-- dump date   	20140620_082827
-- class       	Genbank::misc_feature
-- table       	misc_feature_note
-- id	note
591365000001	chromosomal replication initiation protein; Reviewed; Region: dnaA; PRK00149
591365000002	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
591365000003	Walker A motif; other site
591365000004	ATP binding site [chemical binding]; other site
591365000005	Walker B motif; other site
591365000006	arginine finger; other site
591365000007	C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571
591365000008	DnaA box-binding interface [nucleotide binding]; other site
591365000009	DNA polymerase III subunit beta; Validated; Region: PRK05643
591365000010	Beta clamp domain.  The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria.  The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140
591365000011	putative DNA binding surface [nucleotide binding]; other site
591365000012	dimer interface [polypeptide binding]; other site
591365000013	beta-clamp/clamp loader binding surface; other site
591365000014	beta-clamp/translesion DNA polymerase binding surface; other site
591365000015	Protein of unknown function (DUF1307); Region: DUF1307; pfam06998
591365000016	GTP-binding protein YchF; Reviewed; Region: PRK09601
591365000017	YchF GTPase; Region: YchF; cd01900
591365000018	G1 box; other site
591365000019	GTP/Mg2+ binding site [chemical binding]; other site
591365000020	Switch I region; other site
591365000021	G2 box; other site
591365000022	Switch II region; other site
591365000023	G3 box; other site
591365000024	G4 box; other site
591365000025	G5 box; other site
591365000026	TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867
591365000027	Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462
591365000028	putative active site [active]
591365000029	catalytic residue [active]
591365000030	Transcription-repair coupling factor (superfamily II helicase) [DNA replication, recombination, and repair / Transcription]; Region: Mfd; COG1197
591365000031	CarD-like/TRCF domain; Region: CarD_TRCF; smart01058
591365000032	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
591365000033	ATP binding site [chemical binding]; other site
591365000034	putative Mg++ binding site [ion binding]; other site
591365000035	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
591365000036	nucleotide binding region [chemical binding]; other site
591365000037	ATP-binding site [chemical binding]; other site
591365000038	This domain is found in proteins necessary for strand-specific repair in DNA such as TRCF in Escherichia coli; Region: TRCF; smart00982
591365000039	Septum formation initiator [Cell division and chromosome partitioning]; Region: COG2919
591365000040	Beta-lactamase class A [Defense mechanisms]; Region: PenP; COG2367
591365000041	Beta-lactamase enzyme family; Region: Beta-lactamase2; pfam13354
591365000042	tRNA(Ile)-lysidine synthase MesJ [Cell cycle control, cell division, chromosome partitioning]; Region: MesJ; COG0037
591365000043	N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992
591365000044	Ligand Binding Site [chemical binding]; other site
591365000045	TilS substrate C-terminal domain; Region: TilS_C; smart00977
591365000046	Pyrimidine operon attenuation protein/uracil phosphoribosyltransferase [Nucleotide transport and metabolism]; Region: PyrR; COG2065
591365000047	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
591365000048	active site
591365000049	ATP-dependent Zn proteases [Posttranslational modification, protein turnover, chaperones]; Region: HflB; COG0465
591365000050	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
591365000051	Walker A motif; other site
591365000052	ATP binding site [chemical binding]; other site
591365000053	Walker B motif; other site
591365000054	arginine finger; other site
591365000055	Peptidase family M41; Region: Peptidase_M41; pfam01434
591365000056	Sialidase, N-terminal domain; Region: Sialidase; pfam02973
591365000057	Sialidases or neuraminidases function to bind and hydrolyze terminal sialic acid residues from various glycoconjugates as well as playing roles in pathogenesis, bacterial nutrition and cellular interactions. They have a six-bladed, beta-propeller fold...; Region: Sialidase; cd00260
591365000058	catalytic site [active]
591365000059	Sialidases or neuraminidases function to bind and hydrolyze terminal sialic acid residues from various glycoconjugates as well as playing roles in pathogenesis, bacterial nutrition and cellular interactions. They have a six-bladed, beta-propeller fold...; Region: Sialidase; cd00260
591365000060	Asp-box motif; other site
591365000061	Asp-box motif; other site
591365000062	catalytic site [active]
591365000063	rod shape-determining protein MreC; Provisional; Region: PRK13922
591365000064	rod shape-determining protein MreC; Region: MreC; pfam04085
591365000065	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3883
591365000066	Homeobox associated leucine zipper; Region: HALZ; cl02577
591365000067	Surface antigen [General function prediction only]; Region: COG3942
591365000068	CHAP domain; Region: CHAP; pfam05257
591365000069	ribose-phosphate pyrophosphokinase; Provisional; Region: PRK02269
591365000070	N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793
591365000071	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
591365000072	active site
591365000073	aromatic amino acid aminotransferase; Validated; Region: PRK07309
591365000074	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
591365000075	pyridoxal 5'-phosphate binding site [chemical binding]; other site
591365000076	homodimer interface [polypeptide binding]; other site
591365000077	catalytic residue [active]
591365000078	DNA repair protein RecO; Region: reco; TIGR00613
591365000079	Recombination protein O N terminal; Region: RecO_N; pfam11967
591365000080	Recombination protein O C terminal; Region: RecO_C; pfam02565
591365000081	putative phosphate acyltransferase; Provisional; Region: PRK05331
591365000082	phosphoribosylaminoimidazole-succinocarboxamide synthase; Reviewed; Region: PRK09362
591365000083	bacterial and archaeal 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_PurC; cd01415
591365000084	ATP binding site [chemical binding]; other site
591365000085	active site
591365000086	substrate binding site [chemical binding]; other site
591365000087	phosphoribosylformylglycinamidine synthase, clade II; Region: FGAM-synthase; TIGR01857
591365000088	AIR (aminoimidazole ribonucleotide) synthase related protein. This family includes Hydrogen expression/formation protein HypE, AIR synthases, FGAM (formylglycinamidine ribonucleotide) synthase and Selenophosphate synthetase (SelD). The N-terminal domain...; Region: PurM-like; cl10019
591365000089	PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203
591365000090	dimerization interface [polypeptide binding]; other site
591365000091	ATP binding site [chemical binding]; other site
591365000092	PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat2; cd02204
591365000093	dimerization interface [polypeptide binding]; other site
591365000094	ATP binding site [chemical binding]; other site
591365000095	Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740
591365000096	putative active site [active]
591365000097	catalytic triad [active]
591365000098	A new structural DNA glycosylase; Region: AlkD_like; cl11434
591365000099	HEAT repeats; Region: HEAT_2; pfam13646
591365000100	active site
591365000101	amidophosphoribosyltransferase; Provisional; Region: PRK07272
591365000102	Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of  glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715
591365000103	active site
591365000104	tetramer interface [polypeptide binding]; other site
591365000105	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
591365000106	active site
591365000107	phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385
591365000108	PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196
591365000109	dimerization interface [polypeptide binding]; other site
591365000110	putative ATP binding site [chemical binding]; other site
591365000111	phosphoribosylglycinamide formyltransferase; Reviewed; Region: purN; PRK05647
591365000112	Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645
591365000113	active site
591365000114	substrate binding site [chemical binding]; other site
591365000115	cosubstrate binding site; other site
591365000116	catalytic site [active]
591365000117	bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881
591365000118	Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal  ATIC formylase domain that formylates...; Region: IMPCH; cd01421
591365000119	purine monophosphate binding site [chemical binding]; other site
591365000120	dimer interface [polypeptide binding]; other site
591365000121	putative catalytic residues [active]
591365000122	AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; smart00798
591365000123	AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; cl03362
591365000124	GBS Bsp-like repeat; Region: GBS_Bsp-like; pfam08481
591365000125	GBS Bsp-like repeat; Region: GBS_Bsp-like; pfam08481
591365000126	GBS Bsp-like repeat; Region: GBS_Bsp-like; pfam08481
591365000127	GBS Bsp-like repeat; Region: GBS_Bsp-like; pfam08481
591365000128	GBS Bsp-like repeat; Region: GBS_Bsp-like; pfam08481
591365000129	Surface antigen [General function prediction only]; Region: COG3942
591365000130	CHAP domain; Region: CHAP; pfam05257
591365000131	Beta protein; Region: Beta_protein; pfam14350
591365000132	RES domain; Region: RES; pfam08808
591365000133	phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885
591365000134	Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844
591365000135	Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Region: GARS_A; pfam01071
591365000136	Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843
591365000137	ATP-grasp domain; Region: ATP-grasp_4; pfam13535
591365000138	Phosphoribosylcarboxyaminoimidazole (NCAIR) mutase [Nucleotide transport and metabolism]; Region: PurE; COG0041
591365000139	phosphoribosylaminoimidazole carboxylase ATPase subunit; Reviewed; Region: PRK06019
591365000140	ATP-grasp domain; Region: ATP-grasp; pfam02222
591365000141	Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; cl00518
591365000142	CAAX protease self-immunity; Region: Abi; pfam02517
591365000143	Superfamily I DNA and RNA helicases [General function prediction only]; Region: COG3972
