460 TcpE family; Region: TcpE; pfam12648 981539005461 Conjugative transposon protein TcpC; Region: TpcC; pfam12642 981539005462 Antirestriction protein (ArdA); Region: ArdA; cl01953 981539005463 HTH-like domain; Region: HTH_21; pfam13276 981539005464 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 981539005465 Integrase core domain; Region: rve; pfam00665 981539005466 Integrase core domain; Region: rve_2; pfam13333 981539005467 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 981539005468 Helix-turn-helix domain; Region: HTH_38; pfam13936 981539005469 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 981539005470 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 981539005471 non-specific DNA binding site [nucleotide binding]; other site 981539005472 salt bridge; other site 981539005473 sequence-specific DNA binding site [nucleotide binding]; other site 981539005474 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 981539005475 non-specific DNA binding site [nucleotide binding]; other site 981539005476 salt bridge; other site 981539005477 sequence-specific DNA binding site [nucleotide binding]; other site 981539005478 Replication initiation factor; Region: Rep_trans; pfam02486 981539005479 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 981539005480 putative cross-wall-targeting lipoprotein signal; Region: strep_RK_lipo; TIGR03726 981539005481 LPXTG-motif cell wall anchor domain; Region: LPXTG_anchor; TIGR01167 981539005482 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 981539005483 catalytic residues [active] 981539005484 Protein of unknown function DUF86; Region: DUF86; cl01031 981539005485 Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403 981539005486 active site 981539005487 NTP binding site [chemical binding]; other site 981539005488 metal binding triad [ion binding]; metal-binding site 981539005489 antibiotic binding site [chemical binding]; other site 981539005490 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 981539005491 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 981539005492 non-specific DNA binding site [nucleotide binding]; other site 981539005493 salt bridge; other site 981539005494 sequence-specific DNA binding site [nucleotide binding]; other site 981539005495 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3666 981539005496 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 981539005497 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 981539005498 RelB antitoxin; Region: RelB; cl01171 981539005499 pyridine nucleotide-disulfide oxidoreductase; Provisional; Region: PRK07251 981539005500 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 981539005501 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 981539005502 oxalate/formate antiporter family transporter; Region: 2A0111; TIGR00890 981539005503 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 981539005504 putative substrate translocation pore; other site 981539005505 Peptidyl-prolyl cis-trans isomerase (rotamase) - cyclophilin family [Posttranslational modification, protein turnover, chaperones]; Region: PpiB; COG0652 981539005506 active site 981539005507 Mn-dependent transcriptional regulator [Transcription]; Region: TroR; COG1321 981539005508 Iron dependent repressor, N-terminal DNA binding domain; Region: Fe_dep_repress; pfam01325 981539005509 Iron dependent repressor, metal binding and dimerisation domain; Region: Fe_dep_repr_C; pfam02742 981539005510 FeoA domain; Region: FeoA; pfam04023 981539005511 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Validated; Region: PRK05584 981539005512 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Region: MTA/SAH-Nsdase; TIGR01704 981539005513 DNA-directed RNA polymerase subunit B'; Validated; Region: PRK07225 981539005514 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 981539005515 dimer interface [polypeptide binding]; other site 981539005516 ADP-ribose binding site [chemical binding]; other site 981539005517 active site 981539005518 nudix motif; other site 981539005519 metal binding site [ion binding]; metal-binding site 981539005520 bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase; Provisional; Region: glmU; PRK14354 981539005521 N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540 981539005522 Substrate binding site; other site 981539005523 Mg++ binding site; other site 981539005524 N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353 981539005525 active site 981539005526 substrate binding site [chemical binding]; other site 981539005527 CoA binding site [chemical binding]; other site 981539005528 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 981539005529 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 981539005530 ASC-1 homology domain, subfamily similar to Enterococcus faecalis Ef3133. The ASCH domain, a small beta-barrel domain found in all three kingdoms of life, resembles the RNA-binding PUA domain and may also interact with RNA. ASCH has been proposed to...; Region: ASCH_Ef3133_like; cd06553 981539005531 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK06550 981539005532 classical (c) SDRs; Region: SDR_c; cd05233 981539005533 NAD(P) binding site [chemical binding]; other site 981539005534 active site 981539005535 Protein of unknown function (DUF2829); Region: DUF2829; pfam11195 981539005536 hypothetical protein; Validated; Region: PRK07668 981539005537 Predicted transcriptional regulators [Transcription]; Region: COG1695 981539005538 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 981539005539 FemAB family; Region: FemAB; pfam02388 981539005540 methionyl-tRNA synthetase; Reviewed; Region: PRK12267 981539005541 catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814 981539005542 active site 981539005543 HIGH motif; other site 981539005544 KMSKS motif; other site 981539005545 Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957 981539005546 tRNA binding surface [nucleotide binding]; other site 981539005547 anticodon binding site; other site 981539005548 tRNA-binding-domain-containing Escherichia coli methionyl-tRNA synthetase (EcMetRS)-like proteins. This family includes EcMetRS and Aquifex aeolicus Trbp111 (AaTrbp111). This domain has general tRNA binding properties. MetRS aminoacylates methionine...; Region: tRNA_bind_EcMetRS_like; cd02800 981539005549 dimer interface [polypeptide binding]; other site 981539005550 putative tRNA-binding site [nucleotide binding]; other site 981539005551 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 981539005552 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Thermotoga marina NorM; Region: MATE_NorM_like; cd13137 981539005553 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 981539005554 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 981539005555 Human Ape1-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: Ape1-like_AP-endo; cd09087 981539005556 active site 981539005557 putative catalytic site [active] 981539005558 DNA binding site [nucleotide binding] 981539005559 putative phosphate binding site [ion binding]; other site 981539005560 metal binding site A [ion binding]; metal-binding site 981539005561 AP binding site [nucleotide binding]; other site 981539005562 metal binding site B [ion binding]; metal-binding site 981539005563 Major Facilitator Superfamily; Region: MFS_1; pfam07690 981539005564 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 981539005565 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 981539005566 SnoaL-like domain; Region: SnoaL_3; pfam13474 981539005567 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 981539005568 active site 981539005569 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 981539005570 catalytic tetrad [active] 981539005571 short chain dehydrogenase; Provisional; Region: PRK06940 981539005572 classical (c) SDRs; Region: SDR_c; cd05233 981539005573 NAD(P) binding site [chemical binding]; other site 981539005574 active site 981539005575 Transcriptional regulator [Transcription]; Region: LysR; COG0583 981539005576 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 981539005577 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 981539005578 dimerization interface [polypeptide binding]; other site 981539005579 Arsenate Reductase (ArsC) family, unknown subfamily; uncharacterized proteins containing a CXXC motif with similarity to thioredoxin (TRX)-fold arsenic reductases, ArsC. Proteins containing a redox active CXXC motif like TRX and glutaredoxin (GRX)...; Region: ArsC_like; cd03036 981539005580 ArsC family; Region: ArsC; pfam03960 981539005581 putative ArsC-like catalytic residues; other site 981539005582 putative TRX-like catalytic residues [active] 981539005583 Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350 981539005584 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 981539005585 DNA binding site [nucleotide binding] 981539005586 active site 981539005587 Putative D-3-Phosphoglycerate Dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_like_3; cd12174 981539005588 D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain; Region: 2-Hacid_dh; pfam00389 981539005589 putative ligand binding site [chemical binding]; other site 981539005590 putative NAD binding site [chemical binding]; other site 981539005591 putative catalytic site [active] 981539005592 C-terminal ACT (regulatory) domain of D-3-Phosphoglycerate Dehydrogenase (3PGDH) found in fungi and bacteria; Region: ACT_3PGDH; cd04901 981539005593 L-serine binding site [chemical binding]; other site 981539005594 ACT domain interface; other site 981539005595 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 981539005596 3-phosphoserine/phosphohydroxythreonine aminotransferase; Provisional; Region: PRK05355 981539005597 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 981539005598 catalytic residue [active] 981539005599 Uncharacterized protein involved in copper resistance [Inorganic ion transport and metabolism]; Region: CutC; COG3142 981539005600 Nitrogen regulatory protein PII [Amino acid transport and metabolism]; Region: GlnK; COG0347 981539005601 Nitrogen regulatory protein P-II; Region: P-II; smart00938 981539005602 Ammonia permease [Inorganic ion transport and metabolism]; Region: AmtB; COG0004 981539005603 Predicted methyltransferases [General function prediction only]; Region: COG0313 981539005604 Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648 981539005605 putative SAM binding site [chemical binding]; other site 981539005606 putative homodimer interface [polypeptide binding]; other site 981539005607 DNA replication intiation control protein YabA; Reviewed; Region: PRK13169 981539005608 Uncharacterized homolog of PSP1 [Function unknown]; Region: COG1774 981539005609 DNA polymerase III subunit delta'; Validated; Region: PRK07276 981539005610 DNA polymerase III subunit delta'; Validated; Region: PRK08485 981539005611 thymidylate kinase; Validated; Region: tmk; PRK00698 981539005612 Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672 981539005613 TMP-binding site; other site 981539005614 ATP-binding site [chemical binding]; other site 981539005615 FOG: CBS domain [General function prediction only]; Region: COG0517 981539005616 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the acetoin utilization proteins in bacteria. Acetoin is a product of fermentative metabolism in many prokaryotic and eukaryotic microorganisms. They produce...; Region: CBS_pair_ACT_assoc2; cd04585 981539005617 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cd02116 981539005618 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 981539005619 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 981539005620 Walker A/P-loop; other site 981539005621 ATP binding site [chemical binding]; other site 981539005622 Q-loop/lid; other site 981539005623 ABC transporter signature motif; other site 981539005624 Walker B; other site 981539005625 D-loop; other site 981539005626 H-loop/switch region; other site 981539005627 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 981539005628 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 981539005629 Walker A/P-loop; other site 981539005630 ATP binding site [chemical binding]; other site 981539005631 Q-loop/lid; other site 981539005632 ABC transporter signature motif; other site 981539005633 Walker B; other site 981539005634 D-loop; other site 981539005635 H-loop/switch region; other site 981539005636 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 981539005637 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 981539005638 TM-ABC transporter signature motif; other site 981539005639 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 981539005640 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 981539005641 TM-ABC transporter signature motif; other site 981539005642 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 981539005643 Type I periplasmic ligand-binding domain of uncharacterized ABC (Atpase Binding Cassette)-type active transport systems that are predicted to be involved in uptake of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_ligand_binding_like_12; cd06347 981539005644 putative ligand binding site [chemical binding]; other site 981539005645 hypothetical protein; Provisional; Region: PRK02302 981539005646 Protein of unknown function (DUF964); Region: DUF964; pfam06133 981539005647 Protease subunit of ATP-dependent Clp proteases [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: ClpP; COG0740 981539005648 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 981539005649 oligomer interface [polypeptide binding]; other site 981539005650 active site residues [active] 981539005651 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 981539005652 EamA-like transporter family; Region: EamA; pfam00892 981539005653 Transcriptional regulator [Transcription]; Region: LysR; COG0583 981539005654 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 981539005655 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 981539005656 dimerization interface [polypeptide binding]; other site 981539005657 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 981539005658 active site 981539005659 Bifunctional PLP-dependent enzyme with beta-cystathionase and maltose regulon repressor activities [Amino acid transport and metabolism]; Region: MalY; COG1168 981539005660 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 981539005661 pyridoxal 5'-phosphate binding site [chemical binding]; other site 981539005662 homodimer interface [polypeptide binding]; other site 981539005663 catalytic residue [active] 981539005664 cystathionine gamma-synthase; Reviewed; Region: PRK07269 981539005665 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 981539005666 homodimer interface [polypeptide binding]; other site 981539005667 substrate-cofactor binding pocket; other site 981539005668 pyridoxal 5'-phosphate binding site [chemical binding]; other site 981539005669 catalytic residue [active] 981539005670 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 981539005671 Stage V sporulation protein B, also known as Stage III sporulation protein F, and related proteins; Region: MATE_SpoVB_like; cd13124 981539005672 UDP-N-acetylmuramoylalanyl-D-glutamate--L-lysine ligase; Provisional; Region: PRK14022 981539005673 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 981539005674 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 981539005675 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 981539005676 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 981539005677 Walker A/P-loop; other site 981539005678 ATP binding site [chemical binding]; other site 981539005679 Q-loop/lid; other site 981539005680 ABC transporter signature motif; other site 981539005681 Walker B; other site 981539005682 D-loop; other site 981539005683 H-loop/switch region; other site 981539005684 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 981539005685 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 981539005686 intersubunit interface [polypeptide binding]; other site 981539005687 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 981539005688 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 981539005689 ABC-ATPase subunit interface; other site 981539005690 dimer interface [polypeptide binding]; other site 981539005691 putative PBP binding regions; other site 981539005692 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 