-- dump date 20140620_082103 -- class Genbank::misc_feature -- table misc_feature_note -- id note 990317000001 chromosomal replication initiation protein; Reviewed; Region: dnaA; PRK00149 990317000002 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 990317000003 Walker A motif; other site 990317000004 ATP binding site [chemical binding]; other site 990317000005 Walker B motif; other site 990317000006 arginine finger; other site 990317000007 C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571 990317000008 DnaA box-binding interface [nucleotide binding]; other site 990317000009 DNA polymerase III subunit beta; Validated; Region: PRK05643 990317000010 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140 990317000011 putative DNA binding surface [nucleotide binding]; other site 990317000012 dimer interface [polypeptide binding]; other site 990317000013 beta-clamp/clamp loader binding surface; other site 990317000014 beta-clamp/translesion DNA polymerase binding surface; other site 990317000015 Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase [Lipid metabolism / General function prediction only]; Region: LCB5; COG1597 990317000016 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 990317000017 Bacterial protein of unknown function (DUF951); Region: DUF951; pfam06107 990317000018 GTP-binding protein YchF; Reviewed; Region: PRK09601 990317000019 YchF GTPase; Region: YchF; cd01900 990317000020 G1 box; other site 990317000021 GTP/Mg2+ binding site [chemical binding]; other site 990317000022 Switch I region; other site 990317000023 G2 box; other site 990317000024 Switch II region; other site 990317000025 G3 box; other site 990317000026 G4 box; other site 990317000027 G5 box; other site 990317000028 TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867 990317000029 Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462 990317000030 putative active site [active] 990317000031 catalytic residue [active] 990317000032 Transcription-repair coupling factor (superfamily II helicase) [DNA replication, recombination, and repair / Transcription]; Region: Mfd; COG1197 990317000033 CarD-like/TRCF domain; Region: CarD_TRCF; smart01058 990317000034 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 990317000035 ATP binding site [chemical binding]; other site 990317000036 putative Mg++ binding site [ion binding]; other site 990317000037 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 990317000038 nucleotide binding region [chemical binding]; other site 990317000039 ATP-binding site [chemical binding]; other site 990317000040 This domain is found in proteins necessary for strand-specific repair in DNA such as TRCF in Escherichia coli; Region: TRCF; smart00982 990317000041 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 990317000042 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 990317000043 sequence-specific DNA binding site [nucleotide binding]; other site 990317000044 salt bridge; other site 990317000045 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 990317000046 RNA binding surface [nucleotide binding]; other site 990317000047 Septum formation initiator [Cell division and chromosome partitioning]; Region: COG2919 990317000048 Septum formation initiator; Region: DivIC; pfam04977 990317000049 Beta-lactamase class A [Defense mechanisms]; Region: PenP; COG2367 990317000050 Beta-lactamase enzyme family; Region: Beta-lactamase2; pfam13354 990317000051 tRNA(Ile)-lysidine synthase MesJ [Cell cycle control, cell division, chromosome partitioning]; Region: MesJ; COG0037 990317000052 N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992 990317000053 Ligand Binding Site [chemical binding]; other site 990317000054 TilS substrate C-terminal domain; Region: TilS_C; smart00977 990317000055 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 990317000056 active site 990317000057 ATP-dependent Zn proteases [Posttranslational modification, protein turnover, chaperones]; Region: HflB; COG0465 990317000058 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 990317000059 Walker A motif; other site 990317000060 ATP binding site [chemical binding]; other site 990317000061 Walker B motif; other site 990317000062 arginine finger; other site 990317000063 Peptidase family M41; Region: Peptidase_M41; pfam01434 990317000064 rod shape-determining protein MreC; Provisional; Region: PRK13922 990317000065 rod shape-determining protein MreC; Region: MreC; pfam04085 990317000066 CHAP domain; Region: CHAP; pfam05257 990317000067 Surface antigen [General function prediction only]; Region: COG3942 990317000068 ribose-phosphate pyrophosphokinase; Provisional; Region: PRK02269 990317000069 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 990317000070 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 990317000071 active site 990317000072 aromatic amino acid aminotransferase; Validated; Region: PRK07309 990317000073 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 990317000074 pyridoxal 5'-phosphate binding site [chemical binding]; other site 990317000075 homodimer interface [polypeptide binding]; other site 990317000076 catalytic residue [active] 990317000077 Recombination protein O N terminal; Region: RecO_N; pfam11967 990317000078 DNA repair protein RecO; Region: reco; TIGR00613 990317000079 Recombination protein O C terminal; Region: RecO_C; pfam02565 990317000080 putative phosphate acyltransferase; Provisional; Region: PRK05331 990317000081 acyl carrier protein; Provisional; Region: PRK12449 990317000082 phosphoribosylaminoimidazole-succinocarboxamide synthase; Reviewed; Region: PRK09362 990317000083 bacterial and archaeal 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_PurC; cd01415 990317000084 ATP binding site [chemical binding]; other site 990317000085 active site 990317000086 substrate binding site [chemical binding]; other site 990317000087 phosphoribosylformylglycinamidine synthase, clade II; Region: FGAM-synthase; TIGR01857 990317000088 AIR (aminoimidazole ribonucleotide) synthase related protein. This family includes Hydrogen expression/formation protein HypE, AIR synthases, FGAM (formylglycinamidine ribonucleotide) synthase and Selenophosphate synthetase (SelD). The N-terminal domain...; Region: PurM-like; cl10019 990317000089 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203 990317000090 dimerization interface [polypeptide binding]; other site 990317000091 ATP binding site [chemical binding]; other site 990317000092 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat2; cd02204 990317000093 dimerization interface [polypeptide binding]; other site 990317000094 ATP binding site [chemical binding]; other site 990317000095 Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740 990317000096 putative active site [active] 990317000097 catalytic triad [active] 990317000098 amidophosphoribosyltransferase; Provisional; Region: PRK07272 990317000099 Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715 990317000100 active site 990317000101 tetramer interface [polypeptide binding]; other site 990317000102 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 990317000103 active site 990317000104 phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385 990317000105 PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196 990317000106 dimerization interface [polypeptide binding]; other site 990317000107 putative ATP binding site [chemical binding]; other site 990317000108 phosphoribosylglycinamide formyltransferase; Reviewed; Region: purN; PRK05647 990317000109 Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645 990317000110 active site 990317000111 substrate binding site [chemical binding]; other site 990317000112 cosubstrate binding site; other site 990317000113 catalytic site [active] 990317000114 GNAT acetyltransferase; Region: GNAT_acetyltran; pfam12746 990317000115 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881 990317000116 Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal ATIC formylase domain that formylates...; Region: IMPCH; cd01421 990317000117 purine monophosphate binding site [chemical binding]; other site 990317000118 dimer interface [polypeptide binding]; other site 990317000119 putative catalytic residues [active] 990317000120 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; smart00798 990317000121 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; cl03362 990317000122 phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885 990317000123 Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844 990317000124 Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Region: GARS_A; pfam01071 990317000125 Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843 990317000126 Protein of unknown function (DUF523); Region: DUF523; pfam04463 990317000127 Phosphoribosylcarboxyaminoimidazole (NCAIR) mutase [Nucleotide transport and metabolism]; Region: PurE; COG0041 990317000128 phosphoribosylaminoimidazole carboxylase ATPase subunit; Reviewed; Region: PRK06019 990317000129 ATP-grasp domain; Region: ATP-grasp; pfam02222 990317000130 poly-beta-1,6 N-acetyl-D-glucosamine synthase; Region: PgaC_IcaA; TIGR03937 990317000131 adenylosuccinate lyase; Provisional; Region: PRK07492 990317000132 Adenylsuccinate lyase (ASL)_subgroup 1; Region: Adenylsuccinate_lyase_1; cd01360 990317000133 tetramer interface [polypeptide binding]; other site 990317000134 active site 990317000135 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 990317000136 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 990317000137 non-specific DNA binding site [nucleotide binding]; other site 990317000138 salt bridge; other site 990317000139 sequence-specific DNA binding site [nucleotide binding]; other site 990317000140 Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394 990317000141 Low molecular weight phosphatase family; Region: LMWPc; cd00115 990317000142 active site 990317000143 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4642 990317000144 MORN repeat; Region: MORN; cl14787 990317000145 Acyltransferase family; Region: Acyl_transf_3; pfam01757 990317000146 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053 990317000147 active site 990317000148 catalytic triad [active] 990317000149 oxyanion hole [active] 990317000150 Threonine synthase catalyzes the final step of threonine biosynthesis. The conversion of O-phosphohomoserine into threonine and inorganic phosphate is pyridoxal 5'-phosphate dependent. The Thr-synth_1 CD includes members from higher plants; Region: Thr-synth_2; cd01560 990317000151 Threonine synthase [Amino acid transport and metabolism]; Region: ThrC; COG0498 990317000152 pyridoxal 5'-phosphate binding site [chemical binding]; other site 990317000153 catalytic residue [active] 990317000154 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 990317000155 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Thermotoga marina NorM; Region: MATE_NorM_like; cd13137 990317000156 MMPL family; Region: MMPL; pfam03176 990317000157 MMPL family; Region: MMPL; pfam03176 990317000158 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 990317000159 Histidine kinase; Region: HisKA_3; pfam07730 990317000160 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 990317000161 ATP binding site [chemical binding]; other site 990317000162 Mg2+ binding site [ion binding]; other site 990317000163 G-X-G motif; other site 990317000164 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 990317000165 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 990317000166 active site 990317000167 phosphorylation site [posttranslational modification] 990317000168 intermolecular recognition site; other site 990317000169 dimerization interface [polypeptide binding]; other site 990317000170 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 990317000171 DNA binding residues [nucleotide binding] 990317000172 dimerization interface [polypeptide binding]; other site 990317000173 Transcriptional regulator [Transcription]; Region: LysR; COG0583 990317000174 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 990317000175 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 990317000176 dimerization interface [polypeptide binding]; other site 990317000177 30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596 990317000178 50S ribosomal protein L3; Validated; Region: rplC; PRK00001 990317000179 50S ribosomal protein L4; Provisional; Region: rplD; PRK05319 990317000180 50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738 990317000181 50S ribosomal protein L2; Validated; Region: rplB; PRK09374 990317000182 Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181 990317000183 Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947 990317000184 30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357 990317000185 Ribosomal protein L22/L17e. L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit. It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336 990317000186 putative translocon binding site; other site 990317000187 protein-rRNA interface [nucleotide binding]; other site 990317000188 30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310 990317000189 K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3 is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel. The KH...; Region: 30S_S3_KH; cd02412 990317000190 G-X-X-G motif; other site 990317000191 Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189 990317000192 Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433 990317000193 23S rRNA interface [nucleotide binding]; other site 990317000194 5S rRNA interface [nucleotide binding]; other site 990317000195 putative antibiotic binding site [chemical binding]; other site 990317000196 L25 interface [polypeptide binding]; other site 990317000197 L27 interface [polypeptide binding]; other site 990317000198 Ribosomal L29 protein/HIP. L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals. L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427 990317000199 23S rRNA interface [nucleotide binding]; other site 990317000200 putative translocon interaction site; other site 990317000201 signal recognition particle (SRP54) interaction site; other site 990317000202 L23 interface [polypeptide binding]; other site 990317000203 trigger factor interaction site; other site 990317000204 30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610 990317000205 50S ribosomal protein L14; Validated; Region: rplN; PRK05483 990317000206 50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004 990317000207 KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089 990317000208 RNA binding site [nucleotide binding]; other site 990317000209 50S ribosomal protein L5; Validated; Region: rplE; PRK00010 990317000210 Ribosomal protein L5; Region: Ribosomal_L5; pfam00281 990317000211 ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673 990317000212 30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08061 990317000213 30S ribosomal protein S8; Validated; Region: rpsH; PRK00136 990317000214 50S ribosomal protein L6; Validated; Region: rplF; PRK05498 990317000215 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 990317000216 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 990317000217 Ribosomal L18/L5e: L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432 990317000218 5S rRNA interface [nucleotide binding]; other site 990317000219 L27 interface [polypeptide binding]; other site 990317000220 23S rRNA interface [nucleotide binding]; other site 990317000221 L5 interface [polypeptide binding]; other site 990317000222 30S ribosomal protein S5; Validated; Region: rpsE; PRK00550 990317000223 Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333 990317000224 Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719 990317000225 Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins that...; Region: Ribosomal_L30; cd01658 990317000226 23S rRNA binding site [nucleotide binding]; other site 990317000227 50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592 990317000228 preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204 990317000229 SecY translocase; Region: SecY; pfam00344 990317000230 adenylate kinase; Reviewed; Region: adk; PRK00279 990317000231 Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428 990317000232 AMP-binding site [chemical binding]; other site 990317000233 ATP-AMP (Ap5A)-binding site [chemical binding]; other site 990317000234 S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451 990317000235 rRNA binding site [nucleotide binding]; other site 990317000236 predicted 30S ribosome binding site; other site 990317000237 Ribosomal protein L36; Region: Ribosomal_L36; pfam00444 990317000238 Ribosomal protein S13 [Translation, ribosomal structure and biogenesis]; Region: RpsM; COG0099 990317000239 30S ribosomal protein S13; Region: bact_S13; TIGR03631 990317000240 30S ribosomal protein S11; Validated; Region: PRK05309 990317000241 DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182 990317000242 N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928 990317000243 alphaNTD homodimer interface [polypeptide binding]; other site 990317000244 alphaNTD - beta interaction site [polypeptide binding]; other site 990317000245 alphaNTD - beta' interaction site [polypeptide binding]; other site 990317000246 Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118 990317000247 50S ribosomal protein L17; Validated; Region: rplQ; PRK05591 990317000248 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 990317000249 salt bridge; other site 990317000250 non-specific DNA binding site [nucleotide binding]; other site 990317000251 sequence-specific DNA binding site [nucleotide binding]; other site 990317000252 Phage derived protein Gp49-like (DUF891); Region: Gp49; pfam05973 990317000253 integrase; Provisional; Region: int; PHA02601 990317000254 phiLC3 phage and phage-related integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes various bacterial (mainly gram positive) and phage integrases, including those similar to Lactococcus...; Region: INT_phiLC3_C; cd01189 990317000255 Int/Topo IB signature motif; other site 990317000256 Domain of unknown function (DUF3173); Region: DUF3173; pfam11372 990317000257 Plasmid replication protein; Region: Rep_2; pfam01719 990317000258 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 990317000259 RNA helicase; Region: RNA_helicase; pfam00910 990317000260 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 990317000261 non-specific DNA binding site [nucleotide binding]; other site 990317000262 salt bridge; other site 990317000263 sequence-specific DNA binding site [nucleotide binding]; other site 990317000264 type 2 lantibiotic biosynthesis protein LanM; Region: lanti_2_LanM; TIGR03897 990317000265 LanC-like proteins. LanC is the cyclase enzyme of the lanthionine synthetase. Lanthionine is a lantibiotic, a unique class of peptide antibiotics. They are ribosomally synthesized as a precursor peptide and then post-translationally modified to contain...; Region: LanC_like; cl04955 990317000266 active site 990317000267 zinc binding site [ion binding]; other site 990317000268 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 990317000269 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 990317000270 Walker A/P-loop; other site 990317000271 ATP binding site [chemical binding]; other site 990317000272 Q-loop/lid; other site 990317000273 ABC transporter signature motif; other site 990317000274 Walker B; other site 990317000275 D-loop; other site 990317000276 H-loop/switch region; other site 990317000277 LanC-like proteins. LanC is the cyclase enzyme of the lanthionine synthetase. Lanthionine is a lantibiotic, a unique class of peptide antibiotics. They are ribosomally synthesized as a precursor peptide and then post-translationally modified to contain...; Region: LanC_like; cl04955 990317000278 active site 990317000279 zinc binding site [ion binding]; other site 990317000280 ABC-type bacteriocin/lantibiotic exporters, contain an N-terminal double-glycine peptidase domain [Defense mechanisms]; Region: SunT; COG2274 990317000281 Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various bacteriocins (mostly non-lantibiotic); Region: Peptidase_C39_like; cl00296 990317000282 putative active site [active] 990317000283 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 990317000284 Walker A/P-loop; other site 990317000285 ATP binding site [chemical binding]; other site 990317000286 Q-loop/lid; other site 990317000287 ABC transporter signature motif; other site 990317000288 Walker B; other site 990317000289 D-loop; other site 990317000290 H-loop/switch region; other site 990317000291 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 990317000292 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 990317000293 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: ipk; PRK00128 990317000294 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 990317000295 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 990317000296 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 990317000297 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 990317000298 putative Zn2+ binding site [ion binding]; other site 990317000299 putative DNA binding site [nucleotide binding]; other site 990317000300 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 990317000301 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 990317000302 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 990317000303 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 990317000304 ABC-ATPase subunit interface; other site 990317000305 dimer interface [polypeptide binding]; other site 990317000306 putative PBP binding regions; other site 990317000307 tyrosyl-tRNA synthetase; Validated; Region: PRK05912 990317000308 catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805 990317000309 active site 990317000310 HIGH motif; other site 990317000311 dimer interface [polypeptide binding]; other site 990317000312 KMSKS motif; other site 990317000313 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 990317000314 RNA binding surface [nucleotide binding]; other site 990317000315 Membrane carboxypeptidase (penicillin-binding protein) [Cell envelope biogenesis, outer membrane]; Region: MrcB; COG0744 990317000316 Transglycosylase; Region: Transgly; pfam00912 990317000317 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 990317000318 DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405 990317000319 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585 990317000320 RNA polymerase Rpb2, domain 2; Region: RNA_pol_Rpb2_2; pfam04561 990317000321 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 990317000322 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 990317000323 RPB1 interaction site [polypeptide binding]; other site 990317000324 RPB12 interaction site [polypeptide binding]; other site 990317000325 RPB10 interaction site [polypeptide binding]; other site 990317000326 RPB11 interaction site [polypeptide binding]; other site 990317000327 RPB3 interaction site [polypeptide binding]; other site 990317000328 RPB12 interaction site [polypeptide binding]; other site 990317000329 DNA-directed RNA polymerase subunit beta'; Provisional; Region: PRK00566 990317000330 RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997 990317000331 RNA polymerase I subunit A N-terminus; Region: RPOLA_N; smart00663 990317000332 RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983 990317000333 RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000 990317000334 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 990317000335 Rpb1 (beta') - Rpb6 (omega) interaction site [polypeptide binding]; other site 990317000336 G-loop; other site 990317000337 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 990317000338 DNA binding site [nucleotide binding] 990317000339 Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site 990317000340 Protein of unknown function (DUF1033); Region: DUF1033; pfam06279 990317000341 Type II/IV secretion system protein; Region: T2SE; pfam00437 990317000342 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 990317000343 Walker A motif; other site 990317000344 ATP binding site [chemical binding]; other site 990317000345 Walker B motif; other site 990317000346 Competence protein ComGC [Intracellular trafficking and secretion]; Region: ComGC; COG4537 990317000347 Type II secretory pathway, pseudopilin PulG [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulG; COG2165 990317000348 Type II secretory pathway pseudopilin; Region: PulG; pfam11773 990317000349 Competence protein ComGF [Intracellular trafficking and secretion]; Region: ComGF; COG4940 990317000350 Methyltransferase domain; Region: Methyltransf_31; pfam13847 990317000351 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 990317000352 S-adenosylmethionine binding site [chemical binding]; other site 990317000353 acetate kinase A/propionate kinase 2; Reviewed; Region: PRK00180 990317000354 propionate/acetate kinase; Provisional; Region: PRK12379 990317000355 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 990317000356 non-specific DNA binding site [nucleotide binding]; other site 990317000357 salt bridge; other site 990317000358 sequence-specific DNA binding site [nucleotide binding]; other site 990317000359 CAAX protease self-immunity; Region: Abi; pfam02517 990317000360 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232 990317000361 pyrroline-5-carboxylate reductase; Reviewed; Region: PRK11880 990317000362 Cellulase M and related proteins [Carbohydrate transport and metabolism]; Region: FrvX; COG1363 990317000363 glutamyl aminopeptidase; Region: glu_aminopep; TIGR03107 990317000364 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 990317000365 catalytic residues [active] 990317000366 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 990317000367 putative tRNA-binding site [nucleotide binding]; other site 990317000368 Methyltransferase domain; Region: Methyltransf_31; pfam13847 990317000369 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 990317000370 S-adenosylmethionine binding site [chemical binding]; other site 990317000371 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 990317000372 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 990317000373 dimer interface [polypeptide binding]; other site 990317000374 ssDNA binding site [nucleotide binding]; other site 990317000375 tetramer (dimer of dimers) interface [polypeptide binding]; other site 990317000376 putative selenium metabolism protein, YedE family; Region: seleno_YedE; TIGR04112 990317000377 Sulphur transport; Region: Sulf_transp; pfam04143 990317000378 SirA, YedF, and YeeD. Two-layered alpha/beta sandwich domain. SirA (also known as UvrY, and YhhP) belongs to a family of bacterial two-component response regulators that controls secondary metabolism and virulence. The other member of this...; Region: SirA_YedF_YeeD; cd00291 990317000379 CPxP motif; other site 990317000380 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 990317000381 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 990317000382 active site 990317000383 motif I; other site 990317000384 motif II; other site 990317000385 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 990317000386 Sporulation related domain; Region: SPOR; cl10051 990317000387 Cadherin-like beta sandwich domain; Region: Cadherin-like; pfam12733 990317000388 Glycosyl hydrolases family 32; Region: Glyco_32; smart00640 990317000389 Glycosyl hydrolase family 32, beta-fructosidases; Region: GH32_B_Fructosidase; cd08996 990317000390 substrate binding [chemical binding]; other site 990317000391 active site 990317000392 Glycosyl hydrolases family 32 C terminal; Region: Glyco_hydro_32C; pfam08244 990317000393 Laminin G domain; Region: Laminin_G_2; pfam02210 990317000394 RNA polymerase sigma factor; Provisional; Region: PRK12541 990317000395 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: RbsB; COG1879 990317000396 Periplasmic sugar-binding domain of active transport systems that are members of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_sugar_binding_like; cd01536 990317000397 ligand binding site [chemical binding]; other site 990317000398 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 990317000399 Histidine kinase; Region: HisKA_3; pfam07730 990317000400 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 990317000401 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 990317000402 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 990317000403 active site 990317000404 phosphorylation site [posttranslational modification] 990317000405 intermolecular recognition site; other site 990317000406 dimerization interface [polypeptide binding]; other site 990317000407 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 990317000408 DNA binding residues [nucleotide binding] 990317000409 dimerization interface [polypeptide binding]; other site 990317000410 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 990317000411 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 990317000412 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cl00025 990317000413 active pocket/dimerization site; other site 990317000414 active site 990317000415 phosphorylation site [posttranslational modification] 990317000416 PTS_IIB, PTS system, Mannose/sorbose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_man; cl00021 990317000417 active site 990317000418 phosphorylation site [posttranslational modification] 990317000419 PTS system sorbose-specific iic component; Region: EII-Sor; pfam03609 990317000420 PTS system mannose/fructose/sorbose family IID component; Region: EIID-AGA; pfam03613 990317000421 Domain of unknown function (DUF4191); Region: DUF4191; pfam13829 990317000422 Type I periplasmic ligand-binding domain of uncharacterized ABC-type transport systems that are predicted to be involved in the uptake of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_uncharacterized_transporter; cd06325 990317000423 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 990317000424 zinc binding site [ion binding]; other site 990317000425 putative ligand binding site [chemical binding]; other site 990317000426 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 990317000427 Transmembrane subunit (TM) of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which are involved in the uptake of branched-chain amino acids (AAs), as well as TMs of transporters involved in the uptake of...; Region: TM_PBP1_branched-chain-AA_like; cd06574 990317000428 TM-ABC transporter signature motif; other site 990317000429 ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: PhnK; COG1101 990317000430 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 990317000431 Walker A/P-loop; other site 990317000432 ATP binding site [chemical binding]; other site 990317000433 Q-loop/lid; other site 990317000434 ABC transporter signature motif; other site 990317000435 Walker B; other site 990317000436 D-loop; other site 990317000437 H-loop/switch region; other site 990317000438 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 990317000439 oligomerisation interface [polypeptide binding]; other site 990317000440 mobile loop; other site 990317000441 roof hairpin; other site 990317000442 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 990317000443 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 990317000444 ring oligomerisation interface [polypeptide binding]; other site 990317000445 ATP/Mg binding site [chemical binding]; other site 990317000446 stacking interactions; other site 990317000447 hinge regions; other site 990317000448 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 990317000449 non-specific DNA binding site [nucleotide binding]; other site 990317000450 salt bridge; other site 990317000451 sequence-specific DNA binding site [nucleotide binding]; other site 990317000452 transcriptional activator, Rgg/GadR/MutR family, C-terminal domain; Region: RGG_Cterm; TIGR01716 990317000453 Predicted membrane protein [Function unknown]; Region: COG4640 990317000454 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 990317000455 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 990317000456 active site 990317000457 Transglycosylase; Region: Transgly; pfam00912 990317000458 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 990317000459 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 990317000460 50S ribosomal protein L33; Validated; Region: rpmG; PRK00504 990317000461 Preprotein translocase subunit SecE [Intracellular trafficking and secretion]; Region: SecE; COG0690 990317000462 transcription antitermination protein NusG; Validated; Region: nusG; PRK05609 990317000463 Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891 990317000464 putative homodimer interface [polypeptide binding]; other site 990317000465 NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091 990317000466 heterodimer interface [polypeptide binding]; other site 990317000467 homodimer interface [polypeptide binding]; other site 990317000468 Ion transport protein; Region: Ion_trans; pfam00520 990317000469 Ion channel; Region: Ion_trans_2; pfam07885 990317000470 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: COG4667 990317000471 Hypothetical patatin similar to yjju protein of Escherichia coli; Region: Pat_hypo_Ecoli_yjju_like; cd07208 990317000472 active site 990317000473 nucleophile elbow; other site 990317000474 leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390 990317000475 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 990317000476 HIGH motif; other site 990317000477 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 990317000478 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 990317000479 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 990317000480 active site 990317000481 KMSKS motif; other site 990317000482 Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958 990317000483 tRNA binding surface [nucleotide binding]; other site 990317000484 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 990317000485 galactose mutarotase_like; Region: galactose_mutarotase_like; cd09019 990317000486 active site 990317000487 catalytic residues [active] 990317000488 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 990317000489 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 990317000490 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 990317000491 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 990317000492 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 990317000493 recombination factor protein RarA; Reviewed; Region: PRK13342 990317000494 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 990317000495 Walker A motif; other site 990317000496 ATP binding site [chemical binding]; other site 990317000497 Walker B motif; other site 990317000498 arginine finger; other site 990317000499 MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002 990317000500 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 990317000501 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 990317000502 Coenzyme A binding pocket [chemical binding]; other site 990317000503 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 990317000504 Protein of unknown function (DUF3013); Region: DUF3013; pfam11217 990317000505 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 990317000506 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 990317000507 Coenzyme A binding pocket [chemical binding]; other site 990317000508 GNAT acetyltransferase 2; Region: GNAT_acetyltr_2; pfam13718 990317000509 Ribosomal protein L11 methyltransferase (PrmA); Region: PrmA; pfam06325 990317000510 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 990317000511 S-adenosylmethionine binding site [chemical binding]; other site 990317000512 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1385 990317000513 RNA methyltransferase, RsmE family; Region: TIGR00046 990317000514 Transcriptional regulators [Transcription]; Region: PurR; COG1609 990317000515 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 990317000516 DNA binding site [nucleotide binding] 990317000517 domain linker motif; other site 990317000518 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 990317000519 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 990317000520 PTS system, IIBC component; Region: PTS-II-BC-unk1; TIGR02003 990317000521 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 990317000522 active site turn [active] 990317000523 phosphorylation site [posttranslational modification] 990317000524 Phosphotransferase system IIA components [Carbohydrate transport and metabolism]; Region: NagE; COG2190 990317000525 HPr interaction site; other site 990317000526 glycerol kinase (GK) interaction site [polypeptide binding]; other site 990317000527 active site 990317000528 phosphorylation site [posttranslational modification] 990317000529 Streptococcus agalactiae RgfB, part of a putative two component signal transduction system, and related proteins; Region: RgfB-like; cd09079 990317000530 putative catalytic site [active] 990317000531 putative metal binding site [ion binding]; other site 990317000532 putative phosphate binding site [ion binding]; other site 990317000533 Cellulase M and related proteins [Carbohydrate transport and metabolism]; Region: FrvX; COG1363 990317000534 M42 Peptidase, Endoglucanase-like subfamily; Region: M42_glucanase_like; cd05657 990317000535 putative oligomer interface [polypeptide binding]; other site 990317000536 putative active site [active] 990317000537 metal binding site [ion binding]; metal-binding site 990317000538 flavoprotein NrdI; Provisional; Region: PRK02551 990317000539 cellobiose phosphotransferase system IIB component; Reviewed; Region: celB; PRK09590 990317000540 active site 990317000541 P-loop; other site 990317000542 phosphorylation site [posttranslational modification] 990317000543 PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_lac; cd00215 990317000544 methionine cluster; other site 990317000545 active site 990317000546 phosphorylation site [posttranslational modification] 990317000547 metal binding site [ion binding]; metal-binding site 990317000548 Beta-glucosidase/6-phospho-beta-glucosidase/beta- galactosidase [Carbohydrate transport and metabolism]; Region: BglB; COG2723 990317000549 beta-galactosidase; Region: BGL; TIGR03356 990317000550 Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455 990317000551 cellobiose phosphotransferase system IIC component; Reviewed; Region: celD; PRK09592 990317000552 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 990317000553 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 990317000554 DNA-binding site [nucleotide binding]; DNA binding site 990317000555 The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; Region: UTRA; smart00866 990317000556 Phosphomannose isomerase [Carbohydrate transport and metabolism]; Region: ManA; COG1482 990317000557 mannose-6-phosphate isomerase, class I; Region: manA; TIGR00218 990317000558 Aspartate alpha-decarboxylase or L-aspartate 1-decarboxylase, a pyruvoyl group-dependent decarboxylase in beta-alanine production; Region: Asp_decarbox; cd06919 990317000559 tetramerization interface [polypeptide binding]; other site 990317000560 active site 990317000561 Pantoate-beta-alanine ligase; Region: PanC; cd00560 990317000562 pantoate--beta-alanine ligase; Region: panC; TIGR00018 990317000563 active site 990317000564 ATP-binding site [chemical binding]; other site 990317000565 pantoate-binding site; other site 990317000566 HXXH motif; other site 990317000567 Ketopantoate hydroxymethyltransferase (KPHMT) is the first enzyme in the pantothenate biosynthesis pathway. Ketopantoate hydroxymethyltransferase (KPHMT) catalyzes the first committed step in the biosynthesis of pantothenate (vitamin B5), which is a...; Region: KPHMT-like; cd06557 990317000568 oligomerization interface [polypeptide binding]; other site 990317000569 active site 990317000570 metal binding site [ion binding]; metal-binding site 990317000571 Ricin-type beta-trefoil lectin domain; Region: Ricin_B_lectin; pfam00652 990317000572 Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific...; Region: RICIN; cd00161 990317000573 putative sugar binding sites [chemical binding]; other site 990317000574 Q-X-W motif; other site 990317000575 Cellulase (glycosyl hydrolase family 5); Region: Cellulase; pfam00150 990317000576 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 990317000577 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 990317000578 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 990317000579 dimer interface [polypeptide binding]; other site 990317000580 conserved gate region; other site 990317000581 putative PBP binding loops; other site 990317000582 ABC-ATPase subunit interface; other site 990317000583 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 990317000584 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 990317000585 dimer interface [polypeptide binding]; other site 990317000586 conserved gate region; other site 990317000587 ABC-ATPase subunit interface; other site 990317000588 Alpha-galactosidase [Carbohydrate transport and metabolism]; Region: GalA; COG3345 990317000589 Melibiase; Region: Melibiase; pfam02065 990317000590 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 990317000591 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 990317000592 DNA-binding site [nucleotide binding]; DNA binding site 990317000593 The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; Region: UTRA; smart00866 990317000594 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 990317000595 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 990317000596 nucleotide binding site [chemical binding]; other site 990317000597 SGNH_hydrolase subfamily. SGNH hydrolases are a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site...; Region: SGNH_hydrolase_like_2; cd01834 990317000598 active site 990317000599 catalytic triad [active] 990317000600 oxyanion hole [active] 990317000601 Acetyl xylan esterase (AXE1); Region: AXE1; pfam05448 990317000602 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 990317000603 HD domain; Region: HD_4; pfam13328 990317000604 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 990317000605 synthetase active site [active] 990317000606 NTP binding site [chemical binding]; other site 990317000607 metal binding site [ion binding]; metal-binding site 990317000608 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 990317000609 ACT domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876 990317000610 D-Tyrosyl-tRNAtyr deacylases; a class of tRNA-dependent hydrolases which are capable of hydrolyzing the ester bond of D-Tyrosyl-tRNA reducing the level of cellular D-Tyrosine while recycling the peptidyl-tRNA; found in bacteria and in eukaryotes but not...; Region: Dtyr_deacylase; cd00563 990317000611 putative active site [active] 990317000612 dimerization interface [polypeptide binding]; other site 990317000613 putative tRNAtyr binding site [nucleotide binding]; other site 990317000614 Regulator of polyketide synthase expression [Signal transduction mechanisms / Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2508 990317000615 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 990317000616 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 990317000617 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 990317000618 Walker A/P-loop; other site 990317000619 ATP binding site [chemical binding]; other site 990317000620 Q-loop/lid; other site 990317000621 ABC transporter signature motif; other site 990317000622 Walker B; other site 990317000623 D-loop; other site 990317000624 H-loop/switch region; other site 990317000625 TOBE domain; Region: TOBE_2; pfam08402 990317000626 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 990317000627 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 990317000628 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 990317000629 Ribose/Galactose Isomerase; Region: LacAB_rpiB; cl00485 990317000630 galactose-6-phosphate isomerase subunit LacB; Reviewed; Region: PRK08622 990317000631 1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164 990317000632 tagatose-6-phosphate kinase; Region: lacC; TIGR01231 990317000633 putative substrate binding site [chemical binding]; other site 990317000634 putative ATP binding site [chemical binding]; other site 990317000635 tagatose 1,6-diphosphate aldolase; Reviewed; Region: PRK12399 990317000636 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 990317000637 active site 990317000638 phosphorylation site [posttranslational modification] 990317000639 Phosphotransferase system, galactitol-specific IIB component [Carbohydrate transport and metabolism]; Region: SgaB; COG3414 990317000640 active site 990317000641 P-loop; other site 990317000642 phosphorylation site [posttranslational modification] 990317000643 Phosphotransferase system, galactitol-specific IIC component [Carbohydrate transport and metabolism]; Region: GatC; COG3775 990317000644 PTS system sugar-specific permease component; Region: EIIC-GAT; pfam03611 990317000645 Aldose 1-epimerase, similar to Lactococcus lactis lacX; Region: Aldose_epim_lacX; cd09024 990317000646 active site 990317000647 catalytic residues [active] 990317000648 transcriptional antiterminator BglG; Provisional; Region: PRK09772 990317000649 CAT RNA binding domain; Region: CAT_RBD; smart01061 990317000650 PRD domain; Region: PRD; pfam00874 990317000651 PRD domain; Region: PRD; pfam00874 990317000652 6-phospho-beta-galactosidase; Provisional; Region: PRK13511 990317000653 beta-galactosidase; Region: BGL; TIGR03356 990317000654 PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_lac; cd00215 990317000655 methionine cluster; other site 990317000656 active site 990317000657 phosphorylation site [posttranslational modification] 990317000658 metal binding site [ion binding]; metal-binding site 990317000659 Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; cl17295 990317000660 Phosphotransferase system, EIIC; Region: PTS_EIIC; pfam02378 990317000661 PTS_IIB: subunit IIB of enzyme II (EII) is the central energy-coupling domain of the phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In the multienzyme PTS complex, EII is a carbohydrate-specific permease consisting of two cytoplasmic...; Region: PTS_IIB; cl10014 990317000662 active site 990317000663 P-loop; other site 990317000664 phosphorylation site [posttranslational modification] 990317000665 Glycosyl hydrolase family 53; Region: Glyco_hydro_53; cl06672 990317000666 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 990317000667 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 990317000668 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 990317000669 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 990317000670 Alpha-galactosidase [Carbohydrate transport and metabolism]; Region: GalA; COG3345 990317000671 Melibiase; Region: Melibiase; pfam02065 990317000672 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 990317000673 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 990317000674 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 990317000675 dimer interface [polypeptide binding]; other site 990317000676 conserved gate region; other site 990317000677 putative PBP binding loops; other site 990317000678 ABC-ATPase subunit interface; other site 990317000679 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 990317000680 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 990317000681 dimer interface [polypeptide binding]; other site 990317000682 conserved gate region; other site 990317000683 putative PBP binding loops; other site 990317000684 ABC-ATPase subunit interface; other site 990317000685 sucrose phosphorylase; Region: sucrose_gtfA; TIGR03852 990317000686 Alpha amylase catalytic domain found in sucrose phosphorylase (also called sucrose glucosyltransferase, disaccharide glucosyltransferase, and sucrose-phosphate alpha-D glucosyltransferase); Region: AmyAc_Sucrose_phosphorylase; cd11355 990317000687 active site 990317000688 homodimer interface [polypeptide binding]; other site 990317000689 catalytic site [active] 990317000690 alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403 990317000691 Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333 990317000692 Ca binding site [ion binding]; other site 990317000693 active site 990317000694 catalytic site [active] 990317000695 Domain of unknown function (DUF3459); Region: DUF3459; pfam11941 990317000696 DNA-binding transcriptional repressor EbgR; Provisional; Region: PRK10339 990317000697 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 990317000698 DNA binding site [nucleotide binding] 990317000699 Ligand-binding domain of DNA transcription repressor GalR which is one of two regulatory proteins involved in galactose transport and metabolism; Region: PBP1_GalR; cd01544 990317000700 putative dimerization interface [polypeptide binding]; other site 990317000701 putative ligand binding site [chemical binding]; other site 990317000702 galactokinase; Provisional; Region: PRK05322 990317000703 Galactokinase galactose-binding signature; Region: GalKase_gal_bdg; pfam10509 990317000704 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 990317000705 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 990317000706 galactose-1-phosphate uridylyltransferase; Provisional; Region: PRK05270 990317000707 Galactose-1-phosphate uridyl transferase, N-terminal domain; Region: GalP_UDP_transf; pfam01087 990317000708 Galactose-1-phosphate uridyl transferase, C-terminal domain; Region: GalP_UDP_tr_C; pfam02744 990317000709 UDP-glucose 4-epimerase [Cell envelope biogenesis, outer membrane]; Region: GalE; COG1087 990317000710 UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247 990317000711 NAD binding site [chemical binding]; other site 990317000712 homodimer interface [polypeptide binding]; other site 990317000713 active site 990317000714 substrate binding site [chemical binding]; other site 990317000715 mycothiol synthase; Region: mycothiol_MshD; TIGR03448 990317000716 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 990317000717 Coenzyme A binding pocket [chemical binding]; other site 990317000718 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 990317000719 Coenzyme A binding pocket [chemical binding]; other site 990317000720 preprotein translocase subunit YajC; Validated; Region: yajC; PRK06531 990317000721 Undecaprenyl pyrophosphate synthase [Lipid metabolism]; Region: UppS; COG0020 990317000722 Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cd00475 990317000723 catalytic residue [active] 990317000724 putative FPP diphosphate binding site; other site 990317000725 putative FPP binding hydrophobic cleft; other site 990317000726 dimer interface [polypeptide binding]; other site 990317000727 putative IPP diphosphate binding site; other site 990317000728 CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575 990317000729 Cytidylyltransferase family; Region: CTP_transf_1; pfam01148 990317000730 RIP metalloprotease RseP; Region: TIGR00054 990317000731 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 990317000732 active site 990317000733 Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020 990317000734 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 990317000735 protein binding site [polypeptide binding]; other site 990317000736 Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020 990317000737 Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020 990317000738 putative substrate binding region [chemical binding]; other site 990317000739 putative substrate binding region [chemical binding]; other site 990317000740 prolyl-tRNA synthetase; Provisional; Region: PRK09194 990317000741 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 990317000742 motif 1; other site 990317000743 dimer interface [polypeptide binding]; other site 990317000744 active site 990317000745 motif 2; other site 990317000746 INS is an amino acid-editing domain inserted (INS) into the bacterial class II prolyl-tRNA synthetase (ProRS) however, this CD is not exclusively bacterial. It is also found at the N-terminus of the eukaryotic/archaea-like ProRS's of yeasts and...; Region: ProRS-INS; cd04334 990317000747 putative deacylase active site [active] 990317000748 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 990317000749 active site 990317000750 motif 3; other site 990317000751 ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding; Region: ProRS_anticodon_short; cd00861 990317000752 anticodon binding site; other site 990317000753 DNA polymerase III PolC; Validated; Region: polC; PRK00448 990317000754 DNA polymerase III polC-type N-terminus; Region: DNA_pol3_alph_N; pfam11490 990317000755 polC_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold nucleic acid binding domain of Bacillus subtilis type C replicative DNA polymerase III alpha subunit (polC). Replication in B. subtilis and Staphylococcus aureus requires two...; Region: polC_OBF; cd04484 990317000756 generic binding surface II; other site 990317000757 generic binding surface I; other site 990317000758 Polymerase and Histidinol Phosphatase domain; Region: PHP; cl17102 990317000759 active site 990317000760 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 990317000761 active site 990317000762 catalytic site [active] 990317000763 substrate binding site [chemical binding]; other site 990317000764 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III at PolC gene; Region: PHP_PolIIIA_POLC; cd07435 990317000765 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 990317000766 MarR family; Region: MarR; pfam01047 990317000767 MarR family; Region: MarR_2; cl17246 990317000768 Predicted flavoprotein [General function prediction only]; Region: COG0431 990317000769 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 990317000770 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 990317000771 active site 990317000772 catalytic residues [active] 990317000773 metal binding site [ion binding]; metal-binding site 990317000774 DNA-binding transcriptional activator YeiL; Provisional; Region: PRK10402 990317000775 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 990317000776 ligand binding site [chemical binding]; other site 990317000777 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cl17320 990317000778 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 990317000779 Major Facilitator Superfamily; Region: MFS_1; pfam07690 990317000780 putative substrate translocation pore; other site 990317000781 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 990317000782 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 990317000783 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 990317000784 putative active site [active] 990317000785 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_3; cd07241 990317000786 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 990317000787 putative metal binding site [ion binding]; other site 990317000788 Cof subfamily of IIB subfamily of haloacid dehalogenase superfamily; Region: Cof-subfamily; TIGR00099 990317000789 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 990317000790 active site 990317000791 motif I; other site 990317000792 motif II; other site 990317000793 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 990317000794 Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353 990317000795 16S/18S rRNA binding site [nucleotide binding]; other site 990317000796 S13e-L30e interaction site [polypeptide binding]; other site 990317000797 25S rRNA binding site [nucleotide binding]; other site 990317000798 bifunctional acetaldehyde-CoA/alcohol dehydrogenase; Provisional; Region: PRK13805 990317000799 Coenzyme A acylating aldehyde dehydrogenase (ACDH), ALDH family 20-like; Region: ALDH_F20_ACDH; cd07122 990317000800 putative catalytic cysteine [active] 990317000801 C-terminal alcohol dehydrogenase domain of the acetaldehyde dehydrogenase-alcohol dehydrogenase bifunctional two-domain protein (AAD); Region: AAD_C; cd08178 990317000802 putative active site [active] 990317000803 metal binding site [ion binding]; metal-binding site 990317000804 Predicted membrane protein [Function unknown]; Region: COG2261 990317000805 polynucleotide phosphorylase/polyadenylase; Provisional; Region: PRK11824 990317000806 Polyribonucleotide nucleotidyltransferase, repeat 1; Region: RNase_PH_PNPase_1; cd11363 990317000807 RNase E interface [polypeptide binding]; other site 990317000808 trimer interface [polypeptide binding]; other site 990317000809 Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364 990317000810 RNase E interface [polypeptide binding]; other site 990317000811 trimer interface [polypeptide binding]; other site 990317000812 active site 990317000813 Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393 990317000814 S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472 990317000815 RNA binding site [nucleotide binding]; other site 990317000816 Serine acetyltransferase [Amino acid transport and metabolism]; Region: CysE; COG1045 990317000817 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354 990317000818 trimer interface [polypeptide binding]; other site 990317000819 active site 990317000820 substrate binding site [chemical binding]; other site 990317000821 CoA binding site [chemical binding]; other site 990317000822 cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260 990317000823 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 990317000824 active site 990317000825 HIGH motif; other site 990317000826 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 990317000827 KMSKS motif; other site 990317000828 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 990317000829 tRNA binding surface [nucleotide binding]; other site 990317000830 anticodon binding site; other site 990317000831 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 990317000832 active site 990317000833 metal binding site [ion binding]; metal-binding site 990317000834 dimerization interface [polypeptide binding]; other site 990317000835 rRNA methylase, putative, group 3; Region: rRNA_methyl_3; TIGR00186 990317000836 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032 990317000837 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 990317000838 YacP-like NYN domain; Region: NYN_YacP; cl01491 990317000839 EDD domain protein, DegV family; Region: DegV; TIGR00762 990317000840 Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645 990317000841 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 990317000842 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 990317000843 non-specific DNA binding site [nucleotide binding]; other site 990317000844 salt bridge; other site 990317000845 sequence-specific DNA binding site [nucleotide binding]; other site 990317000846 Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558 990317000847 2-dehydropantoate 2-reductase; Reviewed; Region: PRK06522 990317000848 Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546 990317000849 Ribosomal protein L13. Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392 990317000850 23S rRNA interface [nucleotide binding]; other site 990317000851 L3 interface [polypeptide binding]; other site 990317000852 30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132 990317000853 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 990317000854 active site 990317000855 DNA binding site [nucleotide binding] 990317000856 Int/Topo IB signature motif; other site 990317000857 DNA binding domain, excisionase family; Region: excise; TIGR01764 990317000858 Plasmid replication protein; Region: Rep_2; pfam01719 990317000859 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 990317000860 Helix-turn-helix domain; Region: HTH_38; pfam13936 990317000861 HTH-like domain; Region: HTH_21; pfam13276 990317000862 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 990317000863 Integrase core domain; Region: rve; pfam00665 990317000864 Integrase core domain; Region: rve_2; pfam13333 990317000865 Plasmid replication protein; Region: Rep_2; pfam01719 990317000866 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 990317000867 non-specific DNA binding site [nucleotide binding]; other site 990317000868 salt bridge; other site 990317000869 sequence-specific DNA binding site [nucleotide binding]; other site 990317000870 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl17200 990317000871 non-specific DNA binding site [nucleotide binding]; other site 990317000872 salt bridge; other site 990317000873 sequence-specific DNA binding site [nucleotide binding]; other site 990317000874 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 990317000875 ACT domain proteins similar to the yet uncharacterized Streptococcus pneumoniae ACT domain protein; Region: ACT_1ZPV; cd04872 990317000876 Uncharacterized proteins with similarity to Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL_like_DUF711; cd08025 990317000877 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 990317000878 catalytic core [active] 990317000879 D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: VanY; COG1876 990317000880 D-alanyl-D-alanine carboxypeptidase; Region: VanY; pfam02557 990317000881 Mannosyl-glycoprotein endo-beta-N-acetylglucosaminidase; Region: Glucosaminidase; cl17361 990317000882 heat-inducible transcription repressor; Provisional; Region: hrcA; PRK00082 990317000883 GrpE; Region: GrpE; pfam01025 990317000884 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446 990317000885 dimer interface [polypeptide binding]; other site 990317000886 hsp70 (ATPase domain) interactions [polypeptide binding]; other site 990317000887 molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290 990317000888 Nucleotide-binding domain of human HSPA9 and similar proteins; Region: HSPA9-Ssq1-like_NBD; cd10234 990317000889 nucleotide binding site [chemical binding]; other site 990317000890 NEF interaction site [polypeptide binding]; other site 990317000891 SBD interface [polypeptide binding]; other site 990317000892 potential frameshift: common BLAST hit: gi|288904463|ref|YP_003429684.1| ThiJ/PfpI family protein 990317000893 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 990317000894 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 990317000895 conserved cys residue [active] 990317000896 chaperone protein DnaJ; Provisional; Region: PRK14276 990317000897 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 990317000898 HSP70 interaction site [polypeptide binding]; other site 990317000899 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cl03262 990317000900 substrate binding site [polypeptide binding]; other site 990317000901 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 990317000902 Zn binding sites [ion binding]; other site 990317000903 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 990317000904 dimer interface [polypeptide binding]; other site 990317000905 tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021 990317000906 Eukaryotic and bacterial pseudouridine synthases similar to E. coli TruA; Region: PseudoU_synth_EcTruA; cd02570 990317000907 dimerization interface 3.5A [polypeptide binding]; other site 990317000908 active site 990317000909 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 990317000910 dimer interface [polypeptide binding]; other site 990317000911 substrate binding site [chemical binding]; other site 990317000912 ATP binding site [chemical binding]; other site 990317000913 ECF-type riboflavin transporter, S component; Region: ECF-ribofla_trS; pfam07155 990317000914 Protein of unknown function (DUF3816); Region: DUF3816; pfam12822 990317000915 hypothetical protein; Provisional; Region: PRK13690 990317000916 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 990317000917 Mechanosensitive ion channel; Region: MS_channel; pfam00924 990317000918 trigger factor; Provisional; Region: tig; PRK01490 990317000919 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 990317000920 Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698 990317000921 DNA-directed RNA polymerase delta subunit; Region: RNA_pol_delta; pfam05066 990317000922 CTP synthetase; Validated; Region: pyrG; PRK05380 990317000923 CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113 990317000924 Catalytic site [active] 990317000925 active site 990317000926 UTP binding site [chemical binding]; other site 990317000927 Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746 990317000928 active site 990317000929 putative oxyanion hole; other site 990317000930 catalytic triad [active] 990317000931 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 990317000932 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 990317000933 fructose-bisphosphate aldolase; Provisional; Region: PRK09197 990317000934 Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947 990317000935 intersubunit interface [polypeptide binding]; other site 990317000936 active site 990317000937 zinc binding site [ion binding]; other site 990317000938 Na+ binding site [ion binding]; other site 990317000939 50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359 990317000940 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1302 990317000941 DAK2 domain fusion protein YloV; Region: YloV; TIGR03599 990317000942 DAK2 domain; Region: Dak2; pfam02734 990317000943 dihydroxy-acid dehydratase; Provisional; Region: PRK00911 990317000944 6-phosphogluconate dehydratase; Region: edd; TIGR01196 990317000945 acetolactate synthase catalytic subunit; Reviewed; Region: PRK07282 990317000946 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 990317000947 PYR/PP interface [polypeptide binding]; other site 990317000948 dimer interface [polypeptide binding]; other site 990317000949 TPP binding site [chemical binding]; other site 990317000950 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 990317000951 Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015 990317000952 TPP-binding site [chemical binding]; other site 990317000953 dimer interface [polypeptide binding]; other site 990317000954 acetolactate synthase 3 regulatory subunit; Reviewed; Region: ilvH; PRK11895 990317000955 N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878 990317000956 putative valine binding site [chemical binding]; other site 990317000957 dimer interface [polypeptide binding]; other site 990317000958 Small subunit of acetolactate synthase; Region: ALS_ss_C; pfam10369 990317000959 ketol-acid reductoisomerase; Provisional; Region: PRK05479 990317000960 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvN; pfam07991 990317000961 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450 990317000962 threonine dehydratase; Validated; Region: PRK08639 990317000963 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 990317000964 tetramer interface [polypeptide binding]; other site 990317000965 pyridoxal 5'-phosphate binding site [chemical binding]; other site 990317000966 catalytic residue [active] 990317000967 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 990317000968 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 990317000969 A subgroup of the band 7 domain of flotillin (reggie) like proteins. This subgroup contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin. Many of these band 7 domain-containing proteins are lipid raft-associated. Individual...; Region: Band_7_4; cd03407 990317000970 VanZ like family; Region: VanZ; pfam04892 990317000971 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 990317000972 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 990317000973 Walker A/P-loop; other site 990317000974 ATP binding site [chemical binding]; other site 990317000975 Q-loop/lid; other site 990317000976 ABC transporter signature motif; other site 990317000977 Walker B; other site 990317000978 D-loop; other site 990317000979 H-loop/switch region; other site 990317000980 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 990317000981 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 990317000982 substrate binding pocket [chemical binding]; other site 990317000983 membrane-bound complex binding site; other site 990317000984 hinge residues; other site 990317000985 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 990317000986 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 990317000987 dimer interface [polypeptide binding]; other site 990317000988 conserved gate region; other site 990317000989 putative PBP binding loops; other site 990317000990 ABC-ATPase subunit interface; other site 990317000991 Predicted membrane protein (DUF2207); Region: DUF2207; pfam09972 990317000992 undecaprenyl pyrophosphate phosphatase; Reviewed; Region: PRK00281 990317000993 adaptor protein; Provisional; Region: PRK02315 990317000994 UDP-N-acetylmuramyl pentapeptide phosphotransferase/UDP-N- acetylglucosamine-1-phosphate transferase [Cell envelope biogenesis, outer membrane]; Region: Rfe; COG0472 990317000995 This subfamily contains Escherichia coli WecA, Bacillus subtilis TagO and related proteins. WecA is an UDP-N-acetylglucosamine (GlcNAc):undecaprenyl-phosphate (Und-P) GlcNAc-1-phosphate transferase that catalyzes the formation of a phosphodiester bond...; Region: GT_WecA_like; cd06853 990317000996 Mg++ binding site [ion binding]; other site 990317000997 putative catalytic motif [active] 990317000998 substrate binding site [chemical binding]; other site 990317000999 Cysteine desulfurase activator ATPase [Posttranslational modification, protein turnover, chaperones]; Region: sufC; COG0396 990317001000 ABC-type transport system involved in Fe-S cluster assembly, ATPase component; Region: ABC_FeS_Assembly; cd03217 990317001001 Walker A/P-loop; other site 990317001002 ATP binding site [chemical binding]; other site 990317001003 Q-loop/lid; other site 990317001004 ABC transporter signature motif; other site 990317001005 Walker B; other site 990317001006 D-loop; other site 990317001007 H-loop/switch region; other site 990317001008 Cysteine desulfurase activator SufB [Posttranslational modification, protein turnover, chaperones]; Region: SufB; COG0719 990317001009 cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814; cl03223 990317001010 FeS assembly protein SufD; Region: sufD; TIGR01981 990317001011 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 990317001012 Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453 990317001013 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 990317001014 catalytic residue [active] 990317001015 NifU homolog involved in Fe-S cluster formation [Energy production and conversion]; Region: IscU; COG0822 990317001016 Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664 990317001017 trimerization site [polypeptide binding]; other site 990317001018 active site 990317001019 cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814; cl03223 990317001020 FeS assembly protein SufB; Region: sufB; TIGR01980 990317001021 D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: DacC; COG1686 990317001022 Beta-lactamase; Region: Beta-lactamase; cl17358 990317001023 Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; smart00936 990317001024 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 990317001025 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 990317001026 peptide binding site [polypeptide binding]; other site 990317001027 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 990317001028 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 990317001029 dimer interface [polypeptide binding]; other site 990317001030 conserved gate region; other site 990317001031 putative PBP binding loops; other site 990317001032 ABC-ATPase subunit interface; other site 990317001033 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 990317001034 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 990317001035 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 990317001036 dimer interface [polypeptide binding]; other site 990317001037 conserved gate region; other site 990317001038 putative PBP binding loops; other site 990317001039 ABC-ATPase subunit interface; other site 990317001040 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 990317001041 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 990317001042 Walker A/P-loop; other site 990317001043 ATP binding site [chemical binding]; other site 990317001044 Q-loop/lid; other site 990317001045 ABC transporter signature motif; other site 990317001046 Walker B; other site 990317001047 D-loop; other site 990317001048 H-loop/switch region; other site 990317001049 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 990317001050 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 990317001051 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 990317001052 Walker A/P-loop; other site 990317001053 ATP binding site [chemical binding]; other site 990317001054 Q-loop/lid; other site 990317001055 ABC transporter signature motif; other site 990317001056 Walker B; other site 990317001057 D-loop; other site 990317001058 H-loop/switch region; other site 990317001059 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352 990317001060 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 990317001061 Endoglucanase [Carbohydrate transport and metabolism]; Region: BglC; COG2730 990317001062 Cellulase (glycosyl hydrolase family 5); Region: Cellulase; pfam00150 990317001063 aspartate kinase; Reviewed; Region: PRK09034 990317001064 AAK_AKiii-YclM-BS: Amino Acid Kinase Superfamily (AAK), AKiii-YclM-BS; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the lysine plus threonine-sensitive aspartokinase isoenzyme AKIII, a monofunctional class enzyme found in...; Region: AAK_AKiii-YclM-BS; cd04245 990317001065 putative catalytic residues [active] 990317001066 putative nucleotide binding site [chemical binding]; other site 990317001067 putative aspartate binding site [chemical binding]; other site 990317001068 ACT domains located C-terminal to the catalytic domain of the lysine plus threonine-sensitive aspartokinase isoenzyme AKIII; Region: ACT_AKiii-YclM-BS_1; cd04911 990317001069 allosteric regulatory residue; other site 990317001070 ACT domains located C-terminal to the catalytic domain of the lysine plus threonine-sensitive aspartokinase isoenzyme AKIII; Region: ACT_AKiii-YclM-BS_2; cd04916 990317001071 Predicted phosphatase/phosphohexomutase [General function prediction only]; Region: COG0637 990317001072 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 990317001073 motif II; other site 990317001074 enoyl-CoA hydratase; Provisional; Region: PRK07260 990317001075 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 990317001076 substrate binding site [chemical binding]; other site 990317001077 oxyanion hole (OAH) forming residues; other site 990317001078 trimer interface [polypeptide binding]; other site 990317001079 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 990317001080 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 990317001081 putative Zn2+ binding site [ion binding]; other site 990317001082 putative DNA binding site [nucleotide binding]; other site 990317001083 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352 990317001084 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 990317001085 dimer interface [polypeptide binding]; other site 990317001086 active site 990317001087 CoA binding pocket [chemical binding]; other site 990317001088 acyl carrier protein; Provisional; Region: acpP; PRK00982 990317001089 putative enoyl-[acyl-carrier-protein] reductase II; Region: enACPred_II; TIGR03151 990317001090 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 990317001091 FMN binding site [chemical binding]; other site 990317001092 substrate binding site [chemical binding]; other site 990317001093 putative catalytic residue [active] 990317001094 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 990317001095 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 990317001096 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 990317001097 beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333 990317001098 NAD(P) binding site [chemical binding]; other site 990317001099 homotetramer interface [polypeptide binding]; other site 990317001100 homodimer interface [polypeptide binding]; other site 990317001101 active site 990317001102 3-oxoacyl-(acyl carrier protein) synthase II; Reviewed; Region: PRK07314 990317001103 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 990317001104 dimer interface [polypeptide binding]; other site 990317001105 active site 990317001106 potential frameshift: common BLAST hit: gi|288904558|ref|YP_003429779.1| acetyl-CoA carboxylase (biotin carboxyl carrier subunit) 990317001107 acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated; Region: PRK06302 990317001108 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 990317001109 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 990317001110 carboxyltransferase (CT) interaction site; other site 990317001111 biotinylation site [posttranslational modification]; other site 990317001112 FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288 990317001113 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591 990317001114 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 990317001115 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 990317001116 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 990317001117 acetyl-CoA carboxylase subunit beta; Validated; Region: PRK05654 990317001118 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 990317001119 acetyl-CoA carboxylase subunit alpha; Provisional; Region: PRK12319 990317001120 seryl-tRNA synthetase; Provisional; Region: PRK05431 990317001121 Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403 990317001122 Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770 990317001123 dimer interface [polypeptide binding]; other site 990317001124 active site 990317001125 motif 1; other site 990317001126 motif 2; other site 990317001127 motif 3; other site 990317001128 Domain of unknown function (DUF956); Region: DUF956; pfam06115 990317001129 Phosphotransferase system, mannose/fructose/N-acetylgalactosamine-specific component IID [Carbohydrate transport and metabolism]; Region: ManZ; COG3716 990317001130 PTS system mannose-specific transporter subunit IIC; Provisional; Region: PRK15065 990317001131 PTS system mannose-specific transporter subunits IIAB; Provisional; Region: PRK15088 990317001132 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006 990317001133 active pocket/dimerization site; other site 990317001134 active site 990317001135 phosphorylation site [posttranslational modification] 990317001136 PTS_IIB, PTS system, Mannose/sorbose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_man; cd00001 990317001137 active site 990317001138 phosphorylation site [posttranslational modification] 990317001139 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 990317001140 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 990317001141 active site 990317001142 motif I; other site 990317001143 motif II; other site 990317001144 Protein of unknown function (DUF1361); Region: DUF1361; pfam07099 990317001145 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 990317001146 Predicted ATPase or kinase [General function prediction only]; Region: COG0802 990317001147 putative acetyltransferase YhhY; Provisional; Region: PRK10140 990317001148 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 990317001149 Coenzyme A binding pocket [chemical binding]; other site 990317001150 Transcriptional regulator [Transcription]; Region: LytR; COG1316 990317001151 HINT (histidine triad nucleotide-binding protein) subgroup: Members of this CD belong to the superfamily of histidine triad hydrolases that act on alpha-phosphate of ribonucleotides. This subgroup includes members from all three forms of cellular life; Region: HINT_subgroup; cd01277 990317001152 HIT family signature motif; other site 990317001153 catalytic residue [active] 990317001154 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 990317001155 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 990317001156 Walker A/P-loop; other site 990317001157 ATP binding site [chemical binding]; other site 990317001158 Q-loop/lid; other site 990317001159 ABC transporter signature motif; other site 990317001160 Walker B; other site 990317001161 D-loop; other site 990317001162 H-loop/switch region; other site 990317001163 Bacterial ABC transporter protein EcsB; Region: EcsB; pfam05975 990317001164 Thiamine kinase and related kinases [Coenzyme transport and metabolism]; Region: ycfN; COG0510 990317001165 Phosphotransferase enzyme family; Region: APH; pfam01636 990317001166 substrate binding site [chemical binding]; other site 990317001167 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 990317001168 S-adenosylmethionine binding site [chemical binding]; other site 990317001169 PAS fold; Region: PAS_4; pfam08448 990317001170 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 990317001171 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 990317001172 metal binding site [ion binding]; metal-binding site 990317001173 active site 990317001174 I-site; other site 990317001175 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 990317001176 active site 990317001177 DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179 990317001178 DXD motif; other site 990317001179 Putative Catalytic site; other site 990317001180 Predicted membrane protein [Function unknown]; Region: COG2246 990317001181 GtrA-like protein; Region: GtrA; pfam04138 990317001182 Glycosyltransferases, probably involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: COG1215 990317001183 CESA_CelA_like are involved in the elongation of the glucan chain of cellulose; Region: CESA_CelA_like; cd06421 990317001184 DXD motif; other site 990317001185 PilZ domain; Region: PilZ; pfam07238 990317001186 ribosome maturation protein RimP; Reviewed; Region: PRK00092 990317001187 Bacillus subtilis YxlS-like, C-terminal domain; Region: YlxS_C; cd01734 990317001188 putative oligomer interface [polypeptide binding]; other site 990317001189 putative RNA binding site [nucleotide binding]; other site 990317001190 transcription elongation factor NusA; Provisional; Region: nusA; PRK12327 990317001191 NusA N-terminal domain; Region: NusA_N; pfam08529 990317001192 S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455 990317001193 RNA binding site [nucleotide binding]; other site 990317001194 homodimer interface [polypeptide binding]; other site 990317001195 NusA-like KH domain; Region: KH_5; pfam13184 990317001196 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 990317001197 G-X-X-G motif; other site 990317001198 Ylxr homologs; group of conserved hypothetical bacterial proteins of unknown function; structure revealed putative RNA binding cleft; proteins are encoded by an operon that includes other proteins involved in transcription and/or translation; Region: YlxR; cd00279 990317001199 putative RNA binding cleft [nucleotide binding]; other site 990317001200 hypothetical protein; Provisional; Region: PRK07283 990317001201 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 990317001202 translation initiation factor IF-2; Region: IF-2; TIGR00487 990317001203 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 990317001204 Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887 990317001205 G1 box; other site 990317001206 putative GEF interaction site [polypeptide binding]; other site 990317001207 GTP/Mg2+ binding site [chemical binding]; other site 990317001208 Switch I region; other site 990317001209 G2 box; other site 990317001210 G3 box; other site 990317001211 Switch II region; other site 990317001212 G4 box; other site 990317001213 G5 box; other site 990317001214 This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702 990317001215 Translation-initiation factor 2; Region: IF-2; pfam11987 990317001216 mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692 990317001217 ribosome-binding factor A; Validated; Region: rbfA; PRK00521 990317001218 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 990317001219 Helix-turn-helix domain; Region: HTH_38; pfam13936 990317001220 HTH-like domain; Region: HTH_21; pfam13276 990317001221 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 990317001222 Integrase core domain; Region: rve; pfam00665 990317001223 Integrase core domain; Region: rve_2; pfam13333 990317001224 Predicted Rossmann fold nucleotide-binding protein [General function prediction only]; Region: COG1611 990317001225 Bacterial protein of unknown function (DUF925); Region: DUF925; pfam06042 990317001226 copper transport repressor, CopY/TcrY family; Region: CopY_TcrY; TIGR02698 990317001227 Penicillinase repressor; Region: Pencillinase_R; pfam03965 990317001228 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 990317001229 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 990317001230 metal-binding site [ion binding] 990317001231 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 990317001232 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 990317001233 motif II; other site 990317001234 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 990317001235 metal-binding site [ion binding] 990317001236 Predicted membrane protein [Function unknown]; Region: COG2860 990317001237 UPF0126 domain; Region: UPF0126; pfam03458 990317001238 UPF0126 domain; Region: UPF0126; pfam03458 990317001239 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 990317001240 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 990317001241 active site 990317001242 motif I; other site 990317001243 motif II; other site 990317001244 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 990317001245 Protein of unknown function (DUF2974); Region: DUF2974; pfam11187 990317001246 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 990317001247 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 990317001248 Uncharacterized protein conserved in bacteria [Function unknown]; Region: DegV; COG1307 990317001249 Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645 990317001250 Bacterial inner membrane protein; Region: Imp-YgjV; pfam10688 990317001251 Na+/phosphate symporter [Inorganic ion transport and metabolism]; Region: NptA; COG1283 990317001252 Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690 990317001253 Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690 990317001254 PhoU domain; Region: PhoU; pfam01895 990317001255 N-acetylglucosamine-6-phosphate deacetylase [Carbohydrate transport and metabolism]; Region: NagA; COG1820 990317001256 N-acetylglucosamine-6-phosphate deacetylase, NagA, catalyzes the hydrolysis of the N-acetyl group of N-acetyl-glucosamine-6-phosphate (GlcNAc-6-P) to glucosamine 6-phosphate and acetate. This is the first committed step in the biosynthetic pathway to...; Region: NagA; cd00854 990317001257 active site 990317001258 dimer interface [polypeptide binding]; other site 990317001259 Class II Glycyl-tRNA synthetase (GlyRS) alpha subunit core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes and in arabidopsis. It is responsible for the...; Region: GlyRS_alpha_core; cd00733 990317001260 dimer interface [polypeptide binding]; other site 990317001261 motif 1; other site 990317001262 active site 990317001263 motif 2; other site 990317001264 motif 3; other site 990317001265 glycyl-tRNA synthetase subunit beta; Validated; Region: glyS; PRK01233 990317001266 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 990317001267 hypothetical protein; Provisional; Region: PRK02539 990317001268 HTH domain; Region: HTH_11; pfam08279 990317001269 Transcriptional antiterminator [Transcription]; Region: BglG; COG3711 990317001270 Mga helix-turn-helix domain; Region: Mga; pfam05043 990317001271 PRD domain; Region: PRD; pfam00874 990317001272 PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568 990317001273 active site 990317001274 P-loop; other site 990317001275 phosphorylation site [posttranslational modification] 990317001276 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cl00163 990317001277 active site 990317001278 phosphorylation site [posttranslational modification] 990317001279 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 990317001280 active site 990317001281 phosphorylation site [posttranslational modification] 990317001282 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569 990317001283 active site 990317001284 P-loop; other site 990317001285 phosphorylation site [posttranslational modification] 990317001286 Phosphotransferase system, fructose-specific IIC component [Carbohydrate transport and metabolism]; Region: FruA; COG1299 990317001287 Phosphotransferase system, EIIC; Region: PTS_EIIC; pfam02378 990317001288 Pentose-5-phosphate-3-epimerase [Carbohydrate transport and metabolism]; Region: Rpe; COG0036 990317001289 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 990317001290 substrate binding site [chemical binding]; other site 990317001291 hexamer interface [polypeptide binding]; other site 990317001292 metal binding site [ion binding]; metal-binding site 990317001293 Transaldolase-like fructose-6-phosphate aldolases (FSA) found in bacteria and archaea; Region: Transaldolase_FSA; cd00956 990317001294 active site 990317001295 intersubunit interactions; other site 990317001296 catalytic residue [active] 990317001297 Transketolase [Carbohydrate transport and metabolism]; Region: TktA; COG0021 990317001298 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 990317001299 TPP-binding site [chemical binding]; other site 990317001300 dimer interface [polypeptide binding]; other site 990317001301 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 990317001302 PYR/PP interface [polypeptide binding]; other site 990317001303 dimer interface [polypeptide binding]; other site 990317001304 TPP binding site [chemical binding]; other site 990317001305 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 990317001306 Enterocin A Immunity; Region: EntA_Immun; pfam08951 990317001307 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 990317001308 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 990317001309 Walker A/P-loop; other site 990317001310 ATP binding site [chemical binding]; other site 990317001311 Q-loop/lid; other site 990317001312 ABC transporter signature motif; other site 990317001313 Walker B; other site 990317001314 D-loop; other site 990317001315 H-loop/switch region; other site 990317001316 PTS system, beta-glucoside-specific IIABC component; Region: PTS-II-ABC-beta; TIGR01995 990317001317 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 990317001318 active site turn [active] 990317001319 phosphorylation site [posttranslational modification] 990317001320 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 990317001321 Phosphotransferase system IIA components [Carbohydrate transport and metabolism]; Region: NagE; COG2190 990317001322 HPr interaction site; other site 990317001323 glycerol kinase (GK) interaction site [polypeptide binding]; other site 990317001324 active site 990317001325 phosphorylation site [posttranslational modification] 990317001326 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 990317001327 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 990317001328 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 990317001329 putative active site [active] 990317001330 Glycosyl hydrolase family 1; Region: Glyco_hydro_1; cl01046 990317001331 beta-galactosidase; Region: BGL; TIGR03356 990317001332 Glutamate 5-kinase [Amino acid transport and metabolism]; Region: ProB; COG0263 990317001333 AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242 990317001334 nucleotide binding site [chemical binding]; other site 990317001335 homotetrameric interface [polypeptide binding]; other site 990317001336 putative phosphate binding site [ion binding]; other site 990317001337 putative allosteric binding site; other site 990317001338 Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079 990317001339 gamma-glutamyl phosphate reductase; Region: proA; TIGR00407 990317001340 putative catalytic cysteine [active] 990317001341 Predicted S-adenosylmethionine-dependent methyltransferase involved in cell envelope biogenesis [Cell envelope biogenesis, outer membrane]; Region: COG0275 990317001342 MraW methylase family; Region: Methyltransf_5; pfam01795 990317001343 Protein required for the initiation of cell division [Cell division and chromosome partitioning]; Region: FtsL; COG4839 990317001344 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 990317001345 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 990317001346 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 990317001347 PASTA domain. This domain is found at the C-termini of several Penicillin-binding proteins (PBPs) and bacterial serine/threonine kinases. It is a small globular fold consisting of 3 beta-sheets and an alpha-helix. The name PASTA is derived from PBP and...; Region: PASTA; cl02768 990317001348 PASTA domain of PBP2x-like proteins, second repeat. Penicillin-binding proteins (PBPs) are the major targets for beta-lactam antibiotics, like penicillins and cephalosporins. Beta-lactam antibiotics specifically inhibit transpeptidase activity by...; Region: PASTA_Pbp2x-like_2; cd06575 990317001349 phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108 990317001350 Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852 990317001351 Mg++ binding site [ion binding]; other site 990317001352 putative catalytic motif [active] 990317001353 putative substrate binding site [chemical binding]; other site 990317001354 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 990317001355 DEAD-like helicases superfamily; Region: DEXDc; smart00487 990317001356 ATP binding site [chemical binding]; other site 990317001357 Mg++ binding site [ion binding]; other site 990317001358 motif III; other site 990317001359 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 990317001360 nucleotide binding region [chemical binding]; other site 990317001361 ATP-binding site [chemical binding]; other site 990317001362 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 990317001363 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 990317001364 substrate binding pocket [chemical binding]; other site 990317001365 membrane-bound complex binding site; other site 990317001366 hinge residues; other site 990317001367 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 990317001368 dimer interface [polypeptide binding]; other site 990317001369 conserved gate region; other site 990317001370 putative PBP binding loops; other site 990317001371 ABC-ATPase subunit interface; other site 990317001372 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 990317001373 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 990317001374 Walker A/P-loop; other site 990317001375 ATP binding site [chemical binding]; other site 990317001376 Q-loop/lid; other site 990317001377 ABC transporter signature motif; other site 990317001378 Walker B; other site 990317001379 D-loop; other site 990317001380 H-loop/switch region; other site 990317001381 Protein of unknown function (DUF4059); Region: DUF4059; pfam13268 990317001382 thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292 990317001383 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 990317001384 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 990317001385 nicotinate phosphoribosyltransferase; Validated; Region: PRK09243 990317001386 Nicotinate phosphoribosyltransferase (NAPRTase), subgroup A. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting, reaction...; Region: NAPRTase_A; cd01570 990317001387 active site 990317001388 NAD synthase [Coenzyme metabolism]; Region: NadE; COG0171 990317001389 NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553 990317001390 homodimer interface [polypeptide binding]; other site 990317001391 NAD binding pocket [chemical binding]; other site 990317001392 ATP binding pocket [chemical binding]; other site 990317001393 Mg binding site [ion binding]; other site 990317001394 active-site loop [active] 990317001395 Peptidase C1B subfamily (MEROPS database nomenclature); composed of eukaryotic bleomycin hydrolases (BH) and bacterial aminopeptidases C (pepC). The proteins of this subfamily contain a large insert relative to the C1A peptidase (papain) subfamily. BH is...; Region: Peptidase_C1B; cd00585 990317001396 trimer interface [polypeptide binding]; other site 990317001397 active site 990317001398 G bulge; other site 990317001399 Transglycosylase; Region: Transgly; pfam00912 990317001400 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 990317001401 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 990317001402 Holliday junction-specific endonuclease; Reviewed; Region: recU; PRK02234 990317001403 hypothetical protein; Provisional; Region: PRK13660 990317001404 cell division protein GpsB; Provisional; Region: PRK14127 990317001405 DivIVA domain; Region: DivI1A_domain; TIGR03544 990317001406 Predicted N6-adenine-specific DNA methylase [DNA replication, recombination, and repair]; Region: COG0116 990317001407 THUMP domain associated with S-adenosylmethionine-dependent methyltransferases; Region: THUMP_AdoMetMT; cd11715 990317001408 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 990317001409 acetoin reductase; Validated; Region: PRK08643 990317001410 meso-2,3-butanediol dehydrogenase-like, classical (c) SDRs; Region: meso-BDH-like_SDR_c; cd05366 990317001411 NAD binding site [chemical binding]; other site 990317001412 homotetramer interface [polypeptide binding]; other site 990317001413 homodimer interface [polypeptide binding]; other site 990317001414 active site 990317001415 substrate binding site [chemical binding]; other site 990317001416 S-ribosylhomocysteinase; Provisional; Region: PRK02260 990317001417 hypothetical protein; Provisional; Region: PRK00106 990317001418 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 990317001419 Zn2+ binding site [ion binding]; other site 990317001420 Mg2+ binding site [ion binding]; other site 990317001421 Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194 990317001422 Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071 990317001423 catalytic site [active] 990317001424 G-X2-G-X-G-K; other site 990317001425 DNA-directed RNA polymerase subunit omega; Reviewed; Region: rpoZ; PRK00392 990317001426 Primosomal protein N' (replication factor Y) - superfamily II helicase [DNA replication, recombination, and repair]; Region: PriA; COG1198 990317001427 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 990317001428 ATP binding site [chemical binding]; other site 990317001429 putative Mg++ binding site [ion binding]; other site 990317001430 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 990317001431 ATP-binding site [chemical binding]; other site 990317001432 methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005 990317001433 Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646 990317001434 putative active site [active] 990317001435 substrate binding site [chemical binding]; other site 990317001436 putative cosubstrate binding site; other site 990317001437 catalytic site [active] 990317001438 C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704 990317001439 substrate binding site [chemical binding]; other site 990317001440 16S rRNA methyltransferase B; Provisional; Region: PRK14902 990317001441 NusB family; Region: NusB; pfam01029 990317001442 putative RNA binding site [nucleotide binding]; other site 990317001443 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 990317001444 S-adenosylmethionine binding site [chemical binding]; other site 990317001445 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143 990317001446 active site 990317001447 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 990317001448 Catalytic domain of Protein Kinases; Region: PKc; cd00180 990317001449 active site 990317001450 ATP binding site [chemical binding]; other site 990317001451 substrate binding site [chemical binding]; other site 990317001452 activation loop (A-loop); other site 990317001453 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 990317001454 PASTA domain. This domain is found at the C-termini of several Penicillin-binding proteins (PBPs) and bacterial serine/threonine kinases. It is a small globular fold consisting of 3 beta-sheets and an alpha-helix. The name PASTA is derived from PBP and...; Region: PASTA; cl02768 990317001455 PASTA domain. This domain is found at the C-termini of several Penicillin-binding proteins (PBPs) and bacterial serine/threonine kinases. It is a small globular fold consisting of 3 beta-sheets and an alpha-helix. The name PASTA is derived from PBP and...; Region: PASTA; cl02768 990317001456 Predicted membrane protein [Function unknown]; Region: COG4758 990317001457 Cell wall-active antibiotics response protein (DUF2154); Region: DUF2154; pfam09922 990317001458 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 990317001459 Histidine kinase; Region: HisKA_3; pfam07730 990317001460 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 990317001461 ATP binding site [chemical binding]; other site 990317001462 Mg2+ binding site [ion binding]; other site 990317001463 G-X-G motif; other site 990317001464 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 990317001465 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 990317001466 active site 990317001467 phosphorylation site [posttranslational modification] 990317001468 intermolecular recognition site; other site 990317001469 dimerization interface [polypeptide binding]; other site 990317001470 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 990317001471 DNA binding residues [nucleotide binding] 990317001472 dimerization interface [polypeptide binding]; other site 990317001473 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 990317001474 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 990317001475 active site 990317001476 motif I; other site 990317001477 motif II; other site 990317001478 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cl17915 990317001479 active site 990317001480 motif I; other site 990317001481 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 990317001482 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317 990317001483 active site 990317001484 Predicted RNA binding protein (contains ribosomal protein S1 domain) [Translation, ribosomal structure and biogenesis]; Region: VacB; COG1098 990317001485 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cd00164 990317001486 RNA binding site [nucleotide binding]; other site 990317001487 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 990317001488 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 990317001489 dimer interface [polypeptide binding]; other site 990317001490 pyridoxal 5'-phosphate binding site [chemical binding]; other site 990317001491 catalytic residue [active] 990317001492 Uncharacterized conserved protein [Function unknown]; Region: COG1739 990317001493 Uncharacterized protein family UPF0029; Region: UPF0029; pfam01205 990317001494 Domain of unknown function (DUF1949); Region: DUF1949; pfam09186 990317001495 Superfamily II DNA/RNA helicase required for DNA uptake (late competence protein) [DNA replication, recombination, and repair]; Region: comFA; COG4098 990317001496 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 990317001497 ATP binding site [chemical binding]; other site 990317001498 putative Mg++ binding site [ion binding]; other site 990317001499 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 990317001500 nucleotide binding region [chemical binding]; other site 990317001501 ATP-binding site [chemical binding]; other site 990317001502 Predicted amidophosphoribosyltransferases [General function prediction only]; Region: ComFC; COG1040 990317001503 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 990317001504 active site 990317001505 RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552 990317001506 30S subunit binding site; other site 990317001507 Staphylococcal protein of unknown function (DUF960); Region: DUF960; pfam06124 990317001508 hypothetical protein; Provisional; Region: PRK13662 990317001509 recombination regulator RecX; Provisional; Region: recX; PRK14135 990317001510 TRAM domain; Region: TRAM; pfam01938 990317001511 SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase [Translation, ribosomal structure and biogenesis]; Region: TrmA; COG2265 990317001512 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 990317001513 S-adenosylmethionine binding site [chemical binding]; other site 990317001514 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 990317001515 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 990317001516 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 990317001517 Predicted peptidase [General function prediction only]; Region: COG4099 990317001518 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 990317001519 Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247 990317001520 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 990317001521 Coenzyme A binding pocket [chemical binding]; other site 990317001522 Nicotinamide mononucleotide transporter; Region: NMN_transporter; cl01256 990317001523 Deoxynucleoside kinases [Nucleotide transport and metabolism]; Region: COG1428 990317001524 Deoxyribonucleoside kinase (dNK) catalyzes the phosphorylation of deoxyribonucleosides to yield corresponding monophosphates (dNMPs). This family consists of various deoxynucleoside kinases including deoxyribo- cytidine (EC 2.7.1.74), guanosine (EC 2.7.1; Region: dNK; cd01673 990317001525 Substrate-binding site [chemical binding]; other site 990317001526 Substrate specificity [chemical binding]; other site 990317001527 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 990317001528 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 990317001529 Coenzyme A binding pocket [chemical binding]; other site 990317001530 Phosphorylase superfamily; Region: PNP_UDP_1; pfam01048 990317001531 Domain of unknown function (DUF1912); Region: DUF1912; pfam08930 990317001532 hypothetical protein; Provisional; Region: PRK07758 990317001533 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 990317001534 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 990317001535 AAA domain; Region: AAA_18; pfam13238 990317001536 Sulphate Transporter and Anti-Sigma factor antagonist domain found in the C-terminal region of sulphate transporters as well as in bacterial and archaeal proteins involved in the regulation of sigma factors; Region: STAS; cl00604 990317001537 valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729 990317001538 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 990317001539 active site 990317001540 HIGH motif; other site 990317001541 nucleotide binding site [chemical binding]; other site 990317001542 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 990317001543 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 990317001544 active site 990317001545 KMSKS motif; other site 990317001546 Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962 990317001547 tRNA binding surface [nucleotide binding]; other site 990317001548 anticodon binding site; other site 990317001549 Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458 990317001550 SIR2 superfamily of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+; Region: SIR2; cl00195 990317001551 Protein of unknown function (DUF419); Region: DUF419; cl15265 990317001552 H+ Antiporter protein; Region: 2A0121; TIGR00900 990317001553 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 990317001554 putative substrate translocation pore; other site 990317001555 probable dihydroxyacetone kinase regulator; Region: DHAK_reg; TIGR02366 990317001556 Transcriptional regulator C-terminal region; Region: TetR_C_8; pfam14278 990317001557 Asparagine synthetase A [Amino acid transport and metabolism]; Region: AsnA; COG2502 990317001558 motif 1; other site 990317001559 dimer interface [polypeptide binding]; other site 990317001560 active site 990317001561 motif 2; other site 990317001562 motif 3; other site 990317001563 HTH-like domain; Region: HTH_21; pfam13276 990317001564 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 990317001565 Integrase core domain; Region: rve; pfam00665 990317001566 Integrase core domain; Region: rve_2; pfam13333 990317001567 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 990317001568 Helix-turn-helix domain; Region: HTH_38; pfam13936 990317001569 V-type ATP synthase subunit I; Validated; Region: PRK05771 990317001570 N6-adenine-specific methylase [DNA replication, recombination, and repair]; Region: COG0742 990317001571 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 990317001572 S-adenosylmethionine binding site [chemical binding]; other site 990317001573 potential frameshift: common BLAST hit: gi|288904751|ref|YP_003429972.1| Phosphopantetheine adenylyltransferase 990317001574 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 990317001575 active site 990317001576 HIGH motif; other site 990317001577 nucleotide binding site [chemical binding]; other site 990317001578 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 990317001579 active site 990317001580 KMSKS motif; other site 990317001581 Predicted secreted protein containing a PDZ domain [Signal transduction mechanisms]; Region: SdrC; COG3480 990317001582 PDZ domain, also called DHR (Dlg homologous region) or GLGF (after a conserved sequence motif). Many PDZ domains bind C-terminal polypeptides, though binding to internal (non-C-terminal) polypeptides and even to lipids has been demonstrated; Region: PDZ; cl00117 990317001583 protein binding site [polypeptide binding]; other site 990317001584 Protein of unknown function (DUF3923); Region: DUF3923; pfam13061 990317001585 Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cl00200 990317001586 amphipathic channel; other site 990317001587 Asn-Pro-Ala signature motifs; other site 990317001588 Escherichia coli UshA-like family, N-terminal metallophosphatase domain; Region: MPP_UshA_N_like; cd00845 990317001589 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 990317001590 active site 990317001591 metal binding site [ion binding]; metal-binding site 990317001592 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 990317001593 Protein of unknown function (DUF1027); Region: DUF1027; cl09961 990317001594 ribosomal RNA large subunit methyltransferase N; Provisional; Region: PRK14455 990317001595 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 990317001596 FeS/SAM binding site; other site 990317001597 VanZ like family; Region: VanZ; pfam04892 990317001598 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 990317001599 putative multidrug transporter membrane\ATP-binding components; Provisional; Region: PRK10789 990317001600 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 990317001601 Walker A/P-loop; other site 990317001602 ATP binding site [chemical binding]; other site 990317001603 Q-loop/lid; other site 990317001604 ABC transporter signature motif; other site 990317001605 Walker B; other site 990317001606 D-loop; other site 990317001607 H-loop/switch region; other site 990317001608 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 990317001609 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 990317001610 ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254 990317001611 Walker A/P-loop; other site 990317001612 ATP binding site [chemical binding]; other site 990317001613 Q-loop/lid; other site 990317001614 ABC transporter signature motif; other site 990317001615 Walker B; other site 990317001616 D-loop; other site 990317001617 H-loop/switch region; other site 990317001618 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 990317001619 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 990317001620 Walker A/P-loop; other site 990317001621 ATP binding site [chemical binding]; other site 990317001622 Q-loop/lid; other site 990317001623 ABC transporter signature motif; other site 990317001624 Walker B; other site 990317001625 D-loop; other site 990317001626 H-loop/switch region; other site 990317001627 ABC-2 type transporter; Region: ABC2_membrane; cl17235 990317001628 ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698 990317001629 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 990317001630 Histidine kinase; Region: HisKA_3; pfam07730 990317001631 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 990317001632 ATP binding site [chemical binding]; other site 990317001633 Mg2+ binding site [ion binding]; other site 990317001634 G-X-G motif; other site 990317001635 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 990317001636 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 990317001637 active site 990317001638 phosphorylation site [posttranslational modification] 990317001639 intermolecular recognition site; other site 990317001640 dimerization interface [polypeptide binding]; other site 990317001641 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 990317001642 DNA binding residues [nucleotide binding] 990317001643 dimerization interface [polypeptide binding]; other site 990317001644 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4842 990317001645 WXG100 protein secretion system (Wss), protein EssA; Region: EssA; cl11266 990317001646 WXG100 protein secretion system (Wss), protein YukC; Region: YukC; cl01868 990317001647 type VII secretion protein EssC, C-terminal domain; Region: T7_EssCb_Firm; TIGR03928 990317001648 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 990317001649 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 990317001650 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061 990317001651 V-type ATP synthase subunit I; Validated; Region: PRK05771 990317001652 LXG domain of WXG superfamily; Region: LXG; pfam04740 990317001653 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 990317001654 CAAX protease self-immunity; Region: Abi; pfam02517 990317001655 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 990317001656 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 990317001657 Transcriptional regulator C-terminal region; Region: TetR_C_8; pfam14278 990317001658 Cna protein B-type domain; Region: Cna_B; pfam05738 990317001659 Repeat unit of collagen-binding protein domain B; Region: CollagenBindB; cd00222 990317001660 domain interaction interfaces [polypeptide binding]; other site 990317001661 Repeat unit of collagen-binding protein domain B; Region: CollagenBindB; cd00222 990317001662 domain interaction interfaces [polypeptide binding]; other site 990317001663 Repeat unit of collagen-binding protein domain B; Region: CollagenBindB; cd00222 990317001664 domain interaction interfaces [polypeptide binding]; other site 990317001665 Repeat unit of collagen-binding protein domain B; Region: CollagenBindB; cd00222 990317001666 domain interaction interfaces [polypeptide binding]; other site 990317001667 Repeat unit of collagen-binding protein domain B; Region: CollagenBindB; cd00222 990317001668 domain interaction interfaces [polypeptide binding]; other site 990317001669 Repeat unit of collagen-binding protein domain B; Region: CollagenBindB; cd00222 990317001670 domain interaction interfaces [polypeptide binding]; other site 990317001671 Protein of unknown function (DUF2089); Region: DUF2089; pfam09862 990317001672 TraX protein; Region: TraX; cl05434 990317001673 Predicted membrane protein [Function unknown]; Region: COG3371 990317001674 Chorismate mutase type II; Region: CM_2; smart00830 990317001675 anthranilate synthase component I; Provisional; Region: PRK13570 990317001676 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 990317001677 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 990317001678 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 990317001679 Glutamine amidotransferase class-I; Region: GATase; pfam00117 990317001680 glutamine binding [chemical binding]; other site 990317001681 catalytic triad [active] 990317001682 anthranilate phosphoribosyltransferase; Provisional; Region: trpD; PRK00188 990317001683 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 990317001684 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 990317001685 Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331 990317001686 active site 990317001687 ribulose/triose binding site [chemical binding]; other site 990317001688 phosphate binding site [ion binding]; other site 990317001689 substrate (anthranilate) binding pocket [chemical binding]; other site 990317001690 product (indole) binding pocket [chemical binding]; other site 990317001691 Phosphoribosylanthranilate isomerase (PRAI) catalyzes the fourth step of the tryptophan biosynthesis, the conversion of N-(5'- phosphoribosyl)-anthranilate (PRA) to 1-(o-carboxyphenylamino)- 1-deoxyribulose 5-phosphate (CdRP). Most PRAIs are...; Region: PRAI; cd00405 990317001692 active site 990317001693 tryptophan synthase, beta subunit; Region: trpB; TIGR00263 990317001694 Tryptophan synthase-beta: Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446 990317001695 pyridoxal 5'-phosphate binding site [chemical binding]; other site 990317001696 catalytic residue [active] 990317001697 Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724 990317001698 tryptophan synthase alpha subunit; Provisional; Region: trpA; CHL00200 990317001699 substrate binding site [chemical binding]; other site 990317001700 active site 990317001701 catalytic residues [active] 990317001702 heterodimer interface [polypeptide binding]; other site 990317001703 manganese transport protein MntH; Reviewed; Region: PRK00701 990317001704 Natural resistance-associated macrophage protein; Region: Nramp; pfam01566 990317001705 DNA-binding ferritin-like protein (oxidative damage protectant) [Inorganic ion transport and metabolism]; Region: Dps; COG0783 990317001706 DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043 990317001707 dimerization interface [polypeptide binding]; other site 990317001708 DPS ferroxidase diiron center [ion binding]; other site 990317001709 ion pore; other site 990317001710 Bacterial protein of unknown function (DUF910); Region: DUF910; pfam06014 990317001711 ROK family protein (putative glucokinase); Region: ROK_glcA_fam; TIGR00744 990317001712 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 990317001713 nucleotide binding site [chemical binding]; other site 990317001714 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 990317001715 active site residue [active] 990317001716 Alpha-galactosidase [Carbohydrate transport and metabolism]; Region: GalA; COG3345 990317001717 Melibiase; Region: Melibiase; pfam02065 990317001718 Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455 990317001719 Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455 990317001720 Phosphotransferase system, EIIC; Region: PTS_EIIC; pfam02378 990317001721 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 990317001722 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 990317001723 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 990317001724 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 990317001725 Predicted membrane GTPase involved in stress response [Signal transduction mechanisms]; Region: TypA; COG1217 990317001726 Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891 990317001727 G1 box; other site 990317001728 putative GEF interaction site [polypeptide binding]; other site 990317001729 GTP/Mg2+ binding site [chemical binding]; other site 990317001730 Switch I region; other site 990317001731 G2 box; other site 990317001732 G3 box; other site 990317001733 Switch II region; other site 990317001734 G4 box; other site 990317001735 G5 box; other site 990317001736 BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu. BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691 990317001737 BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants. BipA is a highly...; Region: BipA_TypA_C; cd03710 990317001738 Protein of unknown function (DUF3165); Region: DUF3165; pfam11364 990317001739 Alanine dehydrogenase/PNT, C-terminal domain; Region: AlaDh_PNT_C; smart01002 990317001740 UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK02472 990317001741 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 990317001742 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 990317001743 undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726 990317001744 MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785 990317001745 homodimer interface [polypeptide binding]; other site 990317001746 active site 990317001747 POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478 990317001748 Cell division protein FtsQ; Region: FtsQ; pfam03799 990317001749 Cell division ATPase FtsA [Cell division and chromosome partitioning]; Region: ftsA; COG0849 990317001750 Cell division protein FtsA; Region: FtsA; smart00842 990317001751 Cell division protein FtsA; Region: FtsA; pfam14450 990317001752 Domain of unknown function (DUF3484); Region: DUF3484; pfam11983 990317001753 cell division protein FtsZ; Validated; Region: PRK09330 990317001754 FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes. FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201 990317001755 nucleotide binding site [chemical binding]; other site 990317001756 SulA interaction site; other site 990317001757 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, YBL036c-like proteins; Region: PLPDE_III_YBL036c_like; cd00635 990317001758 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 990317001759 catalytic residue [active] 990317001760 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1799 990317001761 YGGT family; Region: YGGT; pfam02325 990317001762 Uncharacterized conserved protein, contains S4-like domain [Function unknown]; Region: COG2302 990317001763 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 990317001764 RNA binding surface [nucleotide binding]; other site 990317001765 DivIVA protein; Region: DivIVA; pfam05103 990317001766 DivIVA domain; Region: DivI1A_domain; TIGR03544 990317001767 isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK05743 990317001768 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 990317001769 active site 990317001770 HIGH motif; other site 990317001771 nucleotide binding site [chemical binding]; other site 990317001772 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 990317001773 active site 990317001774 KMSKS motif; other site 990317001775 Anticodon-binding domain of bacterial and eukaryotic mitochondrial isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_BEm; cd07960 990317001776 tRNA binding surface [nucleotide binding]; other site 990317001777 anticodon binding site; other site 990317001778 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 990317001779 Domain of unknown function (DUF1827); Region: DUF1827; pfam08860 990317001780 Contains a crystal structure of the Nudix hydrolase from Enterococcus faecalis, which has an unknown function. In general, members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes...; Region: Nudix_Hydrolase_25; cd04684 990317001781 nudix motif; other site 990317001782 ATP-binding subunits of Clp protease and DnaK/DnaJ chaperones [Posttranslational modification, protein turnover, chaperones]; Region: clpA; COG0542 990317001783 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 990317001784 Walker A motif; other site 990317001785 ATP binding site [chemical binding]; other site 990317001786 Walker B motif; other site 990317001787 arginine finger; other site 990317001788 UvrB/uvrC motif; Region: UVR; pfam02151 990317001789 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 990317001790 Walker A motif; other site 990317001791 ATP binding site [chemical binding]; other site 990317001792 Walker B motif; other site 990317001793 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 990317001794 Protein of unknown function (DUF3278); Region: DUF3278; pfam11683 990317001795 ornithine carbamoyltransferase; Validated; Region: PRK02102 990317001796 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 990317001797 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 990317001798 Protein of unknown function (DUF1797); Region: DUF1797; cl11550 990317001799 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 990317001800 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 990317001801 dimer interface [polypeptide binding]; other site 990317001802 conserved gate region; other site 990317001803 putative PBP binding loops; other site 990317001804 ABC-ATPase subunit interface; other site 990317001805 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 990317001806 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 990317001807 Walker A/P-loop; other site 990317001808 ATP binding site [chemical binding]; other site 990317001809 Q-loop/lid; other site 990317001810 ABC transporter signature motif; other site 990317001811 Walker B; other site 990317001812 D-loop; other site 990317001813 H-loop/switch region; other site 990317001814 This entry represents the core domain of the ferrous iron (Fe2+) transport protein FeoA found in bacteria; Region: FeoA; smart00899 990317001815 Fe2+ transport system protein A [Inorganic ion transport and metabolism]; Region: FeoA; COG1918 990317001816 Fe2+ transport system protein B [Inorganic ion transport and metabolism]; Region: FeoB; COG0370 990317001817 Ferrous iron transport protein B (FeoB) family; Region: FeoB; cd01879 990317001818 G1 box; other site 990317001819 GTP/Mg2+ binding site [chemical binding]; other site 990317001820 Switch I region; other site 990317001821 G2 box; other site 990317001822 G3 box; other site 990317001823 Switch II region; other site 990317001824 G4 box; other site 990317001825 G5 box; other site 990317001826 Nucleoside recognition; Region: Gate; pfam07670 990317001827 Ferrous iron transport protein B C terminus; Region: FeoB_C; pfam07664 990317001828 Nucleoside recognition; Region: Gate; pfam07670 990317001829 bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK14179 990317001830 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763 990317001831 NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080 990317001832 homodimer interface [polypeptide binding]; other site 990317001833 NADP binding site [chemical binding]; other site 990317001834 substrate binding site [chemical binding]; other site 990317001835 B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171 990317001836 putative substrate binding site [chemical binding]; other site 990317001837 putative ATP binding site [chemical binding]; other site 990317001838 Response regulator receiver domain; Region: Response_reg; pfam00072 990317001839 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 990317001840 active site 990317001841 phosphorylation site [posttranslational modification] 990317001842 intermolecular recognition site; other site 990317001843 dimerization interface [polypeptide binding]; other site 990317001844 LytTr DNA-binding domain; Region: LytTR; pfam04397 990317001845 Predicted signal transduction protein with a C-terminal ATPase domain [Signal transduction mechanisms]; Region: COG2972 990317001846 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 990317001847 Surface antigen [General function prediction only]; Region: COG3942 990317001848 CHAP domain; Region: CHAP; cl17642 990317001849 GBS Bsp-like repeat; Region: GBS_Bsp-like; pfam08481 990317001850 GBS Bsp-like repeat; Region: GBS_Bsp-like; pfam08481 990317001851 GBS Bsp-like repeat; Region: GBS_Bsp-like; pfam08481 990317001852 GBS Bsp-like repeat; Region: GBS_Bsp-like; pfam08481 990317001853 Bacterial SH3 domain; Region: SH3_5; pfam08460 990317001854 Gram-positive signal peptide, YSIRK family; Region: YSIRK_signal; TIGR01168 990317001855 Bacterial SH3 domain; Region: SH3_5; pfam08460 990317001856 GBS Bsp-like repeat; Region: GBS_Bsp-like; pfam08481 990317001857 Bacterial SH3 domain; Region: SH3_5; pfam08460 990317001858 GBS Bsp-like repeat; Region: GBS_Bsp-like; pfam08481 990317001859 GBS Bsp-like repeat; Region: GBS_Bsp-like; pfam08481 990317001860 GBS Bsp-like repeat; Region: GBS_Bsp-like; pfam08481 990317001861 GBS Bsp-like repeat; Region: GBS_Bsp-like; pfam08481 990317001862 Bacterial SH3 domain; Region: SH3_5; pfam08460 990317001863 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 990317001864 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 990317001865 exodeoxyribonuclease VII large subunit; Reviewed; Region: xseA; PRK00286 990317001866 ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489 990317001867 generic binding surface II; other site 990317001868 generic binding surface I; other site 990317001869 exodeoxyribonuclease VII small subunit; Provisional; Region: PRK00977 990317001870 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 990317001871 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 990317001872 substrate binding pocket [chemical binding]; other site 990317001873 chain length determination region; other site 990317001874 substrate-Mg2+ binding site; other site 990317001875 catalytic residues [active] 990317001876 aspartate-rich region 1; other site 990317001877 active site lid residues [active] 990317001878 aspartate-rich region 2; other site 990317001879 Predicted rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: COG1189 990317001880 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 990317001881 RNA binding surface [nucleotide binding]; other site 990317001882 FtsJ-like methyltransferase; Region: FtsJ; pfam01728 990317001883 Arginine repressor [Transcription]; Region: ArgR; COG1438 990317001884 Arginine repressor, DNA binding domain; Region: Arg_repressor; pfam01316 990317001885 Arginine repressor, C-terminal domain; Region: Arg_repressor_C; pfam02863 990317001886 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: RecN; COG0497 990317001887 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 990317001888 Walker A/P-loop; other site 990317001889 ATP binding site [chemical binding]; other site 990317001890 Q-loop/lid; other site 990317001891 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 990317001892 ABC transporter signature motif; other site 990317001893 Walker B; other site 990317001894 D-loop; other site 990317001895 H-loop/switch region; other site 990317001896 EDD domain protein, DegV family; Region: DegV; TIGR00762 990317001897 Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645 990317001898 Members of the SGNH-hydrolase superfamily, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase_YpmR_like; cd04506 990317001899 active site 990317001900 catalytic triad [active] 990317001901 oxyanion hole [active] 990317001902 Uncharacterized protein conserved in bacteria (DUF2140); Region: DUF2140; pfam09911 990317001903 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 990317001904 IHF dimer interface [polypeptide binding]; other site 990317001905 IHF - DNA interface [nucleotide binding]; other site 990317001906 amino acid/peptide transporter (Peptide:H+ symporter), bacterial; Region: yjdL_sub1_fam; TIGR00924 990317001907 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 990317001908 POT family; Region: PTR2; pfam00854 990317001909 dihydroorotate dehydrogenase (subfamily 1) family protein; Region: pyrD_sub1_fam; TIGR01037 990317001910 Dihydroorotate dehydrogenase (DHOD) class 1A FMN-binding domain. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine...; Region: DHOD_1A_like; cd04741 990317001911 active site 990317001912 FMN binding site [chemical binding]; other site 990317001913 substrate binding site [chemical binding]; other site 990317001914 catalytic residues [active] 990317001915 homodimer interface [polypeptide binding]; other site 990317001916 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 990317001917 Medium chain dehydrogenases/reductase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR5; cd08271 990317001918 putative NAD(P) binding site [chemical binding]; other site 990317001919 substrate binding site [chemical binding]; other site 990317001920 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 990317001921 dimerization interface [polypeptide binding]; other site 990317001922 putative DNA binding site [nucleotide binding]; other site 990317001923 putative Zn2+ binding site [ion binding]; other site 990317001924 heavy metal-(Cd/Co/Hg/Pb/Zn)-translocating P-type ATPase; Region: ATPase-IB2_Cd; TIGR01512 990317001925 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 990317001926 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 990317001927 motif I; other site 990317001928 motif II; other site 990317001929 Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism]; Region: EmrE; COG2076 990317001930 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 990317001931 catalytic core [active] 990317001932 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 990317001933 Cytotoxic translational repressor of toxin-antitoxin stability system [Translation, ribosomal structure and biogenesis / Cell division and chromosome partitioning]; Region: RelE; COG2026 990317001934 Protein of unknown function (DUF3267); Region: DUF3267; pfam11667 990317001935 Predicted small molecule binding protein (contains 3H domain) [General function prediction only]; Region: COG1827 990317001936 HTH domain; Region: HTH_11; pfam08279 990317001937 3H domain; Region: 3H; pfam02829 990317001938 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 990317001939 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 990317001940 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 990317001941 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 990317001942 recombination protein RecR; Reviewed; Region: recR; PRK00076 990317001943 RecR protein; Region: RecR; pfam02132 990317001944 TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR. RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025 990317001945 putative active site [active] 990317001946 putative metal-binding site [ion binding]; other site 990317001947 tetramer interface [polypeptide binding]; other site 990317001948 D-alanyl-alanine synthetase A; Reviewed; Region: ddl; PRK01966 990317001949 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 990317001950 D-ala D-ala ligase C-terminus; Region: Dala_Dala_lig_C; pfam07478 990317001951 ECF-type riboflavin transporter, S component; Region: ECF-ribofla_trS; cl17272 990317001952 UDP-N-acetylmuramyl pentapeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurF; COG0770 990317001953 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 990317001954 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 990317001955 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 990317001956 O-Antigen ligase; Region: Wzy_C; cl04850 990317001957 peptide chain release factor 3; Provisional; Region: prfC; PRK00741 990317001958 Release Factor 3 (RF3) protein involved in the terminal step of translocation in bacteria; Region: RF3; cd04169 990317001959 G1 box; other site 990317001960 putative GEF interaction site [polypeptide binding]; other site 990317001961 GTP/Mg2+ binding site [chemical binding]; other site 990317001962 Switch I region; other site 990317001963 G2 box; other site 990317001964 G3 box; other site 990317001965 Switch II region; other site 990317001966 G4 box; other site 990317001967 G5 box; other site 990317001968 RF3_II: this subfamily represents the domain II of bacterial Release Factor 3 (RF3). Termination of protein synthesis by the ribosome requires two release factor (RF) classes. The class II RF3 is a GTPase that removes class I RFs (RF1 or RF2) from the...; Region: RF3_II; cd03689 990317001969 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 990317001970 DEAD-like helicases superfamily; Region: DEXDc; smart00487 990317001971 ATP binding site [chemical binding]; other site 990317001972 Mg++ binding site [ion binding]; other site 990317001973 motif III; other site 990317001974 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 990317001975 nucleotide binding region [chemical binding]; other site 990317001976 ATP-binding site [chemical binding]; other site 990317001977 The GIY-YIG domain of uncharacterized protein family UPF0213 related to structure-specific endonuclease SLX1; Region: GIY-YIG_UPF0213; cd10456 990317001978 GIY-YIG motif/motif A; other site 990317001979 putative active site [active] 990317001980 putative metal binding site [ion binding]; other site 990317001981 Predicted O-methyltransferase [General function prediction only]; Region: COG4123 990317001982 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 990317001983 S-adenosylmethionine binding site [chemical binding]; other site 990317001984 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 990317001985 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 990317001986 putative acyl-acceptor binding pocket; other site 990317001987 SLBB domain; Region: SLBB; pfam10531 990317001988 comEA protein; Region: comE; TIGR01259 990317001989 Helix-hairpin-helix motif; Region: HHH; pfam00633 990317001990 Domain of unknown function (DUF4131); Region: DUF4131; pfam13567 990317001991 Predicted membrane metal-binding protein [General function prediction only]; Region: ComEC; COG0658 990317001992 Competence protein; Region: Competence; pfam03772 990317001993 Predicted hydrolase (metallo-beta-lactamase superfamily) [General function prediction only]; Region: ComEC; COG2333 990317001994 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 990317001995 YcfA-like protein; Region: YcfA; pfam07927 990317001996 Uncharacterized protein family (UPF0150); Region: UPF0150; pfam03681 990317001997 HD domain; Region: HD_3; pfam13023 990317001998 DNA polymerase III subunit delta; Reviewed; Region: holA; PRK05574 990317001999 DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144 990317002000 Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605 990317002001 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 990317002002 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 990317002003 hypothetical protein; Validated; Region: PRK00110 990317002004 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Provisional; Region: queA; PRK00147 990317002005 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Region: queA; TIGR00113 990317002006 CCC1-related family of proteins; Region: CCC1_like; cl00278 990317002007 VIT family; Region: VIT1; pfam01988 990317002008 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363 990317002009 GlcN6P_deaminase: Glucosamine-6-phosphate (GlcN6P) deaminase subfamily; GlcN6P deaminase catalyzes the reversible conversion of GlcN6P to D-fructose-6-phosphate (Fru6P) and ammonium. The reaction is an aldo-keto isomerization coupled with an amination or...; Region: GlcN6P_deaminase; cd01399 990317002010 active site 990317002011 trimer interface [polypeptide binding]; other site 990317002012 allosteric site; other site 990317002013 active site lid [active] 990317002014 hexamer (dimer of trimers) interface [polypeptide binding]; other site 990317002015 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 990317002016 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 990317002017 RNA binding surface [nucleotide binding]; other site 990317002018 Pseudouridine synthase, Escherichia coli RsuA like; Region: PseudoU_synth_RsuA; cd02553 990317002019 active site 990317002020 uracil binding [chemical binding]; other site 990317002021 Competence protein CoiA-like family; Region: CoiA; pfam06054 990317002022 Oligoendopeptidase F [Amino acid transport and metabolism]; Region: COG1164 990317002023 Peptidase family M3B Oligopeptidase F (PepF); Region: M3B_PepF_3; cd09608 990317002024 active site 990317002025 Zn binding site [ion binding]; other site 990317002026 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 990317002027 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 990317002028 Coenzyme A binding pocket [chemical binding]; other site 990317002029 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 990317002030 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 990317002031 motif II; other site 990317002032 Predicted O-methyltransferase [General function prediction only]; Region: COG4122 990317002033 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 990317002034 S-adenosylmethionine binding site [chemical binding]; other site 990317002035 foldase protein PrsA; Reviewed; Region: prsA; PRK01326 990317002036 alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252 990317002037 Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673 990317002038 motif 1; other site 990317002039 active site 990317002040 motif 2; other site 990317002041 motif 3; other site 990317002042 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 990317002043 DHHA1 domain; Region: DHHA1; pfam02272 990317002044 Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020 990317002045 active site 990317002046 Predicted amidohydrolase [General function prediction only]; Region: COG0388 990317002047 Uncharacterized subgroup of the nitrilase superfamily (putative class 13 nitrilases); Region: nitrilase_5; cd07583 990317002048 putative active site [active] 990317002049 catalytic triad [active] 990317002050 putative dimer interface [polypeptide binding]; other site 990317002051 transaminase; Reviewed; Region: PRK08068 990317002052 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 990317002053 pyridoxal 5'-phosphate binding site [chemical binding]; other site 990317002054 homodimer interface [polypeptide binding]; other site 990317002055 catalytic residue [active] 990317002056 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 990317002057 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 990317002058 Walker A/P-loop; other site 990317002059 ATP binding site [chemical binding]; other site 990317002060 Q-loop/lid; other site 990317002061 ABC transporter signature motif; other site 990317002062 Walker B; other site 990317002063 D-loop; other site 990317002064 H-loop/switch region; other site 990317002065 N-acetyl-gamma-glutamyl-phosphate reductase; Validated; Region: argC; PRK00436 990317002066 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 990317002067 Ornithine acetyltransferase (OAT) family; also referred to as ArgJ. OAT catalyzes the first and fifth steps in arginine biosynthesis, coupling acetylation of glutamate with deacetylation of N-acetylornithine, which allows recycling of the acetyl group in...; Region: OAT; cd02152 990317002068 heterotetramer interface [polypeptide binding]; other site 990317002069 active site pocket [active] 990317002070 cleavage site 990317002071 AAK_NAGK-like: N-Acetyl-L-glutamate kinase (NAGK)-like . Included in this CD are the Escherichia coli and Pseudomonas aeruginosa type NAGKs which catalyze the phosphorylation of N-acetyl-L-glutamate (NAG) by ATP in the second step of arginine...; Region: AAK_NAGK-like; cd04238 990317002072 nucleotide binding site [chemical binding]; other site 990317002073 N-acetyl-L-glutamate binding site [chemical binding]; other site 990317002074 acetylornithine aminotransferase; Provisional; Region: PRK04260 990317002075 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 990317002076 inhibitor-cofactor binding pocket; inhibition site 990317002077 pyridoxal 5'-phosphate binding site [chemical binding]; other site 990317002078 catalytic residue [active] 990317002079 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 990317002080 Transcriptional regulator [Transcription]; Region: LysR; COG0583 990317002081 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 990317002082 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 990317002083 dimerization interface [polypeptide binding]; other site 990317002084 Flavodoxin-like fold; Region: Flavodoxin_2; pfam02525 990317002085 YCII-related domain; Region: YCII; cl00999 990317002086 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 990317002087 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 990317002088 active site 990317002089 catalytic tetrad [active] 990317002090 Old yellow enzyme (OYE)-related FMN binding domain, group 4. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a reducing agent with oxygens, quinones, and alpha,beta-unsaturated aldehydes and ketones, and can act as...; Region: OYE_like_4_FMN; cd04735 990317002091 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 990317002092 putative active site [active] 990317002093 putative FMN binding site [chemical binding]; other site 990317002094 putative substrate binding site [chemical binding]; other site 990317002095 putative catalytic residue [active] 990317002096 Type 1 glutamine amidotransferase (GATase1)-like domain found in proteins similar to Escherichia coli Hsp31 protein; Region: GATase1_Hsp31_like; cd03141 990317002097 Putative intracellular protease/amidase [General function prediction only]; Region: ThiJ; COG0693 990317002098 potential catalytic triad [active] 990317002099 conserved cys residue [active] 990317002100 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 990317002101 Helix-Turn-Helix DNA binding domain of the MerR-like transcription regulators YyaN and YraB; Region: HTH_YyaN; cd01109 990317002102 DNA binding residues [nucleotide binding] 990317002103 putative dimer interface [polypeptide binding]; other site 990317002104 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3238 990317002105 Protein of unknown function, DUF606; Region: DUF606; pfam04657 990317002106 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 990317002107 non-specific DNA binding site [nucleotide binding]; other site 990317002108 salt bridge; other site 990317002109 sequence-specific DNA binding site [nucleotide binding]; other site 990317002110 Protein of unknown function (DUF3169); Region: DUF3169; pfam11368 990317002111 riboflavin biosynthesis protein RibD; Region: eubact_ribD; TIGR00326 990317002112 Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284 990317002113 catalytic motif [active] 990317002114 Zn binding site [ion binding]; other site 990317002115 RibD C-terminal domain; Region: RibD_C; pfam01872 990317002116 riboflavin synthase subunit alpha; Provisional; Region: PRK09289 990317002117 Lumazine binding domain; Region: Lum_binding; pfam00677 990317002118 Lumazine binding domain; Region: Lum_binding; pfam00677 990317002119 bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II protein; Provisional; Region: PRK09311 990317002120 3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; pfam00926 990317002121 GTP cyclohydrolase II (RibA). GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641 990317002122 dimerization interface [polypeptide binding]; other site 990317002123 active site 990317002124 lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209 990317002125 homopentamer interface [polypeptide binding]; other site 990317002126 active site 990317002127 Transcriptional regulator [Transcription]; Region: LysR; COG0583 990317002128 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 990317002129 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 990317002130 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 990317002131 active site 990317002132 catalytic tetrad [active] 990317002133 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 990317002134 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 990317002135 active site 990317002136 catalytic tetrad [active] 990317002137 CorA-like Mg2+ transporter protein; Region: CorA; pfam01544 990317002138 uncharacterized bacterial subfamily of the Escherichia coli CorA-Salmonella typhimurium ZntB family; Region: EcCorA_ZntB-like_u2; cd12827 990317002139 Cl binding site [ion binding]; other site 990317002140 oligomer interface [polypeptide binding]; other site 990317002141 metal ion transporter CorA-like divalent cation transporter superfamily; Region: MIT_CorA-like; cl00459 990317002142 Protein of unknown function (DUF1211); Region: DUF1211; cl01421 990317002143 Thiamine transporter protein (Thia_YuaJ); Region: Thia_YuaJ; pfam09515 990317002144 ribonucleotide-diphosphate reductase subunit beta; Provisional; Region: nrdF2; PRK13966 990317002145 Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049 990317002146 dimer interface [polypeptide binding]; other site 990317002147 putative radical transfer pathway; other site 990317002148 diiron center [ion binding]; other site 990317002149 tyrosyl radical; other site 990317002150 ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK07306 990317002151 Ribonucleotide reductase N-terminal; Region: RNR_N; pfam08343 990317002152 Class I ribonucleotide reductase; Region: RNR_I; cd01679 990317002153 active site 990317002154 dimer interface [polypeptide binding]; other site 990317002155 catalytic residues [active] 990317002156 effector binding site; other site 990317002157 R2 peptide binding site; other site 990317002158 NrdH-redoxin (NrdH) family; NrdH is a small monomeric protein with a conserved redox active CXXC motif within a TRX fold, characterized by a glutaredoxin (GRX)-like sequence and TRX-like activity profile. In vitro, it displays protein disulfide reductase...; Region: NrdH; cd02976 990317002159 catalytic residues [active] 990317002160 aconitate hydratase; Validated; Region: PRK09277 990317002161 Aconitase A catalytic domain; Region: AcnA_IRP; cd01586 990317002162 substrate binding site [chemical binding]; other site 990317002163 ligand binding site [chemical binding]; other site 990317002164 Aconitase A swivel domain. This is the major form of the TCA cycle enzyme aconitate hydratase, also known as aconitase and citrate hydro-lyase. It includes bacterial and archaeal aconitase A, and the eukaryotic cytosolic form of aconitase. This group...; Region: AcnA_IRP_Swivel; cd01580 990317002165 substrate binding site [chemical binding]; other site 990317002166 Bacillus subtilis (Bs) citrate synthase (CS)-II_like. CS catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the citric acid cycle (TCA or Krebs cycle). 2MCS catalyzes the...; Region: BSuCS-II_like; cd06110 990317002167 dimer interface [polypeptide binding]; other site 990317002168 Citrate synthase; Region: Citrate_synt; pfam00285 990317002169 active site 990317002170 citrylCoA binding site [chemical binding]; other site 990317002171 oxalacetate/citrate binding site [chemical binding]; other site 990317002172 coenzyme A binding site [chemical binding]; other site 990317002173 catalytic triad [active] 990317002174 Isocitrate/isopropylmalate dehydrogenase; Region: Iso_dh; cl00445 990317002175 isocitrate dehydrogenase; Validated; Region: PRK07362 990317002176 Predicted membrane protein [Function unknown]; Region: COG4905 990317002177 Protein of unknown function (DUF1113); Region: DUF1113; pfam06541 990317002178 The band 7 domain of flotillin (reggie) like proteins. This group contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin. Many of these band 7 domain-containing proteins are lipid raft-associated. Individual proteins of this...; Region: Band_7; cl02525 990317002179 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 990317002180 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 990317002181 active site 990317002182 motif I; other site 990317002183 motif II; other site 990317002184 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 990317002185 Transcriptional regulators [Transcription]; Region: PurR; COG1609 990317002186 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 990317002187 DNA binding site [nucleotide binding] 990317002188 domain linker motif; other site 990317002189 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 990317002190 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cl00630 990317002191 putative active site [active] 990317002192 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 990317002193 homotrimer interaction site [polypeptide binding]; other site 990317002194 putative active site [active] 990317002195 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3580 990317002196 2-hydroxyglutaryl-CoA dehydratase, D-component; Region: HGD-D; pfam06050 990317002197 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3581 990317002198 BadF/BadG/BcrA/BcrD ATPase family; Region: BcrAD_BadFG; cl17271 990317002199 Activator of 2-hydroxyglutaryl-CoA dehydratase (HSP70-class ATPase domain) [Lipid metabolism]; Region: COG1924 990317002200 BadF/BadG/BcrA/BcrD ATPase family; Region: BcrAD_BadFG; cl17271 990317002201 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 990317002202 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 990317002203 type VII secretion effector, SACOL2603 family; Region: T7SS_SACOL2603; TIGR04197 990317002204 LXG domain of WXG superfamily; Region: LXG; pfam04740 990317002205 Protein of unknown function (DUF1003); Region: DUF1003; pfam06210 990317002206 Domain of unknown function (DUF4118); Region: DUF4118; pfam13493 990317002207 GAF domain; Region: GAF_3; pfam13492 990317002208 Putative NodB-like catalytic domain of uncharacterized proteins found in bacteria; Region: CE4_COG4878; cd10924 990317002209 NodB motif; other site 990317002210 putative active site [active] 990317002211 putative catalytic site [active] 990317002212 putative Zn binding site [ion binding]; other site 990317002213 This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_3; cd03813 990317002214 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 990317002215 Predicted membrane protein [Function unknown]; Region: COG4267 990317002216 CotH protein; Region: CotH; pfam08757 990317002217 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 990317002218 Interdomain contacts; other site 990317002219 Cytokine receptor motif; other site 990317002220 Polyphosphate(polyP) polymerase domain of yeast vacuolar transport chaperone (VTC) proteins VTC-2, -3 and- 4, and similar proteins; Region: PolyPPase_VTC_like; cd07750 990317002221 putative metal binding residues [ion binding]; other site 990317002222 signature motif; other site 990317002223 dimer interface [polypeptide binding]; other site 990317002224 active site 990317002225 polyP binding site; other site 990317002226 substrate binding site [chemical binding]; other site 990317002227 acceptor-phosphate pocket; other site 990317002228 UDP-glucose 4-epimerase; Region: PLN02240 990317002229 UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247 990317002230 NAD binding site [chemical binding]; other site 990317002231 homodimer interface [polypeptide binding]; other site 990317002232 active site 990317002233 substrate binding site [chemical binding]; other site 990317002234 glmZ(sRNA)-inactivating NTPase; Provisional; Region: PRK05416 990317002235 conserved hypothetical protein, cofD-related; Region: CofD_related; TIGR01826 990317002236 Family of CofD-like proteins and proteins related to YvcK; Region: CofD_YvcK; cd07044 990317002237 dimer interface [polypeptide binding]; other site 990317002238 phosphate binding site [ion binding]; other site 990317002239 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1481 990317002240 Sporulation Regulator WhiA N terminal; Region: WhiA_N; pfam10298 990317002241 Peptidase family C69; Region: Peptidase_C69; pfam03577 990317002242 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 990317002243 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 990317002244 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 990317002245 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 990317002246 non-specific DNA binding site [nucleotide binding]; other site 990317002247 salt bridge; other site 990317002248 sequence-specific DNA binding site [nucleotide binding]; other site 990317002249 transcriptional activator, Rgg/GadR/MutR family, C-terminal domain; Region: RGG_Cterm; TIGR01716 990317002250 Metal binding protein AcdA. These proteins have been shown to function in the ABC uptake of Zn2+ and Mn2+ and in competence for genetic transformation and adhesion. The AcdA proteins belong to the TroA superfamily of helical backbone metal receptor...; Region: AdcA; cd01017 990317002251 Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297 990317002252 metal binding site [ion binding]; metal-binding site 990317002253 YodA lipocalin-like domain; Region: YodA; pfam09223 990317002254 Polyphosphate(polyP) polymerase domain of yeast vacuolar transport chaperone (VTC) proteins VTC-2, -3 and- 4, and similar proteins; Region: PolyPPase_VTC_like; cd07750 990317002255 putative metal binding residues [ion binding]; other site 990317002256 signature motif; other site 990317002257 dimer interface [polypeptide binding]; other site 990317002258 active site 990317002259 polyP binding site; other site 990317002260 substrate binding site [chemical binding]; other site 990317002261 acceptor-phosphate pocket; other site 990317002262 Mannosyl-glycoprotein endo-beta-N-acetylglucosaminidase; Region: Glucosaminidase; cl17361 990317002263 RelB antitoxin; Region: RelB; cl01171 990317002264 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3041; cl17396 990317002265 Plasmid recombination enzyme; Region: Mob_Pre; pfam01076 990317002266 Replication initiation factor; Region: Rep_trans; pfam02486 990317002267 Replication initiator protein A (RepA) N-terminus; Region: RepA_N; pfam06970 990317002268 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 990317002269 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 990317002270 non-specific DNA binding site [nucleotide binding]; other site 990317002271 salt bridge; other site 990317002272 sequence-specific DNA binding site [nucleotide binding]; other site 990317002273 Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582 990317002274 phiLC3 phage and phage-related integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes various bacterial (mainly gram positive) and phage integrases, including those similar to Lactococcus...; Region: INT_phiLC3_C; cd01189 990317002275 Int/Topo IB signature motif; other site 990317002276 50S ribosomal protein L31 type B; Reviewed; Region: rpmE2; PRK01678 990317002277 Exopolyphosphatase-related proteins [General function prediction only]; Region: COG0618 990317002278 DHH family; Region: DHH; pfam01368 990317002279 DHHA1 domain; Region: DHHA1; pfam02272 990317002280 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 990317002281 dimerization domain swap beta strand [polypeptide binding]; other site 990317002282 regulatory protein interface [polypeptide binding]; other site 990317002283 active site 990317002284 regulatory phosphorylation site [posttranslational modification]; other site 990317002285 Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism]; Region: PtsA; COG1080 990317002286 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 990317002287 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 990317002288 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 990317002289 NADP+-dependent non-phosphorylating glyceraldehyde 3-phosphate dehydrogenase and ALDH family 11; Region: ALDH_F11_NP-GAPDH; cd07082 990317002290 NADP-dependent glyceraldehyde-3-phosphate dehydrogenase; Provisional; Region: PLN00412 990317002291 tetrameric interface [polypeptide binding]; other site 990317002292 activator binding site; other site 990317002293 NADP binding site [chemical binding]; other site 990317002294 substrate binding site [chemical binding]; other site 990317002295 catalytic residues [active] 990317002296 Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and...; Region: PEPCK_HprK; cl00270 990317002297 active site 990317002298 metal-binding site [ion binding] 990317002299 active site 990317002300 nucleotide-binding site [chemical binding]; other site 990317002301 nucleotide-binding site [chemical binding]; other site 990317002302 Subtilisin-like serine proteases [Posttranslational modification, protein turnover, chaperones]; Region: AprE; COG1404 990317002303 Peptidase S8 family domain in Streptococcal C5a peptidases; Region: Peptidases_S8_C5a_Peptidase; cd07475 990317002304 putative active site [active] 990317002305 catalytic triad [active] 990317002306 PA_C5a_like: Protease-associated domain containing proteins like Streptococcus pyogenes C5a peptidase. This group contains various PA domain-containing proteins similar to S. pyogenes C5a, including, i) Vpr, a minor extracellular serine protease from...; Region: PA_C5a_like; cd02133 990317002307 PA/protease domain interface [polypeptide binding]; other site 990317002308 putative integrin binding motif; other site 990317002309 Peptidase S8 family domain in Streptococcal C5a peptidases; Region: Peptidases_S8_C5a_Peptidase; cd07475 990317002310 Fn3-like domain (DUF1034); Region: DUF1034; pfam06280 990317002311 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 990317002312 DEAD-like helicases superfamily; Region: DEXDc; smart00487 990317002313 ATP binding site [chemical binding]; other site 990317002314 putative Mg++ binding site [ion binding]; other site 990317002315 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 990317002316 nucleotide binding region [chemical binding]; other site 990317002317 ATP-binding site [chemical binding]; other site 990317002318 Uridine kinase [Nucleotide transport and metabolism]; Region: Udk; COG0572 990317002319 Uridine monophosphate kinase (UMPK, EC 2.7.1.48), also known as uridine kinase or uridine-cytidine kinase (UCK), catalyzes the reversible phosphoryl transfer from ATP to uridine or cytidine to yield UMP or CMP. In the primidine nucleotide-salvage pathway; Region: UMPK; cd02023 990317002320 Sugar specificity; other site 990317002321 Pyrimidine base specificity; other site 990317002322 ATP-binding site [chemical binding]; other site 990317002323 Listeria-Bacteroides repeat domain (List_Bact_rpt); Region: Flg_new; cl09714 990317002324 carbohydrate-binding modules from Bacteroides thetaiotaomicron SusE, SusF and similar proteins; Region: CBM_SusE-F_like; cl17376 990317002325 starch binding site [chemical binding]; other site 990317002326 Transcriptional regulators [Transcription]; Region: PurR; COG1609 990317002327 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 990317002328 DNA binding site [nucleotide binding] 990317002329 domain linker motif; other site 990317002330 N-terminal Early set domain associated with the catalytic domain of cyclomaltodextrinase and pullulan-degrading enzymes; Region: E_set_CDase_PDE_N; cd02857 990317002331 homodimer interface [polypeptide binding]; other site 990317002332 Alpha amylase catalytic domain found in cyclomaltodextrinases and related proteins; Region: AmyAc_CMD; cd11338 990317002333 active site 990317002334 homodimer interface [polypeptide binding]; other site 990317002335 catalytic site [active] 990317002336 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 990317002337 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 990317002338 dimer interface [polypeptide binding]; other site 990317002339 conserved gate region; other site 990317002340 putative PBP binding loops; other site 990317002341 ABC-ATPase subunit interface; other site 990317002342 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 990317002343 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 990317002344 dimer interface [polypeptide binding]; other site 990317002345 conserved gate region; other site 990317002346 putative PBP binding loops; other site 990317002347 ABC-ATPase subunit interface; other site 990317002348 Alpha amylase catalytic domain found in maltogenic amylases, cyclodextrin glycosyltransferase, and related proteins; Region: AmyAc_AmyMalt_CGTase_like; cd11320 990317002349 Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366 990317002350 Ca binding site [ion binding]; other site 990317002351 active site 990317002352 catalytic site [active] 990317002353 Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; cl02706 990317002354 IPT domain (domain D) of cyclodextrin glycosyltransferase (CGTase) and similar enzymes. These enzymes are involved in the enzymatic hydrolysis of alpha-1,4 linkages of starch polymers and belong to the glycosyl hydrolase family 13. Most consist of three...; Region: IPT_CGTD; cd00604 990317002355 The family 20 carbohydrate-binding module (CBM20), also known as the starch-binding domain, is found in a large number of starch degrading enzymes including alpha-amylase, beta-amylase, glucoamylase, and CGTase (cyclodextrin glucanotransferase). CBM20 is...; Region: CBM20; cl15347 990317002356 starch-binding site 2 [chemical binding]; other site 990317002357 starch-binding site 1 [chemical binding]; other site 990317002358 2-isopropylmalate synthase; Validated; Region: PRK00915 990317002359 2-isopropylmalate synthase (IPMS), N-terminal catalytic TIM barrel domain; Region: DRE_TIM_IPMS; cd07940 990317002360 active site 990317002361 catalytic residues [active] 990317002362 metal binding site [ion binding]; metal-binding site 990317002363 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; pfam08502 990317002364 3-isopropylmalate dehydrogenase; Provisional; Region: PRK00772 990317002365 tartrate dehydrogenase; Region: TTC; TIGR02089 990317002366 Predicted membrane protein [Function unknown]; Region: COG3326 990317002367 3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402 990317002368 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583 990317002369 substrate binding site [chemical binding]; other site 990317002370 ligand binding site [chemical binding]; other site 990317002371 isopropylmalate isomerase small subunit; Provisional; Region: leuD; PRK01641 990317002372 Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577 990317002373 substrate binding site [chemical binding]; other site 990317002374 GAF domain-containing protein [Signal transduction mechanisms]; Region: COG1956 990317002375 GAF domain; Region: GAF_2; pfam13185 990317002376 DNA polymerase III subunits gamma and tau; Validated; Region: PRK05563 990317002377 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 990317002378 Walker A motif; other site 990317002379 ATP binding site [chemical binding]; other site 990317002380 Walker B motif; other site 990317002381 arginine finger; other site 990317002382 DNA polymerase III subunits gamma and tau domain III; Region: DNA_pol3_gamma3; pfam12169 990317002383 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 990317002384 Helix-turn-helix domain; Region: HTH_38; pfam13936 990317002385 HTH-like domain; Region: HTH_21; pfam13276 990317002386 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 990317002387 Integrase core domain; Region: rve; pfam00665 990317002388 Integrase core domain; Region: rve_2; pfam13333 990317002389 bifunctional biotin--[acetyl-CoA-carboxylase] synthetase/biotin operon repressor; Provisional; Region: PRK11886 990317002390 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 990317002391 DNA-binding site [nucleotide binding]; DNA binding site 990317002392 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; pfam03099 990317002393 Biotin protein ligase C terminal domain; Region: BPL_C; pfam02237 990317002394 S-adenosylmethionine synthetase; Validated; Region: PRK05250 990317002395 S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438 990317002396 S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772 990317002397 S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773 990317002398 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 990317002399 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 990317002400 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 990317002401 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 990317002402 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 990317002403 hinge; other site 990317002404 active site 990317002405 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 990317002406 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 990317002407 Predicted transcriptional regulator containing CBS domains [Transcription]; Region: COG4109 990317002408 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 990317002409 DNA-binding site [nucleotide binding]; DNA binding site 990317002410 DRTGG domain; Region: DRTGG; pfam07085 990317002411 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 990317002412 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 990317002413 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 990317002414 active site 990317002415 Ribonuclease BN family enzyme [Replication, recombination, and repair]; Region: Rbn; COG1295 990317002416 Predicted membrane protein [Function unknown]; Region: COG2246 990317002417 GtrA-like protein; Region: GtrA; pfam04138 990317002418 Predicted membrane protein [Function unknown]; Region: COG4708 990317002419 NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956 990317002420 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114 990317002421 nucleotide binding pocket [chemical binding]; other site 990317002422 K-X-D-G motif; other site 990317002423 catalytic site [active] 990317002424 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 990317002425 NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119 990317002426 Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027 990317002427 Dimer interface [polypeptide binding]; other site 990317002428 BRCT sequence motif; other site 990317002429 putative lipid kinase; Reviewed; Region: PRK13055 990317002430 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 990317002431 Family 41 Carbohydrate-Binding Module from pullulanase-like enzymes; Region: CBM41_pullulanase; cd10315 990317002432 carbohydrate binding site [chemical binding]; other site 990317002433 pullulanase, type I; Region: pulA_typeI; TIGR02104 990317002434 Early set domain associated with the catalytic domain of pullulanase (also called dextrinase and alpha-dextrin endo-1,6-alpha glucosidase); Region: E_set_Pullulanase; cd02860 990317002435 Alpha amylase catalytic domain found in Pullulanase (also called dextrinase; alpha-dextrin endo-1,6-alpha glucosidase), limit dextrinase, and related proteins; Region: AmyAc_Pullulanase_LD-like; cd11341 990317002436 Ca binding site [ion binding]; other site 990317002437 active site 990317002438 catalytic site [active] 990317002439 glycogen branching enzyme; Provisional; Region: PRK12313 990317002440 N-terminal Early set domain associated with the catalytic domain of prokaryotic glycogen branching enzyme; Region: E_set_GBE_prok_N; cd02855 990317002441 Alpha amylase catalytic domain found in the Glycogen branching enzyme (also called 1,4-alpha-glucan branching enzyme); Region: AmyAc_Glg_BE; cd11322 990317002442 active site 990317002443 catalytic site [active] 990317002444 Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; pfam02806 990317002445 glucose-1-phosphate adenylyltransferase; Provisional; Region: glgC; PRK05293 990317002446 ADP-glucose pyrophosphorylase is involved in the biosynthesis of glycogen or starch; Region: ADP_Glucose_PP; cd02508 990317002447 ligand binding site; other site 990317002448 oligomer interface; other site 990317002449 Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651 990317002450 dimer interface [polypeptide binding]; other site 990317002451 N-terminal domain interface [polypeptide binding]; other site 990317002452 sulfate 1 binding site; other site 990317002453 glucose-1-phosphate adenylyltransferase, GlgD subunit; Region: glgD; TIGR02092 990317002454 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 990317002455 active site 990317002456 Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651 990317002457 dimer interface [polypeptide binding]; other site 990317002458 N-terminal domain interface [polypeptide binding]; other site 990317002459 sulfate 1 binding site; other site 990317002460 glycogen synthase; Provisional; Region: glgA; PRK00654 990317002461 This family is most closely related to the GT1 family of glycosyltransferases. Glycogen synthase catalyzes the formation and elongation of the alpha-1,4-glucose backbone using ADP-glucose, the second and key step of glycogen biosynthesis. This family...; Region: GT1_Glycogen_synthase_DULL1_like; cd03791 990317002462 ADP-binding pocket [chemical binding]; other site 990317002463 homodimer interface [polypeptide binding]; other site 990317002464 This is a family of oligosaccharide phosphorylases. It includes yeast and mammalian glycogen phosphorylases, plant starch/glucan phosphorylase, as well as the maltodextrin phosphorylases of bacteria. The members of this family catalyze the breakdown of...; Region: GT1_Glycogen_Phosphorylase; cd04300 990317002465 homodimer interface [polypeptide binding]; other site 990317002466 glycogen/starch/alpha-glucan phosphorylases; Region: P_ylase; TIGR02093 990317002467 active site pocket [active] 990317002468 F0F1 ATP synthase subunit C; Provisional; Region: PRK13467 990317002469 F0F1-type ATP synthase, subunit a [Energy production and conversion]; Region: AtpB; COG0356 990317002470 F0F1 ATP synthase subunit A; Validated; Region: PRK05815 990317002471 F0F1-type ATP synthase, subunit b [Energy production and conversion]; Region: AtpF; COG0711 990317002472 F0F1 ATP synthase subunit B; Validated; Region: PRK05759 990317002473 F0F1 ATP synthase subunit delta; Validated; Region: PRK05758 990317002474 ATP synthase delta (OSCP) subunit; Region: OSCP; pfam00213 990317002475 F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281 990317002476 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 990317002477 F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132 990317002478 beta subunit interaction interface [polypeptide binding]; other site 990317002479 Walker A motif; other site 990317002480 ATP binding site [chemical binding]; other site 990317002481 Walker B motif; other site 990317002482 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 990317002483 mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151 990317002484 core domain interface [polypeptide binding]; other site 990317002485 delta subunit interface [polypeptide binding]; other site 990317002486 epsilon subunit interface [polypeptide binding]; other site 990317002487 F0F1 ATP synthase subunit beta; Validated; Region: PRK09280 990317002488 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 990317002489 F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133 990317002490 alpha subunit interaction interface [polypeptide binding]; other site 990317002491 Walker A motif; other site 990317002492 ATP binding site [chemical binding]; other site 990317002493 Walker B motif; other site 990317002494 inhibitor binding site; inhibition site 990317002495 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 990317002496 F0F1 ATP synthase subunit epsilon; Validated; Region: atpC; PRK00571 990317002497 mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152 990317002498 gamma subunit interface [polypeptide binding]; other site 990317002499 epsilon subunit interface [polypeptide binding]; other site 990317002500 LBP interface [polypeptide binding]; other site 990317002501 Protein of unknown function (DUF1146); Region: DUF1146; cl11486 990317002502 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 990317002503 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 990317002504 hinge; other site 990317002505 active site 990317002506 DNA-directed RNA polymerase subunit beta; Region: EpuA; pfam11772 990317002507 DNA/RNA non-specific endonuclease; Region: Endonuclease_NS; smart00892 990317002508 DNA/RNA non-specific endonuclease; Region: Endonuclease_NS; pfam01223 990317002509 phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488 990317002510 Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912 990317002511 Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496 990317002512 dimer interface [polypeptide binding]; other site 990317002513 motif 1; other site 990317002514 active site 990317002515 motif 2; other site 990317002516 motif 3; other site 990317002517 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 990317002518 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 990317002519 Coenzyme A binding pocket [chemical binding]; other site 990317002520 phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629 990317002521 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 990317002522 putative tRNA-binding site [nucleotide binding]; other site 990317002523 B3/4 domain; Region: B3_4; pfam03483 990317002524 tRNA synthetase B5 domain; Region: B5; smart00874 990317002525 Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA, PheRS is an...; Region: PheRS_beta_core; cd00769 990317002526 dimer interface [polypeptide binding]; other site 990317002527 motif 1; other site 990317002528 motif 3; other site 990317002529 motif 2; other site 990317002530 Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; smart00896 990317002531 potential frameshift: common BLAST hit: gi|288905007|ref|YP_003430229.1| ATP-dependent deoxyribonuclease (subunit B) 990317002532 ATP-dependent nuclease subunit B; Region: rexB_recomb; TIGR02774 990317002533 ATP-dependent nuclease subunit B; Region: rexB_recomb; TIGR02774 990317002534 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 990317002535 helicase-exonuclease AddAB, AddA subunit, Firmicutes type; Region: addA_Gpos; TIGR02785 990317002536 Family description; Region: UvrD_C_2; pfam13538 990317002537 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 990317002538 CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311 990317002539 substrate binding site [chemical binding]; other site 990317002540 THF binding site; other site 990317002541 zinc-binding site [ion binding]; other site 990317002542 hypothetical protein; Provisional; Region: PRK07329 990317002543 Polymerase and Histidinol Phosphatase domain; Region: PHP; cl17102 990317002544 active site 990317002545 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 990317002546 Protein of unknown function (DUF3042); Region: DUF3042; pfam11240 990317002547 tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091 990317002548 tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324 990317002549 GTP-binding protein HflX; Region: GTP_HflX; TIGR03156 990317002550 GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167 990317002551 HflX GTPase family; Region: HflX; cd01878 990317002552 G1 box; other site 990317002553 GTP/Mg2+ binding site [chemical binding]; other site 990317002554 Switch I region; other site 990317002555 G2 box; other site 990317002556 G3 box; other site 990317002557 Switch II region; other site 990317002558 G4 box; other site 990317002559 G5 box; other site 990317002560 Galactose-1-phosphate uridyl transferase, N-terminal domain; Region: GalP_UDP_transf; pfam01087 990317002561 ribonuclease Z; Region: RNase_Z; TIGR02651 990317002562 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 990317002563 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 990317002564 NAD(P) binding site [chemical binding]; other site 990317002565 active site 990317002566 single-stranded-DNA-specific exonuclease RecJ; Region: recJ; TIGR00644 990317002567 DHH family; Region: DHH; pfam01368 990317002568 Single-strand DNA-specific exonuclease, C terminal domain; Region: ssDNA-exonuc_C; pfam10141 990317002569 CAAX protease self-immunity; Region: Abi; pfam02517 990317002570 Linear amide C-N hydrolases, choloylglycine hydrolase family; Region: CBAH; pfam02275 990317002571 Penicillin V acylase (PVA), also known as conjugated bile salt acid hydrolase (CBAH), catalyzes the hydrolysis of penicillin V to yield 6-amino penicillanic acid (6-APA), an important key intermediate of semisynthetic penicillins. PVA has an N-terminal...; Region: Ntn_PVA; cd00542 990317002572 active site 990317002573 DinB superfamily; Region: DinB_2; pfam12867 990317002574 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 990317002575 ATP-binding cassette domain of the lipid transporters, subfamily A; Region: ABC_subfamily_A; cd03263 990317002576 Walker A/P-loop; other site 990317002577 ATP binding site [chemical binding]; other site 990317002578 Q-loop/lid; other site 990317002579 ABC transporter signature motif; other site 990317002580 Walker B; other site 990317002581 D-loop; other site 990317002582 H-loop/switch region; other site 990317002583 ABC-type Na+ efflux pump, permease component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatB; COG1668 990317002584 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 990317002585 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 990317002586 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 990317002587 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 990317002588 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 990317002589 active site 990317002590 homoserine O-succinyltransferase; Provisional; Region: PRK05368 990317002591 Type 1 glutamine amidotransferase (GATase1)-like domain found in homoserine trans-succinylase (HTS); Region: GATase1_HTS; cd03131 990317002592 proposed active site lysine [active] 990317002593 conserved cys residue [active] 990317002594 Putative primosome component and related proteins [DNA replication, recombination, and repair]; Region: DnaD; COG3935 990317002595 Replication initiation and membrane attachment; Region: DnaB_2; pfam07261 990317002596 Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177 990317002597 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 990317002598 minor groove reading motif; other site 990317002599 helix-hairpin-helix signature motif; other site 990317002600 substrate binding pocket [chemical binding]; other site 990317002601 active site 990317002602 iron-sulpphur binding domain in DNA-(apurinic or apyrimidinic site) lyase (subfamily of ENDO3); Region: FES; smart00525 990317002603 Predicted SAM-dependent methyltransferase [General function prediction only]; Region: COG2384 990317002604 Family of unknown function (DUF633); Region: DUF633; pfam04816 990317002605 Uncharacterized conserved protein [Function unknown]; Region: COG0327 990317002606 NIF3 (NGG1p interacting factor 3); Region: NIF3; pfam01784 990317002607 G1P_TT_short is the short form of glucose-1-phosphate thymidylyltransferase; Region: G1P_TT_short; cd02538 990317002608 glucose-1-phosphate thymidylyltransferase, short form; Region: rmlA; TIGR01207 990317002609 substrate binding site; other site 990317002610 tetramer interface; other site 990317002611 dTDP-4-dehydrorhamnose 3,5-epimerase and related enzymes [Cell envelope biogenesis, outer membrane]; Region: RfbC; COG1898 990317002612 dTDP-D-glucose 4,6-dehydratase [Cell envelope biogenesis, outer membrane]; Region: RfbB; COG1088 990317002613 dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246 990317002614 NAD binding site [chemical binding]; other site 990317002615 substrate binding site [chemical binding]; other site 990317002616 homodimer interface [polypeptide binding]; other site 990317002617 active site 990317002618 HD domain; Region: HD_4; pfam13328 990317002619 MutT homolog-1 (MTH1) is a member of the Nudix hydrolase superfamily. MTH1, the mammalian counterpart of MutT, hydrolyzes oxidized purine nucleoside triphosphates, such as 8-oxo-dGTP and 2-hydroxy-ATP, to monophosphates, thereby preventing the...; Region: MTH1; cd03427 990317002620 putative active site [active] 990317002621 nucleotide binding site [chemical binding]; other site 990317002622 nudix motif; other site 990317002623 putative metal binding site [ion binding]; other site 990317002624 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 990317002625 Domain of unknown function DUF20; Region: UPF0118; pfam01594 990317002626 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 990317002627 TPR motif; other site 990317002628 binding surface 990317002629 Tetratricopeptide repeat; Region: TPR_12; pfam13424 990317002630 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 990317002631 binding surface 990317002632 TPR motif; other site 990317002633 Anaphase-promoting complex, cyclosome, subunit 3; Region: Apc3; pfam12895 990317002634 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 990317002635 dimerization interface [polypeptide binding]; other site 990317002636 putative DNA binding site [nucleotide binding]; other site 990317002637 putative Zn2+ binding site [ion binding]; other site 990317002638 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 990317002639 Old yellow enzyme (OYE)-related FMN binding domain, group 4. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a reducing agent with oxygens, quinones, and alpha,beta-unsaturated aldehydes and ketones, and can act as...; Region: OYE_like_4_FMN; cd04735 990317002640 putative active site [active] 990317002641 putative FMN binding site [chemical binding]; other site 990317002642 putative substrate binding site [chemical binding]; other site 990317002643 putative catalytic residue [active] 990317002644 acetolactate synthase; Reviewed; Region: PRK08617 990317002645 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 990317002646 PYR/PP interface [polypeptide binding]; other site 990317002647 dimer interface [polypeptide binding]; other site 990317002648 TPP binding site [chemical binding]; other site 990317002649 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 990317002650 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629 990317002651 TPP-binding site [chemical binding]; other site 990317002652 Alpha-acetolactate decarboxylase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: AlsD; COG3527 990317002653 amino acid transporter; Region: 2A0306; TIGR00909 990317002654 C-terminus of AA_permease; Region: AA_permease_C; pfam13906 990317002655 Fibronectin-binding protein A N-terminus (FbpA); Region: FbpA; pfam05833 990317002656 Domain of unknown function (DUF814); Region: DUF814; pfam05670 990317002657 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 990317002658 Transcriptional regulator [Transcription]; Region: LysR; COG0583 990317002659 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 990317002660 dimerization interface [polypeptide binding]; other site 990317002661 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 990317002662 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 990317002663 Walker A/P-loop; other site 990317002664 ATP binding site [chemical binding]; other site 990317002665 Q-loop/lid; other site 990317002666 ABC transporter signature motif; other site 990317002667 Walker B; other site 990317002668 D-loop; other site 990317002669 H-loop/switch region; other site 990317002670 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 990317002671 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 990317002672 dimer interface [polypeptide binding]; other site 990317002673 conserved gate region; other site 990317002674 putative PBP binding loops; other site 990317002675 ABC-ATPase subunit interface; other site 990317002676 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 990317002677 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 990317002678 substrate binding pocket [chemical binding]; other site 990317002679 membrane-bound complex binding site; other site 990317002680 hinge residues; other site 990317002681 N-Dimethylarginine dimethylaminohydrolase [Amino acid transport and metabolism]; Region: COG1834 990317002682 Amidinotransferase; Region: Amidinotransf; pfam02274 990317002683 Histidinol-phosphate/aromatic aminotransferase and cobyric acid decarboxylase [Amino acid transport and metabolism]; Region: HisC; COG0079 990317002684 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 990317002685 pyridoxal 5'-phosphate binding site [chemical binding]; other site 990317002686 homodimer interface [polypeptide binding]; other site 990317002687 catalytic residue [active] 990317002688 Formate/glycerate dehydrogenases, D-specific 2-hydroxy acid dehydrogenases and related dehydrogenases; Region: FDH_GDH_like; cl17240 990317002689 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052 990317002690 NAD binding site [chemical binding]; other site 990317002691 M20 Peptidase Arginine utilization protein, RocB; Region: M20_ArgE_RocB; cd05654 990317002692 putative metal binding site [ion binding]; other site 990317002693 putative dimer interface [polypeptide binding]; other site 990317002694 Type I periplasmic ligand-binding domain of uncharacterized ABC-type transport systems that are predicted to be involved in the uptake of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_uncharacterized_transporter; cd06325 990317002695 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 990317002696 zinc binding site [ion binding]; other site 990317002697 putative ligand binding site [chemical binding]; other site 990317002698 Transmembrane subunit (TM) of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which are involved in the uptake of branched-chain amino acids (AAs), as well as TMs of transporters involved in the uptake of...; Region: TM_PBP1_branched-chain-AA_like; cd06574 990317002699 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 990317002700 TM-ABC transporter signature motif; other site 990317002701 ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: PhnK; COG1101 990317002702 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 990317002703 Walker A/P-loop; other site 990317002704 ATP binding site [chemical binding]; other site 990317002705 Q-loop/lid; other site 990317002706 ABC transporter signature motif; other site 990317002707 Walker B; other site 990317002708 D-loop; other site 990317002709 H-loop/switch region; other site 990317002710 type VII secretion effector, SACOL2603 family; Region: T7SS_SACOL2603; TIGR04197 990317002711 mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595 990317002712 Metallo-beta-lactamase superfamily; Region: Lactamase_B; pfam00753 990317002713 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 990317002714 Zinc-dependent metalloprotease, MMP_like subfamily. This group contains matrix metalloproteinases (MMPs), serralysins, and the astacin_like family of proteases; Region: ZnMc_MMP_like; cd04268 990317002715 active site 990317002716 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 990317002717 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 990317002718 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 990317002719 ABC transporter; Region: ABC_tran_2; pfam12848 990317002720 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 990317002721 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 990317002722 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 990317002723 non-specific DNA binding site [nucleotide binding]; other site 990317002724 salt bridge; other site 990317002725 sequence-specific DNA binding site [nucleotide binding]; other site 990317002726 transcriptional activator, Rgg/GadR/MutR family, C-terminal domain; Region: RGG_Cterm; TIGR01716 990317002727 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 990317002728 putative substrate translocation pore; other site 990317002729 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 990317002730 MarR family; Region: MarR_2; pfam12802 990317002731 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 990317002732 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 990317002733 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 990317002734 Walker A/P-loop; other site 990317002735 ATP binding site [chemical binding]; other site 990317002736 Q-loop/lid; other site 990317002737 ABC transporter signature motif; other site 990317002738 Walker B; other site 990317002739 D-loop; other site 990317002740 H-loop/switch region; other site 990317002741 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 990317002742 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 990317002743 ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254 990317002744 Walker A/P-loop; other site 990317002745 ATP binding site [chemical binding]; other site 990317002746 Q-loop/lid; other site 990317002747 ABC transporter signature motif; other site 990317002748 Walker B; other site 990317002749 D-loop; other site 990317002750 H-loop/switch region; other site 990317002751 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, alpha subunit [Energy production and conversion]; Region: AcoA; COG1071 990317002752 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 990317002753 tetramer interface [polypeptide binding]; other site 990317002754 TPP-binding site [chemical binding]; other site 990317002755 heterodimer interface [polypeptide binding]; other site 990317002756 phosphorylation loop region [posttranslational modification] 990317002757 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 990317002758 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 990317002759 alpha subunit interface [polypeptide binding]; other site 990317002760 TPP binding site [chemical binding]; other site 990317002761 heterodimer interface [polypeptide binding]; other site 990317002762 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 990317002763 branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856 990317002764 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 990317002765 E3 interaction surface; other site 990317002766 lipoyl attachment site [posttranslational modification]; other site 990317002767 e3 binding domain; Region: E3_binding; pfam02817 990317002768 e3 binding domain; Region: E3_binding; pfam02817 990317002769 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 990317002770 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 990317002771 E3 interaction surface; other site 990317002772 lipoyl attachment site [posttranslational modification]; other site 990317002773 dihydrolipoamide dehydrogenase; Region: lipoamide_DH; TIGR01350 990317002774 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 990317002775 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 990317002776 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 990317002777 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 990317002778 ABC-ATPase subunit interface; other site 990317002779 dimer interface [polypeptide binding]; other site 990317002780 putative PBP binding regions; other site 990317002781 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 990317002782 ABC-ATPase subunit interface; other site 990317002783 dimer interface [polypeptide binding]; other site 990317002784 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 990317002785 putative PBP binding regions; other site 990317002786 ABC-type enterochelin transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CeuD; COG4604 990317002787 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 990317002788 Walker A/P-loop; other site 990317002789 ATP binding site [chemical binding]; other site 990317002790 Q-loop/lid; other site 990317002791 ABC transporter signature motif; other site 990317002792 Walker B; other site 990317002793 D-loop; other site 990317002794 H-loop/switch region; other site 990317002795 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 990317002796 Siderophore binding protein FatB. These proteins have been shown to function as ABC-type initial receptors in the siderophore-mediated iron uptake in some eubacterial species. They belong to the TroA superfamily of periplasmic metal binding proteins...; Region: FatB; cd01140 990317002797 putative ligand binding residues [chemical binding]; other site 990317002798 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 990317002799 EamA-like transporter family; Region: EamA; pfam00892 990317002800 EamA-like transporter family; Region: EamA; pfam00892 990317002801 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 990317002802 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 990317002803 DNA-binding site [nucleotide binding]; DNA binding site 990317002804 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 990317002805 pyridoxal 5'-phosphate binding site [chemical binding]; other site 990317002806 homodimer interface [polypeptide binding]; other site 990317002807 catalytic residue [active] 990317002808 Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095 990317002809 lipoyltransferase and lipoate-protein ligase; Region: lipoyltrans; TIGR00545 990317002810 Bacterial lipoate protein ligase C-terminus; Region: Lip_prot_lig_C; pfam10437 990317002811 Host cell surface-exposed lipoprotein; Region: Lipoprotein_Ltp; pfam07553 990317002812 Host cell surface-exposed lipoprotein; Region: Lipoprotein_Ltp; pfam07553 990317002813 Transcriptional regulator [Transcription]; Region: LysR; COG0583 990317002814 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 990317002815 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 990317002816 dimerization interface [polypeptide binding]; other site 990317002817 Protein of unknown function (DUF3737); Region: DUF3737; pfam12541 990317002818 Bifunctional PLP-dependent enzyme with beta-cystathionase and maltose regulon repressor activities [Amino acid transport and metabolism]; Region: MalY; COG1168 990317002819 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 990317002820 pyridoxal 5'-phosphate binding site [chemical binding]; other site 990317002821 homodimer interface [polypeptide binding]; other site 990317002822 catalytic residue [active] 990317002823 Uncharacterized conserved protein [Function unknown]; Region: COG4925 990317002824 Uncharacterized conserved protein [Function unknown]; Region: COG4925 990317002825 Predicted flavin-nucleotide-binding protein [General function prediction only]; Region: COG3467 990317002826 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Thermotoga marina NorM; Region: MATE_NorM_like; cd13137 990317002827 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 990317002828 Pyrimidine reductase, riboflavin biosynthesis [Coenzyme metabolism]; Region: RibD; COG1985 990317002829 RibD C-terminal domain; Region: RibD_C; cl17279 990317002830 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 990317002831 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 990317002832 putative substrate translocation pore; other site 990317002833 Hydrolases of the alpha/beta superfamily [General function prediction only]; Region: COG1073 990317002834 Domain of unknown function (DUF4353); Region: DUF4353; pfam14262 990317002835 Domain of unknown function (DUF4353); Region: DUF4353; pfam14262 990317002836 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 990317002837 Major Facilitator Superfamily; Region: MFS_1; pfam07690 990317002838 putative substrate translocation pore; other site 990317002839 flavocytochrome c; Region: flavo_cyto_c; TIGR01813 990317002840 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 990317002841 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 990317002842 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 990317002843 Predicted flavoprotein [General function prediction only]; Region: COG0431 990317002844 Predicted flavoprotein [General function prediction only]; Region: COG0431 990317002845 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 990317002846 hypothetical protein; Provisional; Region: PRK04143 990317002847 ADP-ribose binding site [chemical binding]; other site 990317002848 Transcriptional regulators CsoR (copper-sensitive operon repressor), RcnR, and FrmR, and related domains; this domain superfamily was previously known as DUF156; Region: CsoR-like_DUF156; cl00846 990317002849 putative homotetramer interface [polypeptide binding]; other site 990317002850 putative homodimer interface [polypeptide binding]; other site 990317002851 putative allosteric switch controlling residues; other site 990317002852 putative metal binding site [ion binding]; other site 990317002853 putative homodimer-homodimer interface [polypeptide binding]; other site 990317002854 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 990317002855 active site residue [active] 990317002856 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 990317002857 CoA-disulfide reductase; Region: CoA_CoA_reduc; TIGR03385 990317002858 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 990317002859 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 990317002860 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125 990317002861 active site residue [active] 990317002862 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 990317002863 active site residue [active] 990317002864 Predicted HD superfamily hydrolase [General function prediction only]; Region: COG1418 990317002865 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 990317002866 Zn2+ binding site [ion binding]; other site 990317002867 Mg2+ binding site [ion binding]; other site 990317002868 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 990317002869 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 990317002870 Coenzyme A binding pocket [chemical binding]; other site 990317002871 Protein of unknown function (DUF2974); Region: DUF2974; pfam11187 990317002872 Transcriptional regulator [Transcription]; Region: LysR; COG0583 990317002873 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 990317002874 LysR substrate binding domain; Region: LysR_substrate; pfam03466 990317002875 dimerization interface [polypeptide binding]; other site 990317002876 Uncharacterized homolog of gamma-carboxymuconolactone decarboxylase subunit [Function unknown]; Region: COG0599 990317002877 Uncharacterized homolog of gamma-carboxymuconolactone decarboxylase subunit [Function unknown]; Region: COG0599 990317002878 short chain dehydrogenase; Provisional; Region: PRK06940 990317002879 classical (c) SDRs; Region: SDR_c; cd05233 990317002880 NAD(P) binding site [chemical binding]; other site 990317002881 active site 990317002882 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 990317002883 NADH(P)-binding; Region: NAD_binding_10; pfam13460 990317002884 NAD(P) binding site [chemical binding]; other site 990317002885 active site 990317002886 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 990317002887 Helix-Turn-Helix DNA binding domain of the MerR-like transcription regulators YyaN and YraB; Region: HTH_YyaN; cd01109 990317002888 DNA binding residues [nucleotide binding] 990317002889 putative dimer interface [polypeptide binding]; other site 990317002890 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 990317002891 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 990317002892 active site 990317002893 catalytic tetrad [active] 990317002894 Uncharacterized homolog of gamma-carboxymuconolactone decarboxylase subunit [Function unknown]; Region: COG0599 990317002895 Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1917 990317002896 Flagellin N-methylase; Region: FliB; pfam03692 990317002897 HAD superfamily (subfamily IA) hydrolase, TIGR02254; Region: YjjG/YfnB 990317002898 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 990317002899 motif II; other site 990317002900 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 990317002901 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 990317002902 ligand binding site [chemical binding]; other site 990317002903 flexible hinge region; other site 990317002904 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 990317002905 non-specific DNA interactions [nucleotide binding]; other site 990317002906 DNA binding site [nucleotide binding] 990317002907 sequence specific DNA binding site [nucleotide binding]; other site 990317002908 putative cAMP binding site [chemical binding]; other site 990317002909 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 990317002910 LysR transcriptional regulator; Provisional; Region: rbcR; CHL00180 990317002911 C-terminal substrate binding domain of LysR-type transcriptional regulator CysL, which activates the transcription of the cysJI operon encoding sulfite reductase, contains the type 2 periplasmic binding fold; Region: PBP2_CysL_like; cd08420 990317002912 putative dimerization interface [polypeptide binding]; other site 990317002913 Predicted membrane protein [Function unknown]; Region: COG2855 990317002914 NAD-dependent aldehyde dehydrogenases [Energy production and conversion]; Region: PutA; COG1012 990317002915 Mycobacterium tuberculosis succinate-semialdehyde dehydrogenase 1-like; Region: ALDH_SSADH1_GabD1; cd07100 990317002916 NAD(P) binding site [chemical binding]; other site 990317002917 catalytic residues [active] 990317002918 Bacterial low temperature requirement A protein (LtrA); Region: LtrA; cl01754 990317002919 excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558 990317002920 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 990317002921 GIY-YIG motif/motif A; other site 990317002922 active site 990317002923 catalytic site [active] 990317002924 putative DNA binding site [nucleotide binding]; other site 990317002925 metal binding site [ion binding]; metal-binding site 990317002926 UvrB/uvrC motif; Region: UVR; pfam02151 990317002927 UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459 990317002928 Uncharacterized conserved protein [Function unknown]; Region: COG3603 990317002929 Family description; Region: ACT_7; pfam13840 990317002930 Nitroreductase-like family 1. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_1; cd02137 990317002931 dimer interface [polypeptide binding]; other site 990317002932 FMN binding site [chemical binding]; other site 990317002933 dipeptidase PepV; Reviewed; Region: PRK07318 990317002934 M20 Peptidase Xaa-His dipeptidase (PepV) degrades hydrophobic dipeptides; Region: M20_PepV; cd03888 990317002935 active site 990317002936 metal binding site [ion binding]; metal-binding site 990317002937 Uncharacterized subfamily of Uracil-DNA glycosylases; Region: UDG_like_1; cd10033 990317002938 putative uracil binding site [chemical binding]; other site 990317002939 putative active site [active] 990317002940 potential frameshift: common BLAST hit: gi|288905134|ref|YP_003430356.1| tannase (serine rich protein) 990317002941 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 990317002942 Cyclic nucleotide-binding domain; Region: cNMP_binding; pfam00027 990317002943 ligand binding site [chemical binding]; other site 990317002944 flexible hinge region; other site 990317002945 Crp-like helix-turn-helix domain; Region: HTH_Crp_2; pfam13545 990317002946 tRNA modification GTPase TrmE; Reviewed; Region: trmE; PRK05291 990317002947 GTP-binding protein TrmE N-terminus; Region: TrmE_N; pfam10396 990317002948 trmE is a tRNA modification GTPase; Region: trmE; cd04164 990317002949 G1 box; other site 990317002950 GTP/Mg2+ binding site [chemical binding]; other site 990317002951 Switch I region; other site 990317002952 G2 box; other site 990317002953 Switch II region; other site 990317002954 G3 box; other site 990317002955 G4 box; other site 990317002956 G5 box; other site 990317002957 Catalytic cysteine-containing C-terminus of GTPase, MnmE; Region: GTPase_Cys_C; pfam12631 990317002958 RPI_A: Ribose 5-phosphate isomerase type A (RPI_A) subfamily; RPI catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate, the first step of the non-oxidative branch of the pentose phosphate pathway. This reaction leads to the...; Region: RPI_A; cd01398 990317002959 tetramer (dimer of dimers) interface [polypeptide binding]; other site 990317002960 active site 990317002961 dimer interface [polypeptide binding]; other site 990317002962 phosphopentomutase; Provisional; Region: PRK05362 990317002963 Metalloenzyme superfamily; Region: Metalloenzyme; pfam01676 990317002964 purine nucleoside phosphorylase; Provisional; Region: PRK08202 990317002965 GMP synthase - Glutamine amidotransferase domain [Nucleotide transport and metabolism]; Region: GuaA; COG0518 990317002966 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_1; cd01741 990317002967 catalytic triad [active] 990317002968 Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038 990317002969 Putative ClC chloride channel. Clc proteins are putative halogen ion (Cl-, Br- and I-) transporters found in eubacteria. They belong to the ClC superfamily of halogen ion channels, which share a unique double-barreled architecture and voltage-dependent...; Region: ClC_like; cd01033 990317002970 putative ion selectivity filter; other site 990317002971 putative pore gating glutamate residue; other site 990317002972 purine nucleoside phosphorylase; Reviewed; Region: deoD; PRK05819 990317002973 Uridine phosphorylase [Nucleotide transport and metabolism]; Region: Udp; COG2820 990317002974 CRISPR/Cas system-associated protein Csm6; Region: Csm6_III-A; cl09873 990317002975 Transcriptional regulator [Transcription]; Region: LysR; COG0583 990317002976 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 990317002977 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 990317002978 dimerization interface [polypeptide binding]; other site 990317002979 DNA polymerase processivity factor; Region: DNA_PPF; pfam02916 990317002980 Cell envelope-related transcriptional attenuator domain; Region: LytR_cpsA_psr; pfam03816 990317002981 Capsular polysaccharide biosynthesis protein [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: CapC; COG4464 990317002982 polysaccharide export protein, MPA1 family, Gram-positive type; Region: polys_exp_MPA1; TIGR01006 990317002983 Capsular polysaccharide biosynthesis protein [Cell envelope biogenesis, outer membrane]; Region: COG3944 990317002984 capsular exopolysaccharide family; Region: eps_fam; TIGR01007 990317002985 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 990317002986 exopolysaccharide biosynthesis polyprenyl glycosylphosphotransferase; Region: EPS_sugtrans; TIGR03025 990317002987 Bacterial sugar transferase; Region: Bac_transf; pfam02397 990317002988 This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_6; cd04955 990317002989 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 990317002990 putative glycosyl transferase; Provisional; Region: PRK10073 990317002991 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 990317002992 active site 990317002993 Protein of unknown function (DUF563); Region: DUF563; pfam04577 990317002994 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 990317002995 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 990317002996 Putative glycosyl/glycerophosphate transferases involved in teichoic acid biosynthesis TagF/TagB/EpsJ/RodC [Cell envelope biogenesis, outer membrane]; Region: TagB; COG1887 990317002997 CDP-Glycerol:Poly(glycerophosphate) glycerophosphotransferase; Region: Glyphos_transf; pfam04464 990317002998 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 990317002999 NAD(P) binding site [chemical binding]; other site 990317003000 active site 990317003001 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 990317003002 Cytidylyltransferase; Region: CTP_transf_2; pfam01467 990317003003 active site 990317003004 nucleotide binding site [chemical binding]; other site 990317003005 HIGH motif; other site 990317003006 KMSKS motif; other site 990317003007 Transcriptional antiterminator [Transcription]; Region: BglG; COG3711 990317003008 HTH domain; Region: HTH_11; pfam08279 990317003009 PRD domain; Region: PRD; pfam00874 990317003010 PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568 990317003011 active site 990317003012 P-loop; other site 990317003013 phosphorylation site [posttranslational modification] 990317003014 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cl00163 990317003015 active site 990317003016 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 990317003017 active site 990317003018 phosphorylation site [posttranslational modification] 990317003019 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569 990317003020 active site 990317003021 P-loop; other site 990317003022 phosphorylation site [posttranslational modification] 990317003023 Phosphotransferase system, fructose-specific IIC component [Carbohydrate transport and metabolism]; Region: FruA; COG1299 990317003024 alpha-mannosidase; Provisional; Region: PRK09819 990317003025 N-terminal catalytic domain of Escherichia coli alpha-mannosidase MngB and its bacterial homologs; glycoside hydrolase family 38 (GH38); Region: GH38N_AMII_EcMngB_like; cd10815 990317003026 active site 990317003027 metal binding site [ion binding]; metal-binding site 990317003028 catalytic site [active] 990317003029 Alpha mannosidase, middle domain; Region: Alpha-mann_mid; smart00872 990317003030 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 990317003031 Helix-turn-helix domain; Region: HTH_38; pfam13936 990317003032 HTH-like domain; Region: HTH_21; pfam13276 990317003033 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 990317003034 Integrase core domain; Region: rve; pfam00665 990317003035 Integrase core domain; Region: rve_2; pfam13333 990317003036 dihydroorotate dehydrogenase electron transfer subunit; Reviewed; Region: PRK00054 990317003037 FAD/NAD binding domain in the electron transfer subunit of dihydroorotate dehydrogenase. Dihydroorotate dehydrogenases (DHODs) catalyze the only redox reaction in pyrimidine de novo biosynthesis. They catalyze the oxidation of (S)-dihydroorotate to...; Region: DHOD_e_trans; cd06218 990317003038 FAD binding pocket [chemical binding]; other site 990317003039 FAD binding motif [chemical binding]; other site 990317003040 phosphate binding motif [ion binding]; other site 990317003041 beta-alpha-beta structure motif; other site 990317003042 NAD binding pocket [chemical binding]; other site 990317003043 Iron coordination center [ion binding]; other site 990317003044 dihydroorotate dehydrogenase (subfamily 1) family protein; Region: pyrD_sub1_fam; TIGR01037 990317003045 Dihydroorotate dehydrogenase (DHOD) class 1B FMN-binding domain. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine...; Region: DHOD_1B_like; cd04740 990317003046 heterodimer interface [polypeptide binding]; other site 990317003047 active site 990317003048 FMN binding site [chemical binding]; other site 990317003049 homodimer interface [polypeptide binding]; other site 990317003050 substrate binding site [chemical binding]; other site 990317003051 Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725 990317003052 active site 990317003053 dimer interface [polypeptide binding]; other site 990317003054 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 990317003055 active site 990317003056 PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in bacteria and archaea; Region: PEBP_bact_arch; cd00865 990317003057 substrate binding site [chemical binding]; other site 990317003058 Family 1 of Uracil-DNA glycosylase (UDG) enzymes; Region: UDG_F1; cd10027 990317003059 ligand binding site [chemical binding]; other site 990317003060 active site 990317003061 UGI interface [polypeptide binding]; other site 990317003062 catalytic site [active] 990317003063 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 990317003064 conserved cys residue [active] 990317003065 dihydroorotase; Validated; Region: pyrC; PRK09357 990317003066 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 990317003067 Dihydroorotase (DHOase), subgroup IIa; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This subgroup also contains proteins that lack the active site, like unc-33, a C; Region: DHOase_IIa; cd01317 990317003068 active site 990317003069 putative glycerol-3-phosphate acyltransferase PlsY; Provisional; Region: PRK00220 990317003070 DNA topoisomerase IV, B subunit, Gram-positive; Region: parE_Gpos; TIGR01058 990317003071 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 990317003072 Mg2+ binding site [ion binding]; other site 990317003073 G-X-G motif; other site 990317003074 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 990317003075 anchoring element; other site 990317003076 dimer interface [polypeptide binding]; other site 990317003077 ATP binding site [chemical binding]; other site 990317003078 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 990317003079 active site 990317003080 putative metal-binding site [ion binding]; other site 990317003081 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 990317003082 DNA topoisomerase IV, A subunit, Gram-positive; Region: parC_Gpos; TIGR01061 990317003083 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 990317003084 CAP-like domain; other site 990317003085 active site 990317003086 primary dimer interface [polypeptide binding]; other site 990317003087 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 990317003088 branched-chain amino acid aminotransferase; Provisional; Region: PRK13357 990317003089 BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557 990317003090 homodimer interface [polypeptide binding]; other site 990317003091 substrate-cofactor binding pocket; other site 990317003092 catalytic residue [active] 990317003093 Protein of unknown function (DUF2969); Region: DUF2969; pfam11184 990317003094 30S ribosomal protein S1; Reviewed; Region: rpsA; PRK06676 990317003095 S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687 990317003096 RNA binding site [nucleotide binding]; other site 990317003097 S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465 990317003098 RNA binding site [nucleotide binding]; other site 990317003099 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 990317003100 RNA binding site [nucleotide binding]; other site 990317003101 S1_RPS1_repeat_hs4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_hs4; cd05692 990317003102 RNA binding site [nucleotide binding]; other site 990317003103 LrgB-like family; Region: LrgB; pfam04172 990317003104 Putative effector of murein hydrolase LrgA [General function prediction only]; Region: COG1380 990317003105 Uncharacterized conserved protein [Function unknown]; Region: COG0398 990317003106 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 990317003107 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 990317003108 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 990317003109 Walker A/P-loop; other site 990317003110 ATP binding site [chemical binding]; other site 990317003111 Q-loop/lid; other site 990317003112 ABC transporter signature motif; other site 990317003113 Walker B; other site 990317003114 D-loop; other site 990317003115 H-loop/switch region; other site 990317003116 Predicted transcriptional regulators [Transcription]; Region: COG1725 990317003117 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 990317003118 DNA-binding site [nucleotide binding]; DNA binding site 990317003119 DNA polymerase III DnaE; Reviewed; Region: dnaE; PRK07279 990317003120 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III; Region: PHP_PolIIIA; cd07431 990317003121 active site 990317003122 PHP Thumb interface [polypeptide binding]; other site 990317003123 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 990317003124 generic binding surface II; other site 990317003125 generic binding surface I; other site 990317003126 6-phosphofructokinase; Provisional; Region: PRK03202 990317003127 6-phosphofructokinase; Region: PFKA_ATP; TIGR02482 990317003128 active site 990317003129 ADP/pyrophosphate binding site [chemical binding]; other site 990317003130 dimerization interface [polypeptide binding]; other site 990317003131 allosteric effector site; other site 990317003132 fructose-1,6-bisphosphate binding site; other site 990317003133 pyruvate kinase; Provisional; Region: PRK05826 990317003134 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342 990317003135 domain interfaces; other site 990317003136 active site 990317003137 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 990317003138 The S24, S26 LexA/signal peptidase superfamily contains LexA-related and type I signal peptidase families. The S24 LexA protein domains include: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC 3.4.21.88), the...; Region: Peptidase_S24_S26; cl10465 990317003139 Catalytic site [active] 990317003140 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 990317003141 glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331 990317003142 Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans). The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714 990317003143 glutaminase active site [active] 990317003144 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 990317003145 dimer interface [polypeptide binding]; other site 990317003146 active site 990317003147 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 990317003148 dimer interface [polypeptide binding]; other site 990317003149 active site 990317003150 Phosphotransferase system, mannitol-specific IIBC component [Carbohydrate transport and metabolism]; Region: MtlA; COG2213 990317003151 PTS system, mannitol-specific IIC component; Region: mtlA; TIGR00851 990317003152 PTS_IIB_mannitol: subunit IIB of enzyme II (EII) of the mannitol-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is a mannitol-specific permease with two cytoplasmic domains (IIA and IIB) and a transmembrane...; Region: PTS_IIB_mannitol; cd05567 990317003153 active site 990317003154 P-loop; other site 990317003155 phosphorylation site [posttranslational modification] 990317003156 PTS_IIB_mannitol: subunit IIB of enzyme II (EII) of the mannitol-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is a mannitol-specific permease with two cytoplasmic domains (IIA and IIB) and a transmembrane...; Region: PTS_IIB_mannitol; cd05567 990317003157 active site 990317003158 P-loop; other site 990317003159 phosphorylation site [posttranslational modification] 990317003160 Transcriptional antiterminator [Transcription]; Region: BglG; COG3711 990317003161 HTH domain; Region: HTH_11; pfam08279 990317003162 HTH domain; Region: HTH_11; pfam08279 990317003163 PTS_IIB: subunit IIB of enzyme II (EII) is the central energy-coupling domain of the phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In the multienzyme PTS complex, EII is a carbohydrate-specific permease consisting of two cytoplasmic...; Region: PTS_IIB; cl10014 990317003164 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cl00163 990317003165 active site 990317003166 phosphorylation site [posttranslational modification] 990317003167 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 990317003168 active site 990317003169 phosphorylation site [posttranslational modification] 990317003170 mannitol-1-phosphate 5-dehydrogenase; Provisional; Region: PRK02318 990317003171 Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232 990317003172 Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125 990317003173 Uncharacterized Zn-ribbon-containing protein involved in phosphonate metabolism [Inorganic ion transport and metabolism]; Region: PhnA; COG2824 990317003174 PhnA Zinc-Ribbon; Region: PhnA_Zn_Ribbon; pfam08274 990317003175 PhnA protein; Region: PhnA; pfam03831 990317003176 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 990317003177 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 990317003178 dimer interface [polypeptide binding]; other site 990317003179 conserved gate region; other site 990317003180 ABC-ATPase subunit interface; other site 990317003181 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 990317003182 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 990317003183 Walker A/P-loop; other site 990317003184 ATP binding site [chemical binding]; other site 990317003185 Q-loop/lid; other site 990317003186 ABC transporter signature motif; other site 990317003187 Walker B; other site 990317003188 D-loop; other site 990317003189 H-loop/switch region; other site 990317003190 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 990317003191 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 990317003192 substrate binding pocket [chemical binding]; other site 990317003193 membrane-bound complex binding site; other site 990317003194 hinge residues; other site 990317003195 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 990317003196 cation diffusion facilitator family transporter; Region: CDF; TIGR01297 990317003197 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4994 990317003198 Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115 990317003199 Sodium:alanine symporter family; Region: Na_Ala_symp; cl00548 990317003200 Glycosyl hydrolase family 1; Region: Glyco_hydro_1; cl01046 990317003201 beta-galactosidase; Region: BGL; TIGR03356 990317003202 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 990317003203 catalytic core [active] 990317003204 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 990317003205 catalytic core [active] 990317003206 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 990317003207 catalytic core [active] 990317003208 Domain of unknown function DUF20; Region: UPF0118; pfam01594 990317003209 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 990317003210 A4GalT_like proteins catalyze the addition of galactose or glucose residues to the lipooligosaccharide (LOS) or lipopolysaccharide (LPS) of the bacterial cell surface; Region: GT8_A4GalT_like; cd04194 990317003211 Glycosyl transferase family 8; Region: Glyco_transf_8; pfam01501 990317003212 Ligand binding site; other site 990317003213 metal-binding site 990317003214 hypothetical protein; Reviewed; Region: PRK00024 990317003215 Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071 990317003216 MPN+ (JAMM) motif; other site 990317003217 Zinc-binding site [ion binding]; other site 990317003218 redox-sensing transcriptional repressor Rex; Provisional; Region: PRK05472 990317003219 Putative DNA-binding protein N-terminus; Region: Put_DNA-bind_N; pfam06971 990317003220 CoA binding domain; Region: CoA_binding; pfam02629 990317003221 Putative amino acid metabolism; Region: DUF1831; pfam08866 990317003222 Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104 990317003223 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 990317003224 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 990317003225 catalytic residue [active] 990317003226 ribose-phosphate pyrophosphokinase; Provisional; Region: PRK02458 990317003227 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 990317003228 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 990317003229 active site 990317003230 Uncharacterized subgroup 1 of the CYTH-like superfamily; Region: CYTH-like_Pase_1; cd07762 990317003231 putative active site [active] 990317003232 putative metal binding residues [ion binding]; other site 990317003233 signature motif; other site 990317003234 putative triphosphate binding site [ion binding]; other site 990317003235 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 990317003236 synthetase active site [active] 990317003237 NTP binding site [chemical binding]; other site 990317003238 metal binding site [ion binding]; metal-binding site 990317003239 inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK04885 990317003240 ATP-NAD kinase; Region: NAD_kinase; pfam01513 990317003241 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 990317003242 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 990317003243 active site 990317003244 phosphotransacetylase; Reviewed; Region: eutD; PRK09653 990317003245 classical (c) SDR, subgroup 5; Region: SDR_c5; cd05346 990317003246 malonic semialdehyde reductase; Provisional; Region: PRK10538 990317003247 putative NAD(P) binding site [chemical binding]; other site 990317003248 homodimer interface [polypeptide binding]; other site 990317003249 homotetramer interface [polypeptide binding]; other site 990317003250 active site 990317003251 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 990317003252 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 990317003253 active site 990317003254 motif I; other site 990317003255 motif II; other site 990317003256 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 990317003257 Beta-glucosidase/6-phospho-beta-glucosidase/beta- galactosidase [Carbohydrate transport and metabolism]; Region: BglB; COG2723 990317003258 beta-galactosidase; Region: BGL; TIGR03356 990317003259 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 990317003260 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 990317003261 Walker A/P-loop; other site 990317003262 ATP binding site [chemical binding]; other site 990317003263 Q-loop/lid; other site 990317003264 ABC transporter signature motif; other site 990317003265 Walker B; other site 990317003266 D-loop; other site 990317003267 H-loop/switch region; other site 990317003268 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 990317003269 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 990317003270 FtsX-like permease family; Region: FtsX; pfam02687 990317003271 guanosine 5'-monophosphate oxidoreductase; Provisional; Region: PRK05458 990317003272 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 990317003273 active site 990317003274 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 990317003275 Predicted transcriptional regulator [Transcription]; Region: COG2378 990317003276 HTH domain; Region: HTH_11; pfam08279 990317003277 WYL domain; Region: WYL; pfam13280 990317003278 Protein of unknown function (DUF1211); Region: DUF1211; cl01421 990317003279 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 990317003280 active site 990317003281 xanthine permease; Region: pbuX; TIGR03173 990317003282 Sulfate transporter family; Region: Sulfate_transp; pfam00916 990317003283 Membrane-associated lipoprotein involved in thiamine biosynthesis [Coenzyme metabolism]; Region: ApbE; COG1477 990317003284 ApbE family; Region: ApbE; pfam02424 990317003285 4-oxalocrotonate tautomerase; Provisional; Region: PRK02289 990317003286 active site 1 [active] 990317003287 dimer interface [polypeptide binding]; other site 990317003288 hexamer interface [polypeptide binding]; other site 990317003289 active site 2 [active] 990317003290 thymidine kinase; Provisional; Region: PRK04296 990317003291 peptide chain release factor 1; Validated; Region: prfA; PRK00591 990317003292 This domain is found in peptide chain release factors; Region: PCRF; smart00937 990317003293 RF-1 domain; Region: RF-1; pfam00472 990317003294 N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328 990317003295 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 990317003296 S-adenosylmethionine binding site [chemical binding]; other site 990317003297 Putative translation factor (SUA5) [Translation, ribosomal structure and biogenesis]; Region: SUA5; COG0009 990317003298 serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011 990317003299 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378 990317003300 dimer interface [polypeptide binding]; other site 990317003301 active site 990317003302 glycine-pyridoxal phosphate binding site [chemical binding]; other site 990317003303 folate binding site [chemical binding]; other site 990317003304 37-kD nucleoid-associated bacterial protein; Region: NA37; cl15473 990317003305 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 990317003306 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 990317003307 N-acetyl-D-glucosamine binding site [chemical binding]; other site 990317003308 catalytic residue [active] 990317003309 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 990317003310 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 990317003311 ATP-binding cassette domain of multidrug resistance protein-like transporters; Region: ABCC_MRP_Like; cd03228 990317003312 Walker A/P-loop; other site 990317003313 ATP binding site [chemical binding]; other site 990317003314 Q-loop/lid; other site 990317003315 ABC transporter signature motif; other site 990317003316 Walker B; other site 990317003317 D-loop; other site 990317003318 H-loop/switch region; other site 990317003319 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 990317003320 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 990317003321 ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254 990317003322 Walker A/P-loop; other site 990317003323 ATP binding site [chemical binding]; other site 990317003324 Q-loop/lid; other site 990317003325 ABC transporter signature motif; other site 990317003326 Walker B; other site 990317003327 D-loop; other site 990317003328 H-loop/switch region; other site 990317003329 cytoplasmic alpha-amylase; Reviewed; Region: PRK09441 990317003330 Alpha amylase catalytic domain found in bacterial and fungal Alpha amylases (also called 1,4-alpha-D-glucan-4-glucanohydrolase); Region: AmyAc_bac_fung_AmyA; cd11318 990317003331 active site 990317003332 Na/Ca binding site [ion binding]; other site 990317003333 catalytic site [active] 990317003334 Domain of unknown function (DUF1939); Region: DUF1939; pfam09154 990317003335 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 990317003336 Uncharacterized conserved protein [Function unknown]; Region: COG0398 990317003337 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 990317003338 CAT RNA binding domain; Region: CAT_RBD; smart01061 990317003339 transcriptional antiterminator BglG; Provisional; Region: PRK09772 990317003340 PRD domain; Region: PRD; pfam00874 990317003341 PRD domain; Region: PRD; pfam00874 990317003342 PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_lac; cd00215 990317003343 methionine cluster; other site 990317003344 active site 990317003345 phosphorylation site [posttranslational modification] 990317003346 metal binding site [ion binding]; metal-binding site 990317003347 phosphotransferase system, lactose specific, IIC component; Region: lac_pts_IIC; TIGR00394 990317003348 Phosphotransferase system, EIIC; Region: PTS_EIIC; pfam02378 990317003349 PTS_IIB: subunit IIB of enzyme II (EII) is the central energy-coupling domain of the phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In the multienzyme PTS complex, EII is a carbohydrate-specific permease consisting of two cytoplasmic...; Region: PTS_IIB; cl10014 990317003350 active site 990317003351 P-loop; other site 990317003352 phosphorylation site [posttranslational modification] 990317003353 6-phospho-beta-galactosidase; Provisional; Region: PRK13511 990317003354 beta-galactosidase; Region: BGL; TIGR03356 990317003355 GMP synthase; Reviewed; Region: guaA; PRK00074 990317003356 Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742 990317003357 AMP/PPi binding site [chemical binding]; other site 990317003358 candidate oxyanion hole; other site 990317003359 catalytic triad [active] 990317003360 potential glutamine specificity residues [chemical binding]; other site 990317003361 The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997 990317003362 ATP Binding subdomain [chemical binding]; other site 990317003363 Dimerization subdomain; other site 990317003364 Type III restriction/modification enzyme methylation subunit; Region: TypeIII_RM_meth; pfam12564 990317003365 Adenine specific DNA methylase Mod [DNA replication, recombination, and repair]; Region: COG2189 990317003366 DNA methylase; Region: N6_N4_Mtase; cl17433 990317003367 DNA methylase; Region: N6_N4_Mtase; pfam01555 990317003368 DNA methylase; Region: N6_N4_Mtase; cl17433 990317003369 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 990317003370 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3421 990317003371 ATP binding site [chemical binding]; other site 990317003372 putative Mg++ binding site [ion binding]; other site 990317003373 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 990317003374 Plasmid replication protein; Region: Rep_2; pfam01719 990317003375 phiLC3 phage and phage-related integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes various bacterial (mainly gram positive) and phage integrases, including those similar to Lactococcus...; Region: INT_phiLC3_C; cd01189 990317003376 Int/Topo IB signature motif; other site 990317003377 SAM-dependent methyltransferases [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: SmtA; COG0500 990317003378 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 990317003379 S-adenosylmethionine binding site [chemical binding]; other site 990317003380 Regulators of stationary/sporulation gene expression [Transcription]; Region: AbrB; COG2002 990317003381 looped-hinge helix DNA binding domain, AbrB family; Region: lp_hng_hel_AbrB; TIGR01439 990317003382 This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784 990317003383 glycosyltransferase, MGT family; Region: MGT; TIGR01426 990317003384 homodimer interface [polypeptide binding]; other site 990317003385 active site 990317003386 TDP-binding site; other site 990317003387 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 990317003388 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 990317003389 non-specific DNA binding site [nucleotide binding]; other site 990317003390 salt bridge; other site 990317003391 sequence-specific DNA binding site [nucleotide binding]; other site 990317003392 transcriptional activator, Rgg/GadR/MutR family, C-terminal domain; Region: RGG_Cterm; TIGR01716 990317003393 Glycosyl hydrolase family 70; Region: Glyco_hydro_70; pfam02324 990317003394 Alpha amylase catalytic domain family; Region: AmyAc_family; cl07893 990317003395 glucan-binding repeat; Region: glucan_65_rpt; TIGR04035 990317003396 glucan-binding repeat; Region: glucan_65_rpt; TIGR04035 990317003397 glucan-binding repeat; Region: glucan_65_rpt; TIGR04035 990317003398 glucan-binding repeat; Region: glucan_65_rpt; TIGR04035 990317003399 glucan-binding repeat; Region: glucan_65_rpt; TIGR04035 990317003400 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 990317003401 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 990317003402 non-specific DNA binding site [nucleotide binding]; other site 990317003403 salt bridge; other site 990317003404 sequence-specific DNA binding site [nucleotide binding]; other site 990317003405 transcriptional activator, Rgg/GadR/MutR family, C-terminal domain; Region: RGG_Cterm; TIGR01716 990317003406 glucan-binding repeat; Region: glucan_65_rpt; TIGR04035 990317003407 Glycosyl hydrolase family 70; Region: Glyco_hydro_70; pfam02324 990317003408 Alpha-amylase domain; Region: Aamy; smart00642 990317003409 glucan-binding repeat; Region: glucan_65_rpt; TIGR04035 990317003410 glucan-binding repeat; Region: glucan_65_rpt; TIGR04035 990317003411 glucan-binding repeat; Region: glucan_65_rpt; TIGR04035 990317003412 glucan-binding repeat; Region: glucan_65_rpt; TIGR04035 990317003413 glucan-binding repeat; Region: glucan_65_rpt; TIGR04035 990317003414 glucan-binding repeat; Region: glucan_65_rpt; TIGR04035 990317003415 Glucan-binding protein C; Region: GbpC; pfam08363 990317003416 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 990317003417 Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; Region: MATE_like_8; cd13134 990317003418 GIY-YIG domain of uncharacterized bacterial protein structurally related to COG3410; Region: GIY-YIG_COG3410; cd10439 990317003419 GIY-YIG motif/motif A; other site 990317003420 putative active site [active] 990317003421 putative metal binding site [ion binding]; other site 990317003422 AAA domain; Region: AAA_30; pfam13604 990317003423 Uncharacterized conserved protein (DUF2075); Region: DUF2075; pfam09848 990317003424 Uncharacterized conserved protein [Function unknown]; Region: COG3410 990317003425 AAA ATPase domain; Region: AAA_15; pfam13175 990317003426 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 990317003427 Walker A/P-loop; other site 990317003428 ATP binding site [chemical binding]; other site 990317003429 TOPRIM_OLD: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in bacterial and archaeal nucleases of the OLD (overcome lysogenization defect) family. The bacteriophage P2 OLD protein, which has DNase as well as...; Region: TOPRIM_OLD; cd01026 990317003430 putative active site [active] 990317003431 putative metal-binding site [ion binding]; other site 990317003432 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 990317003433 Part of AAA domain; Region: AAA_19; pfam13245 990317003434 Family description; Region: UvrD_C_2; pfam13538 990317003435 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 990317003436 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 990317003437 DNA-binding site [nucleotide binding]; DNA binding site 990317003438 UTRA domain; Region: UTRA; pfam07702 990317003439 type VII secretion effector, SACOL2603 family; Region: T7SS_SACOL2603; TIGR04197 990317003440 LXG domain of WXG superfamily; Region: LXG; pfam04740 990317003441 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 990317003442 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 990317003443 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 990317003444 putative active site [active] 990317003445 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 990317003446 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 990317003447 Domain of unknown function (DUF336); Region: DUF336; cl01249 990317003448 putative oxidoreductase; Provisional; Region: PRK10206 990317003449 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 990317003450 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 990317003451 Antitoxin Phd_YefM, type II toxin-antitoxin system; Region: PhdYeFM_antitox; pfam02604 990317003452 Putative helix-turn-helix protein, YlxM / p13 like; Region: UPF0122; pfam04297 990317003453 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 990317003454 signal recognition particle protein; Provisional; Region: PRK10867 990317003455 SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963 990317003456 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 990317003457 P loop; other site 990317003458 GTP binding site [chemical binding]; other site 990317003459 Signal peptide binding domain; Region: SRP_SPB; pfam02978 990317003460 Helix-turn-helix domain; Region: HTH_18; pfam12833 990317003461 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 990317003462 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 990317003463 Walker A/P-loop; other site 990317003464 ATP binding site [chemical binding]; other site 990317003465 Q-loop/lid; other site 990317003466 ABC transporter signature motif; other site 990317003467 Walker B; other site 990317003468 D-loop; other site 990317003469 H-loop/switch region; other site 990317003470 Hypothetical bacterial integral membrane protein (Trep_Strep); Region: Trep_Strep; cl09823 990317003471 ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619 990317003472 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 990317003473 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 990317003474 Walker A/P-loop; other site 990317003475 ATP binding site [chemical binding]; other site 990317003476 Q-loop/lid; other site 990317003477 ABC transporter signature motif; other site 990317003478 Walker B; other site 990317003479 D-loop; other site 990317003480 H-loop/switch region; other site 990317003481 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 990317003482 cobalt transport protein ATP-binding subunit; Region: cbiO; TIGR01166 990317003483 Walker A/P-loop; other site 990317003484 ATP binding site [chemical binding]; other site 990317003485 Q-loop/lid; other site 990317003486 ABC transporter signature motif; other site 990317003487 Walker B; other site 990317003488 D-loop; other site 990317003489 H-loop/switch region; other site 990317003490 site-specific tyrosine recombinase XerS; Reviewed; Region: xerS; PRK05084 990317003491 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 990317003492 active site 990317003493 DNA binding site [nucleotide binding] 990317003494 Int/Topo IB signature motif; other site 990317003495 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 990317003496 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 990317003497 non-specific DNA binding site [nucleotide binding]; other site 990317003498 salt bridge; other site 990317003499 sequence-specific DNA binding site [nucleotide binding]; other site 990317003500 Predicted transcriptional regulator [Transcription]; Region: COG2932 990317003501 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 990317003502 Catalytic site [active] 990317003503 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 990317003504 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 990317003505 ATP binding site [chemical binding]; other site 990317003506 G-X-G motif; other site 990317003507 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 990317003508 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 990317003509 active site 990317003510 phosphorylation site [posttranslational modification] 990317003511 intermolecular recognition site; other site 990317003512 dimerization interface [polypeptide binding]; other site 990317003513 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 990317003514 DNA binding site [nucleotide binding] 990317003515 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 990317003516 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 990317003517 Walker A/P-loop; other site 990317003518 ATP binding site [chemical binding]; other site 990317003519 Q-loop/lid; other site 990317003520 ABC transporter signature motif; other site 990317003521 Walker B; other site 990317003522 D-loop; other site 990317003523 H-loop/switch region; other site 990317003524 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 990317003525 tRNA (uracil-5-)-methyltransferase Gid; Reviewed; Region: PRK05335 990317003526 Glucose inhibited division protein A; Region: GIDA; pfam01134 990317003527 Protein of unknown function (DUF3307); Region: DUF3307; pfam11750 990317003528 DNA topoisomerase I; Validated; Region: PRK05582 990317003529 TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I. Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363 990317003530 active site 990317003531 interdomain interaction site; other site 990317003532 putative metal-binding site [ion binding]; other site 990317003533 nucleotide binding site [chemical binding]; other site 990317003534 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 990317003535 domain I; other site 990317003536 DNA binding groove [nucleotide binding] 990317003537 phosphate binding site [ion binding]; other site 990317003538 domain II; other site 990317003539 domain III; other site 990317003540 nucleotide binding site [chemical binding]; other site 990317003541 catalytic site [active] 990317003542 domain IV; other site 990317003543 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 990317003544 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 990317003545 DNA recombination-mediator protein A; Region: DNA_processg_A; pfam02481 990317003546 DNA protecting protein DprA; Region: dprA; TIGR00732 990317003547 maltose O-acetyltransferase; Provisional; Region: PRK10092 990317003548 Maltose O-acetyltransferase (MAT) and Galactoside O-acetyltransferase (GAT): MAT and GAT catalyze the CoA-dependent acetylation of the 6-hydroxyl group of their respective sugar substrates. MAT acetylates maltose and glucose exclusively at the C6...; Region: LbH_MAT_GAT; cd03357 990317003549 active site 990317003550 substrate binding site [chemical binding]; other site 990317003551 trimer interface [polypeptide binding]; other site 990317003552 CoA binding site [chemical binding]; other site 990317003553 bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182 990317003554 RNA/DNA hybrid binding site [nucleotide binding]; other site 990317003555 active site 990317003556 GTPase YlqF; Reviewed; Region: rbgA; PRK09563 990317003557 Circularly permuted YlqF GTPase; Region: YlqF; cd01856 990317003558 GTP/Mg2+ binding site [chemical binding]; other site 990317003559 G4 box; other site 990317003560 G5 box; other site 990317003561 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 990317003562 G1 box; other site 990317003563 G1 box; other site 990317003564 GTP/Mg2+ binding site [chemical binding]; other site 990317003565 Switch I region; other site 990317003566 G2 box; other site 990317003567 G2 box; other site 990317003568 G3 box; other site 990317003569 G3 box; other site 990317003570 Switch II region; other site 990317003571 Switch II region; other site 990317003572 G5 box; other site 990317003573 Protein of unknown function (DUF4231); Region: DUF4231; pfam14015 990317003574 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 990317003575 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 990317003576 dimer interface [polypeptide binding]; other site 990317003577 phosphorylation site [posttranslational modification] 990317003578 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 990317003579 ATP binding site [chemical binding]; other site 990317003580 Mg2+ binding site [ion binding]; other site 990317003581 G-X-G motif; other site 990317003582 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 990317003583 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 990317003584 active site 990317003585 phosphorylation site [posttranslational modification] 990317003586 intermolecular recognition site; other site 990317003587 dimerization interface [polypeptide binding]; other site 990317003588 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 990317003589 DNA binding site [nucleotide binding] 990317003590 lantibiotic protection ABC transporter permease subunit, MutG family; Region: lanti_perm_MutG; TIGR03733 990317003591 lantibiotic protection ABC transporter permease subunit, MutE/EpiE family; Region: lanti_perm_MutE; TIGR03732 990317003592 ATP-binding cassette domain of the bacitracin-resistance transporter; Region: ABC_BcrA_bacitracin_resist; cd03268 990317003593 gallidermin-class lantibiotic protection ABC transporter, ATP-binding subunit; Region: galliderm_ABC; TIGR03740 990317003594 Walker A/P-loop; other site 990317003595 ATP binding site [chemical binding]; other site 990317003596 Q-loop/lid; other site 990317003597 ABC transporter signature motif; other site 990317003598 Walker B; other site 990317003599 D-loop; other site 990317003600 H-loop/switch region; other site 990317003601 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 990317003602 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 990317003603 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 990317003604 ABC transporter; Region: ABC_tran_2; pfam12848 990317003605 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 990317003606 Predicted membrane protein [Function unknown]; Region: COG4720 990317003607 Pyridoxal kinase plays a key role in the synthesis of the active coenzyme pyridoxal-5'-phosphate (PLP), by catalyzing the phosphorylation of the precursor vitamin B6 in the presence of Zn2+ and ATP. Mammals are unable to synthesize PLP de novo and...; Region: pyridoxal_pyridoxamine_kinase; cd01173 990317003608 dimer interface [polypeptide binding]; other site 990317003609 pyridoxal binding site [chemical binding]; other site 990317003610 ATP binding site [chemical binding]; other site 990317003611 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 990317003612 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 990317003613 DNA-binding site [nucleotide binding]; DNA binding site 990317003614 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 990317003615 pyridoxal 5'-phosphate binding site [chemical binding]; other site 990317003616 homodimer interface [polypeptide binding]; other site 990317003617 catalytic residue [active] 990317003618 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 990317003619 Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950 990317003620 dimer interface [polypeptide binding]; other site 990317003621 active site 990317003622 catalytic residue [active] 990317003623 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 990317003624 aspartate-semialdehyde dehydrogenase; Provisional; Region: PRK14874 990317003625 Phospholipase_D-nuclease N-terminal; Region: PLDc_N; pfam13396 990317003626 Phosphatidylserine/phosphatidylglycerophosphate/car diolipin synthases and related enzymes [Lipid metabolism]; Region: Cls; COG1502 990317003627 Putative catalytic domain, repeat 1, of Streptococcus mutans uncharacterized protein SMU_988 and similar proteins; Region: PLDc_SMU_988_like_1; cd09154 990317003628 putative active site [active] 990317003629 catalytic site [active] 990317003630 Putative catalytic domain, repeat 2, of Streptococcus mutans uncharacterized protein SMU_988 and similar proteins; Region: PLDc_SMU_988_like_2; cd09160 990317003631 putative active site [active] 990317003632 catalytic site [active] 990317003633 formate--tetrahydrofolate ligase; Provisional; Region: PRK13505 990317003634 Formyltetrahydrofolate synthetase (FTHFS) catalyzes the ATP-dependent activation of formate ion via its addition to the N10 position of tetrahydrofolate. FTHFS is a highly expressed key enzyme in both the Wood-Ljungdahl pathway of autotrophic CO2...; Region: FTHFS; cd00477 990317003635 Potassium binding sites [ion binding]; other site 990317003636 Cesium cation binding sites [ion binding]; other site 990317003637 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 990317003638 DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179 990317003639 Ligand binding site; other site 990317003640 Putative Catalytic site; other site 990317003641 DXD motif; other site 990317003642 GtrA-like protein; Region: GtrA; pfam04138 990317003643 Domain of unknown function (DUF4353); Region: DUF4353; pfam14262 990317003644 Predicted periplasmic protein (DUF2233); Region: DUF2233; pfam09992 990317003645 phosphopantothenate--cysteine ligase; Validated; Region: PRK06732 990317003646 phosphopantothenoylcysteine decarboxylase; Validated; Region: PRK07313 990317003647 Flavoprotein; Region: Flavoprotein; pfam02441 990317003648 Predicted membrane protein [Function unknown]; Region: COG4684 990317003649 phosphoglucomutase-2-like protein; Provisional; Region: PTZ00150 990317003650 This CD includes PGM2 (phosphoglucomutase 2) and PGM2L1 (phosphoglucomutase 2-like 1). The mammalian PGM2 is thought to be a phosphopentomutase that catalyzes the conversion of the nucleoside breakdown products, ribose-1-phosphate and...; Region: PGM2; cd05799 990317003651 active site 990317003652 substrate binding site [chemical binding]; other site 990317003653 metal binding site [ion binding]; metal-binding site 990317003654 Mn2+ and Fe2+ transporters of the NRAMP family [Inorganic ion transport and metabolism]; Region: MntH; COG1914 990317003655 Predicted secreted protein [Function unknown]; Region: COG4086 990317003656 Protein of unknown function (DUF1002); Region: DUF1002; pfam06207 990317003657 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_1; cd08352 990317003658 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 990317003659 putative metal binding site [ion binding]; other site 990317003660 Sortase A (SrtA) or subfamily-1 sortases are cysteine transpeptidases found in gram-positive bacteria that anchor surface proteins to peptidoglycans of the bacterial cell wall envelope. They do so by catalyzing a transpeptidation reaction in which the...; Region: Sortase_A_1; cd06165 990317003661 active site 990317003662 catalytic site [active] 990317003663 DNA gyrase subunit A; Validated; Region: PRK05560 990317003664 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 990317003665 CAP-like domain; other site 990317003666 active site 990317003667 primary dimer interface [polypeptide binding]; other site 990317003668 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 990317003669 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 990317003670 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 990317003671 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 990317003672 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 990317003673 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 990317003674 L-lactate dehydrogenase; Reviewed; Region: ldh; PRK00066 990317003675 L-2-hydroxyisocapronate dehydrogenases and some bacterial L-lactate dehydrogenases; Region: HicDH_like; cd05291 990317003676 tetramer (dimer of dimers) interface [polypeptide binding]; other site 990317003677 NAD binding site [chemical binding]; other site 990317003678 dimer interface [polypeptide binding]; other site 990317003679 substrate binding site [chemical binding]; other site 990317003680 coenzyme A disulfide reductase; Reviewed; Region: PRK09564 990317003681 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 990317003682 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 990317003683 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 990317003684 HTH-like domain; Region: HTH_21; pfam13276 990317003685 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 990317003686 Integrase core domain; Region: rve; pfam00665 990317003687 Integrase core domain; Region: rve_2; pfam13333 990317003688 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 990317003689 Helix-turn-helix domain; Region: HTH_38; pfam13936 990317003690 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 990317003691 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 990317003692 TM-ABC transporter signature motif; other site 990317003693 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 990317003694 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 990317003695 TM-ABC transporter signature motif; other site 990317003696 ABC-type uncharacterized transport systems, ATPase components [General function prediction