-- dump date   	20140620_082733
-- class       	Genbank::misc_feature
-- table       	misc_feature_note
-- id	note
862967000001	chromosomal replication initiation protein; Reviewed; Region: dnaA; PRK00149
862967000002	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
862967000003	Walker A motif; other site
862967000004	ATP binding site [chemical binding]; other site
862967000005	Walker B motif; other site
862967000006	arginine finger; other site
862967000007	C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571
862967000008	DnaA box-binding interface [nucleotide binding]; other site
862967000009	DNA polymerase III subunit beta; Validated; Region: PRK05643
862967000010	Beta clamp domain.  The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria.  The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140
862967000011	putative DNA binding surface [nucleotide binding]; other site
862967000012	dimer interface [polypeptide binding]; other site
862967000013	beta-clamp/clamp loader binding surface; other site
862967000014	beta-clamp/translesion DNA polymerase binding surface; other site
862967000015	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4481
862967000016	Protein of unknown function (DUF1307); Region: DUF1307; pfam06998
862967000017	GTP-binding protein YchF; Reviewed; Region: PRK09601
862967000018	YchF GTPase; Region: YchF; cd01900
862967000019	G1 box; other site
862967000020	GTP/Mg2+ binding site [chemical binding]; other site
862967000021	Switch I region; other site
862967000022	G2 box; other site
862967000023	Switch II region; other site
862967000024	G3 box; other site
862967000025	G4 box; other site
862967000026	G5 box; other site
862967000027	TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867
862967000028	Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462
862967000029	putative active site [active]
862967000030	catalytic residue [active]
862967000031	Transcription-repair coupling factor (superfamily II helicase) [DNA replication, recombination, and repair / Transcription]; Region: Mfd; COG1197
862967000032	CarD-like/TRCF domain; Region: CarD_TRCF; smart01058
862967000033	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
862967000034	ATP binding site [chemical binding]; other site
862967000035	putative Mg++ binding site [ion binding]; other site
862967000036	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
862967000037	nucleotide binding region [chemical binding]; other site
862967000038	ATP-binding site [chemical binding]; other site
862967000039	This domain is found in proteins necessary for strand-specific repair in DNA such as TRCF in Escherichia coli; Region: TRCF; smart00982
862967000040	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
862967000041	RNA binding surface [nucleotide binding]; other site
862967000042	Septum formation initiator [Cell division and chromosome partitioning]; Region: COG2919
862967000043	Beta-lactamase class A [Defense mechanisms]; Region: PenP; COG2367
862967000044	Beta-lactamase enzyme family; Region: Beta-lactamase2; pfam13354
862967000045	tRNA(Ile)-lysidine synthase MesJ [Cell cycle control, cell division, chromosome partitioning]; Region: MesJ; COG0037
862967000046	N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992
862967000047	Ligand Binding Site [chemical binding]; other site
862967000048	TilS substrate C-terminal domain; Region: TilS_C; smart00977
862967000049	Pyrimidine operon attenuation protein/uracil phosphoribosyltransferase [Nucleotide transport and metabolism]; Region: PyrR; COG2065
862967000050	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
862967000051	active site
862967000052	ATP-dependent Zn proteases [Posttranslational modification, protein turnover, chaperones]; Region: HflB; COG0465
862967000053	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
862967000054	Walker A motif; other site
862967000055	ATP binding site [chemical binding]; other site
862967000056	Walker B motif; other site
862967000057	arginine finger; other site
862967000058	Peptidase family M41; Region: Peptidase_M41; pfam01434
862967000059	Sialidase, N-terminal domain; Region: Sialidase; pfam02973
862967000060	Sialidases or neuraminidases function to bind and hydrolyze terminal sialic acid residues from various glycoconjugates as well as playing roles in pathogenesis, bacterial nutrition and cellular interactions. They have a six-bladed, beta-propeller fold...; Region: Sialidase; cd00260
862967000061	catalytic site [active]
862967000062	Sialidases or neuraminidases function to bind and hydrolyze terminal sialic acid residues from various glycoconjugates as well as playing roles in pathogenesis, bacterial nutrition and cellular interactions. They have a six-bladed, beta-propeller fold...; Region: Sialidase; cd00260
862967000063	Asp-box motif; other site
862967000064	Asp-box motif; other site
862967000065	catalytic site [active]
862967000066	rod shape-determining protein MreC; Provisional; Region: PRK13922
862967000067	rod shape-determining protein MreC; Region: MreC; pfam04085
862967000068	rod shape-determining protein MreD; Region: MreD; cl01087
862967000069	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3883
862967000070	Homeobox associated leucine zipper; Region: HALZ; cl02577
862967000071	Surface antigen [General function prediction only]; Region: COG3942
862967000072	CHAP domain; Region: CHAP; pfam05257
862967000073	ribose-phosphate pyrophosphokinase; Provisional; Region: PRK02269
862967000074	N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793
862967000075	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
862967000076	active site
862967000077	aromatic amino acid aminotransferase; Validated; Region: PRK07309
862967000078	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
862967000079	pyridoxal 5'-phosphate binding site [chemical binding]; other site
862967000080	homodimer interface [polypeptide binding]; other site
862967000081	catalytic residue [active]
862967000082	DNA repair protein RecO; Region: reco; TIGR00613
862967000083	Recombination protein O N terminal; Region: RecO_N; pfam11967
862967000084	Recombination protein O C terminal; Region: RecO_C; pfam02565
862967000085	putative phosphate acyltransferase; Provisional; Region: PRK05331
862967000086	Phosphopantetheine attachment site; Region: PP-binding; cl09936
862967000087	phosphoribosylaminoimidazole-succinocarboxamide synthase; Reviewed; Region: PRK09362
862967000088	bacterial and archaeal 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_PurC; cd01415
862967000089	ATP binding site [chemical binding]; other site
862967000090	active site
862967000091	substrate binding site [chemical binding]; other site
862967000092	phosphoribosylformylglycinamidine synthase, clade II; Region: FGAM-synthase; TIGR01857
862967000093	AIR (aminoimidazole ribonucleotide) synthase related protein. This family includes Hydrogen expression/formation protein HypE, AIR synthases, FGAM (formylglycinamidine ribonucleotide) synthase and Selenophosphate synthetase (SelD). The N-terminal domain...; Region: PurM-like; cl10019
862967000094	PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203
862967000095	dimerization interface [polypeptide binding]; other site
862967000096	ATP binding site [chemical binding]; other site
862967000097	PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat2; cd02204
862967000098	dimerization interface [polypeptide binding]; other site
862967000099	ATP binding site [chemical binding]; other site
862967000100	Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740
862967000101	putative active site [active]
862967000102	catalytic triad [active]
862967000103	amidophosphoribosyltransferase; Provisional; Region: PRK07272
862967000104	Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of  glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715
862967000105	active site
862967000106	tetramer interface [polypeptide binding]; other site
862967000107	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
862967000108	active site
862967000109	phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385
862967000110	PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196
862967000111	dimerization interface [polypeptide binding]; other site
862967000112	putative ATP binding site [chemical binding]; other site
862967000113	phosphoribosylglycinamide formyltransferase; Reviewed; Region: purN; PRK05647
862967000114	Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645
862967000115	active site
862967000116	substrate binding site [chemical binding]; other site
862967000117	cosubstrate binding site; other site
862967000118	catalytic site [active]
862967000119	Suppressor of fused protein (SUFU); Region: SUFU; pfam05076
862967000120	bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881
862967000121	Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal  ATIC formylase domain that formylates...; Region: IMPCH; cd01421
862967000122	purine monophosphate binding site [chemical binding]; other site
862967000123	dimer interface [polypeptide binding]; other site
862967000124	putative catalytic residues [active]
862967000125	AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; smart00798
862967000126	AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; cl03362
862967000127	GBS Bsp-like repeat; Region: GBS_Bsp-like; pfam08481
862967000128	GBS Bsp-like repeat; Region: GBS_Bsp-like; pfam08481
862967000129	GBS Bsp-like repeat; Region: GBS_Bsp-like; pfam08481
862967000130	GBS Bsp-like repeat; Region: GBS_Bsp-like; pfam08481
862967000131	GBS Bsp-like repeat; Region: GBS_Bsp-like; pfam08481
862967000132	Surface antigen [General function prediction only]; Region: COG3942
862967000133	CHAP domain; Region: CHAP; pfam05257
862967000134	Beta protein; Region: Beta_protein; pfam14350
862967000135	Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826
862967000136	Integrase core domain; Region: rve; pfam00665
862967000137	Filoviridae VP35; Region: Filo_VP35; pfam02097
862967000138	phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885
862967000139	Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844
862967000140	Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Region: GARS_A; pfam01071
862967000141	Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843
862967000142	Phosphoribosylcarboxyaminoimidazole (NCAIR) mutase [Nucleotide transport and metabolism]; Region: PurE; COG0041
862967000143	phosphoribosylaminoimidazole carboxylase ATPase subunit; Reviewed; Region: PRK06019
862967000144	ATP-grasp domain; Region: ATP-grasp; pfam02222
862967000145	aspartate racemase; Region: asp_race; TIGR00035
862967000146	Aspartate racemase [Cell envelope biogenesis, outer membrane]; Region: RacX; COG1794
862967000147	adenylosuccinate lyase; Provisional; Region: PRK07492
862967000148	Adenylsuccinate lyase (ASL)_subgroup 1; Region: Adenylsuccinate_lyase_1; cd01360
862967000149	tetramer interface [polypeptide binding]; other site
862967000150	active site
862967000151	Adenylosuccinate lyase C-terminus; Region: ADSL_C; smart00998
862967000152	Transcriptional regulators [Transcription]; Region: PhnF; COG2188
862967000153	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
862967000154	DNA-binding site [nucleotide binding]; DNA binding site
862967000155	The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; Region: UTRA; smart00866
862967000156	Beta-galactosidase [Carbohydrate transport and metabolism]; Region: LacA; COG1874
862967000157	Glycosyl hydrolases family 35; Region: Glyco_hydro_35; pfam01301
862967000158	Beta-galactosidase jelly roll domain; Region: BetaGal_dom4_5; pfam13364
862967000159	PTS_IIB, PTS system, Mannose/sorbose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_man; cd00001
862967000160	active site
862967000161	phosphorylation site [posttranslational modification]
862967000162	Phosphotransferase system, mannose/fructose/N-acetylgalactosamine-specific component IIC [Carbohydrate transport and metabolism]; Region: ManY; COG3715
862967000163	PTS system mannose/fructose/sorbose family IID component; Region: EIID-AGA; pfam03613
862967000164	PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006
862967000165	active pocket/dimerization site; other site
862967000166	active site
862967000167	phosphorylation site [posttranslational modification]
862967000168	putative sugar isomerase, AgaS family; Region: agaS_fam; TIGR02815
862967000169	SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008
862967000170	dimer interface [polypeptide binding]; other site
862967000171	active site
862967000172	AgaS-like protein. AgaS contains a SIS (Sugar ISomerase) domain which is found in many phosphosugar isomerases and phosphosugar binding proteins. AgaS is a putative isomerase in Escherichia coli. It is similar to the glucosamine-6-phosphate synthases; Region: SIS_AgaS_like; cd05010
862967000173	putative active site [active]
862967000174	Class I aldolases; Region: Aldolase_Class_I; cl17187
862967000175	galactose mutarotase_like; Region: galactose_mutarotase_like; cd09019
862967000176	active site
862967000177	catalytic residues [active]
862967000178	FOG: Glucan-binding domain (YG repeat) [General function prediction only]; Region: COG5263
862967000179	Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080
862967000180	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
862967000181	Walker A motif; other site
862967000182	ATP binding site [chemical binding]; other site
862967000183	Walker B motif; other site
862967000184	arginine finger; other site
862967000185	Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491
862967000186	Bacterial protein of unknown function (DUF925); Region: DUF925; pfam06042
862967000187	fimbrial isopeptide formation D2 domain; Region: RrgB_K2N_iso_D2; TIGR04226
862967000188	Domain of unknown function DUF11; Region: DUF11; cl17728
862967000189	Repeat unit of collagen-binding protein domain B; Region: CollagenBindB; cd00222
862967000190	domain interaction interfaces [polypeptide binding]; other site
862967000191	LPXTG-motif cell wall anchor domain; Region: LPXTG_anchor; TIGR01167
862967000192	fimbrial isopeptide formation D2 domain; Region: RrgB_K2N_iso_D2; TIGR04226
862967000193	Cna protein B-type domain; Region: Cna_B; pfam05738
862967000194	LPXTG-motif cell wall anchor domain; Region: LPXTG_anchor; TIGR01167
862967000195	Sortase C (SrtC) or subfamily-3 sortases are membrane cysteine transpeptidases found in Gram-positive bacteria that anchor surface proteins to peptidoglycans of the bacterial cell wall envelope. This involves a transpeptidation reaction in which the...; Region: Sortase_C_3; cd05827
862967000196	active site
862967000197	catalytic site [active]
862967000198	Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394
862967000199	Low molecular weight phosphatase family; Region: LMWPc; cd00115
862967000200	active site
862967000201	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4642
862967000202	Predicted acyltransferases [Lipid metabolism]; Region: COG1835
862967000203	SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053
862967000204	active site
862967000205	catalytic triad [active]
862967000206	oxyanion hole [active]
862967000207	bifunctional acetaldehyde-CoA/alcohol dehydrogenase; Provisional; Region: PRK13805
862967000208	Coenzyme A acylating aldehyde dehydrogenase (ACDH), ALDH family 20-like; Region: ALDH_F20_ACDH; cd07122
862967000209	putative catalytic cysteine [active]
862967000210	C-terminal alcohol dehydrogenase domain of the acetaldehyde dehydrogenase-alcohol dehydrogenase bifunctional two-domain protein (AAD); Region: AAD_C; cd08178
862967000211	putative active site [active]
862967000212	metal binding site [ion binding]; metal-binding site
862967000213	N-acetylmannosamine-6-phosphate epimerase (NanE) converts N-acetylmannosamine-6-phosphate to N-acetylglucosamine-6-phosphate. This reaction is part of the pathway that allows the usage of sialic acid as a carbohydrate source. Sialic acids are a family of...; Region: NanE; cd04729
862967000214	N-acetylmannosamine-6-phosphate 2-epimerase; Provisional; Region: PRK01130
862967000215	putative active site cavity [active]
862967000216	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
862967000217	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
862967000218	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
862967000219	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427
862967000220	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
862967000221	putative PBP binding loops; other site
862967000222	dimer interface [polypeptide binding]; other site
862967000223	ABC-ATPase subunit interface; other site
862967000224	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
862967000225	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
862967000226	dimer interface [polypeptide binding]; other site
862967000227	conserved gate region; other site
862967000228	putative PBP binding loops; other site
862967000229	ABC-ATPase subunit interface; other site
862967000230	Domain of unknown function (DUF386); Region: DUF386; cl01047
862967000231	Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329
862967000232	Class I aldolases; Region: Aldolase_Class_I; cl17187
862967000233	catalytic residue [active]
862967000234	Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940
862967000235	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012
862967000236	nucleotide binding site [chemical binding]; other site
862967000237	Transcriptional regulators [Transcription]; Region: RpiR; COG1737
862967000238	Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418
862967000239	RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013
862967000240	putative active site [active]
862967000241	Uncharacterized conserved protein [Function unknown]; Region: COG3589
862967000242	Bacterial protein of unknown function (DUF871); Region: DUF871; pfam05913
862967000243	PTS system, sucrose-specific IIBC component; Region: PTS-II-BC-sucr; TIGR01996
862967000244	PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212
862967000245	active site turn [active]
862967000246	phosphorylation site [posttranslational modification]
862967000247	Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263
862967000248	N-acetylmuramic acid-6-phosphate etherase; Reviewed; Region: murQ; PRK05441
862967000249	N-acetylmuramic acid 6-phosphate etherase. Members of this family contain the SIS (Sugar ISomerase) domain. The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. The bacterial cell wall sugar N-acetylmuramic acid...; Region: SIS_Etherase; cd05007
862967000250	putative active site [active]
862967000251	Transcriptional regulators [Transcription]; Region: RpiR; COG1737
862967000252	Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418
862967000253	RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013
862967000254	putative active site [active]
862967000255	V-type ATP synthase subunit I; Validated; Region: PRK05771
862967000256	V-type ATP synthase subunit K; Validated; Region: PRK06558
862967000257	ATP synthase subunit C; Region: ATP-synt_C; pfam00137
862967000258	ATP synthase subunit C; Region: ATP-synt_C; pfam00137
862967000259	Archaeal/vacuolar-type H+-ATPase subunit C [Energy production and conversion]; Region: NtpC; COG1527
862967000260	V-type ATP synthase subunit C; Provisional; Region: PRK01198; cl00660
862967000261	V-type ATP synthase subunit F; Provisional; Region: PRK01395
862967000262	V-type ATP synthase subunit A; Provisional; Region: PRK04192
862967000263	ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874
862967000264	V/A-type ATP synthase catalytic subunit A. These ATPases couple ATP hydrolysis to the build up of a H+ gradient, but V-type ATPases do not catalyze the reverse reaction.  The Vacuolar (V-type) ATPase is found in the membranes of vacuoles, the golgi...; Region: V_A-ATPase_A; cd01134
862967000265	Walker A motif/ATP binding site; other site
862967000266	Walker B motif; other site
862967000267	ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306
862967000268	V-type ATP synthase subunit B; Provisional; Region: PRK04196
862967000269	ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874
862967000270	V/A-type ATP synthase (non-catalytic) subunit B. These ATPases couple ATP hydrolysis to the build up of a H+ gradient, but V-type ATPases do not catalyze the reverse reaction. The Vacuolar (V-type) ATPase is found in the membranes of vacuoles, the golgi...; Region: V_A-ATPase_B; cd01135
862967000271	Walker A motif homologous position; other site
862967000272	Walker B motif; other site
862967000273	ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306
862967000274	V-type ATP synthase subunit D; Reviewed; Region: PRK00373
862967000275	Threonine synthase catalyzes the final step of threonine biosynthesis. The conversion of O-phosphohomoserine into threonine and inorganic phosphate is pyridoxal 5'-phosphate dependent. The Thr-synth_1 CD includes members from higher plants; Region: Thr-synth_2; cd01560
862967000276	Threonine synthase [Amino acid transport and metabolism]; Region: ThrC; COG0498
862967000277	pyridoxal 5'-phosphate binding site [chemical binding]; other site
862967000278	catalytic residue [active]
862967000279	Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534
862967000280	Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Thermotoga marina NorM; Region: MATE_NorM_like; cd13137
862967000281	Haloacid dehalogenase-like hydrolase; Region: HAD_2; pfam13419
862967000282	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
862967000283	motif II; other site
862967000284	Collagen binding domain; Region: Collagen_bind; pfam05737
862967000285	Cna protein B-type domain; Region: Cna_B; pfam05738
862967000286	streptococcal pilin isopeptide linkage domain; Region: strep_pil_rpt; TIGR03786
862967000287	T surface-antigen of pili; Region: FctA; pfam12892
862967000288	streptococcal pilin isopeptide linkage domain; Region: strep_pil_rpt; TIGR03786
862967000289	streptococcal pilin isopeptide linkage domain; Region: strep_pil_rpt; TIGR03786
862967000290	T surface-antigen of pili; Region: FctA; pfam12892
862967000291	streptococcal pilin isopeptide linkage domain; Region: strep_pil_rpt; TIGR03786
862967000292	streptococcal pilin isopeptide linkage domain; Region: strep_pil_rpt; TIGR03786
862967000293	streptococcal pilin isopeptide linkage domain; Region: strep_pil_rpt; TIGR03786
862967000294	streptococcal pilin isopeptide linkage domain; Region: strep_pil_rpt; TIGR03786
862967000295	streptococcal pilin isopeptide linkage domain; Region: strep_pil_rpt; TIGR03786
862967000296	streptococcal pilin isopeptide linkage domain; Region: strep_pil_rpt; TIGR03786
862967000297	streptococcal pilin isopeptide linkage domain; Region: strep_pil_rpt; TIGR03786
862967000298	Thiol-activated cytolysin; Region: Thiol_cytolysin; pfam01289
862967000299	Winged helix DNA-binding domain; Region: HTH_27; pfam13463
862967000300	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
862967000301	ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235
862967000302	ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108
862967000303	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
862967000304	ABC-ATPase subunit  interface; other site
862967000305	dimer interface [polypeptide binding]; other site
862967000306	putative PBP binding regions; other site
862967000307	ABC-type metal ion transport system, periplasmic component/surface adhesin [Inorganic ion transport and metabolism]; Region: LraI; COG0803
862967000308	Metal binding protein AcdA.  These proteins have been shown to function in the ABC uptake of Zn2+ and Mn2+ and in competence for genetic transformation and adhesion. The AcdA proteins belong to the TroA superfamily of helical backbone metal receptor...; Region: AdcA; cd01017
862967000309	metal binding site [ion binding]; metal-binding site
862967000310	YodA lipocalin-like domain; Region: YodA; pfam09223
862967000311	copper transport repressor, CopY/TcrY family; Region: CopY_TcrY; TIGR02698
862967000312	Penicillinase repressor; Region: Pencillinase_R; pfam03965
862967000313	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217
862967000314	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371
862967000315	metal-binding site [ion binding]
862967000316	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
862967000317	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
862967000318	motif II; other site
862967000319	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371
862967000320	metal-binding site [ion binding]
862967000321	Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564
862967000322	Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869
862967000323	active site
862967000324	Transglycosylase; Region: Transgly; pfam00912
862967000325	penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074
862967000326	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760
862967000327	50S ribosomal protein L33; Validated; Region: rpmG; PRK00504
862967000328	transcription antitermination protein NusG; Validated; Region: nusG; PRK05609
862967000329	Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891
862967000330	putative homodimer interface [polypeptide binding]; other site
862967000331	NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091
862967000332	heterodimer interface [polypeptide binding]; other site
862967000333	homodimer interface [polypeptide binding]; other site
862967000334	Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425
862967000335	rRNA interaction site [nucleotide binding]; other site
862967000336	S8 interaction site; other site
862967000337	putative laminin-1 binding site; other site
862967000338	elongation factor Ts; Provisional; Region: tsf; PRK09377
862967000339	UBA/TS-N domain; Region: UBA; pfam00627
862967000340	Elongation factor TS; Region: EF_TS; pfam00889
862967000341	Elongation factor TS; Region: EF_TS; pfam00889
862967000342	Firmicute transcriptional repressor of class III stress genes (CtsR); Region: CtsR; pfam05848
862967000343	ATP-binding subunits of Clp protease and DnaK/DnaJ chaperones [Posttranslational modification, protein turnover, chaperones]; Region: clpA; COG0542
862967000344	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
862967000345	Walker A motif; other site
862967000346	ATP binding site [chemical binding]; other site
862967000347	Walker B motif; other site
862967000348	arginine finger; other site
862967000349	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
862967000350	Walker A motif; other site
862967000351	ATP binding site [chemical binding]; other site
862967000352	Walker B motif; other site
862967000353	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086
862967000354	putative acetyltransferase; Provisional; Region: PRK03624
862967000355	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
862967000356	Coenzyme A binding pocket [chemical binding]; other site
862967000357	putative TIM-barrel protein, nifR3 family; Region: nifR3_yhdG; TIGR00737
862967000358	Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801
862967000359	FMN binding site [chemical binding]; other site
862967000360	active site
862967000361	catalytic residues [active]
862967000362	substrate binding site [chemical binding]; other site
862967000363	Hsp33-like chaperonin; Reviewed; Region: hslO; PRK00114
862967000364	Heat shock protein 33 (Hsp33):  Cytosolic protein that acts as a molecular chaperone under oxidative conditions.  In normal (reducing) cytosolic conditions, four conserved Cys residues are coordinated by a Zn ion. Under oxidative stress (such as heat...; Region: Hsp33; cd00498
862967000365	dimerization interface [polypeptide binding]; other site
862967000366	domain crossover interface; other site
862967000367	redox-dependent activation switch; other site
862967000368	Uncharacterized protein involved in tellurite resistance [Inorganic ion transport and metabolism]; Region: TelA; COG3853
862967000369	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
862967000370	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
862967000371	non-specific DNA binding site [nucleotide binding]; other site
862967000372	salt bridge; other site
862967000373	sequence-specific DNA binding site [nucleotide binding]; other site
862967000374	transcriptional activator, Rgg/GadR/MutR family, C-terminal domain; Region: RGG_Cterm; TIGR01716
862967000375	Predicted Fe-S oxidoreductases [General function prediction only]; Region: COG0535
862967000376	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
862967000377	FeS/SAM binding site; other site
862967000378	Domain of unknown function (DUF4008); Region: DUF4008; cl14869
862967000379	Predicted Fe-S oxidoreductases [General function prediction only]; Region: COG0535
862967000380	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
862967000381	FeS/SAM binding site; other site
862967000382	radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085
862967000383	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
862967000384	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
862967000385	Walker A/P-loop; other site
862967000386	ATP binding site [chemical binding]; other site
862967000387	Q-loop/lid; other site
862967000388	ABC transporter signature motif; other site
862967000389	Walker B; other site
862967000390	D-loop; other site
862967000391	H-loop/switch region; other site
862967000392	Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673
862967000393	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
862967000394	Coenzyme A binding pocket [chemical binding]; other site
862967000395	Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788
862967000396	Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108
862967000397	GDP-binding site [chemical binding]; other site
862967000398	ACT binding site; other site
862967000399	IMP binding site; other site
862967000400	Restriction endonuclease; Region: Mrr_cat; pfam04471
862967000401	Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285
862967000402	nucleoside/Zn binding site; other site
862967000403	dimer interface [polypeptide binding]; other site
862967000404	catalytic motif [active]
862967000405	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
862967000406	non-specific DNA binding site [nucleotide binding]; other site
862967000407	salt bridge; other site
862967000408	sequence-specific DNA binding site [nucleotide binding]; other site
862967000409	transcriptional activator, Rgg/GadR/MutR family, C-terminal domain; Region: RGG_Cterm; TIGR01716
862967000410	acylglycerophosphoethanolamine acyltransferase; Provisional; Region: PRK06814
862967000411	glucose-6-phosphate isomerase; Provisional; Region: pgi; PRK14097
862967000412	Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015
862967000413	active site
862967000414	dimer interface [polypeptide binding]; other site
862967000415	Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016
862967000416	dimer interface [polypeptide binding]; other site
862967000417	active site
862967000418	glycerol kinase; Provisional; Region: glpK; PRK00047
862967000419	Escherichia coli glycerol kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_EcGK_like; cd07786
862967000420	N- and C-terminal domain interface [polypeptide binding]; other site
862967000421	active site
862967000422	MgATP binding site [chemical binding]; other site
862967000423	catalytic site [active]
862967000424	metal binding site [ion binding]; metal-binding site
862967000425	glycerol binding site [chemical binding]; other site
862967000426	homotetramer interface [polypeptide binding]; other site
862967000427	homodimer interface [polypeptide binding]; other site
862967000428	FBP binding site [chemical binding]; other site
862967000429	protein IIAGlc interface [polypeptide binding]; other site
862967000430	ribonuclease P; Reviewed; Region: rnpA; PRK00499
862967000431	Preprotein translocase subunit YidC [Intracellular trafficking and secretion]; Region: YidC; COG0706
862967000432	membrane protein insertase, YidC/Oxa1 family, C-terminal domain; Region: yidC_oxa1_cterm; TIGR03592
862967000433	Predicted RNA-binding protein [General function prediction only]; Region: Jag; COG1847
862967000434	jag_K homology RNA-binding domain. The KH domain is found in proteins homologous to the Bacillus subtilis protein Jag, which is associated with SpoIIIJ and is necessary for the third stage of sporulation.  The KH motif is a beta-alpha-alpha-beta-beta...; Region: jag_KH; cd02414
862967000435	G-X-X-G motif; other site
862967000436	R3H domain found in proteins homologous to Bacillus subtilus Jag, which is associated with SpoIIIJ. SpoIIIJ is necessary for the third stage of sporulation. The name of the R3H domain comes from the characteristic spacing of the most conserved arginine...; Region: R3H_jag; cd02644
862967000437	RxxxH motif; other site
862967000438	50S ribosomal protein L34; Reviewed; Region: rpmH; PRK00399
862967000439	TatD like proteins;  E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310
862967000440	Predicted metal-dependent hydrolases with the TIM-barrel fold [General function prediction only]; Region: COG1099
862967000441	active site
862967000442	ribonuclease M5; Region: 5S_RNA_mat_M5; TIGR00334
862967000443	TOPRIM_ RNase M5_like: The topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain found in Ribonuclease M5: (RNase M5) and other small primase-like proteins from bacteria and archaea.  RNase M5 catalyzes the maturation of 5S rRNA in low...; Region: TOPRIM_RNase_M5_like; cd01027
862967000444	putative active site [active]
862967000445	putative metal binding site [ion binding]; other site
862967000446	Domain of unknown function (DUF4093); Region: DUF4093; pfam13331
862967000447	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4842
862967000448	Domain of unknown function (DUF4176); Region: DUF4176; cl01867
862967000449	WXG100 protein secretion system (Wss), protein YukC; Region: YukC; cl01868
862967000450	type VII secretion protein EssB; Region: T7_EssB; TIGR03926
862967000451	type VII secretion protein EssC, C-terminal domain; Region: T7_EssCb_Firm; TIGR03928
862967000452	FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580
862967000453	FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580
862967000454	YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061
862967000455	LXG domain of WXG superfamily; Region: LXG; pfam04740
862967000456	Protein of unknown function (DUF4237); Region: DUF4237; pfam14021
862967000457	Protein of unknown function (DUF4237); Region: DUF4237; pfam14021
862967000458	Protein of unknown function (DUF4237); Region: DUF4237; pfam14021
862967000459	Malate synthase catalyzes the Claisen condensation of glyoxylate and acetyl-CoA to malyl-CoA , which hydrolyzes to malate and CoA. This reaction is part of the glyoxylate cycle, which allows certain organisms, like plants and fungi, to derive their...; Region: malate_synt; cl17217
862967000460	LXG domain of WXG superfamily; Region: LXG; pfam04740
862967000461	16S ribosomal RNA methyltransferase KsgA/Dim1 family protein; Reviewed; Region: ksgA; PRK00274
862967000462	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
862967000463	S-adenosylmethionine binding site [chemical binding]; other site
862967000464	GTPase RsgA; Reviewed; Region: PRK00098
862967000465	S1_YloQ_GTPase: YloQ GTase family (also known as YjeQ and CpgA), S1-like RNA-binding domain. Proteins in the YloQ GTase family bind the ribosome and have GTPase activity. The precise role of this family is unknown. The protein structure is composed of...; Region: S1_YloQ_GTPase; cd04466
862967000466	RNA binding site [nucleotide binding]; other site
862967000467	homodimer interface [polypeptide binding]; other site
862967000468	Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854
862967000469	GTPase/Zn-binding domain interface [polypeptide binding]; other site
862967000470	GTP/Mg2+ binding site [chemical binding]; other site
862967000471	G4 box; other site
862967000472	G5 box; other site
862967000473	G1 box; other site
862967000474	Switch I region; other site
862967000475	G2 box; other site
862967000476	G3 box; other site
862967000477	Switch II region; other site
862967000478	Pentose-5-phosphate-3-epimerase [Carbohydrate transport and metabolism]; Region: Rpe; COG0036
862967000479	Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429
862967000480	substrate binding site [chemical binding]; other site
862967000481	hexamer interface [polypeptide binding]; other site
862967000482	metal binding site [ion binding]; metal-binding site
862967000483	Thiamine pyrophosphokinase [Coenzyme metabolism]; Region: THI80; COG1564
862967000484	Thiamine pyrophosphokinase; Region: TPK; cd07995
862967000485	active site
862967000486	dimerization interface [polypeptide binding]; other site
862967000487	thiamine binding site [chemical binding]; other site
862967000488	Predicted nuclease of restriction endonuclease-like fold, RmuC family [General function prediction only]; Region: COG1322
862967000489	RmuC family; Region: RmuC; pfam02646
862967000490	Predicted HD-superfamily hydrolase [General function prediction only]; Region: COG3481
862967000491	YhaM_OBF_like: A subfamily of OB folds similar to that found in Bacillus subtilis YhaM and Staphylococcus aureus cmp-binding factor-1 (SaCBF1). Both these proteins are 3'-to-5'exoribonucleases. YhaM requires Mn2+ or Co2+ for activity and is...; Region: YhaM_OBF_like; cd04492
862967000492	generic binding surface II; other site
862967000493	generic binding surface I; other site
862967000494	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
862967000495	Zn2+ binding site [ion binding]; other site
862967000496	Mg2+ binding site [ion binding]; other site
862967000497	pur operon repressor; Provisional; Region: PRK09213
862967000498	Bacterial purine repressor, N-terminal; Region: PuR_N; pfam09182
862967000499	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
862967000500	active site
862967000501	S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368
862967000502	S17 interaction site [polypeptide binding]; other site
862967000503	S8 interaction site; other site
862967000504	16S rRNA interaction site [nucleotide binding]; other site
862967000505	streptomycin interaction site [chemical binding]; other site
862967000506	23S rRNA interaction site [nucleotide binding]; other site
862967000507	aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site
862967000508	30S ribosomal protein S7; Validated; Region: PRK05302
862967000509	elongation factor G; Reviewed; Region: PRK00007
862967000510	Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886
862967000511	G1 box; other site
862967000512	putative GEF interaction site [polypeptide binding]; other site
862967000513	GTP/Mg2+ binding site [chemical binding]; other site
862967000514	Switch I region; other site
862967000515	G2 box; other site
862967000516	G3 box; other site
862967000517	Switch II region; other site
862967000518	G4 box; other site
862967000519	G5 box; other site
862967000520	EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088
862967000521	EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434
862967000522	EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G.  Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713
862967000523	Glyceraldehyde-3-phosphate dehydrogenase/erythrose-4-phosphate dehydrogenase [Carbohydrate transport and metabolism]; Region: GapA; COG0057
862967000524	Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846
862967000525	Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800
862967000526	mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595
862967000527	Metallo-beta-lactamase superfamily; Region: Lactamase_B; pfam00753
862967000528	RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521
862967000529	hypothetical protein; Provisional; Region: PRK13667
862967000530	tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725
862967000531	Glycoprotease family; Region: Peptidase_M22; pfam00814
862967000532	ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575
862967000533	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
862967000534	Coenzyme A binding pocket [chemical binding]; other site
862967000535	UGMP family protein; Validated; Region: PRK09604
862967000536	tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725
862967000537	Carbamoyltransferase; Region: CmcH_NodU; pfam02543
862967000538	YCII-related domain; Region: YCII; cl00999
862967000539	CAAX protease self-immunity; Region: Abi; pfam02517
862967000540	Helix-Turn-Helix DNA binding domain of the transcription regulators TipAL, Mta, and SkgA; Region: HTH_TipAL-Mta; cd01106
862967000541	MerR HTH family regulatory protein; Region: MerR_1; pfam13411
862967000542	DNA binding residues [nucleotide binding]
862967000543	dimer interface [polypeptide binding]; other site
862967000544	TipAS antibiotic-recognition domain; Region: TipAS; pfam07739
862967000545	MutT homolog-1 (MTH1) is a member of the Nudix hydrolase superfamily. MTH1, the mammalian counterpart of MutT, hydrolyzes oxidized purine nucleoside triphosphates, such as 8-oxo-dGTP and 2-hydroxy-ATP, to monophosphates, thereby preventing the...; Region: MTH1; cd03427
862967000546	putative active site [active]
862967000547	nucleotide binding site [chemical binding]; other site
862967000548	nudix motif; other site
862967000549	putative metal binding site [ion binding]; other site
862967000550	HI0933-like protein; Region: HI0933_like; pfam03486
862967000551	Chromate resistance exported protein; Region: Chrome_Resist; cl01744
862967000552	YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cl00630
862967000553	putative active site [active]
862967000554	Membrane domain of glycerophosphoryl diester phosphodiesterase; Region: GPDPase_memb; cl01974
862967000555	Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584
862967000556	Glycerophosphodiester phosphodiesterase domain of uncharacterized bacterial glycerophosphodiester phosphodiesterases; Region: GDPD_memb_like; cd08579
862967000557	putative active site [active]
862967000558	catalytic site [active]
862967000559	putative metal binding site [ion binding]; other site
862967000560	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
862967000561	gallidermin-class lantibiotic protection ABC transporter, ATP-binding subunit; Region: galliderm_ABC; TIGR03740
862967000562	Walker A/P-loop; other site
862967000563	ATP binding site [chemical binding]; other site
862967000564	Q-loop/lid; other site
862967000565	ABC transporter signature motif; other site
862967000566	Walker B; other site
862967000567	D-loop; other site
862967000568	H-loop/switch region; other site
862967000569	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
862967000570	non-specific DNA binding site [nucleotide binding]; other site
862967000571	salt bridge; other site
862967000572	sequence-specific DNA binding site [nucleotide binding]; other site
862967000573	Tetratricopeptide repeat; Region: TPR_12; pfam13424
862967000574	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429
862967000575	binding surface
862967000576	TPR motif; other site
862967000577	hypothetical protein; Validated; Region: PRK00153
862967000578	x-prolyl-dipeptidyl aminopeptidase; Provisional; Region: PRK05371
862967000579	X-Prolyl dipeptidyl aminopeptidase PepX, N-terminal; Region: PepX_N; pfam09168
862967000580	X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain; Region: PepX_C; pfam08530
862967000581	Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cd00333
862967000582	amphipathic channel; other site
862967000583	Asn-Pro-Ala signature motifs; other site
862967000584	Short repeat of unknown function (DUF308); Region: DUF308; cl15828
862967000585	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632
862967000586	Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680
862967000587	Beta-lactamase; Region: Beta-lactamase; pfam00144
862967000588	Mevalonate kinase [Lipid metabolism]; Region: ERG12; COG1577
862967000589	GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288
862967000590	diphosphomevalonate decarboxylase; Region: PLN02407
862967000591	diphosphomevalonate decarboxylase; Region: mevDPdecarb; TIGR01240
862967000592	Mevalonate kinase [Lipid metabolism]; Region: ERG12; COG1577
862967000593	GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544
862967000594	isopentenyl pyrophosphate isomerase; Provisional; Region: PRK05437
862967000595	Isopentenyl-diphosphate:dimethylallyl diphosphate isomerase type 2 (IDI-2) FMN-binding domain. Two types of IDIs have been characterized at present. The long known IDI-1 is only dependent on divalent metals for activity, whereas IDI-2 requires a metal; Region: IDI-2_FMN; cd02811
862967000596	homotetramer interface [polypeptide binding]; other site
862967000597	FMN binding site [chemical binding]; other site
862967000598	homodimer contacts [polypeptide binding]; other site
862967000599	putative active site [active]
862967000600	putative substrate binding site [chemical binding]; other site
862967000601	Class II hydroxymethylglutaryl-coenzyme A (HMG-CoA) reductase (HMGR); Region: HMG-CoA_reductase_classII; cd00644
862967000602	homodimer interface [polypeptide binding]; other site
862967000603	catalytic residues [active]
862967000604	NAD binding site [chemical binding]; other site
862967000605	substrate binding pocket [chemical binding]; other site
862967000606	flexible flap; other site
862967000607	"initiating" condensing enzymes are a subclass of decarboxylating condensing enzymes, including beta-ketoacyl [ACP] synthase, type III and polyketide synthases, type III, which include chalcone synthase and related enzymes. They are...; Region: init_cond_enzymes; cd00827
862967000608	3-hydroxy-3-methylglutaryl CoA synthase, prokaryotic clade; Region: HMG-CoA-S_prok; TIGR01835
862967000609	dimer interface [polypeptide binding]; other site
862967000610	active site
862967000611	Uncharacterized conserved protein [Function unknown]; Region: COG3610
862967000612	Uncharacterized conserved protein [Function unknown]; Region: COG2966
862967000613	Protein of unknown function (DUF1212); Region: DUF1212; pfam06738
862967000614	formate acetyltransferase 1; Region: pyr_form_ly_1; TIGR01255
862967000615	Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939
862967000616	DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586
862967000617	active site
862967000618	DNA polymerase IV; Validated; Region: PRK02406
862967000619	DNA binding site [nucleotide binding]
862967000620	helicase, putative, RecD/TraA family; Region: recD_rel; TIGR01448
862967000621	Ras GTPase Activating Domain; Region: RasGAP; cl02569
862967000622	AAA domain; Region: AAA_30; pfam13604
862967000623	Family description; Region: UvrD_C_2; pfam13538
862967000624	signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227
862967000625	The S24, S26 LexA/signal peptidase superfamily contains LexA-related and type I signal peptidase families. The S24 LexA protein domains include: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC 3.4.21.88), the...; Region: Peptidase_S24_S26; cd06462
862967000626	Catalytic site [active]
862967000627	The S24, S26 LexA/signal peptidase superfamily contains LexA-related and type I signal peptidase families. The S24 LexA protein domains include: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC 3.4.21.88), the...; Region: Peptidase_S24_S26; cl10465
862967000628	ribonuclease HIII; Provisional; Region: PRK00996
862967000629	Domain of unknown function (DUF3378); Region: DUF3378; pfam11858
862967000630	bacterial Ribonuclease HIII-like; Region: RNase_HII_bacteria_HIII_like; cd06590
862967000631	RNA/DNA hybrid binding site [nucleotide binding]; other site
862967000632	active site
862967000633	Uncharacterized membrane protein, required for colicin V production [General function prediction only]; Region: CvpA; COG1286
862967000634	Colicin V production protein; Region: Colicin_V; pfam02674
862967000635	recombination and DNA strand exchange inhibitor protein; Reviewed; Region: PRK00409
862967000636	MutS domain III; Region: MutS_III; pfam05192
862967000637	ATP-binding cassette domain of MutS2; Region: ABC_MutS2; cd03280
862967000638	Walker A/P-loop; other site
862967000639	ATP binding site [chemical binding]; other site
862967000640	Q-loop/lid; other site
862967000641	ABC transporter signature motif; other site
862967000642	Walker B; other site
862967000643	D-loop; other site
862967000644	H-loop/switch region; other site
862967000645	Smr domain; Region: Smr; pfam01713
862967000646	Peptidase family C69; Region: Peptidase_C69; pfam03577
862967000647	TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947
862967000648	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
862967000649	catalytic residues [active]
862967000650	Transcriptional regulator [Transcription]; Region: LysR; COG0583
862967000651	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
862967000652	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
862967000653	START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643
862967000654	hydrophobic ligand binding site; other site
862967000655	Amino acid permease; Region: AA_permease_2; pfam13520
862967000656	Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668
862967000657	Mechanosensitive ion channel; Region: MS_channel; pfam00924
862967000658	Predicted Zn-dependent protease (DUF2268); Region: DUF2268; pfam10026
862967000659	EXLDI protein; Region: EXLDI; TIGR04342
862967000660	glutamate dehydrogenase; Provisional; Region: PRK09414
862967000661	Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812
862967000662	NAD(P) binding domain of glutamate dehydrogenase, subgroup 2; Region: NAD_bind_2_Glu_DH; cd05313
862967000663	NAD(P) binding site [chemical binding]; other site
862967000664	dihydroorotate dehydrogenase (subfamily 1) family protein; Region: pyrD_sub1_fam; TIGR01037
862967000665	Dihydroorotate dehydrogenase (DHOD) class 1A FMN-binding domain. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine...; Region: DHOD_1A_like; cd04741
862967000666	active site
862967000667	FMN binding site [chemical binding]; other site
862967000668	substrate binding site [chemical binding]; other site
862967000669	catalytic residues [active]
862967000670	homodimer interface [polypeptide binding]; other site
862967000671	Peptide methionine sulfoxide reductase [Posttranslational modification, protein turnover, chaperones]; Region: MsrA; COG0225
862967000672	Conserved domain frequently associated with peptide methionine sulfoxide reductase [Posttranslational modification, protein turnover, chaperones]; Region: COG0229
862967000673	SelR domain; Region: SelR; pfam01641
862967000674	chlorohydrolase; Validated; Region: PRK06687
862967000675	TRZ/ATZ family contains enzymes from the atrazine degradation pathway and related hydrolases. Atrazine, a chlorinated herbizide, can be catabolized by a variety of different bacteria. The first three steps of the atrazine dehalogenation pathway are...; Region: ATZ_TRZ_like; cd01298
862967000676	active site
862967000677	putative substrate binding pocket [chemical binding]; other site
862967000678	Bacteriocin (Lactococcin_972); Region: Lactococcin_972; cl09891
862967000679	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4652
862967000680	Protein of unknown function (DUF1430); Region: DUF1430; pfam07242
862967000681	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
862967000682	putative bacteriocin export ABC transporter, lactococcin 972 group; Region: L_ocin_972_ABC; TIGR03608
862967000683	Walker A/P-loop; other site
862967000684	ATP binding site [chemical binding]; other site
862967000685	Q-loop/lid; other site
862967000686	ABC transporter signature motif; other site
862967000687	Walker B; other site
862967000688	D-loop; other site
862967000689	H-loop/switch region; other site
862967000690	helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cl17320
862967000691	non-specific DNA interactions [nucleotide binding]; other site
862967000692	DNA binding site [nucleotide binding]
862967000693	sequence specific DNA binding site [nucleotide binding]; other site
862967000694	putative cAMP binding site [chemical binding]; other site
862967000695	Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940
862967000696	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012
862967000697	nucleotide binding site [chemical binding]; other site
862967000698	Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455
862967000699	cellobiose phosphotransferase system IIC component; Reviewed; Region: celD; PRK09592
862967000700	TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186
862967000701	Carbohydrate binding domain; Region: CBM_4_9; pfam02018
862967000702	Laminarinase, member of the glycosyl hydrolase family 16; Region: GH16_laminarinase_like; cd08023
862967000703	active site
862967000704	catalytic residues [active]
862967000705	PTS_IIB_chitobiose_lichenan: subunit IIB of enzyme II (EII) of the N,N-diacetylchitobiose-specific and lichenan-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In these systems, EII is either a lichenan- or an N; Region: PTS_IIB_chitobiose_lichenan; cd05564
862967000706	active site
862967000707	P-loop; other site
862967000708	phosphorylation site [posttranslational modification]