981539005693 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 981539005694 ABC-ATPase subunit interface; other site 981539005695 dimer interface [polypeptide binding]; other site 981539005696 putative PBP binding regions; other site 981539005697 Domain of unknown function (DUF1803); Region: DUF1803; pfam08820 981539005698 Domain of unknown function (DUF1803); Region: DUF1803; pfam08820 981539005699 Orthopoxvirus protein of unknown function (DUF830); Region: DUF830; pfam05708 981539005700 hypothetical protein; Validated; Region: PRK02101 981539005701 putative manganese-dependent inorganic pyrophosphatase; Provisional; Region: PRK05427 981539005702 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 981539005703 DHHA2 domain; Region: DHHA2; pfam02833 981539005704 pyruvate formate-lyase 1-activating enzyme; Region: PFLA; TIGR02493 981539005705 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 981539005706 FeS/SAM binding site; other site 981539005707 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 981539005708 Domain of unknown function DUF21; Region: DUF21; pfam01595 981539005709 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 981539005710 Transporter associated domain; Region: CorC_HlyC; smart01091 981539005711 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 981539005712 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 981539005713 Walker A/P-loop; other site 981539005714 ATP binding site [chemical binding]; other site 981539005715 Q-loop/lid; other site 981539005716 ABC transporter signature motif; other site 981539005717 Walker B; other site 981539005718 D-loop; other site 981539005719 H-loop/switch region; other site 981539005720 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 981539005721 Putative rRNA methylase; Region: rRNA_methylase; pfam06962 981539005722 Predicted Fe-S oxidoreductase [General function prediction only]; Region: COG1242 981539005723 PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392 981539005724 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 981539005725 active site 981539005726 Predicted membrane protein [Function unknown]; Region: COG2510 981539005727 Predicted membrane protein [Function unknown]; Region: COG3601 981539005728 Protein of unknown function (DUF3816); Region: DUF3816; pfam12822 981539005729 Predicted rRNA methylase (SpoU class) [Translation, ribosomal structure and biogenesis]; Region: CspR; COG0219 981539005730 short chain dehydrogenase; Provisional; Region: PRK07454 981539005731 classical (c) SDRs; Region: SDR_c; cd05233 981539005732 NAD(P) binding site [chemical binding]; other site 981539005733 active site 981539005734 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 981539005735 Helix-Turn-Helix DNA binding domain of the MerR-like transcription regulators YyaN and YraB; Region: HTH_YyaN; cd01109 981539005736 DNA binding residues [nucleotide binding] 981539005737 putative dimer interface [polypeptide binding]; other site 981539005738 truncated amino acid/polyamine transport protein 981539005739 truncated amino acid/polyamine transport protein 981539005740 potassium transporter peripheral membrane component; Reviewed; Region: trkA; PRK09496 981539005741 TrkA-N domain; Region: TrkA_N; pfam02254 981539005742 TrkA-C domain; Region: TrkA_C; pfam02080 981539005743 TrkA-N domain; Region: TrkA_N; pfam02254 981539005744 TrkA-C domain; Region: TrkA_C; pfam02080 981539005745 Trk-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: TrkG; COG0168 981539005746 potassium uptake protein, TrkH family; Region: 2a38; TIGR00933 981539005747 hypothetical protein; Validated; Region: PRK00041 981539005748 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 981539005749 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 981539005750 RNA binding surface [nucleotide binding]; other site 981539005751 Pseudouridine synthases, RsuA subfamily; Region: PseudoU_synth_RsuA_like; cd02870 981539005752 active site 981539005753 segregation and condensation protein B; Reviewed; Region: scpB; PRK00135 981539005754 segregation and condensation protein A; Reviewed; Region: scpA; PRK00104 981539005755 site-specific tyrosine recombinase XerD-like protein; Reviewed; Region: xerD; PRK02436 981539005756 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 981539005757 active site 981539005758 Int/Topo IB signature motif; other site 981539005759 catalytic residues [active] 981539005760 DNA binding site [nucleotide binding] 981539005761 FOG: CBS domain [General function prediction only]; Region: COG0517 981539005762 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_30; cd04643 981539005763 Escherichia coli YfcE and related proteins, metallophosphatase domain; Region: MPP_YfcE; cd00841 981539005764 active site 981539005765 metal binding site [ion binding]; metal-binding site 981539005766 homotetramer interface [polypeptide binding]; other site 981539005767 putative deoxyribonucleotide triphosphate pyrophosphatase/unknown domain fusion protein; Reviewed; Region: PRK02491 981539005768 NTPase/HAM1. This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515 981539005769 active site 981539005770 dimerization interface [polypeptide binding]; other site 981539005771 glutamate racemase; Provisional; Region: PRK00865 981539005772 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3763 981539005773 Diaminopimelate decarboxylase [Amino acid transport and metabolism]; Region: LysA; COG0019 981539005774 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828 981539005775 active site 981539005776 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 981539005777 substrate binding site [chemical binding]; other site 981539005778 catalytic residues [active] 981539005779 dimer interface [polypeptide binding]; other site 981539005780 Integral membrane protein, interacts with FtsH [General function prediction only]; Region: COG0670 981539005781 Bacterial BAX inhibitor (BI)-1/YccA-like proteins; Region: BI-1-like_bacterial; cd10432 981539005782 Predicted HD superfamily hydrolase [General function prediction only]; Region: COG1418 981539005783 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 981539005784 Zn2+ binding site [ion binding]; other site 981539005785 Mg2+ binding site [ion binding]; other site 981539005786 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 981539005787 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; smart00967 981539005788 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 981539005789 acylphosphatase; Provisional; Region: PRK14434 981539005790 OxaA-like protein precursor; Provisional; Region: PRK02463 981539005791 membrane protein insertase, YidC/Oxa1 family, C-terminal domain; Region: yidC_oxa1_cterm; TIGR03592 981539005792 transcription elongation factor GreA; Reviewed; Region: greA; PRK00226 981539005793 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 981539005794 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 981539005795 YceG-like family; Region: YceG; pfam02618 981539005796 proteins similar to Escherichia coli yceG; Region: yceG_like; cd08010 981539005797 dimerization interface [polypeptide binding]; other site 981539005798 Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247 981539005799 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 981539005800 Coenzyme A binding pocket [chemical binding]; other site 981539005801 UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421 981539005802 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 981539005803 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 981539005804 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 981539005805 Bacterial SNF2 helicase associated; Region: SNF2_assoc; pfam08455 981539005806 SNF2 family N-terminal domain; Region: SNF2_N; pfam00176 981539005807 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 981539005808 ATP binding site [chemical binding]; other site 981539005809 putative Mg++ binding site [ion binding]; other site 981539005810 Superfamily II DNA and RNA helicases [DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis]; Region: SrmB; COG0513 981539005811 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 981539005812 nucleotide binding region [chemical binding]; other site 981539005813 ATP-binding site [chemical binding]; other site 981539005814 GTP-binding protein Der; Reviewed; Region: PRK00093 981539005815 EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894 981539005816 G1 box; other site 981539005817 GTP/Mg2+ binding site [chemical binding]; other site 981539005818 Switch I region; other site 981539005819 G2 box; other site 981539005820 Switch II region; other site 981539005821 G3 box; other site 981539005822 G4 box; other site 981539005823 G5 box; other site 981539005824 EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895 981539005825 G1 box; other site 981539005826 GTP/Mg2+ binding site [chemical binding]; other site 981539005827 Switch I region; other site 981539005828 G2 box; other site 981539005829 G3 box; other site 981539005830 Switch II region; other site 981539005831 G4 box; other site 981539005832 G5 box; other site 981539005833 primosomal protein DnaI; Reviewed; Region: PRK08939 981539005834 Primosomal protein DnaI N-terminus; Region: DnaI_N; pfam07319 981539005835 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 981539005836 Walker A motif; other site 981539005837 ATP binding site [chemical binding]; other site 981539005838 Walker B motif; other site 981539005839 Replication initiation/membrane attachment protein [DNA replication, recombination, and repair]; Region: DnaB; COG3611 981539005840 Replication initiation and membrane attachment; Region: DnaB_2; cl12121 981539005841 transcriptional regulator NrdR; Validated; Region: nrdR; PRK00464 981539005842 ATP cone domain; Region: ATP-cone; pfam03477 981539005843 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 981539005844 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 981539005845 dimerization interface [polypeptide binding]; other site 981539005846 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 981539005847 dimer interface [polypeptide binding]; other site 981539005848 phosphorylation site [posttranslational modification] 981539005849 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 981539005850 ATP binding site [chemical binding]; other site 981539005851 Mg2+ binding site [ion binding]; other site 981539005852 G-X-G motif; other site 981539005853 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 981539005854 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 981539005855 active site 981539005856 phosphorylation site [posttranslational modification] 981539005857 intermolecular recognition site; other site 981539005858 dimerization interface [polypeptide binding]; other site 981539005859 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 981539005860 DNA binding site [nucleotide binding] 981539005861 Predicted metal-binding, possibly nucleic acid-binding protein [General function prediction only]; Region: COG1399 981539005862 heat shock protein HtpX; Provisional; Region: PRK04897 981539005863 Uncharacterized conserved protein [Function unknown]; Region: LemA; COG1704 981539005864 Predicted S-adenosylmethionine-dependent methyltransferase involved in bacterial cell division [Cell envelope biogenesis, outer membrane]; Region: GidB; COG0357 981539005865 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 981539005866 S-adenosylmethionine binding site [chemical binding]; other site 981539005867 Trk-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: TrkG; COG0168 981539005868 potassium uptake protein, TrkH family; Region: 2a38; TIGR00933 981539005869 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 981539005870 TrkA-N domain; Region: TrkA_N; pfam02254 981539005871 TrkA-C domain; Region: TrkA_C; pfam02080 981539005872 ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619 981539005873 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 981539005874 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 981539005875 Walker A/P-loop; other site 981539005876 ATP binding site [chemical binding]; other site 981539005877 Q-loop/lid; other site 981539005878 ABC transporter signature motif; other site 981539005879 Walker B; other site 981539005880 D-loop; other site 981539005881 H-loop/switch region; other site 981539005882 ATP-binding cassette cobalt transporter; Region: DUF3744; pfam12558 981539005883 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 981539005884 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 981539005885 Walker A/P-loop; other site 981539005886 ATP binding site [chemical binding]; other site 981539005887 Q-loop/lid; other site 981539005888 ABC transporter signature motif; other site 981539005889 Walker B; other site 981539005890 D-loop; other site 981539005891 H-loop/switch region; other site 981539005892 hypothetical protein; Provisional; Region: PRK13661 981539005893 Uncharacterized conserved protein [Function unknown]; Region: COG1912 981539005894 serine/threonine transporter SstT; Provisional; Region: PRK13628 981539005895 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 981539005896 Branched-chain amino acid transport protein; Region: Branch_AA_trans; cl00547 981539005897 biliverdin IX beta reductase (BVR-B, aka flavin reductase)-like proteins; atypical (a) SDRs; Region: BVR-B_like_SDR_a; cd05244 981539005898 NADH(P)-binding; Region: NAD_binding_10; pfam13460 981539005899 NAD binding site [chemical binding]; other site 981539005900 substrate binding site [chemical binding]; other site 981539005901 putative active site [active] 981539005902 Predicted transcriptional regulator [Transcription]; Region: COG1959 981539005903 Transcriptional regulator; Region: Rrf2; pfam02082 981539005904 Transcriptional regulator; Region: Rrf2; cl17282 981539005905 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 981539005906 dimer interface [polypeptide binding]; other site 981539005907 conserved gate region; other site 981539005908 ABC-ATPase subunit interface; other site 981539005909 ABC-type metal ion transport system, ATPase component [Inorganic ion transport and metabolism]; Region: AbcC; COG1135 981539005910 ATP-binding cassette domain of methionine transporter; Region: ABC_MetN_methionine_transporter; cd03258 981539005911 Walker A/P-loop; other site 981539005912 ATP binding site [chemical binding]; other site 981539005913 Q-loop/lid; other site 981539005914 ABC transporter signature motif; other site 981539005915 Walker B; other site 981539005916 D-loop; other site 981539005917 H-loop/switch region; other site 981539005918 NIL domain; Region: NIL; pfam09383 981539005919 hypothetical protein; Provisional; Region: PRK06446 981539005920 Uncharacterized M20 Dipeptidases; Region: M20_dipept_like_4; cd05681 981539005921 metal binding site [ion binding]; metal-binding site 981539005922 dimer interface [polypeptide binding]; other site 981539005923 ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464 981539005924 NLPA lipoprotein; Region: Lipoprotein_9; pfam03180 981539005925 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 981539005926 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 981539005927 substrate binding pocket [chemical binding]; other site 981539005928 membrane-bound complex binding site; other site 981539005929 hinge residues; other site 981539005930 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 981539005931 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 981539005932 metal binding site [ion binding]; metal-binding site 981539005933 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 981539005934 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 981539005935 substrate binding pocket [chemical binding]; other site 981539005936 membrane-bound complex binding site; other site 981539005937 hinge residues; other site 981539005938 Peptidase C26; Region: Peptidase_C26; pfam07722 981539005939 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_2; cd01745 981539005940 catalytic triad [active] 981539005941 hypothetical protein; Provisional; Region: PRK12378 981539005942 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 981539005943 active site turn [active] 981539005944 phosphorylation site [posttranslational modification] 981539005945 PTS system, glucose-like IIB component; Region: EIIB_glc; TIGR00826 