591365000144	Family description; Region: UvrD_C_2; pfam13538
591365000145	adenylosuccinate lyase; Provisional; Region: PRK07492
591365000146	Adenylsuccinate lyase (ASL)_subgroup 1; Region: Adenylsuccinate_lyase_1; cd01360
591365000147	tetramer interface [polypeptide binding]; other site
591365000148	active site
591365000149	Adenylosuccinate lyase C-terminus; Region: ADSL_C; smart00998
591365000150	Transcriptional regulators [Transcription]; Region: PhnF; COG2188
591365000151	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
591365000152	DNA-binding site [nucleotide binding]; DNA binding site
591365000153	The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; Region: UTRA; smart00866
591365000154	Glycosyl hydrolases family 35; Region: Glyco_hydro_35; pfam01301
591365000155	PTS_IIB, PTS system, Mannose/sorbose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_man; cd00001
591365000156	active site
591365000157	phosphorylation site [posttranslational modification]
591365000158	Phosphotransferase system, mannose/fructose/N-acetylgalactosamine-specific component IIC [Carbohydrate transport and metabolism]; Region: ManY; COG3715
591365000159	PTS system mannose/fructose/sorbose family IID component; Region: EIID-AGA; pfam03613
591365000160	PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006
591365000161	active pocket/dimerization site; other site
591365000162	active site
591365000163	phosphorylation site [posttranslational modification]
591365000164	putative sugar isomerase, AgaS family; Region: agaS_fam; TIGR02815
591365000165	SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008
591365000166	dimer interface [polypeptide binding]; other site
591365000167	active site
591365000168	AgaS-like protein. AgaS contains a SIS (Sugar ISomerase) domain which is found in many phosphosugar isomerases and phosphosugar binding proteins. AgaS is a putative isomerase in Escherichia coli. It is similar to the glucosamine-6-phosphate synthases; Region: SIS_AgaS_like; cd05010
591365000169	putative active site [active]
591365000170	tagatose 1,6-diphosphate aldolase; Reviewed; Region: PRK04161
591365000171	galactose mutarotase_like; Region: galactose_mutarotase_like; cd09019
591365000172	active site
591365000173	catalytic residues [active]
591365000174	FOG: Glucan-binding domain (YG repeat) [General function prediction only]; Region: COG5263
591365000175	Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080
591365000176	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
591365000177	Walker A motif; other site
591365000178	ATP binding site [chemical binding]; other site
591365000179	Walker B motif; other site
591365000180	arginine finger; other site
591365000181	Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491
591365000182	Bacterial protein of unknown function (DUF925); Region: DUF925; pfam06042
591365000183	fimbrial isopeptide formation D2 domain; Region: RrgB_K2N_iso_D2; TIGR04226
591365000184	Domain of unknown function DUF11; Region: DUF11; cl17728
591365000185	fimbrial isopeptide formation D2 domain; Region: RrgB_K2N_iso_D2; TIGR04226
591365000186	Cna protein B-type domain; Region: Cna_B; pfam05738
591365000187	LPXTG-motif cell wall anchor domain; Region: LPXTG_anchor; TIGR01167
591365000188	Sortase C (SrtC) or subfamily-3 sortases are membrane cysteine transpeptidases found in Gram-positive bacteria that anchor surface proteins to peptidoglycans of the bacterial cell wall envelope. This involves a transpeptidation reaction in which the...; Region: Sortase_C_3; cd05827
591365000189	active site
591365000190	catalytic site [active]
591365000191	Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394
591365000192	Low molecular weight phosphatase family; Region: LMWPc; cd00115
591365000193	active site
591365000194	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4642
591365000195	Predicted acyltransferases [Lipid metabolism]; Region: COG1835
591365000196	SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053
591365000197	active site
591365000198	catalytic triad [active]
591365000199	oxyanion hole [active]
591365000200	bifunctional acetaldehyde-CoA/alcohol dehydrogenase; Provisional; Region: PRK13805
591365000201	Coenzyme A acylating aldehyde dehydrogenase (ACDH), ALDH family 20-like; Region: ALDH_F20_ACDH; cd07122
591365000202	putative catalytic cysteine [active]
591365000203	C-terminal alcohol dehydrogenase domain of the acetaldehyde dehydrogenase-alcohol dehydrogenase bifunctional two-domain protein (AAD); Region: AAD_C; cd08178
591365000204	putative active site [active]
591365000205	metal binding site [ion binding]; metal-binding site
591365000206	N-acetylmannosamine-6-phosphate epimerase (NanE) converts N-acetylmannosamine-6-phosphate to N-acetylglucosamine-6-phosphate. This reaction is part of the pathway that allows the usage of sialic acid as a carbohydrate source. Sialic acids are a family of...; Region: NanE; cd04729
591365000207	N-acetylmannosamine-6-phosphate 2-epimerase; Provisional; Region: PRK01130
591365000208	putative active site cavity [active]
591365000209	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
591365000210	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
591365000211	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
591365000212	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427
591365000213	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
591365000214	putative PBP binding loops; other site
591365000215	dimer interface [polypeptide binding]; other site
591365000216	ABC-ATPase subunit interface; other site
591365000217	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
591365000218	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
591365000219	dimer interface [polypeptide binding]; other site
591365000220	conserved gate region; other site
591365000221	putative PBP binding loops; other site
591365000222	ABC-ATPase subunit interface; other site
591365000223	Domain of unknown function (DUF386); Region: DUF386; cl01047
591365000224	Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329
591365000225	Class I aldolases; Region: Aldolase_Class_I; cl17187
591365000226	catalytic residue [active]
591365000227	Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940
591365000228	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012
591365000229	nucleotide binding site [chemical binding]; other site
591365000230	Transcriptional regulators [Transcription]; Region: RpiR; COG1737
591365000231	Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418
591365000232	RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013
591365000233	putative active site [active]
591365000234	Uncharacterized conserved protein [Function unknown]; Region: COG3589
591365000235	Bacterial protein of unknown function (DUF871); Region: DUF871; pfam05913
591365000236	PTS system, sucrose-specific IIBC component; Region: PTS-II-BC-sucr; TIGR01996
591365000237	PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212
591365000238	active site turn [active]
591365000239	phosphorylation site [posttranslational modification]
591365000240	Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263
591365000241	N-acetylmuramic acid-6-phosphate etherase; Reviewed; Region: murQ; PRK05441
591365000242	N-acetylmuramic acid 6-phosphate etherase. Members of this family contain the SIS (Sugar ISomerase) domain. The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. The bacterial cell wall sugar N-acetylmuramic acid...; Region: SIS_Etherase; cd05007
591365000243	putative active site [active]
591365000244	Transcriptional regulators [Transcription]; Region: RpiR; COG1737
591365000245	Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418
591365000246	RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013
591365000247	putative active site [active]
591365000248	V-type ATP synthase subunit I; Validated; Region: PRK05771
591365000249	V-type ATP synthase subunit K; Validated; Region: PRK06558
591365000250	ATP synthase subunit C; Region: ATP-synt_C; pfam00137
591365000251	ATP synthase subunit C; Region: ATP-synt_C; pfam00137
591365000252	Archaeal/vacuolar-type H+-ATPase subunit C [Energy production and conversion]; Region: NtpC; COG1527
591365000253	V-type ATP synthase subunit C; Provisional; Region: PRK01198; cl00660
591365000254	V-type ATP synthase subunit F; Provisional; Region: PRK01395
591365000255	V-type ATP synthase subunit A; Provisional; Region: PRK04192
591365000256	ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874
591365000257	V/A-type ATP synthase catalytic subunit A. These ATPases couple ATP hydrolysis to the build up of a H+ gradient, but V-type ATPases do not catalyze the reverse reaction.  The Vacuolar (V-type) ATPase is found in the membranes of vacuoles, the golgi...; Region: V_A-ATPase_A; cd01134
591365000258	Walker A motif/ATP binding site; other site
591365000259	Walker B motif; other site
591365000260	ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306
591365000261	V-type ATP synthase subunit B; Provisional; Region: PRK04196
591365000262	ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874
591365000263	V/A-type ATP synthase (non-catalytic) subunit B. These ATPases couple ATP hydrolysis to the build up of a H+ gradient, but V-type ATPases do not catalyze the reverse reaction. The Vacuolar (V-type) ATPase is found in the membranes of vacuoles, the golgi...; Region: V_A-ATPase_B; cd01135
591365000264	Walker A motif homologous position; other site
591365000265	Walker B motif; other site
591365000266	ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306
591365000267	V-type ATP synthase subunit D; Reviewed; Region: PRK00373
591365000268	Threonine synthase catalyzes the final step of threonine biosynthesis. The conversion of O-phosphohomoserine into threonine and inorganic phosphate is pyridoxal 5'-phosphate dependent. The Thr-synth_1 CD includes members from higher plants; Region: Thr-synth_2; cd01560
591365000269	Threonine synthase [Amino acid transport and metabolism]; Region: ThrC; COG0498
591365000270	pyridoxal 5'-phosphate binding site [chemical binding]; other site
591365000271	catalytic residue [active]
591365000272	Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534
591365000273	Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Thermotoga marina NorM; Region: MATE_NorM_like; cd13137
591365000274	Haloacid dehalogenase-like hydrolase; Region: HAD_2; pfam13419
591365000275	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
591365000276	motif II; other site