862967000709	PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_lac; cd00215
862967000710	active site
862967000711	methionine cluster; other site
862967000712	phosphorylation site [posttranslational modification]
862967000713	metal binding site [ion binding]; metal-binding site
862967000714	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
862967000715	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
862967000716	Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Streptococcus aureus MepA; Region: MATE_MepA_like; cd13143
862967000717	Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534
862967000718	Protein of unknown function with HXXEE motif; Region: HXXEE; pfam13787
862967000719	AraC-like ligand binding domain; Region: AraC_binding; pfam02311
862967000720	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
862967000721	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
862967000722	Beta-glucosidase/6-phospho-beta-glucosidase/beta- galactosidase [Carbohydrate transport and metabolism]; Region: BglB; COG2723
862967000723	beta-galactosidase; Region: BGL; TIGR03356
862967000724	CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311
862967000725	substrate binding site [chemical binding]; other site
862967000726	THF binding site; other site
862967000727	zinc-binding site [ion binding]; other site
862967000728	hypothetical protein; Provisional; Region: PRK07329
862967000729	Polymerase and Histidinol Phosphatase domain; Region: PHP; cl17102
862967000730	active site
862967000731	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
862967000732	ATPases associated with a variety of cellular activities; Region: AAA; smart00382
862967000733	Walker A motif; other site
862967000734	ATP binding site [chemical binding]; other site
862967000735	Walker B motif; other site
862967000736	arginine finger; other site
862967000737	McrBC 5-methylcytosine restriction system component; Region: McrBC; cl01737
862967000738	Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670
862967000739	Predicted acetyltransferase [General function prediction only]; Region: COG3981
862967000740	Glycosyl hydrolase family 1; Region: Glyco_hydro_1; cl01046
862967000741	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
862967000742	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
862967000743	active site
862967000744	phosphorylation site [posttranslational modification]
862967000745	intermolecular recognition site; other site
862967000746	dimerization interface [polypeptide binding]; other site
862967000747	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
862967000748	DNA binding site [nucleotide binding]
862967000749	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
862967000750	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
862967000751	dimer interface [polypeptide binding]; other site
862967000752	phosphorylation site [posttranslational modification]
862967000753	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
862967000754	ATP binding site [chemical binding]; other site
862967000755	Mg2+ binding site [ion binding]; other site
862967000756	G-X-G motif; other site
862967000757	ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730
862967000758	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
862967000759	ATP-binding cassette domain of the bacitracin-resistance transporter; Region: ABC_BcrA_bacitracin_resist; cd03268
862967000760	Walker A/P-loop; other site
862967000761	ATP binding site [chemical binding]; other site
862967000762	Q-loop/lid; other site
862967000763	ABC transporter signature motif; other site
862967000764	Walker B; other site
862967000765	D-loop; other site
862967000766	H-loop/switch region; other site
862967000767	alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403
862967000768	Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333
862967000769	Ca binding site [ion binding]; other site
862967000770	active site
862967000771	catalytic site [active]
862967000772	Beta-galactosidase C-terminal domain; Region: Glyco_hydro_42C; pfam08533
862967000773	ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122
862967000774	First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225
862967000775	Walker A/P-loop; other site
862967000776	ATP binding site [chemical binding]; other site
862967000777	Q-loop/lid; other site
862967000778	ABC transporter signature motif; other site
862967000779	Walker B; other site
862967000780	D-loop; other site
862967000781	H-loop/switch region; other site
862967000782	ABC-type transport system involved in cytochrome c biogenesis, ATPase component [Posttranslational modification, protein turnover, chaperones]; Region: CcmA; COG4133
862967000783	First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225
862967000784	Walker A/P-loop; other site
862967000785	ATP binding site [chemical binding]; other site
862967000786	Q-loop/lid; other site
862967000787	ABC transporter signature motif; other site
862967000788	Walker B; other site
862967000789	D-loop; other site
862967000790	H-loop/switch region; other site
862967000791	ABC-type cobalt transport system, permease component; Region: ABC_cobalt; cl01943
862967000792	5-methyltetrahydropteroyltriglutamate--homocysteine S-methyltransferase; Provisional; Region: PRK05222
862967000793	CIMS - Cobalamine-independent methonine synthase, or MetE, N-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_N_terminal_like; cd03312
862967000794	THF binding site; other site
862967000795	CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311
862967000796	substrate binding site [chemical binding]; other site
862967000797	THF binding site; other site
862967000798	zinc-binding site [ion binding]; other site
862967000799	CDP-diacylglycerol pyrophosphatase; Region: CDH; cl00934
862967000800	TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947
862967000801	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
862967000802	catalytic residues [active]
862967000803	Predicted periplasmic protein (DUF2233); Region: DUF2233; pfam09992
862967000804	DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179
862967000805	Ligand binding site; other site
862967000806	Putative Catalytic site; other site
862967000807	DXD motif; other site
862967000808	GtrA-like protein; Region: GtrA; pfam04138
862967000809	30S ribosomal protein S6; Reviewed; Region: rpsF; PRK00453
862967000810	Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629
862967000811	SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496
862967000812	dimer interface [polypeptide binding]; other site
862967000813	ssDNA binding site [nucleotide binding]; other site
862967000814	tetramer (dimer of dimers) interface [polypeptide binding]; other site
862967000815	30S ribosomal protein S18; Reviewed; Region: rpsR; PRK00391
862967000816	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
862967000817	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
862967000818	Coenzyme A binding pocket [chemical binding]; other site
862967000819	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
862967000820	Protein of unknown function (DUF1129); Region: DUF1129; cl11555
862967000821	Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598
862967000822	uncharacterized bacterial subfamily of the Escherichia coli CorA-Salmonella typhimurium ZntB family; Region: EcCorA_ZntB-like_u2; cd12827
862967000823	Cl binding site [ion binding]; other site
862967000824	oligomer interface [polypeptide binding]; other site
862967000825	excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349
862967000826	ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270
862967000827	ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270
862967000828	ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271
862967000829	Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006
862967000830	Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321
862967000831	Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092
862967000832	active site
862967000833	elongation factor P; Validated; Region: PRK00529
862967000834	Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207
862967000835	S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470
862967000836	RNA binding site [nucleotide binding]; other site
862967000837	S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794
862967000838	RNA binding site [nucleotide binding]; other site
862967000839	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1302
862967000840	transcription antitermination protein NusB; Reviewed; Region: nusB; PRK00202
862967000841	putative RNA binding site [nucleotide binding]; other site
862967000842	Uncharacterized conserved protein [Function unknown]; Region: COG1912
862967000843	hypothetical protein; Provisional; Region: PRK13661
862967000844	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
862967000845	non-specific DNA binding site [nucleotide binding]; other site
862967000846	salt bridge; other site
862967000847	sequence-specific DNA binding site [nucleotide binding]; other site
862967000848	Phosphorylase superfamily; Region: PNP_UDP_1; pfam01048
862967000849	ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122
862967000850	First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225
862967000851	Walker A/P-loop; other site
862967000852	ATP binding site [chemical binding]; other site
862967000853	Q-loop/lid; other site
862967000854	ABC transporter signature motif; other site
862967000855	Walker B; other site
862967000856	D-loop; other site
862967000857	H-loop/switch region; other site
862967000858	ATP-binding cassette cobalt transporter; Region: DUF3744; pfam12558
862967000859	ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122
862967000860	First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225
862967000861	Walker A/P-loop; other site
862967000862	ATP binding site [chemical binding]; other site
862967000863	Q-loop/lid; other site
862967000864	ABC transporter signature motif; other site
862967000865	Walker B; other site
862967000866	D-loop; other site
862967000867	H-loop/switch region; other site
862967000868	ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619
862967000869	malonic semialdehyde reductase; Provisional; Region: PRK10538
862967000870	classical (c) SDR, subgroup 5; Region: SDR_c5; cd05346
862967000871	putative NAD(P) binding site [chemical binding]; other site
862967000872	homotetramer interface [polypeptide binding]; other site
862967000873	homodimer interface [polypeptide binding]; other site
862967000874	active site
862967000875	Predicted S-adenosylmethionine-dependent methyltransferase involved in bacterial cell division [Cell envelope biogenesis, outer membrane]; Region: GidB; COG0357
862967000876	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
862967000877	S-adenosylmethionine binding site [chemical binding]; other site
862967000878	Uncharacterized conserved protein [Function unknown]; Region: LemA; COG1704
862967000879	heat shock protein HtpX; Provisional; Region: PRK04897
862967000880	Predicted metal-binding, possibly nucleic acid-binding protein [General function prediction only]; Region: COG1399
862967000881	6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599
862967000882	6-phosphogluconate dehydrogenase; Validated; Region: PRK09287
862967000883	6-phosphogluconate dehydrogenase, C-terminal domain; Region: 6PGD; pfam00393
862967000884	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
862967000885	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
862967000886	active site
862967000887	phosphorylation site [posttranslational modification]
862967000888	intermolecular recognition site; other site
862967000889	dimerization interface [polypeptide binding]; other site
862967000890	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
862967000891	DNA binding site [nucleotide binding]
862967000892	Phosphotransferase system IIA components [Carbohydrate transport and metabolism]; Region: NagE; COG2190
862967000893	HPr interaction site; other site
862967000894	glycerol kinase (GK) interaction site [polypeptide binding]; other site
862967000895	active site
862967000896	phosphorylation site [posttranslational modification]
862967000897	Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263
862967000898	PTS system, IIBC component; Region: PTS-II-BC-unk1; TIGR02003
862967000899	PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212
862967000900	active site turn [active]
862967000901	phosphorylation site [posttranslational modification]
862967000902	Phosphotransferase system IIA components [Carbohydrate transport and metabolism]; Region: NagE; COG2190
862967000903	HPr interaction site; other site
862967000904	glycerol kinase (GK) interaction site [polypeptide binding]; other site
862967000905	active site
862967000906	phosphorylation site [posttranslational modification]
862967000907	Streptococcus agalactiae RgfB, part of a putative two component signal transduction system, and related proteins; Region: RgfB-like; cd09079
862967000908	putative catalytic site [active]
862967000909	putative metal binding site [ion binding]; other site
862967000910	putative phosphate binding site [ion binding]; other site
862967000911	transcriptional regulator NrdR; Validated; Region: nrdR; PRK00464
862967000912	ATP cone domain; Region: ATP-cone; pfam03477
862967000913	Replication initiation/membrane attachment protein [DNA replication, recombination, and repair]; Region: DnaB; COG3611
862967000914	primosomal protein DnaI; Reviewed; Region: PRK08939
862967000915	Primosomal protein DnaI N-terminus; Region: DnaI_N; pfam07319
862967000916	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
862967000917	Walker A motif; other site
862967000918	ATP binding site [chemical binding]; other site
862967000919	Walker B motif; other site
862967000920	This family contains NADPH-dependent flavin reductase and oxygen-insensitive nitroreductase. These enzymes are homodimeric flavoproteins that contain one FMN per monomer as a cofactor. Flavin reductase catalyzes the reduction of flavin by using NADPH as...; Region: NfsA_FRP; cd02146
862967000921	dimer interface [polypeptide binding]; other site
862967000922	FMN binding site [chemical binding]; other site
862967000923	NADPH bind site [chemical binding]; other site
862967000924	GTP-binding protein Der; Reviewed; Region: PRK00093
862967000925	EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894
862967000926	G1 box; other site
862967000927	GTP/Mg2+ binding site [chemical binding]; other site
862967000928	Switch I region; other site
862967000929	G2 box; other site
862967000930	Switch II region; other site
862967000931	G3 box; other site
862967000932	G4 box; other site
862967000933	G5 box; other site
862967000934	EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895
862967000935	G1 box; other site
862967000936	GTP/Mg2+ binding site [chemical binding]; other site
862967000937	Switch I region; other site
862967000938	G2 box; other site
862967000939	G3 box; other site
862967000940	Switch II region; other site
862967000941	G4 box; other site
862967000942	G5 box; other site
862967000943	Bacterial SNF2 helicase associated; Region: SNF2_assoc; pfam08455
862967000944	SNF2 family N-terminal domain; Region: SNF2_N; pfam00176
862967000945	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
862967000946	ATP binding site [chemical binding]; other site
862967000947	putative Mg++ binding site [ion binding]; other site
862967000948	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
862967000949	nucleotide binding region [chemical binding]; other site
862967000950	ATP-binding site [chemical binding]; other site
862967000951	UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421
862967000952	Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225
862967000953	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
862967000954	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
862967000955	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
862967000956	Coenzyme A binding pocket [chemical binding]; other site
862967000957	Acetyltransferase (GNAT) domain; Region: Acetyltransf_4; pfam13420
862967000958	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
862967000959	Coenzyme A binding pocket [chemical binding]; other site
862967000960	Aminodeoxychorismate lyase [Coenzyme transport and metabolism]; Region: COG1559
862967000961	proteins similar to Escherichia coli yceG; Region: yceG_like; cd08010
862967000962	dimerization interface [polypeptide binding]; other site
862967000963	transcription elongation factor GreA; Reviewed; Region: greA; PRK00226
862967000964	Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449
862967000965	Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272
862967000966	MutT homolog-1 (MTH1) is a member of the Nudix hydrolase superfamily. MTH1, the mammalian counterpart of MutT, hydrolyzes oxidized purine nucleoside triphosphates, such as 8-oxo-dGTP and 2-hydroxy-ATP, to monophosphates, thereby preventing the...; Region: MTH1; cd03427
862967000967	putative active site [active]
862967000968	nucleotide binding site [chemical binding]; other site
862967000969	nudix motif; other site
862967000970	putative metal binding site [ion binding]; other site
862967000971	OxaA-like protein precursor; Provisional; Region: PRK02463
862967000972	membrane protein insertase, YidC/Oxa1 family, C-terminal domain; Region: yidC_oxa1_cterm; TIGR03592
862967000973	acylphosphatase; Provisional; Region: PRK14434
862967000974	rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566
862967000975	RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; smart00967
862967000976	SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588
862967000977	Predicted HD superfamily hydrolase [General function prediction only]; Region: COG1418
862967000978	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
862967000979	Zn2+ binding site [ion binding]; other site
862967000980	Mg2+ binding site [ion binding]; other site
862967000981	Integral membrane protein, interacts with FtsH [General function prediction only]; Region: COG0670
862967000982	Bacterial BAX inhibitor (BI)-1/YccA-like proteins; Region: BI-1-like_bacterial; cd10432
862967000983	Diaminopimelate decarboxylase [Amino acid transport and metabolism]; Region: LysA; COG0019
862967000984	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828
862967000985	active site
862967000986	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
862967000987	substrate binding site [chemical binding]; other site
862967000988	catalytic residues [active]
862967000989	dimer interface [polypeptide binding]; other site
862967000990	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3763
862967000991	glutamate racemase; Provisional; Region: PRK00865
862967000992	putative deoxyribonucleotide triphosphate pyrophosphatase/unknown domain fusion protein; Reviewed; Region: PRK02491
862967000993	NTPase/HAM1.  This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515
862967000994	active site
862967000995	dimerization interface [polypeptide binding]; other site
862967000996	Escherichia coli YfcE and related proteins, metallophosphatase domain; Region: MPP_YfcE; cd00841
862967000997	active site
862967000998	metal binding site [ion binding]; metal-binding site
862967000999	homotetramer interface [polypeptide binding]; other site
862967001000	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_30; cd04643
862967001001	FOG: CBS domain [General function prediction only]; Region: COG0517
862967001002	site-specific tyrosine recombinase XerD-like protein; Reviewed; Region: xerD; PRK02436
862967001003	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
862967001004	DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182
862967001005	DNA binding site [nucleotide binding]
862967001006	Int/Topo IB signature motif; other site
862967001007	active site
862967001008	catalytic residues [active]
862967001009	segregation and condensation protein A; Reviewed; Region: scpA; PRK00104
862967001010	segregation and condensation protein B; Reviewed; Region: scpB; PRK00135
862967001011	16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187
862967001012	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
862967001013	RNA binding surface [nucleotide binding]; other site
862967001014	Pseudouridine synthases, RsuA subfamily; Region: PseudoU_synth_RsuA_like; cd02870
862967001015	active site
862967001016	hypothetical protein; Validated; Region: PRK00041
862967001017	Trk-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: TrkG; COG0168
862967001018	potassium uptake protein, TrkH family; Region: 2a38; TIGR00933
862967001019	TrkA-N domain; Region: TrkA_N; pfam02254
862967001020	potassium transporter peripheral membrane component; Reviewed; Region: trkA; PRK09496
862967001021	TrkA-C domain; Region: TrkA_C; pfam02080
862967001022	TrkA-N domain; Region: TrkA_N; pfam02254
862967001023	TrkA-C domain; Region: TrkA_C; pfam02080
862967001024	Predicted rRNA methylase (SpoU class) [Translation, ribosomal structure and biogenesis]; Region: CspR; COG0219
862967001025	Predicted membrane protein [Function unknown]; Region: COG3601
862967001026	Protein of unknown function (DUF3816); Region: DUF3816; pfam12822
862967001027	Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671
862967001028	PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392
862967001029	active site
862967001030	The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445
862967001031	active site
862967001032	DNA binding site [nucleotide binding]
862967001033	Predicted Fe-S oxidoreductase [General function prediction only]; Region: COG1242
862967001034	Putative rRNA methylase; Region: rRNA_methylase; pfam06962
862967001035	NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025
862967001036	Domain of unknown function (DUF1827); Region: DUF1827; pfam08860
862967001037	Contains a crystal structure of the Nudix hydrolase from Enterococcus faecalis, which has an unknown function. In general, members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes...; Region: Nudix_Hydrolase_25; cd04684
862967001038	nudix motif; other site
862967001039	HTH domain; Region: HTH_11; pfam08279
862967001040	Predicted transcriptional regulator [Transcription]; Region: COG2378
862967001041	WYL domain; Region: WYL; pfam13280
862967001042	GyrI-like small molecule binding domain; Region: GyrI-like; cl01368
862967001043	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
862967001044	ATPases associated with a variety of cellular activities; Region: AAA; smart00382
862967001045	Walker A motif; other site
862967001046	ATP binding site [chemical binding]; other site
862967001047	Walker B motif; other site
862967001048	arginine finger; other site
862967001049	UvrB/uvrC motif; Region: UVR; pfam02151
862967001050	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
862967001051	ATPases associated with a variety of cellular activities; Region: AAA; smart00382
862967001052	Walker A motif; other site
862967001053	ATP binding site [chemical binding]; other site
862967001054	Walker B motif; other site
862967001055	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431
862967001056	Protein of unknown function (DUF1797); Region: DUF1797; cl11550
862967001057	Protein of unknown function (DUF1706); Region: DUF1706; pfam08020
862967001058	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
862967001059	ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577
862967001060	FtsX-like permease family; Region: FtsX; pfam02687
862967001061	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
862967001062	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
862967001063	Walker A/P-loop; other site
862967001064	ATP binding site [chemical binding]; other site
862967001065	Q-loop/lid; other site
862967001066	ABC transporter signature motif; other site
862967001067	Walker B; other site
862967001068	D-loop; other site
862967001069	H-loop/switch region; other site
862967001070	ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577
862967001071	FtsX-like permease family; Region: FtsX; pfam02687
862967001072	bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK14179
862967001073	Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763
862967001074	NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080
862967001075	homodimer interface [polypeptide binding]; other site
862967001076	NADP binding site [chemical binding]; other site
862967001077	substrate binding site [chemical binding]; other site
862967001078	B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171
862967001079	putative substrate binding site [chemical binding]; other site
862967001080	putative ATP binding site [chemical binding]; other site
862967001081	Transcriptional regulators [Transcription]; Region: PurR; COG1609
862967001082	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
862967001083	DNA binding site [nucleotide binding]
862967001084	domain linker motif; other site
862967001085	Ligand binding domain of the lacI-like transcription regulator from a novel metal-reducing bacterium Alkaliphilus Metalliredigens (strain Qymf) and its close homologs; Region: PBP1_Qymf_like; cd06291
862967001086	dimerization interface [polypeptide binding]; other site
862967001087	ligand binding site [chemical binding]; other site
862967001088	sodium binding site [ion binding]; other site
862967001089	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
862967001090	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
862967001091	ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209
862967001092	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
862967001093	putative PBP binding loops; other site
862967001094	dimer interface [polypeptide binding]; other site
862967001095	ABC-ATPase subunit interface; other site
862967001096	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
862967001097	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
862967001098	dimer interface [polypeptide binding]; other site
862967001099	conserved gate region; other site
862967001100	putative PBP binding loops; other site
862967001101	ABC-ATPase subunit interface; other site
862967001102	Beta-fructosidases (levanase/invertase) [Carbohydrate transport and metabolism]; Region: SacC; COG1621
862967001103	Glycosyl hydrolase family 32, beta-fructosidases; Region: GH32_B_Fructosidase; cd08996
862967001104	substrate binding [chemical binding]; other site
862967001105	active site
862967001106	Acyl-CoA thioester hydrolase/BAAT N-terminal region; Region: Bile_Hydr_Trans; pfam04775
862967001107	BAAT / Acyl-CoA thioester hydrolase C terminal; Region: BAAT_C; pfam08840
862967001108	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
862967001109	MarR family; Region: MarR_2; pfam12802
862967001110	exodeoxyribonuclease VII large subunit; Reviewed; Region: xseA; PRK00286
862967001111	ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489
862967001112	generic binding surface II; other site
862967001113	generic binding surface I; other site
862967001114	exodeoxyribonuclease VII small subunit; Provisional; Region: PRK00977
862967001115	Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142
862967001116	Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685
862967001117	substrate binding pocket [chemical binding]; other site
862967001118	chain length determination region; other site
862967001119	substrate-Mg2+ binding site; other site
862967001120	catalytic residues [active]
862967001121	aspartate-rich region 1; other site
862967001122	active site lid residues [active]
862967001123	aspartate-rich region 2; other site
862967001124	Predicted rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: COG1189
862967001125	S4 RNA-binding domain; Region: S4; smart00363
862967001126	RNA binding surface [nucleotide binding]; other site
862967001127	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
862967001128	S-adenosylmethionine binding site [chemical binding]; other site
862967001129	Arginine repressor [Transcription]; Region: ArgR; COG1438
862967001130	Arginine repressor, DNA binding domain; Region: Arg_repressor; pfam01316
862967001131	Arginine repressor, C-terminal domain; Region: Arg_repressor_C; pfam02863
862967001132	ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: RecN; COG0497
862967001133	ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241
862967001134	Walker A/P-loop; other site
862967001135	ATP binding site [chemical binding]; other site
862967001136	Q-loop/lid; other site
862967001137	ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241
862967001138	ABC transporter signature motif; other site
862967001139	Walker B; other site
862967001140	D-loop; other site
862967001141	H-loop/switch region; other site
862967001142	phosphoprotein phosphatases of the metallophosphatase superfamily, metallophosphatase domain; Region: MPP_PPP_family; cd00144
862967001143	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
862967001144	active site
862967001145	metal binding site [ion binding]; metal-binding site
862967001146	ABC-type enterochelin transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: CeuA; COG4607
862967001147	Siderophore binding protein FatB.  These proteins have been shown to function as ABC-type initial receptors in the siderophore-mediated iron uptake in some eubacterial species.  They belong to the TroA superfamily of periplasmic metal binding proteins...; Region: FatB; cd01140
862967001148	putative ligand binding residues [chemical binding]; other site
862967001149	ABC-type enterochelin transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CeuD; COG4604
862967001150	ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214
862967001151	Walker A/P-loop; other site
862967001152	ATP binding site [chemical binding]; other site
862967001153	Q-loop/lid; other site
862967001154	ABC transporter signature motif; other site
862967001155	Walker B; other site
862967001156	D-loop; other site
862967001157	H-loop/switch region; other site
862967001158	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
862967001159	ABC-ATPase subunit  interface; other site
862967001160	dimer interface [polypeptide binding]; other site
862967001161	putative PBP binding regions; other site
862967001162	iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577
862967001163	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
862967001164	ABC-ATPase subunit  interface; other site
862967001165	dimer interface [polypeptide binding]; other site
862967001166	putative PBP binding regions; other site
862967001167	EDD domain protein, DegV family; Region: DegV; TIGR00762
862967001168	Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645
862967001169	Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591
862967001170	IHF dimer interface [polypeptide binding]; other site
862967001171	IHF - DNA interface [nucleotide binding]; other site
862967001172	Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153
862967001173	metal binding site 2 [ion binding]; metal-binding site
862967001174	putative DNA binding helix; other site
862967001175	metal binding site 1 [ion binding]; metal-binding site
862967001176	dimer interface [polypeptide binding]; other site
862967001177	structural Zn2+ binding site [ion binding]; other site
862967001178	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
862967001179	catalytic core [active]
862967001180	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
862967001181	Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768
862967001182	Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717
862967001183	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905
862967001184	recombination protein RecR; Reviewed; Region: recR; PRK00076
862967001185	RecR protein; Region: RecR; pfam02132
862967001186	TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR.  RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025
862967001187	putative active site [active]
862967001188	putative metal-binding site [ion binding]; other site
862967001189	tetramer interface [polypeptide binding]; other site
862967001190	D-alanyl-alanine synthetase A; Reviewed; Region: ddl; PRK01966
862967001191	D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820
862967001192	D-ala D-ala ligase C-terminus; Region: Dala_Dala_lig_C; pfam07478
862967001193	UDP-N-acetylmuramyl pentapeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurF; COG0770
862967001194	Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225
862967001195	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
862967001196	Protein of unknown function (DUF1697); Region: DUF1697; pfam08002
862967001197	Integral membrane protein (intg_mem_TP0381); Region: Intg_mem_TP0381; pfam09529
862967001198	Integral membrane protein (intg_mem_TP0381); Region: Intg_mem_TP0381; pfam09529
862967001199	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
862967001200	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
862967001201	non-specific DNA binding site [nucleotide binding]; other site
862967001202	salt bridge; other site
862967001203	sequence-specific DNA binding site [nucleotide binding]; other site
862967001204	peptide chain release factor 3; Provisional; Region: prfC; PRK00741
862967001205	Release Factor 3 (RF3) protein involved in the terminal step of translocation in bacteria; Region: RF3; cd04169
862967001206	G1 box; other site
862967001207	putative GEF interaction site [polypeptide binding]; other site
862967001208	GTP/Mg2+ binding site [chemical binding]; other site
862967001209	Switch I region; other site
862967001210	G2 box; other site
862967001211	G3 box; other site
862967001212	Switch II region; other site
862967001213	G4 box; other site
862967001214	G5 box; other site
862967001215	RF3_II: this subfamily represents the domain II of bacterial Release Factor 3 (RF3). Termination of protein synthesis by the ribosome requires two release factor (RF) classes. The class II RF3 is a GTPase that removes class I RFs (RF1 or RF2) from the...; Region: RF3_II; cd03689
862967001216	CorA-like Mg2+ transporter protein; Region: CorA; pfam01544
862967001217	uncharacterized bacterial subfamily of the Escherichia coli CorA-Salmonella typhimurium ZntB family; Region: EcCorA_ZntB-like_u2; cd12827
862967001218	Cl binding site [ion binding]; other site
862967001219	oligomer interface [polypeptide binding]; other site
862967001220	ATP-dependent RNA helicase SrmB; Provisional; Region: PRK11192
862967001221	DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker  B motif; Region: DEADc; cd00268
862967001222	ATP binding site [chemical binding]; other site
862967001223	Mg++ binding site [ion binding]; other site
862967001224	motif III; other site
862967001225	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
862967001226	nucleotide binding region [chemical binding]; other site
862967001227	ATP-binding site [chemical binding]; other site
862967001228	Class I aldolases; Region: Aldolase_Class_I; cl17187
862967001229	Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349
862967001230	helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420
862967001231	DeoR C terminal sensor domain; Region: DeoRC; pfam00455
862967001232	galactose-6-phosphate isomerase subunit LacB; Reviewed; Region: PRK08622
862967001233	Ribose/Galactose Isomerase; Region: LacAB_rpiB; cl00485
862967001234	PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211
862967001235	active site
862967001236	phosphorylation site [posttranslational modification]
862967001237	PTS_IIB_galactitol: subunit IIB of enzyme II (EII) of the galactitol-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS).  In this system, EII is a galactitol-specific permease with two cytoplasmic domains (IIA and IIB) and a...; Region: PTS_IIB_galactitol; cd05566
862967001238	active site
862967001239	P-loop; other site
862967001240	phosphorylation site [posttranslational modification]
862967001241	Phosphotransferase system, galactitol-specific IIC component [Carbohydrate transport and metabolism]; Region: GatC; COG3775
862967001242	PTS system sugar-specific permease component; Region: EIIC-GAT; pfam03611
862967001243	Fructose-1-phosphate kinase and related fructose-6-phosphate kinase (PfkB) [Carbohydrate transport and metabolism]; Region: FruK; COG1105
862967001244	ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase; Region: ribokinase_pfkB_like; cl00192
862967001245	substrate binding site [chemical binding]; other site
862967001246	ATP binding site [chemical binding]; other site
862967001247	Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837
862967001248	Beta-galactosidase/beta-glucuronidase [Carbohydrate transport and metabolism]; Region: LacZ; COG3250
862967001249	Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703
862967001250	Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836
862967001251	Bacterial Ig-like domain (group 4); Region: Big_4; pfam07532
862967001252	F5/8 type C domain; Region: F5_F8_type_C; pfam00754
862967001253	sugar binding site [chemical binding]; other site
862967001254	Glycosyl hydrolase family 20 (GH20) catalytic domain of dispersin B (DspB), lacto-N-biosidase (LnbB) and related proteins. Dispersin B is a soluble beta-N-acetylglucosamidase found in bacteria that hydrolyzes the beta-1,6-linkages of PGA (poly-beta-(1,6)...; Region: GH20_DspB_LnbB-like; cd06564
862967001255	Glycosyl hydrolase family 20, catalytic domain; Region: Glyco_hydro_20; pfam00728
862967001256	active site
862967001257	CAT RNA binding domain; Region: CAT_RBD; smart01061
862967001258	transcriptional antiterminator BglG; Provisional; Region: PRK09772
862967001259	PRD domain; Region: PRD; pfam00874
862967001260	PRD domain; Region: PRD; pfam00874
862967001261	PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_lac; cd00215
862967001262	methionine cluster; other site
862967001263	active site
862967001264	phosphorylation site [posttranslational modification]
862967001265	metal binding site [ion binding]; metal-binding site
862967001266	Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; cl17295
862967001267	Phosphotransferase system, EIIC; Region: PTS_EIIC; pfam02378
862967001268	PTS_IIB_lactose: subunit IIB of enzyme II (EII) of the lactose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS) found in Firmicutes as well as Actinobacteria. In this system, EII is a lactose-specific permease with two...; Region: PTS_IIB_lactose; cd05565
862967001269	active site
862967001270	P-loop; other site
862967001271	phosphorylation site [posttranslational modification]
862967001272	6-phospho-beta-galactosidase; Provisional; Region: PRK13511
862967001273	beta-galactosidase; Region: BGL; TIGR03356
862967001274	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1755
862967001275	The GIY-YIG domain of uncharacterized protein family UPF0213 related to structure-specific endonuclease SLX1; Region: GIY-YIG_UPF0213; cd10456
862967001276	GIY-YIG motif/motif A; other site
862967001277	putative active site [active]
862967001278	putative metal binding site [ion binding]; other site
862967001279	Predicted O-methyltransferase [General function prediction only]; Region: COG4123
862967001280	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
862967001281	S-adenosylmethionine binding site [chemical binding]; other site
862967001282	50S ribosomal protein L31 type B; Reviewed; Region: rpmE2; PRK01678
862967001283	Exopolyphosphatase-related proteins [General function prediction only]; Region: COG0618
862967001284	DHH family; Region: DHH; pfam01368
862967001285	flavodoxin; Validated; Region: PRK07308
862967001286	cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814; cl03223
862967001287	FeS assembly protein SufB; Region: sufB; TIGR01980
862967001288	Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628
862967001289	Domain of unknown function DUF20; Region: UPF0118; pfam01594
862967001290	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
862967001291	binding surface
862967001292	TPR motif; other site
862967001293	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429
862967001294	binding surface
862967001295	TPR motif; other site
862967001296	acetolactate synthase; Reviewed; Region: PRK08617
862967001297	Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035
862967001298	PYR/PP interface [polypeptide binding]; other site
862967001299	dimer interface [polypeptide binding]; other site
862967001300	TPP binding site [chemical binding]; other site
862967001301	Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205
862967001302	Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629
862967001303	TPP-binding site [chemical binding]; other site
862967001304	Alpha-acetolactate decarboxylase; Region: AAL_decarboxy; pfam03306
862967001305	Predicted RNA-binding protein homologous to eukaryotic snRNP [Transcription]; Region: COG1293
862967001306	Domain of unknown function (DUF814); Region: DUF814; pfam05670
862967001307	Type I periplasmic ligand-binding domain of uncharacterized ABC-type transport systems that are predicted to be involved in the uptake of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_uncharacterized_transporter; cd06325
862967001308	zinc binding site [ion binding]; other site
862967001309	putative ligand binding site [chemical binding]; other site
862967001310	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
862967001311	Transmembrane subunit (TM) of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which are involved in the uptake of branched-chain amino acids (AAs), as well as TMs of transporters involved in the uptake of...; Region: TM_PBP1_branched-chain-AA_like; cd06574
862967001312	TM-ABC transporter signature motif; other site
862967001313	ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: PhnK; COG1101
862967001314	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
862967001315	Walker A/P-loop; other site
862967001316	ATP binding site [chemical binding]; other site
862967001317	Q-loop/lid; other site
862967001318	ABC transporter signature motif; other site
862967001319	Walker B; other site
862967001320	D-loop; other site
862967001321	H-loop/switch region; other site
862967001322	Uncharacterized protein conserved in bacteria (DUF2128); Region: DUF2128; pfam09901
862967001323	Lipase.  Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is "interfacial activation", the process of...; Region: Lipase; cl14883
862967001324	nucleophilic elbow; other site
862967001325	catalytic triad; other site
862967001326	ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: COG4152
862967001327	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
862967001328	Walker A/P-loop; other site
862967001329	ATP binding site [chemical binding]; other site
862967001330	Q-loop/lid; other site
862967001331	ABC transporter signature motif; other site
862967001332	Walker B; other site
862967001333	D-loop; other site
862967001334	H-loop/switch region; other site
862967001335	Domain of unknown function (DUF4162); Region: DUF4162; pfam13732
862967001336	ABC-type Na+ efflux pump, permease component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatB; COG1668
862967001337	ATP-dependent nuclease subunit B; Region: rexB_recomb; TIGR02774
862967001338	PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705
862967001339	helicase-exonuclease AddAB, AddA subunit, Firmicutes type; Region: addA_Gpos; TIGR02785
862967001340	Family description; Region: UvrD_C_2; pfam13538
862967001341	Family description; Region: UvrD_C_2; pfam13538
862967001342	PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705
862967001343	glycogen branching enzyme; Provisional; Region: PRK12313
862967001344	N-terminal Early set domain associated with the catalytic domain of prokaryotic glycogen branching enzyme; Region: E_set_GBE_prok_N; cd02855
862967001345	Alpha amylase catalytic domain found in the Glycogen branching enzyme (also called 1,4-alpha-glucan branching enzyme); Region: AmyAc_Glg_BE; cd11322
862967001346	active site
862967001347	catalytic site [active]
862967001348	Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; pfam02806
862967001349	glucose-1-phosphate adenylyltransferase; Provisional; Region: glgC; PRK05293
862967001350	ADP-glucose pyrophosphorylase is involved in the biosynthesis of glycogen or starch; Region: ADP_Glucose_PP; cd02508
862967001351	ligand binding site; other site
862967001352	oligomer interface; other site
862967001353	Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651
862967001354	dimer interface [polypeptide binding]; other site
862967001355	N-terminal domain interface [polypeptide binding]; other site
862967001356	sulfate 1 binding site; other site
862967001357	glucose-1-phosphate adenylyltransferase, GlgD subunit; Region: glgD; TIGR02092
862967001358	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
862967001359	active site
862967001360	Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651
862967001361	dimer interface [polypeptide binding]; other site
862967001362	N-terminal domain interface [polypeptide binding]; other site
862967001363	sulfate 1 binding site; other site
862967001364	glycogen synthase; Provisional; Region: glgA; PRK00654
862967001365	This family is most closely related to the GT1 family of glycosyltransferases. Glycogen synthase catalyzes the formation and elongation of the alpha-1,4-glucose backbone using ADP-glucose, the second and key step of glycogen biosynthesis. This family...; Region: GT1_Glycogen_synthase_DULL1_like; cd03791
862967001366	ADP-binding pocket [chemical binding]; other site
862967001367	homodimer interface [polypeptide binding]; other site
862967001368	This is a family of oligosaccharide phosphorylases. It includes yeast and mammalian glycogen phosphorylases, plant starch/glucan phosphorylase, as well as the maltodextrin phosphorylases of bacteria. The members of this family catalyze the breakdown of...; Region: GT1_Glycogen_Phosphorylase; cd04300
862967001369	homodimer interface [polypeptide binding]; other site
862967001370	glycogen/starch/alpha-glucan phosphorylases; Region: P_ylase; TIGR02093
862967001371	active site pocket [active]
862967001372	F0F1 ATP synthase subunit C; Provisional; Region: PRK13467
862967001373	F0F1-type ATP synthase, subunit a [Energy production and conversion]; Region: AtpB; COG0356
862967001374	F0F1 ATP synthase subunit A; Validated; Region: PRK05815
862967001375	F0F1-type ATP synthase, subunit b [Energy production and conversion]; Region: AtpF; COG0711
862967001376	F0F1 ATP synthase subunit B; Validated; Region: PRK05759
862967001377	F0F1 ATP synthase subunit delta; Validated; Region: PRK05758
862967001378	ATP synthase delta (OSCP) subunit; Region: OSCP; pfam00213
862967001379	F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281
862967001380	ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874
862967001381	F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132
862967001382	beta subunit interaction interface [polypeptide binding]; other site
862967001383	Walker A motif; other site
862967001384	ATP binding site [chemical binding]; other site
862967001385	Walker B motif; other site
862967001386	ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306
862967001387	mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151
862967001388	core domain interface [polypeptide binding]; other site
862967001389	delta subunit interface [polypeptide binding]; other site
862967001390	epsilon subunit interface [polypeptide binding]; other site
862967001391	F0F1 ATP synthase subunit beta; Validated; Region: PRK09280
862967001392	ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874
862967001393	F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133
862967001394	alpha subunit interaction interface [polypeptide binding]; other site
862967001395	Walker A motif; other site
862967001396	ATP binding site [chemical binding]; other site
862967001397	Walker B motif; other site
862967001398	inhibitor binding site; inhibition site
862967001399	ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306
862967001400	F0F1 ATP synthase subunit epsilon; Validated; Region: atpC; PRK00571
862967001401	mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152
862967001402	gamma subunit interface [polypeptide binding]; other site
862967001403	epsilon subunit interface [polypeptide binding]; other site
862967001404	LBP interface [polypeptide binding]; other site
862967001405	Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198
862967001406	metal ion-dependent adhesion site (MIDAS); other site
862967001407	Cna protein B-type domain; Region: Cna_B; pfam05738
862967001408	fimbrial isopeptide formation D2 domain; Region: RrgB_K2N_iso_D2; TIGR04226
862967001409	Cna protein B-type domain; Region: Cna_B; pfam05738
862967001410	Sortase C (SrtC) or subfamily-3 sortases are membrane cysteine transpeptidases found in Gram-positive bacteria that anchor surface proteins to peptidoglycans of the bacterial cell wall envelope. This involves a transpeptidation reaction in which the...; Region: Sortase_C_3; cd05827
862967001411	active site
862967001412	catalytic site [active]
862967001413	UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072
862967001414	UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555
862967001415	hinge; other site
862967001416	active site
862967001417	DNA/RNA non-specific endonuclease; Region: Endonuclease_NS; smart00892
862967001418	DNA/RNA non-specific endonuclease; Region: Endonuclease_NS; pfam01223
862967001419	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
862967001420	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
862967001421	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
862967001422	Walker A/P-loop; other site
862967001423	ATP binding site [chemical binding]; other site
862967001424	Q-loop/lid; other site
862967001425	ABC transporter signature motif; other site
862967001426	Walker B; other site
862967001427	D-loop; other site
862967001428	H-loop/switch region; other site
862967001429	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
862967001430	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
862967001431	ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254
862967001432	Walker A/P-loop; other site
862967001433	ATP binding site [chemical binding]; other site
862967001434	Q-loop/lid; other site
862967001435	ABC transporter signature motif; other site
862967001436	Walker B; other site
862967001437	D-loop; other site
862967001438	H-loop/switch region; other site
862967001439	Uncharacterized conserved protein [Function unknown]; Region: COG1434
862967001440	YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259
862967001441	putative active site [active]
862967001442	LrgB-like family; Region: LrgB; pfam04172
862967001443	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
862967001444	active site
862967001445	Putative primosome component and related proteins [DNA replication, recombination, and repair]; Region: DnaD; COG3935
862967001446	Replication initiation and membrane attachment; Region: DnaB_2; pfam07261
862967001447	phosphoglucomutase-2-like protein; Provisional; Region: PTZ00150
862967001448	This CD includes PGM2 (phosphoglucomutase 2) and PGM2L1 (phosphoglucomutase 2-like 1). The mammalian PGM2 is thought to be a phosphopentomutase that catalyzes the conversion of the nucleoside breakdown products, ribose-1-phosphate and...; Region: PGM2; cd05799
862967001449	active site
862967001450	substrate binding site [chemical binding]; other site
862967001451	metal binding site [ion binding]; metal-binding site
862967001452	Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492
862967001453	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
862967001454	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
862967001455	Aminopeptidase N [Amino acid transport and metabolism]; Region: PepN; COG0308
862967001456	Peptidase M1 Aminopeptidase N family incudes tricorn interacting factor F3, Endoplasmic reticulum aminopeptidase 1 (ERAP1), Aminopeptidase Q (APQ); Region: M1_APN_2; cd09601
862967001457	Zn binding site [ion binding]; other site
862967001458	Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349
862967001459	DeoR-like helix-turn-helix domain; Region: HTH_DeoR; cl17531
862967001460	DeoR C terminal sensor domain; Region: DeoRC; pfam00455
862967001461	Fructose-1-phosphate kinase and related fructose-6-phosphate kinase (PfkB) [Carbohydrate transport and metabolism]; Region: FruK; COG1105
862967001462	1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164
862967001463	putative substrate binding site [chemical binding]; other site
862967001464	putative ATP binding site [chemical binding]; other site
862967001465	PTS system 2-O-a-mannosyl-D-glycerate specific transporter subunit IIABC; Provisional; Region: PRK09765
862967001466	PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211
862967001467	active site
862967001468	phosphorylation site [posttranslational modification]
862967001469	PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569
862967001470	active site
862967001471	P-loop; other site
862967001472	phosphorylation site [posttranslational modification]
862967001473	Phosphotransferase system, fructose-specific IIC component [Carbohydrate transport and metabolism]; Region: FruA; COG1299
862967001474	Protein of unknown function (DUF1149); Region: DUF1149; pfam06619
