-- dump date   	20140620_082207
-- class       	Genbank::misc_feature
-- table       	misc_feature_note
-- id	note
467705000001	chromosomal replication initiation protein; Reviewed; Region: dnaA; PRK00149
467705000002	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
467705000003	Walker A motif; other site
467705000004	ATP binding site [chemical binding]; other site
467705000005	Walker B motif; other site
467705000006	arginine finger; other site
467705000007	C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571
467705000008	DnaA box-binding interface [nucleotide binding]; other site
467705000009	DNA polymerase III subunit beta; Validated; Region: PRK05643
467705000010	Beta clamp domain.  The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria.  The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140
467705000011	putative DNA binding surface [nucleotide binding]; other site
467705000012	dimer interface [polypeptide binding]; other site
467705000013	beta-clamp/clamp loader binding surface; other site
467705000014	beta-clamp/translesion DNA polymerase binding surface; other site
467705000015	Bacterial protein of unknown function (DUF951); Region: DUF951; pfam06107
467705000016	Protein of unknown function (DUF1307); Region: DUF1307; pfam06998
467705000017	Predicted membrane protein [Function unknown]; Region: COG4485
467705000018	ABC transporter ATP-binding protein; Provisional; Region: PRK15064
467705000019	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
467705000020	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
467705000021	ABC transporter; Region: ABC_tran_2; pfam12848
467705000022	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
467705000023	tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282
467705000024	catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806
467705000025	active site
467705000026	HIGH motif; other site
467705000027	dimer interface [polypeptide binding]; other site
467705000028	KMSKS motif; other site
467705000029	inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567
467705000030	TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186
467705000031	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein.  IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a...; Region: CBS_pair_IMPDH; cd04601
467705000032	IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381
467705000033	active site
467705000034	recombination protein F; Reviewed; Region: recF; PRK00064
467705000035	ATP-binding cassette domain of RecF; Region: ABC_RecF; cd03242
467705000036	Walker A/P-loop; other site
467705000037	ATP binding site [chemical binding]; other site
467705000038	Q-loop/lid; other site
467705000039	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
467705000040	ABC transporter signature motif; other site
467705000041	Walker B; other site
467705000042	D-loop; other site
467705000043	H-loop/switch region; other site
467705000044	S4-like RNA binding protein [Replication, recombination, and repair]; Region: COG2501
467705000045	Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612
467705000046	Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193
467705000047	Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612
467705000048	Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675
467705000049	Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193
467705000050	Predicted transcriptional regulator contains Xre-like HTH domain [Function unknown]; Region: COG1426
467705000051	Helix-turn-helix domain; Region: HTH_25; pfam13413
467705000052	CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453
467705000053	cobalt transporter ATP-binding subunit; Provisional; Region: cbiO; PRK13650
467705000054	First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225
467705000055	Walker A/P-loop; other site
467705000056	ATP binding site [chemical binding]; other site
467705000057	Q-loop/lid; other site
467705000058	ABC transporter signature motif; other site
467705000059	Walker B; other site
467705000060	D-loop; other site
467705000061	H-loop/switch region; other site
467705000062	cobalt transporter ATP-binding subunit; Provisional; Region: cbiO; PRK13649
467705000063	First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225
467705000064	Walker A/P-loop; other site
467705000065	ATP binding site [chemical binding]; other site
467705000066	Q-loop/lid; other site
467705000067	ABC transporter signature motif; other site
467705000068	Walker B; other site
467705000069	D-loop; other site
467705000070	H-loop/switch region; other site
467705000071	ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619
467705000072	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
467705000073	Transglycosylase-like domain; Region: Transglycosylas; pfam06737
467705000074	Serine dehydratase alpha chain; Region: SDH_alpha; cl12120
467705000075	L-serine deaminase [Amino acid transport and metabolism]; Region: SdaA; COG1760
467705000076	L-serine dehydratase, iron-sulfur-dependent, beta subunit; Region: sda_beta; TIGR00719
467705000077	Serine dehydratase beta chain; Region: SDH_beta; pfam03315
467705000078	C-terminal ACT domain of the L-serine dehydratase (LSD), iron-sulfur-dependent, beta subunit; Region: ACT_LSD; cd04903
467705000079	putative L-serine binding site [chemical binding]; other site
467705000080	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
467705000081	Predicted tRNA(5-methylaminomethyl-2-thiouridylate) methyltransferase, contains the PP-loop ATPase domain [Translation, ribosomal structure and biogenesis]; Region: TrmU; COG0482
467705000082	tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998
467705000083	Multiple antibiotic transporter [Intracellular trafficking and secretion]; Region: MarC; COG2095
467705000084	tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA; Validated; Region: PRK05192
467705000085	NAD(FAD)-utilizing enzyme possibly involved in translation [Translation, ribosomal structure and biogenesis]; Region: Gid; COG1206
467705000086	GidA associated domain 3; Region: GIDA_assoc_3; pfam13932
467705000087	Predicted signaling protein consisting of a modified GGDEF domain and a DHH domain [Signal transduction mechanisms]; Region: COG3887
467705000088	DHH family; Region: DHH; pfam01368
467705000089	DHHA1 domain; Region: DHHA1; pfam02272
467705000090	50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137
467705000091	Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281
467705000092	Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948
467705000093	replicative DNA helicase; Provisional; Region: PRK05748
467705000094	DnaB-like helicase N terminal domain; Region: DnaB; pfam00772
467705000095	DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the  chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984
467705000096	Walker A motif; other site
467705000097	ATP binding site [chemical binding]; other site
467705000098	Walker B motif; other site
467705000099	DNA binding loops [nucleotide binding]
467705000100	Uncharacterized protein conserved in bacteria [Function unknown]; Region: Veg; COG4466
467705000101	aromatic amino acid aminotransferase; Validated; Region: PRK07309
467705000102	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
467705000103	pyridoxal 5'-phosphate binding site [chemical binding]; other site
467705000104	homodimer interface [polypeptide binding]; other site
467705000105	catalytic residue [active]
467705000106	DNA repair protein RecO; Reviewed; Region: recO; PRK00085
467705000107	Recombination protein O N terminal; Region: RecO_N; pfam11967
467705000108	Recombination protein O C terminal; Region: RecO_C; pfam02565
467705000109	putative phosphate acyltransferase; Provisional; Region: PRK05331
467705000110	acyl carrier protein; Provisional; Region: acpP; PRK00982
467705000111	phosphoribosylaminoimidazole-succinocarboxamide synthase; Reviewed; Region: PRK09362
467705000112	bacterial and archaeal 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_PurC; cd01415
467705000113	ATP binding site [chemical binding]; other site
467705000114	active site
467705000115	substrate binding site [chemical binding]; other site
467705000116	phosphoribosylformylglycinamidine synthase, clade II; Region: FGAM-synthase; TIGR01857
467705000117	AIR (aminoimidazole ribonucleotide) synthase related protein. This family includes Hydrogen expression/formation protein HypE, AIR synthases, FGAM (formylglycinamidine ribonucleotide) synthase and Selenophosphate synthetase (SelD). The N-terminal domain...; Region: PurM-like; cl10019
467705000118	PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203
467705000119	dimerization interface [polypeptide binding]; other site
467705000120	ATP binding site [chemical binding]; other site
467705000121	PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat2; cd02204
467705000122	dimerization interface [polypeptide binding]; other site
467705000123	ATP binding site [chemical binding]; other site
467705000124	Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740
467705000125	putative active site [active]
467705000126	catalytic triad [active]
467705000127	amidophosphoribosyltransferase; Provisional; Region: PRK07272
467705000128	Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of  glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715
467705000129	active site
467705000130	tetramer interface [polypeptide binding]; other site
467705000131	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
467705000132	active site
467705000133	phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385
467705000134	PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196
467705000135	dimerization interface [polypeptide binding]; other site
467705000136	putative ATP binding site [chemical binding]; other site
467705000137	phosphoribosylglycinamide formyltransferase; Reviewed; Region: purN; PRK05647
467705000138	Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645
467705000139	active site
467705000140	substrate binding site [chemical binding]; other site
467705000141	cosubstrate binding site; other site
467705000142	catalytic site [active]
467705000143	bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881
467705000144	Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal  ATIC formylase domain that formylates...; Region: IMPCH; cd01421
467705000145	purine monophosphate binding site [chemical binding]; other site
467705000146	dimer interface [polypeptide binding]; other site
467705000147	putative catalytic residues [active]
467705000148	AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; smart00798
467705000149	AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; cl03362
467705000150	Transcriptional regulators [Transcription]; Region: PhnF; COG2188
467705000151	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
467705000152	DNA-binding site [nucleotide binding]; DNA binding site
467705000153	The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; Region: UTRA; smart00866
467705000154	Beta-galactosidase [Carbohydrate transport and metabolism]; Region: LacA; COG1874
467705000155	Glycosyl hydrolases family 35; Region: Glyco_hydro_35; pfam01301
467705000156	Beta-galactosidase jelly roll domain; Region: BetaGal_dom4_5; pfam13364
467705000157	PTS_IIB, PTS system, Mannose/sorbose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_man; cd00001
467705000158	active site
467705000159	phosphorylation site [posttranslational modification]
467705000160	Phosphotransferase system, mannose/fructose/N-acetylgalactosamine-specific component IIC [Carbohydrate transport and metabolism]; Region: ManY; COG3715
467705000161	PTS system mannose/fructose/sorbose family IID component; Region: EIID-AGA; pfam03613
467705000162	PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006
467705000163	active pocket/dimerization site; other site
467705000164	active site
467705000165	phosphorylation site [posttranslational modification]
467705000166	putative sugar isomerase, AgaS family; Region: agaS_fam; TIGR02815
467705000167	SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008
467705000168	dimer interface [polypeptide binding]; other site
467705000169	active site
467705000170	AgaS-like protein. AgaS contains a SIS (Sugar ISomerase) domain which is found in many phosphosugar isomerases and phosphosugar binding proteins. AgaS is a putative isomerase in Escherichia coli. It is similar to the glucosamine-6-phosphate synthases; Region: SIS_AgaS_like; cd05010
467705000171	putative active site [active]
467705000172	galactose mutarotase_like; Region: galactose_mutarotase_like; cd09019
467705000173	active site
467705000174	catalytic residues [active]
467705000175	Domain of unknown function (DUF4097); Region: DUF4097; pfam13349
467705000176	Domain of unknown function (DUF4098); Region: DUF4098; pfam13345
467705000177	Domain of unknown function (DUF4098); Region: DUF4098; pfam13345
467705000178	Predicted membrane protein [Function unknown]; Region: COG4709
467705000179	Predicted transcriptional regulators [Transcription]; Region: COG1695
467705000180	Transcriptional regulator PadR-like family; Region: PadR; pfam03551
467705000181	D-Ala-teichoic acid biosynthesis protein; Region: DUF3687; pfam12459
467705000182	D-alanine--poly(phosphoribitol) ligase subunit 1; Provisional; Region: PRK04813
467705000183	D-alanine:D-alanyl carrier protein ligase (DltA); Region: DltA; cd05945
467705000184	acyl-activating enzyme (AAE) consensus motif; other site
467705000185	AMP binding site [chemical binding]; other site
467705000186	D-alanyl-lipoteichoic acid biosynthesis protein DltB; Region: LTA_dltB; TIGR04091
467705000187	D-alanine--poly(phosphoribitol) ligase subunit 2; Validated; Region: PRK05087
467705000188	Protein involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein) [Cell envelope biogenesis, outer membrane]; Region: DltD; COG3966
467705000189	DltD N-terminal region; Region: DltD_N; pfam04915
467705000190	DltD central region; Region: DltD_M; pfam04918
467705000191	DltD C-terminal region; Region: DltD_C; pfam04914
467705000192	Acetyltransferase (GNAT) domain; Region: Acetyltransf_8; pfam13523
467705000193	WXG100 family type VII secretion target; Region: WXG100_ESAT6; TIGR03930
467705000194	type VII secretion protein EsaA, N-terminal domain; Region: T7_esaA_Nterm; TIGR03929
467705000195	YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061
467705000196	type VII secretion protein EssA; Region: T7SS_EssA_Firm; TIGR03927
467705000197	WXG100 protein secretion system (Wss), protein YukD; Region: YukD; cl17489
467705000198	type VII secretion protein EssB; Region: T7_EssB; TIGR03926
467705000199	WXG100 protein secretion system (Wss), protein YukC; Region: YukC; pfam10140
467705000200	DNA transporter; Region: FtsK_SpoIIIE_N; pfam12538
467705000201	type VII secretion protein EssC, C-terminal domain; Region: T7_EssCb_Firm; TIGR03928
467705000202	FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580
467705000203	FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580
467705000204	Domain of unknown function (DUF4176); Region: DUF4176; pfam13780
467705000205	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
467705000206	haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282
467705000207	active site
467705000208	motif I; other site
467705000209	motif II; other site
467705000210	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
467705000211	Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349
467705000212	DeoR-like helix-turn-helix domain; Region: HTH_DeoR; cl17531
467705000213	DeoR C terminal sensor domain; Region: DeoRC; pfam00455
467705000214	Cyanate permease [Inorganic ion transport and metabolism]; Region: CynX; COG2807
467705000215	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
467705000216	putative substrate translocation pore; other site
467705000217	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
467705000218	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
467705000219	Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]; Region: CzcD; COG1230
467705000220	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
467705000221	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
467705000222	Predicted membrane protein [Function unknown]; Region: COG1511
467705000223	YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061
467705000224	YhgE/Pip C-terminal domain; Region: pip_yhgE_Cterm; TIGR03062
467705000225	Polyphosphate(polyP) polymerase domain of yeast vacuolar transport chaperone (VTC) proteins VTC-2, -3 and- 4, and similar proteins; Region: PolyPPase_VTC_like; cd07750
467705000226	putative metal binding residues [ion binding]; other site
467705000227	signature motif; other site
467705000228	dimer interface [polypeptide binding]; other site
467705000229	active site
467705000230	polyP binding site; other site
467705000231	substrate binding site [chemical binding]; other site
467705000232	acceptor-phosphate pocket; other site
467705000233	Domain of unknown function (DUF4353); Region: DUF4353; pfam14262
467705000234	Microcin C7 self-immunity protein determines resistance to exogenous microcin C7; Region: Peptidase_S66_mccF_like; cd07062
467705000235	putative dimer interface [polypeptide binding]; other site
467705000236	catalytic triad [active]
467705000237	Predicted hydrolase (HAD superfamily) [General function prediction only]; Region: COG1011
467705000238	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
467705000239	motif II; other site
467705000240	NrdI Flavodoxin like; Region: Flavodoxin_NdrI; cl17293
467705000241	Early set domain associated with the catalytic domain of pullulanase (also called dextrinase and alpha-dextrin endo-1,6-alpha glucosidase); Region: E_set_Pullulanase; cd02860
467705000242	Alpha amylase catalytic domain found in Pullulanase (also called dextrinase; alpha-dextrin endo-1,6-alpha glucosidase), limit dextrinase, and related proteins; Region: AmyAc_Pullulanase_LD-like; cd11341
467705000243	Ca binding site [ion binding]; other site
467705000244	active site
467705000245	catalytic site [active]
467705000246	Transcriptional regulators [Transcription]; Region: PurR; COG1609
467705000247	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
467705000248	DNA binding site [nucleotide binding]
467705000249	domain linker motif; other site
467705000250	Ligand-binding domain of uncharacterized transcription regulator ycjW which is a member of the LacI-GalR family repressors; Region: PBP1_ycjW_transcription_regulator_like; cd06294
467705000251	putative dimerization interface [polypeptide binding]; other site
467705000252	putative ligand binding site [chemical binding]; other site
467705000253	Predicted integral membrane protein [Function unknown]; Region: COG5521
467705000254	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
467705000255	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
467705000256	dimer interface [polypeptide binding]; other site
467705000257	conserved gate region; other site
467705000258	putative PBP binding loops; other site
467705000259	ABC-ATPase subunit interface; other site
467705000260	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
467705000261	dimer interface [polypeptide binding]; other site
467705000262	conserved gate region; other site
467705000263	putative PBP binding loops; other site
467705000264	ABC-ATPase subunit interface; other site
467705000265	Maltose-binding periplasmic proteins/domains [Carbohydrate transport and metabolism]; Region: MalE; COG2182
467705000266	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
467705000267	4-alpha-glucanotransferase; Provisional; Region: PRK14508
467705000268	glycogen/starch/alpha-glucan phosphorylases; Region: P_ylase; TIGR02093
467705000269	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
467705000270	Collagen binding domain; Region: Collagen_bind; pfam05737
467705000271	streptococcal pilin isopeptide linkage domain; Region: strep_pil_rpt; TIGR03786
467705000272	streptococcal pilin isopeptide linkage domain; Region: strep_pil_rpt; TIGR03786
467705000273	streptococcal pilin isopeptide linkage domain; Region: strep_pil_rpt; TIGR03786
467705000274	streptococcal pilin isopeptide linkage domain; Region: strep_pil_rpt; TIGR03786
467705000275	streptococcal pilin isopeptide linkage domain; Region: strep_pil_rpt; TIGR03786
467705000276	streptococcal pilin isopeptide linkage domain; Region: strep_pil_rpt; TIGR03786
467705000277	Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080
467705000278	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
467705000279	Walker A motif; other site
467705000280	ATP binding site [chemical binding]; other site
467705000281	Walker B motif; other site
467705000282	arginine finger; other site
467705000283	Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491
467705000284	Bacterial protein of unknown function (DUF925); Region: DUF925; pfam06042
467705000285	Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394
467705000286	Low molecular weight phosphatase family; Region: LMWPc; cd00115
467705000287	active site
467705000288	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4642
467705000289	MORN repeat; Region: MORN; cl14787
467705000290	MORN repeat; Region: MORN; cl14787
467705000291	Predicted acyltransferases [Lipid metabolism]; Region: COG1835
467705000292	SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053
467705000293	active site
467705000294	catalytic triad [active]
467705000295	oxyanion hole [active]
467705000296	bifunctional acetaldehyde-CoA/alcohol dehydrogenase; Provisional; Region: PRK13805
467705000297	Coenzyme A acylating aldehyde dehydrogenase (ACDH), ALDH family 20-like; Region: ALDH_F20_ACDH; cd07122
467705000298	putative catalytic cysteine [active]
467705000299	C-terminal alcohol dehydrogenase domain of the acetaldehyde dehydrogenase-alcohol dehydrogenase bifunctional two-domain protein (AAD); Region: AAD_C; cd08178
467705000300	putative active site [active]
467705000301	metal binding site [ion binding]; metal-binding site
467705000302	class IIb bacteriocin, lactobin A/cerein 7B family; Region: bact_IIb_cerein; TIGR03949
467705000303	N-acetylmannosamine-6-phosphate epimerase (NanE) converts N-acetylmannosamine-6-phosphate to N-acetylglucosamine-6-phosphate. This reaction is part of the pathway that allows the usage of sialic acid as a carbohydrate source. Sialic acids are a family of...; Region: NanE; cd04729
467705000304	N-acetylmannosamine-6-phosphate 2-epimerase; Provisional; Region: PRK01130
467705000305	putative active site cavity [active]
467705000306	Domain of unknown function (DUF386); Region: DUF386; pfam04074
467705000307	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
467705000308	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
467705000309	ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177
467705000310	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
467705000311	dimer interface [polypeptide binding]; other site
467705000312	conserved gate region; other site
467705000313	putative PBP binding loops; other site
467705000314	ABC-ATPase subunit interface; other site
467705000315	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
467705000316	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
467705000317	dimer interface [polypeptide binding]; other site
467705000318	conserved gate region; other site
467705000319	putative PBP binding loops; other site
467705000320	ABC-ATPase subunit interface; other site
467705000321	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
467705000322	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
467705000323	Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894
467705000324	Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329
467705000325	Class I aldolases; Region: Aldolase_Class_I; cl17187
467705000326	catalytic residue [active]
467705000327	Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940
467705000328	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012
467705000329	nucleotide binding site [chemical binding]; other site
467705000330	Transcriptional regulators [Transcription]; Region: RpiR; COG1737
467705000331	Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418
467705000332	RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013
467705000333	putative active site [active]
467705000334	Archaeal/vacuolar-type H+-ATPase subunit I [Energy production and conversion]; Region: NtpI; COG1269
467705000335	V-type ATP synthase subunit K; Validated; Region: PRK06558
467705000336	ATP synthase subunit C; Region: ATP-synt_C; pfam00137
467705000337	ATP synthase subunit C; Region: ATP-synt_C; pfam00137
467705000338	V-type ATP synthase subunit E; Provisional; Region: PRK02292
467705000339	Archaeal/vacuolar-type H+-ATPase subunit C [Energy production and conversion]; Region: NtpC; COG1527
467705000340	V-type ATP synthase subunit C; Provisional; Region: PRK01198; cl00660
467705000341	V-type ATP synthase subunit F; Provisional; Region: PRK01395
467705000342	Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670
467705000343	Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583
467705000344	V-type ATP synthase subunit A; Provisional; Region: PRK04192
467705000345	ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874
467705000346	V/A-type ATP synthase catalytic subunit A. These ATPases couple ATP hydrolysis to the build up of a H+ gradient, but V-type ATPases do not catalyze the reverse reaction.  The Vacuolar (V-type) ATPase is found in the membranes of vacuoles, the golgi...; Region: V_A-ATPase_A; cd01134
467705000347	Walker A motif/ATP binding site; other site
467705000348	Walker B motif; other site
467705000349	ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306
467705000350	V-type ATP synthase subunit B; Provisional; Region: PRK04196
467705000351	ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874
467705000352	V/A-type ATP synthase (non-catalytic) subunit B. These ATPases couple ATP hydrolysis to the build up of a H+ gradient, but V-type ATPases do not catalyze the reverse reaction. The Vacuolar (V-type) ATPase is found in the membranes of vacuoles, the golgi...; Region: V_A-ATPase_B; cd01135
467705000353	Walker A motif homologous position; other site
467705000354	Walker B motif; other site
467705000355	ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306
467705000356	V-type ATP synthase subunit D; Reviewed; Region: PRK00373
467705000357	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
467705000358	Threonine synthase catalyzes the final step of threonine biosynthesis. The conversion of O-phosphohomoserine into threonine and inorganic phosphate is pyridoxal 5'-phosphate dependent. The Thr-synth_1 CD includes members from higher plants; Region: Thr-synth_2; cd01560
467705000359	Threonine synthase [Amino acid transport and metabolism]; Region: ThrC; COG0498
467705000360	pyridoxal 5'-phosphate binding site [chemical binding]; other site
467705000361	catalytic residue [active]
467705000362	Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534
467705000363	Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Thermotoga marina NorM; Region: MATE_NorM_like; cd13137
467705000364	Haloacid dehalogenase-like hydrolase; Region: HAD_2; pfam13419
467705000365	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
467705000366	motif II; other site
467705000367	YcxB-like protein; Region: YcxB; pfam14317
467705000368	DNA polymerase I; Provisional; Region: PRK05755
467705000369	PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859
467705000370	active site
467705000371	metal binding site 1 [ion binding]; metal-binding site
467705000372	putative 5' ssDNA interaction site; other site
467705000373	metal binding site 3; metal-binding site
467705000374	metal binding site 2 [ion binding]; metal-binding site
467705000375	H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898
467705000376	putative DNA binding site [nucleotide binding]; other site
467705000377	putative metal binding site [ion binding]; other site
467705000378	inactive DEDDy 3'-5' exonuclease domain of Bacillus stearothermophilus DNA polymerase I and similar family-A DNA polymerases; Region: DNA_polA_I_Bacillus_like_exo; cd06140
467705000379	Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637
467705000380	active site
467705000381	DNA binding site [nucleotide binding]
467705000382	catalytic site [active]
467705000383	Predicted CoA-binding protein [General function prediction only]; Region: COG1832
467705000384	hypothetical protein; Provisional; Region: PRK06762
467705000385	Alpha-L-fucosidase; Region: Alpha_L_fucos; smart00812
467705000386	Alpha-L-fucosidase [Carbohydrate transport and metabolism]; Region: COG3669
467705000387	Protein of unknown function (DUF975); Region: DUF975; cl10504
467705000388	queuine tRNA-ribosyltransferase; Provisional; Region: tgt; PRK00112
467705000389	Queuine/archaeosine tRNA-ribosyltransferase [Translation, ribosomal structure and biogenesis]; Region: Tgt; COG0343
467705000390	Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285
467705000391	nucleoside/Zn binding site; other site
467705000392	dimer interface [polypeptide binding]; other site
467705000393	catalytic motif [active]
467705000394	glucose-6-phosphate isomerase; Provisional; Region: pgi; PRK14097
467705000395	Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015
467705000396	active site
467705000397	dimer interface [polypeptide binding]; other site
467705000398	Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016
467705000399	dimer interface [polypeptide binding]; other site
467705000400	active site
467705000401	Tetrahydrodipicolinate succinyltransferase N-terminal; Region: DapH_N; pfam08503
467705000402	2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-acetyltransferase; Region: DapD_Ac; TIGR03532
467705000403	2,3,4,5-tetrahydropyridine-2,6-dicarboxylate (THDP) N-succinyltransferase (also called THP succinyltransferase): THDP N-succinyltransferase catalyzes the conversion of tetrahydrodipicolinate and succinyl-CoA to N-succinyltetrahydrodipicolinate and CoA; Region: LbH_THP_succinylT; cd03350
467705000404	trimer interface [polypeptide binding]; other site
467705000405	active site
467705000406	substrate binding site [chemical binding]; other site
467705000407	CoA binding site [chemical binding]; other site
467705000408	M20 Peptidase Aminoacyclase-1 YkuR-like proteins, including YkuR and Ama/HipO/HyuC proteins; Region: M20_Acy1_YkuR_like; cd05670
467705000409	Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473
467705000410	metal binding site [ion binding]; metal-binding site
467705000411	putative dimer interface [polypeptide binding]; other site
467705000412	5-formyltetrahydrofolate cyclo-ligase family; Region: 5-FTHF_cyc-lig; pfam01812
467705000413	5,10-methenyltetrahydrofolate synthetase; Region: MTHFS_bact; TIGR02727
467705000414	Membrane associated serine protease [Amino acid transport and metabolism]; Region: COG0705
467705000415	Peptidase family C69; Region: Peptidase_C69; pfam03577
467705000416	Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541
467705000417	dTDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: RfbA; COG1209
467705000418	active site
467705000419	tetramer interface; other site
467705000420	NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094
467705000421	NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210
467705000422	NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479
467705000423	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
467705000424	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
467705000425	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
467705000426	Walker A/P-loop; other site
467705000427	ATP binding site [chemical binding]; other site
467705000428	Q-loop/lid; other site
467705000429	ABC transporter signature motif; other site
467705000430	Walker B; other site
467705000431	D-loop; other site
467705000432	H-loop/switch region; other site
467705000433	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
467705000434	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
467705000435	ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251
467705000436	Walker A/P-loop; other site
467705000437	ATP binding site [chemical binding]; other site
467705000438	Q-loop/lid; other site
467705000439	ABC transporter signature motif; other site
467705000440	Walker B; other site
467705000441	D-loop; other site
467705000442	H-loop/switch region; other site
467705000443	Predicted glutamine amidotransferases [General function prediction only]; Region: COG2071
467705000444	Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_2; cd01745
467705000445	catalytic triad [active]
467705000446	MutT homolog-1 (MTH1) is a member of the Nudix hydrolase superfamily. MTH1, the mammalian counterpart of MutT, hydrolyzes oxidized purine nucleoside triphosphates, such as 8-oxo-dGTP and 2-hydroxy-ATP, to monophosphates, thereby preventing the...; Region: MTH1; cd03427
467705000447	putative active site [active]
467705000448	nucleotide binding site [chemical binding]; other site
467705000449	nudix motif; other site
467705000450	putative metal binding site [ion binding]; other site
467705000451	Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557
467705000452	trimer interface [polypeptide binding]; other site
467705000453	active site
467705000454	Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431
467705000455	catalytic triad [active]
467705000456	conserved cis-peptide bond; other site
467705000457	DNA repair protein RadA; Provisional; Region: PRK11823
467705000458	Sms (bacterial radA) DNA repair protein. This protein is not related to archael radA any more than is to other RecA-like NTPases. Sms has a role in recombination and recombinational repair and is responsible for the stabilization or processing of...; Region: Sms; cd01121
467705000459	Walker A motif/ATP binding site; other site
467705000460	ATP binding site [chemical binding]; other site
467705000461	Walker B motif; other site
467705000462	Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541
467705000463	Mitochondrial biogenesis AIM24; Region: AIM24; pfam01987
467705000464	Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeD; cd03379
467705000465	active site clefts [active]
467705000466	zinc binding site [ion binding]; other site
467705000467	dimer interface [polypeptide binding]; other site
467705000468	glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406
467705000469	catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808
467705000470	active site
467705000471	HIGH motif; other site
467705000472	catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808
467705000473	active site
467705000474	KMSKS motif; other site
467705000475	PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cl00025
467705000476	argininosuccinate synthase; Provisional; Region: PRK13820
467705000477	Argininosuccinate synthase. The Argininosuccinate synthase is a urea cycle enzyme that catalyzes the penultimate step in arginine biosynthesis: the ATP-dependent ligation of citrulline to aspartate to form argininosuccinate, AMP and pyrophosphate .  In...; Region: Argininosuccinate_Synthase; cd01999
467705000478	ANP binding site [chemical binding]; other site
467705000479	Substrate Binding Site II [chemical binding]; other site
467705000480	Substrate Binding Site I [chemical binding]; other site
467705000481	argininosuccinate lyase; Provisional; Region: PRK00855
467705000482	Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359
467705000483	active sites [active]
467705000484	tetramer interface [polypeptide binding]; other site
467705000485	ribonuclease P; Reviewed; Region: rnpA; PRK00499
467705000486	Preprotein translocase subunit YidC [Intracellular trafficking and secretion]; Region: YidC; COG0706
467705000487	membrane protein insertase, YidC/Oxa1 family, C-terminal domain; Region: yidC_oxa1_cterm; TIGR03592
467705000488	Predicted RNA-binding protein [General function prediction only]; Region: Jag; COG1847
467705000489	jag_K homology RNA-binding domain. The KH domain is found in proteins homologous to the Bacillus subtilis protein Jag, which is associated with SpoIIIJ and is necessary for the third stage of sporulation.  The KH motif is a beta-alpha-alpha-beta-beta...; Region: jag_KH; cd02414
467705000490	G-X-X-G motif; other site
467705000491	R3H domain found in proteins homologous to Bacillus subtilus Jag, which is associated with SpoIIIJ. SpoIIIJ is necessary for the third stage of sporulation. The name of the R3H domain comes from the characteristic spacing of the most conserved arginine...; Region: R3H_jag; cd02644
467705000492	RxxxH motif; other site
467705000493	Ribosomal protein L34; Region: Ribosomal_L34; cl00370
467705000494	Predicted transcriptional regulator [Transcription]; Region: COG3655
467705000495	TatD like proteins;  E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310
467705000496	Predicted metal-dependent hydrolases with the TIM-barrel fold [General function prediction only]; Region: COG1099
467705000497	active site
467705000498	ribonuclease M5; Region: 5S_RNA_mat_M5; TIGR00334
467705000499	TOPRIM_ RNase M5_like: The topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain found in Ribonuclease M5: (RNase M5) and other small primase-like proteins from bacteria and archaea.  RNase M5 catalyzes the maturation of 5S rRNA in low...; Region: TOPRIM_RNase_M5_like; cd01027
467705000500	putative active site [active]
467705000501	putative metal binding site [ion binding]; other site
467705000502	Domain of unknown function (DUF4093); Region: DUF4093; pfam13331
467705000503	short chain dehydrogenase; Provisional; Region: PRK06197
467705000504	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
467705000505	NAD(P) binding site [chemical binding]; other site
467705000506	active site
467705000507	16S ribosomal RNA methyltransferase KsgA/Dim1 family protein; Reviewed; Region: ksgA; PRK00274
467705000508	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
467705000509	S-adenosylmethionine binding site [chemical binding]; other site
467705000510	CAAX protease self-immunity; Region: Abi; pfam02517
467705000511	GTPase RsgA; Reviewed; Region: PRK00098
467705000512	S1_YloQ_GTPase: YloQ GTase family (also known as YjeQ and CpgA), S1-like RNA-binding domain. Proteins in the YloQ GTase family bind the ribosome and have GTPase activity. The precise role of this family is unknown. The protein structure is composed of...; Region: S1_YloQ_GTPase; cd04466
467705000513	RNA binding site [nucleotide binding]; other site
467705000514	homodimer interface [polypeptide binding]; other site
467705000515	Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854
467705000516	GTPase/Zn-binding domain interface [polypeptide binding]; other site
467705000517	GTP/Mg2+ binding site [chemical binding]; other site
467705000518	G4 box; other site
467705000519	G1 box; other site
467705000520	Switch I region; other site
467705000521	G2 box; other site
467705000522	G3 box; other site
467705000523	Switch II region; other site
467705000524	Pentose-5-phosphate-3-epimerase [Carbohydrate transport and metabolism]; Region: Rpe; COG0036
467705000525	Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429
467705000526	substrate binding site [chemical binding]; other site
467705000527	hexamer interface [polypeptide binding]; other site
467705000528	metal binding site [ion binding]; metal-binding site
467705000529	Thiamine pyrophosphokinase [Coenzyme metabolism]; Region: THI80; COG1564
467705000530	Thiamine pyrophosphokinase; Region: TPK; cd07995
467705000531	active site
467705000532	dimerization interface [polypeptide binding]; other site
467705000533	thiamine binding site [chemical binding]; other site
467705000534	Predicted nuclease of restriction endonuclease-like fold, RmuC family [General function prediction only]; Region: COG1322
467705000535	RmuC family; Region: RmuC; pfam02646
467705000536	Predicted HD-superfamily hydrolase [General function prediction only]; Region: COG3481
467705000537	YhaM_OBF_like: A subfamily of OB folds similar to that found in Bacillus subtilis YhaM and Staphylococcus aureus cmp-binding factor-1 (SaCBF1). Both these proteins are 3'-to-5'exoribonucleases. YhaM requires Mn2+ or Co2+ for activity and is...; Region: YhaM_OBF_like; cd04492
467705000538	generic binding surface II; other site
467705000539	generic binding surface I; other site
467705000540	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
467705000541	Zn2+ binding site [ion binding]; other site
467705000542	Mg2+ binding site [ion binding]; other site
467705000543	pur operon repressor; Provisional; Region: PRK09213
467705000544	Bacterial purine repressor, N-terminal; Region: PuR_N; pfam09182
467705000545	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
467705000546	active site
467705000547	S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368
467705000548	S17 interaction site [polypeptide binding]; other site
467705000549	S8 interaction site; other site
467705000550	16S rRNA interaction site [nucleotide binding]; other site
467705000551	streptomycin interaction site [chemical binding]; other site
467705000552	23S rRNA interaction site [nucleotide binding]; other site
467705000553	aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site
467705000554	30S ribosomal protein S7; Validated; Region: PRK05302
467705000555	elongation factor G; Reviewed; Region: PRK00007
467705000556	Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886
467705000557	G1 box; other site
467705000558	putative GEF interaction site [polypeptide binding]; other site
467705000559	GTP/Mg2+ binding site [chemical binding]; other site
467705000560	Switch I region; other site
467705000561	G2 box; other site
467705000562	G3 box; other site
467705000563	Switch II region; other site
467705000564	G4 box; other site
467705000565	G5 box; other site
467705000566	EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088
467705000567	EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434
467705000568	EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G.  Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713
467705000569	Glyceraldehyde-3-phosphate dehydrogenase/erythrose-4-phosphate dehydrogenase [Carbohydrate transport and metabolism]; Region: GapA; COG0057
467705000570	Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846
467705000571	Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800
467705000572	Gram-positive signal peptide, YSIRK family; Region: YSIRK_signal; TIGR01168
467705000573	Endo-beta-N-acetylglucosaminidase D [Carbohydrate transport and metabolism]; Region: COG4724
467705000574	Glycosyl hydrolase family 85; Region: Glyco_hydro_85; pfam03644
467705000575	active site
467705000576	Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes; Region: FA58C; cl12042
467705000577	Bacterial Ig-like domain (group 3); Region: Big_3; pfam07523
467705000578	phosphoglycerate kinase; Provisional; Region: pgk; PRK00073
467705000579	Phosphoglycerate kinase; Region: PGK; pfam00162
467705000580	substrate binding site [chemical binding]; other site
467705000581	hinge regions; other site
467705000582	ADP binding site [chemical binding]; other site
467705000583	catalytic site [active]
467705000584	Domain of unknown function (DUF4337); Region: DUF4337; pfam14235
467705000585	Streptococcal surface antigen repeat; Region: Strep_SA_rep; pfam06696
467705000586	Streptococcal surface antigen repeat; Region: Strep_SA_rep; pfam06696
467705000587	Glucan-binding protein C; Region: GbpC; pfam08363
467705000588	adhesin isopeptide-forming domain, sspB-C2 type; Region: isopep_sspB_C2; TIGR04228
467705000589	Domain of unknown function (DUF4337); Region: DUF4337; pfam14235
467705000590	Tumour suppressor, Mitostatin; Region: Trichoplein; pfam13868
467705000591	Streptococcal surface antigen repeat; Region: Strep_SA_rep; pfam06696
467705000592	Streptococcal surface antigen repeat; Region: Strep_SA_rep; pfam06696
467705000593	Glucan-binding protein C; Region: GbpC; pfam08363
467705000594	adhesin isopeptide-forming domain, sspB-C2 type; Region: isopep_sspB_C2; TIGR04228
467705000595	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
467705000596	Surface antigen [General function prediction only]; Region: COG3942
467705000597	CHAP domain; Region: CHAP; pfam05257
467705000598	Predicted membrane protein [Function unknown]; Region: COG4129
467705000599	Bacterial protein of unknown function (DUF939); Region: DUF939; pfam06081
467705000600	Helix-Turn-Helix DNA binding domain of GlnR-like transcription regulators; Region: HTH_GlnR-like; cd01105
467705000601	MerR HTH family regulatory protein; Region: MerR_1; pfam13411
467705000602	DNA binding residues [nucleotide binding]
467705000603	putative dimer interface [polypeptide binding]; other site
467705000604	Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174
467705000605	Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951
467705000606	Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120
467705000607	manganese transport protein MntH; Reviewed; Region: PRK00701
467705000608	Natural resistance-associated macrophage protein; Region: Nramp; pfam01566
467705000609	mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595
467705000610	Metallo-beta-lactamase superfamily; Region: Lactamase_B; pfam00753
467705000611	RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521
467705000612	hypothetical protein; Provisional; Region: PRK13667
467705000613	tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725
467705000614	Glycoprotease family; Region: Peptidase_M22; pfam00814
467705000615	ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575
467705000616	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
467705000617	Coenzyme A binding pocket [chemical binding]; other site
467705000618	UGMP family protein; Validated; Region: PRK09604
467705000619	tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725
467705000620	Carbamoyltransferase; Region: CmcH_NodU; pfam02543
467705000621	Predicted branched-chain amino acid permease (azaleucine resistance) [Amino acid transport and metabolism]; Region: AzlC; COG1296
467705000622	Predicted membrane protein [Function unknown]; Region: COG4392
467705000623	Methyltransferase domain; Region: Methyltransf_31; pfam13847
467705000624	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
467705000625	S-adenosylmethionine binding site [chemical binding]; other site
467705000626	Helix-Turn-Helix DNA binding domain of the transcription regulators TipAL, Mta, and SkgA; Region: HTH_TipAL-Mta; cd01106
467705000627	DNA binding residues [nucleotide binding]
467705000628	MerR HTH family regulatory protein; Region: MerR_1; pfam13411
467705000629	dimer interface [polypeptide binding]; other site
467705000630	TipAS antibiotic-recognition domain; Region: TipAS; pfam07739
467705000631	HI0933-like protein; Region: HI0933_like; pfam03486
467705000632	hydroxyglutarate oxidase; Provisional; Region: PRK11728
467705000633	Chromate resistance exported protein; Region: Chrome_Resist; cl01744
467705000634	HTH domain; Region: HTH_11; cl17392
467705000635	Membrane domain of glycerophosphoryl diester phosphodiesterase; Region: GPDPase_memb; cl01974
467705000636	Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584
467705000637	Glycerophosphodiester phosphodiesterase domain of uncharacterized bacterial glycerophosphodiester phosphodiesterases; Region: GDPD_memb_like; cd08579
467705000638	putative active site [active]
467705000639	catalytic site [active]
467705000640	putative metal binding site [ion binding]; other site
467705000641	hypothetical protein; Validated; Region: PRK00153
467705000642	NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961
467705000643	x-prolyl-dipeptidyl aminopeptidase; Provisional; Region: PRK05371
467705000644	X-Prolyl dipeptidyl aminopeptidase PepX, N-terminal; Region: PepX_N; pfam09168
467705000645	X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain; Region: PepX_C; pfam08530
467705000646	Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cd00333
467705000647	amphipathic channel; other site
467705000648	Asn-Pro-Ala signature motifs; other site
467705000649	Short repeat of unknown function (DUF308); Region: DUF308; cl15828
467705000650	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632
467705000651	active site
467705000652	Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680
467705000653	Beta-lactamase; Region: Beta-lactamase; pfam00144
467705000654	Mevalonate kinase [Lipid metabolism]; Region: ERG12; COG1577
467705000655	GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288
467705000656	GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544
467705000657	diphosphomevalonate decarboxylase; Region: mevDPdecarb; TIGR01240
467705000658	diphosphomevalonate decarboxylase; Region: PLN02407
467705000659	Mevalonate kinase [Lipid metabolism]; Region: ERG12; COG1577
467705000660	GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288
467705000661	GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544
467705000662	isopentenyl pyrophosphate isomerase; Provisional; Region: PRK05437
467705000663	Isopentenyl-diphosphate:dimethylallyl diphosphate isomerase type 2 (IDI-2) FMN-binding domain. Two types of IDIs have been characterized at present. The long known IDI-1 is only dependent on divalent metals for activity, whereas IDI-2 requires a metal; Region: IDI-2_FMN; cd02811
467705000664	homotetramer interface [polypeptide binding]; other site
467705000665	FMN binding site [chemical binding]; other site
467705000666	homodimer contacts [polypeptide binding]; other site
467705000667	putative active site [active]
467705000668	putative substrate binding site [chemical binding]; other site
467705000669	Class II hydroxymethylglutaryl-coenzyme A (HMG-CoA) reductase (HMGR); Region: HMG-CoA_reductase_classII; cd00644
467705000670	homodimer interface [polypeptide binding]; other site
467705000671	catalytic residues [active]
467705000672	NAD binding site [chemical binding]; other site
467705000673	substrate binding pocket [chemical binding]; other site
467705000674	flexible flap; other site
467705000675	"initiating" condensing enzymes are a subclass of decarboxylating condensing enzymes, including beta-ketoacyl [ACP] synthase, type III and polyketide synthases, type III, which include chalcone synthase and related enzymes. They are...; Region: init_cond_enzymes; cd00827
467705000676	3-hydroxy-3-methylglutaryl CoA synthase, prokaryotic clade; Region: HMG-CoA-S_prok; TIGR01835
467705000677	dimer interface [polypeptide binding]; other site
467705000678	active site
467705000679	Protein of unknown function (DUF3815); Region: DUF3815; pfam12821
467705000680	Uncharacterized conserved protein [Function unknown]; Region: COG2966
467705000681	Protein of unknown function (DUF1212); Region: DUF1212; pfam06738
467705000682	Protein of unknown function (DUF3815); Region: DUF3815; cl01118
467705000683	formate acetyltransferase 1; Region: pyr_form_ly_1; TIGR01255
467705000684	Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939
467705000685	DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586
467705000686	active site
467705000687	DNA polymerase IV; Validated; Region: PRK02406
467705000688	DNA binding site [nucleotide binding]
467705000689	CAAX protease self-immunity; Region: Abi; pfam02517
467705000690	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
467705000691	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
467705000692	helicase, putative, RecD/TraA family; Region: recD_rel; TIGR01448
467705000693	AAA domain; Region: AAA_30; pfam13604
467705000694	Family description; Region: UvrD_C_2; pfam13538
467705000695	signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227
467705000696	The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530
467705000697	Catalytic site [active]
467705000698	The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530
467705000699	ribonuclease HIII; Provisional; Region: PRK00996
467705000700	Domain of unknown function (DUF3378); Region: DUF3378; pfam11858
467705000701	bacterial Ribonuclease HIII-like; Region: RNase_HII_bacteria_HIII_like; cd06590
467705000702	RNA/DNA hybrid binding site [nucleotide binding]; other site
467705000703	active site
467705000704	Uncharacterized membrane protein, required for colicin V production [General function prediction only]; Region: CvpA; COG1286
467705000705	Colicin V production protein; Region: Colicin_V; pfam02674
467705000706	recombination and DNA strand exchange inhibitor protein; Reviewed; Region: PRK00409
467705000707	MutS domain III; Region: MutS_III; pfam05192
467705000708	ATP-binding cassette domain of MutS2; Region: ABC_MutS2; cd03280
467705000709	Walker A/P-loop; other site
467705000710	ATP binding site [chemical binding]; other site
467705000711	Q-loop/lid; other site
467705000712	ABC transporter signature motif; other site
467705000713	Walker B; other site
467705000714	D-loop; other site
467705000715	H-loop/switch region; other site
467705000716	Smr domain; Region: Smr; pfam01713
467705000717	Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673
467705000718	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
467705000719	Coenzyme A binding pocket [chemical binding]; other site
467705000720	Peptidase family C69; Region: Peptidase_C69; pfam03577
467705000721	TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947
467705000722	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
467705000723	catalytic residues [active]
467705000724	Transcriptional regulator [Transcription]; Region: LysR; COG0583
467705000725	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
467705000726	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
467705000727	START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643
467705000728	hydrophobic ligand binding site; other site
467705000729	Amino acid permease; Region: AA_permease_2; pfam13520
467705000730	Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668
467705000731	Mechanosensitive ion channel; Region: MS_channel; pfam00924
467705000732	Domain of unknown function (DUF4352); Region: DUF4352; pfam11611
467705000733	serine/threonine transporter SstT; Provisional; Region: PRK13628
467705000734	Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301
467705000735	Predicted Zn-dependent protease (DUF2268); Region: DUF2268; pfam10026
467705000736	EXLDI protein; Region: EXLDI; TIGR04342
467705000737	NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604
467705000738	alcohol dehydrogenase and quinone reductase-like medium chain degydrogenases/reductases; Region: MDR_like_2; cd05289
467705000739	putative NAD(P) binding site [chemical binding]; other site
467705000740	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
467705000741	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
467705000742	Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673
467705000743	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
467705000744	Coenzyme A binding pocket [chemical binding]; other site
467705000745	glutamate dehydrogenase; Provisional; Region: PRK09414
467705000746	Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812
467705000747	NAD(P) binding domain of glutamate dehydrogenase, subgroup 2; Region: NAD_bind_2_Glu_DH; cd05313
467705000748	NAD(P) binding site [chemical binding]; other site
467705000749	dihydroorotate dehydrogenase (subfamily 1) family protein; Region: pyrD_sub1_fam; TIGR01037
467705000750	Dihydroorotate dehydrogenase (DHOD) class 1A FMN-binding domain. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine...; Region: DHOD_1A_like; cd04741
467705000751	active site
467705000752	FMN binding site [chemical binding]; other site
467705000753	substrate binding site [chemical binding]; other site
467705000754	catalytic residues [active]
467705000755	homodimer interface [polypeptide binding]; other site
467705000756	Peptide methionine sulfoxide reductase [Posttranslational modification, protein turnover, chaperones]; Region: MsrA; COG0225
467705000757	Conserved domain frequently associated with peptide methionine sulfoxide reductase [Posttranslational modification, protein turnover, chaperones]; Region: COG0229
467705000758	SelR domain; Region: SelR; pfam01641
467705000759	chlorohydrolase; Validated; Region: PRK06687
467705000760	TRZ/ATZ family contains enzymes from the atrazine degradation pathway and related hydrolases. Atrazine, a chlorinated herbizide, can be catabolized by a variety of different bacteria. The first three steps of the atrazine dehalogenation pathway are...; Region: ATZ_TRZ_like; cd01298
467705000761	active site
467705000762	putative substrate binding pocket [chemical binding]; other site
467705000763	PTS system, beta-glucoside-specific IIABC component; Region: PTS-II-ABC-beta; TIGR01995
467705000764	PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212
467705000765	active site turn [active]
467705000766	phosphorylation site [posttranslational modification]
467705000767	Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263
467705000768	PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_glc; cd00210
467705000769	HPr interaction site; other site
467705000770	glycerol kinase (GK) interaction site [polypeptide binding]; other site
467705000771	active site
467705000772	phosphorylation site [posttranslational modification]
467705000773	Bacterial capsule synthesis protein PGA_cap; Region: PGA_cap; smart00854
467705000774	CapA and related proteins, metallophosphatase domain; Region: MPP_CapA; cd07381
467705000775	putative active site [active]
467705000776	putative metal binding site [ion binding]; other site
467705000777	AraC-like ligand binding domain; Region: AraC_binding; pfam02311
467705000778	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
467705000779	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
467705000780	Beta-glucosidase/6-phospho-beta-glucosidase/beta- galactosidase [Carbohydrate transport and metabolism]; Region: BglB; COG2723