only]; Region: COG3845 990317003697 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 990317003698 Walker A/P-loop; other site 990317003699 ATP binding site [chemical binding]; other site 990317003700 Q-loop/lid; other site 990317003701 ABC transporter signature motif; other site 990317003702 Walker B; other site 990317003703 D-loop; other site 990317003704 H-loop/switch region; other site 990317003705 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 990317003706 Uncharacterized ABC-type transport system, periplasmic component/surface lipoprotein [General function prediction only]; Region: Med; COG1744 990317003707 Periplasmic binding domain of basic membrane lipoprotein, PnrA, in Treponema pallidum and its homologs from other bacteria and Archaea; Region: PBP1_BmpA_PnrA_like; cd06354 990317003708 ligand binding site [chemical binding]; other site 990317003709 2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family; Region: DeoC; cd00959 990317003710 intersubunit interface [polypeptide binding]; other site 990317003711 active site 990317003712 catalytic residue [active] 990317003713 Methyltransferase domain; Region: Methyltransf_31; pfam13847 990317003714 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 990317003715 S-adenosylmethionine binding site [chemical binding]; other site 990317003716 pantothenate kinase; Provisional; Region: PRK05439 990317003717 Pantothenate kinase (PanK) catalyzes the phosphorylation of pantothenic acid to form 4'-phosphopantothenic, which is the first of five steps in coenzyme A (CoA) biosynthetic pathway. The reaction carried out by this enzyme is a key regulatory point...; Region: PanK; cd02025 990317003718 ATP-binding site [chemical binding]; other site 990317003719 CoA-binding site [chemical binding]; other site 990317003720 Mg2+-binding site [ion binding]; other site 990317003721 30S ribosomal protein S20; Reviewed; Region: rpsT; PRK00239 990317003722 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 990317003723 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 990317003724 dimer interface [polypeptide binding]; other site 990317003725 phosphorylation site [posttranslational modification] 990317003726 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 990317003727 ATP binding site [chemical binding]; other site 990317003728 Mg2+ binding site [ion binding]; other site 990317003729 G-X-G motif; other site 990317003730 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 990317003731 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 990317003732 active site 990317003733 phosphorylation site [posttranslational modification] 990317003734 intermolecular recognition site; other site 990317003735 dimerization interface [polypeptide binding]; other site 990317003736 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 990317003737 DNA binding site [nucleotide binding] 990317003738 Aminopeptidase N [Amino acid transport and metabolism]; Region: PepN; COG0308 990317003739 Peptidase M1 Aminopeptidase N family incudes tricorn interacting factor F3, Endoplasmic reticulum aminopeptidase 1 (ERAP1), Aminopeptidase Q (APQ); Region: M1_APN_2; cd09601 990317003740 Zn binding site [ion binding]; other site 990317003741 phosphate transport system regulatory protein PhoU; Region: phoU_full; TIGR02135 990317003742 PhoU domain; Region: PhoU; pfam01895 990317003743 PhoU domain; Region: PhoU; pfam01895 990317003744 phosphate transporter ATP-binding protein; Provisional; Region: PRK14239 990317003745 ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260 990317003746 Walker A/P-loop; other site 990317003747 ATP binding site [chemical binding]; other site 990317003748 Q-loop/lid; other site 990317003749 ABC transporter signature motif; other site 990317003750 Walker B; other site 990317003751 D-loop; other site 990317003752 H-loop/switch region; other site 990317003753 phosphate transporter ATP-binding protein; Provisional; Region: PRK14237 990317003754 ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260 990317003755 Walker A/P-loop; other site 990317003756 ATP binding site [chemical binding]; other site 990317003757 Q-loop/lid; other site 990317003758 ABC transporter signature motif; other site 990317003759 Walker B; other site 990317003760 D-loop; other site 990317003761 H-loop/switch region; other site 990317003762 ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstA; COG0581 990317003763 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 990317003764 dimer interface [polypeptide binding]; other site 990317003765 conserved gate region; other site 990317003766 putative PBP binding loops; other site 990317003767 ABC-ATPase subunit interface; other site 990317003768 ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstC; COG0573 990317003769 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 990317003770 dimer interface [polypeptide binding]; other site 990317003771 conserved gate region; other site 990317003772 putative PBP binding loops; other site 990317003773 ABC-ATPase subunit interface; other site 990317003774 phosphate binding protein; Region: ptsS_2; TIGR02136 990317003775 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 990317003776 rRNA (cytosine-C(5)-)-methyltransferase RsmF; Reviewed; Region: yebU; PRK11933 990317003777 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 990317003778 S-adenosylmethionine binding site [chemical binding]; other site 990317003779 pre-rRNA processing and ribosome biogenesis; Region: Nol1_Nop2_Fmu_2; pfam13636 990317003780 glutathione reductase; Validated; Region: PRK06116 990317003781 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 990317003782 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 990317003783 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 990317003784 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 990317003785 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 990317003786 catalytic residues [active] 990317003787 Uncharacterized conserved protein [Function unknown]; Region: COG1359 990317003788 Predicted divalent heavy-metal cations transporter [Inorganic ion transport and metabolism]; Region: COG0428 990317003789 ZIP Zinc transporter; Region: Zip; pfam02535 990317003790 Methyladenine glycosylase; Region: Adenine_glyco; pfam03352 990317003791 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 990317003792 Inositol-monophosphatase-like domains. This family of phosphatases is dependent on bivalent metal ions such as Mg++, and many members are inhibited by Li+ (which is thought to displace a bivalent ion in the active site). Substrates include fructose-1; Region: IMPase_like; cd01637 990317003793 active site 990317003794 hypothetical protein; Provisional; Region: PRK04387 990317003795 Arsenate Reductase (ArsC) family, Spx subfamily; Spx is a unique RNA polymerase (RNAP)-binding protein present in bacilli and some mollicutes. It inhibits transcription by binding to the C-terminal domain of the alpha subunit of RNAP, disrupting complex...; Region: ArsC_Spx; cd03032 990317003796 ArsC family; Region: ArsC; pfam03960 990317003797 putative catalytic residues [active] 990317003798 thiol/disulfide switch; other site 990317003799 bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627 990317003800 FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064 990317003801 active site 990317003802 Riboflavin kinase; Region: Flavokinase; pfam01687 990317003803 tRNA pseudouridine synthase B; Provisional; Region: truB; PRK02484 990317003804 Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573 990317003805 RNA binding site [nucleotide binding]; other site 990317003806 active site 990317003807 tRNA Pseudouridine synthase II, C terminal; Region: TruB_C; pfam09142 990317003808 Uncharacterized conserved protein [Function unknown]; Region: COG2461 990317003809 Family of unknown function (DUF438); Region: DUF438; pfam04282 990317003810 Domain of unknown function (DUF1858); Region: DUF1858; pfam08984 990317003811 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 990317003812 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 990317003813 Coenzyme A binding pocket [chemical binding]; other site 990317003814 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4487 990317003815 Uncharacterized protein conserved in bacteria (DUF2130); Region: DUF2130; pfam09903 990317003816 HTH-like domain; Region: HTH_21; pfam13276 990317003817 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 990317003818 Integrase core domain; Region: rve; pfam00665 990317003819 Integrase core domain; Region: rve_2; pfam13333 990317003820 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 990317003821 Helix-turn-helix domain; Region: HTH_38; pfam13936 990317003822 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 990317003823 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 990317003824 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 990317003825 Walker A/P-loop; other site 990317003826 ATP binding site [chemical binding]; other site 990317003827 Q-loop/lid; other site 990317003828 ABC transporter signature motif; other site 990317003829 Walker B; other site 990317003830 D-loop; other site 990317003831 H-loop/switch region; other site 990317003832 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 990317003833 cobalt transport protein ATP-binding subunit; Region: cbiO; TIGR01166 990317003834 Walker A/P-loop; other site 990317003835 ATP binding site [chemical binding]; other site 990317003836 Q-loop/lid; other site 990317003837 ABC transporter signature motif; other site 990317003838 Walker B; other site 990317003839 D-loop; other site 990317003840 H-loop/switch region; other site 990317003841 ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619 990317003842 Hypothetical bacterial integral membrane protein (Trep_Strep); Region: Trep_Strep; pfam09605 990317003843 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 990317003844 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 990317003845 ATP-binding cassette domain of multidrug resistance protein-like transporters; Region: ABCC_MRP_Like; cd03228 990317003846 Walker A/P-loop; other site 990317003847 ATP binding site [chemical binding]; other site 990317003848 Q-loop/lid; other site 990317003849 ABC transporter signature motif; other site 990317003850 Walker B; other site 990317003851 D-loop; other site 990317003852 H-loop/switch region; other site 990317003853 ABC-type transport system involved in cytochrome bd biosynthesis, ATPase and permease components [Energy production and conversion / Posttranslational modification, protein turnover, chaperones]; Region: CydD; COG4988 990317003854 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 990317003855 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 990317003856 Walker A/P-loop; other site 990317003857 ATP binding site [chemical binding]; other site 990317003858 Q-loop/lid; other site 990317003859 ABC transporter signature motif; other site 990317003860 Walker B; other site 990317003861 D-loop; other site 990317003862 H-loop/switch region; other site 990317003863 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 990317003864 FtsX-like permease family; Region: FtsX; pfam02687 990317003865 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 990317003866 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 990317003867 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 990317003868 Walker A/P-loop; other site 990317003869 ATP binding site [chemical binding]; other site 990317003870 Q-loop/lid; other site 990317003871 ABC transporter signature motif; other site 990317003872 Walker B; other site 990317003873 D-loop; other site 990317003874 H-loop/switch region; other site 990317003875 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 990317003876 Peroxiredoxin (PRX) family, Atypical 2-cys PRX subfamily; composed of PRXs containing peroxidatic and resolving cysteines, similar to the homodimeric thiol specific antioxidant (TSA) protein also known as TRX-dependent thiol peroxidase (Tpx). Tpx is a...; Region: PRX_Atyp2cys; cd03014 990317003877 dimer interface [polypeptide binding]; other site 990317003878 catalytic triad [active] 990317003879 peroxidatic and resolving cysteines [active] 990317003880 Kynurenine formamidase [Amino acid transport and metabolism]; Region: COG1878 990317003881 O-acetylhomoserine sulfhydrylase [Amino acid transport and metabolism]; Region: MET17; COG2873 990317003882 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 990317003883 homodimer interface [polypeptide binding]; other site 990317003884 substrate-cofactor binding pocket; other site 990317003885 pyridoxal 5'-phosphate binding site [chemical binding]; other site 990317003886 catalytic residue [active] 990317003887 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 990317003888 thiamine phosphate binding site [chemical binding]; other site 990317003889 active site 990317003890 pyrophosphate binding site [ion binding]; other site 990317003891 4-methyl-5-beta-hydroxyethylthiazole (Thz) kinase catalyzes the phosphorylation of the hydroxylgroup of Thz. A reaction that allows cells to recycle Thz into the thiamine biosynthesis pathway, as an alternative to its synthesis from cysteine, tyrosine...; Region: THZ_kinase; cd01170 990317003892 substrate binding site [chemical binding]; other site 990317003893 multimerization interface [polypeptide binding]; other site 990317003894 ATP binding site [chemical binding]; other site 990317003895 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 990317003896 dimer interface [polypeptide binding]; other site 990317003897 substrate binding site [chemical binding]; other site 990317003898 ATP binding site [chemical binding]; other site 990317003899 TENA/THI-4/PQQC family; Region: TENA_THI-4; cl15243 990317003900 Predicted hydrolase (HAD superfamily) [General function prediction only]; Region: COG1011 990317003901 ?-D-glucose-1-phosphatase; Provisional; Region: PRK09456 990317003902 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 990317003903 S-adenosylmethionine binding site [chemical binding]; other site 990317003904 Thiamine-precursor transporter protein (ThiW); Region: ThiW; pfam09512 990317003905 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 990317003906 non-specific DNA binding site [nucleotide binding]; other site 990317003907 salt bridge; other site 990317003908 sequence-specific DNA binding site [nucleotide binding]; other site 990317003909 transcriptional activator, Rgg/GadR/MutR family, C-terminal domain; Region: RGG_Cterm; TIGR01716 990317003910 ATP-dependent DNA helicase PcrA; Region: pcrA; TIGR01073 990317003911 Part of AAA domain; Region: AAA_19; pfam13245 990317003912 Family description; Region: UvrD_C_2; pfam13538 990317003913 Glutamine Amidotransferase (GATase_I) involved in pyridoxine biosynthesis; Region: GATase1_PB; cd01749 990317003914 predicted active site [active] 990317003915 catalytic triad [active] 990317003916 pyridoxal 5'-phosphate synthase, synthase subunit Pdx1; Region: TIGR00343 990317003917 PdxS is a subunit of the pyridoxal 5'-phosphate (PLP) synthase, an important enzyme in deoxyxylulose 5-phosphate (DXP)-independent pathway for de novo biosynthesis of PLP, present in some eubacteria, in archaea, fungi, plants, plasmodia, and some...; Region: pdxS; cd04727 990317003918 active site 990317003919 multimer interface [polypeptide binding]; other site 990317003920 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 990317003921 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 990317003922 DNA-binding site [nucleotide binding]; DNA binding site 990317003923 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 990317003924 pyridoxal 5'-phosphate binding site [chemical binding]; other site 990317003925 homodimer interface [polypeptide binding]; other site 990317003926 catalytic residue [active] 990317003927 Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115 990317003928 amino acid carrier protein; Region: agcS; TIGR00835 990317003929 Rrf2 family protein; Region: rrf2_super; TIGR00738 990317003930 Transcriptional regulator; Region: Rrf2; pfam02082 990317003931 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 990317003932 NADH(P)-binding; Region: NAD_binding_10; pfam13460 990317003933 NAD(P) binding site [chemical binding]; other site 990317003934 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 990317003935 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cl17915 990317003936 GBS Bsp-like repeat; Region: GBS_Bsp-like; pfam08481 990317003937 GBS Bsp-like repeat; Region: GBS_Bsp-like; pfam08481 990317003938 GBS Bsp-like repeat; Region: GBS_Bsp-like; pfam08481 990317003939 GBS Bsp-like repeat; Region: GBS_Bsp-like; pfam08481 990317003940 GBS Bsp-like repeat; Region: GBS_Bsp-like; pfam08481 990317003941 GBS Bsp-like repeat; Region: GBS_Bsp-like; pfam08481 990317003942 Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various bacteriocins (mostly non-lantibiotic); Region: Peptidase_C39_like; cl00296 990317003943 putative active site [active] 990317003944 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 990317003945 SnoaL-like domain; Region: SnoaL_4; pfam13577 990317003946 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 990317003947 Major Facilitator Superfamily; Region: MFS_1; pfam07690 990317003948 putative substrate translocation pore; other site 990317003949 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 990317003950 Glycosyl hydrolase family 1; Region: Glyco_hydro_1; cl01046 990317003951 beta-galactosidase; Region: BGL; TIGR03356 990317003952 NnaC (CMP-NeuNAc synthetase) _like subfamily of SGNH_hydrolases, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its...; Region: NnaC_like; cd01841 990317003953 active site 990317003954 catalytic triad [active] 990317003955 oxyanion hole [active] 990317003956 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 990317003957 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 990317003958 active site 990317003959 motif I; other site 990317003960 motif II; other site 990317003961 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 990317003962 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cl17915 990317003963 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 990317003964 active site 990317003965 motif I; other site 990317003966 motif II; other site 990317003967 Ras GTPase Activating Domain; Region: RasGAP; cl02569 990317003968 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 990317003969 maltose O-acetyltransferase; Provisional; Region: PRK10092 990317003970 Maltose O-acetyltransferase (MAT) and Galactoside O-acetyltransferase (GAT): MAT and GAT catalyze the CoA-dependent acetylation of the 6-hydroxyl group of their respective sugar substrates. MAT acetylates maltose and glucose exclusively at the C6...; Region: LbH_MAT_GAT; cd03357 990317003971 active site 990317003972 substrate binding site [chemical binding]; other site 990317003973 trimer interface [polypeptide binding]; other site 990317003974 CoA binding site [chemical binding]; other site 990317003975 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 990317003976 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 990317003977 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 990317003978 short chain dehydrogenase; Provisional; Region: PRK06180 990317003979 17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374 990317003980 NADP binding site [chemical binding]; other site 990317003981 active site 990317003982 steroid binding site; other site 990317003983 Uncharacterized conserved protein [Function unknown]; Region: COG3589 990317003984 Bacterial protein of unknown function (DUF871); Region: DUF871; pfam05913 990317003985 cellobiose phosphotransferase system IIC component; Reviewed; Region: celD; PRK09592 990317003986 Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455 990317003987 PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_lac; cd00215 990317003988 methionine cluster; other site 990317003989 active site 990317003990 phosphorylation site [posttranslational modification] 990317003991 metal binding site [ion binding]; metal-binding site 990317003992 Transcriptional antiterminator [Transcription]; Region: BglG; COG3711 990317003993 HTH domain; Region: HTH_11; pfam08279 990317003994 Mga helix-turn-helix domain; Region: Mga; pfam05043 990317003995 PRD domain; Region: PRD; pfam00874 990317003996 PRD domain; Region: PRD; pfam00874 990317003997 PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568 990317003998 active site 990317003999 P-loop; other site 990317004000 phosphorylation site [posttranslational modification] 990317004001 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 990317004002 active site 990317004003 phosphorylation site [posttranslational modification] 990317004004 cellobiose phosphotransferase system IIB component; Reviewed; Region: celB; PRK09590 990317004005 active site 990317004006 P-loop; other site 990317004007 phosphorylation site [posttranslational modification] 990317004008 Protein of unknown function (DUF669); Region: DUF669; pfam05037 990317004009 Uncharacterized conserved protein [Function unknown]; Region: COG4095 990317004010 6-phospho-beta-glucosidase; Reviewed; Region: celA; PRK09589 990317004011 beta-galactosidase; Region: BGL; TIGR03356 990317004012 Predicted unusual protein kinase [General function prediction only]; Region: AarF; COG0661 990317004013 ABC1 family; Region: ABC1; cl17513 990317004014 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120 990317004015 active site 990317004016 ATP binding site [chemical binding]; other site 990317004017 ABC1 family; Region: ABC1; cl17513 990317004018 Uncharacterized conserved protein [Function unknown]; Region: COG3937 990317004019 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 990317004020 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 990317004021 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 990317004022 PTS system, beta-glucoside-specific IIABC component; Region: PTS-II-ABC-beta; TIGR01995 990317004023 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 990317004024 active site turn [active] 990317004025 phosphorylation site [posttranslational modification] 990317004026 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 990317004027 PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_glc; cd00210 990317004028 HPr interaction site; other site 990317004029 glycerol kinase (GK) interaction site [polypeptide binding]; other site 990317004030 active site 990317004031 phosphorylation site [posttranslational modification] 990317004032 transcriptional antiterminator BglG; Provisional; Region: PRK09772 990317004033 CAT RNA binding domain; Region: CAT_RBD; smart01061 990317004034 PRD domain; Region: PRD; pfam00874 990317004035 PRD domain; Region: PRD; pfam00874 990317004036 ClC chloride channel EriC. This domain is found in the EriC chloride transporters that mediate the extreme acid resistance response in eubacteria and archaea. This response allows bacteria to survive in the acidic environments by decarboxylation-linked...; Region: EriC; cd01031 990317004037 Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038 990317004038 Cl- selectivity filter; other site 990317004039 Cl- binding residues [ion binding]; other site 990317004040 pore gating glutamate residue; other site 990317004041 dimer interface [polypeptide binding]; other site 990317004042 H+/Cl- coupling transport residue; other site 990317004043 TrkA-C domain; Region: TrkA_C; pfam02080 990317004044 Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687 990317004045 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 990317004046 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 990317004047 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 990317004048 dimer interface [polypeptide binding]; other site 990317004049 conserved gate region; other site 990317004050 putative PBP binding loops; other site 990317004051 ABC-ATPase subunit interface; other site 990317004052 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 990317004053 dimer interface [polypeptide binding]; other site 990317004054 conserved gate region; other site 990317004055 putative PBP binding loops; other site 990317004056 ABC-ATPase subunit interface; other site 990317004057 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 990317004058 ATP-binding cassette domain of the polyamine transporter; Region: ABC_PotA_N; cd03300 990317004059 Walker A/P-loop; other site 990317004060 ATP binding site [chemical binding]; other site 990317004061 Q-loop/lid; other site 990317004062 ABC transporter signature motif; other site 990317004063 Walker B; other site 990317004064 D-loop; other site 990317004065 H-loop/switch region; other site 990317004066 TOBE domain; Region: TOBE_2; pfam08402 990317004067 UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK13905 990317004068 FAD binding domain; Region: FAD_binding_4; pfam01565 990317004069 UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873 990317004070 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483 990317004071 catalytic center binding site [active] 990317004072 ATP binding site [chemical binding]; other site 990317004073 Dihydroneopterin aldolase (DHNA) and 7,8-dihydroneopterin triphosphate epimerase domain (DHNTPE); these enzymes have been designated folB and folX, respectively. Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and...; Region: DHNA_DHNTPE; cd00534 990317004074 homooctamer interface [polypeptide binding]; other site 990317004075 active site 990317004076 dihydropteroate synthase; Region: DHPS; TIGR01496 990317004077 DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739 990317004078 substrate binding pocket [chemical binding]; other site 990317004079 dimer interface [polypeptide binding]; other site 990317004080 inhibitor binding site; inhibition site 990317004081 GTP cyclohydrolase I (GTP-CH-I) catalyzes the conversion of GTP into dihydroneopterin triphosphate. The enzyme product is the precursor of tetrahydrofolate in eubacteria, fungi, and plants and of the folate analogs in methanogenic bacteria. In...; Region: GTP_cyclohydro1; cd00642 990317004082 homodecamer interface [polypeptide binding]; other site 990317004083 GTP cyclohydrolase I; Provisional; Region: PLN03044 990317004084 active site 990317004085 putative catalytic site residues [active] 990317004086 zinc binding site [ion binding]; other site 990317004087 GTP-CH-I/GFRP interaction surface; other site 990317004088 Folylpolyglutamate synthase [Coenzyme metabolism]; Region: FolC; COG0285 990317004089 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 990317004090 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 990317004091 Bacterial periplasmic substrate-binding proteins; Region: PBPb; smart00062 990317004092 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 990317004093 substrate binding pocket [chemical binding]; other site 990317004094 membrane-bound complex binding site; other site 990317004095 hinge residues; other site 990317004096 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 990317004097 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 990317004098 Walker A/P-loop; other site 990317004099 ATP binding site [chemical binding]; other site 990317004100 Q-loop/lid; other site 990317004101 ABC transporter signature motif; other site 990317004102 Walker B; other site 990317004103 D-loop; other site 990317004104 H-loop/switch region; other site 990317004105 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 990317004106 dimer interface [polypeptide binding]; other site 990317004107 conserved gate region; other site 990317004108 ABC-ATPase subunit interface; other site 990317004109 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 990317004110 dimer interface [polypeptide binding]; other site 990317004111 conserved gate region; other site 990317004112 putative PBP binding loops; other site 990317004113 ABC-ATPase subunit interface; other site 990317004114 aminodeoxychorismate synthase; Provisional; Region: PRK07508 990317004115 chorismate binding enzyme; Region: Chorismate_bind; cl10555 990317004116 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 990317004117 Aminotransferase class IV; Region: Aminotran_4; pfam01063 990317004118 substrate-cofactor binding pocket; other site 990317004119 pyridoxal 5'-phosphate binding site [chemical binding]; other site 990317004120 catalytic residue [active] 990317004121 Predicted permeases [General function prediction only]; Region: RarD; COG2962 990317004122 EamA-like transporter family; Region: EamA; pfam00892 990317004123 homoserine kinase; Provisional; Region: PRK01212 990317004124 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 990317004125 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 990317004126 homoserine dehydrogenase; Provisional; Region: PRK06349 990317004127 Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447 990317004128 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 990317004129 ACT_HSDH_Hom CD includes the C-terminal ACT domain of the NAD(P)H-dependent, homoserine dehydrogenase (HSDH) and related domains; Region: ACT_HSDH-Hom; cd04881 990317004130 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 990317004131 Putative catalytic NodB homology domain of PgaB, IcaB, and similar proteins which consist of a deformed (beta/alpha)8 barrel fold with 5- or 6-strands; Region: CE4_NodB_like_5s_6s; cd10918 990317004132 putative active site [active] 990317004133 putative metal binding site [ion binding]; other site 990317004134 probable dihydroxyacetone kinase regulator; Region: DHAK_reg; TIGR02366 990317004135 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 990317004136 Transcriptional regulator C-terminal region; Region: TetR_C_8; pfam14278 990317004137 Cro/C1-type HTH DNA-binding domain; Region: HTH_26; pfam13443 990317004138 Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387 990317004139 core dimer interface [polypeptide binding]; other site 990317004140 L10 interface [polypeptide binding]; other site 990317004141 L11 interface [polypeptide binding]; other site 990317004142 putative EF-Tu interaction site [polypeptide binding]; other site 990317004143 putative EF-G interaction site [polypeptide binding]; other site 990317004144 Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797 990317004145 23S rRNA interface [nucleotide binding]; other site 990317004146 Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site 990317004147 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 990317004148 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 990317004149 Walker A motif; other site 990317004150 ATP binding site [chemical binding]; other site 990317004151 ATPases of the AAA+ class [Posttranslational modification, protein turnover, chaperones]; Region: SpoVK; COG0464 990317004152 Walker B motif; other site 990317004153 arginine finger; other site 990317004154 UvrB/uvrC motif; Region: UVR; pfam02151 990317004155 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 990317004156 Walker A motif; other site 990317004157 ATP binding site [chemical binding]; other site 990317004158 Walker B motif; other site 990317004159 arginine finger; other site 990317004160 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 990317004161 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 990317004162 endonuclease III; Region: ENDO3c; smart00478 990317004163 minor groove reading motif; other site 990317004164 helix-hairpin-helix signature motif; other site 990317004165 substrate binding pocket [chemical binding]; other site 990317004166 active site 990317004167 Protein of unknown function (DUF1275); Region: DUF1275; pfam06912 990317004168 homocysteine methyltransferase; Provisional; Region: mmuM; PRK09485 990317004169 Homocysteine S-methyltransferase; Region: S-methyl_trans; pfam02574 990317004170 S-methylmethionine transporter; Provisional; Region: PRK11387 990317004171 YihA (EngB) GTPase family; Region: YihA_EngB; cd01876 990317004172 G1 box; other site 990317004173 GTP/Mg2+ binding site [chemical binding]; other site 990317004174 Switch I region; other site 990317004175 G2 box; other site 990317004176 G3 box; other site 990317004177 Switch II region; other site 990317004178 G4 box; other site 990317004179 G5 box; other site 990317004180 ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342 990317004181 ClpX C4-type zinc finger; Region: zf-C4_ClpX; pfam06689 990317004182 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 990317004183 Walker A motif; other site 990317004184 ATP binding site [chemical binding]; other site 990317004185 Walker B motif; other site 990317004186 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 990317004187 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 990317004188 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cd00209 990317004189 folate binding site [chemical binding]; other site 990317004190 NADP+ binding site [chemical binding]; other site 990317004191 thymidylate synthase; Reviewed; Region: thyA; PRK01827 990317004192 Thymidylate synthase and pyrimidine hydroxymethylase: Thymidylate synthase (TS) and deoxycytidylate hydroxymethylase (dCMP-HMase) are homologs that catalyze analogous alkylation of C5 of pyrimidine nucleotides. Both enzymes are involved in the...; Region: TS_Pyrimidine_HMase; cd00351 990317004193 dimerization interface [polypeptide binding]; other site 990317004194 active site 990317004195 "initiating" condensing enzymes are a subclass of decarboxylating condensing enzymes, including beta-ketoacyl [ACP] synthase, type III and polyketide synthases, type III, which include chalcone synthase and related enzymes. They are...; Region: init_cond_enzymes; cd00827 990317004196 3-hydroxy-3-methylglutaryl CoA synthase, prokaryotic clade; Region: HMG-CoA-S_prok; TIGR01835 990317004197 dimer interface [polypeptide binding]; other site 990317004198 active site 990317004199 Class II hydroxymethylglutaryl-coenzyme A (HMG-CoA) reductase (HMGR); Region: HMG-CoA_reductase_classII; cd00644 990317004200 homodimer interface [polypeptide binding]; other site 990317004201 catalytic residues [active] 990317004202 NAD binding site [chemical binding]; other site 990317004203 substrate binding pocket [chemical binding]; other site 990317004204 flexible flap; other site 990317004205 Domain of unknown function (DUF1836); Region: DUF1836; pfam08876 990317004206 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 990317004207 Predicted membrane protein, hemolysin III homolog [General function prediction only]; Region: COG1272 990317004208 channel protein, hemolysin III family; Region: hlyIII; TIGR01065 990317004209 isopentenyl pyrophosphate isomerase; Provisional; Region: PRK05437 990317004210 Isopentenyl-diphosphate:dimethylallyl diphosphate isomerase type 2 (IDI-2) FMN-binding domain. Two types of IDIs have been characterized at present. The long known IDI-1 is only dependent on divalent metals for activity, whereas IDI-2 requires a metal; Region: IDI-2_FMN; cd02811 990317004211 homotetramer interface [polypeptide binding]; other site 990317004212 FMN binding site [chemical binding]; other site 990317004213 homodimer contacts [polypeptide binding]; other site 990317004214 putative active site [active] 990317004215 putative substrate binding site [chemical binding]; other site 990317004216 phosphomevalonate kinase, ERG8-type, Gram-positive branch; Region: Pmev_kin_Gr_pos; TIGR01220 990317004217 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 990317004218 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 990317004219 diphosphomevalonate decarboxylase; Region: PLN02407 990317004220 diphosphomevalonate decarboxylase; Region: mevDPdecarb; TIGR01240 990317004221 mevalonate kinase; Region: mevalon_kin; TIGR00549 990317004222 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 990317004223 Predicted glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: ECM4; COG0435 990317004224 C-terminal, alpha helical domain of Class Omega-like Glutathione S-transferases; Region: GST_C_Omega_like; cd03190 990317004225 putative dimer interface [polypeptide binding]; other site 990317004226 N-terminal domain interface [polypeptide binding]; other site 990317004227 putative substrate binding pocket (H-site) [chemical binding]; other site 990317004228 Predicted glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: ECM4; COG0435 990317004229 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 990317004230 C-terminal, alpha helical domain of Class Omega-like Glutathione S-transferases; Region: GST_C_Omega_like; cd03190 990317004231 putative dimer interface [polypeptide binding]; other site 990317004232 N-terminal domain interface [polypeptide binding]; other site 990317004233 putative substrate binding pocket (H-site) [chemical binding]; other site 990317004234 Acetyltransferase (GNAT) domain; Region: Acetyltransf_7; pfam13508 990317004235 Coenzyme A binding pocket [chemical binding]; other site 990317004236 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 990317004237 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 990317004238 substrate binding pocket [chemical binding]; other site 990317004239 membrane-bound complex binding site; other site 990317004240 hinge residues; other site 990317004241 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 990317004242 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 990317004243 Walker A/P-loop; other site 990317004244 ATP binding site [chemical binding]; other site 990317004245 Q-loop/lid; other site 990317004246 ABC transporter signature motif; other site 990317004247 Walker B; other site 990317004248 D-loop; other site 990317004249 H-loop/switch region; other site 990317004250 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 990317004251 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 990317004252 dimer interface [polypeptide binding]; other site 990317004253 conserved gate region; other site 990317004254 putative PBP binding loops; other site 990317004255 ABC-ATPase subunit interface; other site 990317004256 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 990317004257 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 990317004258 dimer interface [polypeptide binding]; other site 990317004259 conserved gate region; other site 990317004260 putative PBP binding loops; other site 990317004261 ABC-ATPase subunit interface; other site 990317004262 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 990317004263 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 990317004264 substrate binding pocket [chemical binding]; other site 990317004265 membrane-bound complex binding site; other site 990317004266 hinge residues; other site 990317004267 The URO-D _like protein superfamily includes bacterial and eukaryotic uroporphyrinogen decarboxylases (URO-D), coenzyme M methyltransferases and other putative bacterial methyltransferases. Uroporphyrinogen decarboxylase (URO-D) decarboxylates the four...; Region: URO-D_like; cd03465 990317004268 Transcriptional regulator [Transcription]; Region: LysR; COG0583 990317004269 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 990317004270 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 990317004271 dimerization interface [polypeptide binding]; other site 990317004272 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 990317004273 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 990317004274 active site 990317004275 catalytic tetrad [active] 990317004276 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 990317004277 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 990317004278 dimer interface [polypeptide binding]; other site 990317004279 phosphorylation site [posttranslational modification] 990317004280 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 990317004281 ATP binding site [chemical binding]; other site 990317004282 Mg2+ binding site [ion binding]; other site 990317004283 G-X-G motif; other site 990317004284 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 990317004285 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 990317004286 active site 990317004287 phosphorylation site [posttranslational modification] 990317004288 intermolecular recognition site; other site 990317004289 dimerization interface [polypeptide binding]; other site 990317004290 Transcriptional regulatory protein, C terminal; Region: Trans_reg_C; smart00862 990317004291 DNA binding site [nucleotide binding] 990317004292 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 990317004293 synthetase active site [active] 990317004294 NTP binding site [chemical binding]; other site 990317004295 metal binding site [ion binding]; metal-binding site 990317004296 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 990317004297 dimer interface [polypeptide binding]; other site 990317004298 conserved gate region; other site 990317004299 ABC-ATPase subunit interface; other site 990317004300 sulfate ABC transporter, ATP-binding protein; Region: 3a0106s01; TIGR00968 990317004301 ATP-binding cassette domain of the osmoprotectant transporter; Region: ABC_OpuCA_Osmoprotection; cd03295 990317004302 Walker A/P-loop; other site 990317004303 ATP binding site [chemical binding]; other site 990317004304 Q-loop/lid; other site 990317004305 ABC transporter signature motif; other site 990317004306 Walker B; other site 990317004307 D-loop; other site 990317004308 H-loop/switch region; other site 990317004309 Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069 990317004310 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 990317004311 ABC-ATPase subunit interface; other site 990317004312 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 990317004313 MarR family; Region: MarR_2; pfam12802 990317004314 MarR family; Region: MarR_2; cl17246 990317004315 Quinone oxidoreductase (QOR); Region: quinone_oxidoreductase_like_1; cd08243 990317004316 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 990317004317 putative NAD(P) binding site [chemical binding]; other site 990317004318 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 990317004319 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 990317004320 ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254 990317004321 Walker A/P-loop; other site 990317004322 ATP binding site [chemical binding]; other site 990317004323 Q-loop/lid; other site 990317004324 ABC transporter signature motif; other site 990317004325 Walker B; other site 990317004326 D-loop; other site 990317004327 H-loop/switch region; other site 990317004328 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 990317004329 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 990317004330 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 990317004331 Walker A/P-loop; other site 990317004332 ATP binding site [chemical binding]; other site 990317004333 Q-loop/lid; other site 990317004334 ABC transporter signature motif; other site 990317004335 Walker B; other site 990317004336 D-loop; other site 990317004337 H-loop/switch region; other site 990317004338 Transcriptional regulators [Transcription]; Region: MarR; COG1846 990317004339 MarR family; Region: MarR_2; pfam12802 990317004340 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 990317004341 active site 990317004342 catalytic residues [active] 990317004343 metal binding site [ion binding]; metal-binding site 990317004344 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 990317004345 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 990317004346 Coenzyme A binding pocket [chemical binding]; other site 990317004347 glutamate dehydrogenase; Provisional; Region: PRK09414 990317004348 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 990317004349 NAD(P) binding domain of glutamate dehydrogenase, subgroup 2; Region: NAD_bind_2_Glu_DH; cd05313 990317004350 NAD(P) binding site [chemical binding]; other site 990317004351 Enzyme related to GTP cyclohydrolase I [General function prediction only]; Region: COG0780 990317004352 7-cyano-7-deazaguanosine (preQ0) biosynthesis protein QueE; Region: Bsubt_queE; TIGR03365 990317004353 putative 7-cyano-7-deazaguanosine (preQ0) biosynthesis protein QueE; Region: rSAM_QueE_Ecoli; TIGR04322 990317004354 6-pyruvoyl tetrahydropterin synthase; Region: PTPS; pfam01242 990317004355 active site 990317004356 ExsB is a transcription regulator related protein. It is a subfamily of a Adenosine nucleotide binding superfamily of proteins. This protein family is represented by a single member in nearly every completed large (> 1000 genes) prokaryotic genome. In...; Region: ExsB; cd01995 990317004357 Ligand Binding Site [chemical binding]; other site 990317004358 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 990317004359 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 990317004360 ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254 990317004361 Walker A/P-loop; other site 990317004362 ATP binding site [chemical binding]; other site 990317004363 Q-loop/lid; other site 990317004364 ABC transporter signature motif; other site 990317004365 Walker B; other site 990317004366 D-loop; other site 990317004367 H-loop/switch region; other site 990317004368 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 990317004369 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 990317004370 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 990317004371 Walker A/P-loop; other site 990317004372 ATP binding site [chemical binding]; other site 990317004373 Q-loop/lid; other site 990317004374 ABC transporter signature motif; other site 990317004375 Walker B; other site 990317004376 D-loop; other site 990317004377 H-loop/switch region; other site 990317004378 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 990317004379 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 990317004380 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 990317004381 ABC transporter; Region: ABC_tran_2; pfam12848 990317004382 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 990317004383 tRNA CCA-pyrophosphorylase; Provisional; Region: PRK13299 990317004384 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 990317004385 active site 990317004386 NTP binding site [chemical binding]; other site 990317004387 metal binding triad [ion binding]; metal-binding site 990317004388 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 990317004389 tRNA nucleotidyltransferase domain 2 putative; Region: tRNA_NucTran2_2; pfam13735 990317004390 dihydrodipicolinate reductase; Provisional; Region: PRK00048 990317004391 Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113 990317004392 Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173 990317004393 EDD domain protein, DegV family; Region: DegV; TIGR00762 990317004394 Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645 990317004395 Protein of unknown function (DUF1149); Region: DUF1149; pfam06619 990317004396 Muramidase (flagellum-specific) [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FlgJ; COG1705 990317004397 1-deoxy-D-xylulose-5-phosphate synthase; Provisional; Region: PRK12315 990317004398 Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007 990317004399 TPP-binding site; other site 990317004400 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 990317004401 PYR/PP interface [polypeptide binding]; other site 990317004402 dimer interface [polypeptide binding]; other site 990317004403 TPP binding site [chemical binding]; other site 990317004404 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 990317004405 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 990317004406 atypical (a) SDRs, subgroup 5; Region: SDR_a5; cd05243 990317004407 NADH(P)-binding; Region: NAD_binding_10; pfam13460 990317004408 NAD(P) binding site [chemical binding]; other site 990317004409 putative active site [active] 990317004410 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 990317004411 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 990317004412 active site 990317004413 catalytic tetrad [active] 990317004414 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 990317004415 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 990317004416 active site 990317004417 catalytic tetrad [active] 990317004418 Bacterial low temperature requirement A protein (LtrA); Region: LtrA; cl01754 990317004419 bifunctional homocysteine S-methyltransferase/5,10-methylenetetrahydrofolate reductase protein; Reviewed; Region: PRK08645 990317004420 Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; cl14105 990317004421 Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cd00537 990317004422 FAD binding site [chemical binding]; other site 990317004423 5-methyltetrahydropteroyltriglutamate--homocysteine S-methyltransferase; Provisional; Region: PRK05222 990317004424 CIMS - Cobalamine-independent methonine synthase, or MetE, N-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_N_terminal_like; cd03312 990317004425 THF binding site; other site 990317004426 CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311 990317004427 substrate binding site [chemical binding]; other site 990317004428 THF binding site; other site 990317004429 zinc-binding site [ion binding]; other site 990317004430 PTS system 2-O-a-mannosyl-D-glycerate specific transporter subunit IIABC; Provisional; Region: PRK09765 990317004431 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 990317004432 active site 990317004433 phosphorylation site [posttranslational modification] 990317004434 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569 990317004435 active site 990317004436 P-loop; other site 990317004437 phosphorylation site [posttranslational modification] 990317004438 Phosphotransferase system, fructose-specific IIC component [Carbohydrate transport and metabolism]; Region: FruA; COG1299 990317004439 Fructose-1-phosphate kinase and related fructose-6-phosphate kinase (PfkB) [Carbohydrate transport and metabolism]; Region: FruK; COG1105 990317004440 1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164 990317004441 putative substrate binding site [chemical binding]; other site 990317004442 putative ATP binding site [chemical binding]; other site 990317004443 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 990317004444 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 990317004445 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 990317004446 Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492 990317004447 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 990317004448 Uncharacterized protein family (UPF0157); Region: UPF0157; pfam04229 990317004449 tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026 990317004450 16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK00122 990317004451 RimM N-terminal domain; Region: RimM; pfam01782 990317004452 PRC-barrel domain; Region: PRC; pfam05239 990317004453 Predicted RNA-binding protein (contains KH domain) [General function prediction only]; Region: COG1837 990317004454 KH domain; Region: KH_4; pfam13083 990317004455 G-X-X-G motif; other site 990317004456 Ribosomal protein S16 [Translation, ribosomal structure and biogenesis]; Region: RpsP; COG0228 990317004457 Putative SAM-dependent methyltransferase; Region: SAM_MT; cl17517 990317004458 Uncharacterized conserved protein [Function unknown]; Region: COG0398 990317004459 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 990317004460 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 990317004461 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 990317004462 FtsX-like permease family; Region: FtsX; pfam02687 990317004463 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 990317004464 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 990317004465 Walker A/P-loop; other site 990317004466 ATP binding site [chemical binding]; other site 990317004467 Q-loop/lid; other site 990317004468 ABC transporter signature motif; other site 990317004469 Walker B; other site 990317004470 D-loop; other site 990317004471 H-loop/switch region; other site 990317004472 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 990317004473 HlyD family secretion protein; Region: HlyD_3; pfam13437 990317004474 carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294 990317004475 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 990317004476 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 990317004477 Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787 990317004478 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 990317004479 ATP-grasp domain; Region: ATP-grasp_4; cl17255 990317004480 Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424 990317004481 IMP binding site; other site 990317004482 dimer interface [polypeptide binding]; other site 990317004483 interdomain contacts; other site 990317004484 partial ornithine binding site; other site 990317004485 carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564 990317004486 Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; smart01097 990317004487 Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744 990317004488 catalytic site [active] 990317004489 subunit interface [polypeptide binding]; other site 990317004490 aspartate carbamoyltransferase catalytic subunit; Provisional; Region: pyrB; PRK00856 990317004491 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 990317004492 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 990317004493 uracil transporter; Provisional; Region: PRK10720 990317004494 Pyrimidine operon attenuation protein/uracil phosphoribosyltransferase [Nucleotide transport and metabolism]; Region: PyrR; COG2065 990317004495 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 990317004496 active site 990317004497 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 990317004498 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 990317004499 RNA binding surface [nucleotide binding]; other site 990317004500 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 990317004501 active site 990317004502 lipoprotein signal peptidase; Provisional; Region: PRK14797 990317004503 lipoprotein signal peptidase; Provisional; Region: PRK14787 990317004504 Transcriptional regulator [Transcription]; Region: LysR; COG0583 990317004505 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 990317004506 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 990317004507 dimerization interface [polypeptide binding]; other site 990317004508 50S ribosomal protein L27; Validated; Region: rpmA; PRK05435 990317004509 Protein of unknown function (DUF464); Region: DUF464; pfam04327 990317004510 50S ribosomal protein L21; Validated; Region: rplU; PRK05573 990317004511 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 990317004512 Coenzyme A binding pocket [chemical binding]; other site 990317004513 Putative enzyme of poly-gamma-glutamate biosynthesis (capsule formation) [Cell envelope biogenesis, outer membrane]; Region: PgsA; COG2843 990317004514 CapA and related proteins, metallophosphatase domain; Region: MPP_CapA; cd07381 990317004515 putative active site [active] 990317004516 putative metal binding site [ion binding]; other site 990317004517 thiamine biosynthesis protein ThiI; Provisional; Region: PRK01565 990317004518 THUMP domain of thiamine biosynthesis protein ThiI; Region: THUMP_ThiI; cd11716 990317004519 ThiI is required for thiazole synthesis in the thiamine biosynthesis pathway. It belongs to the Adenosine Nucleotide Hydrolysis suoerfamily and predicted to bind to Adenosine nucleotide; Region: ThiI; cd01712 990317004520 Ligand Binding Site [chemical binding]; other site 990317004521 Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104 990317004522 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 990317004523 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 990317004524 catalytic residue [active] 990317004525 folylpolyglutamate synthase/dihydrofolate synthase; Region: folC; TIGR01499 990317004526 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 990317004527 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 990317004528 L-2-hydroxyisocapronate dehydrogenases and some bacterial L-lactate dehydrogenases; Region: HicDH_like; cd05291 990317004529 tetramer (dimer of dimers) interface [polypeptide binding]; other site 990317004530 L-lactate dehydrogenase; Region: L-LDH-NAD; TIGR01771 990317004531 NAD binding site [chemical binding]; other site 990317004532 dimer interface [polypeptide binding]; other site 990317004533 substrate binding site [chemical binding]; other site 990317004534 hypothetical protein; Provisional; Region: PRK13676 990317004535 prephenate dehydrogenase; Validated; Region: PRK06545 990317004536 prephenate dehydrogenase; Validated; Region: PRK08507 990317004537 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 990317004538 Chorismate synthase [Amino acid transport and metabolism]; Region: AroC; COG0082 990317004539 Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304 990317004540 Tetramer interface [polypeptide binding]; other site 990317004541 active site 990317004542 FMN-binding site [chemical binding]; other site 990317004543 Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195 990317004544 Iron-containing alcohol dehydrogenase; Region: Fe-ADH; pfam00465 990317004545 active site 990317004546 dimer interface [polypeptide binding]; other site 990317004547 metal binding site [ion binding]; metal-binding site 990317004548 shikimate 5-dehydrogenase; Reviewed; Region: aroE; PRK00258 990317004549 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 990317004550 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 990317004551 shikimate binding site; other site 990317004552 NAD(P) binding site [chemical binding]; other site 990317004553 3-dehydroquinate dehydratase [Amino acid transport and metabolism]; Region: AroD; COG0710 990317004554 Type I 3-dehydroquinase, (3-dehydroquinate dehydratase or DHQase); Region: DHQase_I; cd00502 990317004555 active site 990317004556 catalytic residue [active] 990317004557 dimer interface [polypeptide binding]; other site 990317004558 Predicted SAM-dependent methyltransferases [General function prediction only]; Region: COG1092 990317004559 Middle domain of the SAM-dependent methyltransferase RlmI and related proteins; Region: RlmI_M_like; cd11572 990317004560 putative RNA binding site [nucleotide binding]; other site 990317004561 Methyltransferase domain; Region: Methyltransf_26; pfam13659 990317004562 Phosphoglycerol transferase and related proteins, alkaline phosphatase superfamily [Cell envelope biogenesis, outer membrane]; Region: MdoB; COG1368 990317004563 Sulfatase; Region: Sulfatase; pfam00884 990317004564 RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651 990317004565 Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078 990317004566 putative active site [active] 990317004567 putative NTP binding site [chemical binding]; other site 990317004568 putative nucleic acid binding site [nucleotide binding]; other site 990317004569 Group II intron, maturase-specific domain; Region: GIIM; pfam08388 990317004570 Ribosomal protein L20; Region: Ribosomal_L20; cd07026 990317004571 23S rRNA binding site [nucleotide binding]; other site 990317004572 L21 binding site [polypeptide binding]; other site 990317004573 L13 binding site [polypeptide binding]; other site 990317004574 50S ribosomal protein L35; Reviewed; Region: rpmI; PRK00172 990317004575 translation initiation factor IF-3; Reviewed; Region: infC; PRK00028 990317004576 Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198 990317004577 Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707 990317004578 cytidylate kinase; Provisional; Region: cmk; PRK00023 990317004579 Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020 990317004580 CMP-binding site; other site 990317004581 The sites determining sugar specificity; other site 990317004582 Ferredoxin [Energy production and conversion]; Region: Fer; COG1141 990317004583 peptidase T; Region: peptidase-T; TIGR01882 990317004584 M20 Peptidase T specifically cleaves tripeptides; Region: M20_peptT; cd03892 990317004585 metal binding site [ion binding]; metal-binding site 990317004586 dimer interface [polypeptide binding]; other site 990317004587 GBS Bsp-like repeat; Region: GBS_Bsp-like; pfam08481 990317004588 GBS Bsp-like repeat; Region: GBS_Bsp-like; pfam08481 990317004589 GBS Bsp-like repeat; Region: GBS_Bsp-like; pfam08481 990317004590 GBS Bsp-like repeat; Region: GBS_Bsp-like; pfam08481 990317004591 GBS Bsp-like repeat; Region: GBS_Bsp-like; pfam08481 990317004592 GBS Bsp-like repeat; Region: GBS_Bsp-like; pfam08481 990317004593 Endo-N-acetylmuramidases (muramidases) are lysozymes (also referred to as peptidoglycan hydrolases) that degrade bacterial cell walls by catalyzing the hydrolysis of 1,4-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues; Region: GH25_muramidase; cl10448 990317004594 Glycosyl hydrolases family 25; Region: Glyco_hydro_25; pfam01183 990317004595 active site 990317004596 GBS Bsp-like repeat; Region: GBS_Bsp-like; pfam08481 990317004597 GBS Bsp-like repeat; Region: GBS_Bsp-like; pfam08481 990317004598 GBS Bsp-like repeat; Region: GBS_Bsp-like; pfam08481 990317004599 Surface antigen [General function prediction only]; Region: COG3942 990317004600 CHAP domain; Region: CHAP; pfam05257 990317004601 GBS Bsp-like repeat; Region: GBS_Bsp-like; pfam08481 990317004602 undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714 990317004603 Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187 990317004604 Ligand binding site; other site 990317004605 Putative Catalytic site; other site 990317004606 DXD motif; other site 990317004607 Glucosyl transferase GtrII; Region: Glucos_trans_II; pfam14264 990317004608 Uncharacterized protein family (UPF0236); Region: UPF0236; pfam06782 990317004609 Enterocin A Immunity; Region: EntA_Immun; pfam08951 990317004610 Stage 0 sporulation protein J (antagonist of Soj) containing ParB-like nuclease domain [Transcription]; Region: Spo0J; COG1475 990317004611 ParB-like nuclease domain; Region: ParBc; pfam02195 990317004612 DNA modification methylase [DNA replication, recombination, and repair]; Region: COG0863 990317004613 DNA methylase; Region: N6_N4_Mtase; pfam01555 990317004614 Relaxase/Mobilisation nuclease domain; Region: Relaxase; pfam03432 990317004615 Bacterial mobilisation protein (MobC); Region: MobC; pfam05713 990317004616 Protein of unknown function (DUF3991); Region: DUF3991; pfam13154 990317004617 Toprim-like; Region: Toprim_2; pfam13155 990317004618 Domain of unknown function (DUF955); Region: DUF955; cl01076 990317004619 AAA-like domain; Region: AAA_10; pfam12846 990317004620 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 990317004621 Walker A motif; other site 990317004622 ATP binding site [chemical binding]; other site 990317004623 Walker B motif; other site 990317004624 CHAP domain; Region: CHAP; pfam05257 990317004625 Surface antigen [General function prediction only]; Region: COG3942 990317004626 AAA-like domain; Region: AAA_10; pfam12846 990317004627 PrgI family protein; Region: PrgI; pfam12666 990317004628 potential frameshift: common BLAST hit: gi|288905868|ref|YP_003431090.1| peptidoglycan linked protein (LPXTG motif) 990317004629 LPXTG-motif cell wall anchor domain; Region: LPXTG_anchor; TIGR01167 990317004630 putative cross-wall-targeting lipoprotein signal; Region: strep_RK_lipo; TIGR03726 990317004631 LPXTG-motif cell wall anchor domain; Region: LPXTG_anchor; TIGR01167 990317004632 Replication initiator protein A (RepA) N-terminus; Region: RepA_N; pfam06970 990317004633 Phosphoglycerol transferase and related proteins, alkaline phosphatase superfamily [Cell envelope biogenesis, outer membrane]; Region: MdoB; COG1368 990317004634 Sulfatase; Region: Sulfatase; pfam00884 990317004635 Rhamnan synthesis protein F; Region: RgpF; pfam05045 990317004636 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 990317004637 active site 990317004638 ABC-type polysaccharide/polyol phosphate transport system, ATPase component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagH; COG1134 990317004639 ATP-binding cassette component of polysaccharide transport system; Region: ABC_KpsT_Wzt; cd03220 990317004640 Walker A/P-loop; other site 