862967001475	EDD domain protein, DegV family; Region: DegV; TIGR00762
862967001476	Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645
862967001477	dihydrodipicolinate reductase; Provisional; Region: PRK00048
862967001478	Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113
862967001479	Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173
862967001480	tRNA CCA-pyrophosphorylase; Provisional; Region: PRK13299
862967001481	Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398
862967001482	active site
862967001483	NTP binding site [chemical binding]; other site
862967001484	metal binding triad [ion binding]; metal-binding site
862967001485	Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627
862967001486	tRNA nucleotidyltransferase domain 2 putative; Region: tRNA_NucTran2_2; pfam13735
862967001487	ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488
862967001488	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
862967001489	Walker A/P-loop; other site
862967001490	ATP binding site [chemical binding]; other site
862967001491	Q-loop/lid; other site
862967001492	ABC transporter signature motif; other site
862967001493	Walker B; other site
862967001494	D-loop; other site
862967001495	H-loop/switch region; other site
862967001496	ABC transporter; Region: ABC_tran_2; pfam12848
862967001497	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
862967001498	phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488
862967001499	Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912
862967001500	Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496
862967001501	dimer interface [polypeptide binding]; other site
862967001502	motif 1; other site
862967001503	active site
862967001504	motif 2; other site
862967001505	motif 3; other site
862967001506	Acetyltransferases [General function prediction only]; Region: RimI; COG0456
862967001507	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
862967001508	Coenzyme A binding pocket [chemical binding]; other site
862967001509	phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629
862967001510	tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain.  PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796
862967001511	putative tRNA-binding site [nucleotide binding]; other site
862967001512	B3/4 domain; Region: B3_4; pfam03483
862967001513	tRNA synthetase B5 domain; Region: B5; smart00874
862967001514	Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA,  PheRS is an...; Region: PheRS_beta_core; cd00769
862967001515	dimer interface [polypeptide binding]; other site
862967001516	motif 1; other site
862967001517	motif 3; other site
862967001518	motif 2; other site
862967001519	Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; smart00896
862967001520	BioY family; Region: BioY; pfam02632
862967001521	glutathione reductase; Validated; Region: PRK06116
862967001522	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
862967001523	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
862967001524	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
862967001525	Protein of unknown function (DUF3042); Region: DUF3042; pfam11240
862967001526	tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091
862967001527	tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324
862967001528	GTP-binding protein HflX; Region: GTP_HflX; TIGR03156
862967001529	GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167
862967001530	HflX GTPase family; Region: HflX; cd01878
862967001531	G1 box; other site
862967001532	GTP/Mg2+ binding site [chemical binding]; other site
862967001533	Switch I region; other site
862967001534	G2 box; other site
862967001535	G3 box; other site
862967001536	Switch II region; other site
862967001537	G4 box; other site
862967001538	G5 box; other site
862967001539	Galactose-1-phosphate uridyl transferase, N-terminal domain; Region: GalP_UDP_transf; pfam01087
862967001540	ribonuclease Z; Region: RNase_Z; TIGR02651
862967001541	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
862967001542	catalytic core [active]
862967001543	Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300
862967001544	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
862967001545	NAD(P) binding site [chemical binding]; other site
862967001546	active site
862967001547	Methyltransferase domain; Region: Methyltransf_23; pfam13489
862967001548	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
862967001549	S-adenosylmethionine binding site [chemical binding]; other site
862967001550	Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673
862967001551	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
862967001552	Coenzyme A binding pocket [chemical binding]; other site
862967001553	single-stranded-DNA-specific exonuclease RecJ; Region: recJ; TIGR00644
862967001554	DHH family; Region: DHH; pfam01368
862967001555	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4199
862967001556	DNA polymerase III DnaE; Reviewed; Region: dnaE; PRK07279
862967001557	Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III; Region: PHP_PolIIIA; cd07431
862967001558	active site
862967001559	PHP Thumb interface [polypeptide binding]; other site
862967001560	DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485
862967001561	generic binding surface II; other site
862967001562	generic binding surface I; other site
862967001563	Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to a subfamily of the PFKA family (cd00363) and include bacterial ATP-dependent...; Region: Bacterial_PFK; cd00763
862967001564	6-phosphofructokinase; Region: PFKA_ATP; TIGR02482
862967001565	active site
862967001566	ADP/pyrophosphate binding site [chemical binding]; other site
862967001567	dimerization interface [polypeptide binding]; other site
862967001568	allosteric effector site; other site
862967001569	fructose-1,6-bisphosphate binding site; other site
862967001570	pyruvate kinase; Provisional; Region: PRK05826
862967001571	Pyruvate kinase (PK):  Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342
862967001572	domain interfaces; other site
862967001573	active site
862967001574	signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227
862967001575	The S24, S26 LexA/signal peptidase superfamily contains LexA-related and type I signal peptidase families. The S24 LexA protein domains include: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC 3.4.21.88), the...; Region: Peptidase_S24_S26; cl10465
862967001576	The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530
862967001577	Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053
862967001578	Cation efflux family; Region: Cation_efflux; pfam01545
862967001579	ATP-dependent DNA helicase PcrA; Region: pcrA; TIGR01073
862967001580	Part of AAA domain; Region: AAA_19; pfam13245
862967001581	Family description; Region: UvrD_C_2; pfam13538
862967001582	Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447
862967001583	nudix motif; other site
862967001584	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
862967001585	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
862967001586	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
862967001587	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
862967001588	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
862967001589	Walker A/P-loop; other site
862967001590	ATP binding site [chemical binding]; other site
862967001591	Q-loop/lid; other site
862967001592	ABC transporter signature motif; other site
862967001593	Walker B; other site
862967001594	D-loop; other site
862967001595	H-loop/switch region; other site
862967001596	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
862967001597	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
862967001598	ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251
862967001599	Walker A/P-loop; other site
862967001600	ATP binding site [chemical binding]; other site
862967001601	Q-loop/lid; other site
862967001602	ABC transporter signature motif; other site
862967001603	Walker B; other site
862967001604	D-loop; other site
862967001605	H-loop/switch region; other site
862967001606	Predicted transcriptional regulators [Transcription]; Region: COG1510
862967001607	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
862967001608	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
862967001609	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4487
862967001610	Uncharacterized protein conserved in bacteria (DUF2130); Region: DUF2130; pfam09903
862967001611	Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673
862967001612	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
862967001613	Coenzyme A binding pocket [chemical binding]; other site
862967001614	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
862967001615	homoserine O-acetyltransferase; Provisional; Region: metX; cl17114
862967001616	tRNA pseudouridine synthase B; Provisional; Region: truB; PRK02484
862967001617	Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573
862967001618	RNA binding site [nucleotide binding]; other site
862967001619	active site
862967001620	tRNA Pseudouridine synthase II, C terminal; Region: TruB_C; pfam09142
862967001621	bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627
862967001622	FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064
862967001623	active site
862967001624	Riboflavin kinase; Region: Flavokinase; smart00904
862967001625	Arsenate Reductase (ArsC) family, Spx subfamily; Spx is a unique RNA polymerase (RNAP)-binding protein present in bacilli and some mollicutes. It inhibits transcription by binding to the C-terminal domain of the alpha subunit of RNAP, disrupting complex...; Region: ArsC_Spx; cd03032
862967001626	ArsC family; Region: ArsC; pfam03960
862967001627	putative catalytic residues [active]
862967001628	thiol/disulfide switch; other site
862967001629	hypothetical protein; Provisional; Region: PRK04387
862967001630	Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483
862967001631	Inositol-monophosphatase-like domains. This family of phosphatases is dependent on bivalent metal ions such as Mg++, and many members are inhibited by Li+ (which is thought to displace a bivalent ion in the active site). Substrates include fructose-1; Region: IMPase_like; cd01637
862967001632	active site
862967001633	rRNA (cytosine-C(5)-)-methyltransferase RsmF; Reviewed; Region: yebU; PRK11933
862967001634	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
862967001635	S-adenosylmethionine binding site [chemical binding]; other site
862967001636	pre-rRNA processing and ribosome biogenesis; Region: Nol1_Nop2_Fmu_2; pfam13636
862967001637	PBP superfamily domain; Region: PBP_like_2; cl17296
862967001638	ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstC; COG0573
862967001639	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
862967001640	dimer interface [polypeptide binding]; other site
862967001641	conserved gate region; other site
862967001642	putative PBP binding loops; other site
862967001643	ABC-ATPase subunit interface; other site
862967001644	ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstA; COG0581
862967001645	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
862967001646	dimer interface [polypeptide binding]; other site
862967001647	conserved gate region; other site
862967001648	putative PBP binding loops; other site
862967001649	ABC-ATPase subunit interface; other site
862967001650	phosphate transporter ATP-binding protein; Provisional; Region: PRK14237
862967001651	ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260
862967001652	Walker A/P-loop; other site
862967001653	ATP binding site [chemical binding]; other site
862967001654	Q-loop/lid; other site
862967001655	ABC transporter signature motif; other site
862967001656	Walker B; other site
862967001657	D-loop; other site
862967001658	H-loop/switch region; other site
862967001659	phosphate transporter ATP-binding protein; Provisional; Region: PRK14239
862967001660	ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260
862967001661	Walker A/P-loop; other site
862967001662	ATP binding site [chemical binding]; other site
862967001663	Q-loop/lid; other site
862967001664	ABC transporter signature motif; other site
862967001665	Walker B; other site
862967001666	D-loop; other site
862967001667	H-loop/switch region; other site
862967001668	phosphate transport system regulatory protein PhoU; Region: phoU_full; TIGR02135
862967001669	PhoU domain; Region: PhoU; pfam01895
862967001670	PhoU domain; Region: PhoU; pfam01895
862967001671	hypothetical protein; Reviewed; Region: PRK00024
862967001672	Nucleoporin autopeptidase; Region: Nucleoporin2; pfam04096
862967001673	Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071
862967001674	MPN+ (JAMM) motif; other site
862967001675	Zinc-binding site [ion binding]; other site
862967001676	redox-sensing transcriptional repressor Rex; Provisional; Region: PRK05472
862967001677	Putative DNA-binding protein N-terminus; Region: Put_DNA-bind_N; pfam06971
862967001678	CoA binding domain; Region: CoA_binding; pfam02629
862967001679	Putative amino acid metabolism; Region: DUF1831; pfam08866
862967001680	Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104
862967001681	cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402
862967001682	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
862967001683	catalytic residue [active]
862967001684	ribose-phosphate pyrophosphokinase; Provisional; Region: PRK02458
862967001685	N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793
862967001686	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
862967001687	active site
862967001688	Uncharacterized subgroup 1 of the CYTH-like superfamily; Region: CYTH-like_Pase_1; cd07762
862967001689	putative active site [active]
862967001690	putative metal binding residues [ion binding]; other site
862967001691	signature motif; other site
862967001692	putative triphosphate binding site [ion binding]; other site
862967001693	Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399
862967001694	synthetase active site [active]
862967001695	NTP binding site [chemical binding]; other site
862967001696	metal binding site [ion binding]; metal-binding site
862967001697	inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK04885
862967001698	ATP-NAD kinase; Region: NAD_kinase; pfam01513
862967001699	Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564
862967001700	Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869
862967001701	active site
862967001702	phosphotransacetylase; Reviewed; Region: eutD; PRK09653
862967001703	A/G-specific DNA glycosylase [DNA replication, recombination, and repair]; Region: MutY; COG1194
862967001704	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056
862967001705	minor groove reading motif; other site
862967001706	helix-hairpin-helix signature motif; other site
862967001707	substrate binding pocket [chemical binding]; other site
862967001708	active site
862967001709	DNA glycosylase (MutY in bacteria and hMYH in humans) is responsible for repairing misread  A*oxoG residues to C*G by removing the inappropriately paired adenine base from the DNA backbone. It belongs to the Nudix hydrolase superfamily and is important...; Region: DNA_Glycosylase_C; cd03431
862967001710	DNA binding and oxoG recognition site [nucleotide binding]
862967001711	TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947
862967001712	catalytic residues [active]
862967001713	Protein of unknown function (DUF1643); Region: DUF1643; pfam07799
862967001714	This CD includes PGM2 (phosphoglucomutase 2) and PGM2L1 (phosphoglucomutase 2-like 1). The mammalian PGM2 is thought to be a phosphopentomutase that catalyzes the conversion of the nucleoside breakdown products, ribose-1-phosphate and...; Region: PGM2; cd05799
862967001715	Phosphomannomutase [Carbohydrate transport and metabolism]; Region: {ManB}; COG1109
862967001716	active site
862967001717	substrate binding site [chemical binding]; other site
862967001718	metal binding site [ion binding]; metal-binding site
862967001719	Predicted membrane protein [Function unknown]; Region: COG4684
862967001720	Protein of unknown function (DUF3816); Region: DUF3816; pfam12822
862967001721	phosphopantothenoylcysteine decarboxylase; Validated; Region: PRK07313
862967001722	Flavoprotein; Region: Flavoprotein; pfam02441
862967001723	phosphopantothenate--cysteine ligase; Validated; Region: PRK06732
862967001724	formate--tetrahydrofolate ligase; Provisional; Region: PRK13505
862967001725	Formyltetrahydrofolate synthetase (FTHFS) catalyzes the ATP-dependent activation of formate ion via its addition to the N10 position of tetrahydrofolate. FTHFS is a highly expressed key enzyme in both the Wood-Ljungdahl pathway of autotrophic CO2...; Region: FTHFS; cd00477
862967001726	Potassium binding sites [ion binding]; other site
862967001727	Cesium cation binding sites [ion binding]; other site
862967001728	Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247
862967001729	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
862967001730	Coenzyme A binding pocket [chemical binding]; other site
862967001731	DNA alkylation repair enzyme; Region: DNA_alkylation; pfam08713
862967001732	A new structural DNA glycosylase containing HEAT-like repeats; Region: AlkD_like_1; cd07064
862967001733	active site
862967001734	Transcriptional regulator [Transcription]; Region: LysR; COG0583
862967001735	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
862967001736	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
862967001737	dimerization interface [polypeptide binding]; other site
862967001738	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
862967001739	non-specific DNA binding site [nucleotide binding]; other site
862967001740	salt bridge; other site
862967001741	sequence-specific DNA binding site [nucleotide binding]; other site
862967001742	malate dehydrogenase; Provisional; Region: PRK13529
862967001743	Malic enzyme, N-terminal domain; Region: malic; pfam00390
862967001744	NAD(P) binding domain of malic enzyme (ME), subgroup 1; Region: NAD_bind_1_malic_enz; cd05312
862967001745	NAD(P) binding site [chemical binding]; other site
862967001746	Membrane transport protein; Region: Mem_trans; cl09117
862967001747	Transposase DDE domain; Region: DDE_Tnp_1_3; pfam13612
862967001748	Lantibiotic dehydratase, N terminus; Region: Lant_dehyd_N; pfam04737
862967001749	Lantibiotic dehydratase, C terminus; Region: Lant_dehyd_C; pfam04738
862967001750	SpaB C-terminal domain; Region: SpaB_C; pfam14028
862967001751	Flavodoxin-like fold; Region: Flavodoxin_2; cl00438
862967001752	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
862967001753	LanC-like proteins. LanC is the cyclase enzyme of the lanthionine synthetase. Lanthionine is a lantibiotic, a unique class of peptide antibiotics. They are ribosomally synthesized as a precursor peptide and then post-translationally modified to contain...; Region: LanC_like; cl04955
862967001754	active site
862967001755	zinc binding site [ion binding]; other site
862967001756	ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122
862967001757	ATP-binding cassette domain of multidrug resistance protein-like transporters; Region: ABCC_MRP_Like; cd03228
862967001758	Walker A/P-loop; other site
862967001759	ATP binding site [chemical binding]; other site
862967001760	Q-loop/lid; other site
862967001761	ABC transporter signature motif; other site
862967001762	Walker B; other site
862967001763	D-loop; other site
862967001764	H-loop/switch region; other site
862967001765	CAAX protease self-immunity; Region: Abi; pfam02517
862967001766	Protein of unknown function (DUF1275); Region: DUF1275; pfam06912
862967001767	glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722
862967001768	Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479
862967001769	Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781
862967001770	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
862967001771	Major Facilitator Superfamily; Region: MFS_1; pfam07690
862967001772	putative substrate translocation pore; other site
862967001773	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
862967001774	Predicted membrane protein [Function unknown]; Region: COG3689
862967001775	Predicted permeases [General function prediction only]; Region: COG0701
862967001776	Transcriptional accessory protein [Transcription]; Region: Tex; COG2183
862967001777	Tex-like protein N-terminal domain; Region: Tex_N; pfam09371
862967001778	Likely ribonuclease with RNase H fold; Region: YqgFc; smart00732
862967001779	S1_Tex: The C-terminal S1 domain of a transcription accessory factor called Tex, which has been characterized in Bordetella pertussis and Pseudomonas aeruginosa. The tex gene is essential in Bortella pertusis and is named for its role in toxin expression; Region: S1_Tex; cd05685
862967001780	RNA binding site [nucleotide binding]; other site
862967001781	hypothetical protein; Provisional; Region: PRK04351
862967001782	SprT homologues; Region: SprT; cl01182
862967001783	Putative stress-responsive transcriptional regulator [Transcription / Signal transduction mechanisms]; Region: PspC; COG1983
862967001784	Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447
862967001785	nudix motif; other site
862967001786	HPr kinase/phosphorylase; Provisional; Region: PRK05428
862967001787	HPr Serine kinase N terminus; Region: Hpr_kinase_N; pfam02603
862967001788	HprK/P, the bifunctional histidine-containing protein kinase/phosphatase, controls the phosphorylation state of the phosphocarrier protein HPr and regulates the utilization of carbon sources by gram-positive bacteria. It catalyzes both the ATP-dependent...; Region: HprK_C; cd01918
862967001789	Hpr binding site; other site
862967001790	active site
862967001791	homohexamer subunit interaction site [polypeptide binding]; other site
862967001792	Prolipoprotein diacylglyceryl transferase; Region: LGT; pfam01790
862967001793	Uncharacterized protein containing a divergent version of the methyl-accepting chemotaxis-like domain [General function prediction only]; Region: COG4768
862967001794	YtxH-like protein; Region: YtxH; pfam12732
862967001795	Protein of unknown function (DUF3270); Region: DUF3270; pfam11674
862967001796	Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826
862967001797	Peptidase family U32; Region: Peptidase_U32; pfam01136
862967001798	Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826
862967001799	Peptidase family U32; Region: Peptidase_U32; pfam01136
862967001800	mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595
862967001801	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
862967001802	RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521
862967001803	Predicted esterase [General function prediction only]; Region: COG0627
862967001804	S-formylglutathione hydrolase; Region: PLN02442
862967001805	Zinc-dependent metalloprotease, MMP_like subfamily. This group contains matrix metalloproteinases (MMPs), serralysins, and the astacin_like family of proteases; Region: ZnMc_MMP_like; cd04268
862967001806	active site
862967001807	ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488
862967001808	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
862967001809	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
862967001810	ABC transporter; Region: ABC_tran_2; pfam12848
862967001811	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
862967001812	Type 1 glutamine amidotransferase (GATase1) domain found in Cobyric Acid Synthase (CobQ); Region: GATase1_CobQ; cd01750
862967001813	catalytic triad [active]
862967001814	UDP-N-acetylmuramyl tripeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurE; COG0769
862967001815	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
862967001816	Domain of unknown function (DUF1727); Region: DUF1727; pfam08353
862967001817	TIGR00159 family protein; Region: TIGR00159
862967001818	DisA bacterial checkpoint controller nucleotide-binding; Region: DisA_N; pfam02457
862967001819	YbbR-like protein; Region: YbbR; pfam07949
862967001820	YbbR-like protein; Region: YbbR; pfam07949
862967001821	phosphoglucosamine mutase; Provisional; Region: glmM; PRK14316
862967001822	GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802
862967001823	active site
862967001824	substrate binding site [chemical binding]; other site
862967001825	metal binding site [ion binding]; metal-binding site
862967001826	phosphoserine phosphatase SerB; Region: serB; TIGR00338
862967001827	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
862967001828	motif II; other site
862967001829	glycerate kinase; Region: TIGR00045
862967001830	Ferredoxin [Energy production and conversion]; Region: Fer; COG1141
862967001831	cytidylate kinase; Provisional; Region: cmk; PRK00023
862967001832	Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020
862967001833	CMP-binding site; other site
862967001834	The sites determining sugar specificity; other site
862967001835	translation initiation factor IF-3; Reviewed; Region: infC; PRK00028
862967001836	Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198
862967001837	Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707
862967001838	50S ribosomal protein L35; Reviewed; Region: rpmI; PRK00172
862967001839	Ribosomal protein L20; Region: Ribosomal_L20; cd07026
862967001840	23S rRNA binding site [nucleotide binding]; other site
862967001841	L21 binding site [polypeptide binding]; other site
862967001842	L13 binding site [polypeptide binding]; other site
862967001843	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
862967001844	Glyoxalase I catalyzes the isomerization of the hemithioacetal, formed by a 2-oxoaldehyde and glutathione, to S-D-lactoylglutathione; Region: Glyoxalase_I; cd07233
862967001845	dimer interface [polypeptide binding]; other site
862967001846	active site
862967001847	metal binding site [ion binding]; metal-binding site
862967001848	glutathione binding site [chemical binding]; other site
862967001849	Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726
862967001850	Catalytic NodB homology domain of Streptococcus pneumoniae peptidoglycan deacetylase PgdA, Bacillus subtilis BsYjeA protein, and their bacterial homologs; Region: CE4_SpPgdA_BsYjeA_like; cd10947
862967001851	NodB motif; other site
862967001852	active site
862967001853	catalytic site [active]
862967001854	Zn binding site [ion binding]; other site
862967001855	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251
862967001856	DEAD-like helicases superfamily; Region: DEXDc; smart00487
862967001857	ATP binding site [chemical binding]; other site
862967001858	putative Mg++ binding site [ion binding]; other site
862967001859	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
862967001860	nucleotide binding region [chemical binding]; other site
862967001861	ATP-binding site [chemical binding]; other site
862967001862	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
862967001863	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
862967001864	Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894
862967001865	Uridine kinase [Nucleotide transport and metabolism]; Region: Udk; COG0572
862967001866	Uridine monophosphate kinase (UMPK, EC 2.7.1.48), also known as uridine kinase or uridine-cytidine kinase (UCK), catalyzes the reversible phosphoryl transfer from ATP to uridine or cytidine to yield UMP or CMP. In the primidine nucleotide-salvage pathway; Region: UMPK; cd02023
862967001867	Sugar specificity; other site
862967001868	Pyrimidine base specificity; other site
862967001869	ATP-binding site [chemical binding]; other site
862967001870	peptidase T; Region: peptidase-T; TIGR01882
862967001871	M20 Peptidase T specifically cleaves tripeptides; Region: M20_peptT; cd03892
862967001872	metal binding site [ion binding]; metal-binding site
862967001873	dimer interface [polypeptide binding]; other site
862967001874	Protoheme ferro-lyase (ferrochelatase) [Coenzyme metabolism]; Region: HemH; COG0276
862967001875	Class II Chelatase: a family of ATP-independent monomeric or homodimeric enzymes that catalyze the insertion of metal into protoporphyrin rings. This family includes protoporphyrin IX ferrochelatase (HemH), sirohydrochlorin ferrochelatase (SirB) and the...; Region: Chelatase_Class_II; cl02784
862967001876	active site
862967001877	Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419
862967001878	active site
862967001879	N-terminal domain interface [polypeptide binding]; other site
862967001880	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
862967001881	haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282
862967001882	active site
862967001883	motif I; other site
862967001884	motif II; other site
862967001885	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
862967001886	motif II; other site
862967001887	GTP-binding protein LepA; Provisional; Region: PRK05433
862967001888	LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890
862967001889	G1 box; other site
862967001890	putative GEF interaction site [polypeptide binding]; other site
862967001891	GTP/Mg2+ binding site [chemical binding]; other site
862967001892	Switch I region; other site
862967001893	G2 box; other site
862967001894	G3 box; other site
862967001895	Switch II region; other site
862967001896	G4 box; other site
862967001897	G5 box; other site
862967001898	lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699
862967001899	lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane.   LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709
862967001900	GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421
862967001901	UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK13905
862967001902	FAD binding domain; Region: FAD_binding_4; pfam01565
862967001903	UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873
862967001904	ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842
862967001905	ATP-binding cassette domain of the polyamine transporter; Region: ABC_PotA_N; cd03300
862967001906	Walker A/P-loop; other site
862967001907	ATP binding site [chemical binding]; other site
862967001908	Q-loop/lid; other site
862967001909	ABC transporter signature motif; other site
862967001910	Walker B; other site
862967001911	D-loop; other site
862967001912	H-loop/switch region; other site
862967001913	TOBE domain; Region: TOBE_2; pfam08402
862967001914	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
862967001915	dimer interface [polypeptide binding]; other site
862967001916	conserved gate region; other site
862967001917	putative PBP binding loops; other site
862967001918	ABC-ATPase subunit interface; other site
862967001919	ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177
862967001920	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
862967001921	dimer interface [polypeptide binding]; other site
862967001922	conserved gate region; other site
862967001923	putative PBP binding loops; other site
862967001924	ABC-ATPase subunit interface; other site
862967001925	Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687
862967001926	Bacterial extracellular solute-binding protein; Region: SBP_bac_6; pfam13343
862967001927	aspartate-semialdehyde dehydrogenase; Provisional; Region: PRK14874
862967001928	Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859
862967001929	Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950
862967001930	Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329
862967001931	dimer interface [polypeptide binding]; other site
862967001932	active site
862967001933	catalytic residue [active]
862967001934	A predicted NlpC/p60-like peptidase; Region: BtrH; pfam14399
862967001935	Helix-turn-helix domain; Region: HTH_18; pfam12833
862967001936	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
862967001937	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3708
862967001938	Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797
862967001939	23S rRNA interface [nucleotide binding]; other site
862967001940	Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site
862967001941	Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387
862967001942	core dimer interface [polypeptide binding]; other site
862967001943	L10 interface [polypeptide binding]; other site
862967001944	L11 interface [polypeptide binding]; other site
862967001945	putative EF-Tu interaction site [polypeptide binding]; other site
862967001946	putative EF-G interaction site [polypeptide binding]; other site
862967001947	Radical SAM superfamily; Region: Radical_SAM; pfam04055
862967001948	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
862967001949	FeS/SAM binding site; other site
862967001950	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
862967001951	ATP-binding cassette domain of multidrug resistance protein-like transporters; Region: ABCC_MRP_Like; cd03228
862967001952	Walker A/P-loop; other site
862967001953	ATP binding site [chemical binding]; other site
862967001954	Q-loop/lid; other site
862967001955	ABC transporter signature motif; other site
862967001956	Walker B; other site
862967001957	D-loop; other site
862967001958	H-loop/switch region; other site
862967001959	16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK00122
862967001960	RimM N-terminal domain; Region: RimM; pfam01782
862967001961	PRC-barrel domain; Region: PRC; pfam05239
862967001962	tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026
862967001963	ABC-type metal ion transport system, periplasmic component/surface adhesin [Inorganic ion transport and metabolism]; Region: LraI; COG0803
862967001964	Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+.  Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262
862967001965	intersubunit interface [polypeptide binding]; other site
862967001966	streptococcal histidine triad protein; Region: strep_his_triad; TIGR01363
862967001967	Streptococcal histidine triad protein; Region: Strep_his_triad; pfam04270
862967001968	Streptococcal histidine triad protein; Region: Strep_his_triad; pfam04270
862967001969	Streptococcal histidine triad protein; Region: Strep_his_triad; pfam04270
862967001970	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
862967001971	S-adenosylmethionine binding site [chemical binding]; other site
862967001972	GAF domain-containing protein [Signal transduction mechanisms]; Region: COG1956
862967001973	GAF domain; Region: GAF_2; pfam13185
862967001974	DNA polymerase III subunits gamma and tau; Validated; Region: PRK05563
862967001975	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
862967001976	Walker A motif; other site
862967001977	ATP binding site [chemical binding]; other site
862967001978	Walker B motif; other site
862967001979	arginine finger; other site
862967001980	DNA polymerase III subunits gamma and tau domain III; Region: DNA_pol3_gamma3; pfam12169
862967001981	Predicted glutamine amidotransferases [General function prediction only]; Region: COG2071
862967001982	Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_2; cd01745
862967001983	catalytic triad [active]
862967001984	Amino acid permease; Region: AA_permease; pfam00324
862967001985	YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448
862967001986	homotrimer interaction site [polypeptide binding]; other site
862967001987	putative active site [active]
862967001988	Cystathionine beta-lyases/cystathionine gamma-synthases [Amino acid transport and metabolism]; Region: MetC; COG0626
862967001989	CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614
862967001990	homodimer interface [polypeptide binding]; other site
862967001991	substrate-cofactor binding pocket; other site
862967001992	pyridoxal 5'-phosphate binding site [chemical binding]; other site
862967001993	catalytic residue [active]
862967001994	dipeptidase PepV; Reviewed; Region: PRK07318
862967001995	M20 Peptidase Xaa-His dipeptidase (PepV) degrades hydrophobic dipeptides; Region: M20_PepV; cd03888
862967001996	active site
862967001997	metal binding site [ion binding]; metal-binding site
862967001998	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2964
862967001999	YheO-like PAS domain; Region: PAS_6; pfam08348
862967002000	HTH domain; Region: HTH_22; pfam13309
862967002001	Predicted membrane protein [Function unknown]; Region: COG2860
862967002002	UPF0126 domain; Region: UPF0126; pfam03458
862967002003	UPF0126 domain; Region: UPF0126; pfam03458
862967002004	Protein of unknown function (DUF3272); Region: DUF3272; pfam11676
862967002005	bifunctional biotin--[acetyl-CoA-carboxylase] synthetase/biotin operon repressor; Provisional; Region: PRK11886
862967002006	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
862967002007	DNA-binding site [nucleotide binding]; DNA binding site
862967002008	Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; pfam03099
862967002009	Biotin protein ligase C terminal domain; Region: BPL_C; pfam02237
862967002010	DNA-binding transcriptional repressor EbgR; Provisional; Region: PRK10339
862967002011	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
862967002012	DNA binding site [nucleotide binding]
862967002013	Ligand-binding domain of DNA transcription repressor GalR which is one of two regulatory proteins involved in galactose transport and metabolism; Region: PBP1_GalR; cd01544
862967002014	putative ligand binding site [chemical binding]; other site
862967002015	putative dimerization interface [polypeptide binding]; other site
862967002016	galactokinase; Provisional; Region: PRK05322
862967002017	Galactokinase galactose-binding signature; Region: GalKase_gal_bdg; pfam10509
862967002018	GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288
862967002019	GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544
862967002020	beta-phosphoglucomutase family hydrolase; Region: PGMB-YQAB-SF; TIGR02009
862967002021	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
862967002022	motif II; other site
862967002023	galactose-1-phosphate uridylyltransferase; Provisional; Region: PRK05270
862967002024	Galactose-1-phosphate uridyl transferase, N-terminal domain; Region: GalP_UDP_transf; pfam01087
862967002025	Galactose-1-phosphate uridyl transferase, C-terminal domain; Region: GalP_UDP_tr_C; pfam02744
862967002026	GTPase CgtA; Reviewed; Region: obgE; PRK12297
862967002027	GTP1/OBG; Region: GTP1_OBG; pfam01018
862967002028	Obg GTPase; Region: Obg; cd01898
862967002029	G1 box; other site
862967002030	GTP/Mg2+ binding site [chemical binding]; other site
862967002031	Switch I region; other site
862967002032	G2 box; other site
862967002033	G3 box; other site
862967002034	Switch II region; other site
862967002035	G4 box; other site
862967002036	G5 box; other site
862967002037	Domain of unknown function (DUF1967); Region: DUF1967; pfam09269
862967002038	Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726
862967002039	Putative catalytic NodB homology domain of PgaB, IcaB, and similar proteins which consist of a deformed (beta/alpha)8 barrel fold with 5- or 6-strands; Region: CE4_NodB_like_5s_6s; cd10918
862967002040	putative active site [active]
862967002041	putative metal binding site [ion binding]; other site
862967002042	homoserine dehydrogenase; Provisional; Region: PRK06349
862967002043	Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447
862967002044	Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742
862967002045	ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141
862967002046	homoserine kinase; Provisional; Region: PRK01212
862967002047	GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288
862967002048	GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544
862967002049	Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455
862967002050	Alpha/beta hydrolase of unknown function (DUF915); Region: DUF915; pfam06028
862967002051	Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; pfam04313
862967002052	DEAD-like helicases superfamily; Region: DEXDc; smart00487
862967002053	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
862967002054	ATP binding site [chemical binding]; other site
862967002055	putative Mg++ binding site [ion binding]; other site
862967002056	Type I restriction and modification enzyme - subunit R C terminal; Region: EcoR124_C; pfam12008
862967002057	Domain of unknown function (DUF1837); Region: DUF1837; pfam08878
862967002058	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
862967002059	ATP binding site [chemical binding]; other site
862967002060	putative Mg++ binding site [ion binding]; other site
862967002061	helicase superfamily c-terminal domain; Region: HELICc; smart00490
862967002062	Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732
862967002063	Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420
862967002064	Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420
862967002065	Protein involved in cell division [Cell division and chromosome partitioning]; Region: Fic; COG2184
862967002066	Fic/DOC family; Region: Fic; cl00960
862967002067	HsdM N-terminal domain; Region: HsdM_N; pfam12161
862967002068	N-6 DNA Methylase; Region: N6_Mtase; pfam02384
862967002069	Methyltransferase domain; Region: Methyltransf_26; pfam13659
862967002070	Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732
862967002071	Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420
862967002072	Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582
862967002073	phiLC3 phage and phage-related integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes various bacterial (mainly gram positive) and phage integrases, including those similar to Lactococcus...; Region: INT_phiLC3_C; cd01189
862967002074	Int/Topo IB signature motif; other site
862967002075	Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732
862967002076	Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420
862967002077	Transcriptional regulator [Transcription]; Region: LysR; COG0583
862967002078	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
862967002079	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
862967002080	benzoate transport; Region: 2A0115; TIGR00895
862967002081	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
862967002082	putative substrate translocation pore; other site
862967002083	Transcriptional regulator [Transcription]; Region: LysR; COG0583
862967002084	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
862967002085	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
862967002086	dimerization interface [polypeptide binding]; other site
862967002087	dihydroorotate dehydrogenase electron transfer subunit; Reviewed; Region: PRK00054
862967002088	FAD/NAD binding domain in the electron transfer subunit of dihydroorotate dehydrogenase. Dihydroorotate dehydrogenases (DHODs) catalyze the only redox reaction in pyrimidine de novo biosynthesis. They catalyze the oxidation of (S)-dihydroorotate to...; Region: DHOD_e_trans; cd06218
862967002089	FAD binding pocket [chemical binding]; other site
862967002090	FAD binding motif [chemical binding]; other site
862967002091	phosphate binding motif [ion binding]; other site
862967002092	beta-alpha-beta structure motif; other site
862967002093	NAD binding pocket [chemical binding]; other site
862967002094	Iron coordination center [ion binding]; other site
862967002095	dihydroorotate dehydrogenase (subfamily 1) family protein; Region: pyrD_sub1_fam; TIGR01037
862967002096	Dihydroorotate dehydrogenase (DHOD) class 1B FMN-binding domain. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine...; Region: DHOD_1B_like; cd04740
862967002097	heterodimer interface [polypeptide binding]; other site
862967002098	active site
862967002099	FMN binding site [chemical binding]; other site
862967002100	homodimer interface [polypeptide binding]; other site
862967002101	substrate binding site [chemical binding]; other site
862967002102	Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725
862967002103	active site
862967002104	dimer interface [polypeptide binding]; other site
862967002105	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
862967002106	active site
862967002107	hypothetical protein; Provisional; Region: PRK13672
862967002108	Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702
862967002109	PhoH-like protein; Region: PhoH; pfam02562
862967002110	Protein of unknown function (DUF3781); Region: DUF3781; pfam12636
862967002111	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
862967002112	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
862967002113	Coenzyme A binding pocket [chemical binding]; other site
862967002114	Regulator of competence-specific genes [Transcription]; Region: TfoX; COG3070
862967002115	Alanine dehydrogenase [Amino acid transport and metabolism]; Region: Ald; COG0686
862967002116	Alanine dehydrogenase NAD-binding and catalytic domains; Region: L-AlaDH; cd05305
862967002117	hexamer interface [polypeptide binding]; other site
862967002118	ligand binding site [chemical binding]; other site
862967002119	putative active site [active]
862967002120	NAD(P) binding site [chemical binding]; other site
862967002121	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
862967002122	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
862967002123	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
862967002124	Walker A/P-loop; other site
862967002125	ATP binding site [chemical binding]; other site
862967002126	Q-loop/lid; other site
862967002127	ABC transporter signature motif; other site
862967002128	Walker B; other site
862967002129	D-loop; other site
862967002130	H-loop/switch region; other site
862967002131	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
862967002132	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
862967002133	ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254
862967002134	Walker A/P-loop; other site
862967002135	ATP binding site [chemical binding]; other site
862967002136	Q-loop/lid; other site
862967002137	ABC transporter signature motif; other site
862967002138	Walker B; other site
862967002139	D-loop; other site
862967002140	H-loop/switch region; other site
862967002141	metal-binding heat shock protein; Provisional; Region: PRK00016
862967002142	Diacylglycerol kinase [Cell envelope biogenesis, outer membrane]; Region: DgkA; COG0818
862967002143	GTPase Era; Reviewed; Region: era; PRK00089
862967002144	E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163
862967002145	G1 box; other site
862967002146	GTP/Mg2+ binding site [chemical binding]; other site
862967002147	Switch I region; other site
862967002148	G2 box; other site
862967002149	Switch II region; other site
862967002150	G3 box; other site
862967002151	G4 box; other site
862967002152	G5 box; other site
862967002153	KH domain; Region: KH_2; pfam07650
862967002154	Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_18; cd04677
862967002155	nudix motif; other site
862967002156	formamidopyrimidine/5-formyluracil/ 5-hydroxymethyluracil DNA glycosylase; Validated; Region: PRK01103
862967002157	N-terminal domain of Escherichia coli Fpg1/MutM and related bacterial DNA glycosylases; Region: EcFpg-like_N; cd08966
862967002158	DNA binding site [nucleotide binding]
862967002159	catalytic residue [active]
862967002160	H2TH interface [polypeptide binding]; other site
862967002161	putative catalytic residues [active]
862967002162	turnover-facilitating residue; other site
862967002163	intercalation triad [nucleotide binding]; other site
862967002164	8OG recognition residue [nucleotide binding]; other site
862967002165	putative reading head residues; other site
862967002166	Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831
862967002167	Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827
862967002168	Dephospho-CoA kinase [Coenzyme metabolism]; Region: CoaE; COG0237
862967002169	Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022
862967002170	CoA-binding site [chemical binding]; other site
862967002171	ATP-binding [chemical binding]; other site
862967002172	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
862967002173	putative substrate translocation pore; other site
862967002174	50S ribosomal protein L33; Validated; Region: rpmG; PRK00595
862967002175	Preprotein translocase subunit SecG [Intracellular trafficking and secretion]; Region: SecG; COG1314
862967002176	ribonuclease R; Region: RNase_R; TIGR02063
862967002177	Ribonuclease B OB domain; Region: OB_RNB; pfam08206
862967002178	RNB domain; Region: RNB; pfam00773
862967002179	S1_RNase_R: RNase R C-terminal S1 domain. RNase R is a processive 3' to 5' exoribonuclease, which is a homolog of RNase II. RNase R degrades RNA with secondary structure having a 3' overhang of at least 7 nucleotides. RNase R and PNPase...; Region: S1_RNase_R; cd04471
862967002180	RNA binding site [nucleotide binding]; other site
862967002181	Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294
862967002182	SmpB-tmRNA interface; other site
862967002183	SLBB domain; Region: SLBB; pfam10531
862967002184	comEA protein; Region: comE; TIGR01259
862967002185	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cl14786
862967002186	Predicted membrane metal-binding protein [General function prediction only]; Region: ComEC; COG0658
862967002187	Domain of unknown function (DUF4131); Region: DUF4131; pfam13567
862967002188	Competence protein; Region: Competence; pfam03772
862967002189	Predicted hydrolase (metallo-beta-lactamase superfamily) [General function prediction only]; Region: ComEC; COG2333
862967002190	Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446
862967002191	Predicted membrane protein [Function unknown]; Region: COG3152
862967002192	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
862967002193	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
862967002194	Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894
862967002195	Family 1 of Uracil-DNA glycosylase (UDG) enzymes; Region: UDG_F1; cd10027
862967002196	ligand binding site [chemical binding]; other site
862967002197	active site
862967002198	UGI interface [polypeptide binding]; other site
862967002199	catalytic site [active]
862967002200	MutT homolog-1 (MTH1) is a member of the Nudix hydrolase superfamily. MTH1, the mammalian counterpart of MutT, hydrolyzes oxidized purine nucleoside triphosphates, such as 8-oxo-dGTP and 2-hydroxy-ATP, to monophosphates, thereby preventing the...; Region: MTH1; cd03427
862967002201	putative active site [active]
862967002202	nucleotide binding site [chemical binding]; other site
862967002203	nudix motif; other site
862967002204	putative metal binding site [ion binding]; other site
862967002205	dihydroorotase; Validated; Region: pyrC; PRK09357
862967002206	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
862967002207	Dihydroorotase (DHOase), subgroup IIa; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This subgroup also contains proteins that lack the active site, like unc-33, a C; Region: DHOase_IIa; cd01317
862967002208	active site
862967002209	S-adenosylmethionine synthetase; Validated; Region: PRK05250
862967002210	S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438
862967002211	S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772
862967002212	S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773
862967002213	UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072
862967002214	UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555
862967002215	hinge; other site
862967002216	active site
862967002217	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
862967002218	Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583
862967002219	Predicted transcriptional regulator containing CBS domains [Transcription]; Region: COG4109
862967002220	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
862967002221	DNA-binding site [nucleotide binding]; DNA binding site
862967002222	DRTGG domain; Region: DRTGG; pfam07085
862967002223	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with a DRTGG domain upstream. The function of the DRTGG domain, named after its conserved residues, is unknown. CBS is a small domain originally...; Region: CBS_pair_DRTGG_assoc; cd04596
862967002224	The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cd03440
862967002225	active site 2 [active]
862967002226	active site 1 [active]
862967002227	Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086
862967002228	active site
862967002229	Ribonuclease BN family enzyme [Replication, recombination, and repair]; Region: Rbn; COG1295
862967002230	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
862967002231	MarR family; Region: MarR; pfam01047
862967002232	Solo B3/4 domain (OB-fold DNA/RNA-binding) of Phe-aaRS-beta [General function prediction only]; Region: COG3382
862967002233	B3/4 domain; Region: B3_4; pfam03483
862967002234	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963
862967002235	Integrase core domain; Region: rve; pfam00665
862967002236	Integrase core domain; Region: rve_2; pfam13333
862967002237	Predicted membrane protein [Function unknown]; Region: COG2246
862967002238	GtrA-like protein; Region: GtrA; pfam04138
862967002239	Predicted membrane protein [Function unknown]; Region: COG4708
862967002240	Predicted membrane protein, putative toxin regulator [General function prediction only]; Region: PfoR; COG3641
862967002241	Phosphotransferase system, EIIC; Region: PTS_EIIC_2; pfam13303