467705000781	beta-galactosidase; Region: BGL; TIGR03356
467705000782	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
467705000783	Walker A/P-loop; other site
467705000784	ATP binding site [chemical binding]; other site
467705000785	Q-loop/lid; other site
467705000786	ABC transporter signature motif; other site
467705000787	Walker B; other site
467705000788	D-loop; other site
467705000789	H-loop/switch region; other site
467705000790	haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282
467705000791	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
467705000792	NnaC (CMP-NeuNAc synthetase) _like subfamily of SGNH_hydrolases, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its...; Region: NnaC_like; cd01841
467705000793	active site
467705000794	catalytic triad [active]
467705000795	oxyanion hole [active]
467705000796	copper transport repressor, CopY/TcrY family; Region: CopY_TcrY; TIGR02698
467705000797	Penicillinase repressor; Region: Pencillinase_R; pfam03965
467705000798	Cupredoxin-like domain; Region: Cupredoxin_1; pfam13473
467705000799	Cupredoxin-like domain; Region: Cupredoxin_1; cl17234
467705000800	copper-(or silver)-translocating P-type ATPase; Region: ATPase-IB1_Cu; TIGR01511
467705000801	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
467705000802	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
467705000803	motif II; other site
467705000804	Pyrimidine (PYR) binding domain of POX; Region: TPP_PYR_POX; cd07039
467705000805	pyruvate oxidase; Region: pyruv_oxi_spxB; TIGR02720
467705000806	PYR/PP interface [polypeptide binding]; other site
467705000807	dimer interface [polypeptide binding]; other site
467705000808	tetramer interface [polypeptide binding]; other site
467705000809	TPP binding site [chemical binding]; other site
467705000810	Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205
467705000811	Thiamine pyrophosphate (TPP) family, Pyruvate oxidase (POX) subfamily, TPP-binding module; composed of proteins similar to Lactobacillus plantarum POX, which plays a key role in controlling acetate production under aerobic conditions. POX decarboxylates...; Region: TPP_POX; cd02014
467705000812	TPP-binding site [chemical binding]; other site
467705000813	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
467705000814	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632
467705000815	active site
467705000816	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
467705000817	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
467705000818	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
467705000819	Walker A/P-loop; other site
467705000820	ATP binding site [chemical binding]; other site
467705000821	Q-loop/lid; other site
467705000822	ABC transporter signature motif; other site
467705000823	Walker B; other site
467705000824	D-loop; other site
467705000825	H-loop/switch region; other site
467705000826	Sugar efflux transporter for intercellular exchange; Region: MtN3_slv; pfam03083
467705000827	6-phospho-beta-glucosidase; Reviewed; Region: arb; PRK09593
467705000828	beta-galactosidase; Region: BGL; TIGR03356
467705000829	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
467705000830	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
467705000831	active site
467705000832	phosphorylation site [posttranslational modification]
467705000833	intermolecular recognition site; other site
467705000834	dimerization interface [polypeptide binding]; other site
467705000835	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
467705000836	DNA binding site [nucleotide binding]
467705000837	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
467705000838	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
467705000839	dimer interface [polypeptide binding]; other site
467705000840	phosphorylation site [posttranslational modification]
467705000841	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
467705000842	ATP binding site [chemical binding]; other site
467705000843	Mg2+ binding site [ion binding]; other site
467705000844	G-X-G motif; other site
467705000845	ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730
467705000846	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
467705000847	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
467705000848	Walker A/P-loop; other site
467705000849	ATP binding site [chemical binding]; other site
467705000850	Q-loop/lid; other site
467705000851	ABC transporter signature motif; other site
467705000852	Walker B; other site
467705000853	D-loop; other site
467705000854	H-loop/switch region; other site
467705000855	ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730
467705000856	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
467705000857	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
467705000858	Walker A/P-loop; other site
467705000859	ATP binding site [chemical binding]; other site
467705000860	Q-loop/lid; other site
467705000861	ABC transporter signature motif; other site
467705000862	Walker B; other site
467705000863	D-loop; other site
467705000864	H-loop/switch region; other site
467705000865	ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730
467705000866	ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730
467705000867	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
467705000868	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
467705000869	Walker A/P-loop; other site
467705000870	ATP binding site [chemical binding]; other site
467705000871	Q-loop/lid; other site
467705000872	ABC transporter signature motif; other site
467705000873	Walker B; other site
467705000874	D-loop; other site
467705000875	H-loop/switch region; other site
467705000876	aminodeoxychorismate synthase; Provisional; Region: PRK07508
467705000877	chorismate binding enzyme; Region: Chorismate_bind; cl10555
467705000878	PyridoxaL 5'-Phosphate Dependent Enzymes class IV (PLPDE_IV). This D-amino acid superfamily, one of five classes of PLPDE, consists of branched-chain amino acid aminotransferases (BCAT), D-amino acid transferases (DAAT), and...; Region: PLPDE_IV; cl00224
467705000879	substrate-cofactor binding pocket; other site
467705000880	Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115
467705000881	pyridoxal 5'-phosphate binding site [chemical binding]; other site
467705000882	catalytic residue [active]
467705000883	5-methyltetrahydropteroyltriglutamate--homocysteine S-methyltransferase; Provisional; Region: PRK05222
467705000884	CIMS - Cobalamine-independent methonine synthase, or MetE, N-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_N_terminal_like; cd03312
467705000885	THF binding site; other site
467705000886	CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311
467705000887	substrate binding site [chemical binding]; other site
467705000888	THF binding site; other site
467705000889	zinc-binding site [ion binding]; other site
467705000890	Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cd00537
467705000891	FAD binding site [chemical binding]; other site
467705000892	putative phosphoketolase; Provisional; Region: PRK05261
467705000893	XFP N-terminal domain; Region: XFP_N; pfam09364
467705000894	XFP C-terminal domain; Region: XFP_C; pfam09363
467705000895	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
467705000896	haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282
467705000897	active site
467705000898	motif I; other site
467705000899	motif II; other site
467705000900	haloacid dehalogenase-like hydrolase; Region: HAD; cl17202
467705000901	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
467705000902	catalytic core [active]
467705000903	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
467705000904	catalytic core [active]
467705000905	Subtilisin-like serine proteases [Posttranslational modification, protein turnover, chaperones]; Region: AprE; COG1404
467705000906	Peptidase S8 family domain in Streptococcal C5a peptidases; Region: Peptidases_S8_C5a_Peptidase; cd07475
467705000907	putative active site [active]
467705000908	catalytic triad [active]
467705000909	PA: Protease-associated (PA) domain. The PA domain is an insert domain in a diverse fraction of proteases. The significance of the PA domain to many of the proteins in which it is inserted is undetermined. It may be a protein-protein interaction domain; Region: PA; cl08238
467705000910	PA/protease or protease-like domain interface [polypeptide binding]; other site
467705000911	Peptidase S8 family domain in Streptococcal C5a peptidases; Region: Peptidases_S8_C5a_Peptidase; cd07475
467705000912	Fn3-like domain (DUF1034); Region: DUF1034; pfam06280
467705000913	C-terminal domain of CHU protein family; Region: CHU_C; cl17875
467705000914	Gram-positive signal peptide, YSIRK family; Region: YSIRK_signal; TIGR01168
467705000915	Subtilisin-like serine proteases [Posttranslational modification, protein turnover, chaperones]; Region: AprE; COG1404
467705000916	Peptidase S8 family domain in Streptococcal C5a peptidases; Region: Peptidases_S8_C5a_Peptidase; cd07475
467705000917	putative active site [active]
467705000918	catalytic triad [active]
467705000919	PA domain; Region: PA; pfam02225
467705000920	PA/protease or protease-like domain interface [polypeptide binding]; other site
467705000921	Peptidase S8 family domain in Streptococcal C5a peptidases; Region: Peptidases_S8_C5a_Peptidase; cd07475
467705000922	Fn3-like domain (DUF1034); Region: DUF1034; pfam06280
467705000923	FlgD Tudor-like domain; Region: FLgD_tudor; pfam13861
467705000924	LPXTG-motif cell wall anchor domain; Region: LPXTG_anchor; TIGR01167
467705000925	Predicted periplasmic protein (DUF2233); Region: DUF2233; pfam09992
467705000926	DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179
467705000927	Ligand binding site; other site
467705000928	Putative Catalytic site; other site
467705000929	DXD motif; other site
467705000930	GtrA-like protein; Region: GtrA; pfam04138
467705000931	Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487
467705000932	active site
467705000933	catalytic residues [active]
467705000934	metal binding site [ion binding]; metal-binding site
467705000935	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
467705000936	Major Facilitator Superfamily; Region: MFS_1; pfam07690
467705000937	putative substrate translocation pore; other site
467705000938	16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187
467705000939	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
467705000940	RNA binding surface [nucleotide binding]; other site
467705000941	Pseudouridine synthase, Escherichia coli RsuA like; Region: PseudoU_synth_RsuA; cd02553
467705000942	active site
467705000943	uracil binding [chemical binding]; other site
467705000944	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
467705000945	NAD(P) binding site [chemical binding]; other site
467705000946	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
467705000947	active site
467705000948	Domain of unknown function (DUF4118); Region: DUF4118; pfam13493
467705000949	Uncharacterized protein conserved in bacteria (DUF2194); Region: DUF2194; pfam09960
467705000950	Putative NodB-like catalytic domain of uncharacterized proteins found in bacteria; Region: CE4_COG4878; cd10924
467705000951	NodB motif; other site
467705000952	putative active site [active]
467705000953	putative catalytic site [active]
467705000954	putative Zn binding site [ion binding]; other site
467705000955	This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_3; cd03813
467705000956	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
467705000957	Predicted membrane protein [Function unknown]; Region: COG4267
467705000958	CotH protein; Region: CotH; pfam08757
467705000959	Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063
467705000960	Interdomain contacts; other site
467705000961	Cytokine receptor motif; other site
467705000962	Polyphosphate(polyP) polymerase domain of yeast vacuolar transport chaperone (VTC) proteins VTC-2, -3 and- 4, and similar proteins; Region: PolyPPase_VTC_like; cd07750
467705000963	putative metal binding residues [ion binding]; other site
467705000964	signature motif; other site
467705000965	dimer interface [polypeptide binding]; other site
467705000966	active site
467705000967	polyP binding site; other site
467705000968	substrate binding site [chemical binding]; other site
467705000969	acceptor-phosphate pocket; other site
467705000970	Beta-galactosidase; Region: Glyco_hydro_42; pfam02449
467705000971	Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353
467705000972	16S/18S rRNA binding site [nucleotide binding]; other site
467705000973	S13e-L30e interaction site [polypeptide binding]; other site
467705000974	25S rRNA binding site [nucleotide binding]; other site
467705000975	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
467705000976	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
467705000977	TAP-like protein; Region: Abhydrolase_4; pfam08386
467705000978	Protein of unknown function (DUF2992); Region: DUF2992; pfam11208
467705000979	TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947
467705000980	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
467705000981	catalytic residues [active]
467705000982	Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cd00333
467705000983	amphipathic channel; other site
467705000984	Asn-Pro-Ala signature motifs; other site
467705000985	Protein of unknown function (DUF2785); Region: DUF2785; pfam10978
467705000986	SnoaL-like domain; Region: SnoaL_2; pfam12680
467705000987	oligoendopeptidase F; Region: pepF; TIGR00181
467705000988	Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins); Region: GluZincin; cl14813
467705000989	Zn binding site [ion binding]; other site
467705000990	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
467705000991	Major Facilitator Superfamily; Region: MFS_1; pfam07690
467705000992	putative substrate translocation pore; other site
467705000993	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
467705000994	putative substrate translocation pore; other site
467705000995	polynucleotide phosphorylase/polyadenylase; Provisional; Region: PRK11824
467705000996	Polyribonucleotide nucleotidyltransferase, repeat 1; Region: RNase_PH_PNPase_1; cd11363
467705000997	RNase E interface [polypeptide binding]; other site
467705000998	trimer interface [polypeptide binding]; other site
467705000999	Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726
467705001000	Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364
467705001001	RNase E interface [polypeptide binding]; other site
467705001002	trimer interface [polypeptide binding]; other site
467705001003	active site
467705001004	Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393
467705001005	S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase  is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472
467705001006	RNA binding site [nucleotide binding]; other site
467705001007	domain interface; other site
467705001008	Serine acetyltransferase [Amino acid transport and metabolism]; Region: CysE; COG1045
467705001009	Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354
467705001010	trimer interface [polypeptide binding]; other site
467705001011	active site
467705001012	substrate binding site [chemical binding]; other site
467705001013	Bacteriocin-protection, YdeI or OmpD-Associated; Region: OmdA; pfam13376
467705001014	Phosphorylase superfamily; Region: PNP_UDP_1; pfam01048
467705001015	Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cl17426
467705001016	NADP+ binding site [chemical binding]; other site
467705001017	RibD C-terminal domain; Region: RibD_C; cl17279
467705001018	cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260
467705001019	catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672
467705001020	active site
467705001021	HIGH motif; other site
467705001022	catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672
467705001023	KMSKS motif; other site
467705001024	Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020
467705001025	tRNA binding surface [nucleotide binding]; other site
467705001026	anticodon binding site; other site
467705001027	RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593
467705001028	active site
467705001029	metal binding site [ion binding]; metal-binding site
467705001030	dimerization interface [polypeptide binding]; other site
467705001031	Regulator of polyketide synthase expression [Signal transduction mechanisms / Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2508
467705001032	PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556
467705001033	glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650
467705001034	The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301
467705001035	Walker A/P-loop; other site
467705001036	ATP binding site [chemical binding]; other site
467705001037	Q-loop/lid; other site
467705001038	ABC transporter signature motif; other site
467705001039	Walker B; other site
467705001040	D-loop; other site
467705001041	H-loop/switch region; other site
467705001042	TOBE domain; Region: TOBE_2; pfam08402
467705001043	Amino acid permease; Region: AA_permease_2; pfam13520
467705001044	Predicted membrane protein [Function unknown]; Region: COG4129
467705001045	Bacterial protein of unknown function (DUF939); Region: DUF939; pfam06081
467705001046	DUF939 C-terminal domain; Region: DUF939_C; pfam11728
467705001047	rRNA methylase, putative, group 3; Region: rRNA_methyl_3; TIGR00186
467705001048	RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032
467705001049	SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588
467705001050	EDD domain protein, DegV family; Region: DegV; TIGR00762
467705001051	Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645
467705001052	Ribosomal protein L13.  Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392
467705001053	23S rRNA interface [nucleotide binding]; other site
467705001054	L3 interface [polypeptide binding]; other site
467705001055	30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132
467705001056	Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582
467705001057	phiLC3 phage and phage-related integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes various bacterial (mainly gram positive) and phage integrases, including those similar to Lactococcus...; Region: INT_phiLC3_C; cd01189
467705001058	Int/Topo IB signature motif; other site
467705001059	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
467705001060	non-specific DNA binding site [nucleotide binding]; other site
467705001061	salt bridge; other site
467705001062	sequence-specific DNA binding site [nucleotide binding]; other site
467705001063	Phage DNA packaging protein Nu1; Region: Phage_Nu1; cl01720
467705001064	N-terminal phage replisome organiser (Phage_rep_org_N); Region: Phage_rep_org_N; pfam09681
467705001065	Predicted permease, cadmium resistance protein [Inorganic ion transport and metabolism]; Region: CadD; COG4300
467705001066	Cadmium resistance transporter; Region: Cad; pfam03596
467705001067	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
467705001068	putative DNA binding site [nucleotide binding]; other site
467705001069	putative Zn2+ binding site [ion binding]; other site
467705001070	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371
467705001071	metal-binding site [ion binding]
467705001072	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371
467705001073	metal-binding site [ion binding]
467705001074	mercuric reductase; Region: MerA; TIGR02053
467705001075	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
467705001076	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
467705001077	Transcriptional regulator [Transcription]; Region: LysR; COG0583
467705001078	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
467705001079	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
467705001080	dimerization interface [polypeptide binding]; other site
467705001081	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
467705001082	non-specific DNA binding site [nucleotide binding]; other site
467705001083	salt bridge; other site
467705001084	sequence-specific DNA binding site [nucleotide binding]; other site
467705001085	malate dehydrogenase; Provisional; Region: PRK13529
467705001086	Malic enzyme, N-terminal domain; Region: malic; pfam00390
467705001087	NAD(P) binding domain of malic enzyme (ME), subgroup 1; Region: NAD_bind_1_malic_enz; cd05312
467705001088	NAD(P) binding site [chemical binding]; other site
467705001089	Membrane transport protein; Region: Mem_trans; cl09117
467705001090	Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279
467705001091	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
467705001092	active site
467705001093	phosphorylation site [posttranslational modification]
467705001094	intermolecular recognition site; other site
467705001095	dimerization interface [polypeptide binding]; other site
467705001096	LytTr DNA-binding domain; Region: LytTR; pfam04397
467705001097	ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121
467705001098	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
467705001099	Walker A/P-loop; other site
467705001100	ATP binding site [chemical binding]; other site
467705001101	Q-loop/lid; other site
467705001102	ABC transporter signature motif; other site
467705001103	Walker B; other site
467705001104	D-loop; other site
467705001105	H-loop/switch region; other site
467705001106	Predicted membrane protein [Function unknown]; Region: COG2323
467705001107	Protein of unknown function (DUF3290); Region: DUF3290; pfam11694
467705001108	Sodium:dicarboxylate symporter family; Region: SDF; pfam00375
467705001109	Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301
467705001110	alpha-L-glutamate ligases, RimK family; Region: rimK_fam; TIGR00768
467705001111	ATP-grasp domain; Region: ATP-grasp_4; cl17255
467705001112	Domain of Unknown Function (DUF1080); Region: DUF1080; pfam06439
467705001113	Cadherin-like beta sandwich domain; Region: Cadherin-like; pfam12733
467705001114	Glycosyl hydrolases family 32; Region: Glyco_32; smart00640
467705001115	Glycosyl hydrolase family 32, beta-fructosidases; Region: GH32_B_Fructosidase; cd08996
467705001116	substrate binding [chemical binding]; other site
467705001117	active site
467705001118	Glycosyl hydrolases family 32 C terminal; Region: Glyco_hydro_32C; pfam08244
467705001119	Bacterial Ig-like domain 2; Region: BID_2; smart00635
467705001120	Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of...; Region: LamG; cl17353
467705001121	G5 domain; Region: G5; pfam07501
467705001122	Helix-Turn-Helix DNA binding domain of the BmrR transcription regulator; Region: HTH_BmrR; cd01107
467705001123	MerR HTH family regulatory protein; Region: MerR_1; pfam13411
467705001124	DNA binding residues [nucleotide binding]
467705001125	drug binding residues [chemical binding]; other site
467705001126	dimer interface [polypeptide binding]; other site
467705001127	Uncharacterized conserved protein related to dihydrodipicolinate reductase [Function unknown]; Region: COG3804
467705001128	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
467705001129	M14 family of metallocarboxypeptidases and related proteins; Region: Peptidase_M14_like; cl11393
467705001130	active site
467705001131	Zn binding site [ion binding]; other site
467705001132	Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919
467705001133	LPXTG-motif cell wall anchor domain; Region: LPXTG_anchor; TIGR01167
467705001134	ACT domain proteins similar to the yet uncharacterized Streptococcus pneumoniae ACT domain protein; Region: ACT_1ZPV; cd04872
467705001135	Uncharacterized proteins with similarity to Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL_like_DUF711; cd08025
467705001136	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
467705001137	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
467705001138	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
467705001139	catalytic core [active]
467705001140	D-alanyl-D-alanine carboxypeptidase; Region: VanY; pfam02557
467705001141	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
467705001142	non-specific DNA binding site [nucleotide binding]; other site
467705001143	salt bridge; other site
467705001144	sequence-specific DNA binding site [nucleotide binding]; other site
467705001145	Predicted transcriptional regulators [Transcription]; Region: COG1695
467705001146	Transcriptional regulator PadR-like family; Region: PadR; pfam03551
467705001147	Protein of unknown function (DUF2812); Region: DUF2812; pfam11193
467705001148	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
467705001149	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
467705001150	Walker A/P-loop; other site
467705001151	ATP binding site [chemical binding]; other site
467705001152	Q-loop/lid; other site
467705001153	ABC transporter signature motif; other site
467705001154	Walker B; other site
467705001155	D-loop; other site
467705001156	H-loop/switch region; other site
467705001157	heat-inducible transcription repressor; Provisional; Region: hrcA; PRK00082
467705001158	Winged helix-turn-helix transcription repressor, HrcA DNA-binding; Region: HrcA_DNA-bdg; pfam03444
467705001159	GrpE; Region: GrpE; pfam01025
467705001160	GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446
467705001161	dimer interface [polypeptide binding]; other site
467705001162	hsp70 (ATPase domain) interactions [polypeptide binding]; other site
467705001163	molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290
467705001164	Nucleotide-binding domain of human HSPA9 and similar proteins; Region: HSPA9-Ssq1-like_NBD; cd10234
467705001165	nucleotide binding site [chemical binding]; other site
467705001166	NEF interaction site [polypeptide binding]; other site
467705001167	SBD interface [polypeptide binding]; other site
467705001168	Putative intracellular protease/amidase [General function prediction only]; Region: ThiJ; COG0693
467705001169	Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020
467705001170	conserved cys residue [active]
467705001171	chaperone protein DnaJ; Provisional; Region: PRK14276
467705001172	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257
467705001173	HSP70 interaction site [polypeptide binding]; other site
467705001174	C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cl03262
467705001175	substrate binding site [polypeptide binding]; other site
467705001176	Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719
467705001177	Zn binding sites [ion binding]; other site
467705001178	C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747
467705001179	dimer interface [polypeptide binding]; other site
467705001180	Gram-positive signal peptide, YSIRK family; Region: YSIRK_signal; TIGR01168
467705001181	N-acetyl-beta-hexosaminidase [Carbohydrate transport and metabolism]; Region: Chb; COG3525
467705001182	Glycosyl hydrolase family 20 (GH20) catalytic domain of dispersin B (DspB), lacto-N-biosidase (LnbB) and related proteins. Dispersin B is a soluble beta-N-acetylglucosamidase found in bacteria that hydrolyzes the beta-1,6-linkages of PGA (poly-beta-(1,6)...; Region: GH20_DspB_LnbB-like; cd06564
467705001183	active site
467705001184	Glycosyl hydrolase family 20 (GH20) catalytic domain of dispersin B (DspB), lacto-N-biosidase (LnbB) and related proteins. Dispersin B is a soluble beta-N-acetylglucosamidase found in bacteria that hydrolyzes the beta-1,6-linkages of PGA (poly-beta-(1,6)...; Region: GH20_DspB_LnbB-like; cd06564
467705001185	active site
467705001186	G5 domain; Region: G5; pfam07501
467705001187	Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447
467705001188	nudix motif; other site
467705001189	tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021
467705001190	Eukaryotic and bacterial pseudouridine synthases similar to E.  coli TruA; Region: PseudoU_synth_EcTruA; cd02570
467705001191	dimerization interface 3.5A [polypeptide binding]; other site
467705001192	active site
467705001193	Gram-positive signal peptide, YSIRK family; Region: YSIRK_signal; TIGR01168
467705001194	G5 domain; Region: G5; pfam07501
467705001195	M26 IgA1-specific Metallo-endopeptidase N-terminal region; Region: Peptidase_M26_N; pfam05342
467705001196	M26 IgA1-specific Metallo-endopeptidase C-terminal region; Region: Peptidase_M26_C; pfam07580
467705001197	4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169
467705001198	substrate binding site [chemical binding]; other site
467705001199	dimer interface [polypeptide binding]; other site
467705001200	ATP binding site [chemical binding]; other site
467705001201	ECF-type riboflavin transporter, S component; Region: ECF-ribofla_trS; pfam07155
467705001202	hypothetical protein; Provisional; Region: PRK13690
467705001203	trigger factor; Provisional; Region: tig; PRK01490
467705001204	FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254
467705001205	Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698
467705001206	DNA-directed RNA polymerase delta subunit; Region: RNA_pol_delta; pfam05066
467705001207	Solo B3/4 domain (OB-fold DNA/RNA-binding) of Phe-aaRS-beta [General function prediction only]; Region: COG3382
467705001208	B3/4 domain; Region: B3_4; pfam03483
467705001209	preprotein translocase subunit SecA; Reviewed; Region: PRK12904
467705001210	SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958
467705001211	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
467705001212	nucleotide binding region [chemical binding]; other site
467705001213	ATP-binding site [chemical binding]; other site
467705001214	SEC-C motif; Region: SEC-C; pfam02810
467705001215	phospho-2-dehydro-3-deoxyheptonate aldolase; Validated; Region: PRK09261
467705001216	DAHP synthetase I family; Region: DAHP_synth_1; pfam00793
467705001217	4'-phosphopantetheinyl transferase; Provisional; Region: acpS; PRK00070
467705001218	alanine racemase; Reviewed; Region: alr; PRK00053
467705001219	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430
467705001220	active site
467705001221	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
467705001222	dimer interface [polypeptide binding]; other site
467705001223	substrate binding site [chemical binding]; other site
467705001224	catalytic residues [active]
467705001225	ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917
467705001226	Y-family of DNA polymerases; Region: PolY; cl12025
467705001227	RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488
467705001228	ssDNA binding site; other site
467705001229	generic binding surface II; other site
467705001230	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
467705001231	ATP binding site [chemical binding]; other site
467705001232	putative Mg++ binding site [ion binding]; other site
467705001233	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
467705001234	nucleotide binding region [chemical binding]; other site
467705001235	ATP-binding site [chemical binding]; other site
467705001236	Transcriptional antiterminator [Transcription]; Region: BglG; COG3711
467705001237	PRD domain; Region: PRD; pfam00874
467705001238	PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568
467705001239	active site
467705001240	P-loop; other site
467705001241	phosphorylation site [posttranslational modification]
467705001242	PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211
467705001243	active site
467705001244	phosphorylation site [posttranslational modification]
467705001245	PTS_IIB_ascorbate: subunit IIB of enzyme II (EII) of the L-ascorbate-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is an L-ascorbate-specific permease with two cytoplasmic subunits (IIA and IIB) and a...; Region: PTS_IIB_ascorbate; cd05563
467705001246	active site
467705001247	P-loop; other site
467705001248	phosphorylation site [posttranslational modification]
467705001249	PTS system ascorbate-specific transporter subunit IIC; Reviewed; Region: ulaA; PRK09410
467705001250	TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186
467705001251	phosphate binding site [ion binding]; other site
467705001252	Type II (periplasmic) bacterial L-asparaginase; Region: L-asparaginase_II; cd08964
467705001253	active site
467705001254	homotetramer interface [polypeptide binding]; other site
467705001255	homodimer interface [polypeptide binding]; other site
467705001256	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
467705001257	haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282
467705001258	active site
467705001259	motif I; other site
467705001260	motif II; other site
467705001261	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
467705001262	Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in Exiguobacterium sibiricum YP_001813558.1 protein and its bacterial homologs; Region: NTP-PPase_YP_001813558; cd11545
467705001263	putative nucleotide binding site [chemical binding]; other site
467705001264	putative metal binding site [ion binding]; other site
467705001265	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
467705001266	Ligand Binding Site [chemical binding]; other site
467705001267	aminotransferase AlaT; Validated; Region: PRK09265
467705001268	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
467705001269	pyridoxal 5'-phosphate binding site [chemical binding]; other site
467705001270	homodimer interface [polypeptide binding]; other site
467705001271	catalytic residue [active]
467705001272	SEC10/PgrA surface exclusion domain; Region: Surf_Exclu_PgrA; TIGR04320
467705001273	LPXTG-motif cell wall anchor domain; Region: LPXTG_anchor; TIGR01167
467705001274	Pleiotropic transcriptional repressor [Transcription]; Region: CodY; COG4465
467705001275	CodY GAF-like domain; Region: CodY; pfam06018
467705001276	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
467705001277	dimerization interface [polypeptide binding]; other site
467705001278	putative Zn2+ binding site [ion binding]; other site
467705001279	putative DNA binding site [nucleotide binding]; other site
467705001280	Isochorismatase family; Region: Isochorismatase; pfam00857
467705001281	Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431
467705001282	catalytic triad [active]
467705001283	conserved cis-peptide bond; other site
467705001284	aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476
467705001285	EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317
467705001286	dimer interface [polypeptide binding]; other site
467705001287	anticodon binding site; other site
467705001288	Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777
467705001289	homodimer interface [polypeptide binding]; other site
467705001290	motif 1; other site
467705001291	active site
467705001292	motif 2; other site
467705001293	GAD domain; Region: GAD; pfam02938
467705001294	Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA.   PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268
467705001295	active site
467705001296	motif 3; other site
467705001297	aspartyl/glutamyl-tRNA amidotransferase subunit C; Reviewed; Region: gatC; PRK00034
467705001298	Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154
467705001299	aspartyl/glutamyl-tRNA amidotransferase subunit A; Reviewed; Region: gatA; PRK00012
467705001300	aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477
467705001301	GatB/GatE catalytic domain; Region: GatB_N; pfam02934
467705001302	GatB domain; Region: GatB_Yqey; pfam02637
467705001303	GatB domain; Region: GatB_Yqey; smart00845
467705001304	Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063
467705001305	(2R,3R)-2,3-butanediol dehydrogenase; Region: butanediol_DH_like; cd08233
467705001306	putative NAD(P) binding site [chemical binding]; other site
467705001307	catalytic Zn binding site [ion binding]; other site
467705001308	Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697
467705001309	EamA-like transporter family; Region: EamA; pfam00892
467705001310	Uncharacterized conserved protein [Function unknown]; Region: COG0398
467705001311	SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335
467705001312	Predicted hydrolase of the HAD superfamily [General function prediction only]; Region: COG2179
467705001313	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
467705001314	active site
467705001315	motif I; other site
467705001316	motif II; other site
467705001317	GTPase YqeH; Provisional; Region: PRK13796
467705001318	Circularly permuted YqeH GTPase; Region: YqeH; cd01855
467705001319	GTP/Mg2+ binding site [chemical binding]; other site
467705001320	G4 box; other site
467705001321	G5 box; other site
467705001322	G1 box; other site
467705001323	Switch I region; other site
467705001324	G2 box; other site
467705001325	G3 box; other site
467705001326	Switch II region; other site
467705001327	Predicted RNA-binding protein containing KH domain, possibly ribosomal protein [Translation, ribosomal structure and biogenesis]; Region: COG1534
467705001328	nicotinic acid mononucleotide adenylyltransferase; Provisional; Region: nadD; PRK00071
467705001329	Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165
467705001330	active site
467705001331	(T/H)XGH motif; other site
467705001332	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
467705001333	Zn2+ binding site [ion binding]; other site
467705001334	Mg2+ binding site [ion binding]; other site
467705001335	Isochorismatase family; Region: Isochorismatase; pfam00857
467705001336	Nicotinamidase_ related amidohydrolases.  Cysteine hydrolases of unknown function that share the catalytic triad with other amidohydrolases, like nicotinamidase, which converts nicotinamide to nicotinic acid and ammonia; Region: nicotinamidase_related; cd01014
467705001337	catalytic triad [active]
467705001338	conserved cis-peptide bond; other site
467705001339	Uncharacterized homolog of plant Iojap protein [Function unknown]; Region: COG0799
467705001340	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
467705001341	S-adenosylmethionine binding site [chemical binding]; other site
467705001342	hypothetical protein; Provisional; Region: PRK13670
467705001343	HIGH Nucleotidyl Transferase; Region: HIGH_NTase1; pfam05636
467705001344	hypothetical protein; Provisional; Region: PRK12378
467705001345	Domain of unknown function (DUF4352); Region: DUF4352; pfam11611
467705001346	Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473
467705001347	M20 Peptidase Aminoacyclase-1 YxeP-like proteins, including YxeP, YtnL, YjiB and HipO2; Region: M20_Acy1_YxeP_like; cd05669
467705001348	metal binding site [ion binding]; metal-binding site
467705001349	dimer interface [polypeptide binding]; other site
467705001350	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
467705001351	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
467705001352	substrate binding pocket [chemical binding]; other site
467705001353	membrane-bound complex binding site; other site
467705001354	hinge residues; other site
467705001355	ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464
467705001356	NLPA lipoprotein; Region: Lipoprotein_9; pfam03180
467705001357	hypothetical protein; Provisional; Region: PRK06446
467705001358	Uncharacterized M20 Dipeptidases; Region: M20_dipept_like_4; cd05681
467705001359	metal binding site [ion binding]; metal-binding site
467705001360	dimer interface [polypeptide binding]; other site
467705001361	ABC-type metal ion transport system, ATPase component [Inorganic ion transport and metabolism]; Region: AbcC; COG1135
467705001362	ATP-binding cassette domain of methionine transporter; Region: ABC_MetN_methionine_transporter; cd03258
467705001363	Walker A/P-loop; other site
467705001364	ATP binding site [chemical binding]; other site
467705001365	Q-loop/lid; other site
467705001366	ABC transporter signature motif; other site
467705001367	Walker B; other site
467705001368	D-loop; other site
467705001369	H-loop/switch region; other site
467705001370	This domain is found at the C-terminus of ABC transporter proteins involved in D-methionine transport as well as a number of ferredoxin-like proteins; Region: NIL; smart00930
467705001371	ABC-type metal ion transport system, permease component [Inorganic ion transport and metabolism]; Region: AbcD; COG2011
467705001372	ABC-type transport system involved in cytochrome bd biosynthesis, ATPase and permease components [Energy production and conversion / Posttranslational modification, protein turnover, chaperones]; Region: CydD; COG4988
467705001373	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
467705001374	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
467705001375	Walker A/P-loop; other site
467705001376	ATP binding site [chemical binding]; other site
467705001377	Q-loop/lid; other site
467705001378	ABC transporter signature motif; other site
467705001379	Walker B; other site
467705001380	D-loop; other site
467705001381	H-loop/switch region; other site
467705001382	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
467705001383	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
467705001384	ATP-binding cassette domain of multidrug resistance protein-like transporters; Region: ABCC_MRP_Like; cd03228
467705001385	Walker A/P-loop; other site
467705001386	ATP binding site [chemical binding]; other site
467705001387	Q-loop/lid; other site
467705001388	ABC transporter signature motif; other site
467705001389	Walker B; other site
467705001390	D-loop; other site
467705001391	H-loop/switch region; other site
467705001392	Hypothetical bacterial integral membrane protein (Trep_Strep); Region: Trep_Strep; pfam09605
467705001393	ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619
467705001394	ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122
467705001395	First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225
467705001396	Walker A/P-loop; other site
467705001397	ATP binding site [chemical binding]; other site
467705001398	Q-loop/lid; other site
467705001399	ABC transporter signature motif; other site
467705001400	Walker B; other site
467705001401	D-loop; other site
467705001402	H-loop/switch region; other site
467705001403	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
467705001404	cobalt transport protein ATP-binding subunit; Region: cbiO; TIGR01166
467705001405	Walker A/P-loop; other site
467705001406	ATP binding site [chemical binding]; other site
467705001407	Q-loop/lid; other site
467705001408	ABC transporter signature motif; other site
467705001409	Walker B; other site
467705001410	D-loop; other site
467705001411	H-loop/switch region; other site
467705001412	Uncharacterized conserved protein [Function unknown]; Region: COG1912
467705001413	hypothetical protein; Provisional; Region: PRK13661
467705001414	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
467705001415	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
467705001416	non-specific DNA binding site [nucleotide binding]; other site
467705001417	salt bridge; other site
467705001418	sequence-specific DNA binding site [nucleotide binding]; other site
467705001419	CAAX protease self-immunity; Region: Abi; pfam02517
467705001420	putative rhodanese-related sulfurtransferase; Provisional; Region: PRK00142
467705001421	Member of the Rhodanese Homology Domain superfamily. This CD includes Escherichia coli YceA, Bacillus subtilis YbfQ, and similar uncharacterized proteins; Region: RHOD_YceA; cd01518
467705001422	active site residue [active]
467705001423	Protein of unknown function (DUF3650); Region: DUF3650; pfam12368
467705001424	FOG: Glucan-binding domain (YG repeat) [General function prediction only]; Region: COG5263
467705001425	FOG: Glucan-binding domain (YG repeat) [General function prediction only]; Region: COG5263
467705001426	glucan-binding repeat; Region: glucan_65_rpt; TIGR04035
467705001427	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
467705001428	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
467705001429	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
467705001430	Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588
467705001431	dimer interface [polypeptide binding]; other site
467705001432	DJ-1 family protein; Region: not_thiJ; TIGR01383
467705001433	Type 1 glutamine amidotransferase (GATase1)-like domain found in a subgroup of proteins similar to PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_2; cd03139
467705001434	conserved cys residue [active]
467705001435	Domain of unknown function (DUF4299); Region: DUF4299; pfam14132
467705001436	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
467705001437	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
467705001438	dimer interface [polypeptide binding]; other site
467705001439	phosphorylation site [posttranslational modification]
467705001440	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
467705001441	ATP binding site [chemical binding]; other site
467705001442	Mg2+ binding site [ion binding]; other site
467705001443	G-X-G motif; other site
467705001444	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
467705001445	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
467705001446	active site
467705001447	phosphorylation site [posttranslational modification]
467705001448	intermolecular recognition site; other site
467705001449	dimerization interface [polypeptide binding]; other site
467705001450	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
467705001451	DNA binding site [nucleotide binding]
467705001452	Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399
467705001453	synthetase active site [active]
467705001454	NTP binding site [chemical binding]; other site
467705001455	metal binding site [ion binding]; metal-binding site
467705001456	Phosphorylase superfamily; Region: PNP_UDP_1; pfam01048
467705001457	ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122
467705001458	First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225
467705001459	Walker A/P-loop; other site
467705001460	ATP binding site [chemical binding]; other site
467705001461	Q-loop/lid; other site
467705001462	ABC transporter signature motif; other site
467705001463	Walker B; other site
467705001464	D-loop; other site
467705001465	H-loop/switch region; other site
467705001466	ATP-binding cassette cobalt transporter; Region: DUF3744; pfam12558
467705001467	ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122
467705001468	First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225
467705001469	Walker A/P-loop; other site
467705001470	ATP binding site [chemical binding]; other site
467705001471	Q-loop/lid; other site
467705001472	ABC transporter signature motif; other site
467705001473	Walker B; other site
467705001474	D-loop; other site
467705001475	H-loop/switch region; other site
467705001476	ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619
467705001477	CAAX protease self-immunity; Region: Abi; pfam02517
467705001478	Predicted S-adenosylmethionine-dependent methyltransferase involved in bacterial cell division [Cell envelope biogenesis, outer membrane]; Region: GidB; COG0357
467705001479	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
467705001480	S-adenosylmethionine binding site [chemical binding]; other site
467705001481	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
467705001482	putative substrate translocation pore; other site
467705001483	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
467705001484	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
467705001485	Uncharacterized conserved protein [Function unknown]; Region: LemA; COG1704
467705001486	heat shock protein HtpX; Provisional; Region: PRK04897
467705001487	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
467705001488	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
467705001489	non-specific DNA binding site [nucleotide binding]; other site
467705001490	salt bridge; other site
467705001491	sequence-specific DNA binding site [nucleotide binding]; other site
467705001492	transcriptional activator, Rgg/GadR/MutR family, C-terminal domain; Region: RGG_Cterm; TIGR01716
467705001493	glucan-binding repeat; Region: glucan_65_rpt; TIGR04035
467705001494	Glycosyl hydrolase family 70; Region: Glyco_hydro_70; pfam02324
467705001495	Alpha amylase catalytic domain family; Region: AmyAc_family; cl07893
467705001496	Alpha amylase catalytic domain family; Region: AmyAc_family; cl07893
467705001497	glucan-binding repeat; Region: glucan_65_rpt; TIGR04035
467705001498	glucan-binding repeat; Region: glucan_65_rpt; TIGR04035
467705001499	glucan-binding repeat; Region: glucan_65_rpt; TIGR04035
467705001500	glucan-binding repeat; Region: glucan_65_rpt; TIGR04035
467705001501	glucan-binding repeat; Region: glucan_65_rpt; TIGR04035
467705001502	glucan-binding repeat; Region: glucan_65_rpt; TIGR04035
467705001503	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
467705001504	non-specific DNA binding site [nucleotide binding]; other site
467705001505	salt bridge; other site
467705001506	sequence-specific DNA binding site [nucleotide binding]; other site
467705001507	transcriptional activator, Rgg/GadR/MutR family, C-terminal domain; Region: RGG_Cterm; TIGR01716
467705001508	Predicted metal-binding, possibly nucleic acid-binding protein [General function prediction only]; Region: COG1399
467705001509	Band_7_flotillin: a subgroup of the band 7 domain of flotillin (reggie) like proteins. This subgroup contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin.  These two proteins are lipid raft-associated.  Individual proteins of...; Region: Band_7_flotillin; cd03399
467705001510	6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599
467705001511	6-phosphogluconate dehydrogenase; Validated; Region: PRK09287
467705001512	6-phosphogluconate dehydrogenase, C-terminal domain; Region: 6PGD; pfam00393
467705001513	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
467705001514	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
467705001515	active site
467705001516	phosphorylation site [posttranslational modification]
467705001517	intermolecular recognition site; other site
467705001518	dimerization interface [polypeptide binding]; other site
467705001519	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
467705001520	DNA binding site [nucleotide binding]
467705001521	Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263
467705001522	PTS system, IIBC component; Region: PTS-II-BC-unk1; TIGR02003
467705001523	PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212
467705001524	active site turn [active]
467705001525	phosphorylation site [posttranslational modification]
467705001526	Phosphotransferase system IIA components [Carbohydrate transport and metabolism]; Region: NagE; COG2190
467705001527	HPr interaction site; other site
467705001528	glycerol kinase (GK) interaction site [polypeptide binding]; other site
467705001529	active site
467705001530	phosphorylation site [posttranslational modification]
467705001531	Streptococcus agalactiae RgfB, part of a putative two component signal transduction system, and related proteins; Region: RgfB-like; cd09079
467705001532	putative catalytic site [active]
467705001533	putative metal binding site [ion binding]; other site
467705001534	putative phosphate binding site [ion binding]; other site
467705001535	transcriptional regulator NrdR; Validated; Region: nrdR; PRK00464
467705001536	ATP cone domain; Region: ATP-cone; pfam03477
467705001537	Replication initiation/membrane attachment protein [DNA replication, recombination, and repair]; Region: DnaB; COG3611
467705001538	primosomal protein DnaI; Reviewed; Region: PRK08939
467705001539	Primosomal protein DnaI N-terminus; Region: DnaI_N; pfam07319
467705001540	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
467705001541	Walker A motif; other site
467705001542	ATP binding site [chemical binding]; other site
467705001543	Walker B motif; other site
467705001544	This family contains NADPH-dependent flavin reductase and oxygen-insensitive nitroreductase. These enzymes are homodimeric flavoproteins that contain one FMN per monomer as a cofactor. Flavin reductase catalyzes the reduction of flavin by using NADPH as...; Region: NfsA_FRP; cd02146
467705001545	dimer interface [polypeptide binding]; other site
467705001546	FMN binding site [chemical binding]; other site
467705001547	NADPH bind site [chemical binding]; other site
467705001548	GTP-binding protein Der; Reviewed; Region: PRK00093
467705001549	EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894
467705001550	G1 box; other site
467705001551	GTP/Mg2+ binding site [chemical binding]; other site
467705001552	Switch I region; other site
467705001553	G2 box; other site
467705001554	Switch II region; other site
467705001555	G3 box; other site
467705001556	G4 box; other site
467705001557	G5 box; other site
467705001558	EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895
467705001559	G1 box; other site
467705001560	GTP/Mg2+ binding site [chemical binding]; other site
467705001561	Switch I region; other site
467705001562	G2 box; other site
467705001563	G3 box; other site
467705001564	Switch II region; other site
467705001565	G4 box; other site
467705001566	G5 box; other site
467705001567	Bacterial SNF2 helicase associated; Region: SNF2_assoc; pfam08455
467705001568	Superfamily II DNA/RNA helicases, SNF2 family [Transcription / DNA replication, recombination, and repair]; Region: HepA; COG0553
467705001569	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
467705001570	ATP binding site [chemical binding]; other site
467705001571	putative Mg++ binding site [ion binding]; other site
467705001572	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
467705001573	nucleotide binding region [chemical binding]; other site
467705001574	ATP-binding site [chemical binding]; other site
467705001575	UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421
467705001576	Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225
467705001577	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
467705001578	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
467705001579	ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575
467705001580	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
467705001581	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
467705001582	Coenzyme A binding pocket [chemical binding]; other site
467705001583	ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575
467705001584	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
467705001585	Coenzyme A binding pocket [chemical binding]; other site
467705001586	Aminodeoxychorismate lyase [Coenzyme transport and metabolism]; Region: COG1559
467705001587	proteins similar to Escherichia coli yceG; Region: yceG_like; cd08010
467705001588	dimerization interface [polypeptide binding]; other site
467705001589	transcription elongation factor GreA; Reviewed; Region: greA; PRK00226
467705001590	Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449
467705001591	Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272
467705001592	OxaA-like protein precursor; Provisional; Region: PRK02463
467705001593	membrane protein insertase, YidC/Oxa1 family, C-terminal domain; Region: yidC_oxa1_cterm; TIGR03592
467705001594	acylphosphatase; Provisional; Region: PRK14434
467705001595	rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566
467705001596	RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; smart00967
467705001597	SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588
467705001598	Predicted HD superfamily hydrolase [General function prediction only]; Region: COG1418
467705001599	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
467705001600	Zn2+ binding site [ion binding]; other site
467705001601	Mg2+ binding site [ion binding]; other site
467705001602	Integral membrane protein, interacts with FtsH [General function prediction only]; Region: COG0670
467705001603	Bacterial BAX inhibitor (BI)-1/YccA-like proteins; Region: BI-1-like_bacterial; cd10432
467705001604	acetolactate synthase catalytic subunit; Reviewed; Region: PRK07282
467705001605	Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035
467705001606	PYR/PP interface [polypeptide binding]; other site
467705001607	dimer interface [polypeptide binding]; other site
467705001608	TPP binding site [chemical binding]; other site
467705001609	Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205
467705001610	Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015
467705001611	TPP-binding site [chemical binding]; other site
467705001612	dimer interface [polypeptide binding]; other site
467705001613	acetolactate synthase 3 regulatory subunit; Reviewed; Region: ilvH; PRK11895
467705001614	N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878
467705001615	putative valine binding site [chemical binding]; other site
467705001616	dimer interface [polypeptide binding]; other site
467705001617	Small subunit of acetolactate synthase; Region: ALS_ss_C; pfam10369
467705001618	ketol-acid reductoisomerase; Provisional; Region: PRK05479
467705001619	Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvN; pfam07991
467705001620	Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450
467705001621	threonine dehydratase; Validated; Region: PRK08639
467705001622	Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562
467705001623	tetramer interface [polypeptide binding]; other site
467705001624	pyridoxal 5'-phosphate binding site [chemical binding]; other site
467705001625	catalytic residue [active]
467705001626	ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141
467705001627	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
467705001628	haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282
467705001629	active site
467705001630	motif I; other site
467705001631	motif II; other site
467705001632	Protein of unknown function (DUF1361); Region: DUF1361; pfam07099
467705001633	Xanthine/uracil/vitamin C permease [Nucleotide transport and    metabolism]; Region: COG2252
467705001634	Predicted ATPase or kinase [General function prediction only]; Region: COG0802
