-- dump date 20140620_082139 -- class Genbank::misc_feature -- table misc_feature_note -- id note 637909000001 chromosomal replication initiation protein; Reviewed; Region: dnaA; PRK00149 637909000002 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 637909000003 Walker A motif; other site 637909000004 ATP binding site [chemical binding]; other site 637909000005 Walker B motif; other site 637909000006 arginine finger; other site 637909000007 C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571 637909000008 DnaA box-binding interface [nucleotide binding]; other site 637909000009 DNA polymerase III subunit beta; Validated; Region: PRK05643 637909000010 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140 637909000011 putative DNA binding surface [nucleotide binding]; other site 637909000012 dimer interface [polypeptide binding]; other site 637909000013 beta-clamp/clamp loader binding surface; other site 637909000014 beta-clamp/translesion DNA polymerase binding surface; other site 637909000015 Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase [Lipid metabolism / General function prediction only]; Region: LCB5; COG1597 637909000016 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 637909000017 Bacterial protein of unknown function (DUF951); Region: DUF951; pfam06107 637909000018 GTP-binding protein YchF; Reviewed; Region: PRK09601 637909000019 YchF GTPase; Region: YchF; cd01900 637909000020 G1 box; other site 637909000021 GTP/Mg2+ binding site [chemical binding]; other site 637909000022 Switch I region; other site 637909000023 G2 box; other site 637909000024 Switch II region; other site 637909000025 G3 box; other site 637909000026 G4 box; other site 637909000027 G5 box; other site 637909000028 TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867 637909000029 Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462 637909000030 putative active site [active] 637909000031 catalytic residue [active] 637909000032 Transcription-repair coupling factor (superfamily II helicase) [DNA replication, recombination, and repair / Transcription]; Region: Mfd; COG1197 637909000033 CarD-like/TRCF domain; Region: CarD_TRCF; smart01058 637909000034 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 637909000035 ATP binding site [chemical binding]; other site 637909000036 putative Mg++ binding site [ion binding]; other site 637909000037 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 637909000038 nucleotide binding region [chemical binding]; other site 637909000039 ATP-binding site [chemical binding]; other site 637909000040 This domain is found in proteins necessary for strand-specific repair in DNA such as TRCF in Escherichia coli; Region: TRCF; smart00982 637909000041 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 637909000042 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 637909000043 non-specific DNA binding site [nucleotide binding]; other site 637909000044 sequence-specific DNA binding site [nucleotide binding]; other site 637909000045 salt bridge; other site 637909000046 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 637909000047 RNA binding surface [nucleotide binding]; other site 637909000048 Septum formation initiator [Cell division and chromosome partitioning]; Region: COG2919 637909000049 Septum formation initiator; Region: DivIC; pfam04977 637909000050 Beta-lactamase class A [Defense mechanisms]; Region: PenP; COG2367 637909000051 Beta-lactamase enzyme family; Region: Beta-lactamase2; pfam13354 637909000052 tRNA(Ile)-lysidine synthase MesJ [Cell cycle control, cell division, chromosome partitioning]; Region: MesJ; COG0037 637909000053 N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992 637909000054 Ligand Binding Site [chemical binding]; other site 637909000055 TilS substrate C-terminal domain; Region: TilS_C; smart00977 637909000056 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 637909000057 active site 637909000058 ATP-dependent Zn proteases [Posttranslational modification, protein turnover, chaperones]; Region: HflB; COG0465 637909000059 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 637909000060 Walker A motif; other site 637909000061 ATP binding site [chemical binding]; other site 637909000062 Walker B motif; other site 637909000063 arginine finger; other site 637909000064 Peptidase family M41; Region: Peptidase_M41; pfam01434 637909000065 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3666 637909000066 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 637909000067 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 637909000068 rod shape-determining protein MreC; Provisional; Region: PRK13922 637909000069 rod shape-determining protein MreC; Region: MreC; pfam04085 637909000070 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3883 637909000071 CHAP domain; Region: CHAP; pfam05257 637909000072 Surface antigen [General function prediction only]; Region: COG3942 637909000073 ribose-phosphate pyrophosphokinase; Provisional; Region: PRK02269 637909000074 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 637909000075 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 637909000076 active site 637909000077 aromatic amino acid aminotransferase; Validated; Region: PRK07309 637909000078 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 637909000079 pyridoxal 5'-phosphate binding site [chemical binding]; other site 637909000080 homodimer interface [polypeptide binding]; other site 637909000081 catalytic residue [active] 637909000082 Recombination protein O N terminal; Region: RecO_N; pfam11967 637909000083 DNA repair protein RecO; Region: reco; TIGR00613 637909000084 Recombination protein O C terminal; Region: RecO_C; pfam02565 637909000085 putative phosphate acyltransferase; Provisional; Region: PRK05331 637909000086 acyl carrier protein; Provisional; Region: PRK12449 637909000087 phosphoribosylaminoimidazole-succinocarboxamide synthase; Reviewed; Region: PRK09362 637909000088 bacterial and archaeal 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_PurC; cd01415 637909000089 ATP binding site [chemical binding]; other site 637909000090 active site 637909000091 substrate binding site [chemical binding]; other site 637909000092 phosphoribosylformylglycinamidine synthase, clade II; Region: FGAM-synthase; TIGR01857 637909000093 AIR (aminoimidazole ribonucleotide) synthase related protein. This family includes Hydrogen expression/formation protein HypE, AIR synthases, FGAM (formylglycinamidine ribonucleotide) synthase and Selenophosphate synthetase (SelD). The N-terminal domain...; Region: PurM-like; cl10019 637909000094 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203 637909000095 dimerization interface [polypeptide binding]; other site 637909000096 ATP binding site [chemical binding]; other site 637909000097 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat2; cd02204 637909000098 dimerization interface [polypeptide binding]; other site 637909000099 ATP binding site [chemical binding]; other site 637909000100 Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740 637909000101 putative active site [active] 637909000102 catalytic triad [active] 637909000103 amidophosphoribosyltransferase; Provisional; Region: PRK07272 637909000104 Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715 637909000105 active site 637909000106 tetramer interface [polypeptide binding]; other site 637909000107 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 637909000108 active site 637909000109 phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385 637909000110 PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196 637909000111 dimerization interface [polypeptide binding]; other site 637909000112 putative ATP binding site [chemical binding]; other site 637909000113 phosphoribosylglycinamide formyltransferase; Reviewed; Region: purN; PRK05647 637909000114 Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645 637909000115 active site 637909000116 substrate binding site [chemical binding]; other site 637909000117 cosubstrate binding site; other site 637909000118 catalytic site [active] 637909000119 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 637909000120 Coenzyme A binding pocket [chemical binding]; other site 637909000121 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881 637909000122 Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal ATIC formylase domain that formylates...; Region: IMPCH; cd01421 637909000123 purine monophosphate binding site [chemical binding]; other site 637909000124 dimer interface [polypeptide binding]; other site 637909000125 putative catalytic residues [active] 637909000126 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; smart00798 637909000127 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; cl03362 637909000128 phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885 637909000129 Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844 637909000130 Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Region: GARS_A; pfam01071 637909000131 Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843 637909000132 Protein of unknown function (DUF523); Region: DUF523; pfam04463 637909000133 Phosphoribosylcarboxyaminoimidazole (NCAIR) mutase [Nucleotide transport and metabolism]; Region: PurE; COG0041 637909000134 phosphoribosylaminoimidazole carboxylase ATPase subunit; Reviewed; Region: PRK06019 637909000135 ATP-grasp domain; Region: ATP-grasp; pfam02222 637909000136 poly-beta-1,6 N-acetyl-D-glucosamine synthase; Region: PgaC_IcaA; TIGR03937 637909000137 adenylosuccinate lyase; Provisional; Region: PRK07492 637909000138 Adenylsuccinate lyase (ASL)_subgroup 1; Region: Adenylsuccinate_lyase_1; cd01360 637909000139 tetramer interface [polypeptide binding]; other site 637909000140 active site 637909000141 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 637909000142 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 637909000143 non-specific DNA binding site [nucleotide binding]; other site 637909000144 salt bridge; other site 637909000145 sequence-specific DNA binding site [nucleotide binding]; other site 637909000146 Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394 637909000147 Low molecular weight phosphatase family; Region: LMWPc; cd00115 637909000148 active site 637909000149 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4642 637909000150 MORN repeat; Region: MORN; cl14787 637909000151 Acyltransferase family; Region: Acyl_transf_3; pfam01757 637909000152 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053 637909000153 active site 637909000154 catalytic triad [active] 637909000155 oxyanion hole [active] 637909000156 Threonine synthase catalyzes the final step of threonine biosynthesis. The conversion of O-phosphohomoserine into threonine and inorganic phosphate is pyridoxal 5'-phosphate dependent. The Thr-synth_1 CD includes members from higher plants; Region: Thr-synth_2; cd01560 637909000157 Threonine synthase [Amino acid transport and metabolism]; Region: ThrC; COG0498 637909000158 pyridoxal 5'-phosphate binding site [chemical binding]; other site 637909000159 catalytic residue [active] 637909000160 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 637909000161 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Thermotoga marina NorM; Region: MATE_NorM_like; cd13137 637909000162 MMPL family; Region: MMPL; pfam03176 637909000163 MMPL family; Region: MMPL; pfam03176 637909000164 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 637909000165 Histidine kinase; Region: HisKA_3; pfam07730 637909000166 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 637909000167 ATP binding site [chemical binding]; other site 637909000168 Mg2+ binding site [ion binding]; other site 637909000169 G-X-G motif; other site 637909000170 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 637909000171 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 637909000172 active site 637909000173 phosphorylation site [posttranslational modification] 637909000174 intermolecular recognition site; other site 637909000175 dimerization interface [polypeptide binding]; other site 637909000176 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 637909000177 DNA binding residues [nucleotide binding] 637909000178 dimerization interface [polypeptide binding]; other site 637909000179 Transcriptional regulator [Transcription]; Region: LysR; COG0583 637909000180 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 637909000181 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 637909000182 dimerization interface [polypeptide binding]; other site 637909000183 30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596 637909000184 50S ribosomal protein L3; Validated; Region: rplC; PRK00001 637909000185 50S ribosomal protein L4; Provisional; Region: rplD; PRK05319 637909000186 50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738 637909000187 50S ribosomal protein L2; Validated; Region: rplB; PRK09374 637909000188 Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181 637909000189 Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947 637909000190 30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357 637909000191 Ribosomal protein L22/L17e. L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit. It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336 637909000192 putative translocon binding site; other site 637909000193 protein-rRNA interface [nucleotide binding]; other site 637909000194 30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310 637909000195 K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3 is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel. The KH...; Region: 30S_S3_KH; cd02412 637909000196 G-X-X-G motif; other site 637909000197 Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189 637909000198 Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433 637909000199 23S rRNA interface [nucleotide binding]; other site 637909000200 5S rRNA interface [nucleotide binding]; other site 637909000201 putative antibiotic binding site [chemical binding]; other site 637909000202 L25 interface [polypeptide binding]; other site 637909000203 L27 interface [polypeptide binding]; other site 637909000204 Ribosomal L29 protein/HIP. L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals. L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427 637909000205 23S rRNA interface [nucleotide binding]; other site 637909000206 putative translocon interaction site; other site 637909000207 signal recognition particle (SRP54) interaction site; other site 637909000208 L23 interface [polypeptide binding]; other site 637909000209 trigger factor interaction site; other site 637909000210 30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610 637909000211 50S ribosomal protein L14; Validated; Region: rplN; PRK05483 637909000212 50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004 637909000213 KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089 637909000214 RNA binding site [nucleotide binding]; other site 637909000215 50S ribosomal protein L5; Validated; Region: rplE; PRK00010 637909000216 Ribosomal protein L5; Region: Ribosomal_L5; pfam00281 637909000217 ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673 637909000218 30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08061 637909000219 30S ribosomal protein S8; Validated; Region: rpsH; PRK00136 637909000220 50S ribosomal protein L6; Validated; Region: rplF; PRK05498 637909000221 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 637909000222 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 637909000223 Ribosomal L18/L5e: L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432 637909000224 5S rRNA interface [nucleotide binding]; other site 637909000225 L27 interface [polypeptide binding]; other site 637909000226 23S rRNA interface [nucleotide binding]; other site 637909000227 L5 interface [polypeptide binding]; other site 637909000228 30S ribosomal protein S5; Validated; Region: rpsE; PRK00550 637909000229 Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333 637909000230 Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719 637909000231 Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins that...; Region: Ribosomal_L30; cd01658 637909000232 23S rRNA binding site [nucleotide binding]; other site 637909000233 50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592 637909000234 preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204 637909000235 SecY translocase; Region: SecY; pfam00344 637909000236 adenylate kinase; Reviewed; Region: adk; PRK00279 637909000237 Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428 637909000238 AMP-binding site [chemical binding]; other site 637909000239 ATP-AMP (Ap5A)-binding site [chemical binding]; other site 637909000240 S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451 637909000241 rRNA binding site [nucleotide binding]; other site 637909000242 predicted 30S ribosome binding site; other site 637909000243 Ribosomal protein L36; Region: Ribosomal_L36; pfam00444 637909000244 Ribosomal protein S13 [Translation, ribosomal structure and biogenesis]; Region: RpsM; COG0099 637909000245 30S ribosomal protein S13; Region: bact_S13; TIGR03631 637909000246 30S ribosomal protein S11; Validated; Region: PRK05309 637909000247 DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182 637909000248 N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928 637909000249 alphaNTD homodimer interface [polypeptide binding]; other site 637909000250 alphaNTD - beta interaction site [polypeptide binding]; other site 637909000251 alphaNTD - beta' interaction site [polypeptide binding]; other site 637909000252 Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118 637909000253 50S ribosomal protein L17; Validated; Region: rplQ; PRK05591 637909000254 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: ipk; PRK00128 637909000255 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 637909000256 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 637909000257 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 637909000258 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 637909000259 putative Zn2+ binding site [ion binding]; other site 637909000260 putative DNA binding site [nucleotide binding]; other site 637909000261 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 637909000262 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 637909000263 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 637909000264 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 637909000265 ABC-ATPase subunit interface; other site 637909000266 dimer interface [polypeptide binding]; other site 637909000267 putative PBP binding regions; other site 637909000268 tyrosyl-tRNA synthetase; Validated; Region: PRK05912 637909000269 catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805 637909000270 active site 637909000271 HIGH motif; other site 637909000272 dimer interface [polypeptide binding]; other site 637909000273 KMSKS motif; other site 637909000274 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 637909000275 RNA binding surface [nucleotide binding]; other site 637909000276 Membrane carboxypeptidase (penicillin-binding protein) [Cell envelope biogenesis, outer membrane]; Region: MrcB; COG0744 637909000277 Transglycosylase; Region: Transgly; pfam00912 637909000278 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 637909000279 DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405 637909000280 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585 637909000281 RNA polymerase Rpb2, domain 2; Region: RNA_pol_Rpb2_2; pfam04561 637909000282 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 637909000283 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 637909000284 RPB1 interaction site [polypeptide binding]; other site 637909000285 RPB12 interaction site [polypeptide binding]; other site 637909000286 RPB10 interaction site [polypeptide binding]; other site 637909000287 RPB11 interaction site [polypeptide binding]; other site 637909000288 RPB3 interaction site [polypeptide binding]; other site 637909000289 RPB12 interaction site [polypeptide binding]; other site 637909000290 DNA-directed RNA polymerase subunit beta'; Provisional; Region: PRK00566 637909000291 RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997 637909000292 RNA polymerase I subunit A N-terminus; Region: RPOLA_N; smart00663 637909000293 RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983 637909000294 RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000 637909000295 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 637909000296 Rpb1 (beta') - Rpb6 (omega) interaction site [polypeptide binding]; other site 637909000297 G-loop; other site 637909000298 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 637909000299 DNA binding site [nucleotide binding] 637909000300 Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site 637909000301 Protein of unknown function (DUF1033); Region: DUF1033; pfam06279 637909000302 Type II/IV secretion system protein; Region: T2SE; pfam00437 637909000303 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 637909000304 Walker A motif; other site 637909000305 ATP binding site [chemical binding]; other site 637909000306 Walker B motif; other site 637909000307 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 637909000308 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 637909000309 Competence protein ComGC [Intracellular trafficking and secretion]; Region: ComGC; COG4537 637909000310 Type II secretory pathway, pseudopilin PulG [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulG; COG2165 637909000311 Type II secretory pathway pseudopilin; Region: PulG; pfam11773 637909000312 Competence protein ComGF [Intracellular trafficking and secretion]; Region: ComGF; COG4940 637909000313 Methyltransferase domain; Region: Methyltransf_31; pfam13847 637909000314 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 637909000315 S-adenosylmethionine binding site [chemical binding]; other site 637909000316 acetate kinase A/propionate kinase 2; Reviewed; Region: PRK00180 637909000317 propionate/acetate kinase; Provisional; Region: PRK12379 637909000318 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 637909000319 non-specific DNA binding site [nucleotide binding]; other site 637909000320 salt bridge; other site 637909000321 sequence-specific DNA binding site [nucleotide binding]; other site 637909000322 CAAX protease self-immunity; Region: Abi; pfam02517 637909000323 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232 637909000324 pyrroline-5-carboxylate reductase; Reviewed; Region: PRK11880 637909000325 Cellulase M and related proteins [Carbohydrate transport and metabolism]; Region: FrvX; COG1363 637909000326 glutamyl aminopeptidase; Region: glu_aminopep; TIGR03107 637909000327 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 637909000328 catalytic residues [active] 637909000329 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 637909000330 putative tRNA-binding site [nucleotide binding]; other site 637909000331 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 637909000332 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 637909000333 dimer interface [polypeptide binding]; other site 637909000334 ssDNA binding site [nucleotide binding]; other site 637909000335 tetramer (dimer of dimers) interface [polypeptide binding]; other site 637909000336 putative selenium metabolism protein, YedE family; Region: seleno_YedE; TIGR04112 637909000337 Sulphur transport; Region: Sulf_transp; pfam04143 637909000338 SirA, YedF, and YeeD. Two-layered alpha/beta sandwich domain. SirA (also known as UvrY, and YhhP) belongs to a family of bacterial two-component response regulators that controls secondary metabolism and virulence. The other member of this...; Region: SirA_YedF_YeeD; cd00291 637909000339 CPxP motif; other site 637909000340 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 637909000341 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 637909000342 active site 637909000343 motif I; other site 637909000344 motif II; other site 637909000345 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 637909000346 Sporulation related domain; Region: SPOR; cl10051 637909000347 Cadherin-like beta sandwich domain; Region: Cadherin-like; pfam12733 637909000348 Glycosyl hydrolases family 32; Region: Glyco_32; smart00640 637909000349 Glycosyl hydrolase family 32, beta-fructosidases; Region: GH32_B_Fructosidase; cd08996 637909000350 substrate binding [chemical binding]; other site 637909000351 active site 637909000352 Glycosyl hydrolases family 32 C terminal; Region: Glyco_hydro_32C; pfam08244 637909000353 Laminin G domain; Region: Laminin_G_2; pfam02210 637909000354 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: RbsB; COG1879 637909000355 Periplasmic sugar-binding domain of active transport systems that are members of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_sugar_binding_like; cd01536 637909000356 ligand binding site [chemical binding]; other site 637909000357 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 637909000358 Histidine kinase; Region: HisKA_3; pfam07730 637909000359 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 637909000360 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 637909000361 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 637909000362 active site 637909000363 phosphorylation site [posttranslational modification] 637909000364 intermolecular recognition site; other site 637909000365 dimerization interface [polypeptide binding]; other site 637909000366 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 637909000367 DNA binding residues [nucleotide binding] 637909000368 dimerization interface [polypeptide binding]; other site 637909000369 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 637909000370 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 637909000371 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cl00025 637909000372 active pocket/dimerization site; other site 637909000373 active site 637909000374 phosphorylation site [posttranslational modification] 637909000375 PTS_IIB, PTS system, Mannose/sorbose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_man; cl00021 637909000376 active site 637909000377 phosphorylation site [posttranslational modification] 637909000378 PTS system sorbose-specific iic component; Region: EII-Sor; pfam03609 637909000379 PTS system mannose/fructose/sorbose family IID component; Region: EIID-AGA; pfam03613 637909000380 Domain of unknown function (DUF4191); Region: DUF4191; pfam13829 637909000381 Type I periplasmic ligand-binding domain of uncharacterized ABC-type transport systems that are predicted to be involved in the uptake of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_uncharacterized_transporter; cd06325 637909000382 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 637909000383 zinc binding site [ion binding]; other site 637909000384 putative ligand binding site [chemical binding]; other site 637909000385 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 637909000386 Transmembrane subunit (TM) of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which are involved in the uptake of branched-chain amino acids (AAs), as well as TMs of transporters involved in the uptake of...; Region: TM_PBP1_branched-chain-AA_like; cd06574 637909000387 TM-ABC transporter signature motif; other site 637909000388 ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: PhnK; COG1101 637909000389 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 637909000390 Walker A/P-loop; other site 637909000391 ATP binding site [chemical binding]; other site 637909000392 Q-loop/lid; other site 637909000393 ABC transporter signature motif; other site 637909000394 Walker B; other site 637909000395 D-loop; other site 637909000396 H-loop/switch region; other site 637909000397 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 637909000398 oligomerisation interface [polypeptide binding]; other site 637909000399 mobile loop; other site 637909000400 roof hairpin; other site 637909000401 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 637909000402 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 637909000403 ring oligomerisation interface [polypeptide binding]; other site 637909000404 ATP/Mg binding site [chemical binding]; other site 637909000405 stacking interactions; other site 637909000406 hinge regions; other site 637909000407 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 637909000408 non-specific DNA binding site [nucleotide binding]; other site 637909000409 salt bridge; other site 637909000410 sequence-specific DNA binding site [nucleotide binding]; other site 637909000411 transcriptional activator, Rgg/GadR/MutR family, C-terminal domain; Region: RGG_Cterm; TIGR01716 637909000412 Predicted membrane protein [Function unknown]; Region: COG4640 637909000413 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 637909000414 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 637909000415 active site 637909000416 Transglycosylase; Region: Transgly; pfam00912 637909000417 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 637909000418 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 637909000419 50S ribosomal protein L33; Validated; Region: rpmG; PRK00504 637909000420 Preprotein translocase subunit SecE [Intracellular trafficking and secretion]; Region: SecE; COG0690 637909000421 transcription antitermination protein NusG; Validated; Region: nusG; PRK05609 637909000422 Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891 637909000423 putative homodimer interface [polypeptide binding]; other site 637909000424 NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091 637909000425 heterodimer interface [polypeptide binding]; other site 637909000426 homodimer interface [polypeptide binding]; other site 637909000427 Ion transport protein; Region: Ion_trans; pfam00520 637909000428 Ion channel; Region: Ion_trans_2; pfam07885 637909000429 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: COG4667 637909000430 Hypothetical patatin similar to yjju protein of Escherichia coli; Region: Pat_hypo_Ecoli_yjju_like; cd07208 637909000431 active site 637909000432 nucleophile elbow; other site 637909000433 leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390 637909000434 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 637909000435 HIGH motif; other site 637909000436 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 637909000437 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 637909000438 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 637909000439 active site 637909000440 KMSKS motif; other site 637909000441 Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958 637909000442 tRNA binding surface [nucleotide binding]; other site 637909000443 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 637909000444 galactose mutarotase_like; Region: galactose_mutarotase_like; cd09019 637909000445 active site 637909000446 catalytic residues [active] 637909000447 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 637909000448 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 637909000449 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 637909000450 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 637909000451 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 637909000452 recombination factor protein RarA; Reviewed; Region: PRK13342 637909000453 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 637909000454 Walker A motif; other site 637909000455 ATP binding site [chemical binding]; other site 637909000456 Walker B motif; other site 637909000457 arginine finger; other site 637909000458 MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002 637909000459 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 637909000460 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 637909000461 Coenzyme A binding pocket [chemical binding]; other site 637909000462 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 637909000463 Protein of unknown function (DUF3013); Region: DUF3013; pfam11217 637909000464 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 637909000465 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 637909000466 Coenzyme A binding pocket [chemical binding]; other site 637909000467 GNAT acetyltransferase 2; Region: GNAT_acetyltr_2; pfam13718 637909000468 Ribosomal protein L11 methyltransferase (PrmA); Region: PrmA; pfam06325 637909000469 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 637909000470 S-adenosylmethionine binding site [chemical binding]; other site 637909000471 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1385 637909000472 RNA methyltransferase, RsmE family; Region: TIGR00046 637909000473 Transcriptional regulators [Transcription]; Region: PurR; COG1609 637909000474 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 637909000475 DNA binding site [nucleotide binding] 637909000476 domain linker motif; other site 637909000477 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 637909000478 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 637909000479 PTS system, IIBC component; Region: PTS-II-BC-unk1; TIGR02003 637909000480 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 637909000481 active site turn [active] 637909000482 phosphorylation site [posttranslational modification] 637909000483 Phosphotransferase system IIA components [Carbohydrate transport and metabolism]; Region: NagE; COG2190 637909000484 HPr interaction site; other site 637909000485 glycerol kinase (GK) interaction site [polypeptide binding]; other site 637909000486 active site 637909000487 phosphorylation site [posttranslational modification] 637909000488 Streptococcus agalactiae RgfB, part of a putative two component signal transduction system, and related proteins; Region: RgfB-like; cd09079 637909000489 putative catalytic site [active] 637909000490 putative metal binding site [ion binding]; other site 637909000491 putative phosphate binding site [ion binding]; other site 637909000492 Cellulase M and related proteins [Carbohydrate transport and metabolism]; Region: FrvX; COG1363 637909000493 M42 Peptidase, Endoglucanase-like subfamily; Region: M42_glucanase_like; cd05657 637909000494 putative oligomer interface [polypeptide binding]; other site 637909000495 putative active site [active] 637909000496 metal binding site [ion binding]; metal-binding site 637909000497 flavoprotein NrdI; Provisional; Region: PRK02551 637909000498 cellobiose phosphotransferase system IIB component; Reviewed; Region: celB; PRK09590 637909000499 active site 637909000500 P-loop; other site 637909000501 phosphorylation site [posttranslational modification] 637909000502 PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_lac; cd00215 637909000503 methionine cluster; other site 637909000504 active site 637909000505 phosphorylation site [posttranslational modification] 637909000506 metal binding site [ion binding]; metal-binding site 637909000507 Beta-glucosidase/6-phospho-beta-glucosidase/beta- galactosidase [Carbohydrate transport and metabolism]; Region: BglB; COG2723 637909000508 beta-galactosidase; Region: BGL; TIGR03356 637909000509 Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455 637909000510 cellobiose phosphotransferase system IIC component; Reviewed; Region: celD; PRK09592 637909000511 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 637909000512 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 637909000513 DNA-binding site [nucleotide binding]; DNA binding site 637909000514 The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; Region: UTRA; smart00866 637909000515 Phosphomannose isomerase [Carbohydrate transport and metabolism]; Region: ManA; COG1482 637909000516 mannose-6-phosphate isomerase, class I; Region: manA; TIGR00218 637909000517 Aspartate alpha-decarboxylase or L-aspartate 1-decarboxylase, a pyruvoyl group-dependent decarboxylase in beta-alanine production; Region: Asp_decarbox; cd06919 637909000518 tetramerization interface [polypeptide binding]; other site 637909000519 active site 637909000520 Pantoate-beta-alanine ligase; Region: PanC; cd00560 637909000521 pantoate--beta-alanine ligase; Region: panC; TIGR00018 637909000522 active site 637909000523 ATP-binding site [chemical binding]; other site 637909000524 pantoate-binding site; other site 637909000525 HXXH motif; other site 637909000526 Ketopantoate hydroxymethyltransferase (KPHMT) is the first enzyme in the pantothenate biosynthesis pathway. Ketopantoate hydroxymethyltransferase (KPHMT) catalyzes the first committed step in the biosynthesis of pantothenate (vitamin B5), which is a...; Region: KPHMT-like; cd06557 637909000527 oligomerization interface [polypeptide binding]; other site 637909000528 active site 637909000529 metal binding site [ion binding]; metal-binding site 637909000530 Ricin-type beta-trefoil lectin domain; Region: Ricin_B_lectin; pfam00652 637909000531 Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific...; Region: RICIN; cd00161 637909000532 putative sugar binding sites [chemical binding]; other site 637909000533 Q-X-W motif; other site 637909000534 Cellulase (glycosyl hydrolase family 5); Region: Cellulase; pfam00150 637909000535 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 637909000536 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 637909000537 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 637909000538 dimer interface [polypeptide binding]; other site 637909000539 conserved gate region; other site 637909000540 putative PBP binding loops; other site 637909000541 ABC-ATPase subunit interface; other site 637909000542 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 637909000543 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 637909000544 dimer interface [polypeptide binding]; other site 637909000545 conserved gate region; other site 637909000546 ABC-ATPase subunit interface; other site 637909000547 Alpha-galactosidase [Carbohydrate transport and metabolism]; Region: GalA; COG3345 637909000548 Melibiase; Region: Melibiase; pfam02065 637909000549 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 637909000550 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 637909000551 DNA-binding site [nucleotide binding]; DNA binding site 637909000552 The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; Region: UTRA; smart00866 637909000553 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 637909000554 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 637909000555 nucleotide binding site [chemical binding]; other site 637909000556 SGNH_hydrolase subfamily. SGNH hydrolases are a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site...; Region: SGNH_hydrolase_like_2; cd01834 637909000557 active site 637909000558 catalytic triad [active] 637909000559 oxyanion hole [active] 637909000560 Acetyl xylan esterase (AXE1); Region: AXE1; pfam05448 637909000561 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 637909000562 HD domain; Region: HD_4; pfam13328 637909000563 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 637909000564 synthetase active site [active] 637909000565 NTP binding site [chemical binding]; other site 637909000566 metal binding site [ion binding]; metal-binding site 637909000567 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 637909000568 ACT domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876 637909000569 D-Tyrosyl-tRNAtyr deacylases; a class of tRNA-dependent hydrolases which are capable of hydrolyzing the ester bond of D-Tyrosyl-tRNA reducing the level of cellular D-Tyrosine while recycling the peptidyl-tRNA; found in bacteria and in eukaryotes but not...; Region: Dtyr_deacylase; cd00563 637909000570 putative active site [active] 637909000571 dimerization interface [polypeptide binding]; other site 637909000572 putative tRNAtyr binding site [nucleotide binding]; other site 637909000573 Regulator of polyketide synthase expression [Signal transduction mechanisms / Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2508 637909000574 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 637909000575 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 637909000576 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 637909000577 Walker A/P-loop; other site 637909000578 ATP binding site [chemical binding]; other site 637909000579 Q-loop/lid; other site 637909000580 ABC transporter signature motif; other site 637909000581 Walker B; other site 637909000582 D-loop; other site 637909000583 H-loop/switch region; other site 637909000584 TOBE domain; Region: TOBE_2; pfam08402 637909000585 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 637909000586 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 637909000587 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 637909000588 Ribose/Galactose Isomerase; Region: LacAB_rpiB; cl00485 637909000589 galactose-6-phosphate isomerase subunit LacB; Reviewed; Region: PRK08622 637909000590 1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164 637909000591 tagatose-6-phosphate kinase; Region: lacC; TIGR01231 637909000592 putative substrate binding site [chemical binding]; other site 637909000593 putative ATP binding site [chemical binding]; other site 637909000594 tagatose 1,6-diphosphate aldolase; Reviewed; Region: PRK12399 637909000595 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 637909000596 active site 637909000597 phosphorylation site [posttranslational modification] 637909000598 Phosphotransferase system, galactitol-specific IIB component [Carbohydrate transport and metabolism]; Region: SgaB; COG3414 637909000599 active site 637909000600 P-loop; other site 637909000601 phosphorylation site [posttranslational modification] 637909000602 Phosphotransferase system, galactitol-specific IIC component [Carbohydrate transport and metabolism]; Region: GatC; COG3775 637909000603 PTS system sugar-specific permease component; Region: EIIC-GAT; pfam03611 637909000604 Aldose 1-epimerase, similar to Lactococcus lactis lacX; Region: Aldose_epim_lacX; cd09024 637909000605 active site 637909000606 catalytic residues [active] 637909000607 transcriptional antiterminator BglG; Provisional; Region: PRK09772 637909000608 CAT RNA binding domain; Region: CAT_RBD; smart01061 637909000609 PRD domain; Region: PRD; pfam00874 637909000610 PRD domain; Region: PRD; pfam00874 637909000611 6-phospho-beta-galactosidase; Provisional; Region: PRK13511 637909000612 beta-galactosidase; Region: BGL; TIGR03356 637909000613 PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_lac; cd00215 637909000614 methionine cluster; other site 637909000615 active site 637909000616 phosphorylation site [posttranslational modification] 637909000617 metal binding site [ion binding]; metal-binding site 637909000618 Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; cl17295 637909000619 Phosphotransferase system, EIIC; Region: PTS_EIIC; pfam02378 637909000620 PTS_IIB: subunit IIB of enzyme II (EII) is the central energy-coupling domain of the phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In the multienzyme PTS complex, EII is a carbohydrate-specific permease consisting of two cytoplasmic...; Region: PTS_IIB; cl10014 637909000621 active site 637909000622 P-loop; other site 637909000623 phosphorylation site [posttranslational modification] 637909000624 Glycosyl hydrolase family 53; Region: Glyco_hydro_53; cl06672 637909000625 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 637909000626 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 637909000627 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 637909000628 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 637909000629 Alpha-galactosidase [Carbohydrate transport and metabolism]; Region: GalA; COG3345 637909000630 Melibiase; Region: Melibiase; pfam02065 637909000631 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 637909000632 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 637909000633 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 637909000634 dimer interface [polypeptide binding]; other site 637909000635 conserved gate region; other site 637909000636 putative PBP binding loops; other site 637909000637 ABC-ATPase subunit interface; other site 637909000638 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 637909000639 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 637909000640 dimer interface [polypeptide binding]; other site 637909000641 conserved gate region; other site 637909000642 putative PBP binding loops; other site 637909000643 ABC-ATPase subunit interface; other site 637909000644 sucrose phosphorylase; Region: sucrose_gtfA; TIGR03852 637909000645 Alpha amylase catalytic domain found in sucrose phosphorylase (also called sucrose glucosyltransferase, disaccharide glucosyltransferase, and sucrose-phosphate alpha-D glucosyltransferase); Region: AmyAc_Sucrose_phosphorylase; cd11355 637909000646 active site 637909000647 homodimer interface [polypeptide binding]; other site 637909000648 catalytic site [active] 637909000649 alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403 637909000650 Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333 637909000651 Ca binding site [ion binding]; other site 637909000652 active site 637909000653 catalytic site [active] 637909000654 Domain of unknown function (DUF3459); Region: DUF3459; pfam11941 637909000655 DNA-binding transcriptional repressor EbgR; Provisional; Region: PRK10339 637909000656 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 637909000657 DNA binding site [nucleotide binding] 637909000658 Ligand-binding domain of DNA transcription repressor GalR which is one of two regulatory proteins involved in galactose transport and metabolism; Region: PBP1_GalR; cd01544 637909000659 putative dimerization interface [polypeptide binding]; other site 637909000660 putative ligand binding site [chemical binding]; other site 637909000661 galactokinase; Provisional; Region: PRK05322 637909000662 Galactokinase galactose-binding signature; Region: GalKase_gal_bdg; pfam10509 637909000663 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 637909000664 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 637909000665 galactose-1-phosphate uridylyltransferase; Provisional; Region: PRK05270 637909000666 Galactose-1-phosphate uridyl transferase, N-terminal domain; Region: GalP_UDP_transf; pfam01087 637909000667 Galactose-1-phosphate uridyl transferase, C-terminal domain; Region: GalP_UDP_tr_C; pfam02744 637909000668 UDP-glucose 4-epimerase [Cell envelope biogenesis, outer membrane]; Region: GalE; COG1087 637909000669 UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247 637909000670 NAD binding site [chemical binding]; other site 637909000671 homodimer interface [polypeptide binding]; other site 637909000672 active site 637909000673 substrate binding site [chemical binding]; other site 637909000674 mycothiol synthase; Region: mycothiol_MshD; TIGR03448 637909000675 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 637909000676 Coenzyme A binding pocket [chemical binding]; other site 637909000677 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 637909000678 Coenzyme A binding pocket [chemical binding]; other site 637909000679 preprotein translocase subunit YajC; Validated; Region: yajC; PRK06531 637909000680 Undecaprenyl pyrophosphate synthase [Lipid metabolism]; Region: UppS; COG0020 637909000681 Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cd00475 637909000682 catalytic residue [active] 637909000683 putative FPP diphosphate binding site; other site 637909000684 putative FPP binding hydrophobic cleft; other site 637909000685 dimer interface [polypeptide binding]; other site 637909000686 putative IPP diphosphate binding site; other site 637909000687 CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575 637909000688 Cytidylyltransferase family; Region: CTP_transf_1; pfam01148 637909000689 RIP metalloprotease RseP; Region: TIGR00054 637909000690 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 637909000691 active site 637909000692 Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020 637909000693 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 637909000694 protein binding site [polypeptide binding]; other site 637909000695 Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020 637909000696 Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020 637909000697 putative substrate binding region [chemical binding]; other site 637909000698 putative substrate binding region [chemical binding]; other site 637909000699 prolyl-tRNA synthetase; Provisional; Region: PRK09194 637909000700 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 637909000701 motif 1; other site 637909000702 dimer interface [polypeptide binding]; other site 637909000703 active site 637909000704 motif 2; other site 637909000705 INS is an amino acid-editing domain inserted (INS) into the bacterial class II prolyl-tRNA synthetase (ProRS) however, this CD is not exclusively bacterial. It is also found at the N-terminus of the eukaryotic/archaea-like ProRS's of yeasts and...; Region: ProRS-INS; cd04334 637909000706 putative deacylase active site [active] 637909000707 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 637909000708 active site 637909000709 motif 3; other site 637909000710 ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding; Region: ProRS_anticodon_short; cd00861 637909000711 anticodon binding site; other site 637909000712 DNA polymerase III PolC; Validated; Region: polC; PRK00448 637909000713 DNA polymerase III polC-type N-terminus; Region: DNA_pol3_alph_N; pfam11490 637909000714 polC_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold nucleic acid binding domain of Bacillus subtilis type C replicative DNA polymerase III alpha subunit (polC). Replication in B. subtilis and Staphylococcus aureus requires two...; Region: polC_OBF; cd04484 637909000715 generic binding surface II; other site 637909000716 generic binding surface I; other site 637909000717 Polymerase and Histidinol Phosphatase domain; Region: PHP; cl17102 637909000718 active site 637909000719 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 637909000720 active site 637909000721 catalytic site [active] 637909000722 substrate binding site [chemical binding]; other site 637909000723 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III at PolC gene; Region: PHP_PolIIIA_POLC; cd07435 637909000724 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 637909000725 MarR family; Region: MarR; pfam01047 637909000726 MarR family; Region: MarR_2; cl17246 637909000727 Predicted flavoprotein [General function prediction only]; Region: COG0431 637909000728 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 637909000729 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 637909000730 active site 637909000731 catalytic residues [active] 637909000732 metal binding site [ion binding]; metal-binding site 637909000733 DNA-binding transcriptional activator YeiL; Provisional; Region: PRK10402 637909000734 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 637909000735 ligand binding site [chemical binding]; other site 637909000736 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cl17320 637909000737 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 637909000738 Major Facilitator Superfamily; Region: MFS_1; pfam07690 637909000739 putative substrate translocation pore; other site 637909000740 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 637909000741 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 637909000742 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 637909000743 putative active site [active] 637909000744 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_3; cd07241 637909000745 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 637909000746 putative metal binding site [ion binding]; other site 637909000747 Cof subfamily of IIB subfamily of haloacid dehalogenase superfamily; Region: Cof-subfamily; TIGR00099 637909000748 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 637909000749 active site 637909000750 motif I; other site 637909000751 motif II; other site 637909000752 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 637909000753 Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353 637909000754 16S/18S rRNA binding site [nucleotide binding]; other site 637909000755 S13e-L30e interaction site [polypeptide binding]; other site 637909000756 25S rRNA binding site [nucleotide binding]; other site 637909000757 bifunctional acetaldehyde-CoA/alcohol dehydrogenase; Provisional; Region: PRK13805 637909000758 Coenzyme A acylating aldehyde dehydrogenase (ACDH), ALDH family 20-like; Region: ALDH_F20_ACDH; cd07122 637909000759 putative catalytic cysteine [active] 637909000760 C-terminal alcohol dehydrogenase domain of the acetaldehyde dehydrogenase-alcohol dehydrogenase bifunctional two-domain protein (AAD); Region: AAD_C; cd08178 637909000761 putative active site [active] 637909000762 metal binding site [ion binding]; metal-binding site 637909000763 Predicted membrane protein [Function unknown]; Region: COG2261 637909000764 polynucleotide phosphorylase/polyadenylase; Provisional; Region: PRK11824 637909000765 Polyribonucleotide nucleotidyltransferase, repeat 1; Region: RNase_PH_PNPase_1; cd11363 637909000766 RNase E interface [polypeptide binding]; other site 637909000767 trimer interface [polypeptide binding]; other site 637909000768 Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364 637909000769 RNase E interface [polypeptide binding]; other site 637909000770 trimer interface [polypeptide binding]; other site 637909000771 active site 637909000772 Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393 637909000773 S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472 637909000774 RNA binding site [nucleotide binding]; other site 637909000775 Serine acetyltransferase [Amino acid transport and metabolism]; Region: CysE; COG1045 637909000776 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354 637909000777 trimer interface [polypeptide binding]; other site 637909000778 active site 637909000779 substrate binding site [chemical binding]; other site 637909000780 CoA binding site [chemical binding]; other site 637909000781 cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260 637909000782 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 637909000783 active site 637909000784 HIGH motif; other site 637909000785 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 637909000786 KMSKS motif; other site 637909000787 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 637909000788 tRNA binding surface [nucleotide binding]; other site 637909000789 anticodon binding site; other site 637909000790 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 637909000791 active site 637909000792 metal binding site [ion binding]; metal-binding site 637909000793 dimerization interface [polypeptide binding]; other site 637909000794 rRNA methylase, putative, group 3; Region: rRNA_methyl_3; TIGR00186 637909000795 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032 637909000796 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 637909000797 YacP-like NYN domain; Region: NYN_YacP; cl01491 637909000798 EDD domain protein, DegV family; Region: DegV; TIGR00762 637909000799 Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645 637909000800 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 637909000801 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 637909000802 non-specific DNA binding site [nucleotide binding]; other site 637909000803 salt bridge; other site 637909000804 sequence-specific DNA binding site [nucleotide binding]; other site 637909000805 Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558 637909000806 2-dehydropantoate 2-reductase; Reviewed; Region: PRK06522 637909000807 Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546 637909000808 Ribosomal protein L13. Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392 637909000809 23S rRNA interface [nucleotide binding]; other site 637909000810 L3 interface [polypeptide binding]; other site 637909000811 30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132 637909000812 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 637909000813 ACT domain proteins similar to the yet uncharacterized Streptococcus pneumoniae ACT domain protein; Region: ACT_1ZPV; cd04872 637909000814 Uncharacterized proteins with similarity to Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL_like_DUF711; cd08025 637909000815 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 637909000816 catalytic core [active] 637909000817 D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: VanY; COG1876 637909000818 D-alanyl-D-alanine carboxypeptidase; Region: VanY; pfam02557 637909000819 Mannosyl-glycoprotein endo-beta-N-acetylglucosaminidase; Region: Glucosaminidase; cl17361 637909000820 heat-inducible transcription repressor; Provisional; Region: hrcA; PRK00082 637909000821 GrpE; Region: GrpE; pfam01025 637909000822 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446 637909000823 dimer interface [polypeptide binding]; other site 637909000824 hsp70 (ATPase domain) interactions [polypeptide binding]; other site 637909000825 molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290 637909000826 Nucleotide-binding domain of human HSPA9 and similar proteins; Region: HSPA9-Ssq1-like_NBD; cd10234 637909000827 nucleotide binding site [chemical binding]; other site 637909000828 NEF interaction site [polypeptide binding]; other site 637909000829 SBD interface [polypeptide binding]; other site 637909000830 Putative intracellular protease/amidase [General function prediction only]; Region: ThiJ; COG0693 637909000831 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 637909000832 conserved cys residue [active] 637909000833 chaperone protein DnaJ; Provisional; Region: PRK14276 637909000834 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 637909000835 HSP70 interaction site [polypeptide binding]; other site 637909000836 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cl03262 637909000837 substrate binding site [polypeptide binding]; other site 637909000838 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 637909000839 Zn binding sites [ion binding]; other site 637909000840 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 637909000841 dimer interface [polypeptide binding]; other site 637909000842 tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021 637909000843 Eukaryotic and bacterial pseudouridine synthases similar to E. coli TruA; Region: PseudoU_synth_EcTruA; cd02570 637909000844 dimerization interface 3.5A [polypeptide binding]; other site 637909000845 active site 637909000846 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 637909000847 dimer interface [polypeptide binding]; other site 637909000848 substrate binding site [chemical binding]; other site 637909000849 ATP binding site [chemical binding]; other site 637909000850 ECF-type riboflavin transporter, S component; Region: ECF-ribofla_trS; pfam07155 637909000851 Protein of unknown function (DUF3816); Region: DUF3816; pfam12822 637909000852 hypothetical protein; Provisional; Region: PRK13690 637909000853 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 637909000854 Mechanosensitive ion channel; Region: MS_channel; pfam00924 637909000855 trigger factor; Provisional; Region: tig; PRK01490 637909000856 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 637909000857 Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698 637909000858 DNA-directed RNA polymerase delta subunit; Region: RNA_pol_delta; pfam05066 637909000859 CTP synthetase; Validated; Region: pyrG; PRK05380 637909000860 CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113 637909000861 Catalytic site [active] 637909000862 active site 637909000863 UTP binding site [chemical binding]; other site 637909000864 Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746 637909000865 active site 637909000866 putative oxyanion hole; other site 637909000867 catalytic triad [active] 637909000868 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 637909000869 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 637909000870 fructose-bisphosphate aldolase; Provisional; Region: PRK09197 637909000871 Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947 637909000872 intersubunit interface [polypeptide binding]; other site 637909000873 active site 637909000874 zinc binding site [ion binding]; other site 637909000875 Na+ binding site [ion binding]; other site 637909000876 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315 637909000877 C-5 cytosine-specific DNA methylase; Region: DNA_methylase; pfam00145 637909000878 cofactor binding site; other site 637909000879 DNA binding site [nucleotide binding] 637909000880 substrate interaction site [chemical binding]; other site 637909000881 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315 637909000882 Domain of Unknown Function with PDB structure (DUF3850); Region: DUF3850; pfam12961 637909000883 Replication initiator protein A (RepA) N-terminus; Region: RepA_N; pfam06970 637909000884 putative lipoprotein; Provisional; Region: PRK09707 637909000885 SEC10/PgrA surface exclusion domain; Region: Surf_Exclu_PgrA; TIGR04320 637909000886 LPXTG-motif cell wall anchor domain; Region: LPXTG_anchor; TIGR01167 637909000887 putative cross-wall-targeting lipoprotein signal; Region: strep_RK_lipo; TIGR03726 637909000888 Glucan-binding protein C; Region: GbpC; pfam08363 637909000889 PrgI family protein; Region: PrgI; pfam12666 637909000890 AAA-like domain; Region: AAA_10; pfam12846 637909000891 NQR2, RnfD, RnfE family; Region: NQR2_RnfD_RnfE; cl00779 637909000892 Peptidase family M23; Region: Peptidase_M23; pfam01551 637909000893 CHAP domain; Region: CHAP; pfam05257 637909000894 Replication protein A, class 2b aminoacyl-tRNA synthetases, and related proteins with oligonucleotide/oligosaccharide (OB) fold; Region: RPA_2b-aaRSs_OBF_like; cl09930 637909000895 generic binding surface II; other site 637909000896 Protein of unknown function (DUF3801); Region: DUF3801; pfam12687 637909000897 AAA-like domain; Region: AAA_10; pfam12846 637909000898 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 637909000899 Walker A motif; other site 637909000900 ATP binding site [chemical binding]; other site 637909000901 Walker B motif; other site 637909000902 TOPRIM_TopoIA_TopoIII: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to topoisomerase III. Type IA DNA topoisomerases remove (relax) negative supercoils in the DNA by: cleaving...; Region: TOPRIM_TopoIA_TopoIII; cd03362 637909000903 DNA topoisomerase III; Provisional; Region: PRK07726 637909000904 active site 637909000905 putative interdomain interaction site [polypeptide binding]; other site 637909000906 putative metal-binding site [ion binding]; other site 637909000907 putative nucleotide binding site [chemical binding]; other site 637909000908 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 637909000909 domain I; other site 637909000910 DNA binding groove [nucleotide binding] 637909000911 phosphate binding site [ion binding]; other site 637909000912 domain II; other site 637909000913 domain III; other site 637909000914 nucleotide binding site [chemical binding]; other site 637909000915 catalytic site [active] 637909000916 domain IV; other site 637909000917 Protein of unknown function (DUF3991); Region: DUF3991; pfam13154 637909000918 Toprim-like; Region: Toprim_2; pfam13155 637909000919 Domain of unknown function (DUF955); Region: DUF955; cl01076 637909000920 Relaxase/Mobilisation nuclease domain; Region: Relaxase; pfam03432 637909000921 Sortases are cysteine transpeptidases, found in gram-positive bacteria, that anchor surface proteins to peptidoglycans of the bacterial cell wall envelope. They do so by catalyzing a transpeptidation reaction in which the surface protein substrate is...; Region: Sortase; cl09098 637909000922 active site 637909000923 Uncharacterized protein family (UPF0236); Region: UPF0236; pfam06782 637909000924 50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359 637909000925 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1302 637909000926 DAK2 domain fusion protein YloV; Region: YloV; TIGR03599 637909000927 DAK2 domain; Region: Dak2; pfam02734 637909000928 dihydroxy-acid dehydratase; Provisional; Region: PRK00911 637909000929 6-phosphogluconate dehydratase; Region: edd; TIGR01196 637909000930 acetolactate synthase catalytic subunit; Reviewed; Region: PRK07282 637909000931 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 637909000932 PYR/PP interface [polypeptide binding]; other site 637909000933 dimer interface [polypeptide binding]; other site 637909000934 TPP binding site [chemical binding]; other site 637909000935 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 637909000936 Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015 637909000937 TPP-binding site [chemical binding]; other site 637909000938 dimer interface [polypeptide binding]; other site 637909000939 acetolactate synthase 3 regulatory subunit; Reviewed; Region: ilvH; PRK11895 637909000940 N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878 637909000941 putative valine binding site [chemical binding]; other site 637909000942 dimer interface [polypeptide binding]; other site 637909000943 Small subunit of acetolactate synthase; Region: ALS_ss_C; pfam10369 637909000944 ketol-acid reductoisomerase; Provisional; Region: PRK05479 637909000945 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvN; pfam07991 637909000946 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450 637909000947 threonine dehydratase; Validated; Region: PRK08639 637909000948 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 637909000949 tetramer interface [polypeptide binding]; other site 637909000950 pyridoxal 5'-phosphate binding site [chemical binding]; other site 637909000951 catalytic residue [active] 637909000952 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 637909000953 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 637909000954 A subgroup of the band 7 domain of flotillin (reggie) like proteins. This subgroup contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin. Many of these band 7 domain-containing proteins are lipid raft-associated. Individual...; Region: Band_7_4; cd03407 637909000955 VanZ like family; Region: VanZ; pfam04892 637909000956 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 637909000957 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 637909000958 Walker A/P-loop; other site 637909000959 ATP binding site [chemical binding]; other site 637909000960 Q-loop/lid; other site 637909000961 ABC transporter signature motif; other site 637909000962 Walker B; other site 637909000963 D-loop; other site 637909000964 H-loop/switch region; other site 637909000965 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 637909000966 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 637909000967 substrate binding pocket [chemical binding]; other site 637909000968 membrane-bound complex binding site; other site 637909000969 hinge residues; other site 637909000970 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 637909000971 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 637909000972 dimer interface [polypeptide binding]; other site 637909000973 conserved gate region; other site 637909000974 putative PBP binding loops; other site 637909000975 ABC-ATPase subunit interface; other site 637909000976 Predicted membrane protein (DUF2207); Region: DUF2207; pfam09972 637909000977 undecaprenyl pyrophosphate phosphatase; Reviewed; Region: PRK00281 637909000978 adaptor protein; Provisional; Region: PRK02315 637909000979 UDP-N-acetylmuramyl pentapeptide phosphotransferase/UDP-N- acetylglucosamine-1-phosphate transferase [Cell envelope biogenesis, outer membrane]; Region: Rfe; COG0472 637909000980 This subfamily contains Escherichia coli WecA, Bacillus subtilis TagO and related proteins. WecA is an UDP-N-acetylglucosamine (GlcNAc):undecaprenyl-phosphate (Und-P) GlcNAc-1-phosphate transferase that catalyzes the formation of a phosphodiester bond...; Region: GT_WecA_like; cd06853 637909000981 Mg++ binding site [ion binding]; other site 637909000982 putative catalytic motif [active] 637909000983 substrate binding site [chemical binding]; other site 637909000984 Cysteine desulfurase activator ATPase [Posttranslational modification, protein turnover, chaperones]; Region: sufC; COG0396 637909000985 ABC-type transport system involved in Fe-S cluster assembly, ATPase component; Region: ABC_FeS_Assembly; cd03217 637909000986 Walker A/P-loop; other site 637909000987 ATP binding site [chemical binding]; other site 637909000988 Q-loop/lid; other site 637909000989 ABC transporter signature motif; other site 637909000990 Walker B; other site 637909000991 D-loop; other site 637909000992 H-loop/switch region; other site 637909000993 Cysteine desulfurase activator SufB [Posttranslational modification, protein turnover, chaperones]; Region: SufB; COG0719 637909000994 cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814; cl03223 637909000995 FeS assembly protein SufD; Region: sufD; TIGR01981 637909000996 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 637909000997 Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453 637909000998 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 637909000999 catalytic residue [active] 637909001000 NifU homolog involved in Fe-S cluster formation [Energy production and conversion]; Region: IscU; COG0822 637909001001 Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664 637909001002 trimerization site [polypeptide binding]; other site 637909001003 active site 637909001004 cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814; cl03223 637909001005 FeS assembly protein SufB; Region: sufB; TIGR01980 637909001006 D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: DacC; COG1686 637909001007 Beta-lactamase; Region: Beta-lactamase; cl17358 637909001008 Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; smart00936 637909001009 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 637909001010 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 637909001011 peptide binding site [polypeptide binding]; other site 637909001012 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 637909001013 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 637909001014 dimer interface [polypeptide binding]; other site 637909001015 conserved gate region; other site 637909001016 putative PBP binding loops; other site 637909001017 ABC-ATPase subunit interface; other site 637909001018 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 637909001019 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 637909001020 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 637909001021 dimer interface [polypeptide binding]; other site 637909001022 conserved gate region; other site 637909001023 putative PBP binding loops; other site 637909001024 ABC-ATPase subunit interface; other site 637909001025 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 637909001026 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 637909001027 Walker A/P-loop; other site 637909001028 ATP binding site [chemical binding]; other site 637909001029 Q-loop/lid; other site 637909001030 ABC transporter signature motif; other site 637909001031 Walker B; other site 637909001032 D-loop; other site 637909001033 H-loop/switch region; other site 637909001034 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 637909001035 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 637909001036 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 637909001037 Walker A/P-loop; other site 637909001038 ATP binding site [chemical binding]; other site 637909001039 Q-loop/lid; other site 637909001040 ABC transporter signature motif; other site 637909001041 Walker B; other site 637909001042 D-loop; other site 637909001043 H-loop/switch region; other site 637909001044 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352 637909001045 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 637909001046 Endoglucanase [Carbohydrate transport and metabolism]; Region: BglC; COG2730 637909001047 Cellulase (glycosyl hydrolase family 5); Region: Cellulase; pfam00150 637909001048 aspartate kinase; Reviewed; Region: PRK09034 637909001049 AAK_AKiii-YclM-BS: Amino Acid Kinase Superfamily (AAK), AKiii-YclM-BS; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the lysine plus threonine-sensitive aspartokinase isoenzyme AKIII, a monofunctional class enzyme found in...; Region: AAK_AKiii-YclM-BS; cd04245 637909001050 putative catalytic residues [active] 637909001051 putative nucleotide binding site [chemical binding]; other site 637909001052 putative aspartate binding site [chemical binding]; other site 637909001053 ACT domains located C-terminal to the catalytic domain of the lysine plus threonine-sensitive aspartokinase isoenzyme AKIII; Region: ACT_AKiii-YclM-BS_1; cd04911 637909001054 allosteric regulatory residue; other site 637909001055 ACT domains located C-terminal to the catalytic domain of the lysine plus threonine-sensitive aspartokinase isoenzyme AKIII; Region: ACT_AKiii-YclM-BS_2; cd04916 637909001056 Predicted phosphatase/phosphohexomutase [General function prediction only]; Region: COG0637 637909001057 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 637909001058 motif II; other site 637909001059 enoyl-CoA hydratase; Provisional; Region: PRK07260 637909001060 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 637909001061 substrate binding site [chemical binding]; other site 637909001062 oxyanion hole (OAH) forming residues; other site 637909001063 trimer interface [polypeptide binding]; other site 637909001064 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 637909001065 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 637909001066 putative Zn2+ binding site [ion binding]; other site 637909001067 putative DNA binding site [nucleotide binding]; other site 637909001068 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352 637909001069 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 637909001070 dimer interface [polypeptide binding]; other site 637909001071 active site 637909001072 CoA binding pocket [chemical binding]; other site 637909001073 acyl carrier protein; Provisional; Region: acpP; PRK00982 637909001074 putative enoyl-[acyl-carrier-protein] reductase II; Region: enACPred_II; TIGR03151 637909001075 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 637909001076 FMN binding site [chemical binding]; other site 637909001077 substrate binding site [chemical binding]; other site 637909001078 putative catalytic residue [active] 637909001079 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 637909001080 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 637909001081 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 637909001082 beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333 637909001083 NAD(P) binding site [chemical binding]; other site 637909001084 homotetramer interface [polypeptide binding]; other site 637909001085 homodimer interface [polypeptide binding]; other site 637909001086 active site 637909001087 3-oxoacyl-(acyl carrier protein) synthase II; Reviewed; Region: PRK07314 637909001088 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 637909001089 dimer interface [polypeptide binding]; other site 637909001090 active site 637909001091 acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated; Region: PRK06302 637909001092 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 637909001093 carboxyltransferase (CT) interaction site; other site 637909001094 biotinylation site [posttranslational modification]; other site 637909001095 FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288 637909001096 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591 637909001097 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 637909001098 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 637909001099 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 637909001100 acetyl-CoA carboxylase subunit beta; Validated; Region: PRK05654 637909001101 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 637909001102 acetyl-CoA carboxylase subunit alpha; Provisional; Region: PRK12319 637909001103 seryl-tRNA synthetase; Provisional; Region: PRK05431 637909001104 Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403 637909001105 Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770 637909001106 dimer interface [polypeptide binding]; other site 637909001107 active site 637909001108 motif 1; other site 637909001109 motif 2; other site 637909001110 motif 3; other site 637909001111 Domain of unknown function (DUF956); Region: DUF956; pfam06115 637909001112 Phosphotransferase system, mannose/fructose/N-acetylgalactosamine-specific component IID [Carbohydrate transport and metabolism]; Region: ManZ; COG3716 637909001113 PTS system mannose-specific transporter subunits IIAB; Provisional; Region: PRK15088 637909001114 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006 637909001115 active pocket/dimerization site; other site 637909001116 active site 637909001117 phosphorylation site [posttranslational modification] 637909001118 PTS_IIB, PTS system, Mannose/sorbose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_man; cd00001 637909001119 active site 637909001120 phosphorylation site [posttranslational modification] 637909001121 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 637909001122 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 637909001123 active site 637909001124 motif I; other site 637909001125 motif II; other site 637909001126 Protein of unknown function (DUF1361); Region: DUF1361; pfam07099 637909001127 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 637909001128 Predicted ATPase or kinase [General function prediction only]; Region: COG0802 637909001129 putative acetyltransferase YhhY; Provisional; Region: PRK10140 637909001130 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 637909001131 Coenzyme A binding pocket [chemical binding]; other site 637909001132 Transcriptional regulator [Transcription]; Region: LytR; COG1316 637909001133 HINT (histidine triad nucleotide-binding protein) subgroup: Members of this CD belong to the superfamily of histidine triad hydrolases that act on alpha-phosphate of ribonucleotides. This subgroup includes members from all three forms of cellular life; Region: HINT_subgroup; cd01277 637909001134 HIT family signature motif; other site 637909001135 catalytic residue [active] 637909001136 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 637909001137 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 637909001138 Walker A/P-loop; other site 637909001139 ATP binding site [chemical binding]; other site 637909001140 Q-loop/lid; other site 637909001141 ABC transporter signature motif; other site 637909001142 Walker B; other site 637909001143 D-loop; other site 637909001144 H-loop/switch region; other site 637909001145 Bacterial ABC transporter protein EcsB; Region: EcsB; pfam05975 637909001146 Thiamine kinase and related kinases [Coenzyme transport and metabolism]; Region: ycfN; COG0510 637909001147 Phosphotransferase enzyme family; Region: APH; pfam01636 637909001148 substrate binding site [chemical binding]; other site 637909001149 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 637909001150 S-adenosylmethionine binding site [chemical binding]; other site 637909001151 PAS fold; Region: PAS_4; pfam08448 637909001152 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 637909001153 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 637909001154 metal binding site [ion binding]; metal-binding site 637909001155 active site 637909001156 I-site; other site 637909001157 DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179 637909001158 Ligand binding site; other site 637909001159 Putative Catalytic site; other site 637909001160 DXD motif; other site 637909001161 Predicted membrane protein [Function unknown]; Region: COG2246 637909001162 GtrA-like protein; Region: GtrA; pfam04138 637909001163 Glycosyltransferases, probably involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: COG1215 637909001164 CESA_CelA_like are involved in the elongation of the glucan chain of cellulose; Region: CESA_CelA_like; cd06421 637909001165 DXD motif; other site 637909001166 PilZ domain; Region: PilZ; pfam07238 637909001167 ribosome maturation protein RimP; Reviewed; Region: PRK00092 637909001168 Bacillus subtilis YxlS-like, C-terminal domain; Region: YlxS_C; cd01734 637909001169 putative oligomer interface [polypeptide binding]; other site 637909001170 putative RNA binding site [nucleotide binding]; other site 637909001171 transcription elongation factor NusA; Provisional; Region: nusA; PRK12327 637909001172 NusA N-terminal domain; Region: NusA_N; pfam08529 637909001173 S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455 637909001174 RNA binding site [nucleotide binding]; other site 637909001175 homodimer interface [polypeptide binding]; other site 637909001176 NusA-like KH domain; Region: KH_5; pfam13184 637909001177 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 637909001178 G-X-X-G motif; other site 637909001179 Ylxr homologs; group of conserved hypothetical bacterial proteins of unknown function; structure revealed putative RNA binding cleft; proteins are encoded by an operon that includes other proteins involved in transcription and/or translation; Region: YlxR; cd00279 637909001180 putative RNA binding cleft [nucleotide binding]; other site 637909001181 hypothetical protein; Provisional; Region: PRK07283 637909001182 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 637909001183 translation initiation factor IF-2; Region: IF-2; TIGR00487 637909001184 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 637909001185 Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887 637909001186 G1 box; other site 637909001187 putative GEF interaction site [polypeptide binding]; other site 637909001188 GTP/Mg2+ binding site [chemical binding]; other site 637909001189 Switch I region; other site 637909001190 G2 box; other site 637909001191 G3 box; other site 637909001192 Switch II region; other site 637909001193 G4 box; other site 637909001194 G5 box; other site 637909001195 This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702 637909001196 Translation-initiation factor 2; Region: IF-2; pfam11987 637909001197 mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692 637909001198 ribosome-binding factor A; Validated; Region: rbfA; PRK00521 637909001199 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 637909001200 Helix-turn-helix domain; Region: HTH_38; pfam13936 637909001201 putative transposase OrfB; Reviewed; Region: PHA02517 637909001202 HTH-like domain; Region: HTH_21; pfam13276 637909001203 Integrase core domain; Region: rve; pfam00665 637909001204 Integrase core domain; Region: rve_2; pfam13333 637909001205 Predicted Rossmann fold nucleotide-binding protein [General function prediction only]; Region: COG1611 637909001206 Bacterial protein of unknown function (DUF925); Region: DUF925; pfam06042 637909001207 copper transport repressor, CopY/TcrY family; Region: CopY_TcrY; TIGR02698 637909001208 Penicillinase repressor; Region: Pencillinase_R; pfam03965 637909001209 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 637909001210 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 637909001211 metal-binding site [ion binding] 637909001212 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 637909001213 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 637909001214 motif II; other site 637909001215 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 637909001216 metal-binding site [ion binding] 637909001217 Predicted membrane protein [Function unknown]; Region: COG2860 637909001218 UPF0126 domain; Region: UPF0126; pfam03458 637909001219 UPF0126 domain; Region: UPF0126; pfam03458 637909001220 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 637909001221 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 637909001222 active site 637909001223 motif I; other site 637909001224 motif II; other site 637909001225 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 637909001226 Protein of unknown function (DUF2974); Region: DUF2974; pfam11187 637909001227 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 637909001228 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 637909001229 Uncharacterized protein conserved in bacteria [Function unknown]; Region: DegV; COG1307 637909001230 Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645 637909001231 Bacterial inner membrane protein; Region: Imp-YgjV; pfam10688 637909001232 Na+/phosphate symporter [Inorganic ion transport and metabolism]; Region: NptA; COG1283 637909001233 Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690 637909001234 Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690 637909001235 PhoU domain; Region: PhoU; pfam01895 637909001236 N-acetylglucosamine-6-phosphate deacetylase [Carbohydrate transport and metabolism]; Region: NagA; COG1820 637909001237 N-acetylglucosamine-6-phosphate deacetylase, NagA, catalyzes the hydrolysis of the N-acetyl group of N-acetyl-glucosamine-6-phosphate (GlcNAc-6-P) to glucosamine 6-phosphate and acetate. This is the first committed step in the biosynthetic pathway to...; Region: NagA; cd00854 637909001238 active site 637909001239 dimer interface [polypeptide binding]; other site 637909001240 Class II Glycyl-tRNA synthetase (GlyRS) alpha subunit core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes and in arabidopsis. It is responsible for the...; Region: GlyRS_alpha_core; cd00733 637909001241 dimer interface [polypeptide binding]; other site 637909001242 motif 1; other site 637909001243 active site 637909001244 motif 2; other site 637909001245 motif 3; other site 637909001246 glycyl-tRNA synthetase subunit beta; Validated; Region: glyS; PRK01233 637909001247 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 637909001248 hypothetical protein; Provisional; Region: PRK02539 637909001249 HTH domain; Region: HTH_11; pfam08279 637909001250 Transcriptional antiterminator [Transcription]; Region: BglG; COG3711 637909001251 Mga helix-turn-helix domain; Region: Mga; pfam05043 637909001252 PRD domain; Region: PRD; pfam00874 637909001253 PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568 637909001254 active site 637909001255 P-loop; other site 637909001256 phosphorylation site [posttranslational modification] 637909001257 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cl00163 637909001258 active site 637909001259 phosphorylation site [posttranslational modification] 637909001260 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 637909001261 active site 637909001262 phosphorylation site [posttranslational modification] 637909001263 PTS_IIB_ascorbate: subunit IIB of enzyme II (EII) of the L-ascorbate-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is an L-ascorbate-specific permease with two cytoplasmic subunits (IIA and IIB) and a...; Region: PTS_IIB_ascorbate; cd05563 637909001264 active site 637909001265 P-loop; other site 637909001266 phosphorylation site [posttranslational modification] 637909001267 PTS system ascorbate-specific transporter subunit IIC; Reviewed; Region: ulaA; PRK09410 637909001268 Transaldolase-like fructose-6-phosphate aldolases (FSA) found in bacteria and archaea; Region: Transaldolase_FSA; cd00956 637909001269 active site 637909001270 intersubunit interactions; other site 637909001271 catalytic residue [active] 637909001272 Transketolase [Carbohydrate transport and metabolism]; Region: TktA; COG0021 637909001273 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 637909001274 TPP-binding site [chemical binding]; other site 637909001275 dimer interface [polypeptide binding]; other site 637909001276 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 637909001277 PYR/PP interface [polypeptide binding]; other site 637909001278 dimer interface [polypeptide binding]; other site 637909001279 TPP binding site [chemical binding]; other site 637909001280 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 637909001281 Enterocin A Immunity; Region: EntA_Immun; pfam08951 637909001282 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 637909001283 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 637909001284 Walker A/P-loop; other site 637909001285 ATP binding site [chemical binding]; other site 637909001286 Q-loop/lid; other site 637909001287 ABC transporter signature motif; other site 637909001288 Walker B; other site 637909001289 D-loop; other site 637909001290 H-loop/switch region; other site 637909001291 PTS system, beta-glucoside-specific IIABC component; Region: PTS-II-ABC-beta; TIGR01995 637909001292 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 637909001293 active site turn [active] 637909001294 phosphorylation site [posttranslational modification] 637909001295 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 637909001296 Phosphotransferase system IIA components [Carbohydrate transport and metabolism]; Region: NagE; COG2190 637909001297 HPr interaction site; other site 637909001298 glycerol kinase (GK) interaction site [polypeptide binding]; other site 637909001299 active site 637909001300 phosphorylation site [posttranslational modification] 637909001301 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 637909001302 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 637909001303 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 637909001304 putative active site [active] 637909001305 Glycosyl hydrolase family 1; Region: Glyco_hydro_1; cl01046 637909001306 beta-galactosidase; Region: BGL; TIGR03356 637909001307 Glutamate 5-kinase [Amino acid transport and metabolism]; Region: ProB; COG0263 637909001308 AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242 637909001309 nucleotide binding site [chemical binding]; other site 637909001310 homotetrameric interface [polypeptide binding]; other site 637909001311 putative phosphate binding site [ion binding]; other site 637909001312 putative allosteric binding site; other site 637909001313 Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079 637909001314 gamma-glutamyl phosphate reductase; Region: proA; TIGR00407 637909001315 putative catalytic cysteine [active] 637909001316 Predicted S-adenosylmethionine-dependent methyltransferase involved in cell envelope biogenesis [Cell envelope biogenesis, outer membrane]; Region: COG0275 637909001317 MraW methylase family; Region: Methyltransf_5; pfam01795 637909001318 Protein required for the initiation of cell division [Cell division and chromosome partitioning]; Region: FtsL; COG4839 637909001319 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 637909001320 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 637909001321 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 637909001322 PASTA domain of PBP2x-like proteins, first repeat. Penicillin-binding proteins (PBPs) are the major targets for beta-lactam antibiotics, like penicillins and cephalosporins. Beta-lactam antibiotics specifically inhibit transpeptidase activity by...; Region: PASTA_Pbp2x-like_1; cd06576 637909001323 PASTA domain of PBP2x-like proteins, second repeat. Penicillin-binding proteins (PBPs) are the major targets for beta-lactam antibiotics, like penicillins and cephalosporins. Beta-lactam antibiotics specifically inhibit transpeptidase activity by...; Region: PASTA_Pbp2x-like_2; cd06575 637909001324 phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108 637909001325 Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852 637909001326 Mg++ binding site [ion binding]; other site 637909001327 putative catalytic motif [active] 637909001328 putative substrate binding site [chemical binding]; other site 637909001329 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 637909001330 DEAD-like helicases superfamily; Region: DEXDc; smart00487 637909001331 ATP binding site [chemical binding]; other site 637909001332 Mg++ binding site [ion binding]; other site 637909001333 motif III; other site 637909001334 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 637909001335 nucleotide binding region [chemical binding]; other site 637909001336 ATP-binding site [chemical binding]; other site 637909001337 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 637909001338 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 637909001339 substrate binding pocket [chemical binding]; other site 637909001340 membrane-bound complex binding site; other site 637909001341 hinge residues; other site 637909001342 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 637909001343 dimer interface [polypeptide binding]; other site 637909001344 conserved gate region; other site 637909001345 putative PBP binding loops; other site 637909001346 ABC-ATPase subunit interface; other site 637909001347 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 637909001348 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 637909001349 Walker A/P-loop; other site 637909001350 ATP binding site [chemical binding]; other site 637909001351 Q-loop/lid; other site 637909001352 ABC transporter signature motif; other site 637909001353 Walker B; other site 637909001354 D-loop; other site 637909001355 H-loop/switch region; other site 637909001356 Protein of unknown function (DUF4059); Region: DUF4059; pfam13268 637909001357 thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292 637909001358 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 637909001359 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 637909001360 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 637909001361 active site 637909001362 catalytic residues [active] 637909001363 DNA binding site [nucleotide binding] 637909001364 Int/Topo IB signature motif; other site 637909001365 Abi-like protein; Region: Abi_2; pfam07751 637909001366 Domain of unknown function (DUF955); Region: DUF955; pfam06114 637909001367 PGDYG protein; Region: PGDYG; pfam14083 637909001368 MTH538 TIR-like domain (DUF1863); Region: DUF1863; pfam08937 637909001369 Protein of unknown function (DUF4231); Region: DUF4231; pfam14015 637909001370 Domain of unknown function (DUF955); Region: DUF955; cl01076 637909001371 Double zinc ribbon; Region: DZR; pfam12773 637909001372 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 637909001373 non-specific DNA binding site [nucleotide binding]; other site 637909001374 salt bridge; other site 637909001375 sequence-specific DNA binding site [nucleotide binding]; other site 637909001376 Protein of unknown function (DUF739); Region: DUF739; pfam05339 637909001377 Prophage antirepressor [Transcription]; Region: COG3617 637909001378 BRO family, N-terminal domain; Region: Bro-N; smart01040 637909001379 Phage antirepressor protein KilAC domain; Region: ANT; pfam03374 637909001380 Helix-turn-helix domain; Region: HTH_17; cl17695 637909001381 AAA domain; Region: AAA_23; pfam13476 637909001382 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 637909001383 Walker A/P-loop; other site 637909001384 ATP binding site [chemical binding]; other site 637909001385 Q-loop/lid; other site 637909001386 chloroplast Hsp70; Provisional; Region: PLN03184 637909001387 AAA domain; Region: AAA_24; pfam13479 637909001388 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 637909001389 Walker A motif; other site 637909001390 ATP binding site [chemical binding]; other site 637909001391 DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061 637909001392 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 637909001393 ATP binding site [chemical binding]; other site 637909001394 putative Mg++ binding site [ion binding]; other site 637909001395 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 637909001396 nucleotide binding region [chemical binding]; other site 637909001397 ATP-binding site [chemical binding]; other site 637909001398 Primase C terminal 2 (PriCT-2); Region: PriCT_2; pfam08707 637909001399 RecA-family ATPase [DNA replication, recombination, and repair]; Region: RepA; COG3598 637909001400 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 637909001401 Walker A motif; other site 637909001402 ATP binding site [chemical binding]; other site 637909001403 Walker B motif; other site 637909001404 Holliday junction resolvase [DNA replication, recombination, and repair]; Region: Rus; COG4570 637909001405 phage transcriptional activator, RinA family; Region: phage_rinA; TIGR01636 637909001406 Terminase-like family; Region: Terminase_6; pfam03237 637909001407 Phage terminase large subunit; Region: Terminase_3; cl12054 637909001408 phage portal protein, SPP1 family; Region: portal_SPP1; TIGR01538 637909001409 Phage portal protein, SPP1 Gp6-like; Region: Phage_prot_Gp6; pfam05133 637909001410 Phage Mu protein F like protein; Region: Phage_Mu_F; cl10072 637909001411 Domain of unknown function (DUF4355); Region: DUF4355; pfam14265 637909001412 Phage major capsid protein E; Region: Phage_cap_E; pfam03864 637909001413 Phage gp6-like head-tail connector protein; Region: Phage_connect_1; pfam05135 637909001414 Bacteriophage protein of unknown function (DUF646); Region: DUF646; pfam04883 637909001415 Phage major tail protein 2; Region: Phage_tail_2; cl11463 637909001416 Phage protein; Region: DUF3647; cl10335 637909001417 phage tail tape measure protein, TP901 family, core region; Region: tape_meas_TP901; TIGR01760 637909001418 Phage tail protein; Region: Sipho_tail; cl17486 637909001419 Prophage endopeptidase tail; Region: Prophage_tail; pfam06605 637909001420 SH3 domain protein; Region: SH3_and_anchor; TIGR04211 637909001421 Phage lysis protein, holin; Region: Phage_holin; cl04675 637909001422 CHAP domain; Region: CHAP; cl17642 637909001423 Spindle and kinetochore-associated protein 2; Region: SKA2; cd12955 637909001424 SKA1 interface [polypeptide binding]; other site 637909001425 Bacterial SH3 domain; Region: SH3_3; cl17532 637909001426 Protein of unknown function (DUF4065); Region: DUF4065; cl01445 637909001427 MarC family integral membrane protein; Region: MarC; pfam01914 637909001428 nicotinate phosphoribosyltransferase; Validated; Region: PRK09243 637909001429 Nicotinate phosphoribosyltransferase (NAPRTase), subgroup A. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting, reaction...; Region: NAPRTase_A; cd01570 637909001430 active site 637909001431 NAD synthase [Coenzyme metabolism]; Region: NadE; COG0171 637909001432 NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553 637909001433 homodimer interface [polypeptide binding]; other site 637909001434 NAD binding pocket [chemical binding]; other site 637909001435 ATP binding pocket [chemical binding]; other site 637909001436 Mg binding site [ion binding]; other site 637909001437 active-site loop [active] 637909001438 Peptidase C1B subfamily (MEROPS database nomenclature); composed of eukaryotic bleomycin hydrolases (BH) and bacterial aminopeptidases C (pepC). The proteins of this subfamily contain a large insert relative to the C1A peptidase (papain) subfamily. BH is...; Region: Peptidase_C1B; cd00585 637909001439 trimer interface [polypeptide binding]; other site 637909001440 active site 637909001441 G bulge; other site 637909001442 Transglycosylase; Region: Transgly; pfam00912 637909001443 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 637909001444 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 637909001445 Holliday junction-specific endonuclease; Reviewed; Region: recU; PRK02234 637909001446 hypothetical protein; Provisional; Region: PRK13660 637909001447 cell division protein GpsB; Provisional; Region: PRK14127 637909001448 DivIVA domain; Region: DivI1A_domain; TIGR03544 637909001449 Predicted N6-adenine-specific DNA methylase [DNA replication, recombination, and repair]; Region: COG0116 637909001450 THUMP domain associated with S-adenosylmethionine-dependent methyltransferases; Region: THUMP_AdoMetMT; cd11715 637909001451 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 637909001452 acetoin reductase; Validated; Region: PRK08643 637909001453 meso-2,3-butanediol dehydrogenase-like, classical (c) SDRs; Region: meso-BDH-like_SDR_c; cd05366 637909001454 NAD binding site [chemical binding]; other site 637909001455 homotetramer interface [polypeptide binding]; other site 637909001456 homodimer interface [polypeptide binding]; other site 637909001457 active site 637909001458 substrate binding site [chemical binding]; other site 637909001459 S-ribosylhomocysteinase; Provisional; Region: PRK02260 637909001460 hypothetical protein; Provisional; Region: PRK00106 637909001461 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 637909001462 Zn2+ binding site [ion binding]; other site 637909001463 Mg2+ binding site [ion binding]; other site 637909001464 Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194 637909001465 Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071 637909001466 catalytic site [active] 637909001467 G-X2-G-X-G-K; other site 637909001468 DNA-directed RNA polymerase subunit omega; Reviewed; Region: rpoZ; PRK00392 637909001469 Primosomal protein N' (replication factor Y) - superfamily II helicase [DNA replication, recombination, and repair]; Region: PriA; COG1198 637909001470 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 637909001471 ATP binding site [chemical binding]; other site 637909001472 putative Mg++ binding site [ion binding]; other site 637909001473 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 637909001474 ATP-binding site [chemical binding]; other site 637909001475 methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005 637909001476 Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646 637909001477 putative active site [active] 637909001478 substrate binding site [chemical binding]; other site 637909001479 putative cosubstrate binding site; other site 637909001480 catalytic site [active] 637909001481 C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704 637909001482 substrate binding site [chemical binding]; other site 637909001483 16S rRNA methyltransferase B; Provisional; Region: PRK14902 637909001484 NusB family; Region: NusB; pfam01029 637909001485 putative RNA binding site [nucleotide binding]; other site 637909001486 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 637909001487 S-adenosylmethionine binding site [chemical binding]; other site 637909001488 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143 637909001489 active site 637909001490 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 637909001491 Catalytic domain of Protein Kinases; Region: PKc; cd00180 637909001492 active site 637909001493 ATP binding site [chemical binding]; other site 637909001494 substrate binding site [chemical binding]; other site 637909001495 activation loop (A-loop); other site 637909001496 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 637909001497 PASTA domain. This domain is found at the C-termini of several Penicillin-binding proteins (PBPs) and bacterial serine/threonine kinases. It is a small globular fold consisting of 3 beta-sheets and an alpha-helix. The name PASTA is derived from PBP and...; Region: PASTA; cl02768 637909001498 PASTA domain. This domain is found at the C-termini of several Penicillin-binding proteins (PBPs) and bacterial serine/threonine kinases. It is a small globular fold consisting of 3 beta-sheets and an alpha-helix. The name PASTA is derived from PBP and...; Region: PASTA; cl02768 637909001499 Predicted membrane protein [Function unknown]; Region: COG4758 637909001500 Cell wall-active antibiotics response protein (DUF2154); Region: DUF2154; pfam09922 637909001501 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 637909001502 Histidine kinase; Region: HisKA_3; pfam07730 637909001503 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 637909001504 ATP binding site [chemical binding]; other site 637909001505 Mg2+ binding site [ion binding]; other site 637909001506 G-X-G motif; other site 637909001507 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 637909001508 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 637909001509 active site 637909001510 phosphorylation site [posttranslational modification] 637909001511 intermolecular recognition site; other site 637909001512 dimerization interface [polypeptide binding]; other site 637909001513 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 637909001514 DNA binding residues [nucleotide binding] 637909001515 dimerization interface [polypeptide binding]; other site 637909001516 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 637909001517 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 637909001518 active site 637909001519 motif I; other site 637909001520 motif II; other site 637909001521 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cl17915 637909001522 active site 637909001523 motif I; other site 637909001524 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 637909001525 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317 637909001526 active site 637909001527 Predicted RNA binding protein (contains ribosomal protein S1 domain) [Translation, ribosomal structure and biogenesis]; Region: VacB; COG1098 637909001528 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cd00164 637909001529 RNA binding site [nucleotide binding]; other site 637909001530 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 637909001531 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 637909001532 dimer interface [polypeptide binding]; other site 637909001533 pyridoxal 5'-phosphate binding site [chemical binding]; other site 637909001534 catalytic residue [active] 637909001535 Uncharacterized conserved protein [Function unknown]; Region: COG1739 637909001536 Uncharacterized protein family UPF0029; Region: UPF0029; pfam01205 637909001537 Domain of unknown function (DUF1949); Region: DUF1949; pfam09186 637909001538 Superfamily II DNA/RNA helicase required for DNA uptake (late competence protein) [DNA replication, recombination, and repair]; Region: comFA; COG4098 637909001539 DEAD/DEAH box helicase; Region: DEAD; pfam00270 637909001540 ATP binding site [chemical binding]; other site 637909001541 putative Mg++ binding site [ion binding]; other site 637909001542 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 637909001543 nucleotide binding region [chemical binding]; other site 637909001544 ATP-binding site [chemical binding]; other site 637909001545 Predicted amidophosphoribosyltransferases [General function prediction only]; Region: ComFC; COG1040 637909001546 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 637909001547 active site 637909001548 RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552 637909001549 30S subunit binding site; other site 637909001550 Staphylococcal protein of unknown function (DUF960); Region: DUF960; pfam06124 637909001551 hypothetical protein; Provisional; Region: PRK13662 637909001552 recombination regulator RecX; Provisional; Region: recX; PRK14135 637909001553 TRAM domain; Region: TRAM; pfam01938 637909001554 SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase [Translation, ribosomal structure and biogenesis]; Region: TrmA; COG2265 637909001555 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 637909001556 S-adenosylmethionine binding site [chemical binding]; other site 637909001557 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 637909001558 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 637909001559 putative transposase OrfB; Reviewed; Region: PHA02517 637909001560 HTH-like domain; Region: HTH_21; pfam13276 637909001561 Integrase core domain; Region: rve; pfam00665 637909001562 Integrase core domain; Region: rve_2; pfam13333 637909001563 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 637909001564 Helix-turn-helix domain; Region: HTH_38; pfam13936 637909001565 Predicted peptidase [General function prediction only]; Region: COG4099 637909001566 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 637909001567 Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247 637909001568 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 637909001569 Coenzyme A binding pocket [chemical binding]; other site 637909001570 Nicotinamide mononucleotide transporter; Region: NMN_transporter; cl01256 637909001571 Deoxynucleoside kinases [Nucleotide transport and metabolism]; Region: COG1428 637909001572 Deoxyribonucleoside kinase (dNK) catalyzes the phosphorylation of deoxyribonucleosides to yield corresponding monophosphates (dNMPs). This family consists of various deoxynucleoside kinases including deoxyribo- cytidine (EC 2.7.1.74), guanosine (EC 2.7.1; Region: dNK; cd01673 637909001573 Substrate-binding site [chemical binding]; other site 637909001574 Substrate specificity [chemical binding]; other site 637909001575 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 637909001576 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 637909001577 Coenzyme A binding pocket [chemical binding]; other site 637909001578 Phospholipid methyltransferase; Region: PEMT; pfam04191 637909001579 Domain of unknown function (DUF1912); Region: DUF1912; pfam08930 637909001580 hypothetical protein; Provisional; Region: PRK07758 637909001581 Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family [General function prediction only]; Region: COG1853 637909001582 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 637909001583 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 637909001584 AAA domain; Region: AAA_18; pfam13238 637909001585 Sulphate Transporter and Anti-Sigma factor antagonist domain found in the C-terminal region of sulphate transporters as well as in bacterial and archaeal proteins involved in the regulation of sigma factors; Region: STAS; cl00604 637909001586 valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729 637909001587 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 637909001588 active site 637909001589 HIGH motif; other site 637909001590 nucleotide binding site [chemical binding]; other site 637909001591 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 637909001592 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 637909001593 active site 637909001594 KMSKS motif; other site 637909001595 Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962 637909001596 tRNA binding surface [nucleotide binding]; other site 637909001597 anticodon binding site; other site 637909001598 Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458 637909001599 Nuclease-related domain; Region: NERD; pfam08378 637909001600 Protein of unknown function (DUF419); Region: DUF419; cl15265 637909001601 H+ Antiporter protein; Region: 2A0121; TIGR00900 637909001602 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 637909001603 putative substrate translocation pore; other site 637909001604 probable dihydroxyacetone kinase regulator; Region: DHAK_reg; TIGR02366 637909001605 Transcriptional regulator C-terminal region; Region: TetR_C_8; pfam14278 637909001606 Asparagine synthetase A [Amino acid transport and metabolism]; Region: AsnA; COG2502 637909001607 motif 1; other site 637909001608 dimer interface [polypeptide binding]; other site 637909001609 active site 637909001610 motif 2; other site 637909001611 motif 3; other site 637909001612 V-type ATP synthase subunit I; Validated; Region: PRK05771 637909001613 N6-adenine-specific methylase [DNA replication, recombination, and repair]; Region: COG0742 637909001614 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 637909001615 S-adenosylmethionine binding site [chemical binding]; other site 637909001616 phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168 637909001617 Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163 637909001618 active site 637909001619 (T/H)XGH motif; other site 637909001620 Predicted secreted protein containing a PDZ domain [Signal transduction mechanisms]; Region: SdrC; COG3480 637909001621 PDZ domain, also called DHR (Dlg homologous region) or GLGF (after a conserved sequence motif). Many PDZ domains bind C-terminal polypeptides, though binding to internal (non-C-terminal) polypeptides and even to lipids has been demonstrated; Region: PDZ; cl00117 637909001622 protein binding site [polypeptide binding]; other site 637909001623 Protein of unknown function (DUF3923); Region: DUF3923; pfam13061 637909001624 Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cl00200 637909001625 amphipathic channel; other site 637909001626 Asn-Pro-Ala signature motifs; other site 637909001627 Escherichia coli UshA-like family, N-terminal metallophosphatase domain; Region: MPP_UshA_N_like; cd00845 637909001628 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 637909001629 active site 637909001630 metal binding site [ion binding]; metal-binding site 637909001631 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 637909001632 Protein of unknown function (DUF1027); Region: DUF1027; cl09961 637909001633 ribosomal RNA large subunit methyltransferase N; Provisional; Region: PRK14455 637909001634 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 637909001635 FeS/SAM binding site; other site 637909001636 VanZ like family; Region: VanZ; pfam04892 637909001637 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 637909001638 putative multidrug transporter membrane\ATP-binding components; Provisional; Region: PRK10789 637909001639 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 637909001640 Walker A/P-loop; other site 637909001641 ATP binding site [chemical binding]; other site 637909001642 Q-loop/lid; other site 637909001643 ABC transporter signature motif; other site 637909001644 Walker B; other site 637909001645 D-loop; other site 637909001646 H-loop/switch region; other site 637909001647 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 637909001648 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 637909001649 ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254 637909001650 Walker A/P-loop; other site 637909001651 ATP binding site [chemical binding]; other site 637909001652 Q-loop/lid; other site 637909001653 ABC transporter signature motif; other site 637909001654 Walker B; other site 637909001655 D-loop; other site 637909001656 H-loop/switch region; other site 637909001657 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 637909001658 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 637909001659 Walker A/P-loop; other site 637909001660 ATP binding site [chemical binding]; other site 637909001661 Q-loop/lid; other site 637909001662 ABC transporter signature motif; other site 637909001663 Walker B; other site 637909001664 D-loop; other site 637909001665 H-loop/switch region; other site 637909001666 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 637909001667 Histidine kinase; Region: HisKA_3; pfam07730 637909001668 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 637909001669 ATP binding site [chemical binding]; other site 637909001670 Mg2+ binding site [ion binding]; other site 637909001671 G-X-G motif; other site 637909001672 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 637909001673 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 637909001674 active site 637909001675 phosphorylation site [posttranslational modification] 637909001676 intermolecular recognition site; other site 637909001677 dimerization interface [polypeptide binding]; other site 637909001678 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 637909001679 DNA binding residues [nucleotide binding] 637909001680 dimerization interface [polypeptide binding]; other site 637909001681 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4842 637909001682 WXG100 protein secretion system (Wss), protein EssA; Region: EssA; cl11266 637909001683 WXG100 protein secretion system (Wss), protein YukC; Region: YukC; cl01868 637909001684 type VII secretion protein EssC, C-terminal domain; Region: T7_EssCb_Firm; TIGR03928 637909001685 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 637909001686 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 637909001687 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061 637909001688 V-type ATP synthase subunit I; Validated; Region: PRK05771 637909001689 LXG domain of WXG superfamily; Region: LXG; pfam04740 637909001690 CAAX protease self-immunity; Region: Abi; pfam02517 637909001691 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 637909001692 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 637909001693 Transcriptional regulator C-terminal region; Region: TetR_C_8; pfam14278 637909001694 Cna protein B-type domain; Region: Cna_B; pfam05738 637909001695 Repeat unit of collagen-binding protein domain B; Region: CollagenBindB; cd00222 637909001696 domain interaction interfaces [polypeptide binding]; other site 637909001697 Repeat unit of collagen-binding protein domain B; Region: CollagenBindB; cd00222 637909001698 domain interaction interfaces [polypeptide binding]; other site 637909001699 Repeat unit of collagen-binding protein domain B; Region: CollagenBindB; cd00222 637909001700 domain interaction interfaces [polypeptide binding]; other site 637909001701 Protein of unknown function (DUF2089); Region: DUF2089; pfam09862 637909001702 TraX protein; Region: TraX; cl05434 637909001703 Predicted membrane protein [Function unknown]; Region: COG3371 637909001704 Chorismate mutase type II; Region: CM_2; smart00830 637909001705 anthranilate synthase component I; Provisional; Region: PRK13570 637909001706 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 637909001707 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 637909001708 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 637909001709 Glutamine amidotransferase class-I; Region: GATase; pfam00117 637909001710 glutamine binding [chemical binding]; other site 637909001711 catalytic triad [active] 637909001712 anthranilate phosphoribosyltransferase; Provisional; Region: trpD; PRK00188 637909001713 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 637909001714 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 637909001715 Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331 637909001716 active site 637909001717 ribulose/triose binding site [chemical binding]; other site 637909001718 phosphate binding site [ion binding]; other site 637909001719 substrate (anthranilate) binding pocket [chemical binding]; other site 637909001720 product (indole) binding pocket [chemical binding]; other site 637909001721 Phosphoribosylanthranilate isomerase (PRAI) catalyzes the fourth step of the tryptophan biosynthesis, the conversion of N-(5'- phosphoribosyl)-anthranilate (PRA) to 1-(o-carboxyphenylamino)- 1-deoxyribulose 5-phosphate (CdRP). Most PRAIs are...; Region: PRAI; cd00405 637909001722 active site 637909001723 tryptophan synthase, beta subunit; Region: trpB; TIGR00263 637909001724 Tryptophan synthase-beta: Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446 637909001725 pyridoxal 5'-phosphate binding site [chemical binding]; other site 637909001726 catalytic residue [active] 637909001727 Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724 637909001728 tryptophan synthase alpha subunit; Provisional; Region: trpA; CHL00200 637909001729 substrate binding site [chemical binding]; other site 637909001730 active site 637909001731 catalytic residues [active] 637909001732 heterodimer interface [polypeptide binding]; other site 637909001733 manganese transport protein MntH; Reviewed; Region: PRK00701 637909001734 Natural resistance-associated macrophage protein; Region: Nramp; pfam01566 637909001735 Type II secretory pathway, prepilin signal peptidase PulO and related peptidases [Cell motility and secretion / Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: PulO; COG1989 637909001736 Bacterial Peptidase A24 N-terminal domain; Region: DiS_P_DiS; pfam06750 637909001737 DNA-binding ferritin-like protein (oxidative damage protectant) [Inorganic ion transport and metabolism]; Region: Dps; COG0783 637909001738 DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043 637909001739 dimerization interface [polypeptide binding]; other site 637909001740 DPS ferroxidase diiron center [ion binding]; other site 637909001741 ion pore; other site 637909001742 Bacterial protein of unknown function (DUF910); Region: DUF910; pfam06014 637909001743 ROK family protein (putative glucokinase); Region: ROK_glcA_fam; TIGR00744 637909001744 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 637909001745 nucleotide binding site [chemical binding]; other site 637909001746 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 637909001747 active site residue [active] 637909001748 Predicted membrane GTPase involved in stress response [Signal transduction mechanisms]; Region: TypA; COG1217 637909001749 Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891 637909001750 G1 box; other site 637909001751 putative GEF interaction site [polypeptide binding]; other site 637909001752 GTP/Mg2+ binding site [chemical binding]; other site 637909001753 Switch I region; other site 637909001754 G2 box; other site 637909001755 G3 box; other site 637909001756 Switch II region; other site 637909001757 G4 box; other site 637909001758 G5 box; other site 637909001759 BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu. BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691 637909001760 BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants. BipA is a highly...; Region: BipA_TypA_C; cd03710 637909001761 Protein of unknown function (DUF3165); Region: DUF3165; pfam11364 637909001762 UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK02472 637909001763 Alanine dehydrogenase/PNT, C-terminal domain; Region: AlaDh_PNT_C; smart01002 637909001764 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 637909001765 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 637909001766 undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726 637909001767 MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785 637909001768 homodimer interface [polypeptide binding]; other site 637909001769 active site 637909001770 POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478 637909001771 Cell division protein FtsQ; Region: FtsQ; pfam03799 637909001772 Cell division ATPase FtsA [Cell division and chromosome partitioning]; Region: ftsA; COG0849 637909001773 Cell division protein FtsA; Region: FtsA; smart00842 637909001774 Cell division protein FtsA; Region: FtsA; pfam14450 637909001775 Domain of unknown function (DUF3484); Region: DUF3484; pfam11983 637909001776 cell division protein FtsZ; Validated; Region: PRK09330 637909001777 FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes. FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201 637909001778 nucleotide binding site [chemical binding]; other site 637909001779 SulA interaction site; other site 637909001780 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, YBL036c-like proteins; Region: PLPDE_III_YBL036c_like; cd00635 637909001781 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 637909001782 catalytic residue [active] 637909001783 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1799 637909001784 YGGT family; Region: YGGT; pfam02325 637909001785 Uncharacterized conserved protein, contains S4-like domain [Function unknown]; Region: COG2302 637909001786 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 637909001787 RNA binding surface [nucleotide binding]; other site 637909001788 DivIVA protein; Region: DivIVA; pfam05103 637909001789 DivIVA domain; Region: DivI1A_domain; TIGR03544 637909001790 isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK05743 637909001791 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 637909001792 active site 637909001793 HIGH motif; other site 637909001794 nucleotide binding site [chemical binding]; other site 637909001795 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 637909001796 active site 637909001797 KMSKS motif; other site 637909001798 Anticodon-binding domain of bacterial and eukaryotic mitochondrial isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_BEm; cd07960 637909001799 tRNA binding surface [nucleotide binding]; other site 637909001800 anticodon binding site; other site 637909001801 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 637909001802 Domain of unknown function (DUF1827); Region: DUF1827; pfam08860 637909001803 Contains a crystal structure of the Nudix hydrolase from Enterococcus faecalis, which has an unknown function. In general, members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes...; Region: Nudix_Hydrolase_25; cd04684 637909001804 nudix motif; other site 637909001805 ATP-binding subunits of Clp protease and DnaK/DnaJ chaperones [Posttranslational modification, protein turnover, chaperones]; Region: clpA; COG0542 637909001806 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 637909001807 Walker A motif; other site 637909001808 ATP binding site [chemical binding]; other site 637909001809 Walker B motif; other site 637909001810 arginine finger; other site 637909001811 UvrB/uvrC motif; Region: UVR; pfam02151 637909001812 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 637909001813 Walker A motif; other site 637909001814 ATP binding site [chemical binding]; other site 637909001815 Walker B motif; other site 637909001816 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 637909001817 Protein of unknown function (DUF3278); Region: DUF3278; pfam11683 637909001818 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 637909001819 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 637909001820 non-specific DNA binding site [nucleotide binding]; other site 637909001821 salt bridge; other site 637909001822 sequence-specific DNA binding site [nucleotide binding]; other site 637909001823 ornithine carbamoyltransferase; Validated; Region: PRK02102 637909001824 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 637909001825 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 637909001826 Protein of unknown function (DUF1797); Region: DUF1797; cl11550 637909001827 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 637909001828 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 637909001829 dimer interface [polypeptide binding]; other site 637909001830 conserved gate region; other site 637909001831 putative PBP binding loops; other site 637909001832 ABC-ATPase subunit interface; other site 637909001833 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 637909001834 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 637909001835 Walker A/P-loop; other site 637909001836 ATP binding site [chemical binding]; other site 637909001837 Q-loop/lid; other site 637909001838 ABC transporter signature motif; other site 637909001839 Walker B; other site 637909001840 D-loop; other site 637909001841 H-loop/switch region; other site 637909001842 This entry represents the core domain of the ferrous iron (Fe2+) transport protein FeoA found in bacteria; Region: FeoA; smart00899 637909001843 Fe2+ transport system protein A [Inorganic ion transport and metabolism]; Region: FeoA; COG1918 637909001844 Fe2+ transport system protein B [Inorganic ion transport and metabolism]; Region: FeoB; COG0370 637909001845 Ferrous iron transport protein B (FeoB) family; Region: FeoB; cd01879 637909001846 G1 box; other site 637909001847 GTP/Mg2+ binding site [chemical binding]; other site 637909001848 Switch I region; other site 637909001849 G2 box; other site 637909001850 G3 box; other site 637909001851 Switch II region; other site 637909001852 G4 box; other site 637909001853 G5 box; other site 637909001854 Nucleoside recognition; Region: Gate; pfam07670 637909001855 Ferrous iron transport protein B C terminus; Region: FeoB_C; pfam07664 637909001856 Nucleoside recognition; Region: Gate; pfam07670 637909001857 bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK14179 637909001858 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763 637909001859 NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080 637909001860 homodimer interface [polypeptide binding]; other site 637909001861 NADP binding site [chemical binding]; other site 637909001862 substrate binding site [chemical binding]; other site 637909001863 B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171 637909001864 putative substrate binding site [chemical binding]; other site 637909001865 putative ATP binding site [chemical binding]; other site 637909001866 Gram-positive signal peptide, YSIRK family; Region: YSIRK_signal; TIGR01168 637909001867 Bacterial SH3 domain; Region: SH3_5; pfam08460 637909001868 GBS Bsp-like repeat; Region: GBS_Bsp-like; pfam08481 637909001869 Bacterial SH3 domain; Region: SH3_5; pfam08460 637909001870 GBS Bsp-like repeat; Region: GBS_Bsp-like; pfam08481 637909001871 GBS Bsp-like repeat; Region: GBS_Bsp-like; pfam08481 637909001872 GBS Bsp-like repeat; Region: GBS_Bsp-like; pfam08481 637909001873 GBS Bsp-like repeat; Region: GBS_Bsp-like; pfam08481 637909001874 Bacterial SH3 domain; Region: SH3_5; pfam08460 637909001875 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 637909001876 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 637909001877 exodeoxyribonuclease VII large subunit; Reviewed; Region: xseA; PRK00286 637909001878 ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489 637909001879 generic binding surface II; other site 637909001880 generic binding surface I; other site 637909001881 exodeoxyribonuclease VII small subunit; Provisional; Region: PRK00977 637909001882 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 637909001883 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 637909001884 substrate binding pocket [chemical binding]; other site 637909001885 chain length determination region; other site 637909001886 substrate-Mg2+ binding site; other site 637909001887 catalytic residues [active] 637909001888 aspartate-rich region 1; other site 637909001889 active site lid residues [active] 637909001890 aspartate-rich region 2; other site 637909001891 Predicted rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: COG1189 637909001892 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 637909001893 RNA binding surface [nucleotide binding]; other site 637909001894 FtsJ-like methyltransferase; Region: FtsJ; pfam01728 637909001895 Arginine repressor [Transcription]; Region: ArgR; COG1438 637909001896 Arginine repressor, DNA binding domain; Region: Arg_repressor; pfam01316 637909001897 Arginine repressor, C-terminal domain; Region: Arg_repressor_C; pfam02863 637909001898 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: RecN; COG0497 637909001899 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 637909001900 Walker A/P-loop; other site 637909001901 ATP binding site [chemical binding]; other site 637909001902 Q-loop/lid; other site 637909001903 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 637909001904 ABC transporter signature motif; other site 637909001905 Walker B; other site 637909001906 D-loop; other site 637909001907 H-loop/switch region; other site 637909001908 EDD domain protein, DegV family; Region: DegV; TIGR00762 637909001909 Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645 637909001910 Members of the SGNH-hydrolase superfamily, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase_YpmR_like; cd04506 637909001911 active site 637909001912 catalytic triad [active] 637909001913 oxyanion hole [active] 637909001914 Uncharacterized protein conserved in bacteria (DUF2140); Region: DUF2140; pfam09911 637909001915 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 637909001916 IHF dimer interface [polypeptide binding]; other site 637909001917 IHF - DNA interface [nucleotide binding]; other site 637909001918 amino acid/peptide transporter (Peptide:H+ symporter), bacterial; Region: yjdL_sub1_fam; TIGR00924 637909001919 POT family; Region: PTR2; cl17359 637909001920 dihydroorotate dehydrogenase (subfamily 1) family protein; Region: pyrD_sub1_fam; TIGR01037 637909001921 Dihydroorotate dehydrogenase (DHOD) class 1A FMN-binding domain. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine...; Region: DHOD_1A_like; cd04741 637909001922 active site 637909001923 FMN binding site [chemical binding]; other site 637909001924 substrate binding site [chemical binding]; other site 637909001925 catalytic residues [active] 637909001926 homodimer interface [polypeptide binding]; other site 637909001927 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 637909001928 Medium chain dehydrogenases/reductase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR5; cd08271 637909001929 putative NAD(P) binding site [chemical binding]; other site 637909001930 substrate binding site [chemical binding]; other site 637909001931 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 637909001932 dimerization interface [polypeptide binding]; other site 637909001933 putative DNA binding site [nucleotide binding]; other site 637909001934 putative Zn2+ binding site [ion binding]; other site 637909001935 heavy metal-(Cd/Co/Hg/Pb/Zn)-translocating P-type ATPase; Region: ATPase-IB2_Cd; TIGR01512 637909001936 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 637909001937 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 637909001938 motif I; other site 637909001939 motif II; other site 637909001940 Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism]; Region: EmrE; COG2076 637909001941 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 637909001942 catalytic core [active] 637909001943 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 637909001944 Protein of unknown function (DUF3267); Region: DUF3267; pfam11667 637909001945 Predicted small molecule binding protein (contains 3H domain) [General function prediction only]; Region: COG1827 637909001946 HTH domain; Region: HTH_11; pfam08279 637909001947 3H domain; Region: 3H; pfam02829 637909001948 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 637909001949 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 637909001950 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 637909001951 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 637909001952 recombination protein RecR; Reviewed; Region: recR; PRK00076 637909001953 RecR protein; Region: RecR; pfam02132 637909001954 TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR. RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025 637909001955 putative active site [active] 637909001956 putative metal-binding site [ion binding]; other site 637909001957 tetramer interface [polypeptide binding]; other site 637909001958 D-alanyl-alanine synthetase A; Reviewed; Region: ddl; PRK01966 637909001959 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 637909001960 D-ala D-ala ligase C-terminus; Region: Dala_Dala_lig_C; pfam07478 637909001961 ECF-type riboflavin transporter, S component; Region: ECF-ribofla_trS; cl17272 637909001962 UDP-N-acetylmuramyl pentapeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurF; COG0770 637909001963 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 637909001964 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 637909001965 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 637909001966 O-Antigen ligase; Region: Wzy_C; cl04850 637909001967 peptide chain release factor 3; Provisional; Region: prfC; PRK00741 637909001968 Release Factor 3 (RF3) protein involved in the terminal step of translocation in bacteria; Region: RF3; cd04169 637909001969 G1 box; other site 637909001970 putative GEF interaction site [polypeptide binding]; other site 637909001971 GTP/Mg2+ binding site [chemical binding]; other site 637909001972 Switch I region; other site 637909001973 G2 box; other site 637909001974 G3 box; other site 637909001975 Switch II region; other site 637909001976 G4 box; other site 637909001977 G5 box; other site 637909001978 RF3_II: this subfamily represents the domain II of bacterial Release Factor 3 (RF3). Termination of protein synthesis by the ribosome requires two release factor (RF) classes. The class II RF3 is a GTPase that removes class I RFs (RF1 or RF2) from the...; Region: RF3_II; cd03689 637909001979 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 637909001980 DEAD-like helicases superfamily; Region: DEXDc; smart00487 637909001981 ATP binding site [chemical binding]; other site 637909001982 Mg++ binding site [ion binding]; other site 637909001983 motif III; other site 637909001984 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 637909001985 nucleotide binding region [chemical binding]; other site 637909001986 ATP-binding site [chemical binding]; other site 637909001987 The GIY-YIG domain of uncharacterized protein family UPF0213 related to structure-specific endonuclease SLX1; Region: GIY-YIG_UPF0213; cd10456 637909001988 GIY-YIG motif/motif A; other site 637909001989 putative active site [active] 637909001990 putative metal binding site [ion binding]; other site 637909001991 Predicted O-methyltransferase [General function prediction only]; Region: COG4123 637909001992 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 637909001993 S-adenosylmethionine binding site [chemical binding]; other site 637909001994 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 637909001995 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 637909001996 putative acyl-acceptor binding pocket; other site 637909001997 SLBB domain; Region: SLBB; pfam10531 637909001998 comEA protein; Region: comE; TIGR01259 637909001999 Helix-hairpin-helix motif; Region: HHH; pfam00633 637909002000 Domain of unknown function (DUF4131); Region: DUF4131; pfam13567 637909002001 Predicted membrane metal-binding protein [General function prediction only]; Region: ComEC; COG0658 637909002002 Competence protein; Region: Competence; pfam03772 637909002003 Predicted hydrolase (metallo-beta-lactamase superfamily) [General function prediction only]; Region: ComEC; COG2333 637909002004 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 637909002005 DNA polymerase III subunit delta; Reviewed; Region: holA; PRK05574 637909002006 DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144 637909002007 Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605 637909002008 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 637909002009 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 637909002010 hypothetical protein; Validated; Region: PRK00110 637909002011 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Provisional; Region: queA; PRK00147 637909002012 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Region: queA; TIGR00113 637909002013 CCC1-related family of proteins; Region: CCC1_like; cl00278 637909002014 VIT family; Region: VIT1; pfam01988 637909002015 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363 637909002016 GlcN6P_deaminase: Glucosamine-6-phosphate (GlcN6P) deaminase subfamily; GlcN6P deaminase catalyzes the reversible conversion of GlcN6P to D-fructose-6-phosphate (Fru6P) and ammonium. The reaction is an aldo-keto isomerization coupled with an amination or...; Region: GlcN6P_deaminase; cd01399 637909002017 active site 637909002018 trimer interface [polypeptide binding]; other site 637909002019 allosteric site; other site 637909002020 active site lid [active] 637909002021 hexamer (dimer of trimers) interface [polypeptide binding]; other site 637909002022 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 637909002023 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 637909002024 RNA binding surface [nucleotide binding]; other site 637909002025 Pseudouridine synthase, Escherichia coli RsuA like; Region: PseudoU_synth_RsuA; cd02553 637909002026 active site 637909002027 uracil binding [chemical binding]; other site 637909002028 Competence protein CoiA-like family; Region: CoiA; pfam06054 637909002029 Oligoendopeptidase F [Amino acid transport and metabolism]; Region: COG1164 637909002030 Peptidase family M3B Oligopeptidase F (PepF); Region: M3B_PepF_3; cd09608 637909002031 active site 637909002032 Zn binding site [ion binding]; other site 637909002033 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 637909002034 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 637909002035 Coenzyme A binding pocket [chemical binding]; other site 637909002036 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 637909002037 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 637909002038 motif II; other site 637909002039 Predicted O-methyltransferase [General function prediction only]; Region: COG4122 637909002040 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 637909002041 S-adenosylmethionine binding site [chemical binding]; other site 637909002042 foldase protein PrsA; Reviewed; Region: prsA; PRK01326 637909002043 alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252 637909002044 Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673 637909002045 motif 1; other site 637909002046 active site 637909002047 motif 2; other site 637909002048 motif 3; other site 637909002049 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 637909002050 DHHA1 domain; Region: DHHA1; pfam02272 637909002051 Predicted amidohydrolase [General function prediction only]; Region: COG0388 637909002052 Uncharacterized subgroup of the nitrilase superfamily (putative class 13 nitrilases); Region: nitrilase_5; cd07583 637909002053 putative active site [active] 637909002054 catalytic triad [active] 637909002055 putative dimer interface [polypeptide binding]; other site 637909002056 transaminase; Reviewed; Region: PRK08068 637909002057 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 637909002058 pyridoxal 5'-phosphate binding site [chemical binding]; other site 637909002059 homodimer interface [polypeptide binding]; other site 637909002060 catalytic residue [active] 637909002061 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 637909002062 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 637909002063 Walker A/P-loop; other site 637909002064 ATP binding site [chemical binding]; other site 637909002065 Q-loop/lid; other site 637909002066 ABC transporter signature motif; other site 637909002067 Walker B; other site 637909002068 D-loop; other site 637909002069 H-loop/switch region; other site 637909002070 N-acetyl-gamma-glutamyl-phosphate reductase; Validated; Region: argC; PRK00436 637909002071 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 637909002072 Ornithine acetyltransferase (OAT) family; also referred to as ArgJ. OAT catalyzes the first and fifth steps in arginine biosynthesis, coupling acetylation of glutamate with deacetylation of N-acetylornithine, which allows recycling of the acetyl group in...; Region: OAT; cd02152 637909002073 heterotetramer interface [polypeptide binding]; other site 637909002074 active site pocket [active] 637909002075 cleavage site 637909002076 AAK_NAGK-like: N-Acetyl-L-glutamate kinase (NAGK)-like . Included in this CD are the Escherichia coli and Pseudomonas aeruginosa type NAGKs which catalyze the phosphorylation of N-acetyl-L-glutamate (NAG) by ATP in the second step of arginine...; Region: AAK_NAGK-like; cd04238 637909002077 nucleotide binding site [chemical binding]; other site 637909002078 N-acetyl-L-glutamate binding site [chemical binding]; other site 637909002079 acetylornithine aminotransferase; Provisional; Region: PRK04260 637909002080 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 637909002081 inhibitor-cofactor binding pocket; inhibition site 637909002082 pyridoxal 5'-phosphate binding site [chemical binding]; other site 637909002083 catalytic residue [active] 637909002084 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 637909002085 Old yellow enzyme (OYE)-related FMN binding domain, group 4. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a reducing agent with oxygens, quinones, and alpha,beta-unsaturated aldehydes and ketones, and can act as...; Region: OYE_like_4_FMN; cd04735 637909002086 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 637909002087 putative active site [active] 637909002088 putative FMN binding site [chemical binding]; other site 637909002089 putative substrate binding site [chemical binding]; other site 637909002090 putative catalytic residue [active] 637909002091 Type 1 glutamine amidotransferase (GATase1)-like domain found in proteins similar to Escherichia coli Hsp31 protein; Region: GATase1_Hsp31_like; cd03141 637909002092 Putative intracellular protease/amidase [General function prediction only]; Region: ThiJ; COG0693 637909002093 potential catalytic triad [active] 637909002094 conserved cys residue [active] 637909002095 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3666 637909002096 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 637909002097 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 637909002098 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 637909002099 Helix-Turn-Helix DNA binding domain of the MerR-like transcription regulators YyaN and YraB; Region: HTH_YyaN; cd01109 637909002100 DNA binding residues [nucleotide binding] 637909002101 putative dimer interface [polypeptide binding]; other site 637909002102 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3238 637909002103 Protein of unknown function, DUF606; Region: DUF606; pfam04657 637909002104 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 637909002105 non-specific DNA binding site [nucleotide binding]; other site 637909002106 salt bridge; other site 637909002107 sequence-specific DNA binding site [nucleotide binding]; other site 637909002108 Protein of unknown function (DUF3169); Region: DUF3169; pfam11368 637909002109 riboflavin biosynthesis protein RibD; Region: eubact_ribD; TIGR00326 637909002110 Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284 637909002111 catalytic motif [active] 637909002112 Zn binding site [ion binding]; other site 637909002113 RibD C-terminal domain; Region: RibD_C; pfam01872 637909002114 riboflavin synthase subunit alpha; Provisional; Region: PRK09289 637909002115 Lumazine binding domain; Region: Lum_binding; pfam00677 637909002116 Lumazine binding domain; Region: Lum_binding; pfam00677 637909002117 bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II protein; Provisional; Region: PRK09311 637909002118 3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; pfam00926 637909002119 GTP cyclohydrolase II (RibA). GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641 637909002120 dimerization interface [polypeptide binding]; other site 637909002121 active site 637909002122 lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209 637909002123 homopentamer interface [polypeptide binding]; other site 637909002124 active site 637909002125 Transcriptional regulator [Transcription]; Region: LysR; COG0583 637909002126 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 637909002127 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 637909002128 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 637909002129 active site 637909002130 catalytic tetrad [active] 637909002131 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 637909002132 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 637909002133 active site 637909002134 catalytic tetrad [active] 637909002135 Protein of unknown function (DUF1211); Region: DUF1211; pfam06736 637909002136 Thiamine transporter protein (Thia_YuaJ); Region: Thia_YuaJ; pfam09515 637909002137 ribonucleotide-diphosphate reductase subunit beta; Provisional; Region: nrdF2; PRK13966 637909002138 Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049 637909002139 dimer interface [polypeptide binding]; other site 637909002140 putative radical transfer pathway; other site 637909002141 diiron center [ion binding]; other site 637909002142 tyrosyl radical; other site 637909002143 ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK07306 637909002144 Ribonucleotide reductase N-terminal; Region: RNR_N; pfam08343 637909002145 Class I ribonucleotide reductase; Region: RNR_I; cd01679 637909002146 active site 637909002147 dimer interface [polypeptide binding]; other site 637909002148 catalytic residues [active] 637909002149 effector binding site; other site 637909002150 R2 peptide binding site; other site 637909002151 NrdH-redoxin (NrdH) family; NrdH is a small monomeric protein with a conserved redox active CXXC motif within a TRX fold, characterized by a glutaredoxin (GRX)-like sequence and TRX-like activity profile. In vitro, it displays protein disulfide reductase...; Region: NrdH; cd02976 637909002152 catalytic residues [active] 637909002153 aconitate hydratase; Validated; Region: PRK09277 637909002154 Aconitase A catalytic domain; Region: AcnA_IRP; cd01586 637909002155 substrate binding site [chemical binding]; other site 637909002156 ligand binding site [chemical binding]; other site 637909002157 Aconitase A swivel domain. This is the major form of the TCA cycle enzyme aconitate hydratase, also known as aconitase and citrate hydro-lyase. It includes bacterial and archaeal aconitase A, and the eukaryotic cytosolic form of aconitase. This group...; Region: AcnA_IRP_Swivel; cd01580 637909002158 substrate binding site [chemical binding]; other site 637909002159 Bacillus subtilis (Bs) citrate synthase (CS)-II_like. CS catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the citric acid cycle (TCA or Krebs cycle). 2MCS catalyzes the...; Region: BSuCS-II_like; cd06110 637909002160 dimer interface [polypeptide binding]; other site 637909002161 Citrate synthase; Region: Citrate_synt; pfam00285 637909002162 active site 637909002163 citrylCoA binding site [chemical binding]; other site 637909002164 oxalacetate/citrate binding site [chemical binding]; other site 637909002165 coenzyme A binding site [chemical binding]; other site 637909002166 catalytic triad [active] 637909002167 Isocitrate/isopropylmalate dehydrogenase; Region: Iso_dh; cl00445 637909002168 isocitrate dehydrogenase; Validated; Region: PRK07362 637909002169 Predicted membrane protein [Function unknown]; Region: COG4905 637909002170 Protein of unknown function (DUF1113); Region: DUF1113; pfam06541 637909002171 The band 7 domain of flotillin (reggie) like proteins. This group contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin. Many of these band 7 domain-containing proteins are lipid raft-associated. Individual proteins of this...; Region: Band_7; cl02525 637909002172 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 637909002173 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 637909002174 active site 637909002175 motif I; other site 637909002176 motif II; other site 637909002177 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 637909002178 Transcriptional regulators [Transcription]; Region: PurR; COG1609 637909002179 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 637909002180 DNA binding site [nucleotide binding] 637909002181 domain linker motif; other site 637909002182 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 637909002183 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cl00630 637909002184 putative active site [active] 637909002185 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 637909002186 homotrimer interaction site [polypeptide binding]; other site 637909002187 putative active site [active] 637909002188 BadF/BadG/BcrA/BcrD ATPase family; Region: BcrAD_BadFG; cl17271 637909002189 Activator of 2-hydroxyglutaryl-CoA dehydratase (HSP70-class ATPase domain) [Lipid metabolism]; Region: COG1924 637909002190 BadF/BadG/BcrA/BcrD ATPase family; Region: BcrAD_BadFG; cl17271 637909002191 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 637909002192 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 637909002193 Protein of unknown function (DUF1003); Region: DUF1003; pfam06210 637909002194 Domain of unknown function (DUF4118); Region: DUF4118; pfam13493 637909002195 GAF domain; Region: GAF_3; pfam13492 637909002196 Putative NodB-like catalytic domain of uncharacterized proteins found in bacteria; Region: CE4_COG4878; cd10924 637909002197 NodB motif; other site 637909002198 putative active site [active] 637909002199 putative catalytic site [active] 637909002200 putative Zn binding site [ion binding]; other site 637909002201 This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_3; cd03813 637909002202 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 637909002203 Predicted membrane protein [Function unknown]; Region: COG4267 637909002204 CotH protein; Region: CotH; pfam08757 637909002205 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 637909002206 Interdomain contacts; other site 637909002207 Cytokine receptor motif; other site 637909002208 Polyphosphate(polyP) polymerase domain of yeast vacuolar transport chaperone (VTC) proteins VTC-2, -3 and- 4, and similar proteins; Region: PolyPPase_VTC_like; cd07750 637909002209 putative metal binding residues [ion binding]; other site 637909002210 signature motif; other site 637909002211 dimer interface [polypeptide binding]; other site 637909002212 active site 637909002213 polyP binding site; other site 637909002214 substrate binding site [chemical binding]; other site 637909002215 acceptor-phosphate pocket; other site 637909002216 UDP-glucose 4-epimerase; Region: PLN02240 637909002217 UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247 637909002218 NAD binding site [chemical binding]; other site 637909002219 homodimer interface [polypeptide binding]; other site 637909002220 active site 637909002221 substrate binding site [chemical binding]; other site 637909002222 glmZ(sRNA)-inactivating NTPase; Provisional; Region: PRK05416 637909002223 conserved hypothetical protein, cofD-related; Region: CofD_related; TIGR01826 637909002224 Family of CofD-like proteins and proteins related to YvcK; Region: CofD_YvcK; cd07044 637909002225 dimer interface [polypeptide binding]; other site 637909002226 phosphate binding site [ion binding]; other site 637909002227 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1481 637909002228 Sporulation Regulator WhiA N terminal; Region: WhiA_N; pfam10298 637909002229 Peptidase family C69; Region: Peptidase_C69; pfam03577 637909002230 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 637909002231 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 637909002232 non-specific DNA binding site [nucleotide binding]; other site 637909002233 salt bridge; other site 637909002234 sequence-specific DNA binding site [nucleotide binding]; other site 637909002235 transcriptional activator, Rgg/GadR/MutR family, C-terminal domain; Region: RGG_Cterm; TIGR01716 637909002236 Metal binding protein AcdA. These proteins have been shown to function in the ABC uptake of Zn2+ and Mn2+ and in competence for genetic transformation and adhesion. The AcdA proteins belong to the TroA superfamily of helical backbone metal receptor...; Region: AdcA; cd01017 637909002237 Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297 637909002238 metal binding site [ion binding]; metal-binding site 637909002239 YodA lipocalin-like domain; Region: YodA; pfam09223 637909002240 Polyphosphate(polyP) polymerase domain of yeast vacuolar transport chaperone (VTC) proteins VTC-2, -3 and- 4, and similar proteins; Region: PolyPPase_VTC_like; cd07750 637909002241 putative metal binding residues [ion binding]; other site 637909002242 signature motif; other site 637909002243 dimer interface [polypeptide binding]; other site 637909002244 active site 637909002245 polyP binding site; other site 637909002246 substrate binding site [chemical binding]; other site 637909002247 acceptor-phosphate pocket; other site 637909002248 Mannosyl-glycoprotein endo-beta-N-acetylglucosaminidase; Region: Glucosaminidase; cl17361 637909002249 50S ribosomal protein L31 type B; Reviewed; Region: rpmE2; PRK01678 637909002250 Exopolyphosphatase-related proteins [General function prediction only]; Region: COG0618 637909002251 DHH family; Region: DHH; pfam01368 637909002252 DHHA1 domain; Region: DHHA1; pfam02272 637909002253 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 637909002254 dimerization domain swap beta strand [polypeptide binding]; other site 637909002255 regulatory protein interface [polypeptide binding]; other site 637909002256 active site 637909002257 regulatory phosphorylation site [posttranslational modification]; other site 637909002258 Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism]; Region: PtsA; COG1080 637909002259 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 637909002260 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 637909002261 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 637909002262 NADP+-dependent non-phosphorylating glyceraldehyde 3-phosphate dehydrogenase and ALDH family 11; Region: ALDH_F11_NP-GAPDH; cd07082 637909002263 NADP-dependent glyceraldehyde-3-phosphate dehydrogenase; Provisional; Region: PLN00412 637909002264 tetrameric interface [polypeptide binding]; other site 637909002265 activator binding site; other site 637909002266 NADP binding site [chemical binding]; other site 637909002267 substrate binding site [chemical binding]; other site 637909002268 catalytic residues [active] 637909002269 Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and...; Region: PEPCK_HprK; cl00270 637909002270 active site 637909002271 metal-binding site [ion binding] 637909002272 active site 637909002273 nucleotide-binding site [chemical binding]; other site 637909002274 nucleotide-binding site [chemical binding]; other site 637909002275 Subtilisin-like serine proteases [Posttranslational modification, protein turnover, chaperones]; Region: AprE; COG1404 637909002276 Peptidase S8 family domain in Streptococcal C5a peptidases; Region: Peptidases_S8_C5a_Peptidase; cd07475 637909002277 putative active site [active] 637909002278 catalytic triad [active] 637909002279 PA_C5a_like: Protease-associated domain containing proteins like Streptococcus pyogenes C5a peptidase. This group contains various PA domain-containing proteins similar to S. pyogenes C5a, including, i) Vpr, a minor extracellular serine protease from...; Region: PA_C5a_like; cd02133 637909002280 PA/protease domain interface [polypeptide binding]; other site 637909002281 putative integrin binding motif; other site 637909002282 Peptidase S8 family domain in Streptococcal C5a peptidases; Region: Peptidases_S8_C5a_Peptidase; cd07475 637909002283 Fn3-like domain (DUF1034); Region: DUF1034; pfam06280 637909002284 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 637909002285 DEAD-like helicases superfamily; Region: DEXDc; smart00487 637909002286 ATP binding site [chemical binding]; other site 637909002287 putative Mg++ binding site [ion binding]; other site 637909002288 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 637909002289 nucleotide binding region [chemical binding]; other site 637909002290 ATP-binding site [chemical binding]; other site 637909002291 Uridine kinase [Nucleotide transport and metabolism]; Region: Udk; COG0572 637909002292 Uridine monophosphate kinase (UMPK, EC 2.7.1.48), also known as uridine kinase or uridine-cytidine kinase (UCK), catalyzes the reversible phosphoryl transfer from ATP to uridine or cytidine to yield UMP or CMP. In the primidine nucleotide-salvage pathway; Region: UMPK; cd02023 637909002293 Sugar specificity; other site 637909002294 Pyrimidine base specificity; other site 637909002295 ATP-binding site [chemical binding]; other site 637909002296 Listeria-Bacteroides repeat domain (List_Bact_rpt); Region: Flg_new; cl09714 637909002297 carbohydrate-binding modules from Bacteroides thetaiotaomicron SusE, SusF and similar proteins; Region: CBM_SusE-F_like; cl17376 637909002298 starch binding site [chemical binding]; other site 637909002299 Transcriptional regulators [Transcription]; Region: PurR; COG1609 637909002300 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 637909002301 DNA binding site [nucleotide binding] 637909002302 domain linker motif; other site 637909002303 N-terminal Early set domain associated with the catalytic domain of cyclomaltodextrinase and pullulan-degrading enzymes; Region: E_set_CDase_PDE_N; cd02857 637909002304 homodimer interface [polypeptide binding]; other site 637909002305 Alpha amylase catalytic domain found in cyclomaltodextrinases and related proteins; Region: AmyAc_CMD; cd11338 637909002306 active site 637909002307 homodimer interface [polypeptide binding]; other site 637909002308 catalytic site [active] 637909002309 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 637909002310 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 637909002311 dimer interface [polypeptide binding]; other site 637909002312 conserved gate region; other site 637909002313 putative PBP binding loops; other site 637909002314 ABC-ATPase subunit interface; other site 637909002315 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 637909002316 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 637909002317 dimer interface [polypeptide binding]; other site 637909002318 conserved gate region; other site 637909002319 putative PBP binding loops; other site 637909002320 ABC-ATPase subunit interface; other site 637909002321 Alpha amylase catalytic domain found in maltogenic amylases, cyclodextrin glycosyltransferase, and related proteins; Region: AmyAc_AmyMalt_CGTase_like; cd11320 637909002322 Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366 637909002323 Ca binding site [ion binding]; other site 637909002324 active site 637909002325 catalytic site [active] 637909002326 Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; cl02706 637909002327 IPT domain (domain D) of cyclodextrin glycosyltransferase (CGTase) and similar enzymes. These enzymes are involved in the enzymatic hydrolysis of alpha-1,4 linkages of starch polymers and belong to the glycosyl hydrolase family 13. Most consist of three...; Region: IPT_CGTD; cd00604 637909002328 The family 20 carbohydrate-binding module (CBM20), also known as the starch-binding domain, is found in a large number of starch degrading enzymes including alpha-amylase, beta-amylase, glucoamylase, and CGTase (cyclodextrin glucanotransferase). CBM20 is...; Region: CBM20; cl15347 637909002329 starch-binding site 2 [chemical binding]; other site 637909002330 starch-binding site 1 [chemical binding]; other site 637909002331 2-isopropylmalate synthase; Validated; Region: PRK00915 637909002332 2-isopropylmalate synthase (IPMS), N-terminal catalytic TIM barrel domain; Region: DRE_TIM_IPMS; cd07940 637909002333 active site 637909002334 catalytic residues [active] 637909002335 metal binding site [ion binding]; metal-binding site 637909002336 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; pfam08502 637909002337 3-isopropylmalate dehydrogenase; Provisional; Region: PRK00772 637909002338 tartrate dehydrogenase; Region: TTC; TIGR02089 637909002339 Predicted membrane protein [Function unknown]; Region: COG3326 637909002340 3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402 637909002341 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583 637909002342 substrate binding site [chemical binding]; other site 637909002343 ligand binding site [chemical binding]; other site 637909002344 isopropylmalate isomerase small subunit; Provisional; Region: leuD; PRK01641 637909002345 Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577 637909002346 substrate binding site [chemical binding]; other site 637909002347 GAF domain-containing protein [Signal transduction mechanisms]; Region: COG1956 637909002348 GAF domain; Region: GAF_2; pfam13185 637909002349 DNA polymerase III subunits gamma and tau; Validated; Region: PRK05563 637909002350 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 637909002351 Walker A motif; other site 637909002352 ATP binding site [chemical binding]; other site 637909002353 Walker B motif; other site 637909002354 arginine finger; other site 637909002355 DNA polymerase III subunits gamma and tau domain III; Region: DNA_pol3_gamma3; pfam12169 637909002356 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 637909002357 Helix-turn-helix domain; Region: HTH_38; pfam13936 637909002358 putative transposase OrfB; Reviewed; Region: PHA02517 637909002359 HTH-like domain; Region: HTH_21; pfam13276 637909002360 Integrase core domain; Region: rve; pfam00665 637909002361 Integrase core domain; Region: rve_2; pfam13333 637909002362 Protein of unknown function (DUF3272); Region: DUF3272; pfam11676 637909002363 bifunctional biotin--[acetyl-CoA-carboxylase] synthetase/biotin operon repressor; Provisional; Region: PRK11886 637909002364 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 637909002365 DNA-binding site [nucleotide binding]; DNA binding site 637909002366 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; pfam03099 637909002367 Biotin protein ligase C terminal domain; Region: BPL_C; pfam02237 637909002368 S-adenosylmethionine synthetase; Validated; Region: PRK05250 637909002369 S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438 637909002370 S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772 637909002371 S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773 637909002372 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 637909002373 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 637909002374 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 637909002375 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 637909002376 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 637909002377 hinge; other site 637909002378 active site 637909002379 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 637909002380 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 637909002381 Predicted transcriptional regulator containing CBS domains [Transcription]; Region: COG4109 637909002382 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 637909002383 DNA-binding site [nucleotide binding]; DNA binding site 637909002384 DRTGG domain; Region: DRTGG; pfam07085 637909002385 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 637909002386 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 637909002387 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 637909002388 active site 637909002389 Ribonuclease BN family enzyme [Replication, recombination, and repair]; Region: Rbn; COG1295 637909002390 Predicted membrane protein [Function unknown]; Region: COG2246 637909002391 GtrA-like protein; Region: GtrA; pfam04138 637909002392 Predicted membrane protein [Function unknown]; Region: COG4708 637909002393 NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956 637909002394 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114 637909002395 nucleotide binding pocket [chemical binding]; other site 637909002396 K-X-D-G motif; other site 637909002397 catalytic site [active] 637909002398 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 637909002399 NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119 637909002400 Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027 637909002401 Dimer interface [polypeptide binding]; other site 637909002402 BRCT sequence motif; other site 637909002403 putative lipid kinase; Reviewed; Region: PRK13055 637909002404 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 637909002405 Family 41 Carbohydrate-Binding Module from pullulanase-like enzymes; Region: CBM41_pullulanase; cd10315 637909002406 carbohydrate binding site [chemical binding]; other site 637909002407 pullulanase, type I; Region: pulA_typeI; TIGR02104 637909002408 Early set domain associated with the catalytic domain of pullulanase (also called dextrinase and alpha-dextrin endo-1,6-alpha glucosidase); Region: E_set_Pullulanase; cd02860 637909002409 Alpha amylase catalytic domain found in Pullulanase (also called dextrinase; alpha-dextrin endo-1,6-alpha glucosidase), limit dextrinase, and related proteins; Region: AmyAc_Pullulanase_LD-like; cd11341 637909002410 Ca binding site [ion binding]; other site 637909002411 active site 637909002412 catalytic site [active] 637909002413 glycogen branching enzyme; Provisional; Region: PRK12313 637909002414 N-terminal Early set domain associated with the catalytic domain of prokaryotic glycogen branching enzyme; Region: E_set_GBE_prok_N; cd02855 637909002415 Alpha amylase catalytic domain found in the Glycogen branching enzyme (also called 1,4-alpha-glucan branching enzyme); Region: AmyAc_Glg_BE; cd11322 637909002416 active site 637909002417 catalytic site [active] 637909002418 Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; pfam02806 637909002419 glucose-1-phosphate adenylyltransferase; Provisional; Region: glgC; PRK05293 637909002420 ADP-glucose pyrophosphorylase is involved in the biosynthesis of glycogen or starch; Region: ADP_Glucose_PP; cd02508 637909002421 ligand binding site; other site 637909002422 oligomer interface; other site 637909002423 Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651 637909002424 dimer interface [polypeptide binding]; other site 637909002425 N-terminal domain interface [polypeptide binding]; other site 637909002426 sulfate 1 binding site; other site 637909002427 glucose-1-phosphate adenylyltransferase, GlgD subunit; Region: glgD; TIGR02092 637909002428 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 637909002429 active site 637909002430 Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651 637909002431 dimer interface [polypeptide binding]; other site 637909002432 N-terminal domain interface [polypeptide binding]; other site 637909002433 sulfate 1 binding site; other site 637909002434 glycogen synthase; Provisional; Region: glgA; PRK00654 637909002435 This family is most closely related to the GT1 family of glycosyltransferases. Glycogen synthase catalyzes the formation and elongation of the alpha-1,4-glucose backbone using ADP-glucose, the second and key step of glycogen biosynthesis. This family...; Region: GT1_Glycogen_synthase_DULL1_like; cd03791 637909002436 ADP-binding pocket [chemical binding]; other site 637909002437 homodimer interface [polypeptide binding]; other site 637909002438 This is a family of oligosaccharide phosphorylases. It includes yeast and mammalian glycogen phosphorylases, plant starch/glucan phosphorylase, as well as the maltodextrin phosphorylases of bacteria. The members of this family catalyze the breakdown of...; Region: GT1_Glycogen_Phosphorylase; cd04300 637909002439 homodimer interface [polypeptide binding]; other site 637909002440 glycogen/starch/alpha-glucan phosphorylases; Region: P_ylase; TIGR02093 637909002441 active site pocket [active] 637909002442 F0F1 ATP synthase subunit C; Provisional; Region: PRK13467 637909002443 F0F1-type ATP synthase, subunit a [Energy production and conversion]; Region: AtpB; COG0356 637909002444 F0F1 ATP synthase subunit A; Validated; Region: PRK05815 637909002445 F0F1-type ATP synthase, subunit b [Energy production and conversion]; Region: AtpF; COG0711 637909002446 F0F1 ATP synthase subunit B; Validated; Region: PRK05759 637909002447 F0F1 ATP synthase subunit delta; Validated; Region: PRK05758 637909002448 ATP synthase delta (OSCP) subunit; Region: OSCP; pfam00213 637909002449 F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281 637909002450 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 637909002451 F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132 637909002452 beta subunit interaction interface [polypeptide binding]; other site 637909002453 Walker A motif; other site 637909002454 ATP binding site [chemical binding]; other site 637909002455 Walker B motif; other site 637909002456 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 637909002457 mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151 637909002458 core domain interface [polypeptide binding]; other site 637909002459 delta subunit interface [polypeptide binding]; other site 637909002460 epsilon subunit interface [polypeptide binding]; other site 637909002461 F0F1 ATP synthase subunit beta; Validated; Region: PRK09280 637909002462 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 637909002463 F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133 637909002464 alpha subunit interaction interface [polypeptide binding]; other site 637909002465 Walker A motif; other site 637909002466 ATP binding site [chemical binding]; other site 637909002467 Walker B motif; other site 637909002468 inhibitor binding site; inhibition site 637909002469 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 637909002470 F0F1 ATP synthase subunit epsilon; Validated; Region: atpC; PRK00571 637909002471 mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152 637909002472 gamma subunit interface [polypeptide binding]; other site 637909002473 epsilon subunit interface [polypeptide binding]; other site 637909002474 LBP interface [polypeptide binding]; other site 637909002475 Protein of unknown function (DUF1146); Region: DUF1146; cl11486 637909002476 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 637909002477 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 637909002478 hinge; other site 637909002479 active site 637909002480 DNA-directed RNA polymerase subunit beta; Region: EpuA; pfam11772 637909002481 DNA/RNA non-specific endonuclease; Region: Endonuclease_NS; smart00892 637909002482 DNA/RNA non-specific endonuclease; Region: Endonuclease_NS; pfam01223 637909002483 phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488 637909002484 Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912 637909002485 Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496 637909002486 dimer interface [polypeptide binding]; other site 637909002487 motif 1; other site 637909002488 active site 637909002489 motif 2; other site 637909002490 motif 3; other site 637909002491 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 637909002492 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 637909002493 Coenzyme A binding pocket [chemical binding]; other site 637909002494 phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629 637909002495 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 637909002496 putative tRNA-binding site [nucleotide binding]; other site 637909002497 B3/4 domain; Region: B3_4; pfam03483 637909002498 tRNA synthetase B5 domain; Region: B5; smart00874 637909002499 Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA, PheRS is an...; Region: PheRS_beta_core; cd00769 637909002500 dimer interface [polypeptide binding]; other site 637909002501 motif 1; other site 637909002502 motif 3; other site 637909002503 motif 2; other site 637909002504 Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; smart00896 637909002505 ATP-dependent nuclease subunit B; Region: rexB_recomb; TIGR02774 637909002506 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 637909002507 helicase-exonuclease AddAB, AddA subunit, Firmicutes type; Region: addA_Gpos; TIGR02785 637909002508 Part of AAA domain; Region: AAA_19; pfam13245 637909002509 Family description; Region: UvrD_C_2; pfam13538 637909002510 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 637909002511 CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311 637909002512 substrate binding site [chemical binding]; other site 637909002513 THF binding site; other site 637909002514 zinc-binding site [ion binding]; other site 637909002515 hypothetical protein; Provisional; Region: PRK07329 637909002516 Polymerase and Histidinol Phosphatase domain; Region: PHP; cl17102 637909002517 active site 637909002518 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 637909002519 Protein of unknown function (DUF3042); Region: DUF3042; pfam11240 637909002520 tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091 637909002521 tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324 637909002522 GTP-binding protein HflX; Region: GTP_HflX; TIGR03156 637909002523 GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167 637909002524 HflX GTPase family; Region: HflX; cd01878 637909002525 G1 box; other site 637909002526 GTP/Mg2+ binding site [chemical binding]; other site 637909002527 Switch I region; other site 637909002528 G2 box; other site 637909002529 G3 box; other site 637909002530 Switch II region; other site 637909002531 G4 box; other site 637909002532 G5 box; other site 637909002533 Galactose-1-phosphate uridyl transferase, N-terminal domain; Region: GalP_UDP_transf; pfam01087 637909002534 ribonuclease Z; Region: RNase_Z; TIGR02651 637909002535 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 637909002536 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 637909002537 NAD(P) binding site [chemical binding]; other site 637909002538 active site 637909002539 single-stranded-DNA-specific exonuclease RecJ; Region: recJ; TIGR00644 637909002540 DHH family; Region: DHH; pfam01368 637909002541 Single-strand DNA-specific exonuclease, C terminal domain; Region: ssDNA-exonuc_C; pfam10141 637909002542 Domain of unknown function (DUF4352); Region: DUF4352; pfam11611 637909002543 CAAX protease self-immunity; Region: Abi; pfam02517 637909002544 Linear amide C-N hydrolases, choloylglycine hydrolase family; Region: CBAH; pfam02275 637909002545 Penicillin V acylase (PVA), also known as conjugated bile salt acid hydrolase (CBAH), catalyzes the hydrolysis of penicillin V to yield 6-amino penicillanic acid (6-APA), an important key intermediate of semisynthetic penicillins. PVA has an N-terminal...; Region: Ntn_PVA; cd00542 637909002546 active site 637909002547 DinB superfamily; Region: DinB_2; pfam12867 637909002548 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 637909002549 ATP-binding cassette domain of the lipid transporters, subfamily A; Region: ABC_subfamily_A; cd03263 637909002550 Walker A/P-loop; other site 637909002551 ATP binding site [chemical binding]; other site 637909002552 Q-loop/lid; other site 637909002553 ABC transporter signature motif; other site 637909002554 Walker B; other site 637909002555 D-loop; other site 637909002556 H-loop/switch region; other site 637909002557 ABC-type Na+ efflux pump, permease component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatB; COG1668 637909002558 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 637909002559 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 637909002560 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 637909002561 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 637909002562 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 637909002563 active site 637909002564 homoserine O-succinyltransferase; Provisional; Region: PRK05368 637909002565 Type 1 glutamine amidotransferase (GATase1)-like domain found in homoserine trans-succinylase (HTS); Region: GATase1_HTS; cd03131 637909002566 proposed active site lysine [active] 637909002567 conserved cys residue [active] 637909002568 Putative primosome component and related proteins [DNA replication, recombination, and repair]; Region: DnaD; COG3935 637909002569 Replication initiation and membrane attachment; Region: DnaB_2; pfam07261 637909002570 Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177 637909002571 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 637909002572 minor groove reading motif; other site 637909002573 helix-hairpin-helix signature motif; other site 637909002574 substrate binding pocket [chemical binding]; other site 637909002575 active site 637909002576 iron-sulpphur binding domain in DNA-(apurinic or apyrimidinic site) lyase (subfamily of ENDO3); Region: FES; smart00525 637909002577 Predicted SAM-dependent methyltransferase [General function prediction only]; Region: COG2384 637909002578 Family of unknown function (DUF633); Region: DUF633; pfam04816 637909002579 Uncharacterized conserved protein [Function unknown]; Region: COG0327 637909002580 NIF3 (NGG1p interacting factor 3); Region: NIF3; pfam01784 637909002581 G1P_TT_short is the short form of glucose-1-phosphate thymidylyltransferase; Region: G1P_TT_short; cd02538 637909002582 glucose-1-phosphate thymidylyltransferase, short form; Region: rmlA; TIGR01207 637909002583 substrate binding site; other site 637909002584 tetramer interface; other site 637909002585 dTDP-4-dehydrorhamnose 3,5-epimerase and related enzymes [Cell envelope biogenesis, outer membrane]; Region: RfbC; COG1898 637909002586 dTDP-D-glucose 4,6-dehydratase [Cell envelope biogenesis, outer membrane]; Region: RfbB; COG1088 637909002587 dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246 637909002588 NAD binding site [chemical binding]; other site 637909002589 substrate binding site [chemical binding]; other site 637909002590 homodimer interface [polypeptide binding]; other site 637909002591 active site 637909002592 HD domain; Region: HD_4; pfam13328 637909002593 MutT homolog-1 (MTH1) is a member of the Nudix hydrolase superfamily. MTH1, the mammalian counterpart of MutT, hydrolyzes oxidized purine nucleoside triphosphates, such as 8-oxo-dGTP and 2-hydroxy-ATP, to monophosphates, thereby preventing the...; Region: MTH1; cd03427 637909002594 putative active site [active] 637909002595 nucleotide binding site [chemical binding]; other site 637909002596 nudix motif; other site 637909002597 putative metal binding site [ion binding]; other site 637909002598 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 637909002599 Domain of unknown function DUF20; Region: UPF0118; pfam01594 637909002600 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 637909002601 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 637909002602 TPR motif; other site 637909002603 binding surface 637909002604 Tetratricopeptide repeat; Region: TPR_12; pfam13424 637909002605 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 637909002606 binding surface 637909002607 TPR motif; other site 637909002608 Anaphase-promoting complex, cyclosome, subunit 3; Region: Apc3; pfam12895 637909002609 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 637909002610 dimerization interface [polypeptide binding]; other site 637909002611 putative DNA binding site [nucleotide binding]; other site 637909002612 putative Zn2+ binding site [ion binding]; other site 637909002613 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 637909002614 Old yellow enzyme (OYE)-related FMN binding domain, group 4. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a reducing agent with oxygens, quinones, and alpha,beta-unsaturated aldehydes and ketones, and can act as...; Region: OYE_like_4_FMN; cd04735 637909002615 putative active site [active] 637909002616 putative FMN binding site [chemical binding]; other site 637909002617 putative substrate binding site [chemical binding]; other site 637909002618 putative catalytic residue [active] 637909002619 acetolactate synthase; Reviewed; Region: PRK08617 637909002620 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 637909002621 PYR/PP interface [polypeptide binding]; other site 637909002622 dimer interface [polypeptide binding]; other site 637909002623 TPP binding site [chemical binding]; other site 637909002624 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 637909002625 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629 637909002626 TPP-binding site [chemical binding]; other site 637909002627 Alpha-acetolactate decarboxylase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: AlsD; COG3527 637909002628 amino acid transporter; Region: 2A0306; TIGR00909 637909002629 C-terminus of AA_permease; Region: AA_permease_C; pfam13906 637909002630 Fibronectin-binding protein A N-terminus (FbpA); Region: FbpA; pfam05833 637909002631 Domain of unknown function (DUF814); Region: DUF814; pfam05670 637909002632 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 637909002633 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 637909002634 Walker A/P-loop; other site 637909002635 ATP binding site [chemical binding]; other site 637909002636 Q-loop/lid; other site 637909002637 ABC transporter signature motif; other site 637909002638 Walker B; other site 637909002639 D-loop; other site 637909002640 H-loop/switch region; other site 637909002641 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 637909002642 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 637909002643 dimer interface [polypeptide binding]; other site 637909002644 conserved gate region; other site 637909002645 putative PBP binding loops; other site 637909002646 ABC-ATPase subunit interface; other site 637909002647 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 637909002648 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 637909002649 substrate binding pocket [chemical binding]; other site 637909002650 membrane-bound complex binding site; other site 637909002651 hinge residues; other site 637909002652 N-Dimethylarginine dimethylaminohydrolase [Amino acid transport and metabolism]; Region: COG1834 637909002653 Amidinotransferase; Region: Amidinotransf; pfam02274 637909002654 Histidinol-phosphate/aromatic aminotransferase and cobyric acid decarboxylase [Amino acid transport and metabolism]; Region: HisC; COG0079 637909002655 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 637909002656 pyridoxal 5'-phosphate binding site [chemical binding]; other site 637909002657 homodimer interface [polypeptide binding]; other site 637909002658 catalytic residue [active] 637909002659 Formate/glycerate dehydrogenases, D-specific 2-hydroxy acid dehydrogenases and related dehydrogenases; Region: FDH_GDH_like; cl17240 637909002660 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052 637909002661 NAD binding site [chemical binding]; other site 637909002662 M20 Peptidase Arginine utilization protein, RocB; Region: M20_ArgE_RocB; cd05654 637909002663 putative metal binding site [ion binding]; other site 637909002664 putative dimer interface [polypeptide binding]; other site 637909002665 Type I periplasmic ligand-binding domain of uncharacterized ABC-type transport systems that are predicted to be involved in the uptake of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_uncharacterized_transporter; cd06325 637909002666 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 637909002667 zinc binding site [ion binding]; other site 637909002668 putative ligand binding site [chemical binding]; other site 637909002669 Transmembrane subunit (TM) of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which are involved in the uptake of branched-chain amino acids (AAs), as well as TMs of transporters involved in the uptake of...; Region: TM_PBP1_branched-chain-AA_like; cd06574 637909002670 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 637909002671 TM-ABC transporter signature motif; other site 637909002672 ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: PhnK; COG1101 637909002673 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 637909002674 Walker A/P-loop; other site 637909002675 ATP binding site [chemical binding]; other site 637909002676 Q-loop/lid; other site 637909002677 ABC transporter signature motif; other site 637909002678 Walker B; other site 637909002679 D-loop; other site 637909002680 H-loop/switch region; other site 637909002681 type VII secretion effector, SACOL2603 family; Region: T7SS_SACOL2603; TIGR04197 637909002682 mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595 637909002683 Metallo-beta-lactamase superfamily; Region: Lactamase_B; pfam00753 637909002684 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 637909002685 Zinc-dependent metalloprotease, MMP_like subfamily. This group contains matrix metalloproteinases (MMPs), serralysins, and the astacin_like family of proteases; Region: ZnMc_MMP_like; cd04268 637909002686 active site 637909002687 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 637909002688 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 637909002689 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 637909002690 ABC transporter; Region: ABC_tran_2; pfam12848 637909002691 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 637909002692 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 637909002693 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 637909002694 non-specific DNA binding site [nucleotide binding]; other site 637909002695 salt bridge; other site 637909002696 sequence-specific DNA binding site [nucleotide binding]; other site 637909002697 transcriptional activator, Rgg/GadR/MutR family, C-terminal domain; Region: RGG_Cterm; TIGR01716 637909002698 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 637909002699 putative substrate translocation pore; other site 637909002700 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 637909002701 MarR family; Region: MarR_2; pfam12802 637909002702 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 637909002703 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 637909002704 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 637909002705 Walker A/P-loop; other site 637909002706 ATP binding site [chemical binding]; other site 637909002707 Q-loop/lid; other site 637909002708 ABC transporter signature motif; other site 637909002709 Walker B; other site 637909002710 D-loop; other site 637909002711 H-loop/switch region; other site 637909002712 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 637909002713 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 637909002714 ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254 637909002715 Walker A/P-loop; other site 637909002716 ATP binding site [chemical binding]; other site 637909002717 Q-loop/lid; other site 637909002718 ABC transporter signature motif; other site 637909002719 Walker B; other site 637909002720 D-loop; other site 637909002721 H-loop/switch region; other site 637909002722 pyruvate dehydrogenase E1 component, alpha subunit; Region: PDH_E1_alph_y; TIGR03182 637909002723 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 637909002724 tetramer interface [polypeptide binding]; other site 637909002725 TPP-binding site [chemical binding]; other site 637909002726 heterodimer interface [polypeptide binding]; other site 637909002727 phosphorylation loop region [posttranslational modification] 637909002728 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 637909002729 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 637909002730 alpha subunit interface [polypeptide binding]; other site 637909002731 TPP binding site [chemical binding]; other site 637909002732 heterodimer interface [polypeptide binding]; other site 637909002733 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 637909002734 branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856 637909002735 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 637909002736 E3 interaction surface; other site 637909002737 lipoyl attachment site [posttranslational modification]; other site 637909002738 e3 binding domain; Region: E3_binding; pfam02817 637909002739 e3 binding domain; Region: E3_binding; pfam02817 637909002740 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 637909002741 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 637909002742 E3 interaction surface; other site 637909002743 lipoyl attachment site [posttranslational modification]; other site 637909002744 dihydrolipoamide dehydrogenase; Region: lipoamide_DH; TIGR01350 637909002745 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 637909002746 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 637909002747 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 637909002748 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 637909002749 ABC-ATPase subunit interface; other site 637909002750 dimer interface [polypeptide binding]; other site 637909002751 putative PBP binding regions; other site 637909002752 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 637909002753 ABC-ATPase subunit interface; other site 637909002754 dimer interface [polypeptide binding]; other site 637909002755 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 637909002756 putative PBP binding regions; other site 637909002757 ABC-type enterochelin transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CeuD; COG4604 637909002758 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 637909002759 Walker A/P-loop; other site 637909002760 ATP binding site [chemical binding]; other site 637909002761 Q-loop/lid; other site 637909002762 ABC transporter signature motif; other site 637909002763 Walker B; other site 637909002764 D-loop; other site 637909002765 H-loop/switch region; other site 637909002766 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 637909002767 Siderophore binding protein FatB. These proteins have been shown to function as ABC-type initial receptors in the siderophore-mediated iron uptake in some eubacterial species. They belong to the TroA superfamily of periplasmic metal binding proteins...; Region: FatB; cd01140 637909002768 putative ligand binding residues [chemical binding]; other site 637909002769 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 637909002770 EamA-like transporter family; Region: EamA; pfam00892 637909002771 EamA-like transporter family; Region: EamA; pfam00892 637909002772 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 637909002773 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 637909002774 DNA-binding site [nucleotide binding]; DNA binding site 637909002775 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 637909002776 pyridoxal 5'-phosphate binding site [chemical binding]; other site 637909002777 homodimer interface [polypeptide binding]; other site 637909002778 catalytic residue [active] 637909002779 Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095 637909002780 lipoyltransferase and lipoate-protein ligase; Region: lipoyltrans; TIGR00545 637909002781 Bacterial lipoate protein ligase C-terminus; Region: Lip_prot_lig_C; pfam10437 637909002782 Transcriptional regulator [Transcription]; Region: LysR; COG0583 637909002783 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 637909002784 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 637909002785 dimerization interface [polypeptide binding]; other site 637909002786 Protein of unknown function (DUF3737); Region: DUF3737; pfam12541 637909002787 Bifunctional PLP-dependent enzyme with beta-cystathionase and maltose regulon repressor activities [Amino acid transport and metabolism]; Region: MalY; COG1168 637909002788 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 637909002789 pyridoxal 5'-phosphate binding site [chemical binding]; other site 637909002790 homodimer interface [polypeptide binding]; other site 637909002791 catalytic residue [active] 637909002792 Uncharacterized conserved protein [Function unknown]; Region: COG4925 637909002793 Uncharacterized conserved protein [Function unknown]; Region: COG4925 637909002794 Predicted flavin-nucleotide-binding protein [General function prediction only]; Region: COG3467 637909002795 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Thermotoga marina NorM; Region: MATE_NorM_like; cd13137 637909002796 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 637909002797 Pyrimidine reductase, riboflavin biosynthesis [Coenzyme metabolism]; Region: RibD; COG1985 637909002798 RibD C-terminal domain; Region: RibD_C; cl17279 637909002799 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 637909002800 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 637909002801 Hydrolases of the alpha/beta superfamily [General function prediction only]; Region: COG1073 637909002802 Domain of unknown function (DUF4353); Region: DUF4353; pfam14262 637909002803 Domain of unknown function (DUF4353); Region: DUF4353; pfam14262 637909002804 Major Facilitator Superfamily; Region: MFS_1; pfam07690 637909002805 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 637909002806 tricarballylate dehydrogenase; Validated; Region: PRK08274 637909002807 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 637909002808 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 637909002809 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 637909002810 Predicted flavoprotein [General function prediction only]; Region: COG0431 637909002811 Predicted flavoprotein [General function prediction only]; Region: COG0431 637909002812 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 637909002813 hypothetical protein; Provisional; Region: PRK04143 637909002814 ADP-ribose binding site [chemical binding]; other site 637909002815 Transcriptional regulators CsoR (copper-sensitive operon repressor), RcnR, and FrmR, and related domains; this domain superfamily was previously known as DUF156; Region: CsoR-like_DUF156; cl00846 637909002816 putative homotetramer interface [polypeptide binding]; other site 637909002817 putative homodimer interface [polypeptide binding]; other site 637909002818 putative allosteric switch controlling residues; other site 637909002819 putative metal binding site [ion binding]; other site 637909002820 putative homodimer-homodimer interface [polypeptide binding]; other site 637909002821 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 637909002822 active site residue [active] 637909002823 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 637909002824 CoA-disulfide reductase; Region: CoA_CoA_reduc; TIGR03385 637909002825 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 637909002826 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 637909002827 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125 637909002828 active site residue [active] 637909002829 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 637909002830 active site residue [active] 637909002831 Predicted HD superfamily hydrolase [General function prediction only]; Region: COG1418 637909002832 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 637909002833 Zn2+ binding site [ion binding]; other site 637909002834 Mg2+ binding site [ion binding]; other site 637909002835 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 637909002836 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 637909002837 Coenzyme A binding pocket [chemical binding]; other site 637909002838 Protein of unknown function (DUF2974); Region: DUF2974; pfam11187 637909002839 Transcriptional regulator [Transcription]; Region: LysR; COG0583 637909002840 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 637909002841 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 637909002842 dimerization interface [polypeptide binding]; other site 637909002843 Uncharacterized homolog of gamma-carboxymuconolactone decarboxylase subunit [Function unknown]; Region: COG0599 637909002844 Uncharacterized homolog of gamma-carboxymuconolactone decarboxylase subunit [Function unknown]; Region: COG0599 637909002845 short chain dehydrogenase; Provisional; Region: PRK06940 637909002846 classical (c) SDRs; Region: SDR_c; cd05233 637909002847 NAD(P) binding site [chemical binding]; other site 637909002848 active site 637909002849 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 637909002850 NADH(P)-binding; Region: NAD_binding_10; pfam13460 637909002851 NAD(P) binding site [chemical binding]; other site 637909002852 active site 637909002853 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 637909002854 Helix-Turn-Helix DNA binding domain of the MerR-like transcription regulators YyaN and YraB; Region: HTH_YyaN; cd01109 637909002855 DNA binding residues [nucleotide binding] 637909002856 putative dimer interface [polypeptide binding]; other site 637909002857 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 637909002858 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 637909002859 active site 637909002860 catalytic tetrad [active] 637909002861 Uncharacterized homolog of gamma-carboxymuconolactone decarboxylase subunit [Function unknown]; Region: COG0599 637909002862 Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1917 637909002863 Flagellin N-methylase; Region: FliB; pfam03692 637909002864 cellobiose phosphotransferase system IIC component; Reviewed; Region: celD; PRK09592 637909002865 Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455 637909002866 Glycosyl hydrolase family 1; Region: Glyco_hydro_1; cl01046 637909002867 beta-galactosidase; Region: BGL; TIGR03356 637909002868 PTS_IIB_chitobiose_lichenan: subunit IIB of enzyme II (EII) of the N,N-diacetylchitobiose-specific and lichenan-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In these systems, EII is either a lichenan- or an N; Region: PTS_IIB_chitobiose_lichenan; cd05564 637909002869 active site 637909002870 P-loop; other site 637909002871 phosphorylation site [posttranslational modification] 637909002872 methionine cluster; other site 637909002873 PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_lac; cl00166 637909002874 active site 637909002875 phosphorylation site [posttranslational modification] 637909002876 metal binding site [ion binding]; metal-binding site 637909002877 Transcriptional antiterminator [Transcription]; Region: BglG; COG3711 637909002878 HAD superfamily (subfamily IA) hydrolase, TIGR02254; Region: YjjG/YfnB 637909002879 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 637909002880 motif II; other site 637909002881 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 637909002882 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 637909002883 ligand binding site [chemical binding]; other site 637909002884 flexible hinge region; other site 637909002885 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 637909002886 non-specific DNA interactions [nucleotide binding]; other site 637909002887 DNA binding site [nucleotide binding] 637909002888 sequence specific DNA binding site [nucleotide binding]; other site 637909002889 putative cAMP binding site [chemical binding]; other site 637909002890 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 637909002891 LysR transcriptional regulator; Provisional; Region: rbcR; CHL00180 637909002892 C-terminal substrate binding domain of LysR-type transcriptional regulator CysL, which activates the transcription of the cysJI operon encoding sulfite reductase, contains the type 2 periplasmic binding fold; Region: PBP2_CysL_like; cd08420 637909002893 putative dimerization interface [polypeptide binding]; other site 637909002894 Predicted membrane protein [Function unknown]; Region: COG2855 637909002895 NAD-dependent aldehyde dehydrogenases [Energy production and conversion]; Region: PutA; COG1012 637909002896 Mycobacterium tuberculosis succinate-semialdehyde dehydrogenase 1-like; Region: ALDH_SSADH1_GabD1; cd07100 637909002897 NAD(P) binding site [chemical binding]; other site 637909002898 catalytic residues [active] 637909002899 Bacterial low temperature requirement A protein (LtrA); Region: LtrA; cl01754 637909002900 excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558 637909002901 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 637909002902 GIY-YIG motif/motif A; other site 637909002903 active site 637909002904 catalytic site [active] 637909002905 putative DNA binding site [nucleotide binding]; other site 637909002906 metal binding site [ion binding]; metal-binding site 637909002907 UvrB/uvrC motif; Region: UVR; pfam02151 637909002908 UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459 637909002909 Uncharacterized conserved protein [Function unknown]; Region: COG3603 637909002910 Family description; Region: ACT_7; pfam13840 637909002911 Nitroreductase-like family 1. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_1; cd02137 637909002912 dimer interface [polypeptide binding]; other site 637909002913 FMN binding site [chemical binding]; other site 637909002914 dipeptidase PepV; Reviewed; Region: PRK07318 637909002915 M20 Peptidase Xaa-His dipeptidase (PepV) degrades hydrophobic dipeptides; Region: M20_PepV; cd03888 637909002916 active site 637909002917 metal binding site [ion binding]; metal-binding site 637909002918 Uncharacterized subfamily of Uracil-DNA glycosylases; Region: UDG_like_1; cd10033 637909002919 putative uracil binding site [chemical binding]; other site 637909002920 putative active site [active] 637909002921 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 637909002922 Cyclic nucleotide-binding domain; Region: cNMP_binding; pfam00027 637909002923 ligand binding site [chemical binding]; other site 637909002924 flexible hinge region; other site 637909002925 Crp-like helix-turn-helix domain; Region: HTH_Crp_2; pfam13545 637909002926 tRNA modification GTPase TrmE; Reviewed; Region: trmE; PRK05291 637909002927 GTP-binding protein TrmE N-terminus; Region: TrmE_N; pfam10396 637909002928 trmE is a tRNA modification GTPase; Region: trmE; cd04164 637909002929 G1 box; other site 637909002930 GTP/Mg2+ binding site [chemical binding]; other site 637909002931 Switch I region; other site 637909002932 G2 box; other site 637909002933 Switch II region; other site 637909002934 G3 box; other site 637909002935 G4 box; other site 637909002936 G5 box; other site 637909002937 Catalytic cysteine-containing C-terminus of GTPase, MnmE; Region: GTPase_Cys_C; pfam12631 637909002938 RPI_A: Ribose 5-phosphate isomerase type A (RPI_A) subfamily; RPI catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate, the first step of the non-oxidative branch of the pentose phosphate pathway. This reaction leads to the...; Region: RPI_A; cd01398 637909002939 tetramer (dimer of dimers) interface [polypeptide binding]; other site 637909002940 active site 637909002941 dimer interface [polypeptide binding]; other site 637909002942 phosphopentomutase; Provisional; Region: PRK05362 637909002943 Metalloenzyme superfamily; Region: Metalloenzyme; pfam01676 637909002944 purine nucleoside phosphorylase; Provisional; Region: PRK08202 637909002945 GMP synthase - Glutamine amidotransferase domain [Nucleotide transport and metabolism]; Region: GuaA; COG0518 637909002946 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_1; cd01741 637909002947 catalytic triad [active] 637909002948 Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038 637909002949 Putative ClC chloride channel. Clc proteins are putative halogen ion (Cl-, Br- and I-) transporters found in eubacteria. They belong to the ClC superfamily of halogen ion channels, which share a unique double-barreled architecture and voltage-dependent...; Region: ClC_like; cd01033 637909002950 putative ion selectivity filter; other site 637909002951 putative pore gating glutamate residue; other site 637909002952 purine nucleoside phosphorylase; Reviewed; Region: deoD; PRK05819 637909002953 Uridine phosphorylase [Nucleotide transport and metabolism]; Region: Udp; COG2820 637909002954 CRISPR/Cas system-associated protein Csm6; Region: Csm6_III-A; cl09873 637909002955 Transcriptional regulator [Transcription]; Region: LysR; COG0583 637909002956 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 637909002957 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 637909002958 dimerization interface [polypeptide binding]; other site 637909002959 DNA polymerase processivity factor; Region: DNA_PPF; pfam02916 637909002960 Cell envelope-related transcriptional attenuator domain; Region: LytR_cpsA_psr; pfam03816 637909002961 Capsular polysaccharide biosynthesis protein [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: CapC; COG4464 637909002962 polysaccharide export protein, MPA1 family, Gram-positive type; Region: polys_exp_MPA1; TIGR01006 637909002963 Capsular polysaccharide biosynthesis protein [Cell envelope biogenesis, outer membrane]; Region: COG3944 637909002964 capsular exopolysaccharide family; Region: eps_fam; TIGR01007 637909002965 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 637909002966 exopolysaccharide biosynthesis polyprenyl glycosylphosphotransferase; Region: EPS_sugtrans; TIGR03025 637909002967 Bacterial sugar transferase; Region: Bac_transf; pfam02397 637909002968 This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_6; cd04955 637909002969 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 637909002970 putative glycosyl transferase; Provisional; Region: PRK10073 637909002971 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 637909002972 active site 637909002973 Protein of unknown function (DUF563); Region: DUF563; pfam04577 637909002974 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 637909002975 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 637909002976 Putative glycosyl/glycerophosphate transferases involved in teichoic acid biosynthesis TagF/TagB/EpsJ/RodC [Cell envelope biogenesis, outer membrane]; Region: TagB; COG1887 637909002977 CDP-Glycerol:Poly(glycerophosphate) glycerophosphotransferase; Region: Glyphos_transf; pfam04464 637909002978 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 637909002979 NAD(P) binding site [chemical binding]; other site 637909002980 active site 637909002981 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 637909002982 Cytidylyltransferase; Region: CTP_transf_2; pfam01467 637909002983 active site 637909002984 nucleotide binding site [chemical binding]; other site 637909002985 HIGH motif; other site 637909002986 KMSKS motif; other site 637909002987 HTH domain; Region: HTH_11; pfam08279 637909002988 putative frv operon regulatory protein; Provisional; Region: PRK09863 637909002989 PRD domain; Region: PRD; pfam00874 637909002990 PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568 637909002991 active site 637909002992 P-loop; other site 637909002993 phosphorylation site [posttranslational modification] 637909002994 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 637909002995 active site 637909002996 phosphorylation site [posttranslational modification] 637909002997 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 637909002998 active site 637909002999 phosphorylation site [posttranslational modification] 637909003000 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569 637909003001 active site 637909003002 P-loop; other site 637909003003 phosphorylation site [posttranslational modification] 637909003004 Phosphotransferase system, fructose-specific IIC component [Carbohydrate transport and metabolism]; Region: FruA; COG1299 637909003005 alpha-mannosidase; Provisional; Region: PRK09819 637909003006 N-terminal catalytic domain of Escherichia coli alpha-mannosidase MngB and its bacterial homologs; glycoside hydrolase family 38 (GH38); Region: GH38N_AMII_EcMngB_like; cd10815 637909003007 active site 637909003008 metal binding site [ion binding]; metal-binding site 637909003009 catalytic site [active] 637909003010 Alpha mannosidase, middle domain; Region: Alpha-mann_mid; smart00872 637909003011 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 637909003012 Helix-turn-helix domain; Region: HTH_38; pfam13936 637909003013 putative transposase OrfB; Reviewed; Region: PHA02517 637909003014 HTH-like domain; Region: HTH_21; pfam13276 637909003015 Integrase core domain; Region: rve; pfam00665 637909003016 Integrase core domain; Region: rve_2; pfam13333 637909003017 dihydroorotate dehydrogenase electron transfer subunit; Reviewed; Region: PRK00054 637909003018 FAD/NAD binding domain in the electron transfer subunit of dihydroorotate dehydrogenase. Dihydroorotate dehydrogenases (DHODs) catalyze the only redox reaction in pyrimidine de novo biosynthesis. They catalyze the oxidation of (S)-dihydroorotate to...; Region: DHOD_e_trans; cd06218 637909003019 FAD binding pocket [chemical binding]; other site 637909003020 FAD binding motif [chemical binding]; other site 637909003021 phosphate binding motif [ion binding]; other site 637909003022 beta-alpha-beta structure motif; other site 637909003023 NAD binding pocket [chemical binding]; other site 637909003024 Iron coordination center [ion binding]; other site 637909003025 dihydroorotate dehydrogenase (subfamily 1) family protein; Region: pyrD_sub1_fam; TIGR01037 637909003026 Dihydroorotate dehydrogenase (DHOD) class 1B FMN-binding domain. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine...; Region: DHOD_1B_like; cd04740 637909003027 heterodimer interface [polypeptide binding]; other site 637909003028 active site 637909003029 FMN binding site [chemical binding]; other site 637909003030 homodimer interface [polypeptide binding]; other site 637909003031 substrate binding site [chemical binding]; other site 637909003032 Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725 637909003033 active site 637909003034 dimer interface [polypeptide binding]; other site 637909003035 Inorganic pyrophosphatase. These enzymes hydrolyze inorganic pyrophosphate (PPi) to two molecules of orthophosphates (Pi). The reaction requires bivalent cations. The enzymes in general exist as homooligomers; Region: pyrophosphatase; cl00217 637909003036 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 637909003037 active site 637909003038 PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in bacteria and archaea; Region: PEBP_bact_arch; cd00865 637909003039 substrate binding site [chemical binding]; other site 637909003040 Family 1 of Uracil-DNA glycosylase (UDG) enzymes; Region: UDG_F1; cd10027 637909003041 ligand binding site [chemical binding]; other site 637909003042 active site 637909003043 UGI interface [polypeptide binding]; other site 637909003044 catalytic site [active] 637909003045 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 637909003046 conserved cys residue [active] 637909003047 dihydroorotase; Validated; Region: pyrC; PRK09357 637909003048 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 637909003049 Dihydroorotase (DHOase), subgroup IIa; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This subgroup also contains proteins that lack the active site, like unc-33, a C; Region: DHOase_IIa; cd01317 637909003050 active site 637909003051 putative glycerol-3-phosphate acyltransferase PlsY; Provisional; Region: PRK00220 637909003052 DNA topoisomerase IV, B subunit, Gram-positive; Region: parE_Gpos; TIGR01058 637909003053 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 637909003054 Mg2+ binding site [ion binding]; other site 637909003055 G-X-G motif; other site 637909003056 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 637909003057 anchoring element; other site 637909003058 dimer interface [polypeptide binding]; other site 637909003059 ATP binding site [chemical binding]; other site 637909003060 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 637909003061 active site 637909003062 putative metal-binding site [ion binding]; other site 637909003063 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 637909003064 DNA topoisomerase IV, A subunit, Gram-positive; Region: parC_Gpos; TIGR01061 637909003065 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 637909003066 CAP-like domain; other site 637909003067 active site 637909003068 primary dimer interface [polypeptide binding]; other site 637909003069 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 637909003070 branched-chain amino acid aminotransferase; Provisional; Region: PRK13357 637909003071 BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557 637909003072 homodimer interface [polypeptide binding]; other site 637909003073 substrate-cofactor binding pocket; other site 637909003074 catalytic residue [active] 637909003075 Protein of unknown function (DUF2969); Region: DUF2969; pfam11184 637909003076 30S ribosomal protein S1; Reviewed; Region: rpsA; PRK06676 637909003077 S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687 637909003078 RNA binding site [nucleotide binding]; other site 637909003079 S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465 637909003080 RNA binding site [nucleotide binding]; other site 637909003081 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 637909003082 RNA binding site [nucleotide binding]; other site 637909003083 S1_RPS1_repeat_hs4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_hs4; cd05692 637909003084 RNA binding site [nucleotide binding]; other site 637909003085 LrgB-like family; Region: LrgB; pfam04172 637909003086 Putative effector of murein hydrolase LrgA [General function prediction only]; Region: COG1380 637909003087 Uncharacterized conserved protein [Function unknown]; Region: COG0398 637909003088 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 637909003089 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 637909003090 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 637909003091 Walker A/P-loop; other site 637909003092 ATP binding site [chemical binding]; other site 637909003093 Q-loop/lid; other site 637909003094 ABC transporter signature motif; other site 637909003095 Walker B; other site 637909003096 D-loop; other site 637909003097 H-loop/switch region; other site 637909003098 Predicted transcriptional regulators [Transcription]; Region: COG1725 637909003099 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 637909003100 DNA-binding site [nucleotide binding]; DNA binding site 637909003101 DNA polymerase III DnaE; Reviewed; Region: dnaE; PRK07279 637909003102 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III; Region: PHP_PolIIIA; cd07431 637909003103 active site 637909003104 PHP Thumb interface [polypeptide binding]; other site 637909003105 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 637909003106 generic binding surface II; other site 637909003107 generic binding surface I; other site 637909003108 6-phosphofructokinase; Provisional; Region: PRK03202 637909003109 6-phosphofructokinase; Region: PFKA_ATP; TIGR02482 637909003110 active site 637909003111 ADP/pyrophosphate binding site [chemical binding]; other site 637909003112 dimerization interface [polypeptide binding]; other site 637909003113 allosteric effector site; other site 637909003114 fructose-1,6-bisphosphate binding site; other site 637909003115 pyruvate kinase; Provisional; Region: PRK05826 637909003116 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342 637909003117 domain interfaces; other site 637909003118 active site 637909003119 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 637909003120 The S24, S26 LexA/signal peptidase superfamily contains LexA-related and type I signal peptidase families. The S24 LexA protein domains include: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC 3.4.21.88), the...; Region: Peptidase_S24_S26; cl10465 637909003121 Catalytic site [active] 637909003122 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 637909003123 glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331 637909003124 Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans). The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714 637909003125 glutaminase active site [active] 637909003126 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 637909003127 dimer interface [polypeptide binding]; other site 637909003128 active site 637909003129 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 637909003130 dimer interface [polypeptide binding]; other site 637909003131 active site 637909003132 Phosphotransferase system, mannitol-specific IIBC component [Carbohydrate transport and metabolism]; Region: MtlA; COG2213 637909003133 PTS system, mannitol-specific IIC component; Region: mtlA; TIGR00851 637909003134 PTS_IIB_mannitol: subunit IIB of enzyme II (EII) of the mannitol-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is a mannitol-specific permease with two cytoplasmic domains (IIA and IIB) and a transmembrane...; Region: PTS_IIB_mannitol; cd05567 637909003135 active site 637909003136 P-loop; other site 637909003137 phosphorylation site [posttranslational modification] 637909003138 PTS_IIB_mannitol: subunit IIB of enzyme II (EII) of the mannitol-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is a mannitol-specific permease with two cytoplasmic domains (IIA and IIB) and a transmembrane...; Region: PTS_IIB_mannitol; cd05567 637909003139 active site 637909003140 P-loop; other site 637909003141 phosphorylation site [posttranslational modification] 637909003142 Transcriptional antiterminator [Transcription]; Region: BglG; COG3711 637909003143 HTH domain; Region: HTH_11; pfam08279 637909003144 HTH domain; Region: HTH_11; pfam08279 637909003145 PTS_IIB: subunit IIB of enzyme II (EII) is the central energy-coupling domain of the phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In the multienzyme PTS complex, EII is a carbohydrate-specific permease consisting of two cytoplasmic...; Region: PTS_IIB; cl10014 637909003146 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cl00163 637909003147 active site 637909003148 phosphorylation site [posttranslational modification] 637909003149 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 637909003150 active site 637909003151 phosphorylation site [posttranslational modification] 637909003152 mannitol-1-phosphate 5-dehydrogenase; Provisional; Region: PRK02318 637909003153 Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232 637909003154 Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125 637909003155 Uncharacterized Zn-ribbon-containing protein involved in phosphonate metabolism [Inorganic ion transport and metabolism]; Region: PhnA; COG2824 637909003156 PhnA Zinc-Ribbon; Region: PhnA_Zn_Ribbon; pfam08274 637909003157 PhnA protein; Region: PhnA; pfam03831 637909003158 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 637909003159 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 637909003160 dimer interface [polypeptide binding]; other site 637909003161 conserved gate region; other site 637909003162 ABC-ATPase subunit interface; other site 637909003163 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 637909003164 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 637909003165 Walker A/P-loop; other site 637909003166 ATP binding site [chemical binding]; other site 637909003167 Q-loop/lid; other site 637909003168 ABC transporter signature motif; other site 637909003169 Walker B; other site 637909003170 D-loop; other site 637909003171 H-loop/switch region; other site 637909003172 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 637909003173 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 637909003174 substrate binding pocket [chemical binding]; other site 637909003175 membrane-bound complex binding site; other site 637909003176 hinge residues; other site 637909003177 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 637909003178 cation diffusion facilitator family transporter; Region: CDF; TIGR01297 637909003179 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4994 637909003180 Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115 637909003181 Sodium:alanine symporter family; Region: Na_Ala_symp; cl00548 637909003182 Glycosyl hydrolase family 1; Region: Glyco_hydro_1; cl01046 637909003183 beta-galactosidase; Region: BGL; TIGR03356 637909003184 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 637909003185 catalytic core [active] 637909003186 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 637909003187 catalytic core [active] 637909003188 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 637909003189 catalytic core [active] 637909003190 Domain of unknown function DUF20; Region: UPF0118; pfam01594 637909003191 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 637909003192 A4GalT_like proteins catalyze the addition of galactose or glucose residues to the lipooligosaccharide (LOS) or lipopolysaccharide (LPS) of the bacterial cell surface; Region: GT8_A4GalT_like; cd04194 637909003193 Glycosyl transferase family 8; Region: Glyco_transf_8; pfam01501 637909003194 Ligand binding site; other site 637909003195 metal-binding site 637909003196 hypothetical protein; Reviewed; Region: PRK00024 637909003197 Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071 637909003198 MPN+ (JAMM) motif; other site 637909003199 Zinc-binding site [ion binding]; other site 637909003200 redox-sensing transcriptional repressor Rex; Provisional; Region: PRK05472 637909003201 Putative DNA-binding protein N-terminus; Region: Put_DNA-bind_N; pfam06971 637909003202 CoA binding domain; Region: CoA_binding; pfam02629 637909003203 Putative amino acid metabolism; Region: DUF1831; pfam08866 637909003204 Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104 637909003205 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 637909003206 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 637909003207 catalytic residue [active] 637909003208 ribose-phosphate pyrophosphokinase; Provisional; Region: PRK02458 637909003209 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 637909003210 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 637909003211 active site 637909003212 Uncharacterized subgroup 1 of the CYTH-like superfamily; Region: CYTH-like_Pase_1; cd07762 637909003213 putative active site [active] 637909003214 putative metal binding residues [ion binding]; other site 637909003215 signature motif; other site 637909003216 putative triphosphate binding site [ion binding]; other site 637909003217 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 637909003218 synthetase active site [active] 637909003219 NTP binding site [chemical binding]; other site 637909003220 metal binding site [ion binding]; metal-binding site 637909003221 inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK04885 637909003222 ATP-NAD kinase; Region: NAD_kinase; pfam01513 637909003223 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 637909003224 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 637909003225 active site 637909003226 phosphotransacetylase; Reviewed; Region: eutD; PRK09653 637909003227 classical (c) SDR, subgroup 5; Region: SDR_c5; cd05346 637909003228 malonic semialdehyde reductase; Provisional; Region: PRK10538 637909003229 putative NAD(P) binding site [chemical binding]; other site 637909003230 homodimer interface [polypeptide binding]; other site 637909003231 homotetramer interface [polypeptide binding]; other site 637909003232 active site 637909003233 PAS domain; Region: PAS_10; pfam13596 637909003234 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 637909003235 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 637909003236 active site 637909003237 motif I; other site 637909003238 motif II; other site 637909003239 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 637909003240 Beta-glucosidase/6-phospho-beta-glucosidase/beta- galactosidase [Carbohydrate transport and metabolism]; Region: BglB; COG2723 637909003241 beta-galactosidase; Region: BGL; TIGR03356 637909003242 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 637909003243 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 637909003244 Walker A/P-loop; other site 637909003245 ATP binding site [chemical binding]; other site 637909003246 Q-loop/lid; other site 637909003247 ABC transporter signature motif; other site 637909003248 Walker B; other site 637909003249 D-loop; other site 637909003250 H-loop/switch region; other site 637909003251 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 637909003252 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 637909003253 FtsX-like permease family; Region: FtsX; pfam02687 637909003254 guanosine 5'-monophosphate oxidoreductase; Provisional; Region: PRK05458 637909003255 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 637909003256 active site 637909003257 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 637909003258 Predicted transcriptional regulator [Transcription]; Region: COG2378 637909003259 HTH domain; Region: HTH_11; pfam08279 637909003260 WYL domain; Region: WYL; pfam13280 637909003261 Protein of unknown function (DUF1211); Region: DUF1211; cl01421 637909003262 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 637909003263 active site 637909003264 xanthine permease; Region: pbuX; TIGR03173 637909003265 Sulfate transporter family; Region: Sulfate_transp; pfam00916 637909003266 Membrane-associated lipoprotein involved in thiamine biosynthesis [Coenzyme metabolism]; Region: ApbE; COG1477 637909003267 ApbE family; Region: ApbE; pfam02424 637909003268 4-oxalocrotonate tautomerase; Provisional; Region: PRK02289 637909003269 active site 1 [active] 637909003270 dimer interface [polypeptide binding]; other site 637909003271 hexamer interface [polypeptide binding]; other site 637909003272 active site 2 [active] 637909003273 thymidine kinase; Provisional; Region: PRK04296 637909003274 peptide chain release factor 1; Validated; Region: prfA; PRK00591 637909003275 This domain is found in peptide chain release factors; Region: PCRF; smart00937 637909003276 RF-1 domain; Region: RF-1; pfam00472 637909003277 N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328 637909003278 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 637909003279 S-adenosylmethionine binding site [chemical binding]; other site 637909003280 Putative translation factor (SUA5) [Translation, ribosomal structure and biogenesis]; Region: SUA5; COG0009 637909003281 serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011 637909003282 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378 637909003283 dimer interface [polypeptide binding]; other site 637909003284 active site 637909003285 glycine-pyridoxal phosphate binding site [chemical binding]; other site 637909003286 folate binding site [chemical binding]; other site 637909003287 37-kD nucleoid-associated bacterial protein; Region: NA37; cl15473 637909003288 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 637909003289 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 637909003290 N-acetyl-D-glucosamine binding site [chemical binding]; other site 637909003291 catalytic residue [active] 637909003292 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 637909003293 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 637909003294 ATP-binding cassette domain of multidrug resistance protein-like transporters; Region: ABCC_MRP_Like; cd03228 637909003295 Walker A/P-loop; other site 637909003296 ATP binding site [chemical binding]; other site 637909003297 Q-loop/lid; other site 637909003298 ABC transporter signature motif; other site 637909003299 Walker B; other site 637909003300 D-loop; other site 637909003301 H-loop/switch region; other site 637909003302 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 637909003303 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 637909003304 ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254 637909003305 Walker A/P-loop; other site 637909003306 ATP binding site [chemical binding]; other site 637909003307 Q-loop/lid; other site 637909003308 ABC transporter signature motif; other site 637909003309 Walker B; other site 637909003310 D-loop; other site 637909003311 H-loop/switch region; other site 637909003312 cytoplasmic alpha-amylase; Reviewed; Region: PRK09441 637909003313 Alpha amylase catalytic domain found in bacterial and fungal Alpha amylases (also called 1,4-alpha-D-glucan-4-glucanohydrolase); Region: AmyAc_bac_fung_AmyA; cd11318 637909003314 active site 637909003315 Na/Ca binding site [ion binding]; other site 637909003316 catalytic site [active] 637909003317 Domain of unknown function (DUF1939); Region: DUF1939; pfam09154 637909003318 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 637909003319 Uncharacterized conserved protein [Function unknown]; Region: COG0398 637909003320 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 637909003321 CAT RNA binding domain; Region: CAT_RBD; smart01061 637909003322 transcriptional antiterminator BglG; Provisional; Region: PRK09772 637909003323 PRD domain; Region: PRD; pfam00874 637909003324 PRD domain; Region: PRD; pfam00874 637909003325 PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_lac; cd00215 637909003326 methionine cluster; other site 637909003327 active site 637909003328 phosphorylation site [posttranslational modification] 637909003329 metal binding site [ion binding]; metal-binding site 637909003330 phosphotransferase system, lactose specific, IIC component; Region: lac_pts_IIC; TIGR00394 637909003331 Phosphotransferase system, EIIC; Region: PTS_EIIC; pfam02378 637909003332 PTS_IIB: subunit IIB of enzyme II (EII) is the central energy-coupling domain of the phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In the multienzyme PTS complex, EII is a carbohydrate-specific permease consisting of two cytoplasmic...; Region: PTS_IIB; cl10014 637909003333 active site 637909003334 P-loop; other site 637909003335 phosphorylation site [posttranslational modification] 637909003336 6-phospho-beta-galactosidase; Provisional; Region: PRK13511 637909003337 beta-galactosidase; Region: BGL; TIGR03356 637909003338 GMP synthase; Reviewed; Region: guaA; PRK00074 637909003339 Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742 637909003340 AMP/PPi binding site [chemical binding]; other site 637909003341 candidate oxyanion hole; other site 637909003342 catalytic triad [active] 637909003343 potential glutamine specificity residues [chemical binding]; other site 637909003344 The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997 637909003345 ATP Binding subdomain [chemical binding]; other site 637909003346 Dimerization subdomain; other site 637909003347 Methyltransferase domain; Region: Methyltransf_31; pfam13847 637909003348 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 637909003349 S-adenosylmethionine binding site [chemical binding]; other site 637909003350 Regulators of stationary/sporulation gene expression [Transcription]; Region: AbrB; COG2002 637909003351 looped-hinge helix DNA binding domain, AbrB family; Region: lp_hng_hel_AbrB; TIGR01439 637909003352 This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784 637909003353 glycosyltransferase, MGT family; Region: MGT; TIGR01426 637909003354 active site 637909003355 TDP-binding site; other site 637909003356 acceptor substrate-binding pocket; other site 637909003357 homodimer interface [polypeptide binding]; other site 637909003358 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 637909003359 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 637909003360 non-specific DNA binding site [nucleotide binding]; other site 637909003361 salt bridge; other site 637909003362 sequence-specific DNA binding site [nucleotide binding]; other site 637909003363 transcriptional activator, Rgg/GadR/MutR family, C-terminal domain; Region: RGG_Cterm; TIGR01716 637909003364 Glycosyl hydrolase family 70; Region: Glyco_hydro_70; pfam02324 637909003365 Alpha amylase catalytic domain family; Region: AmyAc_family; cl07893 637909003366 glucan-binding repeat; Region: glucan_65_rpt; TIGR04035 637909003367 glucan-binding repeat; Region: glucan_65_rpt; TIGR04035 637909003368 glucan-binding repeat; Region: glucan_65_rpt; TIGR04035 637909003369 glucan-binding repeat; Region: glucan_65_rpt; TIGR04035 637909003370 glucan-binding repeat; Region: glucan_65_rpt; TIGR04035 637909003371 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 637909003372 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 637909003373 non-specific DNA binding site [nucleotide binding]; other site 637909003374 salt bridge; other site 637909003375 sequence-specific DNA binding site [nucleotide binding]; other site 637909003376 transcriptional activator, Rgg/GadR/MutR family, C-terminal domain; Region: RGG_Cterm; TIGR01716 637909003377 glucan-binding repeat; Region: glucan_65_rpt; TIGR04035 637909003378 Glycosyl hydrolase family 70; Region: Glyco_hydro_70; pfam02324 637909003379 Alpha-amylase domain; Region: Aamy; smart00642 637909003380 glucan-binding repeat; Region: glucan_65_rpt; TIGR04035 637909003381 glucan-binding repeat; Region: glucan_65_rpt; TIGR04035 637909003382 glucan-binding repeat; Region: glucan_65_rpt; TIGR04035 637909003383 glucan-binding repeat; Region: glucan_65_rpt; TIGR04035 637909003384 Glucan-binding protein C; Region: GbpC; pfam08363 637909003385 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 637909003386 Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; Region: MATE_like_8; cd13134 637909003387 GIY-YIG domain of uncharacterized bacterial protein structurally related to COG3410; Region: GIY-YIG_COG3410; cd10439 637909003388 GIY-YIG motif/motif A; other site 637909003389 putative active site [active] 637909003390 putative metal binding site [ion binding]; other site 637909003391 AAA domain; Region: AAA_30; pfam13604 637909003392 Uncharacterized conserved protein (DUF2075); Region: DUF2075; pfam09848 637909003393 Uncharacterized conserved protein [Function unknown]; Region: COG3410 637909003394 AAA ATPase domain; Region: AAA_15; pfam13175 637909003395 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 637909003396 Walker A/P-loop; other site 637909003397 ATP binding site [chemical binding]; other site 637909003398 TOPRIM_OLD: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in bacterial and archaeal nucleases of the OLD (overcome lysogenization defect) family. The bacteriophage P2 OLD protein, which has DNase as well as...; Region: TOPRIM_OLD; cd01026 637909003399 putative active site [active] 637909003400 putative metal-binding site [ion binding]; other site 637909003401 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 637909003402 Part of AAA domain; Region: AAA_19; pfam13245 637909003403 Family description; Region: UvrD_C_2; pfam13538 637909003404 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 637909003405 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 637909003406 DNA-binding site [nucleotide binding]; DNA binding site 637909003407 UTRA domain; Region: UTRA; pfam07702 637909003408 type VII secretion effector, SACOL2603 family; Region: T7SS_SACOL2603; TIGR04197 637909003409 LXG domain of WXG superfamily; Region: LXG; pfam04740 637909003410 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 637909003411 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 637909003412 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 637909003413 putative active site [active] 637909003414 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 637909003415 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 637909003416 Domain of unknown function (DUF336); Region: DUF336; cl01249 637909003417 putative oxidoreductase; Provisional; Region: PRK10206 637909003418 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 637909003419 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 637909003420 Plasmid encoded toxin Txe; Region: Plasmid_Txe; cl17389 637909003421 Antitoxin Phd_YefM, type II toxin-antitoxin system; Region: PhdYeFM_antitox; pfam02604 637909003422 Putative helix-turn-helix protein, YlxM / p13 like; Region: UPF0122; pfam04297 637909003423 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 637909003424 signal recognition particle protein; Provisional; Region: PRK10867 637909003425 SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963 637909003426 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 637909003427 P loop; other site 637909003428 GTP binding site [chemical binding]; other site 637909003429 Signal peptide binding domain; Region: SRP_SPB; pfam02978 637909003430 Helix-turn-helix domain; Region: HTH_18; pfam12833 637909003431 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 637909003432 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 637909003433 Walker A/P-loop; other site 637909003434 ATP binding site [chemical binding]; other site 637909003435 Q-loop/lid; other site 637909003436 ABC transporter signature motif; other site 637909003437 Walker B; other site 637909003438 D-loop; other site 637909003439 H-loop/switch region; other site 637909003440 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 637909003441 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 637909003442 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 637909003443 Walker A/P-loop; other site 637909003444 ATP binding site [chemical binding]; other site 637909003445 Q-loop/lid; other site 637909003446 ABC transporter signature motif; other site 637909003447 Walker B; other site 637909003448 D-loop; other site 637909003449 H-loop/switch region; other site 637909003450 Hypothetical bacterial integral membrane protein (Trep_Strep); Region: Trep_Strep; cl09823 637909003451 ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619 637909003452 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 637909003453 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 637909003454 Walker A/P-loop; other site 637909003455 ATP binding site [chemical binding]; other site 637909003456 Q-loop/lid; other site 637909003457 ABC transporter signature motif; other site 637909003458 Walker B; other site 637909003459 D-loop; other site 637909003460 H-loop/switch region; other site 637909003461 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 637909003462 Walker A/P-loop; other site 637909003463 ATP binding site [chemical binding]; other site 637909003464 Q-loop/lid; other site 637909003465 ABC transporter signature motif; other site 637909003466 Walker B; other site 637909003467 D-loop; other site 637909003468 H-loop/switch region; other site 637909003469 site-specific tyrosine recombinase XerS; Reviewed; Region: xerS; PRK05084 637909003470 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 637909003471 active site 637909003472 DNA binding site [nucleotide binding] 637909003473 Int/Topo IB signature motif; other site 637909003474 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 637909003475 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 637909003476 non-specific DNA binding site [nucleotide binding]; other site 637909003477 salt bridge; other site 637909003478 sequence-specific DNA binding site [nucleotide binding]; other site 637909003479 Predicted transcriptional regulator [Transcription]; Region: COG2932 637909003480 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 637909003481 Catalytic site [active] 637909003482 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 637909003483 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 637909003484 ATP binding site [chemical binding]; other site 637909003485 G-X-G motif; other site 637909003486 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 637909003487 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 637909003488 active site 637909003489 phosphorylation site [posttranslational modification] 637909003490 intermolecular recognition site; other site 637909003491 dimerization interface [polypeptide binding]; other site 637909003492 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 637909003493 DNA binding site [nucleotide binding] 637909003494 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 637909003495 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 637909003496 Walker A/P-loop; other site 637909003497 ATP binding site [chemical binding]; other site 637909003498 Q-loop/lid; other site 637909003499 ABC transporter signature motif; other site 637909003500 Walker B; other site 637909003501 D-loop; other site 637909003502 H-loop/switch region; other site 637909003503 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 637909003504 tRNA (uracil-5-)-methyltransferase Gid; Reviewed; Region: PRK05335 637909003505 Glucose inhibited division protein A; Region: GIDA; pfam01134 637909003506 Protein of unknown function (DUF3307); Region: DUF3307; pfam11750 637909003507 DNA topoisomerase I; Validated; Region: PRK05582 637909003508 TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I. Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363 637909003509 active site 637909003510 interdomain interaction site; other site 637909003511 putative metal-binding site [ion binding]; other site 637909003512 nucleotide binding site [chemical binding]; other site 637909003513 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 637909003514 domain I; other site 637909003515 DNA binding groove [nucleotide binding] 637909003516 phosphate binding site [ion binding]; other site 637909003517 domain II; other site 637909003518 domain III; other site 637909003519 nucleotide binding site [chemical binding]; other site 637909003520 catalytic site [active] 637909003521 domain IV; other site 637909003522 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 637909003523 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 637909003524 DNA recombination-mediator protein A; Region: DNA_processg_A; pfam02481 637909003525 DNA protecting protein DprA; Region: dprA; TIGR00732 637909003526 maltose O-acetyltransferase; Provisional; Region: PRK10092 637909003527 Maltose O-acetyltransferase (MAT) and Galactoside O-acetyltransferase (GAT): MAT and GAT catalyze the CoA-dependent acetylation of the 6-hydroxyl group of their respective sugar substrates. MAT acetylates maltose and glucose exclusively at the C6...; Region: LbH_MAT_GAT; cd03357 637909003528 active site 637909003529 substrate binding site [chemical binding]; other site 637909003530 trimer interface [polypeptide binding]; other site 637909003531 CoA binding site [chemical binding]; other site 637909003532 bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182 637909003533 RNA/DNA hybrid binding site [nucleotide binding]; other site 637909003534 active site 637909003535 GTPase YlqF; Reviewed; Region: rbgA; PRK09563 637909003536 Circularly permuted YlqF GTPase; Region: YlqF; cd01856 637909003537 GTP/Mg2+ binding site [chemical binding]; other site 637909003538 G4 box; other site 637909003539 G5 box; other site 637909003540 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 637909003541 G1 box; other site 637909003542 G1 box; other site 637909003543 GTP/Mg2+ binding site [chemical binding]; other site 637909003544 Switch I region; other site 637909003545 G2 box; other site 637909003546 G2 box; other site 637909003547 G3 box; other site 637909003548 G3 box; other site 637909003549 Switch II region; other site 637909003550 Switch II region; other site 637909003551 G5 box; other site 637909003552 Protein of unknown function (DUF4231); Region: DUF4231; pfam14015 637909003553 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 637909003554 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 637909003555 dimer interface [polypeptide binding]; other site 637909003556 phosphorylation site [posttranslational modification] 637909003557 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 637909003558 ATP binding site [chemical binding]; other site 637909003559 Mg2+ binding site [ion binding]; other site 637909003560 G-X-G motif; other site 637909003561 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 637909003562 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 637909003563 active site 637909003564 phosphorylation site [posttranslational modification] 637909003565 intermolecular recognition site; other site 637909003566 dimerization interface [polypeptide binding]; other site 637909003567 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 637909003568 DNA binding site [nucleotide binding] 637909003569 lantibiotic protection ABC transporter permease subunit, MutG family; Region: lanti_perm_MutG; TIGR03733 637909003570 lantibiotic protection ABC transporter permease subunit, MutE/EpiE family; Region: lanti_perm_MutE; TIGR03732 637909003571 ATP-binding cassette domain of the bacitracin-resistance transporter; Region: ABC_BcrA_bacitracin_resist; cd03268 637909003572 gallidermin-class lantibiotic protection ABC transporter, ATP-binding subunit; Region: galliderm_ABC; TIGR03740 637909003573 Walker A/P-loop; other site 637909003574 ATP binding site [chemical binding]; other site 637909003575 Q-loop/lid; other site 637909003576 ABC transporter signature motif; other site 637909003577 Walker B; other site 637909003578 D-loop; other site 637909003579 H-loop/switch region; other site 637909003580 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 637909003581 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 637909003582 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 637909003583 ABC transporter; Region: ABC_tran_2; pfam12848 637909003584 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 637909003585 Predicted membrane protein [Function unknown]; Region: COG4720 637909003586 Pyridoxal kinase plays a key role in the synthesis of the active coenzyme pyridoxal-5'-phosphate (PLP), by catalyzing the phosphorylation of the precursor vitamin B6 in the presence of Zn2+ and ATP. Mammals are unable to synthesize PLP de novo and...; Region: pyridoxal_pyridoxamine_kinase; cd01173 637909003587 dimer interface [polypeptide binding]; other site 637909003588 pyridoxal binding site [chemical binding]; other site 637909003589 ATP binding site [chemical binding]; other site 637909003590 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 637909003591 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 637909003592 DNA-binding site [nucleotide binding]; DNA binding site 637909003593 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 637909003594 pyridoxal 5'-phosphate binding site [chemical binding]; other site 637909003595 homodimer interface [polypeptide binding]; other site 637909003596 catalytic residue [active] 637909003597 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 637909003598 Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950 637909003599 dimer interface [polypeptide binding]; other site 637909003600 active site 637909003601 catalytic residue [active] 637909003602 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 637909003603 aspartate-semialdehyde dehydrogenase; Provisional; Region: PRK14874 637909003604 Phospholipase_D-nuclease N-terminal; Region: PLDc_N; pfam13396 637909003605 Phosphatidylserine/phosphatidylglycerophosphate/car diolipin synthases and related enzymes [Lipid metabolism]; Region: Cls; COG1502 637909003606 Putative catalytic domain, repeat 1, of Streptococcus mutans uncharacterized protein SMU_988 and similar proteins; Region: PLDc_SMU_988_like_1; cd09154 637909003607 putative active site [active] 637909003608 catalytic site [active] 637909003609 Putative catalytic domain, repeat 2, of Streptococcus mutans uncharacterized protein SMU_988 and similar proteins; Region: PLDc_SMU_988_like_2; cd09160 637909003610 putative active site [active] 637909003611 catalytic site [active] 637909003612 formate--tetrahydrofolate ligase; Provisional; Region: PRK13505 637909003613 Formyltetrahydrofolate synthetase (FTHFS) catalyzes the ATP-dependent activation of formate ion via its addition to the N10 position of tetrahydrofolate. FTHFS is a highly expressed key enzyme in both the Wood-Ljungdahl pathway of autotrophic CO2...; Region: FTHFS; cd00477 637909003614 Potassium binding sites [ion binding]; other site 637909003615 Cesium cation binding sites [ion binding]; other site 637909003616 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 637909003617 DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179 637909003618 Ligand binding site; other site 637909003619 Putative Catalytic site; other site 637909003620 DXD motif; other site 637909003621 GtrA-like protein; Region: GtrA; pfam04138 637909003622 Domain of unknown function (DUF4353); Region: DUF4353; pfam14262 637909003623 Predicted periplasmic protein (DUF2233); Region: DUF2233; pfam09992 637909003624 phosphopantothenate--cysteine ligase; Validated; Region: PRK06732 637909003625 phosphopantothenoylcysteine decarboxylase; Validated; Region: PRK07313 637909003626 Flavoprotein; Region: Flavoprotein; pfam02441 637909003627 Predicted membrane protein [Function unknown]; Region: COG4684 637909003628 phosphoglucomutase-2-like protein; Provisional; Region: PTZ00150 637909003629 This CD includes PGM2 (phosphoglucomutase 2) and PGM2L1 (phosphoglucomutase 2-like 1). The mammalian PGM2 is thought to be a phosphopentomutase that catalyzes the conversion of the nucleoside breakdown products, ribose-1-phosphate and...; Region: PGM2; cd05799 637909003630 active site 637909003631 substrate binding site [chemical binding]; other site 637909003632 metal binding site [ion binding]; metal-binding site 637909003633 Mn2+ and Fe2+ transporters of the NRAMP family [Inorganic ion transport and metabolism]; Region: MntH; COG1914 637909003634 Predicted secreted protein [Function unknown]; Region: COG4086 637909003635 Protein of unknown function (DUF1002); Region: DUF1002; pfam06207 637909003636 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_1; cd08352 637909003637 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 637909003638 putative metal binding site [ion binding]; other site 637909003639 Sortase A (SrtA) or subfamily-1 sortases are cysteine transpeptidases found in gram-positive bacteria that anchor surface proteins to peptidoglycans of the bacterial cell wall envelope. They do so by catalyzing a transpeptidation reaction in which the...; Region: Sortase_A_1; cd06165 637909003640 active site 637909003641 catalytic site [active] 637909003642 DNA gyrase subunit A; Validated; Region: PRK05560 637909003643 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 637909003644 CAP-like domain; other site 637909003645 active site 637909003646 primary dimer interface [polypeptide binding]; other site 637909003647 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 637909003648 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 637909003649 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 637909003650 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 637909003651 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 637909003652 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 637909003653 L-lactate dehydrogenase; Reviewed; Region: ldh; PRK00066 637909003654 L-2-hydroxyisocapronate dehydrogenases and some bacterial L-lactate dehydrogenases; Region: HicDH_like; cd05291 637909003655 tetramer (dimer of dimers) interface [polypeptide binding]; other site 637909003656 NAD binding site [chemical binding]; other site 637909003657 dimer interface [polypeptide binding]; other site 637909003658 substrate binding site [chemical binding]; other site 637909003659 coenzyme A disulfide reductase; Reviewed; Region: PRK09564 637909003660 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 637909003661 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 637909003662 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 637909003663 putative transposase OrfB; Reviewed; Region: PHA02517 637909003664 HTH-like domain; Region: HTH_21; pfam13276 637909003665 Integrase core domain; Region: rve; pfam00665 637909003666 Integrase core domain; Region: rve_2; pfam13333 637909003667 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 637909003668 Helix-turn-helix domain; Region: HTH_38; pfam13936 637909003669 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 637909003670 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 637909003671 TM-ABC transporter signature motif; other site 637909003672 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 637909003673 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 637909003674 TM-ABC transporter signature motif; other site 637909003675 ABC-type uncharacterized transport systems, ATPase components [General function prediction only]; Region: COG3845 637909003676 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 637909003677 Walker A/P-loop; other site 637909003678 ATP binding site [chemical binding]; other site 