862967002242	2-dehydropantoate 2-reductase; Reviewed; Region: PRK06522
862967002243	Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558
862967002244	Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546
862967002245	NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956
862967002246	NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114
862967002247	nucleotide binding pocket [chemical binding]; other site
862967002248	K-X-D-G motif; other site
862967002249	catalytic site [active]
862967002250	NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120
862967002251	NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119
862967002252	Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027
862967002253	Dimer interface [polypeptide binding]; other site
862967002254	BRCT sequence motif; other site
862967002255	putative lipid kinase; Reviewed; Region: PRK13055
862967002256	Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781
862967002257	Family 41 Carbohydrate-Binding Module from pullulanase-like enzymes; Region: CBM41_pullulanase; cd10315
862967002258	carbohydrate binding site [chemical binding]; other site
862967002259	pullulanase, type I; Region: pulA_typeI; TIGR02104
862967002260	Early set domain associated with the catalytic domain of pullulanase (also called dextrinase and alpha-dextrin endo-1,6-alpha glucosidase); Region: E_set_Pullulanase; cd02860
862967002261	Alpha amylase catalytic domain found in Pullulanase (also called dextrinase; alpha-dextrin endo-1,6-alpha glucosidase), limit dextrinase, and related proteins; Region: AmyAc_Pullulanase_LD-like; cd11341
862967002262	Ca binding site [ion binding]; other site
862967002263	active site
862967002264	catalytic site [active]
862967002265	Ribosomal protein S16 [Translation, ribosomal structure and biogenesis]; Region: RpsP; COG0228
862967002266	Predicted RNA-binding protein (contains KH domain) [General function prediction only]; Region: COG1837
862967002267	KH domain; Region: KH_4; pfam13083
862967002268	G-X-X-G motif; other site
862967002269	Predicted small molecule binding protein (contains 3H domain) [General function prediction only]; Region: COG1827
862967002270	HTH domain; Region: HTH_11; pfam08279
862967002271	3H domain; Region: 3H; pfam02829
862967002272	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
862967002273	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
862967002274	Uncharacterized protein involved in copper resistance [Inorganic ion transport and metabolism]; Region: CutC; COG3142
862967002275	Protein of unknown function (DUF419); Region: DUF419; cl15265
862967002276	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
862967002277	putative multidrug transporter membrane\ATP-binding components; Provisional; Region: PRK10789
862967002278	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
862967002279	Walker A/P-loop; other site
862967002280	ATP binding site [chemical binding]; other site
862967002281	Q-loop/lid; other site
862967002282	ABC transporter signature motif; other site
862967002283	Walker B; other site
862967002284	D-loop; other site
862967002285	H-loop/switch region; other site
862967002286	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
862967002287	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
862967002288	ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254
862967002289	Walker A/P-loop; other site
862967002290	ATP binding site [chemical binding]; other site
862967002291	Q-loop/lid; other site
862967002292	ABC transporter signature motif; other site
862967002293	Walker B; other site
862967002294	D-loop; other site
862967002295	H-loop/switch region; other site
862967002296	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167
862967002297	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
862967002298	DNA-binding site [nucleotide binding]; DNA binding site
862967002299	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
862967002300	pyridoxal 5'-phosphate binding site [chemical binding]; other site
862967002301	homodimer interface [polypeptide binding]; other site
862967002302	catalytic residue [active]
862967002303	CRISPR/Cas system-associated protein Cas9; Region: Csn1; cd09643
862967002304	CRISPR-associated protein Cas9/Csn1, subtype II/NMEMI; Region: cas_Csn1; TIGR01865
862967002305	CRISPR/Cas system-associated protein Cas1; Region: Cas1_II; cd09720
862967002306	CRISPR/Cas system-associated protein Cas2; Region: Cas2_I_II_III; cd09638
862967002307	Stu0660-like CRISPR/Cas system-associated protein Csn2; Region: Stu0660_Csn2; cd12217
862967002308	tetramer interface [polypeptide binding]; other site
862967002309	putative DNA binding site [nucleotide binding]; other site
862967002310	Cysteine-rich secretory protein family; Region: CAP; pfam00188
862967002311	ATP cone domain; Region: ATP-cone; pfam03477
862967002312	30S ribosomal protein S21; Reviewed; Region: rpsU; PRK00270
862967002313	GTPase YlqF; Reviewed; Region: rbgA; PRK09563
862967002314	Circularly permuted YlqF GTPase; Region: YlqF; cd01856
862967002315	GTP/Mg2+ binding site [chemical binding]; other site
862967002316	G4 box; other site
862967002317	G5 box; other site
862967002318	G1 box; other site
862967002319	Switch I region; other site
862967002320	G2 box; other site
862967002321	G3 box; other site
862967002322	Switch II region; other site
862967002323	bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182
862967002324	RNA/DNA hybrid binding site [nucleotide binding]; other site
862967002325	active site
862967002326	maltose O-acetyltransferase; Provisional; Region: PRK10092
862967002327	Maltose O-acetyltransferase (MAT) and Galactoside O-acetyltransferase (GAT): MAT and GAT catalyze the CoA-dependent acetylation of the 6-hydroxyl group of their respective sugar substrates. MAT acetylates maltose and glucose exclusively at the C6...; Region: LbH_MAT_GAT; cd03357
862967002328	active site
862967002329	substrate binding site [chemical binding]; other site
862967002330	trimer interface [polypeptide binding]; other site
862967002331	CoA binding site [chemical binding]; other site
862967002332	DNA recombination-mediator protein A; Region: DNA_processg_A; pfam02481
862967002333	DNA protecting protein DprA; Region: dprA; TIGR00732
862967002334	DNA topoisomerase I; Validated; Region: PRK05582
862967002335	TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I.   Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363
862967002336	active site
862967002337	interdomain interaction site; other site
862967002338	putative metal-binding site [ion binding]; other site
862967002339	nucleotide binding site [chemical binding]; other site
862967002340	DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186
862967002341	domain I; other site
862967002342	DNA binding groove [nucleotide binding]
862967002343	phosphate binding site [ion binding]; other site
862967002344	domain II; other site
862967002345	domain III; other site
862967002346	nucleotide binding site [chemical binding]; other site
862967002347	catalytic site [active]
862967002348	domain IV; other site
862967002349	Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396
862967002350	Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396
862967002351	tRNA (uracil-5-)-methyltransferase Gid; Reviewed; Region: PRK05335
862967002352	Glucose inhibited division protein A; Region: GIDA; pfam01134
862967002353	Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819
862967002354	Putative esterase; Region: Esterase; pfam00756
862967002355	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4947
862967002356	ATP-grasp domain; Region: ATP-grasp_4; pfam13535
862967002357	site-specific tyrosine recombinase XerS; Reviewed; Region: xerS; PRK05084
862967002358	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
862967002359	active site
862967002360	DNA binding site [nucleotide binding]
862967002361	Int/Topo IB signature motif; other site
862967002362	signal recognition particle protein; Provisional; Region: PRK10867
862967002363	SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963
862967002364	The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115
862967002365	P loop; other site
862967002366	GTP binding site [chemical binding]; other site
862967002367	Signal peptide binding domain; Region: SRP_SPB; pfam02978
862967002368	putative DNA-binding protein; Validated; Region: PRK00118
862967002369	Putative helix-turn-helix protein, YlxM / p13 like; Region: UPF0122; pfam04297
862967002370	Transcriptional regulators [Transcription]; Region: PhnF; COG2188
862967002371	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
862967002372	DNA-binding site [nucleotide binding]; DNA binding site
862967002373	UTRA domain; Region: UTRA; pfam07702
862967002374	GMP synthase; Reviewed; Region: guaA; PRK00074
862967002375	Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742
862967002376	AMP/PPi binding site [chemical binding]; other site
862967002377	candidate oxyanion hole; other site
862967002378	catalytic triad [active]
862967002379	potential glutamine specificity residues [chemical binding]; other site
862967002380	The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997
862967002381	ATP Binding subdomain [chemical binding]; other site
862967002382	Dimerization subdomain; other site
862967002383	Alpha/beta hydrolase of unknown function (DUF915); Region: DUF915; pfam06028
862967002384	Lysozyme-like; Region: Lysozyme_like; pfam13702
862967002385	37-kD nucleoid-associated bacterial protein; Region: NA37; cl15473
862967002386	serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011
862967002387	Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378
862967002388	dimer interface [polypeptide binding]; other site
862967002389	active site
862967002390	glycine-pyridoxal phosphate binding site [chemical binding]; other site
862967002391	folate binding site [chemical binding]; other site
862967002392	Putative translation factor (SUA5) [Translation, ribosomal structure and biogenesis]; Region: SUA5; COG0009
862967002393	protein-(glutamine-N5) methyltransferase, release factor-specific; Region: RF_mod_PrmC; TIGR03534
862967002394	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
862967002395	S-adenosylmethionine binding site [chemical binding]; other site
862967002396	peptide chain release factor 1; Validated; Region: prfA; PRK00591
862967002397	This domain is found in peptide chain release factors; Region: PCRF; smart00937
862967002398	RF-1 domain; Region: RF-1; pfam00472
862967002399	thymidine kinase; Provisional; Region: PRK04296
862967002400	4-Oxalocrotonate Tautomerase:  Catalyzes the isomerization of unsaturated ketones. The structure is a homohexamer that is arranged as a trimer of dimers. The hexamer contains six active sites, each formed by residues from three monomers, two from one...; Region: 4Oxalocrotonate_Tautomerase; cl00235
862967002401	active site 1 [active]
862967002402	dimer interface [polypeptide binding]; other site
862967002403	hexamer interface [polypeptide binding]; other site
862967002404	active site 2 [active]
862967002405	multidrug efflux protein; Reviewed; Region: PRK01766
862967002406	Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Vibrio cholerae NorM; Region: MATE_NorM_like; cd13131
862967002407	cation binding site [ion binding]; other site
862967002408	xanthine permease; Region: pbuX; TIGR03173
862967002409	Sulfate transporter family; Region: Sulfate_transp; pfam00916
862967002410	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
862967002411	active site
862967002412	guanosine 5'-monophosphate oxidoreductase; Provisional; Region: PRK05458
862967002413	IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381
862967002414	active site
862967002415	Protein of unknown function (DUF1266); Region: DUF1266; pfam06889
862967002416	Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038
862967002417	ClC chloride channel EriC.  This domain is found in the EriC chloride transporters that mediate the extreme acid resistance response in eubacteria and archaea. This response allows bacteria to survive in the acidic environments by decarboxylation-linked...; Region: EriC; cd01031
862967002418	Cl- selectivity filter; other site
862967002419	Cl- binding residues [ion binding]; other site
862967002420	pore gating glutamate residue; other site
862967002421	dimer interface [polypeptide binding]; other site
862967002422	H+/Cl- coupling transport residue; other site
862967002423	TrkA-C domain; Region: TrkA_C; pfam02080
862967002424	coenzyme A disulfide reductase; Reviewed; Region: PRK09564
862967002425	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
862967002426	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
862967002427	Membrane-associated lipoprotein involved in thiamine biosynthesis [Coenzyme metabolism]; Region: ApbE; COG1477
862967002428	ApbE family; Region: ApbE; pfam02424
862967002429	Predicted flavoprotein [General function prediction only]; Region: COG0431
862967002430	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
862967002431	Predicted flavoprotein [General function prediction only]; Region: COG0431
862967002432	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
862967002433	PAS domain; Region: PAS_10; pfam13596
862967002434	ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: COG4586
862967002435	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
862967002436	Walker A/P-loop; other site
862967002437	ATP binding site [chemical binding]; other site
862967002438	Q-loop/lid; other site
862967002439	ABC transporter signature motif; other site
862967002440	Walker B; other site
862967002441	D-loop; other site
862967002442	H-loop/switch region; other site
862967002443	ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4587
862967002444	ABC-2 family transporter protein; Region: ABC2_membrane_6; cl01496
862967002445	ABC-2 family transporter protein; Region: ABC2_membrane_6; cl01496
862967002446	Predicted signal transduction protein with a C-terminal ATPase domain [Signal transduction mechanisms]; Region: COG2972
862967002447	Cache domain; Region: Cache_1; pfam02743
862967002448	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
862967002449	dimerization interface [polypeptide binding]; other site
862967002450	Histidine kinase; Region: His_kinase; pfam06580
862967002451	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
862967002452	ATP binding site [chemical binding]; other site
862967002453	Mg2+ binding site [ion binding]; other site
862967002454	G-X-G motif; other site
862967002455	Response regulator receiver domain; Region: Response_reg; pfam00072
862967002456	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
862967002457	active site
862967002458	phosphorylation site [posttranslational modification]
862967002459	intermolecular recognition site; other site
862967002460	dimerization interface [polypeptide binding]; other site
862967002461	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
862967002462	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
862967002463	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
862967002464	Peptide methionine sulfoxide reductase [Posttranslational modification, protein turnover, chaperones]; Region: MsrA; COG0225
862967002465	Conserved domain frequently associated with peptide methionine sulfoxide reductase [Posttranslational modification, protein turnover, chaperones]; Region: COG0229
862967002466	SelR domain; Region: SelR; pfam01641
862967002467	TlpA-like family; composed of  TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966
862967002468	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
862967002469	catalytic residues [active]
862967002470	Cytochrome c biogenesis protein [Posttranslational modification, protein turnover, chaperones]; Region: CcdA; COG0785
862967002471	Cytochrome C biogenesis protein transmembrane region; Region: DsbD; pfam02683
862967002472	Branched-chain amino acid transport protein; Region: Branch_AA_trans; pfam05525
862967002473	Predicted metal-sulfur cluster biosynthetic enzyme [General function prediction only]; Region: PaaD; COG2151
862967002474	RNA polymerase sigma factor RpoD; Validated; Region: PRK09210
862967002475	Sigma-70 factor, region 1.1; Region: Sigma70_r1_1; pfam03979
862967002476	Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140
862967002477	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
862967002478	Sigma-70 region 3; Region: Sigma70_r3; pfam04539
862967002479	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
862967002480	DNA binding residues [nucleotide binding]
862967002481	DNA primase; Validated; Region: dnaG; PRK05667
862967002482	CHC2 zinc finger; Region: zf-CHC2; pfam01807
862967002483	DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275
862967002484	TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364
862967002485	active site
862967002486	metal binding site [ion binding]; metal-binding site
862967002487	interdomain interaction site; other site
862967002488	DnaB-helicase binding domain of primase; Region: DnaB_bind; pfam10410
862967002489	Large-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscL; COG1970
862967002490	large-conductance mechanosensitive channel; Reviewed; Region: mscL; PRK00567
862967002491	pyridine nucleotide-disulfide oxidoreductase; Provisional; Region: PRK07251
862967002492	ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314
862967002493	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
862967002494	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
862967002495	Sortase A (SrtA) or subfamily-1 sortases are cysteine transpeptidases found in gram-positive bacteria that anchor surface proteins to peptidoglycans of the bacterial cell wall envelope. They do so by catalyzing a transpeptidation reaction in which the...; Region: Sortase_A_1; cd06165
862967002496	active site
862967002497	catalytic site [active]
862967002498	DNA gyrase subunit A; Validated; Region: PRK05560
862967002499	DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187
862967002500	CAP-like domain; other site
862967002501	active site
862967002502	primary dimer interface [polypeptide binding]; other site
862967002503	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
862967002504	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
862967002505	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
862967002506	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
862967002507	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
862967002508	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
862967002509	L-lactate dehydrogenase; Reviewed; Region: ldh; PRK00066
862967002510	L-2-hydroxyisocapronate dehydrogenases and some bacterial L-lactate dehydrogenases; Region: HicDH_like; cd05291
862967002511	tetramer (dimer of dimers) interface [polypeptide binding]; other site
862967002512	NAD binding site [chemical binding]; other site
862967002513	dimer interface [polypeptide binding]; other site
862967002514	substrate binding site [chemical binding]; other site
862967002515	Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cd02883
862967002516	nudix motif; other site
862967002517	30S ribosomal protein S1; Reviewed; Region: rpsA; PRK06676
862967002518	S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687
862967002519	RNA binding site [nucleotide binding]; other site
862967002520	S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465
862967002521	RNA binding site [nucleotide binding]; other site
862967002522	S1_RPS1_repeat_ec3: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec3; cd05688
862967002523	RNA binding site [nucleotide binding]; other site
862967002524	S1_RPS1_repeat_hs4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_hs4; cd05692
862967002525	RNA binding site [nucleotide binding]; other site
862967002526	Protein of unknown function (DUF2969); Region: DUF2969; pfam11184
862967002527	branched-chain amino acid aminotransferase; Provisional; Region: PRK13357
862967002528	BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids  leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557
862967002529	homodimer interface [polypeptide binding]; other site
862967002530	substrate-cofactor binding pocket; other site
862967002531	catalytic residue [active]
862967002532	DNA topoisomerase IV, A subunit, Gram-positive; Region: parC_Gpos; TIGR01061
862967002533	DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187
862967002534	CAP-like domain; other site
862967002535	active site
862967002536	primary dimer interface [polypeptide binding]; other site
862967002537	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
862967002538	Streptomycin adenylyltransferase; Region: Adenyl_transf; pfam04439
862967002539	DNA topoisomerase IV, B subunit, Gram-positive; Region: parE_Gpos; TIGR01058
862967002540	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
862967002541	Mg2+ binding site [ion binding]; other site
862967002542	G-X-G motif; other site
862967002543	TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822
862967002544	anchoring element; other site
862967002545	dimer interface [polypeptide binding]; other site
862967002546	ATP binding site [chemical binding]; other site
862967002547	TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366
862967002548	active site
862967002549	putative metal-binding site [ion binding]; other site
862967002550	DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986
862967002551	putative glycerol-3-phosphate acyltransferase PlsY; Provisional; Region: PRK00220
862967002552	Deoxycytidylate deaminase domain. Deoxycytidylate deaminase catalyzes the deamination of dCMP to dUMP, providing the nucleotide substrate for thymidylate synthase. The enzyme binds Zn++, which is required for catalytic activity. The activity of the...; Region: deoxycytidylate_deaminase; cd01286
862967002553	catalytic motif [active]
862967002554	Zn binding site [ion binding]; other site
862967002555	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
862967002556	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
862967002557	Uncharacterized protein conserved in bacteria [Function unknown]; Region: DegV; COG1307
862967002558	Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645
862967002559	Protein of unknown function (DUF3307); Region: DUF3307; pfam11750
862967002560	NAD-dependent deacetylase; Provisional; Region: PRK00481
862967002561	SIR2 superfamily of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+; Region: SIR2; cl00195
862967002562	enolase; Provisional; Region: eno; PRK00077
862967002563	Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313
862967002564	dimer interface [polypeptide binding]; other site
862967002565	metal binding site [ion binding]; metal-binding site
862967002566	substrate binding pocket [chemical binding]; other site
862967002567	Protein of unknown function (DUF1694); Region: DUF1694; pfam07997
862967002568	SnoaL-like domain; Region: SnoaL_2; pfam12680
862967002569	Major Facilitator Superfamily; Region: MFS_1; pfam07690
862967002570	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
862967002571	asparaginyl-tRNA synthetase; Validated; Region: asnC; PRK03932
862967002572	AsnRS_cyto_like_N: N-terminal, anticodon recognition domain of the type found in human and Saccharomyces cerevisiae cytoplasmic asparaginyl-tRNA synthetase (AsnRS), in Brugia malayai AsnRs and, in various putative bacterial AsnRSs.  This domain is a...; Region: AsnRS_cyto_like_N; cd04323
862967002573	putative dimer interface [polypeptide binding]; other site
862967002574	putative anticodon binding site; other site
862967002575	Asx tRNA synthetase (AspRS/AsnRS) class II core domain.  Assignment to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs in the core domain. This family includes AsnRS as well as...; Region: AsxRS_core; cd00776
862967002576	homodimer interface [polypeptide binding]; other site
862967002577	motif 1; other site
862967002578	motif 2; other site
862967002579	active site
862967002580	motif 3; other site
862967002581	This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_19; cd07262
862967002582	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
862967002583	aspartate aminotransferase; Provisional; Region: PRK05764
862967002584	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
862967002585	pyridoxal 5'-phosphate binding site [chemical binding]; other site
862967002586	homodimer interface [polypeptide binding]; other site
862967002587	catalytic residue [active]
862967002588	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5353
862967002589	Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413
862967002590	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
862967002591	MarR family; Region: MarR; pfam01047
862967002592	Predicted flavoprotein [General function prediction only]; Region: COG0431
862967002593	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
862967002594	hypothetical protein; Validated; Region: PRK02101
862967002595	Domain of unknown function (DUF1836); Region: DUF1836; pfam08876
862967002596	Predicted membrane protein, hemolysin III homolog [General function prediction only]; Region: COG1272
862967002597	channel protein, hemolysin III family; Region: hlyIII; TIGR01065
862967002598	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
862967002599	Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580
862967002600	TM-ABC transporter signature motif; other site
862967002601	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
862967002602	Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580
862967002603	TM-ABC transporter signature motif; other site
862967002604	ABC-type uncharacterized transport systems, ATPase components [General function prediction only]; Region: COG3845
862967002605	First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216
862967002606	Walker A/P-loop; other site
862967002607	ATP binding site [chemical binding]; other site
862967002608	Q-loop/lid; other site
862967002609	ABC transporter signature motif; other site
862967002610	Walker B; other site
862967002611	D-loop; other site
862967002612	H-loop/switch region; other site
862967002613	Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215
862967002614	Uncharacterized ABC-type transport system, periplasmic component/surface lipoprotein [General function prediction only]; Region: Med; COG1744
862967002615	Periplasmic binding domain of basic membrane lipoprotein, PnrA, in Treponema pallidum and its homologs from other bacteria and Archaea; Region: PBP1_BmpA_PnrA_like; cd06354
862967002616	ligand binding site [chemical binding]; other site
862967002617	2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family; Region: DeoC; cd00959
862967002618	intersubunit interface [polypeptide binding]; other site
862967002619	active site
862967002620	catalytic residue [active]
862967002621	pyrimidine-nucleoside phosphorylase; Reviewed; Region: PRK06078
862967002622	Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885
862967002623	Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591
862967002624	Pyrimidine nucleoside phosphorylase C-terminal domain; Region: PYNP_C; pfam07831
862967002625	16S RNA G1207 methylase RsmC [Translation, ribosomal structure and biogenesis]; Region: RsmC; COG2813
862967002626	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
862967002627	S-adenosylmethionine binding site [chemical binding]; other site
862967002628	pantothenate kinase; Provisional; Region: PRK05439
862967002629	Pantothenate kinase (PanK) catalyzes the phosphorylation of pantothenic acid to form 4'-phosphopantothenic, which is the first of five steps in coenzyme A (CoA) biosynthetic pathway. The reaction carried out by this enzyme is a key regulatory point...; Region: PanK; cd02025
862967002630	ATP-binding site [chemical binding]; other site
862967002631	CoA-binding site [chemical binding]; other site
862967002632	Mg2+-binding site [ion binding]; other site
862967002633	30S ribosomal protein S20; Reviewed; Region: rpsT; PRK00239
862967002634	topology modulation protein; Provisional; Region: PRK07261
862967002635	AAA domain; Region: AAA_17; pfam13207
862967002636	cytoplasmic alpha-amylase; Reviewed; Region: PRK09441
862967002637	Alpha amylase catalytic domain found in bacterial and fungal Alpha amylases (also called 1,4-alpha-D-glucan-4-glucanohydrolase); Region: AmyAc_bac_fung_AmyA; cd11318
862967002638	active site
862967002639	Na/Ca binding site [ion binding]; other site
862967002640	catalytic site [active]
862967002641	Domain of unknown function (DUF1939); Region: DUF1939; pfam09154
862967002642	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
862967002643	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
862967002644	dimer interface [polypeptide binding]; other site
862967002645	phosphorylation site [posttranslational modification]
862967002646	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
862967002647	ATP binding site [chemical binding]; other site
862967002648	Mg2+ binding site [ion binding]; other site
862967002649	G-X-G motif; other site
862967002650	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
862967002651	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
862967002652	active site
862967002653	phosphorylation site [posttranslational modification]
862967002654	intermolecular recognition site; other site
862967002655	dimerization interface [polypeptide binding]; other site
862967002656	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
862967002657	DNA binding site [nucleotide binding]
862967002658	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
862967002659	50S ribosomal protein L19; Provisional; Region: rplS; PRK05338
862967002660	ROK family protein (putative glucokinase); Region: ROK_glcA_fam; TIGR00744
862967002661	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012
862967002662	nucleotide binding site [chemical binding]; other site
862967002663	carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294
862967002664	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
862967002665	Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786
862967002666	Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787
862967002667	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
862967002668	ATP-grasp domain; Region: ATP-grasp_4; cl17255
862967002669	Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424
862967002670	IMP binding site; other site
862967002671	dimer interface [polypeptide binding]; other site
862967002672	interdomain contacts; other site
862967002673	partial ornithine binding site; other site
862967002674	carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564
862967002675	Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; smart01097
862967002676	Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744
862967002677	catalytic site [active]
862967002678	subunit interface [polypeptide binding]; other site
862967002679	aspartate carbamoyltransferase catalytic subunit; Provisional; Region: pyrB; PRK00856
862967002680	Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729
862967002681	Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185
862967002682	uracil transporter; Provisional; Region: PRK10720
862967002683	Pyrimidine operon attenuation protein/uracil phosphoribosyltransferase [Nucleotide transport and metabolism]; Region: PyrR; COG2065
862967002684	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
862967002685	active site
862967002686	Streptococcal histidine triad protein; Region: Strep_his_triad; pfam04270
862967002687	Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799
862967002688	Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond...; Region: LRR_RI; cl15309
862967002689	Leucine-rich repeats; other site
862967002690	Substrate binding site [chemical binding]; other site
862967002691	Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799
862967002692	Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799
862967002693	Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799
862967002694	Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799
862967002695	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1481
862967002696	Sporulation Regulator WhiA N terminal; Region: WhiA_N; pfam10298
862967002697	conserved hypothetical protein, cofD-related; Region: CofD_related; TIGR01826
862967002698	Family of CofD-like proteins and proteins related to YvcK; Region: CofD_YvcK; cd07044
862967002699	dimer interface [polypeptide binding]; other site
862967002700	phosphate binding site [ion binding]; other site
862967002701	glmZ(sRNA)-inactivating NTPase; Provisional; Region: PRK05416
862967002702	Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413
862967002703	active site
862967002704	multimer interface [polypeptide binding]; other site
862967002705	CAAX protease self-immunity; Region: Abi; pfam02517
862967002706	Predicted membrane protein [Function unknown]; Region: COG4478
862967002707	HAD-superfamily subfamily IIA hydrolase, TIGR01457; Region: HAD-SF-IIA-hyp2
862967002708	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
862967002709	active site
862967002710	motif I; other site
862967002711	motif II; other site
862967002712	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
862967002713	Hydrolase of X-linked nucleoside diphosphate N terminal; Region: Nudix_N; pfam12535
862967002714	Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_14; cd04672
862967002715	nudix motif; other site
862967002716	Acyl-ACP thioesterase [Lipid metabolism]; Region: FatA; COG3884
862967002717	4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586
862967002718	active site
862967002719	4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586
862967002720	coproporphyrinogen III oxidase; Provisional; Region: PRK08599
862967002721	HemN C-terminal domain; Region: HemN_C; pfam06969
862967002722	Protein of unknown function (DUF1697); Region: DUF1697; pfam08002
862967002723	Acetyltransferases [General function prediction only]; Region: RimI; COG0456
862967002724	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
862967002725	Coenzyme A binding pocket [chemical binding]; other site
862967002726	excinuclease ABC subunit B; Provisional; Region: PRK05298
862967002727	Myosin and Kinesin motor domain. These ATPases belong to the P-loop NTPase family and provide the driving force in myosin and kinesin mediated processes; Region: Motor_domain; cl00286
862967002728	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
862967002729	ATP-binding site [chemical binding]; other site
862967002730	ATP binding site [chemical binding]; other site
862967002731	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
862967002732	nucleotide binding region [chemical binding]; other site
862967002733	ATP-binding site [chemical binding]; other site
862967002734	Ultra-violet resistance protein B; Region: UvrB; pfam12344
862967002735	UvrB/uvrC motif; Region: UVR; pfam02151
862967002736	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
862967002737	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
862967002738	substrate binding pocket [chemical binding]; other site
862967002739	membrane-bound complex binding site; other site
862967002740	hinge residues; other site
862967002741	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
862967002742	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
862967002743	substrate binding pocket [chemical binding]; other site
862967002744	membrane-bound complex binding site; other site
862967002745	hinge residues; other site
862967002746	ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215
862967002747	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
862967002748	dimer interface [polypeptide binding]; other site
862967002749	conserved gate region; other site
862967002750	putative PBP binding loops; other site
862967002751	ABC-ATPase subunit interface; other site
862967002752	ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126
862967002753	ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262
862967002754	Walker A/P-loop; other site
862967002755	ATP binding site [chemical binding]; other site
862967002756	Q-loop/lid; other site
862967002757	ABC transporter signature motif; other site
862967002758	Walker B; other site
862967002759	D-loop; other site
862967002760	H-loop/switch region; other site
862967002761	ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488
862967002762	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
862967002763	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
862967002764	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
862967002765	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
862967002766	ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254
862967002767	Walker A/P-loop; other site
862967002768	ATP binding site [chemical binding]; other site
862967002769	Q-loop/lid; other site
862967002770	ABC transporter signature motif; other site
862967002771	Walker B; other site
862967002772	D-loop; other site
862967002773	H-loop/switch region; other site
862967002774	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
862967002775	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
862967002776	ATP-binding cassette domain of multidrug resistance protein-like transporters; Region: ABCC_MRP_Like; cd03228
862967002777	Walker A/P-loop; other site
862967002778	ATP binding site [chemical binding]; other site
862967002779	Q-loop/lid; other site
862967002780	ABC transporter signature motif; other site
862967002781	Walker B; other site
862967002782	D-loop; other site
862967002783	H-loop/switch region; other site
862967002784	Formate/nitrite family of transporters [Inorganic ion transport and metabolism]; Region: FocA; COG2116
862967002785	Muramidase (flagellum-specific) [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FlgJ; COG1705
862967002786	YihA (EngB) GTPase family; Region: YihA_EngB; cd01876
862967002787	G1 box; other site
862967002788	GTP/Mg2+ binding site [chemical binding]; other site
862967002789	Switch I region; other site
862967002790	G2 box; other site
862967002791	G3 box; other site
862967002792	Switch II region; other site
862967002793	G4 box; other site
862967002794	G5 box; other site
862967002795	ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342
862967002796	ClpX C4-type zinc finger; Region: zf-C4_ClpX; pfam06689
862967002797	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
862967002798	Walker A motif; other site
862967002799	ATP binding site [chemical binding]; other site
862967002800	Walker B motif; other site
862967002801	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086
862967002802	Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262
862967002803	Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cd00209
862967002804	folate binding site [chemical binding]; other site
862967002805	NADP+ binding site [chemical binding]; other site
862967002806	thymidylate synthase; Reviewed; Region: thyA; PRK01827
862967002807	Thymidylate synthase and pyrimidine hydroxymethylase: Thymidylate synthase (TS) and deoxycytidylate hydroxymethylase (dCMP-HMase) are homologs that catalyze analogous alkylation of C5 of pyrimidine nucleotides. Both enzymes are involved in the...; Region: TS_Pyrimidine_HMase; cd00351
862967002808	dimerization interface [polypeptide binding]; other site
862967002809	active site
862967002810	Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038
862967002811	ClC sycA-like chloride channel proteins. This ClC family presents in bacteria, where it facilitates acid resistance in acidic soil. Mutation of this gene (sycA) in Rhizobium tropici CIAT899 causes serious deficiencies in nodule development, nodulation...; Region: ClC_sycA_like; cd03682
862967002812	putative Cl- selectivity filter; other site
862967002813	putative pore gating glutamate residue; other site
862967002814	hypothetical protein; Provisional; Region: PRK07248
862967002815	Uncharacterized Zn-ribbon-containing protein involved in phosphonate metabolism [Inorganic ion transport and metabolism]; Region: PhnA; COG2824
862967002816	PhnA Zinc-Ribbon; Region: PhnA_Zn_Ribbon; pfam08274
862967002817	PhnA protein; Region: PhnA; pfam03831
862967002818	Phosphotransferase enzyme family; Region: APH; pfam01636
862967002819	Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270
862967002820	Amino Acid Kinases (AAK) superfamily, catalytic domain; present in such enzymes like N-acetylglutamate kinase (NAGK), carbamate kinase (CK), aspartokinase (AK), glutamate-5-kinase (G5K) and UMP kinase (UMPK). The AAK superfamily includes kinases that...; Region: AAK; cl00452
862967002821	nucleotide binding site [chemical binding]; other site
862967002822	Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564
862967002823	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
862967002824	RNA binding surface [nucleotide binding]; other site
862967002825	Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869
862967002826	active site
862967002827	lipoprotein signal peptidase; Provisional; Region: PRK14797
862967002828	Transcriptional regulator [Transcription]; Region: LysR; COG0583
862967002829	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
862967002830	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
862967002831	dimerization interface [polypeptide binding]; other site
862967002832	Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673
862967002833	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
862967002834	Coenzyme A binding pocket [chemical binding]; other site
862967002835	Acetyltransferases [General function prediction only]; Region: RimI; COG0456
862967002836	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
862967002837	Coenzyme A binding pocket [chemical binding]; other site
862967002838	This CD includes bacterial (Agrobacterium tumefaciens and Caulobacter crescentus ProX, and Clostridium sticklandii PrdX) and eukaryotic (Plasmodium falciparum N-terminal ProRS editing domain) sequences. The C. sticklandii PrdX protein, a homolog of the...; Region: PrdX_deacylase; cd04335
862967002839	putative deacylase active site [active]
862967002840	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158
862967002841	active site residue [active]
862967002842	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
862967002843	CoA-disulfide reductase; Region: CoA_CoA_reduc; TIGR03385
862967002844	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
862967002845	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
862967002846	Member of the Rhodanese Homology Domain superfamily. Included in this CD are the Lactococcus lactis NADH oxidase, Bacillus cereus NADH dehydrogenase, and Bacteroides thetaiotaomicron pyridine nucleotide-disulphide oxidoreductase, and similar...; Region: RHOD_Pyr_redox; cd01524
862967002847	active site residue [active]
862967002848	50S ribosomal protein L27; Validated; Region: rpmA; PRK05435
862967002849	Predicted ribosomal protein [Translation, ribosomal structure and biogenesis]; Region: COG2868
862967002850	50S ribosomal protein L21; Validated; Region: rplU; PRK05573
862967002851	Phospholipid methyltransferase; Region: PEMT; pfam04191
862967002852	thiamine biosynthesis protein ThiI; Provisional; Region: PRK01565
862967002853	THUMP domain of thiamine biosynthesis protein ThiI; Region: THUMP_ThiI; cd11716
862967002854	ThiI is required for thiazole synthesis in the thiamine biosynthesis pathway. It belongs to the Adenosine Nucleotide Hydrolysis suoerfamily and predicted to bind to Adenosine nucleotide; Region: ThiI; cd01712
862967002855	Ligand Binding Site [chemical binding]; other site
862967002856	Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104
862967002857	cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402
862967002858	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
862967002859	catalytic residue [active]
862967002860	Firmicute fructose-1,6-bisphosphatase; Region: FBPase_2; pfam06874
862967002861	metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995
862967002862	PEP synthetase regulatory protein; Provisional; Region: PRK05339
862967002863	HTH domain; Region: HTH_11; pfam08279
862967002864	FOG: CBS domain [General function prediction only]; Region: COG0517
862967002865	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354
862967002866	pyruvate phosphate dikinase; Provisional; Region: PRK09279
862967002867	Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326
862967002868	PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391
862967002869	PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896
862967002870	signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416
862967002871	The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115
862967002872	P loop; other site
862967002873	GTP binding site [chemical binding]; other site
862967002874	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
862967002875	haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282
862967002876	active site
862967002877	motif I; other site
862967002878	motif II; other site
862967002879	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cl17915
862967002880	Predicted hydrolases of the HAD superfamily [General function prediction only]; Region: Cof; COG0561
862967002881	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
862967002882	active site
862967002883	motif I; other site
862967002884	motif II; other site
862967002885	haloacid dehalogenase-like hydrolase; Region: HAD; cl17202
862967002886	chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168
862967002887	ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278
862967002888	Walker A/P-loop; other site
862967002889	ATP binding site [chemical binding]; other site
862967002890	Q-loop/lid; other site
862967002891	SMC proteins Flexible Hinge Domain; Region: SMC_hinge; smart00968
862967002892	ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278
862967002893	ABC transporter signature motif; other site
862967002894	Walker B; other site
862967002895	D-loop; other site
862967002896	H-loop/switch region; other site
862967002897	ribonuclease III; Reviewed; Region: rnc; PRK00102
862967002898	RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593
862967002899	dimerization interface [polypeptide binding]; other site
862967002900	active site
862967002901	metal binding site [ion binding]; metal-binding site
862967002902	Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048
862967002903	dsRNA binding site [nucleotide binding]; other site
862967002904	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2832
862967002905	Metal-dependent hydrolases of the beta-lactamase superfamily I [General function prediction only]; Region: PhnP; COG1235
862967002906	Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220
862967002907	phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966
862967002908	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
862967002909	putative active site [active]
862967002910	heme pocket [chemical binding]; other site
862967002911	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
862967002912	dimer interface [polypeptide binding]; other site
862967002913	phosphorylation site [posttranslational modification]
862967002914	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
862967002915	ATP binding site [chemical binding]; other site
862967002916	Mg2+ binding site [ion binding]; other site
862967002917	G-X-G motif; other site
862967002918	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
862967002919	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
862967002920	active site
862967002921	phosphorylation site [posttranslational modification]
862967002922	intermolecular recognition site; other site
862967002923	dimerization interface [polypeptide binding]; other site
862967002924	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
862967002925	DNA binding site [nucleotide binding]
862967002926	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
862967002927	This family is most closely related to the GT1 family of glycosyltransferases. UDP-glucose-diacylglycerol glucosyltransferase (UGDG; also known as 1,2-diacylglycerol 3-glucosyltransferase) catalyzes the transfer of glucose from UDP-glucose to 1; Region: GT1_UGDG_like; cd03817
862967002928	putative ADP-binding pocket [chemical binding]; other site
862967002929	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
862967002930	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
862967002931	catabolite control protein A; Region: ccpA; TIGR01481
862967002932	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
862967002933	DNA binding site [nucleotide binding]
862967002934	domain linker motif; other site
862967002935	Ligand-binding domain of the catabolite control protein A (CcpA), which functions as the major transcriptional regulator of carbon catabolite repression/regulation; Region: PBP1_CcpA_like; cd06298
862967002936	dimerization interface [polypeptide binding]; other site
862967002937	effector binding site; other site
862967002938	Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006
862967002939	Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321
862967002940	Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092
862967002941	active site
862967002942	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
862967002943	S-adenosylmethionine binding site [chemical binding]; other site
862967002944	UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247
862967002945	UDP-glucose 4-epimerase; Region: PLN02240
862967002946	NAD binding site [chemical binding]; other site
862967002947	homodimer interface [polypeptide binding]; other site
862967002948	active site
862967002949	substrate binding site [chemical binding]; other site
862967002950	dTDP-D-glucose 4,6-dehydratase [Cell envelope biogenesis, outer membrane]; Region: RfbB; COG1088
862967002951	dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246
862967002952	NAD binding site [chemical binding]; other site
862967002953	substrate binding site [chemical binding]; other site
862967002954	homodimer interface [polypeptide binding]; other site
862967002955	active site
862967002956	dTDP-4-dehydrorhamnose 3,5-epimerase and related enzymes [Cell envelope biogenesis, outer membrane]; Region: RfbC; COG1898
862967002957	G1P_TT_short is the short form of glucose-1-phosphate thymidylyltransferase; Region: G1P_TT_short; cd02538
862967002958	glucose-1-phosphate thymidylyltransferase, short form; Region: rmlA; TIGR01207
862967002959	substrate binding site; other site
862967002960	tetramer interface; other site
862967002961	MutT homolog-1 (MTH1) is a member of the Nudix hydrolase superfamily. MTH1, the mammalian counterpart of MutT, hydrolyzes oxidized purine nucleoside triphosphates, such as 8-oxo-dGTP and 2-hydroxy-ATP, to monophosphates, thereby preventing the...; Region: MTH1; cd03427
862967002962	putative active site [active]
862967002963	nucleotide binding site [chemical binding]; other site
862967002964	nudix motif; other site
862967002965	putative metal binding site [ion binding]; other site
862967002966	Uncharacterized conserved protein [Function unknown]; Region: COG0327
862967002967	NIF3 (NGG1p interacting factor 3); Region: NIF3; pfam01784
862967002968	Predicted SAM-dependent methyltransferase [General function prediction only]; Region: COG2384
862967002969	Family of unknown function (DUF633); Region: DUF633; pfam04816
862967002970	Sulfatase; Region: Sulfatase; pfam00884
862967002971	Rhamnan synthesis protein F; Region: RgpF; pfam05045
862967002972	ABC-type polysaccharide/polyol phosphate transport system, ATPase component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagH; COG1134
862967002973	ATP-binding cassette component of polysaccharide transport system; Region: ABC_KpsT_Wzt; cd03220
862967002974	Walker A/P-loop; other site
862967002975	ATP binding site [chemical binding]; other site
862967002976	Q-loop/lid; other site
862967002977	ABC transporter signature motif; other site
862967002978	Walker B; other site
862967002979	D-loop; other site
862967002980	H-loop/switch region; other site
862967002981	ABC-type polysaccharide/polyol phosphate export systems, permease component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagG; COG1682
862967002982	ABC-2 type transporter; Region: ABC2_membrane; pfam01061
862967002983	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
862967002984	Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_d; cd04196
862967002985	Probable Catalytic site; other site
862967002986	This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_6; cd04955
862967002987	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
862967002988	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
862967002989	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
862967002990	Predicted membrane protein (DUF2142); Region: DUF2142; pfam09913
862967002991	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
862967002992	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761
862967002993	active site
862967002994	Rhamnan synthesis protein F; Region: RgpF; pfam05045
862967002995	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
862967002996	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
862967002997	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761
862967002998	active site