591365000277	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
591365000278	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
591365000279	Transcriptional regulator C-terminal region; Region: TetR_C_8; pfam14278
591365000280	Collagen binding domain; Region: Collagen_bind; pfam05737
591365000281	Cna protein B-type domain; Region: Cna_B; pfam05738
591365000282	streptococcal pilin isopeptide linkage domain; Region: strep_pil_rpt; TIGR03786
591365000283	T surface-antigen of pili; Region: FctA; pfam12892
591365000284	T surface-antigen of pili; Region: FctA; pfam12892
591365000285	streptococcal pilin isopeptide linkage domain; Region: strep_pil_rpt; TIGR03786
591365000286	T surface-antigen of pili; Region: FctA; pfam12892
591365000287	streptococcal pilin isopeptide linkage domain; Region: strep_pil_rpt; TIGR03786
591365000288	streptococcal pilin isopeptide linkage domain; Region: strep_pil_rpt; TIGR03786
591365000289	streptococcal pilin isopeptide linkage domain; Region: strep_pil_rpt; TIGR03786
591365000290	streptococcal pilin isopeptide linkage domain; Region: strep_pil_rpt; TIGR03786
591365000291	streptococcal pilin isopeptide linkage domain; Region: strep_pil_rpt; TIGR03786
591365000292	streptococcal pilin isopeptide linkage domain; Region: strep_pil_rpt; TIGR03786
591365000293	streptococcal pilin isopeptide linkage domain; Region: strep_pil_rpt; TIGR03786
591365000294	Thiol-activated cytolysin; Region: Thiol_cytolysin; pfam01289
591365000295	Winged helix DNA-binding domain; Region: HTH_27; pfam13463
591365000296	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
591365000297	ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235
591365000298	ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108
591365000299	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
591365000300	ABC-ATPase subunit  interface; other site
591365000301	dimer interface [polypeptide binding]; other site
591365000302	putative PBP binding regions; other site
591365000303	ABC-type metal ion transport system, periplasmic component/surface adhesin [Inorganic ion transport and metabolism]; Region: LraI; COG0803
591365000304	Metal binding protein AcdA.  These proteins have been shown to function in the ABC uptake of Zn2+ and Mn2+ and in competence for genetic transformation and adhesion. The AcdA proteins belong to the TroA superfamily of helical backbone metal receptor...; Region: AdcA; cd01017
591365000305	metal binding site [ion binding]; metal-binding site
591365000306	YodA lipocalin-like domain; Region: YodA; pfam09223
591365000307	copper transport repressor, CopY/TcrY family; Region: CopY_TcrY; TIGR02698
591365000308	Penicillinase repressor; Region: Pencillinase_R; pfam03965
591365000309	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217
591365000310	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371
591365000311	metal-binding site [ion binding]
591365000312	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
591365000313	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
591365000314	motif II; other site
591365000315	Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564
591365000316	Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869
591365000317	active site
591365000318	Transglycosylase; Region: Transgly; pfam00912
591365000319	penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074
591365000320	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760
591365000321	preprotein translocase subunit SecE; Reviewed; Region: secE; PRK07597
591365000322	transcription antitermination protein NusG; Validated; Region: nusG; PRK05609
591365000323	Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891
591365000324	putative homodimer interface [polypeptide binding]; other site
591365000325	NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091
591365000326	heterodimer interface [polypeptide binding]; other site
591365000327	homodimer interface [polypeptide binding]; other site
591365000328	Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425
591365000329	rRNA interaction site [nucleotide binding]; other site
591365000330	S8 interaction site; other site
591365000331	putative laminin-1 binding site; other site
591365000332	elongation factor Ts; Provisional; Region: tsf; PRK09377
591365000333	UBA/TS-N domain; Region: UBA; pfam00627
591365000334	Elongation factor TS; Region: EF_TS; pfam00889
591365000335	Elongation factor TS; Region: EF_TS; pfam00889
591365000336	Firmicute transcriptional repressor of class III stress genes (CtsR); Region: CtsR; pfam05848
591365000337	ATP-binding subunits of Clp protease and DnaK/DnaJ chaperones [Posttranslational modification, protein turnover, chaperones]; Region: clpA; COG0542
591365000338	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
591365000339	Walker A motif; other site
591365000340	ATP binding site [chemical binding]; other site
591365000341	Walker B motif; other site
591365000342	arginine finger; other site
591365000343	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
591365000344	Walker A motif; other site
591365000345	ATP binding site [chemical binding]; other site
591365000346	Walker B motif; other site
591365000347	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086
591365000348	putative acetyltransferase; Provisional; Region: PRK03624
591365000349	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
591365000350	Coenzyme A binding pocket [chemical binding]; other site
591365000351	putative TIM-barrel protein, nifR3 family; Region: nifR3_yhdG; TIGR00737
591365000352	Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801
591365000353	FMN binding site [chemical binding]; other site
591365000354	active site
591365000355	catalytic residues [active]
591365000356	substrate binding site [chemical binding]; other site
591365000357	Hsp33-like chaperonin; Reviewed; Region: hslO; PRK00114
591365000358	Heat shock protein 33 (Hsp33):  Cytosolic protein that acts as a molecular chaperone under oxidative conditions.  In normal (reducing) cytosolic conditions, four conserved Cys residues are coordinated by a Zn ion. Under oxidative stress (such as heat...; Region: Hsp33; cd00498
591365000359	dimerization interface [polypeptide binding]; other site
591365000360	domain crossover interface; other site
591365000361	redox-dependent activation switch; other site
591365000362	Uncharacterized protein involved in tellurite resistance [Inorganic ion transport and metabolism]; Region: TelA; COG3853
591365000363	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
591365000364	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
591365000365	non-specific DNA binding site [nucleotide binding]; other site
591365000366	salt bridge; other site
591365000367	sequence-specific DNA binding site [nucleotide binding]; other site
591365000368	transcriptional activator, Rgg/GadR/MutR family, C-terminal domain; Region: RGG_Cterm; TIGR01716
591365000369	Predicted Fe-S oxidoreductases [General function prediction only]; Region: COG0535
591365000370	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
591365000371	Domain of unknown function (DUF4008); Region: DUF4008; cl14869
591365000372	Predicted Fe-S oxidoreductases [General function prediction only]; Region: COG0535
591365000373	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
591365000374	FeS/SAM binding site; other site
591365000375	radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085
591365000376	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
591365000377	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
591365000378	Walker A/P-loop; other site
591365000379	ATP binding site [chemical binding]; other site
591365000380	Q-loop/lid; other site
591365000381	ABC transporter signature motif; other site
591365000382	Walker B; other site
591365000383	D-loop; other site
591365000384	H-loop/switch region; other site
591365000385	Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673
591365000386	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
591365000387	Coenzyme A binding pocket [chemical binding]; other site
591365000388	ATP-grasp domain; Region: ATP-grasp_4; cl17255
591365000389	Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788
591365000390	Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108
591365000391	GDP-binding site [chemical binding]; other site
591365000392	ACT binding site; other site
591365000393	IMP binding site; other site
591365000394	Restriction endonuclease; Region: Mrr_cat; pfam04471
591365000395	Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285
591365000396	nucleoside/Zn binding site; other site
591365000397	dimer interface [polypeptide binding]; other site
591365000398	catalytic motif [active]
591365000399	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
591365000400	non-specific DNA binding site [nucleotide binding]; other site
591365000401	salt bridge; other site
591365000402	sequence-specific DNA binding site [nucleotide binding]; other site
591365000403	transcriptional activator, Rgg/GadR/MutR family, C-terminal domain; Region: RGG_Cterm; TIGR01716
591365000404	AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207
591365000405	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
591365000406	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
591365000407	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
591365000408	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
591365000409	Walker A/P-loop; other site
591365000410	ATP binding site [chemical binding]; other site
591365000411	Q-loop/lid; other site
591365000412	ABC transporter signature motif; other site
591365000413	Walker B; other site
591365000414	D-loop; other site
591365000415	H-loop/switch region; other site
591365000416	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
591365000417	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
591365000418	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
591365000419	Walker A/P-loop; other site
591365000420	ATP binding site [chemical binding]; other site
591365000421	Q-loop/lid; other site
591365000422	ABC transporter signature motif; other site
591365000423	Walker B; other site
591365000424	D-loop; other site
591365000425	H-loop/switch region; other site
591365000426	Hypothetical bacterial integral membrane protein (Trep_Strep); Region: Trep_Strep; cl09823
591365000427	Cobalt transport protein; Region: CbiQ; cl00463
591365000428	ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122