467705001635	Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670
467705001636	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
467705001637	Coenzyme A binding pocket [chemical binding]; other site
467705001638	Transcriptional regulator [Transcription]; Region: LytR; COG1316
467705001639	HINT (histidine triad nucleotide-binding protein) subgroup: Members of this CD belong to the superfamily of histidine triad hydrolases that act on alpha-phosphate of ribonucleotides. This subgroup includes members from all three forms of cellular life; Region: HINT_subgroup; cd01277
467705001640	HIT family signature motif; other site
467705001641	catalytic residue [active]
467705001642	ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555
467705001643	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
467705001644	Walker A/P-loop; other site
467705001645	ATP binding site [chemical binding]; other site
467705001646	Q-loop/lid; other site
467705001647	ABC transporter signature motif; other site
467705001648	Walker B; other site
467705001649	D-loop; other site
467705001650	H-loop/switch region; other site
467705001651	Bacterial ABC transporter protein EcsB; Region: EcsB; pfam05975
467705001652	Thiamine kinase and related kinases [Coenzyme transport and metabolism]; Region: ycfN; COG0510
467705001653	Phosphotransferase enzyme family; Region: APH; pfam01636
467705001654	active site
467705001655	ATP binding site [chemical binding]; other site
467705001656	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
467705001657	S-adenosylmethionine binding site [chemical binding]; other site
467705001658	ribosome maturation protein RimP; Reviewed; Region: PRK00092
467705001659	Sm and related proteins; Region: Sm_like; cl00259
467705001660	Bacillus subtilis YxlS-like, C-terminal domain; Region: YlxS_C; cd01734
467705001661	putative oligomer interface [polypeptide binding]; other site
467705001662	putative RNA binding site [nucleotide binding]; other site
467705001663	transcription elongation factor NusA; Provisional; Region: nusA; PRK12327
467705001664	NusA N-terminal domain; Region: NusA_N; pfam08529
467705001665	S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455
467705001666	RNA binding site [nucleotide binding]; other site
467705001667	homodimer interface [polypeptide binding]; other site
467705001668	NusA-like KH domain; Region: KH_5; pfam13184
467705001669	NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134
467705001670	G-X-X-G motif; other site
467705001671	Ylxr homologs; group of conserved hypothetical bacterial proteins of unknown function; structure revealed putative RNA binding cleft; proteins are encoded by an operon that includes other proteins involved in transcription and/or translation; Region: YlxR; cd00279
467705001672	putative RNA binding cleft [nucleotide binding]; other site
467705001673	hypothetical protein; Provisional; Region: PRK07283
467705001674	Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760
467705001675	translation initiation factor IF-2; Validated; Region: infB; PRK05306
467705001676	Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760
467705001677	Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887
467705001678	G1 box; other site
467705001679	putative GEF interaction site [polypeptide binding]; other site
467705001680	GTP/Mg2+ binding site [chemical binding]; other site
467705001681	Switch I region; other site
467705001682	G2 box; other site
467705001683	G3 box; other site
467705001684	Switch II region; other site
467705001685	G4 box; other site
467705001686	G5 box; other site
467705001687	This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702
467705001688	Translation-initiation factor 2; Region: IF-2; pfam11987
467705001689	mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692
467705001690	ribosome-binding factor A; Validated; Region: rbfA; PRK00521
467705001691	Na+/phosphate symporter [Inorganic ion transport and metabolism]; Region: NptA; COG1283
467705001692	Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690
467705001693	Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690
467705001694	PhoU domain; Region: PhoU; pfam01895
467705001695	PhoU domain; Region: PhoU; pfam01895
467705001696	N-acetylglucosamine-6-phosphate deacetylase [Carbohydrate transport and metabolism]; Region: NagA; COG1820
467705001697	N-acetylglucosamine-6-phosphate deacetylase, NagA, catalyzes the hydrolysis of the N-acetyl group of N-acetyl-glucosamine-6-phosphate (GlcNAc-6-P) to glucosamine 6-phosphate and acetate. This is the first committed step in the biosynthetic pathway to...; Region: NagA; cd00854
467705001698	active site
467705001699	dimer interface [polypeptide binding]; other site
467705001700	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
467705001701	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
467705001702	active site
467705001703	catalytic tetrad [active]
467705001704	Acetyltransferases [General function prediction only]; Region: RimI; COG0456
467705001705	Type I site-specific restriction-modification system, R (restriction) subunit and related helicases [Defense mechanisms]; Region: COG0610
467705001706	Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; pfam04313
467705001707	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
467705001708	ATP binding site [chemical binding]; other site
467705001709	putative Mg++ binding site [ion binding]; other site
467705001710	Domain of unknown function (DUF1837); Region: DUF1837; pfam08878
467705001711	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
467705001712	Superfamily II helicase [General function prediction only]; Region: COG1204
467705001713	ATP binding site [chemical binding]; other site
467705001714	putative Mg++ binding site [ion binding]; other site
467705001715	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cl17351
467705001716	Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732
467705001717	Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420
467705001718	Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420
467705001719	Protein of unknown function (DUF4238); Region: DUF4238; pfam14022
467705001720	HsdM N-terminal domain; Region: HsdM_N; pfam12161
467705001721	N-6 DNA Methylase; Region: N6_Mtase; pfam02384
467705001722	Methyltransferase domain; Region: Methyltransf_26; pfam13659
467705001723	Plasmid maintenance system killer protein; Region: Plasmid_killer; cl01422
467705001724	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
467705001725	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
467705001726	non-specific DNA binding site [nucleotide binding]; other site
467705001727	salt bridge; other site
467705001728	sequence-specific DNA binding site [nucleotide binding]; other site
467705001729	Domain of unknown function (DUF955); Region: DUF955; pfam06114
467705001730	conserved hypothetical protein; Region: TIGR02328
467705001731	Pyrimidine dimer DNA glycosylase; Region: Pyr_excise; pfam03013
467705001732	ethanol-active dehydrogenase/acetaldehyde-active reductase; Provisional; Region: PRK09422
467705001733	Cinnamyl alcohol dehydrogenases (CAD); Region: CAD3; cd08297
467705001734	NAD binding site [chemical binding]; other site
467705001735	substrate binding site [chemical binding]; other site
467705001736	catalytic Zn binding site [ion binding]; other site
467705001737	tetramer interface [polypeptide binding]; other site
467705001738	structural Zn binding site [ion binding]; other site
467705001739	Gram-positive signal peptide, YSIRK family; Region: YSIRK_signal; TIGR01168
467705001740	Flagellar hook-length control protein FliK; Region: Flg_hook; cl17777
467705001741	Peptidase S8 family domain in Streptococcal C5a peptidases; Region: Peptidases_S8_C5a_Peptidase; cd07475
467705001742	putative active site [active]
467705001743	catalytic triad [active]
467705001744	PA_C5a_like: Protease-associated domain containing proteins like Streptococcus pyogenes C5a peptidase. This group contains various PA domain-containing proteins similar to S. pyogenes C5a, including, i) Vpr, a minor extracellular serine protease from...; Region: PA_C5a_like; cd02133
467705001745	PA/protease domain interface [polypeptide binding]; other site
467705001746	putative integrin binding motif; other site
467705001747	Peptidase S8 family domain in Streptococcal C5a peptidases; Region: Peptidases_S8_C5a_Peptidase; cd07475
467705001748	Fn3-like domain (DUF1034); Region: DUF1034; pfam06280
467705001749	Class II Glycyl-tRNA synthetase (GlyRS) alpha subunit core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes and in arabidopsis. It is responsible for the...; Region: GlyRS_alpha_core; cd00733
467705001750	dimer interface [polypeptide binding]; other site
467705001751	motif 1; other site
467705001752	active site
467705001753	motif 2; other site
467705001754	motif 3; other site
467705001755	glycyl-tRNA synthetase subunit beta; Validated; Region: glyS; PRK01233
467705001756	DALR anticodon binding domain; Region: DALR_1; pfam05746
467705001757	hypothetical protein; Provisional; Region: PRK02539
467705001758	Protein of unknown function (DUF3278); Region: DUF3278; pfam11683
467705001759	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
467705001760	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
467705001761	non-specific DNA binding site [nucleotide binding]; other site
467705001762	salt bridge; other site
467705001763	sequence-specific DNA binding site [nucleotide binding]; other site
467705001764	Predicted S-adenosylmethionine-dependent methyltransferase involved in cell envelope biogenesis [Cell envelope biogenesis, outer membrane]; Region: COG0275
467705001765	MraW methylase family; Region: Methyltransf_5; pfam01795
467705001766	Cell division protein FtsL; Region: FtsL; cl11433
467705001767	Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768
467705001768	Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717
467705001769	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905
467705001770	PASTA domain of PBP2x-like proteins, first repeat. Penicillin-binding proteins (PBPs) are the major targets for beta-lactam antibiotics, like penicillins and cephalosporins. Beta-lactam antibiotics specifically inhibit transpeptidase activity by...; Region: PASTA_Pbp2x-like_1; cd06576
467705001771	PASTA domain of PBP2x-like proteins, second repeat. Penicillin-binding proteins (PBPs) are the major targets for beta-lactam antibiotics, like penicillins and cephalosporins. Beta-lactam antibiotics specifically inhibit transpeptidase activity by...; Region: PASTA_Pbp2x-like_2; cd06575
467705001772	phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108
467705001773	Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852
467705001774	Mg++ binding site [ion binding]; other site
467705001775	putative catalytic motif [active]
467705001776	putative substrate binding site [chemical binding]; other site
467705001777	DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker  B motif; Region: DEADc; cd00268
467705001778	DEAD-like helicases superfamily; Region: DEXDc; smart00487
467705001779	ATP binding site [chemical binding]; other site
467705001780	Mg++ binding site [ion binding]; other site
467705001781	motif III; other site
467705001782	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
467705001783	nucleotide binding region [chemical binding]; other site
467705001784	ATP-binding site [chemical binding]; other site
467705001785	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
467705001786	dimer interface [polypeptide binding]; other site
467705001787	conserved gate region; other site
467705001788	putative PBP binding loops; other site
467705001789	ABC-ATPase subunit interface; other site
467705001790	ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126
467705001791	ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262
467705001792	Walker A/P-loop; other site
467705001793	ATP binding site [chemical binding]; other site
467705001794	Q-loop/lid; other site
467705001795	ABC transporter signature motif; other site
467705001796	Walker B; other site
467705001797	D-loop; other site
467705001798	H-loop/switch region; other site
467705001799	Protein of unknown function (DUF4059); Region: DUF4059; pfam13268
467705001800	thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292
467705001801	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
467705001802	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
467705001803	nicotinate phosphoribosyltransferase; Validated; Region: PRK09243
467705001804	Nicotinate phosphoribosyltransferase (NAPRTase), subgroup A. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting, reaction...; Region: NAPRTase_A; cd01570
467705001805	active site
467705001806	NAD synthase [Coenzyme metabolism]; Region: NadE; COG0171
467705001807	NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553
467705001808	homodimer interface [polypeptide binding]; other site
467705001809	NAD binding pocket [chemical binding]; other site
467705001810	ATP binding pocket [chemical binding]; other site
467705001811	Mg binding site [ion binding]; other site
467705001812	active-site loop [active]
467705001813	Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670
467705001814	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
467705001815	Peptidase C1B subfamily (MEROPS database nomenclature); composed of eukaryotic bleomycin hydrolases (BH) and bacterial aminopeptidases C (pepC). The proteins of this subfamily contain a large insert relative to the C1A peptidase (papain) subfamily. BH is...; Region: Peptidase_C1B; cd00585
467705001816	trimer interface [polypeptide binding]; other site
467705001817	active site
467705001818	G bulge; other site
467705001819	Transglycosylase; Region: Transgly; pfam00912
467705001820	penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074
467705001821	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760
467705001822	Holliday junction-specific endonuclease; Reviewed; Region: recU; PRK02234
467705001823	hypothetical protein; Provisional; Region: PRK13660
467705001824	cell division protein GpsB; Provisional; Region: PRK14127
467705001825	DivIVA domain; Region: DivI1A_domain; TIGR03544
467705001826	Predicted N6-adenine-specific DNA methylase [DNA replication, recombination, and repair]; Region: COG0116
467705001827	THUMP domain associated with S-adenosylmethionine-dependent methyltransferases; Region: THUMP_AdoMetMT; cd11715
467705001828	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173
467705001829	S-ribosylhomocysteinase; Provisional; Region: PRK02260
467705001830	hypothetical protein; Provisional; Region: PRK00106
467705001831	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
467705001832	Zn2+ binding site [ion binding]; other site
467705001833	Mg2+ binding site [ion binding]; other site
467705001834	Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194
467705001835	Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071
467705001836	catalytic site [active]
467705001837	G-X2-G-X-G-K; other site
467705001838	DNA-directed RNA polymerase subunit omega; Reviewed; Region: rpoZ; PRK00392
467705001839	Primosomal protein N' (replication factor Y) - superfamily II helicase [DNA replication, recombination, and repair]; Region: PriA; COG1198
467705001840	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
467705001841	ATP binding site [chemical binding]; other site
467705001842	putative Mg++ binding site [ion binding]; other site
467705001843	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
467705001844	ATP-binding site [chemical binding]; other site
467705001845	methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005
467705001846	Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646
467705001847	putative active site [active]
467705001848	substrate binding site [chemical binding]; other site
467705001849	putative cosubstrate binding site; other site
467705001850	catalytic site [active]
467705001851	C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704
467705001852	substrate binding site [chemical binding]; other site
467705001853	16S rRNA methyltransferase B; Provisional; Region: PRK14902
467705001854	NusB family; Region: NusB; pfam01029
467705001855	putative RNA binding site [nucleotide binding]; other site
467705001856	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
467705001857	S-adenosylmethionine binding site [chemical binding]; other site
467705001858	Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143
467705001859	active site
467705001860	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
467705001861	Catalytic domain of Protein Kinases; Region: PKc; cd00180
467705001862	active site
467705001863	ATP binding site [chemical binding]; other site
467705001864	substrate binding site [chemical binding]; other site
467705001865	activation loop (A-loop); other site
467705001866	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2815
467705001867	PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577
467705001868	PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577
467705001869	Predicted membrane protein [Function unknown]; Region: COG4758
467705001870	Cell wall-active antibiotics response protein (DUF2154); Region: DUF2154; pfam09922
467705001871	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585
467705001872	Histidine kinase; Region: HisKA_3; pfam07730
467705001873	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
467705001874	ATP binding site [chemical binding]; other site
467705001875	Mg2+ binding site [ion binding]; other site
467705001876	G-X-G motif; other site
467705001877	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
467705001878	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
467705001879	active site
467705001880	phosphorylation site [posttranslational modification]
467705001881	intermolecular recognition site; other site
467705001882	dimerization interface [polypeptide binding]; other site
467705001883	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
467705001884	DNA binding residues [nucleotide binding]
467705001885	dimerization interface [polypeptide binding]; other site
467705001886	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
467705001887	haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282
467705001888	active site
467705001889	motif I; other site
467705001890	motif II; other site
467705001891	haloacid dehalogenase-like hydrolase; Region: HAD; cl17202
467705001892	Peptidyl-prolyl cis-trans isomerase (rotamase) - cyclophilin family [Posttranslational modification, protein turnover, chaperones]; Region: PpiB; COG0652
467705001893	active site
467705001894	Predicted RNA binding protein (contains ribosomal protein S1 domain) [Translation, ribosomal structure and biogenesis]; Region: VacB; COG1098
467705001895	S1_RPS1_repeat_hs4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_hs4; cd05692
467705001896	RNA binding site [nucleotide binding]; other site
467705001897	Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031
467705001898	CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561
467705001899	dimer interface [polypeptide binding]; other site
467705001900	pyridoxal 5'-phosphate binding site [chemical binding]; other site
467705001901	catalytic residue [active]
467705001902	Uncharacterized conserved protein [Function unknown]; Region: COG1739
467705001903	Uncharacterized protein family UPF0029; Region: UPF0029; pfam01205
467705001904	Domain of unknown function (DUF1949); Region: DUF1949; pfam09186
467705001905	Superfamily II DNA/RNA helicase required for DNA uptake (late competence protein) [DNA replication, recombination, and repair]; Region: comFA; COG4098
467705001906	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
467705001907	ATP binding site [chemical binding]; other site
467705001908	putative Mg++ binding site [ion binding]; other site
467705001909	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
467705001910	nucleotide binding region [chemical binding]; other site
467705001911	ATP-binding site [chemical binding]; other site
467705001912	Predicted amidophosphoribosyltransferases [General function prediction only]; Region: ComFC; COG1040
467705001913	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
467705001914	active site
467705001915	RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY,  is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552
467705001916	30S subunit binding site; other site
467705001917	Staphylococcal protein of unknown function (DUF960); Region: DUF960; pfam06124
467705001918	hypothetical protein; Provisional; Region: PRK13662
467705001919	recombination regulator RecX; Provisional; Region: recX; PRK14135
467705001920	Phosphotransferase enzyme family; Region: APH; pfam01636
467705001921	Aminoglycoside 3'-phosphotransferase (APH). The APH subfamily is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs), RIO kinases, actin-fragmin...; Region: APH; cd05150
467705001922	active site
467705001923	ATP binding site [chemical binding]; other site
467705001924	antibiotic binding site [chemical binding]; other site
467705001925	TRAM domain; Region: TRAM; pfam01938
467705001926	SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase [Translation, ribosomal structure and biogenesis]; Region: TrmA; COG2265
467705001927	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
467705001928	S-adenosylmethionine binding site [chemical binding]; other site
467705001929	Glycerol uptake facilitator and related permeases (Major Intrinsic Protein Family) [Carbohydrate transport and metabolism]; Region: GlpF; COG0580
467705001930	amphipathic channel; other site
467705001931	Asn-Pro-Ala signature motifs; other site
467705001932	Glycerol-3-phosphate dehydrogenase [Energy production and conversion]; Region: GlpA; COG0578
467705001933	glycerol kinase; Provisional; Region: glpK; PRK00047
467705001934	Escherichia coli glycerol kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_EcGK_like; cd07786
467705001935	N- and C-terminal domain interface [polypeptide binding]; other site
467705001936	active site
467705001937	MgATP binding site [chemical binding]; other site
467705001938	catalytic site [active]
467705001939	metal binding site [ion binding]; metal-binding site
467705001940	glycerol binding site [chemical binding]; other site
467705001941	homotetramer interface [polypeptide binding]; other site
467705001942	homodimer interface [polypeptide binding]; other site
467705001943	FBP binding site [chemical binding]; other site
467705001944	protein IIAGlc interface [polypeptide binding]; other site
467705001945	Mga helix-turn-helix domain; Region: Mga; pfam05043
467705001946	PTS_IIB: subunit IIB of enzyme II (EII) is the central energy-coupling domain of the phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In the multienzyme PTS complex, EII is a carbohydrate-specific permease consisting of two cytoplasmic...; Region: PTS_IIB; cl10014
467705001947	Domain of unknown function (DUF1858); Region: DUF1858; pfam08984
467705001948	Uncharacterized conserved protein [Function unknown]; Region: COG2461
467705001949	Family of unknown function (DUF438); Region: DUF438; pfam04282
467705001950	Hemerythrin HHE cation binding domain; Region: Hemerythrin; pfam01814
467705001951	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
467705001952	putative active site [active]
467705001953	heme pocket [chemical binding]; other site
467705001954	Domain of unknown function (DUF1912); Region: DUF1912; pfam08930
467705001955	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
467705001956	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
467705001957	Coenzyme A binding pocket [chemical binding]; other site
467705001958	valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729
467705001959	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
467705001960	active site
467705001961	HIGH motif; other site
467705001962	nucleotide binding site [chemical binding]; other site
467705001963	Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603
467705001964	catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817
467705001965	active site
467705001966	KMSKS motif; other site
467705001967	Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962
467705001968	tRNA binding surface [nucleotide binding]; other site
467705001969	anticodon binding site; other site
467705001970	Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458
467705001971	Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c_3; pfam13589
467705001972	Mg2+ binding site [ion binding]; other site
467705001973	G-X-G motif; other site
467705001974	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
467705001975	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
467705001976	ATP binding site [chemical binding]; other site
467705001977	G-X-G motif; other site
467705001978	Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315
467705001979	DNA-methyltransferase (dcm); Region: dcm; TIGR00675
467705001980	cofactor binding site; other site
467705001981	DNA binding site [nucleotide binding]
467705001982	substrate interaction site [chemical binding]; other site
467705001983	YolD-like protein; Region: YolD; pfam08863
467705001984	DNA polymerase IV; Reviewed; Region: PRK03103
467705001985	umuC subunit of DNA Polymerase V; Region: PolY_Pol_V_umuC; cd01700
467705001986	active site
467705001987	DNA binding site [nucleotide binding]
467705001988	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
467705001989	sequence-specific DNA binding site [nucleotide binding]; other site
467705001990	Predicted transcriptional regulator [Transcription]; Region: COG2932
467705001991	salt bridge; other site
467705001992	Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529
467705001993	Catalytic site [active]
467705001994	YcxB-like protein; Region: YcxB; pfam14317
467705001995	Conserved hypothetical protein 95; Region: Cons_hypoth95; pfam03602
467705001996	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
467705001997	S-adenosylmethionine binding site [chemical binding]; other site
467705001998	phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168
467705001999	Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163
467705002000	active site
467705002001	(T/H)XGH motif; other site
467705002002	Predicted secreted protein containing a PDZ domain [Signal transduction mechanisms]; Region: SdrC; COG3480
467705002003	PDZ domain, also called DHR (Dlg homologous region) or GLGF (after a conserved sequence motif). Many PDZ domains bind C-terminal polypeptides, though binding to internal (non-C-terminal) polypeptides and even to lipids has been demonstrated; Region: PDZ; cl00117
467705002004	protein binding site [polypeptide binding]; other site
467705002005	Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362
467705002006	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4470
467705002007	ribosomal RNA large subunit methyltransferase N; Provisional; Region: PRK14455
467705002008	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
467705002009	FeS/SAM binding site; other site
467705002010	VanZ like family; Region: VanZ; pfam04892
467705002011	tryptophan synthase, beta subunit; Region: trpB; TIGR00263
467705002012	Tryptophan synthase-beta:  Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446
467705002013	pyridoxal 5'-phosphate binding site [chemical binding]; other site
467705002014	catalytic residue [active]
467705002015	anthranilate synthase component I; Provisional; Region: PRK13570
467705002016	Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715
467705002017	chorismate binding enzyme; Region: Chorismate_bind; pfam00425
467705002018	para-aminobenzoate synthase component II; Provisional; Region: PRK08857
467705002019	Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743
467705002020	glutamine binding [chemical binding]; other site
467705002021	catalytic triad [active]
467705002022	anthranilate phosphoribosyltransferase; Provisional; Region: trpD; PRK00188
467705002023	Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885
467705002024	Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591
467705002025	Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331
467705002026	active site
467705002027	ribulose/triose binding site [chemical binding]; other site
467705002028	phosphate binding site [ion binding]; other site
467705002029	substrate (anthranilate) binding pocket [chemical binding]; other site
467705002030	product (indole) binding pocket [chemical binding]; other site
467705002031	Phosphoribosylanthranilate isomerase (PRAI) catalyzes the fourth step of the tryptophan biosynthesis, the conversion of N-(5'- phosphoribosyl)-anthranilate (PRA) to 1-(o-carboxyphenylamino)- 1-deoxyribulose 5-phosphate (CdRP). Most PRAIs are...; Region: PRAI; cd00405
467705002032	active site
467705002033	tryptophan synthase, beta subunit; Region: trpB; TIGR00263
467705002034	Tryptophan synthase-beta:  Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446
467705002035	pyridoxal 5'-phosphate binding site [chemical binding]; other site
467705002036	catalytic residue [active]
467705002037	Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724
467705002038	tryptophan synthase alpha subunit; Provisional; Region: trpA; CHL00200
467705002039	substrate binding site [chemical binding]; other site
467705002040	active site
467705002041	catalytic residues [active]
467705002042	heterodimer interface [polypeptide binding]; other site
467705002043	Type II secretory pathway, prepilin signal peptidase PulO and related peptidases [Cell motility and secretion / Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: PulO; COG1989
467705002044	Bacterial Peptidase A24 N-terminal domain; Region: DiS_P_DiS; pfam06750
467705002045	DNA-binding ferritin-like protein (oxidative damage protectant) [Inorganic ion transport and metabolism]; Region: Dps; COG0783
467705002046	DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043
467705002047	dimerization interface [polypeptide binding]; other site
467705002048	DPS ferroxidase diiron center [ion binding]; other site
467705002049	ion pore; other site
467705002050	Bacterial protein of unknown function (DUF910); Region: DUF910; pfam06014
467705002051	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158
467705002052	active site residue [active]
467705002053	16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187
467705002054	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cl09940
467705002055	RNA binding surface [nucleotide binding]; other site
467705002056	Pseudouridine synthase, Escherichia coli RsuA like; Region: PseudoU_synth_RsuA; cd02553
467705002057	active site
467705002058	uracil binding [chemical binding]; other site
467705002059	Predicted membrane GTPase involved in stress response [Signal transduction mechanisms]; Region: TypA; COG1217
467705002060	Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891
467705002061	G1 box; other site
467705002062	putative GEF interaction site [polypeptide binding]; other site
467705002063	GTP/Mg2+ binding site [chemical binding]; other site
467705002064	Switch I region; other site
467705002065	G2 box; other site
467705002066	G3 box; other site
467705002067	Switch II region; other site
467705002068	G4 box; other site
467705002069	G5 box; other site
467705002070	BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu.  BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691
467705002071	BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants.  BipA is a highly...; Region: BipA_TypA_C; cd03710
467705002072	Protein of unknown function (DUF3165); Region: DUF3165; pfam11364
467705002073	UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK02472
467705002074	Alanine dehydrogenase/PNT, C-terminal domain; Region: AlaDh_PNT_C; smart01002
467705002075	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
467705002076	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
467705002077	undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726
467705002078	MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785
467705002079	active site
467705002080	homodimer interface [polypeptide binding]; other site
467705002081	POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478
467705002082	Cell division protein FtsQ; Region: FtsQ; pfam03799
467705002083	Cell division ATPase FtsA [Cell division and chromosome partitioning]; Region: ftsA; COG0849
467705002084	Cell division protein FtsA; Region: FtsA; smart00842
467705002085	Cell division protein FtsA; Region: FtsA; pfam14450
467705002086	Domain of unknown function (DUF3484); Region: DUF3484; pfam11983
467705002087	cell division protein FtsZ; Validated; Region: PRK09330
467705002088	FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes.  FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201
467705002089	nucleotide binding site [chemical binding]; other site
467705002090	SulA interaction site; other site
467705002091	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, YBL036c-like proteins; Region: PLPDE_III_YBL036c_like; cd00635
467705002092	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
467705002093	catalytic residue [active]
467705002094	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1799
467705002095	YGGT family; Region: YGGT; pfam02325
467705002096	Uncharacterized conserved protein, contains S4-like domain [Function unknown]; Region: COG2302
467705002097	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
467705002098	RNA binding surface [nucleotide binding]; other site
467705002099	DivIVA protein; Region: DivIVA; pfam05103
467705002100	DivIVA domain; Region: DivI1A_domain; TIGR03544
467705002101	isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK05743
467705002102	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
467705002103	active site
467705002104	HIGH motif; other site
467705002105	nucleotide binding site [chemical binding]; other site
467705002106	catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818
467705002107	active site
467705002108	KMSKS motif; other site
467705002109	Anticodon-binding domain of bacterial and eukaryotic mitochondrial isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_BEm; cd07960
467705002110	tRNA binding surface [nucleotide binding]; other site
467705002111	anticodon binding site; other site
467705002112	Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827
467705002113	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
467705002114	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
467705002115	putative DNA binding site [nucleotide binding]; other site
467705002116	putative Zn2+ binding site [ion binding]; other site
467705002117	Domain of unknown function (DUF1827); Region: DUF1827; pfam08860
467705002118	Contains a crystal structure of the Nudix hydrolase from Enterococcus faecalis, which has an unknown function. In general, members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes...; Region: Nudix_Hydrolase_25; cd04684
467705002119	nudix motif; other site
467705002120	Predicted transcriptional regulator [Transcription]; Region: COG2378
467705002121	HTH domain; Region: HTH_11; pfam08279
467705002122	WYL domain; Region: WYL; pfam13280
467705002123	GyrI-like small molecule binding domain; Region: GyrI-like; cl01368
467705002124	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
467705002125	ATPases associated with a variety of cellular activities; Region: AAA; smart00382
467705002126	Walker A motif; other site
467705002127	ATP binding site [chemical binding]; other site
467705002128	Walker B motif; other site
467705002129	arginine finger; other site
467705002130	UvrB/uvrC motif; Region: UVR; pfam02151
467705002131	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
467705002132	ATPases associated with a variety of cellular activities; Region: AAA; smart00382
467705002133	Walker A motif; other site
467705002134	ATP binding site [chemical binding]; other site
467705002135	Walker B motif; other site
467705002136	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431
467705002137	Protein of unknown function (DUF1797); Region: DUF1797; cl11550
467705002138	bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK14179
467705002139	Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763
467705002140	NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080
467705002141	homodimer interface [polypeptide binding]; other site
467705002142	NADP binding site [chemical binding]; other site
467705002143	substrate binding site [chemical binding]; other site
467705002144	HAD-superfamily hydrolase, subfamily IIB; Region: HAD-SF-IIB; TIGR01484
467705002145	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
467705002146	active site
467705002147	motif I; other site
467705002148	motif II; other site
467705002149	B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171
467705002150	putative substrate binding site [chemical binding]; other site
467705002151	putative ATP binding site [chemical binding]; other site
467705002152	exodeoxyribonuclease VII large subunit; Reviewed; Region: xseA; PRK00286
467705002153	ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489
467705002154	generic binding surface II; other site
467705002155	generic binding surface I; other site
467705002156	exodeoxyribonuclease VII small subunit; Provisional; Region: PRK00977
467705002157	Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142
467705002158	Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685
467705002159	substrate binding pocket [chemical binding]; other site
467705002160	chain length determination region; other site
467705002161	substrate-Mg2+ binding site; other site
467705002162	catalytic residues [active]
467705002163	aspartate-rich region 1; other site
467705002164	active site lid residues [active]
467705002165	aspartate-rich region 2; other site
467705002166	Predicted rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: COG1189
467705002167	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cl09940
467705002168	RNA binding surface [nucleotide binding]; other site
467705002169	FtsJ-like methyltransferase; Region: FtsJ; pfam01728
467705002170	Arginine repressor [Transcription]; Region: ArgR; COG1438
467705002171	Arginine repressor, DNA binding domain; Region: Arg_repressor; pfam01316
467705002172	Arginine repressor, C-terminal domain; Region: Arg_repressor_C; pfam02863
467705002173	ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: RecN; COG0497
467705002174	ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241
467705002175	Walker A/P-loop; other site
467705002176	ATP binding site [chemical binding]; other site
467705002177	Q-loop/lid; other site
467705002178	ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241
467705002179	ABC transporter signature motif; other site
467705002180	Walker B; other site
467705002181	D-loop; other site
467705002182	H-loop/switch region; other site
467705002183	phosphoprotein phosphatases of the metallophosphatase superfamily, metallophosphatase domain; Region: MPP_PPP_family; cd00144
467705002184	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
467705002185	active site
467705002186	metal binding site [ion binding]; metal-binding site
467705002187	EDD domain protein, DegV family; Region: DegV; TIGR00762
467705002188	Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645
467705002189	Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591
467705002190	IHF dimer interface [polypeptide binding]; other site
467705002191	IHF - DNA interface [nucleotide binding]; other site
467705002192	Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153
467705002193	metal binding site 2 [ion binding]; metal-binding site
467705002194	putative DNA binding helix; other site
467705002195	metal binding site 1 [ion binding]; metal-binding site
467705002196	dimer interface [polypeptide binding]; other site
467705002197	structural Zn2+ binding site [ion binding]; other site
467705002198	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
467705002199	catalytic core [active]
467705002200	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
467705002201	hypothetical protein; Provisional; Region: PRK13672
467705002202	Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702
467705002203	PhoH-like protein; Region: PhoH; pfam02562
467705002204	fimbrial isopeptide formation D2 domain; Region: RrgB_K2N_iso_D2; TIGR04226
467705002205	LPXTG-motif cell wall anchor domain; Region: LPXTG_anchor; TIGR01167
467705002206	Alanine dehydrogenase [Amino acid transport and metabolism]; Region: Ald; COG0686
467705002207	Alanine dehydrogenase NAD-binding and catalytic domains; Region: L-AlaDH; cd05305
467705002208	hexamer interface [polypeptide binding]; other site
467705002209	ligand binding site [chemical binding]; other site
467705002210	putative active site [active]
467705002211	NAD(P) binding site [chemical binding]; other site
467705002212	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
467705002213	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
467705002214	metal-binding heat shock protein; Provisional; Region: PRK00016
467705002215	Diacylglycerol kinase [Cell envelope biogenesis, outer membrane]; Region: DgkA; COG0818
467705002216	GTPase Era; Reviewed; Region: era; PRK00089
467705002217	E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163
467705002218	G1 box; other site
467705002219	GTP/Mg2+ binding site [chemical binding]; other site
467705002220	Switch I region; other site
467705002221	G2 box; other site
467705002222	Switch II region; other site
467705002223	G3 box; other site
467705002224	G4 box; other site
467705002225	G5 box; other site
467705002226	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
467705002227	formamidopyrimidine/5-formyluracil/ 5-hydroxymethyluracil DNA glycosylase; Validated; Region: PRK01103
467705002228	N-terminal domain of Escherichia coli Fpg1/MutM and related bacterial DNA glycosylases; Region: EcFpg-like_N; cd08966
467705002229	DNA binding site [nucleotide binding]
467705002230	catalytic residue [active]
467705002231	H2TH interface [polypeptide binding]; other site
467705002232	putative catalytic residues [active]
467705002233	turnover-facilitating residue; other site
467705002234	intercalation triad [nucleotide binding]; other site
467705002235	8OG recognition residue [nucleotide binding]; other site
467705002236	putative reading head residues; other site
467705002237	Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831
467705002238	Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827
467705002239	Dephospho-CoA kinase [Coenzyme metabolism]; Region: CoaE; COG0237
467705002240	Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022
467705002241	CoA-binding site [chemical binding]; other site
467705002242	ATP-binding [chemical binding]; other site
467705002243	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
467705002244	drug efflux system protein MdtG; Provisional; Region: PRK09874
467705002245	putative substrate translocation pore; other site
467705002246	ribonuclease R; Region: RNase_R; TIGR02063
467705002247	Ribonuclease B OB domain; Region: OB_RNB; pfam08206
467705002248	RNB domain; Region: RNB; pfam00773
467705002249	S1_RNase_R: RNase R C-terminal S1 domain. RNase R is a processive 3' to 5' exoribonuclease, which is a homolog of RNase II. RNase R degrades RNA with secondary structure having a 3' overhang of at least 7 nucleotides. RNase R and PNPase...; Region: S1_RNase_R; cd04471
467705002250	RNA binding site [nucleotide binding]; other site
467705002251	Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294
467705002252	SmpB-tmRNA interface; other site
467705002253	Peptidase family C69; Region: Peptidase_C69; cl17793
467705002254	tellurite resistance protein TehB; Provisional; Region: PRK12335
467705002255	Uncharacterized protein/domain, possibly involved in tellurite resistance [Inorganic ion transport and metabolism]; Region: TehB; COG3615
467705002256	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
467705002257	S-adenosylmethionine binding site [chemical binding]; other site
467705002258	Peptidase family C69; Region: Peptidase_C69; cl17793
467705002259	Protease prsW family; Region: PrsW-protease; pfam13367
467705002260	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
467705002261	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
467705002262	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
467705002263	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
467705002264	Walker A/P-loop; other site
467705002265	ATP binding site [chemical binding]; other site
467705002266	Q-loop/lid; other site
467705002267	ABC transporter signature motif; other site
467705002268	Walker B; other site
467705002269	D-loop; other site
467705002270	H-loop/switch region; other site
467705002271	ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577
467705002272	FtsX-like permease family; Region: FtsX; pfam02687
467705002273	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
467705002274	ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577
467705002275	FtsX-like permease family; Region: FtsX; pfam02687
467705002276	Escherichia coli YfcE and related proteins, metallophosphatase domain; Region: MPP_YfcE; cd00841
467705002277	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
467705002278	active site
467705002279	metal binding site [ion binding]; metal-binding site
467705002280	homotetramer interface [polypeptide binding]; other site
467705002281	Predicted transcriptional regulator [Transcription]; Region: COG1959
467705002282	Transcriptional regulator; Region: Rrf2; pfam02082
467705002283	Putative stress-responsive transcriptional regulator [Transcription / Signal transduction mechanisms]; Region: PspC; COG1983
467705002284	HPr kinase/phosphorylase; Provisional; Region: PRK05428
467705002285	HPr Serine kinase N terminus; Region: Hpr_kinase_N; pfam02603
467705002286	HprK/P, the bifunctional histidine-containing protein kinase/phosphatase, controls the phosphorylation state of the phosphocarrier protein HPr and regulates the utilization of carbon sources by gram-positive bacteria. It catalyzes both the ATP-dependent...; Region: HprK_C; cd01918
467705002287	Hpr binding site; other site
467705002288	active site
467705002289	homohexamer subunit interaction site [polypeptide binding]; other site
467705002290	Prolipoprotein diacylglyceryl transferase; Region: LGT; pfam01790
467705002291	Uncharacterized protein containing a divergent version of the methyl-accepting chemotaxis-like domain [General function prediction only]; Region: COG4768
467705002292	YtxH-like protein; Region: YtxH; pfam12732
467705002293	Peptidase_C39 like family; Region: Peptidase_C39_2; pfam13529
467705002294	putative active site [active]
467705002295	Protein of unknown function (DUF3270); Region: DUF3270; pfam11674
467705002296	Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826
467705002297	TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186
467705002298	Peptidase family U32; Region: Peptidase_U32; pfam01136
467705002299	Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826
467705002300	Peptidase family U32; Region: Peptidase_U32; pfam01136
467705002301	Uncharacterized protein conserved in bacteria (DUF2128); Region: DUF2128; pfam09901
467705002302	BioY family; Region: BioY; pfam02632
467705002303	CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311
467705002304	substrate binding site [chemical binding]; other site
467705002305	THF binding site; other site
467705002306	zinc-binding site [ion binding]; other site
467705002307	Kynurenine formamidase [Amino acid transport and metabolism]; Region: COG1878
467705002308	glutathione reductase; Validated; Region: PRK06116
467705002309	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
467705002310	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
467705002311	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
467705002312	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
467705002313	HlyD family secretion protein; Region: HlyD_3; pfam13437
467705002314	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
467705002315	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
467705002316	Walker A/P-loop; other site
467705002317	ATP binding site [chemical binding]; other site
467705002318	Q-loop/lid; other site
467705002319	ABC transporter signature motif; other site
467705002320	Walker B; other site
467705002321	D-loop; other site
467705002322	H-loop/switch region; other site
467705002323	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
467705002324	ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577
467705002325	FtsX-like permease family; Region: FtsX; pfam02687
467705002326	lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484
467705002327	LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322
467705002328	dimer interface [polypeptide binding]; other site
467705002329	putative anticodon binding site; other site
467705002330	Lys_tRNA synthetase (LysRS) class II core domain. Class II LysRS is a dimer which attaches a lysine to the 3' OH group of ribose of the appropriate tRNA. Its assignment to class II aaRS is based upon its structure and the presence of three...; Region: LysRS_core; cd00775
467705002331	motif 1; other site
467705002332	active site
467705002333	motif 2; other site
467705002334	motif 3; other site
467705002335	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
467705002336	catalytic core [active]
467705002337	This CD includes cysteinyl-tRNA(Pro) deacylases from Haemophilus influenzae and Escherichia coli and other related bacterial proteins. These trans-acting, single-domain proteins are homologs of ProX and also the cis-acting prolyl-tRNA synthetase (ProRS)...; Region: YbaK_deacylase; cd00002
467705002338	putative deacylase active site [active]
467705002339	Predicted membrane protein [Function unknown]; Region: COG2035
467705002340	PlyB is a bacteriophage endolysin that displays potent lytic activity toward Bacillus anthracis.  PlyB has an N-terminal glycosyl hydrolase family 25 (GH25) catalytic domain and a C-terminal bacterial SH3-like domain, SH3b.  Both domains are required for...; Region: GH25_PlyB-like; cd06523
467705002341	Glycosyl hydrolases family 25; Region: Glyco_hydro_25; pfam01183
467705002342	active site
467705002343	Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per...; Region: GSH_Peroxidase; cd00340
467705002344	catalytic residues [active]
467705002345	dimer interface [polypeptide binding]; other site
467705002346	Bacterial cell division membrane protein [Cell division and chromosome partitioning]; Region: FtsW; COG0772
467705002347	phosphoenolpyruvate carboxylase; Reviewed; Region: PRK00009
467705002348	Phosphoenolpyruvate carboxylase [Energy production and conversion]; Region: Ppc; COG2352
467705002349	elongation factor Tu; Reviewed; Region: PRK00049
467705002350	Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884
467705002351	G1 box; other site
467705002352	GEF interaction site [polypeptide binding]; other site
467705002353	GTP/Mg2+ binding site [chemical binding]; other site
467705002354	Switch I region; other site
467705002355	G2 box; other site
467705002356	G3 box; other site
467705002357	Switch II region; other site
467705002358	G4 box; other site
467705002359	G5 box; other site
467705002360	EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697
467705002361	Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707
467705002362	Antibiotic Binding Site [chemical binding]; other site
467705002363	triosephosphate isomerase; Provisional; Region: PRK14567
467705002364	Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311
467705002365	substrate binding site [chemical binding]; other site
467705002366	dimer interface [polypeptide binding]; other site
467705002367	catalytic triad [active]
467705002368	UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072
467705002369	UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555
467705002370	hinge; other site
467705002371	active site
467705002372	DNA-directed RNA polymerase subunit beta; Region: EpuA; pfam11772
467705002373	DNA/RNA non-specific endonuclease; Region: Endonuclease_NS; smart00892
467705002374	DNA/RNA non-specific endonuclease; Region: Endonuclease_NS; pfam01223
467705002375	Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819
467705002376	Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+.  Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262
467705002377	Periplasmic binding protein; Region: Peripla_BP_2; pfam01497
467705002378	intersubunit interface [polypeptide binding]; other site
467705002379	ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120
467705002380	ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214
467705002381	Walker A/P-loop; other site
467705002382	ATP binding site [chemical binding]; other site
467705002383	Q-loop/lid; other site
467705002384	ABC transporter signature motif; other site
467705002385	Walker B; other site
467705002386	D-loop; other site
467705002387	H-loop/switch region; other site
467705002388	iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577
467705002389	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
467705002390	ABC-ATPase subunit  interface; other site
467705002391	dimer interface [polypeptide binding]; other site
467705002392	putative PBP binding regions; other site
467705002393	Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006
467705002394	Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321
467705002395	Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092
467705002396	active site
467705002397	catabolite control protein A; Region: ccpA; TIGR01481
467705002398	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
467705002399	DNA binding site [nucleotide binding]
467705002400	domain linker motif; other site
467705002401	Ligand-binding domain of the catabolite control protein A (CcpA), which functions as the major transcriptional regulator of carbon catabolite repression/regulation; Region: PBP1_CcpA_like; cd06298
467705002402	dimerization interface [polypeptide binding]; other site
467705002403	effector binding site; other site
467705002404	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
467705002405	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
467705002406	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
467705002407	This family is most closely related to the GT1 family of glycosyltransferases. UDP-glucose-diacylglycerol glucosyltransferase (UGDG; also known as 1,2-diacylglycerol 3-glucosyltransferase) catalyzes the transfer of glucose from UDP-glucose to 1; Region: GT1_UGDG_like; cd03817
467705002408	putative ADP-binding pocket [chemical binding]; other site
467705002409	threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK00413
467705002410	TGS _ThrRS_N:  ThrRS (threonyl-tRNA Synthetase)  is a class II tRNA synthetase that couples threonine to its cognate tRNA.  In addition to its catalytic and anticodon-binding domains, ThrRS has an N-terminal TGS domain, named after the ThrRS, GTPase, and...; Region: TGS_ThrRS_N; cd01667
467705002411	Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863
467705002412	Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771
467705002413	active site
467705002414	dimer interface [polypeptide binding]; other site
467705002415	motif 1; other site
467705002416	motif 2; other site
467705002417	motif 3; other site
467705002418	ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860
467705002419	anticodon binding site; other site
467705002420	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
467705002421	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
467705002422	active site
467705002423	phosphorylation site [posttranslational modification]
467705002424	intermolecular recognition site; other site
467705002425	dimerization interface [polypeptide binding]; other site
467705002426	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
467705002427	DNA binding site [nucleotide binding]
467705002428	phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966
467705002429	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
467705002430	putative active site [active]
467705002431	heme pocket [chemical binding]; other site
467705002432	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
467705002433	dimer interface [polypeptide binding]; other site
467705002434	phosphorylation site [posttranslational modification]
467705002435	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
467705002436	ATP binding site [chemical binding]; other site
467705002437	Mg2+ binding site [ion binding]; other site
467705002438	G-X-G motif; other site
467705002439	Metal-dependent hydrolases of the beta-lactamase superfamily I [General function prediction only]; Region: PhnP; COG1235
467705002440	Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220
467705002441	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2832
467705002442	ribonuclease III; Reviewed; Region: rnc; PRK00102
467705002443	RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593
467705002444	dimerization interface [polypeptide binding]; other site
467705002445	active site
467705002446	metal binding site [ion binding]; metal-binding site
467705002447	Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048
467705002448	dsRNA binding site [nucleotide binding]; other site
467705002449	chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168
467705002450	ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278
467705002451	Walker A/P-loop; other site
467705002452	ATP binding site [chemical binding]; other site
467705002453	Q-loop/lid; other site
467705002454	SMC proteins Flexible Hinge Domain; Region: SMC_hinge; smart00968
467705002455	ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278
467705002456	ABC transporter signature motif; other site
467705002457	Walker B; other site
467705002458	D-loop; other site
467705002459	H-loop/switch region; other site