981539005946 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 981539005947 Phosphotransferase system, EIIC; Region: PTS_EIIC; pfam02378 981539005948 Glycosyl hydrolase family 1; Region: Glyco_hydro_1; cl01046 981539005949 beta-galactosidase; Region: BGL; TIGR03356 981539005950 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 981539005951 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 981539005952 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 981539005953 putative active site [active] 981539005954 NmrA-like family; Region: NmrA; pfam05368 981539005955 triphenylmethane reductase (TMR)-like proteins, NMRa-like, atypical (a) SDRs; Region: TMR_SDR_a; cd05269 981539005956 NADP binding site [chemical binding]; other site 981539005957 Helix-Turn-Helix DNA binding domain of the transcription regulators TipAL, Mta, and SkgA; Region: HTH_TipAL-Mta; cd01106 981539005958 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 981539005959 DNA binding residues [nucleotide binding] 981539005960 dimer interface [polypeptide binding]; other site 981539005961 TipAS antibiotic-recognition domain; Region: TipAS; pfam07739 981539005962 hypothetical protein; Provisional; Region: PRK13670 981539005963 HIGH Nucleotidyl Transferase; Region: HIGH_NTase1; pfam05636 981539005964 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 981539005965 ATP binding site [chemical binding]; other site 981539005966 putative Mg++ binding site [ion binding]; other site 981539005967 helicase superfamily c-terminal domain; Region: HELICc; smart00490 981539005968 nucleotide binding region [chemical binding]; other site 981539005969 ATP-binding site [chemical binding]; other site 981539005970 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 981539005971 S-adenosylmethionine binding site [chemical binding]; other site 981539005972 Uncharacterized homolog of plant Iojap protein [Function unknown]; Region: COG0799 981539005973 Isochorismatase family; Region: Isochorismatase; pfam00857 981539005974 Nicotinamidase_ related amidohydrolases. Cysteine hydrolases of unknown function that share the catalytic triad with other amidohydrolases, like nicotinamidase, which converts nicotinamide to nicotinic acid and ammonia; Region: nicotinamidase_related; cd01014 981539005975 catalytic triad [active] 981539005976 conserved cis-peptide bond; other site 981539005977 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 981539005978 Zn2+ binding site [ion binding]; other site 981539005979 Mg2+ binding site [ion binding]; other site 981539005980 nicotinic acid mononucleotide adenylyltransferase; Provisional; Region: nadD; PRK00071 981539005981 Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165 981539005982 active site 981539005983 (T/H)XGH motif; other site 981539005984 Predicted RNA-binding protein containing KH domain, possibly ribosomal protein [Translation, ribosomal structure and biogenesis]; Region: COG1534 981539005985 GTPase YqeH; Provisional; Region: PRK13796 981539005986 Circularly permuted YqeH GTPase; Region: YqeH; cd01855 981539005987 GTP/Mg2+ binding site [chemical binding]; other site 981539005988 G4 box; other site 981539005989 G5 box; other site 981539005990 G1 box; other site 981539005991 Switch I region; other site 981539005992 G2 box; other site 981539005993 G3 box; other site 981539005994 Switch II region; other site 981539005995 Predicted hydrolase of the HAD superfamily [General function prediction only]; Region: COG2179 981539005996 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 981539005997 active site 981539005998 motif I; other site 981539005999 motif II; other site 981539006000 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 981539006001 Major Facilitator Superfamily; Region: MFS_1; pfam07690 981539006002 putative substrate translocation pore; other site 981539006003 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 981539006004 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 981539006005 MarR family; Region: MarR_2; pfam12802 981539006006 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 981539006007 EamA-like transporter family; Region: EamA; pfam00892 981539006008 aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477 981539006009 GatB/GatE catalytic domain; Region: GatB_N; pfam02934 981539006010 GatB domain; Region: GatB_Yqey; pfam02637 981539006011 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 981539006012 aspartyl/glutamyl-tRNA amidotransferase subunit A; Reviewed; Region: gatA; PRK00012 981539006013 aspartyl/glutamyl-tRNA amidotransferase subunit C; Reviewed; Region: gatC; PRK00034 981539006014 Isochorismatase family; Region: Isochorismatase; pfam00857 981539006015 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 981539006016 catalytic triad [active] 981539006017 conserved cis-peptide bond; other site 981539006018 transcriptional repressor CodY; Validated; Region: PRK04158 981539006019 CodY GAF-like domain; Region: CodY; pfam06018 981539006020 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 981539006021 dimerization interface [polypeptide binding]; other site 981539006022 putative Zn2+ binding site [ion binding]; other site 981539006023 putative DNA binding site [nucleotide binding]; other site 981539006024 aminotransferase AlaT; Validated; Region: PRK09265 981539006025 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 981539006026 pyridoxal 5'-phosphate binding site [chemical binding]; other site 981539006027 homodimer interface [polypeptide binding]; other site 981539006028 catalytic residue [active] 981539006029 Membrane domain of glycerophosphoryl diester phosphodiesterase; Region: GPDPase_memb; cl01974 981539006030 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 981539006031 Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily; Region: PI-PLCc_GDPD_SF; cl14615 981539006032 active site 981539006033 catalytic site [active] 981539006034 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 981539006035 Ligand Binding Site [chemical binding]; other site 981539006036 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 981539006037 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 981539006038 active site 981539006039 motif I; other site 981539006040 motif II; other site 981539006041 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 981539006042 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 981539006043 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4696 981539006044 metal binding site [ion binding]; metal-binding site 981539006045 Type II (periplasmic) bacterial L-asparaginase; Region: L-asparaginase_II; cd08964 981539006046 active site 981539006047 homotetramer interface [polypeptide binding]; other site 981539006048 homodimer interface [polypeptide binding]; other site 981539006049 Predicted transcriptional regulator [Transcription]; Region: COG3655 981539006050 sequence-specific DNA binding site [nucleotide binding]; other site 981539006051 salt bridge; other site 981539006052 ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917 981539006053 RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488 981539006054 generic binding surface II; other site 981539006055 ssDNA binding site; other site 981539006056 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 981539006057 ATP binding site [chemical binding]; other site 981539006058 putative Mg++ binding site [ion binding]; other site 981539006059 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 981539006060 nucleotide binding region [chemical binding]; other site 981539006061 ATP-binding site [chemical binding]; other site 981539006062 alanine racemase; Reviewed; Region: alr; PRK00053 981539006063 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430 981539006064 active site 981539006065 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 981539006066 dimer interface [polypeptide binding]; other site 981539006067 substrate binding site [chemical binding]; other site 981539006068 catalytic residues [active] 981539006069 4'-phosphopantetheinyl transferase; Provisional; Region: acpS; PRK00070 981539006070 3-deoxy-D-arabino-heptulosonate 7-phosphate (DAHP) synthase [Amino acid transport and metabolism]; Region: AroG; cl17260 981539006071 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 981539006072 3-deoxy-D-arabino-heptulosonate 7-phosphate (DAHP) synthase [Amino acid transport and metabolism]; Region: AroG; COG0722 981539006073 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 981539006074 preprotein translocase subunit SecA; Reviewed; Region: PRK12904 981539006075 SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958 981539006076 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 981539006077 nucleotide binding region [chemical binding]; other site 981539006078 ATP-binding site [chemical binding]; other site 981539006079 SEC-C motif; Region: SEC-C; pfam02810 981539006080 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 981539006081 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 981539006082 nucleotide binding site [chemical binding]; other site 981539006083 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 981539006084 PTS system, sucrose-specific IIBC component; Region: PTS-II-BC-sucr; TIGR01996 981539006085 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 981539006086 active site turn [active] 981539006087 phosphorylation site [posttranslational modification] 981539006088 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 981539006089 PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_glc; cd00210 981539006090 HPr interaction site; other site 981539006091 glycerol kinase (GK) interaction site [polypeptide binding]; other site 981539006092 active site 981539006093 phosphorylation site [posttranslational modification] 981539006094 sucrose-6-phosphate hydrolase; Region: scrB_fam; TIGR01322 981539006095 Glycosyl hydrolase family 32, beta-fructosidases; Region: GH32_B_Fructosidase; cd08996 981539006096 substrate binding [chemical binding]; other site 981539006097 active site 981539006098 Glycosyl hydrolases family 32 C terminal; Region: Glyco_hydro_32C; pfam08244 981539006099 Transcriptional regulators [Transcription]; Region: PurR; COG1609 981539006100 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 981539006101 DNA binding site [nucleotide binding] 981539006102 domain linker motif; other site 981539006103 Ligand binding domain of the lacI-like transcription regulator from a novel metal-reducing bacterium Alkaliphilus Metalliredigens (strain Qymf) and its close homologs; Region: PBP1_Qymf_like; cd06291 981539006104 dimerization interface [polypeptide binding]; other site 981539006105 ligand binding site [chemical binding]; other site 981539006106 sodium binding site [ion binding]; other site 981539006107 transcription antitermination protein NusB; Reviewed; Region: nusB; PRK00202 981539006108 putative RNA binding site [nucleotide binding]; other site 981539006109 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1302 981539006110 elongation factor P; Validated; Region: PRK00529 981539006111 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 981539006112 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 981539006113 RNA binding site [nucleotide binding]; other site 981539006114 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 981539006115 RNA binding site [nucleotide binding]; other site 981539006116 Protein of unknown function (DUF2628); Region: DUF2628; pfam10947 981539006117 Tim44-like domain; Region: Tim44; cl09208 981539006118 Deoxycytidylate deaminase domain. Deoxycytidylate deaminase catalyzes the deamination of dCMP to dUMP, providing the nucleotide substrate for thymidylate synthase. The enzyme binds Zn++, which is required for catalytic activity. The activity of the...; Region: deoxycytidylate_deaminase; cd01286 981539006119 catalytic motif [active] 981539006120 Zn binding site [ion binding]; other site 981539006121 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 981539006122 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 981539006123 Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092 981539006124 active site 981539006125 Superinfection immunity protein; Region: Imm_superinfect; pfam14373 981539006126 PASTA domain. This domain is found at the C-termini of several Penicillin-binding proteins (PBPs) and bacterial serine/threonine kinases. It is a small globular fold consisting of 3 beta-sheets and an alpha-helix. The name PASTA is derived from PBP and...; Region: PASTA; cl02768 981539006127 PASTA domain. This domain is found at the C-termini of several Penicillin-binding proteins (PBPs) and bacterial serine/threonine kinases. It is a small globular fold consisting of 3 beta-sheets and an alpha-helix. The name PASTA is derived from PBP and...; Region: PASTA; cl02768 981539006128 excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349 981539006129 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 981539006130 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 981539006131 ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271 981539006132 Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598 981539006133 uncharacterized bacterial subfamily of the Escherichia coli CorA-Salmonella typhimurium ZntB family; Region: EcCorA_ZntB-like_u2; cd12827 981539006134 Cl binding site [ion binding]; other site 981539006135 oligomer interface [polypeptide binding]; other site 981539006136 Protein of unknown function (DUF1129); Region: DUF1129; cl11555 981539006137 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 981539006138 non-specific DNA binding site [nucleotide binding]; other site 981539006139 salt bridge; other site 981539006140 sequence-specific DNA binding site [nucleotide binding]; other site 981539006141 30S ribosomal protein S18; Reviewed; Region: rpsR; PRK00391 981539006142 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 981539006143 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 981539006144 dimer interface [polypeptide binding]; other site 981539006145 ssDNA binding site [nucleotide binding]; other site 981539006146 tetramer (dimer of dimers) interface [polypeptide binding]; other site 981539006147 30S ribosomal protein S6; Reviewed; Region: rpsF; PRK00453 981539006148 BioY family; Region: BioY; pfam02632 981539006149 AAA domain; Region: AAA_26; pfam13500 981539006150 dithiobiotin synthetase; Reviewed; Region: bioD; PRK00090 981539006151 biotin synthase; Region: bioB; TIGR00433 981539006152 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 981539006153 FeS/SAM binding site; other site 981539006154 Biotin and Thiamin Synthesis associated domain; Region: BATS; pfam06968 981539006155 alkyl hydroperoxide reductase subunit F; Provisional; Region: PRK15317 981539006156 Alkyl hydroperoxide reductase F subunit (AhpF) N-terminal domain (NTD) family, N-terminal TRX-fold subdomain; AhpF is a homodimeric flavoenzyme which catalyzes the NADH-dependent reduction of the peroxiredoxin AhpC, which in turn catalyzes the reduction...; Region: AhpF_NTD_N; cd02974 981539006157 catalytic residue [active] 981539006158 TRX-GRX-like family, Alkyl hydroperoxide reductase F subunit (AhpF) N-terminal domain (NTD) subfamily, C-terminal TRX-fold subdomain; AhpF is a homodimeric flavoenzyme which catalyzes the NADH-dependent reduction of the peroxiredoxin AhpC, which then...; Region: AhpF_NTD_C; cd03026 981539006159 catalytic residues [active] 981539006160 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 981539006161 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 981539006162 peroxiredoxin; Region: AhpC; TIGR03137 981539006163 Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015 981539006164 dimer interface [polypeptide binding]; other site 981539006165 decamer (pentamer of dimers) interface [polypeptide binding]; other site 981539006166 catalytic triad [active] 981539006167 peroxidatic and resolving cysteines [active] 981539006168 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 981539006169 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 981539006170 Walker A/P-loop; other site 981539006171 ATP binding site [chemical binding]; other site 981539006172 Q-loop/lid; other site 981539006173 ABC transporter signature motif; other site 981539006174 Walker B; other site 981539006175 D-loop; other site 981539006176 H-loop/switch region; other site 