591365000429	First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225
591365000430	Walker A/P-loop; other site
591365000431	ATP binding site [chemical binding]; other site
591365000432	Q-loop/lid; other site
591365000433	ABC transporter signature motif; other site
591365000434	Walker B; other site
591365000435	D-loop; other site
591365000436	H-loop/switch region; other site
591365000437	ABC transporter; Region: ABC_tran; pfam00005
591365000438	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
591365000439	Q-loop/lid; other site
591365000440	ABC transporter signature motif; other site
591365000441	Walker B; other site
591365000442	D-loop; other site
591365000443	H-loop/switch region; other site
591365000444	acylglycerophosphoethanolamine acyltransferase; Provisional; Region: PRK06814
591365000445	glucose-6-phosphate isomerase; Provisional; Region: pgi; PRK14097
591365000446	Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015
591365000447	active site
591365000448	dimer interface [polypeptide binding]; other site
591365000449	Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016
591365000450	dimer interface [polypeptide binding]; other site
591365000451	active site
591365000452	glycerol kinase; Provisional; Region: glpK; PRK00047
591365000453	Escherichia coli glycerol kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_EcGK_like; cd07786
591365000454	N- and C-terminal domain interface [polypeptide binding]; other site
591365000455	active site
591365000456	MgATP binding site [chemical binding]; other site
591365000457	catalytic site [active]
591365000458	metal binding site [ion binding]; metal-binding site
591365000459	glycerol binding site [chemical binding]; other site
591365000460	homotetramer interface [polypeptide binding]; other site
591365000461	homodimer interface [polypeptide binding]; other site
591365000462	FBP binding site [chemical binding]; other site
591365000463	protein IIAGlc interface [polypeptide binding]; other site
591365000464	ribonuclease P; Reviewed; Region: rnpA; PRK00499
591365000465	Preprotein translocase subunit YidC [Intracellular trafficking and secretion]; Region: YidC; COG0706
591365000466	membrane protein insertase, YidC/Oxa1 family, C-terminal domain; Region: yidC_oxa1_cterm; TIGR03592
591365000467	Predicted RNA-binding protein [General function prediction only]; Region: Jag; COG1847
591365000468	jag_K homology RNA-binding domain. The KH domain is found in proteins homologous to the Bacillus subtilis protein Jag, which is associated with SpoIIIJ and is necessary for the third stage of sporulation.  The KH motif is a beta-alpha-alpha-beta-beta...; Region: jag_KH; cd02414
591365000469	G-X-X-G motif; other site
591365000470	R3H domain found in proteins homologous to Bacillus subtilus Jag, which is associated with SpoIIIJ. SpoIIIJ is necessary for the third stage of sporulation. The name of the R3H domain comes from the characteristic spacing of the most conserved arginine...; Region: R3H_jag; cd02644
591365000471	RxxxH motif; other site
591365000472	50S ribosomal protein L34; Reviewed; Region: rpmH; PRK00399
591365000473	TatD like proteins;  E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310
591365000474	Predicted metal-dependent hydrolases with the TIM-barrel fold [General function prediction only]; Region: COG1099
591365000475	active site
591365000476	ribonuclease M5; Region: 5S_RNA_mat_M5; TIGR00334
591365000477	TOPRIM_ RNase M5_like: The topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain found in Ribonuclease M5: (RNase M5) and other small primase-like proteins from bacteria and archaea.  RNase M5 catalyzes the maturation of 5S rRNA in low...; Region: TOPRIM_RNase_M5_like; cd01027
591365000478	putative active site [active]
591365000479	putative metal binding site [ion binding]; other site
591365000480	Domain of unknown function (DUF4093); Region: DUF4093; pfam13331
591365000481	16S ribosomal RNA methyltransferase KsgA/Dim1 family protein; Reviewed; Region: ksgA; PRK00274
591365000482	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
591365000483	S-adenosylmethionine binding site [chemical binding]; other site
591365000484	GTPase RsgA; Reviewed; Region: PRK00098
591365000485	S1_YloQ_GTPase: YloQ GTase family (also known as YjeQ and CpgA), S1-like RNA-binding domain. Proteins in the YloQ GTase family bind the ribosome and have GTPase activity. The precise role of this family is unknown. The protein structure is composed of...; Region: S1_YloQ_GTPase; cd04466
591365000486	RNA binding site [nucleotide binding]; other site
591365000487	homodimer interface [polypeptide binding]; other site
591365000488	Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854
591365000489	GTPase/Zn-binding domain interface [polypeptide binding]; other site
591365000490	GTP/Mg2+ binding site [chemical binding]; other site
591365000491	G4 box; other site
591365000492	G5 box; other site
591365000493	G1 box; other site
591365000494	Switch I region; other site
591365000495	G2 box; other site
591365000496	G3 box; other site
591365000497	Switch II region; other site
591365000498	Pentose-5-phosphate-3-epimerase [Carbohydrate transport and metabolism]; Region: Rpe; COG0036
591365000499	Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429
591365000500	substrate binding site [chemical binding]; other site
591365000501	hexamer interface [polypeptide binding]; other site
591365000502	metal binding site [ion binding]; metal-binding site
591365000503	Thiamine pyrophosphokinase [Coenzyme metabolism]; Region: THI80; COG1564
591365000504	Thiamine pyrophosphokinase; Region: TPK; cd07995
591365000505	active site
591365000506	dimerization interface [polypeptide binding]; other site
591365000507	thiamine binding site [chemical binding]; other site
591365000508	Predicted nuclease of restriction endonuclease-like fold, RmuC family [General function prediction only]; Region: COG1322
591365000509	RmuC family; Region: RmuC; pfam02646
591365000510	Predicted HD-superfamily hydrolase [General function prediction only]; Region: COG3481
591365000511	YhaM_OBF_like: A subfamily of OB folds similar to that found in Bacillus subtilis YhaM and Staphylococcus aureus cmp-binding factor-1 (SaCBF1). Both these proteins are 3'-to-5'exoribonucleases. YhaM requires Mn2+ or Co2+ for activity and is...; Region: YhaM_OBF_like; cd04492
591365000512	generic binding surface II; other site
591365000513	generic binding surface I; other site
591365000514	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
591365000515	Zn2+ binding site [ion binding]; other site
591365000516	Mg2+ binding site [ion binding]; other site
591365000517	pur operon repressor; Provisional; Region: PRK09213
591365000518	Bacterial purine repressor, N-terminal; Region: PuR_N; pfam09182
591365000519	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
591365000520	active site
591365000521	S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368
591365000522	S17 interaction site [polypeptide binding]; other site
591365000523	S8 interaction site; other site
591365000524	16S rRNA interaction site [nucleotide binding]; other site
591365000525	streptomycin interaction site [chemical binding]; other site
591365000526	23S rRNA interaction site [nucleotide binding]; other site
591365000527	aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site
591365000528	30S ribosomal protein S7; Validated; Region: PRK05302
591365000529	elongation factor G; Reviewed; Region: PRK00007
591365000530	Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886
591365000531	G1 box; other site
591365000532	putative GEF interaction site [polypeptide binding]; other site
591365000533	GTP/Mg2+ binding site [chemical binding]; other site
591365000534	Switch I region; other site
591365000535	G2 box; other site
591365000536	G3 box; other site
591365000537	Switch II region; other site
591365000538	G4 box; other site
591365000539	G5 box; other site
591365000540	EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088
591365000541	EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434
591365000542	EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G.  Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713
591365000543	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
591365000544	gallidermin-class lantibiotic protection ABC transporter, ATP-binding subunit; Region: galliderm_ABC; TIGR03740
591365000545	Walker A/P-loop; other site
591365000546	ATP binding site [chemical binding]; other site
591365000547	Q-loop/lid; other site
591365000548	ABC transporter signature motif; other site
591365000549	Walker B; other site
591365000550	D-loop; other site
591365000551	H-loop/switch region; other site
591365000552	Glyceraldehyde-3-phosphate dehydrogenase/erythrose-4-phosphate dehydrogenase [Carbohydrate transport and metabolism]; Region: GapA; COG0057
591365000553	Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846
591365000554	Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800
591365000555	mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595
591365000556	Metallo-beta-lactamase superfamily; Region: Lactamase_B; pfam00753
591365000557	RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521
591365000558	hypothetical protein; Provisional; Region: PRK13667
591365000559	tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725
591365000560	Glycoprotease family; Region: Peptidase_M22; pfam00814
591365000561	ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575
591365000562	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
591365000563	Coenzyme A binding pocket [chemical binding]; other site
591365000564	UGMP family protein; Validated; Region: PRK09604
591365000565	tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725
591365000566	Carbamoyltransferase; Region: CmcH_NodU; pfam02543
591365000567	Predicted branched-chain amino acid permease (azaleucine resistance) [Amino acid transport and metabolism]; Region: AzlC; COG1296
591365000568	Predicted membrane protein [Function unknown]; Region: COG4392
591365000569	Methyltransferase domain; Region: Methyltransf_31; pfam13847
591365000570	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
591365000571	S-adenosylmethionine binding site [chemical binding]; other site
591365000572	Predicted transcriptional regulators [Transcription]; Region: COG1695
591365000573	Transcriptional regulator PadR-like family; Region: PadR; pfam03551
591365000574	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
591365000575	Major Facilitator Superfamily; Region: MFS_1; pfam07690