467705002460	Predicted hydrolases of the HAD superfamily [General function prediction only]; Region: Cof; COG0561
467705002461	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
467705002462	active site
467705002463	motif I; other site
467705002464	motif II; other site
467705002465	haloacid dehalogenase-like hydrolase; Region: HAD; cl17202
467705002466	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
467705002467	haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282
467705002468	active site
467705002469	motif I; other site
467705002470	motif II; other site
467705002471	haloacid dehalogenase-like hydrolase; Region: HAD; cl17202
467705002472	signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416
467705002473	The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115
467705002474	P loop; other site
467705002475	GTP binding site [chemical binding]; other site
467705002476	glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722
467705002477	Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479
467705002478	Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781
467705002479	Predicted membrane protein [Function unknown]; Region: COG3689
467705002480	Predicted permeases [General function prediction only]; Region: COG0701
467705002481	Transcriptional accessory protein [Transcription]; Region: Tex; COG2183
467705002482	Tex-like protein N-terminal domain; Region: Tex_N; pfam09371
467705002483	Likely ribonuclease with RNase H fold; Region: YqgFc; smart00732
467705002484	S1_Tex: The C-terminal S1 domain of a transcription accessory factor called Tex, which has been characterized in Bordetella pertussis and Pseudomonas aeruginosa. The tex gene is essential in Bortella pertusis and is named for its role in toxin expression; Region: S1_Tex; cd05685
467705002485	RNA binding site [nucleotide binding]; other site
467705002486	hypothetical protein; Provisional; Region: PRK04351
467705002487	SprT homologues; Region: SprT; cl01182
467705002488	mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595
467705002489	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
467705002490	Predicted esterase [General function prediction only]; Region: COG0627
467705002491	S-formylglutathione hydrolase; Region: PLN02442
467705002492	Zinc-dependent metalloprotease, MMP_like subfamily. This group contains matrix metalloproteinases (MMPs), serralysins, and the astacin_like family of proteases; Region: ZnMc_MMP_like; cd04268
467705002493	active site
467705002494	M20 Peptidase Arginine utilization protein, RocB; Region: M20_ArgE_RocB; cd05654
467705002495	putative metal binding site [ion binding]; other site
467705002496	putative dimer interface [polypeptide binding]; other site
467705002497	ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555
467705002498	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
467705002499	Walker A/P-loop; other site
467705002500	ATP binding site [chemical binding]; other site
467705002501	Q-loop/lid; other site
467705002502	ABC transporter signature motif; other site
467705002503	Walker B; other site
467705002504	D-loop; other site
467705002505	H-loop/switch region; other site
467705002506	Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726
467705002507	Putative catalytic NodB homology domain of PgaB, IcaB, and similar proteins which consist of a deformed (beta/alpha)8 barrel fold with 5- or 6-strands; Region: CE4_NodB_like_5s_6s; cd10918
467705002508	putative active site [active]
467705002509	putative metal binding site [ion binding]; other site
467705002510	homoserine dehydrogenase; Provisional; Region: PRK06349
467705002511	Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447
467705002512	Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742
467705002513	ACT_HSDH_Hom CD includes the C-terminal ACT domain of the NAD(P)H-dependent, homoserine dehydrogenase (HSDH) and related domains; Region: ACT_HSDH-Hom; cd04881
467705002514	homoserine kinase; Provisional; Region: PRK01212
467705002515	GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288
467705002516	GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544
467705002517	UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK13905
467705002518	FAD binding domain; Region: FAD_binding_4; pfam01565
467705002519	UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873
467705002520	ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842
467705002521	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
467705002522	Walker A/P-loop; other site
467705002523	ATP binding site [chemical binding]; other site
467705002524	Q-loop/lid; other site
467705002525	ABC transporter signature motif; other site
467705002526	Walker B; other site
467705002527	D-loop; other site
467705002528	H-loop/switch region; other site
467705002529	TOBE domain; Region: TOBE_2; pfam08402
467705002530	ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555
467705002531	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
467705002532	dimer interface [polypeptide binding]; other site
467705002533	conserved gate region; other site
467705002534	putative PBP binding loops; other site
467705002535	ABC-ATPase subunit interface; other site
467705002536	ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177
467705002537	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
467705002538	dimer interface [polypeptide binding]; other site
467705002539	conserved gate region; other site
467705002540	putative PBP binding loops; other site
467705002541	ABC-ATPase subunit interface; other site
467705002542	Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687
467705002543	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199
467705002544	pyruvate phosphate dikinase; Provisional; Region: PRK09279
467705002545	Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326
467705002546	PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391
467705002547	PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896
467705002548	HTH domain; Region: HTH_11; pfam08279
467705002549	FOG: CBS domain [General function prediction only]; Region: COG0517
467705002550	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354
467705002551	PEP synthetase regulatory protein; Provisional; Region: PRK05339
467705002552	Firmicute fructose-1,6-bisphosphatase; Region: FBPase_2; pfam06874
467705002553	metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995
467705002554	Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104
467705002555	cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402
467705002556	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
467705002557	catalytic residue [active]
467705002558	thiamine biosynthesis protein ThiI; Provisional; Region: PRK01565
467705002559	THUMP domain of thiamine biosynthesis protein ThiI; Region: THUMP_ThiI; cd11716
467705002560	ThiI is required for thiazole synthesis in the thiamine biosynthesis pathway. It belongs to the Adenosine Nucleotide Hydrolysis suoerfamily and predicted to bind to Adenosine nucleotide; Region: ThiI; cd01712
467705002561	Ligand Binding Site [chemical binding]; other site
467705002562	Phospholipid methyltransferase; Region: PEMT; pfam04191
467705002563	50S ribosomal protein L21; Validated; Region: rplU; PRK05573
467705002564	Predicted ribosomal protein [Translation, ribosomal structure and biogenesis]; Region: COG2868
467705002565	50S ribosomal protein L27; Validated; Region: rpmA; PRK05435
467705002566	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158
467705002567	active site residue [active]
467705002568	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
467705002569	haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282
467705002570	active site
467705002571	motif I; other site
467705002572	motif II; other site
467705002573	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
467705002574	motif II; other site
467705002575	GTP-binding protein LepA; Provisional; Region: PRK05433
467705002576	LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890
467705002577	G1 box; other site
467705002578	putative GEF interaction site [polypeptide binding]; other site
467705002579	GTP/Mg2+ binding site [chemical binding]; other site
467705002580	Switch I region; other site
467705002581	G2 box; other site
467705002582	G3 box; other site
467705002583	Switch II region; other site
467705002584	G4 box; other site
467705002585	G5 box; other site
467705002586	lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699
467705002587	lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane.   LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709
467705002588	GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421
467705002589	Flagellin N-methylase; Region: FliB; pfam03692
467705002590	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
467705002591	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3708
467705002592	A predicted NlpC/p60-like peptidase; Region: BtrH; pfam14399
467705002593	Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various bacteriocins (mostly non-lantibiotic); Region: Peptidase_C39_like; cl00296
467705002594	putative active site [active]
467705002595	haloacid dehalogenase superfamily, subfamily IA, variant 1 with third motif having Dx(3-4)D or Dx(3-4)E; Region: HAD-SF-IA-v1; TIGR01549
467705002596	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
467705002597	active site
467705002598	motif I; other site
467705002599	motif II; other site
467705002600	excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558
467705002601	Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434
467705002602	GIY-YIG motif/motif A; other site
467705002603	active site
467705002604	catalytic site [active]
467705002605	putative DNA binding site [nucleotide binding]; other site
467705002606	metal binding site [ion binding]; metal-binding site
467705002607	UvrB/uvrC motif; Region: UVR; pfam02151
467705002608	UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459
467705002609	Calcineurin-like phosphoesterase superfamily domain; Region: Metallophos_2; pfam12850
467705002610	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
467705002611	active site
467705002612	metal binding site [ion binding]; metal-binding site
467705002613	Nitroreductase-like family 1. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_1; cd02137
467705002614	dimer interface [polypeptide binding]; other site
467705002615	FMN binding site [chemical binding]; other site
467705002616	dipeptidase PepV; Reviewed; Region: PRK07318
467705002617	M20 Peptidase Xaa-His dipeptidase (PepV) degrades hydrophobic dipeptides; Region: M20_PepV; cd03888
467705002618	active site
467705002619	metal binding site [ion binding]; metal-binding site
467705002620	Uncharacterized subfamily of Uracil-DNA glycosylases; Region: UDG_like_1; cd10033
467705002621	putative uracil binding site [chemical binding]; other site
467705002622	putative active site [active]
467705002623	This CD includes bacterial (Agrobacterium tumefaciens and Caulobacter crescentus ProX, and Clostridium sticklandii PrdX) and eukaryotic (Plasmodium falciparum N-terminal ProRS editing domain) sequences. The C. sticklandii PrdX protein, a homolog of the...; Region: PrdX_deacylase; cd04335
467705002624	putative deacylase active site [active]
467705002625	TfoX N-terminal domain; Region: TfoX_N; pfam04993
467705002626	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
467705002627	Quinone oxidoreductase (QOR); Region: quinone_oxidoreductase_like_1; cd08243
467705002628	NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604
467705002629	putative NAD(P) binding site [chemical binding]; other site
467705002630	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158
467705002631	active site residue [active]
467705002632	D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: VanY; COG1876
467705002633	D-alanyl-D-alanine carboxypeptidase; Region: VanY; pfam02557
467705002634	Cupin domain; Region: Cupin_2; cl17218
467705002635	FOG: Glucan-binding domain (YG repeat) [General function prediction only]; Region: COG5263
467705002636	SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379
467705002637	SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379
467705002638	50S ribosomal protein L31 type B; Reviewed; Region: rpmE2; PRK01678
467705002639	Exopolyphosphatase-related proteins [General function prediction only]; Region: COG0618
467705002640	DHH family; Region: DHH; pfam01368
467705002641	flavodoxin; Validated; Region: PRK07308
467705002642	Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628
467705002643	Domain of unknown function DUF20; Region: UPF0118; pfam01594
467705002644	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
467705002645	binding surface
467705002646	TPR motif; other site
467705002647	Alpha-acetolactate decarboxylase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: AlsD; COG3527
467705002648	Gram-positive signal peptide, YSIRK family; Region: YSIRK_signal; TIGR01168
467705002649	CshA-type fibril repeat; Region: CshA_fibril_rpt; TIGR04225
467705002650	CshA-type fibril repeat; Region: CshA_fibril_rpt; TIGR04225
467705002651	CshA-type fibril repeat; Region: CshA_fibril_rpt; TIGR04225
467705002652	CshA-type fibril repeat; Region: CshA_fibril_rpt; TIGR04225
467705002653	CshA-type fibril repeat; Region: CshA_fibril_rpt; TIGR04225
467705002654	CshA-type fibril repeat; Region: CshA_fibril_rpt; TIGR04225
467705002655	CshA-type fibril repeat; Region: CshA_fibril_rpt; TIGR04225
467705002656	CshA-type fibril repeat; Region: CshA_fibril_rpt; TIGR04225
467705002657	CshA-type fibril repeat; Region: CshA_fibril_rpt; TIGR04225
467705002658	CshA-type fibril repeat; Region: CshA_fibril_rpt; TIGR04225
467705002659	CshA-type fibril repeat; Region: CshA_fibril_rpt; TIGR04225
467705002660	CshA-type fibril repeat; Region: CshA_fibril_rpt; TIGR04225
467705002661	CshA-type fibril repeat; Region: CshA_fibril_rpt; TIGR04225
467705002662	CshA-type fibril repeat; Region: CshA_fibril_rpt; TIGR04225
467705002663	CshA-type fibril repeat; Region: CshA_fibril_rpt; TIGR04225
467705002664	CshA-type fibril repeat; Region: CshA_fibril_rpt; TIGR04225
467705002665	CshA-type fibril repeat; Region: CshA_fibril_rpt; TIGR04225
467705002666	Predicted RNA-binding protein homologous to eukaryotic snRNP [Transcription]; Region: COG1293
467705002667	Domain of unknown function (DUF814); Region: DUF814; pfam05670
467705002668	Type I periplasmic ligand-binding domain of uncharacterized ABC-type transport systems that are predicted to be involved in the uptake of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_uncharacterized_transporter; cd06325
467705002669	Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407
467705002670	zinc binding site [ion binding]; other site
467705002671	putative ligand binding site [chemical binding]; other site
467705002672	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
467705002673	Transmembrane subunit (TM) of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which are involved in the uptake of branched-chain amino acids (AAs), as well as TMs of transporters involved in the uptake of...; Region: TM_PBP1_branched-chain-AA_like; cd06574
467705002674	TM-ABC transporter signature motif; other site
467705002675	ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: PhnK; COG1101
467705002676	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
467705002677	Walker A/P-loop; other site
467705002678	ATP binding site [chemical binding]; other site
467705002679	Q-loop/lid; other site
467705002680	ABC transporter signature motif; other site
467705002681	Walker B; other site
467705002682	D-loop; other site
467705002683	H-loop/switch region; other site
467705002684	phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488
467705002685	Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912
467705002686	Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496
467705002687	dimer interface [polypeptide binding]; other site
467705002688	motif 1; other site
467705002689	active site
467705002690	motif 2; other site
467705002691	motif 3; other site
467705002692	Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673
467705002693	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
467705002694	Coenzyme A binding pocket [chemical binding]; other site
467705002695	phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629
467705002696	tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain.  PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796
467705002697	putative tRNA-binding site [nucleotide binding]; other site
467705002698	B3/4 domain; Region: B3_4; pfam03483
467705002699	tRNA synthetase B5 domain; Region: B5; smart00874
467705002700	Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA,  PheRS is an...; Region: PheRS_beta_core; cd00769
467705002701	dimer interface [polypeptide binding]; other site
467705002702	motif 1; other site
467705002703	motif 3; other site
467705002704	motif 2; other site
467705002705	Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; smart00896
467705002706	Protein of unknown function (DUF1722); Region: DUF1722; pfam08349
467705002707	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
467705002708	non-specific DNA binding site [nucleotide binding]; other site
467705002709	salt bridge; other site
467705002710	sequence-specific DNA binding site [nucleotide binding]; other site
467705002711	Protein of unknown function (DUF2089); Region: DUF2089; pfam09862
467705002712	Bacterial lipoprotein; Region: DUF3642; pfam12182
467705002713	Transcriptional antiterminator [Transcription]; Region: COG3933
467705002714	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
467705002715	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
467705002716	Transcriptional regulator C-terminal region; Region: TetR_C_8; pfam14278
467705002717	ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577
467705002718	FtsX-like permease family; Region: FtsX; pfam02687
467705002719	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
467705002720	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
467705002721	Walker A/P-loop; other site
467705002722	ATP binding site [chemical binding]; other site
467705002723	Q-loop/lid; other site
467705002724	ABC transporter signature motif; other site
467705002725	Walker B; other site
467705002726	D-loop; other site
467705002727	H-loop/switch region; other site
467705002728	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
467705002729	non-specific DNA binding site [nucleotide binding]; other site
467705002730	salt bridge; other site
467705002731	sequence-specific DNA binding site [nucleotide binding]; other site
467705002732	transcriptional activator, Rgg/GadR/MutR family, C-terminal domain; Region: RGG_Cterm; TIGR01716
467705002733	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
467705002734	Type 1 glutamine amidotransferase (GATase1) domain found in Cobyric Acid Synthase (CobQ); Region: GATase1_CobQ; cd01750
467705002735	catalytic triad [active]
467705002736	UDP-N-acetylmuramyl tripeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurE; COG0769
467705002737	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
467705002738	Domain of unknown function (DUF1727); Region: DUF1727; pfam08353
467705002739	Uncharacterized conserved protein [Function unknown]; Region: COG1624
467705002740	DisA bacterial checkpoint controller nucleotide-binding; Region: DisA_N; pfam02457
467705002741	YbbR-like protein; Region: YbbR; pfam07949
467705002742	YbbR-like protein; Region: YbbR; pfam07949
467705002743	phosphoglucosamine mutase; Provisional; Region: glmM; PRK14316
467705002744	GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802
467705002745	active site
467705002746	substrate binding site [chemical binding]; other site
467705002747	metal binding site [ion binding]; metal-binding site
467705002748	Collagen binding domain; Region: Collagen_bind; pfam05737
467705002749	streptococcal pilin isopeptide linkage domain; Region: strep_pil_rpt; TIGR03786
467705002750	Repeat unit of collagen-binding protein domain B; Region: CollagenBindB; cd00222
467705002751	domain interaction interfaces [polypeptide binding]; other site
467705002752	GTPase CgtA; Reviewed; Region: obgE; PRK12297
467705002753	GTP1/OBG; Region: GTP1_OBG; pfam01018
467705002754	Obg GTPase; Region: Obg; cd01898
467705002755	G1 box; other site
467705002756	GTP/Mg2+ binding site [chemical binding]; other site
467705002757	Switch I region; other site
467705002758	G2 box; other site
467705002759	G3 box; other site
467705002760	Switch II region; other site
467705002761	G4 box; other site
467705002762	G5 box; other site
467705002763	Domain of unknown function (DUF1967); Region: DUF1967; pfam09269
467705002764	Uncharacterized protein family (UPF0157); Region: UPF0157; pfam04229
467705002765	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
467705002766	Methyltransferase domain; Region: Methyltransf_31; pfam13847
467705002767	S-adenosylmethionine binding site [chemical binding]; other site
467705002768	Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020
467705002769	conserved cys residue [active]
467705002770	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
467705002771	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
467705002772	non-specific DNA binding site [nucleotide binding]; other site
467705002773	salt bridge; other site
467705002774	sequence-specific DNA binding site [nucleotide binding]; other site
467705002775	Antidote-toxin recognition MazE; Region: Antitoxin-MazE; cl00877
467705002776	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
467705002777	GAF domain-containing protein [Signal transduction mechanisms]; Region: COG1956
467705002778	GAF domain; Region: GAF_2; pfam13185
467705002779	DNA polymerase III subunits gamma and tau; Validated; Region: PRK05563
467705002780	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
467705002781	Walker A motif; other site
467705002782	ATP binding site [chemical binding]; other site
467705002783	Walker B motif; other site
467705002784	arginine finger; other site
467705002785	DNA polymerase III subunits gamma and tau domain III; Region: DNA_pol3_gamma3; pfam12169
467705002786	Protein of unknown function (DUF3272); Region: DUF3272; pfam11676
467705002787	Biotin operon repressor [Transcription]; Region: BirA; COG1654
467705002788	bifunctional biotin--[acetyl-CoA-carboxylase] synthetase/biotin operon repressor; Provisional; Region: PRK11886
467705002789	Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; pfam03099
467705002790	Biotin protein ligase C terminal domain; Region: BPL_C; pfam02237
467705002791	DNA-binding transcriptional repressor EbgR; Provisional; Region: PRK10339
467705002792	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
467705002793	DNA binding site [nucleotide binding]
467705002794	Ligand-binding domain of DNA transcription repressor GalR which is one of two regulatory proteins involved in galactose transport and metabolism; Region: PBP1_GalR; cd01544
467705002795	putative dimerization interface [polypeptide binding]; other site
467705002796	putative ligand binding site [chemical binding]; other site
467705002797	2-isopropylmalate synthase; Validated; Region: PRK00915
467705002798	2-isopropylmalate synthase (IPMS), N-terminal catalytic TIM barrel domain; Region: DRE_TIM_IPMS; cd07940
467705002799	active site
467705002800	catalytic residues [active]
467705002801	metal binding site [ion binding]; metal-binding site
467705002802	LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; pfam08502
467705002803	3-isopropylmalate dehydrogenase; Provisional; Region: PRK00772
467705002804	tartrate dehydrogenase; Region: TTC; TIGR02089
467705002805	Predicted membrane protein [Function unknown]; Region: COG3326
467705002806	3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402
467705002807	3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583
467705002808	substrate binding site [chemical binding]; other site
467705002809	ligand binding site [chemical binding]; other site
467705002810	isopropylmalate isomerase small subunit; Provisional; Region: leuD; PRK01641
467705002811	Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577
467705002812	substrate binding site [chemical binding]; other site
467705002813	Telomere recombination; Region: Sua5_yciO_yrdC; cl00305
467705002814	Winged helix DNA-binding domain; Region: HTH_27; pfam13463
467705002815	ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126
467705002816	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
467705002817	Walker A/P-loop; other site
467705002818	ATP binding site [chemical binding]; other site
467705002819	Q-loop/lid; other site
467705002820	ABC transporter signature motif; other site
467705002821	Walker B; other site
467705002822	D-loop; other site
467705002823	H-loop/switch region; other site
467705002824	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
467705002825	dimer interface [polypeptide binding]; other site
467705002826	conserved gate region; other site
467705002827	putative PBP binding loops; other site
467705002828	ABC-ATPase subunit interface; other site
467705002829	Periplasmic glycine betaine/choline-binding (lipo)protein of an ABC-type transport system (osmoprotectant binding protein) [Cell envelope biogenesis, outer membrane]; Region: OpuBC; COG1732
467705002830	ABC-type proline/glycine betaine transport systems, periplasmic components [Amino acid transport and metabolism]; Region: ProX; cl17891
467705002831	Cobalt transport protein; Region: CbiQ; cl00463
467705002832	ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122
467705002833	First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225
467705002834	Walker A/P-loop; other site
467705002835	ATP binding site [chemical binding]; other site
467705002836	Q-loop/lid; other site
467705002837	ABC transporter signature motif; other site
467705002838	Walker B; other site
467705002839	D-loop; other site
467705002840	H-loop/switch region; other site
467705002841	ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122
467705002842	First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225
467705002843	Walker A/P-loop; other site
467705002844	ATP binding site [chemical binding]; other site
467705002845	Q-loop/lid; other site
467705002846	ABC transporter signature motif; other site
467705002847	Walker B; other site
467705002848	D-loop; other site
467705002849	H-loop/switch region; other site
467705002850	Lactococcus lactis RepB C-terminus; Region: L_lactis_RepB_C; pfam06430
467705002851	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
467705002852	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
467705002853	Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]; Region: CzcD; COG1230
467705002854	galactokinase; Provisional; Region: PRK05322
467705002855	Galactokinase galactose-binding signature; Region: GalKase_gal_bdg; pfam10509
467705002856	GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288
467705002857	GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544
467705002858	galactose-1-phosphate uridylyltransferase; Provisional; Region: PRK05270
467705002859	Galactose-1-phosphate uridyl transferase, N-terminal domain; Region: GalP_UDP_transf; pfam01087
467705002860	Galactose-1-phosphate uridyl transferase, C-terminal domain; Region: GalP_UDP_tr_C; pfam02744
467705002861	UDP-glucose 4-epimerase [Cell envelope biogenesis, outer membrane]; Region: GalE; COG1087
467705002862	UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247
467705002863	NAD binding site [chemical binding]; other site
467705002864	homodimer interface [polypeptide binding]; other site
467705002865	active site
467705002866	substrate binding site [chemical binding]; other site
467705002867	Putative integral membrane protein DUF46; Region: DUF46; cl17511
467705002868	Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326
467705002869	PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391
467705002870	Phosphatidylserine synthase [Lipid metabolism]; Region: PssA; COG1183
467705002871	CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; pfam01066
467705002872	Phosphatidylserine decarboxylase; Region: PS_Dcarbxylase; cl03656
467705002873	prenyltransferase; Provisional; Region: ubiA; PRK13592
467705002874	UbiA prenyltransferase family; Region: UbiA; pfam01040
467705002875	phosphoenolpyruvate synthase; Validated; Region: PRK06241
467705002876	Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326
467705002877	PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391
467705002878	Gram-positive signal peptide, YSIRK family; Region: YSIRK_signal; TIGR01168
467705002879	G5 domain; Region: G5; pfam07501
467705002880	zinc metalloproteinase 18-residue repeat; Region: zmp_18_rpt; TIGR04227
467705002881	zinc metalloproteinase 18-residue repeat; Region: zmp_18_rpt; TIGR04227
467705002882	zinc metalloproteinase 18-residue repeat; Region: zmp_18_rpt; TIGR04227
467705002883	zinc metalloproteinase 18-residue repeat; Region: zmp_18_rpt; TIGR04227
467705002884	zinc metalloproteinase 18-residue repeat; Region: zmp_18_rpt; TIGR04227
467705002885	zinc metalloproteinase 18-residue repeat; Region: zmp_18_rpt; TIGR04227
467705002886	zinc metalloproteinase 18-residue repeat; Region: zmp_18_rpt; TIGR04227
467705002887	zinc metalloproteinase 18-residue repeat; Region: zmp_18_rpt; TIGR04227
467705002888	zinc metalloproteinase 18-residue repeat; Region: zmp_18_rpt; TIGR04227
467705002889	zinc metalloproteinase 18-residue repeat; Region: zmp_18_rpt; TIGR04227
467705002890	zinc metalloproteinase 18-residue repeat; Region: zmp_18_rpt; TIGR04227
467705002891	zinc metalloproteinase 18-residue repeat; Region: zmp_18_rpt; TIGR04227
467705002892	G5 domain; Region: G5; pfam07501
467705002893	G5 domain; Region: G5; pfam07501
467705002894	G5 domain; Region: G5; pfam07501
467705002895	G5 domain; Region: G5; pfam07501
467705002896	G5 domain; Region: G5; pfam07501
467705002897	M26 IgA1-specific Metallo-endopeptidase N-terminal region; Region: Peptidase_M26_N; pfam05342
467705002898	M26 IgA1-specific Metallo-endopeptidase C-terminal region; Region: Peptidase_M26_C; pfam07580
467705002899	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
467705002900	WHG domain; Region: WHG; pfam13305
467705002901	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
467705002902	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
467705002903	Walker A/P-loop; other site
467705002904	ATP binding site [chemical binding]; other site
467705002905	Q-loop/lid; other site
467705002906	ABC transporter signature motif; other site
467705002907	Walker B; other site
467705002908	D-loop; other site
467705002909	H-loop/switch region; other site
467705002910	FtsX-like permease family; Region: FtsX; pfam02687
467705002911	Cellulase M and related proteins [Carbohydrate transport and metabolism]; Region: FrvX; COG1363
467705002912	M42 Peptidase, Endoglucanase-like subfamily; Region: M42_glucanase_like; cd05657
467705002913	putative oligomer interface [polypeptide binding]; other site
467705002914	putative active site [active]
467705002915	metal binding site [ion binding]; metal-binding site
467705002916	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
467705002917	Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726
467705002918	Catalytic NodB homology domain of the carbohydrate esterase 4 superfamily; Region: CE4_SF; cl15692
467705002919	DEAD-like helicases superfamily; Region: DEXDc; smart00487
467705002920	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251
467705002921	ATP binding site [chemical binding]; other site
467705002922	putative Mg++ binding site [ion binding]; other site
467705002923	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
467705002924	nucleotide binding region [chemical binding]; other site
467705002925	ATP-binding site [chemical binding]; other site
467705002926	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
467705002927	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
467705002928	Uridine kinase [Nucleotide transport and metabolism]; Region: Udk; COG0572
467705002929	Uridine monophosphate kinase (UMPK, EC 2.7.1.48), also known as uridine kinase or uridine-cytidine kinase (UCK), catalyzes the reversible phosphoryl transfer from ATP to uridine or cytidine to yield UMP or CMP. In the primidine nucleotide-salvage pathway; Region: UMPK; cd02023
467705002930	Sugar specificity; other site
467705002931	Pyrimidine base specificity; other site
467705002932	ATP-binding site [chemical binding]; other site
467705002933	Protein of unknown function (DUF1275); Region: DUF1275; pfam06912
467705002934	YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448
467705002935	homotrimer interaction site [polypeptide binding]; other site
467705002936	putative active site [active]
467705002937	glmZ(sRNA)-inactivating NTPase; Provisional; Region: PRK05416
467705002938	conserved hypothetical protein, cofD-related; Region: CofD_related; TIGR01826
467705002939	Family of CofD-like proteins and proteins related to YvcK; Region: CofD_YvcK; cd07044
467705002940	phosphate binding site [ion binding]; other site
467705002941	dimer interface [polypeptide binding]; other site
467705002942	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1481
467705002943	Sporulation Regulator WhiA N terminal; Region: WhiA_N; pfam10298
467705002944	Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583
467705002945	ParB-like nuclease domain; Region: ParB; smart00470
467705002946	Uncharacterized protein involved in copper resistance [Inorganic ion transport and metabolism]; Region: CutC; COG3142
467705002947	Protein of unknown function (DUF419); Region: DUF419; cl15265
467705002948	putative multidrug transporter membrane\ATP-binding components; Provisional; Region: PRK10789
467705002949	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
467705002950	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
467705002951	Walker A/P-loop; other site
467705002952	ATP binding site [chemical binding]; other site
467705002953	Q-loop/lid; other site
467705002954	ABC transporter signature motif; other site
467705002955	Walker B; other site
467705002956	D-loop; other site
467705002957	H-loop/switch region; other site
467705002958	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
467705002959	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
467705002960	ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254
467705002961	Walker A/P-loop; other site
467705002962	ATP binding site [chemical binding]; other site
467705002963	Q-loop/lid; other site
467705002964	ABC transporter signature motif; other site
467705002965	Walker B; other site
467705002966	D-loop; other site
467705002967	H-loop/switch region; other site
467705002968	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167
467705002969	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
467705002970	DNA-binding site [nucleotide binding]; DNA binding site
467705002971	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
467705002972	pyridoxal 5'-phosphate binding site [chemical binding]; other site
467705002973	homodimer interface [polypeptide binding]; other site
467705002974	catalytic residue [active]
467705002975	pyridoxamine kinase; Validated; Region: PRK07105
467705002976	substrate binding site [chemical binding]; other site
467705002977	ATP binding site [chemical binding]; other site
467705002978	Predicted membrane protein [Function unknown]; Region: COG4720
467705002979	KxYKxGKxW signal peptide; Region: KxYKxGKxW; TIGR03715
467705002980	serine-rich repeat adhesion glycoprotein AST domain; Region: ser_adhes_Nterm; TIGR04224
467705002981	glycosyltransferase, SP_1767 family; Region: glyco_access_1; TIGR03728
467705002982	beta-1,6-galactofuranosyltransferase; Provisional; Region: PRK09814
467705002983	Glycosyl transferase 4-like domain; Region: Glyco_trans_4_4; cl17183
467705002984	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
467705002985	preprotein translocase subunit SecY; Reviewed; Region: secY; PRK12417
467705002986	SecY translocase; Region: SecY; pfam00344
467705002987	accessory Sec system protein Asp1; Region: acc_sec_asp1; TIGR03713
467705002988	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
467705002989	accessory Sec system protein Asp2; Region: acc_sec_asp2; TIGR03712
467705002990	accessory Sec system protein Asp3; Region: acc_sec_asp3; TIGR03711
467705002991	accessory Sec system glycosylation protein GtfA; Region: TIGR02918
467705002992	This family is most closely related to the GT1 family of glycosyltransferases and is named after gtfA in Streptococcus gordonii, where it plays a role in the O-linked glycosylation of GspB, a cell surface glycoprotein involved in platelet binding.  In...; Region: GT1_gtfA_like; cd04949
467705002993	accessory Sec system glycosyltransferase GtfB; Region: TIGR02919
467705002994	Uncharacterized protein conserved in bacteria [Function unknown]; Region: DegV; COG1307
467705002995	Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645
467705002996	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
467705002997	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
467705002998	Deoxycytidylate deaminase domain. Deoxycytidylate deaminase catalyzes the deamination of dCMP to dUMP, providing the nucleotide substrate for thymidylate synthase. The enzyme binds Zn++, which is required for catalytic activity. The activity of the...; Region: deoxycytidylate_deaminase; cd01286
467705002999	catalytic motif [active]
467705003000	Zn binding site [ion binding]; other site
467705003001	Bacterial periplasmic substrate-binding proteins; Region: PBPb; smart00062
467705003002	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
467705003003	substrate binding pocket [chemical binding]; other site
467705003004	membrane-bound complex binding site; other site
467705003005	hinge residues; other site
467705003006	ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126
467705003007	ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262
467705003008	Walker A/P-loop; other site
467705003009	ATP binding site [chemical binding]; other site
467705003010	Q-loop/lid; other site
467705003011	ABC transporter signature motif; other site
467705003012	Walker B; other site
467705003013	D-loop; other site
467705003014	H-loop/switch region; other site
467705003015	ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215
467705003016	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
467705003017	dimer interface [polypeptide binding]; other site
467705003018	conserved gate region; other site
467705003019	putative PBP binding loops; other site
467705003020	ABC-ATPase subunit interface; other site
467705003021	ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215
467705003022	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
467705003023	dimer interface [polypeptide binding]; other site
467705003024	conserved gate region; other site
467705003025	putative PBP binding loops; other site
467705003026	ABC-ATPase subunit interface; other site
467705003027	S-adenosylmethionine synthetase; Validated; Region: PRK05250
467705003028	S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438
467705003029	S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772
467705003030	S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773
467705003031	Predicted transcriptional regulator [Transcription]; Region: COG2378
467705003032	HTH domain; Region: HTH_11; pfam08279
467705003033	WYL domain; Region: WYL; pfam13280
467705003034	Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109
467705003035	benzoate transport; Region: 2A0115; TIGR00895
467705003036	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
467705003037	putative substrate translocation pore; other site
467705003038	Protein of unknown function (DUF3042); Region: DUF3042; pfam11240
467705003039	tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324
467705003040	tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091
467705003041	GTP-binding protein HflX; Region: GTP_HflX; TIGR03156
467705003042	GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167
467705003043	HflX GTPase family; Region: HflX; cd01878
467705003044	G1 box; other site
467705003045	GTP/Mg2+ binding site [chemical binding]; other site
467705003046	Switch I region; other site
467705003047	G2 box; other site
467705003048	G3 box; other site
467705003049	Switch II region; other site
467705003050	G4 box; other site
467705003051	G5 box; other site
467705003052	Galactose-1-phosphate uridyl transferase, N-terminal domain; Region: GalP_UDP_transf; pfam01087
467705003053	ribonuclease Z; Region: RNase_Z; TIGR02651
467705003054	Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300
467705003055	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
467705003056	NAD(P) binding site [chemical binding]; other site
467705003057	active site
467705003058	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
467705003059	S-adenosylmethionine binding site [chemical binding]; other site
467705003060	HD domain; Region: HD_3; pfam13023
467705003061	single-stranded-DNA-specific exonuclease RecJ; Region: recJ; TIGR00644
467705003062	DHH family; Region: DHH; pfam01368
467705003063	DHHA1 domain; Region: DHHA1; pfam02272
467705003064	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4199
467705003065	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
467705003066	active site
467705003067	Homoserine O-succinyltransferase; Region: HTS; pfam04204
467705003068	Type 1 glutamine amidotransferase (GATase1)-like domain found in homoserine trans-succinylase (HTS); Region: GATase1_HTS; cd03131
467705003069	proposed active site lysine [active]
467705003070	conserved cys residue [active]
467705003071	Putative primosome component and related proteins [DNA replication, recombination, and repair]; Region: DnaD; COG3935
467705003072	DnaD and phage-associated domain; Region: DnaD_dom; TIGR01446
467705003073	putative S-transferase; Provisional; Region: PRK11752
467705003074	GST_N family, Ure2p-like subfamily; composed of the Saccharomyces cerevisiae Ure2p and related GSTs. Ure2p is a regulator for nitrogen catabolism in yeast. It represses the expression of several gene products involved in the use of poor nitrogen sources...; Region: GST_N_Ure2p_like; cd03048
467705003075	C-terminal domain interface [polypeptide binding]; other site
467705003076	GSH binding site (G-site) [chemical binding]; other site
467705003077	dimer interface [polypeptide binding]; other site
467705003078	C-terminal, alpha helical domain of Escherichia coli Yghu Glutathione S-transferases and related uncharacterized proteins; Region: GST_C_YghU_like; cd10292
467705003079	dimer interface [polypeptide binding]; other site
467705003080	N-terminal domain interface [polypeptide binding]; other site
467705003081	active site
467705003082	Predicted SAM-dependent methyltransferase [General function prediction only]; Region: COG2384
467705003083	Family of unknown function (DUF633); Region: DUF633; pfam04816
467705003084	Uncharacterized conserved protein [Function unknown]; Region: COG0327
467705003085	NIF3 (NGG1p interacting factor 3); Region: NIF3; pfam01784
467705003086	Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665
467705003087	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
467705003088	MutT homolog-1 (MTH1) is a member of the Nudix hydrolase superfamily. MTH1, the mammalian counterpart of MutT, hydrolyzes oxidized purine nucleoside triphosphates, such as 8-oxo-dGTP and 2-hydroxy-ATP, to monophosphates, thereby preventing the...; Region: MTH1; cd03427
467705003089	putative active site [active]
467705003090	nucleotide binding site [chemical binding]; other site
467705003091	nudix motif; other site
467705003092	putative metal binding site [ion binding]; other site
467705003093	G1P_TT_short is the short form of glucose-1-phosphate thymidylyltransferase; Region: G1P_TT_short; cd02538
467705003094	glucose-1-phosphate thymidylyltransferase, short form; Region: rmlA; TIGR01207
467705003095	substrate binding site; other site
467705003096	tetramer interface; other site
467705003097	dTDP-4-dehydrorhamnose 3,5-epimerase and related enzymes [Cell envelope biogenesis, outer membrane]; Region: RfbC; COG1898
467705003098	dTDP-D-glucose 4,6-dehydratase [Cell envelope biogenesis, outer membrane]; Region: RfbB; COG1088
467705003099	dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246
467705003100	NAD binding site [chemical binding]; other site
467705003101	substrate binding site [chemical binding]; other site
467705003102	homodimer interface [polypeptide binding]; other site
467705003103	active site
467705003104	UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247
467705003105	UDP-glucose 4-epimerase; Region: PLN02240
467705003106	NAD binding site [chemical binding]; other site
467705003107	homodimer interface [polypeptide binding]; other site
467705003108	active site
467705003109	substrate binding site [chemical binding]; other site
467705003110	dolichyl-phosphate beta-D-mannosyltransferase; Region: PLN02726
467705003111	DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179
467705003112	Ligand binding site; other site
467705003113	Putative Catalytic site; other site
467705003114	DXD motif; other site
467705003115	Uncharacterized conserved protein (DUF2304); Region: DUF2304; pfam10066
467705003116	Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326
467705003117	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
467705003118	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761
467705003119	active site
467705003120	Predicted membrane protein (DUF2142); Region: DUF2142; pfam09913
467705003121	undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714
467705003122	Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187
467705003123	Ligand binding site; other site
467705003124	Putative Catalytic site; other site
467705003125	DXD motif; other site
467705003126	dTDP-6-deoxy-L-lyxo-4-hexulose reductase and related proteins, extended (e) SDRs; Region: dTDP_HR_like_SDR_e; cd05254
467705003127	RmlD substrate binding domain; Region: RmlD_sub_bind; pfam04321
467705003128	NADP binding site [chemical binding]; other site
467705003129	active site
467705003130	putative substrate binding site [chemical binding]; other site
467705003131	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
467705003132	This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_6; cd04955
467705003133	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
467705003134	Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_d; cd04196
467705003135	Probable Catalytic site; other site
467705003136	ABC-type polysaccharide/polyol phosphate export systems, permease component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagG; COG1682
467705003137	ABC-2 type transporter; Region: ABC2_membrane; pfam01061
467705003138	ABC-type polysaccharide/polyol phosphate transport system, ATPase component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagH; COG1134
467705003139	ATP-binding cassette component of polysaccharide transport system; Region: ABC_KpsT_Wzt; cd03220
467705003140	Walker A/P-loop; other site
467705003141	ATP binding site [chemical binding]; other site
467705003142	Q-loop/lid; other site
467705003143	ABC transporter signature motif; other site
467705003144	Walker B; other site
467705003145	D-loop; other site
467705003146	H-loop/switch region; other site
467705003147	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
467705003148	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761
467705003149	active site
467705003150	Rhamnan synthesis protein F; Region: RgpF; pfam05045
467705003151	Sulfatase; Region: Sulfatase; pfam00884
467705003152	Ferredoxin [Energy production and conversion]; Region: Fer; COG1141
467705003153	cytidylate kinase; Provisional; Region: cmk; PRK00023
467705003154	Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020
467705003155	CMP-binding site; other site
467705003156	The sites determining sugar specificity; other site
467705003157	translation initiation factor IF-3; Reviewed; Region: infC; PRK00028
467705003158	Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198
467705003159	Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707
467705003160	50S ribosomal protein L35; Reviewed; Region: rpmI; PRK00172
467705003161	Ribosomal protein L20; Region: Ribosomal_L20; cd07026
467705003162	23S rRNA binding site [nucleotide binding]; other site
467705003163	L21 binding site [polypeptide binding]; other site
467705003164	L13 binding site [polypeptide binding]; other site
467705003165	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
467705003166	Glyoxalase I catalyzes the isomerization of the hemithioacetal, formed by a 2-oxoaldehyde and glutathione, to S-D-lactoylglutathione; Region: Glyoxalase_I; cd07233
467705003167	dimer interface [polypeptide binding]; other site
467705003168	active site
467705003169	metal binding site [ion binding]; metal-binding site
467705003170	glutathione binding site [chemical binding]; other site
467705003171	ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126
467705003172	ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262
467705003173	Walker A/P-loop; other site
467705003174	ATP binding site [chemical binding]; other site
467705003175	Q-loop/lid; other site
467705003176	ABC transporter signature motif; other site
467705003177	Walker B; other site
467705003178	D-loop; other site
467705003179	H-loop/switch region; other site
467705003180	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
467705003181	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
467705003182	substrate binding pocket [chemical binding]; other site
467705003183	membrane-bound complex binding site; other site
467705003184	hinge residues; other site
467705003185	ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215
467705003186	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
467705003187	dimer interface [polypeptide binding]; other site
467705003188	conserved gate region; other site
467705003189	putative PBP binding loops; other site
467705003190	ABC-ATPase subunit interface; other site
467705003191	excinuclease ABC subunit B; Provisional; Region: PRK05298
467705003192	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
467705003193	ATP binding site [chemical binding]; other site
467705003194	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
467705003195	nucleotide binding region [chemical binding]; other site
467705003196	ATP-binding site [chemical binding]; other site
467705003197	Ultra-violet resistance protein B; Region: UvrB; pfam12344
467705003198	UvrB/uvrC motif; Region: UVR; pfam02151
467705003199	Acetyltransferases [General function prediction only]; Region: RimI; COG0456
467705003200	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
467705003201	Coenzyme A binding pocket [chemical binding]; other site
467705003202	Protein of unknown function (DUF1697); Region: DUF1697; pfam08002
467705003203	Tunnelling fold (T-fold). The five known T-folds are found in five different enzymes with different functions: dihydroneopterin-triphosphate epimerase (DHNTPE), dihydroneopterin aldolase (DHNA) , GTP cyclohydrolase I (GTPCH-1),  6-pyrovoyl...; Region: TFold; cl00263
467705003204	MutT homolog-1 (MTH1) is a member of the Nudix hydrolase superfamily. MTH1, the mammalian counterpart of MutT, hydrolyzes oxidized purine nucleoside triphosphates, such as 8-oxo-dGTP and 2-hydroxy-ATP, to monophosphates, thereby preventing the...; Region: MTH1; cd03427
467705003205	putative active site [active]
467705003206	nucleotide binding site [chemical binding]; other site
467705003207	nudix motif; other site
467705003208	putative metal binding site [ion binding]; other site
467705003209	Predicted small molecule binding protein (contains 3H domain) [General function prediction only]; Region: COG1827
467705003210	HTH domain; Region: HTH_11; pfam08279
467705003211	3H domain; Region: 3H; pfam02829
467705003212	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4487
467705003213	Uncharacterized protein conserved in bacteria (DUF2130); Region: DUF2130; pfam09903
467705003214	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
467705003215	homoserine O-acetyltransferase; Provisional; Region: metX; cl17114
467705003216	tRNA pseudouridine synthase B; Provisional; Region: truB; PRK02484
467705003217	Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573
467705003218	RNA binding site [nucleotide binding]; other site
467705003219	active site
467705003220	bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627
467705003221	FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064
467705003222	active site
467705003223	Riboflavin kinase; Region: Flavokinase; smart00904
467705003224	Arsenate Reductase (ArsC) family, Spx subfamily; Spx is a unique RNA polymerase (RNAP)-binding protein present in bacilli and some mollicutes. It inhibits transcription by binding to the C-terminal domain of the alpha subunit of RNAP, disrupting complex...; Region: ArsC_Spx; cd03032
467705003225	ArsC family; Region: ArsC; pfam03960
467705003226	putative catalytic residues [active]
467705003227	thiol/disulfide switch; other site
467705003228	hypothetical protein; Provisional; Region: PRK04387
467705003229	Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483
467705003230	Inositol-monophosphatase-like domains. This family of phosphatases is dependent on bivalent metal ions such as Mg++, and many members are inhibited by Li+ (which is thought to displace a bivalent ion in the active site). Substrates include fructose-1; Region: IMPase_like; cd01637
467705003231	active site
467705003232	tRNA and rRNA cytosine-C5-methylases [Translation, ribosomal structure and biogenesis]; Region: Sun; COG0144
467705003233	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
467705003234	S-adenosylmethionine binding site [chemical binding]; other site
467705003235	Uncharacterized conserved protein [Function unknown]; Region: COG3270
467705003236	pre-rRNA processing and ribosome biogenesis; Region: Nol1_Nop2_Fmu_2; pfam13636
467705003237	phosphate binding protein; Region: ptsS_2; TIGR02136
467705003238	Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531
467705003239	sulfate transport protein; Provisional; Region: cysT; CHL00187
467705003240	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
467705003241	dimer interface [polypeptide binding]; other site
467705003242	conserved gate region; other site
467705003243	putative PBP binding loops; other site
467705003244	ABC-ATPase subunit interface; other site
467705003245	ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstA; COG0581
467705003246	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
467705003247	dimer interface [polypeptide binding]; other site
467705003248	conserved gate region; other site
467705003249	putative PBP binding loops; other site
467705003250	ABC-ATPase subunit interface; other site
467705003251	phosphate transporter ATP-binding protein; Provisional; Region: PRK14237
467705003252	ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260
467705003253	Walker A/P-loop; other site
467705003254	ATP binding site [chemical binding]; other site
467705003255	Q-loop/lid; other site
467705003256	ABC transporter signature motif; other site
467705003257	Walker B; other site
467705003258	D-loop; other site
467705003259	H-loop/switch region; other site
467705003260	phosphate transporter ATP-binding protein; Provisional; Region: PRK14239
467705003261	ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260
467705003262	Walker A/P-loop; other site
467705003263	ATP binding site [chemical binding]; other site
467705003264	Q-loop/lid; other site
467705003265	ABC transporter signature motif; other site
467705003266	Walker B; other site
467705003267	D-loop; other site
467705003268	H-loop/switch region; other site
467705003269	phosphate transport system regulatory protein PhoU; Region: phoU_full; TIGR02135
467705003270	PhoU domain; Region: PhoU; pfam01895
467705003271	PhoU domain; Region: PhoU; pfam01895
467705003272	Aminopeptidase N [Amino acid transport and metabolism]; Region: PepN; COG0308
467705003273	Peptidase M1 Aminopeptidase N family incudes tricorn interacting factor F3, Endoplasmic reticulum aminopeptidase 1 (ERAP1), Aminopeptidase Q (APQ); Region: M1_APN_2; cd09601
467705003274	Zn binding site [ion binding]; other site
467705003275	BioY family; Region: BioY; pfam02632
467705003276	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
467705003277	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
467705003278	active site
467705003279	phosphorylation site [posttranslational modification]
467705003280	intermolecular recognition site; other site
467705003281	dimerization interface [polypeptide binding]; other site
467705003282	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
467705003283	DNA binding site [nucleotide binding]
467705003284	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
467705003285	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
467705003286	dimer interface [polypeptide binding]; other site
467705003287	phosphorylation site [posttranslational modification]
467705003288	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
467705003289	ATP binding site [chemical binding]; other site
467705003290	Mg2+ binding site [ion binding]; other site
467705003291	G-X-G motif; other site
467705003292	Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558
467705003293	cytoplasmic alpha-amylase; Reviewed; Region: PRK09441
467705003294	Alpha amylase catalytic domain found in bacterial and fungal Alpha amylases (also called 1,4-alpha-D-glucan-4-glucanohydrolase); Region: AmyAc_bac_fung_AmyA; cd11318
467705003295	active site
467705003296	Na/Ca binding site [ion binding]; other site
467705003297	catalytic site [active]
467705003298	Domain of unknown function (DUF1939); Region: DUF1939; pfam09154
467705003299	30S ribosomal protein S20; Reviewed; Region: rpsT; PRK00239