637909003679 Q-loop/lid; other site 637909003680 ABC transporter signature motif; other site 637909003681 Walker B; other site 637909003682 D-loop; other site 637909003683 H-loop/switch region; other site 637909003684 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 637909003685 Uncharacterized ABC-type transport system, periplasmic component/surface lipoprotein [General function prediction only]; Region: Med; COG1744 637909003686 Periplasmic binding domain of basic membrane lipoprotein, PnrA, in Treponema pallidum and its homologs from other bacteria and Archaea; Region: PBP1_BmpA_PnrA_like; cd06354 637909003687 ligand binding site [chemical binding]; other site 637909003688 2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family; Region: DeoC; cd00959 637909003689 intersubunit interface [polypeptide binding]; other site 637909003690 active site 637909003691 catalytic residue [active] 637909003692 Methyltransferase domain; Region: Methyltransf_31; pfam13847 637909003693 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 637909003694 S-adenosylmethionine binding site [chemical binding]; other site 637909003695 pantothenate kinase; Provisional; Region: PRK05439 637909003696 Pantothenate kinase (PanK) catalyzes the phosphorylation of pantothenic acid to form 4'-phosphopantothenic, which is the first of five steps in coenzyme A (CoA) biosynthetic pathway. The reaction carried out by this enzyme is a key regulatory point...; Region: PanK; cd02025 637909003697 ATP-binding site [chemical binding]; other site 637909003698 CoA-binding site [chemical binding]; other site 637909003699 Mg2+-binding site [ion binding]; other site 637909003700 30S ribosomal protein S20; Reviewed; Region: rpsT; PRK00239 637909003701 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 637909003702 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 637909003703 dimer interface [polypeptide binding]; other site 637909003704 phosphorylation site [posttranslational modification] 637909003705 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 637909003706 ATP binding site [chemical binding]; other site 637909003707 Mg2+ binding site [ion binding]; other site 637909003708 G-X-G motif; other site 637909003709 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 637909003710 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 637909003711 active site 637909003712 phosphorylation site [posttranslational modification] 637909003713 intermolecular recognition site; other site 637909003714 dimerization interface [polypeptide binding]; other site 637909003715 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 637909003716 DNA binding site [nucleotide binding] 637909003717 Aminopeptidase N [Amino acid transport and metabolism]; Region: PepN; COG0308 637909003718 Peptidase M1 Aminopeptidase N family incudes tricorn interacting factor F3, Endoplasmic reticulum aminopeptidase 1 (ERAP1), Aminopeptidase Q (APQ); Region: M1_APN_2; cd09601 637909003719 Zn binding site [ion binding]; other site 637909003720 phosphate transport system regulatory protein PhoU; Region: phoU_full; TIGR02135 637909003721 PhoU domain; Region: PhoU; pfam01895 637909003722 PhoU domain; Region: PhoU; pfam01895 637909003723 phosphate transporter ATP-binding protein; Provisional; Region: PRK14239 637909003724 ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260 637909003725 Walker A/P-loop; other site 637909003726 ATP binding site [chemical binding]; other site 637909003727 Q-loop/lid; other site 637909003728 ABC transporter signature motif; other site 637909003729 Walker B; other site 637909003730 D-loop; other site 637909003731 H-loop/switch region; other site 637909003732 phosphate transporter ATP-binding protein; Provisional; Region: PRK14237 637909003733 ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260 637909003734 Walker A/P-loop; other site 637909003735 ATP binding site [chemical binding]; other site 637909003736 Q-loop/lid; other site 637909003737 ABC transporter signature motif; other site 637909003738 Walker B; other site 637909003739 D-loop; other site 637909003740 H-loop/switch region; other site 637909003741 ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstA; COG0581 637909003742 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 637909003743 dimer interface [polypeptide binding]; other site 637909003744 conserved gate region; other site 637909003745 putative PBP binding loops; other site 637909003746 ABC-ATPase subunit interface; other site 637909003747 ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstC; COG0573 637909003748 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 637909003749 dimer interface [polypeptide binding]; other site 637909003750 conserved gate region; other site 637909003751 putative PBP binding loops; other site 637909003752 ABC-ATPase subunit interface; other site 637909003753 phosphate binding protein; Region: ptsS_2; TIGR02136 637909003754 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 637909003755 rRNA (cytosine-C(5)-)-methyltransferase RsmF; Reviewed; Region: yebU; PRK11933 637909003756 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 637909003757 S-adenosylmethionine binding site [chemical binding]; other site 637909003758 pre-rRNA processing and ribosome biogenesis; Region: Nol1_Nop2_Fmu_2; pfam13636 637909003759 glutathione reductase; Validated; Region: PRK06116 637909003760 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 637909003761 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 637909003762 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 637909003763 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 637909003764 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 637909003765 catalytic residues [active] 637909003766 Uncharacterized conserved protein [Function unknown]; Region: COG1359 637909003767 Predicted divalent heavy-metal cations transporter [Inorganic ion transport and metabolism]; Region: COG0428 637909003768 ZIP Zinc transporter; Region: Zip; pfam02535 637909003769 Methyladenine glycosylase; Region: Adenine_glyco; pfam03352 637909003770 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 637909003771 Inositol-monophosphatase-like domains. This family of phosphatases is dependent on bivalent metal ions such as Mg++, and many members are inhibited by Li+ (which is thought to displace a bivalent ion in the active site). Substrates include fructose-1; Region: IMPase_like; cd01637 637909003772 active site 637909003773 hypothetical protein; Provisional; Region: PRK04387 637909003774 Arsenate Reductase (ArsC) family, Spx subfamily; Spx is a unique RNA polymerase (RNAP)-binding protein present in bacilli and some mollicutes. It inhibits transcription by binding to the C-terminal domain of the alpha subunit of RNAP, disrupting complex...; Region: ArsC_Spx; cd03032 637909003775 ArsC family; Region: ArsC; pfam03960 637909003776 putative catalytic residues [active] 637909003777 thiol/disulfide switch; other site 637909003778 bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627 637909003779 FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064 637909003780 active site 637909003781 Riboflavin kinase; Region: Flavokinase; pfam01687 637909003782 tRNA pseudouridine synthase B; Provisional; Region: truB; PRK02484 637909003783 Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573 637909003784 RNA binding site [nucleotide binding]; other site 637909003785 active site 637909003786 tRNA Pseudouridine synthase II, C terminal; Region: TruB_C; pfam09142 637909003787 Uncharacterized conserved protein [Function unknown]; Region: COG2461 637909003788 Family of unknown function (DUF438); Region: DUF438; pfam04282 637909003789 Domain of unknown function (DUF1858); Region: DUF1858; pfam08984 637909003790 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 637909003791 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 637909003792 Coenzyme A binding pocket [chemical binding]; other site 637909003793 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4487 637909003794 Uncharacterized protein conserved in bacteria (DUF2130); Region: DUF2130; pfam09903 637909003795 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 637909003796 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 637909003797 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 637909003798 Walker A/P-loop; other site 637909003799 ATP binding site [chemical binding]; other site 637909003800 Q-loop/lid; other site 637909003801 ABC transporter signature motif; other site 637909003802 Walker B; other site 637909003803 D-loop; other site 637909003804 H-loop/switch region; other site 637909003805 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 637909003806 cobalt transport protein ATP-binding subunit; Region: cbiO; TIGR01166 637909003807 Walker A/P-loop; other site 637909003808 ATP binding site [chemical binding]; other site 637909003809 Q-loop/lid; other site 637909003810 ABC transporter signature motif; other site 637909003811 Walker B; other site 637909003812 D-loop; other site 637909003813 H-loop/switch region; other site 637909003814 ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619 637909003815 Hypothetical bacterial integral membrane protein (Trep_Strep); Region: Trep_Strep; pfam09605 637909003816 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 637909003817 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 637909003818 ATP-binding cassette domain of multidrug resistance protein-like transporters; Region: ABCC_MRP_Like; cd03228 637909003819 Walker A/P-loop; other site 637909003820 ATP binding site [chemical binding]; other site 637909003821 Q-loop/lid; other site 637909003822 ABC transporter signature motif; other site 637909003823 Walker B; other site 637909003824 D-loop; other site 637909003825 H-loop/switch region; other site 637909003826 ABC-type transport system involved in cytochrome bd biosynthesis, ATPase and permease components [Energy production and conversion / Posttranslational modification, protein turnover, chaperones]; Region: CydD; COG4988 637909003827 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 637909003828 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 637909003829 Walker A/P-loop; other site 637909003830 ATP binding site [chemical binding]; other site 637909003831 Q-loop/lid; other site 637909003832 ABC transporter signature motif; other site 637909003833 Walker B; other site 637909003834 D-loop; other site 637909003835 H-loop/switch region; other site 637909003836 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 637909003837 FtsX-like permease family; Region: FtsX; pfam02687 637909003838 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 637909003839 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 637909003840 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 637909003841 Walker A/P-loop; other site 637909003842 ATP binding site [chemical binding]; other site 637909003843 Q-loop/lid; other site 637909003844 ABC transporter signature motif; other site 637909003845 Walker B; other site 637909003846 D-loop; other site 637909003847 H-loop/switch region; other site 637909003848 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 637909003849 Peroxiredoxin (PRX) family, Atypical 2-cys PRX subfamily; composed of PRXs containing peroxidatic and resolving cysteines, similar to the homodimeric thiol specific antioxidant (TSA) protein also known as TRX-dependent thiol peroxidase (Tpx). Tpx is a...; Region: PRX_Atyp2cys; cd03014 637909003850 dimer interface [polypeptide binding]; other site 637909003851 catalytic triad [active] 637909003852 peroxidatic and resolving cysteines [active] 637909003853 Kynurenine formamidase [Amino acid transport and metabolism]; Region: COG1878 637909003854 O-acetylhomoserine sulfhydrylase [Amino acid transport and metabolism]; Region: MET17; COG2873 637909003855 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 637909003856 homodimer interface [polypeptide binding]; other site 637909003857 substrate-cofactor binding pocket; other site 637909003858 pyridoxal 5'-phosphate binding site [chemical binding]; other site 637909003859 catalytic residue [active] 637909003860 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 637909003861 thiamine phosphate binding site [chemical binding]; other site 637909003862 active site 637909003863 pyrophosphate binding site [ion binding]; other site 637909003864 4-methyl-5-beta-hydroxyethylthiazole (Thz) kinase catalyzes the phosphorylation of the hydroxylgroup of Thz. A reaction that allows cells to recycle Thz into the thiamine biosynthesis pathway, as an alternative to its synthesis from cysteine, tyrosine...; Region: THZ_kinase; cd01170 637909003865 substrate binding site [chemical binding]; other site 637909003866 multimerization interface [polypeptide binding]; other site 637909003867 ATP binding site [chemical binding]; other site 637909003868 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 637909003869 dimer interface [polypeptide binding]; other site 637909003870 substrate binding site [chemical binding]; other site 637909003871 ATP binding site [chemical binding]; other site 637909003872 TENA/THI-4/PQQC family; Region: TENA_THI-4; cl15243 637909003873 Predicted hydrolase (HAD superfamily) [General function prediction only]; Region: COG1011 637909003874 ?-D-glucose-1-phosphatase; Provisional; Region: PRK09456 637909003875 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 637909003876 S-adenosylmethionine binding site [chemical binding]; other site 637909003877 Thiamine-precursor transporter protein (ThiW); Region: ThiW; pfam09512 637909003878 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 637909003879 non-specific DNA binding site [nucleotide binding]; other site 637909003880 salt bridge; other site 637909003881 sequence-specific DNA binding site [nucleotide binding]; other site 637909003882 transcriptional activator, Rgg/GadR/MutR family, C-terminal domain; Region: RGG_Cterm; TIGR01716 637909003883 ATP-dependent DNA helicase PcrA; Region: pcrA; TIGR01073 637909003884 Part of AAA domain; Region: AAA_19; pfam13245 637909003885 Family description; Region: UvrD_C_2; pfam13538 637909003886 Glutamine Amidotransferase (GATase_I) involved in pyridoxine biosynthesis; Region: GATase1_PB; cd01749 637909003887 predicted active site [active] 637909003888 catalytic triad [active] 637909003889 pyridoxal 5'-phosphate synthase, synthase subunit Pdx1; Region: TIGR00343 637909003890 PdxS is a subunit of the pyridoxal 5'-phosphate (PLP) synthase, an important enzyme in deoxyxylulose 5-phosphate (DXP)-independent pathway for de novo biosynthesis of PLP, present in some eubacteria, in archaea, fungi, plants, plasmodia, and some...; Region: pdxS; cd04727 637909003891 active site 637909003892 multimer interface [polypeptide binding]; other site 637909003893 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 637909003894 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 637909003895 DNA-binding site [nucleotide binding]; DNA binding site 637909003896 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 637909003897 pyridoxal 5'-phosphate binding site [chemical binding]; other site 637909003898 homodimer interface [polypeptide binding]; other site 637909003899 catalytic residue [active] 637909003900 Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115 637909003901 amino acid carrier protein; Region: agcS; TIGR00835 637909003902 Rrf2 family protein; Region: rrf2_super; TIGR00738 637909003903 Transcriptional regulator; Region: Rrf2; pfam02082 637909003904 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 637909003905 NADH(P)-binding; Region: NAD_binding_10; pfam13460 637909003906 NAD(P) binding site [chemical binding]; other site 637909003907 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 637909003908 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cl17915 637909003909 GBS Bsp-like repeat; Region: GBS_Bsp-like; pfam08481 637909003910 GBS Bsp-like repeat; Region: GBS_Bsp-like; pfam08481 637909003911 GBS Bsp-like repeat; Region: GBS_Bsp-like; pfam08481 637909003912 GBS Bsp-like repeat; Region: GBS_Bsp-like; pfam08481 637909003913 GBS Bsp-like repeat; Region: GBS_Bsp-like; pfam08481 637909003914 GBS Bsp-like repeat; Region: GBS_Bsp-like; pfam08481 637909003915 Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various bacteriocins (mostly non-lantibiotic); Region: Peptidase_C39_like; cl00296 637909003916 putative active site [active] 637909003917 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 637909003918 SnoaL-like domain; Region: SnoaL_4; pfam13577 637909003919 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 637909003920 Major Facilitator Superfamily; Region: MFS_1; pfam07690 637909003921 putative substrate translocation pore; other site 637909003922 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 637909003923 Glycosyl hydrolase family 1; Region: Glyco_hydro_1; cl01046 637909003924 beta-galactosidase; Region: BGL; TIGR03356 637909003925 NnaC (CMP-NeuNAc synthetase) _like subfamily of SGNH_hydrolases, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its...; Region: NnaC_like; cd01841 637909003926 active site 637909003927 catalytic triad [active] 637909003928 oxyanion hole [active] 637909003929 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 637909003930 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 637909003931 active site 637909003932 motif I; other site 637909003933 motif II; other site 637909003934 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 637909003935 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cl17915 637909003936 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 637909003937 active site 637909003938 motif I; other site 637909003939 motif II; other site 637909003940 Ras GTPase Activating Domain; Region: RasGAP; cl02569 637909003941 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 637909003942 maltose O-acetyltransferase; Provisional; Region: PRK10092 637909003943 Maltose O-acetyltransferase (MAT) and Galactoside O-acetyltransferase (GAT): MAT and GAT catalyze the CoA-dependent acetylation of the 6-hydroxyl group of their respective sugar substrates. MAT acetylates maltose and glucose exclusively at the C6...; Region: LbH_MAT_GAT; cd03357 637909003944 active site 637909003945 substrate binding site [chemical binding]; other site 637909003946 trimer interface [polypeptide binding]; other site 637909003947 CoA binding site [chemical binding]; other site 637909003948 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 637909003949 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 637909003950 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 637909003951 short chain dehydrogenase; Provisional; Region: PRK06180 637909003952 17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374 637909003953 NADP binding site [chemical binding]; other site 637909003954 active site 637909003955 steroid binding site; other site 637909003956 Uncharacterized conserved protein [Function unknown]; Region: COG3589 637909003957 Bacterial protein of unknown function (DUF871); Region: DUF871; pfam05913 637909003958 cellobiose phosphotransferase system IIC component; Reviewed; Region: celD; PRK09592 637909003959 Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455 637909003960 PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_lac; cd00215 637909003961 methionine cluster; other site 637909003962 active site 637909003963 phosphorylation site [posttranslational modification] 637909003964 metal binding site [ion binding]; metal-binding site 637909003965 Transcriptional antiterminator [Transcription]; Region: BglG; COG3711 637909003966 HTH domain; Region: HTH_11; pfam08279 637909003967 Mga helix-turn-helix domain; Region: Mga; pfam05043 637909003968 PRD domain; Region: PRD; pfam00874 637909003969 PRD domain; Region: PRD; pfam00874 637909003970 PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568 637909003971 active site 637909003972 P-loop; other site 637909003973 phosphorylation site [posttranslational modification] 637909003974 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 637909003975 active site 637909003976 phosphorylation site [posttranslational modification] 637909003977 cellobiose phosphotransferase system IIB component; Reviewed; Region: celB; PRK09590 637909003978 active site 637909003979 P-loop; other site 637909003980 phosphorylation site [posttranslational modification] 637909003981 Uncharacterized conserved protein [Function unknown]; Region: COG4095 637909003982 6-phospho-beta-glucosidase; Reviewed; Region: celA; PRK09589 637909003983 beta-galactosidase; Region: BGL; TIGR03356 637909003984 Predicted unusual protein kinase [General function prediction only]; Region: AarF; COG0661 637909003985 ABC1 family; Region: ABC1; cl17513 637909003986 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120 637909003987 active site 637909003988 ATP binding site [chemical binding]; other site 637909003989 ABC1 family; Region: ABC1; cl17513 637909003990 Uncharacterized conserved protein [Function unknown]; Region: COG3937 637909003991 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 637909003992 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 637909003993 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 637909003994 PTS system, beta-glucoside-specific IIABC component; Region: PTS-II-ABC-beta; TIGR01995 637909003995 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 637909003996 active site turn [active] 637909003997 phosphorylation site [posttranslational modification] 637909003998 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 637909003999 PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_glc; cd00210 637909004000 HPr interaction site; other site 637909004001 glycerol kinase (GK) interaction site [polypeptide binding]; other site 637909004002 active site 637909004003 phosphorylation site [posttranslational modification] 637909004004 transcriptional antiterminator BglG; Provisional; Region: PRK09772 637909004005 CAT RNA binding domain; Region: CAT_RBD; smart01061 637909004006 PRD domain; Region: PRD; pfam00874 637909004007 PRD domain; Region: PRD; pfam00874 637909004008 ClC chloride channel EriC. This domain is found in the EriC chloride transporters that mediate the extreme acid resistance response in eubacteria and archaea. This response allows bacteria to survive in the acidic environments by decarboxylation-linked...; Region: EriC; cd01031 637909004009 Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038 637909004010 Cl- selectivity filter; other site 637909004011 Cl- binding residues [ion binding]; other site 637909004012 pore gating glutamate residue; other site 637909004013 dimer interface [polypeptide binding]; other site 637909004014 H+/Cl- coupling transport residue; other site 637909004015 TrkA-C domain; Region: TrkA_C; pfam02080 637909004016 Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687 637909004017 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 637909004018 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 637909004019 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 637909004020 dimer interface [polypeptide binding]; other site 637909004021 conserved gate region; other site 637909004022 putative PBP binding loops; other site 637909004023 ABC-ATPase subunit interface; other site 637909004024 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 637909004025 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 637909004026 dimer interface [polypeptide binding]; other site 637909004027 conserved gate region; other site 637909004028 putative PBP binding loops; other site 637909004029 ABC-ATPase subunit interface; other site 637909004030 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 637909004031 ATP-binding cassette domain of the polyamine transporter; Region: ABC_PotA_N; cd03300 637909004032 Walker A/P-loop; other site 637909004033 ATP binding site [chemical binding]; other site 637909004034 Q-loop/lid; other site 637909004035 ABC transporter signature motif; other site 637909004036 Walker B; other site 637909004037 D-loop; other site 637909004038 H-loop/switch region; other site 637909004039 TOBE domain; Region: TOBE_2; pfam08402 637909004040 UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK13905 637909004041 FAD binding domain; Region: FAD_binding_4; pfam01565 637909004042 UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873 637909004043 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483 637909004044 catalytic center binding site [active] 637909004045 ATP binding site [chemical binding]; other site 637909004046 Dihydroneopterin aldolase (DHNA) and 7,8-dihydroneopterin triphosphate epimerase domain (DHNTPE); these enzymes have been designated folB and folX, respectively. Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and...; Region: DHNA_DHNTPE; cd00534 637909004047 homooctamer interface [polypeptide binding]; other site 637909004048 active site 637909004049 dihydropteroate synthase; Region: DHPS; TIGR01496 637909004050 DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739 637909004051 substrate binding pocket [chemical binding]; other site 637909004052 dimer interface [polypeptide binding]; other site 637909004053 inhibitor binding site; inhibition site 637909004054 GTP cyclohydrolase I (GTP-CH-I) catalyzes the conversion of GTP into dihydroneopterin triphosphate. The enzyme product is the precursor of tetrahydrofolate in eubacteria, fungi, and plants and of the folate analogs in methanogenic bacteria. In...; Region: GTP_cyclohydro1; cd00642 637909004055 homodecamer interface [polypeptide binding]; other site 637909004056 GTP cyclohydrolase I; Provisional; Region: PLN03044 637909004057 active site 637909004058 putative catalytic site residues [active] 637909004059 zinc binding site [ion binding]; other site 637909004060 GTP-CH-I/GFRP interaction surface; other site 637909004061 Folylpolyglutamate synthase [Coenzyme metabolism]; Region: FolC; COG0285 637909004062 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 637909004063 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 637909004064 Bacterial periplasmic substrate-binding proteins; Region: PBPb; smart00062 637909004065 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 637909004066 substrate binding pocket [chemical binding]; other site 637909004067 membrane-bound complex binding site; other site 637909004068 hinge residues; other site 637909004069 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 637909004070 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 637909004071 Walker A/P-loop; other site 637909004072 ATP binding site [chemical binding]; other site 637909004073 Q-loop/lid; other site 637909004074 ABC transporter signature motif; other site 637909004075 Walker B; other site 637909004076 D-loop; other site 637909004077 H-loop/switch region; other site 637909004078 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 637909004079 dimer interface [polypeptide binding]; other site 637909004080 conserved gate region; other site 637909004081 ABC-ATPase subunit interface; other site 637909004082 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 637909004083 dimer interface [polypeptide binding]; other site 637909004084 conserved gate region; other site 637909004085 putative PBP binding loops; other site 637909004086 ABC-ATPase subunit interface; other site 637909004087 aminodeoxychorismate synthase; Provisional; Region: PRK07508 637909004088 chorismate binding enzyme; Region: Chorismate_bind; cl10555 637909004089 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 637909004090 Aminotransferase class IV; Region: Aminotran_4; pfam01063 637909004091 substrate-cofactor binding pocket; other site 637909004092 pyridoxal 5'-phosphate binding site [chemical binding]; other site 637909004093 catalytic residue [active] 637909004094 rarD protein; Region: rarD; TIGR00688 637909004095 EamA-like transporter family; Region: EamA; pfam00892 637909004096 homoserine kinase; Provisional; Region: PRK01212 637909004097 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 637909004098 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 637909004099 homoserine dehydrogenase; Provisional; Region: PRK06349 637909004100 Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447 637909004101 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 637909004102 ACT_HSDH_Hom CD includes the C-terminal ACT domain of the NAD(P)H-dependent, homoserine dehydrogenase (HSDH) and related domains; Region: ACT_HSDH-Hom; cd04881 637909004103 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 637909004104 Putative catalytic NodB homology domain of PgaB, IcaB, and similar proteins which consist of a deformed (beta/alpha)8 barrel fold with 5- or 6-strands; Region: CE4_NodB_like_5s_6s; cd10918 637909004105 putative active site [active] 637909004106 putative metal binding site [ion binding]; other site 637909004107 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3666 637909004108 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 637909004109 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 637909004110 probable dihydroxyacetone kinase regulator; Region: DHAK_reg; TIGR02366 637909004111 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 637909004112 Transcriptional regulator C-terminal region; Region: TetR_C_8; pfam14278 637909004113 Cro/C1-type HTH DNA-binding domain; Region: HTH_26; pfam13443 637909004114 Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387 637909004115 core dimer interface [polypeptide binding]; other site 637909004116 L10 interface [polypeptide binding]; other site 637909004117 L11 interface [polypeptide binding]; other site 637909004118 putative EF-Tu interaction site [polypeptide binding]; other site 637909004119 putative EF-G interaction site [polypeptide binding]; other site 637909004120 Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797 637909004121 23S rRNA interface [nucleotide binding]; other site 637909004122 Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site 637909004123 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 637909004124 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 637909004125 Walker A motif; other site 637909004126 ATP binding site [chemical binding]; other site 637909004127 ATPases of the AAA+ class [Posttranslational modification, protein turnover, chaperones]; Region: SpoVK; COG0464 637909004128 Walker B motif; other site 637909004129 arginine finger; other site 637909004130 UvrB/uvrC motif; Region: UVR; pfam02151 637909004131 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 637909004132 Walker A motif; other site 637909004133 ATP binding site [chemical binding]; other site 637909004134 Walker B motif; other site 637909004135 arginine finger; other site 637909004136 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 637909004137 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 637909004138 endonuclease III; Region: ENDO3c; smart00478 637909004139 minor groove reading motif; other site 637909004140 helix-hairpin-helix signature motif; other site 637909004141 substrate binding pocket [chemical binding]; other site 637909004142 active site 637909004143 Protein of unknown function (DUF1275); Region: DUF1275; pfam06912 637909004144 homocysteine methyltransferase; Provisional; Region: mmuM; PRK09485 637909004145 Homocysteine S-methyltransferase; Region: S-methyl_trans; pfam02574 637909004146 S-methylmethionine transporter; Provisional; Region: PRK11387 637909004147 YihA (EngB) GTPase family; Region: YihA_EngB; cd01876 637909004148 G1 box; other site 637909004149 GTP/Mg2+ binding site [chemical binding]; other site 637909004150 Switch I region; other site 637909004151 G2 box; other site 637909004152 G3 box; other site 637909004153 Switch II region; other site 637909004154 G4 box; other site 637909004155 G5 box; other site 637909004156 ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342 637909004157 ClpX C4-type zinc finger; Region: zf-C4_ClpX; pfam06689 637909004158 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 637909004159 Walker A motif; other site 637909004160 ATP binding site [chemical binding]; other site 637909004161 Walker B motif; other site 637909004162 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 637909004163 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 637909004164 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cd00209 637909004165 folate binding site [chemical binding]; other site 637909004166 NADP+ binding site [chemical binding]; other site 637909004167 thymidylate synthase; Reviewed; Region: thyA; PRK01827 637909004168 Thymidylate synthase and pyrimidine hydroxymethylase: Thymidylate synthase (TS) and deoxycytidylate hydroxymethylase (dCMP-HMase) are homologs that catalyze analogous alkylation of C5 of pyrimidine nucleotides. Both enzymes are involved in the...; Region: TS_Pyrimidine_HMase; cd00351 637909004169 dimerization interface [polypeptide binding]; other site 637909004170 active site 637909004171 "initiating" condensing enzymes are a subclass of decarboxylating condensing enzymes, including beta-ketoacyl [ACP] synthase, type III and polyketide synthases, type III, which include chalcone synthase and related enzymes. They are...; Region: init_cond_enzymes; cd00827 637909004172 3-hydroxy-3-methylglutaryl CoA synthase, prokaryotic clade; Region: HMG-CoA-S_prok; TIGR01835 637909004173 dimer interface [polypeptide binding]; other site 637909004174 active site 637909004175 Class II hydroxymethylglutaryl-coenzyme A (HMG-CoA) reductase (HMGR); Region: HMG-CoA_reductase_classII; cd00644 637909004176 homodimer interface [polypeptide binding]; other site 637909004177 catalytic residues [active] 637909004178 NAD binding site [chemical binding]; other site 637909004179 substrate binding pocket [chemical binding]; other site 637909004180 flexible flap; other site 637909004181 Domain of unknown function (DUF1836); Region: DUF1836; pfam08876 637909004182 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 637909004183 Predicted membrane protein, hemolysin III homolog [General function prediction only]; Region: COG1272 637909004184 channel protein, hemolysin III family; Region: hlyIII; TIGR01065 637909004185 isopentenyl pyrophosphate isomerase; Provisional; Region: PRK05437 637909004186 Isopentenyl-diphosphate:dimethylallyl diphosphate isomerase type 2 (IDI-2) FMN-binding domain. Two types of IDIs have been characterized at present. The long known IDI-1 is only dependent on divalent metals for activity, whereas IDI-2 requires a metal; Region: IDI-2_FMN; cd02811 637909004187 homotetramer interface [polypeptide binding]; other site 637909004188 FMN binding site [chemical binding]; other site 637909004189 homodimer contacts [polypeptide binding]; other site 637909004190 putative active site [active] 637909004191 putative substrate binding site [chemical binding]; other site 637909004192 Mevalonate kinase [Lipid metabolism]; Region: ERG12; COG1577 637909004193 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 637909004194 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 637909004195 diphosphomevalonate decarboxylase; Region: PLN02407 637909004196 diphosphomevalonate decarboxylase; Region: mevDPdecarb; TIGR01240 637909004197 mevalonate kinase; Region: mevalon_kin; TIGR00549 637909004198 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 637909004199 Predicted glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: ECM4; COG0435 637909004200 C-terminal, alpha helical domain of Class Omega-like Glutathione S-transferases; Region: GST_C_Omega_like; cd03190 637909004201 putative dimer interface [polypeptide binding]; other site 637909004202 N-terminal domain interface [polypeptide binding]; other site 637909004203 putative substrate binding pocket (H-site) [chemical binding]; other site 637909004204 Predicted glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: ECM4; COG0435 637909004205 Glutathione S-transferase, N-terminal domain; Region: GST_N_2; pfam13409 637909004206 C-terminal, alpha helical domain of Class Omega-like Glutathione S-transferases; Region: GST_C_Omega_like; cd03190 637909004207 putative dimer interface [polypeptide binding]; other site 637909004208 N-terminal domain interface [polypeptide binding]; other site 637909004209 putative substrate binding pocket (H-site) [chemical binding]; other site 637909004210 Acetyltransferase (GNAT) domain; Region: Acetyltransf_7; pfam13508 637909004211 Coenzyme A binding pocket [chemical binding]; other site 637909004212 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 637909004213 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 637909004214 substrate binding pocket [chemical binding]; other site 637909004215 membrane-bound complex binding site; other site 637909004216 hinge residues; other site 637909004217 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 637909004218 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 637909004219 Walker A/P-loop; other site 637909004220 ATP binding site [chemical binding]; other site 637909004221 Q-loop/lid; other site 637909004222 ABC transporter signature motif; other site 637909004223 Walker B; other site 637909004224 D-loop; other site 637909004225 H-loop/switch region; other site 637909004226 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 637909004227 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 637909004228 dimer interface [polypeptide binding]; other site 637909004229 conserved gate region; other site 637909004230 putative PBP binding loops; other site 637909004231 ABC-ATPase subunit interface; other site 637909004232 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 637909004233 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 637909004234 dimer interface [polypeptide binding]; other site 637909004235 conserved gate region; other site 637909004236 putative PBP binding loops; other site 637909004237 ABC-ATPase subunit interface; other site 637909004238 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 637909004239 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 637909004240 substrate binding pocket [chemical binding]; other site 637909004241 membrane-bound complex binding site; other site 637909004242 hinge residues; other site 637909004243 The URO-D _like protein superfamily includes bacterial and eukaryotic uroporphyrinogen decarboxylases (URO-D), coenzyme M methyltransferases and other putative bacterial methyltransferases. Uroporphyrinogen decarboxylase (URO-D) decarboxylates the four...; Region: URO-D_like; cd03465 637909004244 Transcriptional regulator [Transcription]; Region: LysR; COG0583 637909004245 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 637909004246 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 637909004247 dimerization interface [polypeptide binding]; other site 637909004248 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 637909004249 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 637909004250 active site 637909004251 catalytic tetrad [active] 637909004252 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 637909004253 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 637909004254 dimer interface [polypeptide binding]; other site 637909004255 phosphorylation site [posttranslational modification] 637909004256 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 637909004257 ATP binding site [chemical binding]; other site 637909004258 Mg2+ binding site [ion binding]; other site 637909004259 G-X-G motif; other site 637909004260 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 637909004261 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 637909004262 active site 637909004263 phosphorylation site [posttranslational modification] 637909004264 intermolecular recognition site; other site 637909004265 dimerization interface [polypeptide binding]; other site 637909004266 Transcriptional regulatory protein, C terminal; Region: Trans_reg_C; smart00862 637909004267 DNA binding site [nucleotide binding] 637909004268 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 637909004269 synthetase active site [active] 637909004270 NTP binding site [chemical binding]; other site 637909004271 metal binding site [ion binding]; metal-binding site 637909004272 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 637909004273 dimer interface [polypeptide binding]; other site 637909004274 conserved gate region; other site 637909004275 ABC-ATPase subunit interface; other site 637909004276 sulfate ABC transporter, ATP-binding protein; Region: 3a0106s01; TIGR00968 637909004277 ATP-binding cassette domain of the osmoprotectant transporter; Region: ABC_OpuCA_Osmoprotection; cd03295 637909004278 Walker A/P-loop; other site 637909004279 ATP binding site [chemical binding]; other site 637909004280 Q-loop/lid; other site 637909004281 ABC transporter signature motif; other site 637909004282 Walker B; other site 637909004283 D-loop; other site 637909004284 H-loop/switch region; other site 637909004285 Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069 637909004286 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 637909004287 ABC-ATPase subunit interface; other site 637909004288 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 637909004289 MarR family; Region: MarR_2; pfam12802 637909004290 MarR family; Region: MarR_2; cl17246 637909004291 Quinone oxidoreductase (QOR); Region: quinone_oxidoreductase_like_1; cd08243 637909004292 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 637909004293 putative NAD(P) binding site [chemical binding]; other site 637909004294 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 637909004295 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 637909004296 ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254 637909004297 Walker A/P-loop; other site 637909004298 ATP binding site [chemical binding]; other site 637909004299 Q-loop/lid; other site 637909004300 ABC transporter signature motif; other site 637909004301 Walker B; other site 637909004302 D-loop; other site 637909004303 H-loop/switch region; other site 637909004304 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 637909004305 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 637909004306 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 637909004307 Walker A/P-loop; other site 637909004308 ATP binding site [chemical binding]; other site 637909004309 Q-loop/lid; other site 637909004310 ABC transporter signature motif; other site 637909004311 Walker B; other site 637909004312 D-loop; other site 637909004313 H-loop/switch region; other site 637909004314 Transcriptional regulators [Transcription]; Region: MarR; COG1846 637909004315 MarR family; Region: MarR_2; pfam12802 637909004316 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 637909004317 active site 637909004318 catalytic residues [active] 637909004319 metal binding site [ion binding]; metal-binding site 637909004320 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 637909004321 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 637909004322 Coenzyme A binding pocket [chemical binding]; other site 637909004323 glutamate dehydrogenase; Provisional; Region: PRK09414 637909004324 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 637909004325 NAD(P) binding domain of glutamate dehydrogenase, subgroup 2; Region: NAD_bind_2_Glu_DH; cd05313 637909004326 NAD(P) binding site [chemical binding]; other site 637909004327 Enzyme related to GTP cyclohydrolase I [General function prediction only]; Region: COG0780 637909004328 7-cyano-7-deazaguanosine (preQ0) biosynthesis protein QueE; Region: Bsubt_queE; TIGR03365 637909004329 putative 7-cyano-7-deazaguanosine (preQ0) biosynthesis protein QueE; Region: rSAM_QueE_Ecoli; TIGR04322 637909004330 6-pyruvoyl tetrahydropterin synthase; Region: PTPS; pfam01242 637909004331 active site 637909004332 ExsB is a transcription regulator related protein. It is a subfamily of a Adenosine nucleotide binding superfamily of proteins. This protein family is represented by a single member in nearly every completed large (> 1000 genes) prokaryotic genome. In...; Region: ExsB; cd01995 637909004333 Ligand Binding Site [chemical binding]; other site 637909004334 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 637909004335 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 637909004336 ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254 637909004337 Walker A/P-loop; other site 637909004338 ATP binding site [chemical binding]; other site 637909004339 Q-loop/lid; other site 637909004340 ABC transporter signature motif; other site 637909004341 Walker B; other site 637909004342 D-loop; other site 637909004343 H-loop/switch region; other site 637909004344 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 637909004345 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 637909004346 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 637909004347 Walker A/P-loop; other site 637909004348 ATP binding site [chemical binding]; other site 637909004349 Q-loop/lid; other site 637909004350 ABC transporter signature motif; other site 637909004351 Walker B; other site 637909004352 D-loop; other site 637909004353 H-loop/switch region; other site 637909004354 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 637909004355 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 637909004356 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 637909004357 ABC transporter; Region: ABC_tran_2; pfam12848 637909004358 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 637909004359 tRNA CCA-pyrophosphorylase; Provisional; Region: PRK13299 637909004360 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 637909004361 active site 637909004362 NTP binding site [chemical binding]; other site 637909004363 metal binding triad [ion binding]; metal-binding site 637909004364 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 637909004365 tRNA nucleotidyltransferase domain 2 putative; Region: tRNA_NucTran2_2; pfam13735 637909004366 dihydrodipicolinate reductase; Provisional; Region: PRK00048 637909004367 Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113 637909004368 Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173 637909004369 EDD domain protein, DegV family; Region: DegV; TIGR00762 637909004370 Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645 637909004371 Protein of unknown function (DUF1149); Region: DUF1149; pfam06619 637909004372 Protein of unknown function (DUF1211); Region: DUF1211; cl01421 637909004373 Muramidase (flagellum-specific) [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FlgJ; COG1705 637909004374 1-deoxy-D-xylulose-5-phosphate synthase; Provisional; Region: PRK12315 637909004375 Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007 637909004376 TPP-binding site; other site 637909004377 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 637909004378 PYR/PP interface [polypeptide binding]; other site 637909004379 dimer interface [polypeptide binding]; other site 637909004380 TPP binding site [chemical binding]; other site 637909004381 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 637909004382 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 637909004383 atypical (a) SDRs, subgroup 5; Region: SDR_a5; cd05243 637909004384 NADH(P)-binding; Region: NAD_binding_10; pfam13460 637909004385 NAD(P) binding site [chemical binding]; other site 637909004386 putative active site [active] 637909004387 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 637909004388 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 637909004389 active site 637909004390 catalytic tetrad [active] 637909004391 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 637909004392 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 637909004393 active site 637909004394 catalytic tetrad [active] 637909004395 bifunctional homocysteine S-methyltransferase/5,10-methylenetetrahydrofolate reductase protein; Reviewed; Region: PRK08645 637909004396 Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; cl14105 637909004397 Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cd00537 637909004398 FAD binding site [chemical binding]; other site 637909004399 5-methyltetrahydropteroyltriglutamate--homocysteine S-methyltransferase; Provisional; Region: PRK05222 637909004400 CIMS - Cobalamine-independent methonine synthase, or MetE, N-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_N_terminal_like; cd03312 637909004401 THF binding site; other site 637909004402 CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311 637909004403 substrate binding site [chemical binding]; other site 637909004404 THF binding site; other site 637909004405 zinc-binding site [ion binding]; other site 637909004406 PTS system 2-O-a-mannosyl-D-glycerate specific transporter subunit IIABC; Provisional; Region: PRK09765 637909004407 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 637909004408 active site 637909004409 phosphorylation site [posttranslational modification] 637909004410 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569 637909004411 active site 637909004412 P-loop; other site 637909004413 phosphorylation site [posttranslational modification] 637909004414 Phosphotransferase system, fructose-specific IIC component [Carbohydrate transport and metabolism]; Region: FruA; COG1299 637909004415 Fructose-1-phosphate kinase and related fructose-6-phosphate kinase (PfkB) [Carbohydrate transport and metabolism]; Region: FruK; COG1105 637909004416 1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164 637909004417 putative substrate binding site [chemical binding]; other site 637909004418 putative ATP binding site [chemical binding]; other site 637909004419 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 637909004420 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 637909004421 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 637909004422 Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492 637909004423 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 637909004424 Uncharacterized protein family (UPF0157); Region: UPF0157; pfam04229 637909004425 tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026 637909004426 16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK00122 637909004427 RimM N-terminal domain; Region: RimM; pfam01782 637909004428 PRC-barrel domain; Region: PRC; pfam05239 637909004429 Predicted RNA-binding protein (contains KH domain) [General function prediction only]; Region: COG1837 637909004430 KH domain; Region: KH_4; pfam13083 637909004431 G-X-X-G motif; other site 637909004432 Ribosomal protein S16 [Translation, ribosomal structure and biogenesis]; Region: RpsP; COG0228 637909004433 Putative SAM-dependent methyltransferase; Region: SAM_MT; cl17517 637909004434 Uncharacterized conserved protein [Function unknown]; Region: COG0398 637909004435 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 637909004436 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 637909004437 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 637909004438 FtsX-like permease family; Region: FtsX; pfam02687 637909004439 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 637909004440 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 637909004441 Walker A/P-loop; other site 637909004442 ATP binding site [chemical binding]; other site 637909004443 Q-loop/lid; other site 637909004444 ABC transporter signature motif; other site 637909004445 Walker B; other site 637909004446 D-loop; other site 637909004447 H-loop/switch region; other site 637909004448 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 637909004449 HlyD family secretion protein; Region: HlyD_3; pfam13437 637909004450 carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294 637909004451 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 637909004452 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 637909004453 Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787 637909004454 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 637909004455 ATP-grasp domain; Region: ATP-grasp_4; cl17255 637909004456 Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424 637909004457 IMP binding site; other site 637909004458 dimer interface [polypeptide binding]; other site 637909004459 interdomain contacts; other site 637909004460 partial ornithine binding site; other site 637909004461 carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564 637909004462 Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; smart01097 637909004463 Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744 637909004464 catalytic site [active] 637909004465 subunit interface [polypeptide binding]; other site 637909004466 aspartate carbamoyltransferase catalytic subunit; Provisional; Region: pyrB; PRK00856 637909004467 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 637909004468 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 637909004469 uracil transporter; Provisional; Region: PRK10720 637909004470 Pyrimidine operon attenuation protein/uracil phosphoribosyltransferase [Nucleotide transport and metabolism]; Region: PyrR; COG2065 637909004471 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 637909004472 active site 637909004473 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 637909004474 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 637909004475 RNA binding surface [nucleotide binding]; other site 637909004476 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 637909004477 active site 637909004478 lipoprotein signal peptidase; Provisional; Region: PRK14797 637909004479 lipoprotein signal peptidase; Provisional; Region: PRK14787 637909004480 Transcriptional regulator [Transcription]; Region: LysR; COG0583 637909004481 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 637909004482 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 637909004483 dimerization interface [polypeptide binding]; other site 637909004484 50S ribosomal protein L27; Validated; Region: rpmA; PRK05435 637909004485 Protein of unknown function (DUF464); Region: DUF464; pfam04327 637909004486 50S ribosomal protein L21; Validated; Region: rplU; PRK05573 637909004487 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 637909004488 Coenzyme A binding pocket [chemical binding]; other site 637909004489 Putative enzyme of poly-gamma-glutamate biosynthesis (capsule formation) [Cell envelope biogenesis, outer membrane]; Region: PgsA; COG2843 637909004490 CapA and related proteins, metallophosphatase domain; Region: MPP_CapA; cd07381 637909004491 putative active site [active] 637909004492 putative metal binding site [ion binding]; other site 637909004493 thiamine biosynthesis protein ThiI; Provisional; Region: PRK01565 637909004494 THUMP domain of thiamine biosynthesis protein ThiI; Region: THUMP_ThiI; cd11716 637909004495 ThiI is required for thiazole synthesis in the thiamine biosynthesis pathway. It belongs to the Adenosine Nucleotide Hydrolysis suoerfamily and predicted to bind to Adenosine nucleotide; Region: ThiI; cd01712 637909004496 Ligand Binding Site [chemical binding]; other site 637909004497 Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104 637909004498 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 637909004499 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 637909004500 catalytic residue [active] 637909004501 folylpolyglutamate synthase/dihydrofolate synthase; Region: folC; TIGR01499 637909004502 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 637909004503 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 637909004504 L-2-hydroxyisocapronate dehydrogenases and some bacterial L-lactate dehydrogenases; Region: HicDH_like; cd05291 637909004505 tetramer (dimer of dimers) interface [polypeptide binding]; other site 637909004506 L-lactate dehydrogenase; Region: L-LDH-NAD; TIGR01771 637909004507 NAD binding site [chemical binding]; other site 637909004508 dimer interface [polypeptide binding]; other site 637909004509 substrate binding site [chemical binding]; other site 637909004510 hypothetical protein; Provisional; Region: PRK13676 637909004511 prephenate dehydrogenase; Validated; Region: PRK06545 637909004512 prephenate dehydrogenase; Validated; Region: PRK08507 637909004513 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 637909004514 Chorismate synthase [Amino acid transport and metabolism]; Region: AroC; COG0082 637909004515 Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304 637909004516 Tetramer interface [polypeptide binding]; other site 637909004517 active site 637909004518 FMN-binding site [chemical binding]; other site 637909004519 Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195 637909004520 Iron-containing alcohol dehydrogenase; Region: Fe-ADH; pfam00465 637909004521 active site 637909004522 dimer interface [polypeptide binding]; other site 637909004523 metal binding site [ion binding]; metal-binding site 637909004524 shikimate 5-dehydrogenase; Reviewed; Region: aroE; PRK00258 637909004525 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 637909004526 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 637909004527 shikimate binding site; other site 637909004528 NAD(P) binding site [chemical binding]; other site 637909004529 3-dehydroquinate dehydratase [Amino acid transport and metabolism]; Region: AroD; COG0710 637909004530 Type I 3-dehydroquinase, (3-dehydroquinate dehydratase or DHQase); Region: DHQase_I; cd00502 637909004531 active site 637909004532 catalytic residue [active] 637909004533 dimer interface [polypeptide binding]; other site 637909004534 Predicted SAM-dependent methyltransferases [General function prediction only]; Region: COG1092 637909004535 Middle domain of the SAM-dependent methyltransferase RlmI and related proteins; Region: RlmI_M_like; cd11572 637909004536 putative RNA binding site [nucleotide binding]; other site 637909004537 Methyltransferase domain; Region: Methyltransf_26; pfam13659 637909004538 Phosphoglycerol transferase and related proteins, alkaline phosphatase superfamily [Cell envelope biogenesis, outer membrane]; Region: MdoB; COG1368 637909004539 Sulfatase; Region: Sulfatase; pfam00884 637909004540 Ribosomal protein L20; Region: Ribosomal_L20; cd07026 637909004541 23S rRNA binding site [nucleotide binding]; other site 637909004542 L21 binding site [polypeptide binding]; other site 637909004543 L13 binding site [polypeptide binding]; other site 637909004544 50S ribosomal protein L35; Reviewed; Region: rpmI; PRK00172 637909004545 translation initiation factor IF-3; Reviewed; Region: infC; PRK00028 637909004546 Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198 637909004547 Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707 637909004548 cytidylate kinase; Provisional; Region: cmk; PRK00023 637909004549 Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020 637909004550 CMP-binding site; other site 637909004551 The sites determining sugar specificity; other site 637909004552 Ferredoxin [Energy production and conversion]; Region: Fer; COG1141 637909004553 peptidase T; Region: peptidase-T; TIGR01882 637909004554 M20 Peptidase T specifically cleaves tripeptides; Region: M20_peptT; cd03892 637909004555 metal binding site [ion binding]; metal-binding site 637909004556 dimer interface [polypeptide binding]; other site 637909004557 GBS Bsp-like repeat; Region: GBS_Bsp-like; pfam08481 637909004558 GBS Bsp-like repeat; Region: GBS_Bsp-like; pfam08481 637909004559 GBS Bsp-like repeat; Region: GBS_Bsp-like; pfam08481 637909004560 GBS Bsp-like repeat; Region: GBS_Bsp-like; pfam08481 637909004561 GBS Bsp-like repeat; Region: GBS_Bsp-like; pfam08481 637909004562 GBS Bsp-like repeat; Region: GBS_Bsp-like; pfam08481 637909004563 Endo-N-acetylmuramidases (muramidases) are lysozymes (also referred to as peptidoglycan hydrolases) that degrade bacterial cell walls by catalyzing the hydrolysis of 1,4-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues; Region: GH25_muramidase; cl10448 637909004564 Glycosyl hydrolases family 25; Region: Glyco_hydro_25; pfam01183 637909004565 active site 637909004566 undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714 637909004567 Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187 637909004568 Ligand binding site; other site 637909004569 Putative Catalytic site; other site 637909004570 DXD motif; other site 637909004571 Glucosyl transferase GtrII; Region: Glucos_trans_II; pfam14264 637909004572 Phosphoglycerol transferase and related proteins, alkaline phosphatase superfamily [Cell envelope biogenesis, outer membrane]; Region: MdoB; COG1368 637909004573 Sulfatase; Region: Sulfatase; pfam00884 637909004574 Rhamnan synthesis protein F; Region: RgpF; pfam05045 637909004575 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 637909004576 active site 637909004577 ABC-type polysaccharide/polyol phosphate transport system, ATPase component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagH; COG1134 637909004578 ATP-binding cassette component of polysaccharide transport system; Region: ABC_KpsT_Wzt; cd03220 637909004579 Walker A/P-loop; other site 637909004580 ATP binding site [chemical binding]; other site 637909004581 Q-loop/lid; other site 637909004582 ABC transporter signature motif; other site 637909004583 Walker B; other site 637909004584 D-loop; other site 637909004585 H-loop/switch region; other site 637909004586 ABC-type polysaccharide/polyol phosphate export systems, permease component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagG; COG1682 637909004587 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 637909004588 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 637909004589 Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_d; cd04196 637909004590 Probable Catalytic site; other site 637909004591 This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_6; cd04955 637909004592 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 637909004593 dTDP-6-deoxy-L-lyxo-4-hexulose reductase and related proteins, extended (e) SDRs; Region: dTDP_HR_like_SDR_e; cd05254 637909004594 RmlD substrate binding domain; Region: RmlD_sub_bind; pfam04321 637909004595 NADP binding site [chemical binding]; other site 637909004596 active site 637909004597 putative substrate binding site [chemical binding]; other site 637909004598 Predicted metal-sulfur cluster biosynthetic enzyme [General function prediction only]; Region: PaaD; COG2151 637909004599 RNA polymerase sigma factor RpoD; Validated; Region: PRK09210 637909004600 Sigma-70 factor, region 1.1; Region: Sigma70_r1_1; pfam03979 637909004601 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 637909004602 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 637909004603 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 637909004604 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 637909004605 DNA binding residues [nucleotide binding] 637909004606 DNA primase, catalytic core; Region: dnaG; TIGR01391 637909004607 CHC2 zinc finger; Region: zf-CHC2; pfam01807 637909004608 DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275 637909004609 TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364 637909004610 active site 637909004611 metal binding site [ion binding]; metal-binding site 637909004612 interdomain interaction site; other site 637909004613 Large-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscL; COG1970 637909004614 large-conductance mechanosensitive channel; Reviewed; Region: mscL; PRK00567 637909004615 30S ribosomal protein S21; Reviewed; Region: rpsU; PRK00270 637909004616 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 637909004617 PGAP1-like protein; Region: PGAP1; pfam07819 637909004618 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243 