981539006177 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 981539006178 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 981539006179 dimer interface [polypeptide binding]; other site 981539006180 conserved gate region; other site 981539006181 putative PBP binding loops; other site 981539006182 ABC-ATPase subunit interface; other site 981539006183 ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728 981539006184 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 981539006185 substrate binding pocket [chemical binding]; other site 981539006186 membrane-bound complex binding site; other site 981539006187 hinge residues; other site 981539006188 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 981539006189 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 981539006190 Subfamily of fatty acid CoA ligase (FACL) similar to Fum10p of Gibberella moniliformis; Region: FACL_fum10p_like; cd05926 981539006191 acyl-activating enzyme (AAE) consensus motif; other site 981539006192 acyl-activating enzyme (AAE) consensus motif; other site 981539006193 putative AMP binding site [chemical binding]; other site 981539006194 putative active site [active] 981539006195 putative CoA binding site [chemical binding]; other site 981539006196 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 981539006197 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 981539006198 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 981539006199 acyl-activating enzyme (AAE) consensus motif; other site 981539006200 acyl-activating enzyme (AAE) consensus motif; other site 981539006201 AMP binding site [chemical binding]; other site 981539006202 active site 981539006203 CoA binding site [chemical binding]; other site 981539006204 Acyltransferase family; Region: Acyl_transf_3; pfam01757 981539006205 A/G-specific DNA glycosylase [DNA replication, recombination, and repair]; Region: MutY; COG1194 981539006206 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 981539006207 minor groove reading motif; other site 981539006208 helix-hairpin-helix signature motif; other site 981539006209 substrate binding pocket [chemical binding]; other site 981539006210 active site 981539006211 DNA glycosylase (MutY in bacteria and hMYH in humans) is responsible for repairing misread A*oxoG residues to C*G by removing the inappropriately paired adenine base from the DNA backbone. It belongs to the Nudix hydrolase superfamily and is important...; Region: DNA_Glycosylase_C; cd03431 981539006212 DNA binding and oxoG recognition site [nucleotide binding] 981539006213 Glutathione-dependent formaldehyde-activating enzyme; Region: GFA; pfam04828 981539006214 oxalate/formate antiporter family transporter; Region: 2A0111; TIGR00890 981539006215 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 981539006216 putative substrate translocation pore; other site 981539006217 Predicted flavoprotein [General function prediction only]; Region: COG0431 981539006218 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 981539006219 Predicted flavoprotein [General function prediction only]; Region: COG0431 981539006220 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 981539006221 FMN-binding domain; Region: FMN_bind; pfam04205 981539006222 flavocytochrome c; Region: flavo_cyto_c; TIGR01813 981539006223 L-aspartate oxidase; Provisional; Region: PRK06175 981539006224 Protein of unknown function (DUF2992); Region: DUF2992; pfam11208 981539006225 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 981539006226 formaldehyde dehydrogenase (FDH)-like; Region: FDH_like_ADH3; cd08287 981539006227 catalytic Zn binding site [ion binding]; other site 981539006228 NAD(P) binding site [chemical binding]; other site 981539006229 structural Zn binding site [ion binding]; other site 981539006230 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 981539006231 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 981539006232 catalytic residues [active] 981539006233 Nicotinate-nucleotide pyrophosphorylase [Coenzyme metabolism]; Region: NadC; COG0157 981539006234 Quinolinate phosphoribosyl transferase (QAPRTase or QPRTase), also called nicotinate-nucleotide pyrophosphorylase, is involved in the de novo synthesis of NAD in both prokaryotes and eukaryotes. It catalyses the reaction of quinolinic acid (QA) with...; Region: QPRTase; cd01572 981539006235 dimerization interface [polypeptide binding]; other site 981539006236 active site 981539006237 L-aspartate oxidase; Provisional; Region: PRK06175 981539006238 FAD binding domain; Region: FAD_binding_2; pfam00890 981539006239 Quinolinate synthetase A protein; Region: NadA; pfam02445 981539006240 truncated conserved hypothetical protein 981539006241 truncated conserved hypothetical protein 981539006242 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 981539006243 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 981539006244 ATP-binding cassette domain of multidrug resistance protein-like transporters; Region: ABCC_MRP_Like; cd03228 981539006245 Walker A/P-loop; other site 981539006246 ATP binding site [chemical binding]; other site 981539006247 Q-loop/lid; other site 981539006248 ABC transporter signature motif; other site 981539006249 Walker B; other site 981539006250 D-loop; other site 981539006251 H-loop/switch region; other site 981539006252 Mismatch repair ATPase (MutS family) [DNA replication, recombination, and repair]; Region: COG1193 981539006253 MutS domain III; Region: MutS_III; pfam05192 981539006254 ATP-binding cassette domain of MutS2; Region: ABC_MutS2; cd03280 981539006255 Walker A/P-loop; other site 981539006256 ATP binding site [chemical binding]; other site 981539006257 Q-loop/lid; other site 981539006258 ABC transporter signature motif; other site 981539006259 Walker B; other site 981539006260 D-loop; other site 981539006261 H-loop/switch region; other site 981539006262 Smr domain; Region: Smr; pfam01713 981539006263 Uncharacterized membrane protein, required for colicin V production [General function prediction only]; Region: CvpA; COG1286 981539006264 Colicin V production protein; Region: Colicin_V; pfam02674 981539006265 Protein of unknown function (DUF1211); Region: DUF1211; pfam06736 981539006266 Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer, utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cl00514 981539006267 FMN binding site [chemical binding]; other site 981539006268 dimer interface [polypeptide binding]; other site 981539006269 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 981539006270 Old yellow enzyme (OYE)-related FMN binding domain, group 4. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a reducing agent with oxygens, quinones, and alpha,beta-unsaturated aldehydes and ketones, and can act as...; Region: OYE_like_4_FMN; cd04735 981539006271 putative active site [active] 981539006272 putative FMN binding site [chemical binding]; other site 981539006273 putative substrate binding site [chemical binding]; other site 981539006274 putative catalytic residue [active] 981539006275 Predicted transcriptional regulators [Transcription]; Region: COG1733 981539006276 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 981539006277 ribonuclease HIII; Provisional; Region: PRK00996 981539006278 Domain of unknown function (DUF3378); Region: DUF3378; pfam11858 981539006279 bacterial Ribonuclease HIII-like; Region: RNase_HII_bacteria_HIII_like; cd06590 981539006280 RNA/DNA hybrid binding site [nucleotide binding]; other site 981539006281 active site 981539006282 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 981539006283 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 981539006284 Catalytic site [active] 981539006285 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 981539006286 helicase, putative, RecD/TraA family; Region: recD_rel; TIGR01448 981539006287 H3TH domains of structure-specific 5' nucleases (or flap endonuclease-1-like) involved in DNA replication, repair, and recombination; Region: H3TH_StructSpec-5'-nucleases; cl14815 981539006288 AAA domain; Region: AAA_30; pfam13604 981539006289 Family description; Region: UvrD_C_2; pfam13538 981539006290 DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586 981539006291 active site 981539006292 DNA polymerase IV; Validated; Region: PRK02406 981539006293 DNA binding site [nucleotide binding] 981539006294 formate acetyltransferase 1; Region: pyr_form_ly_1; TIGR01255 981539006295 Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939 981539006296 Acetyltransferase (GNAT) domain; Region: Acetyltransf_5; cl17496 981539006297 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 981539006298 Coenzyme A binding pocket [chemical binding]; other site 981539006299 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 981539006300 Beta-lactamase; Region: Beta-lactamase; pfam00144 981539006301 Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cd00333 981539006302 amphipathic channel; other site 981539006303 Asn-Pro-Ala signature motifs; other site 981539006304 x-prolyl-dipeptidyl aminopeptidase; Provisional; Region: PRK05371 981539006305 X-Prolyl dipeptidyl aminopeptidase PepX, N-terminal; Region: PepX_N; pfam09168 981539006306 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 981539006307 X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain; Region: PepX_C; pfam08530 981539006308 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 981539006309 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 981539006310 dimer interface [polypeptide binding]; other site 981539006311 phosphorylation site [posttranslational modification] 981539006312 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 981539006313 ATP binding site [chemical binding]; other site 981539006314 Mg2+ binding site [ion binding]; other site 981539006315 G-X-G motif; other site 981539006316 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 981539006317 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 981539006318 active site 981539006319 phosphorylation site [posttranslational modification] 981539006320 intermolecular recognition site; other site 981539006321 dimerization interface [polypeptide binding]; other site 981539006322 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 981539006323 DNA binding site [nucleotide binding] 981539006324 phosphate transport system regulatory protein PhoU; Region: phoU_full; TIGR02135 981539006325 PhoU domain; Region: PhoU; pfam01895 981539006326 PhoU domain; Region: PhoU; pfam01895 981539006327 phosphate transporter ATP-binding protein; Provisional; Region: PRK14240 981539006328 ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260 981539006329 Walker A/P-loop; other site 981539006330 ATP binding site [chemical binding]; other site 981539006331 Q-loop/lid; other site 981539006332 ABC transporter signature motif; other site 981539006333 Walker B; other site 981539006334 D-loop; other site 981539006335 H-loop/switch region; other site 981539006336 phosphate ABC transporter, permease protein PstA; Region: 3a0107s02c; TIGR00974 981539006337 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 981539006338 dimer interface [polypeptide binding]; other site 981539006339 conserved gate region; other site 981539006340 putative PBP binding loops; other site 981539006341 ABC-ATPase subunit interface; other site 981539006342 phosphate ABC transporter, permease protein PstC; Region: phosphate_pstC; TIGR02138 981539006343 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 981539006344 dimer interface [polypeptide binding]; other site 981539006345 conserved gate region; other site 981539006346 putative PBP binding loops; other site 981539006347 ABC-ATPase subunit interface; other site 981539006348 PBP superfamily domain; Region: PBP_like_2; cl17296 981539006349 PBP superfamily domain; Region: PBP_like_2; cl17296 981539006350 hypothetical protein; Validated; Region: PRK00153 981539006351 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 981539006352 Helix-Turn-Helix DNA binding domain of the transcription regulators TipAL, Mta, and SkgA; Region: HTH_TipAL-Mta; cd01106 981539006353 DNA binding residues [nucleotide binding] 981539006354 dimer interface [polypeptide binding]; other site 981539006355 DNA polymerase III, epsilon subunit and related 3'-5' exonucleases [DNA replication, recombination, and repair]; Region: DnaQ; COG0847 981539006356 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 981539006357 active site 981539006358 catalytic site [active] 981539006359 substrate binding site [chemical binding]; other site 981539006360 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cl17220 981539006361 HI0933-like protein; Region: HI0933_like; pfam03486 981539006362 hydroxyglutarate oxidase; Provisional; Region: PRK11728 981539006363 Chromate resistance exported protein; Region: Chrome_Resist; cl01744 981539006364 30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08881 981539006365 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 981539006366 Coenzyme A binding pocket [chemical binding]; other site 981539006367 Threonine aldolase [Amino acid transport and metabolism]; Region: GLY1; COG2008 981539006368 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 981539006369 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 981539006370 catalytic residue [active] 981539006371 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 981539006372 Winged helix DNA-binding domain; Region: HTH_27; pfam13463 981539006373 Predicted membrane protein [Function unknown]; Region: COG4392 981539006374 Predicted branched-chain amino acid permease (azaleucine resistance) [Amino acid transport and metabolism]; Region: AzlC; COG1296 981539006375 Hexulose-6-phosphate isomerase (PHI). PHI is a member of the SIS (Sugar ISomerase domain) superfamily. In the ribulose monophosphate pathway of formaldehyde fixation, hexulose-6-phosphate synthase catalyzes the condensation of ribulose-5-phosphate with...; Region: SIS_PHI; cd05005 981539006376 tetramer interface [polypeptide binding]; other site 981539006377 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 981539006378 active site 981539006379 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 981539006380 active site 981539006381 phosphorylation site [posttranslational modification] 981539006382 PTS_IIB_galactitol: subunit IIB of enzyme II (EII) of the galactitol-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is a galactitol-specific permease with two cytoplasmic domains (IIA and IIB) and a...; Region: PTS_IIB_galactitol; cd05566 981539006383 active site 981539006384 P-loop; other site 981539006385 phosphorylation site [posttranslational modification] 981539006386 Phosphotransferase system, galactitol-specific IIC component [Carbohydrate transport and metabolism]; Region: GatC; COG3775 981539006387 PTS system sugar-specific permease component; Region: EIIC-GAT; cl04451 981539006388 Ribose/Galactose Isomerase; Region: LacAB_rpiB; cl00485 981539006389 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 981539006390 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 981539006391 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 981539006392 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cl00220 981539006393 UGMP family protein; Validated; Region: PRK09604 981539006394 tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725 981539006395 Carbamoyltransferase; Region: CmcH_NodU; pfam02543 981539006396 ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575 981539006397 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 981539006398 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 981539006399 Coenzyme A binding pocket [chemical binding]; other site 981539006400 tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725 981539006401 Glycoprotease family; Region: Peptidase_M22; pfam00814 981539006402 hypothetical protein; Provisional; Region: PRK13667 981539006403 mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595 981539006404 Metallo-beta-lactamase superfamily; Region: Lactamase_B; pfam00753 981539006405 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 981539006406 FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388 981539006407 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 981539006408 Surface antigen [General function prediction only]; Region: COG3942 981539006409 CHAP domain; Region: CHAP; cl17642 