467705003300	pantothenate kinase; Provisional; Region: PRK05439
467705003301	Pantothenate kinase (PanK) catalyzes the phosphorylation of pantothenic acid to form 4'-phosphopantothenic, which is the first of five steps in coenzyme A (CoA) biosynthetic pathway. The reaction carried out by this enzyme is a key regulatory point...; Region: PanK; cd02025
467705003302	ATP-binding site [chemical binding]; other site
467705003303	CoA-binding site [chemical binding]; other site
467705003304	Mg2+-binding site [ion binding]; other site
467705003305	16S RNA G1207 methylase RsmC [Translation, ribosomal structure and biogenesis]; Region: RsmC; COG2813
467705003306	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
467705003307	S-adenosylmethionine binding site [chemical binding]; other site
467705003308	pyrimidine-nucleoside phosphorylase; Reviewed; Region: PRK06078
467705003309	Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885
467705003310	Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591
467705003311	Pyrimidine nucleoside phosphorylase C-terminal domain; Region: PYNP_C; pfam07831
467705003312	2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family; Region: DeoC; cd00959
467705003313	intersubunit interface [polypeptide binding]; other site
467705003314	active site
467705003315	catalytic residue [active]
467705003316	Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283
467705003317	active site
467705003318	catalytic motif [active]
467705003319	Zn binding site [ion binding]; other site
467705003320	Uncharacterized ABC-type transport system, periplasmic component/surface lipoprotein [General function prediction only]; Region: Med; COG1744
467705003321	Periplasmic binding domain of basic membrane lipoprotein, PnrA, in Treponema pallidum and its homologs from other bacteria and Archaea; Region: PBP1_BmpA_PnrA_like; cd06354
467705003322	ligand binding site [chemical binding]; other site
467705003323	ABC-type uncharacterized transport systems, ATPase components [General function prediction only]; Region: COG3845
467705003324	First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216
467705003325	Walker A/P-loop; other site
467705003326	ATP binding site [chemical binding]; other site
467705003327	Q-loop/lid; other site
467705003328	ABC transporter signature motif; other site
467705003329	Walker B; other site
467705003330	D-loop; other site
467705003331	H-loop/switch region; other site
467705003332	Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215
467705003333	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
467705003334	Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580
467705003335	TM-ABC transporter signature motif; other site
467705003336	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
467705003337	Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580
467705003338	TM-ABC transporter signature motif; other site
467705003339	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
467705003340	Coenzyme A binding pocket [chemical binding]; other site
467705003341	Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673
467705003342	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
467705003343	Coenzyme A binding pocket [chemical binding]; other site
467705003344	Tellurite resistance protein and related permeases [Inorganic ion transport and metabolism]; Region: TehA; COG1275
467705003345	C4-dicarboxylate transporters of the Tellurite-resistance/Dicarboxylate Transporter (TDT) family; Region: TDT_C4-dicarb_trans; cd09325
467705003346	gating phenylalanine in ion channel; other site
467705003347	Transcriptional regulator [Transcription]; Region: LysR; COG0583
467705003348	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
467705003349	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
467705003350	dimerization interface [polypeptide binding]; other site
467705003351	lipoprotein signal peptidase; Provisional; Region: PRK14797
467705003352	Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564
467705003353	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
467705003354	RNA binding surface [nucleotide binding]; other site
467705003355	Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869
467705003356	active site
467705003357	Uncharacterized protein family (UPF0167); Region: UPF0167; pfam03691
467705003358	bifunctional 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase/phosphatase; Validated; Region: PRK06698
467705003359	acetoin reductase; Validated; Region: PRK08643
467705003360	meso-2,3-butanediol dehydrogenase-like, classical (c) SDRs; Region: meso-BDH-like_SDR_c; cd05366
467705003361	NAD binding site [chemical binding]; other site
467705003362	homotetramer interface [polypeptide binding]; other site
467705003363	homodimer interface [polypeptide binding]; other site
467705003364	active site
467705003365	substrate binding site [chemical binding]; other site
467705003366	gamma-glutamyl kinase; Provisional; Region: PRK05429
467705003367	AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242
467705003368	nucleotide binding site [chemical binding]; other site
467705003369	homotetrameric interface [polypeptide binding]; other site
467705003370	putative phosphate binding site [ion binding]; other site
467705003371	putative allosteric binding site; other site
467705003372	Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079
467705003373	gamma-glutamyl phosphate reductase; Region: proA; TIGR00407
467705003374	putative catalytic cysteine [active]
467705003375	Pyrroline-5-carboxylate reductase [Amino acid transport and metabolism]; Region: ProC; COG0345
467705003376	pyrroline-5-carboxylate reductase; Region: PLN02688
467705003377	Uncharacterized Zn-ribbon-containing protein involved in phosphonate metabolism [Inorganic ion transport and metabolism]; Region: PhnA; COG2824
467705003378	PhnA Zinc-Ribbon; Region: PhnA_Zn_Ribbon; pfam08274
467705003379	PhnA protein; Region: PhnA; pfam03831
467705003380	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cl00309
467705003381	carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564
467705003382	Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; smart01097
467705003383	Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744
467705003384	catalytic site [active]
467705003385	subunit interface [polypeptide binding]; other site
467705003386	carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294
467705003387	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
467705003388	Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786
467705003389	Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787
467705003390	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
467705003391	ATP-grasp domain; Region: ATP-grasp_4; cl17255
467705003392	Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424
467705003393	IMP binding site; other site
467705003394	dimer interface [polypeptide binding]; other site
467705003395	interdomain contacts; other site
467705003396	partial ornithine binding site; other site
467705003397	Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799
467705003398	Pyrimidine operon attenuation protein/uracil phosphoribosyltransferase [Nucleotide transport and metabolism]; Region: PyrR; COG2065
467705003399	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
467705003400	active site
467705003401	uracil transporter; Provisional; Region: PRK10720
467705003402	aspartate carbamoyltransferase catalytic subunit; Provisional; Region: pyrB; PRK00856
467705003403	Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729
467705003404	Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185
467705003405	SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379
467705003406	Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349
467705003407	helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420
467705003408	DeoR C terminal sensor domain; Region: DeoRC; pfam00455
467705003409	Fructose-1-phosphate kinase and related fructose-6-phosphate kinase (PfkB) [Carbohydrate transport and metabolism]; Region: FruK; COG1105
467705003410	1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164
467705003411	putative substrate binding site [chemical binding]; other site
467705003412	putative ATP binding site [chemical binding]; other site
467705003413	PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211
467705003414	active site
467705003415	phosphorylation site [posttranslational modification]
467705003416	PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569
467705003417	active site
467705003418	P-loop; other site
467705003419	phosphorylation site [posttranslational modification]
467705003420	Phosphotransferase system, fructose-specific IIC component [Carbohydrate transport and metabolism]; Region: FruA; cl17425
467705003421	Protein of unknown function (DUF1149); Region: DUF1149; pfam06619
467705003422	EDD domain protein, DegV family; Region: DegV; TIGR00762
467705003423	Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645
467705003424	dihydrodipicolinate reductase; Provisional; Region: PRK00048
467705003425	Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113
467705003426	Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173
467705003427	tRNA CCA-pyrophosphorylase; Provisional; Region: PRK13299
467705003428	Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398
467705003429	active site
467705003430	NTP binding site [chemical binding]; other site
467705003431	metal binding triad [ion binding]; metal-binding site
467705003432	Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627
467705003433	tRNA nucleotidyltransferase domain 2 putative; Region: tRNA_NucTran2_2; pfam13735
467705003434	ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488
467705003435	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
467705003436	Walker A/P-loop; other site
467705003437	ATP binding site [chemical binding]; other site
467705003438	Q-loop/lid; other site
467705003439	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
467705003440	ABC transporter; Region: ABC_tran_2; pfam12848
467705003441	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
467705003442	Divergent AAA domain; Region: AAA_4; pfam04326
467705003443	GMP synthase; Reviewed; Region: guaA; PRK00074
467705003444	Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742
467705003445	AMP/PPi binding site [chemical binding]; other site
467705003446	candidate oxyanion hole; other site
467705003447	catalytic triad [active]
467705003448	potential glutamine specificity residues [chemical binding]; other site
467705003449	The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997
467705003450	ATP Binding subdomain [chemical binding]; other site
467705003451	Dimerization subdomain; other site
467705003452	Transcriptional regulators [Transcription]; Region: PhnF; COG2188
467705003453	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
467705003454	DNA-binding site [nucleotide binding]; DNA binding site
467705003455	UTRA domain; Region: UTRA; pfam07702
467705003456	Putative helix-turn-helix protein, YlxM / p13 like; Region: UPF0122; pfam04297
467705003457	Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569
467705003458	signal recognition particle protein; Provisional; Region: PRK10867
467705003459	SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963
467705003460	The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115
467705003461	P loop; other site
467705003462	GTP binding site [chemical binding]; other site
467705003463	Signal peptide binding domain; Region: SRP_SPB; pfam02978
467705003464	Alpha/beta hydrolase of unknown function (DUF915); Region: DUF915; pfam06028
467705003465	putative PEP-CTERM system TPR-repeat lipoprotein; Region: PEP_TPR_lipo; TIGR02917
467705003466	site-specific tyrosine recombinase XerS; Reviewed; Region: xerS; PRK05084
467705003467	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
467705003468	active site
467705003469	DNA binding site [nucleotide binding]
467705003470	Int/Topo IB signature motif; other site
467705003471	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
467705003472	putative bacteriocin export ABC transporter, lactococcin 972 group; Region: L_ocin_972_ABC; TIGR03608
467705003473	Walker A/P-loop; other site
467705003474	ATP binding site [chemical binding]; other site
467705003475	Q-loop/lid; other site
467705003476	ABC transporter signature motif; other site
467705003477	Walker B; other site
467705003478	D-loop; other site
467705003479	H-loop/switch region; other site
467705003480	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4652
467705003481	Protein of unknown function (DUF1430); Region: DUF1430; pfam07242
467705003482	lipoyltransferase and lipoate-protein ligase; Region: lipoyltrans; TIGR00545
467705003483	Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095
467705003484	Bacterial lipoate protein ligase C-terminus; Region: Lip_prot_lig_C; pfam10437
467705003485	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
467705003486	E3 interaction surface; other site
467705003487	lipoyl attachment site [posttranslational modification]; other site
467705003488	dihydrolipoamide dehydrogenase; Region: lipoamide_DH; TIGR01350
467705003489	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
467705003490	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
467705003491	dihydrolipoamide acetyltransferase; Provisional; Region: PRK14843
467705003492	e3 binding domain; Region: E3_binding; pfam02817
467705003493	e3 binding domain; Region: E3_binding; pfam02817
467705003494	2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198
467705003495	Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022
467705003496	Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036
467705003497	alpha subunit interface [polypeptide binding]; other site
467705003498	TPP binding site [chemical binding]; other site
467705003499	heterodimer interface [polypeptide binding]; other site
467705003500	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
467705003501	Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, alpha subunit [Energy production and conversion]; Region: AcoA; COG1071
467705003502	Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000
467705003503	tetramer interface [polypeptide binding]; other site
467705003504	TPP-binding site [chemical binding]; other site
467705003505	heterodimer interface [polypeptide binding]; other site
467705003506	phosphorylation loop region [posttranslational modification]
467705003507	ATP-grasp domain; Region: ATP-grasp_4; pfam13535
467705003508	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4947
467705003509	Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819
467705003510	Putative esterase; Region: Esterase; pfam00756
467705003511	Formate/nitrite transporter; Region: Form_Nir_trans; cl00927
467705003512	Muramidase (flagellum-specific) [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FlgJ; COG1705
467705003513	YihA (EngB) GTPase family; Region: YihA_EngB; cd01876
467705003514	G1 box; other site
467705003515	GTP/Mg2+ binding site [chemical binding]; other site
467705003516	Switch I region; other site
467705003517	G2 box; other site
467705003518	G3 box; other site
467705003519	Switch II region; other site
467705003520	G4 box; other site
467705003521	G5 box; other site
467705003522	ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342
467705003523	ClpX C4-type zinc finger; Region: zf-C4_ClpX; pfam06689
467705003524	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
467705003525	Walker A motif; other site
467705003526	ATP binding site [chemical binding]; other site
467705003527	Walker B motif; other site
467705003528	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086
467705003529	Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262
467705003530	Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cd00209
467705003531	folate binding site [chemical binding]; other site
467705003532	NADP+ binding site [chemical binding]; other site
467705003533	thymidylate synthase; Reviewed; Region: thyA; PRK01827
467705003534	Thymidylate synthase and pyrimidine hydroxymethylase: Thymidylate synthase (TS) and deoxycytidylate hydroxymethylase (dCMP-HMase) are homologs that catalyze analogous alkylation of C5 of pyrimidine nucleotides. Both enzymes are involved in the...; Region: TS_Pyrimidine_HMase; cd00351
467705003535	dimerization interface [polypeptide binding]; other site
467705003536	active site
467705003537	ROK family protein (putative glucokinase); Region: ROK_glcA_fam; TIGR00744
467705003538	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012
467705003539	nucleotide binding site [chemical binding]; other site
467705003540	Alpha/beta hydrolase of unknown function (DUF915); Region: DUF915; pfam06028
467705003541	CshA-type fibril repeat; Region: CshA_fibril_rpt; TIGR04225
467705003542	CshA-type fibril repeat; Region: CshA_fibril_rpt; TIGR04225
467705003543	CshA-type fibril repeat; Region: CshA_fibril_rpt; TIGR04225
467705003544	CshA-type fibril repeat; Region: CshA_fibril_rpt; TIGR04225
467705003545	CshA-type fibril repeat; Region: CshA_fibril_rpt; TIGR04225
467705003546	CshA-type fibril repeat; Region: CshA_fibril_rpt; TIGR04225
467705003547	CshA-type fibril repeat; Region: CshA_fibril_rpt; TIGR04225
467705003548	CshA-type fibril repeat; Region: CshA_fibril_rpt; TIGR04225
467705003549	CshA-type fibril repeat; Region: CshA_fibril_rpt; TIGR04225
467705003550	CshA-type fibril repeat; Region: CshA_fibril_rpt; TIGR04225
467705003551	CshA-type fibril repeat; Region: CshA_fibril_rpt; TIGR04225
467705003552	CshA-type fibril repeat; Region: CshA_fibril_rpt; TIGR04225
467705003553	CshA-type fibril repeat; Region: CshA_fibril_rpt; TIGR04225
467705003554	CshA-type fibril repeat; Region: CshA_fibril_rpt; TIGR04225
467705003555	CshA-type fibril repeat; Region: CshA_fibril_rpt; TIGR04225
467705003556	Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741
467705003557	Lysozyme-like; Region: Lysozyme_like; pfam13702
467705003558	37-kD nucleoid-associated bacterial protein; Region: NA37; cl15473
467705003559	serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011
467705003560	Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378
467705003561	dimer interface [polypeptide binding]; other site
467705003562	active site
467705003563	glycine-pyridoxal phosphate binding site [chemical binding]; other site
467705003564	folate binding site [chemical binding]; other site
467705003565	Putative translation factor (SUA5) [Translation, ribosomal structure and biogenesis]; Region: SUA5; COG0009
467705003566	protein-(glutamine-N5) methyltransferase, release factor-specific; Region: RF_mod_PrmC; TIGR03534
467705003567	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
467705003568	S-adenosylmethionine binding site [chemical binding]; other site
467705003569	peptide chain release factor 1; Validated; Region: prfA; PRK00591
467705003570	This domain is found in peptide chain release factors; Region: PCRF; smart00937
467705003571	RF-1 domain; Region: RF-1; pfam00472
467705003572	thymidine kinase; Provisional; Region: PRK04296
467705003573	4-oxalocrotonate tautomerase; Provisional; Region: PRK02289
467705003574	active site 1 [active]
467705003575	dimer interface [polypeptide binding]; other site
467705003576	hexamer interface [polypeptide binding]; other site
467705003577	active site 2 [active]
467705003578	xanthine permease; Region: pbuX; TIGR03173
467705003579	Sulfate transporter family; Region: Sulfate_transp; pfam00916
467705003580	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
467705003581	active site
467705003582	guanosine 5'-monophosphate oxidoreductase; Provisional; Region: PRK05458
467705003583	IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381
467705003584	active site
467705003585	multidrug efflux protein; Reviewed; Region: PRK01766
467705003586	Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Vibrio cholerae NorM; Region: MATE_NorM_like; cd13131
467705003587	cation binding site [ion binding]; other site
467705003588	mttA/Hcf106 family; Region: MttA_Hcf106; cl00788
467705003589	Sec-independent protein secretion pathway component TatC [Intracellular trafficking and secretion]; Region: TatC; COG0805
467705003590	High-affinity Fe2+/Pb2+ permease [Inorganic ion transport and metabolism]; Region: FTR1; COG0672
467705003591	Predicted iron-dependent peroxidase [Inorganic ion transport and metabolism]; Region: COG2837
467705003592	Imelysin; Region: Peptidase_M75; pfam09375
467705003593	ClC chloride channel EriC.  This domain is found in the EriC chloride transporters that mediate the extreme acid resistance response in eubacteria and archaea. This response allows bacteria to survive in the acidic environments by decarboxylation-linked...; Region: EriC; cd01031
467705003594	Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038
467705003595	Cl- selectivity filter; other site
467705003596	Cl- binding residues [ion binding]; other site
467705003597	pore gating glutamate residue; other site
467705003598	dimer interface [polypeptide binding]; other site
467705003599	H+/Cl- coupling transport residue; other site
467705003600	TrkA-C domain; Region: TrkA_C; pfam02080
467705003601	coenzyme A disulfide reductase; Reviewed; Region: PRK09564
467705003602	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
467705003603	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
467705003604	Membrane-associated lipoprotein involved in thiamine biosynthesis [Coenzyme metabolism]; Region: ApbE; COG1477
467705003605	ApbE family; Region: ApbE; pfam02424
467705003606	Predicted flavoprotein [General function prediction only]; Region: COG0431
467705003607	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
467705003608	Predicted flavoprotein [General function prediction only]; Region: COG0431
467705003609	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
467705003610	PAS domain; Region: PAS_10; pfam13596
467705003611	TlpA-like family; composed of  TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966
467705003612	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
467705003613	catalytic residues [active]
467705003614	Cytochrome c biogenesis protein [Posttranslational modification, protein turnover, chaperones]; Region: CcdA; COG0785
467705003615	Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788
467705003616	Predicted signal transduction protein with a C-terminal ATPase domain [Signal transduction mechanisms]; Region: COG2972
467705003617	Cache domain; Region: Cache_1; pfam02743
467705003618	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
467705003619	dimerization interface [polypeptide binding]; other site
467705003620	Histidine kinase; Region: His_kinase; pfam06580
467705003621	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
467705003622	ATP binding site [chemical binding]; other site
467705003623	Mg2+ binding site [ion binding]; other site
467705003624	G-X-G motif; other site
467705003625	Response regulator receiver domain; Region: Response_reg; pfam00072
467705003626	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
467705003627	active site
467705003628	phosphorylation site [posttranslational modification]
467705003629	intermolecular recognition site; other site
467705003630	dimerization interface [polypeptide binding]; other site
467705003631	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
467705003632	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
467705003633	Peptide methionine sulfoxide reductase [Posttranslational modification, protein turnover, chaperones]; Region: MsrA; COG0225
467705003634	Conserved domain frequently associated with peptide methionine sulfoxide reductase [Posttranslational modification, protein turnover, chaperones]; Region: COG0229
467705003635	SelR domain; Region: SelR; pfam01641
467705003636	TlpA-like family; composed of  TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966
467705003637	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
467705003638	catalytic residues [active]
467705003639	Cytochrome c biogenesis protein [Posttranslational modification, protein turnover, chaperones]; Region: CcdA; COG0785
467705003640	Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788
467705003641	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
467705003642	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
467705003643	dimerization interface [polypeptide binding]; other site
467705003644	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
467705003645	dimer interface [polypeptide binding]; other site
467705003646	phosphorylation site [posttranslational modification]
467705003647	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
467705003648	ATP binding site [chemical binding]; other site
467705003649	Mg2+ binding site [ion binding]; other site
467705003650	G-X-G motif; other site
467705003651	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
467705003652	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
467705003653	active site
467705003654	phosphorylation site [posttranslational modification]
467705003655	intermolecular recognition site; other site
467705003656	dimerization interface [polypeptide binding]; other site
467705003657	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
467705003658	DNA binding site [nucleotide binding]
467705003659	Fibronectin-binding repeat; Region: SSURE; pfam11966
467705003660	Fibronectin-binding repeat; Region: SSURE; pfam11966
467705003661	Fibronectin-binding repeat; Region: SSURE; pfam11966
467705003662	Branched-chain amino acid transport protein; Region: Branch_AA_trans; pfam05525
467705003663	Uncharacterized conserved protein [Function unknown]; Region: COG1434
467705003664	YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259
467705003665	putative active site [active]
467705003666	Acetyltransferases [General function prediction only]; Region: RimI; COG0456
467705003667	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
467705003668	Coenzyme A binding pocket [chemical binding]; other site
467705003669	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
467705003670	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
467705003671	ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254
467705003672	Walker A/P-loop; other site
467705003673	ATP binding site [chemical binding]; other site
467705003674	Q-loop/lid; other site
467705003675	ABC transporter signature motif; other site
467705003676	Walker B; other site
467705003677	D-loop; other site
467705003678	H-loop/switch region; other site
467705003679	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
467705003680	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
467705003681	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
467705003682	Walker A/P-loop; other site
467705003683	ATP binding site [chemical binding]; other site
467705003684	Q-loop/lid; other site
467705003685	ABC transporter signature motif; other site
467705003686	Walker B; other site
467705003687	D-loop; other site
467705003688	H-loop/switch region; other site
467705003689	Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387
467705003690	core dimer interface [polypeptide binding]; other site
467705003691	L10 interface [polypeptide binding]; other site
467705003692	L11 interface [polypeptide binding]; other site
467705003693	putative EF-Tu interaction site [polypeptide binding]; other site
467705003694	putative EF-G interaction site [polypeptide binding]; other site
467705003695	Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797
467705003696	23S rRNA interface [nucleotide binding]; other site
467705003697	Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site
467705003698	tRNA (uracil-5-)-methyltransferase Gid; Reviewed; Region: PRK05335
467705003699	Glucose inhibited division protein A; Region: GIDA; pfam01134
467705003700	Protein of unknown function (DUF3307); Region: DUF3307; pfam11750
467705003701	DNA topoisomerase I; Validated; Region: PRK05582
467705003702	TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I.   Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363
467705003703	active site
467705003704	interdomain interaction site; other site
467705003705	putative metal-binding site [ion binding]; other site
467705003706	nucleotide binding site [chemical binding]; other site
467705003707	DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186
467705003708	domain I; other site
467705003709	DNA binding groove [nucleotide binding]
467705003710	phosphate binding site [ion binding]; other site
467705003711	domain II; other site
467705003712	domain III; other site
467705003713	nucleotide binding site [chemical binding]; other site
467705003714	catalytic site [active]
467705003715	domain IV; other site
467705003716	Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396
467705003717	Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396
467705003718	DNA recombination-mediator protein A; Region: DNA_processg_A; pfam02481
467705003719	DNA protecting protein DprA; Region: dprA; TIGR00732
467705003720	maltose O-acetyltransferase; Provisional; Region: PRK10092
467705003721	Maltose O-acetyltransferase (MAT) and Galactoside O-acetyltransferase (GAT): MAT and GAT catalyze the CoA-dependent acetylation of the 6-hydroxyl group of their respective sugar substrates. MAT acetylates maltose and glucose exclusively at the C6...; Region: LbH_MAT_GAT; cd03357
467705003722	active site
467705003723	substrate binding site [chemical binding]; other site
467705003724	trimer interface [polypeptide binding]; other site
467705003725	CoA binding site [chemical binding]; other site
467705003726	transcriptional antiterminator BglG; Provisional; Region: PRK09772
467705003727	CAT RNA binding domain; Region: CAT_RBD; smart01061
467705003728	PRD domain; Region: PRD; pfam00874
467705003729	PRD domain; Region: PRD; pfam00874
467705003730	bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182
467705003731	RNA/DNA hybrid binding site [nucleotide binding]; other site
467705003732	active site
467705003733	GTPase YlqF; Reviewed; Region: rbgA; PRK09563
467705003734	Circularly permuted YlqF GTPase; Region: YlqF; cd01856
467705003735	GTP/Mg2+ binding site [chemical binding]; other site
467705003736	G4 box; other site
467705003737	G5 box; other site
467705003738	G1 box; other site
467705003739	Switch I region; other site
467705003740	G2 box; other site
467705003741	G3 box; other site
467705003742	Switch II region; other site
467705003743	ATP cone domain; Region: ATP-cone; pfam03477
467705003744	Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950
467705003745	Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329
467705003746	dimer interface [polypeptide binding]; other site
467705003747	active site
467705003748	catalytic residue [active]
467705003749	aspartate-semialdehyde dehydrogenase; Provisional; Region: PRK14874
467705003750	Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859
467705003751	DNA alkylation repair enzyme; Region: DNA_alkylation; pfam08713
467705003752	A new structural DNA glycosylase containing HEAT-like repeats; Region: AlkD_like_1; cd07064
467705003753	active site
467705003754	Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247
467705003755	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
467705003756	Coenzyme A binding pocket [chemical binding]; other site
467705003757	formate--tetrahydrofolate ligase; Provisional; Region: PRK13505
467705003758	Formyltetrahydrofolate synthetase (FTHFS) catalyzes the ATP-dependent activation of formate ion via its addition to the N10 position of tetrahydrofolate. FTHFS is a highly expressed key enzyme in both the Wood-Ljungdahl pathway of autotrophic CO2...; Region: FTHFS; cd00477
467705003759	Potassium binding sites [ion binding]; other site
467705003760	Cesium cation binding sites [ion binding]; other site
467705003761	phosphopantothenate--cysteine ligase; Validated; Region: PRK06732
467705003762	phosphopantothenoylcysteine decarboxylase; Validated; Region: PRK07313
467705003763	Flavoprotein; Region: Flavoprotein; pfam02441
467705003764	Predicted membrane protein [Function unknown]; Region: COG4684
467705003765	This CD includes PGM2 (phosphoglucomutase 2) and PGM2L1 (phosphoglucomutase 2-like 1). The mammalian PGM2 is thought to be a phosphopentomutase that catalyzes the conversion of the nucleoside breakdown products, ribose-1-phosphate and...; Region: PGM2; cd05799
467705003766	Phosphomannomutase [Carbohydrate transport and metabolism]; Region: {ManB}; COG1109
467705003767	active site
467705003768	substrate binding site [chemical binding]; other site
467705003769	metal binding site [ion binding]; metal-binding site
467705003770	TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947
467705003771	catalytic residues [active]
467705003772	A/G-specific DNA glycosylase [DNA replication, recombination, and repair]; Region: MutY; COG1194
467705003773	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056
467705003774	minor groove reading motif; other site
467705003775	helix-hairpin-helix signature motif; other site
467705003776	substrate binding pocket [chemical binding]; other site
467705003777	active site
467705003778	DNA glycosylase (MutY in bacteria and hMYH in humans) is responsible for repairing misread  A*oxoG residues to C*G by removing the inappropriately paired adenine base from the DNA backbone. It belongs to the Nudix hydrolase superfamily and is important...; Region: DNA_Glycosylase_C; cd03431
467705003779	DNA binding and oxoG recognition site [nucleotide binding]
467705003780	phosphotransacetylase; Reviewed; Region: eutD; PRK09653
467705003781	Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564
467705003782	Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869
467705003783	active site
467705003784	inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK04885
467705003785	ATP-NAD kinase; Region: NAD_kinase; pfam01513
467705003786	Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399
467705003787	synthetase active site [active]
467705003788	NTP binding site [chemical binding]; other site
467705003789	metal binding site [ion binding]; metal-binding site
467705003790	Uncharacterized subgroup 1 of the CYTH-like superfamily; Region: CYTH-like_Pase_1; cd07762
467705003791	putative active site [active]
467705003792	putative metal binding residues [ion binding]; other site
467705003793	signature motif; other site
467705003794	putative triphosphate binding site [ion binding]; other site
467705003795	ribose-phosphate pyrophosphokinase; Provisional; Region: PRK02458
467705003796	N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793
467705003797	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
467705003798	active site
467705003799	Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104
467705003800	cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402
467705003801	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
467705003802	catalytic residue [active]
467705003803	Putative amino acid metabolism; Region: DUF1831; pfam08866
467705003804	redox-sensing transcriptional repressor Rex; Provisional; Region: PRK05472
467705003805	Putative DNA-binding protein N-terminus; Region: Put_DNA-bind_N; pfam06971
467705003806	CoA binding domain; Region: CoA_binding; pfam02629
467705003807	hypothetical protein; Reviewed; Region: PRK00024
467705003808	Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071
467705003809	MPN+ (JAMM) motif; other site
467705003810	Zinc-binding site [ion binding]; other site
467705003811	Sortase A (SrtA) or subfamily-1 sortases are cysteine transpeptidases found in gram-positive bacteria that anchor surface proteins to peptidoglycans of the bacterial cell wall envelope. They do so by catalyzing a transpeptidation reaction in which the...; Region: Sortase_A_1; cd06165
467705003812	active site
467705003813	catalytic site [active]
467705003814	DNA gyrase subunit A; Validated; Region: PRK05560
467705003815	DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187
467705003816	CAP-like domain; other site
467705003817	active site
467705003818	primary dimer interface [polypeptide binding]; other site
467705003819	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
467705003820	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
467705003821	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
467705003822	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
467705003823	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
467705003824	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
467705003825	L-lactate dehydrogenase; Reviewed; Region: ldh; PRK00066
467705003826	L-2-hydroxyisocapronate dehydrogenases and some bacterial L-lactate dehydrogenases; Region: HicDH_like; cd05291
467705003827	tetramer (dimer of dimers) interface [polypeptide binding]; other site
467705003828	NAD binding site [chemical binding]; other site
467705003829	dimer interface [polypeptide binding]; other site
467705003830	substrate binding site [chemical binding]; other site
467705003831	30S ribosomal protein S1; Reviewed; Region: rpsA; PRK06676
467705003832	S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687
467705003833	RNA binding site [nucleotide binding]; other site
467705003834	S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465
467705003835	RNA binding site [nucleotide binding]; other site
467705003836	S1_RPS1_repeat_ec3: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec3; cd05688
467705003837	RNA binding site [nucleotide binding]; other site
467705003838	S1_RPS1_repeat_hs4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_hs4; cd05692
467705003839	RNA binding site [nucleotide binding]; other site
467705003840	Protein of unknown function (DUF2969); Region: DUF2969; pfam11184
467705003841	branched-chain amino acid aminotransferase; Provisional; Region: PRK13357
467705003842	BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids  leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557
467705003843	homodimer interface [polypeptide binding]; other site
467705003844	substrate-cofactor binding pocket; other site
467705003845	catalytic residue [active]
467705003846	DNA topoisomerase IV, A subunit, Gram-positive; Region: parC_Gpos; TIGR01061
467705003847	DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187
467705003848	CAP-like domain; other site
467705003849	active site
467705003850	primary dimer interface [polypeptide binding]; other site
467705003851	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
467705003852	CAAX protease self-immunity; Region: Abi; pfam02517
467705003853	Streptomycin adenylyltransferase; Region: Adenyl_transf; pfam04439
467705003854	Prokaryotic membrane lipoprotein lipid attachment site; Region: LPAM_1; pfam08139
467705003855	DNA topoisomerase IV, B subunit, Gram-positive; Region: parE_Gpos; TIGR01058
467705003856	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
467705003857	Mg2+ binding site [ion binding]; other site
467705003858	G-X-G motif; other site
467705003859	TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822
467705003860	anchoring element; other site
467705003861	dimer interface [polypeptide binding]; other site
467705003862	ATP binding site [chemical binding]; other site
467705003863	TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366
467705003864	active site
467705003865	putative metal-binding site [ion binding]; other site
467705003866	DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986
467705003867	putative glycerol-3-phosphate acyltransferase PlsY; Provisional; Region: PRK00220
467705003868	NAD pyrophosphatase/5'-nucleotidase NadN; Region: nadN; TIGR01530
467705003869	Staphylococcus aureus SA0022 and related proteins, N-terminal metallophosphatase domain; Region: MPP_SA0022_N; cd07408
467705003870	putative active site [active]
467705003871	putative metal binding site [ion binding]; other site
467705003872	5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872
467705003873	dihydroorotase; Validated; Region: pyrC; PRK09357
467705003874	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
467705003875	Dihydroorotase (DHOase), subgroup IIa; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This subgroup also contains proteins that lack the active site, like unc-33, a C; Region: DHOase_IIa; cd01317
467705003876	active site
467705003877	MutT homolog-1 (MTH1) is a member of the Nudix hydrolase superfamily. MTH1, the mammalian counterpart of MutT, hydrolyzes oxidized purine nucleoside triphosphates, such as 8-oxo-dGTP and 2-hydroxy-ATP, to monophosphates, thereby preventing the...; Region: MTH1; cd03427
467705003878	putative active site [active]
467705003879	nucleotide binding site [chemical binding]; other site
467705003880	nudix motif; other site
467705003881	putative metal binding site [ion binding]; other site
467705003882	Family 1 of Uracil-DNA glycosylase (UDG) enzymes; Region: UDG_F1; cd10027
467705003883	ligand binding site [chemical binding]; other site
467705003884	active site
467705003885	UGI interface [polypeptide binding]; other site
467705003886	catalytic site [active]
467705003887	Domain of unknown function (DUF4336); Region: DUF4336; pfam14234
467705003888	conserved hypothetical integral membrane protein; Region: TIGR03766
467705003889	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
467705003890	active site
467705003891	Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725
467705003892	active site
467705003893	dimer interface [polypeptide binding]; other site
467705003894	dihydroorotate dehydrogenase (subfamily 1) family protein; Region: pyrD_sub1_fam; TIGR01037
467705003895	Dihydroorotate dehydrogenase (DHOD) class 1B FMN-binding domain. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine...; Region: DHOD_1B_like; cd04740
467705003896	heterodimer interface [polypeptide binding]; other site
467705003897	active site
467705003898	FMN binding site [chemical binding]; other site
467705003899	homodimer interface [polypeptide binding]; other site
467705003900	substrate binding site [chemical binding]; other site
467705003901	dihydroorotate dehydrogenase electron transfer subunit; Reviewed; Region: PRK00054
467705003902	FAD/NAD binding domain in the electron transfer subunit of dihydroorotate dehydrogenase. Dihydroorotate dehydrogenases (DHODs) catalyze the only redox reaction in pyrimidine de novo biosynthesis. They catalyze the oxidation of (S)-dihydroorotate to...; Region: DHOD_e_trans; cd06218
467705003903	FAD binding pocket [chemical binding]; other site
467705003904	FAD binding motif [chemical binding]; other site
467705003905	phosphate binding motif [ion binding]; other site
467705003906	beta-alpha-beta structure motif; other site
467705003907	NAD binding pocket [chemical binding]; other site
467705003908	Iron coordination center [ion binding]; other site
467705003909	Transcriptional regulator [Transcription]; Region: LysR; COG0583
467705003910	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
467705003911	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
467705003912	dimerization interface [polypeptide binding]; other site
467705003913	NAD-dependent deacetylase; Provisional; Region: PRK00481
467705003914	SIR2 superfamily of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+; Region: SIR2; cl00195
467705003915	CRISPR/Cas system-associated protein Csm6; Region: Csm6_III-A; cl09873
467705003916	purine nucleoside phosphorylase; Reviewed; Region: deoD; PRK05819
467705003917	GMP synthase - Glutamine amidotransferase domain [Nucleotide transport and metabolism]; Region: GuaA; COG0518
467705003918	Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_1; cd01741
467705003919	catalytic triad [active]
467705003920	Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038
467705003921	Putative ClC chloride channel.  Clc proteins are putative halogen ion (Cl-, Br- and I-) transporters found in eubacteria. They belong to the ClC superfamily of halogen ion channels, which share a unique double-barreled architecture and voltage-dependent...; Region: ClC_like; cd01033
467705003922	putative ion selectivity filter; other site
467705003923	putative pore gating glutamate residue; other site
467705003924	purine nucleoside phosphorylase; Provisional; Region: PRK08202
467705003925	phosphopentomutase; Provisional; Region: PRK05362
467705003926	Metalloenzyme superfamily; Region: Metalloenzyme; pfam01676
467705003927	RPI_A: Ribose 5-phosphate isomerase type A (RPI_A) subfamily; RPI catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate, the first step of the non-oxidative branch of the pentose phosphate pathway. This reaction leads to the...; Region: RPI_A; cd01398
467705003928	tetramer (dimer of dimers) interface [polypeptide binding]; other site
467705003929	active site
467705003930	dimer interface [polypeptide binding]; other site
467705003931	tRNA modification GTPase TrmE; Reviewed; Region: trmE; PRK05291
467705003932	GTP-binding protein TrmE N-terminus; Region: TrmE_N; pfam10396
467705003933	trmE is a tRNA modification GTPase; Region: trmE; cd04164
467705003934	G1 box; other site
467705003935	GTP/Mg2+ binding site [chemical binding]; other site
467705003936	Switch I region; other site
467705003937	G2 box; other site
467705003938	Switch II region; other site
467705003939	G3 box; other site
467705003940	G4 box; other site
467705003941	G5 box; other site
467705003942	Catalytic cysteine-containing C-terminus of GTPase, MnmE; Region: GTPase_Cys_C; pfam12631
467705003943	TlpA-like family; composed of  TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966
467705003944	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
467705003945	catalytic residues [active]
467705003946	LrgB-like family; Region: LrgB; pfam04172
467705003947	Putative effector of murein hydrolase LrgA [General function prediction only]; Region: COG1380
467705003948	Predicted metal-sulfur cluster biosynthetic enzyme [General function prediction only]; Region: PaaD; COG2151
467705003949	RNA polymerase sigma factor RpoD; Validated; Region: PRK09210
467705003950	Sigma-70 factor, region 1.1; Region: Sigma70_r1_1; pfam03979
467705003951	Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140
467705003952	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
467705003953	Sigma-70 region 3; Region: Sigma70_r3; pfam04539
467705003954	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
467705003955	DNA binding residues [nucleotide binding]
467705003956	DNA primase; Validated; Region: dnaG; PRK05667
467705003957	CHC2 zinc finger; Region: zf-CHC2; pfam01807
467705003958	DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275
467705003959	TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364
467705003960	active site
467705003961	metal binding site [ion binding]; metal-binding site
467705003962	interdomain interaction site; other site
467705003963	DnaB-helicase binding domain of primase; Region: DnaB_bind; pfam10410
467705003964	Large-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscL; COG1970
467705003965	large-conductance mechanosensitive channel; Reviewed; Region: mscL; PRK00567
467705003966	30S ribosomal protein S21; Reviewed; Region: rpsU; PRK00270
467705003967	CYTH-like (also known as triphosphate tunnel metalloenzyme (TTM)-like) Phosphatases; Region: CYTH-like_Pase; cl11964
467705003968	putative metal binding residues [ion binding]; other site
467705003969	CYTH-like (also known as triphosphate tunnel metalloenzyme (TTM)-like) Phosphatases; Region: CYTH-like_Pase; cl11964
467705003970	putative active site; other site
467705003971	signature motif; other site
467705003972	putative triphosphate binding site [ion binding]; other site
467705003973	BlaR1 peptidase M56; Region: Peptidase_M56; pfam05569
467705003974	Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413
467705003975	Penicillinase repressor; Region: Pencillinase_R; pfam03965
467705003976	Protein of unknown function (DUF1304); Region: DUF1304; pfam06993
467705003977	pyridine nucleotide-disulfide oxidoreductase; Provisional; Region: PRK07251
467705003978	ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314
467705003979	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
467705003980	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
467705003981	Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492
467705003982	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
467705003983	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
467705003984	ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488
467705003985	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
467705003986	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
467705003987	Walker A/P-loop; other site
467705003988	ATP binding site [chemical binding]; other site
467705003989	Q-loop/lid; other site
467705003990	ABC transporter signature motif; other site
467705003991	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
467705003992	Walker B; other site
467705003993	Walker B; other site
467705003994	D-loop; other site
467705003995	D-loop; other site
467705003996	H-loop/switch region; other site
467705003997	H-loop/switch region; other site
467705003998	TraX protein; Region: TraX; cl05434
467705003999	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
467705004000	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
467705004001	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
467705004002	Major Facilitator Superfamily; Region: MFS_1; pfam07690
467705004003	putative substrate translocation pore; other site
467705004004	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
467705004005	Domain of unknown function (DUF4098); Region: DUF4098; pfam13345
467705004006	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
467705004007	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
467705004008	ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254
467705004009	Walker A/P-loop; other site
467705004010	ATP binding site [chemical binding]; other site
467705004011	Q-loop/lid; other site
467705004012	ABC transporter signature motif; other site
467705004013	Walker B; other site
467705004014	D-loop; other site
467705004015	H-loop/switch region; other site
467705004016	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
467705004017	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
467705004018	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
467705004019	Walker A/P-loop; other site
467705004020	ATP binding site [chemical binding]; other site
467705004021	Q-loop/lid; other site
467705004022	ABC transporter signature motif; other site
467705004023	Walker B; other site
467705004024	D-loop; other site
467705004025	H-loop/switch region; other site
467705004026	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
467705004027	Major Facilitator Superfamily; Region: MFS_1; pfam07690
467705004028	putative substrate translocation pore; other site
467705004029	asparaginyl-tRNA synthetase; Validated; Region: asnC; PRK03932
467705004030	AsnRS_cyto_like_N: N-terminal, anticodon recognition domain of the type found in human and Saccharomyces cerevisiae cytoplasmic asparaginyl-tRNA synthetase (AsnRS), in Brugia malayai AsnRs and, in various putative bacterial AsnRSs.  This domain is a...; Region: AsnRS_cyto_like_N; cd04323
467705004031	putative dimer interface [polypeptide binding]; other site
467705004032	putative anticodon binding site; other site
467705004033	Asx tRNA synthetase (AspRS/AsnRS) class II core domain.  Assignment to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs in the core domain. This family includes AsnRS as well as...; Region: AsxRS_core; cd00776
467705004034	homodimer interface [polypeptide binding]; other site
467705004035	motif 1; other site
467705004036	motif 2; other site
467705004037	active site
467705004038	motif 3; other site
467705004039	aspartate aminotransferase; Provisional; Region: PRK05764
467705004040	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
467705004041	pyridoxal 5'-phosphate binding site [chemical binding]; other site
467705004042	homodimer interface [polypeptide binding]; other site
467705004043	catalytic residue [active]
467705004044	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5353
467705004045	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
467705004046	MarR family; Region: MarR; pfam01047
467705004047	Predicted flavoprotein [General function prediction only]; Region: COG0431
467705004048	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
467705004049	Beta-fructosidases (levanase/invertase) [Carbohydrate transport and metabolism]; Region: SacC; COG1621
467705004050	Glycosyl hydrolase family 32, beta-fructosidases; Region: GH32_B_Fructosidase; cd08996
467705004051	substrate binding [chemical binding]; other site
467705004052	active site
467705004053	Glycosyl hydrolases family 32 C terminal; Region: Glyco_hydro_32C; pfam08244
467705004054	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
467705004055	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
467705004056	dimer interface [polypeptide binding]; other site
467705004057	conserved gate region; other site
467705004058	putative PBP binding loops; other site
467705004059	ABC-ATPase subunit interface; other site
467705004060	ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209
467705004061	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
467705004062	putative PBP binding loops; other site
467705004063	dimer interface [polypeptide binding]; other site
467705004064	ABC-ATPase subunit interface; other site
467705004065	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
467705004066	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
467705004067	Transcriptional regulators [Transcription]; Region: PurR; COG1609
467705004068	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
467705004069	DNA binding site [nucleotide binding]
467705004070	domain linker motif; other site
467705004071	Ligand binding domain of the lacI-like transcription regulator from a novel metal-reducing bacterium Alkaliphilus Metalliredigens (strain Qymf) and its close homologs; Region: PBP1_Qymf_like; cd06291
467705004072	dimerization interface [polypeptide binding]; other site
467705004073	ligand binding site [chemical binding]; other site
467705004074	sodium binding site [ion binding]; other site
467705004075	hypothetical protein; Validated; Region: PRK02101
467705004076	Domain of unknown function (DUF1836); Region: DUF1836; pfam08876
467705004077	Predicted membrane protein, hemolysin III homolog [General function prediction only]; Region: COG1272
467705004078	channel protein, hemolysin III family; Region: hlyIII; TIGR01065
467705004079	Protoheme ferro-lyase (ferrochelatase) [Coenzyme metabolism]; Region: HemH; COG0276
467705004080	Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411
467705004081	C-terminal domain interface [polypeptide binding]; other site
467705004082	active site
467705004083	Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419
467705004084	active site
467705004085	N-terminal domain interface [polypeptide binding]; other site
467705004086	peptidase T; Region: peptidase-T; TIGR01882
467705004087	M20 Peptidase T specifically cleaves tripeptides; Region: M20_peptT; cd03892
467705004088	metal binding site [ion binding]; metal-binding site
467705004089	dimer interface [polypeptide binding]; other site
467705004090	streptococcal histidine triad protein; Region: strep_his_triad; TIGR01363
467705004091	Streptococcal histidine triad protein; Region: Strep_his_triad; pfam04270
467705004092	Streptococcal histidine triad protein; Region: Strep_his_triad; pfam04270
467705004093	Streptococcal histidine triad protein; Region: Strep_his_triad; pfam04270
467705004094	Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+.  Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262
467705004095	Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297
467705004096	intersubunit interface [polypeptide binding]; other site
467705004097	tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026
467705004098	16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK00122
467705004099	RimM N-terminal domain; Region: RimM; pfam01782
467705004100	PRC-barrel domain; Region: PRC; pfam05239
467705004101	Acetyltransferase (GNAT) domain; Region: Acetyltransf_7; pfam13508
467705004102	Coenzyme A binding pocket [chemical binding]; other site
467705004103	K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569
467705004104	TrkA-N domain; Region: TrkA_N; pfam02254
467705004105	Trk-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: TrkG; COG0168
467705004106	potassium uptake protein, TrkH family; Region: 2a38; TIGR00933
467705004107	Predicted RNA-binding protein (contains KH domain) [General function prediction only]; Region: COG1837
467705004108	KH domain; Region: KH_4; pfam13083
467705004109	G-X-X-G motif; other site
467705004110	Ribosomal protein S16 [Translation, ribosomal structure and biogenesis]; Region: RpsP; COG0228
467705004111	CAAX protease self-immunity; Region: Abi; pfam02517
467705004112	Protein of unknown function (DUF1461); Region: DUF1461; cl01862
467705004113	HAD-superfamily subfamily IIA hydrolase, TIGR01457; Region: HAD-SF-IIA-hyp2
467705004114	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
467705004115	active site
467705004116	motif I; other site
467705004117	motif II; other site
467705004118	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
467705004119	Acyl-ACP thioesterase [Lipid metabolism]; Region: FatA; COG3884
467705004120	4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586
467705004121	active site
467705004122	The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509
467705004123	active site 2 [active]
467705004124	active site 1 [active]
467705004125	coproporphyrinogen III oxidase; Provisional; Region: PRK08599
467705004126	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
467705004127	FeS/SAM binding site; other site
467705004128	HemN C-terminal domain; Region: HemN_C; pfam06969
467705004129	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