862967002999	dolichyl-phosphate beta-D-mannosyltransferase; Region: PLN02726
862967003000	DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179
862967003001	Ligand binding site; other site
862967003002	Putative Catalytic site; other site
862967003003	DXD motif; other site
862967003004	Lipopolysaccharide biosynthesis proteins, LPS:glycosyltransferases [Cell envelope biogenesis, outer membrane]; Region: RfaJ; COG1442
862967003005	A4GalT_like proteins catalyze the addition of galactose or glucose residues to the lipooligosaccharide (LOS) or lipopolysaccharide (LPS) of the bacterial cell surface; Region: GT8_A4GalT_like; cd04194
862967003006	Ligand binding site; other site
862967003007	metal-binding site
862967003008	Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244
862967003009	dTDP-6-deoxy-L-lyxo-4-hexulose reductase and related proteins, extended (e) SDRs; Region: dTDP_HR_like_SDR_e; cd05254
862967003010	RmlD substrate binding domain; Region: RmlD_sub_bind; pfam04321
862967003011	NADP binding site [chemical binding]; other site
862967003012	active site
862967003013	putative substrate binding site [chemical binding]; other site
862967003014	undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714
862967003015	Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187
862967003016	Ligand binding site; other site
862967003017	Putative Catalytic site; other site
862967003018	DXD motif; other site
862967003019	lantibiotic protection ABC transporter permease subunit, MutG family; Region: lanti_perm_MutG; TIGR03733
862967003020	lantibiotic protection ABC transporter permease subunit, MutE/EpiE family; Region: lanti_perm_MutE; TIGR03732
862967003021	ATP-binding cassette domain of the bacitracin-resistance transporter; Region: ABC_BcrA_bacitracin_resist; cd03268
862967003022	gallidermin-class lantibiotic protection ABC transporter, ATP-binding subunit; Region: galliderm_ABC; TIGR03740
862967003023	Walker A/P-loop; other site
862967003024	ATP binding site [chemical binding]; other site
862967003025	Q-loop/lid; other site
862967003026	ABC transporter signature motif; other site
862967003027	Walker B; other site
862967003028	D-loop; other site
862967003029	H-loop/switch region; other site
862967003030	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
862967003031	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
862967003032	dimer interface [polypeptide binding]; other site
862967003033	phosphorylation site [posttranslational modification]
862967003034	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
862967003035	ATP binding site [chemical binding]; other site
862967003036	Mg2+ binding site [ion binding]; other site
862967003037	G-X-G motif; other site
862967003038	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
862967003039	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
862967003040	active site
862967003041	phosphorylation site [posttranslational modification]
862967003042	intermolecular recognition site; other site
862967003043	dimerization interface [polypeptide binding]; other site
862967003044	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
862967003045	DNA binding site [nucleotide binding]
862967003046	Peptidase S8 family domain in Lantiobiotic (lanthionine-containing antibiotics) specific proteases; Region: Peptidases_S8_Lantibiotic_specific_protease; cd07482
862967003047	active site
862967003048	catalytic triad [active]
862967003049	Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961
862967003050	Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338
862967003051	catalytic residues [active]
862967003052	catalytic nucleophile [active]
862967003053	Recombinase; Region: Recombinase; pfam07508
862967003054	Recombinase zinc beta ribbon domain; Region: Zn_ribbon_recom; pfam13408
862967003055	RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937
862967003056	Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020
862967003057	conserved cys residue [active]
862967003058	Predicted transcriptional regulator [Transcription]; Region: COG2378
862967003059	HTH domain; Region: HTH_11; pfam08279
862967003060	WYL domain; Region: WYL; pfam13280
862967003061	Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243
862967003062	Relaxase/Mobilisation nuclease domain; Region: Relaxase; pfam03432
862967003063	UvrD/REP helicase N-terminal domain; Region: UvrD-helicase; pfam00580
862967003064	Part of AAA domain; Region: AAA_19; pfam13245
862967003065	Family description; Region: UvrD_C_2; pfam13538
862967003066	AAA ATPase domain; Region: AAA_15; pfam13175
862967003067	TOPRIM_OLD: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in bacterial and archaeal nucleases of the OLD (overcome lysogenization defect) family.  The bacteriophage P2 OLD protein, which has DNase as well as...; Region: TOPRIM_OLD; cd01026
862967003068	putative active site [active]
862967003069	putative metal-binding site [ion binding]; other site
862967003070	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
862967003071	non-specific DNA binding site [nucleotide binding]; other site
862967003072	salt bridge; other site
862967003073	sequence-specific DNA binding site [nucleotide binding]; other site
862967003074	Protein of unknown function (DUF2958); Region: DUF2958; pfam11171
862967003075	Type I restriction-modification system methyltransferase subunit [Defense mechanisms]; Region: HsdM; COG0286
862967003076	Methyltransferase domain; Region: Methyltransf_26; pfam13659
862967003077	DNA methylase [Transcription / DNA replication, recombination, and repair]; Region: COG4646
862967003078	DEAD-like helicases superfamily; Region: DEXDc; smart00487
862967003079	DNA methylase [Transcription / DNA replication, recombination, and repair]; Region: COG4646
862967003080	helicase superfamily c-terminal domain; Region: HELICc; smart00490
862967003081	nucleotide binding region [chemical binding]; other site
862967003082	ATP-binding site [chemical binding]; other site
862967003083	Predicted transcriptional regulator containing an HTH domain and an uncharacterized domain shared with the mammalian protein Schlafen [Transcription]; Region: COG2865
862967003084	Divergent AAA domain; Region: AAA_4; pfam04326
862967003085	ATP-dependent DNA helicase recG C-terminal; Region: HATPase_c_4; pfam13749
862967003086	Regulators of stationary/sporulation gene expression [Transcription]; Region: AbrB; COG2002
862967003087	SpoVT / AbrB like domain; Region: SpoVT_AbrB; smart00966
862967003088	Topoisomerase IA [DNA replication, recombination, and repair]; Region: TopA; COG0550
862967003089	TOPRIM_TopoIA_TopoIII: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to topoisomerase III. Type IA DNA topoisomerases remove (relax) negative supercoils in the DNA by: cleaving...; Region: TOPRIM_TopoIA_TopoIII; cd03362
862967003090	active site
862967003091	putative interdomain interaction site [polypeptide binding]; other site
862967003092	putative metal-binding site [ion binding]; other site
862967003093	putative nucleotide binding site [chemical binding]; other site
862967003094	DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186
862967003095	domain I; other site
862967003096	DNA binding groove [nucleotide binding]
862967003097	phosphate binding site [ion binding]; other site
862967003098	domain II; other site
862967003099	domain III; other site
862967003100	nucleotide binding site [chemical binding]; other site
862967003101	catalytic site [active]
862967003102	domain IV; other site
862967003103	Domain of unknown function (DUF4366); Region: DUF4366; pfam14283
862967003104	AAA-like domain; Region: AAA_10; pfam12846
862967003105	Domain of unknown function DUF87; Region: DUF87; pfam01935
862967003106	PrgI family protein; Region: PrgI; pfam12666
862967003107	Maff2 family; Region: Maff2; pfam12750
862967003108	Replication protein A, class 2b aminoacyl-tRNA synthetases, and related proteins with oligonucleotide/oligosaccharide (OB) fold; Region: RPA_2b-aaRSs_OBF_like; cl09930
862967003109	generic binding surface II; other site
862967003110	generic binding surface I; other site
862967003111	EXLDI protein; Region: EXLDI; TIGR04342
862967003112	Type IV secretory system Conjugative DNA transfer; Region: T4SS-DNA_transf; pfam02534
862967003113	TraM recognition site of TraD and TraG; Region: TraG-D_C; pfam12696
862967003114	Protein of unknown function (DUF3801); Region: DUF3801; pfam12687
862967003115	hypothetical protein; Validated; Region: PRK08116
862967003116	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
862967003117	Walker A motif; other site
862967003118	ATP binding site [chemical binding]; other site
862967003119	Walker B motif; other site
862967003120	Replication initiator protein A (RepA) N-terminus; Region: RepA_N; pfam06970
862967003121	SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase [Translation, ribosomal structure and biogenesis]; Region: TrmA; COG2265
862967003122	TRAM domain; Region: TRAM; cl01282
862967003123	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
862967003124	S-adenosylmethionine binding site [chemical binding]; other site
862967003125	Transcriptional regulator [Transcription]; Region: LytR; COG1316
862967003126	prephenate dehydratase; Provisional; Region: PRK11898
862967003127	Prephenate dehydratase; Region: PDT; pfam00800
862967003128	C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905
862967003129	putative L-Phe binding site [chemical binding]; other site
862967003130	shikimate kinase; Reviewed; Region: aroK; PRK00131
862967003131	Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464
862967003132	ADP binding site [chemical binding]; other site
862967003133	magnesium binding site [ion binding]; other site
862967003134	putative shikimate binding site; other site
862967003135	3-phosphoshikimate 1-carboxyvinyltransferase; Provisional; Region: PRK02427
862967003136	EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556
862967003137	hinge; other site
862967003138	active site
862967003139	hypothetical protein; Provisional; Region: PRK13676
862967003140	prephenate dehydrogenase; Validated; Region: PRK06545
862967003141	prephenate dehydrogenase; Validated; Region: PRK08507
862967003142	C-terminal ACT domain of the monofunctional, NAD dependent, prephenate dehydrogenase (PDH); Region: ACT_PDH-BS; cd04909
862967003143	Protein of unknown function (DUF1634); Region: DUF1634; pfam07843
862967003144	Sulfite exporter TauE/SafE; Region: TauE; pfam01925
862967003145	Chorismate synthase [Amino acid transport and metabolism]; Region: AroC; COG0082
862967003146	Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304
862967003147	Tetramer interface [polypeptide binding]; other site
862967003148	active site
862967003149	FMN-binding site [chemical binding]; other site
862967003150	Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195
862967003151	active site
862967003152	dimer interface [polypeptide binding]; other site
862967003153	metal binding site [ion binding]; metal-binding site
862967003154	shikimate 5-dehydrogenase; Reviewed; Region: aroE; PRK00258
862967003155	Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501
862967003156	NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065
862967003157	shikimate binding site; other site
862967003158	NAD(P) binding site [chemical binding]; other site
862967003159	3-dehydroquinate dehydratase [Amino acid transport and metabolism]; Region: AroD; COG0710
862967003160	Type I 3-dehydroquinase, (3-dehydroquinate dehydratase or DHQase); Region: DHQase_I; cd00502
862967003161	active site
862967003162	catalytic residue [active]
862967003163	dimer interface [polypeptide binding]; other site
862967003164	Predicted SAM-dependent methyltransferases [General function prediction only]; Region: COG1092
862967003165	Middle domain of the SAM-dependent methyltransferase RlmI and related proteins; Region: RlmI_M_like; cd11572
862967003166	putative RNA binding site [nucleotide binding]; other site
862967003167	Methyltransferase domain; Region: Methyltransf_26; pfam13659
862967003168	Phosphoglycerol transferase and related proteins, alkaline phosphatase superfamily [Cell envelope biogenesis, outer membrane]; Region: MdoB; COG1368
862967003169	Sulfatase; Region: Sulfatase; pfam00884
862967003170	CRISPR/Cas system-associated protein Csm6; Region: Csm6_III-A; cl09873
862967003171	purine nucleoside phosphorylase; Reviewed; Region: deoD; PRK05819
862967003172	purine nucleoside phosphorylase; Provisional; Region: PRK08202
862967003173	RPI_A: Ribose 5-phosphate isomerase type A (RPI_A) subfamily; RPI catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate, the first step of the non-oxidative branch of the pentose phosphate pathway. This reaction leads to the...; Region: RPI_A; cd01398
862967003174	tetramer (dimer of dimers) interface [polypeptide binding]; other site
862967003175	active site
862967003176	dimer interface [polypeptide binding]; other site
862967003177	tRNA modification GTPase TrmE; Reviewed; Region: trmE; PRK05291
862967003178	GTP-binding protein TrmE N-terminus; Region: TrmE_N; pfam10396
862967003179	trmE is a tRNA modification GTPase; Region: trmE; cd04164
862967003180	G1 box; other site
862967003181	GTP/Mg2+ binding site [chemical binding]; other site
862967003182	Switch I region; other site
862967003183	G2 box; other site
862967003184	Switch II region; other site
862967003185	G3 box; other site
862967003186	G4 box; other site
862967003187	G5 box; other site
862967003188	Catalytic cysteine-containing C-terminus of GTPase, MnmE; Region: GTPase_Cys_C; pfam12631
862967003189	CAAX protease self-immunity; Region: Abi; pfam02517
862967003190	Endo-N-acetylmuramidases (muramidases) are lysozymes (also referred to as peptidoglycan hydrolases) that degrade bacterial cell walls by catalyzing the hydrolysis of 1,4-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues; Region: GH25_muramidase; cl10448
862967003191	Glycosyl hydrolases family 25; Region: Glyco_hydro_25; pfam01183
862967003192	active site
862967003193	GBS Bsp-like repeat; Region: GBS_Bsp-like; pfam08481
862967003194	GBS Bsp-like repeat; Region: GBS_Bsp-like; pfam08481
862967003195	GBS Bsp-like repeat; Region: GBS_Bsp-like; pfam08481
862967003196	GBS Bsp-like repeat; Region: GBS_Bsp-like; pfam08481
862967003197	GBS Bsp-like repeat; Region: GBS_Bsp-like; pfam08481
862967003198	GBS Bsp-like repeat; Region: GBS_Bsp-like; pfam08481
862967003199	GBS Bsp-like repeat; Region: GBS_Bsp-like; pfam08481
862967003200	Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various bacteriocins (mostly non-lantibiotic); Region: Peptidase_C39_like; cl00296
862967003201	putative active site [active]
862967003202	triosephosphate isomerase; Provisional; Region: PRK14567
862967003203	Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311
862967003204	substrate binding site [chemical binding]; other site
862967003205	dimer interface [polypeptide binding]; other site
862967003206	catalytic triad [active]
862967003207	elongation factor Tu; Reviewed; Region: PRK00049
862967003208	Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884
862967003209	G1 box; other site
862967003210	GEF interaction site [polypeptide binding]; other site
862967003211	GTP/Mg2+ binding site [chemical binding]; other site
862967003212	Switch I region; other site
862967003213	G2 box; other site
862967003214	G3 box; other site
862967003215	Switch II region; other site
862967003216	G4 box; other site
862967003217	G5 box; other site
862967003218	EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697
862967003219	Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707
862967003220	Antibiotic Binding Site [chemical binding]; other site
862967003221	Sigma factor regulator C-terminal; Region: Sigma_reg_C; pfam13791
862967003222	RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937
862967003223	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
862967003224	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
862967003225	DNA binding residues [nucleotide binding]
862967003226	phosphoenolpyruvate carboxylase; Reviewed; Region: PRK00009
862967003227	Phosphoenolpyruvate carboxylase [Energy production and conversion]; Region: Ppc; COG2352
862967003228	Bacterial cell division membrane protein [Cell division and chromosome partitioning]; Region: FtsW; COG0772
862967003229	Lyzozyme M1 (1,4-beta-N-acetylmuramidase) [Cell envelope biogenesis, outer membrane]; Region: Acm; COG3757
862967003230	PlyB is a bacteriophage endolysin that displays potent lytic activity toward Bacillus anthracis.  PlyB has an N-terminal glycosyl hydrolase family 25 (GH25) catalytic domain and a C-terminal bacterial SH3-like domain, SH3b.  Both domains are required for...; Region: GH25_PlyB-like; cd06523
862967003231	active site
862967003232	SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379
862967003233	sulfate ABC transporter, ATP-binding protein; Region: 3a0106s01; TIGR00968
862967003234	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
862967003235	Walker A/P-loop; other site
862967003236	ATP binding site [chemical binding]; other site
862967003237	Q-loop/lid; other site
862967003238	ABC transporter signature motif; other site
862967003239	Walker B; other site
862967003240	D-loop; other site
862967003241	H-loop/switch region; other site
862967003242	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
862967003243	dimer interface [polypeptide binding]; other site
862967003244	conserved gate region; other site
862967003245	putative PBP binding loops; other site
862967003246	ABC-ATPase subunit interface; other site
862967003247	Periplasmic glycine betaine/choline-binding (lipo)protein of an ABC-type transport system (osmoprotectant binding protein) [Cell envelope biogenesis, outer membrane]; Region: OpuBC; COG1732
862967003248	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
862967003249	MarR family; Region: MarR_2; pfam12802
862967003250	Uncharacterized subfamily of Uracil-DNA glycosylases; Region: UDG_like_1; cd10033
862967003251	putative uracil binding site [chemical binding]; other site
862967003252	putative active site [active]
862967003253	dipeptidase PepV; Reviewed; Region: PRK07318
862967003254	M20 Peptidase Xaa-His dipeptidase (PepV) degrades hydrophobic dipeptides; Region: M20_PepV; cd03888
862967003255	active site
862967003256	metal binding site [ion binding]; metal-binding site
862967003257	Nitroreductase-like family 1. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_1; cd02137
862967003258	dimer interface [polypeptide binding]; other site
862967003259	FMN binding site [chemical binding]; other site
862967003260	excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558
862967003261	Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434
862967003262	GIY-YIG motif/motif A; other site
862967003263	active site
862967003264	catalytic site [active]
862967003265	putative DNA binding site [nucleotide binding]; other site
862967003266	metal binding site [ion binding]; metal-binding site
862967003267	UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459
862967003268	Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism]; Region: PtsA; COG1080
862967003269	PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524
862967003270	PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391
862967003271	PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896
862967003272	Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367
862967003273	dimerization domain swap beta strand [polypeptide binding]; other site
862967003274	regulatory protein interface [polypeptide binding]; other site
862967003275	active site
862967003276	regulatory phosphorylation site [posttranslational modification]; other site
862967003277	NrdH-redoxin (NrdH) family; NrdH is a small monomeric protein with a conserved redox active CXXC motif within a TRX fold, characterized by a glutaredoxin (GRX)-like sequence and TRX-like activity profile. In vitro, it displays protein disulfide reductase...; Region: NrdH; cd02976
862967003278	catalytic residues [active]
862967003279	ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK07306
862967003280	Ribonucleotide reductase N-terminal; Region: RNR_N; pfam08343
862967003281	Class I ribonucleotide reductase; Region: RNR_I; cd01679
862967003282	active site
862967003283	dimer interface [polypeptide binding]; other site
862967003284	catalytic residues [active]
862967003285	effector binding site; other site
862967003286	Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939
862967003287	Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109
862967003288	ribonucleotide-diphosphate reductase subunit beta; Provisional; Region: nrdF2; PRK13966
862967003289	Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049
862967003290	dimer interface [polypeptide binding]; other site
862967003291	putative radical transfer pathway; other site
862967003292	diiron center [ion binding]; other site
862967003293	tyrosyl radical; other site
862967003294	CAAX protease self-immunity; Region: Abi; pfam02517
862967003295	Peptidase family C69; Region: Peptidase_C69; cl17793
862967003296	Putative intracellular protease/amidase [General function prediction only]; Region: ThiJ; COG0693
862967003297	Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020
862967003298	conserved cys residue [active]
862967003299	1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204
862967003300	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989
862967003301	putative acyl-acceptor binding pocket; other site
862967003302	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474
862967003303	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
862967003304	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
862967003305	motif II; other site
862967003306	Predicted membrane protein [Function unknown]; Region: COG2035
862967003307	This CD includes cysteinyl-tRNA(Pro) deacylases from Haemophilus influenzae and Escherichia coli and other related bacterial proteins. These trans-acting, single-domain proteins are homologs of ProX and also the cis-acting prolyl-tRNA synthetase (ProRS)...; Region: YbaK_deacylase; cd00002
862967003308	putative deacylase active site [active]
862967003309	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
862967003310	catalytic core [active]
862967003311	lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484
862967003312	LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322
862967003313	dimer interface [polypeptide binding]; other site
862967003314	putative anticodon binding site; other site
862967003315	Lys_tRNA synthetase (LysRS) class II core domain. Class II LysRS is a dimer which attaches a lysine to the 3' OH group of ribose of the appropriate tRNA. Its assignment to class II aaRS is based upon its structure and the presence of three...; Region: LysRS_core; cd00775
862967003316	motif 1; other site
862967003317	active site
862967003318	motif 2; other site
862967003319	motif 3; other site
862967003320	TfoX N-terminal domain; Region: TfoX_N; cl17592
862967003321	This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_10; cd07251
862967003322	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
862967003323	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
862967003324	Uncharacterized protein family (UPF0157); Region: UPF0157; pfam04229
862967003325	Response regulator containing CheY-like receiver domain and AraC-type DNA-binding domain [Signal transduction mechanisms]; Region: COG4753
862967003326	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
862967003327	active site
862967003328	phosphorylation site [posttranslational modification]
862967003329	intermolecular recognition site; other site
862967003330	dimerization interface [polypeptide binding]; other site
862967003331	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
862967003332	Predicted signal transduction protein with a C-terminal ATPase domain [Signal transduction mechanisms]; Region: COG2972
862967003333	Histidine kinase; Region: His_kinase; pfam06580
862967003334	Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518
862967003335	ATP binding site [chemical binding]; other site
862967003336	Mg2+ binding site [ion binding]; other site
862967003337	G-X-G motif; other site
862967003338	Protein of unknown function, DUF624; Region: DUF624; cl02369
862967003339	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
862967003340	Domain of unknown function (DUF3502); Region: DUF3502; pfam12010
862967003341	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
862967003342	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
862967003343	dimer interface [polypeptide binding]; other site
862967003344	conserved gate region; other site
862967003345	ABC-ATPase subunit interface; other site
862967003346	ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209
862967003347	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
862967003348	ABC-ATPase subunit interface; other site
862967003349	Glycosyl hydrolase family 20 (GH20) catalytic domain of N-acetyl-beta-D-glucosaminidase (GcnA, also known as BhsA) and related proteins. GcnA  is an exoglucosidase which cleaves N-acetyl-beta-D-galactosamine (NAG) and N-acetyl-beta-D-galactosamine...; Region: GH20_GcnA-like; cd06565
862967003350	Glycosyl hydrolase family 20, catalytic domain; Region: Glyco_hydro_20; pfam00728
862967003351	putative active site [active]
862967003352	Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940
862967003353	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012
862967003354	nucleotide binding site [chemical binding]; other site
862967003355	Alpha-mannosidase [Carbohydrate transport and metabolism]; Region: AMS1; COG0383
862967003356	N-terminal catalytic domain of SPGH38, a putative alpha-mannosidase of Streptococcus pyogenes, and its prokaryotic homologs; glycoside hydrolase family 38 (GH38); Region: GH38N_AMII_SpGH38_like; cd10814
862967003357	active site
862967003358	metal binding site [ion binding]; metal-binding site
862967003359	homodimer interface [polypeptide binding]; other site
862967003360	catalytic site [active]
862967003361	Alpha mannosidase, middle domain; Region: Alpha-mann_mid; smart00872
862967003362	Uncharacterized conserved protein [Function unknown]; Region: COG3538
862967003363	Protein of unknown function (DUF1237); Region: DUF1237; pfam06824
862967003364	Putative alpha-1,2-mannosidase [Carbohydrate transport and metabolism]; Region: COG3537
862967003365	Glycosyl hydrolase family 92; Region: Glyco_hydro_92; pfam07971
862967003366	Endo-beta-N-acetylglucosaminidase D [Carbohydrate transport and metabolism]; Region: COG4724
862967003367	Glycosyl hydrolase family 85; Region: Glyco_hydro_85; pfam03644
862967003368	active site
862967003369	Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes; Region: FA58C; cl12042
862967003370	Glycerol dehydrogenase and related enzymes [Energy production and conversion]; Region: GldA; COG0371
862967003371	Glycerol dehydrogenases (GlyDH) catalyzes oxidation of glycerol to dihydroxyacetone in glycerol dissmilation; Region: GlyDH; cd08170
862967003372	dimer interface [polypeptide binding]; other site
862967003373	active site
862967003374	metal binding site [ion binding]; metal-binding site
862967003375	Transaldolase-like fructose-6-phosphate aldolases (FSA) found in bacteria and archaea; Region: Transaldolase_FSA; cd00956
862967003376	active site
862967003377	intersubunit interactions; other site
862967003378	catalytic residue [active]
862967003379	Pyruvate-formate lyase [Energy production and conversion]; Region: PflD; COG1882
862967003380	Pyruvate formate lyase 2 and related enzymes; Region: PFL2_DhaB_BssA; cd01677
862967003381	dimer interface [polypeptide binding]; other site
862967003382	active site
862967003383	glycine loop; other site
862967003384	Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455
862967003385	cellobiose phosphotransferase system IIC component; Reviewed; Region: celD; PRK09592
862967003386	PTS_IIB_chitobiose_lichenan: subunit IIB of enzyme II (EII) of the N,N-diacetylchitobiose-specific and lichenan-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In these systems, EII is either a lichenan- or an N; Region: PTS_IIB_chitobiose_lichenan; cd05564
862967003387	active site
862967003388	P-loop; other site
862967003389	phosphorylation site [posttranslational modification]
862967003390	PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_lac; cd00215
862967003391	active site
862967003392	methionine cluster; other site
862967003393	phosphorylation site [posttranslational modification]
862967003394	metal binding site [ion binding]; metal-binding site
862967003395	Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription]; Region: DeoR; COG2390
862967003396	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
862967003397	DNA binding residues [nucleotide binding]
862967003398	Putative sugar-binding domain; Region: Sugar-bind; pfam04198
862967003399	Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349
862967003400	DeoR-like helix-turn-helix domain; Region: HTH_DeoR; pfam08220
862967003401	DeoR C terminal sensor domain; Region: DeoRC; pfam00455
862967003402	glycyl-radical enzyme activating protein family; Region: PFLE_PFLC; TIGR02494
862967003403	The nitrogenase enzyme system catalyzes the ATP-dependent reduction of dinitrogen to ammonia.  This group contains both alpha and beta subunits of component 1 of the three known genetically distinct types of nitrogenase systems: a molybdenum-dependent; Region: Oxidoreductase_nitrogenase; cl02775
862967003404	Escherichia coli YfcE and related proteins, metallophosphatase domain; Region: MPP_YfcE; cd00841
862967003405	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
862967003406	active site
862967003407	metal binding site [ion binding]; metal-binding site
862967003408	homotetramer interface [polypeptide binding]; other site
862967003409	FtsX-like permease family; Region: FtsX; pfam02687
862967003410	ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577
862967003411	FtsX-like permease family; Region: FtsX; pfam02687
862967003412	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
862967003413	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
862967003414	Walker A/P-loop; other site
862967003415	ATP binding site [chemical binding]; other site
862967003416	Q-loop/lid; other site
862967003417	ABC transporter signature motif; other site
862967003418	Walker B; other site
862967003419	D-loop; other site
862967003420	H-loop/switch region; other site
862967003421	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
862967003422	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
862967003423	threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK00413
862967003424	TGS _ThrRS_N:  ThrRS (threonyl-tRNA Synthetase)  is a class II tRNA synthetase that couples threonine to its cognate tRNA.  In addition to its catalytic and anticodon-binding domains, ThrRS has an N-terminal TGS domain, named after the ThrRS, GTPase, and...; Region: TGS_ThrRS_N; cd01667
862967003425	Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863
862967003426	Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771
862967003427	active site
862967003428	dimer interface [polypeptide binding]; other site
862967003429	motif 1; other site
862967003430	motif 2; other site
862967003431	motif 3; other site
862967003432	ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860
862967003433	anticodon binding site; other site
862967003434	AAA domain; Region: AAA_17; pfam13207
862967003435	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
862967003436	HAMP domain; Region: HAMP; pfam00672
862967003437	dimerization interface [polypeptide binding]; other site
862967003438	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
862967003439	dimer interface [polypeptide binding]; other site
862967003440	phosphorylation site [posttranslational modification]
862967003441	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
862967003442	ATP binding site [chemical binding]; other site
862967003443	Mg2+ binding site [ion binding]; other site
862967003444	G-X-G motif; other site
862967003445	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
862967003446	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
862967003447	active site
862967003448	phosphorylation site [posttranslational modification]
862967003449	intermolecular recognition site; other site
862967003450	dimerization interface [polypeptide binding]; other site
862967003451	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
862967003452	DNA binding site [nucleotide binding]
862967003453	Lactonase, 7-bladed beta-propeller; Region: Lactonase; pfam10282
862967003454	septation ring formation regulator EzrA; Provisional; Region: PRK04778
862967003455	Protein of unknown function (DUF1664); Region: DUF1664; pfam07889
862967003456	DNA gyrase subunit B; Validated; Region: gyrB; PRK05644
862967003457	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
862967003458	Mg2+ binding site [ion binding]; other site
862967003459	G-X-G motif; other site
862967003460	TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822
862967003461	anchoring element; other site
862967003462	dimer interface [polypeptide binding]; other site
862967003463	ATP binding site [chemical binding]; other site
862967003464	TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366
862967003465	active site
862967003466	putative metal-binding site [ion binding]; other site
862967003467	DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986
862967003468	haloacid dehalogenase superfamily, subfamily IA, variant 1 with third motif having Dx(3-4)D or Dx(3-4)E; Region: HAD-SF-IA-v1; TIGR01549
862967003469	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
862967003470	motif II; other site
862967003471	DJ-1 family protein; Region: not_thiJ; TIGR01383
862967003472	Type 1 glutamine amidotransferase (GATase1)-like domain found in Human DJ-1; Region: GATase1_DJ-1; cd03135
862967003473	conserved cys residue [active]
862967003474	Bacterial cell division membrane protein [Cell division and chromosome partitioning]; Region: FtsW; COG0772
862967003475	Predicted membrane protein [Function unknown]; Region: COG2855
862967003476	bifunctional ATP-dependent DNA helicase/DNA polymerase III subunit epsilon; Validated; Region: PRK07246
862967003477	DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127
862967003478	active site
862967003479	catalytic site [active]
862967003480	substrate binding site [chemical binding]; other site
862967003481	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
862967003482	ATP binding site [chemical binding]; other site
862967003483	Helicase C-terminal domain; Region: Helicase_C_2; pfam13307
862967003484	Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491
862967003485	Cell division protein [Cell division and chromosome partitioning]; Region: FtsX; COG2177
862967003486	FtsX-like permease family; Region: FtsX; pfam02687
862967003487	Predicted ATPase involved in cell division [Cell division and chromosome partitioning]; Region: FtsE; COG2884
862967003488	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
862967003489	Walker A/P-loop; other site
862967003490	ATP binding site [chemical binding]; other site
862967003491	Q-loop/lid; other site
862967003492	ABC transporter signature motif; other site
862967003493	Walker B; other site
862967003494	D-loop; other site
862967003495	H-loop/switch region; other site
862967003496	This domain is found in peptide chain release factors; Region: PCRF; smart00937
862967003497	Protein chain release factor B [Translation, ribosomal structure and biogenesis]; Region: PrfB; COG1186
862967003498	RF-1 domain; Region: RF-1; pfam00472
862967003499	Protein of unknown function (DUF2785); Region: DUF2785; pfam10978
862967003500	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474
862967003501	Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; smart00831
862967003502	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
862967003503	Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246
862967003504	haloacid dehalogenase-like hydrolase; Region: HAD; pfam12710
862967003505	Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689
862967003506	Domain of unknown function (DUF1934); Region: DUF1934; pfam09148
862967003507	HD superfamily phosphohydrolases [General function prediction only]; Region: COG1078
862967003508	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
862967003509	Zn2+ binding site [ion binding]; other site
862967003510	Mg2+ binding site [ion binding]; other site
862967003511	sugar phosphate phosphatase; Provisional; Region: PRK10513
862967003512	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
862967003513	active site
862967003514	motif I; other site
862967003515	motif II; other site
862967003516	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
862967003517	FemAB family; Region: FemAB; pfam02388
862967003518	Acetyltransferase (GNAT) domain; Region: Acetyltransf_6; pfam13480
862967003519	FemAB family; Region: FemAB; pfam02388
862967003520	Acetyltransferase (GNAT) domain; Region: Acetyltransf_6; pfam13480
862967003521	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
862967003522	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
862967003523	ATP-binding cassette domain of multidrug resistance protein-like transporters; Region: ABCC_MRP_Like; cd03228
862967003524	Walker A/P-loop; other site
862967003525	ATP binding site [chemical binding]; other site
862967003526	Q-loop/lid; other site
862967003527	ABC transporter signature motif; other site
862967003528	Walker B; other site
862967003529	D-loop; other site
862967003530	H-loop/switch region; other site
862967003531	alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252
862967003532	Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673
862967003533	motif 1; other site
862967003534	active site
862967003535	motif 2; other site
862967003536	motif 3; other site
862967003537	Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863
862967003538	DHHA1 domain; Region: DHHA1; pfam02272
862967003539	Tubby C 2; Region: Tub_2; cl02043
862967003540	foldase protein PrsA; Reviewed; Region: prsA; PRK01326
862967003541	PPIC-type PPIASE domain; Region: Rotamase_2; cl08278
862967003542	Predicted O-methyltransferase [General function prediction only]; Region: COG4122
862967003543	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
862967003544	S-adenosylmethionine binding site [chemical binding]; other site
862967003545	Oligoendopeptidase F [Amino acid transport and metabolism]; Region: COG1164
862967003546	Peptidase family M3B Oligopeptidase F (PepF); Region: M3B_PepF_3; cd09608
862967003547	active site
862967003548	Zn binding site [ion binding]; other site
862967003549	Competence protein CoiA-like family; Region: CoiA; pfam06054
862967003550	Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455
862967003551	cellobiose phosphotransferase system IIC component; Reviewed; Region: celD; PRK09592
862967003552	PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_lac; cd00215
862967003553	methionine cluster; other site
862967003554	active site
862967003555	phosphorylation site [posttranslational modification]
862967003556	metal binding site [ion binding]; metal-binding site
862967003557	Transcriptional antiterminator [Transcription]; Region: BglG; COG3711
862967003558	HTH domain; Region: HTH_11; pfam08279
862967003559	Mga helix-turn-helix domain; Region: Mga; pfam05043
862967003560	PRD domain; Region: PRD; pfam00874
862967003561	PRD domain; Region: PRD; pfam00874
862967003562	PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568
862967003563	active site
862967003564	P-loop; other site
862967003565	phosphorylation site [posttranslational modification]
862967003566	Phosphoenolpyruvate-dependent sugar phosphotransferase system, EIIA 2; Region: PTS_EIIA_2; pfam00359
862967003567	active site
862967003568	phosphorylation site [posttranslational modification]
862967003569	cellobiose phosphotransferase system IIB component; Reviewed; Region: celB; PRK09590
862967003570	active site
862967003571	P-loop; other site
862967003572	phosphorylation site [posttranslational modification]
862967003573	Uncharacterized conserved protein [Function unknown]; Region: COG4095
862967003574	6-phospho-beta-glucosidase; Reviewed; Region: celA; PRK09589
862967003575	beta-galactosidase; Region: BGL; TIGR03356
862967003576	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
862967003577	Major Facilitator Superfamily; Region: MFS_1; pfam07690
862967003578	putative substrate translocation pore; other site
862967003579	D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768
862967003580	Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872
862967003581	Domain of unknown function (DUF1958); Region: DUF1958; pfam09211
862967003582	6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363
862967003583	GlcN6P_deaminase: Glucosamine-6-phosphate (GlcN6P) deaminase subfamily; GlcN6P deaminase catalyzes the reversible conversion of GlcN6P to D-fructose-6-phosphate (Fru6P) and ammonium. The reaction is an aldo-keto isomerization coupled with an amination or...; Region: GlcN6P_deaminase; cd01399
862967003584	active site
862967003585	trimer interface [polypeptide binding]; other site
862967003586	allosteric site; other site
862967003587	active site lid [active]
862967003588	hexamer (dimer of trimers) interface [polypeptide binding]; other site
862967003589	S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Provisional; Region: queA; PRK00147
862967003590	S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Region: queA; TIGR00113
862967003591	Arginine repressor [Transcription]; Region: ArgR; COG1438
862967003592	Arginine repressor, DNA binding domain; Region: Arg_repressor; pfam01316
862967003593	Arginine repressor, C-terminal domain; Region: Arg_repressor_C; pfam02863
862967003594	hypothetical protein; Provisional; Region: PRK07205
862967003595	M20 Peptidase Xaa-His dipeptidase (PepV) degrades hydrophobic dipeptides; Region: M20_PepV; cd03888
862967003596	active site
862967003597	metal binding site [ion binding]; metal-binding site
862967003598	Predicted membrane protein [Function unknown]; Region: COG1288
862967003599	C4-dicarboxylate anaerobic carrier; Region: DcuC; pfam03606
862967003600	carbamate kinase; Reviewed; Region: PRK12686
862967003601	AAK_CK: Carbamate kinase (CK) catalyzes both the ATP-phosphorylation of carbamate and carbamoyl phosphate (CP) utilization with the production of ATP from ADP and CP. Both CK (this CD) and nonhomologous CP synthetase synthesize carbamoyl phosphate, an...; Region: AAK_CK; cd04235
862967003602	putative substrate binding site [chemical binding]; other site
862967003603	nucleotide binding site [chemical binding]; other site
862967003604	nucleotide binding site [chemical binding]; other site
862967003605	homodimer interface [polypeptide binding]; other site
862967003606	ornithine carbamoyltransferase; Validated; Region: PRK02102
862967003607	Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729
862967003608	Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185
862967003609	arginine deiminase; Provisional; Region: PRK01388
862967003610	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
862967003611	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
862967003612	ligand binding site [chemical binding]; other site
862967003613	Crp-like helix-turn-helix domain; Region: HTH_Crp_2; pfam13545
862967003614	putative switch regulator; other site
862967003615	non-specific DNA interactions [nucleotide binding]; other site
862967003616	DNA binding site [nucleotide binding]
862967003617	sequence specific DNA binding site [nucleotide binding]; other site
862967003618	putative cAMP binding site [chemical binding]; other site
862967003619	Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872
862967003620	TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947
862967003621	catalytic residues [active]
862967003622	Bacteriocin class II with double-glycine leader peptide; Region: Bacteriocin_IIc; pfam10439
862967003623	Enterocin A Immunity; Region: EntA_Immun; pfam08951
862967003624	Bacteriocin class II with double-glycine leader peptide; Region: Bacteriocin_IIc; pfam10439
862967003625	CAAX protease self-immunity; Region: Abi; pfam02517
862967003626	Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279
862967003627	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
862967003628	active site
862967003629	phosphorylation site [posttranslational modification]
862967003630	intermolecular recognition site; other site
862967003631	dimerization interface [polypeptide binding]; other site
862967003632	LytTr DNA-binding domain; Region: LytTR; pfam04397
862967003633	Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518
862967003634	ATP binding site [chemical binding]; other site
862967003635	Mg2+ binding site [ion binding]; other site
862967003636	G-X-G motif; other site
862967003637	COMC family; Region: ComC; pfam03047
862967003638	bacteriocin secretion accessory protein; Region: bacteriocin_acc; TIGR01000
862967003639	HlyD family secretion protein; Region: HlyD_3; pfam13437
862967003640	A sub-family of peptidase family C39. Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various...; Region: Peptidase_C39B; cd02418
862967003641	ABC-type bacteriocin transporter; Region: bacteriocin_ABC; TIGR01193
862967003642	putative active site [active]
862967003643	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
862967003644	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
862967003645	Walker A/P-loop; other site
862967003646	ATP binding site [chemical binding]; other site
862967003647	Q-loop/lid; other site
862967003648	ABC transporter signature motif; other site
862967003649	Walker B; other site
862967003650	D-loop; other site
862967003651	H-loop/switch region; other site
862967003652	Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605
862967003653	Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081
862967003654	Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777
862967003655	DNA polymerase III subunit delta; Reviewed; Region: holA; PRK05574
862967003656	DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144
862967003657	Predicted RNA-bindining protein (contains S1 and HTH domains) [General function prediction only]; Region: COG2996
862967003658	S1 domain; Region: S1_2; pfam13509
862967003659	Ribosomal protein S1-like RNA-binding domain; Region: S1; smart00316
862967003660	ribosome recycling factor; Reviewed; Region: frr; PRK00083
862967003661	Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation.  Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520
862967003662	hinge region; other site
862967003663	UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254
862967003664	putative nucleotide binding site [chemical binding]; other site
862967003665	uridine monophosphate binding site [chemical binding]; other site
862967003666	homohexameric interface [polypeptide binding]; other site
862967003667	Ribosomal protein L1.  The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA.  In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403
862967003668	mRNA/rRNA interface [nucleotide binding]; other site
862967003669	50S ribosomal protein L11; Validated; Region: rplK; PRK00140
862967003670	Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349
862967003671	23S rRNA interface [nucleotide binding]; other site
862967003672	L7/L12 interface [polypeptide binding]; other site
862967003673	putative thiostrepton binding site; other site
862967003674	L25 interface [polypeptide binding]; other site
862967003675	Protein of unknown function (DUF3397); Region: DUF3397; pfam11877
862967003676	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474
862967003677	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
862967003678	DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674
862967003679	FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580
862967003680	Ftsk gamma domain; Region: Ftsk_gamma; pfam09397
862967003681	PspC domain; Region: PspC; pfam04024
862967003682	Peptidyl-prolyl cis-trans isomerase (rotamase) - cyclophilin family [Posttranslational modification, protein turnover, chaperones]; Region: PpiB; COG0652
862967003683	active site
862967003684	ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488
862967003685	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
862967003686	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
862967003687	ABC transporter; Region: ABC_tran_2; pfam12848
862967003688	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
862967003689	Bacterial protein of unknown function (DUF898); Region: DUF898; cl01738
862967003690	5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Validated; Region: PRK05584
862967003691	5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Region: MTA/SAH-Nsdase; TIGR01704
862967003692	nudix-type nucleoside diphosphatase, YffH/AdpP family; Region: TIGR00052
862967003693	ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424
862967003694	dimer interface [polypeptide binding]; other site
862967003695	ADP-ribose binding site [chemical binding]; other site
862967003696	active site
862967003697	nudix motif; other site
862967003698	metal binding site [ion binding]; metal-binding site
862967003699	bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase; Provisional; Region: glmU; PRK14354
862967003700	N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540
862967003701	Substrate binding site; other site
862967003702	Mg++ binding site; other site
862967003703	N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353
862967003704	active site
862967003705	substrate binding site [chemical binding]; other site
862967003706	CoA binding site [chemical binding]; other site
862967003707	ASC-1 homology domain, subfamily similar to Enterococcus faecalis Ef3133. The ASCH domain, a small beta-barrel domain found in all three kingdoms of life, resembles the RNA-binding PUA domain and may also interact with RNA. ASCH has been proposed to...; Region: ASCH_Ef3133_like; cd06553
862967003708	GNAT acetyltransferase; Region: GNAT_acetyltran; pfam12746
862967003709	3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK06550
862967003710	classical (c) SDRs; Region: SDR_c; cd05233
862967003711	NAD(P) binding site [chemical binding]; other site
862967003712	active site
862967003713	Protein of unknown function (DUF2829); Region: DUF2829; pfam11195
862967003714	Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea.  CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458
862967003715	DNA-binding site [nucleotide binding]; DNA binding site
862967003716	RNA-binding motif; other site
862967003717	hypothetical protein; Provisional; Region: PRK09273
862967003718	Ribose/Galactose Isomerase; Region: LacAB_rpiB; pfam02502
862967003719	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
862967003720	Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583
862967003721	Acetyltransferases [General function prediction only]; Region: RimI; COG0456
862967003722	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
862967003723	Coenzyme A binding pocket [chemical binding]; other site
862967003724	amino acid transporter; Region: 2A0306; TIGR00909
862967003725	C-terminus of AA_permease; Region: AA_permease_C; pfam13906
862967003726	FtsX-like permease family; Region: FtsX; pfam02687
862967003727	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
862967003728	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
862967003729	Walker A/P-loop; other site
862967003730	ATP binding site [chemical binding]; other site
862967003731	Q-loop/lid; other site
862967003732	ABC transporter signature motif; other site
862967003733	Walker B; other site
862967003734	D-loop; other site
862967003735	H-loop/switch region; other site
862967003736	Protein of unknown function (DUF3021); Region: DUF3021; pfam11457
862967003737	LytTr DNA-binding domain; Region: LytTR; smart00850
862967003738	ABC-2 type transporter; Region: ABC2_membrane; cl17235
862967003739	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
862967003740	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
862967003741	Walker A/P-loop; other site
862967003742	ATP binding site [chemical binding]; other site
862967003743	Q-loop/lid; other site
862967003744	ABC transporter signature motif; other site
862967003745	Walker B; other site
862967003746	D-loop; other site
862967003747	H-loop/switch region; other site
862967003748	Domain of unknown function (DUF4162); Region: DUF4162; pfam13732
862967003749	FtsX-like permease family; Region: FtsX; pfam02687
862967003750	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
862967003751	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
862967003752	Walker A/P-loop; other site
862967003753	ATP binding site [chemical binding]; other site
862967003754	Q-loop/lid; other site
862967003755	ABC transporter signature motif; other site
862967003756	Walker B; other site
862967003757	D-loop; other site
862967003758	H-loop/switch region; other site
862967003759	TraX protein; Region: TraX; cl05434
862967003760	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
862967003761	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