981539006410 glutamate synthase subunit beta; Reviewed; Region: gltD; PRK12810 981539006411 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 981539006412 Formate/glycerate dehydrogenases, D-specific 2-hydroxy acid dehydrogenases and related dehydrogenases; Region: FDH_GDH_like; cl17240 981539006413 NAD binding site [chemical binding]; other site 981539006414 glutamate synthase subunit alpha; Provisional; Region: gltB; PRK11750 981539006415 Glutamine amidotransferases class-II (Gn-AT), glutamate synthase (GltS)-type. GltS is a homodimer that synthesizes L-glutamate from 2-oxoglutarate and L-glutamine, an important step in ammonia assimilation in bacteria, cyanobacteria and plants. The...; Region: GltS; cd00713 981539006416 active site 981539006417 dimer interface [polypeptide binding]; other site 981539006418 Glutamate synthase central domain; Region: Glu_syn_central; pfam04898 981539006419 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808 981539006420 active site 981539006421 FMN binding site [chemical binding]; other site 981539006422 substrate binding site [chemical binding]; other site 981539006423 3Fe-4S cluster binding site [ion binding]; other site 981539006424 gltb_C. This domain is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS). GltS encodes a complex iron-sulfur flavoprotein that catalyzes the synthesis of L-glutamate from L-glutamine and 2-oxoglutarate. It requires the...; Region: gltB_C; cd00982 981539006425 domain interface; other site 981539006426 Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174 981539006427 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 981539006428 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 981539006429 Helix-Turn-Helix DNA binding domain of GlnR-like transcription regulators; Region: HTH_GlnR-like; cd01105 981539006430 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 981539006431 DNA binding residues [nucleotide binding] 981539006432 putative dimer interface [polypeptide binding]; other site 981539006433 Predicted membrane protein [Function unknown]; Region: COG4129 981539006434 phosphoglycerate kinase; Provisional; Region: pgk; PRK00073 981539006435 Phosphoglycerate kinase; Region: PGK; pfam00162 981539006436 substrate binding site [chemical binding]; other site 981539006437 hinge regions; other site 981539006438 ADP binding site [chemical binding]; other site 981539006439 catalytic site [active] 981539006440 Glyceraldehyde-3-phosphate dehydrogenase/erythrose-4-phosphate dehydrogenase [Carbohydrate transport and metabolism]; Region: GapA; COG0057 981539006441 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846 981539006442 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 981539006443 elongation factor G; Reviewed; Region: PRK00007 981539006444 Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886 981539006445 G1 box; other site 981539006446 putative GEF interaction site [polypeptide binding]; other site 981539006447 GTP/Mg2+ binding site [chemical binding]; other site 981539006448 Switch I region; other site 981539006449 G2 box; other site 981539006450 G3 box; other site 981539006451 Switch II region; other site 981539006452 G4 box; other site 981539006453 G5 box; other site 981539006454 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 981539006455 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 981539006456 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 981539006457 30S ribosomal protein S7; Validated; Region: PRK05302 981539006458 S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368 981539006459 S17 interaction site [polypeptide binding]; other site 981539006460 S8 interaction site; other site 981539006461 16S rRNA interaction site [nucleotide binding]; other site 981539006462 streptomycin interaction site [chemical binding]; other site 981539006463 23S rRNA interaction site [nucleotide binding]; other site 981539006464 aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site 981539006465 pur operon repressor; Provisional; Region: PRK09213 981539006466 Bacterial purine repressor, N-terminal; Region: PuR_N; pfam09182 981539006467 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 981539006468 active site 981539006469 Predicted HD-superfamily hydrolase [General function prediction only]; Region: COG3481 981539006470 YhaM_OBF_like: A subfamily of OB folds similar to that found in Bacillus subtilis YhaM and Staphylococcus aureus cmp-binding factor-1 (SaCBF1). Both these proteins are 3'-to-5'exoribonucleases. YhaM requires Mn2+ or Co2+ for activity and is...; Region: YhaM_OBF_like; cd04492 981539006471 generic binding surface II; other site 981539006472 generic binding surface I; other site 981539006473 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 981539006474 Zn2+ binding site [ion binding]; other site 981539006475 Mg2+ binding site [ion binding]; other site 981539006476 Predicted nuclease of restriction endonuclease-like fold, RmuC family [General function prediction only]; Region: COG1322 981539006477 RmuC family; Region: RmuC; pfam02646 981539006478 Thiamine pyrophosphokinase [Coenzyme metabolism]; Region: THI80; COG1564 981539006479 Thiamine pyrophosphokinase; Region: TPK; cd07995 981539006480 active site 981539006481 dimerization interface [polypeptide binding]; other site 981539006482 thiamine binding site [chemical binding]; other site 981539006483 Pentose-5-phosphate-3-epimerase [Carbohydrate transport and metabolism]; Region: Rpe; COG0036 981539006484 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 981539006485 substrate binding site [chemical binding]; other site 981539006486 hexamer interface [polypeptide binding]; other site 981539006487 metal binding site [ion binding]; metal-binding site 981539006488 GTPase RsgA; Reviewed; Region: PRK00098 981539006489 S1_YloQ_GTPase: YloQ GTase family (also known as YjeQ and CpgA), S1-like RNA-binding domain. Proteins in the YloQ GTase family bind the ribosome and have GTPase activity. The precise role of this family is unknown. The protein structure is composed of...; Region: S1_YloQ_GTPase; cd04466 981539006490 RNA binding site [nucleotide binding]; other site 981539006491 homodimer interface [polypeptide binding]; other site 981539006492 Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854 981539006493 GTPase/Zn-binding domain interface [polypeptide binding]; other site 981539006494 GTP/Mg2+ binding site [chemical binding]; other site 981539006495 G4 box; other site 981539006496 G1 box; other site 981539006497 Switch I region; other site 981539006498 G2 box; other site 981539006499 G3 box; other site 981539006500 Switch II region; other site 981539006501 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 981539006502 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 981539006503 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cl17736 981539006504 active site 981539006505 phosphorylation site [posttranslational modification] 981539006506 intermolecular recognition site; other site 981539006507 dimerization interface [polypeptide binding]; other site 981539006508 LytTr DNA-binding domain; Region: LytTR; pfam04397 981539006509 Enterocin A Immunity; Region: EntA_Immun; pfam08951 981539006510 Enterocin A Immunity; Region: EntA_Immun; pfam08951 981539006511 Protein of unknown function (DUF3884); Region: DUF3884; pfam13024 981539006512 Predicted signal transduction protein with a C-terminal ATPase domain [Signal transduction mechanisms]; Region: COG2972 981539006513 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 981539006514 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 981539006515 active site 981539006516 phosphorylation site [posttranslational modification] 981539006517 intermolecular recognition site; other site 981539006518 dimerization interface [polypeptide binding]; other site 981539006519 LytTr DNA-binding domain; Region: LytTR; pfam04397 981539006520 LytTr DNA-binding domain; Region: LytTR; pfam04397 981539006521 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 981539006522 Bacteriocin class II with double-glycine leader peptide; Region: Bacteriocin_IIc; pfam10439 981539006523 A sub-family of peptidase family C39. Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various...; Region: Peptidase_C39B; cd02418 981539006524 ABC-type bacteriocin transporter; Region: bacteriocin_ABC; TIGR01193 981539006525 putative active site [active] 981539006526 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 981539006527 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 981539006528 Walker A/P-loop; other site 981539006529 ATP binding site [chemical binding]; other site 981539006530 Q-loop/lid; other site 981539006531 ABC transporter signature motif; other site 981539006532 Walker B; other site 981539006533 D-loop; other site 981539006534 H-loop/switch region; other site 981539006535 bacteriocin secretion accessory protein; Region: bacteriocin_acc; TIGR01000 981539006536 HlyD family secretion protein; Region: HlyD_3; pfam13437 981539006537 CAAX protease self-immunity; Region: Abi; pfam02517 981539006538 CAAX protease self-immunity; Region: Abi; pfam02517 981539006539 16S ribosomal RNA methyltransferase KsgA/Dim1 family protein; Reviewed; Region: ksgA; PRK00274 981539006540 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 981539006541 S-adenosylmethionine binding site [chemical binding]; other site 981539006542 Protein of unknown function (DUF1697); Region: DUF1697; pfam08002 981539006543 ribonuclease M5; Region: 5S_RNA_mat_M5; TIGR00334 981539006544 TOPRIM_ RNase M5_like: The topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain found in Ribonuclease M5: (RNase M5) and other small primase-like proteins from bacteria and archaea. RNase M5 catalyzes the maturation of 5S rRNA in low...; Region: TOPRIM_RNase_M5_like; cd01027 981539006545 putative active site [active] 981539006546 putative metal binding site [ion binding]; other site 981539006547 Domain of unknown function (DUF4093); Region: DUF4093; pfam13331 981539006548 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 981539006549 Predicted metal-dependent hydrolases with the TIM-barrel fold [General function prediction only]; Region: COG1099 981539006550 active site 981539006551 TQXA domain; Region: TQXA_dom; TIGR03934 981539006552 Repeat unit of collagen-binding protein domain B; Region: CollagenBindB; cd00222 981539006553 domain interaction interfaces [polypeptide binding]; other site 981539006554 Repeat unit of collagen-binding protein domain B; Region: CollagenBindB; cd00222 981539006555 domain interaction interfaces [polypeptide binding]; other site 981539006556 Repeat unit of collagen-binding protein domain B; Region: CollagenBindB; cd00222 981539006557 domain interaction interfaces [polypeptide binding]; other site 981539006558 Repeat unit of collagen-binding protein domain B; Region: CollagenBindB; cd00222 981539006559 domain interaction interfaces [polypeptide binding]; other site 981539006560 L-lactate dehydrogenase; Reviewed; Region: ldh; PRK00066 981539006561 L-2-hydroxyisocapronate dehydrogenases and some bacterial L-lactate dehydrogenases; Region: HicDH_like; cd05291 981539006562 tetramer (dimer of dimers) interface [polypeptide binding]; other site 981539006563 NAD binding site [chemical binding]; other site 981539006564 dimer interface [polypeptide binding]; other site 981539006565 substrate binding site [chemical binding]; other site 981539006566 CAAX protease self-immunity; Region: Abi; pfam02517 981539006567 heavy metal-(Cd/Co/Hg/Pb/Zn)-translocating P-type ATPase; Region: ATPase-IB2_Cd; TIGR01512 981539006568 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 981539006569 Condensing enzymes; Family of enzymes that catalyze a (decarboxylating or non-decarboxylating) Claisen-like condensation reaction. Members are share strong structural similarity, and are involved in the synthesis and degradation of fatty acids, and the...; Region: cond_enzymes; cl09938 981539006570 Soluble P-type ATPase [General function prediction only]; Region: COG4087 981539006571 Sortase C (SrtC) or subfamily-3 sortases are membrane cysteine transpeptidases found in Gram-positive bacteria that anchor surface proteins to peptidoglycans of the bacterial cell wall envelope. This involves a transpeptidation reaction in which the...; Region: Sortase_C_3; cd05827 981539006572 active site 981539006573 catalytic site [active] 981539006574 LPXTG-motif cell wall anchor domain; Region: LPXTG_anchor; TIGR01167 981539006575 Listeria-Bacteroides repeat domain (List_Bact_rpt); Region: Flg_new; cl09714 981539006576 Listeria-Bacteroides repeat domain (List_Bact_rpt); Region: Flg_new; pfam09479 981539006577 Listeria-Bacteroides repeat domain (List_Bact_rpt); Region: Flg_new; pfam09479 981539006578 truncated signal peptidase I 981539006579 truncated signal peptidase I 981539006580 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 981539006581 S-adenosylmethionine binding site [chemical binding]; other site 981539006582 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 981539006583 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 981539006584 ATP-binding cassette domain of multidrug resistance protein-like transporters; Region: ABCC_MRP_Like; cd03228 981539006585 Walker A/P-loop; other site 981539006586 ATP binding site [chemical binding]; other site 981539006587 Q-loop/lid; other site 981539006588 ABC transporter signature motif; other site 981539006589 Walker B; other site 981539006590 D-loop; other site 981539006591 H-loop/switch region; other site 981539006592 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 981539006593 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 981539006594 ABC-ATPase subunit interface; other site 981539006595 dimer interface [polypeptide binding]; other site 981539006596 putative PBP binding regions; other site 981539006597 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 981539006598 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 981539006599 ABC-type metal ion transport system, periplasmic component/surface adhesin [Inorganic ion transport and metabolism]; Region: LraI; COG0803 981539006600 Metal binding protein PsaA. These proteins have been shown to function as initial receptors in ABC transport of Mn2+ and as surface adhesins in some eubacterial species. They belong to the TroA superfamily of periplasmic metal binding proteins that...; Region: PsaA; cd01137 981539006601 metal binding site [ion binding]; metal-binding site 981539006602 2-hydroxycarboxylate transporter family; Region: 2HCT; pfam03390 981539006603 malate dehydrogenase; Provisional; Region: PRK13529 981539006604 Malic enzyme, N-terminal domain; Region: malic; pfam00390 981539006605 NAD(P) binding domain of malic enzyme (ME), subgroup 1; Region: NAD_bind_1_malic_enz; cd05312 981539006606 NAD(P) binding site [chemical binding]; other site 981539006607 Transcriptional regulator [Transcription]; Region: LysR; COG0583 981539006608 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 981539006609 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 981539006610 dimerization interface [polypeptide binding]; other site 981539006611 Predicted esterase [General function prediction only]; Region: COG0400 981539006612 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 981539006613 D-alanyl-lipoteichoic acid biosynthesis protein DltD; Region: LTA_DltD; TIGR04092 981539006614 DltD N-terminal region; Region: DltD_N; pfam04915 981539006615 DltD central region; Region: DltD_M; pfam04918 981539006616 DltD C-terminal region; Region: DltD_C; pfam04914 981539006617 D-alanine--poly(phosphoribitol) ligase subunit 2; Validated; Region: PRK05087 981539006618 D-alanyl-lipoteichoic acid biosynthesis protein DltB; Region: LTA_dltB; TIGR04091 981539006619 D-alanine--poly(phosphoribitol) ligase subunit 1; Provisional; Region: PRK04813 981539006620 D-alanine:D-alanyl carrier protein ligase (DltA); Region: DltA; cd05945 981539006621 acyl-activating enzyme (AAE) consensus motif; other site 981539006622 AMP binding site [chemical binding]; other site 981539006623 D-Ala-teichoic acid biosynthesis protein; Region: DUF3687; pfam12459 981539006624 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3237 981539006625 V-type ATP synthase subunit D; Reviewed; Region: PRK00373 981539006626 V-type ATP synthase subunit B; Provisional; Region: PRK04196 981539006627 