591365000576	putative substrate translocation pore; other site
591365000577	Predicted ATPase of the ABC class; Region: ABC_ATPase; pfam09818
591365000578	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
591365000579	Walker A/P-loop; other site
591365000580	ATP binding site [chemical binding]; other site
591365000581	Q-loop/lid; other site
591365000582	ABC transporter signature motif; other site
591365000583	Walker B; other site
591365000584	D-loop; other site
591365000585	H-loop/switch region; other site
591365000586	Helix-Turn-Helix DNA binding domain of the transcription regulators TipAL, Mta, and SkgA; Region: HTH_TipAL-Mta; cd01106
591365000587	MerR HTH family regulatory protein; Region: MerR_1; pfam13411
591365000588	DNA binding residues [nucleotide binding]
591365000589	dimer interface [polypeptide binding]; other site
591365000590	TipAS antibiotic-recognition domain; Region: TipAS; pfam07739
591365000591	MutT homolog-1 (MTH1) is a member of the Nudix hydrolase superfamily. MTH1, the mammalian counterpart of MutT, hydrolyzes oxidized purine nucleoside triphosphates, such as 8-oxo-dGTP and 2-hydroxy-ATP, to monophosphates, thereby preventing the...; Region: MTH1; cd03427
591365000592	putative active site [active]
591365000593	nucleotide binding site [chemical binding]; other site
591365000594	nudix motif; other site
591365000595	putative metal binding site [ion binding]; other site
591365000596	HI0933-like protein; Region: HI0933_like; pfam03486
591365000597	Chromate resistance exported protein; Region: Chrome_Resist; cl01744
591365000598	YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cl00630
591365000599	putative active site [active]
591365000600	Membrane domain of glycerophosphoryl diester phosphodiesterase; Region: GPDPase_memb; cl01974
591365000601	Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584
591365000602	Glycerophosphodiester phosphodiesterase domain of uncharacterized bacterial glycerophosphodiester phosphodiesterases; Region: GDPD_memb_like; cd08579
591365000603	putative active site [active]
591365000604	catalytic site [active]
591365000605	putative metal binding site [ion binding]; other site
591365000606	hypothetical protein; Validated; Region: PRK00153
591365000607	x-prolyl-dipeptidyl aminopeptidase; Provisional; Region: PRK05371
591365000608	X-Prolyl dipeptidyl aminopeptidase PepX, N-terminal; Region: PepX_N; pfam09168
591365000609	X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain; Region: PepX_C; pfam08530
591365000610	Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cd00333
591365000611	amphipathic channel; other site
591365000612	Asn-Pro-Ala signature motifs; other site
591365000613	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632
591365000614	Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680
591365000615	Beta-lactamase; Region: Beta-lactamase; pfam00144
591365000616	Mevalonate kinase [Lipid metabolism]; Region: ERG12; COG1577
591365000617	GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288
591365000618	diphosphomevalonate decarboxylase; Region: PLN02407
591365000619	diphosphomevalonate decarboxylase; Region: mevDPdecarb; TIGR01240
591365000620	Mevalonate kinase [Lipid metabolism]; Region: ERG12; COG1577
591365000621	GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544
591365000622	isopentenyl pyrophosphate isomerase; Provisional; Region: PRK05437
591365000623	Isopentenyl-diphosphate:dimethylallyl diphosphate isomerase type 2 (IDI-2) FMN-binding domain. Two types of IDIs have been characterized at present. The long known IDI-1 is only dependent on divalent metals for activity, whereas IDI-2 requires a metal; Region: IDI-2_FMN; cd02811
591365000624	homotetramer interface [polypeptide binding]; other site
591365000625	FMN binding site [chemical binding]; other site
591365000626	homodimer contacts [polypeptide binding]; other site
591365000627	putative active site [active]
591365000628	putative substrate binding site [chemical binding]; other site
591365000629	Class II hydroxymethylglutaryl-coenzyme A (HMG-CoA) reductase (HMGR); Region: HMG-CoA_reductase_classII; cd00644
591365000630	homodimer interface [polypeptide binding]; other site
591365000631	catalytic residues [active]
591365000632	NAD binding site [chemical binding]; other site
591365000633	substrate binding pocket [chemical binding]; other site
591365000634	flexible flap; other site
591365000635	"initiating" condensing enzymes are a subclass of decarboxylating condensing enzymes, including beta-ketoacyl [ACP] synthase, type III and polyketide synthases, type III, which include chalcone synthase and related enzymes. They are...; Region: init_cond_enzymes; cd00827
591365000636	3-hydroxy-3-methylglutaryl CoA synthase, prokaryotic clade; Region: HMG-CoA-S_prok; TIGR01835
591365000637	dimer interface [polypeptide binding]; other site
591365000638	active site
591365000639	Uncharacterized conserved protein [Function unknown]; Region: COG3610
591365000640	Uncharacterized conserved protein [Function unknown]; Region: COG2966
591365000641	Protein of unknown function (DUF1212); Region: DUF1212; pfam06738
591365000642	formate acetyltransferase 1; Region: pyr_form_ly_1; TIGR01255
591365000643	Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939
591365000644	DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586
591365000645	active site
591365000646	DNA polymerase IV; Validated; Region: PRK02406
591365000647	DNA binding site [nucleotide binding]
591365000648	helicase, putative, RecD/TraA family; Region: recD_rel; TIGR01448
591365000649	Ras GTPase Activating Domain; Region: RasGAP; cl02569
591365000650	AAA domain; Region: AAA_30; pfam13604
591365000651	Family description; Region: UvrD_C_2; pfam13538
591365000652	signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227
591365000653	The S24, S26 LexA/signal peptidase superfamily contains LexA-related and type I signal peptidase families. The S24 LexA protein domains include: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC 3.4.21.88), the...; Region: Peptidase_S24_S26; cd06462
591365000654	Catalytic site [active]
591365000655	The S24, S26 LexA/signal peptidase superfamily contains LexA-related and type I signal peptidase families. The S24 LexA protein domains include: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC 3.4.21.88), the...; Region: Peptidase_S24_S26; cl10465
591365000656	ribonuclease HIII; Provisional; Region: PRK00996
591365000657	Domain of unknown function (DUF3378); Region: DUF3378; pfam11858
591365000658	bacterial Ribonuclease HIII-like; Region: RNase_HII_bacteria_HIII_like; cd06590
591365000659	RNA/DNA hybrid binding site [nucleotide binding]; other site
591365000660	active site
591365000661	Uncharacterized membrane protein, required for colicin V production [General function prediction only]; Region: CvpA; COG1286
591365000662	Colicin V production protein; Region: Colicin_V; pfam02674
591365000663	recombination and DNA strand exchange inhibitor protein; Reviewed; Region: PRK00409
591365000664	MutS domain III; Region: MutS_III; pfam05192
591365000665	ATP-binding cassette domain of MutS2; Region: ABC_MutS2; cd03280
591365000666	Walker A/P-loop; other site
591365000667	ATP binding site [chemical binding]; other site
591365000668	Q-loop/lid; other site
591365000669	ABC transporter signature motif; other site
591365000670	Walker B; other site
591365000671	D-loop; other site
591365000672	H-loop/switch region; other site
591365000673	Smr domain; Region: Smr; pfam01713
591365000674	Peptidase family C69; Region: Peptidase_C69; pfam03577
591365000675	TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947
591365000676	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
591365000677	catalytic residues [active]
591365000678	Transcriptional regulator [Transcription]; Region: LysR; COG0583
591365000679	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
591365000680	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
591365000681	START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643
591365000682	hydrophobic ligand binding site; other site
591365000683	Amino acid permease; Region: AA_permease_2; pfam13520
591365000684	Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668
591365000685	Mechanosensitive ion channel; Region: MS_channel; pfam00924
591365000686	Predicted Zn-dependent protease (DUF2268); Region: DUF2268; pfam10026
591365000687	EXLDI protein; Region: EXLDI; TIGR04342
591365000688	glutamate dehydrogenase; Provisional; Region: PRK09414
591365000689	Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812
591365000690	NAD(P) binding domain of glutamate dehydrogenase, subgroup 2; Region: NAD_bind_2_Glu_DH; cd05313
591365000691	NAD(P) binding site [chemical binding]; other site
591365000692	dihydroorotate dehydrogenase (subfamily 1) family protein; Region: pyrD_sub1_fam; TIGR01037
591365000693	Dihydroorotate dehydrogenase (DHOD) class 1A FMN-binding domain. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine...; Region: DHOD_1A_like; cd04741
591365000694	active site
591365000695	FMN binding site [chemical binding]; other site
591365000696	substrate binding site [chemical binding]; other site
591365000697	catalytic residues [active]
591365000698	homodimer interface [polypeptide binding]; other site
591365000699	Peptide methionine sulfoxide reductase [Posttranslational modification, protein turnover, chaperones]; Region: MsrA; COG0225
591365000700	Conserved domain frequently associated with peptide methionine sulfoxide reductase [Posttranslational modification, protein turnover, chaperones]; Region: COG0229
591365000701	SelR domain; Region: SelR; pfam01641
591365000702	chlorohydrolase; Validated; Region: PRK06687
591365000703	TRZ/ATZ family contains enzymes from the atrazine degradation pathway and related hydrolases. Atrazine, a chlorinated herbizide, can be catabolized by a variety of different bacteria. The first three steps of the atrazine dehalogenation pathway are...; Region: ATZ_TRZ_like; cd01298
591365000704	active site
591365000705	putative substrate binding pocket [chemical binding]; other site
591365000706	Bacteriocin (Lactococcin_972); Region: Lactococcin_972; cl09891
591365000707	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4652
591365000708	Protein of unknown function (DUF1430); Region: DUF1430; pfam07242
591365000709	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
591365000710	putative bacteriocin export ABC transporter, lactococcin 972 group; Region: L_ocin_972_ABC; TIGR03608