467705004130	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
467705004131	ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251
467705004132	Walker A/P-loop; other site
467705004133	ATP binding site [chemical binding]; other site
467705004134	Q-loop/lid; other site
467705004135	ABC transporter signature motif; other site
467705004136	Walker B; other site
467705004137	D-loop; other site
467705004138	H-loop/switch region; other site
467705004139	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
467705004140	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
467705004141	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
467705004142	Walker A/P-loop; other site
467705004143	ATP binding site [chemical binding]; other site
467705004144	Q-loop/lid; other site
467705004145	ABC transporter signature motif; other site
467705004146	Walker B; other site
467705004147	D-loop; other site
467705004148	H-loop/switch region; other site
467705004149	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
467705004150	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
467705004151	Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673
467705004152	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
467705004153	Coenzyme A binding pocket [chemical binding]; other site
467705004154	O-acetylhomoserine sulfhydrylase [Amino acid transport and metabolism]; Region: MET17; COG2873
467705004155	CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614
467705004156	homodimer interface [polypeptide binding]; other site
467705004157	substrate-cofactor binding pocket; other site
467705004158	pyridoxal 5'-phosphate binding site [chemical binding]; other site
467705004159	catalytic residue [active]
467705004160	Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447
467705004161	nudix motif; other site
467705004162	ATP-dependent DNA helicase PcrA; Region: pcrA; TIGR01073
467705004163	Part of AAA domain; Region: AAA_19; pfam13245
467705004164	Family description; Region: UvrD_C_2; pfam13538
467705004165	Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053
467705004166	Cation efflux family; Region: Cation_efflux; pfam01545
467705004167	signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227
467705004168	The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530
467705004169	pyruvate kinase; Provisional; Region: PRK05826
467705004170	Pyruvate kinase (PK):  Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342
467705004171	domain interfaces; other site
467705004172	active site
467705004173	Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to a subfamily of the PFKA family (cd00363) and include bacterial ATP-dependent...; Region: Bacterial_PFK; cd00763
467705004174	6-phosphofructokinase; Region: PFKA_ATP; TIGR02482
467705004175	active site
467705004176	ADP/pyrophosphate binding site [chemical binding]; other site
467705004177	dimerization interface [polypeptide binding]; other site
467705004178	allosteric effector site; other site
467705004179	fructose-1,6-bisphosphate binding site; other site
467705004180	DNA polymerase III DnaE; Reviewed; Region: dnaE; PRK07279
467705004181	Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III; Region: PHP_PolIIIA; cd07431
467705004182	active site
467705004183	PHP Thumb interface [polypeptide binding]; other site
467705004184	DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485
467705004185	generic binding surface II; other site
467705004186	generic binding surface I; other site
467705004187	ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555
467705004188	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
467705004189	Walker A/P-loop; other site
467705004190	ATP binding site [chemical binding]; other site
467705004191	Q-loop/lid; other site
467705004192	ABC transporter signature motif; other site
467705004193	Walker B; other site
467705004194	D-loop; other site
467705004195	H-loop/switch region; other site
467705004196	Domain of unknown function (DUF4300); Region: DUF4300; pfam14133
467705004197	Protein of unknown function (DUF1706); Region: DUF1706; pfam08020
467705004198	N-terminal Early set domain associated with the catalytic domain of cyclomaltodextrinase and pullulan-degrading enzymes; Region: E_set_CDase_PDE_N; cd02857
467705004199	homodimer interface [polypeptide binding]; other site
467705004200	Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366
467705004201	Alpha amylase catalytic domain found in cyclomaltodextrinases and related proteins; Region: AmyAc_CMD; cd11338
467705004202	active site
467705004203	homodimer interface [polypeptide binding]; other site
467705004204	catalytic site [active]
467705004205	Protein of unknown function (DUF443); Region: DUF443; cl04467
467705004206	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
467705004207	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
467705004208	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
467705004209	ATP-binding cassette domain of multidrug resistance protein-like transporters; Region: ABCC_MRP_Like; cd03228
467705004210	Walker A/P-loop; other site
467705004211	ATP binding site [chemical binding]; other site
467705004212	Q-loop/lid; other site
467705004213	ABC transporter signature motif; other site
467705004214	Walker B; other site
467705004215	D-loop; other site
467705004216	H-loop/switch region; other site
467705004217	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
467705004218	non-specific DNA binding site [nucleotide binding]; other site
467705004219	salt bridge; other site
467705004220	sequence-specific DNA binding site [nucleotide binding]; other site
467705004221	transcriptional activator, Rgg/GadR/MutR family, C-terminal domain; Region: RGG_Cterm; TIGR01716
467705004222	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
467705004223	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
467705004224	Walker A/P-loop; other site
467705004225	ATP binding site [chemical binding]; other site
467705004226	Q-loop/lid; other site
467705004227	ABC transporter signature motif; other site
467705004228	Walker B; other site
467705004229	D-loop; other site
467705004230	ADP-ribosylglycohydrolase [Posttranslational modification, protein turnover, chaperones]; Region: DraG; COG1397
467705004231	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
467705004232	SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase [Translation, ribosomal structure and biogenesis]; Region: TrmA; COG2265
467705004233	TRAM domain; Region: TRAM; cl01282
467705004234	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
467705004235	S-adenosylmethionine binding site [chemical binding]; other site
467705004236	Transcriptional regulator [Transcription]; Region: LytR; COG1316
467705004237	prephenate dehydratase; Provisional; Region: PRK11898
467705004238	Prephenate dehydratase; Region: PDT; pfam00800
467705004239	C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905
467705004240	putative L-Phe binding site [chemical binding]; other site
467705004241	shikimate kinase; Reviewed; Region: aroK; PRK00131
467705004242	Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464
467705004243	ADP binding site [chemical binding]; other site
467705004244	magnesium binding site [ion binding]; other site
467705004245	putative shikimate binding site; other site
467705004246	3-phosphoshikimate 1-carboxyvinyltransferase; Provisional; Region: PRK02427
467705004247	EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556
467705004248	hinge; other site
467705004249	active site
467705004250	L-2-hydroxyisocapronate dehydrogenases and some bacterial L-lactate dehydrogenases; Region: HicDH_like; cd05291
467705004251	tetramer (dimer of dimers) interface [polypeptide binding]; other site
467705004252	L-lactate dehydrogenase; Region: L-LDH-NAD; TIGR01771
467705004253	NAD binding site [chemical binding]; other site
467705004254	dimer interface [polypeptide binding]; other site
467705004255	substrate binding site [chemical binding]; other site
467705004256	hypothetical protein; Provisional; Region: PRK13676
467705004257	prephenate dehydrogenase; Validated; Region: PRK06545
467705004258	prephenate dehydrogenase; Validated; Region: PRK08507
467705004259	C-terminal ACT domain of the monofunctional, NAD dependent, prephenate dehydrogenase (PDH); Region: ACT_PDH-BS; cd04909
467705004260	Chorismate synthase [Amino acid transport and metabolism]; Region: AroC; COG0082
467705004261	Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304
467705004262	Tetramer interface [polypeptide binding]; other site
467705004263	active site
467705004264	FMN-binding site [chemical binding]; other site
467705004265	Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195
467705004266	Iron-containing alcohol dehydrogenase; Region: Fe-ADH; pfam00465
467705004267	active site
467705004268	dimer interface [polypeptide binding]; other site
467705004269	metal binding site [ion binding]; metal-binding site
467705004270	shikimate 5-dehydrogenase; Reviewed; Region: aroE; PRK00258
467705004271	Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501
467705004272	NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065
467705004273	shikimate binding site; other site
467705004274	NAD(P) binding site [chemical binding]; other site
467705004275	3-dehydroquinate dehydratase [Amino acid transport and metabolism]; Region: AroD; COG0710
467705004276	Type I 3-dehydroquinase, (3-dehydroquinate dehydratase or DHQase); Region: DHQase_I; cd00502
467705004277	active site
467705004278	catalytic residue [active]
467705004279	dimer interface [polypeptide binding]; other site
467705004280	PUA domain; Region: PUA; cl00607
467705004281	Predicted SAM-dependent methyltransferases [General function prediction only]; Region: COG1092
467705004282	Middle domain of the SAM-dependent methyltransferase RlmI and related proteins; Region: RlmI_M_like; cd11572
467705004283	putative RNA binding site [nucleotide binding]; other site
467705004284	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
467705004285	Phosphoglycerol transferase and related proteins, alkaline phosphatase superfamily [Cell envelope biogenesis, outer membrane]; Region: MdoB; COG1368
467705004286	Sulfatase; Region: Sulfatase; pfam00884
467705004287	GSG_CRISPR01; CRISPR repeat region, Nmeni subtype
467705004288	Stu0660-like CRISPR/Cas system-associated protein Csn2; Region: Stu0660_Csn2; cd12217
467705004289	tetramer interface [polypeptide binding]; other site
467705004290	putative DNA binding site [nucleotide binding]; other site
467705004291	CRISPR/Cas system-associated protein Cas2; Region: Cas2_I_II_III; cl11442
467705004292	CRISPR/Cas system-associated protein Cas1; Region: Cas1_II; cd09720
467705004293	GSG_CRISPR02; CRISPR repeat region, Nmeni subtype
467705004294	CRISPR/Cas system-associated protein Cas9; Region: Csn1; cd09643
467705004295	CRISPR-associated protein Cas9/Csn1, subtype II/NMEMI; Region: cas_Csn1; TIGR01865
467705004296	50S ribosomal protein L19; Provisional; Region: rplS; PRK05338
467705004297	camphor resistance protein CrcB; Provisional; Region: PRK14229
467705004298	camphor resistance protein CrcB; Provisional; Region: PRK14221
467705004299	hypothetical protein; Provisional; Region: PRK07248
467705004300	cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814; cl03223
467705004301	FeS assembly protein SufB; Region: sufB; TIGR01980
467705004302	Family 41 Carbohydrate-Binding Module from pullulanase-like enzymes; Region: CBM41_pullulanase; cd10315
467705004303	carbohydrate binding site [chemical binding]; other site
467705004304	pullulanase, type I; Region: pulA_typeI; TIGR02104
467705004305	Early set domain associated with the catalytic domain of pullulanase (also called dextrinase and alpha-dextrin endo-1,6-alpha glucosidase); Region: E_set_Pullulanase; cd02860
467705004306	Alpha amylase catalytic domain found in Pullulanase (also called dextrinase; alpha-dextrin endo-1,6-alpha glucosidase), limit dextrinase, and related proteins; Region: AmyAc_Pullulanase_LD-like; cd11341
467705004307	Ca binding site [ion binding]; other site
467705004308	active site
467705004309	catalytic site [active]
467705004310	GDP/GTP exchange factor Sec2p; Region: Sec2p; pfam06428
467705004311	putative lipid kinase; Reviewed; Region: PRK13055
467705004312	Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781
467705004313	Uncharacterized protein conserved in archaea (DUF2193); Region: DUF2193; cl02034
467705004314	NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956
467705004315	NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114
467705004316	nucleotide binding pocket [chemical binding]; other site
467705004317	K-X-D-G motif; other site
467705004318	catalytic site [active]
467705004319	NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120
467705004320	NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119
467705004321	Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027
467705004322	Dimer interface [polypeptide binding]; other site
467705004323	BRCT sequence motif; other site
467705004324	Predicted membrane protein [Function unknown]; Region: COG4708
467705004325	Predicted membrane protein [Function unknown]; Region: COG2246
467705004326	GtrA-like protein; Region: GtrA; pfam04138
467705004327	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
467705004328	Coenzyme A binding pocket [chemical binding]; other site
467705004329	Solo B3/4 domain (OB-fold DNA/RNA-binding) of Phe-aaRS-beta [General function prediction only]; Region: COG3382
467705004330	B3/4 domain; Region: B3_4; pfam03483
467705004331	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
467705004332	MarR family; Region: MarR_2; pfam12802
467705004333	Ribonuclease BN family enzyme [Replication, recombination, and repair]; Region: Rbn; COG1295
467705004334	Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086
467705004335	active site
467705004336	Predicted transcriptional regulator containing CBS domains [Transcription]; Region: COG4109
467705004337	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
467705004338	DNA-binding site [nucleotide binding]; DNA binding site
467705004339	DRTGG domain; Region: DRTGG; pfam07085
467705004340	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with a DRTGG domain upstream. The function of the DRTGG domain, named after its conserved residues, is unknown. CBS is a small domain originally...; Region: CBS_pair_DRTGG_assoc; cd04596
467705004341	The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cd03440
467705004342	active site 2 [active]
467705004343	active site 1 [active]
467705004344	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
467705004345	Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583
467705004346	UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072
467705004347	UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555
467705004348	hinge; other site
467705004349	active site
467705004350	hypothetical protein; Provisional; Region: PRK07329
467705004351	Polymerase and Histidinol Phosphatase domain; Region: PHP; cl17102
467705004352	active site
467705004353	Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in Escherichia coli phosphoribosyl-ATP pyrophosphohydrolase (HisIE or PRATP-PH) and its homologs; Region: NTP-PPase_HisIE_like; cd11534
467705004354	metal binding site [ion binding]; metal-binding site
467705004355	phosphoribosyl-AMP cyclohydrolase; Reviewed; Region: hisI; PRK00051
467705004356	The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731
467705004357	Histidine biosynthesis protein; Region: His_biosynth; pfam00977
467705004358	substrate binding site [chemical binding]; other site
467705004359	glutamase interaction surface [polypeptide binding]; other site
467705004360	HisA.  Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1...; Region: HisA; cd04732
467705004361	phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; Region: TIGR00007
467705004362	catalytic residues [active]
467705004363	imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13141
467705004364	Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748
467705004365	putative active site [active]
467705004366	oxyanion strand; other site
467705004367	catalytic triad [active]
467705004368	Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cd07914
467705004369	putative active site pocket [active]
467705004370	4-fold oligomerization interface [polypeptide binding]; other site
467705004371	metal binding residues [ion binding]; metal-binding site
467705004372	3-fold/trimer interface [polypeptide binding]; other site
467705004373	histidinol dehydrogenase; Region: hisD; TIGR00069
467705004374	Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572
467705004375	NAD binding site [chemical binding]; other site
467705004376	dimerization interface [polypeptide binding]; other site
467705004377	product binding site; other site
467705004378	substrate binding site [chemical binding]; other site
467705004379	zinc binding site [ion binding]; other site
467705004380	catalytic residues [active]
467705004381	ATP phosphoribosyltransferase catalytic subunit; Reviewed; Region: hisG; PRK01686
467705004382	ATP phosphoribosyltransferase [Amino acid transport and metabolism]; Region: HisG; COG0040
467705004383	ATP phosphoribosyltransferase, regulatory subunit; Region: hisZ_biosyn_reg; TIGR00443
467705004384	Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773
467705004385	dimer interface [polypeptide binding]; other site
467705004386	motif 1; other site
467705004387	active site
467705004388	motif 2; other site
467705004389	motif 3; other site
467705004390	Histidinol-phosphate/aromatic aminotransferase and cobyric acid decarboxylase [Amino acid transport and metabolism]; Region: HisC; COG0079
467705004391	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
467705004392	pyridoxal 5'-phosphate binding site [chemical binding]; other site
467705004393	homodimer interface [polypeptide binding]; other site
467705004394	catalytic residue [active]
467705004395	Domain of unknown function (DUF4298); Region: DUF4298; pfam14131
467705004396	helicase-exonuclease AddAB, AddA subunit, Firmicutes type; Region: addA_Gpos; TIGR02785
467705004397	Family description; Region: UvrD_C_2; pfam13538
467705004398	PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705
467705004399	ATP-dependent nuclease subunit B; Region: rexB_recomb; TIGR02774
467705004400	PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705
467705004401	x-prolyl-dipeptidyl aminopeptidase; Provisional; Region: PRK05371
467705004402	X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain; Region: PepX_C; cl08482
467705004403	HAMP domain; Region: HAMP; pfam00672
467705004404	dimerization interface [polypeptide binding]; other site
467705004405	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
467705004406	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
467705004407	dimer interface [polypeptide binding]; other site
467705004408	phosphorylation site [posttranslational modification]
467705004409	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
467705004410	ATP binding site [chemical binding]; other site
467705004411	Mg2+ binding site [ion binding]; other site
467705004412	G-X-G motif; other site
467705004413	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
467705004414	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
467705004415	active site
467705004416	phosphorylation site [posttranslational modification]
467705004417	intermolecular recognition site; other site
467705004418	dimerization interface [polypeptide binding]; other site
467705004419	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
467705004420	DNA binding site [nucleotide binding]
467705004421	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
467705004422	ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577
467705004423	FtsX-like permease family; Region: FtsX; pfam02687
467705004424	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
467705004425	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
467705004426	Walker A/P-loop; other site
467705004427	ATP binding site [chemical binding]; other site
467705004428	Q-loop/lid; other site
467705004429	ABC transporter signature motif; other site
467705004430	Walker B; other site
467705004431	D-loop; other site
467705004432	H-loop/switch region; other site
467705004433	Membrane-fusion protein [Cell envelope biogenesis, outer membrane]; Region: AcrA; COG0845
467705004434	Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404
467705004435	HlyD family secretion protein; Region: HlyD_3; pfam13437
467705004436	Lactonase, 7-bladed beta-propeller; Region: Lactonase; pfam10282
467705004437	Sugar transport-related sRNA regulator N-term; Region: SgrR_N; pfam12793
467705004438	PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria.  Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443
467705004439	CoenzymeA binding site [chemical binding]; other site
467705004440	subunit interaction site [polypeptide binding]; other site
467705004441	PHB binding site; other site
467705004442	enolase; Provisional; Region: eno; PRK00077
467705004443	Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313
467705004444	dimer interface [polypeptide binding]; other site
467705004445	metal binding site [ion binding]; metal-binding site
467705004446	substrate binding pocket [chemical binding]; other site
467705004447	Protein of unknown function (DUF1694); Region: DUF1694; pfam07997
467705004448	Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109
467705004449	Glycerate kinase [Carbohydrate transport and metabolism]; Region: COG1929
467705004450	phosphoserine phosphatase SerB; Region: serB; TIGR00338
467705004451	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
467705004452	motif II; other site
467705004453	Septation ring formation regulator, EzrA; Region: EzrA; pfam06160
467705004454	DNA gyrase subunit B; Validated; Region: gyrB; PRK05644
467705004455	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
467705004456	Mg2+ binding site [ion binding]; other site
467705004457	G-X-G motif; other site
467705004458	TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822
467705004459	anchoring element; other site
467705004460	dimer interface [polypeptide binding]; other site
467705004461	ATP binding site [chemical binding]; other site
467705004462	TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366
467705004463	active site
467705004464	putative metal-binding site [ion binding]; other site
467705004465	DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986
467705004466	Haloacid dehalogenase-like hydrolase; Region: HAD_2; pfam13419
467705004467	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
467705004468	motif II; other site
467705004469	DJ-1 family protein; Region: not_thiJ; TIGR01383
467705004470	Type 1 glutamine amidotransferase (GATase1)-like domain found in Human DJ-1; Region: GATase1_DJ-1; cd03135
467705004471	conserved cys residue [active]
467705004472	Bacterial cell division membrane protein [Cell division and chromosome partitioning]; Region: FtsW; COG0772
467705004473	Predicted membrane protein [Function unknown]; Region: COG2855
467705004474	bifunctional ATP-dependent DNA helicase/DNA polymerase III subunit epsilon; Validated; Region: PRK07246
467705004475	DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127
467705004476	active site
467705004477	catalytic site [active]
467705004478	substrate binding site [chemical binding]; other site
467705004479	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251
467705004480	ATP binding site [chemical binding]; other site
467705004481	Helicase C-terminal domain; Region: Helicase_C_2; pfam13307
467705004482	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
467705004483	Cell division protein [Cell division and chromosome partitioning]; Region: FtsX; COG2177
467705004484	cell division ABC transporter subunit FtsX; Provisional; Region: ftsX; PRK11026
467705004485	Predicted ATPase involved in cell division [Cell division and chromosome partitioning]; Region: FtsE; COG2884
467705004486	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
467705004487	Walker A/P-loop; other site
467705004488	ATP binding site [chemical binding]; other site
467705004489	Q-loop/lid; other site
467705004490	ABC transporter signature motif; other site
467705004491	Walker B; other site
467705004492	D-loop; other site
467705004493	H-loop/switch region; other site
467705004494	peptide chain release factor 2; Validated; Region: prfB; PRK00578
467705004495	This domain is found in peptide chain release factors; Region: PCRF; smart00937
467705004496	RF-1 domain; Region: RF-1; pfam00472
467705004497	putative phosphoesterase; Region: acc_ester; TIGR03729
467705004498	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
467705004499	Integral membrane protein (intg_mem_TP0381); Region: Intg_mem_TP0381; pfam09529
467705004500	Integral membrane protein (intg_mem_TP0381); Region: Intg_mem_TP0381; pfam09529
467705004501	UDP-N-acetylmuramyl pentapeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurF; COG0770
467705004502	Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225
467705004503	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
467705004504	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
467705004505	D-alanyl-alanine synthetase A; Reviewed; Region: ddl; PRK01966
467705004506	D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820
467705004507	D-ala D-ala ligase C-terminus; Region: Dala_Dala_lig_C; pfam07478
467705004508	recombination protein RecR; Reviewed; Region: recR; PRK00076
467705004509	RecR protein; Region: RecR; pfam02132
467705004510	TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR.  RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025
467705004511	putative active site [active]
467705004512	putative metal-binding site [ion binding]; other site
467705004513	tetramer interface [polypeptide binding]; other site
467705004514	Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768
467705004515	Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717
467705004516	Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717
467705004517	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905
467705004518	Predicted RNA-bindining protein (contains S1 and HTH domains) [General function prediction only]; Region: COG2996
467705004519	S1 domain; Region: S1_2; pfam13509
467705004520	Ribosomal protein S1-like RNA-binding domain; Region: S1; smart00316
467705004521	ribosome recycling factor; Reviewed; Region: frr; PRK00083
467705004522	Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation.  Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520
467705004523	hinge region; other site
467705004524	UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254
467705004525	putative nucleotide binding site [chemical binding]; other site
467705004526	uridine monophosphate binding site [chemical binding]; other site
467705004527	homohexameric interface [polypeptide binding]; other site
467705004528	A4GalT_like proteins catalyze the addition of galactose or glucose residues to the lipooligosaccharide (LOS) or lipopolysaccharide (LPS) of the bacterial cell surface; Region: GT8_A4GalT_like; cd04194
467705004529	Glycosyl transferase family 8; Region: Glyco_transf_8; pfam01501
467705004530	Ligand binding site; other site
467705004531	metal-binding site
467705004532	Amino acid permease; Region: AA_permease_2; pfam13520
467705004533	Ribosomal protein L1.  The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA.  In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403
467705004534	mRNA/rRNA interface [nucleotide binding]; other site
467705004535	50S ribosomal protein L11; Validated; Region: rplK; PRK00140
467705004536	Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349
467705004537	23S rRNA interface [nucleotide binding]; other site
467705004538	L7/L12 interface [polypeptide binding]; other site
467705004539	putative thiostrepton binding site; other site
467705004540	L25 interface [polypeptide binding]; other site
467705004541	Protein of unknown function (DUF3397); Region: DUF3397; pfam11877
467705004542	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
467705004543	ATPase, P-type (transporting), HAD superfamily, subfamily IC; Region: ATPase_P-type; TIGR01494
467705004544	Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246
467705004545	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
467705004546	motif II; other site
467705004547	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632
467705004548	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
467705004549	active site
467705004550	metal binding site [ion binding]; metal-binding site
467705004551	Mechanosensitive ion channel inner membrane domain 1; Region: MscS_TM; pfam12794
467705004552	DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674
467705004553	FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580
467705004554	Ftsk gamma domain; Region: Ftsk_gamma; pfam09397
467705004555	Putative stress-responsive transcriptional regulator [Transcription / Signal transduction mechanisms]; Region: PspC; COG1983
467705004556	Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cd02883
467705004557	nudix motif; other site
467705004558	Peptidyl-prolyl cis-trans isomerase (rotamase) - cyclophilin family [Posttranslational modification, protein turnover, chaperones]; Region: PpiB; COG0652
467705004559	active site
467705004560	ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488
467705004561	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
467705004562	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
467705004563	ABC transporter; Region: ABC_tran_2; pfam12848
467705004564	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
467705004565	5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Validated; Region: PRK05584
467705004566	5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Region: MTA/SAH-Nsdase; TIGR01704
467705004567	nudix-type nucleoside diphosphatase, YffH/AdpP family; Region: TIGR00052
467705004568	ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424
467705004569	dimer interface [polypeptide binding]; other site
467705004570	ADP-ribose binding site [chemical binding]; other site
467705004571	active site
467705004572	nudix motif; other site
467705004573	metal binding site [ion binding]; metal-binding site
467705004574	bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase; Provisional; Region: glmU; PRK14354
467705004575	N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540
467705004576	Substrate binding site; other site
467705004577	Mg++ binding site; other site
467705004578	N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353
467705004579	active site
467705004580	substrate binding site [chemical binding]; other site
467705004581	CoA binding site [chemical binding]; other site
467705004582	ASC-1 homology domain, subfamily similar to Enterococcus faecalis Ef3133. The ASCH domain, a small beta-barrel domain found in all three kingdoms of life, resembles the RNA-binding PUA domain and may also interact with RNA. ASCH has been proposed to...; Region: ASCH_Ef3133_like; cd06553
467705004583	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
467705004584	Coenzyme A binding pocket [chemical binding]; other site
467705004585	3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK06550
467705004586	classical (c) SDRs; Region: SDR_c; cd05233
467705004587	NAD(P) binding site [chemical binding]; other site
467705004588	active site
467705004589	Protein of unknown function (DUF2829); Region: DUF2829; pfam11195
467705004590	Protein of unknown function (DUF443); Region: DUF443; pfam04276
467705004591	Acetyltransferase (GNAT) domain; Region: Acetyltransf_8; pfam13523
467705004592	Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673
467705004593	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
467705004594	Coenzyme A binding pocket [chemical binding]; other site
467705004595	amino acid transporter; Region: 2A0306; TIGR00909
467705004596	C-terminus of AA_permease; Region: AA_permease_C; pfam13906
467705004597	FtsX-like permease family; Region: FtsX; pfam02687
467705004598	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
467705004599	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
467705004600	Walker A/P-loop; other site
467705004601	ATP binding site [chemical binding]; other site
467705004602	Q-loop/lid; other site
467705004603	ABC transporter signature motif; other site
467705004604	Walker B; other site
467705004605	D-loop; other site
467705004606	H-loop/switch region; other site
467705004607	YSIRK type signal peptide; Region: YSIRK_signal; pfam04650
467705004608	Beta-galactosidase/beta-glucuronidase [Carbohydrate transport and metabolism]; Region: LacZ; COG3250
467705004609	Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837
467705004610	Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703
467705004611	Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836
467705004612	Bacterial Ig-like domain (group 4); Region: Big_4; pfam07532
467705004613	Bacterial Ig-like domain (group 4); Region: Big_4; pfam07532
467705004614	Bacterial Ig-like domain (group 4); Region: Big_4; pfam07532
467705004615	Bacterial Ig-like domain (group 4); Region: Big_4; pfam07532
467705004616	G5 domain; Region: G5; pfam07501
467705004617	G5 domain; Region: G5; pfam07501
467705004618	Cna protein B-type domain; Region: Cna_B; pfam05738
467705004619	Cna protein B-type domain; Region: Cna_B; pfam05738
467705004620	Cna protein B-type domain; Region: Cna_B; pfam05738
467705004621	Cna protein B-type domain; Region: Cna_B; pfam05738
467705004622	Cna protein B-type domain; Region: Cna_B; pfam05738
467705004623	Cna protein B-type domain; Region: Cna_B; pfam05738
467705004624	Cna protein B-type domain; Region: Cna_B; pfam05738
467705004625	Cna protein B-type domain; Region: Cna_B; pfam05738
467705004626	Cna protein B-type domain; Region: Cna_B; pfam05738
467705004627	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
467705004628	S-adenosylmethionine binding site [chemical binding]; other site
467705004629	NrdI Flavodoxin like; Region: Flavodoxin_NdrI; pfam07972
467705004630	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
467705004631	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
467705004632	Protein of unknown function (DUF3021); Region: DUF3021; pfam11457
467705004633	LytTr DNA-binding domain; Region: LytTR; smart00850
467705004634	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
467705004635	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
467705004636	Walker A/P-loop; other site
467705004637	ATP binding site [chemical binding]; other site
467705004638	Q-loop/lid; other site
467705004639	ABC transporter signature motif; other site
467705004640	Walker B; other site
467705004641	D-loop; other site
467705004642	H-loop/switch region; other site
467705004643	Domain of unknown function (DUF4162); Region: DUF4162; pfam13732
467705004644	FtsX-like permease family; Region: FtsX; pfam02687
467705004645	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
467705004646	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
467705004647	Walker A/P-loop; other site
467705004648	ATP binding site [chemical binding]; other site
467705004649	Q-loop/lid; other site
467705004650	ABC transporter signature motif; other site
467705004651	Walker B; other site
467705004652	D-loop; other site
467705004653	H-loop/switch region; other site
467705004654	TraX protein; Region: TraX; cl05434
467705004655	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
467705004656	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
467705004657	ATP binding site [chemical binding]; other site
467705004658	Mg2+ binding site [ion binding]; other site
467705004659	G-X-G motif; other site
467705004660	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
467705004661	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
467705004662	active site
467705004663	phosphorylation site [posttranslational modification]
467705004664	intermolecular recognition site; other site
467705004665	dimerization interface [polypeptide binding]; other site
467705004666	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
467705004667	DNA binding site [nucleotide binding]
467705004668	Mn2+ and Fe2+ transporters of the NRAMP family [Inorganic ion transport and metabolism]; Region: MntH; COG1914
467705004669	Lipase.  Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is "interfacial activation", the process of...; Region: Lipase; cd00741
467705004670	nucleophilic elbow; other site
467705004671	catalytic triad; other site
467705004672	Ferric reductase like transmembrane component; Region: Ferric_reduct; pfam01794
467705004673	NAD(P) binding domain of  ferredoxin reductase-like proteins catalyze electron transfer between an NAD(P)-binding sub-domain of the alpha/beta class and a discrete (usually N-terminal) domain, which varies in orientation with respect to the NAD(P)...; Region: FNR_like_3; cd06198
467705004674	FAD binding pocket [chemical binding]; other site
467705004675	FAD binding motif [chemical binding]; other site
467705004676	phosphate binding motif [ion binding]; other site
467705004677	beta-alpha-beta structure motif; other site
467705004678	NAD binding pocket [chemical binding]; other site
467705004679	Aldose 1-epimerase, similar to Lactococcus lactis lacX; Region: Aldose_epim_lacX; cd09024
467705004680	active site
467705004681	catalytic residues [active]
467705004682	Protein of unknown function (DUF3884); Region: DUF3884; pfam13024
467705004683	6-phospho-beta-galactosidase; Provisional; Region: PRK13511
467705004684	beta-galactosidase; Region: BGL; TIGR03356
467705004685	Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; cl17295
467705004686	Phosphotransferase system, EIIC; Region: PTS_EIIC; pfam02378
467705004687	PTS_IIB: subunit IIB of enzyme II (EII) is the central energy-coupling domain of the phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In the multienzyme PTS complex, EII is a carbohydrate-specific permease consisting of two cytoplasmic...; Region: PTS_IIB; cl10014
467705004688	active site
467705004689	P-loop; other site
467705004690	phosphorylation site [posttranslational modification]
467705004691	PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_lac; cd00215
467705004692	methionine cluster; other site
467705004693	active site
467705004694	phosphorylation site [posttranslational modification]
467705004695	metal binding site [ion binding]; metal-binding site
467705004696	CAT RNA binding domain; Region: CAT_RBD; smart01061
467705004697	transcriptional antiterminator BglG; Provisional; Region: PRK09772
467705004698	PRD domain; Region: PRD; pfam00874
467705004699	PRD domain; Region: PRD; pfam00874
467705004700	tagatose 1,6-diphosphate aldolase; Reviewed; Region: PRK12399
467705004701	1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164
467705004702	tagatose-6-phosphate kinase; Region: lacC; TIGR01231
467705004703	putative substrate binding site [chemical binding]; other site
467705004704	putative ATP binding site [chemical binding]; other site
467705004705	galactose-6-phosphate isomerase subunit LacB; Reviewed; Region: PRK08622
467705004706	galactose-6-phosphate isomerase subunit LacA; Reviewed; Region: PRK08621
467705004707	Phosphotransferase system, galactitol-specific IIC component [Carbohydrate transport and metabolism]; Region: GatC; COG3775
467705004708	PTS system sugar-specific permease component; Region: EIIC-GAT; pfam03611
467705004709	PTS_IIB_galactitol: subunit IIB of enzyme II (EII) of the galactitol-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS).  In this system, EII is a galactitol-specific permease with two cytoplasmic domains (IIA and IIB) and a...; Region: PTS_IIB_galactitol; cd05566
467705004710	active site
467705004711	P-loop; other site
467705004712	phosphorylation site [posttranslational modification]
467705004713	PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211
467705004714	active site
467705004715	phosphorylation site [posttranslational modification]
467705004716	tagatose 1,6-diphosphate aldolase; Reviewed; Region: PRK12399
467705004717	1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164
467705004718	tagatose-6-phosphate kinase; Region: lacC; TIGR01231
467705004719	putative substrate binding site [chemical binding]; other site
467705004720	putative ATP binding site [chemical binding]; other site
467705004721	galactose-6-phosphate isomerase subunit LacB; Reviewed; Region: PRK08622
467705004722	galactose-6-phosphate isomerase subunit LacA; Reviewed; Region: PRK08621
467705004723	Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349
467705004724	DeoR-like helix-turn-helix domain; Region: HTH_DeoR; pfam08220
467705004725	DeoR C terminal sensor domain; Region: DeoRC; pfam00455
467705004726	methionyl-tRNA synthetase; Reviewed; Region: PRK12267
467705004727	catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814
467705004728	active site
467705004729	HIGH motif; other site
467705004730	KMSKS motif; other site
467705004731	Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957
467705004732	tRNA binding surface [nucleotide binding]; other site
467705004733	anticodon binding site; other site
467705004734	tRNA-binding-domain-containing Escherichia coli methionyl-tRNA synthetase (EcMetRS)-like proteins.  This family includes EcMetRS and Aquifex aeolicus Trbp111 (AaTrbp111). This domain has general tRNA binding properties.  MetRS aminoacylates methionine...; Region: tRNA_bind_EcMetRS_like; cd02800
467705004735	dimer interface [polypeptide binding]; other site
467705004736	putative tRNA-binding site [nucleotide binding]; other site
467705004737	Human Ape1-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: Ape1-like_AP-endo; cd09087
467705004738	active site
467705004739	putative catalytic site [active]
467705004740	DNA binding site [nucleotide binding]
467705004741	putative phosphate binding site [ion binding]; other site
467705004742	metal binding site A [ion binding]; metal-binding site
467705004743	AP binding site [nucleotide binding]; other site
467705004744	metal binding site B [ion binding]; metal-binding site
467705004745	Bleomycin binding protein (BLMA) and similar proteins; BLMA confers bleomycin (Bm) resistance by directly binding to Bm; Region: BLMA_like; cd08349
467705004746	dimer interface [polypeptide binding]; other site
467705004747	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
467705004748	ligand binding site [chemical binding]; other site
467705004749	Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177
467705004750	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056
467705004751	minor groove reading motif; other site
467705004752	helix-hairpin-helix signature motif; other site
467705004753	substrate binding pocket [chemical binding]; other site
467705004754	active site
467705004755	Arsenate Reductase (ArsC) family, unknown subfamily; uncharacterized proteins containing a CXXC motif with similarity to thioredoxin (TRX)-fold arsenic reductases, ArsC. Proteins containing a redox active CXXC motif like TRX and glutaredoxin (GRX)...; Region: ArsC_like; cd03036
467705004756	ArsC family; Region: ArsC; pfam03960
467705004757	putative ArsC-like catalytic residues; other site
467705004758	putative TRX-like catalytic residues [active]
467705004759	Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350
467705004760	6-O-methylguanine DNA methyltransferase, ribonuclease-like domain; Region: Methyltransf_1N; pfam02870
467705004761	The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445
467705004762	DNA binding site [nucleotide binding]
467705004763	active site
467705004764	Predicted methyltransferases [General function prediction only]; Region: COG0313
467705004765	Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648
467705004766	putative SAM binding site [chemical binding]; other site
467705004767	putative homodimer interface [polypeptide binding]; other site
467705004768	DNA replication intiation control protein YabA; Reviewed; Region: PRK13169
467705004769	DNA polymerase III subunit delta'; Validated; Region: PRK07276
467705004770	DNA polymerase III subunit delta'; Validated; Region: PRK08485
467705004771	thymidylate kinase; Validated; Region: tmk; PRK00698
467705004772	Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672
467705004773	TMP-binding site; other site
467705004774	ATP-binding site [chemical binding]; other site
467705004775	Uncharacterized conserved protein [Function unknown]; Region: COG1284
467705004776	Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588
467705004777	Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035
467705004778	F0F1 ATP synthase subunit epsilon; Validated; Region: atpC; PRK00571
467705004779	mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152
467705004780	gamma subunit interface [polypeptide binding]; other site
467705004781	epsilon subunit interface [polypeptide binding]; other site
467705004782	LBP interface [polypeptide binding]; other site
467705004783	F0F1 ATP synthase subunit beta; Validated; Region: PRK09280
467705004784	ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874
467705004785	F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133
467705004786	alpha subunit interaction interface [polypeptide binding]; other site
467705004787	Walker A motif; other site
467705004788	ATP binding site [chemical binding]; other site
467705004789	Walker B motif; other site
467705004790	inhibitor binding site; inhibition site
467705004791	ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306
467705004792	mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151
467705004793	core domain interface [polypeptide binding]; other site
467705004794	delta subunit interface [polypeptide binding]; other site
467705004795	epsilon subunit interface [polypeptide binding]; other site
467705004796	F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281
467705004797	ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874
467705004798	F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132
467705004799	beta subunit interaction interface [polypeptide binding]; other site
467705004800	Walker A motif; other site
467705004801	ATP binding site [chemical binding]; other site
467705004802	Walker B motif; other site
467705004803	ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306
467705004804	F0F1 ATP synthase subunit delta; Validated; Region: PRK05758
467705004805	ATP synthase delta (OSCP) subunit; Region: OSCP; pfam00213
467705004806	F0F1-type ATP synthase, subunit b [Energy production and conversion]; Region: AtpF; COG0711
467705004807	F0F1 ATP synthase subunit B; Validated; Region: PRK05759
467705004808	F0F1 ATP synthase subunit A; Validated; Region: PRK05815
467705004809	F0F1-type ATP synthase, subunit a [Energy production and conversion]; Region: AtpB; COG0356
467705004810	F0F1 ATP synthase subunit C; Provisional; Region: PRK13467
467705004811	Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671
467705004812	PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cd01610
467705004813	active site
467705004814	This is a family of oligosaccharide phosphorylases. It includes yeast and mammalian glycogen phosphorylases, plant starch/glucan phosphorylase, as well as the maltodextrin phosphorylases of bacteria. The members of this family catalyze the breakdown of...; Region: GT1_Glycogen_Phosphorylase; cd04300
467705004815	homodimer interface [polypeptide binding]; other site
467705004816	glycogen/starch/alpha-glucan phosphorylases; Region: P_ylase; TIGR02093
467705004817	active site pocket [active]
467705004818	glycogen synthase; Provisional; Region: glgA; PRK00654
467705004819	This family is most closely related to the GT1 family of glycosyltransferases. Glycogen synthase catalyzes the formation and elongation of the alpha-1,4-glucose backbone using ADP-glucose, the second and key step of glycogen biosynthesis. This family...; Region: GT1_Glycogen_synthase_DULL1_like; cd03791
467705004820	ADP-binding pocket [chemical binding]; other site
467705004821	homodimer interface [polypeptide binding]; other site
467705004822	glucose-1-phosphate adenylyltransferase, GlgD subunit; Region: glgD; TIGR02092
467705004823	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
467705004824	active site
467705004825	Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651
467705004826	dimer interface [polypeptide binding]; other site
467705004827	N-terminal domain interface [polypeptide binding]; other site
467705004828	sulfate 1 binding site; other site
467705004829	glucose-1-phosphate adenylyltransferase; Provisional; Region: glgC; PRK05293
467705004830	ADP-glucose pyrophosphorylase is involved in the biosynthesis of glycogen or starch; Region: ADP_Glucose_PP; cd02508
467705004831	ligand binding site; other site
467705004832	oligomer interface; other site
467705004833	Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651
467705004834	dimer interface [polypeptide binding]; other site
467705004835	N-terminal domain interface [polypeptide binding]; other site
467705004836	glycogen branching enzyme; Provisional; Region: PRK12313
467705004837	N-terminal Early set domain associated with the catalytic domain of prokaryotic glycogen branching enzyme; Region: E_set_GBE_prok_N; cd02855
467705004838	Alpha amylase catalytic domain found in the Glycogen branching enzyme (also called 1,4-alpha-glucan branching enzyme); Region: AmyAc_Glg_BE; cd11322
467705004839	active site
467705004840	catalytic site [active]
467705004841	Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; pfam02806
467705004842	Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism]; Region: PtsA; COG1080
467705004843	PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524
467705004844	PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391
467705004845	PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896
467705004846	Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367
467705004847	dimerization domain swap beta strand [polypeptide binding]; other site
467705004848	regulatory protein interface [polypeptide binding]; other site
467705004849	active site
467705004850	regulatory phosphorylation site [posttranslational modification]; other site
467705004851	NrdH-redoxin (NrdH) family; NrdH is a small monomeric protein with a conserved redox active CXXC motif within a TRX fold, characterized by a glutaredoxin (GRX)-like sequence and TRX-like activity profile. In vitro, it displays protein disulfide reductase...; Region: NrdH; cd02976
467705004852	catalytic residues [active]
467705004853	ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK07306
467705004854	Ribonucleotide reductase N-terminal; Region: RNR_N; pfam08343
467705004855	Class I ribonucleotide reductase; Region: RNR_I; cd01679
467705004856	active site
467705004857	dimer interface [polypeptide binding]; other site
467705004858	catalytic residues [active]
467705004859	effector binding site; other site
467705004860	Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939
467705004861	ribonucleotide-diphosphate reductase subunit beta; Provisional; Region: nrdF2; PRK13966
467705004862	Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049
467705004863	dimer interface [polypeptide binding]; other site
467705004864	putative radical transfer pathway; other site
467705004865	diiron center [ion binding]; other site
467705004866	tyrosyl radical; other site
467705004867	CAAX protease self-immunity; Region: Abi; pfam02517
467705004868	Protein of unknown function (DUF3267); Region: DUF3267; pfam11667
467705004869	Protein of unknown function (DUF3169); Region: DUF3169; pfam11368
467705004870	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
467705004871	non-specific DNA binding site [nucleotide binding]; other site
467705004872	salt bridge; other site
467705004873	sequence-specific DNA binding site [nucleotide binding]; other site
467705004874	acetylornithine aminotransferase; Provisional; Region: PRK04260
467705004875	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
467705004876	inhibitor-cofactor binding pocket; inhibition site
467705004877	pyridoxal 5'-phosphate binding site [chemical binding]; other site
467705004878	catalytic residue [active]
467705004879	AAK_NAGK-like: N-Acetyl-L-glutamate kinase (NAGK)-like . Included in this CD are the Escherichia coli and Pseudomonas aeruginosa type NAGKs which catalyze the phosphorylation of N-acetyl-L-glutamate (NAG) by ATP in the second step of arginine...; Region: AAK_NAGK-like; cd04238
467705004880	nucleotide binding site [chemical binding]; other site
467705004881	N-acetyl-L-glutamate binding site [chemical binding]; other site
467705004882	Ornithine acetyltransferase (OAT) family; also referred to as ArgJ. OAT catalyzes the first and fifth steps in arginine biosynthesis, coupling acetylation of glutamate with deacetylation of N-acetylornithine, which allows recycling of the acetyl group in...; Region: OAT; cd02152
467705004883	heterotetramer interface [polypeptide binding]; other site
467705004884	active site pocket [active]
467705004885	cleavage site
467705004886	N-acetyl-gamma-glutamyl-phosphate reductase; Validated; Region: argC; PRK00436
467705004887	Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859
467705004888	alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252
467705004889	Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673
467705004890	motif 1; other site
467705004891	active site
467705004892	motif 2; other site
467705004893	motif 3; other site
467705004894	Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863
467705004895	DHHA1 domain; Region: DHHA1; pfam02272
467705004896	Tubby C 2; Region: Tub_2; cl02043
467705004897	foldase protein PrsA; Reviewed; Region: prsA; PRK01326
467705004898	SurA N-terminal domain; Region: SurA_N; pfam09312
467705004899	PPIC-type PPIASE domain; Region: Rotamase_2; cl08278
467705004900	Predicted O-methyltransferase [General function prediction only]; Region: COG4122
467705004901	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
467705004902	S-adenosylmethionine binding site [chemical binding]; other site
467705004903	Oligoendopeptidase F [Amino acid transport and metabolism]; Region: COG1164
467705004904	Peptidase family M3B Oligopeptidase F (PepF); Region: M3B_PepF_3; cd09608
467705004905	active site
467705004906	Zn binding site [ion binding]; other site
467705004907	Competence protein CoiA-like family; Region: CoiA; cl11541
467705004908	cellobiose phosphotransferase system IIC component; Reviewed; Region: celD; PRK09592
467705004909	Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455
467705004910	PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_lac; cd00215
467705004911	methionine cluster; other site
467705004912	active site
467705004913	phosphorylation site [posttranslational modification]
467705004914	metal binding site [ion binding]; metal-binding site
467705004915	Transcriptional antiterminator [Transcription]; Region: BglG; COG3711
467705004916	HTH domain; Region: HTH_11; pfam08279
467705004917	Mga helix-turn-helix domain; Region: Mga; pfam05043
467705004918	PRD domain; Region: PRD; pfam00874
467705004919	PRD domain; Region: PRD; pfam00874
467705004920	PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568
467705004921	active site
467705004922	P-loop; other site
467705004923	phosphorylation site [posttranslational modification]
467705004924	Phosphoenolpyruvate-dependent sugar phosphotransferase system, EIIA 2; Region: PTS_EIIA_2; pfam00359
467705004925	active site
467705004926	phosphorylation site [posttranslational modification]
467705004927	cellobiose phosphotransferase system IIB component; Reviewed; Region: celB; PRK09590
467705004928	active site
467705004929	P-loop; other site
467705004930	phosphorylation site [posttranslational modification]
467705004931	Uncharacterized conserved protein [Function unknown]; Region: COG4095
467705004932	6-phospho-beta-glucosidase; Reviewed; Region: celA; PRK09589
467705004933	beta-galactosidase; Region: BGL; TIGR03356
467705004934	oligosaccharide:H+ symporter; Region: 2A0105; TIGR00882
467705004935	Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872
467705004936	D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768
467705004937	Domain of unknown function (DUF1958); Region: DUF1958; pfam09211
467705004938	6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363
467705004939	GlcN6P_deaminase: Glucosamine-6-phosphate (GlcN6P) deaminase subfamily; GlcN6P deaminase catalyzes the reversible conversion of GlcN6P to D-fructose-6-phosphate (Fru6P) and ammonium. The reaction is an aldo-keto isomerization coupled with an amination or...; Region: GlcN6P_deaminase; cd01399
467705004940	active site
467705004941	trimer interface [polypeptide binding]; other site
467705004942	allosteric site; other site
467705004943	active site lid [active]
467705004944	hexamer (dimer of trimers) interface [polypeptide binding]; other site
467705004945	S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Provisional; Region: queA; PRK00147
467705004946	S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Region: queA; TIGR00113
467705004947	Arginine repressor [Transcription]; Region: ArgR; COG1438
467705004948	Arginine repressor, DNA binding domain; Region: Arg_repressor; pfam01316
467705004949	Arginine repressor, C-terminal domain; Region: Arg_repressor_C; pfam02863
467705004950	hypothetical protein; Provisional; Region: PRK07205
467705004951	M20 Peptidase Xaa-His dipeptidase (PepV) degrades hydrophobic dipeptides; Region: M20_PepV; cd03888
467705004952	active site
467705004953	metal binding site [ion binding]; metal-binding site
467705004954	Predicted membrane protein [Function unknown]; Region: COG1288
467705004955	C4-dicarboxylate anaerobic carrier; Region: DcuC; pfam03606
467705004956	carbamate kinase; Reviewed; Region: PRK12686