637909004619 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 637909004620 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_16; cd07263 637909004621 Esterase/lipase [Lipid metabolism]; Region: Aes; COG0657 637909004622 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 637909004623 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 637909004624 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 637909004625 substrate binding pocket [chemical binding]; other site 637909004626 membrane-bound complex binding site; other site 637909004627 hinge residues; other site 637909004628 transaminase; Validated; Region: PRK07324 637909004629 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 637909004630 pyridoxal 5'-phosphate binding site [chemical binding]; other site 637909004631 homodimer interface [polypeptide binding]; other site 637909004632 catalytic residue [active] 637909004633 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 637909004634 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 637909004635 substrate binding pocket [chemical binding]; other site 637909004636 membrane-bound complex binding site; other site 637909004637 hinge residues; other site 637909004638 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 637909004639 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 637909004640 substrate binding pocket [chemical binding]; other site 637909004641 membrane-bound complex binding site; other site 637909004642 hinge residues; other site 637909004643 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 637909004644 glycogen/starch/alpha-glucan phosphorylases; Region: P_ylase; TIGR02093 637909004645 4-alpha-glucanotransferase; Provisional; Region: PRK14508 637909004646 Transcriptional regulators [Transcription]; Region: PurR; COG1609 637909004647 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 637909004648 DNA binding site [nucleotide binding] 637909004649 domain linker motif; other site 637909004650 Ligand-binding domain of uncharacterized transcription regulator ycjW which is a member of the LacI-GalR family repressors; Region: PBP1_ycjW_transcription_regulator_like; cd06294 637909004651 putative dimerization interface [polypeptide binding]; other site 637909004652 putative ligand binding site [chemical binding]; other site 637909004653 Maltose-binding periplasmic proteins/domains [Carbohydrate transport and metabolism]; Region: MalE; COG2182 637909004654 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 637909004655 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 637909004656 dimer interface [polypeptide binding]; other site 637909004657 conserved gate region; other site 637909004658 putative PBP binding loops; other site 637909004659 ABC-ATPase subunit interface; other site 637909004660 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 637909004661 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 637909004662 dimer interface [polypeptide binding]; other site 637909004663 conserved gate region; other site 637909004664 putative PBP binding loops; other site 637909004665 ABC-ATPase subunit interface; other site 637909004666 MutT homolog-1 (MTH1) is a member of the Nudix hydrolase superfamily. MTH1, the mammalian counterpart of MutT, hydrolyzes oxidized purine nucleoside triphosphates, such as 8-oxo-dGTP and 2-hydroxy-ATP, to monophosphates, thereby preventing the...; Region: MTH1; cd03427 637909004667 putative active site [active] 637909004668 nucleotide binding site [chemical binding]; other site 637909004669 nudix motif; other site 637909004670 putative metal binding site [ion binding]; other site 637909004671 excinuclease ABC subunit B; Provisional; Region: PRK05298 637909004672 Myosin and Kinesin motor domain. These ATPases belong to the P-loop NTPase family and provide the driving force in myosin and kinesin mediated processes; Region: Motor_domain; cl00286 637909004673 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 637909004674 ATP-binding site [chemical binding]; other site 637909004675 ATP binding site [chemical binding]; other site 637909004676 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 637909004677 nucleotide binding region [chemical binding]; other site 637909004678 ATP-binding site [chemical binding]; other site 637909004679 Ultra-violet resistance protein B; Region: UvrB; pfam12344 637909004680 UvrB/uvrC motif; Region: UVR; pfam02151 637909004681 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 637909004682 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 637909004683 substrate binding pocket [chemical binding]; other site 637909004684 membrane-bound complex binding site; other site 637909004685 hinge residues; other site 637909004686 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 637909004687 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 637909004688 substrate binding pocket [chemical binding]; other site 637909004689 membrane-bound complex binding site; other site 637909004690 hinge residues; other site 637909004691 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 637909004692 dimer interface [polypeptide binding]; other site 637909004693 conserved gate region; other site 637909004694 putative PBP binding loops; other site 637909004695 ABC-ATPase subunit interface; other site 637909004696 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 637909004697 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 637909004698 Walker A/P-loop; other site 637909004699 ATP binding site [chemical binding]; other site 637909004700 Q-loop/lid; other site 637909004701 ABC transporter signature motif; other site 637909004702 Walker B; other site 637909004703 D-loop; other site 637909004704 H-loop/switch region; other site 637909004705 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 637909004706 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 637909004707 Walker A/P-loop; other site 637909004708 ATP binding site [chemical binding]; other site 637909004709 Q-loop/lid; other site 637909004710 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 637909004711 H-loop/switch region; other site 637909004712 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 637909004713 GTPase CgtA; Reviewed; Region: obgE; PRK12297 637909004714 GTP1/OBG; Region: GTP1_OBG; pfam01018 637909004715 Obg GTPase; Region: Obg; cd01898 637909004716 G1 box; other site 637909004717 GTP/Mg2+ binding site [chemical binding]; other site 637909004718 Switch I region; other site 637909004719 G2 box; other site 637909004720 G3 box; other site 637909004721 Switch II region; other site 637909004722 G4 box; other site 637909004723 G5 box; other site 637909004724 Domain of unknown function (DUF1967); Region: DUF1967; pfam09269 637909004725 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 637909004726 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 637909004727 RNA binding surface [nucleotide binding]; other site 637909004728 Pseudouridine synthase, Escherichia coli RsuA like; Region: PseudoU_synth_RsuA; cd02553 637909004729 active site 637909004730 uracil binding [chemical binding]; other site 637909004731 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 637909004732 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 637909004733 peptide binding site [polypeptide binding]; other site 637909004734 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 637909004735 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 637909004736 peptide binding site [polypeptide binding]; other site 637909004737 MarR family; Region: MarR_2; cl17246 637909004738 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 637909004739 Predicted membrane protein [Function unknown]; Region: COG2364 637909004740 Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792 637909004741 putative transporter; Provisional; Region: PRK11660 637909004742 Sulfate transporter family; Region: Sulfate_transp; pfam00916 637909004743 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 637909004744 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 637909004745 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 637909004746 non-specific DNA binding site [nucleotide binding]; other site 637909004747 salt bridge; other site 637909004748 sequence-specific DNA binding site [nucleotide binding]; other site 637909004749 Putative zinc ribbon domain; Region: Zn_ribbon_2; pfam12674 637909004750 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 637909004751 nucleoside/Zn binding site; other site 637909004752 dimer interface [polypeptide binding]; other site 637909004753 catalytic motif [active] 637909004754 Uncharacterized protein conserved in bacteria (DUF2316); Region: DUF2316; cl01805 637909004755 multidrug efflux pump VmrA; Reviewed; Region: vmrA; PRK09575 637909004756 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Streptococcus aureus MepA; Region: MATE_MepA_like; cd13143 637909004757 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 637909004758 MarR family; Region: MarR_2; pfam12802 637909004759 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 637909004760 Coenzyme A binding pocket [chemical binding]; other site 637909004761 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 637909004762 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 637909004763 CAAX protease self-immunity; Region: Abi; cl00558 637909004764 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 637909004765 Coenzyme A binding pocket [chemical binding]; other site 637909004766 SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase [Translation, ribosomal structure and biogenesis]; Region: TrmA; COG2265 637909004767 Predicted RNA-binding protein, contains TRAM domain [General function prediction only]; Region: COG3269 637909004768 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 637909004769 S-adenosylmethionine binding site [chemical binding]; other site 637909004770 Transcriptional regulator [Transcription]; Region: LytR; COG1316 637909004771 prephenate dehydratase; Provisional; Region: PRK11898 637909004772 Prephenate dehydratase; Region: PDT; pfam00800 637909004773 C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905 637909004774 putative L-Phe binding site [chemical binding]; other site 637909004775 Shikimate kinase [Amino acid transport and metabolism]; Region: AroK; COG0703 637909004776 Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464 637909004777 ADP binding site [chemical binding]; other site 637909004778 magnesium binding site [ion binding]; other site 637909004779 putative shikimate binding site; other site 637909004780 3-phosphoshikimate 1-carboxyvinyltransferase; Provisional; Region: PRK02427 637909004781 EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556 637909004782 hinge; other site 637909004783 active site 637909004784 GTP-binding protein LepA; Provisional; Region: PRK05433 637909004785 LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890 637909004786 G1 box; other site 637909004787 putative GEF interaction site [polypeptide binding]; other site 637909004788 GTP/Mg2+ binding site [chemical binding]; other site 637909004789 Switch I region; other site 637909004790 G2 box; other site 637909004791 G3 box; other site 637909004792 Switch II region; other site 637909004793 G4 box; other site 637909004794 G5 box; other site 637909004795 lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699 637909004796 lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane. LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709 637909004797 GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421 637909004798 Stu0660-like CRISPR/Cas system-associated protein Csn2; Region: Stu0660_Csn2; cd12217 637909004799 tetramer interface [polypeptide binding]; other site 637909004800 putative DNA binding site [nucleotide binding]; other site 637909004801 CRISPR/Cas system-associated protein Cas2; Region: Cas2_I_II_III; cl11442 637909004802 CRISPR/Cas system-associated protein Cas1; Region: Cas1_II; cd09720 637909004803 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cl00083 637909004804 CRISPR-associated protein Cas9/Csn1, subtype II/NMEMI; Region: cas_Csn1; TIGR01865 637909004805 Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413 637909004806 active site 637909004807 multimer interface [polypeptide binding]; other site 637909004808 Uncharacterized protein family (UPF0150); Region: UPF0150; pfam03681 637909004809 YcfA-like protein; Region: YcfA; pfam07927 637909004810 CRISPR/Cas system-associated protein Csn2; Region: Csn2; cd09758 637909004811 CRISPR type II-A/NMEMI-associated protein Csn2; Region: cas_Csn2; TIGR01866 637909004812 tetramer interface [polypeptide binding]; other site 637909004813 putative DNA binding site [nucleotide binding]; other site 637909004814 Ca binding site [ion binding]; other site 637909004815 Ca binding site [ion binding]; other site 637909004816 CRISPR/Cas system-associated protein Cas2; Region: Cas2_I_II_III; cd09638 637909004817 CRISPR/Cas system-associated protein Cas1; Region: Cas1_II; cd09720 637909004818 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cl00083 637909004819 CRISPR/Cas system-associated protein Cas9; Region: Csn1; cd09643 637909004820 Predicted membrane protein [Function unknown]; Region: COG4478 637909004821 HAD-superfamily subfamily IIA hydrolase, TIGR01457; Region: HAD-SF-IIA-hyp2 637909004822 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 637909004823 active site 637909004824 motif I; other site 637909004825 motif II; other site 637909004826 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 637909004827 Hydrolase of X-linked nucleoside diphosphate N terminal; Region: Nudix_N; pfam12535 637909004828 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_14; cd04672 637909004829 nudix motif; other site 637909004830 Acyl-ACP thioesterase; Region: Acyl-ACP_TE; pfam01643 637909004831 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 637909004832 active site 637909004833 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 637909004834 active site 2 [active] 637909004835 active site 1 [active] 637909004836 coproporphyrinogen III oxidase; Provisional; Region: PRK08599 637909004837 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 637909004838 FeS/SAM binding site; other site 637909004839 HemN C-terminal domain; Region: HemN_C; pfam06969 637909004840 phosphoglucosamine mutase; Provisional; Region: glmM; PRK14316 637909004841 GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802 637909004842 active site 637909004843 substrate binding site [chemical binding]; other site 637909004844 metal binding site [ion binding]; metal-binding site 637909004845 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4856 637909004846 YbbR-like protein; Region: YbbR; pfam07949 637909004847 Uncharacterized conserved protein [Function unknown]; Region: COG1624 637909004848 DisA bacterial checkpoint controller nucleotide-binding; Region: DisA_N; pfam02457 637909004849 UDP-N-acetylmuramyl tripeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurE; COG0769 637909004850 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 637909004851 Domain of unknown function (DUF1727); Region: DUF1727; pfam08353 637909004852 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyric Acid Synthase (CobQ); Region: GATase1_CobQ; cd01750 637909004853 catalytic triad [active] 637909004854 enolase; Provisional; Region: eno; PRK00077 637909004855 Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313 637909004856 dimer interface [polypeptide binding]; other site 637909004857 metal binding site [ion binding]; metal-binding site 637909004858 substrate binding pocket [chemical binding]; other site 637909004859 Protein of unknown function (DUF1694); Region: DUF1694; pfam07997 637909004860 Glycerate kinase [Carbohydrate transport and metabolism]; Region: COG1929 637909004861 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cd02883 637909004862 nudix motif; other site 637909004863 YSIRK type signal peptide; Region: YSIRK_signal; pfam04650 637909004864 Family 41 Carbohydrate-Binding Module from pullulanase-like enzymes; Region: CBM41_pullulanase; cd10315 637909004865 carbohydrate binding site [chemical binding]; other site 637909004866 Bacterial pullanase-associated domain; Region: PUD; pfam03714 637909004867 carbohydrate binding site [chemical binding]; other site 637909004868 Alpha amylase catalytic domain found in bacterial cyclomaltodextrinases and related proteins; Region: AmyAc_bac_CMD_like_2; cd11339 637909004869 Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366 637909004870 active site 637909004871 catalytic site [active] 637909004872 pullulanase, extracellular, Gram-positive; Region: pullulan_Gpos; TIGR02102 637909004873 Family 41 Carbohydrate-Binding Module from pullulanase-like enzymes; Region: CBM41_pullulanase; cd10315 637909004874 carbohydrate binding site [chemical binding]; other site 637909004875 Family 41 Carbohydrate-Binding Module from pullulanase-like enzymes; Region: CBM41_pullulanase; cd10315 637909004876 carbohydrate binding site [chemical binding]; other site 637909004877 Early set domain associated with the catalytic domain of pullulanase (also called dextrinase and alpha-dextrin endo-1,6-alpha glucosidase); Region: E_set_Pullulanase; cd02860 637909004878 Alpha amylase catalytic domain found in Pullulanase (also called dextrinase; alpha-dextrin endo-1,6-alpha glucosidase), limit dextrinase, and related proteins; Region: AmyAc_Pullulanase_LD-like; cd11341 637909004879 Ca binding site [ion binding]; other site 637909004880 active site 637909004881 catalytic site [active] 637909004882 LPXTG-motif cell wall anchor domain; Region: LPXTG_anchor; TIGR01167 637909004883 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in Escherichia coli phosphoribosyl-ATP pyrophosphohydrolase (HisIE or PRATP-PH) and its homologs; Region: NTP-PPase_HisIE_like; cd11534 637909004884 metal binding site [ion binding]; metal-binding site 637909004885 phosphoribosyl-AMP cyclohydrolase; Reviewed; Region: hisI; PRK00051 637909004886 The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731 637909004887 Histidine biosynthesis protein; Region: His_biosynth; pfam00977 637909004888 substrate binding site [chemical binding]; other site 637909004889 glutamase interaction surface [polypeptide binding]; other site 637909004890 HisA. Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1...; Region: HisA; cd04732 637909004891 phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; Region: TIGR00007 637909004892 catalytic residues [active] 637909004893 imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13141 637909004894 Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748 637909004895 putative active site [active] 637909004896 oxyanion strand; other site 637909004897 catalytic triad [active] 637909004898 Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cd07914 637909004899 putative active site pocket [active] 637909004900 4-fold oligomerization interface [polypeptide binding]; other site 637909004901 metal binding residues [ion binding]; metal-binding site 637909004902 3-fold/trimer interface [polypeptide binding]; other site 637909004903 phosphoserine phosphatase SerB; Region: serB; TIGR00338 637909004904 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 637909004905 motif II; other site 637909004906 Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572 637909004907 histidinol dehydrogenase; Region: hisD; TIGR00069 637909004908 NAD binding site [chemical binding]; other site 637909004909 dimerization interface [polypeptide binding]; other site 637909004910 product binding site; other site 637909004911 substrate binding site [chemical binding]; other site 637909004912 zinc binding site [ion binding]; other site 637909004913 catalytic residues [active] 637909004914 ATP phosphoribosyltransferase catalytic subunit; Reviewed; Region: hisG; PRK01686 637909004915 ATP phosphoribosyltransferase [Amino acid transport and metabolism]; Region: HisG; COG0040 637909004916 ATP phosphoribosyltransferase, regulatory subunit; Region: hisZ_biosyn_reg; TIGR00443 637909004917 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 637909004918 dimer interface [polypeptide binding]; other site 637909004919 motif 1; other site 637909004920 active site 637909004921 motif 2; other site 637909004922 motif 3; other site 637909004923 Histidinol-phosphate/aromatic aminotransferase and cobyric acid decarboxylase [Amino acid transport and metabolism]; Region: HisC; COG0079 637909004924 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 637909004925 pyridoxal 5'-phosphate binding site [chemical binding]; other site 637909004926 homodimer interface [polypeptide binding]; other site 637909004927 catalytic residue [active] 637909004928 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Provisional; Region: PRK07164 637909004929 Phosphorylase superfamily; Region: PNP_UDP_1; cl00303 637909004930 septation ring formation regulator EzrA; Provisional; Region: PRK04778 637909004931 DNA gyrase subunit B; Validated; Region: gyrB; PRK05644 637909004932 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 637909004933 Mg2+ binding site [ion binding]; other site 637909004934 G-X-G motif; other site 637909004935 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 637909004936 anchoring element; other site 637909004937 dimer interface [polypeptide binding]; other site 637909004938 ATP binding site [chemical binding]; other site 637909004939 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 637909004940 active site 637909004941 putative metal-binding site [ion binding]; other site 637909004942 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 637909004943 haloacid dehalogenase superfamily, subfamily IA, variant 1 with third motif having Dx(3-4)D or Dx(3-4)E; Region: HAD-SF-IA-v1; TIGR01549 637909004944 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 637909004945 motif II; other site 637909004946 Bacterial cell division membrane protein [Cell division and chromosome partitioning]; Region: FtsW; COG0772 637909004947 50S ribosomal protein L19; Provisional; Region: rplS; PRK05338 637909004948 CLC voltage-gated chloride channel. The ClC chloride channels catalyse the selective flow of Cl- ions across cell membranes, thereby regulating electrical excitation in skeletal muscle and the flow of salt and water across epithelial barriers. This...; Region: Voltage_gated_ClC; cl02915 637909004949 Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038 637909004950 Cl- selectivity filter; other site 637909004951 Cl- binding residues [ion binding]; other site 637909004952 pore gating glutamate residue; other site 637909004953 dimer interface [polypeptide binding]; other site 637909004954 hypothetical protein; Provisional; Region: PRK07248 637909004955 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 637909004956 cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814; cl03223 637909004957 FeS assembly protein SufB; Region: sufB; TIGR01980 637909004958 flavodoxin; Validated; Region: PRK07308 637909004959 Adenosine deaminase [Nucleotide transport and metabolism]; Region: Add; COG1816 637909004960 Adenosine deaminase (ADA) is a monomeric zinc dependent enzyme which catalyzes the irreversible hydrolytic deamination of both adenosine, as well as desoxyadenosine, to ammonia and inosine or desoxyinosine, respectively. ADA plays an important role in...; Region: ADA; cd01320 637909004961 active site 637909004962 purine riboside binding site [chemical binding]; other site 637909004963 asparaginyl-tRNA synthetase; Validated; Region: asnC; PRK03932 637909004964 AsnRS_cyto_like_N: N-terminal, anticodon recognition domain of the type found in human and Saccharomyces cerevisiae cytoplasmic asparaginyl-tRNA synthetase (AsnRS), in Brugia malayai AsnRs and, in various putative bacterial AsnRSs. This domain is a...; Region: AsnRS_cyto_like_N; cd04323 637909004965 putative dimer interface [polypeptide binding]; other site 637909004966 putative anticodon binding site; other site 637909004967 Asx tRNA synthetase (AspRS/AsnRS) class II core domain. Assignment to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs in the core domain. This family includes AsnRS as well as...; Region: AsxRS_core; cd00776 637909004968 homodimer interface [polypeptide binding]; other site 637909004969 motif 1; other site 637909004970 motif 2; other site 637909004971 active site 637909004972 motif 3; other site 637909004973 Chagasin family peptidase inhibitor I42; Region: Inhibitor_I42; pfam09394 637909004974 aspartate aminotransferase; Provisional; Region: PRK05764 637909004975 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 637909004976 pyridoxal 5'-phosphate binding site [chemical binding]; other site 637909004977 homodimer interface [polypeptide binding]; other site 637909004978 catalytic residue [active] 637909004979 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5353 637909004980 bifunctional ATP-dependent DNA helicase/DNA polymerase III subunit epsilon; Validated; Region: PRK07246 637909004981 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 637909004982 active site 637909004983 catalytic site [active] 637909004984 substrate binding site [chemical binding]; other site 637909004985 CRISPR/Cas system-associated DinG family helicase Csf4; Region: Csf4_U; cl17460 637909004986 Helicase C-terminal domain; Region: Helicase_C_2; pfam13307 637909004987 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819 637909004988 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4947 637909004989 Putative esterase; Region: Esterase; pfam00756 637909004990 ATP-grasp domain; Region: ATP-grasp_4; pfam13535 637909004991 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 637909004992 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 637909004993 Cell division protein [Cell division and chromosome partitioning]; Region: FtsX; COG2177 637909004994 cell division ABC transporter subunit FtsX; Provisional; Region: ftsX; PRK11026 637909004995 Predicted ATPase involved in cell division [Cell division and chromosome partitioning]; Region: FtsE; COG2884 637909004996 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 637909004997 Walker A/P-loop; other site 637909004998 ATP binding site [chemical binding]; other site 637909004999 Q-loop/lid; other site 637909005000 ABC transporter signature motif; other site 637909005001 Walker B; other site 637909005002 D-loop; other site 637909005003 H-loop/switch region; other site 637909005004 peptide chain release factor 2; Validated; Region: prfB; PRK00578 637909005005 PCRF domain; Region: PCRF; pfam03462 637909005006 RF-1 domain; Region: RF-1; pfam00472 637909005007 Predicted phosphatase/phosphohexomutase [General function prediction only]; Region: COG0637 637909005008 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 637909005009 motif II; other site 637909005010 putative phosphoesterase; Region: acc_ester; TIGR03729 637909005011 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 637909005012 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 637909005013 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; pfam00690 637909005014 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 637909005015 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 637909005016 haloacid dehalogenase-like hydrolase; Region: HAD; pfam12710 637909005017 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 637909005018 Domain of unknown function (DUF1934); Region: DUF1934; pfam09148 637909005019 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 637909005020 HD superfamily phosphohydrolases [General function prediction only]; Region: COG1078 637909005021 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 637909005022 Zn2+ binding site [ion binding]; other site 637909005023 Mg2+ binding site [ion binding]; other site 637909005024 sugar phosphate phosphatase; Provisional; Region: PRK10513 637909005025 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 637909005026 active site 637909005027 motif I; other site 637909005028 motif II; other site 637909005029 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 637909005030 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 637909005031 FemAB family; Region: FemAB; pfam02388 637909005032 FemAB family; Region: FemAB; pfam02388 637909005033 U3 small nucleolar ribonucleoprotein component [Translation, ribosomal structure and biogenesis]; Region: Mpp10; COG5384 637909005034 Acetyltransferase (GNAT) domain; Region: Acetyltransf_6; pfam13480 637909005035 triosephosphate isomerase; Provisional; Region: PRK14567 637909005036 Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311 637909005037 substrate binding site [chemical binding]; other site 637909005038 dimer interface [polypeptide binding]; other site 637909005039 catalytic triad [active] 637909005040 elongation factor Tu; Reviewed; Region: PRK00049 637909005041 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 637909005042 G1 box; other site 637909005043 GEF interaction site [polypeptide binding]; other site 637909005044 GTP/Mg2+ binding site [chemical binding]; other site 637909005045 Switch I region; other site 637909005046 G2 box; other site 637909005047 G3 box; other site 637909005048 Switch II region; other site 637909005049 G4 box; other site 637909005050 G5 box; other site 637909005051 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 637909005052 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 637909005053 Antibiotic Binding Site [chemical binding]; other site 637909005054 Sigma factor regulator N-terminal; Region: Sigma_reg_N; pfam13800 637909005055 Sigma factor regulator C-terminal; Region: Sigma_reg_C; pfam13791 637909005056 RNA polymerase sigma factor, SigM family; Region: SigM_subfam; TIGR02950 637909005057 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 637909005058 DNA binding residues [nucleotide binding] 637909005059 Bacterial cell division membrane protein [Cell division and chromosome partitioning]; Region: FtsW; COG0772 637909005060 phosphoenolpyruvate carboxylase; Reviewed; Region: PRK00009 637909005061 Phosphoenolpyruvate carboxylase [Energy production and conversion]; Region: Ppc; COG2352 637909005062 oligoendopeptidase F; Region: pepF; TIGR00181 637909005063 Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins); Region: GluZincin; cl14813 637909005064 Zn binding site [ion binding]; other site 637909005065 Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per...; Region: GSH_Peroxidase; cd00340 637909005066 catalytic residues [active] 637909005067 dimer interface [polypeptide binding]; other site 637909005068 Lyzozyme M1 (1,4-beta-N-acetylmuramidase) [Cell envelope biogenesis, outer membrane]; Region: Acm; COG3757 637909005069 PlyB is a bacteriophage endolysin that displays potent lytic activity toward Bacillus anthracis. PlyB has an N-terminal glycosyl hydrolase family 25 (GH25) catalytic domain and a C-terminal bacterial SH3-like domain, SH3b. Both domains are required for...; Region: GH25_PlyB-like; cd06523 637909005070 active site 637909005071 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 637909005072 amidase catalytic site [active] 637909005073 Zn binding residues [ion binding]; other site 637909005074 substrate binding site [chemical binding]; other site 637909005075 This CD includes cysteinyl-tRNA(Pro) deacylases from Haemophilus influenzae and Escherichia coli and other related bacterial proteins. These trans-acting, single-domain proteins are homologs of ProX and also the cis-acting prolyl-tRNA synthetase (ProRS)...; Region: YbaK_deacylase; cd00002 637909005076 putative deacylase active site [active] 637909005077 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 637909005078 catalytic core [active] 637909005079 Predicted hydrolase (HAD superfamily) [General function prediction only]; Region: COG1011 637909005080 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 637909005081 motif II; other site 637909005082 lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484 637909005083 LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322 637909005084 dimer interface [polypeptide binding]; other site 637909005085 putative anticodon binding site; other site 637909005086 Lys_tRNA synthetase (LysRS) class II core domain. Class II LysRS is a dimer which attaches a lysine to the 3' OH group of ribose of the appropriate tRNA. Its assignment to class II aaRS is based upon its structure and the presence of three...; Region: LysRS_core; cd00775 637909005087 motif 1; other site 637909005088 active site 637909005089 motif 2; other site 637909005090 motif 3; other site 637909005091 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 637909005092 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 637909005093 Transcriptional regulator C-terminal region; Region: TetR_C_8; pfam14278 637909005094 Predicted hydrolase (HAD superfamily) [General function prediction only]; Region: COG1011 637909005095 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 637909005096 active site 637909005097 motif I; other site 637909005098 motif II; other site 637909005099 BioY family; Region: BioY; pfam02632 637909005100 Uncharacterized protein conserved in bacteria (DUF2128); Region: DUF2128; pfam09901 637909005101 Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826 637909005102 Peptidase family U32; Region: Peptidase_U32; pfam01136 637909005103 Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826 637909005104 Phosphoribosyltransferase (PRTase) type II; This family contains two enzymes that play an important role in NAD production by either allowing quinolinic acid (QA) , quinolinate phosphoribosyl transferase (QAPRTase), or nicotinic acid (NA), nicotinate...; Region: PRTase_typeII; cl17275 637909005105 Peptidase family U32; Region: Peptidase_U32; pfam01136 637909005106 Protein of unknown function (DUF3270); Region: DUF3270; pfam11674 637909005107 Uncharacterized protein containing a divergent version of the methyl-accepting chemotaxis-like domain [General function prediction only]; Region: COG4768 637909005108 Prolipoprotein diacylglyceryl transferase; Region: LGT; pfam01790 637909005109 HPr kinase/phosphorylase; Provisional; Region: PRK05428 637909005110 HPr Serine kinase N terminus; Region: Hpr_kinase_N; pfam02603 637909005111 HprK/P, the bifunctional histidine-containing protein kinase/phosphatase, controls the phosphorylation state of the phosphocarrier protein HPr and regulates the utilization of carbon sources by gram-positive bacteria. It catalyzes both the ATP-dependent...; Region: HprK_C; cd01918 637909005112 Hpr binding site; other site 637909005113 active site 637909005114 homohexamer subunit interaction site [polypeptide binding]; other site 637909005115 PspC domain; Region: PspC; pfam04024 637909005116 hypothetical protein; Provisional; Region: PRK04351 637909005117 Zn-dependent metalloprotease, SprT family [General function prediction only]; Region: SprT; COG3091 637909005118 Transcriptional accessory protein [Transcription]; Region: Tex; COG2183 637909005119 Tex-like protein N-terminal domain; Region: Tex_N; pfam09371 637909005120 Likely ribonuclease with RNase H fold; Region: YqgFc; smart00732 637909005121 S1_Tex: The C-terminal S1 domain of a transcription accessory factor called Tex, which has been characterized in Bordetella pertussis and Pseudomonas aeruginosa. The tex gene is essential in Bortella pertusis and is named for its role in toxin expression; Region: S1_Tex; cd05685 637909005122 RNA binding site [nucleotide binding]; other site 637909005123 Predicted permeases [General function prediction only]; Region: COG0701 637909005124 Predicted membrane protein [Function unknown]; Region: COG3689 637909005125 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 637909005126 Medium chain dehydrogenases/reductase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR2; cd08268 637909005127 putative NAD(P) binding site [chemical binding]; other site 637909005128 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 637909005129 Helix-Turn-Helix DNA binding domain of the MerR-like transcription regulators YyaN and YraB; Region: HTH_YyaN; cd01109 637909005130 DNA binding residues [nucleotide binding] 637909005131 putative dimer interface [polypeptide binding]; other site 637909005132 signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416 637909005133 SRP54-type protein, helical bundle domain; Region: SRP54_N; pfam02881 637909005134 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 637909005135 P loop; other site 637909005136 GTP binding site [chemical binding]; other site 637909005137 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 637909005138 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 637909005139 active site 637909005140 motif I; other site 637909005141 motif II; other site 637909005142 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 637909005143 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cl17915 637909005144 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 637909005145 active site 637909005146 motif I; other site 637909005147 motif II; other site 637909005148 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 637909005149 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 637909005150 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 637909005151 Walker A/P-loop; other site 637909005152 ATP binding site [chemical binding]; other site 637909005153 Q-loop/lid; other site 637909005154 SMC proteins Flexible Hinge Domain; Region: SMC_hinge; smart00968 637909005155 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 637909005156 ABC transporter signature motif; other site 637909005157 Walker B; other site 637909005158 D-loop; other site 637909005159 H-loop/switch region; other site 637909005160 ribonuclease III; Reviewed; Region: rnc; PRK00102 637909005161 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 637909005162 dimerization interface [polypeptide binding]; other site 637909005163 active site 637909005164 metal binding site [ion binding]; metal-binding site 637909005165 Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048 637909005166 dsRNA binding site [nucleotide binding]; other site 637909005167 Metal-dependent hydrolases of the beta-lactamase superfamily I [General function prediction only]; Region: PhnP; COG1235 637909005168 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 637909005169 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: VicK; COG5002 637909005170 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 637909005171 putative active site [active] 637909005172 heme pocket [chemical binding]; other site 637909005173 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 637909005174 dimer interface [polypeptide binding]; other site 637909005175 phosphorylation site [posttranslational modification] 637909005176 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 637909005177 ATP binding site [chemical binding]; other site 637909005178 Mg2+ binding site [ion binding]; other site 637909005179 G-X-G motif; other site 637909005180 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 637909005181 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 637909005182 active site 637909005183 phosphorylation site [posttranslational modification] 637909005184 intermolecular recognition site; other site 637909005185 dimerization interface [polypeptide binding]; other site 637909005186 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 637909005187 DNA binding site [nucleotide binding] 637909005188 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 637909005189 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 637909005190 Walker A/P-loop; other site 637909005191 ATP binding site [chemical binding]; other site 637909005192 Q-loop/lid; other site 637909005193 ABC transporter signature motif; other site 637909005194 Walker B; other site 637909005195 D-loop; other site 637909005196 H-loop/switch region; other site 637909005197 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 637909005198 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 637909005199 substrate binding pocket [chemical binding]; other site 637909005200 membrane-bound complex binding site; other site 637909005201 hinge residues; other site 637909005202 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 637909005203 dimer interface [polypeptide binding]; other site 637909005204 conserved gate region; other site 637909005205 putative PBP binding loops; other site 637909005206 ABC-ATPase subunit interface; other site 637909005207 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 637909005208 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 637909005209 dimer interface [polypeptide binding]; other site 637909005210 conserved gate region; other site 637909005211 putative PBP binding loops; other site 637909005212 ABC-ATPase subunit interface; other site 637909005213 Uncharacterized conserved protein [Function unknown]; Region: COG0398 637909005214 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 637909005215 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 637909005216 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 637909005217 dimer interface [polypeptide binding]; other site 637909005218 phosphorylation site [posttranslational modification] 637909005219 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 637909005220 ATP binding site [chemical binding]; other site 637909005221 Mg2+ binding site [ion binding]; other site 637909005222 G-X-G motif; other site 637909005223 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 637909005224 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 637909005225 active site 637909005226 phosphorylation site [posttranslational modification] 637909005227 intermolecular recognition site; other site 637909005228 dimerization interface [polypeptide binding]; other site 637909005229 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 637909005230 DNA binding site [nucleotide binding] 637909005231 Protein of unknown function (DUF3114); Region: DUF3114; pfam11311 637909005232 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3041 637909005233 RelB antitoxin; Region: RelB; cl01171 637909005234 probable dihydroxyacetone kinase regulator; Region: DHAK_reg; TIGR02366 637909005235 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 637909005236 myosin-cross-reactive antigen; Provisional; Region: PRK13977 637909005237 Sortase C (SrtC) or subfamily-3 sortases are membrane cysteine transpeptidases found in Gram-positive bacteria that anchor surface proteins to peptidoglycans of the bacterial cell wall envelope. This involves a transpeptidation reaction in which the...; Region: Sortase_C_3; cd05827 637909005238 active site 637909005239 catalytic site [active] 637909005240 fimbrial isopeptide formation D2 domain; Region: RrgB_K2N_iso_D2; TIGR04226 637909005241 Cna protein B-type domain; Region: Cna_B; pfam05738 637909005242 TQXA domain; Region: TQXA_dom; TIGR03934 637909005243 Repeat unit of collagen-binding protein domain B; Region: CollagenBindB; cd00222 637909005244 domain interaction interfaces [polypeptide binding]; other site 637909005245 Repeat unit of collagen-binding protein domain B; Region: CollagenBindB; cd00222 637909005246 domain interaction interfaces [polypeptide binding]; other site 637909005247 Repeat unit of collagen-binding protein domain B; Region: CollagenBindB; cd00222 637909005248 domain interaction interfaces [polypeptide binding]; other site 637909005249 Repeat unit of collagen-binding protein domain B; Region: CollagenBindB; cd00222 637909005250 domain interaction interfaces [polypeptide binding]; other site 637909005251 LPXTG-motif cell wall anchor domain; Region: LPXTG_anchor; TIGR01167 637909005252 LXG domain of WXG superfamily; Region: LXG; pfam04740 637909005253 type VII secretion effector, SACOL2603 family; Region: T7SS_SACOL2603; TIGR04197 637909005254 Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific...; Region: RICIN; cd00161 637909005255 Ricin-type beta-trefoil lectin domain; Region: Ricin_B_lectin; pfam00652 637909005256 putative sugar binding sites [chemical binding]; other site 637909005257 Q-X-W motif; other site 637909005258 threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK00413 637909005259 TGS _ThrRS_N: ThrRS (threonyl-tRNA Synthetase) is a class II tRNA synthetase that couples threonine to its cognate tRNA. In addition to its catalytic and anticodon-binding domains, ThrRS has an N-terminal TGS domain, named after the ThrRS, GTPase, and...; Region: TGS_ThrRS_N; cd01667 637909005260 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 637909005261 Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771 637909005262 active site 637909005263 dimer interface [polypeptide binding]; other site 637909005264 motif 1; other site 637909005265 motif 2; other site 637909005266 motif 3; other site 637909005267 ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860 637909005268 anticodon binding site; other site 637909005269 This family is most closely related to the GT1 family of glycosyltransferases. UDP-glucose-diacylglycerol glucosyltransferase (UGDG; also known as 1,2-diacylglycerol 3-glucosyltransferase) catalyzes the transfer of glucose from UDP-glucose to 1; Region: GT1_UGDG_like; cd03817 637909005270 Glycosyltransferase Family 4; Region: Glyco_transf_4; pfam13439 637909005271 putative ADP-binding pocket [chemical binding]; other site 637909005272 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 637909005273 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 637909005274 catabolite control protein A; Region: ccpA; TIGR01481 637909005275 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 637909005276 DNA binding site [nucleotide binding] 637909005277 domain linker motif; other site 637909005278 Ligand-binding domain of the catabolite control protein A (CcpA), which functions as the major transcriptional regulator of carbon catabolite repression/regulation; Region: PBP1_CcpA_like; cd06298 637909005279 dimerization interface [polypeptide binding]; other site 637909005280 effector binding site; other site 637909005281 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 637909005282 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 637909005283 Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092 637909005284 active site 637909005285 Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism]; Region: EmrE; COG2076 637909005286 NADH pyrophosphatase, a member of the Nudix hydrolase superfamily, catalyzes the cleavage of NADH into reduced nicotinamide mononucleotide (NMNH) and AMP. Like other members of the Nudix family, it requires a divalent cation, such as Mg2+ or Mn2+, for...; Region: NADH_pyrophosphatase; cd03429 637909005287 putative NADH binding site [chemical binding]; other site 637909005288 putative active site [active] 637909005289 nudix motif; other site 637909005290 putative metal binding site [ion binding]; other site 637909005291 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 637909005292 Sel1-like repeats; Region: SEL1; smart00671 637909005293 LPXTG-motif cell wall anchor domain; Region: LPXTG_anchor; TIGR01167 637909005294 PTS system, beta-glucoside-specific IIABC component; Region: PTS-II-ABC-beta; TIGR01995 637909005295 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 637909005296 active site turn [active] 637909005297 phosphorylation site [posttranslational modification] 637909005298 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 637909005299 Phosphotransferase system IIA components [Carbohydrate transport and metabolism]; Region: NagE; COG2190 637909005300 HPr interaction site; other site 637909005301 glycerol kinase (GK) interaction site [polypeptide binding]; other site 637909005302 active site 637909005303 phosphorylation site [posttranslational modification] 637909005304 Neutral/alkaline non-lysosomal ceramidase; Region: Ceramidase_alk; cl04712 637909005305 Neutral/alkaline non-lysosomal ceramidase; Region: Ceramidase_alk; cl04712 637909005306 Amidohydrolase; Region: Amidohydro_2; pfam04909 637909005307 Transcriptional regulator [Transcription]; Region: LysR; COG0583 637909005308 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 637909005309 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 637909005310 dimerization interface [polypeptide binding]; other site 637909005311 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Bacillus subtilis yoeA; Region: MATE_yoeA_like; cd13138 637909005312 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 637909005313 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028 637909005314 classical (c) SDRs; Region: SDR_c; cd05233 637909005315 NAD(P) binding site [chemical binding]; other site 637909005316 active site 637909005317 beta-phosphoglucomutase; Region: bPGM; TIGR01990 637909005318 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 637909005319 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 637909005320 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; cl07971 637909005321 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 637909005322 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; cl07971 637909005323 Poly(3-hydroxybutyrate) depolymerase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: LpqC; COG3509 637909005324 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 637909005325 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 637909005326 active site 637909005327 catalytic tetrad [active] 637909005328 MFS/sugar transport protein; Region: MFS_2; pfam13347 637909005329 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 637909005330 Amidohydrolase; Region: Amidohydro_2; pfam04909 637909005331 uncharacterized YdjC-like family proteins from bacteria; Region: YdjC_like_1; cd10805 637909005332 putative active site [active] 637909005333 YdjC motif; other site 637909005334 Mg binding site [ion binding]; other site 637909005335 putative homodimer interface [polypeptide binding]; other site 637909005336 PTS system, sucrose-specific IIBC component; Region: PTS-II-BC-sucr; TIGR01996 637909005337 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 637909005338 active site turn [active] 637909005339 phosphorylation site [posttranslational modification] 637909005340 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 637909005341 transcriptional antiterminator BglG; Provisional; Region: PRK09772 637909005342 CAT RNA binding domain; Region: CAT_RBD; smart01061 637909005343 PRD domain; Region: PRD; pfam00874 637909005344 PRD domain; Region: PRD; pfam00874 637909005345 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 637909005346 Sel1-like repeats; Region: SEL1; smart00671 637909005347 PTS system, sucrose-specific IIBC component; Region: PTS-II-BC-sucr; TIGR01996 637909005348 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 637909005349 active site turn [active] 637909005350 phosphorylation site [posttranslational modification] 637909005351 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 637909005352 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 637909005353 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 637909005354 SIS domain. SIS (Sugar ISomerase) domains are found in many phosphosugar isomerases and phosphosugar binding proteins. SIS domains are also found in proteins that regulate the expression of genes involved in synthesis of phosphosugars; Region: SIS; cl00389 637909005355 3-polyprenyl-4-hydroxybenzoate decarboxylase [Coenzyme metabolism]; Region: UbiX; COG0163 637909005356 Flavoprotein; Region: Flavoprotein; pfam02441 637909005357 3-octaprenyl-4-hydroxybenzoate carboxy-lyase; Region: UbiD; pfam01977 637909005358 Transcriptional regulator [Transcription]; Region: LysR; COG0583 637909005359 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 637909005360 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 637909005361 dimerization interface [polypeptide binding]; other site 637909005362 Protein of unknown function (DUF554); Region: DUF554; pfam04474 637909005363 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 637909005364 MarR family; Region: MarR_2; pfam12802 637909005365 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 637909005366 hydrophobic ligand binding site; other site 637909005367 NAD(P)H:FMN oxidoreductase family. This domain catalyzes the reduction of flavin, nitrocompound, quinones and azo compounds using NADH or NADPH as an electron donor. The enzyme is a homodimer, and each monomer binds a FMN as co-factor. This family...; Region: NfsB_like_nitroreductase; cd02149 637909005368 dimer interface [polypeptide binding]; other site 637909005369 FMN binding site [chemical binding]; other site 637909005370 Glycosyl hydrolase family 1; Region: Glyco_hydro_1; cl01046 637909005371 beta-galactosidase; Region: BGL; TIGR03356 637909005372 PTS system, beta-glucoside-specific IIABC component; Region: PTS-II-ABC-beta; TIGR01995 637909005373 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 637909005374 active site turn [active] 637909005375 phosphorylation site [posttranslational modification] 637909005376 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 637909005377 Phosphotransferase system IIA components [Carbohydrate transport and metabolism]; Region: NagE; COG2190 637909005378 HPr interaction site; other site 637909005379 glycerol kinase (GK) interaction site [polypeptide binding]; other site 637909005380 active site 637909005381 phosphorylation site [posttranslational modification] 637909005382 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 637909005383 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 637909005384 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 637909005385 putative active site [active] 637909005386 Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294 637909005387 SmpB-tmRNA interface; other site 637909005388 ribonuclease R; Region: RNase_R; TIGR02063 637909005389 Ribonuclease B OB domain; Region: OB_RNB; pfam08206 637909005390 RNB domain; Region: RNB; pfam00773 637909005391 S1_RNase_R: RNase R C-terminal S1 domain. RNase R is a processive 3' to 5' exoribonuclease, which is a homolog of RNase II. RNase R degrades RNA with secondary structure having a 3' overhang of at least 7 nucleotides. RNase R and PNPase...; Region: S1_RNase_R; cd04471 637909005392 RNA binding site [nucleotide binding]; other site 637909005393 preprotein translocase subunit SecG; Reviewed; Region: secG; PRK06870 637909005394 50S ribosomal protein L33; Validated; Region: rpmG; PRK00595 637909005395 drug efflux system protein MdtG; Provisional; Region: PRK09874 637909005396 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 637909005397 putative substrate translocation pore; other site 637909005398 Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022 637909005399 Dephospho-CoA kinase [Coenzyme metabolism]; Region: CoaE; COG0237 637909005400 CoA-binding site [chemical binding]; other site 637909005401 formamidopyrimidine/5-formyluracil/ 5-hydroxymethyluracil DNA glycosylase; Validated; Region: PRK01103 637909005402 N-terminal domain of Escherichia coli Fpg1/MutM and related bacterial DNA glycosylases; Region: EcFpg-like_N; cd08966 637909005403 DNA binding site [nucleotide binding] 637909005404 catalytic residue [active] 637909005405 H2TH interface [polypeptide binding]; other site 637909005406 putative catalytic residues [active] 637909005407 turnover-facilitating residue; other site 637909005408 intercalation triad [nucleotide binding]; other site 637909005409 8OG recognition residue [nucleotide binding]; other site 637909005410 putative reading head residues; other site 637909005411 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 637909005412 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 637909005413 GTPase Era; Reviewed; Region: era; PRK00089 637909005414 E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163 637909005415 G1 box; other site 637909005416 GTP/Mg2+ binding site [chemical binding]; other site 637909005417 Switch I region; other site 637909005418 G2 box; other site 637909005419 Switch II region; other site 637909005420 G3 box; other site 637909005421 G4 box; other site 637909005422 G5 box; other site 637909005423 KH domain; Region: KH_2; pfam07650 637909005424 Diacylglycerol kinase [Cell envelope biogenesis, outer membrane]; Region: DgkA; COG0818 637909005425 metal-binding heat shock protein; Provisional; Region: PRK00016 637909005426 Alpha amylase catalytic domain found in bacterial Alpha-amylases (also called 1,4-alpha-D-glucan-4-glucanohydrolase); Region: AmyAc_bac1_AmyA; cd11315 637909005427 Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366 637909005428 active site 637909005429 Ca binding site [ion binding]; other site 637909005430 catalytic site [active] 637909005431 Aamy_C domain; Region: Aamy_C; smart00632 637909005432 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 637909005433 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 637909005434 Protein of unknown function (DUF3810); Region: DUF3810; pfam12725 637909005435 Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702 637909005436 PhoH-like protein; Region: PhoH; pfam02562 637909005437 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 637909005438 Major Facilitator Superfamily; Region: MFS_1; pfam07690 637909005439 putative substrate translocation pore; other site 637909005440 hypothetical protein; Provisional; Region: PRK13672 637909005441 methionine sulfoxide reductase A; Provisional; Region: PRK14054 637909005442 Predicted RNA-bindining protein (contains S1 and HTH domains) [General function prediction only]; Region: COG2996 637909005443 S1 domain; Region: S1_2; pfam13509 637909005444 Ribosomal protein S1-like RNA-binding domain; Region: S1; smart00316 637909005445 ribosome recycling factor; Reviewed; Region: frr; PRK00083 637909005446 Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation. Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520 637909005447 hinge region; other site 637909005448 UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254 637909005449 putative nucleotide binding site [chemical binding]; other site 637909005450 uridine monophosphate binding site [chemical binding]; other site 637909005451 homohexameric interface [polypeptide binding]; other site 637909005452 Ribosomal protein L1. The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA. In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403 637909005453 mRNA/rRNA interface [nucleotide binding]; other site 637909005454 50S ribosomal protein L11; Validated; Region: rplK; PRK00140 637909005455 Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349 637909005456 23S rRNA interface [nucleotide binding]; other site 637909005457 L7/L12 interface [polypeptide binding]; other site 637909005458 putative thiostrepton binding site; other site 637909005459 L25 interface [polypeptide binding]; other site 637909005460 Protein of unknown function (DUF3397); Region: DUF3397; pfam11877 637909005461 DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674 637909005462 4-hydroxybenzoate polyprenyltransferase and related prenyltransferases [Coenzyme metabolism]; Region: UbiA; cl00337 637909005463 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 637909005464 Ftsk gamma domain; Region: Ftsk_gamma; pfam09397 637909005465 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 637909005466 active site 637909005467 DNA binding site [nucleotide binding] 637909005468 Int/Topo IB signature motif; other site 637909005469 Sortase A (SrtA) or subfamily-1 sortases are cysteine transpeptidases found in gram-positive bacteria that anchor surface proteins to peptidoglycans of the bacterial cell wall envelope. They do so by catalyzing a transpeptidation reaction in which the...; Region: Sortase_A_1; cd06165 637909005470 active site 637909005471 catalytic site [active] 637909005472 CHAP domain; Region: CHAP; pfam05257 637909005473 AAA ATPase containing von Willebrand factor type A (vWA) domain [General function prediction only]; Region: MDN1; COG5271 637909005474 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 637909005475 AAA-like domain; Region: AAA_10; pfam12846 637909005476 TcpE family; Region: TcpE; pfam12648 637909005477 Conjugative transposon protein TcpC; Region: TpcC; pfam12642 637909005478 Antirestriction protein (ArdA); Region: ArdA; cl01953 637909005479 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 637909005480 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 637909005481 non-specific DNA binding site [nucleotide binding]; other site 637909005482 salt bridge; other site 637909005483 sequence-specific DNA binding site [nucleotide binding]; other site 637909005484 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 637909005485 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 637909005486 non-specific DNA binding site [nucleotide binding]; other site 637909005487 salt bridge; other site 637909005488 sequence-specific DNA binding site [nucleotide binding]; other site 637909005489 Replication initiation factor; Region: Rep_trans; pfam02486 637909005490 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 637909005491 putative cross-wall-targeting lipoprotein signal; Region: strep_RK_lipo; TIGR03726 637909005492 LPXTG-motif cell wall anchor domain; Region: LPXTG_anchor; TIGR01167 637909005493 DNA binding domain of tn916 integrase; Region: Integrase_DNA; pfam02920 637909005494 Tn1545-related conjugative transposon integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes bacterial (gram positive) and phage integrases, including those similar to Tn1545, Tn5252, and...; Region: INT_Tn1545_C; cd01199 637909005495 Int/Topo IB signature motif; other site 637909005496 Excisionase from transposon Tn916; Region: Tn916-Xis; pfam09035 637909005497 Helix-turn-helix domain; Region: HTH_16; pfam12645 637909005498 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 637909005499 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 637909005500 DNA binding residues [nucleotide binding] 637909005501 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 637909005502 non-specific DNA binding site [nucleotide binding]; other site 637909005503 salt bridge; other site 637909005504 sequence-specific DNA binding site [nucleotide binding]; other site 637909005505 Cysteine-rich KTR; Region: Cys_rich_KTR; pfam14205 637909005506 Transposase; Region: DEDD_Tnp_IS110; pfam01548 637909005507 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 637909005508 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 637909005509 Plasmid rolling circle replication initiator protein and truncated derivatives [DNA replication, recombination, and repair]; Region: COG5655 637909005510 Plasmid rolling circle replication initiator protein and truncated derivatives [DNA replication, recombination, and repair]; Region: COG5655 637909005511 Plasmid recombination enzyme; Region: Mob_Pre; pfam01076 637909005512 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 637909005513 Major Facilitator Superfamily; Region: MFS_1; pfam07690 637909005514 putative substrate translocation pore; other site 637909005515 Translation elongation factors (GTPases) [Translation, ribosomal structure and biogenesis]; Region: FusA; COG0480 637909005516 Tet(M)-like family includes Tet(M), Tet(O), Tet(W), and OtrA, containing tetracycline resistant proteins; Region: TetM_like; cd04168 637909005517 G1 box; other site 637909005518 putative GEF interaction site [polypeptide binding]; other site 637909005519 GTP/Mg2+ binding site [chemical binding]; other site 637909005520 Switch I region; other site 637909005521 G2 box; other site 637909005522 G3 box; other site 637909005523 Switch II region; other site 637909005524 G4 box; other site 637909005525 G5 box; other site 637909005526 Tet_II: This subfamily represents domain II of ribosomal protection proteins Tet(M) and Tet(O). This domain has homology to domain II of the elongation factors EF-G and EF-2. Tet(M) and Tet(O) catalyze the release of tetracycline (Tc) from the ribosome...; Region: Tet_II; cd03690 637909005527 EF-G_domain IV_RPP domain is a part of bacterial ribosomal protected proteins (RPP) family. RPPs such as tetracycline resistance proteins Tet(M) and Tet(O) mediate tetracycline resistance in both gram-positive and -negative species. Tetracyclines inhibit...; Region: Tet_like_IV; cd01684 637909005528 Tet_C: C-terminus of ribosomal protection proteins Tet(M) and Tet(O). This domain has homology to the C terminal domains of the elongation factors EF-G and EF-2. Tet(M) and Tet(O) catalyze the release of tetracycline (Tc) from the ribosome in a...; Region: Tet_C; cd03711 637909005529 tetracycline resistance determinant leader peptide; Provisional; Region: PRK14751 637909005530 Conjugative transposon protein TcpC; Region: TpcC; pfam12642 637909005531 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 637909005532 N-acetyl-D-glucosamine binding site [chemical binding]; other site 637909005533 catalytic residue [active] 637909005534 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 637909005535 NlpC/P60 family; Region: NLPC_P60; pfam00877 637909005536 ABC-2 family transporter protein; Region: ABC2_membrane_5; pfam13346 637909005537 Haemolysin-III related; Region: HlyIII; cl03831 637909005538 AAA-like domain; Region: AAA_10; pfam12846 637909005539 TcpE family; Region: TcpE; pfam12648 637909005540 Antirestriction protein (ArdA); Region: ArdA; pfam07275 637909005541 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 637909005542 non-specific DNA binding site [nucleotide binding]; other site 637909005543 salt bridge; other site 637909005544 sequence-specific DNA binding site [nucleotide binding]; other site 637909005545 Replication initiation factor; Region: Rep_trans; pfam02486 637909005546 DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674 637909005547 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 637909005548 Walker A motif; other site 637909005549 ATP binding site [chemical binding]; other site 637909005550 Walker B motif; other site 637909005551 arginine finger; other site 637909005552 Bacterial protein of unknown function (DUF961); Region: DUF961; pfam06125 637909005553 Bacterial protein of unknown function (DUF961); Region: DUF961; pfam06125 637909005554 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 637909005555 catalytic residues [active] 637909005556 M14 family of metallocarboxypeptidases and related proteins; Region: Peptidase_M14_like; cl11393 637909005557 Protein of unknown function DUF86; Region: DUF86; cl01031 637909005558 Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403 637909005559 active site 637909005560 NTP binding site [chemical binding]; other site 637909005561 metal binding triad [ion binding]; metal-binding site 637909005562 antibiotic binding site [chemical binding]; other site 637909005563 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 637909005564 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 637909005565 non-specific DNA binding site [nucleotide binding]; other site 637909005566 salt bridge; other site 637909005567 sequence-specific DNA binding site [nucleotide binding]; other site 637909005568 Domain of unknown function (DUF955); Region: DUF955; pfam06114 637909005569 PemK-like protein; Region: PemK; cl00995 637909005570 RelB antitoxin; Region: RelB; cl01171 637909005571 pyridine nucleotide-disulfide oxidoreductase; Provisional; Region: PRK07251 637909005572 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 637909005573 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 637909005574 oxalate/formate antiporter family transporter; Region: 2A0111; TIGR00890 637909005575 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 637909005576 putative substrate translocation pore; other site 637909005577 Peptidyl-prolyl cis-trans isomerase (rotamase) - cyclophilin family [Posttranslational modification, protein turnover, chaperones]; Region: PpiB; COG0652 637909005578 active site 637909005579 Mn-dependent transcriptional regulator [Transcription]; Region: TroR; COG1321 637909005580 Iron dependent repressor, N-terminal DNA binding domain; Region: Fe_dep_repress; pfam01325 637909005581 Iron dependent repressor, metal binding and dimerisation domain; Region: Fe_dep_repr_C; pfam02742 637909005582 FeoA domain; Region: FeoA; pfam04023 637909005583 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Validated; Region: PRK05584 637909005584 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Region: MTA/SAH-Nsdase; TIGR01704 637909005585 DNA-directed RNA polymerase subunit B'; Validated; Region: PRK07225 637909005586 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 637909005587 dimer interface [polypeptide binding]; other site 637909005588 ADP-ribose binding site [chemical binding]; other site 637909005589 active site 637909005590 nudix motif; other site 637909005591 metal binding site [ion binding]; metal-binding site 637909005592 bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase; Provisional; Region: glmU; PRK14354 637909005593 N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540 637909005594 Substrate binding site; other site 637909005595 Mg++ binding site; other site 637909005596 N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353 637909005597 active site 637909005598 substrate binding site [chemical binding]; other site 637909005599 CoA binding site [chemical binding]; other site 637909005600 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 637909005601 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 637909005602 ASC-1 homology domain, subfamily similar to Enterococcus faecalis Ef3133. The ASCH domain, a small beta-barrel domain found in all three kingdoms of life, resembles the RNA-binding PUA domain and may also interact with RNA. ASCH has been proposed to...; Region: ASCH_Ef3133_like; cd06553 637909005603 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK06550 637909005604 classical (c) SDRs; Region: SDR_c; cd05233 637909005605 NAD(P) binding site [chemical binding]; other site 637909005606 active site 637909005607 Protein of unknown function (DUF2829); Region: DUF2829; pfam11195 637909005608 hypothetical protein; Validated; Region: PRK07668 637909005609 Predicted transcriptional regulators [Transcription]; Region: COG1695 637909005610 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 637909005611 FemAB family; Region: FemAB; pfam02388 637909005612 methionyl-tRNA synthetase; Reviewed; Region: PRK12267 637909005613 catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814 637909005614 active site 637909005615 HIGH motif; other site 637909005616 KMSKS motif; other site 637909005617 Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957 637909005618 tRNA binding surface [nucleotide binding]; other site 637909005619 anticodon binding site; other site 637909005620 tRNA-binding-domain-containing Escherichia coli methionyl-tRNA synthetase (EcMetRS)-like proteins. This family includes EcMetRS and Aquifex aeolicus Trbp111 (AaTrbp111). This domain has general tRNA binding properties. MetRS aminoacylates methionine...; Region: tRNA_bind_EcMetRS_like; cd02800 637909005621 dimer interface [polypeptide binding]; other site 637909005622 putative tRNA-binding site [nucleotide binding]; other site 637909005623 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 637909005624 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Thermotoga marina NorM; Region: MATE_NorM_like; cd13137 637909005625 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 637909005626 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 637909005627 Human Ape1-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: Ape1-like_AP-endo; cd09087 637909005628 active site 637909005629 putative catalytic site [active] 637909005630 DNA binding site [nucleotide binding] 637909005631 putative phosphate binding site [ion binding]; other site 637909005632 metal binding site A [ion binding]; metal-binding site 637909005633 AP binding site [nucleotide binding]; other site 637909005634 metal binding site B [ion binding]; metal-binding site 637909005635 Major Facilitator Superfamily; Region: MFS_1; pfam07690 637909005636 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 637909005637 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 637909005638 SnoaL-like domain; Region: SnoaL_3; pfam13474 637909005639 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 637909005640 active site 637909005641 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 637909005642 catalytic tetrad [active] 637909005643 short chain dehydrogenase; Provisional; Region: PRK06940 637909005644 classical (c) SDRs; Region: SDR_c; cd05233 637909005645 NAD(P) binding site [chemical binding]; other site 637909005646 active site 637909005647 Transcriptional regulator [Transcription]; Region: LysR; COG0583 637909005648 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 637909005649 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 637909005650 dimerization interface [polypeptide binding]; other site 637909005651 Arsenate Reductase (ArsC) family, unknown subfamily; uncharacterized proteins containing a CXXC motif with similarity to thioredoxin (TRX)-fold arsenic reductases, ArsC. Proteins containing a redox active CXXC motif like TRX and glutaredoxin (GRX)...; Region: ArsC_like; cd03036 637909005652 ArsC family; Region: ArsC; pfam03960 637909005653 putative ArsC-like catalytic residues; other site 637909005654 putative TRX-like catalytic residues [active] 637909005655 Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350 637909005656 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 637909005657 DNA binding site [nucleotide binding] 637909005658 active site 637909005659 Putative D-3-Phosphoglycerate Dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_like_3; cd12174 637909005660 D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain; Region: 2-Hacid_dh; pfam00389 637909005661 putative ligand binding site [chemical binding]; other site 637909005662 putative NAD binding site [chemical binding]; other site 637909005663 putative catalytic site [active] 637909005664 C-terminal ACT (regulatory) domain of D-3-Phosphoglycerate Dehydrogenase (3PGDH) found in fungi and bacteria; Region: ACT_3PGDH; cd04901 637909005665 L-serine binding site [chemical binding]; other site 637909005666 ACT domain interface; other site 637909005667 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 637909005668 3-phosphoserine/phosphohydroxythreonine aminotransferase; Provisional; Region: PRK05355 637909005669 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 637909005670 catalytic residue [active] 637909005671 Uncharacterized protein involved in copper resistance [Inorganic ion transport and metabolism]; Region: CutC; COG3142 637909005672 Nitrogen regulatory protein PII [Amino acid transport and metabolism]; Region: GlnK; COG0347 637909005673 Nitrogen regulatory protein P-II; Region: P-II; smart00938 637909005674 Ammonia permease [Inorganic ion transport and metabolism]; Region: AmtB; COG0004 637909005675 Predicted methyltransferases [General function prediction only]; Region: COG0313 637909005676 Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648 637909005677 putative SAM binding site [chemical binding]; other site 637909005678 putative homodimer interface [polypeptide binding]; other site 637909005679 DNA replication intiation control protein YabA; Reviewed; Region: PRK13169 637909005680 Uncharacterized homolog of PSP1 [Function unknown]; Region: COG1774 637909005681 DNA polymerase III subunit delta'; Validated; Region: PRK07276 637909005682 DNA polymerase III subunit delta'; Validated; Region: PRK08485 637909005683 thymidylate kinase; Validated; Region: tmk; PRK00698 637909005684 Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672 637909005685 TMP-binding site; other site 637909005686 ATP-binding site [chemical binding]; other site 637909005687 FOG: CBS domain [General function prediction only]; Region: COG0517 637909005688 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the acetoin utilization proteins in bacteria. Acetoin is a product of fermentative metabolism in many prokaryotic and eukaryotic microorganisms. They produce...; Region: CBS_pair_ACT_assoc2; cd04585 637909005689 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cd02116 637909005690 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 637909005691 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 637909005692 Walker A/P-loop; other site 637909005693 ATP binding site [chemical binding]; other site 637909005694 Q-loop/lid; other site 637909005695 ABC transporter signature motif; other site 637909005696 Walker B; other site 637909005697 D-loop; other site 637909005698 H-loop/switch region; other site 637909005699 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 637909005700 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 637909005701 Walker A/P-loop; other site 637909005702 ATP binding site [chemical binding]; other site 637909005703 Q-loop/lid; other site 637909005704 ABC transporter signature motif; other site 637909005705 Walker B; other site 637909005706 D-loop; other site 637909005707 H-loop/switch region; other site 637909005708 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 637909005709 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 637909005710 TM-ABC transporter signature motif; other site 637909005711 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 637909005712 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 637909005713 TM-ABC transporter signature motif; other site 637909005714 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 637909005715 Type I periplasmic ligand-binding domain of uncharacterized ABC (Atpase Binding Cassette)-type active transport systems that are predicted to be involved in uptake of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_ligand_binding_like_12; cd06347 637909005716 putative ligand binding site [chemical binding]; other site 637909005717 hypothetical protein; Provisional; Region: PRK02302 637909005718 Protein of unknown function (DUF964); Region: DUF964; pfam06133 637909005719 Protease subunit of ATP-dependent Clp proteases [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: ClpP; COG0740 637909005720 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 637909005721 oligomer interface [polypeptide binding]; other site 637909005722 active site residues [active] 637909005723 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 637909005724 EamA-like transporter family; Region: EamA; pfam00892 637909005725 Transcriptional regulator [Transcription]; Region: LysR; COG0583 637909005726 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 637909005727 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 637909005728 dimerization interface [polypeptide binding]; other site 637909005729 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 637909005730 active site 637909005731 Bifunctional PLP-dependent enzyme with beta-cystathionase and maltose regulon repressor activities [Amino acid transport and metabolism]; Region: MalY; COG1168 637909005732 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 637909005733 pyridoxal 5'-phosphate binding site [chemical binding]; other site 637909005734 homodimer interface [polypeptide binding]; other site 637909005735 catalytic residue [active] 637909005736 cystathionine gamma-synthase; Reviewed; Region: PRK07269 637909005737 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 637909005738 homodimer interface [polypeptide binding]; other site 637909005739 substrate-cofactor binding pocket; other site 637909005740 pyridoxal 5'-phosphate binding site [chemical binding]; other site 637909005741 catalytic residue [active] 637909005742 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 637909005743 Stage V sporulation protein B, also known as Stage III sporulation protein F, and related proteins; Region: MATE_SpoVB_like; cd13124 637909005744 UDP-N-acetylmuramoylalanyl-D-glutamate--L-lysine ligase; Provisional; Region: PRK14022 637909005745 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 637909005746 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 637909005747 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 637909005748 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 637909005749 Walker A/P-loop; other site 637909005750 ATP binding site [chemical binding]; other site 637909005751 Q-loop/lid; other site 637909005752 ABC transporter signature motif; other site 637909005753 Walker B; other site 637909005754 D-loop; other site 637909005755 H-loop/switch region; other site 637909005756 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 637909005757 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 637909005758 intersubunit interface [polypeptide binding]; other site 637909005759 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 637909005760 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 637909005761 ABC-ATPase subunit interface; other site 637909005762 dimer interface [polypeptide binding]; other site 637909005763 putative PBP binding regions; other site 637909005764 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 637909005765 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 637909005766 ABC-ATPase subunit interface; other site 637909005767 dimer interface [polypeptide binding]; other site 637909005768 putative PBP binding regions; other site 637909005769 Domain of unknown function (DUF1803); Region: DUF1803; pfam08820 637909005770 Domain of unknown function (DUF1803); Region: DUF1803; pfam08820 637909005771 Orthopoxvirus protein of unknown function (DUF830); Region: DUF830; pfam05708 637909005772 hypothetical protein; Validated; Region: PRK02101 637909005773 putative manganese-dependent inorganic pyrophosphatase; Provisional; Region: PRK05427 637909005774 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 637909005775 DHHA2 domain; Region: DHHA2; pfam02833 637909005776 pyruvate formate-lyase 1-activating enzyme; Region: PFLA; TIGR02493 637909005777 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 637909005778 FeS/SAM binding site; other site 637909005779 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 637909005780 Domain of unknown function DUF21; Region: DUF21; pfam01595 637909005781 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 637909005782 Transporter associated domain; Region: CorC_HlyC; smart01091 637909005783 NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025 637909005784 Putative rRNA methylase; Region: rRNA_methylase; pfam06962 637909005785 Predicted Fe-S oxidoreductase [General function prediction only]; Region: COG1242 637909005786 PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392 637909005787 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 637909005788 active site 637909005789 Predicted membrane protein [Function unknown]; Region: COG2510 637909005790 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3666 637909005791 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 637909005792 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 637909005793 Predicted membrane protein [Function unknown]; Region: COG3601 637909005794 Protein of unknown function (DUF3816); Region: DUF3816; pfam12822 637909005795 Predicted rRNA methylase (SpoU class) [Translation, ribosomal structure and biogenesis]; Region: CspR; COG0219 637909005796 short chain dehydrogenase; Provisional; Region: PRK07454 637909005797 classical (c) SDRs; Region: SDR_c; cd05233 637909005798 NAD(P) binding site [chemical binding]; other site 637909005799 active site 637909005800 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 637909005801 Helix-Turn-Helix DNA binding domain of the MerR-like transcription regulators YyaN and YraB; Region: HTH_YyaN; cd01109 637909005802 DNA binding residues [nucleotide binding] 637909005803 putative dimer interface [polypeptide binding]; other site 637909005804 Amino acid permease; Region: AA_permease_2; pfam13520 637909005805 K+ potassium transporter; Region: K_trans; cl15781 637909005806 potassium transporter peripheral membrane component; Reviewed; Region: trkA; PRK09496 637909005807 TrkA-N domain; Region: TrkA_N; pfam02254 637909005808 TrkA-C domain; Region: TrkA_C; pfam02080 637909005809 TrkA-N domain; Region: TrkA_N; pfam02254 637909005810 TrkA-C domain; Region: TrkA_C; pfam02080 637909005811 Trk-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: TrkG; COG0168 637909005812 potassium uptake protein, TrkH family; Region: 2a38; TIGR00933 637909005813 hypothetical protein; Validated; Region: PRK00041 637909005814 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 637909005815 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 637909005816 RNA binding surface [nucleotide binding]; other site 637909005817 Pseudouridine synthases, RsuA subfamily; Region: PseudoU_synth_RsuA_like; cd02870 637909005818 active site 637909005819 segregation and condensation protein B; Reviewed; Region: scpB; PRK00135 637909005820 segregation and condensation protein A; Reviewed; Region: scpA; PRK00104 637909005821 site-specific tyrosine recombinase XerD-like protein; Reviewed; Region: xerD; PRK02436 637909005822 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 637909005823 active site 637909005824 Int/Topo IB signature motif; other site 637909005825 catalytic residues [active] 637909005826 DNA binding site [nucleotide binding] 637909005827 FOG: CBS domain [General function prediction only]; Region: COG0517 637909005828 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_30; cd04643 637909005829 Escherichia coli YfcE and related proteins, metallophosphatase domain; Region: MPP_YfcE; cd00841 637909005830 active site 637909005831 metal binding site [ion binding]; metal-binding site 637909005832 homotetramer interface [polypeptide binding]; other site 637909005833 putative deoxyribonucleotide triphosphate pyrophosphatase/unknown domain fusion protein; Reviewed; Region: PRK02491 637909005834 NTPase/HAM1. This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515 637909005835 active site 637909005836 dimerization interface [polypeptide binding]; other site 637909005837 glutamate racemase; Provisional; Region: PRK00865 637909005838 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3763 637909005839 Diaminopimelate decarboxylase [Amino acid transport and metabolism]; Region: LysA; COG0019 637909005840 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828 637909005841 active site 637909005842 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 637909005843 substrate binding site [chemical binding]; other site 637909005844 catalytic residues [active] 637909005845 dimer interface [polypeptide binding]; other site 637909005846 Integral membrane protein, interacts with FtsH [General function prediction only]; Region: COG0670 637909005847 Bacterial BAX inhibitor (BI)-1/YccA-like proteins; Region: BI-1-like_bacterial; cd10432 637909005848 Predicted HD superfamily hydrolase [General function prediction only]; Region: COG1418 637909005849 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 637909005850 Zn2+ binding site [ion binding]; other site 637909005851 Mg2+ binding site [ion binding]; other site 637909005852 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 637909005853 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; smart00967 637909005854 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 637909005855 acylphosphatase; Provisional; Region: PRK14434 637909005856 OxaA-like protein precursor; Provisional; Region: PRK02463 637909005857 membrane protein insertase, YidC/Oxa1 family, C-terminal domain; Region: yidC_oxa1_cterm; TIGR03592 637909005858 transcription elongation factor GreA; Reviewed; Region: greA; PRK00226 637909005859 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 637909005860 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 637909005861 YceG-like family; Region: YceG; pfam02618 637909005862 proteins similar to Escherichia coli yceG; Region: yceG_like; cd08010 637909005863 dimerization interface [polypeptide binding]; other site 637909005864 Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247 637909005865 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 637909005866 Coenzyme A binding pocket [chemical binding]; other site 637909005867 UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421 637909005868 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 637909005869 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 637909005870 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 637909005871 Bacterial SNF2 helicase associated; Region: SNF2_assoc; pfam08455 637909005872 SNF2 family N-terminal domain; Region: SNF2_N; pfam00176 637909005873 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 637909005874 ATP binding site [chemical binding]; other site 637909005875 putative Mg++ binding site [ion binding]; other site 637909005876 Superfamily II DNA and RNA helicases [DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis]; Region: SrmB; COG0513 637909005877 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 637909005878 nucleotide binding region [chemical binding]; other site 637909005879 ATP-binding site [chemical binding]; other site 637909005880 GTP-binding protein Der; Reviewed; Region: PRK00093 637909005881 EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894 637909005882 G1 box; other site 637909005883 GTP/Mg2+ binding site [chemical binding]; other site 637909005884 Switch I region; other site 637909005885 G2 box; other site 637909005886 Switch II region; other site 637909005887 G3 box; other site 637909005888 G4 box; other site 637909005889 G5 box; other site 637909005890 EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895 637909005891 G1 box; other site 637909005892 GTP/Mg2+ binding site [chemical binding]; other site 637909005893 Switch I region; other site 637909005894 G2 box; other site 637909005895 G3 box; other site 637909005896 Switch II region; other site 637909005897 G4 box; other site 637909005898 G5 box; other site 637909005899 primosomal protein DnaI; Reviewed; Region: PRK08939 637909005900 Primosomal protein DnaI N-terminus; Region: DnaI_N; pfam07319 637909005901 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 637909005902 Walker A motif; other site 637909005903 ATP binding site [chemical binding]; other site 637909005904 Walker B motif; other site 637909005905 Replication initiation/membrane attachment protein [DNA replication, recombination, and repair]; Region: DnaB; COG3611 637909005906 Replication initiation and membrane attachment; Region: DnaB_2; cl12121 637909005907 transcriptional regulator NrdR; Validated; Region: nrdR; PRK00464 637909005908 ATP cone domain; Region: ATP-cone; pfam03477 637909005909 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 637909005910 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 637909005911 dimerization interface [polypeptide binding]; other site 637909005912 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 637909005913 dimer interface [polypeptide binding]; other site 637909005914 phosphorylation site [posttranslational modification] 637909005915 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 637909005916 ATP binding site [chemical binding]; other site 637909005917 Mg2+ binding site [ion binding]; other site 637909005918 G-X-G motif; other site 637909005919 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 637909005920 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 637909005921 active site 637909005922 phosphorylation site [posttranslational modification] 637909005923 intermolecular recognition site; other site 637909005924 dimerization interface [polypeptide binding]; other site 637909005925 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 637909005926 DNA binding site [nucleotide binding] 637909005927 Predicted metal-binding, possibly nucleic acid-binding protein [General function prediction only]; Region: COG1399 637909005928 heat shock protein HtpX; Provisional; Region: PRK04897 637909005929 Uncharacterized conserved protein [Function unknown]; Region: LemA; COG1704 637909005930 Predicted S-adenosylmethionine-dependent methyltransferase involved in bacterial cell division [Cell envelope biogenesis, outer membrane]; Region: GidB; COG0357 637909005931 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 637909005932 S-adenosylmethionine binding site [chemical binding]; other site 637909005933 Trk-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: TrkG; COG0168 637909005934 potassium uptake protein, TrkH family; Region: 2a38; TIGR00933 637909005935 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 637909005936 TrkA-N domain; Region: TrkA_N; pfam02254 637909005937 TrkA-C domain; Region: TrkA_C; pfam02080 637909005938 ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619 637909005939 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 637909005940 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 637909005941 Walker A/P-loop; other site 637909005942 ATP binding site [chemical binding]; other site 637909005943 Q-loop/lid; other site 637909005944 ABC transporter signature motif; other site 637909005945 Walker B; other site 637909005946 D-loop; other site 637909005947 H-loop/switch region; other site 637909005948 ATP-binding cassette cobalt transporter; Region: DUF3744; pfam12558 637909005949 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 637909005950 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 637909005951 Walker A/P-loop; other site 637909005952 ATP binding site [chemical binding]; other site 637909005953 Q-loop/lid; other site 637909005954 ABC transporter signature motif; other site 637909005955 Walker B; other site 637909005956 D-loop; other site 637909005957 H-loop/switch region; other site 637909005958 hypothetical protein; Provisional; Region: PRK13661 637909005959 Uncharacterized conserved protein [Function unknown]; Region: COG1912 637909005960 serine/threonine transporter SstT; Provisional; Region: PRK13628 637909005961 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 637909005962 Branched-chain amino acid transport protein; Region: Branch_AA_trans; cl00547 637909005963 biliverdin IX beta reductase (BVR-B, aka flavin reductase)-like proteins; atypical (a) SDRs; Region: BVR-B_like_SDR_a; cd05244 637909005964 NADH(P)-binding; Region: NAD_binding_10; pfam13460 637909005965 NAD binding site [chemical binding]; other site 637909005966 substrate binding site [chemical binding]; other site 637909005967 putative active site [active] 637909005968 Predicted transcriptional regulator [Transcription]; Region: COG1959 637909005969 Transcriptional regulator; Region: Rrf2; pfam02082 637909005970 Transcriptional regulator; Region: Rrf2; cl17282 637909005971 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 637909005972 dimer interface [polypeptide binding]; other site 637909005973 conserved gate region; other site 637909005974 ABC-ATPase subunit interface; other site 637909005975 ABC-type metal ion transport system, ATPase component [Inorganic ion transport and metabolism]; Region: AbcC; COG1135 637909005976 ATP-binding cassette domain of methionine transporter; Region: ABC_MetN_methionine_transporter; cd03258 637909005977 Walker A/P-loop; other site 637909005978 ATP binding site [chemical binding]; other site 637909005979 Q-loop/lid; other site 637909005980 ABC transporter signature motif; other site 637909005981 Walker B; other site 637909005982 D-loop; other site 637909005983 H-loop/switch region; other site 637909005984 NIL domain; Region: NIL; pfam09383 637909005985 hypothetical protein; Provisional; Region: PRK06446 637909005986 Uncharacterized M20 Dipeptidases; Region: M20_dipept_like_4; cd05681 637909005987 metal binding site [ion binding]; metal-binding site 637909005988 dimer interface [polypeptide binding]; other site 637909005989 ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464 637909005990 NLPA lipoprotein; Region: Lipoprotein_9; pfam03180 637909005991 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 637909005992 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 637909005993 substrate binding pocket [chemical binding]; other site 637909005994 membrane-bound complex binding site; other site 637909005995 hinge residues; other site 637909005996 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 637909005997 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 637909005998 metal binding site [ion binding]; metal-binding site 637909005999 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 637909006000 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 637909006001 substrate binding pocket [chemical binding]; other site 637909006002 membrane-bound complex binding site; other site 637909006003 hinge residues; other site 637909006004 Peptidase C26; Region: Peptidase_C26; pfam07722 637909006005 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_2; cd01745 637909006006 catalytic triad [active] 637909006007 hypothetical protein; Provisional; Region: PRK12378 637909006008 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 637909006009 active site turn [active] 637909006010 phosphorylation site [posttranslational modification] 637909006011 PTS system, glucose-like IIB component; Region: EIIB_glc; TIGR00826 637909006012 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 637909006013 Phosphotransferase system, EIIC; Region: PTS_EIIC; pfam02378 637909006014 Glycosyl hydrolase family 1; Region: Glyco_hydro_1; cl01046 637909006015 beta-galactosidase; Region: BGL; TIGR03356 637909006016 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 637909006017 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 637909006018 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 637909006019 putative active site [active] 637909006020 NmrA-like family; Region: NmrA; pfam05368 637909006021 triphenylmethane reductase (TMR)-like proteins, NMRa-like, atypical (a) SDRs; Region: TMR_SDR_a; cd05269 637909006022 NADP binding site [chemical binding]; other site 637909006023 Helix-Turn-Helix DNA binding domain of the transcription regulators TipAL, Mta, and SkgA; Region: HTH_TipAL-Mta; cd01106 637909006024 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 637909006025 DNA binding residues [nucleotide binding] 637909006026 dimer interface [polypeptide binding]; other site 637909006027 TipAS antibiotic-recognition domain; Region: TipAS; pfam07739 637909006028 hypothetical protein; Provisional; Region: PRK13670 637909006029 HIGH Nucleotidyl Transferase; Region: HIGH_NTase1; pfam05636 637909006030 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 637909006031 ATP binding site [chemical binding]; other site 637909006032 putative Mg++ binding site [ion binding]; other site 637909006033 helicase superfamily c-terminal domain; Region: HELICc; smart00490 637909006034 nucleotide binding region [chemical binding]; other site 637909006035 ATP-binding site [chemical binding]; other site 637909006036 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 637909006037 S-adenosylmethionine binding site [chemical binding]; other site 637909006038 Uncharacterized homolog of plant Iojap protein [Function unknown]; Region: COG0799 637909006039 Isochorismatase family; Region: Isochorismatase; pfam00857 637909006040 Nicotinamidase_ related amidohydrolases. Cysteine hydrolases of unknown function that share the catalytic triad with other amidohydrolases, like nicotinamidase, which converts nicotinamide to nicotinic acid and ammonia; Region: nicotinamidase_related; cd01014 637909006041 catalytic triad [active] 637909006042 conserved cis-peptide bond; other site 637909006043 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 637909006044 Zn2+ binding site [ion binding]; other site 637909006045 Mg2+ binding site [ion binding]; other site 637909006046 nicotinic acid mononucleotide adenylyltransferase; Provisional; Region: nadD; PRK00071 637909006047 Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165 637909006048 active site 637909006049 (T/H)XGH motif; other site 637909006050 Predicted RNA-binding protein containing KH domain, possibly ribosomal protein [Translation, ribosomal structure and biogenesis]; Region: COG1534 637909006051 GTPase YqeH; Provisional; Region: PRK13796 637909006052 Circularly permuted YqeH GTPase; Region: YqeH; cd01855 637909006053 GTP/Mg2+ binding site [chemical binding]; other site 637909006054 G4 box; other site 637909006055 G5 box; other site 637909006056 G1 box; other site 637909006057 Switch I region; other site 637909006058 G2 box; other site 637909006059 G3 box; other site 637909006060 Switch II region; other site 637909006061 Predicted hydrolase of the HAD superfamily [General function prediction only]; Region: COG2179 637909006062 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 637909006063 active site 637909006064 motif I; other site 637909006065 motif II; other site 637909006066 putative transposase OrfB; Reviewed; Region: PHA02517 637909006067 HTH-like domain; Region: HTH_21; pfam13276 637909006068 Integrase core domain; Region: rve; pfam00665 637909006069 Integrase core domain; Region: rve_2; pfam13333 637909006070 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 637909006071 Helix-turn-helix domain; Region: HTH_38; pfam13936 637909006072 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 637909006073 MarR family; Region: MarR_2; pfam12802 637909006074 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 637909006075 EamA-like transporter family; Region: EamA; pfam00892 637909006076 aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477 637909006077 GatB/GatE catalytic domain; Region: GatB_N; pfam02934 637909006078 GatB domain; Region: GatB_Yqey; pfam02637 637909006079 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 637909006080 aspartyl/glutamyl-tRNA amidotransferase subunit A; Reviewed; Region: gatA; PRK00012 637909006081 aspartyl/glutamyl-tRNA amidotransferase subunit C; Reviewed; Region: gatC; PRK00034 637909006082 Isochorismatase family; Region: Isochorismatase; pfam00857 637909006083 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 637909006084 catalytic triad [active] 637909006085 conserved cis-peptide bond; other site 637909006086 transcriptional repressor CodY; Validated; Region: PRK04158 637909006087 CodY GAF-like domain; Region: CodY; pfam06018 637909006088 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 637909006089 dimerization interface [polypeptide binding]; other site 637909006090 putative Zn2+ binding site [ion binding]; other site 637909006091 putative DNA binding site [nucleotide binding]; other site 637909006092 aminotransferase AlaT; Validated; Region: PRK09265 637909006093 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 637909006094 pyridoxal 5'-phosphate binding site [chemical binding]; other site 637909006095 homodimer interface [polypeptide binding]; other site 637909006096 catalytic residue [active] 637909006097 Membrane domain of glycerophosphoryl diester phosphodiesterase; Region: GPDPase_memb; cl01974 637909006098 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 637909006099 Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily; Region: PI-PLCc_GDPD_SF; cl14615 637909006100 active site 637909006101 catalytic site [active] 637909006102 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 637909006103 Ligand Binding Site [chemical binding]; other site 637909006104 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 637909006105 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 637909006106 active site 637909006107 motif I; other site 637909006108 motif II; other site 637909006109 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 637909006110 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 637909006111 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4696 637909006112 metal binding site [ion binding]; metal-binding site 637909006113 Type II (periplasmic) bacterial L-asparaginase; Region: L-asparaginase_II; cd08964 637909006114 active site 637909006115 homotetramer interface [polypeptide binding]; other site 637909006116 homodimer interface [polypeptide binding]; other site 637909006117 Predicted transcriptional regulator [Transcription]; Region: COG3655 637909006118 sequence-specific DNA binding site [nucleotide binding]; other site 637909006119 salt bridge; other site 637909006120 ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917 637909006121 RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488 637909006122 generic binding surface II; other site 637909006123 ssDNA binding site; other site 637909006124 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 637909006125 ATP binding site [chemical binding]; other site 637909006126 putative Mg++ binding site [ion binding]; other site 637909006127 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 637909006128 nucleotide binding region [chemical binding]; other site 637909006129 ATP-binding site [chemical binding]; other site 637909006130 alanine racemase; Reviewed; Region: alr; PRK00053 637909006131 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430 637909006132 active site 637909006133 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 637909006134 dimer interface [polypeptide binding]; other site 637909006135 substrate binding site [chemical binding]; other site 637909006136 catalytic residues [active] 637909006137 4'-phosphopantetheinyl transferase; Provisional; Region: acpS; PRK00070 637909006138 3-deoxy-D-arabino-heptulosonate 7-phosphate (DAHP) synthase [Amino acid transport and metabolism]; Region: AroG; cl17260 637909006139 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 637909006140 3-deoxy-D-arabino-heptulosonate 7-phosphate (DAHP) synthase [Amino acid transport and metabolism]; Region: AroG; COG0722 637909006141 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 637909006142 preprotein translocase subunit SecA; Reviewed; Region: PRK12904 637909006143 SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958 637909006144 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 637909006145 nucleotide binding region [chemical binding]; other site 637909006146 ATP-binding site [chemical binding]; other site 637909006147 SEC-C motif; Region: SEC-C; pfam02810 637909006148 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 637909006149 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 637909006150 nucleotide binding site [chemical binding]; other site 637909006151 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 637909006152 PTS system, sucrose-specific IIBC component; Region: PTS-II-BC-sucr; TIGR01996 637909006153 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 637909006154 active site turn [active] 637909006155 phosphorylation site [posttranslational modification] 637909006156 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 637909006157 PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_glc; cd00210 637909006158 HPr interaction site; other site 637909006159 glycerol kinase (GK) interaction site [polypeptide binding]; other site 637909006160 active site 637909006161 phosphorylation site [posttranslational modification] 637909006162 sucrose-6-phosphate hydrolase; Region: scrB_fam; TIGR01322 637909006163 Glycosyl hydrolase family 32, beta-fructosidases; Region: GH32_B_Fructosidase; cd08996 637909006164 substrate binding [chemical binding]; other site 637909006165 active site 637909006166 Glycosyl hydrolases family 32 C terminal; Region: Glyco_hydro_32C; pfam08244 637909006167 Transcriptional regulators [Transcription]; Region: PurR; COG1609 637909006168 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 637909006169 DNA binding site [nucleotide binding] 637909006170 domain linker motif; other site 637909006171 Ligand binding domain of the lacI-like transcription regulator from a novel metal-reducing bacterium Alkaliphilus Metalliredigens (strain Qymf) and its close homologs; Region: PBP1_Qymf_like; cd06291 637909006172 dimerization interface [polypeptide binding]; other site 637909006173 ligand binding site [chemical binding]; other site 637909006174 sodium binding site [ion binding]; other site 637909006175 transcription antitermination protein NusB; Reviewed; Region: nusB; PRK00202 637909006176 putative RNA binding site [nucleotide binding]; other site 637909006177 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1302 637909006178 elongation factor P; Validated; Region: PRK00529 637909006179 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 637909006180 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 637909006181 RNA binding site [nucleotide binding]; other site 637909006182 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 637909006183 RNA binding site [nucleotide binding]; other site 637909006184 Protein of unknown function (DUF2628); Region: DUF2628; pfam10947 637909006185 Tim44-like domain; Region: Tim44; cl09208 637909006186 Deoxycytidylate deaminase domain. Deoxycytidylate deaminase catalyzes the deamination of dCMP to dUMP, providing the nucleotide substrate for thymidylate synthase. The enzyme binds Zn++, which is required for catalytic activity. The activity of the...; Region: deoxycytidylate_deaminase; cd01286 637909006187 catalytic motif [active] 637909006188 Zn binding site [ion binding]; other site 637909006189 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 637909006190 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 637909006191 Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092 637909006192 active site 637909006193 Superinfection immunity protein; Region: Imm_superinfect; pfam14373 637909006194 PASTA domain. This domain is found at the C-termini of several Penicillin-binding proteins (PBPs) and bacterial serine/threonine kinases. It is a small globular fold consisting of 3 beta-sheets and an alpha-helix. The name PASTA is derived from PBP and...; Region: PASTA; cl02768 637909006195 PASTA domain. This domain is found at the C-termini of several Penicillin-binding proteins (PBPs) and bacterial serine/threonine kinases. It is a small globular fold consisting of 3 beta-sheets and an alpha-helix. The name PASTA is derived from PBP and...; Region: PASTA; cl02768 637909006196 excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349 637909006197 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 637909006198 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 637909006199 ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271 637909006200 Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598 637909006201 uncharacterized bacterial subfamily of the Escherichia coli CorA-Salmonella typhimurium ZntB family; Region: EcCorA_ZntB-like_u2; cd12827 637909006202 Cl binding site [ion binding]; other site 637909006203 oligomer interface [polypeptide binding]; other site 637909006204 Protein of unknown function (DUF1129); Region: DUF1129; cl11555 637909006205 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 637909006206 non-specific DNA binding site [nucleotide binding]; other site 637909006207 salt bridge; other site 637909006208 sequence-specific DNA binding site [nucleotide binding]; other site 637909006209 30S ribosomal protein S18; Reviewed; Region: rpsR; PRK00391 637909006210 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 637909006211 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 637909006212 dimer interface [polypeptide binding]; other site 637909006213 ssDNA binding site [nucleotide binding]; other site 637909006214 tetramer (dimer of dimers) interface [polypeptide binding]; other site 637909006215 30S ribosomal protein S6; Reviewed; Region: rpsF; PRK00453 637909006216 BioY family; Region: BioY; pfam02632 637909006217 AAA domain; Region: AAA_26; pfam13500 637909006218 dithiobiotin synthetase; Reviewed; Region: bioD; PRK00090 637909006219 biotin synthase; Region: bioB; TIGR00433 637909006220 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 637909006221 FeS/SAM binding site; other site 637909006222 Biotin and Thiamin Synthesis associated domain; Region: BATS; pfam06968 637909006223 alkyl hydroperoxide reductase subunit F; Provisional; Region: PRK15317 637909006224 Alkyl hydroperoxide reductase F subunit (AhpF) N-terminal domain (NTD) family, N-terminal TRX-fold subdomain; AhpF is a homodimeric flavoenzyme which catalyzes the NADH-dependent reduction of the peroxiredoxin AhpC, which in turn catalyzes the reduction...; Region: AhpF_NTD_N; cd02974 637909006225 catalytic residue [active] 637909006226 TRX-GRX-like family, Alkyl hydroperoxide reductase F subunit (AhpF) N-terminal domain (NTD) subfamily, C-terminal TRX-fold subdomain; AhpF is a homodimeric flavoenzyme which catalyzes the NADH-dependent reduction of the peroxiredoxin AhpC, which then...; Region: AhpF_NTD_C; cd03026 637909006227 catalytic residues [active] 637909006228 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 637909006229 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 637909006230 peroxiredoxin; Region: AhpC; TIGR03137 637909006231 Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015 637909006232 dimer interface [polypeptide binding]; other site 637909006233 decamer (pentamer of dimers) interface [polypeptide binding]; other site 637909006234 catalytic triad [active] 637909006235 peroxidatic and resolving cysteines [active] 637909006236 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 637909006237 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 637909006238 Walker A/P-loop; other site 637909006239 ATP binding site [chemical binding]; other site 637909006240 Q-loop/lid; other site 637909006241 ABC transporter signature motif; other site 637909006242 Walker B; other site 637909006243 D-loop; other site 637909006244 H-loop/switch region; other site 637909006245 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 637909006246 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 637909006247 dimer interface [polypeptide binding]; other site 637909006248 conserved gate region; other site 637909006249 putative PBP binding loops; other site 637909006250 ABC-ATPase subunit interface; other site 637909006251 ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728 637909006252 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 637909006253 substrate binding pocket [chemical binding]; other site 637909006254 membrane-bound complex binding site; other site 637909006255 hinge residues; other site 637909006256 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 637909006257 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 637909006258 Subfamily of fatty acid CoA ligase (FACL) similar to Fum10p of Gibberella moniliformis; Region: FACL_fum10p_like; cd05926 637909006259 acyl-activating enzyme (AAE) consensus motif; other site 637909006260 acyl-activating enzyme (AAE) consensus motif; other site 637909006261 putative AMP binding site [chemical binding]; other site 637909006262 putative active site [active] 637909006263 putative CoA binding site [chemical binding]; other site 637909006264 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 637909006265 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 637909006266 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 637909006267 acyl-activating enzyme (AAE) consensus motif; other site 637909006268 acyl-activating enzyme (AAE) consensus motif; other site 637909006269 AMP binding site [chemical binding]; other site 637909006270 active site 637909006271 CoA binding site [chemical binding]; other site 637909006272 Acyltransferase family; Region: Acyl_transf_3; pfam01757 637909006273 A/G-specific DNA glycosylase [DNA replication, recombination, and repair]; Region: MutY; COG1194 637909006274 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 637909006275 minor groove reading motif; other site 637909006276 helix-hairpin-helix signature motif; other site 637909006277 substrate binding pocket [chemical binding]; other site 637909006278 active site 637909006279 DNA glycosylase (MutY in bacteria and hMYH in humans) is responsible for repairing misread A*oxoG residues to C*G by removing the inappropriately paired adenine base from the DNA backbone. It belongs to the Nudix hydrolase superfamily and is important...; Region: DNA_Glycosylase_C; cd03431 637909006280 DNA binding and oxoG recognition site [nucleotide binding] 637909006281 oxalate/formate antiporter family transporter; Region: 2A0111; TIGR00890 637909006282 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 637909006283 putative substrate translocation pore; other site 637909006284 Predicted flavoprotein [General function prediction only]; Region: COG0431 637909006285 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 637909006286 Predicted flavoprotein [General function prediction only]; Region: COG0431 637909006287 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 637909006288 FMN-binding domain; Region: FMN_bind; pfam04205 637909006289 flavocytochrome c; Region: flavo_cyto_c; TIGR01813 637909006290 L-aspartate oxidase; Provisional; Region: PRK06175 637909006291 Protein of unknown function (DUF2992); Region: DUF2992; pfam11208 637909006292 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 637909006293 formaldehyde dehydrogenase (FDH)-like; Region: FDH_like_ADH3; cd08287 637909006294 catalytic Zn binding site [ion binding]; other site 637909006295 NAD(P) binding site [chemical binding]; other site 637909006296 structural Zn binding site [ion binding]; other site 637909006297 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 637909006298 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 637909006299 catalytic residues [active] 637909006300 PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cd01610 637909006301 active site 637909006302 Nicotinate-nucleotide pyrophosphorylase [Coenzyme metabolism]; Region: NadC; COG0157 637909006303 Quinolinate phosphoribosyl transferase (QAPRTase or QPRTase), also called nicotinate-nucleotide pyrophosphorylase, is involved in the de novo synthesis of NAD in both prokaryotes and eukaryotes. It catalyses the reaction of quinolinic acid (QA) with...; Region: QPRTase; cd01572 637909006304 dimerization interface [polypeptide binding]; other site 637909006305 active site 637909006306 L-aspartate oxidase; Provisional; Region: PRK06175 637909006307 FAD binding domain; Region: FAD_binding_2; pfam00890 637909006308 Quinolinate synthetase A protein; Region: NadA; pfam02445 637909006309 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 637909006310 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 637909006311 ATP-binding cassette domain of multidrug resistance protein-like transporters; Region: ABCC_MRP_Like; cd03228 637909006312 Walker A/P-loop; other site 637909006313 ATP binding site [chemical binding]; other site 637909006314 Q-loop/lid; other site 637909006315 ABC transporter signature motif; other site 637909006316 Walker B; other site 637909006317 D-loop; other site 637909006318 H-loop/switch region; other site 637909006319 Mismatch repair ATPase (MutS family) [DNA replication, recombination, and repair]; Region: COG1193 637909006320 MutS domain III; Region: MutS_III; pfam05192 637909006321 ATP-binding cassette domain of MutS2; Region: ABC_MutS2; cd03280 637909006322 Walker A/P-loop; other site 637909006323 ATP binding site [chemical binding]; other site 637909006324 Q-loop/lid; other site 637909006325 ABC transporter signature motif; other site 637909006326 Walker B; other site 637909006327 D-loop; other site 637909006328 H-loop/switch region; other site 637909006329 Smr domain; Region: Smr; pfam01713 637909006330 Uncharacterized membrane protein, required for colicin V production [General function prediction only]; Region: CvpA; COG1286 637909006331 Colicin V production protein; Region: Colicin_V; pfam02674 637909006332 Protein of unknown function (DUF1211); Region: DUF1211; pfam06736 637909006333 Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer, utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cl00514 637909006334 FMN binding site [chemical binding]; other site 637909006335 dimer interface [polypeptide binding]; other site 637909006336 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 637909006337 Old yellow enzyme (OYE)-related FMN binding domain, group 4. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a reducing agent with oxygens, quinones, and alpha,beta-unsaturated aldehydes and ketones, and can act as...; Region: OYE_like_4_FMN; cd04735 637909006338 putative active site [active] 637909006339 putative FMN binding site [chemical binding]; other site 637909006340 putative substrate binding site [chemical binding]; other site 637909006341 putative catalytic residue [active] 637909006342 Predicted transcriptional regulators [Transcription]; Region: COG1733 637909006343 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 637909006344 ribonuclease HIII; Provisional; Region: PRK00996 637909006345 Domain of unknown function (DUF3378); Region: DUF3378; pfam11858 637909006346 bacterial Ribonuclease HIII-like; Region: RNase_HII_bacteria_HIII_like; cd06590 637909006347 RNA/DNA hybrid binding site [nucleotide binding]; other site 637909006348 active site 637909006349 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 637909006350 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 637909006351 Catalytic site [active] 637909006352 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 637909006353 helicase, putative, RecD/TraA family; Region: recD_rel; TIGR01448 637909006354 H3TH domains of structure-specific 5' nucleases (or flap endonuclease-1-like) involved in DNA replication, repair, and recombination; Region: H3TH_StructSpec-5'-nucleases; cl14815 637909006355 AAA domain; Region: AAA_30; pfam13604 637909006356 Family description; Region: UvrD_C_2; pfam13538 637909006357 DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586 637909006358 active site 637909006359 DNA polymerase IV; Validated; Region: PRK02406 637909006360 DNA binding site [nucleotide binding] 637909006361 formate acetyltransferase 1; Region: pyr_form_ly_1; TIGR01255 637909006362 Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939 637909006363 Acetyltransferase (GNAT) domain; Region: Acetyltransf_5; cl17496 637909006364 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 637909006365 Coenzyme A binding pocket [chemical binding]; other site 637909006366 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 637909006367 Beta-lactamase; Region: Beta-lactamase; pfam00144 637909006368 Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cd00333 637909006369 amphipathic channel; other site 637909006370 Asn-Pro-Ala signature motifs; other site 637909006371 x-prolyl-dipeptidyl aminopeptidase; Provisional; Region: PRK05371 637909006372 X-Prolyl dipeptidyl aminopeptidase PepX, N-terminal; Region: PepX_N; pfam09168 637909006373 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 637909006374 X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain; Region: PepX_C; pfam08530 637909006375 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 637909006376 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 637909006377 dimer interface [polypeptide binding]; other site 637909006378 phosphorylation site [posttranslational modification] 637909006379 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 637909006380 ATP binding site [chemical binding]; other site 637909006381 Mg2+ binding site [ion binding]; other site 637909006382 G-X-G motif; other site 637909006383 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 637909006384 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 637909006385 active site 637909006386 phosphorylation site [posttranslational modification] 637909006387 intermolecular recognition site; other site 637909006388 dimerization interface [polypeptide binding]; other site 637909006389 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 637909006390 DNA binding site [nucleotide binding] 637909006391 phosphate transport system regulatory protein PhoU; Region: phoU_full; TIGR02135 637909006392 PhoU domain; Region: PhoU; pfam01895 637909006393 PhoU domain; Region: PhoU; pfam01895 637909006394 phosphate transporter ATP-binding protein; Provisional; Region: PRK14240 637909006395 ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260 637909006396 Walker A/P-loop; other site 637909006397 ATP binding site [chemical binding]; other site 637909006398 Q-loop/lid; other site 637909006399 ABC transporter signature motif; other site 637909006400 Walker B; other site 637909006401 D-loop; other site 637909006402 H-loop/switch region; other site 637909006403 phosphate ABC transporter, permease protein PstA; Region: 3a0107s02c; TIGR00974 637909006404 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 637909006405 dimer interface [polypeptide binding]; other site 637909006406 conserved gate region; other site 637909006407 putative PBP binding loops; other site 637909006408 ABC-ATPase subunit interface; other site 637909006409 phosphate ABC transporter, permease protein PstC; Region: phosphate_pstC; TIGR02138 637909006410 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 637909006411 dimer interface [polypeptide binding]; other site 637909006412 conserved gate region; other site 637909006413 putative PBP binding loops; other site 637909006414 ABC-ATPase subunit interface; other site 637909006415 PBP superfamily domain; Region: PBP_like_2; cl17296 637909006416 PBP superfamily domain; Region: PBP_like_2; cl17296 637909006417 hypothetical protein; Validated; Region: PRK00153 637909006418 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 637909006419 Helix-Turn-Helix DNA binding domain of the transcription regulators TipAL, Mta, and SkgA; Region: HTH_TipAL-Mta; cd01106 637909006420 DNA binding residues [nucleotide binding] 637909006421 dimer interface [polypeptide binding]; other site 637909006422 DNA polymerase III, epsilon subunit and related 3'-5' exonucleases [DNA replication, recombination, and repair]; Region: DnaQ; COG0847 637909006423 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 637909006424 active site 637909006425 catalytic site [active] 637909006426 substrate binding site [chemical binding]; other site 637909006427 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cl17220 637909006428 HI0933-like protein; Region: HI0933_like; pfam03486 637909006429 hydroxyglutarate oxidase; Provisional; Region: PRK11728 637909006430 Chromate resistance exported protein; Region: Chrome_Resist; cl01744 637909006431 30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08881 637909006432 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 637909006433 Coenzyme A binding pocket [chemical binding]; other site 637909006434 Threonine aldolase [Amino acid transport and metabolism]; Region: GLY1; COG2008 637909006435 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 637909006436 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 637909006437 catalytic residue [active] 637909006438 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 637909006439 Winged helix DNA-binding domain; Region: HTH_27; pfam13463 637909006440 Predicted membrane protein [Function unknown]; Region: COG4392 637909006441 Predicted branched-chain amino acid permease (azaleucine resistance) [Amino acid transport and metabolism]; Region: AzlC; COG1296 637909006442 Hexulose-6-phosphate isomerase (PHI). PHI is a member of the SIS (Sugar ISomerase domain) superfamily. In the ribulose monophosphate pathway of formaldehyde fixation, hexulose-6-phosphate synthase catalyzes the condensation of ribulose-5-phosphate with...; Region: SIS_PHI; cd05005 637909006443 tetramer interface [polypeptide binding]; other site 637909006444 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 637909006445 active site 637909006446 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 637909006447 active site 637909006448 phosphorylation site [posttranslational modification] 637909006449 PTS_IIB_galactitol: subunit IIB of enzyme II (EII) of the galactitol-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is a galactitol-specific permease with two cytoplasmic domains (IIA and IIB) and a...; Region: PTS_IIB_galactitol; cd05566 637909006450 active site 637909006451 P-loop; other site 637909006452 phosphorylation site [posttranslational modification] 637909006453 Phosphotransferase system, galactitol-specific IIC component [Carbohydrate transport and metabolism]; Region: GatC; COG3775 637909006454 PTS system sugar-specific permease component; Region: EIIC-GAT; cl04451 637909006455 Ribose/Galactose Isomerase; Region: LacAB_rpiB; cl00485 637909006456 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 637909006457 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 637909006458 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 637909006459 UGMP family protein; Validated; Region: PRK09604 637909006460 tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725 637909006461 Carbamoyltransferase; Region: CmcH_NodU; pfam02543 637909006462 ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575 637909006463 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 637909006464 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 637909006465 Coenzyme A binding pocket [chemical binding]; other site 637909006466 tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725 637909006467 Glycoprotease family; Region: Peptidase_M22; pfam00814 637909006468 hypothetical protein; Provisional; Region: PRK13667 637909006469 mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595 637909006470 Metallo-beta-lactamase superfamily; Region: Lactamase_B; pfam00753 637909006471 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 637909006472 FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388 637909006473 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 637909006474 Surface antigen [General function prediction only]; Region: COG3942 637909006475 CHAP domain; Region: CHAP; cl17642 637909006476 glutamate synthase subunit beta; Reviewed; Region: gltD; PRK12810 637909006477 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 637909006478 Formate/glycerate dehydrogenases, D-specific 2-hydroxy acid dehydrogenases and related dehydrogenases; Region: FDH_GDH_like; cl17240 637909006479 NAD binding site [chemical binding]; other site 637909006480 glutamate synthase subunit alpha; Provisional; Region: gltB; PRK11750 637909006481 Glutamine amidotransferases class-II (Gn-AT), glutamate synthase (GltS)-type. GltS is a homodimer that synthesizes L-glutamate from 2-oxoglutarate and L-glutamine, an important step in ammonia assimilation in bacteria, cyanobacteria and plants. The...; Region: GltS; cd00713 637909006482 active site 637909006483 dimer interface [polypeptide binding]; other site 637909006484 Glutamate synthase central domain; Region: Glu_syn_central; pfam04898 637909006485 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808 637909006486 active site 637909006487 FMN binding site [chemical binding]; other site 637909006488 substrate binding site [chemical binding]; other site 637909006489 3Fe-4S cluster binding site [ion binding]; other site 637909006490 gltb_C. This domain is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS). GltS encodes a complex iron-sulfur flavoprotein that catalyzes the synthesis of L-glutamate from L-glutamine and 2-oxoglutarate. It requires the...; Region: gltB_C; cd00982 637909006491 domain interface; other site 637909006492 Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174 637909006493 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 637909006494 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 637909006495 Helix-Turn-Helix DNA binding domain of GlnR-like transcription regulators; Region: HTH_GlnR-like; cd01105 637909006496 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 637909006497 DNA binding residues [nucleotide binding] 637909006498 putative dimer interface [polypeptide binding]; other site 637909006499 Predicted membrane protein [Function unknown]; Region: COG4129 637909006500 phosphoglycerate kinase; Provisional; Region: pgk; PRK00073 637909006501 Phosphoglycerate kinase; Region: PGK; pfam00162 637909006502 substrate binding site [chemical binding]; other site 637909006503 hinge regions; other site 637909006504 ADP binding site [chemical binding]; other site 637909006505 catalytic site [active] 637909006506 Glyceraldehyde-3-phosphate dehydrogenase/erythrose-4-phosphate dehydrogenase [Carbohydrate transport and metabolism]; Region: GapA; COG0057 637909006507 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846 637909006508 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 637909006509 elongation factor G; Reviewed; Region: PRK00007 637909006510 Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886 637909006511 G1 box; other site 637909006512 putative GEF interaction site [polypeptide binding]; other site 637909006513 GTP/Mg2+ binding site [chemical binding]; other site 637909006514 Switch I region; other site 637909006515 G2 box; other site 637909006516 G3 box; other site 637909006517 Switch II region; other site 637909006518 G4 box; other site 637909006519 G5 box; other site 637909006520 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 637909006521 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 637909006522 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 637909006523 30S ribosomal protein S7; Validated; Region: PRK05302 637909006524 S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368 637909006525 S17 interaction site [polypeptide binding]; other site 637909006526 S8 interaction site; other site 637909006527 16S rRNA interaction site [nucleotide binding]; other site 637909006528 streptomycin interaction site [chemical binding]; other site 637909006529 23S rRNA interaction site [nucleotide binding]; other site 637909006530 aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site 637909006531 pur operon repressor; Provisional; Region: PRK09213 637909006532 Bacterial purine repressor, N-terminal; Region: PuR_N; pfam09182 637909006533 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 637909006534 active site 637909006535 Predicted HD-superfamily hydrolase [General function prediction only]; Region: COG3481 637909006536 YhaM_OBF_like: A subfamily of OB folds similar to that found in Bacillus subtilis YhaM and Staphylococcus aureus cmp-binding factor-1 (SaCBF1). Both these proteins are 3'-to-5'exoribonucleases. YhaM requires Mn2+ or Co2+ for activity and is...; Region: YhaM_OBF_like; cd04492 637909006537 generic binding surface II; other site 637909006538 generic binding surface I; other site 637909006539 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 637909006540 Zn2+ binding site [ion binding]; other site 637909006541 Mg2+ binding site [ion binding]; other site 637909006542 Predicted nuclease of restriction endonuclease-like fold, RmuC family [General function prediction only]; Region: COG1322 637909006543 RmuC family; Region: RmuC; pfam02646 637909006544 Thiamine pyrophosphokinase [Coenzyme metabolism]; Region: THI80; COG1564 637909006545 Thiamine pyrophosphokinase; Region: TPK; cd07995 637909006546 active site 637909006547 dimerization interface [polypeptide binding]; other site 637909006548 thiamine binding site [chemical binding]; other site 637909006549 Pentose-5-phosphate-3-epimerase [Carbohydrate transport and metabolism]; Region: Rpe; COG0036 637909006550 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 637909006551 substrate binding site [chemical binding]; other site 637909006552 hexamer interface [polypeptide binding]; other site 637909006553 metal binding site [ion binding]; metal-binding site 637909006554 GTPase RsgA; Reviewed; Region: PRK00098 637909006555 S1_YloQ_GTPase: YloQ GTase family (also known as YjeQ and CpgA), S1-like RNA-binding domain. Proteins in the YloQ GTase family bind the ribosome and have GTPase activity. The precise role of this family is unknown. The protein structure is composed of...; Region: S1_YloQ_GTPase; cd04466 637909006556 RNA binding site [nucleotide binding]; other site 637909006557 homodimer interface [polypeptide binding]; other site 637909006558 Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854 637909006559 GTPase/Zn-binding domain interface [polypeptide binding]; other site 637909006560 GTP/Mg2+ binding site [chemical binding]; other site 637909006561 G4 box; other site 637909006562 G1 box; other site 637909006563 Switch I region; other site 637909006564 G2 box; other site 637909006565 G3 box; other site 637909006566 Switch II region; other site 637909006567 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 637909006568 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 637909006569 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cl17736 637909006570 active site 637909006571 phosphorylation site [posttranslational modification] 637909006572 intermolecular recognition site; other site 637909006573 dimerization interface [polypeptide binding]; other site 637909006574 LytTr DNA-binding domain; Region: LytTR; pfam04397 637909006575 Enterocin A Immunity; Region: EntA_Immun; pfam08951 637909006576 Enterocin A Immunity; Region: EntA_Immun; pfam08951 637909006577 Protein of unknown function (DUF3884); Region: DUF3884; pfam13024 637909006578 Predicted signal transduction protein with a C-terminal ATPase domain [Signal transduction mechanisms]; Region: COG2972 637909006579 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 637909006580 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 637909006581 active site 637909006582 phosphorylation site [posttranslational modification] 637909006583 intermolecular recognition site; other site 637909006584 dimerization interface [polypeptide binding]; other site 637909006585 LytTr DNA-binding domain; Region: LytTR; pfam04397 637909006586 LytTr DNA-binding domain; Region: LytTR; pfam04397 637909006587 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 637909006588 Bacteriocin class II with double-glycine leader peptide; Region: Bacteriocin_IIc; pfam10439 637909006589 A sub-family of peptidase family C39. Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various...; Region: Peptidase_C39B; cd02418 637909006590 ABC-type bacteriocin transporter; Region: bacteriocin_ABC; TIGR01193 637909006591 putative active site [active] 637909006592 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 637909006593 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 637909006594 Walker A/P-loop; other site 637909006595 ATP binding site [chemical binding]; other site 637909006596 Q-loop/lid; other site 637909006597 ABC transporter signature motif; other site 637909006598 Walker B; other site 637909006599 D-loop; other site 637909006600 H-loop/switch region; other site 637909006601 bacteriocin secretion accessory protein; Region: bacteriocin_acc; TIGR01000 637909006602 HlyD family secretion protein; Region: HlyD_3; pfam13437 637909006603 CAAX protease self-immunity; Region: Abi; pfam02517 637909006604 CAAX protease self-immunity; Region: Abi; pfam02517 637909006605 16S ribosomal RNA methyltransferase KsgA/Dim1 family protein; Reviewed; Region: ksgA; PRK00274 637909006606 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 637909006607 S-adenosylmethionine binding site [chemical binding]; other site 637909006608 Protein of unknown function (DUF1697); Region: DUF1697; pfam08002 637909006609 ribonuclease M5; Region: 5S_RNA_mat_M5; TIGR00334 637909006610 TOPRIM_ RNase M5_like: The topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain found in Ribonuclease M5: (RNase M5) and other small primase-like proteins from bacteria and archaea. RNase M5 catalyzes the maturation of 5S rRNA in low...; Region: TOPRIM_RNase_M5_like; cd01027 637909006611 putative active site [active] 637909006612 putative metal binding site [ion binding]; other site 637909006613 Domain of unknown function (DUF4093); Region: DUF4093; pfam13331 637909006614 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 637909006615 Predicted metal-dependent hydrolases with the TIM-barrel fold [General function prediction only]; Region: COG1099 637909006616 active site 637909006617 TQXA domain; Region: TQXA_dom; TIGR03934 637909006618 Repeat unit of collagen-binding protein domain B; Region: CollagenBindB; cd00222 637909006619 domain interaction interfaces [polypeptide binding]; other site 637909006620 Repeat unit of collagen-binding protein domain B; Region: CollagenBindB; cd00222 637909006621 domain interaction interfaces [polypeptide binding]; other site 637909006622 Repeat unit of collagen-binding protein domain B; Region: CollagenBindB; cd00222 637909006623 domain interaction interfaces [polypeptide binding]; other site 637909006624 Repeat unit of collagen-binding protein domain B; Region: CollagenBindB; cd00222 637909006625 domain interaction interfaces [polypeptide binding]; other site 637909006626 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3666 637909006627 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 637909006628 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 637909006629 L-lactate dehydrogenase; Reviewed; Region: ldh; PRK00066 637909006630 L-2-hydroxyisocapronate dehydrogenases and some bacterial L-lactate dehydrogenases; Region: HicDH_like; cd05291 637909006631 tetramer (dimer of dimers) interface [polypeptide binding]; other site 637909006632 NAD binding site [chemical binding]; other site 637909006633 dimer interface [polypeptide binding]; other site 637909006634 substrate binding site [chemical binding]; other site 637909006635 CAAX protease self-immunity; Region: Abi; pfam02517 637909006636 heavy metal-(Cd/Co/Hg/Pb/Zn)-translocating P-type ATPase; Region: ATPase-IB2_Cd; TIGR01512 637909006637 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 637909006638 Condensing enzymes; Family of enzymes that catalyze a (decarboxylating or non-decarboxylating) Claisen-like condensation reaction. Members are share strong structural similarity, and are involved in the synthesis and degradation of fatty acids, and the...; Region: cond_enzymes; cl09938 637909006639 Soluble P-type ATPase [General function prediction only]; Region: COG4087 637909006640 Transposase; Region: DDE_Tnp_ISL3; pfam01610 637909006641 Sortase C (SrtC) or subfamily-3 sortases are membrane cysteine transpeptidases found in Gram-positive bacteria that anchor surface proteins to peptidoglycans of the bacterial cell wall envelope. This involves a transpeptidation reaction in which the...; Region: Sortase_C_3; cd05827 637909006642 active site 637909006643 catalytic site [active] 637909006644 LPXTG-motif cell wall anchor domain; Region: LPXTG_anchor; TIGR01167 637909006645 Listeria-Bacteroides repeat domain (List_Bact_rpt); Region: Flg_new; pfam09479 637909006646 Listeria-Bacteroides repeat domain (List_Bact_rpt); Region: Flg_new; pfam09479 637909006647 Listeria-Bacteroides repeat domain (List_Bact_rpt); Region: Flg_new; pfam09479 637909006648 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 637909006649 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 637909006650 Catalytic site [active] 637909006651 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 637909006652 S-adenosylmethionine binding site [chemical binding]; other site 637909006653 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 637909006654 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 637909006655 ATP-binding cassette domain of multidrug resistance protein-like transporters; Region: ABCC_MRP_Like; cd03228 637909006656 Walker A/P-loop; other site 637909006657 ATP binding site [chemical binding]; other site 637909006658 Q-loop/lid; other site 637909006659 ABC transporter signature motif; other site 637909006660 Walker B; other site 637909006661 D-loop; other site 637909006662 H-loop/switch region; other site 637909006663 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 637909006664 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 637909006665 ABC-ATPase subunit interface; other site 637909006666 dimer interface [polypeptide binding]; other site 637909006667 putative PBP binding regions; other site 637909006668 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 637909006669 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 637909006670 ABC-type metal ion transport system, periplasmic component/surface adhesin [Inorganic ion transport and metabolism]; Region: LraI; COG0803 637909006671 Metal binding protein PsaA. These proteins have been shown to function as initial receptors in ABC transport of Mn2+ and as surface adhesins in some eubacterial species. They belong to the TroA superfamily of periplasmic metal binding proteins that...; Region: PsaA; cd01137 637909006672 metal binding site [ion binding]; metal-binding site 637909006673 2-hydroxycarboxylate transporter family; Region: 2HCT; pfam03390 637909006674 malate dehydrogenase; Provisional; Region: PRK13529 637909006675 Malic enzyme, N-terminal domain; Region: malic; pfam00390 637909006676 NAD(P) binding domain of malic enzyme (ME), subgroup 1; Region: NAD_bind_1_malic_enz; cd05312 637909006677 NAD(P) binding site [chemical binding]; other site 637909006678 Transcriptional regulator [Transcription]; Region: LysR; COG0583 637909006679 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 637909006680 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 637909006681 dimerization interface [polypeptide binding]; other site 637909006682 Predicted esterase [General function prediction only]; Region: COG0400 637909006683 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 637909006684 D-alanyl-lipoteichoic acid biosynthesis protein DltD; Region: LTA_DltD; TIGR04092 637909006685 DltD N-terminal region; Region: DltD_N; pfam04915 637909006686 DltD central region; Region: DltD_M; pfam04918 637909006687 DltD C-terminal region; Region: DltD_C; pfam04914 637909006688 D-alanine--poly(phosphoribitol) ligase subunit 2; Validated; Region: PRK05087 637909006689 D-alanyl-lipoteichoic acid biosynthesis protein DltB; Region: LTA_dltB; TIGR04091 637909006690 D-alanine--poly(phosphoribitol) ligase subunit 1; Provisional; Region: PRK04813 637909006691 D-alanine:D-alanyl carrier protein ligase (DltA); Region: DltA; cd05945 637909006692 acyl-activating enzyme (AAE) consensus motif; other site 637909006693 AMP binding site [chemical binding]; other site 637909006694 D-Ala-teichoic acid biosynthesis protein; Region: DUF3687; pfam12459 637909006695 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3237 637909006696 V-type ATP synthase subunit D; Reviewed; Region: PRK00373 637909006697 V-type ATP synthase subunit B; Provisional; Region: PRK04196 637909006698 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 637909006699 V/A-type ATP synthase (non-catalytic) subunit B. These ATPases couple ATP hydrolysis to the build up of a H+ gradient, but V-type ATPases do not catalyze the reverse reaction. The Vacuolar (V-type) ATPase is found in the membranes of vacuoles, the golgi...; Region: V_A-ATPase_B; cd01135 637909006700 Walker A motif homologous position; other site 637909006701 Walker B motif; other site 637909006702 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 637909006703 V-type ATP synthase subunit A; Provisional; Region: PRK04192 637909006704 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 637909006705 V/A-type ATP synthase catalytic subunit A. These ATPases couple ATP hydrolysis to the build up of a H+ gradient, but V-type ATPases do not catalyze the reverse reaction. The Vacuolar (V-type) ATPase is found in the membranes of vacuoles, the golgi...; Region: V_A-ATPase_A; cd01134 637909006706 Walker A motif/ATP binding site; other site 637909006707 Walker B motif; other site 637909006708 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 637909006709 V-type ATP synthase subunit F; Provisional; Region: PRK01395 637909006710 Archaeal/vacuolar-type H+-ATPase subunit C [Energy production and conversion]; Region: NtpC; COG1527 637909006711 V-type ATP synthase subunit C; Provisional; Region: PRK01198; cl00660 637909006712 V-type ATP synthase subunit K; Validated; Region: PRK06558 637909006713 ATP synthase subunit C; Region: ATP-synt_C; pfam00137 637909006714 V-type ATP synthase subunit I; Validated; Region: PRK05771 637909006715 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 637909006716 Major Facilitator Superfamily; Region: MFS_1; pfam07690 637909006717 putative substrate translocation pore; other site 637909006718 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 637909006719 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 637909006720 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 637909006721 Ribosomal protein L34; Region: Ribosomal_L34; cl00370 637909006722 Protein of unknown function (DUF3021); Region: DUF3021; pfam11457 637909006723 LytTr DNA-binding domain; Region: LytTR; smart00850 637909006724 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 637909006725 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 637909006726 Walker A/P-loop; other site 637909006727 ATP binding site [chemical binding]; other site 637909006728 Q-loop/lid; other site 637909006729 ABC transporter signature motif; other site 637909006730 Walker B; other site 637909006731 D-loop; other site 637909006732 H-loop/switch region; other site 637909006733 Predicted RNA-binding protein [General function prediction only]; Region: Jag; COG1847 637909006734 jag_K homology RNA-binding domain. The KH domain is found in proteins homologous to the Bacillus subtilis protein Jag, which is associated with SpoIIIJ and is necessary for the third stage of sporulation. The KH motif is a beta-alpha-alpha-beta-beta...; Region: jag_KH; cd02414 637909006735 G-X-X-G motif; other site 637909006736 R3H domain found in proteins homologous to Bacillus subtilus Jag, which is associated with SpoIIIJ. SpoIIIJ is necessary for the third stage of sporulation. The name of the R3H domain comes from the characteristic spacing of the most conserved arginine...; Region: R3H_jag; cd02644 637909006737 RxxxH motif; other site 637909006738 Preprotein translocase subunit YidC [Intracellular trafficking and secretion]; Region: YidC; COG0706 637909006739 membrane protein insertase, YidC/Oxa1 family, C-terminal domain; Region: yidC_oxa1_cterm; TIGR03592 637909006740 ribonuclease P; Reviewed; Region: rnpA; PRK00499 637909006741 argininosuccinate lyase; Provisional; Region: PRK00855 637909006742 Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359 637909006743 active sites [active] 637909006744 tetramer interface [polypeptide binding]; other site 637909006745 argininosuccinate synthase; Provisional; Region: PRK13820 637909006746 Argininosuccinate synthase. The Argininosuccinate synthase is a urea cycle enzyme that catalyzes the penultimate step in arginine biosynthesis: the ATP-dependent ligation of citrulline to aspartate to form argininosuccinate, AMP and pyrophosphate . In...; Region: Argininosuccinate_Synthase; cd01999 637909006747 ANP binding site [chemical binding]; other site 637909006748 Substrate Binding Site II [chemical binding]; other site 637909006749 Substrate Binding Site I [chemical binding]; other site 637909006750 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 637909006751 H+ Antiporter protein; Region: 2A0121; TIGR00900 637909006752 putative substrate translocation pore; other site 637909006753 Cyanate permease [Inorganic ion transport and metabolism]; Region: CynX; COG2807 637909006754 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 637909006755 putative substrate translocation pore; other site 637909006756 glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406 637909006757 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 637909006758 active site 637909006759 HIGH motif; other site 637909006760 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 637909006761 active site 637909006762 KMSKS motif; other site 637909006763 Tubby C 2; Region: Tub_2; cl02043 637909006764 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeD; cd03379 637909006765 active site clefts [active] 637909006766 zinc binding site [ion binding]; other site 637909006767 dimer interface [polypeptide binding]; other site 637909006768 DNA repair protein RadA; Provisional; Region: PRK11823 637909006769 Sms (bacterial radA) DNA repair protein. This protein is not related to archael radA any more than is to other RecA-like NTPases. Sms has a role in recombination and recombinational repair and is responsible for the stabilization or processing of...; Region: Sms; cd01121 637909006770 Walker A motif/ATP binding site; other site 637909006771 ATP binding site [chemical binding]; other site 637909006772 Walker B motif; other site 637909006773 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 637909006774 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 637909006775 trimer interface [polypeptide binding]; other site 637909006776 active site 637909006777 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1636 637909006778 NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094 637909006779 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 637909006780 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479 637909006781 Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541 637909006782 dTDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: RfbA; COG1209 637909006783 active site 637909006784 tetramer interface; other site 637909006785 Rhomboid family; Region: Rhomboid; pfam01694 637909006786 5,10-methenyltetrahydrofolate synthetase; Region: MTHFS_bact; TIGR02727 637909006787 5-formyltetrahydrofolate cyclo-ligase family; Region: 5-FTHF_cyc-lig; pfam01812 637909006788 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 637909006789 M20 Peptidase Aminoacyclase-1 YkuR-like proteins, including YkuR and Ama/HipO/HyuC proteins; Region: M20_Acy1_YkuR_like; cd05670 637909006790 metal binding site [ion binding]; metal-binding site 637909006791 putative dimer interface [polypeptide binding]; other site 637909006792 Tetrahydrodipicolinate succinyltransferase N-terminal; Region: DapH_N; pfam08503 637909006793 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-acetyltransferase; Region: DapD_Ac; TIGR03532 637909006794 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate (THDP) N-succinyltransferase (also called THP succinyltransferase): THDP N-succinyltransferase catalyzes the conversion of tetrahydrodipicolinate and succinyl-CoA to N-succinyltetrahydrodipicolinate and CoA; Region: LbH_THP_succinylT; cd03350 637909006795 trimer interface [polypeptide binding]; other site 637909006796 active site 637909006797 substrate binding site [chemical binding]; other site 637909006798 CoA binding site [chemical binding]; other site 637909006799 glucose-6-phosphate isomerase; Provisional; Region: pgi; PRK14097 637909006800 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015 637909006801 active site 637909006802 dimer interface [polypeptide binding]; other site 637909006803 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016 637909006804 dimer interface [polypeptide binding]; other site 637909006805 active site 637909006806 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 637909006807 nucleoside/Zn binding site; other site 637909006808 dimer interface [polypeptide binding]; other site 637909006809 catalytic motif [active] 637909006810 Metal-dependent hydrolases of the beta-lactamase superfamily III [General function prediction only]; Region: ElaC; COG1234 637909006811 Uncharacterized conserved protein [General function prediction only]; Region: BioY; COG1268 637909006812 Zinc finger domain containing protein (CHY type) [Function unknown]; Region: COG4357 637909006813 CHY zinc finger; Region: zf-CHY; pfam05495 637909006814 queuine tRNA-ribosyltransferase; Provisional; Region: tgt; PRK00112 637909006815 Queuine/archaeosine tRNA-ribosyltransferase [Translation, ribosomal structure and biogenesis]; Region: Tgt; COG0343 637909006816 Protein of unknown function (DUF975); Region: DUF975; cl10504 637909006817 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 637909006818 metal binding site 2 [ion binding]; metal-binding site 637909006819 putative DNA binding helix; other site 637909006820 metal binding site 1 [ion binding]; metal-binding site 637909006821 dimer interface [polypeptide binding]; other site 637909006822 structural Zn2+ binding site [ion binding]; other site 637909006823 Phenolic acid decarboxylase (PAD); Region: PA_decarbox; pfam05870 637909006824 Predicted transcriptional regulators [Transcription]; Region: COG1695 637909006825 Transcriptional regulator PadR-like family; Region: PadR; cl17335 637909006826 Virulence activator alpha C-term; Region: Vir_act_alpha_C; pfam10400 637909006827 Predicted CoA-binding protein [General function prediction only]; Region: COG1832 637909006828 DNA polymerase I; Provisional; Region: PRK05755 637909006829 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 637909006830 active site 637909006831 metal binding site 1 [ion binding]; metal-binding site 637909006832 putative 5' ssDNA interaction site; other site 637909006833 metal binding site 3; metal-binding site 637909006834 metal binding site 2 [ion binding]; metal-binding site 637909006835 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 637909006836 putative DNA binding site [nucleotide binding]; other site 637909006837 putative metal binding site [ion binding]; other site 637909006838 inactive DEDDy 3'-5' exonuclease domain of Bacillus stearothermophilus DNA polymerase I and similar family-A DNA polymerases; Region: DNA_polA_I_Bacillus_like_exo; cd06140 637909006839 Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637 637909006840 active site 637909006841 DNA binding site [nucleotide binding] 637909006842 catalytic site [active] 637909006843 Membrane transport protein; Region: Mem_trans; pfam03547 637909006844 Transketolase [Carbohydrate transport and metabolism]; Region: TktA; COG0021 637909006845 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 637909006846 TPP-binding site [chemical binding]; other site 637909006847 dimer interface [polypeptide binding]; other site 637909006848 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 637909006849 PYR/PP interface [polypeptide binding]; other site 637909006850 dimer interface [polypeptide binding]; other site 637909006851 TPP binding site [chemical binding]; other site 637909006852 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 637909006853 Transaldolase-like fructose-6-phosphate aldolases (FSA) found in bacteria and archaea; Region: Transaldolase_FSA; cd00956 637909006854 active site 637909006855 intersubunit interactions; other site 637909006856 catalytic residue [active] 637909006857 putative L-ascorbate 6-phosphate lactonase; Provisional; Region: PRK11709 637909006858 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 637909006859 Transcriptional antiterminator [Transcription]; Region: BglG; COG3711 637909006860 Mga helix-turn-helix domain; Region: Mga; pfam05043 637909006861 PRD domain; Region: PRD; pfam00874 637909006862 PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568 637909006863 active site 637909006864 P-loop; other site 637909006865 phosphorylation site [posttranslational modification] 637909006866 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 637909006867 active site 637909006868 phosphorylation site [posttranslational modification] 637909006869 2-keto-3-deoxy-6-phosphogluconate aldolase [Carbohydrate transport and metabolism]; Region: Eda; COG0800 637909006870 KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452 637909006871 active site 637909006872 intersubunit interface [polypeptide binding]; other site 637909006873 catalytic residue [active] 637909006874 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 637909006875 Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408 637909006876 inhibitor site; inhibition site 637909006877 active site 637909006878 dimer interface [polypeptide binding]; other site 637909006879 catalytic residue [active] 637909006880 KpsF-like protein. KpsF is an arabinose-5-phosphate isomerase which contains SIS (Sugar ISomerase) domains. SIS domains are found in many phosphosugar isomerases and phosphosugar binding proteins. KpsF catalyzes the reversible reaction of ribulose...; Region: SIS_Kpsf; cd05014 637909006881 putative active site [active] 637909006882 PTS system ascorbate-specific transporter subunit IIC; Reviewed; Region: PRK12997 637909006883 PTS_IIB_ascorbate: subunit IIB of enzyme II (EII) of the L-ascorbate-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is an L-ascorbate-specific permease with two cytoplasmic subunits (IIA and IIB) and a...; Region: PTS_IIB_ascorbate; cd05563 637909006884 active site 637909006885 P-loop; other site 637909006886 phosphorylation site [posttranslational modification] 637909006887 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 637909006888 active site 637909006889 phosphorylation site [posttranslational modification] 637909006890 Transcriptional antiterminator [Transcription]; Region: BglG; COG3711 637909006891 PRD domain; Region: PRD; pfam00874 637909006892 PRD domain; Region: PRD; pfam00874 637909006893 PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568 637909006894 active site 637909006895 P-loop; other site 637909006896 phosphorylation site [posttranslational modification] 637909006897 L-ribulose-5-phosphate 4-epimerase; Provisional; Region: araD; PRK13145 637909006898 L-ribulose-5-phosphate 4-epimerase; Reviewed; Region: araD; PRK08193 637909006899 intersubunit interface [polypeptide binding]; other site 637909006900 active site 637909006901 Zn2+ binding site [ion binding]; other site 637909006902 putative L-xylulose 5-phosphate 3-epimerase; Reviewed; Region: PRK13210 637909006903 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cd00019 637909006904 AP (apurinic/apyrimidinic) site pocket; other site 637909006905 DNA interaction; other site 637909006906 Metal-binding active site; metal-binding site 637909006907 3-Keto-L-gulonate 6-phosphate decarboxylase (KGPDC) and D-arabino-3-hexulose-6-phosphate synthase (HPS). KGPDC catalyzes the formation of L-xylulose 5-phosphate and carbon dioxide from 3-keto-L-gulonate 6-phosphate as part of the anaerobic pathway for...; Region: KGPDC_HPS; cd04726 637909006908 active site 637909006909 dimer interface [polypeptide binding]; other site 637909006910 magnesium binding site [ion binding]; other site 637909006911 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 637909006912 active site 637909006913 phosphorylation site [posttranslational modification] 637909006914 PTS_IIB_ascorbate: subunit IIB of enzyme II (EII) of the L-ascorbate-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is an L-ascorbate-specific permease with two cytoplasmic subunits (IIA and IIB) and a...; Region: PTS_IIB_ascorbate; cd05563 637909006915 active site 637909006916 P-loop; other site 637909006917 phosphorylation site [posttranslational modification] 637909006918 PTS system ascorbate-specific transporter subunit IIC; Reviewed; Region: PRK12997 637909006919 Uncharacterized conserved protein [Function unknown]; Region: COG2128 637909006920 Uncharacterized oxidoreductases, Fe-dependent alcohol dehydrogenase family [Energy production and conversion]; Region: COG1979 637909006921 Dehydroquinate synthase-like (DHQ-like) and iron-containing alcohol dehydrogenases (Fe-ADH); Region: DHQ_Fe-ADH; cl02872 637909006922 active site 637909006923 NAD binding site [chemical binding]; other site 637909006924 metal binding site [ion binding]; metal-binding site 637909006925 ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464 637909006926 NLPA lipoprotein; Region: Lipoprotein_9; pfam03180 637909006927 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 637909006928 ABC-ATPase subunit interface; other site 637909006929 DL-methionine transporter ATP-binding subunit; Provisional; Region: metN; PRK11153 637909006930 ATP-binding cassette domain of methionine transporter; Region: ABC_MetN_methionine_transporter; cd03258 637909006931 Walker A/P-loop; other site 637909006932 ATP binding site [chemical binding]; other site 637909006933 Q-loop/lid; other site 637909006934 ABC transporter signature motif; other site 637909006935 Walker B; other site 637909006936 D-loop; other site 637909006937 H-loop/switch region; other site 637909006938 NIL domain; Region: NIL; pfam09383 637909006939 Transcriptional regulator; Region: Rrf2; cl17282 637909006940 Rrf2 family protein; Region: rrf2_super; TIGR00738 637909006941 Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788 637909006942 Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108 637909006943 GDP-binding site [chemical binding]; other site 637909006944 ACT binding site; other site 637909006945 IMP binding site; other site 637909006946 bifunctional glutamate--cysteine ligase/glutathione synthetase; Provisional; Region: PRK02471 637909006947 Glutamate-cysteine ligase; Region: Glu_cys_ligase; cl17352 637909006948 ATP-grasp domain; Region: ATP-grasp_4; cl17255 637909006949 phage transcriptional regulator, ArpU family; Region: phage_arpU; TIGR01637 637909006950 D5 N terminal like; Region: D5_N; smart00885 637909006951 phage/plasmid primase, P4 family, C-terminal domain; Region: primase_Cterm; TIGR01613 637909006952 Poxvirus D5 protein-like; Region: Pox_D5; pfam03288 637909006953 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 637909006954 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 637909006955 non-specific DNA binding site [nucleotide binding]; other site 637909006956 salt bridge; other site 637909006957 sequence-specific DNA binding site [nucleotide binding]; other site 637909006958 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 637909006959 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 637909006960 non-specific DNA binding site [nucleotide binding]; other site 637909006961 salt bridge; other site 637909006962 sequence-specific DNA binding site [nucleotide binding]; other site 637909006963 Domain of unknown function (DUF955); Region: DUF955; pfam06114 637909006964 Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582 637909006965 phiLC3 phage and phage-related integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes various bacterial (mainly gram positive) and phage integrases, including those similar to Lactococcus...; Region: INT_phiLC3_C; cd01189 637909006966 Int/Topo IB signature motif; other site 637909006967 Uncharacterized protein involved in tellurite resistance [Inorganic ion transport and metabolism]; Region: TelA; COG3853 637909006968 LytTr DNA-binding domain; Region: LytTR; smart00850 637909006969 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 637909006970 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 637909006971 Walker A/P-loop; other site 637909006972 ATP binding site [chemical binding]; other site 637909006973 Q-loop/lid; other site 637909006974 ABC transporter signature motif; other site 637909006975 Walker B; other site 637909006976 D-loop; other site 637909006977 H-loop/switch region; other site 637909006978 This family is the oxydase domain of NRPS (non-ribosomal peptide synthetase) and other proteins that modify polypeptides by cyclizing a thioester to form a ring. These include epoB, part of the epothilone biosynthesis pathway; tubD, part of the tubulysin...; Region: mcbC-like_oxidoreductase; cd02142 637909006979 NADPH bind site [chemical binding]; other site 637909006980 YcaO-like family; Region: YcaO; pfam02624 637909006981 thiazole/oxazole-forming peptide maturase, SagD family component; Region: TOMM_cyclo_SagD; TIGR03604 637909006982 Hsp33-like chaperonin; Reviewed; Region: hslO; PRK00114 637909006983 Heat shock protein 33 (Hsp33): Cytosolic protein that acts as a molecular chaperone under oxidative conditions. In normal (reducing) cytosolic conditions, four conserved Cys residues are coordinated by a Zn ion. Under oxidative stress (such as heat...; Region: Hsp33; cd00498 637909006984 dimerization interface [polypeptide binding]; other site 637909006985 domain crossover interface; other site 637909006986 redox-dependent activation switch; other site 637909006987 putative TIM-barrel protein, nifR3 family; Region: nifR3_yhdG; TIGR00737 637909006988 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 637909006989 FMN binding site [chemical binding]; other site 637909006990 active site 637909006991 catalytic residues [active] 637909006992 substrate binding site [chemical binding]; other site 637909006993 ATP-binding subunits of Clp protease and DnaK/DnaJ chaperones [Posttranslational modification, protein turnover, chaperones]; Region: clpA; COG0542 637909006994 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 637909006995 Walker A motif; other site 637909006996 ATP binding site [chemical binding]; other site 637909006997 Walker B motif; other site 637909006998 arginine finger; other site 637909006999 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 637909007000 Walker A motif; other site 637909007001 ATP binding site [chemical binding]; other site 637909007002 Walker B motif; other site 637909007003 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 637909007004 Firmicute transcriptional repressor of class III stress genes (CtsR); Region: CtsR; pfam05848 637909007005 Putative small multi-drug export protein; Region: Sm_multidrug_ex; pfam06695 637909007006 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 637909007007 non-specific DNA binding site [nucleotide binding]; other site 637909007008 salt bridge; other site 637909007009 sequence-specific DNA binding site [nucleotide binding]; other site 637909007010 H+ Antiporter protein; Region: 2A0121; TIGR00900 637909007011 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 637909007012 putative substrate translocation pore; other site 637909007013 elongation factor Ts; Provisional; Region: tsf; PRK09377 637909007014 UBA/TS-N domain; Region: UBA; pfam00627 637909007015 Elongation factor TS; Region: EF_TS; pfam00889 637909007016 Elongation factor TS; Region: EF_TS; pfam00889 637909007017 Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425 637909007018 rRNA interaction site [nucleotide binding]; other site 637909007019 S8 interaction site; other site 637909007020 putative laminin-1 binding site; other site 637909007021 Microcin C7 self-immunity protein determines resistance to exogenous microcin C7; Region: Peptidase_S66_mccF_like; cd07062 637909007022 putative dimer interface [polypeptide binding]; other site 637909007023 catalytic triad [active] 637909007024 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 637909007025 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 637909007026 non-specific DNA binding site [nucleotide binding]; other site 637909007027 salt bridge; other site 637909007028 sequence-specific DNA binding site [nucleotide binding]; other site 637909007029 transcriptional activator, Rgg/GadR/MutR family, C-terminal domain; Region: RGG_Cterm; TIGR01716 637909007030 Predicted metalloendopeptidase [Posttranslational modification, protein turnover, chaperones]; Region: PepO; COG3590 637909007031 Peptidase family M13 includes neprilysin, endothelin-converting enzyme I; Region: M13; cd08662 637909007032 active site 637909007033 Zn binding site [ion binding]; other site 637909007034 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 637909007035 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 637909007036 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 637909007037 alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403 637909007038 Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333 637909007039 Ca binding site [ion binding]; other site 637909007040 active site 637909007041 catalytic site [active] 637909007042 PTS system, trehalose-specific IIBC component; Region: PTS-IIBC-Tre; TIGR01992 637909007043 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 637909007044 active site turn [active] 637909007045 phosphorylation site [posttranslational modification] 637909007046 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 637909007047 Phosphotransferase system IIA components [Carbohydrate transport and metabolism]; Region: NagE; COG2190 637909007048 HPr interaction site; other site 637909007049 glycerol kinase (GK) interaction site [polypeptide binding]; other site 637909007050 active site 637909007051 phosphorylation site [posttranslational modification] 637909007052 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 637909007053 DNA-binding site [nucleotide binding]; DNA binding site 637909007054 trehalose operon repressor, B. subtilis-type; Region: trehalos_R_Bsub; TIGR02404 637909007055 UTRA domain; Region: UTRA; pfam07702 637909007056 Sortase C (SrtC) or subfamily-3 sortases are membrane cysteine transpeptidases found in Gram-positive bacteria that anchor surface proteins to peptidoglycans of the bacterial cell wall envelope. This involves a transpeptidation reaction in which the...; Region: Sortase_C_3; cd05827 637909007057 active site 637909007058 catalytic site [active] 637909007059 fimbrial isopeptide formation D2 domain; Region: RrgB_K2N_iso_D2; TIGR04226 637909007060 Cna protein B-type domain; Region: Cna_B; pfam05738 637909007061 LPXTG-motif cell wall anchor domain; Region: LPXTG_anchor; TIGR01167 637909007062 Collagen binding domain; Region: Collagen_bind; pfam05737 637909007063 Repeat unit of collagen-binding protein domain B; Region: CollagenBindB; cd00222 637909007064 domain interaction interfaces [polypeptide binding]; other site 637909007065 Repeat unit of collagen-binding protein domain B; Region: CollagenBindB; cd00222 637909007066 domain interaction interfaces [polypeptide binding]; other site 637909007067 Repeat unit of collagen-binding protein domain B; Region: CollagenBindB; cd00222 637909007068 domain interaction interfaces [polypeptide binding]; other site 637909007069 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 637909007070 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 637909007071 Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080 637909007072 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 637909007073 Walker A motif; other site 637909007074 ATP binding site [chemical binding]; other site 637909007075 Walker B motif; other site 637909007076 arginine finger; other site 637909007077 Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491 637909007078 4Fe-4S single cluster domain; Region: Fer4_12; pfam13353 637909007079 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 637909007080 FeS/SAM binding site; other site 637909007081 Predicted acetyltransferase [General function prediction only]; Region: COG3981 637909007082 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 637909007083 anaerobic ribonucleoside triphosphate reductase; Provisional; Region: PRK09263 637909007084 ATP cone domain; Region: ATP-cone; pfam03477 637909007085 Class III ribonucleotide reductase; Region: RNR_III; cd01675 637909007086 effector binding site; other site 637909007087 active site 637909007088 Zn binding site [ion binding]; other site 637909007089 glycine loop; other site 637909007090 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 637909007091 hypothetical protein; Provisional; Region: PRK13678 637909007092 Holliday junction resolvase-like protein; Reviewed; Region: PRK00109 637909007093 hypothetical protein; Provisional; Region: PRK05473 637909007094 Arsenate Reductase (ArsC) family, Spx subfamily; Spx is a unique RNA polymerase (RNAP)-binding protein present in bacilli and some mollicutes. It inhibits transcription by binding to the C-terminal domain of the alpha subunit of RNAP, disrupting complex...; Region: ArsC_Spx; cd03032 637909007095 ArsC family; Region: ArsC; pfam03960 637909007096 putative catalytic residues [active] 637909007097 thiol/disulfide switch; other site 637909007098 recombinase A; Provisional; Region: recA; PRK09354 637909007099 RecA is a bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response. RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983 637909007100 hexamer interface [polypeptide binding]; other site 637909007101 Walker A motif; other site 637909007102 ATP binding site [chemical binding]; other site 637909007103 Walker B motif; other site 637909007104 competence damage-inducible protein A; Provisional; Region: PRK00549 637909007105 Competence-damaged protein. CinA is the first gene in the competence- inducible (cin) operon and is thought to be specifically required at some stage in the process of transformation. This domain is closely related to a domain, found in a variety of...; Region: cinA; cd00885 637909007106 putative MPT binding site; other site 637909007107 Uncharacterized protein (competence- and mitomycin-induced) [General function prediction only]; Region: CinA; COG1546 637909007108 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 637909007109 Major Facilitator Superfamily; Region: MFS_1; pfam07690 637909007110 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 637909007111 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 637909007112 non-specific DNA binding site [nucleotide binding]; other site 637909007113 salt bridge; other site 637909007114 sequence-specific DNA binding site [nucleotide binding]; other site 637909007115 Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116 637909007116 RuvA N terminal domain; Region: RuvA_N; pfam01330 637909007117 DNA mismatch repair protein; Reviewed; Region: mutL; PRK00095 637909007118 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 637909007119 ATP binding site [chemical binding]; other site 637909007120 Mg2+ binding site [ion binding]; other site 637909007121 G-X-G motif; other site 637909007122 MutL_Trans: transducer domain, having a ribosomal S5 domain 2-like fold, conserved in the C-terminal domain of DNA mismatch repair (MutL/MLH1/PMS2) family. This transducer domain is homologous to the second domain of the DNA gyrase B subunit, which is...; Region: MutL_Trans; cd00782 637909007123 ATP binding site [chemical binding]; other site 637909007124 MutL C terminal dimerisation domain; Region: MutL_C; pfam08676 637909007125 DNA mismatch repair protein MutS; Provisional; Region: PRK05399 637909007126 MutS domain I; Region: MutS_I; pfam01624 637909007127 MutS domain II; Region: MutS_II; pfam05188 637909007128 MutS domain III; Region: MutS_III; pfam05192 637909007129 ATP-binding cassette domain of MutS1 homolog; Region: ABC_MutS1; cd03284 637909007130 Walker A/P-loop; other site 637909007131 ATP binding site [chemical binding]; other site 637909007132 Q-loop/lid; other site 637909007133 ABC transporter signature motif; other site 637909007134 Walker B; other site 637909007135 D-loop; other site 637909007136 H-loop/switch region; other site 637909007137 Protein of unknown function (DUF964); Region: DUF964; cl01483 637909007138 Arginine repressor, DNA binding domain; Region: Arg_repressor; pfam01316 637909007139 arginine repressor; Region: argR_whole; TIGR01529 637909007140 Arginine repressor, C-terminal domain; Region: Arg_repressor_C; pfam02863 637909007141 arginyl-tRNA synthetase; Reviewed; Region: PRK12451 637909007142 Arginyl tRNA synthetase N terminal dom; Region: Arg_tRNA_synt_N; smart01016 637909007143 catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671 637909007144 active site 637909007145 HIGH motif; other site 637909007146 KMSK motif region; other site 637909007147 Anticodon-binding domain of arginyl tRNA synthetases; Region: Anticodon_Ia_Arg; cd07956 637909007148 tRNA binding surface [nucleotide binding]; other site 637909007149 anticodon binding site; other site 637909007150 Enterocin A Immunity; Region: EntA_Immun; pfam08951 637909007151 Predicted peptidase [General function prediction only]; Region: COG4099 637909007152 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 637909007153 Uncharacterized conserved protein [Function unknown]; Region: COG1284 637909007154 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 637909007155 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 637909007156 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 637909007157 Uncharacterized conserved protein [Function unknown]; Region: COG1284 637909007158 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 637909007159 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 637909007160 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 637909007161 aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476 637909007162 EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317 637909007163 dimer interface [polypeptide binding]; other site 637909007164 anticodon binding site; other site 637909007165 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777 637909007166 homodimer interface [polypeptide binding]; other site 637909007167 motif 1; other site 637909007168 active site 637909007169 motif 2; other site 637909007170 GAD domain; Region: GAD; pfam02938 637909007171 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777 637909007172 motif 3; other site 637909007173 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 637909007174 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 637909007175 non-specific DNA binding site [nucleotide binding]; other site 637909007176 salt bridge; other site 637909007177 sequence-specific DNA binding site [nucleotide binding]; other site 637909007178 histidyl-tRNA synthetase; Reviewed; Region: hisS; PRK00037 637909007179 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 637909007180 dimer interface [polypeptide binding]; other site 637909007181 motif 1; other site 637909007182 active site 637909007183 motif 2; other site 637909007184 HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859 637909007185 anticodon binding site; other site 637909007186 50S ribosomal protein L32; Validated; Region: rpmF; PRK01110 637909007187 50S ribosomal protein L33; Validated; Region: rpmG; PRK00595 637909007188 AAA domain; Region: AAA_21; pfam13304 637909007189 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 637909007190 Walker B; other site 637909007191 D-loop; other site 637909007192 H-loop/switch region; other site 637909007193 Cro/C1-type HTH DNA-binding domain; Region: HTH_26; pfam13443 637909007194 glycosyltransferase family protein; Region: PLN02208 637909007195 DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674 637909007196 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 637909007197 Plasmid replication protein; Region: Rep_2; pfam01719 637909007198 Helix-turn-helix domain; Region: HTH_17; cl17695 637909007199 phiLC3 phage and phage-related integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes various bacterial (mainly gram positive) and phage integrases, including those similar to Lactococcus...; Region: INT_phiLC3_C; cd01189 637909007200 Int/Topo IB signature motif; other site 637909007201 Antibiotic biosynthesis monooxygenase; Region: ABM; pfam03992 637909007202 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 637909007203 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 637909007204 Coenzyme A binding pocket [chemical binding]; other site 637909007205 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 637909007206 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 637909007207 putative DNA binding site [nucleotide binding]; other site 637909007208 dimerization interface [polypeptide binding]; other site 637909007209 putative Zn2+ binding site [ion binding]; other site 637909007210 Predicted transcriptional regulators [Transcription]; Region: COG1695 637909007211 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 637909007212 Predicted membrane protein [Function unknown]; Region: COG4709 637909007213 Domain of unknown function (DUF4097); Region: DUF4097; pfam13349 637909007214 Domain of unknown function (DUF4098); Region: DUF4098; pfam13345 637909007215 Predicted membrane protein [Function unknown]; Region: COG3759 637909007216 Predicted membrane protein [Function unknown]; Region: COG1511 637909007217 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061 637909007218 X-X-X-Leu-X-X-Gly heptad repeats; Region: xxxLxxG_by_4; TIGR03057 637909007219 YhgE/Pip C-terminal domain; Region: pip_yhgE_Cterm; TIGR03062 637909007220 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 637909007221 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 637909007222 30S ribosomal protein S4; Validated; Region: rpsD; PRK05327 637909007223 Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163 637909007224 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 637909007225 RNA binding surface [nucleotide binding]; other site 637909007226 Uncharacterized protein conserved in bacteria [Function unknown]; Region: Veg; COG4466 637909007227 replicative DNA helicase; Provisional; Region: PRK05748 637909007228 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 637909007229 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 637909007230 Walker A motif; other site 637909007231 ATP binding site [chemical binding]; other site 637909007232 Walker B motif; other site 637909007233 DNA binding loops [nucleotide binding] 637909007234 50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137 637909007235 Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281 637909007236 Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948 637909007237 Predicted signaling protein consisting of a modified GGDEF domain and a DHH domain [Signal transduction mechanisms]; Region: COG3887 637909007238 Class III nucleotidyl cyclases; Region: Nucleotidyl_cyc_III; cl11967 637909007239 DHH family; Region: DHH; pfam01368 637909007240 DHHA1 domain; Region: DHHA1; pfam02272 637909007241 tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA; Validated; Region: PRK05192 637909007242 tRNA:m(5)U-54 methyltransferase; Region: gid_trmFO; TIGR00137 637909007243 GidA associated domain 3; Region: GIDA_assoc_3; pfam13932 637909007244 hypothetical protein; Provisional; Region: PRK09273 637909007245 Ribose/Galactose Isomerase; Region: LacAB_rpiB; pfam02502 637909007246 Predicted tRNA(5-methylaminomethyl-2-thiouridylate) methyltransferase, contains the PP-loop ATPase domain [Translation, ribosomal structure and biogenesis]; Region: TrmU; COG0482 637909007247 tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998 637909007248 L-serine dehydratase, iron-sulfur-dependent, beta subunit; Region: sda_beta; TIGR00719 637909007249 Serine dehydratase beta chain; Region: SDH_beta; pfam03315 637909007250 C-terminal ACT domain of the L-serine dehydratase (LSD), iron-sulfur-dependent, beta subunit; Region: ACT_LSD; cd04903 637909007251 putative L-serine binding site [chemical binding]; other site 637909007252 Serine dehydratase alpha chain; Region: SDH_alpha; cl12120 637909007253 L-serine deaminase [Amino acid transport and metabolism]; Region: SdaA; COG1760 637909007254 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 637909007255 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 637909007256 motif II; other site 637909007257 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 637909007258 N-acetyl-D-glucosamine binding site [chemical binding]; other site 637909007259 catalytic residue [active] 637909007260 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 637909007261 ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619 637909007262 cobalt transporter ATP-binding subunit; Provisional; Region: cbiO; PRK13649 637909007263 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 637909007264 Walker A/P-loop; other site 637909007265 ATP binding site [chemical binding]; other site 637909007266 Q-loop/lid; other site 637909007267 ABC transporter signature motif; other site 637909007268 Walker B; other site 637909007269 D-loop; other site 637909007270 H-loop/switch region; other site 637909007271 cobalt transporter ATP-binding subunit; Provisional; Region: cbiO; PRK13650 637909007272 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 637909007273 Walker A/P-loop; other site 637909007274 ATP binding site [chemical binding]; other site 637909007275 Q-loop/lid; other site 637909007276 ABC transporter signature motif; other site 637909007277 Walker B; other site 637909007278 D-loop; other site 637909007279 H-loop/switch region; other site 637909007280 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453 637909007281 Helix-turn-helix domain; Region: HTH_25; pfam13413 637909007282 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 637909007283 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 637909007284 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 637909007285 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 637909007286 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 637909007287 S4 domain protein YaaA; Region: YaaA_near_RecF; TIGR02988 637909007288 recombination protein F; Reviewed; Region: recF; PRK00064 637909007289 ATP-binding cassette domain of RecF; Region: ABC_RecF; cd03242 637909007290 Walker A/P-loop; other site 637909007291 ATP binding site [chemical binding]; other site 637909007292 Q-loop/lid; other site 637909007293 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 637909007294 ABC transporter signature motif; other site 637909007295 Walker B; other site 637909007296 D-loop; other site 637909007297 H-loop/switch region; other site 637909007298 Putative glucose uptake permease [Carbohydrate transport and metabolism]; Region: GlcU; COG4975 637909007299 inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567 637909007300 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 637909007301 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein. IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a...; Region: CBS_pair_IMPDH; cd04601 637909007302 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 637909007303 active site 637909007304 tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282 637909007305 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 637909007306 active site 637909007307 HIGH motif; other site 637909007308 dimer interface [polypeptide binding]; other site 637909007309 KMSKS motif; other site 637909007310 Uncharacterized conserved protein [Function unknown]; Region: COG1284 637909007311 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 637909007312 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 637909007313 ABC transporter ATP-binding protein; Provisional; Region: PRK15064 637909007314 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 637909007315 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 637909007316 ABC transporter; Region: ABC_tran_2; pfam12848 637909007317 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 637909007318 Predicted membrane protein [Function unknown]; Region: COG4485 637909007319 rRNA large subunit methyltransferase; Provisional; Region: PRK00103 637909007320 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 637909007321 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 637909007322 protein binding site [polypeptide binding]; other site 637909007323 ParB/RepB/Spo0J family partition protein; Region: parB_part; TIGR00180 637909007324 ParB-like nuclease domain; Region: ParBc; pfam02195