591365000711	Walker A/P-loop; other site
591365000712	ATP binding site [chemical binding]; other site
591365000713	Q-loop/lid; other site
591365000714	ABC transporter signature motif; other site
591365000715	Walker B; other site
591365000716	D-loop; other site
591365000717	H-loop/switch region; other site
591365000718	helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cl17320
591365000719	non-specific DNA interactions [nucleotide binding]; other site
591365000720	DNA binding site [nucleotide binding]
591365000721	sequence specific DNA binding site [nucleotide binding]; other site
591365000722	putative cAMP binding site [chemical binding]; other site
591365000723	Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940
591365000724	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012
591365000725	nucleotide binding site [chemical binding]; other site
591365000726	Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455
591365000727	cellobiose phosphotransferase system IIC component; Reviewed; Region: celD; PRK09592
591365000728	TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186
591365000729	Carbohydrate binding domain; Region: CBM_4_9; pfam02018
591365000730	Laminarinase, member of the glycosyl hydrolase family 16; Region: GH16_laminarinase_like; cd08023
591365000731	active site
591365000732	catalytic residues [active]
591365000733	PTS_IIB_chitobiose_lichenan: subunit IIB of enzyme II (EII) of the N,N-diacetylchitobiose-specific and lichenan-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In these systems, EII is either a lichenan- or an N; Region: PTS_IIB_chitobiose_lichenan; cd05564
591365000734	active site
591365000735	P-loop; other site
591365000736	phosphorylation site [posttranslational modification]
591365000737	PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_lac; cd00215
591365000738	active site
591365000739	methionine cluster; other site
591365000740	phosphorylation site [posttranslational modification]
591365000741	metal binding site [ion binding]; metal-binding site
591365000742	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
591365000743	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
591365000744	Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Streptococcus aureus MepA; Region: MATE_MepA_like; cd13143
591365000745	Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534
591365000746	Protein of unknown function with HXXEE motif; Region: HXXEE; pfam13787
591365000747	AraC-like ligand binding domain; Region: AraC_binding; pfam02311
591365000748	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
591365000749	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
591365000750	Beta-glucosidase/6-phospho-beta-glucosidase/beta- galactosidase [Carbohydrate transport and metabolism]; Region: BglB; COG2723
591365000751	beta-galactosidase; Region: BGL; TIGR03356
591365000752	CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311
591365000753	substrate binding site [chemical binding]; other site
591365000754	THF binding site; other site
591365000755	zinc-binding site [ion binding]; other site
591365000756	hypothetical protein; Provisional; Region: PRK07329
591365000757	Polymerase and Histidinol Phosphatase domain; Region: PHP; cl17102
591365000758	active site
591365000759	GIY-YIG domain of uncharacterized hypothetical protein found in bacteria; Region: GIY-YIG_unchar_1; cd10446
591365000760	GIY-YIG motif/motif A; other site
591365000761	putative active site [active]
591365000762	putative metal binding site [ion binding]; other site
591365000763	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
591365000764	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
591365000765	Glycosyl hydrolase family 1; Region: Glyco_hydro_1; cl01046
591365000766	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
591365000767	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
591365000768	active site
591365000769	phosphorylation site [posttranslational modification]
591365000770	intermolecular recognition site; other site
591365000771	dimerization interface [polypeptide binding]; other site
591365000772	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
591365000773	DNA binding site [nucleotide binding]
591365000774	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
591365000775	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
591365000776	dimer interface [polypeptide binding]; other site
591365000777	phosphorylation site [posttranslational modification]
591365000778	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
591365000779	ATP binding site [chemical binding]; other site
591365000780	Mg2+ binding site [ion binding]; other site
591365000781	G-X-G motif; other site
591365000782	ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730
591365000783	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
591365000784	ATP-binding cassette domain of the bacitracin-resistance transporter; Region: ABC_BcrA_bacitracin_resist; cd03268
591365000785	Walker A/P-loop; other site
591365000786	ATP binding site [chemical binding]; other site
591365000787	Q-loop/lid; other site
591365000788	ABC transporter signature motif; other site
591365000789	Walker B; other site
591365000790	D-loop; other site
591365000791	H-loop/switch region; other site
591365000792	alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403
591365000793	Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333
591365000794	Ca binding site [ion binding]; other site
591365000795	active site
591365000796	catalytic site [active]
591365000797	Beta-galactosidase C-terminal domain; Region: Glyco_hydro_42C; pfam08533
591365000798	ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122
591365000799	First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225
591365000800	Walker A/P-loop; other site
591365000801	ATP binding site [chemical binding]; other site
591365000802	Q-loop/lid; other site
591365000803	ABC transporter signature motif; other site
591365000804	Walker B; other site
591365000805	D-loop; other site
591365000806	H-loop/switch region; other site
591365000807	ABC-type transport system involved in cytochrome c biogenesis, ATPase component [Posttranslational modification, protein turnover, chaperones]; Region: CcmA; COG4133
591365000808	First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225
591365000809	Walker A/P-loop; other site
591365000810	ATP binding site [chemical binding]; other site
591365000811	Q-loop/lid; other site
591365000812	ABC transporter signature motif; other site
591365000813	Walker B; other site
591365000814	D-loop; other site
591365000815	H-loop/switch region; other site
591365000816	ABC-type cobalt transport system, permease component; Region: ABC_cobalt; cl01943
591365000817	5-methyltetrahydropteroyltriglutamate--homocysteine S-methyltransferase; Provisional; Region: PRK05222
591365000818	CIMS - Cobalamine-independent methonine synthase, or MetE, N-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_N_terminal_like; cd03312
591365000819	THF binding site; other site
591365000820	CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311
591365000821	substrate binding site [chemical binding]; other site
591365000822	THF binding site; other site
591365000823	zinc-binding site [ion binding]; other site
591365000824	CDP-diacylglycerol pyrophosphatase; Region: CDH; cl00934
591365000825	TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947
591365000826	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
591365000827	catalytic residues [active]
591365000828	Dihaem cytochrome c; Region: DHC; pfam09626
591365000829	Predicted periplasmic protein (DUF2233); Region: DUF2233; pfam09992
591365000830	DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179
591365000831	Ligand binding site; other site
591365000832	Putative Catalytic site; other site
591365000833	DXD motif; other site
591365000834	Predicted membrane protein [Function unknown]; Region: COG2246
591365000835	GtrA-like protein; Region: GtrA; pfam04138
591365000836	WXG100 family type VII secretion target; Region: WXG100_ESAT6; TIGR03930
591365000837	type VII secretion protein EsaA, N-terminal domain; Region: T7_esaA_Nterm; TIGR03929
591365000838	YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061
591365000839	type VII secretion protein EssB; Region: T7_EssB; TIGR03926
591365000840	WXG100 protein secretion system (Wss), protein YukC; Region: YukC; cl01868
591365000841	DNA transporter; Region: FtsK_SpoIIIE_N; pfam12538
591365000842	type VII secretion protein EssC, C-terminal domain; Region: T7_EssCb_Firm; TIGR03928
591365000843	FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580
591365000844	FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580
591365000845	Domain of unknown function (DUF4176); Region: DUF4176; pfam13780
591365000846	30S ribosomal protein S6; Reviewed; Region: rpsF; PRK00453
591365000847	Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629
591365000848	SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496
591365000849	dimer interface [polypeptide binding]; other site
591365000850	ssDNA binding site [nucleotide binding]; other site
591365000851	tetramer (dimer of dimers) interface [polypeptide binding]; other site
591365000852	30S ribosomal protein S18; Reviewed; Region: rpsR; PRK00391
591365000853	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
591365000854	Coenzyme A binding pocket [chemical binding]; other site
591365000855	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
591365000856	Protein of unknown function (DUF1129); Region: DUF1129; cl11555
591365000857	Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598
591365000858	uncharacterized bacterial subfamily of the Escherichia coli CorA-Salmonella typhimurium ZntB family; Region: EcCorA_ZntB-like_u2; cd12827
591365000859	Cl binding site [ion binding]; other site
591365000860	oligomer interface [polypeptide binding]; other site
591365000861	excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349
591365000862	ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270
591365000863	ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270
591365000864	ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271
591365000865	Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006
591365000866	Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321
591365000867	Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092
591365000868	active site