467705004957	AAK_CK: Carbamate kinase (CK) catalyzes both the ATP-phosphorylation of carbamate and carbamoyl phosphate (CP) utilization with the production of ATP from ADP and CP. Both CK (this CD) and nonhomologous CP synthetase synthesize carbamoyl phosphate, an...; Region: AAK_CK; cd04235
467705004958	putative substrate binding site [chemical binding]; other site
467705004959	nucleotide binding site [chemical binding]; other site
467705004960	nucleotide binding site [chemical binding]; other site
467705004961	homodimer interface [polypeptide binding]; other site
467705004962	ornithine carbamoyltransferase; Validated; Region: PRK02102
467705004963	Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729
467705004964	Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185
467705004965	arginine deiminase; Provisional; Region: PRK01388
467705004966	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
467705004967	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
467705004968	ligand binding site [chemical binding]; other site
467705004969	flexible hinge region; other site
467705004970	helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092
467705004971	non-specific DNA interactions [nucleotide binding]; other site
467705004972	DNA binding site [nucleotide binding]
467705004973	sequence specific DNA binding site [nucleotide binding]; other site
467705004974	putative cAMP binding site [chemical binding]; other site
467705004975	Protein of unknown function (DUF1648); Region: DUF1648; pfam07853
467705004976	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
467705004977	dimerization interface [polypeptide binding]; other site
467705004978	putative DNA binding site [nucleotide binding]; other site
467705004979	putative Zn2+ binding site [ion binding]; other site
467705004980	Putative membrane peptidase family (DUF2324); Region: DUF2324; pfam10086
467705004981	Beta-lactamase enzyme family; Region: Beta-lactamase2; pfam13354
467705004982	Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605
467705004983	Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081
467705004984	Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777
467705004985	DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144
467705004986	DNA polymerase III, delta subunit; Region: holA; TIGR01128
467705004987	Predicted membrane metal-binding protein [General function prediction only]; Region: ComEC; COG0658
467705004988	Domain of unknown function (DUF4131); Region: DUF4131; pfam13567
467705004989	Competence protein; Region: Competence; pfam03772
467705004990	Predicted hydrolase (metallo-beta-lactamase superfamily) [General function prediction only]; Region: ComEC; COG2333
467705004991	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
467705004992	SLBB domain; Region: SLBB; pfam10531
467705004993	comEA protein; Region: comE; TIGR01259
467705004994	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cl14786
467705004995	Protein of unknown function with HXXEE motif; Region: HXXEE; pfam13787
467705004996	1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204
467705004997	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989
467705004998	putative acyl-acceptor binding pocket; other site
467705004999	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474
467705005000	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
467705005001	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
467705005002	motif II; other site
467705005003	Predicted O-methyltransferase [General function prediction only]; Region: COG4123
467705005004	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
467705005005	S-adenosylmethionine binding site [chemical binding]; other site
467705005006	The GIY-YIG domain of uncharacterized protein family UPF0213 related to structure-specific endonuclease SLX1; Region: GIY-YIG_UPF0213; cd10456
467705005007	GIY-YIG motif/motif A; other site
467705005008	putative active site [active]
467705005009	putative metal binding site [ion binding]; other site
467705005010	ATP-dependent RNA helicase SrmB; Provisional; Region: PRK11192
467705005011	DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker  B motif; Region: DEADc; cd00268
467705005012	ATP binding site [chemical binding]; other site
467705005013	Mg++ binding site [ion binding]; other site
467705005014	motif III; other site
467705005015	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
467705005016	nucleotide binding region [chemical binding]; other site
467705005017	ATP-binding site [chemical binding]; other site
467705005018	Isocitrate/isopropylmalate dehydrogenase; Region: Iso_dh; cl00445
467705005019	isocitrate dehydrogenase; Validated; Region: PRK06451
467705005020	Bacillus subtilis (Bs) citrate synthase (CS)-II_like. CS catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the citric acid cycle (TCA or Krebs cycle). 2MCS catalyzes the...; Region: BSuCS-II_like; cd06110
467705005021	dimer interface [polypeptide binding]; other site
467705005022	Citrate synthase; Region: Citrate_synt; pfam00285
467705005023	active site
467705005024	citrylCoA binding site [chemical binding]; other site
467705005025	oxalacetate/citrate binding site [chemical binding]; other site
467705005026	coenzyme A binding site [chemical binding]; other site
467705005027	catalytic triad [active]
467705005028	aconitate hydratase; Validated; Region: PRK09277
467705005029	Aconitase A catalytic domain; Region: AcnA_IRP; cd01586
467705005030	substrate binding site [chemical binding]; other site
467705005031	ligand binding site [chemical binding]; other site
467705005032	Aconitase A swivel domain. This is the major form of the TCA cycle enzyme aconitate hydratase, also known as aconitase and citrate hydro-lyase. It includes bacterial and archaeal aconitase A, and the eukaryotic cytosolic form of aconitase. This group...; Region: AcnA_IRP_Swivel; cd01580
467705005033	substrate binding site [chemical binding]; other site
467705005034	CorA-like Mg2+ transporter protein; Region: CorA; pfam01544
467705005035	uncharacterized bacterial subfamily of the Escherichia coli CorA-Salmonella typhimurium ZntB family; Region: EcCorA_ZntB-like_u2; cd12827
467705005036	Cl binding site [ion binding]; other site
467705005037	oligomer interface [polypeptide binding]; other site
467705005038	CAAX protease self-immunity; Region: Abi; pfam02517
467705005039	peptide chain release factor 3; Provisional; Region: prfC; PRK00741
467705005040	Release Factor 3 (RF3) protein involved in the terminal step of translocation in bacteria; Region: RF3; cd04169
467705005041	G1 box; other site
467705005042	putative GEF interaction site [polypeptide binding]; other site
467705005043	GTP/Mg2+ binding site [chemical binding]; other site
467705005044	Switch I region; other site
467705005045	G2 box; other site
467705005046	G3 box; other site
467705005047	Switch II region; other site
467705005048	G4 box; other site
467705005049	G5 box; other site
467705005050	RF3_II: this subfamily represents the domain II of bacterial Release Factor 3 (RF3). Termination of protein synthesis by the ribosome requires two release factor (RF) classes. The class II RF3 is a GTPase that removes class I RFs (RF1 or RF2) from the...; Region: RF3_II; cd03689
467705005051	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474
467705005052	Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; smart00831
467705005053	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
467705005054	Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246
467705005055	haloacid dehalogenase-like hydrolase; Region: HAD; pfam12710
467705005056	Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689
467705005057	Domain of unknown function (DUF1934); Region: DUF1934; pfam09148
467705005058	HD superfamily phosphohydrolases [General function prediction only]; Region: COG1078
467705005059	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
467705005060	Zn2+ binding site [ion binding]; other site
467705005061	Mg2+ binding site [ion binding]; other site
467705005062	sugar phosphate phosphatase; Provisional; Region: PRK10513
467705005063	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
467705005064	active site
467705005065	motif I; other site
467705005066	motif II; other site
467705005067	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
467705005068	FemAB family; Region: FemAB; pfam02388
467705005069	Acetyltransferase (GNAT) domain; Region: Acetyltransf_6; pfam13480
467705005070	FemAB family; Region: FemAB; pfam02388
467705005071	Acetyltransferase (GNAT) domain; Region: Acetyltransf_6; pfam13480
467705005072	FOG: CBS domain [General function prediction only]; Region: COG0517
467705005073	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in  the acetoin utilization proteins in bacteria. Acetoin is a product of fermentative metabolism in many prokaryotic and eukaryotic microorganisms.  They produce...; Region: CBS_pair_ACT_assoc2; cd04585
467705005074	ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141
467705005075	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410
467705005076	ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224
467705005077	Walker A/P-loop; other site
467705005078	ATP binding site [chemical binding]; other site
467705005079	Q-loop/lid; other site
467705005080	ABC transporter signature motif; other site
467705005081	Walker B; other site
467705005082	D-loop; other site
467705005083	H-loop/switch region; other site
467705005084	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411
467705005085	ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219
467705005086	Walker A/P-loop; other site
467705005087	ATP binding site [chemical binding]; other site
467705005088	Q-loop/lid; other site
467705005089	ABC transporter signature motif; other site
467705005090	Walker B; other site
467705005091	D-loop; other site
467705005092	H-loop/switch region; other site
467705005093	ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177
467705005094	Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581
467705005095	TM-ABC transporter signature motif; other site
467705005096	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
467705005097	Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582
467705005098	TM-ABC transporter signature motif; other site
467705005099	ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683
467705005100	Type I periplasmic ligand-binding domain of uncharacterized ABC (Atpase Binding Cassette)-type active transport systems that are predicted to be involved in uptake of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_ligand_binding_like_12; cd06347
467705005101	putative ligand binding site [chemical binding]; other site
467705005102	hypothetical protein; Provisional; Region: PRK02302
467705005103	Protease subunit of ATP-dependent Clp proteases [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: ClpP; COG0740
467705005104	Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017
467705005105	oligomer interface [polypeptide binding]; other site
467705005106	active site residues [active]
467705005107	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
467705005108	active site
467705005109	magnesium-transporting ATPase MgtA; Provisional; Region: PRK10517
467705005110	Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; pfam00690
467705005111	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
467705005112	Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246
467705005113	haloacid dehalogenase-like hydrolase; Region: HAD; pfam12710
467705005114	Soluble P-type ATPase [General function prediction only]; Region: COG4087
467705005115	Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689
467705005116	Bifunctional PLP-dependent enzyme with beta-cystathionase and maltose regulon repressor activities [Amino acid transport and metabolism]; Region: MalY; COG1168
467705005117	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
467705005118	pyridoxal 5'-phosphate binding site [chemical binding]; other site
467705005119	homodimer interface [polypeptide binding]; other site
467705005120	catalytic residue [active]
467705005121	cystathionine gamma-synthase; Reviewed; Region: PRK07269
467705005122	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
467705005123	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
467705005124	catalytic residue [active]
467705005125	Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244
467705005126	Stage V sporulation protein B, also known as Stage III sporulation protein F, and related proteins; Region: MATE_SpoVB_like; cd13124
467705005127	UDP-N-acetylmuramoylalanyl-D-glutamate--L-lysine ligase; Provisional; Region: PRK14022
467705005128	Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225
467705005129	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
467705005130	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
467705005131	Domain of unknown function (DUF1803); Region: DUF1803; pfam08820
467705005132	Domain of unknown function (DUF1803); Region: DUF1803; pfam08820
467705005133	Orthopoxvirus protein of unknown function (DUF830); Region: DUF830; pfam05708
467705005134	Uncharacterized conserved protein [Function unknown]; Region: COG3589
467705005135	Bacterial protein of unknown function (DUF871); Region: DUF871; pfam05913
467705005136	glycine reductase, selenoprotein B; Region: gly_red_sel_B; TIGR01917
467705005137	Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455
467705005138	cellobiose phosphotransferase system IIC component; Reviewed; Region: celD; PRK09592
467705005139	PTS_IIB_chitobiose_lichenan: subunit IIB of enzyme II (EII) of the N,N-diacetylchitobiose-specific and lichenan-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In these systems, EII is either a lichenan- or an N; Region: PTS_IIB_chitobiose_lichenan; cd05564
467705005140	active site
467705005141	P-loop; other site
467705005142	phosphorylation site [posttranslational modification]
467705005143	PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_lac; cd00215
467705005144	methionine cluster; other site
467705005145	active site
467705005146	phosphorylation site [posttranslational modification]
467705005147	metal binding site [ion binding]; metal-binding site
467705005148	RDD family; Region: RDD; pfam06271
467705005149	Transcriptional antiterminator [Transcription]; Region: BglG; COG3711
467705005150	HTH domain; Region: HTH_11; pfam08279
467705005151	Mga helix-turn-helix domain; Region: Mga; pfam05043
467705005152	PRD domain; Region: PRD; pfam00874
467705005153	PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568
467705005154	active site
467705005155	P-loop; other site
467705005156	phosphorylation site [posttranslational modification]
467705005157	PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211
467705005158	active site
467705005159	phosphorylation site [posttranslational modification]
467705005160	putative manganese-dependent inorganic pyrophosphatase; Provisional; Region: PRK05427
467705005161	DHH family; Region: DHH; pfam01368
467705005162	DHHA2 domain; Region: DHHA2; pfam02833
467705005163	pyruvate formate-lyase 1-activating enzyme; Region: PFLA; TIGR02493
467705005164	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
467705005165	FeS/SAM binding site; other site
467705005166	Cna protein B-type domain; Region: Cna_B; pfam05738
467705005167	streptococcal pilin isopeptide linkage domain; Region: strep_pil_rpt; TIGR03786
467705005168	streptococcal pilin isopeptide linkage domain; Region: strep_pil_rpt; TIGR03786
467705005169	LPXTG-motif cell wall anchor domain; Region: LPXTG_anchor; TIGR01167
467705005170	YhcR_OBF_like: A subfamily of OB-fold domains similar to the OB folds of Bacillus subtilis YhcR. YhcR is a sugar-nonspecific nuclease, which is active in the presence of Ca2+ and Mn2+. It cleaves RNA endonucleolytically, producing 3'-monophosphate...; Region: YhcR_OBF_like; cd04486
467705005171	generic binding surface II; other site
467705005172	generic binding surface I; other site
467705005173	Mycoplasma pulmonis MnuA nuclease-like; Region: MnuA_DNase1-like; cd10283
467705005174	putative active site [active]
467705005175	putative catalytic site [active]
467705005176	putative Mg binding site IVb [ion binding]; other site
467705005177	putative phosphate binding site [ion binding]; other site
467705005178	putative DNA binding site [nucleotide binding]; other site
467705005179	putative Mg binding site IVa [ion binding]; other site
467705005180	alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403
467705005181	Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333
467705005182	Ca binding site [ion binding]; other site
467705005183	active site
467705005184	catalytic site [active]
467705005185	PTS system, trehalose-specific IIBC component; Region: PTS-IIBC-Tre; TIGR01992
467705005186	PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212
467705005187	active site turn [active]
467705005188	phosphorylation site [posttranslational modification]
467705005189	Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263
467705005190	PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_glc; cd00210
467705005191	HPr interaction site; other site
467705005192	glycerol kinase (GK) interaction site [polypeptide binding]; other site
467705005193	active site
467705005194	phosphorylation site [posttranslational modification]
467705005195	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
467705005196	DNA-binding site [nucleotide binding]; DNA binding site
467705005197	trehalose operon repressor, B. subtilis-type; Region: trehalos_R_Bsub; TIGR02404
467705005198	UTRA domain; Region: UTRA; pfam07702
467705005199	Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253
467705005200	Domain of unknown function DUF21; Region: DUF21; pfam01595
467705005201	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590
467705005202	Transporter associated domain; Region: CorC_HlyC; pfam03471
467705005203	Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and...; Region: PEPCK_HprK; cl00270
467705005204	Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and...; Region: PEPCK_HprK; cl00270
467705005205	active site
467705005206	metal-binding site [ion binding]
467705005207	active site
467705005208	nucleotide-binding site [chemical binding]; other site
467705005209	nucleotide-binding site [chemical binding]; other site
467705005210	Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628
467705005211	Domain of unknown function DUF20; Region: UPF0118; pfam01594
467705005212	ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121
467705005213	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
467705005214	Walker A/P-loop; other site
467705005215	ATP binding site [chemical binding]; other site
467705005216	Q-loop/lid; other site
467705005217	ABC transporter signature motif; other site
467705005218	Walker B; other site
467705005219	D-loop; other site
467705005220	H-loop/switch region; other site
467705005221	conserved hypothetical integral membrane protein; Region: TIGR03766
467705005222	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
467705005223	S-adenosylmethionine binding site [chemical binding]; other site
467705005224	Predicted Fe-S oxidoreductase [General function prediction only]; Region: COG1242
467705005225	The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445
467705005226	active site
467705005227	DNA binding site [nucleotide binding]
467705005228	Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671
467705005229	PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392
467705005230	active site
467705005231	Predicted membrane protein [Function unknown]; Region: COG3601
467705005232	Protein of unknown function (DUF3816); Region: DUF3816; pfam12822
467705005233	Predicted rRNA methylase (SpoU class) [Translation, ribosomal structure and biogenesis]; Region: CspR; COG0219
467705005234	potassium transporter peripheral membrane component; Reviewed; Region: trkA; PRK09496
467705005235	TrkA-N domain; Region: TrkA_N; pfam02254
467705005236	TrkA-C domain; Region: TrkA_C; pfam02080
467705005237	TrkA-N domain; Region: TrkA_N; pfam02254
467705005238	TrkA-C domain; Region: TrkA_C; pfam02080
467705005239	Trk-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: TrkG; COG0168
467705005240	potassium uptake protein, TrkH family; Region: 2a38; TIGR00933
467705005241	hypothetical protein; Validated; Region: PRK00041
467705005242	16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187
467705005243	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
467705005244	RNA binding surface [nucleotide binding]; other site
467705005245	Pseudouridine synthases, RsuA subfamily; Region: PseudoU_synth_RsuA_like; cd02870
467705005246	active site
467705005247	segregation and condensation protein B; Reviewed; Region: scpB; PRK00135
467705005248	segregation and condensation protein A; Reviewed; Region: scpA; PRK00104
467705005249	site-specific tyrosine recombinase XerD-like protein; Reviewed; Region: xerD; PRK02436
467705005250	DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182
467705005251	DNA binding site [nucleotide binding]
467705005252	Int/Topo IB signature motif; other site
467705005253	active site
467705005254	catalytic residues [active]
467705005255	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_30; cd04643
467705005256	FOG: CBS domain [General function prediction only]; Region: COG0517
467705005257	Escherichia coli YfcE and related proteins, metallophosphatase domain; Region: MPP_YfcE; cd00841
467705005258	active site
467705005259	metal binding site [ion binding]; metal-binding site
467705005260	homotetramer interface [polypeptide binding]; other site
467705005261	putative deoxyribonucleotide triphosphate pyrophosphatase/unknown domain fusion protein; Reviewed; Region: PRK02491
467705005262	NTPase/HAM1.  This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515
467705005263	active site
467705005264	dimerization interface [polypeptide binding]; other site
467705005265	glutamate racemase; Provisional; Region: PRK00865
467705005266	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3763
467705005267	Diaminopimelate decarboxylase [Amino acid transport and metabolism]; Region: LysA; COG0019
467705005268	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828
467705005269	active site
467705005270	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
467705005271	substrate binding site [chemical binding]; other site
467705005272	catalytic residues [active]
467705005273	dimer interface [polypeptide binding]; other site
467705005274	PTS system mannose-specific transporter subunits IIAB; Provisional; Region: PRK15088
467705005275	PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006
467705005276	active pocket/dimerization site; other site
467705005277	active site
467705005278	phosphorylation site [posttranslational modification]
467705005279	PTS_IIB, PTS system, Mannose/sorbose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_man; cd00001
467705005280	active site
467705005281	phosphorylation site [posttranslational modification]
467705005282	PTS system mannose-specific transporter subunit IIC; Provisional; Region: PRK15065
467705005283	Phosphotransferase system, mannose/fructose/N-acetylgalactosamine-specific component IID [Carbohydrate transport and metabolism]; Region: ManZ; COG3716
467705005284	Domain of unknown function (DUF956); Region: DUF956; pfam06115
467705005285	seryl-tRNA synthetase; Provisional; Region: PRK05431
467705005286	Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403
467705005287	Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770
467705005288	dimer interface [polypeptide binding]; other site
467705005289	active site
467705005290	motif 1; other site
467705005291	motif 2; other site
467705005292	motif 3; other site
467705005293	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
467705005294	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
467705005295	Uncharacterized conserved protein [Function unknown]; Region: COG2128
467705005296	Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627
467705005297	Ring-infected erythrocyte surface antigen; Provisional; Region: PTZ00341
467705005298	acetyl-CoA carboxylase subunit alpha; Provisional; Region: PRK12319
467705005299	acetyl-CoA carboxylase subunit beta; Validated; Region: PRK05654
467705005300	A2L zinc ribbon domain; Region: A2L_zn_ribbon; pfam08792
467705005301	malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682
467705005302	acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591
467705005303	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
467705005304	Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786
467705005305	Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878
467705005306	FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288
467705005307	acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated; Region: PRK06302
467705005308	The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850
467705005309	carboxyltransferase (CT) interaction site; other site
467705005310	biotinylation site [posttranslational modification]; other site
467705005311	3-oxoacyl-(acyl carrier protein) synthase II; Reviewed; Region: PRK07314
467705005312	Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834
467705005313	dimer interface [polypeptide binding]; other site
467705005314	active site
467705005315	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557
467705005316	beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333
467705005317	NAD(P) binding site [chemical binding]; other site
467705005318	homotetramer interface [polypeptide binding]; other site
467705005319	homodimer interface [polypeptide binding]; other site
467705005320	active site
467705005321	(acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331
467705005322	malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128
467705005323	putative enoyl-[acyl-carrier-protein] reductase II; Region: enACPred_II; TIGR03151
467705005324	2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730
467705005325	FMN binding site [chemical binding]; other site
467705005326	substrate binding site [chemical binding]; other site
467705005327	putative catalytic residue [active]
467705005328	acyl carrier protein; Provisional; Region: acpP; PRK00982
467705005329	3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352
467705005330	Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830
467705005331	dimer interface [polypeptide binding]; other site
467705005332	active site
467705005333	CoA binding pocket [chemical binding]; other site
467705005334	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
467705005335	MarR family; Region: MarR_2; pfam12802
467705005336	enoyl-CoA hydratase; Provisional; Region: PRK07260
467705005337	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
467705005338	substrate binding site [chemical binding]; other site
467705005339	oxyanion hole (OAH) forming residues; other site
467705005340	trimer interface [polypeptide binding]; other site
467705005341	aspartate kinase; Reviewed; Region: PRK09034
467705005342	AAK_AKiii-YclM-BS: Amino Acid Kinase Superfamily (AAK), AKiii-YclM-BS; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the lysine plus threonine-sensitive aspartokinase isoenzyme AKIII, a monofunctional class enzyme found in...; Region: AAK_AKiii-YclM-BS; cd04245
467705005343	putative catalytic residues [active]
467705005344	putative nucleotide binding site [chemical binding]; other site
467705005345	putative aspartate binding site [chemical binding]; other site
467705005346	ACT domains located C-terminal to the catalytic domain of the lysine plus threonine-sensitive aspartokinase isoenzyme AKIII; Region: ACT_AKiii-YclM-BS_1; cd04911
467705005347	allosteric regulatory residue; other site
467705005348	ACT domains located C-terminal to the catalytic domain of the lysine plus threonine-sensitive aspartokinase isoenzyme AKIII; Region: ACT_AKiii-YclM-BS_2; cd04916
467705005349	RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937
467705005350	ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124
467705005351	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
467705005352	Walker A/P-loop; other site
467705005353	ATP binding site [chemical binding]; other site
467705005354	Q-loop/lid; other site
467705005355	ABC transporter signature motif; other site
467705005356	Walker B; other site
467705005357	D-loop; other site
467705005358	H-loop/switch region; other site
467705005359	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352
467705005360	ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444
467705005361	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
467705005362	Walker A/P-loop; other site
467705005363	ATP binding site [chemical binding]; other site
467705005364	Q-loop/lid; other site
467705005365	ABC transporter signature motif; other site
467705005366	Walker B; other site
467705005367	D-loop; other site
467705005368	H-loop/switch region; other site
467705005369	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
467705005370	oligopeptide ABC transporter permease OppC; Provisional; Region: PRK15406
467705005371	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
467705005372	dimer interface [polypeptide binding]; other site
467705005373	conserved gate region; other site
467705005374	putative PBP binding loops; other site
467705005375	ABC-ATPase subunit interface; other site
467705005376	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601
467705005377	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
467705005378	putative PBP binding loops; other site
467705005379	dimer interface [polypeptide binding]; other site
467705005380	ABC-ATPase subunit interface; other site
467705005381	ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166
467705005382	The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504
467705005383	peptide binding site [polypeptide binding]; other site
467705005384	ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166
467705005385	The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504
467705005386	peptide binding site [polypeptide binding]; other site
467705005387	ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166
467705005388	The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504
467705005389	peptide binding site [polypeptide binding]; other site
467705005390	ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166
467705005391	The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504
467705005392	peptide binding site [polypeptide binding]; other site
467705005393	D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: DacC; COG1686
467705005394	Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872
467705005395	Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; smart00936
467705005396	cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814; cl03223
467705005397	FeS assembly protein SufB; Region: sufB; TIGR01980
467705005398	NifU homolog involved in Fe-S cluster formation [Energy production and conversion]; Region: IscU; COG0822
467705005399	Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664
467705005400	trimerization site [polypeptide binding]; other site
467705005401	active site
467705005402	Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520
467705005403	Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453
467705005404	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
467705005405	catalytic residue [active]
467705005406	Cysteine desulfurase activator SufB [Posttranslational modification, protein turnover, chaperones]; Region: SufB; COG0719
467705005407	FeS assembly protein SufD; Region: sufD; TIGR01981
467705005408	Cysteine desulfurase activator ATPase [Posttranslational modification, protein turnover, chaperones]; Region: sufC; COG0396
467705005409	ABC-type transport system involved in Fe-S cluster assembly, ATPase component; Region: ABC_FeS_Assembly; cd03217
467705005410	Walker A/P-loop; other site
467705005411	ATP binding site [chemical binding]; other site
467705005412	Q-loop/lid; other site
467705005413	ABC transporter signature motif; other site
467705005414	Walker B; other site
467705005415	D-loop; other site
467705005416	H-loop/switch region; other site
467705005417	UDP-N-acetylmuramyl pentapeptide phosphotransferase/UDP-N- acetylglucosamine-1-phosphate transferase [Cell envelope biogenesis, outer membrane]; Region: Rfe; COG0472
467705005418	This subfamily contains Escherichia coli WecA, Bacillus subtilis TagO and related proteins. WecA is an UDP-N-acetylglucosamine (GlcNAc):undecaprenyl-phosphate (Und-P) GlcNAc-1-phosphate transferase that catalyzes the formation of a phosphodiester bond...; Region: GT_WecA_like; cd06853
467705005419	Mg++ binding site [ion binding]; other site
467705005420	putative catalytic motif [active]
467705005421	substrate binding site [chemical binding]; other site
467705005422	adaptor protein; Provisional; Region: PRK02315
467705005423	undecaprenyl pyrophosphate phosphatase; Reviewed; Region: PRK00281
467705005424	Predicted membrane protein (DUF2207); Region: DUF2207; pfam09972
467705005425	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
467705005426	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
467705005427	substrate binding pocket [chemical binding]; other site
467705005428	membrane-bound complex binding site; other site
467705005429	hinge residues; other site
467705005430	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
467705005431	dimer interface [polypeptide binding]; other site
467705005432	conserved gate region; other site
467705005433	putative PBP binding loops; other site
467705005434	ABC-ATPase subunit interface; other site
467705005435	ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126
467705005436	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
467705005437	Walker A/P-loop; other site
467705005438	ATP binding site [chemical binding]; other site
467705005439	Q-loop/lid; other site
467705005440	ABC transporter signature motif; other site
467705005441	Walker B; other site
467705005442	D-loop; other site
467705005443	H-loop/switch region; other site
467705005444	A subgroup of the band 7 domain of flotillin (reggie) like proteins. This subgroup contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin.  Many of these band 7 domain-containing proteins are lipid raft-associated.  Individual...; Region: Band_7_4; cd03407
467705005445	HflK protein; Region: hflK; TIGR01933
467705005446	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
467705005447	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
467705005448	active site
467705005449	phosphorylation site [posttranslational modification]
467705005450	intermolecular recognition site; other site
467705005451	dimerization interface [polypeptide binding]; other site
467705005452	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
467705005453	DNA binding residues [nucleotide binding]
467705005454	dimerization interface [polypeptide binding]; other site
467705005455	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585
467705005456	Histidine kinase; Region: HisKA_3; pfam07730
467705005457	Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518
467705005458	ATP binding site [chemical binding]; other site
467705005459	Mg2+ binding site [ion binding]; other site
467705005460	G-X-G motif; other site
467705005461	ABC-2 type transporter; Region: ABC2_membrane; cl17235
467705005462	ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842
467705005463	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
467705005464	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
467705005465	Walker A/P-loop; other site
467705005466	ATP binding site [chemical binding]; other site
467705005467	Q-loop/lid; other site
467705005468	ABC transporter signature motif; other site
467705005469	Walker B; other site
467705005470	D-loop; other site
467705005471	H-loop/switch region; other site
467705005472	DAK2 domain fusion protein YloV; Region: YloV; TIGR03599
467705005473	DAK2 domain; Region: Dak2; pfam02734
467705005474	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1302
467705005475	50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359
467705005476	Cell wall-active antibiotics response protein (DUF2154); Region: DUF2154; pfam09922
467705005477	LytTr DNA-binding domain; Region: LytTR; smart00850
467705005478	Sugar efflux transporter for intercellular exchange; Region: MtN3_slv; pfam03083
467705005479	ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG3694
467705005480	ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4587
467705005481	ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4587
467705005482	ABC-2 family transporter protein; Region: ABC2_membrane_6; cl01496
467705005483	ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: COG4586
467705005484	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
467705005485	Walker A/P-loop; other site
467705005486	ATP binding site [chemical binding]; other site
467705005487	Q-loop/lid; other site
467705005488	ABC transporter signature motif; other site
467705005489	Walker B; other site
467705005490	D-loop; other site
467705005491	H-loop/switch region; other site
467705005492	fructose-bisphosphate aldolase; Provisional; Region: PRK09197
467705005493	Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947
467705005494	intersubunit interface [polypeptide binding]; other site
467705005495	active site
467705005496	zinc binding site [ion binding]; other site
467705005497	Na+ binding site [ion binding]; other site
467705005498	GyrI-like small molecule binding domain; Region: GyrI-like; cl01368
467705005499	CTP synthetase; Validated; Region: pyrG; PRK05380
467705005500	CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113
467705005501	Catalytic site [active]
467705005502	active site
467705005503	UTP binding site [chemical binding]; other site
467705005504	Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746
467705005505	active site
467705005506	putative oxyanion hole; other site
467705005507	catalytic triad [active]
467705005508	Phosphomannose isomerase [Carbohydrate transport and metabolism]; Region: ManA; COG1482
467705005509	mannose-6-phosphate isomerase, class I; Region: manA; TIGR00218
467705005510	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
467705005511	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
467705005512	ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254
467705005513	Walker A/P-loop; other site
467705005514	ATP binding site [chemical binding]; other site
467705005515	Q-loop/lid; other site
467705005516	ABC transporter signature motif; other site
467705005517	Walker B; other site
467705005518	D-loop; other site
467705005519	H-loop/switch region; other site
467705005520	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
467705005521	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
467705005522	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
467705005523	Walker A/P-loop; other site
467705005524	ATP binding site [chemical binding]; other site
467705005525	Q-loop/lid; other site
467705005526	ABC transporter signature motif; other site
467705005527	Walker B; other site
467705005528	D-loop; other site
467705005529	H-loop/switch region; other site
467705005530	Winged helix DNA-binding domain; Region: HTH_27; pfam13463
467705005531	Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487
467705005532	active site
467705005533	catalytic residues [active]
467705005534	metal binding site [ion binding]; metal-binding site
467705005535	Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940
467705005536	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012
467705005537	nucleotide binding site [chemical binding]; other site
467705005538	glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331
467705005539	Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans).  The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714
467705005540	glutaminase active site [active]
467705005541	SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008
467705005542	dimer interface [polypeptide binding]; other site
467705005543	active site
467705005544	SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009
467705005545	dimer interface [polypeptide binding]; other site
467705005546	active site
467705005547	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
467705005548	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
467705005549	non-specific DNA binding site [nucleotide binding]; other site
467705005550	salt bridge; other site
467705005551	sequence-specific DNA binding site [nucleotide binding]; other site
467705005552	Beta-glucosidase/6-phospho-beta-glucosidase/beta- galactosidase [Carbohydrate transport and metabolism]; Region: BglB; COG2723
467705005553	beta-galactosidase; Region: BGL; TIGR03356
467705005554	Response regulator containing CheY-like receiver domain and AraC-type DNA-binding domain [Signal transduction mechanisms]; Region: COG4753
467705005555	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
467705005556	active site
467705005557	phosphorylation site [posttranslational modification]
467705005558	intermolecular recognition site; other site
467705005559	dimerization interface [polypeptide binding]; other site
467705005560	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
467705005561	Predicted signal transduction protein with a C-terminal ATPase domain [Signal transduction mechanisms]; Region: COG2972
467705005562	Histidine kinase; Region: His_kinase; pfam06580
467705005563	Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518
467705005564	ATP binding site [chemical binding]; other site
467705005565	Mg2+ binding site [ion binding]; other site
467705005566	G-X-G motif; other site
467705005567	Protein of unknown function, DUF624; Region: DUF624; cl02369
467705005568	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
467705005569	Domain of unknown function (DUF3502); Region: DUF3502; pfam12010
467705005570	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
467705005571	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
467705005572	dimer interface [polypeptide binding]; other site
467705005573	conserved gate region; other site
467705005574	putative PBP binding loops; other site
467705005575	ABC-ATPase subunit interface; other site
467705005576	ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209
467705005577	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
467705005578	putative PBP binding loops; other site
467705005579	ABC-ATPase subunit interface; other site
467705005580	Glycosyl hydrolase family 20 (GH20) catalytic domain of N-acetyl-beta-D-glucosaminidase (GcnA, also known as BhsA) and related proteins. GcnA  is an exoglucosidase which cleaves N-acetyl-beta-D-galactosamine (NAG) and N-acetyl-beta-D-galactosamine...; Region: GH20_GcnA-like; cd06565
467705005581	Glycosyl hydrolase family 20, catalytic domain; Region: Glyco_hydro_20; pfam00728
467705005582	putative active site [active]
467705005583	Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940
467705005584	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012
467705005585	nucleotide binding site [chemical binding]; other site
467705005586	Alpha-mannosidase [Carbohydrate transport and metabolism]; Region: AMS1; COG0383
467705005587	N-terminal catalytic domain of SPGH38, a putative alpha-mannosidase of Streptococcus pyogenes, and its prokaryotic homologs; glycoside hydrolase family 38 (GH38); Region: GH38N_AMII_SpGH38_like; cd10814
467705005588	active site
467705005589	metal binding site [ion binding]; metal-binding site
467705005590	homodimer interface [polypeptide binding]; other site
467705005591	catalytic site [active]
467705005592	Alpha mannosidase, middle domain; Region: Alpha-mann_mid; smart00872
467705005593	Uncharacterized conserved protein [Function unknown]; Region: COG3538
467705005594	Protein of unknown function (DUF1237); Region: DUF1237; pfam06824
467705005595	Putative alpha-1,2-mannosidase [Carbohydrate transport and metabolism]; Region: COG3537
467705005596	Glycosyl hydrolase family 92; Region: Glyco_hydro_92; pfam07971
467705005597	Alpha-L-fucosidase [Carbohydrate transport and metabolism]; Region: COG3669
467705005598	Alpha-L-fucosidase; Region: Alpha_L_fucos; cl12119
467705005599	F5/8 type C domain; Region: F5_F8_type_C; pfam00754
467705005600	Nodulin-21 and CCC1-related protein family; Region: Nodulin-21_like_1; cd02432
467705005601	Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063
467705005602	formaldehyde dehydrogenase (FDH)-like; Region: FDH_like_ADH3; cd08287
467705005603	catalytic Zn binding site [ion binding]; other site
467705005604	NAD(P) binding site [chemical binding]; other site
467705005605	structural Zn binding site [ion binding]; other site
467705005606	LXG domain of WXG superfamily; Region: LXG; pfam04740
467705005607	leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390
467705005608	catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812
467705005609	HIGH motif; other site
467705005610	Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603
467705005611	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
467705005612	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
467705005613	active site
467705005614	KMSKS motif; other site
467705005615	Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958
467705005616	tRNA binding surface [nucleotide binding]; other site
467705005617	Putative protein-S-isoprenylcysteine methyltransferase [Posttranslational modification, protein turnover, chaperones]; Region: STE14; COG2020
467705005618	Glycerol dehydrogenase and related enzymes [Energy production and conversion]; Region: GldA; COG0371
467705005619	Glycerol dehydrogenases (GlyDH) catalyzes oxidation of glycerol to dihydroxyacetone in glycerol dissmilation; Region: GlyDH; cd08170
467705005620	dimer interface [polypeptide binding]; other site
467705005621	active site
467705005622	metal binding site [ion binding]; metal-binding site
467705005623	Transaldolase-like fructose-6-phosphate aldolases (FSA) found in bacteria and archaea; Region: Transaldolase_FSA; cd00956
467705005624	active site
467705005625	intersubunit interactions; other site
467705005626	catalytic residue [active]
467705005627	Pyruvate-formate lyase [Energy production and conversion]; Region: PflD; COG1882
467705005628	Pyruvate formate lyase 2 and related enzymes; Region: PFL2_DhaB_BssA; cd01677
467705005629	dimer interface [polypeptide binding]; other site
467705005630	active site
467705005631	glycine loop; other site
467705005632	Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455
467705005633	cellobiose phosphotransferase system IIC component; Reviewed; Region: celD; PRK09592
467705005634	PTS_IIB_chitobiose_lichenan: subunit IIB of enzyme II (EII) of the N,N-diacetylchitobiose-specific and lichenan-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In these systems, EII is either a lichenan- or an N; Region: PTS_IIB_chitobiose_lichenan; cd05564
467705005635	active site
467705005636	P-loop; other site
467705005637	phosphorylation site [posttranslational modification]
467705005638	PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_lac; cd00215
467705005639	active site
467705005640	methionine cluster; other site
467705005641	phosphorylation site [posttranslational modification]
467705005642	metal binding site [ion binding]; metal-binding site
467705005643	Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription]; Region: DeoR; COG2390
467705005644	helix_turn_helix, cAMP Regulatory protein; Region: HTH_CRP; smart00419
467705005645	Putative sugar-binding domain; Region: Sugar-bind; pfam04198
467705005646	Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349
467705005647	DeoR-like helix-turn-helix domain; Region: HTH_DeoR; cl17531
467705005648	DeoR C terminal sensor domain; Region: DeoRC; pfam00455
467705005649	glycyl-radical enzyme activating protein family; Region: PFLE_PFLC; TIGR02494
467705005650	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
467705005651	FeS/SAM binding site; other site
467705005652	Ion transport protein; Region: Ion_trans; pfam00520
467705005653	Ion channel; Region: Ion_trans_2; pfam07885
467705005654	ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698
467705005655	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
467705005656	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
467705005657	Walker A/P-loop; other site
467705005658	ATP binding site [chemical binding]; other site
467705005659	Q-loop/lid; other site
467705005660	ABC transporter signature motif; other site
467705005661	Walker B; other site
467705005662	D-loop; other site
467705005663	H-loop/switch region; other site
467705005664	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
467705005665	non-specific DNA binding site [nucleotide binding]; other site
467705005666	salt bridge; other site
467705005667	sequence-specific DNA binding site [nucleotide binding]; other site
467705005668	Predicted metalloendopeptidase [Posttranslational modification, protein turnover, chaperones]; Region: PepO; COG3590
467705005669	Peptidase family M13 includes neprilysin, endothelin-converting enzyme I; Region: M13; cd08662
467705005670	active site
467705005671	Zn binding site [ion binding]; other site
467705005672	ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121
467705005673	ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235
467705005674	ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108
467705005675	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
467705005676	ABC-ATPase subunit  interface; other site
467705005677	dimer interface [polypeptide binding]; other site
467705005678	putative PBP binding regions; other site
467705005679	Metal binding protein PsaA.  These proteins have been shown to function as initial receptors in ABC transport of Mn2+ and as surface adhesins in some eubacterial species.  They belong to the TroA superfamily of periplasmic metal binding proteins that...; Region: PsaA; cd01137
467705005680	Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297
467705005681	metal binding site [ion binding]; metal-binding site
467705005682	Peroxiredoxin (PRX) family, Atypical 2-cys PRX subfamily; composed of PRXs containing peroxidatic and resolving cysteines, similar to the homodimeric thiol specific antioxidant (TSA) protein also known as TRX-dependent thiol peroxidase (Tpx). Tpx is a...; Region: PRX_Atyp2cys; cd03014
467705005683	dimer interface [polypeptide binding]; other site
467705005684	catalytic triad [active]
467705005685	peroxidatic and resolving cysteines [active]
467705005686	imidazolonepropionase; Validated; Region: PRK09356
467705005687	Imidazolonepropionase/imidazolone-5-propionate hydrolase (Imidazolone-5PH) catalyzes the third step in the histidine degradation pathway, the hydrolysis of (S)-3-(5-oxo-4,5-dihydro-3H-imidazol-4-yl)propanoate to N-formimidoyl-L-glutamate. In bacteria; Region: Imidazolone-5PH; cd01296
467705005688	active site
467705005689	urocanate hydratase; Provisional; Region: PRK05414
467705005690	Glutamate formiminotransferase [Amino acid transport and metabolism]; Region: COG3643
467705005691	Formiminotransferase domain, N-terminal subdomain; Region: FTCD_N; pfam07837
467705005692	Formiminotransferase domain; Region: FTCD; pfam02971
467705005693	Methenyl tetrahydrofolate cyclohydrolase [Amino acid transport and metabolism]; Region: COG3404
467705005694	formate--tetrahydrofolate ligase; Provisional; Region: PRK13505
467705005695	Formyltetrahydrofolate synthetase (FTHFS) catalyzes the ATP-dependent activation of formate ion via its addition to the N10 position of tetrahydrofolate. FTHFS is a highly expressed key enzyme in both the Wood-Ljungdahl pathway of autotrophic CO2...; Region: FTHFS; cd00477
467705005696	Potassium binding sites [ion binding]; other site
467705005697	Cesium cation binding sites [ion binding]; other site
467705005698	HutD; Region: HutD; cl01532
467705005699	amino acid transporter; Region: 2A0306; TIGR00909
467705005700	Phenylalanine ammonia-lyase (PAL) and histidine ammonia-lyase (HAL); Region: PAL-HAL; cd00332
467705005701	active sites [active]
467705005702	tetramer interface [polypeptide binding]; other site
467705005703	formimidoylglutamase; Provisional; Region: PRK13775
467705005704	Formimidoylglutamase or HutE; Region: Formimidoylglutamase; cd09988
467705005705	putative active site [active]
467705005706	putative metal binding site [ion binding]; other site
467705005707	DNA-binding transcriptional activator of the SARP family [Signal transduction mechanisms]; Region: DnrI; COG3629
467705005708	Predicted ATPase [General function prediction only]; Region: COG3899
467705005709	AAA ATPase domain; Region: AAA_16; pfam13191
467705005710	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
467705005711	binding surface
467705005712	TPR motif; other site
467705005713	Protein of unknown function (DUF3114); Region: DUF3114; pfam11311
467705005714	Mn-dependent transcriptional regulator [Transcription]; Region: TroR; COG1321
467705005715	Iron dependent repressor, N-terminal DNA binding domain; Region: Fe_dep_repress; pfam01325
467705005716	Iron dependent repressor, metal binding and dimerisation domain; Region: Fe_dep_repr_C; pfam02742
467705005717	FeoA domain; Region: FeoA; pfam04023
467705005718	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
467705005719	MarR family; Region: MarR; pfam01047
467705005720	hypothetical protein; Provisional; Region: PRK02268
467705005721	CAAX protease self-immunity; Region: Abi; pfam02517
467705005722	Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403
467705005723	active site
467705005724	NTP binding site [chemical binding]; other site
467705005725	metal binding triad [ion binding]; metal-binding site
467705005726	D-Tyrosyl-tRNAtyr deacylases; a class of tRNA-dependent hydrolases which are capable of hydrolyzing the ester bond of D-Tyrosyl-tRNA reducing the level of cellular D-Tyrosine while recycling the peptidyl-tRNA; found in bacteria and in eukaryotes but not...; Region: Dtyr_deacylase; cd00563
467705005727	putative active site [active]
467705005728	dimerization interface [polypeptide binding]; other site
467705005729	putative tRNAtyr binding site [nucleotide binding]; other site
467705005730	Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317
467705005731	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
467705005732	Zn2+ binding site [ion binding]; other site
467705005733	Mg2+ binding site [ion binding]; other site
467705005734	Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399
467705005735	synthetase active site [active]
467705005736	NTP binding site [chemical binding]; other site
467705005737	metal binding site [ion binding]; metal-binding site
467705005738	TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668
467705005739	ACT  domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876
467705005740	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1385
467705005741	RNA methyltransferase, RsmE family; Region: TIGR00046
467705005742	Ribosomal protein L11 methyltransferase (PrmA); Region: PrmA; pfam06325
467705005743	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
467705005744	S-adenosylmethionine binding site [chemical binding]; other site
467705005745	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
467705005746	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
467705005747	GNAT acetyltransferase 2; Region: GNAT_acetyltr_2; pfam13718
467705005748	Coenzyme A binding pocket [chemical binding]; other site
467705005749	Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_23; cd04682
467705005750	nudix motif; other site
467705005751	Protein of unknown function (DUF3013); Region: DUF3013; pfam11217
467705005752	recombination factor protein RarA; Reviewed; Region: PRK13342
467705005753	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
467705005754	Walker A motif; other site
467705005755	ATP binding site [chemical binding]; other site
467705005756	Walker B motif; other site
467705005757	arginine finger; other site
467705005758	MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002
467705005759	M protein trans-acting positive regulator (MGA) HTH domain; Region: HTH_Mga; pfam08280
467705005760	Mga helix-turn-helix domain; Region: Mga; pfam05043
467705005761	M protein trans-acting positive regulator (MGA) PRD domain; Region: PRD_Mga; pfam08270
467705005762	Transglycosylase associated protein; Region: Transgly_assoc; cl00978
467705005763	Small integral membrane protein [Function unknown]; Region: COG5547
467705005764	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1302
467705005765	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
467705005766	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
467705005767	ATP-binding cassette domain of multidrug resistance protein-like transporters; Region: ABCC_MRP_Like; cd03228
467705005768	Walker A/P-loop; other site
467705005769	ATP binding site [chemical binding]; other site
467705005770	Q-loop/lid; other site
467705005771	ABC transporter signature motif; other site
467705005772	Walker B; other site
467705005773	D-loop; other site
467705005774	H-loop/switch region; other site
467705005775	Domain of unknown function (DUF4274); Region: DUF4274; pfam14096
467705005776	Predicted membrane protein [Function unknown]; Region: COG2261
467705005777	Thermophilic metalloprotease (M29); Region: Peptidase_M29; pfam02073
467705005778	Leucyl aminopeptidase (aminopeptidase T) [Amino acid transport and metabolism]; Region: AmpS; COG2309
467705005779	stage V sporulation protein K; Region: spore_V_K; TIGR02881
467705005780	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
467705005781	Walker A motif; other site
467705005782	ATP binding site [chemical binding]; other site
467705005783	Walker B motif; other site
467705005784	arginine finger; other site
467705005785	stage V sporulation protein K; Region: spore_V_K; TIGR02881