862967003762	ATP binding site [chemical binding]; other site
862967003763	Mg2+ binding site [ion binding]; other site
862967003764	G-X-G motif; other site
862967003765	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
862967003766	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
862967003767	active site
862967003768	phosphorylation site [posttranslational modification]
862967003769	intermolecular recognition site; other site
862967003770	dimerization interface [polypeptide binding]; other site
862967003771	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
862967003772	DNA binding site [nucleotide binding]
862967003773	Lipase.  Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is "interfacial activation", the process of...; Region: Lipase; cd00741
862967003774	nucleophilic elbow; other site
862967003775	catalytic triad; other site
862967003776	methionyl-tRNA synthetase; Reviewed; Region: PRK12267
862967003777	catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814
862967003778	active site
862967003779	HIGH motif; other site
862967003780	KMSKS motif; other site
862967003781	Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957
862967003782	tRNA binding surface [nucleotide binding]; other site
862967003783	anticodon binding site; other site
862967003784	Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170
862967003785	tRNA-binding-domain-containing Escherichia coli methionyl-tRNA synthetase (EcMetRS)-like proteins.  This family includes EcMetRS and Aquifex aeolicus Trbp111 (AaTrbp111). This domain has general tRNA binding properties.  MetRS aminoacylates methionine...; Region: tRNA_bind_EcMetRS_like; cd02800
862967003786	G4 box; other site
862967003787	dimer interface [polypeptide binding]; other site
862967003788	putative tRNA-binding site [nucleotide binding]; other site
862967003789	Sugar efflux transporter for intercellular exchange; Region: MtN3_slv; pfam03083
862967003790	Predicted membrane protein [Function unknown]; Region: COG2323
862967003791	Protein of unknown function (DUF3290); Region: DUF3290; pfam11694
862967003792	Protein of unknown function (DUF1648); Region: DUF1648; pfam07853
862967003793	SdpI/YhfL protein family; Region: SdpI; pfam13630
862967003794	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
862967003795	dimerization interface [polypeptide binding]; other site
862967003796	putative DNA binding site [nucleotide binding]; other site
862967003797	putative Zn2+ binding site [ion binding]; other site
862967003798	CAAX protease self-immunity; Region: Abi; pfam02517
862967003799	Human Ape1-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: Ape1-like_AP-endo; cd09087
862967003800	active site
862967003801	putative catalytic site [active]
862967003802	DNA binding site [nucleotide binding]
862967003803	putative phosphate binding site [ion binding]; other site
862967003804	metal binding site A [ion binding]; metal-binding site
862967003805	AP binding site [nucleotide binding]; other site
862967003806	metal binding site B [ion binding]; metal-binding site
862967003807	Bleomycin binding protein (BLMA) and similar proteins; BLMA confers bleomycin (Bm) resistance by directly binding to Bm; Region: BLMA_like; cd08349
862967003808	dimer interface [polypeptide binding]; other site
862967003809	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
862967003810	ligand binding site [chemical binding]; other site
862967003811	Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177
862967003812	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056
862967003813	minor groove reading motif; other site
862967003814	helix-hairpin-helix signature motif; other site
862967003815	substrate binding pocket [chemical binding]; other site
862967003816	active site
862967003817	Arsenate Reductase (ArsC) family, unknown subfamily; uncharacterized proteins containing a CXXC motif with similarity to thioredoxin (TRX)-fold arsenic reductases, ArsC. Proteins containing a redox active CXXC motif like TRX and glutaredoxin (GRX)...; Region: ArsC_like; cd03036
862967003818	putative ArsC-like catalytic residues; other site
862967003819	putative TRX-like catalytic residues [active]
862967003820	Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350
862967003821	6-O-methylguanine DNA methyltransferase, ribonuclease-like domain; Region: Methyltransf_1N; pfam02870
862967003822	The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445
862967003823	DNA binding site [nucleotide binding]
862967003824	active site
862967003825	Predicted methyltransferases [General function prediction only]; Region: COG0313
862967003826	Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648
862967003827	putative SAM binding site [chemical binding]; other site
862967003828	putative homodimer interface [polypeptide binding]; other site
862967003829	DNA replication intiation control protein YabA; Reviewed; Region: PRK13169
862967003830	DNA polymerase III subunit delta'; Validated; Region: PRK07276
862967003831	DNA polymerase III subunit delta'; Validated; Region: PRK08485
862967003832	thymidylate kinase; Validated; Region: tmk; PRK00698
862967003833	Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672
862967003834	TMP-binding site; other site
862967003835	ATP-binding site [chemical binding]; other site
862967003836	Uncharacterized conserved protein [Function unknown]; Region: COG1284
862967003837	Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588
862967003838	Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588
862967003839	Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035
862967003840	FOG: CBS domain [General function prediction only]; Region: COG0517
862967003841	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in  the acetoin utilization proteins in bacteria. Acetoin is a product of fermentative metabolism in many prokaryotic and eukaryotic microorganisms.  They produce...; Region: CBS_pair_ACT_assoc2; cd04585
862967003842	ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cd02116
862967003843	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410
862967003844	ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224
862967003845	Walker A/P-loop; other site
862967003846	ATP binding site [chemical binding]; other site
862967003847	Q-loop/lid; other site
862967003848	ABC transporter signature motif; other site
862967003849	Walker B; other site
862967003850	D-loop; other site
862967003851	H-loop/switch region; other site
862967003852	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411
862967003853	ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219
862967003854	Walker A/P-loop; other site
862967003855	ATP binding site [chemical binding]; other site
862967003856	Q-loop/lid; other site
862967003857	ABC transporter signature motif; other site
862967003858	Walker B; other site
862967003859	D-loop; other site
862967003860	H-loop/switch region; other site
862967003861	ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177
862967003862	Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581
862967003863	TM-ABC transporter signature motif; other site
862967003864	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
862967003865	Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582
862967003866	TM-ABC transporter signature motif; other site
862967003867	ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683
862967003868	Type I periplasmic ligand-binding domain of uncharacterized ABC (Atpase Binding Cassette)-type active transport systems that are predicted to be involved in uptake of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_ligand_binding_like_12; cd06347
862967003869	putative ligand binding site [chemical binding]; other site
862967003870	hypothetical protein; Provisional; Region: PRK02302
862967003871	Clp protease; Region: CLP_protease; pfam00574
862967003872	Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017
862967003873	oligomer interface [polypeptide binding]; other site
862967003874	active site residues [active]
862967003875	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
862967003876	active site
862967003877	magnesium-transporting ATPase MgtA; Provisional; Region: PRK10517
862967003878	Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; pfam00690
862967003879	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
862967003880	Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246
862967003881	Soluble P-type ATPase [General function prediction only]; Region: COG4087
862967003882	Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689
862967003883	Bifunctional PLP-dependent enzyme with beta-cystathionase and maltose regulon repressor activities [Amino acid transport and metabolism]; Region: MalY; COG1168
862967003884	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
862967003885	pyridoxal 5'-phosphate binding site [chemical binding]; other site
862967003886	homodimer interface [polypeptide binding]; other site
862967003887	catalytic residue [active]
862967003888	Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244
862967003889	Stage V sporulation protein B, also known as Stage III sporulation protein F, and related proteins; Region: MATE_SpoVB_like; cd13124
862967003890	UDP-N-acetylmuramoylalanyl-D-glutamate--L-lysine ligase; Provisional; Region: PRK14022
862967003891	Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225
862967003892	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
862967003893	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
862967003894	Domain of unknown function (DUF1803); Region: DUF1803; pfam08820
862967003895	Domain of unknown function (DUF1803); Region: DUF1803; pfam08820
862967003896	Orthopoxvirus protein of unknown function (DUF830); Region: DUF830; cl13998
862967003897	putative manganese-dependent inorganic pyrophosphatase; Provisional; Region: PRK05427
862967003898	DHH family; Region: DHH; pfam01368
862967003899	DHHA2 domain; Region: DHHA2; pfam02833
862967003900	pyruvate formate-lyase 1-activating enzyme; Region: PFLA; TIGR02493
862967003901	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
862967003902	FeS/SAM binding site; other site
862967003903	YhcR_OBF_like: A subfamily of OB-fold domains similar to the OB folds of Bacillus subtilis YhcR. YhcR is a sugar-nonspecific nuclease, which is active in the presence of Ca2+ and Mn2+. It cleaves RNA endonucleolytically, producing 3'-monophosphate...; Region: YhcR_OBF_like; cd04486
862967003904	generic binding surface I; other site
862967003905	generic binding surface II; other site
862967003906	Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490
862967003907	putative catalytic site [active]
862967003908	putative metal binding site [ion binding]; other site
862967003909	putative phosphate binding site [ion binding]; other site
862967003910	alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403
862967003911	Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333
862967003912	Ca binding site [ion binding]; other site
862967003913	active site
862967003914	catalytic site [active]
862967003915	PTS system, trehalose-specific IIBC component; Region: PTS-IIBC-Tre; TIGR01992
862967003916	PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212
862967003917	active site turn [active]
862967003918	phosphorylation site [posttranslational modification]
862967003919	Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263
862967003920	Phosphotransferase system IIA components [Carbohydrate transport and metabolism]; Region: NagE; COG2190
862967003921	HPr interaction site; other site
862967003922	glycerol kinase (GK) interaction site [polypeptide binding]; other site
862967003923	active site
862967003924	phosphorylation site [posttranslational modification]
862967003925	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
862967003926	DNA-binding site [nucleotide binding]; DNA binding site
862967003927	trehalose operon repressor, B. subtilis-type; Region: trehalos_R_Bsub; TIGR02404
862967003928	UTRA domain; Region: UTRA; pfam07702
862967003929	Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253
862967003930	Domain of unknown function DUF21; Region: DUF21; pfam01595
862967003931	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590
862967003932	Transporter associated domain; Region: CorC_HlyC; smart01091
862967003933	Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and...; Region: PEPCK_HprK; cl00270
862967003934	active site
862967003935	metal-binding site [ion binding]
862967003936	active site
862967003937	nucleotide-binding site [chemical binding]; other site
862967003938	nucleotide-binding site [chemical binding]; other site
862967003939	Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628
862967003940	Domain of unknown function DUF20; Region: UPF0118; pfam01594
862967003941	isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK05743
862967003942	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
862967003943	active site
862967003944	HIGH motif; other site
862967003945	nucleotide binding site [chemical binding]; other site
862967003946	catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818
862967003947	active site
862967003948	KMSKS motif; other site
862967003949	Anticodon-binding domain of bacterial and eukaryotic mitochondrial isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_BEm; cd07960
862967003950	tRNA binding surface [nucleotide binding]; other site
862967003951	anticodon binding site; other site
862967003952	Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827
862967003953	DivIVA protein; Region: DivIVA; pfam05103
862967003954	DivIVA domain; Region: DivI1A_domain; TIGR03544
862967003955	Uncharacterized conserved protein, contains S4-like domain [Function unknown]; Region: COG2302
862967003956	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
862967003957	RNA binding surface [nucleotide binding]; other site
862967003958	YGGT family; Region: YGGT; pfam02325
862967003959	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1799
862967003960	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, YBL036c-like proteins; Region: PLPDE_III_YBL036c_like; cd00635
862967003961	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
862967003962	catalytic residue [active]
862967003963	cell division protein FtsZ; Validated; Region: PRK09330
862967003964	FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes.  FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201
862967003965	nucleotide binding site [chemical binding]; other site
862967003966	SulA interaction site; other site
862967003967	Cell division ATPase FtsA [Cell division and chromosome partitioning]; Region: ftsA; COG0849
862967003968	Cell division protein FtsA; Region: FtsA; smart00842
862967003969	Cell division protein FtsA; Region: FtsA; pfam14450
862967003970	Domain of unknown function (DUF3484); Region: DUF3484; pfam11983
862967003971	POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478
862967003972	Cell division protein FtsQ; Region: FtsQ; pfam03799
862967003973	undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726
862967003974	MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785
862967003975	active site
862967003976	homodimer interface [polypeptide binding]; other site
862967003977	UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK02472
862967003978	Alanine dehydrogenase/PNT, C-terminal domain; Region: AlaDh_PNT_C; smart01002
862967003979	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
862967003980	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
862967003981	Protein of unknown function (DUF3165); Region: DUF3165; pfam11364
862967003982	Predicted membrane GTPase involved in stress response [Signal transduction mechanisms]; Region: TypA; COG1217
862967003983	Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891
862967003984	G1 box; other site
862967003985	putative GEF interaction site [polypeptide binding]; other site
862967003986	GTP/Mg2+ binding site [chemical binding]; other site
862967003987	Switch I region; other site
862967003988	G2 box; other site
862967003989	G3 box; other site
862967003990	Switch II region; other site
862967003991	G4 box; other site
862967003992	G5 box; other site
862967003993	BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu.  BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691
862967003994	BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants.  BipA is a highly...; Region: BipA_TypA_C; cd03710
862967003995	16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187
862967003996	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
862967003997	RNA binding surface [nucleotide binding]; other site
862967003998	Pseudouridine synthase, Escherichia coli RsuA like; Region: PseudoU_synth_RsuA; cd02553
862967003999	active site
862967004000	uracil binding [chemical binding]; other site
862967004001	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158
862967004002	active site residue [active]
862967004003	DNA-binding ferritin-like protein (oxidative damage protectant) [Inorganic ion transport and metabolism]; Region: Dps; COG0783
862967004004	DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043
862967004005	dimerization interface [polypeptide binding]; other site
862967004006	DPS ferroxidase diiron center [ion binding]; other site
862967004007	ion pore; other site
862967004008	Type II secretory pathway, prepilin signal peptidase PulO and related peptidases [Cell motility and secretion / Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: PulO; COG1989
862967004009	Bacterial Peptidase A24 N-terminal domain; Region: DiS_P_DiS; pfam06750
862967004010	VanZ like family; Region: VanZ; pfam04892
862967004011	ribosomal RNA large subunit methyltransferase N; Provisional; Region: PRK14455
862967004012	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
862967004013	FeS/SAM binding site; other site
862967004014	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4470
862967004015	Predicted secreted protein containing a PDZ domain [Signal transduction mechanisms]; Region: SdrC; COG3480
862967004016	PDZ domain, also called DHR (Dlg homologous region) or GLGF (after a conserved sequence motif). Many PDZ domains bind C-terminal polypeptides, though binding to internal (non-C-terminal) polypeptides and even to lipids has been demonstrated; Region: PDZ; cl00117
862967004017	protein binding site [polypeptide binding]; other site
862967004018	phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168
862967004019	Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163
862967004020	active site
862967004021	(T/H)XGH motif; other site
862967004022	Conserved hypothetical protein 95; Region: Cons_hypoth95; pfam03602
862967004023	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
862967004024	S-adenosylmethionine binding site [chemical binding]; other site
862967004025	RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY,  is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552
862967004026	30S subunit binding site; other site
862967004027	Predicted amidophosphoribosyltransferases [General function prediction only]; Region: ComFC; COG1040
862967004028	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
862967004029	active site
862967004030	Superfamily II DNA/RNA helicase required for DNA uptake (late competence protein) [DNA replication, recombination, and repair]; Region: comFA; COG4098
862967004031	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
862967004032	ATP binding site [chemical binding]; other site
862967004033	putative Mg++ binding site [ion binding]; other site
862967004034	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
862967004035	nucleotide binding region [chemical binding]; other site
862967004036	ATP-binding site [chemical binding]; other site
862967004037	Uncharacterized conserved protein [Function unknown]; Region: COG1739
862967004038	Uncharacterized protein family UPF0029; Region: UPF0029; pfam01205
862967004039	Domain of unknown function (DUF1949); Region: DUF1949; pfam09186
862967004040	Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031
862967004041	CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561
862967004042	dimer interface [polypeptide binding]; other site
862967004043	pyridoxal 5'-phosphate binding site [chemical binding]; other site
862967004044	catalytic residue [active]
862967004045	valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729
862967004046	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
862967004047	active site
862967004048	HIGH motif; other site
862967004049	nucleotide binding site [chemical binding]; other site
862967004050	Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603
862967004051	catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817
862967004052	active site
862967004053	KMSKS motif; other site
862967004054	Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962
862967004055	tRNA binding surface [nucleotide binding]; other site
862967004056	anticodon binding site; other site
862967004057	Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458
862967004058	Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670
862967004059	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
862967004060	2'-5' RNA ligase [Translation, ribosomal structure and biogenesis]; Region: LigT; COG1514
862967004061	Domain of unknown function (DUF1912); Region: DUF1912; pfam08930
862967004062	Uncharacterized conserved protein [Function unknown]; Region: COG2461
862967004063	Family of unknown function (DUF438); Region: DUF438; pfam04282
862967004064	Hemerythrin HHE cation binding domain; Region: Hemerythrin; pfam01814
862967004065	Domain of unknown function (DUF1858); Region: DUF1858; pfam08984
862967004066	TRAM domain; Region: TRAM; cl01282
862967004067	SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase [Translation, ribosomal structure and biogenesis]; Region: TrmA; COG2265
862967004068	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
862967004069	S-adenosylmethionine binding site [chemical binding]; other site
862967004070	Phosphotransferase enzyme family; Region: APH; pfam01636
862967004071	Aminoglycoside 3'-phosphotransferase (APH). The APH subfamily is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs), RIO kinases, actin-fragmin...; Region: APH; cd05150
862967004072	active site
862967004073	ATP binding site [chemical binding]; other site
862967004074	antibiotic binding site [chemical binding]; other site
862967004075	recombination regulator RecX; Provisional; Region: recX; PRK14135
862967004076	hypothetical protein; Provisional; Region: PRK13662
862967004077	Staphylococcal protein of unknown function (DUF960); Region: DUF960; pfam06124
862967004078	Predicted RNA binding protein (contains ribosomal protein S1 domain) [Translation, ribosomal structure and biogenesis]; Region: VacB; COG1098
862967004079	hypothetical protein; Provisional; Region: PRK07252
862967004080	RNA binding site [nucleotide binding]; other site
862967004081	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
862967004082	haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282
862967004083	active site
862967004084	motif I; other site
862967004085	motif II; other site
862967004086	haloacid dehalogenase-like hydrolase; Region: HAD; cl17202
862967004087	cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317
862967004088	active site
862967004089	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
862967004090	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
862967004091	active site
862967004092	phosphorylation site [posttranslational modification]
862967004093	intermolecular recognition site; other site
862967004094	dimerization interface [polypeptide binding]; other site
862967004095	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
862967004096	DNA binding residues [nucleotide binding]
862967004097	dimerization interface [polypeptide binding]; other site
862967004098	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
862967004099	Histidine kinase; Region: HisKA_3; pfam07730
862967004100	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
862967004101	ATP binding site [chemical binding]; other site
862967004102	Mg2+ binding site [ion binding]; other site
862967004103	G-X-G motif; other site
862967004104	Predicted membrane protein [Function unknown]; Region: COG4758
862967004105	Cell wall-active antibiotics response protein (DUF2154); Region: DUF2154; pfam09922
862967004106	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
862967004107	Catalytic domain of Protein Kinases; Region: PKc; cd00180
862967004108	active site
862967004109	ATP binding site [chemical binding]; other site
862967004110	substrate binding site [chemical binding]; other site
862967004111	activation loop (A-loop); other site
862967004112	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2815
862967004113	PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577
862967004114	PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577
862967004115	PASTA domain. This domain is found at the C-termini of several Penicillin-binding proteins (PBPs) and bacterial serine/threonine kinases. It is a small globular fold consisting of 3 beta-sheets and an alpha-helix. The name PASTA is derived from PBP and...; Region: PASTA; cl02768
862967004116	Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143
862967004117	active site
862967004118	16S rRNA methyltransferase B; Provisional; Region: PRK14902
862967004119	NusB family; Region: NusB; pfam01029
862967004120	putative RNA binding site [nucleotide binding]; other site
862967004121	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
862967004122	S-adenosylmethionine binding site [chemical binding]; other site
862967004123	methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005
862967004124	Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646
862967004125	putative active site [active]
862967004126	substrate binding site [chemical binding]; other site
862967004127	putative cosubstrate binding site; other site
862967004128	catalytic site [active]
862967004129	C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704
862967004130	substrate binding site [chemical binding]; other site
862967004131	Primosomal protein N' (replication factor Y) - superfamily II helicase [DNA replication, recombination, and repair]; Region: PriA; COG1198
862967004132	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
862967004133	ATP binding site [chemical binding]; other site
862967004134	putative Mg++ binding site [ion binding]; other site
862967004135	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
862967004136	ATP-binding site [chemical binding]; other site
862967004137	DNA-directed RNA polymerase subunit omega; Reviewed; Region: rpoZ; PRK00392
862967004138	Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194
862967004139	Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071
862967004140	catalytic site [active]
862967004141	G-X2-G-X-G-K; other site
862967004142	hypothetical protein; Provisional; Region: PRK00106
862967004143	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
862967004144	Zn2+ binding site [ion binding]; other site
862967004145	Mg2+ binding site [ion binding]; other site
862967004146	S-ribosylhomocysteinase; Provisional; Region: PRK02260
862967004147	ORF6N domain; Region: ORF6N; pfam10543
862967004148	Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961
862967004149	Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cl02788
862967004150	catalytic residues [active]
862967004151	Recombinase; Region: Recombinase; pfam07508
862967004152	Recombinase zinc beta ribbon domain; Region: Zn_ribbon_recom; pfam13408
862967004153	Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961
862967004154	Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cl02788
862967004155	catalytic residues [active]
862967004156	catalytic nucleophile [active]
862967004157	Recombinase; Region: Recombinase; pfam07508
862967004158	Recombinase zinc beta ribbon domain; Region: Zn_ribbon_recom; pfam13408
862967004159	Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961
862967004160	Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cl02788
862967004161	catalytic residues [active]
862967004162	catalytic nucleophile [active]
862967004163	Recombinase; Region: Recombinase; pfam07508
862967004164	Recombinase zinc beta ribbon domain; Region: Zn_ribbon_recom; pfam13408
862967004165	Domain of unknown function (DUF4368); Region: DUF4368; pfam14287
862967004166	Predicted Fe-S oxidoreductases [General function prediction only]; Region: COG0535
862967004167	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
862967004168	FeS/SAM binding site; other site
862967004169	radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085
862967004170	ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122
862967004171	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
862967004172	Walker A/P-loop; other site
862967004173	ATP binding site [chemical binding]; other site
862967004174	Q-loop/lid; other site
862967004175	ABC transporter signature motif; other site
862967004176	Walker B; other site
862967004177	D-loop; other site
862967004178	H-loop/switch region; other site
862967004179	Predicted Fe-S oxidoreductases [General function prediction only]; Region: COG0535
862967004180	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
862967004181	FeS/SAM binding site; other site
862967004182	radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085
862967004183	Bacteriocin subtilosin A; Region: Subtilosin_A; pfam11420
862967004184	Relaxase/Mobilisation nuclease domain; Region: Relaxase; pfam03432
862967004185	Replication protein A, class 2b aminoacyl-tRNA synthetases, and related proteins with oligonucleotide/oligosaccharide (OB) fold; Region: RPA_2b-aaRSs_OBF_like; cl09930
862967004186	generic binding surface II; other site
862967004187	generic binding surface I; other site
862967004188	Protein of unknown function (DUF2958); Region: DUF2958; pfam11171
862967004189	Methyltransferase domain; Region: Methyltransf_26; pfam13659
862967004190	Adenine-specific DNA methylase [DNA replication, recombination, and repair]; Region: COG0827
862967004191	DNA methylase [Transcription / DNA replication, recombination, and repair]; Region: COG4646
862967004192	DEAD-like helicases superfamily; Region: DEXDc; smart00487
862967004193	DNA methylase [Transcription / DNA replication, recombination, and repair]; Region: COG4646
862967004194	helicase superfamily c-terminal domain; Region: HELICc; smart00490
862967004195	TATA element modulatory factor 1 TATA binding; Region: TMF_TATA_bd; pfam12325
862967004196	Transposase; Region: DEDD_Tnp_IS110; pfam01548
862967004197	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547
862967004198	Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371
862967004199	DNA topoisomerase III; Provisional; Region: PRK07726
862967004200	TOPRIM_TopoIA_TopoIII: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to topoisomerase III. Type IA DNA topoisomerases remove (relax) negative supercoils in the DNA by: cleaving...; Region: TOPRIM_TopoIA_TopoIII; cd03362
862967004201	active site
862967004202	putative interdomain interaction site [polypeptide binding]; other site
862967004203	putative metal-binding site [ion binding]; other site
862967004204	putative nucleotide binding site [chemical binding]; other site
862967004205	DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186
862967004206	domain I; other site
862967004207	DNA binding groove [nucleotide binding]
862967004208	phosphate binding site [ion binding]; other site
862967004209	domain II; other site
862967004210	domain III; other site
862967004211	nucleotide binding site [chemical binding]; other site
862967004212	catalytic site [active]
862967004213	domain IV; other site
862967004214	Domain of unknown function (DUF4366); Region: DUF4366; pfam14283
862967004215	Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791
862967004216	NlpC/P60 family; Region: NLPC_P60; pfam00877
862967004217	AAA-like domain; Region: AAA_10; pfam12846
862967004218	PrgI family protein; Region: PrgI; pfam12666
862967004219	Maff2 family; Region: Maff2; pfam12750
862967004220	Replication protein A, class 2b aminoacyl-tRNA synthetases, and related proteins with oligonucleotide/oligosaccharide (OB) fold; Region: RPA_2b-aaRSs_OBF_like; cl09930
862967004221	generic binding surface II; other site
862967004222	generic binding surface I; other site
862967004223	Type IV secretory system Conjugative DNA transfer; Region: T4SS-DNA_transf; pfam02534
862967004224	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
862967004225	Walker A motif; other site
862967004226	ATP binding site [chemical binding]; other site
862967004227	Walker B motif; other site
862967004228	Prophage antirepressor [Transcription]; Region: COG3617
862967004229	BRO family, N-terminal domain; Region: Bro-N; smart01040
862967004230	Phage antirepressor protein KilAC domain; Region: ANT; pfam03374
862967004231	Protein of unknown function (DUF3801); Region: DUF3801; pfam12687
862967004232	hypothetical protein; Validated; Region: PRK08116
862967004233	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
862967004234	Walker A motif; other site
862967004235	ATP binding site [chemical binding]; other site
862967004236	Walker B motif; other site
862967004237	Replication initiator protein A (RepA) N-terminus; Region: RepA_N; pfam06970
862967004238	alkyl hydroperoxide reductase subunit F; Provisional; Region: PRK15317
862967004239	Alkyl hydroperoxide reductase F subunit (AhpF) N-terminal domain (NTD) family, N-terminal TRX-fold subdomain; AhpF is a homodimeric flavoenzyme which catalyzes the NADH-dependent reduction of the peroxiredoxin AhpC, which in turn catalyzes the reduction...; Region: AhpF_NTD_N; cd02974
862967004240	catalytic residue [active]
862967004241	TRX-GRX-like family, Alkyl hydroperoxide reductase F subunit (AhpF) N-terminal domain (NTD) subfamily, C-terminal TRX-fold subdomain; AhpF is a homodimeric flavoenzyme which catalyzes the NADH-dependent reduction of the peroxiredoxin AhpC, which then...; Region: AhpF_NTD_C; cd03026
862967004242	catalytic residues [active]
862967004243	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
862967004244	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
862967004245	peroxiredoxin; Region: AhpC; TIGR03137
862967004246	Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015
862967004247	dimer interface [polypeptide binding]; other site
862967004248	decamer (pentamer of dimers) interface [polypeptide binding]; other site
862967004249	catalytic triad [active]
862967004250	peroxidatic and resolving cysteines [active]
862967004251	Predicted N6-adenine-specific DNA methylase [DNA replication, recombination, and repair]; Region: COG0116
862967004252	THUMP domain associated with S-adenosylmethionine-dependent methyltransferases; Region: THUMP_AdoMetMT; cd11715
862967004253	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173
862967004254	cell division protein GpsB; Provisional; Region: PRK14127
862967004255	DivIVA domain; Region: DivI1A_domain; TIGR03544
862967004256	Holliday junction-specific endonuclease; Reviewed; Region: recU; PRK02234
862967004257	Transglycosylase; Region: Transgly; pfam00912
862967004258	penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074
862967004259	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760
862967004260	Peptidase C1B subfamily (MEROPS database nomenclature); composed of eukaryotic bleomycin hydrolases (BH) and bacterial aminopeptidases C (pepC). The proteins of this subfamily contain a large insert relative to the C1A peptidase (papain) subfamily. BH is...; Region: Peptidase_C1B; cd00585
862967004261	trimer interface [polypeptide binding]; other site
862967004262	active site
862967004263	G bulge; other site
862967004264	NAD synthase [Coenzyme metabolism]; Region: NadE; COG0171
862967004265	NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553
862967004266	homodimer interface [polypeptide binding]; other site
862967004267	NAD binding pocket [chemical binding]; other site
862967004268	ATP binding pocket [chemical binding]; other site
862967004269	Mg binding site [ion binding]; other site
862967004270	active-site loop [active]
862967004271	nicotinate phosphoribosyltransferase; Validated; Region: PRK09243
862967004272	Nicotinate phosphoribosyltransferase (NAPRTase), subgroup A. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting, reaction...; Region: NAPRTase_A; cd01570
862967004273	active site
862967004274	Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113
862967004275	thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292
862967004276	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
862967004277	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
862967004278	Protein of unknown function (DUF4059); Region: DUF4059; pfam13268
862967004279	ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126
862967004280	ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262
862967004281	Walker A/P-loop; other site
862967004282	ATP binding site [chemical binding]; other site
862967004283	Q-loop/lid; other site
862967004284	ABC transporter signature motif; other site
862967004285	Walker B; other site
862967004286	D-loop; other site
862967004287	H-loop/switch region; other site
862967004288	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
862967004289	dimer interface [polypeptide binding]; other site
862967004290	conserved gate region; other site
862967004291	putative PBP binding loops; other site
862967004292	ABC-ATPase subunit interface; other site
862967004293	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251
862967004294	DEAD-like helicases superfamily; Region: DEXDc; smart00487
862967004295	ATP binding site [chemical binding]; other site
862967004296	putative Mg++ binding site [ion binding]; other site
862967004297	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
862967004298	nucleotide binding region [chemical binding]; other site
862967004299	ATP-binding site [chemical binding]; other site
862967004300	D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: DacC; COG1686
862967004301	Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872
862967004302	Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; smart00936
862967004303	NifU homolog involved in Fe-S cluster formation [Energy production and conversion]; Region: IscU; COG0822
862967004304	Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664
862967004305	trimerization site [polypeptide binding]; other site
862967004306	active site
862967004307	Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520
862967004308	Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453
862967004309	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
862967004310	catalytic residue [active]
862967004311	Cysteine desulfurase activator SufB [Posttranslational modification, protein turnover, chaperones]; Region: SufB; COG0719
862967004312	FeS assembly protein SufD; Region: sufD; TIGR01981
862967004313	Cysteine desulfurase activator ATPase [Posttranslational modification, protein turnover, chaperones]; Region: sufC; COG0396
862967004314	ABC-type transport system involved in Fe-S cluster assembly, ATPase component; Region: ABC_FeS_Assembly; cd03217
862967004315	Walker A/P-loop; other site
862967004316	ATP binding site [chemical binding]; other site
862967004317	Q-loop/lid; other site
862967004318	ABC transporter signature motif; other site
862967004319	Walker B; other site
862967004320	D-loop; other site
862967004321	H-loop/switch region; other site
862967004322	UDP-N-acetylmuramyl pentapeptide phosphotransferase/UDP-N- acetylglucosamine-1-phosphate transferase [Cell envelope biogenesis, outer membrane]; Region: Rfe; COG0472
862967004323	This subfamily contains Escherichia coli WecA, Bacillus subtilis TagO and related proteins. WecA is an UDP-N-acetylglucosamine (GlcNAc):undecaprenyl-phosphate (Und-P) GlcNAc-1-phosphate transferase that catalyzes the formation of a phosphodiester bond...; Region: GT_WecA_like; cd06853
862967004324	Mg++ binding site [ion binding]; other site
862967004325	putative catalytic motif [active]
862967004326	adaptor protein; Provisional; Region: PRK02315
862967004327	undecaprenyl pyrophosphate phosphatase; Reviewed; Region: PRK00281
862967004328	Predicted membrane protein (DUF2207); Region: DUF2207; pfam09972
862967004329	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
862967004330	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
862967004331	substrate binding pocket [chemical binding]; other site
862967004332	membrane-bound complex binding site; other site
862967004333	hinge residues; other site
862967004334	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
862967004335	dimer interface [polypeptide binding]; other site
862967004336	conserved gate region; other site
862967004337	ABC-ATPase subunit interface; other site
862967004338	ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126
862967004339	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
862967004340	Walker A/P-loop; other site
862967004341	ATP binding site [chemical binding]; other site
862967004342	Q-loop/lid; other site
862967004343	ABC transporter signature motif; other site
862967004344	Walker B; other site
862967004345	D-loop; other site
862967004346	H-loop/switch region; other site
862967004347	A subgroup of the band 7 domain of flotillin (reggie) like proteins. This subgroup contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin.  Many of these band 7 domain-containing proteins are lipid raft-associated.  Individual...; Region: Band_7_4; cd03407
862967004348	HflK protein; Region: hflK; TIGR01933
862967004349	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
862967004350	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
862967004351	active site
862967004352	phosphorylation site [posttranslational modification]
862967004353	intermolecular recognition site; other site
862967004354	dimerization interface [polypeptide binding]; other site
862967004355	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
862967004356	DNA binding residues [nucleotide binding]
862967004357	dimerization interface [polypeptide binding]; other site
862967004358	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585
862967004359	Histidine kinase; Region: HisKA_3; pfam07730
862967004360	Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518
862967004361	ABC-2 type transporter; Region: ABC2_membrane; pfam01061
862967004362	ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842
862967004363	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
862967004364	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
862967004365	Walker A/P-loop; other site
862967004366	ATP binding site [chemical binding]; other site
862967004367	Q-loop/lid; other site
862967004368	ABC transporter signature motif; other site
862967004369	Walker B; other site
862967004370	D-loop; other site
862967004371	H-loop/switch region; other site
862967004372	DAK2 domain fusion protein YloV; Region: YloV; TIGR03599
862967004373	DAK2 domain; Region: Dak2; pfam02734
862967004374	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1302
862967004375	50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359
862967004376	Cell wall-active antibiotics response protein (DUF2154); Region: DUF2154; pfam09922
862967004377	LytTr DNA-binding domain; Region: LytTR; smart00850
862967004378	fructose-bisphosphate aldolase; Provisional; Region: PRK09197
862967004379	Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947
862967004380	intersubunit interface [polypeptide binding]; other site
862967004381	active site
862967004382	zinc binding site [ion binding]; other site
862967004383	Na+ binding site [ion binding]; other site
862967004384	GyrI-like small molecule binding domain; Region: GyrI-like; cl01368
862967004385	ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166
862967004386	The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504
862967004387	peptide binding site [polypeptide binding]; other site
862967004388	phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108
862967004389	Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852
862967004390	Mg++ binding site [ion binding]; other site
862967004391	putative catalytic motif [active]
862967004392	putative substrate binding site [chemical binding]; other site
862967004393	Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768
862967004394	Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717
862967004395	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905
862967004396	PASTA domain of PBP2x-like proteins, first repeat. Penicillin-binding proteins (PBPs) are the major targets for beta-lactam antibiotics, like penicillins and cephalosporins. Beta-lactam antibiotics specifically inhibit transpeptidase activity by...; Region: PASTA_Pbp2x-like_1; cd06576
862967004397	PASTA domain of PBP2x-like proteins, second repeat. Penicillin-binding proteins (PBPs) are the major targets for beta-lactam antibiotics, like penicillins and cephalosporins. Beta-lactam antibiotics specifically inhibit transpeptidase activity by...; Region: PASTA_Pbp2x-like_2; cd06575
862967004398	Protein required for the initiation of cell division [Cell division and chromosome partitioning]; Region: FtsL; COG4839
862967004399	Predicted S-adenosylmethionine-dependent methyltransferase involved in cell envelope biogenesis [Cell envelope biogenesis, outer membrane]; Region: COG0275
862967004400	MraW methylase family; Region: Methyltransf_5; pfam01795
862967004401	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
862967004402	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
862967004403	non-specific DNA binding site [nucleotide binding]; other site
862967004404	salt bridge; other site
862967004405	sequence-specific DNA binding site [nucleotide binding]; other site
862967004406	Trk-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: TrkG; COG0168
862967004407	potassium uptake protein, TrkH family; Region: 2a38; TIGR00933
862967004408	K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569
862967004409	TrkA-N domain; Region: TrkA_N; pfam02254
862967004410	TrkA-C domain; Region: TrkA_C; pfam02080
862967004411	hypothetical protein; Provisional; Region: PRK02539
862967004412	glycyl-tRNA synthetase subunit beta; Validated; Region: glyS; PRK01233
862967004413	Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020
862967004414	Class II Glycyl-tRNA synthetase (GlyRS) alpha subunit core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes and in arabidopsis. It is responsible for the...; Region: GlyRS_alpha_core; cd00733
862967004415	dimer interface [polypeptide binding]; other site
862967004416	motif 1; other site
862967004417	active site
862967004418	motif 2; other site
862967004419	motif 3; other site
862967004420	hypothetical protein; Provisional; Region: PRK02268
862967004421	Transcriptional regulators [Transcription]; Region: MarR; COG1846
862967004422	MarR family; Region: MarR_2; cl17246
862967004423	Ligand-binding SRPBCC domain of Streptococcus mutans Smu.440 and related proteins; Region: SRPBCC_Smu440-like; cd08862
862967004424	putative hydrophobic ligand binding site [chemical binding]; other site
862967004425	Gram-positive signal peptide, YSIRK family; Region: YSIRK_signal; TIGR01168
862967004426	Peptidase S8 family domain in Streptococcal C5a peptidases; Region: Peptidases_S8_C5a_Peptidase; cd07475
862967004427	putative active site [active]
862967004428	catalytic triad [active]
862967004429	PA_C5a_like: Protease-associated domain containing proteins like Streptococcus pyogenes C5a peptidase. This group contains various PA domain-containing proteins similar to S. pyogenes C5a, including, i) Vpr, a minor extracellular serine protease from...; Region: PA_C5a_like; cd02133
862967004430	PA/protease domain interface [polypeptide binding]; other site
862967004431	putative integrin binding motif; other site
862967004432	Peptidase S8 family domain in Streptococcal C5a peptidases; Region: Peptidases_S8_C5a_Peptidase; cd07475
862967004433	Fn3-like domain (DUF1034); Region: DUF1034; pfam06280
862967004434	C-terminal domain of CHU protein family; Region: CHU_C; cl17875
862967004435	N-acetylglucosamine-6-phosphate deacetylase [Carbohydrate transport and metabolism]; Region: NagA; COG1820
862967004436	N-acetylglucosamine-6-phosphate deacetylase, NagA, catalyzes the hydrolysis of the N-acetyl group of N-acetyl-glucosamine-6-phosphate (GlcNAc-6-P) to glucosamine 6-phosphate and acetate. This is the first committed step in the biosynthetic pathway to...; Region: NagA; cd00854
862967004437	active site
862967004438	dimer interface [polypeptide binding]; other site
862967004439	Na+/phosphate symporter [Inorganic ion transport and metabolism]; Region: NptA; COG1283
862967004440	Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690
862967004441	Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690
862967004442	PhoU domain; Region: PhoU; pfam01895
862967004443	PhoU domain; Region: PhoU; pfam01895
862967004444	ribosome-binding factor A; Validated; Region: rbfA; PRK00521
862967004445	Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760
862967004446	translation initiation factor IF-2; Validated; Region: infB; PRK05306
862967004447	Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760
862967004448	Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887
862967004449	G1 box; other site
862967004450	putative GEF interaction site [polypeptide binding]; other site
862967004451	GTP/Mg2+ binding site [chemical binding]; other site
862967004452	Switch I region; other site
862967004453	G2 box; other site
862967004454	G3 box; other site
862967004455	Switch II region; other site
862967004456	G4 box; other site
862967004457	G5 box; other site
862967004458	This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702
862967004459	Translation-initiation factor 2; Region: IF-2; pfam11987
862967004460	mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692
862967004461	hypothetical protein; Provisional; Region: PRK07283
862967004462	Ylxr homologs; group of conserved hypothetical bacterial proteins of unknown function; structure revealed putative RNA binding cleft; proteins are encoded by an operon that includes other proteins involved in transcription and/or translation; Region: YlxR; cd00279
862967004463	putative RNA binding cleft [nucleotide binding]; other site
862967004464	transcription elongation factor NusA; Provisional; Region: nusA; PRK12327
862967004465	NusA N-terminal domain; Region: NusA_N; pfam08529
862967004466	S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455
862967004467	RNA binding site [nucleotide binding]; other site
862967004468	homodimer interface [polypeptide binding]; other site
862967004469	NusA-like KH domain; Region: KH_5; pfam13184
862967004470	NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134
862967004471	G-X-X-G motif; other site
862967004472	ribosome maturation protein RimP; Reviewed; Region: PRK00092
862967004473	Bacillus subtilis YxlS-like, C-terminal domain; Region: YlxS_C; cd01734
862967004474	putative oligomer interface [polypeptide binding]; other site
862967004475	putative RNA binding site [nucleotide binding]; other site
862967004476	Nodulin-21 and CCC1-related protein family; Region: Nodulin-21_like_1; cd02432
862967004477	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
862967004478	S-adenosylmethionine binding site [chemical binding]; other site
862967004479	Thiamine kinase and related kinases [Coenzyme transport and metabolism]; Region: ycfN; COG0510
862967004480	Phosphotransferase enzyme family; Region: APH; pfam01636
862967004481	substrate binding site [chemical binding]; other site
862967004482	Bacterial ABC transporter protein EcsB; Region: EcsB; pfam05975
862967004483	ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122
862967004484	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
862967004485	Walker A/P-loop; other site
862967004486	ATP binding site [chemical binding]; other site
862967004487	Q-loop/lid; other site
862967004488	ABC transporter signature motif; other site
862967004489	Walker B; other site
862967004490	D-loop; other site
862967004491	H-loop/switch region; other site
862967004492	HINT (histidine triad nucleotide-binding protein) subgroup: Members of this CD belong to the superfamily of histidine triad hydrolases that act on alpha-phosphate of ribonucleotides. This subgroup includes members from all three forms of cellular life; Region: HINT_subgroup; cd01277
862967004493	HIT family signature motif; other site
862967004494	catalytic residue [active]
862967004495	Transcriptional regulator [Transcription]; Region: LytR; COG1316
862967004496	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
862967004497	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
862967004498	Coenzyme A binding pocket [chemical binding]; other site
862967004499	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
862967004500	Predicted ATPase or kinase [General function prediction only]; Region: COG0802
862967004501	Xanthine/uracil/vitamin C permease [Nucleotide transport and    metabolism]; Region: COG2252
862967004502	Protein of unknown function (DUF1361); Region: DUF1361; pfam07099