591365000869	elongation factor P; Validated; Region: PRK00529
591365000870	Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207
591365000871	S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470
591365000872	RNA binding site [nucleotide binding]; other site
591365000873	S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794
591365000874	RNA binding site [nucleotide binding]; other site
591365000875	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1302
591365000876	transcription antitermination protein NusB; Reviewed; Region: nusB; PRK00202
591365000877	putative RNA binding site [nucleotide binding]; other site
591365000878	aspartate kinase; Reviewed; Region: PRK09034
591365000879	AAK_AKiii-YclM-BS: Amino Acid Kinase Superfamily (AAK), AKiii-YclM-BS; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the lysine plus threonine-sensitive aspartokinase isoenzyme AKIII, a monofunctional class enzyme found in...; Region: AAK_AKiii-YclM-BS; cd04245
591365000880	putative catalytic residues [active]
591365000881	putative nucleotide binding site [chemical binding]; other site
591365000882	putative aspartate binding site [chemical binding]; other site
591365000883	ACT domains located C-terminal to the catalytic domain of the lysine plus threonine-sensitive aspartokinase isoenzyme AKIII; Region: ACT_AKiii-YclM-BS_1; cd04911
591365000884	allosteric regulatory residue; other site
591365000885	ACT domains located C-terminal to the catalytic domain of the lysine plus threonine-sensitive aspartokinase isoenzyme AKIII; Region: ACT_AKiii-YclM-BS_2; cd04916
591365000886	enoyl-CoA hydratase; Provisional; Region: PRK07260
591365000887	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
591365000888	substrate binding site [chemical binding]; other site
591365000889	oxyanion hole (OAH) forming residues; other site
591365000890	trimer interface [polypeptide binding]; other site
591365000891	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
591365000892	MarR family; Region: MarR_2; pfam12802
591365000893	3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352
591365000894	Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830
591365000895	dimer interface [polypeptide binding]; other site
591365000896	active site
591365000897	CoA binding pocket [chemical binding]; other site
591365000898	putative enoyl-[acyl-carrier-protein] reductase II; Region: enACPred_II; TIGR03151
591365000899	2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730
591365000900	FMN binding site [chemical binding]; other site
591365000901	substrate binding site [chemical binding]; other site
591365000902	putative catalytic residue [active]
591365000903	(acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331
591365000904	malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128
591365000905	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557
591365000906	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
591365000907	NAD(P) binding site [chemical binding]; other site
591365000908	active site
591365000909	3-oxoacyl-(acyl carrier protein) synthase II; Reviewed; Region: PRK07314
591365000910	Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834
591365000911	dimer interface [polypeptide binding]; other site
591365000912	active site
591365000913	acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated; Region: PRK06302
591365000914	The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850
591365000915	carboxyltransferase (CT) interaction site; other site
591365000916	biotinylation site [posttranslational modification]; other site
591365000917	FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288
591365000918	acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591
591365000919	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
591365000920	Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786
591365000921	Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878
591365000922	acetyl-CoA carboxylase subunit beta; Validated; Region: PRK05654
591365000923	Uncharacterized protein family UPF0547; Region: UPF0547; pfam10571
591365000924	malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682
591365000925	acetyl-CoA carboxylase subunit alpha; Provisional; Region: PRK12319
591365000926	SNARE associated Golgi protein; Region: SNARE_assoc; cl00429
591365000927	Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586
591365000928	seryl-tRNA synthetase; Provisional; Region: PRK05431
591365000929	Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403
591365000930	Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770
591365000931	dimer interface [polypeptide binding]; other site
591365000932	active site
591365000933	motif 1; other site
591365000934	motif 2; other site
591365000935	motif 3; other site
591365000936	Domain of unknown function (DUF956); Region: DUF956; cl01917
591365000937	Phosphotransferase system, mannose/fructose/N-acetylgalactosamine-specific component IID [Carbohydrate transport and metabolism]; Region: ManZ; COG3716
591365000938	PTS system mannose-specific transporter subunit IIC; Provisional; Region: PRK15065
591365000939	PTS system mannose-specific transporter subunits IIAB; Provisional; Region: PRK15088
591365000940	PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006
591365000941	active pocket/dimerization site; other site
591365000942	active site
591365000943	phosphorylation site [posttranslational modification]
591365000944	PTS_IIB, PTS system, Mannose/sorbose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_man; cd00001
591365000945	active site
591365000946	phosphorylation site [posttranslational modification]
591365000947	ethanol-active dehydrogenase/acetaldehyde-active reductase; Provisional; Region: PRK09422
591365000948	Cinnamyl alcohol dehydrogenases (CAD); Region: CAD3; cd08297
591365000949	NAD binding site [chemical binding]; other site
591365000950	substrate binding site [chemical binding]; other site
591365000951	catalytic Zn binding site [ion binding]; other site
591365000952	tetramer interface [polypeptide binding]; other site
591365000953	structural Zn binding site [ion binding]; other site
591365000954	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
591365000955	haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282
591365000956	active site
591365000957	motif I; other site
591365000958	motif II; other site
591365000959	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cl17915
591365000960	Protein of unknown function (DUF1361); Region: DUF1361; pfam07099
591365000961	Xanthine/uracil/vitamin C permease [Nucleotide transport and    metabolism]; Region: COG2252
591365000962	Predicted ATPase or kinase [General function prediction only]; Region: COG0802
591365000963	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
591365000964	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
591365000965	Coenzyme A binding pocket [chemical binding]; other site
591365000966	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
591365000967	Transcriptional regulator [Transcription]; Region: LytR; COG1316
591365000968	HINT (histidine triad nucleotide-binding protein) subgroup: Members of this CD belong to the superfamily of histidine triad hydrolases that act on alpha-phosphate of ribonucleotides. This subgroup includes members from all three forms of cellular life; Region: HINT_subgroup; cd01277
591365000969	HIT family signature motif; other site
591365000970	catalytic residue [active]
591365000971	ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122
591365000972	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
591365000973	Walker A/P-loop; other site
591365000974	ATP binding site [chemical binding]; other site
591365000975	Q-loop/lid; other site
591365000976	ABC transporter signature motif; other site
591365000977	Walker B; other site
591365000978	D-loop; other site
591365000979	H-loop/switch region; other site
591365000980	Bacterial ABC transporter protein EcsB; Region: EcsB; pfam05975
591365000981	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
591365000982	S-adenosylmethionine binding site [chemical binding]; other site
591365000983	Nodulin-21 and CCC1-related protein family; Region: Nodulin-21_like_1; cd02432
591365000984	ribosome maturation protein RimP; Reviewed; Region: PRK00092
591365000985	Bacillus subtilis YxlS-like, C-terminal domain; Region: YlxS_C; cd01734
591365000986	putative oligomer interface [polypeptide binding]; other site
591365000987	putative RNA binding site [nucleotide binding]; other site
591365000988	transcription elongation factor NusA; Provisional; Region: nusA; PRK12327
591365000989	NusA N-terminal domain; Region: NusA_N; pfam08529
591365000990	S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455
591365000991	RNA binding site [nucleotide binding]; other site
591365000992	homodimer interface [polypeptide binding]; other site
591365000993	NusA-like KH domain; Region: KH_5; pfam13184
591365000994	NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134
591365000995	G-X-X-G motif; other site
591365000996	Ylxr homologs; group of conserved hypothetical bacterial proteins of unknown function; structure revealed putative RNA binding cleft; proteins are encoded by an operon that includes other proteins involved in transcription and/or translation; Region: YlxR; cd00279
591365000997	putative RNA binding cleft [nucleotide binding]; other site
591365000998	hypothetical protein; Provisional; Region: PRK07283
591365000999	Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760
591365001000	translation initiation factor IF-2; Validated; Region: infB; PRK05306
591365001001	Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760
591365001002	Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887
591365001003	G1 box; other site
591365001004	putative GEF interaction site [polypeptide binding]; other site
591365001005	GTP/Mg2+ binding site [chemical binding]; other site
591365001006	Switch I region; other site
591365001007	G2 box; other site
591365001008	G3 box; other site
591365001009	Switch II region; other site
591365001010	G4 box; other site
591365001011	G5 box; other site
591365001012	This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702
591365001013	Translation-initiation factor 2; Region: IF-2; pfam11987
591365001014	mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692
591365001015	ribosome-binding factor A; Validated; Region: rbfA; PRK00521
591365001016	Na+/phosphate symporter [Inorganic ion transport and metabolism]; Region: NptA; COG1283