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 981539006628 V/A-type ATP synthase (non-catalytic) subunit B. These ATPases couple ATP hydrolysis to the build up of a H+ gradient, but V-type ATPases do not catalyze the reverse reaction. The Vacuolar (V-type) ATPase is found in the membranes of vacuoles, the golgi...; Region: V_A-ATPase_B; cd01135 981539006629 Walker A motif homologous position; other site 981539006630 Walker B motif; other site 981539006631 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 981539006632 V-type ATP synthase subunit A; Provisional; Region: PRK04192 981539006633 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 981539006634 V/A-type ATP synthase catalytic subunit A. These ATPases couple ATP hydrolysis to the build up of a H+ gradient, but V-type ATPases do not catalyze the reverse reaction. The Vacuolar (V-type) ATPase is found in the membranes of vacuoles, the golgi...; Region: V_A-ATPase_A; cd01134 981539006635 Walker A motif/ATP binding site; other site 981539006636 Walker B motif; other site 981539006637 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 981539006638 V-type ATP synthase subunit F; Provisional; Region: PRK01395 981539006639 Archaeal/vacuolar-type H+-ATPase subunit C [Energy production and conversion]; Region: NtpC; COG1527 981539006640 V-type ATP synthase subunit C; Provisional; Region: PRK01198; cl00660 981539006641 V-type ATP synthase subunit K; Validated; Region: PRK06558 981539006642 ATP synthase subunit C; Region: ATP-synt_C; pfam00137 981539006643 V-type ATP synthase subunit I; Validated; Region: PRK05771 981539006644 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 981539006645 Major Facilitator Superfamily; Region: MFS_1; pfam07690 981539006646 putative substrate translocation pore; other site 981539006647 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 981539006648 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 981539006649 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 981539006650 Ribosomal protein L34; Region: Ribosomal_L34; cl00370 981539006651 Protein of unknown function (DUF3021); Region: DUF3021; pfam11457 981539006652 LytTr DNA-binding domain; Region: LytTR; smart00850 981539006653 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 981539006654 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 981539006655 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 981539006656 Walker A/P-loop; other site 981539006657 ATP binding site [chemical binding]; other site 981539006658 Q-loop/lid; other site 981539006659 ABC transporter signature motif; other site 981539006660 Walker B; other site 981539006661 D-loop; other site 981539006662 H-loop/switch region; other site 981539006663 Predicted RNA-binding protein [General function prediction only]; Region: Jag; COG1847 981539006664 jag_K homology RNA-binding domain. The KH domain is found in proteins homologous to the Bacillus subtilis protein Jag, which is associated with SpoIIIJ and is necessary for the third stage of sporulation. The KH motif is a beta-alpha-alpha-beta-beta...; Region: jag_KH; cd02414 981539006665 G-X-X-G motif; other site 981539006666 R3H domain found in proteins homologous to Bacillus subtilus Jag, which is associated with SpoIIIJ. SpoIIIJ is necessary for the third stage of sporulation. The name of the R3H domain comes from the characteristic spacing of the most conserved arginine...; Region: R3H_jag; cd02644 981539006667 RxxxH motif; other site 981539006668 Preprotein translocase subunit YidC [Intracellular trafficking and secretion]; Region: YidC; COG0706 981539006669 membrane protein insertase, YidC/Oxa1 family, C-terminal domain; Region: yidC_oxa1_cterm; TIGR03592 981539006670 ribonuclease P; Reviewed; Region: rnpA; PRK00499 981539006671 argininosuccinate lyase; Provisional; Region: PRK00855 981539006672 Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359 981539006673 active sites [active] 981539006674 tetramer interface [polypeptide binding]; other site 981539006675 argininosuccinate synthase; Provisional; Region: PRK13820 981539006676 Argininosuccinate synthase. The Argininosuccinate synthase is a urea cycle enzyme that catalyzes the penultimate step in arginine biosynthesis: the ATP-dependent ligation of citrulline to aspartate to form argininosuccinate, AMP and pyrophosphate . In...; Region: Argininosuccinate_Synthase; cd01999 981539006677 ANP binding site [chemical binding]; other site 981539006678 Substrate Binding Site II [chemical binding]; other site 981539006679 Substrate Binding Site I [chemical binding]; other site 981539006680 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 981539006681 H+ Antiporter protein; Region: 2A0121; TIGR00900 981539006682 putative substrate translocation pore; other site 981539006683 Cyanate permease [Inorganic ion transport and metabolism]; Region: CynX; COG2807 981539006684 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 981539006685 putative substrate translocation pore; other site 981539006686 glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406 981539006687 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 981539006688 active site 981539006689 HIGH motif; other site 981539006690 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 981539006691 active site 981539006692 KMSKS motif; other site 981539006693 Tubby C 2; Region: Tub_2; cl02043 981539006694 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeD; cd03379 981539006695 active site clefts [active] 981539006696 zinc binding site [ion binding]; other site 981539006697 dimer interface [polypeptide binding]; other site 981539006698 DNA repair protein RadA; Provisional; Region: PRK11823 981539006699 Sms (bacterial radA) DNA repair protein. This protein is not related to archael radA any more than is to other RecA-like NTPases. Sms has a role in recombination and recombinational repair and is responsible for the stabilization or processing of...; Region: Sms; cd01121 981539006700 Walker A motif/ATP binding site; other site 981539006701 ATP binding site [chemical binding]; other site 981539006702 Walker B motif; other site 981539006703 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 981539006704 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 981539006705 trimer interface [polypeptide binding]; other site 981539006706 active site 981539006707 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1636 981539006708 NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094 981539006709 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 981539006710 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479 981539006711 Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541 981539006712 dTDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: RfbA; COG1209 981539006713 active site 981539006714 tetramer interface; other site 981539006715 Rhomboid family; Region: Rhomboid; pfam01694 981539006716 5,10-methenyltetrahydrofolate synthetase; Region: MTHFS_bact; TIGR02727 981539006717 5-formyltetrahydrofolate cyclo-ligase family; Region: 5-FTHF_cyc-lig; pfam01812 981539006718 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 981539006719 M20 Peptidase Aminoacyclase-1 YkuR-like proteins, including YkuR and Ama/HipO/HyuC proteins; Region: M20_Acy1_YkuR_like; cd05670 981539006720 metal binding site [ion binding]; metal-binding site 981539006721 putative dimer interface [polypeptide binding]; other site 981539006722 Tetrahydrodipicolinate succinyltransferase N-terminal; Region: DapH_N; pfam08503 981539006723 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-acetyltransferase; Region: DapD_Ac; TIGR03532 981539006724 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate (THDP) N-succinyltransferase (also called THP succinyltransferase): THDP N-succinyltransferase catalyzes the conversion of tetrahydrodipicolinate and succinyl-CoA to N-succinyltetrahydrodipicolinate and CoA; Region: LbH_THP_succinylT; cd03350 981539006725 trimer interface [polypeptide binding]; other site 981539006726 active site 981539006727 substrate binding site [chemical binding]; other site 981539006728 CoA binding site [chemical binding]; other site 981539006729 glucose-6-phosphate isomerase; Provisional; Region: pgi; PRK14097 981539006730 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015 981539006731 active site 981539006732 dimer interface [polypeptide binding]; other site 981539006733 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016 981539006734 dimer interface [polypeptide binding]; other site 981539006735 active site 981539006736 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 981539006737 nucleoside/Zn binding site; other site 981539006738 dimer interface [polypeptide binding]; other site 981539006739 catalytic motif [active] 981539006740 Metal-dependent hydrolases of the beta-lactamase superfamily III [General function prediction only]; Region: ElaC; COG1234 981539006741 Uncharacterized conserved protein [General function prediction only]; Region: BioY; COG1268 981539006742 queuine tRNA-ribosyltransferase; Provisional; Region: tgt; PRK00112 981539006743 Queuine/archaeosine tRNA-ribosyltransferase [Translation, ribosomal structure and biogenesis]; Region: Tgt; COG0343 981539006744 Protein of unknown function (DUF975); Region: DUF975; cl10504 981539006745 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 981539006746 metal binding site 2 [ion binding]; metal-binding site 981539006747 putative DNA binding helix; other site 981539006748 metal binding site 1 [ion binding]; metal-binding site 981539006749 dimer interface [polypeptide binding]; other site 981539006750 structural Zn2+ binding site [ion binding]; other site 981539006751 Phenolic acid decarboxylase (PAD); Region: PA_decarbox; pfam05870 981539006752 Predicted transcriptional regulators [Transcription]; Region: COG1695 981539006753 Transcriptional regulator PadR-like family; Region: PadR; cl17335 981539006754 Virulence activator alpha C-term; Region: Vir_act_alpha_C; pfam10400 981539006755 Predicted CoA-binding protein [General function prediction only]; Region: COG1832 981539006756 DNA polymerase I; Provisional; Region: PRK05755 981539006757 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 981539006758 active site 981539006759 metal binding site 1 [ion binding]; metal-binding site 981539006760 putative 5' ssDNA interaction site; other site 981539006761 metal binding site 3; metal-binding site 981539006762 metal binding site 2 [ion binding]; metal-binding site 981539006763 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 981539006764 putative DNA binding site [nucleotide binding]; other site 981539006765 putative metal binding site [ion binding]; other site 981539006766 inactive DEDDy 3'-5' exonuclease domain of Bacillus stearothermophilus DNA polymerase I and similar family-A DNA polymerases; Region: DNA_polA_I_Bacillus_like_exo; cd06140 981539006767 Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637 981539006768 active site 981539006769 DNA binding site [nucleotide binding] 981539006770 catalytic site [active] 981539006771 Membrane transport protein; Region: Mem_trans; pfam03547 981539006772 Transketolase [Carbohydrate transport and metabolism]; Region: TktA; COG0021 981539006773 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 981539006774 TPP-binding site [chemical binding]; other site 981539006775 dimer interface [polypeptide binding]; other site 981539006776 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 981539006777 PYR/PP interface [polypeptide binding]; other site 981539006778 dimer interface [polypeptide binding]; other site 981539006779 TPP binding site [chemical binding]; other site 981539006780 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 981539006781 Transaldolase-like fructose-6-phosphate aldolases (FSA) found in bacteria and archaea; Region: Transaldolase_FSA; cd00956 981539006782 active site 981539006783 intersubunit interactions; other site 981539006784 catalytic residue [active] 981539006785 putative L-ascorbate 6-phosphate lactonase; Provisional; Region: PRK11709 981539006786 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 981539006787 Transcriptional antiterminator [Transcription]; Region: BglG; COG3711 981539006788 Mga helix-turn-helix domain; Region: Mga; pfam05043 981539006789 PRD domain; Region: PRD; pfam00874 981539006790 PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568 981539006791 active site 981539006792 P-loop; other site 981539006793 phosphorylation site [posttranslational modification] 981539006794 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 981539006795 active site 981539006796 phosphorylation site [posttranslational modification] 981539006797 2-keto-3-deoxy-6-phosphogluconate aldolase [Carbohydrate transport and metabolism]; Region: Eda; COG0800 981539006798 KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452 981539006799 active site 981539006800 intersubunit interface [polypeptide binding]; other site 981539006801 catalytic residue [active] 981539006802 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 981539006803 Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408 981539006804 inhibitor site; inhibition site 981539006805 active site 981539006806 dimer interface [polypeptide binding]; other site 981539006807 catalytic residue [active] 981539006808 KpsF-like protein. KpsF is an arabinose-5-phosphate isomerase which contains SIS (Sugar ISomerase) domains. SIS domains are found in many phosphosugar isomerases and phosphosugar binding proteins. KpsF catalyzes the reversible reaction of ribulose...; Region: SIS_Kpsf; cd05014 981539006809 putative active site [active] 981539006810 PTS system ascorbate-specific transporter subunit IIC; Reviewed; Region: PRK12997 981539006811 PTS_IIB_ascorbate: subunit IIB of enzyme II (EII) of the L-ascorbate-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is an L-ascorbate-specific permease with two cytoplasmic subunits (IIA and IIB) and a...; Region: PTS_IIB_ascorbate; cd05563 981539006812 active site 981539006813 P-loop; other site 981539006814 phosphorylation site [posttranslational modification] 981539006815 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 981539006816 active site 981539006817 phosphorylation site [posttranslational modification] 981539006818 Transcriptional antiterminator [Transcription]; Region: BglG; COG3711 981539006819 PRD domain; Region: PRD; pfam00874 981539006820 PRD domain; Region: PRD; pfam00874 981539006821 PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568 981539006822 active site 981539006823 P-loop; other site 981539006824 phosphorylation site [posttranslational modification] 981539006825 L-ribulose-5-phosphate 4-epimerase; Provisional; Region: araD; PRK13145 981539006826 L-ribulose-5-phosphate 4-epimerase; Reviewed; Region: araD; PRK08193 981539006827 intersubunit interface [polypeptide binding]; other site 981539006828 active site 981539006829 Zn2+ binding site [ion binding]; other site 981539006830 putative L-xylulose 5-phosphate 3-epimerase; Reviewed; Region: PRK13210 981539006831 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cd00019 981539006832 AP (apurinic/apyrimidinic) site pocket; other site 981539006833 DNA interaction; other site 981539006834 Metal-binding active site; metal-binding site 981539006835 3-Keto-L-gulonate 6-phosphate decarboxylase (KGPDC) and D-arabino-3-hexulose-6-phosphate synthase (HPS). KGPDC catalyzes the formation of L-xylulose 5-phosphate and carbon dioxide from 3-keto-L-gulonate 6-phosphate as part of the anaerobic pathway for...; Region: KGPDC_HPS; cd04726 981539006836 active site 981539006837 dimer interface [polypeptide binding]; other site 981539006838 magnesium binding site [ion binding]; other site 981539006839 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 981539006840 active site 981539006841 phosphorylation site [posttranslational modification] 981539006842 PTS_IIB_ascorbate: subunit IIB of enzyme II (EII) of the L-ascorbate-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is an L-ascorbate-specific permease with two cytoplasmic subunits (IIA and IIB) and a...; Region: PTS_IIB_ascorbate; cd05563 981539006843 active site 981539006844 P-loop; other site 981539006845 phosphorylation site [posttranslational modification] 981539006846 PTS system ascorbate-specific transporter subunit IIC; Reviewed; Region: PRK12997 