862967004503	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
862967004504	haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282
862967004505	active site
862967004506	motif I; other site
862967004507	motif II; other site
862967004508	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cl17915
862967004509	ethanol-active dehydrogenase/acetaldehyde-active reductase; Provisional; Region: PRK09422
862967004510	Cinnamyl alcohol dehydrogenases (CAD); Region: CAD3; cd08297
862967004511	NAD binding site [chemical binding]; other site
862967004512	substrate binding site [chemical binding]; other site
862967004513	catalytic Zn binding site [ion binding]; other site
862967004514	tetramer interface [polypeptide binding]; other site
862967004515	structural Zn binding site [ion binding]; other site
862967004516	PTS system mannose-specific transporter subunits IIAB; Provisional; Region: PRK15088
862967004517	PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006
862967004518	active pocket/dimerization site; other site
862967004519	active site
862967004520	phosphorylation site [posttranslational modification]
862967004521	PTS_IIB, PTS system, Mannose/sorbose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_man; cd00001
862967004522	active site
862967004523	phosphorylation site [posttranslational modification]
862967004524	PTS system mannose-specific transporter subunit IIC; Provisional; Region: PRK15065
862967004525	Phosphotransferase system, mannose/fructose/N-acetylgalactosamine-specific component IID [Carbohydrate transport and metabolism]; Region: ManZ; COG3716
862967004526	Domain of unknown function (DUF956); Region: DUF956; cl01917
862967004527	seryl-tRNA synthetase; Provisional; Region: PRK05431
862967004528	Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403
862967004529	Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770
862967004530	dimer interface [polypeptide binding]; other site
862967004531	active site
862967004532	motif 1; other site
862967004533	motif 2; other site
862967004534	motif 3; other site
862967004535	SNARE associated Golgi protein; Region: SNARE_assoc; cl00429
862967004536	Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586
862967004537	acetyl-CoA carboxylase subunit alpha; Provisional; Region: PRK12319
862967004538	acetyl-CoA carboxylase subunit beta; Validated; Region: PRK05654
862967004539	Uncharacterized protein family UPF0547; Region: UPF0547; pfam10571
862967004540	malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682
862967004541	acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591
862967004542	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
862967004543	Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786
862967004544	Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878
862967004545	FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288
862967004546	acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated; Region: PRK06302
862967004547	The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850
862967004548	carboxyltransferase (CT) interaction site; other site
862967004549	biotinylation site [posttranslational modification]; other site
862967004550	3-oxoacyl-(acyl carrier protein) synthase II; Reviewed; Region: PRK07314
862967004551	Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834
862967004552	dimer interface [polypeptide binding]; other site
862967004553	active site
862967004554	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557
862967004555	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
862967004556	NAD(P) binding site [chemical binding]; other site
862967004557	active site
862967004558	(acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331
862967004559	malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128
862967004560	putative enoyl-[acyl-carrier-protein] reductase II; Region: enACPred_II; TIGR03151
862967004561	2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730
862967004562	FMN binding site [chemical binding]; other site
862967004563	substrate binding site [chemical binding]; other site
862967004564	putative catalytic residue [active]
862967004565	acyl carrier protein; Provisional; Region: acpP; PRK00982
862967004566	3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352
862967004567	Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830
862967004568	dimer interface [polypeptide binding]; other site
862967004569	active site
862967004570	CoA binding pocket [chemical binding]; other site
862967004571	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
862967004572	MarR family; Region: MarR_2; pfam12802
862967004573	enoyl-CoA hydratase; Provisional; Region: PRK07260
862967004574	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
862967004575	substrate binding site [chemical binding]; other site
862967004576	oxyanion hole (OAH) forming residues; other site
862967004577	trimer interface [polypeptide binding]; other site
862967004578	aspartate kinase; Reviewed; Region: PRK09034
862967004579	AAK_AKiii-YclM-BS: Amino Acid Kinase Superfamily (AAK), AKiii-YclM-BS; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the lysine plus threonine-sensitive aspartokinase isoenzyme AKIII, a monofunctional class enzyme found in...; Region: AAK_AKiii-YclM-BS; cd04245
862967004580	putative catalytic residues [active]
862967004581	putative nucleotide binding site [chemical binding]; other site
862967004582	putative aspartate binding site [chemical binding]; other site
862967004583	ACT domains located C-terminal to the catalytic domain of the lysine plus threonine-sensitive aspartokinase isoenzyme AKIII; Region: ACT_AKiii-YclM-BS_1; cd04911
862967004584	allosteric regulatory residue; other site
862967004585	ACT domains located C-terminal to the catalytic domain of the lysine plus threonine-sensitive aspartokinase isoenzyme AKIII; Region: ACT_AKiii-YclM-BS_2; cd04916
862967004586	ABC-type metal ion transport system, permease component [Inorganic ion transport and metabolism]; Region: AbcD; COG2011
862967004587	ABC-type metal ion transport system, ATPase component [Inorganic ion transport and metabolism]; Region: AbcC; COG1135
862967004588	ATP-binding cassette domain of methionine transporter; Region: ABC_MetN_methionine_transporter; cd03258
862967004589	Walker A/P-loop; other site
862967004590	ATP binding site [chemical binding]; other site
862967004591	Q-loop/lid; other site
862967004592	ABC transporter signature motif; other site
862967004593	Walker B; other site
862967004594	D-loop; other site
862967004595	H-loop/switch region; other site
862967004596	NIL domain; Region: NIL; pfam09383
862967004597	hypothetical protein; Provisional; Region: PRK06446
862967004598	Uncharacterized M20 Dipeptidases; Region: M20_dipept_like_4; cd05681
862967004599	metal binding site [ion binding]; metal-binding site
862967004600	dimer interface [polypeptide binding]; other site
862967004601	ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464
862967004602	NLPA lipoprotein; Region: Lipoprotein_9; pfam03180
862967004603	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
862967004604	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
862967004605	substrate binding pocket [chemical binding]; other site
862967004606	membrane-bound complex binding site; other site
862967004607	hinge residues; other site
862967004608	Domain of unknown function (DUF4352); Region: DUF4352; pfam11611
862967004609	hypothetical protein; Provisional; Region: PRK12378
862967004610	hypothetical protein; Provisional; Region: PRK13670
862967004611	HIGH Nucleotidyl Transferase; Region: HIGH_NTase1; cl17673
862967004612	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
862967004613	S-adenosylmethionine binding site [chemical binding]; other site
862967004614	Uncharacterized homolog of plant Iojap protein [Function unknown]; Region: COG0799
862967004615	Isochorismatase family; Region: Isochorismatase; pfam00857
862967004616	Nicotinamidase_ related amidohydrolases.  Cysteine hydrolases of unknown function that share the catalytic triad with other amidohydrolases, like nicotinamidase, which converts nicotinamide to nicotinic acid and ammonia; Region: nicotinamidase_related; cd01014
862967004617	catalytic triad [active]
862967004618	conserved cis-peptide bond; other site
862967004619	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
862967004620	Zn2+ binding site [ion binding]; other site
862967004621	Mg2+ binding site [ion binding]; other site
862967004622	nicotinic acid mononucleotide adenylyltransferase; Provisional; Region: nadD; PRK00071
862967004623	Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165
862967004624	active site
862967004625	(T/H)XGH motif; other site
862967004626	Predicted RNA-binding protein containing KH domain, possibly ribosomal protein [Translation, ribosomal structure and biogenesis]; Region: COG1534
862967004627	GTPase YqeH; Provisional; Region: PRK13796
862967004628	Circularly permuted YqeH GTPase; Region: YqeH; cd01855
862967004629	GTP/Mg2+ binding site [chemical binding]; other site
862967004630	G4 box; other site
862967004631	G5 box; other site
862967004632	G1 box; other site
862967004633	Switch I region; other site
862967004634	G2 box; other site
862967004635	G3 box; other site
862967004636	Switch II region; other site
862967004637	Predicted hydrolase of the HAD superfamily [General function prediction only]; Region: COG2179
862967004638	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
862967004639	active site
862967004640	motif I; other site
862967004641	motif II; other site
862967004642	Uncharacterized conserved protein [Function unknown]; Region: COG0398
862967004643	SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335
862967004644	Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950
862967004645	EamA-like transporter family; Region: EamA; pfam00892
862967004646	Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063
862967004647	(2R,3R)-2,3-butanediol dehydrogenase; Region: butanediol_DH_like; cd08233
862967004648	putative NAD(P) binding site [chemical binding]; other site
862967004649	catalytic Zn binding site [ion binding]; other site
862967004650	aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477
862967004651	GatB/GatE catalytic domain; Region: GatB_N; pfam02934
862967004652	GatB domain; Region: GatB_Yqey; pfam02637
862967004653	Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154
862967004654	aspartyl/glutamyl-tRNA amidotransferase subunit A; Reviewed; Region: gatA; PRK00012
862967004655	aspartyl/glutamyl-tRNA amidotransferase subunit C; Reviewed; Region: gatC; PRK00034
862967004656	aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476
862967004657	EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317
862967004658	dimer interface [polypeptide binding]; other site
862967004659	anticodon binding site; other site
862967004660	Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777
862967004661	homodimer interface [polypeptide binding]; other site
862967004662	motif 1; other site
862967004663	active site
862967004664	motif 2; other site
862967004665	GAD domain; Region: GAD; pfam02938
862967004666	Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA.   PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268
862967004667	active site
862967004668	motif 3; other site
862967004669	Isochorismatase family; Region: Isochorismatase; pfam00857
862967004670	Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431
862967004671	catalytic triad [active]
862967004672	conserved cis-peptide bond; other site
862967004673	Pleiotropic transcriptional repressor [Transcription]; Region: CodY; COG4465
862967004674	CodY GAF-like domain; Region: CodY; pfam06018
862967004675	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
862967004676	dimerization interface [polypeptide binding]; other site
862967004677	putative Zn2+ binding site [ion binding]; other site
862967004678	putative DNA binding site [nucleotide binding]; other site
862967004679	aminotransferase AlaT; Validated; Region: PRK09265
862967004680	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
862967004681	pyridoxal 5'-phosphate binding site [chemical binding]; other site
862967004682	homodimer interface [polypeptide binding]; other site
862967004683	catalytic residue [active]
862967004684	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
862967004685	Ligand Binding Site [chemical binding]; other site
862967004686	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
862967004687	haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282
862967004688	active site
862967004689	motif I; other site
862967004690	motif II; other site
862967004691	haloacid dehalogenase-like hydrolase; Region: HAD; cl17202
862967004692	Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in Exiguobacterium sibiricum YP_001813558.1 protein and its bacterial homologs; Region: NTP-PPase_YP_001813558; cd11545
862967004693	putative nucleotide binding site [chemical binding]; other site
862967004694	putative metal binding site [ion binding]; other site
862967004695	Type II (periplasmic) bacterial L-asparaginase; Region: L-asparaginase_II; cd08964
862967004696	active site
862967004697	homotetramer interface [polypeptide binding]; other site
862967004698	homodimer interface [polypeptide binding]; other site
862967004699	ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917
862967004700	Y-family of DNA polymerases; Region: PolY; cl12025
862967004701	RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488
862967004702	generic binding surface II; other site
862967004703	ssDNA binding site; other site
862967004704	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
862967004705	ATP binding site [chemical binding]; other site
862967004706	putative Mg++ binding site [ion binding]; other site
862967004707	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
862967004708	nucleotide binding region [chemical binding]; other site
862967004709	ATP-binding site [chemical binding]; other site
862967004710	alanine racemase; Reviewed; Region: alr; PRK00053
862967004711	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430
862967004712	active site
862967004713	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
862967004714	dimer interface [polypeptide binding]; other site
862967004715	substrate binding site [chemical binding]; other site
862967004716	catalytic residues [active]
862967004717	4'-phosphopantetheinyl transferase; Provisional; Region: acpS; PRK00070
862967004718	3-deoxy-D-arabino-heptulosonate 7-phosphate (DAHP) synthase [Amino acid transport and metabolism]; Region: AroG; cl17260
862967004719	DAHP synthetase I family; Region: DAHP_synth_1; pfam00793
862967004720	preprotein translocase subunit SecA; Reviewed; Region: PRK12904
862967004721	SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958
862967004722	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
862967004723	nucleotide binding region [chemical binding]; other site
862967004724	ATP-binding site [chemical binding]; other site
862967004725	SEC-C motif; Region: SEC-C; pfam02810
862967004726	Amino acid permease; Region: AA_permease_2; pfam13520
862967004727	Tripartite ATP-independent periplasmic transporters, DctQ component; Region: DctQ; cl01181
862967004728	LXG domain of WXG superfamily; Region: LXG; pfam04740
862967004729	type VII secretion effector, SACOL2603 family; Region: T7SS_SACOL2603; TIGR04197
862967004730	Phosphomannose isomerase [Carbohydrate transport and metabolism]; Region: ManA; COG1482
862967004731	mannose-6-phosphate isomerase, class I; Region: manA; TIGR00218
862967004732	Transcriptional regulators [Transcription]; Region: PhnF; COG2188
862967004733	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
862967004734	DNA-binding site [nucleotide binding]; DNA binding site
862967004735	The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; Region: UTRA; smart00866
862967004736	Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455
862967004737	cellobiose phosphotransferase system IIC component; Reviewed; Region: celD; PRK09592
862967004738	Beta-glucosidase/6-phospho-beta-glucosidase/beta- galactosidase [Carbohydrate transport and metabolism]; Region: BglB; COG2723
862967004739	beta-galactosidase; Region: BGL; TIGR03356
862967004740	Cupin domain; Region: Cupin_2; pfam07883
862967004741	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
862967004742	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
862967004743	ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254
862967004744	Walker A/P-loop; other site
862967004745	ATP binding site [chemical binding]; other site
862967004746	Q-loop/lid; other site
862967004747	ABC transporter signature motif; other site
862967004748	Walker B; other site
862967004749	D-loop; other site
862967004750	H-loop/switch region; other site
862967004751	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
862967004752	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
862967004753	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
862967004754	Walker A/P-loop; other site
862967004755	ATP binding site [chemical binding]; other site
862967004756	Q-loop/lid; other site
862967004757	ABC transporter signature motif; other site
862967004758	Walker B; other site
862967004759	D-loop; other site
862967004760	H-loop/switch region; other site
862967004761	Transcriptional regulators [Transcription]; Region: MarR; COG1846
862967004762	MarR family; Region: MarR_2; pfam12802
862967004763	NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902
862967004764	Old yellow enzyme (OYE)-related FMN binding domain, group 4.  Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a reducing agent with oxygens, quinones, and alpha,beta-unsaturated aldehydes and ketones, and can act as...; Region: OYE_like_4_FMN; cd04735
862967004765	putative active site [active]
862967004766	putative FMN binding site [chemical binding]; other site
862967004767	putative substrate binding site [chemical binding]; other site
862967004768	putative catalytic residue [active]
862967004769	Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487
862967004770	active site
862967004771	catalytic residues [active]
862967004772	metal binding site [ion binding]; metal-binding site
862967004773	Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940
862967004774	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012
862967004775	nucleotide binding site [chemical binding]; other site
862967004776	PTS system, sucrose-specific IIBC component; Region: PTS-II-BC-sucr; TIGR01996
862967004777	PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212
862967004778	active site turn [active]
862967004779	phosphorylation site [posttranslational modification]
862967004780	Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263
862967004781	PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_glc; cd00210
862967004782	HPr interaction site; other site
862967004783	glycerol kinase (GK) interaction site [polypeptide binding]; other site
862967004784	active site
862967004785	phosphorylation site [posttranslational modification]
862967004786	sucrose-6-phosphate hydrolase; Region: scrB_fam; TIGR01322
862967004787	Glycosyl hydrolase family 32, beta-fructosidases; Region: GH32_B_Fructosidase; cd08996
862967004788	substrate binding [chemical binding]; other site
862967004789	active site
862967004790	Glycosyl hydrolases family 32 C terminal; Region: Glyco_hydro_32C; pfam08244
862967004791	Transcriptional regulators [Transcription]; Region: PurR; COG1609
862967004792	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
862967004793	DNA binding site [nucleotide binding]
862967004794	domain linker motif; other site
862967004795	Ligand binding domain of the lacI-like transcription regulator from a novel metal-reducing bacterium Alkaliphilus Metalliredigens (strain Qymf) and its close homologs; Region: PBP1_Qymf_like; cd06291
862967004796	dimerization interface [polypeptide binding]; other site
862967004797	ligand binding site [chemical binding]; other site
862967004798	sodium binding site [ion binding]; other site
862967004799	Predicted hydrolases of the HAD superfamily [General function prediction only]; Region: Cof; COG0561
862967004800	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
862967004801	active site
862967004802	motif I; other site
862967004803	motif II; other site
862967004804	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cl17915
862967004805	ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124
862967004806	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
862967004807	Walker A/P-loop; other site
862967004808	ATP binding site [chemical binding]; other site
862967004809	Q-loop/lid; other site
862967004810	ABC transporter signature motif; other site
862967004811	Walker B; other site
862967004812	D-loop; other site
862967004813	H-loop/switch region; other site
862967004814	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352
862967004815	ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444
862967004816	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
862967004817	Walker A/P-loop; other site
862967004818	ATP binding site [chemical binding]; other site
862967004819	Q-loop/lid; other site
862967004820	ABC transporter signature motif; other site
862967004821	Walker B; other site
862967004822	D-loop; other site
862967004823	H-loop/switch region; other site
862967004824	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
862967004825	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173
862967004826	N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911
862967004827	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
862967004828	dimer interface [polypeptide binding]; other site
862967004829	conserved gate region; other site
862967004830	putative PBP binding loops; other site
862967004831	ABC-ATPase subunit interface; other site
862967004832	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
862967004833	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601
862967004834	dimer interface [polypeptide binding]; other site
862967004835	conserved gate region; other site
862967004836	putative PBP binding loops; other site
862967004837	ABC-ATPase subunit interface; other site
862967004838	ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166
862967004839	The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504
862967004840	peptide binding site [polypeptide binding]; other site
862967004841	The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504
862967004842	peptide binding site [polypeptide binding]; other site
862967004843	Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496
862967004844	Solo B3/4 domain (OB-fold DNA/RNA-binding) of Phe-aaRS-beta [General function prediction only]; Region: COG3382
862967004845	B3/4 domain; Region: B3_4; pfam03483
862967004846	CTP synthetase; Validated; Region: pyrG; PRK05380
862967004847	CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113
862967004848	Catalytic site [active]
862967004849	active site
862967004850	UTP binding site [chemical binding]; other site
862967004851	Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746
862967004852	active site
862967004853	putative oxyanion hole; other site
862967004854	catalytic triad [active]
862967004855	DNA-directed RNA polymerase delta subunit; Region: RNA_pol_delta; pfam05066
862967004856	trigger factor; Provisional; Region: tig; PRK01490
862967004857	FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254
862967004858	Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698
862967004859	hypothetical protein; Provisional; Region: PRK13690
862967004860	Predicted membrane protein [Function unknown]; Region: COG4720
862967004861	Protein of unknown function (DUF3816); Region: DUF3816; pfam12822
862967004862	4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169
862967004863	dimer interface [polypeptide binding]; other site
862967004864	substrate binding site [chemical binding]; other site
862967004865	ATP binding site [chemical binding]; other site
862967004866	tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021
862967004867	Eukaryotic and bacterial pseudouridine synthases similar to E.  coli TruA; Region: PseudoU_synth_EcTruA; cd02570
862967004868	dimerization interface 3.5A [polypeptide binding]; other site
862967004869	active site
862967004870	Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447
862967004871	nudix motif; other site
862967004872	chaperone protein DnaJ; Provisional; Region: PRK14276
862967004873	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257
862967004874	HSP70 interaction site [polypeptide binding]; other site
862967004875	C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cl03262
862967004876	substrate binding site [polypeptide binding]; other site
862967004877	Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719
862967004878	Zn binding sites [ion binding]; other site
862967004879	C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747
862967004880	dimer interface [polypeptide binding]; other site
862967004881	molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290
862967004882	Nucleotide-binding domain of human HSPA9 and similar proteins; Region: HSPA9-Ssq1-like_NBD; cd10234
862967004883	nucleotide binding site [chemical binding]; other site
862967004884	NEF interaction site [polypeptide binding]; other site
862967004885	SBD interface [polypeptide binding]; other site
862967004886	GrpE; Region: GrpE; pfam01025
862967004887	GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446
862967004888	dimer interface [polypeptide binding]; other site
862967004889	hsp70 (ATPase domain) interactions [polypeptide binding]; other site
862967004890	heat-inducible transcription repressor; Provisional; Region: hrcA; PRK00082
862967004891	Winged helix-turn-helix transcription repressor, HrcA DNA-binding; Region: HrcA_DNA-bdg; pfam03444
862967004892	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
862967004893	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
862967004894	Walker A/P-loop; other site
862967004895	ATP binding site [chemical binding]; other site
862967004896	Q-loop/lid; other site
862967004897	ABC transporter signature motif; other site
862967004898	Walker B; other site
862967004899	D-loop; other site
862967004900	H-loop/switch region; other site
862967004901	Protein of unknown function (DUF2812); Region: DUF2812; pfam11193
862967004902	Predicted transcriptional regulators [Transcription]; Region: COG1695
862967004903	Transcriptional regulator PadR-like family; Region: PadR; cl17335
862967004904	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
862967004905	catalytic core [active]
862967004906	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
862967004907	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
862967004908	Uncharacterized proteins with similarity to Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL_like_DUF711; cd08025
862967004909	ACT domain proteins similar to the yet uncharacterized Streptococcus pneumoniae ACT domain protein; Region: ACT_1ZPV; cd04872
862967004910	Transcriptional regulators [Transcription]; Region: PurR; COG1609
862967004911	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
862967004912	DNA binding site [nucleotide binding]
862967004913	domain linker motif; other site
862967004914	Ligand-binding domain of DNA transcription repressor RegR and other putative regulators such as KdgR and EndR; Region: PBP1_RegR_EndR_KdgR_like; cd06283
862967004915	putative dimerization interface [polypeptide binding]; other site
862967004916	putative ligand binding site [chemical binding]; other site
862967004917	Heparinase II/III-like protein; Region: Hepar_II_III; pfam07940
862967004918	Preprotein translocase subunit YajC [Intracellular trafficking and secretion]; Region: YajC; COG1862
862967004919	Phosphotransferase system, mannose/fructose/N-acetylgalactosamine-specific component IID [Carbohydrate transport and metabolism]; Region: ManZ; COG3716
862967004920	Phosphotransferase system, mannose/fructose/N-acetylgalactosamine-specific component IIC [Carbohydrate transport and metabolism]; Region: ManY; COG3715
862967004921	PTS_IIB, PTS system, Mannose/sorbose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_man; cd00001
862967004922	active site
862967004923	phosphorylation site [posttranslational modification]
862967004924	Glycosyl Hydrolase Family 88; Region: Glyco_hydro_88; pfam07470
862967004925	PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006
862967004926	active pocket/dimerization site; other site
862967004927	active site
862967004928	phosphorylation site [posttranslational modification]
862967004929	gluconate 5-dehydrogenase; Provisional; Region: PRK07097
862967004930	gluconate 5-dehydrogenase (Ga5DH)-like, classical (c) SDRs; Region: Ga5DH-like_SDR_c; cd05347
862967004931	NADP binding site [chemical binding]; other site
862967004932	homodimer interface [polypeptide binding]; other site
862967004933	active site
862967004934	hypothetical protein; Provisional; Region: PRK09273
862967004935	Ribose 5-phosphate isomerase RpiB [Carbohydrate transport and metabolism]; Region: RpiB; COG0698
862967004936	Ribose-5-phosphate isomerase; Region: DUF3666; pfam12408
862967004937	2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166
862967004938	Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524
862967004939	substrate binding site [chemical binding]; other site
862967004940	ATP binding site [chemical binding]; other site
862967004941	2-keto-3-deoxy-6-phosphogluconate aldolase [Carbohydrate transport and metabolism]; Region: Eda; COG0800
862967004942	KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452
862967004943	active site
862967004944	intersubunit interface [polypeptide binding]; other site
862967004945	catalytic residue [active]
862967004946	Cna protein B-type domain; Region: Cna_B; pfam05738
862967004947	Cna protein B-type domain; Region: Cna_B; pfam05738
862967004948	Repeat unit of collagen-binding protein domain B; Region: CollagenBindB; cd00222
862967004949	domain interaction interfaces [polypeptide binding]; other site
862967004950	Carbohydrate binding domain; Region: CBM_4_9; pfam02018
862967004951	Glycosaminoglycan (GAG) polysaccharide lyase family. This family consists of a group of secreted bacterial lyase enzymes capable of acting on glycosaminoglycans, such as hyaluronan and chondroitin, in the extracellular matrix of host tissues; Region: GAG_Lyase; cd01083
862967004952	substrate binding site [chemical binding]; other site
862967004953	catalytic residues [active]
862967004954	Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per...; Region: GSH_Peroxidase; cd00340
862967004955	catalytic residues [active]
862967004956	dimer interface [polypeptide binding]; other site
862967004957	Cna protein B-type domain; Region: Cna_B; pfam05738
862967004958	Phage derived protein Gp49-like (DUF891); Region: Gp49; pfam05973
862967004959	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
862967004960	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
862967004961	Walker A/P-loop; other site
862967004962	ATP binding site [chemical binding]; other site
862967004963	Q-loop/lid; other site
862967004964	ABC transporter signature motif; other site
862967004965	Walker B; other site
862967004966	D-loop; other site
862967004967	H-loop/switch region; other site
862967004968	ABC-type bacteriocin/lantibiotic exporters, contain an N-terminal double-glycine peptidase domain [Defense mechanisms]; Region: SunT; COG2274
862967004969	Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various bacteriocins (mostly non-lantibiotic); Region: Peptidase_C39_like; cl00296
862967004970	putative active site [active]
862967004971	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
862967004972	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
862967004973	Walker A/P-loop; other site
862967004974	ATP binding site [chemical binding]; other site
862967004975	Q-loop/lid; other site
862967004976	ABC transporter signature motif; other site
862967004977	Walker B; other site
862967004978	D-loop; other site
862967004979	H-loop/switch region; other site
862967004980	Domain of unknown function (DUF4411); Region: DUF4411; pfam14367
862967004981	Domain of unknown function (DUF955); Region: DUF955; cl01076
862967004982	heavy metal translocating P-type ATPase; Region: ATPase-IB_hvy; TIGR01525
862967004983	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
862967004984	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
862967004985	motif II; other site
862967004986	MULE transposase domain; Region: MULE; pfam10551
862967004987	Fic/DOC family; Region: Fic; cl00960
862967004988	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
862967004989	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
862967004990	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
862967004991	Walker A/P-loop; other site
862967004992	ATP binding site [chemical binding]; other site
862967004993	Q-loop/lid; other site
862967004994	ABC transporter signature motif; other site
862967004995	Walker B; other site
862967004996	D-loop; other site
862967004997	H-loop/switch region; other site
862967004998	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
862967004999	FeS/SAM binding site; other site
862967005000	Replication initiation factor; Region: Rep_trans; pfam02486
862967005001	Helix-turn-helix domain; Region: HTH_17; pfam12728
862967005002	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
862967005003	active site
862967005004	DNA binding site [nucleotide binding]
862967005005	Int/Topo IB signature motif; other site
862967005006	30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132
862967005007	Ribosomal protein L13.  Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392
862967005008	23S rRNA interface [nucleotide binding]; other site
862967005009	L3 interface [polypeptide binding]; other site
862967005010	EDD domain protein, DegV family; Region: DegV; TIGR00762
862967005011	Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645
862967005012	rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566
862967005013	RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032
862967005014	SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588
862967005015	glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650
862967005016	The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301
862967005017	Walker A/P-loop; other site
862967005018	ATP binding site [chemical binding]; other site
862967005019	Q-loop/lid; other site
862967005020	ABC transporter signature motif; other site
862967005021	Walker B; other site
862967005022	D-loop; other site
862967005023	H-loop/switch region; other site
862967005024	TOBE domain; Region: TOBE_2; pfam08402
862967005025	Regulator of polyketide synthase expression [Signal transduction mechanisms / Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2508
862967005026	PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556
862967005027	cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260
862967005028	catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672
862967005029	active site
862967005030	HIGH motif; other site
862967005031	catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672
862967005032	KMSKS motif; other site
862967005033	Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020
862967005034	tRNA binding surface [nucleotide binding]; other site
862967005035	anticodon binding site; other site
862967005036	Phosphorylase superfamily; Region: PNP_UDP_1; pfam01048
862967005037	Serine acetyltransferase [Amino acid transport and metabolism]; Region: CysE; COG1045
862967005038	Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354
862967005039	trimer interface [polypeptide binding]; other site
862967005040	active site
862967005041	substrate binding site [chemical binding]; other site
862967005042	CoA binding site [chemical binding]; other site
862967005043	polynucleotide phosphorylase/polyadenylase; Provisional; Region: PRK11824
862967005044	Polyribonucleotide nucleotidyltransferase, repeat 1; Region: RNase_PH_PNPase_1; cd11363
862967005045	RNase E interface [polypeptide binding]; other site
862967005046	trimer interface [polypeptide binding]; other site
862967005047	Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726
862967005048	Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364
862967005049	RNase E interface [polypeptide binding]; other site
862967005050	trimer interface [polypeptide binding]; other site
862967005051	active site
862967005052	Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393
862967005053	S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927
862967005054	RNA binding site [nucleotide binding]; other site
862967005055	oligoendopeptidase F; Region: pepF; TIGR00181
862967005056	Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins); Region: GluZincin; cl14813
862967005057	Zn binding site [ion binding]; other site
862967005058	Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353
862967005059	16S/18S rRNA binding site [nucleotide binding]; other site
862967005060	S13e-L30e interaction site [polypeptide binding]; other site
862967005061	25S rRNA binding site [nucleotide binding]; other site
862967005062	16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187
862967005063	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
862967005064	RNA binding surface [nucleotide binding]; other site
862967005065	Pseudouridine synthase, Escherichia coli RsuA like; Region: PseudoU_synth_RsuA; cd02553
862967005066	active site
862967005067	uracil binding [chemical binding]; other site
862967005068	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
862967005069	Major Facilitator Superfamily; Region: MFS_1; pfam07690
862967005070	putative substrate translocation pore; other site
862967005071	Polyphosphate(polyP) polymerase domain of yeast vacuolar transport chaperone (VTC) proteins VTC-2, -3 and- 4, and similar proteins; Region: PolyPPase_VTC_like; cd07750
862967005072	putative metal binding residues [ion binding]; other site
862967005073	signature motif; other site
862967005074	dimer interface [polypeptide binding]; other site
862967005075	active site
862967005076	polyP binding site; other site
862967005077	substrate binding site [chemical binding]; other site
862967005078	acceptor-phosphate pocket; other site
862967005079	CotH protein; Region: CotH; pfam08757
862967005080	Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063
862967005081	Interdomain contacts; other site
862967005082	Cytokine receptor motif; other site
862967005083	Predicted membrane protein [Function unknown]; Region: COG4267
862967005084	This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_3; cd03813
862967005085	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
862967005086	Uncharacterized protein conserved in bacteria (DUF2194); Region: DUF2194; pfam09960
862967005087	Putative NodB-like catalytic domain of uncharacterized proteins found in bacteria; Region: CE4_COG4878; cd10924
862967005088	NodB motif; other site
862967005089	putative active site [active]
862967005090	putative catalytic site [active]
862967005091	putative Zn binding site [ion binding]; other site
862967005092	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
862967005093	NAD(P) binding site [chemical binding]; other site
862967005094	active site
862967005095	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
862967005096	Domain of unknown function (DUF4118); Region: DUF4118; pfam13493
862967005097	Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487
862967005098	active site
862967005099	catalytic residues [active]
862967005100	metal binding site [ion binding]; metal-binding site
862967005101	Predicted membrane protein [Function unknown]; Region: COG2261
862967005102	Thermophilic metalloprotease (M29); Region: Peptidase_M29; pfam02073
862967005103	Leucyl aminopeptidase (aminopeptidase T) [Amino acid transport and metabolism]; Region: AmpS; COG2309
862967005104	DNA polymerase III PolC; Validated; Region: polC; PRK00448
862967005105	DNA polymerase III polC-type N-terminus; Region: DNA_pol3_alph_N; pfam11490
862967005106	polC_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold nucleic acid binding domain of Bacillus subtilis type C replicative DNA polymerase III alpha subunit (polC). Replication in B. subtilis and Staphylococcus aureus requires two...; Region: polC_OBF; cd04484
862967005107	generic binding surface II; other site
862967005108	generic binding surface I; other site
862967005109	Polymerase and Histidinol Phosphatase domain; Region: PHP; cl17102
862967005110	active site
862967005111	DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127
862967005112	active site
862967005113	catalytic site [active]
862967005114	substrate binding site [chemical binding]; other site
862967005115	Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III at PolC gene; Region: PHP_PolIIIA_POLC; cd07435
862967005116	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
862967005117	active site
862967005118	motif I; other site
862967005119	motif II; other site
862967005120	Gram-positive signal peptide, YSIRK family; Region: YSIRK_signal; TIGR01168
862967005121	pullulanase, extracellular, Gram-positive; Region: pullulan_Gpos; TIGR02102
862967005122	Family 41 Carbohydrate-Binding Module from pullulanase-like enzymes; Region: CBM41_pullulanase; cd10315
862967005123	carbohydrate binding site [chemical binding]; other site
862967005124	Family 41 Carbohydrate-Binding Module from pullulanase-like enzymes; Region: CBM41_pullulanase; cd10315
862967005125	carbohydrate binding site [chemical binding]; other site
862967005126	Early set domain associated with the catalytic domain of pullulanase (also called dextrinase and alpha-dextrin endo-1,6-alpha glucosidase); Region: E_set_Pullulanase; cd02860
862967005127	Alpha amylase catalytic domain found in Pullulanase (also called dextrinase; alpha-dextrin endo-1,6-alpha glucosidase), limit dextrinase, and related proteins; Region: AmyAc_Pullulanase_LD-like; cd11341
862967005128	Ca binding site [ion binding]; other site
862967005129	active site
862967005130	catalytic site [active]
862967005131	leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390
862967005132	catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812
862967005133	HIGH motif; other site
862967005134	Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603
862967005135	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
862967005136	active site
862967005137	KMSKS motif; other site
862967005138	Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958
862967005139	tRNA binding surface [nucleotide binding]; other site
862967005140	Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020
862967005141	Predicted metalloendopeptidase [Posttranslational modification, protein turnover, chaperones]; Region: PepO; COG3590
862967005142	Peptidase family M13 includes neprilysin, endothelin-converting enzyme I; Region: M13; cd08662
862967005143	active site
862967005144	Zn binding site [ion binding]; other site
862967005145	ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121
862967005146	ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235
862967005147	ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108
862967005148	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
862967005149	ABC-ATPase subunit  interface; other site
862967005150	dimer interface [polypeptide binding]; other site
862967005151	putative PBP binding regions; other site
862967005152	ABC-type metal ion transport system, periplasmic component/surface adhesin [Inorganic ion transport and metabolism]; Region: LraI; COG0803
862967005153	Metal binding protein PsaA.  These proteins have been shown to function as initial receptors in ABC transport of Mn2+ and as surface adhesins in some eubacterial species.  They belong to the TroA superfamily of periplasmic metal binding proteins that...; Region: PsaA; cd01137
862967005154	metal binding site [ion binding]; metal-binding site
862967005155	Mn-dependent transcriptional regulator [Transcription]; Region: TroR; COG1321
862967005156	Iron dependent repressor, N-terminal DNA binding domain; Region: Fe_dep_repress; pfam01325
862967005157	Iron dependent repressor, metal binding and dimerisation domain; Region: Fe_dep_repr_C; pfam02742
862967005158	FeoA domain; Region: FeoA; pfam04023
862967005159	D-Tyrosyl-tRNAtyr deacylases; a class of tRNA-dependent hydrolases which are capable of hydrolyzing the ester bond of D-Tyrosyl-tRNA reducing the level of cellular D-Tyrosine while recycling the peptidyl-tRNA; found in bacteria and in eukaryotes but not...; Region: Dtyr_deacylase; cd00563
862967005160	putative active site [active]
862967005161	dimerization interface [polypeptide binding]; other site
862967005162	putative tRNAtyr binding site [nucleotide binding]; other site
862967005163	Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317
862967005164	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
862967005165	Zn2+ binding site [ion binding]; other site
862967005166	Mg2+ binding site [ion binding]; other site
862967005167	Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399
862967005168	synthetase active site [active]
862967005169	NTP binding site [chemical binding]; other site
862967005170	metal binding site [ion binding]; metal-binding site
862967005171	TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668
862967005172	ACT  domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876
862967005173	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1385
862967005174	RNA methyltransferase, RsmE family; Region: TIGR00046
862967005175	Ribosomal protein L11 methyltransferase (PrmA); Region: PrmA; pfam06325
862967005176	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
862967005177	S-adenosylmethionine binding site [chemical binding]; other site
862967005178	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
862967005179	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
862967005180	Coenzyme A binding pocket [chemical binding]; other site
862967005181	Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_23; cd04682
862967005182	nudix motif; other site
862967005183	Protein of unknown function (DUF3013); Region: DUF3013; pfam11217
862967005184	recombination factor protein RarA; Reviewed; Region: PRK13342
862967005185	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
862967005186	Walker A motif; other site
862967005187	ATP binding site [chemical binding]; other site
862967005188	Walker B motif; other site
862967005189	arginine finger; other site
862967005190	MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002
862967005191	haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282
862967005192	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
862967005193	active site
862967005194	motif I; other site
862967005195	motif II; other site
862967005196	haloacid dehalogenase-like hydrolase; Region: HAD; cl17202
862967005197	Transcriptional regulators [Transcription]; Region: PurR; COG1609
862967005198	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
862967005199	DNA binding site [nucleotide binding]
862967005200	domain linker motif; other site
862967005201	Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011
862967005202	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1636
862967005203	chaperonin GroEL; Reviewed; Region: groEL; PRK12849
862967005204	GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344
862967005205	ring oligomerisation interface [polypeptide binding]; other site
862967005206	ATP/Mg binding site [chemical binding]; other site
862967005207	stacking interactions; other site
862967005208	hinge regions; other site
862967005209	Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320
862967005210	oligomerisation interface [polypeptide binding]; other site
862967005211	mobile loop; other site
862967005212	roof hairpin; other site
862967005213	Archaeal/vacuolar-type H+-ATPase subunit I [Energy production and conversion]; Region: NtpI; COG1269
862967005214	PTS system mannose/fructose/sorbose family IID component; Region: EIID-AGA; pfam03613
862967005215	PTS system sorbose-specific iic component; Region: EII-Sor; pfam03609
862967005216	PTS system sorbose subfamily IIB component; Region: PTSIIB_sorb; pfam03830
862967005217	active site
862967005218	phosphorylation site [posttranslational modification]
862967005219	PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cl00025
862967005220	active site
862967005221	active pocket/dimerization site; other site
862967005222	phosphorylation site [posttranslational modification]
862967005223	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
862967005224	Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416
862967005225	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
862967005226	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
862967005227	active site
862967005228	phosphorylation site [posttranslational modification]
862967005229	intermolecular recognition site; other site
862967005230	dimerization interface [polypeptide binding]; other site
862967005231	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
862967005232	DNA binding residues [nucleotide binding]
862967005233	dimerization interface [polypeptide binding]; other site
862967005234	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585
862967005235	Histidine kinase; Region: HisKA_3; pfam07730
862967005236	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
862967005237	ATP binding site [chemical binding]; other site
862967005238	Mg2+ binding site [ion binding]; other site
862967005239	G-X-G motif; other site
862967005240	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: RbsB; COG1879
862967005241	Periplasmic sugar-binding domain of active transport systems that are members of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_sugar_binding_like; cd01536
862967005242	ligand binding site [chemical binding]; other site
862967005243	Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629
862967005244	SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496
862967005245	dimer interface [polypeptide binding]; other site
862967005246	ssDNA binding site [nucleotide binding]; other site
862967005247	tetramer (dimer of dimers) interface [polypeptide binding]; other site
862967005248	tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain.  PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796
862967005249	putative tRNA-binding site [nucleotide binding]; other site
862967005250	TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947
862967005251	catalytic residues [active]
862967005252	Cellulase M and related proteins [Carbohydrate transport and metabolism]; Region: FrvX; COG1363
862967005253	M42 Peptidases, also known as glutamyl aminopeptidase family; Region: M42; cd05638
862967005254	oligomer interface [polypeptide binding]; other site
862967005255	active site
862967005256	metal binding site [ion binding]; metal-binding site
862967005257	ECF-type riboflavin transporter, S component; Region: ECF-ribofla_trS; cl17272
862967005258	Protein of unknown function (DUF3816); Region: DUF3816; pfam12822
862967005259	Folylpolyglutamate synthase [Coenzyme metabolism]; Region: FolC; COG0285
862967005260	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
862967005261	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
862967005262	prolyl-tRNA synthetase; Provisional; Region: PRK09194
862967005263	Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA.   PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268
862967005264	motif 1; other site
862967005265	dimer interface [polypeptide binding]; other site
862967005266	active site
862967005267	motif 2; other site
862967005268	INS is an amino acid-editing domain inserted (INS) into the bacterial class II prolyl-tRNA synthetase (ProRS) however, this CD is not exclusively bacterial. It is also found at the N-terminus of the eukaryotic/archaea-like ProRS's of yeasts and...; Region: ProRS-INS; cd04334
862967005269	putative deacylase active site [active]
862967005270	Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA.   PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268
862967005271	active site
862967005272	motif 3; other site
862967005273	ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding; Region: ProRS_anticodon_short; cd00861
862967005274	anticodon binding site; other site
862967005275	RIP metalloprotease RseP; Region: TIGR00054
862967005276	RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163
862967005277	active site
862967005278	Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020
862967005279	PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989
862967005280	protein binding site [polypeptide binding]; other site
862967005281	RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163
862967005282	putative substrate binding region [chemical binding]; other site
862967005283	CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575
862967005284	Cytidylyltransferase family; Region: CTP_transf_1; pfam01148
862967005285	Undecaprenyl pyrophosphate synthase [Lipid metabolism]; Region: UppS; COG0020
862967005286	Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cd00475