990317004641 ATP binding site [chemical binding]; other site 990317004642 Q-loop/lid; other site 990317004643 ABC transporter signature motif; other site 990317004644 Walker B; other site 990317004645 D-loop; other site 990317004646 H-loop/switch region; other site 990317004647 ABC-type polysaccharide/polyol phosphate export systems, permease component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagG; COG1682 990317004648 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 990317004649 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 990317004650 Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_d; cd04196 990317004651 Probable Catalytic site; other site 990317004652 This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_6; cd04955 990317004653 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 990317004654 dTDP-6-deoxy-L-lyxo-4-hexulose reductase and related proteins, extended (e) SDRs; Region: dTDP_HR_like_SDR_e; cd05254 990317004655 RmlD substrate binding domain; Region: RmlD_sub_bind; pfam04321 990317004656 NADP binding site [chemical binding]; other site 990317004657 active site 990317004658 putative substrate binding site [chemical binding]; other site 990317004659 Predicted metal-sulfur cluster biosynthetic enzyme [General function prediction only]; Region: PaaD; COG2151 990317004660 RNA polymerase sigma factor RpoD; Validated; Region: PRK09210 990317004661 Sigma-70 factor, region 1.1; Region: Sigma70_r1_1; pfam03979 990317004662 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 990317004663 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 990317004664 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 990317004665 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 990317004666 DNA binding residues [nucleotide binding] 990317004667 DNA primase, catalytic core; Region: dnaG; TIGR01391 990317004668 CHC2 zinc finger; Region: zf-CHC2; pfam01807 990317004669 DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275 990317004670 TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364 990317004671 active site 990317004672 metal binding site [ion binding]; metal-binding site 990317004673 interdomain interaction site; other site 990317004674 Large-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscL; COG1970 990317004675 large-conductance mechanosensitive channel; Reviewed; Region: mscL; PRK00567 990317004676 30S ribosomal protein S21; Reviewed; Region: rpsU; PRK00270 990317004677 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 990317004678 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_16; cd07263 990317004679 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 990317004680 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 990317004681 substrate binding pocket [chemical binding]; other site 990317004682 membrane-bound complex binding site; other site 990317004683 hinge residues; other site 990317004684 transaminase; Validated; Region: PRK07324 990317004685 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 990317004686 pyridoxal 5'-phosphate binding site [chemical binding]; other site 990317004687 homodimer interface [polypeptide binding]; other site 990317004688 catalytic residue [active] 990317004689 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 990317004690 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 990317004691 substrate binding pocket [chemical binding]; other site 990317004692 membrane-bound complex binding site; other site 990317004693 hinge residues; other site 990317004694 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 990317004695 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 990317004696 substrate binding pocket [chemical binding]; other site 990317004697 membrane-bound complex binding site; other site 990317004698 hinge residues; other site 990317004699 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 990317004700 glycogen/starch/alpha-glucan phosphorylases; Region: P_ylase; TIGR02093 990317004701 4-alpha-glucanotransferase; Provisional; Region: PRK14508 990317004702 Transcriptional regulators [Transcription]; Region: PurR; COG1609 990317004703 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 990317004704 DNA binding site [nucleotide binding] 990317004705 domain linker motif; other site 990317004706 Ligand-binding domain of uncharacterized transcription regulator ycjW which is a member of the LacI-GalR family repressors; Region: PBP1_ycjW_transcription_regulator_like; cd06294 990317004707 putative dimerization interface [polypeptide binding]; other site 990317004708 putative ligand binding site [chemical binding]; other site 990317004709 Maltose-binding periplasmic proteins/domains [Carbohydrate transport and metabolism]; Region: MalE; COG2182 990317004710 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 990317004711 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 990317004712 dimer interface [polypeptide binding]; other site 990317004713 conserved gate region; other site 990317004714 putative PBP binding loops; other site 990317004715 ABC-ATPase subunit interface; other site 990317004716 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 990317004717 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 990317004718 dimer interface [polypeptide binding]; other site 990317004719 conserved gate region; other site 990317004720 putative PBP binding loops; other site 990317004721 ABC-ATPase subunit interface; other site 990317004722 MutT homolog-1 (MTH1) is a member of the Nudix hydrolase superfamily. MTH1, the mammalian counterpart of MutT, hydrolyzes oxidized purine nucleoside triphosphates, such as 8-oxo-dGTP and 2-hydroxy-ATP, to monophosphates, thereby preventing the...; Region: MTH1; cd03427 990317004723 putative active site [active] 990317004724 nucleotide binding site [chemical binding]; other site 990317004725 nudix motif; other site 990317004726 putative metal binding site [ion binding]; other site 990317004727 excinuclease ABC subunit B; Provisional; Region: PRK05298 990317004728 Myosin and Kinesin motor domain. These ATPases belong to the P-loop NTPase family and provide the driving force in myosin and kinesin mediated processes; Region: Motor_domain; cl00286 990317004729 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 990317004730 ATP-binding site [chemical binding]; other site 990317004731 ATP binding site [chemical binding]; other site 990317004732 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 990317004733 nucleotide binding region [chemical binding]; other site 990317004734 ATP-binding site [chemical binding]; other site 990317004735 Ultra-violet resistance protein B; Region: UvrB; pfam12344 990317004736 UvrB/uvrC motif; Region: UVR; pfam02151 990317004737 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 990317004738 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 990317004739 substrate binding pocket [chemical binding]; other site 990317004740 membrane-bound complex binding site; other site 990317004741 hinge residues; other site 990317004742 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 990317004743 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 990317004744 substrate binding pocket [chemical binding]; other site 990317004745 membrane-bound complex binding site; other site 990317004746 hinge residues; other site 990317004747 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 990317004748 dimer interface [polypeptide binding]; other site 990317004749 conserved gate region; other site 990317004750 putative PBP binding loops; other site 990317004751 ABC-ATPase subunit interface; other site 990317004752 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 990317004753 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 990317004754 Walker A/P-loop; other site 990317004755 ATP binding site [chemical binding]; other site 990317004756 Q-loop/lid; other site 990317004757 ABC transporter signature motif; other site 990317004758 Walker B; other site 990317004759 D-loop; other site 990317004760 H-loop/switch region; other site 990317004761 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 990317004762 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 990317004763 Walker A/P-loop; other site 990317004764 ATP binding site [chemical binding]; other site 990317004765 Q-loop/lid; other site 990317004766 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 990317004767 H-loop/switch region; other site 990317004768 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 990317004769 GTPase CgtA; Reviewed; Region: obgE; PRK12297 990317004770 GTP1/OBG; Region: GTP1_OBG; pfam01018 990317004771 Obg GTPase; Region: Obg; cd01898 990317004772 G1 box; other site 990317004773 GTP/Mg2+ binding site [chemical binding]; other site 990317004774 Switch I region; other site 990317004775 G2 box; other site 990317004776 G3 box; other site 990317004777 Switch II region; other site 990317004778 G4 box; other site 990317004779 G5 box; other site 990317004780 Domain of unknown function (DUF1967); Region: DUF1967; pfam09269 990317004781 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 990317004782 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 990317004783 RNA binding surface [nucleotide binding]; other site 990317004784 Pseudouridine synthase, Escherichia coli RsuA like; Region: PseudoU_synth_RsuA; cd02553 990317004785 active site 990317004786 uracil binding [chemical binding]; other site 990317004787 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 990317004788 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 990317004789 peptide binding site [polypeptide binding]; other site 990317004790 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 990317004791 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 990317004792 peptide binding site [polypeptide binding]; other site 990317004793 MarR family; Region: MarR_2; cl17246 990317004794 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 990317004795 Predicted membrane protein [Function unknown]; Region: COG2364 990317004796 Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792 990317004797 putative transporter; Provisional; Region: PRK11660 990317004798 Sulfate transporter family; Region: Sulfate_transp; pfam00916 990317004799 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 990317004800 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 990317004801 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 990317004802 non-specific DNA binding site [nucleotide binding]; other site 990317004803 salt bridge; other site 990317004804 sequence-specific DNA binding site [nucleotide binding]; other site 990317004805 Putative zinc ribbon domain; Region: Zn_ribbon_2; pfam12674 990317004806 Metallo-beta-lactamase superfamily; Region: Lactamase_B; pfam00753 990317004807 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 990317004808 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 990317004809 nucleoside/Zn binding site; other site 990317004810 dimer interface [polypeptide binding]; other site 990317004811 catalytic motif [active] 990317004812 Cupin domain; Region: Cupin_2; pfam07883 990317004813 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 990317004814 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 990317004815 Coenzyme A binding pocket [chemical binding]; other site 990317004816 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 990317004817 Coenzyme A binding pocket [chemical binding]; other site 990317004818 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 990317004819 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 990317004820 Coenzyme A binding pocket [chemical binding]; other site 990317004821 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 990317004822 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 990317004823 Predicted permeases [General function prediction only]; Region: COG0679 990317004824 CAAX protease self-immunity; Region: Abi; pfam02517 990317004825 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 990317004826 Coenzyme A binding pocket [chemical binding]; other site 990317004827 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 990317004828 Coenzyme A binding pocket [chemical binding]; other site 990317004829 SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase [Translation, ribosomal structure and biogenesis]; Region: TrmA; COG2265 990317004830 Predicted RNA-binding protein, contains TRAM domain [General function prediction only]; Region: COG3269 990317004831 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 990317004832 S-adenosylmethionine binding site [chemical binding]; other site 990317004833 potential frameshift: common BLAST hit: gi|307067542|ref|YP_003876508.1| prophage maintenance system killer protein 990317004834 Fic/DOC family; Region: Fic; cl00960 990317004835 Fic/DOC family; Region: Fic; cl00960 990317004836 Antidote-toxin recognition MazE; Region: Antitoxin-MazE; cl00877 990317004837 Transcriptional regulator [Transcription]; Region: LytR; COG1316 990317004838 prephenate dehydratase; Provisional; Region: PRK11898 990317004839 Prephenate dehydratase; Region: PDT; pfam00800 990317004840 C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905 990317004841 putative L-Phe binding site [chemical binding]; other site 990317004842 Shikimate kinase [Amino acid transport and metabolism]; Region: AroK; COG0703 990317004843 Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464 990317004844 ADP binding site [chemical binding]; other site 990317004845 magnesium binding site [ion binding]; other site 990317004846 putative shikimate binding site; other site 990317004847 3-phosphoshikimate 1-carboxyvinyltransferase; Provisional; Region: PRK02427 990317004848 EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556 990317004849 hinge; other site 990317004850 active site 990317004851 GTP-binding protein LepA; Provisional; Region: PRK05433 990317004852 LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890 990317004853 G1 box; other site 990317004854 putative GEF interaction site [polypeptide binding]; other site 990317004855 GTP/Mg2+ binding site [chemical binding]; other site 990317004856 Switch I region; other site 990317004857 G2 box; other site 990317004858 G3 box; other site 990317004859 Switch II region; other site 990317004860 G4 box; other site 990317004861 G5 box; other site 990317004862 lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699 990317004863 lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane. LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709 990317004864 GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421 990317004865 Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413 990317004866 active site 990317004867 multimer interface [polypeptide binding]; other site 990317004868 Uncharacterized protein family (UPF0150); Region: UPF0150; pfam03681 990317004869 YcfA-like protein; Region: YcfA; pfam07927 990317004870 CRISPR/Cas system-associated protein Csn2; Region: Csn2; cd09758 990317004871 CRISPR type II-A/NMEMI-associated protein Csn2; Region: cas_Csn2; TIGR01866 990317004872 tetramer interface [polypeptide binding]; other site 990317004873 putative DNA binding site [nucleotide binding]; other site 990317004874 Ca binding site [ion binding]; other site 990317004875 Ca binding site [ion binding]; other site 990317004876 CRISPR/Cas system-associated protein Cas2; Region: Cas2_I_II_III; cd09638 990317004877 CRISPR/Cas system-associated protein Cas1; Region: Cas1_II; cd09720 990317004878 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cl00083 990317004879 CRISPR/Cas system-associated protein Cas9; Region: Csn1; cd09643 990317004880 Predicted membrane protein [Function unknown]; Region: COG4478 990317004881 HAD-superfamily subfamily IIA hydrolase, TIGR01457; Region: HAD-SF-IIA-hyp2 990317004882 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 990317004883 active site 990317004884 motif I; other site 990317004885 motif II; other site 990317004886 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 990317004887 Hydrolase of X-linked nucleoside diphosphate N terminal; Region: Nudix_N; pfam12535 990317004888 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_14; cd04672 990317004889 nudix motif; other site 990317004890 Acyl-ACP thioesterase; Region: Acyl-ACP_TE; pfam01643 990317004891 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 990317004892 active site 990317004893 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 990317004894 active site 2 [active] 990317004895 active site 1 [active] 990317004896 coproporphyrinogen III oxidase; Provisional; Region: PRK08599 990317004897 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 990317004898 FeS/SAM binding site; other site 990317004899 HemN C-terminal domain; Region: HemN_C; pfam06969 990317004900 phosphoglucosamine mutase; Provisional; Region: glmM; PRK14316 990317004901 GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802 990317004902 active site 990317004903 substrate binding site [chemical binding]; other site 990317004904 metal binding site [ion binding]; metal-binding site 990317004905 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4856 990317004906 YbbR-like protein; Region: YbbR; pfam07949 990317004907 Uncharacterized conserved protein [Function unknown]; Region: COG1624 990317004908 DisA bacterial checkpoint controller nucleotide-binding; Region: DisA_N; pfam02457 990317004909 UDP-N-acetylmuramyl tripeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurE; COG0769 990317004910 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 990317004911 Domain of unknown function (DUF1727); Region: DUF1727; pfam08353 990317004912 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyric Acid Synthase (CobQ); Region: GATase1_CobQ; cd01750 990317004913 catalytic triad [active] 990317004914 enolase; Provisional; Region: eno; PRK00077 990317004915 Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313 990317004916 dimer interface [polypeptide binding]; other site 990317004917 metal binding site [ion binding]; metal-binding site 990317004918 substrate binding pocket [chemical binding]; other site 990317004919 Protein of unknown function (DUF1694); Region: DUF1694; pfam07997 990317004920 Glycerate kinase [Carbohydrate transport and metabolism]; Region: COG1929 990317004921 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cd02883 990317004922 nudix motif; other site 990317004923 YSIRK type signal peptide; Region: YSIRK_signal; pfam04650 990317004924 Family 41 Carbohydrate-Binding Module from pullulanase-like enzymes; Region: CBM41_pullulanase; cd10315 990317004925 carbohydrate binding site [chemical binding]; other site 990317004926 Bacterial pullanase-associated domain; Region: PUD; pfam03714 990317004927 carbohydrate binding site [chemical binding]; other site 990317004928 Alpha amylase catalytic domain found in bacterial cyclomaltodextrinases and related proteins; Region: AmyAc_bac_CMD_like_2; cd11339 990317004929 Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366 990317004930 active site 990317004931 catalytic site [active] 990317004932 pullulanase, extracellular, Gram-positive; Region: pullulan_Gpos; TIGR02102 990317004933 Family 41 Carbohydrate-Binding Module from pullulanase-like enzymes; Region: CBM41_pullulanase; cd10315 990317004934 carbohydrate binding site [chemical binding]; other site 990317004935 Family 41 Carbohydrate-Binding Module from pullulanase-like enzymes; Region: CBM41_pullulanase; cd10315 990317004936 carbohydrate binding site [chemical binding]; other site 990317004937 Early set domain associated with the catalytic domain of pullulanase (also called dextrinase and alpha-dextrin endo-1,6-alpha glucosidase); Region: E_set_Pullulanase; cd02860 990317004938 Alpha amylase catalytic domain found in Pullulanase (also called dextrinase; alpha-dextrin endo-1,6-alpha glucosidase), limit dextrinase, and related proteins; Region: AmyAc_Pullulanase_LD-like; cd11341 990317004939 Ca binding site [ion binding]; other site 990317004940 active site 990317004941 catalytic site [active] 990317004942 LPXTG-motif cell wall anchor domain; Region: LPXTG_anchor; TIGR01167 990317004943 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in Escherichia coli phosphoribosyl-ATP pyrophosphohydrolase (HisIE or PRATP-PH) and its homologs; Region: NTP-PPase_HisIE_like; cd11534 990317004944 metal binding site [ion binding]; metal-binding site 990317004945 phosphoribosyl-AMP cyclohydrolase; Reviewed; Region: hisI; PRK00051 990317004946 The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731 990317004947 Histidine biosynthesis protein; Region: His_biosynth; pfam00977 990317004948 substrate binding site [chemical binding]; other site 990317004949 glutamase interaction surface [polypeptide binding]; other site 990317004950 HisA. Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1...; Region: HisA; cd04732 990317004951 phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; Region: TIGR00007 990317004952 catalytic residues [active] 990317004953 imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13141 990317004954 Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748 990317004955 putative active site [active] 990317004956 oxyanion strand; other site 990317004957 catalytic triad [active] 990317004958 Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cd07914 990317004959 putative active site pocket [active] 990317004960 4-fold oligomerization interface [polypeptide binding]; other site 990317004961 metal binding residues [ion binding]; metal-binding site 990317004962 3-fold/trimer interface [polypeptide binding]; other site 990317004963 phosphoserine phosphatase SerB; Region: serB; TIGR00338 990317004964 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 990317004965 motif II; other site 990317004966 Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572 990317004967 histidinol dehydrogenase; Region: hisD; TIGR00069 990317004968 dimerization interface [polypeptide binding]; other site 990317004969 NAD binding site [chemical binding]; other site 990317004970 product binding site; other site 990317004971 substrate binding site [chemical binding]; other site 990317004972 zinc binding site [ion binding]; other site 990317004973 catalytic residues [active] 990317004974 ATP phosphoribosyltransferase catalytic subunit; Reviewed; Region: hisG; PRK01686 990317004975 ATP phosphoribosyltransferase [Amino acid transport and metabolism]; Region: HisG; COG0040 990317004976 ATP phosphoribosyltransferase, regulatory subunit; Region: hisZ_biosyn_reg; TIGR00443 990317004977 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 990317004978 dimer interface [polypeptide binding]; other site 990317004979 motif 1; other site 990317004980 active site 990317004981 motif 2; other site 990317004982 motif 3; other site 990317004983 Histidinol-phosphate/aromatic aminotransferase and cobyric acid decarboxylase [Amino acid transport and metabolism]; Region: HisC; COG0079 990317004984 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 990317004985 pyridoxal 5'-phosphate binding site [chemical binding]; other site 990317004986 homodimer interface [polypeptide binding]; other site 990317004987 catalytic residue [active] 990317004988 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Provisional; Region: PRK07164 990317004989 Phosphorylase superfamily; Region: PNP_UDP_1; cl00303 990317004990 septation ring formation regulator EzrA; Provisional; Region: PRK04778 990317004991 DNA gyrase subunit B; Validated; Region: gyrB; PRK05644 990317004992 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 990317004993 Mg2+ binding site [ion binding]; other site 990317004994 G-X-G motif; other site 990317004995 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 990317004996 anchoring element; other site 990317004997 dimer interface [polypeptide binding]; other site 990317004998 ATP binding site [chemical binding]; other site 990317004999 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 990317005000 active site 990317005001 putative metal-binding site [ion binding]; other site 990317005002 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 990317005003 haloacid dehalogenase superfamily, subfamily IA, variant 1 with third motif having Dx(3-4)D or Dx(3-4)E; Region: HAD-SF-IA-v1; TIGR01549 990317005004 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 990317005005 motif II; other site 990317005006 Bacterial cell division membrane protein [Cell division and chromosome partitioning]; Region: FtsW; COG0772 990317005007 50S ribosomal protein L19; Provisional; Region: rplS; PRK05338 990317005008 CLC voltage-gated chloride channel. The ClC chloride channels catalyse the selective flow of Cl- ions across cell membranes, thereby regulating electrical excitation in skeletal muscle and the flow of salt and water across epithelial barriers. This...; Region: Voltage_gated_ClC; cl02915 990317005009 Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038 990317005010 Cl- selectivity filter; other site 990317005011 Cl- binding residues [ion binding]; other site 990317005012 pore gating glutamate residue; other site 990317005013 dimer interface [polypeptide binding]; other site 990317005014 hypothetical protein; Provisional; Region: PRK07248 990317005015 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 990317005016 cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814; cl03223 990317005017 FeS assembly protein SufB; Region: sufB; TIGR01980 990317005018 flavodoxin; Validated; Region: PRK07308 990317005019 Adenosine deaminase [Nucleotide transport and metabolism]; Region: Add; COG1816 990317005020 Adenosine deaminase (ADA) is a monomeric zinc dependent enzyme which catalyzes the irreversible hydrolytic deamination of both adenosine, as well as desoxyadenosine, to ammonia and inosine or desoxyinosine, respectively. ADA plays an important role in...; Region: ADA; cd01320 990317005021 active site 990317005022 purine riboside binding site [chemical binding]; other site 990317005023 asparaginyl-tRNA synthetase; Validated; Region: asnC; PRK03932 990317005024 AsnRS_cyto_like_N: N-terminal, anticodon recognition domain of the type found in human and Saccharomyces cerevisiae cytoplasmic asparaginyl-tRNA synthetase (AsnRS), in Brugia malayai AsnRs and, in various putative bacterial AsnRSs. This domain is a...; Region: AsnRS_cyto_like_N; cd04323 990317005025 putative dimer interface [polypeptide binding]; other site 990317005026 putative anticodon binding site; other site 990317005027 Asx tRNA synthetase (AspRS/AsnRS) class II core domain. Assignment to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs in the core domain. This family includes AsnRS as well as...; Region: AsxRS_core; cd00776 990317005028 homodimer interface [polypeptide binding]; other site 990317005029 motif 1; other site 990317005030 motif 2; other site 990317005031 active site 990317005032 motif 3; other site 990317005033 Chagasin family peptidase inhibitor I42; Region: Inhibitor_I42; pfam09394 990317005034 aspartate aminotransferase; Provisional; Region: PRK05764 990317005035 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 990317005036 pyridoxal 5'-phosphate binding site [chemical binding]; other site 990317005037 homodimer interface [polypeptide binding]; other site 990317005038 catalytic residue [active] 990317005039 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5353 990317005040 bifunctional ATP-dependent DNA helicase/DNA polymerase III subunit epsilon; Validated; Region: PRK07246 990317005041 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 990317005042 active site 990317005043 catalytic site [active] 990317005044 substrate binding site [chemical binding]; other site 990317005045 CRISPR/Cas system-associated DinG family helicase Csf4; Region: Csf4_U; cl17460 990317005046 Helicase C-terminal domain; Region: Helicase_C_2; pfam13307 990317005047 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819 990317005048 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4947 990317005049 Putative esterase; Region: Esterase; pfam00756 990317005050 ATP-grasp domain; Region: ATP-grasp_4; pfam13535 990317005051 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 990317005052 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 990317005053 Cell division protein [Cell division and chromosome partitioning]; Region: FtsX; COG2177 990317005054 cell division ABC transporter subunit FtsX; Provisional; Region: ftsX; PRK11026 990317005055 Predicted ATPase involved in cell division [Cell division and chromosome partitioning]; Region: FtsE; COG2884 990317005056 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 990317005057 Walker A/P-loop; other site 990317005058 ATP binding site [chemical binding]; other site 990317005059 Q-loop/lid; other site 990317005060 ABC transporter signature motif; other site 990317005061 Walker B; other site 990317005062 D-loop; other site 990317005063 H-loop/switch region; other site 990317005064 peptide chain release factor 2; Validated; Region: prfB; PRK00578 990317005065 PCRF domain; Region: PCRF; pfam03462 990317005066 RF-1 domain; Region: RF-1; pfam00472 990317005067 Predicted phosphatase/phosphohexomutase [General function prediction only]; Region: COG0637 990317005068 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 990317005069 motif II; other site 990317005070 putative phosphoesterase; Region: acc_ester; TIGR03729 990317005071 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 990317005072 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 990317005073 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; pfam00690 990317005074 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 990317005075 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 990317005076 haloacid dehalogenase-like hydrolase; Region: HAD; pfam12710 990317005077 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 990317005078 Domain of unknown function (DUF1934); Region: DUF1934; pfam09148 990317005079 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 990317005080 HD superfamily phosphohydrolases [General function prediction only]; Region: COG1078 990317005081 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 990317005082 Zn2+ binding site [ion binding]; other site 990317005083 Mg2+ binding site [ion binding]; other site 990317005084 sugar phosphate phosphatase; Provisional; Region: PRK10513 990317005085 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 990317005086 active site 990317005087 motif I; other site 990317005088 motif II; other site 990317005089 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 990317005090 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 990317005091 FemAB family; Region: FemAB; pfam02388 990317005092 FemAB family; Region: FemAB; pfam02388 990317005093 U3 small nucleolar ribonucleoprotein component [Translation, ribosomal structure and biogenesis]; Region: Mpp10; COG5384 990317005094 Acetyltransferase (GNAT) domain; Region: Acetyltransf_6; pfam13480 990317005095 triosephosphate isomerase; Provisional; Region: PRK14567 990317005096 Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311 990317005097 substrate binding site [chemical binding]; other site 990317005098 dimer interface [polypeptide binding]; other site 990317005099 catalytic triad [active] 990317005100 elongation factor Tu; Reviewed; Region: PRK00049 990317005101 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 990317005102 G1 box; other site 990317005103 GEF interaction site [polypeptide binding]; other site 990317005104 GTP/Mg2+ binding site [chemical binding]; other site 990317005105 Switch I region; other site 990317005106 G2 box; other site 990317005107 G3 box; other site 990317005108 Switch II region; other site 990317005109 G4 box; other site 990317005110 G5 box; other site 990317005111 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 990317005112 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 990317005113 Antibiotic Binding Site [chemical binding]; other site 990317005114 Sigma factor regulator N-terminal; Region: Sigma_reg_N; pfam13800 990317005115 Sigma factor regulator C-terminal; Region: Sigma_reg_C; pfam13791 990317005116 RNA polymerase sigma factor, SigM family; Region: SigM_subfam; TIGR02950 990317005117 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 990317005118 DNA binding residues [nucleotide binding] 990317005119 Bacterial cell division membrane protein [Cell division and chromosome partitioning]; Region: FtsW; COG0772 990317005120 phosphoenolpyruvate carboxylase; Reviewed; Region: PRK00009 990317005121 Phosphoenolpyruvate carboxylase [Energy production and conversion]; Region: Ppc; COG2352 990317005122 Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins); Region: GluZincin; cl14813 990317005123 Zn binding site [ion binding]; other site 990317005124 Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins); Region: GluZincin; cl14813 990317005125 Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per...; Region: GSH_Peroxidase; cd00340 990317005126 catalytic residues [active] 990317005127 dimer interface [polypeptide binding]; other site 990317005128 Lyzozyme M1 (1,4-beta-N-acetylmuramidase) [Cell envelope biogenesis, outer membrane]; Region: Acm; COG3757 990317005129 PlyB is a bacteriophage endolysin that displays potent lytic activity toward Bacillus anthracis. PlyB has an N-terminal glycosyl hydrolase family 25 (GH25) catalytic domain and a C-terminal bacterial SH3-like domain, SH3b. Both domains are required for...; Region: GH25_PlyB-like; cd06523 990317005130 active site 990317005131 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 990317005132 amidase catalytic site [active] 990317005133 Zn binding residues [ion binding]; other site 990317005134 substrate binding site [chemical binding]; other site 990317005135 This CD includes cysteinyl-tRNA(Pro) deacylases from Haemophilus influenzae and Escherichia coli and other related bacterial proteins. These trans-acting, single-domain proteins are homologs of ProX and also the cis-acting prolyl-tRNA synthetase (ProRS)...; Region: YbaK_deacylase; cd00002 990317005136 putative deacylase active site [active] 990317005137 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 990317005138 catalytic core [active] 990317005139 Predicted hydrolase (HAD superfamily) [General function prediction only]; Region: COG1011 990317005140 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 990317005141 motif II; other site 990317005142 lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484 990317005143 LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322 990317005144 dimer interface [polypeptide binding]; other site 990317005145 putative anticodon binding site; other site 990317005146 Lys_tRNA synthetase (LysRS) class II core domain. Class II LysRS is a dimer which attaches a lysine to the 3' OH group of ribose of the appropriate tRNA. Its assignment to class II aaRS is based upon its structure and the presence of three...; Region: LysRS_core; cd00775 990317005147 motif 1; other site 990317005148 active site 990317005149 motif 2; other site 990317005150 motif 3; other site 990317005151 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 990317005152 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 990317005153 Transcriptional regulator C-terminal region; Region: TetR_C_8; pfam14278 990317005154 Predicted hydrolase (HAD superfamily) [General function prediction only]; Region: COG1011 990317005155 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 990317005156 active site 990317005157 motif I; other site 990317005158 motif II; other site 990317005159 BioY family; Region: BioY; pfam02632 990317005160 Uncharacterized protein conserved in bacteria (DUF2128); Region: DUF2128; pfam09901 990317005161 Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826 990317005162 Peptidase family U32; Region: Peptidase_U32; pfam01136 990317005163 Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826 990317005164 Phosphoribosyltransferase (PRTase) type II; This family contains two enzymes that play an important role in NAD production by either allowing quinolinic acid (QA) , quinolinate phosphoribosyl transferase (QAPRTase), or nicotinic acid (NA), nicotinate...; Region: PRTase_typeII; cl17275 990317005165 Peptidase family U32; Region: Peptidase_U32; pfam01136 990317005166 Protein of unknown function (DUF3270); Region: DUF3270; pfam11674 990317005167 Uncharacterized protein containing a divergent version of the methyl-accepting chemotaxis-like domain [General function prediction only]; Region: COG4768 990317005168 Prolipoprotein diacylglyceryl transferase; Region: LGT; pfam01790 990317005169 HPr kinase/phosphorylase; Provisional; Region: PRK05428 990317005170 HPr Serine kinase N terminus; Region: Hpr_kinase_N; pfam02603 990317005171 HprK/P, the bifunctional histidine-containing protein kinase/phosphatase, controls the phosphorylation state of the phosphocarrier protein HPr and regulates the utilization of carbon sources by gram-positive bacteria. It catalyzes both the ATP-dependent...; Region: HprK_C; cd01918 990317005172 Hpr binding site; other site 990317005173 active site 990317005174 homohexamer subunit interaction site [polypeptide binding]; other site 990317005175 PspC domain; Region: PspC; pfam04024 990317005176 hypothetical protein; Provisional; Region: PRK04351 990317005177 Zn-dependent metalloprotease, SprT family [General function prediction only]; Region: SprT; COG3091 990317005178 Transcriptional accessory protein [Transcription]; Region: Tex; COG2183 990317005179 Tex-like protein N-terminal domain; Region: Tex_N; pfam09371 990317005180 Likely ribonuclease with RNase H fold; Region: YqgFc; smart00732 990317005181 S1_Tex: The C-terminal S1 domain of a transcription accessory factor called Tex, which has been characterized in Bordetella pertussis and Pseudomonas aeruginosa. The tex gene is essential in Bortella pertusis and is named for its role in toxin expression; Region: S1_Tex; cd05685 990317005182 RNA binding site [nucleotide binding]; other site 990317005183 Predicted permeases [General function prediction only]; Region: COG0701 990317005184 Predicted membrane protein [Function unknown]; Region: COG3689 990317005185 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 990317005186 Medium chain dehydrogenases/reductase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR2; cd08268 990317005187 putative NAD(P) binding site [chemical binding]; other site 990317005188 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 990317005189 Helix-Turn-Helix DNA binding domain of the MerR-like transcription regulators YyaN and YraB; Region: HTH_YyaN; cd01109 990317005190 DNA binding residues [nucleotide binding] 990317005191 putative dimer interface [polypeptide binding]; other site 990317005192 signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416 990317005193 SRP54-type protein, helical bundle domain; Region: SRP54_N; pfam02881 990317005194 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 990317005195 P loop; other site 990317005196 GTP binding site [chemical binding]; other site 990317005197 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 990317005198 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 990317005199 active site 990317005200 motif I; other site 990317005201 motif II; other site 990317005202 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 990317005203 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cl17915 990317005204 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 990317005205 active site 990317005206 motif I; other site 990317005207 motif II; other site 990317005208 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 990317005209 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 990317005210 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 990317005211 Walker A/P-loop; other site 990317005212 ATP binding site [chemical binding]; other site 990317005213 Q-loop/lid; other site 990317005214 SMC proteins Flexible Hinge Domain; Region: SMC_hinge; smart00968 990317005215 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 990317005216 ABC transporter signature motif; other site 990317005217 Walker B; other site 990317005218 D-loop; other site 990317005219 H-loop/switch region; other site 990317005220 ribonuclease III; Reviewed; Region: rnc; PRK00102 990317005221 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 990317005222 dimerization interface [polypeptide binding]; other site 990317005223 active site 990317005224 metal binding site [ion binding]; metal-binding site 990317005225 Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048 990317005226 dsRNA binding site [nucleotide binding]; other site 990317005227 Metal-dependent hydrolases of the beta-lactamase superfamily I [General function prediction only]; Region: PhnP; COG1235 990317005228 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 990317005229 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: VicK; COG5002 990317005230 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 990317005231 putative active site [active] 990317005232 heme pocket [chemical binding]; other site 990317005233 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 990317005234 dimer interface [polypeptide binding]; other site 990317005235 phosphorylation site [posttranslational modification] 990317005236 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 990317005237 ATP binding site [chemical binding]; other site 990317005238 Mg2+ binding site [ion binding]; other site 990317005239 G-X-G motif; other site 990317005240 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 990317005241 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 990317005242 active site 990317005243 phosphorylation site [posttranslational modification] 990317005244 intermolecular recognition site; other site 990317005245 dimerization interface [polypeptide binding]; other site 990317005246 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 990317005247 DNA binding site [nucleotide binding] 990317005248 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 990317005249 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 990317005250 Walker A/P-loop; other site 990317005251 ATP binding site [chemical binding]; other site 990317005252 Q-loop/lid; other site 990317005253 ABC transporter signature motif; other site 990317005254 Walker B; other site 990317005255 D-loop; other site 990317005256 H-loop/switch region; other site 990317005257 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 990317005258 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 990317005259 substrate binding pocket [chemical binding]; other site 990317005260 membrane-bound complex binding site; other site 990317005261 hinge residues; other site 990317005262 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 990317005263 dimer interface [polypeptide binding]; other site 990317005264 conserved gate region; other site 990317005265 putative PBP binding loops; other site 990317005266 ABC-ATPase subunit interface; other site 990317005267 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 990317005268 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 990317005269 dimer interface [polypeptide binding]; other site 990317005270 conserved gate region; other site 990317005271 putative PBP binding loops; other site 990317005272 ABC-ATPase subunit interface; other site 990317005273 Uncharacterized conserved protein [Function unknown]; Region: COG0398 990317005274 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 990317005275 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 990317005276 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 990317005277 dimer interface [polypeptide binding]; other site 990317005278 phosphorylation site [posttranslational modification] 990317005279 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 990317005280 ATP binding site [chemical binding]; other site 990317005281 Mg2+ binding site [ion binding]; other site 990317005282 G-X-G motif; other site 990317005283 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 990317005284 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 990317005285 active site 990317005286 phosphorylation site [posttranslational modification] 990317005287 intermolecular recognition site; other site 990317005288 dimerization interface [polypeptide binding]; other site 990317005289 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 990317005290 DNA binding site [nucleotide binding] 990317005291 Protein of unknown function (DUF3114); Region: DUF3114; pfam11311 990317005292 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3041 990317005293 RelB antitoxin; Region: RelB; cl01171 990317005294 probable dihydroxyacetone kinase regulator; Region: DHAK_reg; TIGR02366 990317005295 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 990317005296 myosin-cross-reactive antigen; Provisional; Region: PRK13977 990317005297 Sortase C (SrtC) or subfamily-3 sortases are membrane cysteine transpeptidases found in Gram-positive bacteria that anchor surface proteins to peptidoglycans of the bacterial cell wall envelope. This involves a transpeptidation reaction in which the...; Region: Sortase_C_3; cd05827 990317005298 active site 990317005299 catalytic site [active] 990317005300 fimbrial isopeptide formation D2 domain; Region: RrgB_K2N_iso_D2; TIGR04226 990317005301 Cna protein B-type domain; Region: Cna_B; pfam05738 990317005302 TQXA domain; Region: TQXA_dom; TIGR03934 990317005303 Repeat unit of collagen-binding protein domain B; Region: CollagenBindB; cd00222 990317005304 domain interaction interfaces [polypeptide binding]; other site 990317005305 Repeat unit of collagen-binding protein domain B; Region: CollagenBindB; cd00222 990317005306 domain interaction interfaces [polypeptide binding]; other site 990317005307 Repeat unit of collagen-binding protein domain B; Region: CollagenBindB; cd00222 990317005308 domain interaction interfaces [polypeptide binding]; other site 990317005309 Repeat unit of collagen-binding protein domain B; Region: CollagenBindB; cd00222 990317005310 domain interaction interfaces [polypeptide binding]; other site 990317005311 LPXTG-motif cell wall anchor domain; Region: LPXTG_anchor; TIGR01167 990317005312 LXG domain of WXG superfamily; Region: LXG; pfam04740 990317005313 type VII secretion effector, SACOL2603 family; Region: T7SS_SACOL2603; TIGR04197 990317005314 Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific...; Region: RICIN; cd00161 990317005315 Ricin-type beta-trefoil lectin domain; Region: Ricin_B_lectin; pfam00652 990317005316 putative sugar binding sites [chemical binding]; other site 990317005317 Q-X-W motif; other site 990317005318 threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK00413 990317005319 TGS _ThrRS_N: ThrRS (threonyl-tRNA Synthetase) is a class II tRNA synthetase that couples threonine to its cognate tRNA. In addition to its catalytic and anticodon-binding domains, ThrRS has an N-terminal TGS domain, named after the ThrRS, GTPase, and...; Region: TGS_ThrRS_N; cd01667 990317005320 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 990317005321 Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771 990317005322 active site 990317005323 dimer interface [polypeptide binding]; other site 990317005324 motif 1; other site 990317005325 motif 2; other site 990317005326 motif 3; other site 990317005327 ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860 990317005328 anticodon binding site; other site 990317005329 This family is most closely related to the GT1 family of glycosyltransferases. UDP-glucose-diacylglycerol glucosyltransferase (UGDG; also known as 1,2-diacylglycerol 3-glucosyltransferase) catalyzes the transfer of glucose from UDP-glucose to 1; Region: GT1_UGDG_like; cd03817 990317005330 Glycosyltransferase Family 4; Region: Glyco_transf_4; pfam13439 990317005331 putative ADP-binding pocket [chemical binding]; other site 990317005332 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 990317005333 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 990317005334 catabolite control protein A; Region: ccpA; TIGR01481 990317005335 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 990317005336 DNA binding site [nucleotide binding] 990317005337 domain linker motif; other site 990317005338 Ligand-binding domain of the catabolite control protein A (CcpA), which functions as the major transcriptional regulator of carbon catabolite repression/regulation; Region: PBP1_CcpA_like; cd06298 990317005339 dimerization interface [polypeptide binding]; other site 990317005340 effector binding site; other site 990317005341 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 990317005342 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 990317005343 Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092 990317005344 active site 990317005345 Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism]; Region: EmrE; COG2076 990317005346 NADH pyrophosphatase, a member of the Nudix hydrolase superfamily, catalyzes the cleavage of NADH into reduced nicotinamide mononucleotide (NMNH) and AMP. Like other members of the Nudix family, it requires a divalent cation, such as Mg2+ or Mn2+, for...; Region: NADH_pyrophosphatase; cd03429 990317005347 putative NADH binding site [chemical binding]; other site 990317005348 putative active site [active] 990317005349 nudix motif; other site 990317005350 putative metal binding site [ion binding]; other site 990317005351 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 990317005352 Sel1-like repeats; Region: SEL1; smart00671 990317005353 LPXTG-motif cell wall anchor domain; Region: LPXTG_anchor; TIGR01167 990317005354 PTS system, beta-glucoside-specific IIABC component; Region: PTS-II-ABC-beta; TIGR01995 990317005355 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 990317005356 active site turn [active] 990317005357 phosphorylation site [posttranslational modification] 990317005358 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 990317005359 Phosphotransferase system IIA components [Carbohydrate transport and metabolism]; Region: NagE; COG2190 990317005360 HPr interaction site; other site 990317005361 glycerol kinase (GK) interaction site [polypeptide binding]; other site 990317005362 active site 990317005363 phosphorylation site [posttranslational modification] 990317005364 Neutral/alkaline non-lysosomal ceramidase; Region: Ceramidase_alk; cl04712 990317005365 Neutral/alkaline non-lysosomal ceramidase; Region: Ceramidase_alk; cl04712 990317005366 Amidohydrolase; Region: Amidohydro_2; pfam04909 990317005367 Transcriptional regulator [Transcription]; Region: LysR; COG0583 990317005368 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 990317005369 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 990317005370 dimerization interface [polypeptide binding]; other site 990317005371 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Bacillus subtilis yoeA; Region: MATE_yoeA_like; cd13138 990317005372 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 990317005373 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028 990317005374 classical (c) SDRs; Region: SDR_c; cd05233 990317005375 NAD(P) binding site [chemical binding]; other site 990317005376 active site 990317005377 beta-phosphoglucomutase; Region: bPGM; TIGR01990 990317005378 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 990317005379 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 990317005380 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; cl07971 990317005381 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 990317005382 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; cl07971 990317005383 Poly(3-hydroxybutyrate) depolymerase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: LpqC; COG3509 990317005384 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 990317005385 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 990317005386 active site 990317005387 catalytic tetrad [active] 990317005388 MFS/sugar transport protein; Region: MFS_2; pfam13347 990317005389 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 990317005390 Amidohydrolase; Region: Amidohydro_2; pfam04909 990317005391 uncharacterized YdjC-like family proteins from bacteria; Region: YdjC_like_1; cd10805 990317005392 putative active site [active] 990317005393 YdjC motif; other site 990317005394 Mg binding site [ion binding]; other site 990317005395 putative homodimer interface [polypeptide binding]; other site 990317005396 PTS system, sucrose-specific IIBC component; Region: PTS-II-BC-sucr; TIGR01996 990317005397 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 990317005398 active site turn [active] 990317005399 phosphorylation site [posttranslational modification] 990317005400 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 990317005401 transcriptional antiterminator BglG; Provisional; Region: PRK09772 990317005402 CAT RNA binding domain; Region: CAT_RBD; smart01061 990317005403 PRD domain; Region: PRD; pfam00874 990317005404 PRD domain; Region: PRD; pfam00874 990317005405 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 990317005406 Sel1-like repeats; Region: SEL1; smart00671 990317005407 PTS system, sucrose-specific IIBC component; Region: PTS-II-BC-sucr; TIGR01996 990317005408 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 990317005409 active site turn [active] 990317005410 phosphorylation site [posttranslational modification] 990317005411 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 990317005412 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 990317005413 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 990317005414 SIS domain. SIS (Sugar ISomerase) domains are found in many phosphosugar isomerases and phosphosugar binding proteins. SIS domains are also found in proteins that regulate the expression of genes involved in synthesis of phosphosugars; Region: SIS; cl00389 990317005415 3-polyprenyl-4-hydroxybenzoate decarboxylase [Coenzyme metabolism]; Region: UbiX; COG0163 990317005416 Flavoprotein; Region: Flavoprotein; pfam02441 990317005417 3-octaprenyl-4-hydroxybenzoate carboxy-lyase; Region: UbiD; pfam01977 990317005418 Transcriptional regulator [Transcription]; Region: LysR; COG0583 990317005419 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 990317005420 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 990317005421 dimerization interface [polypeptide binding]; other site 990317005422 Protein of unknown function (DUF554); Region: DUF554; pfam04474 990317005423 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 990317005424 MarR family; Region: MarR_2; pfam12802 990317005425 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 990317005426 hydrophobic ligand binding site; other site 990317005427 NAD(P)H:FMN oxidoreductase family. This domain catalyzes the reduction of flavin, nitrocompound, quinones and azo compounds using NADH or NADPH as an electron donor. The enzyme is a homodimer, and each monomer binds a FMN as co-factor. This family...; Region: NfsB_like_nitroreductase; cd02149 990317005428 dimer interface [polypeptide binding]; other site 990317005429 FMN binding site [chemical binding]; other site 990317005430 Glycosyl hydrolase family 1; Region: Glyco_hydro_1; cl01046 990317005431 beta-galactosidase; Region: BGL; TIGR03356 990317005432 PTS system, beta-glucoside-specific IIABC component; Region: PTS-II-ABC-beta; TIGR01995 990317005433 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 990317005434 active site turn [active] 990317005435 phosphorylation site [posttranslational modification] 990317005436 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 990317005437 Phosphotransferase system IIA components [Carbohydrate transport and metabolism]; Region: NagE; COG2190 990317005438 HPr interaction site; other site 990317005439 glycerol kinase (GK) interaction site [polypeptide binding]; other site 990317005440 active site 990317005441 phosphorylation site [posttranslational modification] 990317005442 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 990317005443 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 990317005444 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 990317005445 putative active site [active] 990317005446 Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294 990317005447 SmpB-tmRNA interface; other site 990317005448 ribonuclease R; Region: RNase_R; TIGR02063 990317005449 Ribonuclease B OB domain; Region: OB_RNB; pfam08206 990317005450 RNB domain; Region: RNB; pfam00773 990317005451 S1_RNase_R: RNase R C-terminal S1 domain. RNase R is a processive 3' to 5' exoribonuclease, which is a homolog of RNase II. RNase R degrades RNA with secondary structure having a 3' overhang of at least 7 nucleotides. RNase R and PNPase...; Region: S1_RNase_R; cd04471 990317005452 RNA binding site [nucleotide binding]; other site 990317005453 preprotein translocase subunit SecG; Reviewed; Region: secG; PRK06870 990317005454 drug efflux system protein MdtG; Provisional; Region: PRK09874 990317005455 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 990317005456 putative substrate translocation pore; other site 990317005457 Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022 990317005458 Dephospho-CoA kinase [Coenzyme metabolism]; Region: CoaE; COG0237 990317005459 CoA-binding site [chemical binding]; other site 990317005460 formamidopyrimidine/5-formyluracil/ 5-hydroxymethyluracil DNA glycosylase; Validated; Region: PRK01103 990317005461 N-terminal domain of Escherichia coli Fpg1/MutM and related bacterial DNA glycosylases; Region: EcFpg-like_N; cd08966 990317005462 DNA binding site [nucleotide binding] 990317005463 catalytic residue [active] 990317005464 H2TH interface [polypeptide binding]; other site 990317005465 putative catalytic residues [active] 990317005466 turnover-facilitating residue; other site 990317005467 intercalation triad [nucleotide binding]; other site 990317005468 8OG recognition residue [nucleotide binding]; other site 990317005469 putative reading head residues; other site 990317005470 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 990317005471 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 990317005472 GTPase Era; Reviewed; Region: era; PRK00089 990317005473 E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163 990317005474 G1 box; other site 990317005475 GTP/Mg2+ binding site [chemical binding]; other site 990317005476 Switch I region; other site 990317005477 G2 box; other site 990317005478 Switch II region; other site 990317005479 G3 box; other site 990317005480 G4 box; other site 990317005481 G5 box; other site 990317005482 KH domain; Region: KH_2; pfam07650 990317005483 Diacylglycerol kinase [Cell envelope biogenesis, outer membrane]; Region: DgkA; COG0818 990317005484 metal-binding heat shock protein; Provisional; Region: PRK00016 990317005485 Alpha amylase catalytic domain found in bacterial Alpha-amylases (also called 1,4-alpha-D-glucan-4-glucanohydrolase); Region: AmyAc_bac1_AmyA; cd11315 990317005486 Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366 990317005487 active site 990317005488 Ca binding site [ion binding]; other site 990317005489 catalytic site [active] 990317005490 Aamy_C domain; Region: Aamy_C; smart00632 990317005491 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 990317005492 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 990317005493 Protein of unknown function (DUF3810); Region: DUF3810; pfam12725 990317005494 Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702 990317005495 PhoH-like protein; Region: PhoH; pfam02562 990317005496 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 990317005497 Major Facilitator Superfamily; Region: MFS_1; pfam07690 990317005498 putative substrate translocation pore; other site 990317005499 hypothetical protein; Provisional; Region: PRK13672 990317005500 methionine sulfoxide reductase A; Provisional; Region: PRK14054 990317005501 Predicted RNA-bindining protein (contains S1 and HTH domains) [General function prediction only]; Region: COG2996 990317005502 S1 domain; Region: S1_2; pfam13509 990317005503 Ribosomal protein S1-like RNA-binding domain; Region: S1; smart00316 990317005504 ribosome recycling factor; Reviewed; Region: frr; PRK00083 990317005505 Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation. Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520 990317005506 hinge region; other site 990317005507 UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254 990317005508 putative nucleotide binding site [chemical binding]; other site 990317005509 uridine monophosphate binding site [chemical binding]; other site 990317005510 homohexameric interface [polypeptide binding]; other site 990317005511 Ribosomal protein L1. The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA. In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403 990317005512 mRNA/rRNA interface [nucleotide binding]; other site 990317005513 50S ribosomal protein L11; Validated; Region: rplK; PRK00140 990317005514 Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349 990317005515 23S rRNA interface [nucleotide binding]; other site 990317005516 L7/L12 interface [polypeptide binding]; other site 990317005517 putative thiostrepton binding site; other site 990317005518 L25 interface [polypeptide binding]; other site 990317005519 Protein of unknown function (DUF3397); Region: DUF3397; pfam11877 990317005520 DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674 990317005521 4-hydroxybenzoate polyprenyltransferase and related prenyltransferases [Coenzyme metabolism]; Region: UbiA; cl00337 990317005522 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 990317005523 Ftsk gamma domain; Region: Ftsk_gamma; pfam09397 990317005524 Peptidyl-prolyl cis-trans isomerase (rotamase) - cyclophilin family [Posttranslational modification, protein turnover, chaperones]; Region: PpiB; COG0652 990317005525 active site 990317005526 Mn-dependent transcriptional regulator [Transcription]; Region: TroR; COG1321 990317005527 Iron dependent repressor, N-terminal DNA binding domain; Region: Fe_dep_repress; pfam01325 990317005528 Iron dependent repressor, metal binding and dimerisation domain; Region: Fe_dep_repr_C; pfam02742 990317005529 FeoA domain; Region: FeoA; pfam04023 990317005530 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Validated; Region: PRK05584 990317005531 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Region: MTA/SAH-Nsdase; TIGR01704 990317005532 DNA-directed RNA polymerase subunit B'; Validated; Region: PRK07225 990317005533 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 990317005534 dimer interface [polypeptide binding]; other site 990317005535 ADP-ribose binding site [chemical binding]; other site 990317005536 active site 990317005537 nudix motif; other site 990317005538 metal binding site [ion binding]; metal-binding site 990317005539 bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase; Provisional; Region: glmU; PRK14354 990317005540 N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540 990317005541 Substrate binding site; other site 990317005542 Mg++ binding site; other site 990317005543 N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353 990317005544 active site 990317005545 substrate binding site [chemical binding]; other site 990317005546 CoA binding site [chemical binding]; other site 990317005547 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 990317005548 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 990317005549 ASC-1 homology domain, subfamily similar to Enterococcus faecalis Ef3133. The ASCH domain, a small beta-barrel domain found in all three kingdoms of life, resembles the RNA-binding PUA domain and may also interact with RNA. ASCH has been proposed to...; Region: ASCH_Ef3133_like; cd06553 990317005550 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK06550 990317005551 classical (c) SDRs; Region: SDR_c; cd05233 990317005552 NAD(P) binding site [chemical binding]; other site 990317005553 active site 990317005554 Protein of unknown function (DUF2829); Region: DUF2829; pfam11195 990317005555 hypothetical protein; Validated; Region: PRK07668 990317005556 Predicted transcriptional regulators [Transcription]; Region: COG1695 990317005557 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 990317005558 FemAB family; Region: FemAB; pfam02388 990317005559 methionyl-tRNA synthetase; Reviewed; Region: PRK12267 990317005560 catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814 990317005561 active site 990317005562 HIGH motif; other site 990317005563 KMSKS motif; other site 990317005564 Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957 990317005565 tRNA binding surface [nucleotide binding]; other site 990317005566 anticodon binding site; other site 990317005567 tRNA-binding-domain-containing Escherichia coli methionyl-tRNA synthetase (EcMetRS)-like proteins. This family includes EcMetRS and Aquifex aeolicus Trbp111 (AaTrbp111). This domain has general tRNA binding properties. MetRS aminoacylates methionine...; Region: tRNA_bind_EcMetRS_like; cd02800 990317005568 dimer interface [polypeptide binding]; other site 990317005569 putative tRNA-binding site [nucleotide binding]; other site 990317005570 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 990317005571 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Thermotoga marina NorM; Region: MATE_NorM_like; cd13137 990317005572 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 990317005573 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 990317005574 Human Ape1-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: Ape1-like_AP-endo; cd09087 990317005575 active site 990317005576 putative catalytic site [active] 990317005577 DNA binding site [nucleotide binding] 990317005578 putative phosphate binding site [ion binding]; other site 990317005579 metal binding site A [ion binding]; metal-binding site 990317005580 AP binding site [nucleotide binding]; other site 990317005581 metal binding site B [ion binding]; metal-binding site 990317005582 Major Facilitator Superfamily; Region: MFS_1; pfam07690 990317005583 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 990317005584 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 990317005585 SnoaL-like domain; Region: SnoaL_3; pfam13474 990317005586 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 990317005587 active site 990317005588 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 990317005589 catalytic tetrad [active] 990317005590 short chain dehydrogenase; Provisional; Region: PRK06940 990317005591 classical (c) SDRs; Region: SDR_c; cd05233 990317005592 NAD(P) binding site [chemical binding]; other site 990317005593 active site 990317005594 Transcriptional regulator [Transcription]; Region: LysR; COG0583 990317005595 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 990317005596 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 990317005597 dimerization interface [polypeptide binding]; other site 990317005598 Arsenate Reductase (ArsC) family, unknown subfamily; uncharacterized proteins containing a CXXC motif with similarity to thioredoxin (TRX)-fold arsenic reductases, ArsC. Proteins containing a redox active CXXC motif like TRX and glutaredoxin (GRX)...; Region: ArsC_like; cd03036 990317005599 ArsC family; Region: ArsC; pfam03960 990317005600 putative ArsC-like catalytic residues; other site 990317005601 putative TRX-like catalytic residues [active] 990317005602 Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350 990317005603 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 990317005604 DNA binding site [nucleotide binding] 990317005605 active site 990317005606 Putative D-3-Phosphoglycerate Dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_like_3; cd12174 990317005607 D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain; Region: 2-Hacid_dh; pfam00389 990317005608 putative ligand binding site [chemical binding]; other site 990317005609 putative NAD binding site [chemical binding]; other site 990317005610 putative catalytic site [active] 990317005611 C-terminal ACT (regulatory) domain of D-3-Phosphoglycerate Dehydrogenase (3PGDH) found in fungi and bacteria; Region: ACT_3PGDH; cd04901 990317005612 L-serine binding site [chemical binding]; other site 990317005613 ACT domain interface; other site 990317005614 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 990317005615 3-phosphoserine/phosphohydroxythreonine aminotransferase; Provisional; Region: PRK05355 990317005616 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 990317005617 catalytic residue [active] 990317005618 Uncharacterized protein involved in copper resistance [Inorganic ion transport and metabolism]; Region: CutC; COG3142 990317005619 Nitrogen regulatory protein PII [Amino acid transport and metabolism]; Region: GlnK; COG0347 990317005620 Nitrogen regulatory protein P-II; Region: P-II; smart00938 990317005621 Ammonia permease [Inorganic ion transport and metabolism]; Region: AmtB; COG0004 990317005622 Predicted methyltransferases [General function prediction only]; Region: COG0313 990317005623 Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648 990317005624 putative SAM binding site [chemical binding]; other site 990317005625 putative homodimer interface [polypeptide binding]; other site 990317005626 DNA replication intiation control protein YabA; Reviewed; Region: PRK13169 990317005627 Uncharacterized homolog of PSP1 [Function unknown]; Region: COG1774 990317005628 DNA polymerase III subunit delta'; Validated; Region: PRK07276 990317005629 DNA polymerase III subunit delta'; Validated; Region: PRK08485 990317005630 thymidylate kinase; Validated; Region: tmk; PRK00698 990317005631 Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672 990317005632 TMP-binding site; other site 990317005633 ATP-binding site [chemical binding]; other site 990317005634 FOG: CBS domain [General function prediction only]; Region: COG0517 990317005635 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the acetoin utilization proteins in bacteria. Acetoin is a product of fermentative metabolism in many prokaryotic and eukaryotic microorganisms. They produce...; Region: CBS_pair_ACT_assoc2; cd04585 990317005636 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cd02116 990317005637 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 990317005638 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 990317005639 Walker A/P-loop; other site 990317005640 ATP binding site [chemical binding]; other site 990317005641 Q-loop/lid; other site 990317005642 ABC transporter signature motif; other site 990317005643 Walker B; other site 990317005644 D-loop; other site 990317005645 H-loop/switch region; other site 990317005646 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 990317005647 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 990317005648 Walker A/P-loop; other site 990317005649 ATP binding site [chemical binding]; other site 990317005650 Q-loop/lid; other site 990317005651 ABC transporter signature motif; other site 990317005652 Walker B; other site 990317005653 D-loop; other site 990317005654 H-loop/switch region; other site 990317005655 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 990317005656 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 990317005657 TM-ABC transporter signature motif; other site 990317005658 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 990317005659 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 990317005660 TM-ABC transporter signature motif; other site 990317005661 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 990317005662 Type I periplasmic ligand-binding domain of uncharacterized ABC (Atpase Binding Cassette)-type active transport systems that are predicted to be involved in uptake of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_ligand_binding_like_12; cd06347 990317005663 putative ligand binding site [chemical binding]; other site 990317005664 hypothetical protein; Provisional; Region: PRK02302 990317005665 Protein of unknown function (DUF964); Region: DUF964; pfam06133 990317005666 Protease subunit of ATP-dependent Clp proteases [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: ClpP; COG0740 990317005667 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 990317005668 oligomer interface [polypeptide binding]; other site 990317005669 active site residues [active] 990317005670 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 990317005671 EamA-like transporter family; Region: EamA; pfam00892 990317005672 Transcriptional regulator [Transcription]; Region: LysR; COG0583 990317005673 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 990317005674 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 990317005675 dimerization interface [polypeptide binding]; other site 990317005676 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 990317005677 active site 990317005678 Bifunctional PLP-dependent enzyme with beta-cystathionase and maltose regulon repressor activities [Amino acid transport and metabolism]; Region: MalY; COG1168 990317005679 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 990317005680 pyridoxal 5'-phosphate binding site [chemical binding]; other site 990317005681 homodimer interface [polypeptide binding]; other site 990317005682 catalytic residue [active] 990317005683 cystathionine gamma-synthase; Reviewed; Region: PRK07269 990317005684 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 990317005685 homodimer interface [polypeptide binding]; other site 990317005686 substrate-cofactor binding pocket; other site 990317005687 pyridoxal 5'-phosphate binding site [chemical binding]; other site 990317005688 catalytic residue [active] 990317005689 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 990317005690 Stage V sporulation protein B, also known as Stage III sporulation protein F, and related proteins; Region: MATE_SpoVB_like; cd13124 990317005691 UDP-N-acetylmuramoylalanyl-D-glutamate--L-lysine ligase; Provisional; Region: PRK14022 990317005692 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 990317005693 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 990317005694 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 990317005695 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 990317005696 Walker A/P-loop; other site 990317005697 ATP binding site [chemical binding]; other site 990317005698 Q-loop/lid; other site 990317005699 ABC transporter signature motif; other site 990317005700 Walker B; other site 990317005701 D-loop; other site 990317005702 H-loop/switch region; other site 990317005703 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 990317005704 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 990317005705 intersubunit interface [polypeptide binding]; other site 990317005706 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 990317005707 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 990317005708 ABC-ATPase subunit interface; other site 990317005709 dimer interface [polypeptide binding]; other site 990317005710 putative PBP binding regions; other site 990317005711 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 990317005712 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 990317005713 ABC-ATPase subunit interface; other site 990317005714 dimer interface [polypeptide binding]; other site 990317005715 putative PBP binding regions; other site 990317005716 Domain of unknown function (DUF1803); Region: DUF1803; pfam08820 990317005717 Domain of unknown function (DUF1803); Region: DUF1803; pfam08820 990317005718 Orthopoxvirus protein of unknown function (DUF830); Region: DUF830; pfam05708 990317005719 hypothetical protein; Validated; Region: PRK02101 990317005720 putative manganese-dependent inorganic pyrophosphatase; Provisional; Region: PRK05427 990317005721 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 990317005722 DHHA2 domain; Region: DHHA2; pfam02833 990317005723 pyruvate formate-lyase 1-activating enzyme; Region: PFLA; TIGR02493 990317005724 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 990317005725 FeS/SAM binding site; other site 990317005726 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 990317005727 Domain of unknown function DUF21; Region: DUF21; pfam01595 990317005728 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 990317005729 Transporter associated domain; Region: CorC_HlyC; smart01091 990317005730 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 990317005731 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 990317005732 Walker A/P-loop; other site 990317005733 ATP binding site [chemical binding]; other site 990317005734 Q-loop/lid; other site 990317005735 ABC transporter signature motif; other site 990317005736 Walker B; other site 990317005737 D-loop; other site 990317005738 H-loop/switch region; other site 990317005739 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 990317005740 Putative rRNA methylase; Region: rRNA_methylase; pfam06962 990317005741 Predicted Fe-S oxidoreductase [General function prediction only]; Region: COG1242 990317005742 PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392 990317005743 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 990317005744 active site 990317005745 Predicted membrane protein [Function unknown]; Region: COG2510 990317005746 Predicted membrane protein [Function unknown]; Region: COG3601 990317005747 Protein of unknown function (DUF3816); Region: DUF3816; pfam12822 990317005748 Predicted rRNA methylase (SpoU class) [Translation, ribosomal structure and biogenesis]; Region: CspR; COG0219 990317005749 short chain dehydrogenase; Provisional; Region: PRK07454 990317005750 classical (c) SDRs; Region: SDR_c; cd05233 990317005751 NAD(P) binding site [chemical binding]; other site 990317005752 active site 990317005753 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 990317005754 Helix-Turn-Helix DNA binding domain of the MerR-like transcription regulators YyaN and YraB; Region: HTH_YyaN; cd01109 990317005755 DNA binding residues [nucleotide binding] 990317005756 putative dimer interface [polypeptide binding]; other site 990317005757 Amino acid permease; Region: AA_permease_2; pfam13520 990317005758 K+ potassium transporter; Region: K_trans; cl15781 990317005759 potassium transporter peripheral membrane component; Reviewed; Region: trkA; PRK09496 990317005760 TrkA-N domain; Region: TrkA_N; pfam02254 990317005761 TrkA-C domain; Region: TrkA_C; pfam02080 990317005762 TrkA-N domain; Region: TrkA_N; pfam02254 990317005763 TrkA-C domain; Region: TrkA_C; pfam02080 990317005764 Trk-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: TrkG; COG0168 990317005765 potassium uptake protein, TrkH family; Region: 2a38; TIGR00933 990317005766 hypothetical protein; Validated; Region: PRK00041 990317005767 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 990317005768 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 990317005769 RNA binding surface [nucleotide binding]; other site 990317005770 Pseudouridine synthases, RsuA subfamily; Region: PseudoU_synth_RsuA_like; cd02870 990317005771 active site 990317005772 segregation and condensation protein B; Reviewed; Region: scpB; PRK00135 990317005773 segregation and condensation protein A; Reviewed; Region: scpA; PRK00104 990317005774 site-specific tyrosine recombinase XerD-like protein; Reviewed; Region: xerD; PRK02436 990317005775 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 990317005776 active site 990317005777 Int/Topo IB signature motif; other site 990317005778 catalytic residues [active] 990317005779 DNA binding site [nucleotide binding] 990317005780 FOG: CBS domain [General function prediction only]; Region: COG0517 990317005781 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_30; cd04643 990317005782 Escherichia coli YfcE and related proteins, metallophosphatase domain; Region: MPP_YfcE; cd00841 990317005783 active site 990317005784 metal binding site [ion binding]; metal-binding site 990317005785 homotetramer interface [polypeptide binding]; other site 990317005786 putative deoxyribonucleotide triphosphate pyrophosphatase/unknown domain fusion protein; Reviewed; Region: PRK02491 990317005787 NTPase/HAM1. This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515 990317005788 active site 990317005789 dimerization interface [polypeptide binding]; other site 990317005790 glutamate racemase; Provisional; Region: PRK00865 990317005791 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3763 990317005792 Diaminopimelate decarboxylase [Amino acid transport and metabolism]; Region: LysA; COG0019 990317005793 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828 990317005794 active site 990317005795 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 990317005796 substrate binding site [chemical binding]; other site 990317005797 catalytic residues [active] 990317005798 dimer interface [polypeptide binding]; other site 990317005799 Integral membrane protein, interacts with FtsH [General function prediction only]; Region: COG0670 990317005800 Bacterial BAX inhibitor (BI)-1/YccA-like proteins; Region: BI-1-like_bacterial; cd10432 990317005801 Predicted HD superfamily hydrolase [General function prediction only]; Region: COG1418 990317005802 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 990317005803 Zn2+ binding site [ion binding]; other site 990317005804 Mg2+ binding site [ion binding]; other site 990317005805 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 990317005806 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; smart00967 990317005807 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 990317005808 acylphosphatase; Provisional; Region: PRK14434 990317005809 OxaA-like protein precursor; Provisional; Region: PRK02463 990317005810 membrane protein insertase, YidC/Oxa1 family, C-terminal domain; Region: yidC_oxa1_cterm; TIGR03592 990317005811 transcription elongation factor GreA; Reviewed; Region: greA; PRK00226 990317005812 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 990317005813 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 990317005814 YceG-like family; Region: YceG; pfam02618 990317005815 proteins similar to Escherichia coli yceG; Region: yceG_like; cd08010 990317005816 dimerization interface [polypeptide binding]; other site 990317005817 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 990317005818 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 990317005819 Coenzyme A binding pocket [chemical binding]; other site 990317005820 UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421 990317005821 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 990317005822 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 990317005823 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 990317005824 Bacterial SNF2 helicase associated; Region: SNF2_assoc; pfam08455 990317005825 SNF2 family N-terminal domain; Region: SNF2_N; pfam00176 990317005826 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 990317005827 ATP binding site [chemical binding]; other site 990317005828 putative Mg++ binding site [ion binding]; other site 990317005829 Superfamily II DNA and RNA helicases [DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis]; Region: SrmB; COG0513 990317005830 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 990317005831 nucleotide binding region [chemical binding]; other site 990317005832 ATP-binding site [chemical binding]; other site 990317005833 GTP-binding protein Der; Reviewed; Region: PRK00093 990317005834 EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894 990317005835 G1 box; other site 990317005836 GTP/Mg2+ binding site [chemical binding]; other site 990317005837 Switch I region; other site 990317005838 G2 box; other site 990317005839 Switch II region; other site 990317005840 G3 box; other site 990317005841 G4 box; other site 990317005842 G5 box; other site 990317005843 EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895 990317005844 G1 box; other site 990317005845 GTP/Mg2+ binding site [chemical binding]; other site 990317005846 Switch I region; other site 990317005847 G2 box; other site 990317005848 G3 box; other site 990317005849 Switch II region; other site 990317005850 G4 box; other site 990317005851 G5 box; other site 990317005852 primosomal protein DnaI; Reviewed; Region: PRK08939 990317005853 Primosomal protein DnaI N-terminus; Region: DnaI_N; pfam07319 990317005854 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 990317005855 Walker A motif; other site 990317005856 ATP binding site [chemical binding]; other site 990317005857 Walker B motif; other site 990317005858 Replication initiation/membrane attachment protein [DNA replication, recombination, and repair]; Region: DnaB; COG3611 990317005859 transcriptional regulator NrdR; Validated; Region: nrdR; PRK00464 990317005860 ATP cone domain; Region: ATP-cone; pfam03477 990317005861 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 990317005862 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 990317005863 dimerization interface [polypeptide binding]; other site 990317005864 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 990317005865 dimer interface [polypeptide binding]; other site 990317005866 phosphorylation site [posttranslational modification] 990317005867 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 990317005868 ATP binding site [chemical binding]; other site 990317005869 Mg2+ binding site [ion binding]; other site 990317005870 G-X-G motif; other site 990317005871 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 990317005872 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 990317005873 active site 990317005874 phosphorylation site [posttranslational modification] 990317005875 intermolecular recognition site; other site 990317005876 dimerization interface [polypeptide binding]; other site 990317005877 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 990317005878 DNA binding site [nucleotide binding] 990317005879 Predicted metal-binding, possibly nucleic acid-binding protein [General function prediction only]; Region: COG1399 990317005880 heat shock protein HtpX; Provisional; Region: PRK04897 990317005881 Uncharacterized conserved protein [Function unknown]; Region: LemA; COG1704 990317005882 Predicted S-adenosylmethionine-dependent methyltransferase involved in bacterial cell division [Cell envelope biogenesis, outer membrane]; Region: GidB; COG0357 990317005883 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 990317005884 S-adenosylmethionine binding site [chemical binding]; other site 990317005885 Trk-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: TrkG; COG0168 990317005886 potassium uptake protein, TrkH family; Region: 2a38; TIGR00933 990317005887 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 990317005888 TrkA-N domain; Region: TrkA_N; pfam02254 990317005889 TrkA-C domain; Region: TrkA_C; pfam02080 990317005890 ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619 990317005891 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 990317005892 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 990317005893 Walker A/P-loop; other site 990317005894 ATP binding site [chemical binding]; other site 990317005895 Q-loop/lid; other site 990317005896 ABC transporter signature motif; other site 990317005897 Walker B; other site 990317005898 D-loop; other site 990317005899 H-loop/switch region; other site 990317005900 ATP-binding cassette cobalt transporter; Region: DUF3744; pfam12558 990317005901 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 990317005902 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 990317005903 Walker A/P-loop; other site 990317005904 ATP binding site [chemical binding]; other site 990317005905 Q-loop/lid; other site 990317005906 ABC transporter signature motif; other site 990317005907 Walker B; other site 990317005908 D-loop; other site 990317005909 H-loop/switch region; other site 990317005910 hypothetical protein; Provisional; Region: PRK13661 990317005911 Uncharacterized conserved protein [Function unknown]; Region: COG1912 990317005912 serine/threonine transporter SstT; Provisional; Region: PRK13628 990317005913 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 990317005914 Branched-chain amino acid transport protein; Region: Branch_AA_trans; cl00547 990317005915 biliverdin IX beta reductase (BVR-B, aka flavin reductase)-like proteins; atypical (a) SDRs; Region: BVR-B_like_SDR_a; cd05244 990317005916 NADH(P)-binding; Region: NAD_binding_10; pfam13460 990317005917 NAD binding site [chemical binding]; other site 990317005918 substrate binding site [chemical binding]; other site 990317005919 putative active site [active] 990317005920 Predicted transcriptional regulator [Transcription]; Region: COG1959 990317005921 Transcriptional regulator; Region: Rrf2; pfam02082 990317005922 Transcriptional regulator; Region: Rrf2; cl17282 990317005923 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 990317005924 dimer interface [polypeptide binding]; other site 990317005925 conserved gate region; other site 990317005926 ABC-ATPase subunit interface; other site 990317005927 ABC-type metal ion transport system, ATPase component [Inorganic ion transport and metabolism]; Region: AbcC; COG1135 990317005928 ATP-binding cassette domain of methionine transporter; Region: ABC_MetN_methionine_transporter; cd03258 990317005929 Walker A/P-loop; other site 990317005930 ATP binding site [chemical binding]; other site 990317005931 Q-loop/lid; other site 990317005932 ABC transporter signature motif; other site 990317005933 Walker B; other site 990317005934 D-loop; other site 990317005935 H-loop/switch region; other site 990317005936 NIL domain; Region: NIL; pfam09383 990317005937 hypothetical protein; Provisional; Region: PRK06446 990317005938 Uncharacterized M20 Dipeptidases; Region: M20_dipept_like_4; cd05681 990317005939 metal binding site [ion binding]; metal-binding site 990317005940 dimer interface [polypeptide binding]; other site 990317005941 ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464 990317005942 NLPA lipoprotein; Region: Lipoprotein_9; pfam03180 990317005943 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 990317005944 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 990317005945 substrate binding pocket [chemical binding]; other site 990317005946 membrane-bound complex binding site; other site 990317005947 hinge residues; other site 990317005948 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 990317005949 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 990317005950 metal binding site [ion binding]; metal-binding site 990317005951 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 990317005952 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 990317005953 substrate binding pocket [chemical binding]; other site 990317005954 membrane-bound complex binding site; other site 990317005955 hinge residues; other site 990317005956 Peptidase C26; Region: Peptidase_C26; pfam07722 990317005957 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_2; cd01745 990317005958 catalytic triad [active] 990317005959 hypothetical protein; Provisional; Region: PRK12378 990317005960 hypothetical protein; Provisional; Region: PRK13670 990317005961 HIGH Nucleotidyl Transferase; Region: HIGH_NTase1; pfam05636 990317005962 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 990317005963 S-adenosylmethionine binding site [chemical binding]; other site 990317005964 Uncharacterized homolog of plant Iojap protein [Function unknown]; Region: COG0799 990317005965 Isochorismatase family; Region: Isochorismatase; pfam00857 990317005966 Nicotinamidase_ related amidohydrolases. Cysteine hydrolases of unknown function that share the catalytic triad with other amidohydrolases, like nicotinamidase, which converts nicotinamide to nicotinic acid and ammonia; Region: nicotinamidase_related; cd01014 990317005967 catalytic triad [active] 990317005968 conserved cis-peptide bond; other site 990317005969 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 990317005970 Zn2+ binding site [ion binding]; other site 990317005971 Mg2+ binding site [ion binding]; other site 990317005972 nicotinic acid mononucleotide adenylyltransferase; Provisional; Region: nadD; PRK00071 990317005973 Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165 990317005974 active site 990317005975 (T/H)XGH motif; other site 990317005976 Predicted RNA-binding protein containing KH domain, possibly ribosomal protein [Translation, ribosomal structure and biogenesis]; Region: COG1534 990317005977 GTPase YqeH; Provisional; Region: PRK13796 990317005978 Circularly permuted YqeH GTPase; Region: YqeH; cd01855 990317005979 GTP/Mg2+ binding site [chemical binding]; other site 990317005980 G4 box; other site 990317005981 G5 box; other site 990317005982 G1 box; other site 990317005983 Switch I region; other site 990317005984 G2 box; other site 990317005985 G3 box; other site 990317005986 Switch II region; other site 990317005987 Predicted hydrolase of the HAD superfamily [General function prediction only]; Region: COG2179 990317005988 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 990317005989 active site 990317005990 motif I; other site 990317005991 motif II; other site 990317005992 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 990317005993 Major Facilitator Superfamily; Region: MFS_1; pfam07690 990317005994 putative substrate translocation pore; other site 990317005995 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 990317005996 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 990317005997 MarR family; Region: MarR_2; pfam12802 990317005998 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 990317005999 EamA-like transporter family; Region: EamA; pfam00892 990317006000 aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477 990317006001 GatB/GatE catalytic domain; Region: GatB_N; pfam02934 990317006002 GatB domain; Region: GatB_Yqey; pfam02637 990317006003 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 990317006004 aspartyl/glutamyl-tRNA amidotransferase subunit A; Reviewed; Region: gatA; PRK00012 990317006005 aspartyl/glutamyl-tRNA amidotransferase subunit C; Reviewed; Region: gatC; PRK00034 990317006006 Isochorismatase family; Region: Isochorismatase; pfam00857 990317006007 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 990317006008 catalytic triad [active] 990317006009 conserved cis-peptide bond; other site 990317006010 transcriptional repressor CodY; Validated; Region: PRK04158 990317006011 CodY GAF-like domain; Region: CodY; pfam06018 990317006012 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 990317006013 dimerization interface [polypeptide binding]; other site 990317006014 putative Zn2+ binding site [ion binding]; other site 990317006015 putative DNA binding site [nucleotide binding]; other site 990317006016 aminotransferase AlaT; Validated; Region: PRK09265 990317006017 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 990317006018 pyridoxal 5'-phosphate binding site [chemical binding]; other site 990317006019 homodimer interface [polypeptide binding]; other site 990317006020 catalytic residue [active] 990317006021 Membrane domain of glycerophosphoryl diester phosphodiesterase; Region: GPDPase_memb; cl01974 990317006022 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 990317006023 Glycerophosphodiester phosphodiesterase domain of uncharacterized bacterial glycerophosphodiester phosphodiesterases; Region: GDPD_memb_like; cd08579 990317006024 putative active site [active] 990317006025 catalytic site [active] 990317006026 putative metal binding site [ion binding]; other site 990317006027 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 990317006028 Ligand Binding Site [chemical binding]; other site 990317006029 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 990317006030 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 990317006031 active site 990317006032 motif I; other site 990317006033 motif II; other site 990317006034 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 990317006035 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 990317006036 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4696 990317006037 metal binding site [ion binding]; metal-binding site 990317006038 Type II (periplasmic) bacterial L-asparaginase; Region: L-asparaginase_II; cd08964 990317006039 active site 990317006040 homotetramer interface [polypeptide binding]; other site 990317006041 homodimer interface [polypeptide binding]; other site 990317006042 Predicted transcriptional regulator [Transcription]; Region: COG3655 990317006043 sequence-specific DNA binding site [nucleotide binding]; other site 990317006044 salt bridge; other site 990317006045 ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917 990317006046 RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488 990317006047 generic binding surface II; other site 990317006048 ssDNA binding site; other site 990317006049 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 990317006050 ATP binding site [chemical binding]; other site 990317006051 putative Mg++ binding site [ion binding]; other site 990317006052 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 990317006053 nucleotide binding region [chemical binding]; other site 990317006054 ATP-binding site [chemical binding]; other site 990317006055 alanine racemase; Reviewed; Region: alr; PRK00053 990317006056 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430 990317006057 active site 990317006058 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 990317006059 dimer interface [polypeptide binding]; other site 990317006060 substrate binding site [chemical binding]; other site 990317006061 catalytic residues [active] 990317006062 4'-phosphopantetheinyl transferase; Provisional; Region: acpS; PRK00070 990317006063 3-deoxy-D-arabino-heptulosonate 7-phosphate (DAHP) synthase [Amino acid transport and metabolism]; Region: AroG; cl17260 990317006064 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 990317006065 3-deoxy-D-arabino-heptulosonate 7-phosphate (DAHP) synthase [Amino acid transport and metabolism]; Region: AroG; COG0722 990317006066 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 990317006067 preprotein translocase subunit SecA; Reviewed; Region: PRK12904 990317006068 SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958 990317006069 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 990317006070 nucleotide binding region [chemical binding]; other site 990317006071 ATP-binding site [chemical binding]; other site 990317006072 SEC-C motif; Region: SEC-C; pfam02810 990317006073 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 990317006074 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 990317006075 nucleotide binding site [chemical binding]; other site 990317006076 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 990317006077 PTS system, sucrose-specific IIBC component; Region: PTS-II-BC-sucr; TIGR01996 990317006078 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 990317006079 active site turn [active] 990317006080 phosphorylation site [posttranslational modification] 990317006081 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 990317006082 PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_glc; cd00210 990317006083 HPr interaction site; other site 990317006084 glycerol kinase (GK) interaction site [polypeptide binding]; other site 990317006085 active site 990317006086 phosphorylation site [posttranslational modification] 990317006087 sucrose-6-phosphate hydrolase; Region: scrB_fam; TIGR01322 990317006088 Glycosyl hydrolase family 32, beta-fructosidases; Region: GH32_B_Fructosidase; cd08996 990317006089 substrate binding [chemical binding]; other site 990317006090 active site 990317006091 Glycosyl hydrolases family 32 C terminal; Region: Glyco_hydro_32C; pfam08244 990317006092 Transcriptional regulators [Transcription]; Region: PurR; COG1609 990317006093 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 990317006094 DNA binding site [nucleotide binding] 990317006095 domain linker motif; other site 990317006096 Ligand binding domain of the lacI-like transcription regulator from a novel metal-reducing bacterium Alkaliphilus Metalliredigens (strain Qymf) and its close homologs; Region: PBP1_Qymf_like; cd06291 990317006097 dimerization interface [polypeptide binding]; other site 990317006098 ligand binding site [chemical binding]; other site 990317006099 sodium binding site [ion binding]; other site 990317006100 transcription antitermination protein NusB; Reviewed; Region: nusB; PRK00202 990317006101 putative RNA binding site [nucleotide binding]; other site 990317006102 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1302 990317006103 elongation factor P; Validated; Region: PRK00529 990317006104 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 990317006105 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 990317006106 RNA binding site [nucleotide binding]; other site 990317006107 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 990317006108 RNA binding site [nucleotide binding]; other site 990317006109 Protein of unknown function (DUF2628); Region: DUF2628; pfam10947 990317006110 Tim44-like domain; Region: Tim44; cl09208 990317006111 Deoxycytidylate deaminase domain. Deoxycytidylate deaminase catalyzes the deamination of dCMP to dUMP, providing the nucleotide substrate for thymidylate synthase. The enzyme binds Zn++, which is required for catalytic activity. The activity of the...; Region: deoxycytidylate_deaminase; cd01286 990317006112 catalytic motif [active] 990317006113 Zn binding site [ion binding]; other site 990317006114 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 990317006115 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 990317006116 Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092 990317006117 active site 990317006118 excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349 990317006119 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 990317006120 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 990317006121 ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271 990317006122 Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598 990317006123 uncharacterized bacterial subfamily of the Escherichia coli CorA-Salmonella typhimurium ZntB family; Region: EcCorA_ZntB-like_u2; cd12827 990317006124 Cl binding site [ion binding]; other site 990317006125 oligomer interface [polypeptide binding]; other site 990317006126 Protein of unknown function (DUF1129); Region: DUF1129; cl11555 990317006127 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 990317006128 non-specific DNA binding site [nucleotide binding]; other site 990317006129 salt bridge; other site 990317006130 sequence-specific DNA binding site [nucleotide binding]; other site 990317006131 30S ribosomal protein S18; Reviewed; Region: rpsR; PRK00391 990317006132 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 990317006133 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 990317006134 dimer interface [polypeptide binding]; other site 990317006135 ssDNA binding site [nucleotide binding]; other site 990317006136 tetramer (dimer of dimers) interface [polypeptide binding]; other site 990317006137 30S ribosomal protein S6; Reviewed; Region: rpsF; PRK00453 990317006138 BioY family; Region: BioY; pfam02632 990317006139 AAA domain; Region: AAA_26; pfam13500 990317006140 dithiobiotin synthetase; Reviewed; Region: bioD; PRK00090 990317006141 biotin synthase; Region: bioB; TIGR00433 990317006142 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 990317006143 FeS/SAM binding site; other site 990317006144 Biotin and Thiamin Synthesis associated domain; Region: BATS; pfam06968 990317006145 alkyl hydroperoxide reductase subunit F; Provisional; Region: PRK15317 990317006146 Alkyl hydroperoxide reductase F subunit (AhpF) N-terminal domain (NTD) family, N-terminal TRX-fold subdomain; AhpF is a homodimeric flavoenzyme which catalyzes the NADH-dependent reduction of the peroxiredoxin AhpC, which in turn catalyzes the reduction...; Region: AhpF_NTD_N; cd02974 990317006147 catalytic residue [active] 990317006148 TRX-GRX-like family, Alkyl hydroperoxide reductase F subunit (AhpF) N-terminal domain (NTD) subfamily, C-terminal TRX-fold subdomain; AhpF is a homodimeric flavoenzyme which catalyzes the NADH-dependent reduction of the peroxiredoxin AhpC, which then...; Region: AhpF_NTD_C; cd03026 990317006149 catalytic residues [active] 990317006150 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 990317006151 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 990317006152 peroxiredoxin; Region: AhpC; TIGR03137 990317006153 Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015 990317006154 dimer interface [polypeptide binding]; other site 990317006155 decamer (pentamer of dimers) interface [polypeptide binding]; other site 990317006156 catalytic triad [active] 990317006157 peroxidatic and resolving cysteines [active] 990317006158 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 990317006159 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 990317006160 Walker A/P-loop; other site 990317006161 ATP binding site [chemical binding]; other site 990317006162 Q-loop/lid; other site 990317006163 ABC transporter signature motif; other site 990317006164 Walker B; other site 990317006165 D-loop; other site 990317006166 H-loop/switch region; other site 990317006167 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 990317006168 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 990317006169 dimer interface [polypeptide binding]; other site 990317006170 conserved gate region; other site 990317006171 putative PBP binding loops; other site 990317006172 ABC-ATPase subunit interface; other site 990317006173 ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728 990317006174 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 990317006175 substrate binding pocket [chemical binding]; other site 990317006176 membrane-bound complex binding site; other site 990317006177 hinge residues; other site 990317006178 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 990317006179 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 990317006180 Subfamily of fatty acid CoA ligase (FACL) similar to Fum10p of Gibberella moniliformis; Region: FACL_fum10p_like; cd05926 990317006181 acyl-activating enzyme (AAE) consensus motif; other site 990317006182 acyl-activating enzyme (AAE) consensus motif; other site 990317006183 putative AMP binding site [chemical binding]; other site 990317006184 putative active site [active] 990317006185 putative CoA binding site [chemical binding]; other site 990317006186 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 990317006187 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 990317006188 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 990317006189 acyl-activating enzyme (AAE) consensus motif; other site 990317006190 acyl-activating enzyme (AAE) consensus motif; other site 990317006191 AMP binding site [chemical binding]; other site 990317006192 active site 990317006193 CoA binding site [chemical binding]; other site 990317006194 Acyltransferase family; Region: Acyl_transf_3; pfam01757 990317006195 A/G-specific DNA glycosylase [DNA replication, recombination, and repair]; Region: MutY; COG1194 990317006196 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 990317006197 minor groove reading motif; other site 990317006198 helix-hairpin-helix signature motif; other site 990317006199 substrate binding pocket [chemical binding]; other site 990317006200 active site 990317006201 DNA glycosylase (MutY in bacteria and hMYH in humans) is responsible for repairing misread A*oxoG residues to C*G by removing the inappropriately paired adenine base from the DNA backbone. It belongs to the Nudix hydrolase superfamily and is important...; Region: DNA_Glycosylase_C; cd03431 990317006202 DNA binding and oxoG recognition site [nucleotide binding] 990317006203 Glutathione-dependent formaldehyde-activating enzyme; Region: GFA; pfam04828 990317006204 oxalate/formate antiporter family transporter; Region: 2A0111; TIGR00890 990317006205 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 990317006206 putative substrate translocation pore; other site 990317006207 Predicted flavoprotein [General function prediction only]; Region: COG0431 990317006208 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 990317006209 Predicted flavoprotein [General function prediction only]; Region: COG0431 990317006210 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 990317006211 FMN-binding domain; Region: FMN_bind; pfam04205 990317006212 flavocytochrome c; Region: flavo_cyto_c; TIGR01813 990317006213 L-aspartate oxidase; Provisional; Region: PRK06175 990317006214 Protein of unknown function (DUF2992); Region: DUF2992; pfam11208 990317006215 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 990317006216 formaldehyde dehydrogenase (FDH)-like; Region: FDH_like_ADH3; cd08287 990317006217 catalytic Zn binding site [ion binding]; other site 990317006218 NAD(P) binding site [chemical binding]; other site 990317006219 structural Zn binding site [ion binding]; other site 990317006220 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 990317006221 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 990317006222 catalytic residues [active] 990317006223 PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cd01610 990317006224 active site 990317006225 Nicotinate-nucleotide pyrophosphorylase [Coenzyme metabolism]; Region: NadC; COG0157 990317006226 Quinolinate phosphoribosyl transferase (QAPRTase or QPRTase), also called nicotinate-nucleotide pyrophosphorylase, is involved in the de novo synthesis of NAD in both prokaryotes and eukaryotes. It catalyses the reaction of quinolinic acid (QA) with...; Region: QPRTase; cd01572 990317006227 dimerization interface [polypeptide binding]; other site 990317006228 active site 990317006229 L-aspartate oxidase; Provisional; Region: PRK06175 990317006230 FAD binding domain; Region: FAD_binding_2; pfam00890 990317006231 Quinolinate synthetase A protein; Region: NadA; pfam02445 990317006232 Mismatch repair ATPase (MutS family) [DNA replication, recombination, and repair]; Region: COG1193 990317006233 MutS domain III; Region: MutS_III; pfam05192 990317006234 ATP-binding cassette domain of MutS2; Region: ABC_MutS2; cd03280 990317006235 Walker A/P-loop; other site 990317006236 ATP binding site [chemical binding]; other site 990317006237 Q-loop/lid; other site 990317006238 ABC transporter signature motif; other site 990317006239 Walker B; other site 990317006240 D-loop; other site 990317006241 H-loop/switch region; other site 990317006242 Smr domain; Region: Smr; pfam01713 990317006243 Uncharacterized membrane protein, required for colicin V production [General function prediction only]; Region: CvpA; COG1286 990317006244 Colicin V production protein; Region: Colicin_V; pfam02674 990317006245 Protein of unknown function (DUF1211); Region: DUF1211; pfam06736 990317006246 potential frameshift: common BLAST hit: gi|288906131|ref|YP_003431353.1| nitroreductase 990317006247 Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer, utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cl00514 990317006248 Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer, utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cl00514 990317006249 FMN binding site [chemical binding]; other site 990317006250 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 990317006251 Old yellow enzyme (OYE)-related FMN binding domain, group 4. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a reducing agent with oxygens, quinones, and alpha,beta-unsaturated aldehydes and ketones, and can act as...; Region: OYE_like_4_FMN; cd04735 990317006252 putative active site [active] 990317006253 putative FMN binding site [chemical binding]; other site 990317006254 putative substrate binding site [chemical binding]; other site 990317006255 putative catalytic residue [active] 990317006256 Predicted transcriptional regulators [Transcription]; Region: COG1733 990317006257 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 990317006258 ribonuclease HIII; Provisional; Region: PRK00996 990317006259 Domain of unknown function (DUF3378); Region: DUF3378; pfam11858 990317006260 bacterial Ribonuclease HIII-like; Region: RNase_HII_bacteria_HIII_like; cd06590 990317006261 RNA/DNA hybrid binding site [nucleotide binding]; other site 990317006262 active site 990317006263 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 990317006264 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 990317006265 Catalytic site [active] 990317006266 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 990317006267 helicase, putative, RecD/TraA family; Region: recD_rel; TIGR01448 990317006268 H3TH domains of structure-specific 5' nucleases (or flap endonuclease-1-like) involved in DNA replication, repair, and recombination; Region: H3TH_StructSpec-5'-nucleases; cl14815 990317006269 AAA domain; Region: AAA_30; pfam13604 990317006270 Family description; Region: UvrD_C_2; pfam13538 990317006271 DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586 990317006272 active site 990317006273 DNA polymerase IV; Validated; Region: PRK02406 990317006274 DNA binding site [nucleotide binding] 990317006275 formate acetyltransferase 1; Region: pyr_form_ly_1; TIGR01255 990317006276 Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939 990317006277 Acetyltransferase (GNAT) domain; Region: Acetyltransf_5; cl17496 990317006278 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 990317006279 Coenzyme A binding pocket [chemical binding]; other site 990317006280 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 990317006281 Beta-lactamase; Region: Beta-lactamase; pfam00144 990317006282 Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cd00333 990317006283 amphipathic channel; other site 990317006284 Asn-Pro-Ala signature motifs; other site 990317006285 x-prolyl-dipeptidyl aminopeptidase; Provisional; Region: PRK05371 990317006286 X-Prolyl dipeptidyl aminopeptidase PepX, N-terminal; Region: PepX_N; pfam09168 990317006287 X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain; Region: PepX_C; pfam08530 990317006288 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 990317006289 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 990317006290 dimer interface [polypeptide binding]; other site 990317006291 phosphorylation site [posttranslational modification] 990317006292 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 990317006293 ATP binding site [chemical binding]; other site 990317006294 Mg2+ binding site [ion binding]; other site 990317006295 G-X-G motif; other site 990317006296 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 990317006297 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 990317006298 active site 990317006299 phosphorylation site [posttranslational modification] 990317006300 intermolecular recognition site; other site 990317006301 dimerization interface [polypeptide binding]; other site 990317006302 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 990317006303 DNA binding site [nucleotide binding] 990317006304 phosphate transport system regulatory protein PhoU; Region: phoU_full; TIGR02135 990317006305 PhoU domain; Region: PhoU; pfam01895 990317006306 PhoU domain; Region: PhoU; pfam01895 990317006307 phosphate transporter ATP-binding protein; Provisional; Region: PRK14240 990317006308 ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260 990317006309 Walker A/P-loop; other site 990317006310 ATP binding site [chemical binding]; other site 990317006311 Q-loop/lid; other site 990317006312 ABC transporter signature motif; other site 990317006313 Walker B; other site 990317006314 D-loop; other site 990317006315 H-loop/switch region; other site 990317006316 phosphate ABC transporter, permease protein PstA; Region: 3a0107s02c; TIGR00974 990317006317 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 990317006318 dimer interface [polypeptide binding]; other site 990317006319 conserved gate region; other site 990317006320 putative PBP binding loops; other site 990317006321 ABC-ATPase subunit interface; other site 990317006322 phosphate ABC transporter, permease protein PstC; Region: phosphate_pstC; TIGR02138 990317006323 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 990317006324 dimer interface [polypeptide binding]; other site 990317006325 conserved gate region; other site 990317006326 putative PBP binding loops; other site 990317006327 ABC-ATPase subunit interface; other site 990317006328 PBP superfamily domain; Region: PBP_like_2; cl17296 990317006329 PBP superfamily domain; Region: PBP_like_2; cl17296 990317006330 hypothetical protein; Validated; Region: PRK00153 990317006331 Protease prsW family; Region: PrsW-protease; pfam13367 990317006332 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 990317006333 Helix-Turn-Helix DNA binding domain of the transcription regulators TipAL, Mta, and SkgA; Region: HTH_TipAL-Mta; cd01106 990317006334 DNA binding residues [nucleotide binding] 990317006335 dimer interface [polypeptide binding]; other site 990317006336 DNA polymerase III, epsilon subunit and related 3'-5' exonucleases [DNA replication, recombination, and repair]; Region: DnaQ; COG0847 990317006337 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 990317006338 active site 990317006339 catalytic site [active] 990317006340 substrate binding site [chemical binding]; other site 990317006341 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cl17220 990317006342 HI0933-like protein; Region: HI0933_like; pfam03486 990317006343 hydroxyglutarate oxidase; Provisional; Region: PRK11728 990317006344 Chromate resistance exported protein; Region: Chrome_Resist; cl01744 990317006345 30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08881 990317006346 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 990317006347 Threonine aldolase [Amino acid transport and metabolism]; Region: GLY1; COG2008 990317006348 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 990317006349 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 990317006350 catalytic residue [active] 990317006351 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 990317006352 Winged helix DNA-binding domain; Region: HTH_27; pfam13463 990317006353 Predicted membrane protein [Function unknown]; Region: COG4392 990317006354 Predicted branched-chain amino acid permease (azaleucine resistance) [Amino acid transport and metabolism]; Region: AzlC; COG1296 990317006355 Hexulose-6-phosphate isomerase (PHI). PHI is a member of the SIS (Sugar ISomerase domain) superfamily. In the ribulose monophosphate pathway of formaldehyde fixation, hexulose-6-phosphate synthase catalyzes the condensation of ribulose-5-phosphate with...; Region: SIS_PHI; cd05005 990317006356 tetramer interface [polypeptide binding]; other site 990317006357 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 990317006358 active site 990317006359 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 990317006360 active site 990317006361 phosphorylation site [posttranslational modification] 990317006362 PTS_IIB_galactitol: subunit IIB of enzyme II (EII) of the galactitol-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is a galactitol-specific permease with two cytoplasmic domains (IIA and IIB) and a...; Region: PTS_IIB_galactitol; cd05566 990317006363 active site 990317006364 P-loop; other site 990317006365 phosphorylation site [posttranslational modification] 990317006366 Phosphotransferase system, galactitol-specific IIC component [Carbohydrate transport and metabolism]; Region: GatC; COG3775 990317006367 PTS system sugar-specific permease component; Region: EIIC-GAT; cl04451 990317006368 Ribose/Galactose Isomerase; Region: LacAB_rpiB; cl00485 990317006369 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 990317006370 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 990317006371 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 990317006372 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cl00220 990317006373 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cl00220 990317006374 UGMP family protein; Validated; Region: PRK09604 990317006375 tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725 990317006376 Carbamoyltransferase; Region: CmcH_NodU; pfam02543 990317006377 ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575 990317006378 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 990317006379 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 990317006380 Coenzyme A binding pocket [chemical binding]; other site 990317006381 tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725 990317006382 Glycoprotease family; Region: Peptidase_M22; pfam00814 990317006383 hypothetical protein; Provisional; Region: PRK13667 990317006384 mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595 990317006385 Metallo-beta-lactamase superfamily; Region: Lactamase_B; pfam00753 990317006386 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 990317006387 FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388 990317006388 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 990317006389 Surface antigen [General function prediction only]; Region: COG3942 990317006390 CHAP domain; Region: CHAP; pfam05257 990317006391 glutamate synthase subunit beta; Reviewed; Region: gltD; PRK12810 990317006392 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 990317006393 Formate/glycerate dehydrogenases, D-specific 2-hydroxy acid dehydrogenases and related dehydrogenases; Region: FDH_GDH_like; cl17240 990317006394 NAD binding site [chemical binding]; other site 990317006395 glutamate synthase subunit alpha; Provisional; Region: gltB; PRK11750 990317006396 Glutamine amidotransferases class-II (Gn-AT), glutamate synthase (GltS)-type. GltS is a homodimer that synthesizes L-glutamate from 2-oxoglutarate and L-glutamine, an important step in ammonia assimilation in bacteria, cyanobacteria and plants. The...; Region: GltS; cd00713 990317006397 active site 990317006398 dimer interface [polypeptide binding]; other site 990317006399 Glutamate synthase central domain; Region: Glu_syn_central; pfam04898 990317006400 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808 990317006401 active site 990317006402 FMN binding site [chemical binding]; other site 990317006403 substrate binding site [chemical binding]; other site 990317006404 3Fe-4S cluster binding site [ion binding]; other site 990317006405 gltb_C. This domain is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS). GltS encodes a complex iron-sulfur flavoprotein that catalyzes the synthesis of L-glutamate from L-glutamine and 2-oxoglutarate. It requires the...; Region: gltB_C; cd00982 990317006406 domain interface; other site 990317006407 Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174 990317006408 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 990317006409 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 990317006410 Helix-Turn-Helix DNA binding domain of GlnR-like transcription regulators; Region: HTH_GlnR-like; cd01105 990317006411 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 990317006412 DNA binding residues [nucleotide binding] 990317006413 putative dimer interface [polypeptide binding]; other site 990317006414 Predicted membrane protein [Function unknown]; Region: COG4129 990317006415 phosphoglycerate kinase; Provisional; Region: pgk; PRK00073 990317006416 Phosphoglycerate kinase; Region: PGK; pfam00162 990317006417 substrate binding site [chemical binding]; other site 990317006418 hinge regions; other site 990317006419 ADP binding site [chemical binding]; other site 990317006420 catalytic site [active] 990317006421 Glyceraldehyde-3-phosphate dehydrogenase/erythrose-4-phosphate dehydrogenase [Carbohydrate transport and metabolism]; Region: GapA; COG0057 990317006422 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846 990317006423 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 990317006424 elongation factor G; Reviewed; Region: PRK00007 990317006425 Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886 990317006426 G1 box; other site 990317006427 putative GEF interaction site [polypeptide binding]; other site 990317006428 GTP/Mg2+ binding site [chemical binding]; other site 990317006429 Switch I region; other site 990317006430 G2 box; other site 990317006431 G3 box; other site 990317006432 Switch II region; other site 990317006433 G4 box; other site 990317006434 G5 box; other site 990317006435 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 990317006436 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 990317006437 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 990317006438 30S ribosomal protein S7; Validated; Region: PRK05302 990317006439 S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368 990317006440 S17 interaction site [polypeptide binding]; other site 990317006441 S8 interaction site; other site 990317006442 16S rRNA interaction site [nucleotide binding]; other site 990317006443 streptomycin interaction site [chemical binding]; other site 990317006444 23S rRNA interaction site [nucleotide binding]; other site 990317006445 aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site 990317006446 pur operon repressor; Provisional; Region: PRK09213 990317006447 Bacterial purine repressor, N-terminal; Region: PuR_N; pfam09182 990317006448 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 990317006449 active site 990317006450 Predicted HD-superfamily hydrolase [General function prediction only]; Region: COG3481 990317006451 YhaM_OBF_like: A subfamily of OB folds similar to that found in Bacillus subtilis YhaM and Staphylococcus aureus cmp-binding factor-1 (SaCBF1). Both these proteins are 3'-to-5'exoribonucleases. YhaM requires Mn2+ or Co2+ for activity and is...; Region: YhaM_OBF_like; cd04492 990317006452 generic binding surface II; other site 990317006453 generic binding surface I; other site 990317006454 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 990317006455 Zn2+ binding site [ion binding]; other site 990317006456 Mg2+ binding site [ion binding]; other site 990317006457 Predicted nuclease of restriction endonuclease-like fold, RmuC family [General function prediction only]; Region: COG1322 990317006458 RmuC family; Region: RmuC; pfam02646 990317006459 Thiamine pyrophosphokinase [Coenzyme metabolism]; Region: THI80; COG1564 990317006460 Thiamine pyrophosphokinase; Region: TPK; cd07995 990317006461 active site 990317006462 dimerization interface [polypeptide binding]; other site 990317006463 thiamine binding site [chemical binding]; other site 990317006464 Pentose-5-phosphate-3-epimerase [Carbohydrate transport and metabolism]; Region: Rpe; COG0036 990317006465 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 990317006466 substrate binding site [chemical binding]; other site 990317006467 hexamer interface [polypeptide binding]; other site 990317006468 metal binding site [ion binding]; metal-binding site 990317006469 GTPase RsgA; Reviewed; Region: PRK00098 990317006470 S1_YloQ_GTPase: YloQ GTase family (also known as YjeQ and CpgA), S1-like RNA-binding domain. Proteins in the YloQ GTase family bind the ribosome and have GTPase activity. The precise role of this family is unknown. The protein structure is composed of...; Region: S1_YloQ_GTPase; cd04466 990317006471 RNA binding site [nucleotide binding]; other site 990317006472 homodimer interface [polypeptide binding]; other site 990317006473 Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854 990317006474 GTPase/Zn-binding domain interface [polypeptide binding]; other site 990317006475 GTP/Mg2+ binding site [chemical binding]; other site 990317006476 G4 box; other site 990317006477 G1 box; other site 990317006478 Switch I region; other site 990317006479 G2 box; other site 990317006480 G3 box; other site 990317006481 Switch II region; other site 990317006482 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 990317006483 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 990317006484 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 990317006485 active site 990317006486 phosphorylation site [posttranslational modification] 990317006487 intermolecular recognition site; other site 990317006488 dimerization interface [polypeptide binding]; other site 990317006489 LytTr DNA-binding domain; Region: LytTR; pfam04397 990317006490 Enterocin A Immunity; Region: EntA_Immun; pfam08951 990317006491 Enterocin A Immunity; Region: EntA_Immun; pfam08951 990317006492 Protein of unknown function (DUF3884); Region: DUF3884; pfam13024 990317006493 Predicted signal transduction protein with a C-terminal ATPase domain [Signal transduction mechanisms]; Region: COG2972 990317006494 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 990317006495 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 990317006496 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 990317006497 active site 990317006498 phosphorylation site [posttranslational modification] 990317006499 intermolecular recognition site; other site 990317006500 dimerization interface [polypeptide binding]; other site 990317006501 LytTr DNA-binding domain; Region: LytTR; pfam04397 990317006502 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 990317006503 UDP-glucose LOS-beta-1,4 glucosyltransferase is required for biosynthesis of lipooligosaccharide; Region: Beta4Glucosyltransferase; cd02511 990317006504 putative metal binding site; other site 990317006505 Protein of unknown function (DUF3884); Region: DUF3884; pfam13024 990317006506 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 990317006507 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 990317006508 non-specific DNA binding site [nucleotide binding]; other site 990317006509 salt bridge; other site 990317006510 sequence-specific DNA binding site [nucleotide binding]; other site 990317006511 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 990317006512 Bacteriocin class II with double-glycine leader peptide; Region: Bacteriocin_IIc; pfam10439 990317006513 A sub-family of peptidase family C39. Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various...; Region: Peptidase_C39B; cd02418 990317006514 ABC-type bacteriocin transporter; Region: bacteriocin_ABC; TIGR01193 990317006515 putative active site [active] 990317006516 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 990317006517 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 990317006518 Walker A/P-loop; other site 990317006519 ATP binding site [chemical binding]; other site 990317006520 Q-loop/lid; other site 990317006521 ABC transporter signature motif; other site 990317006522 Walker B; other site 990317006523 D-loop; other site 990317006524 H-loop/switch region; other site 990317006525 bacteriocin secretion accessory protein; Region: bacteriocin_acc; TIGR01000 990317006526 HlyD family secretion protein; Region: HlyD_3; pfam13437 990317006527 CAAX protease self-immunity; Region: Abi; pfam02517 990317006528 CAAX protease self-immunity; Region: Abi; pfam02517 990317006529 16S ribosomal RNA methyltransferase KsgA/Dim1 family protein; Reviewed; Region: ksgA; PRK00274 990317006530 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 990317006531 S-adenosylmethionine binding site [chemical binding]; other site 990317006532 Protein of unknown function (DUF1697); Region: DUF1697; pfam08002 990317006533 ribonuclease M5; Region: 5S_RNA_mat_M5; TIGR00334 990317006534 TOPRIM_ RNase M5_like: The topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain found in Ribonuclease M5: (RNase M5) and other small primase-like proteins from bacteria and archaea. RNase M5 catalyzes the maturation of 5S rRNA in low...; Region: TOPRIM_RNase_M5_like; cd01027 990317006535 putative active site [active] 990317006536 putative metal binding site [ion binding]; other site 990317006537 Domain of unknown function (DUF4093); Region: DUF4093; pfam13331 990317006538 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 990317006539 Predicted metal-dependent hydrolases with the TIM-barrel fold [General function prediction only]; Region: COG1099 990317006540 active site 990317006541 TQXA domain; Region: TQXA_dom; TIGR03934 990317006542 Repeat unit of collagen-binding protein domain B; Region: CollagenBindB; cd00222 990317006543 domain interaction interfaces [polypeptide binding]; other site 990317006544 Repeat unit of collagen-binding protein domain B; Region: CollagenBindB; cd00222 990317006545 domain interaction interfaces [polypeptide binding]; other site 990317006546 Repeat unit of collagen-binding protein domain B; Region: CollagenBindB; cd00222 990317006547 domain interaction interfaces [polypeptide binding]; other site 990317006548 Repeat unit of collagen-binding protein domain B; Region: CollagenBindB; cd00222 990317006549 domain interaction interfaces [polypeptide binding]; other site 990317006550 L-lactate dehydrogenase; Reviewed; Region: ldh; PRK00066 990317006551 L-2-hydroxyisocapronate dehydrogenases and some bacterial L-lactate dehydrogenases; Region: HicDH_like; cd05291 990317006552 tetramer (dimer of dimers) interface [polypeptide binding]; other site 990317006553 NAD binding site [chemical binding]; other site 990317006554 dimer interface [polypeptide binding]; other site 990317006555 substrate binding site [chemical binding]; other site 990317006556 CAAX protease self-immunity; Region: Abi; pfam02517 990317006557 heavy metal-(Cd/Co/Hg/Pb/Zn)-translocating P-type ATPase; Region: ATPase-IB2_Cd; TIGR01512 990317006558 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 990317006559 Condensing enzymes; Family of enzymes that catalyze a (decarboxylating or non-decarboxylating) Claisen-like condensation reaction. Members are share strong structural similarity, and are involved in the synthesis and degradation of fatty acids, and the...; Region: cond_enzymes; cl09938 990317006560 Soluble P-type ATPase [General function prediction only]; Region: COG4087 990317006561 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 990317006562 Transposase; Region: DDE_Tnp_ISL3; pfam01610 990317006563 Sortase C (SrtC) or subfamily-3 sortases are membrane cysteine transpeptidases found in Gram-positive bacteria that anchor surface proteins to peptidoglycans of the bacterial cell wall envelope. This involves a transpeptidation reaction in which the...; Region: Sortase_C_3; cd05827 990317006564 active site 990317006565 catalytic site [active] 990317006566 LPXTG-motif cell wall anchor domain; Region: LPXTG_anchor; TIGR01167 990317006567 Listeria-Bacteroides repeat domain (List_Bact_rpt); Region: Flg_new; cl09714 990317006568 Listeria-Bacteroides repeat domain (List_Bact_rpt); Region: Flg_new; pfam09479 990317006569 Listeria-Bacteroides repeat domain (List_Bact_rpt); Region: Flg_new; pfam09479 990317006570 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 990317006571 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 990317006572 Catalytic site [active] 990317006573 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 990317006574 S-adenosylmethionine binding site [chemical binding]; other site 990317006575 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 990317006576 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 990317006577 ATP-binding cassette domain of multidrug resistance protein-like transporters; Region: ABCC_MRP_Like; cd03228 990317006578 Walker A/P-loop; other site 990317006579 ATP binding site [chemical binding]; other site 990317006580 Q-loop/lid; other site 990317006581 ABC transporter signature motif; other site 990317006582 Walker B; other site 990317006583 D-loop; other site 990317006584 H-loop/switch region; other site 990317006585 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 990317006586 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 990317006587 ABC-ATPase subunit interface; other site 990317006588 dimer interface [polypeptide binding]; other site 990317006589 putative PBP binding regions; other site 990317006590 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 990317006591 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 990317006592 ABC-type metal ion transport system, periplasmic component/surface adhesin [Inorganic ion transport and metabolism]; Region: LraI; COG0803 990317006593 Metal binding protein PsaA. These proteins have been shown to function as initial receptors in ABC transport of Mn2+ and as surface adhesins in some eubacterial species. They belong to the TroA superfamily of periplasmic metal binding proteins that...; Region: PsaA; cd01137 990317006594 metal binding site [ion binding]; metal-binding site 990317006595 2-hydroxycarboxylate transporter family; Region: 2HCT; pfam03390 990317006596 malate dehydrogenase; Provisional; Region: PRK13529 990317006597 Malic enzyme, N-terminal domain; Region: malic; pfam00390 990317006598 NAD(P) binding domain of malic enzyme (ME), subgroup 1; Region: NAD_bind_1_malic_enz; cd05312 990317006599 NAD(P) binding site [chemical binding]; other site 990317006600 Transcriptional regulator [Transcription]; Region: LysR; COG0583 990317006601 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 990317006602 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 990317006603 dimerization interface [polypeptide binding]; other site 990317006604 Predicted esterase [General function prediction only]; Region: COG0400 990317006605 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 990317006606 D-alanyl-lipoteichoic acid biosynthesis protein DltD; Region: LTA_DltD; TIGR04092 990317006607 DltD N-terminal region; Region: DltD_N; pfam04915 990317006608 DltD central region; Region: DltD_M; pfam04918 990317006609 DltD C-terminal region; Region: DltD_C; pfam04914 990317006610 D-alanine--poly(phosphoribitol) ligase subunit 2; Validated; Region: PRK05087 990317006611 D-alanyl-lipoteichoic acid biosynthesis protein DltB; Region: LTA_dltB; TIGR04091 990317006612 D-alanine--poly(phosphoribitol) ligase subunit 1; Provisional; Region: PRK04813 990317006613 D-alanine:D-alanyl carrier protein ligase (DltA); Region: DltA; cd05945 990317006614 acyl-activating enzyme (AAE) consensus motif; other site 990317006615 AMP binding site [chemical binding]; other site 990317006616 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3237 990317006617 V-type ATP synthase subunit D; Reviewed; Region: PRK00373 990317006618 V-type ATP synthase subunit B; Provisional; Region: PRK04196 990317006619 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 990317006620 V/A-type ATP synthase (non-catalytic) subunit B. These ATPases couple ATP hydrolysis to the build up of a H+ gradient, but V-type ATPases do not catalyze the reverse reaction. The Vacuolar (V-type) ATPase is found in the membranes of vacuoles, the golgi...; Region: V_A-ATPase_B; cd01135 990317006621 Walker A motif homologous position; other site 990317006622 Walker B motif; other site 990317006623 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 990317006624 V-type ATP synthase subunit A; Provisional; Region: PRK04192 990317006625 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 990317006626 V/A-type ATP synthase catalytic subunit A. These ATPases couple ATP hydrolysis to the build up of a H+ gradient, but V-type ATPases do not catalyze the reverse reaction. The Vacuolar (V-type) ATPase is found in the membranes of vacuoles, the golgi...; Region: V_A-ATPase_A; cd01134 990317006627 Walker A motif/ATP binding site; other site 990317006628 Walker B motif; other site 990317006629 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 990317006630 V-type ATP synthase subunit F; Provisional; Region: PRK01395 990317006631 Archaeal/vacuolar-type H+-ATPase subunit C [Energy production and conversion]; Region: NtpC; COG1527 990317006632 V-type ATP synthase subunit C; Provisional; Region: PRK01198; cl00660 990317006633 V-type ATP synthase subunit K; Validated; Region: PRK06558 990317006634 ATP synthase subunit C; Region: ATP-synt_C; pfam00137 990317006635 V-type ATP synthase subunit I; Validated; Region: PRK05771 990317006636 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 990317006637 Major Facilitator Superfamily; Region: MFS_1; pfam07690 990317006638 putative substrate translocation pore; other site 990317006639 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 990317006640 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 990317006641 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 990317006642 Ribosomal protein L34; Region: Ribosomal_L34; cl00370 990317006643 Uncharacterized protein family (UPF0236); Region: UPF0236; pfam06782 990317006644 Glucan-binding protein C; Region: GbpC; pfam08363 990317006645 Sortases are cysteine transpeptidases, found in gram-positive bacteria, that anchor surface proteins to peptidoglycans of the bacterial cell wall envelope. They do so by catalyzing a transpeptidation reaction in which the surface protein substrate is...; Region: Sortase; cl09098 990317006646 active site 990317006647 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 990317006648 putative phosphoesterase; Region: acc_ester; TIGR03729 990317006649 Stage 0 sporulation protein J (antagonist of Soj) containing ParB-like nuclease domain [Transcription]; Region: Spo0J; COG1475 990317006650 ParB-like nuclease domain; Region: ParBc; pfam02195 990317006651 DNA modification methylase [DNA replication, recombination, and repair]; Region: COG0863 990317006652 DNA methylase; Region: N6_N4_Mtase; pfam01555 990317006653 Relaxase/Mobilisation nuclease domain; Region: Relaxase; pfam03432 990317006654 Bacterial mobilisation protein (MobC); Region: MobC; pfam05713 990317006655 Protein of unknown function (DUF3991); Region: DUF3991; pfam13154 990317006656 Toprim-like; Region: Toprim_2; pfam13155 990317006657 Domain of unknown function (DUF955); Region: DUF955; cl01076 990317006658 AAA-like domain; Region: AAA_10; pfam12846 990317006659 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 990317006660 Walker A motif; other site 990317006661 ATP binding site [chemical binding]; other site 990317006662 Walker B motif; other site 990317006663 CHAP domain; Region: CHAP; pfam05257 990317006664 Surface antigen [General function prediction only]; Region: COG3942 990317006665 AAA-like domain; Region: AAA_10; pfam12846 990317006666 PrgI family protein; Region: PrgI; pfam12666 990317006667 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 990317006668 potential frameshift: common BLAST hit: gi|288905868|ref|YP_003431090.1| peptidoglycan linked protein (LPXTG motif) 990317006669 LPXTG-motif cell wall anchor domain; Region: LPXTG_anchor; TIGR01167 990317006670 putative cross-wall-targeting lipoprotein signal; Region: strep_RK_lipo; TIGR03726 990317006671 LPXTG-motif cell wall anchor domain; Region: LPXTG_anchor; TIGR01167 990317006672 Replication initiator protein A (RepA) N-terminus; Region: RepA_N; pfam06970 990317006673 Protein of unknown function (DUF3021); Region: DUF3021; pfam11457 990317006674 LytTr DNA-binding domain; Region: LytTR; smart00850 990317006675 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 990317006676 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 990317006677 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 990317006678 Walker A/P-loop; other site 990317006679 ATP binding site [chemical binding]; other site 990317006680 Q-loop/lid; other site 990317006681 ABC transporter signature motif; other site 990317006682 Walker B; other site 990317006683 D-loop; other site 990317006684 H-loop/switch region; other site 990317006685 Predicted RNA-binding protein [General function prediction only]; Region: Jag; COG1847 990317006686 jag_K homology RNA-binding domain. The KH domain is found in proteins homologous to the Bacillus subtilis protein Jag, which is associated with SpoIIIJ and is necessary for the third stage of sporulation. The KH motif is a beta-alpha-alpha-beta-beta...; Region: jag_KH; cd02414 990317006687 G-X-X-G motif; other site 990317006688 R3H domain found in proteins homologous to Bacillus subtilus Jag, which is associated with SpoIIIJ. SpoIIIJ is necessary for the third stage of sporulation. The name of the R3H domain comes from the characteristic spacing of the most conserved arginine...; Region: R3H_jag; cd02644 990317006689 RxxxH motif; other site 990317006690 Preprotein translocase subunit YidC [Intracellular trafficking and secretion]; Region: YidC; COG0706 990317006691 membrane protein insertase, YidC/Oxa1 family, C-terminal domain; Region: yidC_oxa1_cterm; TIGR03592 990317006692 ribonuclease P; Reviewed; Region: rnpA; PRK00499 990317006693 argininosuccinate lyase; Provisional; Region: PRK00855 990317006694 Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359 990317006695 active sites [active] 990317006696 tetramer interface [polypeptide binding]; other site 990317006697 argininosuccinate synthase; Provisional; Region: PRK13820 990317006698 Argininosuccinate synthase. The Argininosuccinate synthase is a urea cycle enzyme that catalyzes the penultimate step in arginine biosynthesis: the ATP-dependent ligation of citrulline to aspartate to form argininosuccinate, AMP and pyrophosphate . In...; Region: Argininosuccinate_Synthase; cd01999 990317006699 ANP binding site [chemical binding]; other site 990317006700 Substrate Binding Site II [chemical binding]; other site 990317006701 Substrate Binding Site I [chemical binding]; other site 990317006702 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 990317006703 H+ Antiporter protein; Region: 2A0121; TIGR00900 990317006704 putative substrate translocation pore; other site 990317006705 Cyanate permease [Inorganic ion transport and metabolism]; Region: CynX; COG2807 990317006706 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 990317006707 putative substrate translocation pore; other site 990317006708 glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406 990317006709 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 990317006710 active site 990317006711 HIGH motif; other site 990317006712 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 990317006713 active site 990317006714 KMSKS motif; other site 990317006715 Tubby C 2; Region: Tub_2; cl02043 990317006716 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeD; cd03379 990317006717 active site clefts [active] 990317006718 zinc binding site [ion binding]; other site 990317006719 dimer interface [polypeptide binding]; other site 990317006720 DNA repair protein RadA; Provisional; Region: PRK11823 990317006721 Sms (bacterial radA) DNA repair protein. This protein is not related to archael radA any more than is to other RecA-like NTPases. Sms has a role in recombination and recombinational repair and is responsible for the stabilization or processing of...; Region: Sms; cd01121 990317006722 Walker A motif/ATP binding site; other site 990317006723 ATP binding site [chemical binding]; other site 990317006724 Walker B motif; other site 990317006725 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 990317006726 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 990317006727 trimer interface [polypeptide binding]; other site 990317006728 active site 990317006729 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1636 990317006730 NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094 990317006731 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 990317006732 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479 990317006733 Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541 990317006734 dTDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: RfbA; COG1209 990317006735 active site 990317006736 tetramer interface; other site 990317006737 Rhomboid family; Region: Rhomboid; pfam01694 990317006738 5,10-methenyltetrahydrofolate synthetase; Region: MTHFS_bact; TIGR02727 990317006739 5-formyltetrahydrofolate cyclo-ligase family; Region: 5-FTHF_cyc-lig; pfam01812 990317006740 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 990317006741 M20 Peptidase Aminoacyclase-1 YkuR-like proteins, including YkuR and Ama/HipO/HyuC proteins; Region: M20_Acy1_YkuR_like; cd05670 990317006742 metal binding site [ion binding]; metal-binding site 990317006743 putative dimer interface [polypeptide binding]; other site 990317006744 Tetrahydrodipicolinate succinyltransferase N-terminal; Region: DapH_N; pfam08503 990317006745 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-acetyltransferase; Region: DapD_Ac; TIGR03532 990317006746 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate (THDP) N-succinyltransferase (also called THP succinyltransferase): THDP N-succinyltransferase catalyzes the conversion of tetrahydrodipicolinate and succinyl-CoA to N-succinyltetrahydrodipicolinate and CoA; Region: LbH_THP_succinylT; cd03350 990317006747 trimer interface [polypeptide binding]; other site 990317006748 active site 990317006749 substrate binding site [chemical binding]; other site 990317006750 CoA binding site [chemical binding]; other site 990317006751 glucose-6-phosphate isomerase; Provisional; Region: pgi; PRK14097 990317006752 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015 990317006753 active site 990317006754 dimer interface [polypeptide binding]; other site 990317006755 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016 990317006756 dimer interface [polypeptide binding]; other site 990317006757 active site 990317006758 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 990317006759 nucleoside/Zn binding site; other site 990317006760 dimer interface [polypeptide binding]; other site 990317006761 catalytic motif [active] 990317006762 Metal-dependent hydrolases of the beta-lactamase superfamily III [General function prediction only]; Region: ElaC; COG1234 990317006763 Uncharacterized conserved protein [General function prediction only]; Region: BioY; COG1268 990317006764 queuine tRNA-ribosyltransferase; Provisional; Region: tgt; PRK00112 990317006765 Queuine/archaeosine tRNA-ribosyltransferase [Translation, ribosomal structure and biogenesis]; Region: Tgt; COG0343 990317006766 Protein of unknown function (DUF975); Region: DUF975; cl10504 990317006767 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 990317006768 metal binding site 2 [ion binding]; metal-binding site 990317006769 putative DNA binding helix; other site 990317006770 metal binding site 1 [ion binding]; metal-binding site 990317006771 dimer interface [polypeptide binding]; other site 990317006772 structural Zn2+ binding site [ion binding]; other site 990317006773 Phenolic acid decarboxylase (PAD); Region: PA_decarbox; pfam05870 990317006774 Predicted transcriptional regulators [Transcription]; Region: COG1695 990317006775 Transcriptional regulator PadR-like family; Region: PadR; cl17335 990317006776 Virulence activator alpha C-term; Region: Vir_act_alpha_C; pfam10400 990317006777 Predicted CoA-binding protein [General function prediction only]; Region: COG1832 990317006778 DNA polymerase I; Provisional; Region: PRK05755 990317006779 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 990317006780 active site 990317006781 metal binding site 1 [ion binding]; metal-binding site 990317006782 putative 5' ssDNA interaction site; other site 990317006783 metal binding site 3; metal-binding site 990317006784 metal binding site 2 [ion binding]; metal-binding site 990317006785 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 990317006786 putative DNA binding site [nucleotide binding]; other site 990317006787 putative metal binding site [ion binding]; other site 990317006788 inactive DEDDy 3'-5' exonuclease domain of Bacillus stearothermophilus DNA polymerase I and similar family-A DNA polymerases; Region: DNA_polA_I_Bacillus_like_exo; cd06140 990317006789 Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637 990317006790 active site 990317006791 DNA binding site [nucleotide binding] 990317006792 catalytic site [active] 990317006793 Membrane transport protein; Region: Mem_trans; pfam03547 990317006794 Transketolase [Carbohydrate transport and metabolism]; Region: TktA; COG0021 990317006795 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 990317006796 TPP-binding site [chemical binding]; other site 990317006797 dimer interface [polypeptide binding]; other site 990317006798 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 990317006799 PYR/PP interface [polypeptide binding]; other site 990317006800 dimer interface [polypeptide binding]; other site 990317006801 TPP binding site [chemical binding]; other site 990317006802 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 990317006803 Transaldolase-like fructose-6-phosphate aldolases (FSA) found in bacteria and archaea; Region: Transaldolase_FSA; cd00956 990317006804 active site 990317006805 intersubunit interactions; other site 990317006806 catalytic residue [active] 990317006807 putative L-ascorbate 6-phosphate lactonase; Provisional; Region: PRK11709 990317006808 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 990317006809 Transcriptional antiterminator [Transcription]; Region: BglG; COG3711 990317006810 Mga helix-turn-helix domain; Region: Mga; pfam05043 990317006811 PRD domain; Region: PRD; pfam00874 990317006812 PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568 990317006813 active site 990317006814 P-loop; other site 990317006815 phosphorylation site [posttranslational modification] 990317006816 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 990317006817 active site 990317006818 phosphorylation site [posttranslational modification] 990317006819 2-keto-3-deoxy-6-phosphogluconate aldolase [Carbohydrate transport and metabolism]; Region: Eda; COG0800 990317006820 KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452 990317006821 active site 990317006822 intersubunit interface [polypeptide binding]; other site 990317006823 catalytic residue [active] 990317006824 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 990317006825 Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408 990317006826 inhibitor site; inhibition site 990317006827 active site 990317006828 dimer interface [polypeptide binding]; other site 990317006829 catalytic residue [active] 990317006830 KpsF-like protein. KpsF is an arabinose-5-phosphate isomerase which contains SIS (Sugar ISomerase) domains. SIS domains are found in many phosphosugar isomerases and phosphosugar binding proteins. KpsF catalyzes the reversible reaction of ribulose...; Region: SIS_Kpsf; cd05014 990317006831 putative active site [active] 990317006832 PTS system ascorbate-specific transporter subunit IIC; Reviewed; Region: PRK12997 990317006833 PTS_IIB_ascorbate: subunit IIB of enzyme II (EII) of the L-ascorbate-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is an L-ascorbate-specific permease with two cytoplasmic subunits (IIA and IIB) and a...; Region: PTS_IIB_ascorbate; cd05563 990317006834 active site 990317006835 P-loop; other site 990317006836 phosphorylation site [posttranslational modification] 990317006837 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 990317006838 active site 990317006839 phosphorylation site [posttranslational modification] 990317006840 Transcriptional antiterminator [Transcription]; Region: BglG; COG3711 990317006841 PRD domain; Region: PRD; pfam00874 990317006842 PRD domain; Region: PRD; pfam00874 990317006843 PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568 990317006844 active site 990317006845 P-loop; other site 990317006846 phosphorylation site [posttranslational modification] 990317006847 L-ribulose-5-phosphate 4-epimerase; Provisional; Region: araD; PRK13145 990317006848 L-ribulose-5-phosphate 4-epimerase; Reviewed; Region: araD; PRK08193 990317006849 intersubunit interface [polypeptide binding]; other site 990317006850 active site 990317006851 Zn2+ binding site [ion binding]; other site 990317006852 putative L-xylulose 5-phosphate 3-epimerase; Reviewed; Region: PRK13210 990317006853 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cd00019 990317006854 AP (apurinic/apyrimidinic) site pocket; other site 990317006855 DNA interaction; other site 990317006856 Metal-binding active site; metal-binding site 990317006857 3-Keto-L-gulonate 6-phosphate decarboxylase (KGPDC) and D-arabino-3-hexulose-6-phosphate synthase (HPS). KGPDC catalyzes the formation of L-xylulose 5-phosphate and carbon dioxide from 3-keto-L-gulonate 6-phosphate as part of the anaerobic pathway for...; Region: KGPDC_HPS; cd04726 990317006858 active site 990317006859 dimer interface [polypeptide binding]; other site 990317006860 magnesium binding site [ion binding]; other site 990317006861 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 990317006862 active site 990317006863 phosphorylation site [posttranslational modification] 990317006864 PTS_IIB_ascorbate: subunit IIB of enzyme II (EII) of the L-ascorbate-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is an L-ascorbate-specific permease with two cytoplasmic subunits (IIA and IIB) and a...; Region: PTS_IIB_ascorbate; cd05563 990317006865 active site 990317006866 P-loop; other site 990317006867 phosphorylation site [posttranslational modification] 990317006868 PTS system ascorbate-specific transporter subunit IIC; Reviewed; Region: PRK12997 990317006869 Uncharacterized conserved protein [Function unknown]; Region: COG2128 990317006870 Uncharacterized oxidoreductases, Fe-dependent alcohol dehydrogenase family [Energy production and conversion]; Region: COG1979 990317006871 Dehydroquinate synthase-like (DHQ-like) and iron-containing alcohol dehydrogenases (Fe-ADH); Region: DHQ_Fe-ADH; cl02872 990317006872 active site 990317006873 NAD binding site [chemical binding]; other site 990317006874 metal binding site [ion binding]; metal-binding site 990317006875 ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464 990317006876 NLPA lipoprotein; Region: Lipoprotein_9; pfam03180 990317006877 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 990317006878 ABC-ATPase subunit interface; other site 990317006879 DL-methionine transporter ATP-binding subunit; Provisional; Region: metN; PRK11153 990317006880 ATP-binding cassette domain of methionine transporter; Region: ABC_MetN_methionine_transporter; cd03258 990317006881 Walker A/P-loop; other site 990317006882 ATP binding site [chemical binding]; other site 990317006883 Q-loop/lid; other site 990317006884 ABC transporter signature motif; other site 990317006885 Walker B; other site 990317006886 D-loop; other site 990317006887 H-loop/switch region; other site 990317006888 NIL domain; Region: NIL; pfam09383 990317006889 Transcriptional regulator; Region: Rrf2; cl17282 990317006890 Rrf2 family protein; Region: rrf2_super; TIGR00738 990317006891 Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788 990317006892 Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108 990317006893 GDP-binding site [chemical binding]; other site 990317006894 ACT binding site; other site 990317006895 IMP binding site; other site 990317006896 bifunctional glutamate--cysteine ligase/glutathione synthetase; Provisional; Region: PRK02471 990317006897 Glutamate-cysteine ligase; Region: Glu_cys_ligase; cl17352 990317006898 ATP-grasp domain; Region: ATP-grasp_4; cl17255 990317006899 phage transcriptional regulator, ArpU family; Region: phage_arpU; TIGR01637 990317006900 D5 N terminal like; Region: D5_N; smart00885 990317006901 phage/plasmid primase, P4 family, C-terminal domain; Region: primase_Cterm; TIGR01613 990317006902 Poxvirus D5 protein-like; Region: Pox_D5; pfam03288 990317006903 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 990317006904 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 990317006905 non-specific DNA binding site [nucleotide binding]; other site 990317006906 salt bridge; other site 990317006907 sequence-specific DNA binding site [nucleotide binding]; other site 990317006908 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 990317006909 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 990317006910 non-specific DNA binding site [nucleotide binding]; other site 990317006911 salt bridge; other site 990317006912 sequence-specific DNA binding site [nucleotide binding]; other site 990317006913 Domain of unknown function (DUF955); Region: DUF955; pfam06114 990317006914 Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582 990317006915 phiLC3 phage and phage-related integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes various bacterial (mainly gram positive) and phage integrases, including those similar to Lactococcus...; Region: INT_phiLC3_C; cd01189 990317006916 Int/Topo IB signature motif; other site 990317006917 Uncharacterized protein involved in tellurite resistance [Inorganic ion transport and metabolism]; Region: TelA; COG3853 990317006918 LytTr DNA-binding domain; Region: LytTR; smart00850 990317006919 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 990317006920 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 990317006921 Walker A/P-loop; other site 990317006922 ATP binding site [chemical binding]; other site 990317006923 Q-loop/lid; other site 990317006924 ABC transporter signature motif; other site 990317006925 Walker B; other site 990317006926 D-loop; other site 990317006927 H-loop/switch region; other site 990317006928 This family is the oxydase domain of NRPS (non-ribosomal peptide synthetase) and other proteins that modify polypeptides by cyclizing a thioester to form a ring. These include epoB, part of the epothilone biosynthesis pathway; tubD, part of the tubulysin...; Region: mcbC-like_oxidoreductase; cd02142 990317006929 NADPH bind site [chemical binding]; other site 990317006930 YcaO-like family; Region: YcaO; pfam02624 990317006931 thiazole/oxazole-forming peptide maturase, SagD family component; Region: TOMM_cyclo_SagD; TIGR03604 990317006932 Hsp33-like chaperonin; Reviewed; Region: hslO; PRK00114 990317006933 Heat shock protein 33 (Hsp33): Cytosolic protein that acts as a molecular chaperone under oxidative conditions. In normal (reducing) cytosolic conditions, four conserved Cys residues are coordinated by a Zn ion. Under oxidative stress (such as heat...; Region: Hsp33; cd00498 990317006934 dimerization interface [polypeptide binding]; other site 990317006935 domain crossover interface; other site 990317006936 redox-dependent activation switch; other site 990317006937 putative TIM-barrel protein, nifR3 family; Region: nifR3_yhdG; TIGR00737 990317006938 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 990317006939 FMN binding site [chemical binding]; other site 990317006940 active site 990317006941 catalytic residues [active] 990317006942 substrate binding site [chemical binding]; other site 990317006943 ATP-binding subunits of Clp protease and DnaK/DnaJ chaperones [Posttranslational modification, protein turnover, chaperones]; Region: clpA; COG0542 990317006944 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 990317006945 Walker A motif; other site 990317006946 ATP binding site [chemical binding]; other site 990317006947 Walker B motif; other site 990317006948 arginine finger; other site 990317006949 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 990317006950 Walker A motif; other site 990317006951 ATP binding site [chemical binding]; other site 990317006952 Walker B motif; other site 990317006953 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 990317006954 Firmicute transcriptional repressor of class III stress genes (CtsR); Region: CtsR; pfam05848 990317006955 Putative small multi-drug export protein; Region: Sm_multidrug_ex; pfam06695 990317006956 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 990317006957 non-specific DNA binding site [nucleotide binding]; other site 990317006958 salt bridge; other site 990317006959 sequence-specific DNA binding site [nucleotide binding]; other site 990317006960 H+ Antiporter protein; Region: 2A0121; TIGR00900 990317006961 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 990317006962 putative substrate translocation pore; other site 990317006963 elongation factor Ts; Provisional; Region: tsf; PRK09377 990317006964 UBA/TS-N domain; Region: UBA; pfam00627 990317006965 Elongation factor TS; Region: EF_TS; pfam00889 990317006966 Elongation factor TS; Region: EF_TS; pfam00889 990317006967 Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425 990317006968 rRNA interaction site [nucleotide binding]; other site 990317006969 S8 interaction site; other site 990317006970 putative laminin-1 binding site; other site 990317006971 Microcin C7 self-immunity protein determines resistance to exogenous microcin C7; Region: Peptidase_S66_mccF_like; cd07062 990317006972 putative dimer interface [polypeptide binding]; other site 990317006973 catalytic triad [active] 990317006974 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 990317006975 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 990317006976 non-specific DNA binding site [nucleotide binding]; other site 990317006977 salt bridge; other site 990317006978 sequence-specific DNA binding site [nucleotide binding]; other site 990317006979 transcriptional activator, Rgg/GadR/MutR family, C-terminal domain; Region: RGG_Cterm; TIGR01716 990317006980 Predicted metalloendopeptidase [Posttranslational modification, protein turnover, chaperones]; Region: PepO; COG3590 990317006981 Peptidase family M13 includes neprilysin, endothelin-converting enzyme I; Region: M13; cd08662 990317006982 active site 990317006983 Zn binding site [ion binding]; other site 990317006984 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 990317006985 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 990317006986 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 990317006987 alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403 990317006988 Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333 990317006989 Ca binding site [ion binding]; other site 990317006990 active site 990317006991 catalytic site [active] 990317006992 PTS system, trehalose-specific IIBC component; Region: PTS-IIBC-Tre; TIGR01992 990317006993 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 990317006994 active site turn [active] 990317006995 phosphorylation site [posttranslational modification] 990317006996 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 990317006997 Phosphotransferase system IIA components [Carbohydrate transport and metabolism]; Region: NagE; COG2190 990317006998 HPr interaction site; other site 990317006999 glycerol kinase (GK) interaction site [polypeptide binding]; other site 990317007000 active site 990317007001 phosphorylation site [posttranslational modification] 990317007002 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 990317007003 DNA-binding site [nucleotide binding]; DNA binding site 990317007004 trehalose operon repressor, B. subtilis-type; Region: trehalos_R_Bsub; TIGR02404 990317007005 UTRA domain; Region: UTRA; pfam07702 990317007006 Sortase C (SrtC) or subfamily-3 sortases are membrane cysteine transpeptidases found in Gram-positive bacteria that anchor surface proteins to peptidoglycans of the bacterial cell wall envelope. This involves a transpeptidation reaction in which the...; Region: Sortase_C_3; cd05827 990317007007 active site 990317007008 catalytic site [active] 990317007009 fimbrial isopeptide formation D2 domain; Region: RrgB_K2N_iso_D2; TIGR04226 990317007010 Cna protein B-type domain; Region: Cna_B; pfam05738 990317007011 LPXTG-motif cell wall anchor domain; Region: LPXTG_anchor; TIGR01167 990317007012 Collagen binding domain; Region: Collagen_bind; pfam05737 990317007013 Repeat unit of collagen-binding protein domain B; Region: CollagenBindB; cd00222 990317007014 domain interaction interfaces [polypeptide binding]; other site 990317007015 Repeat unit of collagen-binding protein domain B; Region: CollagenBindB; cd00222 990317007016 domain interaction interfaces [polypeptide binding]; other site 990317007017 Repeat unit of collagen-binding protein domain B; Region: CollagenBindB; cd00222 990317007018 domain interaction interfaces [polypeptide binding]; other site 990317007019 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 990317007020 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 990317007021 Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080 990317007022 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 990317007023 Walker A motif; other site 990317007024 ATP binding site [chemical binding]; other site 990317007025 Walker B motif; other site 990317007026 arginine finger; other site 990317007027 Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491 990317007028 4Fe-4S single cluster domain; Region: Fer4_12; pfam13353 990317007029 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 990317007030 FeS/SAM binding site; other site 990317007031 Predicted acetyltransferase [General function prediction only]; Region: COG3981 990317007032 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 990317007033 anaerobic ribonucleoside triphosphate reductase; Provisional; Region: PRK09263 990317007034 ATP cone domain; Region: ATP-cone; pfam03477 990317007035 Class III ribonucleotide reductase; Region: RNR_III; cd01675 990317007036 effector binding site; other site 990317007037 active site 990317007038 Zn binding site [ion binding]; other site 990317007039 glycine loop; other site 990317007040 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 990317007041 hypothetical protein; Provisional; Region: PRK13678 990317007042 Holliday junction resolvase-like protein; Reviewed; Region: PRK00109 990317007043 hypothetical protein; Provisional; Region: PRK05473 990317007044 Arsenate Reductase (ArsC) family, Spx subfamily; Spx is a unique RNA polymerase (RNAP)-binding protein present in bacilli and some mollicutes. It inhibits transcription by binding to the C-terminal domain of the alpha subunit of RNAP, disrupting complex...; Region: ArsC_Spx; cd03032 990317007045 ArsC family; Region: ArsC; pfam03960 990317007046 putative catalytic residues [active] 990317007047 thiol/disulfide switch; other site 990317007048 recombinase A; Provisional; Region: recA; PRK09354 990317007049 RecA is a bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response. RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983 990317007050 hexamer interface [polypeptide binding]; other site 990317007051 Walker A motif; other site 990317007052 ATP binding site [chemical binding]; other site 990317007053 Walker B motif; other site 990317007054 competence damage-inducible protein A; Provisional; Region: PRK00549 990317007055 Competence-damaged protein. CinA is the first gene in the competence- inducible (cin) operon and is thought to be specifically required at some stage in the process of transformation. This domain is closely related to a domain, found in a variety of...; Region: cinA; cd00885 990317007056 putative MPT binding site; other site 990317007057 Uncharacterized protein (competence- and mitomycin-induced) [General function prediction only]; Region: CinA; COG1546 990317007058 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 990317007059 Major Facilitator Superfamily; Region: MFS_1; pfam07690 990317007060 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 990317007061 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 990317007062 non-specific DNA binding site [nucleotide binding]; other site 990317007063 salt bridge; other site 990317007064 sequence-specific DNA binding site [nucleotide binding]; other site 990317007065 Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116 990317007066 RuvA N terminal domain; Region: RuvA_N; pfam01330 990317007067 DNA mismatch repair protein; Reviewed; Region: mutL; PRK00095 990317007068 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 990317007069 ATP binding site [chemical binding]; other site 990317007070 Mg2+ binding site [ion binding]; other site 990317007071 G-X-G motif; other site 990317007072 MutL_Trans: transducer domain, having a ribosomal S5 domain 2-like fold, conserved in the C-terminal domain of DNA mismatch repair (MutL/MLH1/PMS2) family. This transducer domain is homologous to the second domain of the DNA gyrase B subunit, which is...; Region: MutL_Trans; cd00782 990317007073 ATP binding site [chemical binding]; other site 990317007074 MutL C terminal dimerisation domain; Region: MutL_C; pfam08676 990317007075 DNA mismatch repair protein MutS; Provisional; Region: PRK05399 990317007076 MutS domain I; Region: MutS_I; pfam01624 990317007077 MutS domain II; Region: MutS_II; pfam05188 990317007078 MutS domain III; Region: MutS_III; pfam05192 990317007079 ATP-binding cassette domain of MutS1 homolog; Region: ABC_MutS1; cd03284 990317007080 Walker A/P-loop; other site 990317007081 ATP binding site [chemical binding]; other site 990317007082 Q-loop/lid; other site 990317007083 ABC transporter signature motif; other site 990317007084 Walker B; other site 990317007085 D-loop; other site 990317007086 H-loop/switch region; other site 990317007087 Protein of unknown function (DUF964); Region: DUF964; cl01483 990317007088 Arginine repressor, DNA binding domain; Region: Arg_repressor; pfam01316 990317007089 arginine repressor; Region: argR_whole; TIGR01529 990317007090 Arginine repressor, C-terminal domain; Region: Arg_repressor_C; pfam02863 990317007091 arginyl-tRNA synthetase; Reviewed; Region: PRK12451 990317007092 Arginyl tRNA synthetase N terminal dom; Region: Arg_tRNA_synt_N; smart01016 990317007093 catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671 990317007094 active site 990317007095 HIGH motif; other site 990317007096 KMSK motif region; other site 990317007097 Anticodon-binding domain of arginyl tRNA synthetases; Region: Anticodon_Ia_Arg; cd07956 990317007098 tRNA binding surface [nucleotide binding]; other site 990317007099 anticodon binding site; other site 990317007100 Enterocin A Immunity; Region: EntA_Immun; pfam08951 990317007101 Predicted peptidase [General function prediction only]; Region: COG4099 990317007102 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 990317007103 Uncharacterized conserved protein [Function unknown]; Region: COG1284 990317007104 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 990317007105 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 990317007106 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 990317007107 Uncharacterized conserved protein [Function unknown]; Region: COG1284 990317007108 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 990317007109 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 990317007110 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 990317007111 aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476 990317007112 EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317 990317007113 dimer interface [polypeptide binding]; other site 990317007114 anticodon binding site; other site 990317007115 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777 990317007116 homodimer interface [polypeptide binding]; other site 990317007117 motif 1; other site 990317007118 active site 990317007119 motif 2; other site 990317007120 GAD domain; Region: GAD; pfam02938 990317007121 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777 990317007122 motif 3; other site 990317007123 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 990317007124 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 990317007125 non-specific DNA binding site [nucleotide binding]; other site 990317007126 salt bridge; other site 990317007127 sequence-specific DNA binding site [nucleotide binding]; other site 990317007128 histidyl-tRNA synthetase; Reviewed; Region: hisS; PRK00037 990317007129 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 990317007130 dimer interface [polypeptide binding]; other site 990317007131 motif 1; other site 990317007132 active site 990317007133 motif 2; other site 990317007134 HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859 990317007135 anticodon binding site; other site 990317007136 50S ribosomal protein L32; Validated; Region: rpmF; PRK01110 990317007137 50S ribosomal protein L33; Validated; Region: rpmG; PRK00595 990317007138 Tn1545-related conjugative transposon integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes bacterial (gram positive) and phage integrases, including those similar to Tn1545, Tn5252, and...; Region: INT_Tn1545_C; cd01199 990317007139 Int/Topo IB signature motif; other site 990317007140 Sortase A (SrtA) or subfamily-1 sortases are cysteine transpeptidases found in gram-positive bacteria that anchor surface proteins to peptidoglycans of the bacterial cell wall envelope. They do so by catalyzing a transpeptidation reaction in which the...; Region: Sortase_A_1; cd06165 990317007141 active site 990317007142 catalytic site [active] 990317007143 CHAP domain; Region: CHAP; pfam05257 990317007144 Cobalamin biosynthesis protein CobT (nicotinate-mononucleotide:5, 6-dimethylbenzimidazole phosphoribosyltransferase) [Coenzyme metabolism]; Region: CobT; COG4547 990317007145 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 990317007146 AAA-like domain; Region: AAA_10; pfam12846 990317007147 TcpE family; Region: TcpE; pfam12648 990317007148 Conjugative transposon protein TcpC; Region: TpcC; pfam12642 990317007149 tRNA synthetases class II (A); Region: tRNA-synt_2c; pfam01411 990317007150 Antirestriction protein (ArdA); Region: ArdA; cl01953 990317007151 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 990317007152 non-specific DNA binding site [nucleotide binding]; other site 990317007153 salt bridge; other site 990317007154 sequence-specific DNA binding site [nucleotide binding]; other site 990317007155 Replication initiation factor; Region: Rep_trans; pfam02486 990317007156 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 990317007157 GNS1/SUR4 family; Region: ELO; cl03120 990317007158 putative cross-wall-targeting lipoprotein signal; Region: strep_RK_lipo; TIGR03726 990317007159 ATP synthase B/B' CF(0); Region: ATP-synt_B; pfam00430 990317007160 Glucan-binding protein C; Region: GbpC; pfam08363 990317007161 LPXTG-motif cell wall anchor domain; Region: LPXTG_anchor; TIGR01167 990317007162 conjugal transfer protein TrbB; Provisional; Region: PRK13728; cl17283 990317007163 Protein of unknown function DUF86; Region: DUF86; cl01031 990317007164 Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403 990317007165 active site 990317007166 NTP binding site [chemical binding]; other site 990317007167 metal binding triad [ion binding]; metal-binding site 990317007168 antibiotic binding site [chemical binding]; other site 990317007169 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 990317007170 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 990317007171 non-specific DNA binding site [nucleotide binding]; other site 990317007172 salt bridge; other site 990317007173 sequence-specific DNA binding site [nucleotide binding]; other site 990317007174 Domain of unknown function (DUF955); Region: DUF955; pfam06114 990317007175 murein transglycosylase A; Provisional; Region: mltA; PRK11162 990317007176 RelB antitoxin; Region: RelB; cl01171 990317007177 Eco47II restriction endonuclease; Region: RE_Eco47II; pfam09553 990317007178 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315 990317007179 C-5 cytosine-specific DNA methylase; Region: DNA_methylase; pfam00145 990317007180 cofactor binding site; other site 990317007181 DNA binding site [nucleotide binding] 990317007182 substrate interaction site [chemical binding]; other site 990317007183 AAA domain; Region: AAA_28; pfam13521 990317007184 DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674 990317007185 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 990317007186 Plasmid replication protein; Region: Rep_2; pfam01719 990317007187 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 990317007188 phiLC3 phage and phage-related integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes various bacterial (mainly gram positive) and phage integrases, including those similar to Lactococcus...; Region: INT_phiLC3_C; cd01189 990317007189 Int/Topo IB signature motif; other site 990317007190 AAA domain; Region: AAA_21; pfam13304 990317007191 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 990317007192 Walker B; other site 990317007193 D-loop; other site 990317007194 H-loop/switch region; other site 990317007195 Cro/C1-type HTH DNA-binding domain; Region: HTH_26; pfam13443 990317007196 glycosyltransferase family protein; Region: PLN02208 990317007197 DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674 990317007198 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 990317007199 Plasmid replication protein; Region: Rep_2; pfam01719 990317007200 Helix-turn-helix domain; Region: HTH_17; cl17695 990317007201 phiLC3 phage and phage-related integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes various bacterial (mainly gram positive) and phage integrases, including those similar to Lactococcus...; Region: INT_phiLC3_C; cd01189 990317007202 Int/Topo IB signature motif; other site 990317007203 Antibiotic biosynthesis monooxygenase; Region: ABM; pfam03992 990317007204 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 990317007205 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 990317007206 Coenzyme A binding pocket [chemical binding]; other site 990317007207 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 990317007208 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 990317007209 putative DNA binding site [nucleotide binding]; other site 990317007210 dimerization interface [polypeptide binding]; other site 990317007211 putative Zn2+ binding site [ion binding]; other site 990317007212 Predicted transcriptional regulators [Transcription]; Region: COG1695 990317007213 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 990317007214 Predicted membrane protein [Function unknown]; Region: COG4709 990317007215 Domain of unknown function (DUF4097); Region: DUF4097; pfam13349 990317007216 Domain of unknown function (DUF4098); Region: DUF4098; pfam13345 990317007217 Predicted membrane protein [Function unknown]; Region: COG3759 990317007218 Predicted membrane protein [Function unknown]; Region: COG1511 990317007219 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061 990317007220 X-X-X-Leu-X-X-Gly heptad repeats; Region: xxxLxxG_by_4; TIGR03057 990317007221 YhgE/Pip C-terminal domain; Region: pip_yhgE_Cterm; TIGR03062 990317007222 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 990317007223 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 990317007224 30S ribosomal protein S4; Validated; Region: rpsD; PRK05327 990317007225 Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163 990317007226 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 990317007227 RNA binding surface [nucleotide binding]; other site 990317007228 Uncharacterized protein conserved in bacteria [Function unknown]; Region: Veg; COG4466 990317007229 replicative DNA helicase; Provisional; Region: PRK05748 990317007230 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 990317007231 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 990317007232 Walker A motif; other site 990317007233 ATP binding site [chemical binding]; other site 990317007234 Walker B motif; other site 990317007235 DNA binding loops [nucleotide binding] 990317007236 50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137 990317007237 Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281 990317007238 Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948 990317007239 Predicted signaling protein consisting of a modified GGDEF domain and a DHH domain [Signal transduction mechanisms]; Region: COG3887 990317007240 Class III nucleotidyl cyclases; Region: Nucleotidyl_cyc_III; cl11967 990317007241 DHH family; Region: DHH; pfam01368 990317007242 DHHA1 domain; Region: DHHA1; pfam02272 990317007243 tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA; Validated; Region: PRK05192 990317007244 tRNA:m(5)U-54 methyltransferase; Region: gid_trmFO; TIGR00137 990317007245 GidA associated domain 3; Region: GIDA_assoc_3; pfam13932 990317007246 hypothetical protein; Provisional; Region: PRK09273 990317007247 Ribose/Galactose Isomerase; Region: LacAB_rpiB; pfam02502 990317007248 Predicted tRNA(5-methylaminomethyl-2-thiouridylate) methyltransferase, contains the PP-loop ATPase domain [Translation, ribosomal structure and biogenesis]; Region: TrmU; COG0482 990317007249 tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998 990317007250 L-serine dehydratase, iron-sulfur-dependent, beta subunit; Region: sda_beta; TIGR00719 990317007251 Serine dehydratase beta chain; Region: SDH_beta; pfam03315 990317007252 C-terminal ACT domain of the L-serine dehydratase (LSD), iron-sulfur-dependent, beta subunit; Region: ACT_LSD; cd04903 990317007253 putative L-serine binding site [chemical binding]; other site 990317007254 Serine dehydratase alpha chain; Region: SDH_alpha; cl12120 990317007255 L-serine deaminase [Amino acid transport and metabolism]; Region: SdaA; COG1760 990317007256 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 990317007257 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 990317007258 motif II; other site 990317007259 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 990317007260 N-acetyl-D-glucosamine binding site [chemical binding]; other site 990317007261 catalytic residue [active] 990317007262 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 990317007263 ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619 990317007264 cobalt transporter ATP-binding subunit; Provisional; Region: cbiO; PRK13649 990317007265 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 990317007266 Walker A/P-loop; other site 990317007267 ATP binding site [chemical binding]; other site 990317007268 Q-loop/lid; other site 990317007269 ABC transporter signature motif; other site 990317007270 Walker B; other site 990317007271 D-loop; other site 990317007272 H-loop/switch region; other site 990317007273 cobalt transporter ATP-binding subunit; Provisional; Region: cbiO; PRK13650 990317007274 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 990317007275 Walker A/P-loop; other site 990317007276 ATP binding site [chemical binding]; other site 990317007277 Q-loop/lid; other site 990317007278 ABC transporter signature motif; other site 990317007279 Walker B; other site 990317007280 D-loop; other site 990317007281 H-loop/switch region; other site 990317007282 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453 990317007283 Helix-turn-helix domain; Region: HTH_25; pfam13413 990317007284 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 990317007285 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 990317007286 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 990317007287 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 990317007288 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 990317007289 S4 domain protein YaaA; Region: YaaA_near_RecF; TIGR02988 990317007290 recombination protein F; Reviewed; Region: recF; PRK00064 990317007291 ATP-binding cassette domain of RecF; Region: ABC_RecF; cd03242 990317007292 Walker A/P-loop; other site 990317007293 ATP binding site [chemical binding]; other site 990317007294 Q-loop/lid; other site 990317007295 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 990317007296 ABC transporter signature motif; other site 990317007297 Walker B; other site 990317007298 D-loop; other site 990317007299 H-loop/switch region; other site 990317007300 Putative glucose uptake permease [Carbohydrate transport and metabolism]; Region: GlcU; COG4975 990317007301 inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567 990317007302 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 990317007303 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein. IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a...; Region: CBS_pair_IMPDH; cd04601 990317007304 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 990317007305 active site 990317007306 tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282 990317007307 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 990317007308 active site 990317007309 HIGH motif; other site 990317007310 dimer interface [polypeptide binding]; other site 990317007311 KMSKS motif; other site 990317007312 Uncharacterized conserved protein [Function unknown]; Region: COG1284 990317007313 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 990317007314 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 990317007315 ABC transporter ATP-binding protein; Provisional; Region: PRK15064 990317007316 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 990317007317 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 990317007318 ABC transporter; Region: ABC_tran_2; pfam12848 990317007319 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 990317007320 Predicted membrane protein [Function unknown]; Region: COG4485 990317007321 rRNA large subunit methyltransferase; Provisional; Region: PRK00103 990317007322 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 990317007323 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 990317007324 protein binding site [polypeptide binding]; other site 990317007325 ParB/RepB/Spo0J family partition protein; Region: parB_part; TIGR00180 990317007326 ParB-like nuclease domain; Region: ParBc; pfam02195 990317007327 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 990317007328 Initiator Replication protein; Region: Rep_3; pfam01051 990317007329 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3316 990317007330 Integrase core domain; Region: rve; pfam00665 990317007331 Omega Transcriptional Repressor; Region: Omega_Repress; pfam07764 990317007332 Transposon-encoded protein TnpV; Region: TnpV; pfam14198 990317007333 Translation elongation factors (GTPases) [Translation, ribosomal structure and biogenesis]; Region: FusA; COG0480 990317007334 Tet(M)-like family includes Tet(M), Tet(O), Tet(W), and OtrA, containing tetracycline resistant proteins; Region: TetM_like; cd04168 990317007335 G1 box; other site 990317007336 putative GEF interaction site [polypeptide binding]; other site 990317007337 GTP/Mg2+ binding site [chemical binding]; other site 990317007338 Switch I region; other site 990317007339 G2 box; other site 990317007340 G3 box; other site 990317007341 Switch II region; other site 990317007342 G4 box; other site 990317007343 G5 box; other site 990317007344 Tet_II: This subfamily represents domain II of ribosomal protection proteins Tet(M) and Tet(O). This domain has homology to domain II of the elongation factors EF-G and EF-2. Tet(M) and Tet(O) catalyze the release of tetracycline (Tc) from the ribosome...; Region: Tet_II; cd03690 990317007345 EF-G_domain IV_RPP domain is a part of bacterial ribosomal protected proteins (RPP) family. RPPs such as tetracycline resistance proteins Tet(M) and Tet(O) mediate tetracycline resistance in both gram-positive and -negative species. Tetracyclines inhibit...; Region: Tet_like_IV; cd01684 990317007346 Tet_C: C-terminus of ribosomal protection proteins Tet(M) and Tet(O). This domain has homology to the C terminal domains of the elongation factors EF-G and EF-2. Tet(M) and Tet(O) catalyze the release of tetracycline (Tc) from the ribosome in a...; Region: Tet_C; cd03711 990317007347 Relaxase/Mobilisation nuclease domain; Region: Relaxase; pfam03432 990317007348 Replication protein; Region: Rep_1; pfam01446 990317007349 Tetracycline resistance leader peptide; Region: Tet_res_leader; pfam08050 990317007350 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 990317007351 Major Facilitator Superfamily; Region: MFS_1; pfam07690 990317007352 putative substrate translocation pore; other site 990317007353 Initiator Replication protein; Region: Rep_3; pfam01051 990317007354 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 990317007355 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768 990317007356 catalytic residues [active] 990317007357 catalytic nucleophile [active] 990317007358 Presynaptic Site I dimer interface [polypeptide binding]; other site 990317007359 Synaptic Antiparallel dimer interface [polypeptide binding]; other site 990317007360 Synaptic Flat tetramer interface [polypeptide binding]; other site 990317007361 Synaptic Site I dimer interface [polypeptide binding]; other site 990317007362 Homeodomain-like domain; Region: HTH_23; pfam13384 990317007363 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3316 990317007364 Integrase core domain; Region: rve; pfam00665 990317007365 Initiator Replication protein; Region: Rep_3; pfam01051