981539006847 Uncharacterized conserved protein [Function unknown]; Region: COG2128 981539006848 Uncharacterized oxidoreductases, Fe-dependent alcohol dehydrogenase family [Energy production and conversion]; Region: COG1979 981539006849 Dehydroquinate synthase-like (DHQ-like) and iron-containing alcohol dehydrogenases (Fe-ADH); Region: DHQ_Fe-ADH; cl02872 981539006850 active site 981539006851 NAD binding site [chemical binding]; other site 981539006852 metal binding site [ion binding]; metal-binding site 981539006853 ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464 981539006854 NLPA lipoprotein; Region: Lipoprotein_9; pfam03180 981539006855 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 981539006856 ABC-ATPase subunit interface; other site 981539006857 DL-methionine transporter ATP-binding subunit; Provisional; Region: metN; PRK11153 981539006858 ATP-binding cassette domain of methionine transporter; Region: ABC_MetN_methionine_transporter; cd03258 981539006859 Walker A/P-loop; other site 981539006860 ATP binding site [chemical binding]; other site 981539006861 Q-loop/lid; other site 981539006862 ABC transporter signature motif; other site 981539006863 Walker B; other site 981539006864 D-loop; other site 981539006865 H-loop/switch region; other site 981539006866 NIL domain; Region: NIL; pfam09383 981539006867 Transcriptional regulator; Region: Rrf2; cl17282 981539006868 Rrf2 family protein; Region: rrf2_super; TIGR00738 981539006869 Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788 981539006870 Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108 981539006871 GDP-binding site [chemical binding]; other site 981539006872 ACT binding site; other site 981539006873 IMP binding site; other site 981539006874 bifunctional glutamate--cysteine ligase/glutathione synthetase; Provisional; Region: PRK02471 981539006875 Glutamate-cysteine ligase; Region: Glu_cys_ligase; cl17352 981539006876 ATP-grasp domain; Region: ATP-grasp_4; cl17255 981539006877 phage transcriptional regulator, ArpU family; Region: phage_arpU; TIGR01637 981539006878 D5 N terminal like; Region: D5_N; smart00885 981539006879 phage/plasmid primase, P4 family, C-terminal domain; Region: primase_Cterm; TIGR01613 981539006880 Poxvirus D5 protein-like; Region: Pox_D5; pfam03288 981539006881 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 981539006882 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 981539006883 non-specific DNA binding site [nucleotide binding]; other site 981539006884 salt bridge; other site 981539006885 sequence-specific DNA binding site [nucleotide binding]; other site 981539006886 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 981539006887 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 981539006888 non-specific DNA binding site [nucleotide binding]; other site 981539006889 salt bridge; other site 981539006890 sequence-specific DNA binding site [nucleotide binding]; other site 981539006891 Domain of unknown function (DUF955); Region: DUF955; pfam06114 981539006892 Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582 981539006893 phiLC3 phage and phage-related integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes various bacterial (mainly gram positive) and phage integrases, including those similar to Lactococcus...; Region: INT_phiLC3_C; cd01189 981539006894 Int/Topo IB signature motif; other site 981539006895 Uncharacterized protein involved in tellurite resistance [Inorganic ion transport and metabolism]; Region: TelA; COG3853 981539006896 LytTr DNA-binding domain; Region: LytTR; smart00850 981539006897 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 981539006898 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 981539006899 Walker A/P-loop; other site 981539006900 ATP binding site [chemical binding]; other site 981539006901 Q-loop/lid; other site 981539006902 ABC transporter signature motif; other site 981539006903 Walker B; other site 981539006904 D-loop; other site 981539006905 H-loop/switch region; other site 981539006906 This family is the oxydase domain of NRPS (non-ribosomal peptide synthetase) and other proteins that modify polypeptides by cyclizing a thioester to form a ring. These include epoB, part of the epothilone biosynthesis pathway; tubD, part of the tubulysin...; Region: mcbC-like_oxidoreductase; cd02142 981539006907 NADPH bind site [chemical binding]; other site 981539006908 YcaO-like family; Region: YcaO; pfam02624 981539006909 thiazole/oxazole-forming peptide maturase, SagD family component; Region: TOMM_cyclo_SagD; TIGR03604 981539006910 Hsp33-like chaperonin; Reviewed; Region: hslO; PRK00114 981539006911 Heat shock protein 33 (Hsp33): Cytosolic protein that acts as a molecular chaperone under oxidative conditions. In normal (reducing) cytosolic conditions, four conserved Cys residues are coordinated by a Zn ion. Under oxidative stress (such as heat...; Region: Hsp33; cd00498 981539006912 dimerization interface [polypeptide binding]; other site 981539006913 domain crossover interface; other site 981539006914 redox-dependent activation switch; other site 981539006915 putative TIM-barrel protein, nifR3 family; Region: nifR3_yhdG; TIGR00737 981539006916 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 981539006917 FMN binding site [chemical binding]; other site 981539006918 active site 981539006919 catalytic residues [active] 981539006920 substrate binding site [chemical binding]; other site 981539006921 ATP-binding subunits of Clp protease and DnaK/DnaJ chaperones [Posttranslational modification, protein turnover, chaperones]; Region: clpA; COG0542 981539006922 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 981539006923 Walker A motif; other site 981539006924 ATP binding site [chemical binding]; other site 981539006925 Walker B motif; other site 981539006926 arginine finger; other site 981539006927 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 981539006928 Walker A motif; other site 981539006929 ATP binding site [chemical binding]; other site 981539006930 Walker B motif; other site 981539006931 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 981539006932 Firmicute transcriptional repressor of class III stress genes (CtsR); Region: CtsR; pfam05848 981539006933 Putative small multi-drug export protein; Region: Sm_multidrug_ex; pfam06695 981539006934 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 981539006935 non-specific DNA binding site [nucleotide binding]; other site 981539006936 salt bridge; other site 981539006937 sequence-specific DNA binding site [nucleotide binding]; other site 981539006938 H+ Antiporter protein; Region: 2A0121; TIGR00900 981539006939 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 981539006940 putative substrate translocation pore; other site 981539006941 elongation factor Ts; Provisional; Region: tsf; PRK09377 981539006942 UBA/TS-N domain; Region: UBA; pfam00627 981539006943 Elongation factor TS; Region: EF_TS; pfam00889 981539006944 Elongation factor TS; Region: EF_TS; pfam00889 981539006945 Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425 981539006946 rRNA interaction site [nucleotide binding]; other site 981539006947 S8 interaction site; other site 981539006948 putative laminin-1 binding site; other site 981539006949 Uncharacterized protein family (UPF0236); Region: UPF0236; pfam06782 981539006950 Sortase A (SrtA) or subfamily-1 sortases are cysteine transpeptidases found in gram-positive bacteria that anchor surface proteins to peptidoglycans of the bacterial cell wall envelope. They do so by catalyzing a transpeptidation reaction in which the...; Region: Sortase_A_1; cd06165 981539006951 active site 981539006952 catalytic site [active] 981539006953 Replication initiator protein A (RepA) N-terminus; Region: RepA_N; pfam06970 981539006954 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 981539006955 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 981539006956 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 981539006957 Mannosyl-glycoprotein endo-beta-N-acetylglucosaminidase; Region: Glucosaminidase; pfam01832 981539006958 CHAP domain; Region: CHAP; cl17642 981539006959 AAA-like domain; Region: AAA_10; pfam12846 981539006960 Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cl00038 981539006961 Dimer interface [polypeptide binding]; other site 981539006962 BRCT sequence motif; other site 981539006963 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 981539006964 Walker A motif; other site 981539006965 ATP binding site [chemical binding]; other site 981539006966 Type IV secretory pathway, VirD4 components [Intracellular trafficking and secretion]; Region: VirD4; COG3505 981539006967 TraM recognition site of TraD and TraG; Region: TraG-D_C; pfam12696 981539006968 GBS Bsp-like repeat; Region: GBS_Bsp-like; pfam08481 981539006969 GBS Bsp-like repeat; Region: GBS_Bsp-like; pfam08481 981539006970 GBS Bsp-like repeat; Region: GBS_Bsp-like; pfam08481 981539006971 GBS Bsp-like repeat; Region: GBS_Bsp-like; pfam08481 981539006972 GBS Bsp-like repeat; Region: GBS_Bsp-like; pfam08481 981539006973 GBS Bsp-like repeat; Region: GBS_Bsp-like; pfam08481 981539006974 GBS Bsp-like repeat; Region: GBS_Bsp-like; pfam08481 981539006975 GBS Bsp-like repeat; Region: GBS_Bsp-like; pfam08481 981539006976 Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various bacteriocins (mostly non-lantibiotic); Region: Peptidase_C39_like; cl00296 981539006977 putative active site [active] 981539006978 putative cross-wall-targeting lipoprotein signal; Region: strep_RK_lipo; TIGR03726 981539006979 LPXTG-motif cell wall anchor domain; Region: LPXTG_anchor; TIGR01167 981539006980 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 981539006981 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 981539006982 Walker A motif; other site 981539006983 ATP binding site [chemical binding]; other site 981539006984 Walker B motif; other site 981539006985 arginine finger; other site 981539006986 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 981539006987 Walker A motif; other site 981539006988 ATP binding site [chemical binding]; other site 981539006989 Walker B motif; other site 981539006990 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 981539006991 TOPRIM_TopoIA_TopoIII: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to topoisomerase III. Type IA DNA topoisomerases remove (relax) negative supercoils in the DNA by: cleaving...; Region: TOPRIM_TopoIA_TopoIII; cd03362 981539006992 active site 981539006993 putative interdomain interaction site [polypeptide binding]; other site 981539006994 Topoisomerase IA [DNA replication, recombination, and repair]; Region: TopA; COG0550 981539006995 putative metal-binding site [ion binding]; other site 981539006996 putative nucleotide binding site [chemical binding]; other site 981539006997 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 981539006998 domain I; other site 981539006999 DNA binding groove [nucleotide binding] 981539007000 phosphate binding site [ion binding]; other site 981539007001 domain II; other site 981539007002 domain III; other site 981539007003 nucleotide binding site [chemical binding]; other site 981539007004 catalytic site [active] 981539007005 domain IV; other site 981539007006 Protein of unknown function (DUF3991); Region: DUF3991; pfam13154 981539007007 Toprim-like; Region: Toprim_2; pfam13155 981539007008 Domain of unknown function (DUF955); Region: DUF955; pfam06114 981539007009 DNA/RNA non-specific endonuclease; Region: Endonuclea_NS_2; cl17626 981539007010 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 981539007011 catalytic residues [active] 981539007012 Primase C terminal 1 (PriCT-1); Region: PriCT_1; pfam08708 981539007013 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315 981539007014 DNA-methyltransferase (dcm); Region: dcm; TIGR00675 981539007015 cofactor binding site; other site 981539007016 DNA binding site [nucleotide binding] 981539007017 substrate interaction site [chemical binding]; other site 981539007018 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315 981539007019 Microcin C7 self-immunity protein determines resistance to exogenous microcin C7; Region: Peptidase_S66_mccF_like; cd07062 981539007020 putative dimer interface [polypeptide binding]; other site 981539007021 catalytic triad [active] 981539007022 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 981539007023 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 981539007024 non-specific DNA binding site [nucleotide binding]; other site 981539007025 salt bridge; other site 981539007026 sequence-specific DNA binding site [nucleotide binding]; other site 981539007027 transcriptional activator, Rgg/GadR/MutR family, C-terminal domain; Region: RGG_Cterm; TIGR01716 981539007028 Predicted metalloendopeptidase [Posttranslational modification, protein turnover, chaperones]; Region: PepO; COG3590 981539007029 Peptidase family M13 includes neprilysin, endothelin-converting enzyme I; Region: M13; cd08662 981539007030 active site 981539007031 Zn binding site [ion binding]; other site 981539007032 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 981539007033 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 981539007034 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 981539007035 alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403 981539007036 Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333 981539007037 Ca binding site [ion binding]; other site 981539007038 active site 981539007039 catalytic site [active] 981539007040 PTS system, trehalose-specific IIBC component; Region: PTS-IIBC-Tre; TIGR01992 981539007041 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 981539007042 active site turn [active] 981539007043 phosphorylation site [posttranslational modification] 981539007044 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 981539007045 Phosphotransferase system IIA components [Carbohydrate transport and metabolism]; Region: NagE; COG2190 981539007046 HPr interaction site; other site 981539007047 glycerol kinase (GK) interaction site [polypeptide binding]; other site 981539007048 active site 981539007049 phosphorylation site [posttranslational modification] 981539007050 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 981539007051 DNA-binding site [nucleotide binding]; DNA binding site 981539007052 trehalose operon repressor, B. subtilis-type; Region: trehalos_R_Bsub; TIGR02404 981539007053 UTRA domain; Region: UTRA; pfam07702 981539007054 Sortase C (SrtC) or subfamily-3 sortases are membrane cysteine transpeptidases found in Gram-positive bacteria that anchor surface proteins to peptidoglycans of the bacterial cell wall envelope. This involves a transpeptidation reaction in which the...; Region: Sortase_C_3; cd05827 981539007055 active site 981539007056 catalytic site [active] 981539007057 fimbrial isopeptide formation D2 domain; Region: RrgB_K2N_iso_D2; TIGR04226 981539007058 Cna protein B-type domain; Region: Cna_B; pfam05738 981539007059 LPXTG-motif cell wall anchor domain; Region: LPXTG_anchor; TIGR01167 981539007060 Collagen binding domain; Region: Collagen_bind; pfam05737 981539007061 Repeat unit of collagen-binding protein domain B; Region: CollagenBindB; cd00222 981539007062 domain interaction interfaces [polypeptide binding]; other site 981539007063 Repeat unit of collagen-binding protein domain B; Region: CollagenBindB; cd00222 981539007064 domain interaction interfaces [polypeptide binding]; other site 981539007065 Repeat unit of collagen-binding protein domain B; Region: CollagenBindB; cd00222 981539007066 domain interaction interfaces [polypeptide binding]; other site 981539007067 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 981539007068 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 981539007069 Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080 981539007070 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 981539007071 Walker A motif; other site 981539007072 ATP binding site [chemical binding]; other site 981539007073 Walker B motif; other site 981539007074 arginine finger; other site 981539007075 Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491 981539007076 4Fe-4S single cluster domain; Region: Fer4_12; pfam13353 981539007077 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 981539007078 FeS/SAM binding site; other site 981539007079 