467705005786	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
467705005787	Walker A motif; other site
467705005788	ATP binding site [chemical binding]; other site
467705005789	Walker B motif; other site
467705005790	arginine finger; other site
467705005791	DNA polymerase III PolC; Validated; Region: polC; PRK00448
467705005792	DNA polymerase III polC-type N-terminus; Region: DNA_pol3_alph_N; pfam11490
467705005793	polC_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold nucleic acid binding domain of Bacillus subtilis type C replicative DNA polymerase III alpha subunit (polC). Replication in B. subtilis and Staphylococcus aureus requires two...; Region: polC_OBF; cd04484
467705005794	generic binding surface II; other site
467705005795	generic binding surface I; other site
467705005796	Polymerase and Histidinol Phosphatase domain; Region: PHP; cl17102
467705005797	active site
467705005798	DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127
467705005799	active site
467705005800	catalytic site [active]
467705005801	substrate binding site [chemical binding]; other site
467705005802	Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III at PolC gene; Region: PHP_PolIIIA_POLC; cd07435
467705005803	Pleckstrin homology (PH)-like domains in bacteria (PHb); Region: PH-like_bacteria; cd13225
467705005804	pentamer interface [polypeptide binding]; other site
467705005805	dodecaamer interface [polypeptide binding]; other site
467705005806	prolyl-tRNA synthetase; Provisional; Region: PRK09194
467705005807	Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_prok; cd00779
467705005808	dimer interface [polypeptide binding]; other site
467705005809	motif 1; other site
467705005810	active site
467705005811	motif 2; other site
467705005812	INS is an amino acid-editing domain inserted (INS) into the bacterial class II prolyl-tRNA synthetase (ProRS) however, this CD is not exclusively bacterial. It is also found at the N-terminus of the eukaryotic/archaea-like ProRS's of yeasts and...; Region: ProRS-INS; cd04334
467705005813	putative deacylase active site [active]
467705005814	Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA.   PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268
467705005815	active site
467705005816	motif 3; other site
467705005817	ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding; Region: ProRS_anticodon_short; cd00861
467705005818	anticodon binding site; other site
467705005819	RIP metalloprotease RseP; Region: TIGR00054
467705005820	RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163
467705005821	active site
467705005822	Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020
467705005823	PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989
467705005824	protein binding site [polypeptide binding]; other site
467705005825	RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163
467705005826	putative substrate binding region [chemical binding]; other site
467705005827	CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575
467705005828	Cytidylyltransferase family; Region: CTP_transf_1; pfam01148
467705005829	undecaprenyl pyrophosphate synthase; Provisional; Region: PRK14830
467705005830	Undecaprenyl pyrophosphate synthase [Lipid metabolism]; Region: UppS; COG0020
467705005831	catalytic residue [active]
467705005832	putative FPP diphosphate  binding site; other site
467705005833	putative FPP binding hydrophobic cleft; other site
467705005834	dimer interface [polypeptide binding]; other site
467705005835	putative IPP diphosphate binding site; other site
467705005836	preprotein translocase subunit YajC; Validated; Region: yajC; PRK06531
467705005837	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
467705005838	ATPases associated with a variety of cellular activities; Region: AAA; smart00382
467705005839	Walker A motif; other site
467705005840	ATP binding site [chemical binding]; other site
467705005841	Walker B motif; other site
467705005842	arginine finger; other site
467705005843	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
467705005844	Walker A motif; other site
467705005845	ATP binding site [chemical binding]; other site
467705005846	Walker B motif; other site
467705005847	arginine finger; other site
467705005848	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431
467705005849	PTS system, sucrose-specific IIBC component; Region: PTS-II-BC-sucr; TIGR01996
467705005850	PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212
467705005851	active site turn [active]
467705005852	phosphorylation site [posttranslational modification]
467705005853	Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263
467705005854	PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_glc; cd00210
467705005855	HPr interaction site; other site
467705005856	glycerol kinase (GK) interaction site [polypeptide binding]; other site
467705005857	active site
467705005858	phosphorylation site [posttranslational modification]
467705005859	sucrose-6-phosphate hydrolase; Region: scrB_fam; TIGR01322
467705005860	Glycosyl hydrolase family 32, beta-fructosidases; Region: GH32_B_Fructosidase; cd08996
467705005861	substrate binding [chemical binding]; other site
467705005862	active site
467705005863	Glycosyl hydrolases family 32 C terminal; Region: Glyco_hydro_32C; pfam08244
467705005864	Transcriptional regulators [Transcription]; Region: PurR; COG1609
467705005865	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
467705005866	DNA binding site [nucleotide binding]
467705005867	domain linker motif; other site
467705005868	Ligand binding domain of the lacI-like transcription regulator from a novel metal-reducing bacterium Alkaliphilus Metalliredigens (strain Qymf) and its close homologs; Region: PBP1_Qymf_like; cd06291
467705005869	dimerization interface [polypeptide binding]; other site
467705005870	ligand binding site [chemical binding]; other site
467705005871	sodium binding site [ion binding]; other site
467705005872	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
467705005873	active site
467705005874	motif I; other site
467705005875	motif II; other site
467705005876	transcription antitermination protein NusB; Reviewed; Region: nusB; PRK00202
467705005877	putative RNA binding site [nucleotide binding]; other site
467705005878	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1302
467705005879	elongation factor P; Validated; Region: PRK00529
467705005880	Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207
467705005881	S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470
467705005882	RNA binding site [nucleotide binding]; other site
467705005883	S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794
467705005884	RNA binding site [nucleotide binding]; other site
467705005885	Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006
467705005886	Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321
467705005887	Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092
467705005888	active site
467705005889	excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349
467705005890	ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270
467705005891	ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270
467705005892	ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271
467705005893	Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598
467705005894	uncharacterized bacterial subfamily of the Escherichia coli CorA-Salmonella typhimurium ZntB family; Region: EcCorA_ZntB-like_u2; cd12827
467705005895	Cl binding site [ion binding]; other site
467705005896	oligomer interface [polypeptide binding]; other site
467705005897	Protein of unknown function (DUF1129); Region: DUF1129; pfam06570
467705005898	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
467705005899	Coenzyme A binding pocket [chemical binding]; other site
467705005900	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
467705005901	Protein of unknown function (DUF1648); Region: DUF1648; pfam07853
467705005902	ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555
467705005903	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
467705005904	Walker A/P-loop; other site
467705005905	ATP binding site [chemical binding]; other site
467705005906	Q-loop/lid; other site
467705005907	ABC transporter signature motif; other site
467705005908	Walker B; other site
467705005909	D-loop; other site
467705005910	H-loop/switch region; other site
467705005911	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
467705005912	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
467705005913	30S ribosomal protein S18; Reviewed; Region: rpsR; PRK00391
467705005914	Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629
467705005915	SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496
467705005916	dimer interface [polypeptide binding]; other site
467705005917	ssDNA binding site [nucleotide binding]; other site
467705005918	tetramer (dimer of dimers) interface [polypeptide binding]; other site
467705005919	Spt5 C-terminal nonapeptide repeat binding Spt4; Region: CTD; cl17750
467705005920	30S ribosomal protein S6; Reviewed; Region: rpsF; PRK00453
467705005921	GTP cyclohydrolase I (GTP-CH-I) catalyzes the conversion of GTP into dihydroneopterin triphosphate.  The enzyme product is the precursor of tetrahydrofolate in eubacteria, fungi, and plants and of the folate analogs in methanogenic bacteria.  In...; Region: GTP_cyclohydro1; cd00642
467705005922	homodecamer interface [polypeptide binding]; other site
467705005923	GTP cyclohydrolase I; Provisional; Region: PLN03044
467705005924	active site
467705005925	putative catalytic site residues [active]
467705005926	zinc binding site [ion binding]; other site
467705005927	GTP-CH-I/GFRP interaction surface; other site
467705005928	Protease prsW family; Region: PrsW-protease; pfam13367
467705005929	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1636
467705005930	chaperonin GroEL; Reviewed; Region: groEL; PRK12849
467705005931	GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344
467705005932	ring oligomerisation interface [polypeptide binding]; other site
467705005933	ATP/Mg binding site [chemical binding]; other site
467705005934	stacking interactions; other site
467705005935	hinge regions; other site
467705005936	Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320
467705005937	oligomerisation interface [polypeptide binding]; other site
467705005938	mobile loop; other site
467705005939	roof hairpin; other site
467705005940	ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: PhnK; COG1101
467705005941	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
467705005942	Walker A/P-loop; other site
467705005943	ATP binding site [chemical binding]; other site
467705005944	Q-loop/lid; other site
467705005945	ABC transporter signature motif; other site
467705005946	Walker B; other site
467705005947	D-loop; other site
467705005948	H-loop/switch region; other site
467705005949	Type I periplasmic ligand-binding domain of uncharacterized ABC-type transport systems that are predicted to be involved in the uptake of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_uncharacterized_transporter; cd06325
467705005950	zinc binding site [ion binding]; other site
467705005951	putative ligand binding site [chemical binding]; other site
467705005952	Transmembrane subunit (TM) of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which are involved in the uptake of branched-chain amino acids (AAs), as well as TMs of transporters involved in the uptake of...; Region: TM_PBP1_branched-chain-AA_like; cl00454
467705005953	Transmembrane subunit (TM) of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which are involved in the uptake of branched-chain amino acids (AAs), as well as TMs of transporters involved in the uptake of...; Region: TM_PBP1_branched-chain-AA_like; cd06574
467705005954	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
467705005955	TM-ABC transporter signature motif; other site
467705005956	PTS system mannose/fructose/sorbose family IID component; Region: EIID-AGA; pfam03613
467705005957	Phosphotransferase system, mannose/fructose/N-acetylgalactosamine-specific component IIC [Carbohydrate transport and metabolism]; Region: ManY; COG3715
467705005958	PTS system sorbose subfamily IIB component; Region: PTSIIB_sorb; pfam03830
467705005959	active site
467705005960	phosphorylation site [posttranslational modification]
467705005961	PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cl00025
467705005962	active pocket/dimerization site; other site
467705005963	active site
467705005964	phosphorylation site [posttranslational modification]
467705005965	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
467705005966	Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416
467705005967	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
467705005968	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
467705005969	active site
467705005970	phosphorylation site [posttranslational modification]
467705005971	intermolecular recognition site; other site
467705005972	dimerization interface [polypeptide binding]; other site
467705005973	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
467705005974	DNA binding residues [nucleotide binding]
467705005975	dimerization interface [polypeptide binding]; other site
467705005976	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585
467705005977	Histidine kinase; Region: HisKA_3; pfam07730
467705005978	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
467705005979	ATP binding site [chemical binding]; other site
467705005980	Mg2+ binding site [ion binding]; other site
467705005981	G-X-G motif; other site
467705005982	Periplasmic sugar-binding domain of active transport systems that are members of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_sugar_binding_like; cd01536
467705005983	Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407
467705005984	ligand binding site [chemical binding]; other site
467705005985	Cellulase M and related proteins [Carbohydrate transport and metabolism]; Region: FrvX; COG1363
467705005986	M42 Peptidases, also known as glutamyl aminopeptidase family; Region: M42; cd05638
467705005987	oligomer interface [polypeptide binding]; other site
467705005988	active site
467705005989	metal binding site [ion binding]; metal-binding site
467705005990	TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947
467705005991	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
467705005992	catalytic residues [active]
467705005993	tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain.  PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796
467705005994	putative tRNA-binding site [nucleotide binding]; other site
467705005995	Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629
467705005996	SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496
467705005997	dimer interface [polypeptide binding]; other site
467705005998	ssDNA binding site [nucleotide binding]; other site
467705005999	tetramer (dimer of dimers) interface [polypeptide binding]; other site
467705006000	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4868
467705006001	hypothetical protein; Provisional; Region: PRK13663
467705006002	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
467705006003	non-specific DNA binding site [nucleotide binding]; other site
467705006004	salt bridge; other site
467705006005	sequence-specific DNA binding site [nucleotide binding]; other site
467705006006	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
467705006007	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
467705006008	dimer interface [polypeptide binding]; other site
467705006009	phosphorylation site [posttranslational modification]
467705006010	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
467705006011	ATP binding site [chemical binding]; other site
467705006012	Mg2+ binding site [ion binding]; other site
467705006013	G-X-G motif; other site
467705006014	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
467705006015	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
467705006016	active site
467705006017	phosphorylation site [posttranslational modification]
467705006018	intermolecular recognition site; other site
467705006019	dimerization interface [polypeptide binding]; other site
467705006020	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
467705006021	DNA binding site [nucleotide binding]
467705006022	ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730
467705006023	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
467705006024	gallidermin-class lantibiotic protection ABC transporter, ATP-binding subunit; Region: galliderm_ABC; TIGR03740
467705006025	Walker A/P-loop; other site
467705006026	ATP binding site [chemical binding]; other site
467705006027	Q-loop/lid; other site
467705006028	ABC transporter signature motif; other site
467705006029	Walker B; other site
467705006030	D-loop; other site
467705006031	H-loop/switch region; other site
467705006032	Dihydroneopterin aldolase (DHNA) and 7,8-dihydroneopterin triphosphate epimerase domain (DHNTPE); these enzymes have been designated folB and folX, respectively. Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and...; Region: DHNA_DHNTPE; cd00534
467705006033	homooctamer interface [polypeptide binding]; other site
467705006034	active site
467705006035	7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483
467705006036	catalytic center binding site [active]
467705006037	ATP binding site [chemical binding]; other site
467705006038	Folylpolyglutamate synthase [Coenzyme metabolism]; Region: FolC; COG0285
467705006039	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
467705006040	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
467705006041	DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739
467705006042	dihydropteroate synthase; Region: DHPS; TIGR01496
467705006043	substrate binding pocket [chemical binding]; other site
467705006044	dimer interface [polypeptide binding]; other site
467705006045	inhibitor binding site; inhibition site
467705006046	CAAX protease self-immunity; Region: Abi; pfam02517
467705006047	acetate kinase A/propionate kinase 2; Reviewed; Region: PRK00180
467705006048	propionate/acetate kinase; Provisional; Region: PRK12379
467705006049	Adenine-specific DNA methylase [DNA replication, recombination, and repair]; Region: COG0827
467705006050	Methyltransferase domain; Region: Methyltransf_26; pfam13659
467705006051	Competence protein ComGF [Intracellular trafficking and secretion]; Region: ComGF; COG4940
467705006052	Type II secretory pathway pseudopilin; Region: PulG; pfam11773
467705006053	Competence protein ComGC [Intracellular trafficking and secretion]; Region: ComGC; COG4537
467705006054	Type II secretory pathway, component PulF [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulF; COG1459
467705006055	Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482
467705006056	Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482
467705006057	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
467705006058	Walker A motif; other site
467705006059	ATP binding site [chemical binding]; other site
467705006060	Walker B motif; other site
467705006061	Protein of unknown function (DUF1033); Region: DUF1033; pfam06279
467705006062	DNA-directed RNA polymerase subunit beta'; Provisional; Region: PRK00566
467705006063	RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997
467705006064	RNA polymerase I subunit A N-terminus; Region: RPOLA_N; smart00663
467705006065	RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983
467705006066	RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000
467705006067	Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655
467705006068	Rpb1 (beta') - Rpb6 (omega) interaction site [polypeptide binding]; other site
467705006069	G-loop; other site
467705006070	Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655
467705006071	DNA binding site [nucleotide binding]
467705006072	Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site
467705006073	RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585
467705006074	RNA polymerase Rpb2, domain 2; Region: RNA_pol_Rpb2_2; pfam04561
467705006075	DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405
467705006076	RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653
467705006077	RPB1 interaction site [polypeptide binding]; other site
467705006078	RPB10 interaction site [polypeptide binding]; other site
467705006079	RPB11 interaction site [polypeptide binding]; other site
467705006080	RPB3 interaction site [polypeptide binding]; other site
467705006081	RPB12 interaction site [polypeptide binding]; other site
467705006082	Membrane carboxypeptidase (penicillin-binding protein) [Cell envelope biogenesis, outer membrane]; Region: MrcB; COG0744
467705006083	Transglycosylase; Region: Transgly; pfam00912
467705006084	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760
467705006085	tyrosyl-tRNA synthetase; Validated; Region: PRK05912
467705006086	catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805
467705006087	active site
467705006088	HIGH motif; other site
467705006089	dimer interface [polypeptide binding]; other site
467705006090	KMSKS motif; other site
467705006091	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
467705006092	RNA binding surface [nucleotide binding]; other site
467705006093	23S rRNA methyltransferase A; Provisional; Region: rrmA; PRK11088
467705006094	Putative zinc-finger of transcription factor IIIC complex; Region: zf-TFIIIC; pfam12660
467705006095	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
467705006096	S-adenosylmethionine binding site [chemical binding]; other site
467705006097	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371
467705006098	metal-binding site [ion binding]
467705006099	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217
467705006100	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371
467705006101	metal-binding site [ion binding]
467705006102	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
467705006103	Soluble P-type ATPase [General function prediction only]; Region: COG4087
467705006104	copper transport repressor, CopY/TcrY family; Region: CopY_TcrY; TIGR02698
467705006105	Penicillinase repressor; Region: Pencillinase_R; pfam03965
467705006106	ABC-type metal ion transport system, periplasmic component/surface adhesin [Inorganic ion transport and metabolism]; Region: LraI; COG0803
467705006107	Metal binding protein AcdA.  These proteins have been shown to function in the ABC uptake of Zn2+ and Mn2+ and in competence for genetic transformation and adhesion. The AcdA proteins belong to the TroA superfamily of helical backbone metal receptor...; Region: AdcA; cd01017
467705006108	metal binding site [ion binding]; metal-binding site
467705006109	YodA lipocalin-like domain; Region: YodA; pfam09223
467705006110	ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108
467705006111	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
467705006112	ABC-ATPase subunit  interface; other site
467705006113	dimer interface [polypeptide binding]; other site
467705006114	putative PBP binding regions; other site
467705006115	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
467705006116	ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235
467705006117	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
467705006118	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
467705006119	putative DNA binding site [nucleotide binding]; other site
467705006120	putative Zn2+ binding site [ion binding]; other site
467705006121	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
467705006122	H+ Antiporter protein; Region: 2A0121; TIGR00900
467705006123	putative substrate translocation pore; other site
467705006124	Glutamate-cysteine ligase family 2(GCS2); Region: GCS2; cl00954
467705006125	50S ribosomal protein L17; Validated; Region: rplQ; PRK05591
467705006126	DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182
467705006127	N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928
467705006128	alphaNTD homodimer interface [polypeptide binding]; other site
467705006129	alphaNTD - beta interaction site [polypeptide binding]; other site
467705006130	alphaNTD - beta' interaction site [polypeptide binding]; other site
467705006131	Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118
467705006132	30S ribosomal protein S11; Validated; Region: PRK05309
467705006133	Ribosomal protein S13 [Translation, ribosomal structure and biogenesis]; Region: RpsM; COG0099
467705006134	30S ribosomal protein S13; Region: bact_S13; TIGR03631
467705006135	Ribosomal protein L36; Region: Ribosomal_L36; pfam00444
467705006136	S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451
467705006137	rRNA binding site [nucleotide binding]; other site
467705006138	predicted 30S ribosome binding site; other site
467705006139	adenylate kinase; Reviewed; Region: adk; PRK00279
467705006140	Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428
467705006141	AMP-binding site [chemical binding]; other site
467705006142	ATP-AMP (Ap5A)-binding site [chemical binding]; other site
467705006143	preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204
467705006144	SecY translocase; Region: SecY; pfam00344
467705006145	50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592
467705006146	Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins that...; Region: Ribosomal_L30; cd01658
467705006147	23S rRNA binding site [nucleotide binding]; other site
467705006148	30S ribosomal protein S5; Validated; Region: rpsE; PRK00550
467705006149	Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333
467705006150	Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719
467705006151	Ribosomal L18/L5e:  L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432
467705006152	5S rRNA interface [nucleotide binding]; other site
467705006153	L27 interface [polypeptide binding]; other site
467705006154	23S rRNA interface [nucleotide binding]; other site
467705006155	L5 interface [polypeptide binding]; other site
467705006156	50S ribosomal protein L6; Validated; Region: rplF; PRK05498
467705006157	Ribosomal protein L6; Region: Ribosomal_L6; pfam00347
467705006158	Ribosomal protein L6; Region: Ribosomal_L6; pfam00347
467705006159	30S ribosomal protein S8; Validated; Region: rpsH; PRK00136
467705006160	30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08061
467705006161	50S ribosomal protein L5; Validated; Region: rplE; PRK00010
467705006162	Ribosomal protein L5; Region: Ribosomal_L5; pfam00281
467705006163	ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673
467705006164	50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004
467705006165	KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089
467705006166	RNA binding site [nucleotide binding]; other site
467705006167	50S ribosomal protein L14; Validated; Region: rplN; PRK05483
467705006168	30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610
467705006169	Ribosomal L29 protein/HIP.  L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals.  L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427
467705006170	23S rRNA interface [nucleotide binding]; other site
467705006171	putative translocon interaction site; other site
467705006172	signal recognition particle (SRP54) interaction site; other site
467705006173	L23 interface [polypeptide binding]; other site
467705006174	trigger factor interaction site; other site
467705006175	Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433
467705006176	23S rRNA interface [nucleotide binding]; other site
467705006177	5S rRNA interface [nucleotide binding]; other site
467705006178	putative antibiotic binding site [chemical binding]; other site
467705006179	L25 interface [polypeptide binding]; other site
467705006180	L27 interface [polypeptide binding]; other site
467705006181	30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310
467705006182	K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3  is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel.  The KH...; Region: 30S_S3_KH; cd02412
467705006183	G-X-X-G motif; other site
467705006184	Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189
467705006185	Ribosomal protein L22/L17e.  L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit.  It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336
467705006186	putative translocon binding site; other site
467705006187	protein-rRNA interface [nucleotide binding]; other site
467705006188	30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357
467705006189	50S ribosomal protein L2; Validated; Region: rplB; PRK09374
467705006190	Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181
467705006191	Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947
467705006192	50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738
467705006193	50S ribosomal protein L4; Provisional; Region: rplD; PRK05319
467705006194	50S ribosomal protein L3; Validated; Region: rplC; PRK00001
467705006195	30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596
467705006196	Predicted phosphatases [General function prediction only]; Region: Gph; COG0546
467705006197	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
467705006198	motif II; other site
467705006199	Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788
467705006200	Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108
467705006201	GDP-binding site [chemical binding]; other site
467705006202	ACT binding site; other site
467705006203	IMP binding site; other site
467705006204	bifunctional glutamate--cysteine ligase/glutathione synthetase; Provisional; Region: PRK02471
467705006205	Glutamate-cysteine ligase; Region: Glu_cys_ligase; cl17352
467705006206	ATP-grasp domain; Region: ATP-grasp_4; cl17255
467705006207	Hsp33-like chaperonin; Reviewed; Region: hslO; PRK00114
467705006208	Heat shock protein 33 (Hsp33):  Cytosolic protein that acts as a molecular chaperone under oxidative conditions.  In normal (reducing) cytosolic conditions, four conserved Cys residues are coordinated by a Zn ion. Under oxidative stress (such as heat...; Region: Hsp33; cd00498
467705006209	dimerization interface [polypeptide binding]; other site
467705006210	domain crossover interface; other site
467705006211	redox-dependent activation switch; other site
467705006212	putative TIM-barrel protein, nifR3 family; Region: nifR3_yhdG; TIGR00737
467705006213	Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801
467705006214	FMN binding site [chemical binding]; other site
467705006215	active site
467705006216	catalytic residues [active]
467705006217	substrate binding site [chemical binding]; other site
467705006218	Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cd02883
467705006219	nudix motif; other site
467705006220	nicotinamide mononucleotide transporter PnuC; Region: NMN_trans_PnuC; TIGR01528
467705006221	nicotinamide-nucleotide adenylyltransferase, NadR type; Region: nadR_NMN_Atrans; TIGR01526
467705006222	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
467705006223	active site
467705006224	nucleotide binding site [chemical binding]; other site
467705006225	HIGH motif; other site
467705006226	KMSKS motif; other site
467705006227	Predicted ATPase/kinase involved in NAD metabolism [Coenzyme metabolism]; Region: NadR; COG3172
467705006228	ATP-binding subunits of Clp protease and DnaK/DnaJ chaperones [Posttranslational modification, protein turnover, chaperones]; Region: clpA; COG0542
467705006229	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
467705006230	Walker A motif; other site
467705006231	ATP binding site [chemical binding]; other site
467705006232	Walker B motif; other site
467705006233	arginine finger; other site
467705006234	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
467705006235	Walker A motif; other site
467705006236	ATP binding site [chemical binding]; other site
467705006237	Walker B motif; other site
467705006238	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086
467705006239	Firmicute transcriptional repressor of class III stress genes (CtsR); Region: CtsR; pfam05848
467705006240	elongation factor Ts; Provisional; Region: tsf; PRK09377
467705006241	UBA/TS-N domain; Region: UBA; pfam00627
467705006242	Elongation factor TS; Region: EF_TS; pfam00889
467705006243	Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425
467705006244	rRNA interaction site [nucleotide binding]; other site
467705006245	S8 interaction site; other site
467705006246	putative laminin-1 binding site; other site
467705006247	G5 domain; Region: G5; pfam07501
467705006248	G5 domain; Region: G5; pfam07501
467705006249	G5 domain; Region: G5; pfam07501
467705006250	G5 domain; Region: G5; pfam07501
467705006251	G5 domain; Region: G5; pfam07501
467705006252	G5 domain; Region: G5; pfam07501
467705006253	G5 domain; Region: G5; pfam07501
467705006254	LPXTG-motif cell wall anchor domain; Region: LPXTG_anchor; TIGR01167
467705006255	fimbrial isopeptide formation D2 domain; Region: RrgB_K2N_iso_D2; TIGR04226
467705006256	fimbrial isopeptide formation D2 domain; Region: RrgB_K2N_iso_D2; TIGR04226
467705006257	fimbrial isopeptide formation D2 domain; Region: RrgB_K2N_iso_D2; TIGR04226
467705006258	fimbrial isopeptide formation D2 domain; Region: RrgB_K2N_iso_D2; TIGR04226
467705006259	fimbrial isopeptide formation D2 domain; Region: RrgB_K2N_iso_D2; TIGR04226
467705006260	fimbrial isopeptide formation D2 domain; Region: RrgB_K2N_iso_D2; TIGR04226
467705006261	fimbrial isopeptide formation D2 domain; Region: RrgB_K2N_iso_D2; TIGR04226
467705006262	fimbrial isopeptide formation D2 domain; Region: RrgB_K2N_iso_D2; TIGR04226
467705006263	fimbrial isopeptide formation D2 domain; Region: RrgB_K2N_iso_D2; TIGR04226
467705006264	fimbrial isopeptide formation D2 domain; Region: RrgB_K2N_iso_D2; TIGR04226
467705006265	fimbrial isopeptide formation D2 domain; Region: RrgB_K2N_iso_D2; TIGR04226
467705006266	fimbrial isopeptide formation D2 domain; Region: RrgB_K2N_iso_D2; TIGR04226
467705006267	fimbrial isopeptide formation D2 domain; Region: RrgB_K2N_iso_D2; TIGR04226
467705006268	fimbrial isopeptide formation D2 domain; Region: RrgB_K2N_iso_D2; TIGR04226
467705006269	fimbrial isopeptide formation D2 domain; Region: RrgB_K2N_iso_D2; TIGR04226
467705006270	fimbrial isopeptide formation D2 domain; Region: RrgB_K2N_iso_D2; TIGR04226
467705006271	fimbrial isopeptide formation D2 domain; Region: RrgB_K2N_iso_D2; TIGR04226
467705006272	TlpA-like family; composed of  TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966
467705006273	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
467705006274	catalytic residues [active]
467705006275	transcription antitermination protein NusG; Validated; Region: nusG; PRK05609
467705006276	Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891
467705006277	putative homodimer interface [polypeptide binding]; other site
467705006278	NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091
467705006279	heterodimer interface [polypeptide binding]; other site
467705006280	homodimer interface [polypeptide binding]; other site
467705006281	preprotein translocase subunit SecE; Reviewed; Region: secE; PRK07597
467705006282	Predicted metalloprotease [General function prediction only]; Region: COG2321
467705006283	Putative neutral zinc metallopeptidase; Region: Zn_peptidase; pfam04228
467705006284	Transglycosylase; Region: Transgly; pfam00912
467705006285	penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074
467705006286	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905
467705006287	Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564
467705006288	Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869
467705006289	active site
467705006290	Predicted O-acyltransferase [General function prediction only]; Region: COG3274
467705006291	Acyltransferase family; Region: Acyl_transf_3; pfam01757
467705006292	AtlA is an autolysin found in Gram-positive lactic acid bacteria that degrades bacterial cell walls by catalyzing the hydrolysis of 1,4-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues. This family includes the AtlA and Aml...; Region: GH25_AtlA-like; cd06522
467705006293	Glycosyl hydrolases family 25; Region: Glyco_hydro_25; pfam01183
467705006294	active site
467705006295	GBS Bsp-like repeat; Region: GBS_Bsp-like; pfam08481
467705006296	GBS Bsp-like repeat; Region: GBS_Bsp-like; pfam08481
467705006297	GBS Bsp-like repeat; Region: GBS_Bsp-like; pfam08481
467705006298	GBS Bsp-like repeat; Region: GBS_Bsp-like; pfam08481
467705006299	GBS Bsp-like repeat; Region: GBS_Bsp-like; pfam08481
467705006300	GBS Bsp-like repeat; Region: GBS_Bsp-like; pfam08481
467705006301	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
467705006302	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
467705006303	NAD(P) binding site [chemical binding]; other site
467705006304	active site
467705006305	CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516
467705006306	substrate binding site; other site
467705006307	dimer interface; other site
467705006308	LicD family; Region: LicD; pfam04991
467705006309	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
467705006310	Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_d; cd04196
467705006311	Probable Catalytic site; other site
467705006312	Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641
467705006313	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
467705006314	active site
467705006315	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
467705006316	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
467705006317	NAD(P) binding site [chemical binding]; other site
467705006318	active site
467705006319	Bacterial sugar transferase; Region: Bac_transf; pfam02397
467705006320	Predicted nucleoside-diphosphate sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG1086
467705006321	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
467705006322	UDP-Glcnac (UDP-linked N-acetylglucosamine) inverting 4,6-dehydratase, extended (e) SDRs; Region: UDP_invert_4-6DH_SDR_e; cd05237
467705006323	NAD(P) binding site [chemical binding]; other site
467705006324	homodimer interface [polypeptide binding]; other site
467705006325	substrate binding site [chemical binding]; other site
467705006326	active site
467705006327	capsular exopolysaccharide family; Region: eps_fam; TIGR01007
467705006328	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
467705006329	polysaccharide export protein, MPA1 family, Gram-positive type; Region: polys_exp_MPA1; TIGR01006
467705006330	Capsular polysaccharide biosynthesis protein [Cell envelope biogenesis, outer membrane]; Region: COG3944
467705006331	Capsular polysaccharide biosynthesis protein [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: CapC; COG4464
467705006332	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
467705006333	DNA polymerase processivity factor; Region: DNA_PPF; pfam02916
467705006334	Cell envelope-related transcriptional attenuator domain; Region: LytR_cpsA_psr; pfam03816
467705006335	anaerobic ribonucleoside-triphosphate reductase activating protein; Region: NrdG; TIGR02491
467705006336	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
467705006337	FeS/SAM binding site; other site
467705006338	Predicted acetyltransferase [General function prediction only]; Region: COG3981
467705006339	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
467705006340	Predicted acetyltransferase [General function prediction only]; Region: COG3981
467705006341	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
467705006342	anaerobic ribonucleoside triphosphate reductase; Provisional; Region: PRK09263
467705006343	ATP cone domain; Region: ATP-cone; pfam03477
467705006344	Class III ribonucleotide reductase; Region: RNR_III; cd01675
467705006345	effector binding site; other site
467705006346	active site
467705006347	Zn binding site [ion binding]; other site
467705006348	glycine loop; other site
467705006349	cardiolipin synthase; Region: bac_cardiolipin; TIGR04265
467705006350	Phospholipase_D-nuclease N-terminal; Region: PLDc_N; pfam13396
467705006351	Putative catalytic domain, repeat 1, of Streptococcus mutans uncharacterized protein SMU_988 and similar proteins; Region: PLDc_SMU_988_like_1; cd09154
467705006352	putative active site [active]
467705006353	catalytic site [active]
467705006354	Putative catalytic domain, repeat 2, of Streptococcus mutans uncharacterized protein SMU_988 and similar proteins; Region: PLDc_SMU_988_like_2; cd09160
467705006355	putative active site [active]
467705006356	catalytic site [active]
467705006357	Bacterial lipoprotein; Region: DUF3642; pfam12182
467705006358	folylpolyglutamate synthase/dihydrofolate synthase; Region: folC; TIGR01499
467705006359	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
467705006360	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
467705006361	hypothetical protein; Provisional; Region: PRK13678
467705006362	Holliday junction resolvase-like protein; Reviewed; Region: PRK00109
467705006363	hypothetical protein; Provisional; Region: PRK05473
467705006364	Arsenate Reductase (ArsC) family, Spx subfamily; Spx is a unique RNA polymerase (RNAP)-binding protein present in bacilli and some mollicutes. It inhibits transcription by binding to the C-terminal domain of the alpha subunit of RNAP, disrupting complex...; Region: ArsC_Spx; cd03032
467705006365	ArsC family; Region: ArsC; pfam03960
467705006366	putative catalytic residues [active]
467705006367	thiol/disulfide switch; other site
467705006368	recombinase A; Provisional; Region: recA; PRK09354
467705006369	RecA is a  bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response.  RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983
467705006370	hexamer interface [polypeptide binding]; other site
467705006371	Walker A motif; other site
467705006372	ATP binding site [chemical binding]; other site
467705006373	Walker B motif; other site
467705006374	competence damage-inducible protein A; Provisional; Region: PRK00549
467705006375	Competence-damaged protein. CinA is the first gene in the competence- inducible (cin) operon and is thought to be specifically required at some stage in the process of transformation. This domain is closely related to a domain, found in a variety of...; Region: cinA; cd00885
467705006376	putative MPT binding site; other site
467705006377	Uncharacterized protein (competence- and mitomycin-induced) [General function prediction only]; Region: CinA; COG1546
467705006378	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
467705006379	non-specific DNA binding site [nucleotide binding]; other site
467705006380	salt bridge; other site
467705006381	sequence-specific DNA binding site [nucleotide binding]; other site
467705006382	CAAX protease self-immunity; Region: Abi; pfam02517
467705006383	Methyladenine glycosylase; Region: Adenine_glyco; pfam03352
467705006384	Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116
467705006385	RuvA N terminal domain; Region: RuvA_N; pfam01330
467705006386	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
467705006387	non-specific DNA binding site [nucleotide binding]; other site
467705006388	salt bridge; other site
467705006389	sequence-specific DNA binding site [nucleotide binding]; other site
467705006390	RDD family; Region: RDD; pfam06271
467705006391	DNA mismatch repair protein; Reviewed; Region: mutL; PRK00095
467705006392	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
467705006393	ATP binding site [chemical binding]; other site
467705006394	Mg2+ binding site [ion binding]; other site
467705006395	G-X-G motif; other site
467705006396	MutL_Trans: transducer domain, having a ribosomal S5 domain 2-like fold, conserved in the C-terminal domain of DNA mismatch repair (MutL/MLH1/PMS2) family. This transducer domain is homologous to the second domain of the DNA gyrase B subunit, which is...; Region: MutL_Trans; cd00782
467705006397	ATP binding site [chemical binding]; other site
467705006398	MutL C terminal dimerisation domain; Region: MutL_C; pfam08676
467705006399	Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279
467705006400	LytTr DNA-binding domain; Region: LytTR; smart00850
467705006401	Protein of unknown function (DUF3021); Region: DUF3021; pfam11457
467705006402	DNA mismatch repair protein MutS; Provisional; Region: PRK05399
467705006403	MutS domain I; Region: MutS_I; pfam01624
467705006404	MutS domain II; Region: MutS_II; pfam05188
467705006405	MutS domain III; Region: MutS_III; pfam05192
467705006406	ATP-binding cassette domain of MutS1 homolog; Region: ABC_MutS1; cd03284
467705006407	Walker A/P-loop; other site
467705006408	ATP binding site [chemical binding]; other site
467705006409	Q-loop/lid; other site
467705006410	ABC transporter signature motif; other site
467705006411	Walker B; other site
467705006412	D-loop; other site
467705006413	H-loop/switch region; other site
467705006414	Arginine repressor, DNA binding domain; Region: Arg_repressor; pfam01316
467705006415	arginine repressor; Region: argR_whole; TIGR01529
467705006416	Arginine repressor, C-terminal domain; Region: Arg_repressor_C; pfam02863
467705006417	arginyl-tRNA synthetase; Reviewed; Region: PRK12451
467705006418	Arginyl tRNA synthetase N terminal dom; Region: Arg_tRNA_synt_N; smart01016
467705006419	catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671
467705006420	active site
467705006421	HIGH motif; other site
467705006422	KMSK motif region; other site
467705006423	Anticodon-binding domain of arginyl tRNA synthetases; Region: Anticodon_Ia_Arg; cd07956
467705006424	tRNA binding surface [nucleotide binding]; other site
467705006425	anticodon binding site; other site
467705006426	Uncharacterized conserved protein [Function unknown]; Region: COG1284
467705006427	Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588
467705006428	Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588
467705006429	Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035
467705006430	aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476
467705006431	EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317
467705006432	dimer interface [polypeptide binding]; other site
467705006433	anticodon binding site; other site
467705006434	Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777
467705006435	homodimer interface [polypeptide binding]; other site
467705006436	motif 1; other site
467705006437	active site
467705006438	motif 2; other site
467705006439	GAD domain; Region: GAD; pfam02938
467705006440	Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777
467705006441	motif 3; other site
467705006442	histidyl-tRNA synthetase; Reviewed; Region: hisS; PRK00037
467705006443	Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773
467705006444	dimer interface [polypeptide binding]; other site
467705006445	motif 1; other site
467705006446	active site
467705006447	motif 2; other site
467705006448	motif 3; other site
467705006449	HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859
467705006450	anticodon binding site; other site
467705006451	Predicted metal-sulfur cluster biosynthetic enzyme [General function prediction only]; Region: PaaD; COG2151
467705006452	6-phosphogluconate dehydratase; Region: edd; TIGR01196
467705006453	dihydroxy-acid dehydratase; Provisional; Region: PRK00911
467705006454	50S ribosomal protein L32; Validated; Region: rpmF; PRK01110
467705006455	50S ribosomal protein L33; Validated; Region: rpmG; PRK00595
467705006456	ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4587
467705006457	ABC-2 family transporter protein; Region: ABC2_membrane_6; cl01496
467705006458	ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4587
467705006459	ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: COG4586
467705006460	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
467705006461	Walker A/P-loop; other site
467705006462	ATP binding site [chemical binding]; other site
467705006463	Q-loop/lid; other site
467705006464	ABC transporter signature motif; other site
467705006465	Walker B; other site
467705006466	D-loop; other site
467705006467	H-loop/switch region; other site
467705006468	FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580
467705006469	Plasmid replication protein; Region: Rep_2; pfam01719
467705006470	phiLC3 phage and phage-related integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes various bacterial (mainly gram positive) and phage integrases, including those similar to Lactococcus...; Region: INT_phiLC3_C; cd01189
467705006471	Int/Topo IB signature motif; other site
467705006472	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
467705006473	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
467705006474	Walker A/P-loop; other site
467705006475	ATP binding site [chemical binding]; other site
467705006476	Q-loop/lid; other site
467705006477	ABC transporter signature motif; other site
467705006478	Walker B; other site
467705006479	D-loop; other site
467705006480	H-loop/switch region; other site
467705006481	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
467705006482	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
467705006483	WHG domain; Region: WHG; pfam13305
467705006484	Putative NADPH-quinone reductase (modulator of drug activity B) [General function prediction only]; Region: MdaB; COG2249
467705006485	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
467705006486	adenylosuccinate lyase; Provisional; Region: PRK07492
467705006487	Adenylsuccinate lyase (ASL)_subgroup 1; Region: Adenylsuccinate_lyase_1; cd01360
467705006488	tetramer interface [polypeptide binding]; other site
467705006489	active site
467705006490	Domain of unknown function (DUF4041); Region: DUF4041; pfam13250
467705006491	This entry represents the putative helicase A859L; Region: T5orf172; smart00974
467705006492	phosphoribosylaminoimidazole carboxylase ATPase subunit; Reviewed; Region: PRK06019
467705006493	ATP-grasp domain; Region: ATP-grasp; pfam02222
467705006494	Phosphoribosylcarboxyaminoimidazole (NCAIR) mutase [Nucleotide transport and metabolism]; Region: PurE; COG0041
467705006495	ATP-grasp domain; Region: ATP-grasp_4; cl17255
467705006496	phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885
467705006497	Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844
467705006498	Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Region: GARS_A; pfam01071
467705006499	Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843
467705006500	GBS Bsp-like repeat; Region: GBS_Bsp-like; pfam08481
467705006501	GBS Bsp-like repeat; Region: GBS_Bsp-like; pfam08481
467705006502	GBS Bsp-like repeat; Region: GBS_Bsp-like; pfam08481
467705006503	Surface antigen [General function prediction only]; Region: COG3942
467705006504	CHAP domain; Region: CHAP; cl17642
467705006505	bacteriocin secretion accessory protein; Region: bacteriocin_acc; TIGR01000
467705006506	HlyD family secretion protein; Region: HlyD_3; pfam13437
467705006507	A sub-family of peptidase family C39. Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various...; Region: Peptidase_C39B; cd02418
467705006508	ABC-type bacteriocin transporter; Region: bacteriocin_ABC; TIGR01193
467705006509	putative active site [active]
467705006510	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
467705006511	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
467705006512	Walker A/P-loop; other site
467705006513	ATP binding site [chemical binding]; other site
467705006514	Q-loop/lid; other site
467705006515	ABC transporter signature motif; other site
467705006516	Walker B; other site
467705006517	D-loop; other site
467705006518	H-loop/switch region; other site
467705006519	30S ribosomal protein S4; Validated; Region: rpsD; PRK05327
467705006520	Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163
467705006521	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
467705006522	RNA binding surface [nucleotide binding]; other site
467705006523	ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116
467705006524	ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293
467705006525	Walker A/P-loop; other site
467705006526	ATP binding site [chemical binding]; other site
467705006527	Q-loop/lid; other site
467705006528	ABC transporter signature motif; other site
467705006529	Walker B; other site
467705006530	D-loop; other site
467705006531	H-loop/switch region; other site
467705006532	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cl17432
467705006533	NMT1/THI5 like; Region: NMT1; pfam09084
467705006534	TRAP transporter solute receptor, TAXI family; Region: TRAP_TAXI; TIGR02122
467705006535	ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600
467705006536	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
467705006537	dimer interface [polypeptide binding]; other site
467705006538	conserved gate region; other site
467705006539	putative PBP binding loops; other site
467705006540	ABC-ATPase subunit interface; other site
467705006541	Uncharacterized conserved protein [Function unknown]; Region: COG0011
467705006542	Haloacid dehalogenase-like hydrolase; Region: HAD_2; pfam13419
467705006543	REG-2-like, HAD superfamily (subfamily IA) hydrolase; Region: DREG-2; TIGR02252
467705006544	Sortase B (SrtB) or subfamily-2 sortases are membrane cysteine transpeptidases found in gram-positive bacteria that anchor surface proteins to peptidoglycans of the bacterial cell wall envelope. This involves a transpeptidation reaction in which the...; Region: Sortase_B_2; cd05826
467705006545	active site
467705006546	catalytic site [active]
467705006547	ribose-phosphate pyrophosphokinase; Provisional; Region: PRK02269
467705006548	N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793
467705006549	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
467705006550	active site
467705006551	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3883
467705006552	Septum formation initiator; Region: DivIC; cl17659
467705006553	Surface antigen [General function prediction only]; Region: COG3942
467705006554	CHAP domain; Region: CHAP; pfam05257
467705006555	rod shape-determining protein MreC; Provisional; Region: PRK13922
467705006556	rod shape-determining protein MreC; Region: MreC; pfam04085
467705006557	RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937
467705006558	ATP-dependent Zn proteases [Posttranslational modification, protein turnover, chaperones]; Region: HflB; COG0465
467705006559	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
467705006560	Walker A motif; other site
467705006561	ATP binding site [chemical binding]; other site
467705006562	Walker B motif; other site
467705006563	arginine finger; other site
467705006564	Peptidase family M41; Region: Peptidase_M41; pfam01434
467705006565	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
467705006566	active site
467705006567	tRNA(Ile)-lysidine synthase MesJ [Cell cycle control, cell division, chromosome partitioning]; Region: MesJ; COG0037
467705006568	N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992
467705006569	Ligand Binding Site [chemical binding]; other site
467705006570	TilS substrate C-terminal domain; Region: TilS_C; smart00977
467705006571	Beta-lactamase enzyme family; Region: Beta-lactamase2; pfam13354
467705006572	Septum formation initiator; Region: DivIC; cl17659
467705006573	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
467705006574	RNA binding surface [nucleotide binding]; other site
467705006575	Transcription-repair coupling factor (superfamily II helicase) [DNA replication, recombination, and repair / Transcription]; Region: Mfd; COG1197
467705006576	CarD-like/TRCF domain; Region: CarD_TRCF; smart01058
467705006577	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
467705006578	ATP binding site [chemical binding]; other site
467705006579	putative Mg++ binding site [ion binding]; other site
467705006580	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
467705006581	nucleotide binding region [chemical binding]; other site
467705006582	ATP-binding site [chemical binding]; other site
467705006583	This domain is found in proteins necessary for strand-specific repair in DNA such as TRCF in Escherichia coli; Region: TRCF; smart00982
467705006584	Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462
467705006585	putative active site [active]
467705006586	catalytic residue [active]
467705006587	GTP-binding protein YchF; Reviewed; Region: PRK09601
467705006588	YchF GTPase; Region: YchF; cd01900
467705006589	G1 box; other site
467705006590	GTP/Mg2+ binding site [chemical binding]; other site
467705006591	Switch I region; other site
467705006592	G2 box; other site
467705006593	Switch II region; other site
467705006594	G3 box; other site
467705006595	G4 box; other site
467705006596	G5 box; other site
467705006597	TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867
467705006598	Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279
467705006599	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
467705006600	active site
467705006601	phosphorylation site [posttranslational modification]
467705006602	intermolecular recognition site; other site
467705006603	dimerization interface [polypeptide binding]; other site
467705006604	LytTr DNA-binding domain; Region: LytTR; pfam04397
467705006605	Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518
467705006606	COMC family; Region: ComC; pfam03047
467705006607	rRNA large subunit methyltransferase; Provisional; Region: PRK00103
467705006608	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265
467705006609	Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365
467705006610	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
467705006611	protein binding site [polypeptide binding]; other site
467705006612	ParB/RepB/Spo0J family partition protein; Region: parB_part; TIGR00180
467705006613	ParB-like nuclease domain; Region: ParBc; pfam02195
467705006614	KorB domain; Region: KorB; pfam08535