862967005287	catalytic residue [active]
862967005288	putative FPP diphosphate  binding site; other site
862967005289	putative FPP binding hydrophobic cleft; other site
862967005290	dimer interface [polypeptide binding]; other site
862967005291	putative IPP diphosphate binding site; other site
862967005292	preprotein translocase subunit YajC; Validated; Region: yajC; PRK06531
862967005293	Transketolase [Carbohydrate transport and metabolism]; Region: TktA; COG0021
862967005294	Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012
862967005295	TPP-binding site [chemical binding]; other site
862967005296	dimer interface [polypeptide binding]; other site
862967005297	Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033
862967005298	PYR/PP interface [polypeptide binding]; other site
862967005299	dimer interface [polypeptide binding]; other site
862967005300	TPP binding site [chemical binding]; other site
862967005301	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
862967005302	putative L-ascorbate 6-phosphate lactonase; Provisional; Region: PRK11709
862967005303	Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220
862967005304	Transcriptional antiterminator [Transcription]; Region: BglG; COG3711
862967005305	PRD domain; Region: PRD; pfam00874
862967005306	PRD domain; Region: PRD; pfam00874
862967005307	PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568
862967005308	active site
862967005309	P-loop; other site
862967005310	phosphorylation site [posttranslational modification]
862967005311	L-ribulose-5-phosphate 4-epimerase; Reviewed; Region: araD; PRK08193
862967005312	Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cd00398
862967005313	intersubunit interface [polypeptide binding]; other site
862967005314	active site
862967005315	Zn2+ binding site [ion binding]; other site
862967005316	putative L-xylulose 5-phosphate 3-epimerase; Reviewed; Region: PRK13210
862967005317	AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cd00019
862967005318	AP (apurinic/apyrimidinic) site pocket; other site
862967005319	DNA interaction; other site
862967005320	Metal-binding active site; metal-binding site
862967005321	3-Keto-L-gulonate 6-phosphate decarboxylase (KGPDC) and D-arabino-3-hexulose-6-phosphate synthase (HPS). KGPDC catalyzes the formation of L-xylulose 5-phosphate and carbon dioxide from 3-keto-L-gulonate 6-phosphate as part of the anaerobic pathway for...; Region: KGPDC_HPS; cd04726
862967005322	active site
862967005323	dimer interface [polypeptide binding]; other site
862967005324	magnesium binding site [ion binding]; other site
862967005325	PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211
862967005326	active site
862967005327	phosphorylation site [posttranslational modification]
862967005328	PTS_IIB_ascorbate: subunit IIB of enzyme II (EII) of the L-ascorbate-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is an L-ascorbate-specific permease with two cytoplasmic subunits (IIA and IIB) and a...; Region: PTS_IIB_ascorbate; cd05563
862967005329	active site
862967005330	P-loop; other site
862967005331	phosphorylation site [posttranslational modification]
862967005332	PTS system ascorbate-specific transporter subunit IIC; Reviewed; Region: PRK12997
862967005333	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
862967005334	ATPases associated with a variety of cellular activities; Region: AAA; smart00382
862967005335	Walker A motif; other site
862967005336	ATP binding site [chemical binding]; other site
862967005337	Walker B motif; other site
862967005338	arginine finger; other site
862967005339	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
862967005340	Walker A motif; other site
862967005341	ATP binding site [chemical binding]; other site
862967005342	Walker B motif; other site
862967005343	arginine finger; other site
862967005344	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431
862967005345	glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331
862967005346	Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans).  The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714
862967005347	glutaminase active site [active]
862967005348	SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008
862967005349	dimer interface [polypeptide binding]; other site
862967005350	active site
862967005351	SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009
862967005352	dimer interface [polypeptide binding]; other site
862967005353	active site
862967005354	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012
862967005355	propionate/acetate kinase; Provisional; Region: PRK12379
862967005356	nucleotide binding site [chemical binding]; other site
862967005357	butyrate kinase; Provisional; Region: PRK03011
862967005358	Adenine-specific DNA methylase [DNA replication, recombination, and repair]; Region: COG0827
862967005359	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
862967005360	S-adenosylmethionine binding site [chemical binding]; other site
862967005361	Competence protein ComGF [Intracellular trafficking and secretion]; Region: ComGF; COG4940
862967005362	Type II secretory pathway pseudopilin; Region: PulG; pfam11773
862967005363	Competence protein ComGC [Intracellular trafficking and secretion]; Region: ComGC; COG4537
862967005364	Type II secretory pathway, component PulF [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulF; COG1459
862967005365	Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482
862967005366	Heme-copper oxidase subunit I.  Heme-copper oxidases are transmembrane protein complexes in the respiratory chains of prokaryotes and mitochondria which catalyze the reduction of O2 and simultaneously pump protons across the membrane.  The superfamily is...; Region: Heme_Cu_Oxidase_I; cl00275
862967005367	Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482
862967005368	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
862967005369	Walker A motif; other site
862967005370	ATP binding site [chemical binding]; other site
862967005371	Walker B motif; other site
862967005372	Protein of unknown function (DUF1033); Region: DUF1033; pfam06279
862967005373	Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174
862967005374	Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951
862967005375	Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120
862967005376	Helix-Turn-Helix DNA binding domain of GlnR-like transcription regulators; Region: HTH_GlnR-like; cd01105
862967005377	MerR HTH family regulatory protein; Region: MerR_1; pfam13411
862967005378	DNA binding residues [nucleotide binding]
862967005379	putative dimer interface [polypeptide binding]; other site
862967005380	Predicted membrane protein [Function unknown]; Region: COG4129
862967005381	Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515
862967005382	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
862967005383	Surface antigen [General function prediction only]; Region: COG3942
862967005384	CHAP domain; Region: CHAP; pfam05257
862967005385	Streptococcal surface antigen repeat; Region: Strep_SA_rep; pfam06696
862967005386	Streptococcal surface antigen repeat; Region: Strep_SA_rep; pfam06696
862967005387	Glucan-binding protein C; Region: GbpC; pfam08363
862967005388	adhesin isopeptide-forming domain, sspB-C2 type; Region: isopep_sspB_C2; TIGR04228
862967005389	Gram positive anchor; Region: Gram_pos_anchor; pfam00746
862967005390	phosphoglycerate kinase; Provisional; Region: pgk; PRK00073
862967005391	Phosphoglycerate kinase; Region: PGK; pfam00162
862967005392	substrate binding site [chemical binding]; other site
862967005393	hinge regions; other site
862967005394	ADP binding site [chemical binding]; other site
862967005395	catalytic site [active]
862967005396	DNA-directed RNA polymerase subunit beta'; Provisional; Region: PRK00566
862967005397	RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997
862967005398	RNA polymerase I subunit A N-terminus; Region: RPOLA_N; smart00663
862967005399	RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983
862967005400	RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000
862967005401	Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655
862967005402	Rpb1 (beta') - Rpb6 (omega) interaction site [polypeptide binding]; other site
862967005403	G-loop; other site
862967005404	Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655
862967005405	DNA binding site [nucleotide binding]
862967005406	Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site
862967005407	RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585
862967005408	RNA polymerase Rpb2, domain 2; Region: RNA_pol_Rpb2_2; pfam04561
862967005409	DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405
862967005410	RNA polymerase Rpb2, domain 2; Region: RNA_pol_Rpb2_2; pfam04561
862967005411	RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653
862967005412	RPB1 interaction site [polypeptide binding]; other site
862967005413	RPB10 interaction site [polypeptide binding]; other site
862967005414	RPB11 interaction site [polypeptide binding]; other site
862967005415	RPB3 interaction site [polypeptide binding]; other site
862967005416	RPB12 interaction site [polypeptide binding]; other site
862967005417	penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074
862967005418	Transglycosylase; Region: Transgly; pfam00912
862967005419	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760
862967005420	tyrosyl-tRNA synthetase; Validated; Region: PRK05912
862967005421	catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805
862967005422	active site
862967005423	HIGH motif; other site
862967005424	dimer interface [polypeptide binding]; other site
862967005425	KMSKS motif; other site
862967005426	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
862967005427	RNA binding surface [nucleotide binding]; other site
862967005428	23S rRNA methyltransferase A; Provisional; Region: rrmA; PRK11088
862967005429	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
862967005430	S-adenosylmethionine binding site [chemical binding]; other site
862967005431	Rhomboid family; Region: Rhomboid; pfam01694
862967005432	5,10-methenyltetrahydrofolate synthetase; Region: MTHFS_bact; TIGR02727
862967005433	5-formyltetrahydrofolate cyclo-ligase family; Region: 5-FTHF_cyc-lig; pfam01812
862967005434	M20 Peptidase Aminoacyclase-1 YkuR-like proteins, including YkuR and Ama/HipO/HyuC proteins; Region: M20_Acy1_YkuR_like; cd05670
862967005435	Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473
862967005436	metal binding site [ion binding]; metal-binding site
862967005437	putative dimer interface [polypeptide binding]; other site
862967005438	Tetrahydrodipicolinate succinyltransferase N-terminal; Region: DapH_N; pfam08503
862967005439	2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-acetyltransferase; Region: DapD_Ac; TIGR03532
862967005440	2,3,4,5-tetrahydropyridine-2,6-dicarboxylate (THDP) N-succinyltransferase (also called THP succinyltransferase): THDP N-succinyltransferase catalyzes the conversion of tetrahydrodipicolinate and succinyl-CoA to N-succinyltetrahydrodipicolinate and CoA; Region: LbH_THP_succinylT; cd03350
862967005441	trimer interface [polypeptide binding]; other site
862967005442	active site
862967005443	substrate binding site [chemical binding]; other site
862967005444	CoA binding site [chemical binding]; other site
862967005445	glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406
862967005446	catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808
862967005447	active site
862967005448	HIGH motif; other site
862967005449	catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808
862967005450	active site
862967005451	KMSKS motif; other site
862967005452	DNA repair protein RadA; Provisional; Region: PRK11823
862967005453	Sms (bacterial radA) DNA repair protein. This protein is not related to archael radA any more than is to other RecA-like NTPases. Sms has a role in recombination and recombinational repair and is responsible for the stabilization or processing of...; Region: Sms; cd01121
862967005454	Walker A motif/ATP binding site; other site
862967005455	ATP binding site [chemical binding]; other site
862967005456	Walker B motif; other site
862967005457	Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541
862967005458	Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431
862967005459	catalytic triad [active]
862967005460	conserved cis-peptide bond; other site
862967005461	Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557
862967005462	trimer interface [polypeptide binding]; other site
862967005463	active site
862967005464	Microcin C7 self-immunity protein determines resistance to exogenous microcin C7; Region: Peptidase_S66_mccF_like; cd07062
862967005465	putative dimer interface [polypeptide binding]; other site
862967005466	catalytic triad [active]
862967005467	NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094
862967005468	NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210
862967005469	NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479
862967005470	Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541
862967005471	dTDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: RfbA; COG1209
862967005472	active site
862967005473	tetramer interface; other site
862967005474	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
862967005475	DNA binding site [nucleotide binding]
862967005476	active site
862967005477	Int/Topo IB signature motif; other site
862967005478	Domain of unknown function (DUF955); Region: DUF955; pfam06114
862967005479	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
862967005480	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
862967005481	non-specific DNA binding site [nucleotide binding]; other site
862967005482	salt bridge; other site
862967005483	sequence-specific DNA binding site [nucleotide binding]; other site
862967005484	PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in bacteria and archaea; Region: PEBP_bact_arch; cd00865
862967005485	substrate binding site [chemical binding]; other site
862967005486	RelB antitoxin; Region: RelB; cl01171
862967005487	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3041
862967005488	FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580
862967005489	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
862967005490	non-specific DNA binding site [nucleotide binding]; other site
862967005491	salt bridge; other site
862967005492	sequence-specific DNA binding site [nucleotide binding]; other site
862967005493	Putative phage replication protein RstA [DNA replication, recombination, and repair]; Region: COG2946
862967005494	Replication initiation factor; Region: Rep_trans; pfam02486
862967005495	Conjugative transposon protein TcpC; Region: TpcC; pfam12642
862967005496	TcpE family; Region: TcpE; pfam12648
862967005497	FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580
862967005498	AAA-like domain; Region: AAA_10; pfam12846
862967005499	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
862967005500	catalytic residue [active]
862967005501	CHAP domain; Region: CHAP; pfam05257
862967005502	Domain of Unknown Function with PDB structure (DUF3850); Region: DUF3850; pfam12961
862967005503	Domain of unknown function (DUF771); Region: DUF771; pfam05595
862967005504	phiLC3 phage and phage-related integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes various bacterial (mainly gram positive) and phage integrases, including those similar to Lactococcus...; Region: INT_phiLC3_C; cd01189
862967005505	Int/Topo IB signature motif; other site
862967005506	50S ribosomal protein L17; Validated; Region: rplQ; PRK05591
862967005507	DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182
862967005508	N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928
862967005509	alphaNTD homodimer interface [polypeptide binding]; other site
862967005510	alphaNTD - beta interaction site [polypeptide binding]; other site
862967005511	alphaNTD - beta' interaction site [polypeptide binding]; other site
862967005512	Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118
862967005513	30S ribosomal protein S11; Validated; Region: PRK05309
862967005514	Ribosomal protein S13 [Translation, ribosomal structure and biogenesis]; Region: RpsM; COG0099
862967005515	30S ribosomal protein S13; Region: bact_S13; TIGR03631
862967005516	Ribosomal protein L36; Region: Ribosomal_L36; pfam00444
862967005517	S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451
862967005518	rRNA binding site [nucleotide binding]; other site
862967005519	predicted 30S ribosome binding site; other site
862967005520	adenylate kinase; Reviewed; Region: adk; PRK00279
862967005521	Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428
862967005522	AMP-binding site [chemical binding]; other site
862967005523	ATP-AMP (Ap5A)-binding site [chemical binding]; other site
862967005524	preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204
862967005525	SecY translocase; Region: SecY; pfam00344
862967005526	50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592
862967005527	30S ribosomal protein S5; Validated; Region: rpsE; PRK00550
862967005528	Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333
862967005529	Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719
862967005530	Ribosomal L18/L5e:  L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432
862967005531	5S rRNA interface [nucleotide binding]; other site
862967005532	L27 interface [polypeptide binding]; other site
862967005533	23S rRNA interface [nucleotide binding]; other site
862967005534	L5 interface [polypeptide binding]; other site
862967005535	50S ribosomal protein L6; Validated; Region: rplF; PRK05498
862967005536	Ribosomal protein L6; Region: Ribosomal_L6; pfam00347
862967005537	Ribosomal protein L6; Region: Ribosomal_L6; pfam00347
862967005538	30S ribosomal protein S8; Validated; Region: rpsH; PRK00136
862967005539	30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08061
862967005540	50S ribosomal protein L5; Validated; Region: rplE; PRK00010
862967005541	Ribosomal protein L5; Region: Ribosomal_L5; pfam00281
862967005542	ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673
862967005543	50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004
862967005544	KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089
862967005545	RNA binding site [nucleotide binding]; other site
862967005546	50S ribosomal protein L14; Validated; Region: rplN; PRK05483
862967005547	30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610
862967005548	Ribosomal L29 protein/HIP.  L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals.  L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427
862967005549	23S rRNA interface [nucleotide binding]; other site
862967005550	putative translocon interaction site; other site
862967005551	signal recognition particle (SRP54) interaction site; other site
862967005552	L23 interface [polypeptide binding]; other site
862967005553	trigger factor interaction site; other site
862967005554	Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433
862967005555	23S rRNA interface [nucleotide binding]; other site
862967005556	5S rRNA interface [nucleotide binding]; other site
862967005557	putative antibiotic binding site [chemical binding]; other site
862967005558	L25 interface [polypeptide binding]; other site
862967005559	L27 interface [polypeptide binding]; other site
862967005560	30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310
862967005561	K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3  is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel.  The KH...; Region: 30S_S3_KH; cd02412
862967005562	G-X-X-G motif; other site
862967005563	Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189
862967005564	Ribosomal protein L22/L17e.  L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit.  It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336
862967005565	putative translocon binding site; other site
862967005566	protein-rRNA interface [nucleotide binding]; other site
862967005567	30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357
862967005568	50S ribosomal protein L2; Validated; Region: rplB; PRK09374
862967005569	Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181
862967005570	Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947
862967005571	50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738
862967005572	50S ribosomal protein L4; Provisional; Region: rplD; PRK05319
862967005573	50S ribosomal protein L3; Validated; Region: rplC; PRK00001
862967005574	30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596
862967005575	Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190
862967005576	active site
862967005577	queuine tRNA-ribosyltransferase; Provisional; Region: tgt; PRK00112
862967005578	Queuine/archaeosine tRNA-ribosyltransferase [Translation, ribosomal structure and biogenesis]; Region: Tgt; COG0343
862967005579	Protein of unknown function (DUF975); Region: DUF975; cl10504
862967005580	hypothetical protein; Provisional; Region: PRK06762
862967005581	Predicted CoA-binding protein [General function prediction only]; Region: COG1832
862967005582	DNA polymerase I; Provisional; Region: PRK05755
862967005583	PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859
862967005584	active site
862967005585	metal binding site 1 [ion binding]; metal-binding site
862967005586	putative 5' ssDNA interaction site; other site
862967005587	metal binding site 3; metal-binding site
862967005588	metal binding site 2 [ion binding]; metal-binding site
862967005589	H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898
862967005590	putative DNA binding site [nucleotide binding]; other site
862967005591	putative metal binding site [ion binding]; other site
862967005592	inactive DEDDy 3'-5' exonuclease domain of Bacillus stearothermophilus DNA polymerase I and similar family-A DNA polymerases; Region: DNA_polA_I_Bacillus_like_exo; cd06140
862967005593	Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637
862967005594	active site
862967005595	DNA binding site [nucleotide binding]
862967005596	catalytic site [active]
862967005597	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
862967005598	catalytic core [active]
862967005599	haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282
862967005600	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cl17915
862967005601	Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263
862967005602	bifunctional PTS system maltose and glucose-specific transporter subunits IICB; Provisional; Region: PRK10110
862967005603	PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212
862967005604	active site turn [active]
862967005605	phosphorylation site [posttranslational modification]
862967005606	transcriptional regulator MurR; Provisional; Region: PRK15482
862967005607	Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418
862967005608	RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013
862967005609	putative active site [active]
862967005610	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
862967005611	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
862967005612	dimer interface [polypeptide binding]; other site
862967005613	phosphorylation site [posttranslational modification]
862967005614	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
862967005615	ATP binding site [chemical binding]; other site
862967005616	Mg2+ binding site [ion binding]; other site
862967005617	G-X-G motif; other site
862967005618	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
862967005619	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
862967005620	active site
862967005621	phosphorylation site [posttranslational modification]
862967005622	intermolecular recognition site; other site
862967005623	dimerization interface [polypeptide binding]; other site
862967005624	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
862967005625	DNA binding site [nucleotide binding]
862967005626	Fibronectin-binding repeat; Region: SSURE; pfam11966
862967005627	Fibronectin-binding repeat; Region: SSURE; pfam11966
862967005628	Fibronectin-binding repeat; Region: SSURE; pfam11966
862967005629	Fibronectin-binding repeat; Region: SSURE; pfam11966
862967005630	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
862967005631	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
862967005632	NAD(P) binding site [chemical binding]; other site
862967005633	active site
862967005634	CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516
862967005635	substrate binding site; other site
862967005636	dimer interface; other site
862967005637	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
862967005638	Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_d; cd04196
862967005639	Probable Catalytic site; other site
862967005640	LicD family; Region: LicD; cl01378
862967005641	Glycosyltransferases, probably involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: COG1215
862967005642	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
862967005643	active site
862967005644	Bacterial sugar transferase; Region: Bac_transf; pfam02397
862967005645	aminotransferase, LLPSF_NHT_00031 family; Region: NHT_00031; TIGR04181
862967005646	3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616
862967005647	inhibitor-cofactor binding pocket; inhibition site
862967005648	pyridoxal 5'-phosphate binding site [chemical binding]; other site
862967005649	catalytic residue [active]
862967005650	Predicted nucleoside-diphosphate sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG1086
862967005651	7TM diverse intracellular signalling; Region: 7TMR-DISM_7TM; pfam07695
862967005652	UDP-Glcnac (UDP-linked N-acetylglucosamine) inverting 4,6-dehydratase, extended (e) SDRs; Region: UDP_invert_4-6DH_SDR_e; cd05237
862967005653	NAD(P) binding site [chemical binding]; other site
862967005654	homodimer interface [polypeptide binding]; other site
862967005655	substrate binding site [chemical binding]; other site
862967005656	active site
862967005657	capsular exopolysaccharide family; Region: eps_fam; TIGR01007
862967005658	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
862967005659	polysaccharide export protein, MPA1 family, Gram-positive type; Region: polys_exp_MPA1; TIGR01006
862967005660	Capsular polysaccharide biosynthesis protein [Cell envelope biogenesis, outer membrane]; Region: COG3944
862967005661	Capsular polysaccharide biosynthesis protein [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: CapC; COG4464
862967005662	DNA polymerase processivity factor; Region: DNA_PPF; pfam02916
862967005663	Cell envelope-related transcriptional attenuator domain; Region: LytR_cpsA_psr; pfam03816
862967005664	4Fe-4S single cluster domain; Region: Fer4_12; pfam13353
862967005665	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
862967005666	FeS/SAM binding site; other site
862967005667	Predicted acetyltransferase [General function prediction only]; Region: COG3981
862967005668	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
862967005669	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
862967005670	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
862967005671	Coenzyme A binding pocket [chemical binding]; other site
862967005672	anaerobic ribonucleoside triphosphate reductase; Provisional; Region: PRK09263
862967005673	ATP cone domain; Region: ATP-cone; pfam03477
862967005674	Class III ribonucleotide reductase; Region: RNR_III; cd01675
862967005675	effector binding site; other site
862967005676	active site
862967005677	Zn binding site [ion binding]; other site
862967005678	glycine loop; other site
862967005679	Phospholipase_D-nuclease N-terminal; Region: PLDc_N; pfam13396
862967005680	Phosphatidylserine/phosphatidylglycerophosphate/car diolipin synthases and related enzymes [Lipid metabolism]; Region: Cls; COG1502
862967005681	Putative catalytic domain, repeat 1, of Streptococcus mutans uncharacterized protein SMU_988 and similar proteins; Region: PLDc_SMU_988_like_1; cd09154
862967005682	putative active site [active]
862967005683	catalytic site [active]
862967005684	Putative catalytic domain, repeat 2, of Streptococcus mutans uncharacterized protein SMU_988 and similar proteins; Region: PLDc_SMU_988_like_2; cd09160
862967005685	putative active site [active]
862967005686	catalytic site [active]
862967005687	Bacterial lipoprotein; Region: DUF3642; pfam12182
862967005688	folylpolyglutamate synthase/dihydrofolate synthase; Region: folC; TIGR01499
862967005689	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
862967005690	hypothetical protein; Provisional; Region: PRK13678
862967005691	Holliday junction resolvase-like protein; Reviewed; Region: PRK00109
862967005692	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4472
862967005693	Protein of unknown function (DUF1307); Region: DUF1307; cl01981
862967005694	Arsenate Reductase (ArsC) family, Spx subfamily; Spx is a unique RNA polymerase (RNAP)-binding protein present in bacilli and some mollicutes. It inhibits transcription by binding to the C-terminal domain of the alpha subunit of RNAP, disrupting complex...; Region: ArsC_Spx; cd03032
862967005695	ArsC family; Region: ArsC; pfam03960
862967005696	putative catalytic residues [active]
862967005697	thiol/disulfide switch; other site
862967005698	recombinase A; Provisional; Region: recA; PRK09354
862967005699	RecA is a  bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response.  RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983
862967005700	hexamer interface [polypeptide binding]; other site
862967005701	Walker A motif; other site
862967005702	ATP binding site [chemical binding]; other site
862967005703	Walker B motif; other site
862967005704	competence damage-inducible protein A; Provisional; Region: PRK00549
862967005705	Competence-damaged protein. CinA is the first gene in the competence- inducible (cin) operon and is thought to be specifically required at some stage in the process of transformation. This domain is closely related to a domain, found in a variety of...; Region: cinA; cd00885
862967005706	putative MPT binding site; other site
862967005707	Uncharacterized protein (competence- and mitomycin-induced) [General function prediction only]; Region: CinA; COG1546
862967005708	Cna protein B-type domain; Region: Cna_B; pfam05738
862967005709	Repeat unit of collagen-binding protein domain B; Region: CollagenBindB; cd00222
862967005710	domain interaction interfaces [polypeptide binding]; other site
862967005711	streptococcal pilin isopeptide linkage domain; Region: strep_pil_rpt; TIGR03786
862967005712	Repeat unit of collagen-binding protein domain B; Region: CollagenBindB; cd00222
862967005713	domain interaction interfaces [polypeptide binding]; other site
862967005714	Repeat unit of collagen-binding protein domain B; Region: CollagenBindB; cd00222
862967005715	domain interaction interfaces [polypeptide binding]; other site
862967005716	Repeat unit of collagen-binding protein domain B; Region: CollagenBindB; cd00222
862967005717	domain interaction interfaces [polypeptide binding]; other site
862967005718	Repeat unit of collagen-binding protein domain B; Region: CollagenBindB; cd00222
862967005719	domain interaction interfaces [polypeptide binding]; other site
862967005720	Repeat unit of collagen-binding protein domain B; Region: CollagenBindB; cd00222
862967005721	domain interaction interfaces [polypeptide binding]; other site
862967005722	Repeat unit of collagen-binding protein domain B; Region: CollagenBindB; cd00222
862967005723	domain interaction interfaces [polypeptide binding]; other site
862967005724	CAAX protease self-immunity; Region: Abi; pfam02517
862967005725	Methyladenine glycosylase; Region: Adenine_glyco; pfam03352
862967005726	Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116
862967005727	RuvA N terminal domain; Region: RuvA_N; pfam01330
862967005728	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
862967005729	non-specific DNA binding site [nucleotide binding]; other site
862967005730	salt bridge; other site
862967005731	sequence-specific DNA binding site [nucleotide binding]; other site
862967005732	RDD family; Region: RDD; pfam06271
862967005733	DNA mismatch repair protein; Reviewed; Region: mutL; PRK00095
862967005734	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
862967005735	ATP binding site [chemical binding]; other site
862967005736	Mg2+ binding site [ion binding]; other site
862967005737	G-X-G motif; other site
862967005738	MutL_Trans: transducer domain, having a ribosomal S5 domain 2-like fold, conserved in the C-terminal domain of DNA mismatch repair (MutL/MLH1/PMS2) family. This transducer domain is homologous to the second domain of the DNA gyrase B subunit, which is...; Region: MutL_Trans; cd00782
862967005739	ATP binding site [chemical binding]; other site
862967005740	MutL C terminal dimerisation domain; Region: MutL_C; pfam08676
862967005741	Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279
862967005742	LytTr DNA-binding domain; Region: LytTR; smart00850
862967005743	Protein of unknown function (DUF3021); Region: DUF3021; pfam11457
862967005744	DNA mismatch repair protein MutS; Provisional; Region: PRK05399
862967005745	MutS domain I; Region: MutS_I; pfam01624
862967005746	MutS domain II; Region: MutS_II; pfam05188
862967005747	MutS domain III; Region: MutS_III; pfam05192
862967005748	ATP-binding cassette domain of MutS1 homolog; Region: ABC_MutS1; cd03284
862967005749	Walker A/P-loop; other site
862967005750	ATP binding site [chemical binding]; other site
862967005751	Q-loop/lid; other site
862967005752	ABC transporter signature motif; other site
862967005753	Walker B; other site
862967005754	D-loop; other site
862967005755	H-loop/switch region; other site
862967005756	Arginine repressor, DNA binding domain; Region: Arg_repressor; pfam01316
862967005757	arginine repressor; Region: argR_whole; TIGR01529
862967005758	Arginine repressor, C-terminal domain; Region: Arg_repressor_C; pfam02863
862967005759	arginyl-tRNA synthetase; Reviewed; Region: PRK12451
862967005760	Arginyl tRNA synthetase N terminal dom; Region: Arg_tRNA_synt_N; smart01016
862967005761	catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671
862967005762	active site
862967005763	HIGH motif; other site
862967005764	KMSK motif region; other site
862967005765	Anticodon-binding domain of arginyl tRNA synthetases; Region: Anticodon_Ia_Arg; cd07956
862967005766	tRNA binding surface [nucleotide binding]; other site
862967005767	anticodon binding site; other site
862967005768	NrdI Flavodoxin like; Region: Flavodoxin_NdrI; cl17293
862967005769	glycogen/starch/alpha-glucan phosphorylases; Region: P_ylase; TIGR02093
862967005770	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
862967005771	4-alpha-glucanotransferase; Provisional; Region: PRK14508
862967005772	Maltose-binding periplasmic proteins/domains [Carbohydrate transport and metabolism]; Region: MalE; COG2182
862967005773	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
862967005774	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
862967005775	dimer interface [polypeptide binding]; other site
862967005776	conserved gate region; other site
862967005777	putative PBP binding loops; other site
862967005778	ABC-ATPase subunit interface; other site
862967005779	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
862967005780	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
862967005781	dimer interface [polypeptide binding]; other site
862967005782	conserved gate region; other site
862967005783	putative PBP binding loops; other site
862967005784	ABC-ATPase subunit interface; other site
862967005785	Predicted integral membrane protein [Function unknown]; Region: COG5521
862967005786	Transcriptional regulators [Transcription]; Region: PurR; COG1609
862967005787	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
862967005788	DNA binding site [nucleotide binding]
862967005789	domain linker motif; other site
862967005790	Ligand-binding domain of uncharacterized transcription regulator ycjW which is a member of the LacI-GalR family repressors; Region: PBP1_ycjW_transcription_regulator_like; cd06294
862967005791	putative dimerization interface [polypeptide binding]; other site
862967005792	putative ligand binding site [chemical binding]; other site
862967005793	pullulanase, type I; Region: pulA_typeI; TIGR02104
862967005794	Early set domain associated with the catalytic domain of pullulanase (also called dextrinase and alpha-dextrin endo-1,6-alpha glucosidase); Region: E_set_Pullulanase; cd02860
862967005795	Alpha amylase catalytic domain found in Pullulanase (also called dextrinase; alpha-dextrin endo-1,6-alpha glucosidase), limit dextrinase, and related proteins; Region: AmyAc_Pullulanase_LD-like; cd11341
862967005796	Ca binding site [ion binding]; other site
862967005797	active site
862967005798	catalytic site [active]
862967005799	Uncharacterized conserved protein [Function unknown]; Region: COG1284
862967005800	Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588
862967005801	Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588
862967005802	Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035
862967005803	aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476
862967005804	EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317
862967005805	dimer interface [polypeptide binding]; other site
862967005806	anticodon binding site; other site
862967005807	Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777
862967005808	homodimer interface [polypeptide binding]; other site
862967005809	motif 1; other site
862967005810	active site
862967005811	motif 2; other site
862967005812	GAD domain; Region: GAD; pfam02938
862967005813	Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA.   PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268
862967005814	active site
862967005815	motif 3; other site
862967005816	histidyl-tRNA synthetase; Reviewed; Region: hisS; PRK00037
862967005817	Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773
862967005818	dimer interface [polypeptide binding]; other site
862967005819	motif 1; other site
862967005820	active site
862967005821	motif 2; other site
862967005822	motif 3; other site
862967005823	HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859
862967005824	anticodon binding site; other site
862967005825	50S ribosomal protein L32; Validated; Region: rpmF; PRK01110
862967005826	50S ribosomal protein L33; Validated; Region: rpmG; PRK00595
862967005827	Predicted permease, cadmium resistance protein [Inorganic ion transport and metabolism]; Region: CadD; COG4300
862967005828	Cadmium resistance transporter; Region: Cad; pfam03596
862967005829	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
862967005830	putative DNA binding site [nucleotide binding]; other site
862967005831	putative Zn2+ binding site [ion binding]; other site
862967005832	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
862967005833	non-specific DNA binding site [nucleotide binding]; other site
862967005834	salt bridge; other site
862967005835	sequence-specific DNA binding site [nucleotide binding]; other site
862967005836	RNA polymerase sigma factor; Provisional; Region: PRK12519
862967005837	DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674
862967005838	FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580
862967005839	Plasmid replication protein; Region: Rep_2; pfam01719
862967005840	MerR HTH family regulatory protein; Region: MerR_1; pfam13411
862967005841	phiLC3 phage and phage-related integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes various bacterial (mainly gram positive) and phage integrases, including those similar to Lactococcus...; Region: INT_phiLC3_C; cd01189
862967005842	Int/Topo IB signature motif; other site
862967005843	Serine/threonine protein kinase [General function prediction only / Signal transduction mechanisms / Transcription / DNA replication, recombination, and repair]; Region: SPS1; COG0515
862967005844	Protein Kinases, catalytic domain; Region: PKc_like; cl09925
862967005845	active site
862967005846	ATP binding site [chemical binding]; other site
862967005847	substrate binding site [chemical binding]; other site
862967005848	activation loop (A-loop); other site
862967005849	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
862967005850	non-specific DNA binding site [nucleotide binding]; other site
862967005851	salt bridge; other site
862967005852	sequence-specific DNA binding site [nucleotide binding]; other site
862967005853	transcriptional activator, Rgg/GadR/MutR family, C-terminal domain; Region: RGG_Cterm; TIGR01716
862967005854	heavy metal translocating P-type ATPase; Region: ATPase-IB_hvy; TIGR01525
862967005855	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
862967005856	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
862967005857	motif II; other site
862967005858	Cyanate permease [Inorganic ion transport and metabolism]; Region: CynX; COG2807
862967005859	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
862967005860	putative substrate translocation pore; other site
862967005861	Alkyladenine DNA glycosylase catalyzes the first step in base excision repair; Region: AAG; cd00540
862967005862	active site
862967005863	DNA binding site [nucleotide binding]
862967005864	Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349
862967005865	helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420
862967005866	DeoR C terminal sensor domain; Region: DeoRC; pfam00455
862967005867	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
862967005868	haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282
862967005869	active site
862967005870	motif I; other site
862967005871	motif II; other site
862967005872	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
862967005873	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
862967005874	Protein involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein) [Cell envelope biogenesis, outer membrane]; Region: DltD; COG3966
862967005875	DltD N-terminal region; Region: DltD_N; pfam04915
862967005876	DltD central region; Region: DltD_M; pfam04918
862967005877	DltD C-terminal region; Region: DltD_C; pfam04914
862967005878	D-alanine--poly(phosphoribitol) ligase subunit 2; Validated; Region: PRK05087
862967005879	D-alanyl-lipoteichoic acid biosynthesis protein DltB; Region: LTA_dltB; TIGR04091
862967005880	D-alanine--poly(phosphoribitol) ligase subunit 1; Provisional; Region: PRK04813
862967005881	D-alanine:D-alanyl carrier protein ligase (DltA); Region: DltA; cd05945
862967005882	acyl-activating enzyme (AAE) consensus motif; other site
862967005883	AMP binding site [chemical binding]; other site
862967005884	D-Ala-teichoic acid biosynthesis protein; Region: DUF3687; pfam12459
862967005885	Predicted transcriptional regulators [Transcription]; Region: COG1695
862967005886	Transcriptional regulator PadR-like family; Region: PadR; cl17335
862967005887	Predicted membrane protein [Function unknown]; Region: COG4709
862967005888	Domain of unknown function (DUF4097); Region: DUF4097; pfam13349
862967005889	Domain of unknown function (DUF4098); Region: DUF4098; pfam13345
862967005890	Predicted hydrolase (HAD superfamily) [General function prediction only]; Region: COG1011
862967005891	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
862967005892	motif II; other site
862967005893	Domain of unknown function (DUF4353); Region: DUF4353; pfam14262
862967005894	Polyphosphate(polyP) polymerase domain of yeast vacuolar transport chaperone (VTC) proteins VTC-2, -3 and- 4, and similar proteins; Region: PolyPPase_VTC_like; cd07750
862967005895	putative metal binding residues [ion binding]; other site
862967005896	signature motif; other site
862967005897	dimer interface [polypeptide binding]; other site
862967005898	active site
862967005899	polyP binding site; other site
862967005900	substrate binding site [chemical binding]; other site
862967005901	acceptor-phosphate pocket; other site
862967005902	TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947
862967005903	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
862967005904	catalytic residues [active]
862967005905	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
862967005906	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
862967005907	non-specific DNA binding site [nucleotide binding]; other site
862967005908	salt bridge; other site
862967005909	sequence-specific DNA binding site [nucleotide binding]; other site
862967005910	haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282
862967005911	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
862967005912	active site
862967005913	motif I; other site
862967005914	motif II; other site
862967005915	haloacid dehalogenase-like hydrolase; Region: HAD; cl17202
862967005916	Predicted membrane protein [Function unknown]; Region: COG1511
862967005917	YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061
862967005918	YhgE/Pip C-terminal domain; Region: pip_yhgE_Cterm; TIGR03062
862967005919	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
862967005920	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
862967005921	30S ribosomal protein S4; Validated; Region: rpsD; PRK05327
862967005922	Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163
862967005923	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
862967005924	RNA binding surface [nucleotide binding]; other site
862967005925	Haloacid dehalogenase-like hydrolase; Region: HAD_2; pfam13419
862967005926	?-D-glucose-1-phosphatase; Provisional; Region: PRK09456
862967005927	Uncharacterized protein conserved in bacteria [Function unknown]; Region: Veg; COG4466
862967005928	replicative DNA helicase; Provisional; Region: PRK05748
862967005929	DnaB-like helicase N terminal domain; Region: DnaB; pfam00772
862967005930	DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the  chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984
862967005931	Walker A motif; other site
862967005932	ATP binding site [chemical binding]; other site
862967005933	Walker B motif; other site
862967005934	DNA binding loops [nucleotide binding]
862967005935	50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137
862967005936	Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281
862967005937	Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948
862967005938	Predicted signaling protein consisting of a modified GGDEF domain and a DHH domain [Signal transduction mechanisms]; Region: COG3887
862967005939	DHH family; Region: DHH; pfam01368
862967005940	DHHA1 domain; Region: DHHA1; pfam02272
862967005941	tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA; Validated; Region: PRK05192
862967005942	tRNA:m(5)U-54 methyltransferase; Region: gid_trmFO; TIGR00137
862967005943	GidA associated domain 3; Region: GIDA_assoc_3; pfam13932
862967005944	Predicted tRNA(5-methylaminomethyl-2-thiouridylate) methyltransferase, contains the PP-loop ATPase domain [Translation, ribosomal structure and biogenesis]; Region: TrmU; COG0482
862967005945	tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998
862967005946	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
862967005947	FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388
862967005948	L-serine dehydratase, iron-sulfur-dependent, beta subunit; Region: sda_beta; TIGR00719
862967005949	Serine dehydratase beta chain; Region: SDH_beta; pfam03315
862967005950	C-terminal ACT domain of the L-serine dehydratase (LSD), iron-sulfur-dependent, beta subunit; Region: ACT_LSD; cd04903
862967005951	putative L-serine binding site [chemical binding]; other site
862967005952	Serine dehydratase alpha chain; Region: SDH_alpha; cl12120
862967005953	L-serine deaminase [Amino acid transport and metabolism]; Region: SdaA; COG1760
862967005954	Predicted phosphatases [General function prediction only]; Region: Gph; COG0546
862967005955	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
862967005956	motif II; other site
862967005957	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
862967005958	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
862967005959	N-acetyl-D-glucosamine binding site [chemical binding]; other site
862967005960	catalytic residue [active]
862967005961	ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619
862967005962	cobalt transporter ATP-binding subunit; Provisional; Region: cbiO; PRK13649
862967005963	First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225
862967005964	Walker A/P-loop; other site
862967005965	ATP binding site [chemical binding]; other site
862967005966	Q-loop/lid; other site
862967005967	ABC transporter signature motif; other site
862967005968	Walker B; other site
862967005969	D-loop; other site
862967005970	H-loop/switch region; other site
862967005971	cobalt transporter ATP-binding subunit; Provisional; Region: cbiO; PRK13650
862967005972	First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225
862967005973	Walker A/P-loop; other site
862967005974	ATP binding site [chemical binding]; other site
862967005975	Q-loop/lid; other site
862967005976	ABC transporter signature motif; other site
862967005977	Walker B; other site
862967005978	D-loop; other site
862967005979	H-loop/switch region; other site
862967005980	CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453
862967005981	Predicted transcriptional regulator contains Xre-like HTH domain [Function unknown]; Region: COG1426
862967005982	Helix-turn-helix domain; Region: HTH_25; pfam13413
862967005983	Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612
862967005984	Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675
862967005985	Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193
862967005986	Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612
862967005987	Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193
862967005988	S4 domain protein YaaA; Region: YaaA_near_RecF; TIGR02988
862967005989	recombination protein F; Reviewed; Region: recF; PRK00064
862967005990	ATP-binding cassette domain of RecF; Region: ABC_RecF; cd03242
862967005991	Walker A/P-loop; other site
862967005992	ATP binding site [chemical binding]; other site
862967005993	Q-loop/lid; other site
862967005994	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
862967005995	ABC transporter signature motif; other site
862967005996	Walker B; other site
862967005997	D-loop; other site
862967005998	H-loop/switch region; other site
862967005999	inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567
862967006000	TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186
862967006001	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein.  IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a...; Region: CBS_pair_IMPDH; cd04601
862967006002	IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381
862967006003	active site
862967006004	tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282
862967006005	catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806
862967006006	active site
862967006007	HIGH motif; other site
862967006008	dimer interface [polypeptide binding]; other site
862967006009	KMSKS motif; other site
862967006010	UDP-glucose 4-epimerase [Cell envelope biogenesis, outer membrane]; Region: GalE; COG1087
862967006011	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
862967006012	NAD(P) binding site [chemical binding]; other site
862967006013	active site
862967006014	Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311
862967006015	substrate binding site [chemical binding]; other site
862967006016	dimer interface [polypeptide binding]; other site
862967006017	catalytic triad [active]
862967006018	Flavodoxin-like fold; Region: Flavodoxin_2; pfam02525
862967006019	ABC transporter ATP-binding protein; Provisional; Region: PRK15064
862967006020	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
862967006021	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
862967006022	ABC transporter; Region: ABC_tran_2; pfam12848
862967006023	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
862967006024	Predicted membrane protein [Function unknown]; Region: COG4485
862967006025	Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279
862967006026	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
862967006027	active site
862967006028	phosphorylation site [posttranslational modification]
862967006029	intermolecular recognition site; other site
862967006030	dimerization interface [polypeptide binding]; other site
862967006031	LytTr DNA-binding domain; Region: LytTR; pfam04397
862967006032	Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518
862967006033	ATP binding site [chemical binding]; other site
862967006034	Mg2+ binding site [ion binding]; other site
862967006035	G-X-G motif; other site
862967006036	rRNA large subunit methyltransferase; Provisional; Region: PRK00103
862967006037	Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365
862967006038	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
862967006039	protein binding site [polypeptide binding]; other site
862967006040	ParB/RepB/Spo0J family partition protein; Region: parB_part; TIGR00180
862967006041	ParB-like nuclease domain; Region: ParBc; pfam02195
862967006042	KorB domain; Region: KorB; pfam08535