Predicted acetyltransferase [General function prediction only]; Region: COG3981 981539007080 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 981539007081 anaerobic ribonucleoside triphosphate reductase; Provisional; Region: PRK09263 981539007082 ATP cone domain; Region: ATP-cone; pfam03477 981539007083 Class III ribonucleotide reductase; Region: RNR_III; cd01675 981539007084 effector binding site; other site 981539007085 active site 981539007086 Zn binding site [ion binding]; other site 981539007087 glycine loop; other site 981539007088 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 981539007089 hypothetical protein; Provisional; Region: PRK13678 981539007090 Holliday junction resolvase-like protein; Reviewed; Region: PRK00109 981539007091 hypothetical protein; Provisional; Region: PRK05473 981539007092 Arsenate Reductase (ArsC) family, Spx subfamily; Spx is a unique RNA polymerase (RNAP)-binding protein present in bacilli and some mollicutes. It inhibits transcription by binding to the C-terminal domain of the alpha subunit of RNAP, disrupting complex...; Region: ArsC_Spx; cd03032 981539007093 ArsC family; Region: ArsC; pfam03960 981539007094 putative catalytic residues [active] 981539007095 thiol/disulfide switch; other site 981539007096 recombinase A; Provisional; Region: recA; PRK09354 981539007097 RecA is a bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response. RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983 981539007098 hexamer interface [polypeptide binding]; other site 981539007099 Walker A motif; other site 981539007100 ATP binding site [chemical binding]; other site 981539007101 Walker B motif; other site 981539007102 competence damage-inducible protein A; Provisional; Region: PRK00549 981539007103 Competence-damaged protein. CinA is the first gene in the competence- inducible (cin) operon and is thought to be specifically required at some stage in the process of transformation. This domain is closely related to a domain, found in a variety of...; Region: cinA; cd00885 981539007104 putative MPT binding site; other site 981539007105 Uncharacterized protein (competence- and mitomycin-induced) [General function prediction only]; Region: CinA; COG1546 981539007106 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 981539007107 Major Facilitator Superfamily; Region: MFS_1; pfam07690 981539007108 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 981539007109 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 981539007110 non-specific DNA binding site [nucleotide binding]; other site 981539007111 salt bridge; other site 981539007112 sequence-specific DNA binding site [nucleotide binding]; other site 981539007113 Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116 981539007114 RuvA N terminal domain; Region: RuvA_N; pfam01330 981539007115 DNA mismatch repair protein; Reviewed; Region: mutL; PRK00095 981539007116 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 981539007117 ATP binding site [chemical binding]; other site 981539007118 Mg2+ binding site [ion binding]; other site 981539007119 G-X-G motif; other site 981539007120 MutL_Trans: transducer domain, having a ribosomal S5 domain 2-like fold, conserved in the C-terminal domain of DNA mismatch repair (MutL/MLH1/PMS2) family. This transducer domain is homologous to the second domain of the DNA gyrase B subunit, which is...; Region: MutL_Trans; cd00782 981539007121 ATP binding site [chemical binding]; other site 981539007122 MutL C terminal dimerisation domain; Region: MutL_C; pfam08676 981539007123 DNA mismatch repair protein MutS; Provisional; Region: PRK05399 981539007124 MutS domain I; Region: MutS_I; pfam01624 981539007125 MutS domain II; Region: MutS_II; pfam05188 981539007126 MutS domain III; Region: MutS_III; pfam05192 981539007127 ATP-binding cassette domain of MutS1 homolog; Region: ABC_MutS1; cd03284 981539007128 Walker A/P-loop; other site 981539007129 ATP binding site [chemical binding]; other site 981539007130 Q-loop/lid; other site 981539007131 ABC transporter signature motif; other site 981539007132 Walker B; other site 981539007133 D-loop; other site 981539007134 H-loop/switch region; other site 981539007135 Protein of unknown function (DUF964); Region: DUF964; cl01483 981539007136 Arginine repressor, DNA binding domain; Region: Arg_repressor; pfam01316 981539007137 arginine repressor; Region: argR_whole; TIGR01529 981539007138 Arginine repressor, C-terminal domain; Region: Arg_repressor_C; pfam02863 981539007139 arginyl-tRNA synthetase; Reviewed; Region: PRK12451 981539007140 Arginyl tRNA synthetase N terminal dom; Region: Arg_tRNA_synt_N; smart01016 981539007141 catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671 981539007142 active site 981539007143 HIGH motif; other site 981539007144 KMSK motif region; other site 981539007145 Anticodon-binding domain of arginyl tRNA synthetases; Region: Anticodon_Ia_Arg; cd07956 981539007146 tRNA binding surface [nucleotide binding]; other site 981539007147 anticodon binding site; other site 981539007148 Enterocin A Immunity; Region: EntA_Immun; pfam08951 981539007149 Predicted peptidase [General function prediction only]; Region: COG4099 981539007150 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 981539007151 Uncharacterized conserved protein [Function unknown]; Region: COG1284 981539007152 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 981539007153 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 981539007154 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 981539007155 Uncharacterized conserved protein [Function unknown]; Region: COG1284 981539007156 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 981539007157 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 981539007158 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 981539007159 aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476 981539007160 EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317 981539007161 dimer interface [polypeptide binding]; other site 981539007162 anticodon binding site; other site 981539007163 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777 981539007164 homodimer interface [polypeptide binding]; other site 981539007165 motif 1; other site 981539007166 active site 981539007167 motif 2; other site 981539007168 GAD domain; Region: GAD; pfam02938 981539007169 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777 981539007170 motif 3; other site 981539007171 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 981539007172 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 981539007173 non-specific DNA binding site [nucleotide binding]; other site 981539007174 salt bridge; other site 981539007175 sequence-specific DNA binding site [nucleotide binding]; other site 981539007176 histidyl-tRNA synthetase; Reviewed; Region: hisS; PRK00037 981539007177 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 981539007178 dimer interface [polypeptide binding]; other site 981539007179 motif 1; other site 981539007180 active site 981539007181 motif 2; other site 981539007182 HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859 981539007183 anticodon binding site; other site 981539007184 50S ribosomal protein L32; Validated; Region: rpmF; PRK01110 981539007185 50S ribosomal protein L33; Validated; Region: rpmG; PRK00595 981539007186 truncated putative ATPase 981539007187 truncated putative ATPase 981539007188 Cro/C1-type HTH DNA-binding domain; Region: HTH_26; pfam13443 981539007189 glycosyltransferase family protein; Region: PLN02208 981539007190 DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674 981539007191 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 981539007192 Plasmid replication protein; Region: Rep_2; pfam01719 981539007193 phiLC3 phage and phage-related integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes various bacterial (mainly gram positive) and phage integrases, including those similar to Lactococcus...; Region: INT_phiLC3_C; cd01189 981539007194 Int/Topo IB signature motif; other site 981539007195 Antibiotic biosynthesis monooxygenase; Region: ABM; pfam03992 981539007196 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 981539007197 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 981539007198 Coenzyme A binding pocket [chemical binding]; other site 981539007199 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 981539007200 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 981539007201 putative DNA binding site [nucleotide binding]; other site 981539007202 dimerization interface [polypeptide binding]; other site 981539007203 putative Zn2+ binding site [ion binding]; other site 981539007204 Predicted transcriptional regulators [Transcription]; Region: COG1695 981539007205 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 981539007206 Predicted membrane protein [Function unknown]; Region: COG4709 981539007207 Domain of unknown function (DUF4097); Region: DUF4097; pfam13349 981539007208 Domain of unknown function (DUF4098); Region: DUF4098; pfam13345 981539007209 Predicted membrane protein [Function unknown]; Region: COG3759 981539007210 Predicted membrane protein [Function unknown]; Region: COG1511 981539007211 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061 981539007212 X-X-X-Leu-X-X-Gly heptad repeats; Region: xxxLxxG_by_4; TIGR03057 981539007213 YhgE/Pip C-terminal domain; Region: pip_yhgE_Cterm; TIGR03062 981539007214 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 981539007215 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 981539007216 30S ribosomal protein S4; Validated; Region: rpsD; PRK05327 981539007217 Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163 981539007218 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 981539007219 RNA binding surface [nucleotide binding]; other site 981539007220 Uncharacterized protein conserved in bacteria [Function unknown]; Region: Veg; COG4466 981539007221 replicative DNA helicase; Provisional; Region: PRK05748 981539007222 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 981539007223 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 981539007224 Walker A motif; other site 981539007225 ATP binding site [chemical binding]; other site 981539007226 Walker B motif; other site 981539007227 DNA binding loops [nucleotide binding] 981539007228 50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137 981539007229 Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281 981539007230 Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948 981539007231 Predicted signaling protein consisting of a modified GGDEF domain and a DHH domain [Signal transduction mechanisms]; Region: COG3887 981539007232 Class III nucleotidyl cyclases; Region: Nucleotidyl_cyc_III; cl11967 981539007233 DHH family; Region: DHH; pfam01368 981539007234 DHHA1 domain; Region: DHHA1; pfam02272 981539007235 tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA; Validated; Region: PRK05192 981539007236 tRNA:m(5)U-54 methyltransferase; Region: gid_trmFO; TIGR00137 981539007237 GidA associated domain 3; Region: GIDA_assoc_3; pfam13932 981539007238 hypothetical protein; Provisional; Region: PRK09273 981539007239 Ribose/Galactose Isomerase; Region: LacAB_rpiB; pfam02502 981539007240 Predicted tRNA(5-methylaminomethyl-2-thiouridylate) methyltransferase, contains the PP-loop ATPase domain [Translation, ribosomal structure and biogenesis]; Region: TrmU; COG0482 981539007241 tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998 981539007242 L-serine dehydratase, iron-sulfur-dependent, beta subunit; Region: sda_beta; TIGR00719 981539007243 Serine dehydratase beta chain; Region: SDH_beta; pfam03315 981539007244 C-terminal ACT domain of the L-serine dehydratase (LSD), iron-sulfur-dependent, beta subunit; Region: ACT_LSD; cd04903 981539007245 putative L-serine binding site [chemical binding]; other site 981539007246 Serine dehydratase alpha chain; Region: SDH_alpha; cl12120 981539007247 L-serine deaminase [Amino acid transport and metabolism]; Region: SdaA; COG1760 981539007248 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 981539007249 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 981539007250 motif II; other site 981539007251 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 981539007252 N-acetyl-D-glucosamine binding site [chemical binding]; other site 981539007253 catalytic residue [active] 981539007254 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 981539007255 ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619 981539007256 cobalt transporter ATP-binding subunit; Provisional; Region: cbiO; PRK13649 981539007257 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 981539007258 Walker A/P-loop; other site 981539007259 ATP binding site [chemical binding]; other site 981539007260 Q-loop/lid; other site 981539007261 ABC transporter signature motif; other site 981539007262 Walker B; other site 981539007263 D-loop; other site 981539007264 H-loop/switch region; other site 981539007265 cobalt transporter ATP-binding subunit; Provisional; Region: cbiO; PRK13650 981539007266 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 981539007267 Walker A/P-loop; other site 981539007268 ATP binding site [chemical binding]; other site 981539007269 Q-loop/lid; other site 981539007270 ABC transporter signature motif; other site 981539007271 Walker B; other site 981539007272 D-loop; other site 981539007273 H-loop/switch region; other site 981539007274 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453 981539007275 Helix-turn-helix domain; Region: HTH_25; pfam13413 981539007276 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 981539007277 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 981539007278 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 981539007279 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 981539007280 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 981539007281 S4 domain protein YaaA; Region: YaaA_near_RecF; TIGR02988 981539007282 recombination protein F; Reviewed; Region: recF; PRK00064 981539007283 ATP-binding cassette domain of RecF; Region: ABC_RecF; cd03242 981539007284 Walker A/P-loop; other site 981539007285 ATP binding site [chemical binding]; other site 981539007286 Q-loop/lid; other site 981539007287 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 981539007288 ABC transporter signature motif; other site 981539007289 Walker B; other site 981539007290 D-loop; other site 981539007291 H-loop/switch region; other site 981539007292 Putative glucose uptake permease [Carbohydrate transport and metabolism]; Region: GlcU; COG4975 981539007293 inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567 981539007294 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 981539007295 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein. IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a...; Region: CBS_pair_IMPDH; cd04601 981539007296 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 981539007297 active site 981539007298 tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282 981539007299 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 981539007300 active site 981539007301 HIGH motif; other site 981539007302 dimer interface [polypeptide binding]; other site 981539007303 KMSKS motif; other site 981539007304 Uncharacterized conserved protein [Function unknown]; Region: COG1284 981539007305 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 981539007306 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 981539007307 ABC transporter ATP-binding protein; Provisional; Region: PRK15064 981539007308 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 981539007309 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 981539007310 ABC transporter; Region: ABC_tran_2; pfam12848 981539007311 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 981539007312 Predicted membrane protein [Function unknown]; Region: COG4485 981539007313 rRNA large subunit methyltransferase; Provisional; Region: PRK00103 981539007314 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 981539007315 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 981539007316 protein binding site [polypeptide binding]; other site 981539007317 ParB/RepB/Spo0J family partition protein; Region: parB_part; TIGR00180 981539007318 ParB-like nuclease domain; Region: ParBc; pfam02195