591365001017	Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690
591365001018	Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690
591365001019	PhoU domain; Region: PhoU; pfam01895
591365001020	PhoU domain; Region: PhoU; pfam01895
591365001021	N-acetylglucosamine-6-phosphate deacetylase [Carbohydrate transport and metabolism]; Region: NagA; COG1820
591365001022	N-acetylglucosamine-6-phosphate deacetylase, NagA, catalyzes the hydrolysis of the N-acetyl group of N-acetyl-glucosamine-6-phosphate (GlcNAc-6-P) to glucosamine 6-phosphate and acetate. This is the first committed step in the biosynthetic pathway to...; Region: NagA; cd00854
591365001023	active site
591365001024	dimer interface [polypeptide binding]; other site
591365001025	Gram-positive signal peptide, YSIRK family; Region: YSIRK_signal; TIGR01168
591365001026	Peptidase S8 family domain in Streptococcal C5a peptidases; Region: Peptidases_S8_C5a_Peptidase; cd07475
591365001027	putative active site [active]
591365001028	catalytic triad [active]
591365001029	PA_C5a_like: Protease-associated domain containing proteins like Streptococcus pyogenes C5a peptidase. This group contains various PA domain-containing proteins similar to S. pyogenes C5a, including, i) Vpr, a minor extracellular serine protease from...; Region: PA_C5a_like; cd02133
591365001030	PA/protease domain interface [polypeptide binding]; other site
591365001031	putative integrin binding motif; other site
591365001032	Peptidase S8 family domain in Streptococcal C5a peptidases; Region: Peptidases_S8_C5a_Peptidase; cd07475
591365001033	Fn3-like domain (DUF1034); Region: DUF1034; pfam06280
591365001034	C-terminal domain of CHU protein family; Region: CHU_C; cl17875
591365001035	Ligand-binding SRPBCC domain of Streptococcus mutans Smu.440 and related proteins; Region: SRPBCC_Smu440-like; cd08862
591365001036	putative hydrophobic ligand binding site [chemical binding]; other site
591365001037	Transcriptional regulators [Transcription]; Region: MarR; COG1846
591365001038	MarR family; Region: MarR_2; cl17246
591365001039	hypothetical protein; Provisional; Region: PRK02268
591365001040	Class II Glycyl-tRNA synthetase (GlyRS) alpha subunit core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes and in arabidopsis. It is responsible for the...; Region: GlyRS_alpha_core; cd00733
591365001041	dimer interface [polypeptide binding]; other site
591365001042	motif 1; other site
591365001043	active site
591365001044	motif 2; other site
591365001045	motif 3; other site
591365001046	glycyl-tRNA synthetase subunit beta; Validated; Region: glyS; PRK01233
591365001047	Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020
591365001048	K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569
591365001049	TrkA-N domain; Region: TrkA_N; pfam02254
591365001050	TrkA-C domain; Region: TrkA_C; pfam02080
591365001051	Trk-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: TrkG; COG0168
591365001052	potassium uptake protein, TrkH family; Region: 2a38; TIGR00933
591365001053	Predicted S-adenosylmethionine-dependent methyltransferase involved in cell envelope biogenesis [Cell envelope biogenesis, outer membrane]; Region: COG0275
591365001054	MraW methylase family; Region: Methyltransf_5; pfam01795
591365001055	Protein required for the initiation of cell division [Cell division and chromosome partitioning]; Region: FtsL; COG4839
591365001056	Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768
591365001057	Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717
591365001058	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905
591365001059	PASTA domain of PBP2x-like proteins, first repeat. Penicillin-binding proteins (PBPs) are the major targets for beta-lactam antibiotics, like penicillins and cephalosporins. Beta-lactam antibiotics specifically inhibit transpeptidase activity by...; Region: PASTA_Pbp2x-like_1; cd06576
591365001060	PASTA domain of PBP2x-like proteins, second repeat. Penicillin-binding proteins (PBPs) are the major targets for beta-lactam antibiotics, like penicillins and cephalosporins. Beta-lactam antibiotics specifically inhibit transpeptidase activity by...; Region: PASTA_Pbp2x-like_2; cd06575
591365001061	phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108
591365001062	Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852
591365001063	Mg++ binding site [ion binding]; other site
591365001064	putative catalytic motif [active]
591365001065	putative substrate binding site [chemical binding]; other site
591365001066	ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166
591365001067	The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504
591365001068	peptide binding site [polypeptide binding]; other site
591365001069	Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746
591365001070	active site
591365001071	catalytic triad [active]
591365001072	putative oxyanion hole; other site
591365001073	GyrI-like small molecule binding domain; Region: GyrI-like; cl01368
591365001074	fructose-bisphosphate aldolase; Provisional; Region: PRK09197
591365001075	Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947
591365001076	intersubunit interface [polypeptide binding]; other site
591365001077	active site
591365001078	zinc binding site [ion binding]; other site
591365001079	Na+ binding site [ion binding]; other site
591365001080	LytTr DNA-binding domain; Region: LytTR; smart00850
591365001081	Cell wall-active antibiotics response protein (DUF2154); Region: DUF2154; pfam09922
591365001082	50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359
591365001083	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1302
591365001084	DAK2 domain fusion protein YloV; Region: YloV; TIGR03599
591365001085	DAK2 domain; Region: Dak2; pfam02734
591365001086	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
591365001087	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
591365001088	Walker A/P-loop; other site
591365001089	ATP binding site [chemical binding]; other site
591365001090	Q-loop/lid; other site
591365001091	ABC transporter signature motif; other site
591365001092	Walker B; other site
591365001093	D-loop; other site
591365001094	H-loop/switch region; other site
591365001095	ABC-2 type transporter; Region: ABC2_membrane; pfam01061
591365001096	ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842
591365001097	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585
591365001098	Histidine kinase; Region: HisKA_3; pfam07730
591365001099	Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518
591365001100	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
591365001101	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
591365001102	active site
591365001103	phosphorylation site [posttranslational modification]
591365001104	intermolecular recognition site; other site
591365001105	dimerization interface [polypeptide binding]; other site
591365001106	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
591365001107	DNA binding residues [nucleotide binding]
591365001108	dimerization interface [polypeptide binding]; other site
591365001109	A subgroup of the band 7 domain of flotillin (reggie) like proteins. This subgroup contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin.  Many of these band 7 domain-containing proteins are lipid raft-associated.  Individual...; Region: Band_7_4; cd03407
591365001110	HflK protein; Region: hflK; TIGR01933
591365001111	ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126
591365001112	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
591365001113	Walker A/P-loop; other site
591365001114	ATP binding site [chemical binding]; other site
591365001115	Q-loop/lid; other site
591365001116	ABC transporter signature motif; other site
591365001117	Walker B; other site
591365001118	D-loop; other site
591365001119	H-loop/switch region; other site
591365001120	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
591365001121	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
591365001122	substrate binding pocket [chemical binding]; other site
591365001123	membrane-bound complex binding site; other site
591365001124	hinge residues; other site
591365001125	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
591365001126	dimer interface [polypeptide binding]; other site
591365001127	conserved gate region; other site
591365001128	putative PBP binding loops; other site
591365001129	ABC-ATPase subunit interface; other site
591365001130	Predicted membrane protein (DUF2207); Region: DUF2207; pfam09972
591365001131	undecaprenyl pyrophosphate phosphatase; Reviewed; Region: PRK00281
591365001132	adaptor protein; Provisional; Region: PRK02315
591365001133	UDP-N-acetylmuramyl pentapeptide phosphotransferase/UDP-N- acetylglucosamine-1-phosphate transferase [Cell envelope biogenesis, outer membrane]; Region: Rfe; COG0472
591365001134	This subfamily contains Escherichia coli WecA, Bacillus subtilis TagO and related proteins. WecA is an UDP-N-acetylglucosamine (GlcNAc):undecaprenyl-phosphate (Und-P) GlcNAc-1-phosphate transferase that catalyzes the formation of a phosphodiester bond...; Region: GT_WecA_like; cd06853
591365001135	Mg++ binding site [ion binding]; other site
591365001136	putative catalytic motif [active]
591365001137	Cysteine desulfurase activator ATPase [Posttranslational modification, protein turnover, chaperones]; Region: sufC; COG0396
591365001138	ABC-type transport system involved in Fe-S cluster assembly, ATPase component; Region: ABC_FeS_Assembly; cd03217
591365001139	Walker A/P-loop; other site
591365001140	ATP binding site [chemical binding]; other site
591365001141	Q-loop/lid; other site
591365001142	ABC transporter signature motif; other site
591365001143	Walker B; other site
591365001144	D-loop; other site
591365001145	H-loop/switch region; other site
591365001146	Cysteine desulfurase activator SufB [Posttranslational modification, protein turnover, chaperones]; Region: SufB; COG0719
591365001147	FeS assembly protein SufD; Region: sufD; TIGR01981
591365001148	Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520
591365001149	Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453
591365001150	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
591365001151	catalytic residue [active]
591365001152	NifU homolog involved in Fe-S cluster formation [Energy production and conversion]; Region: IscU; COG0822
591365001153	Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664
591365001154	trimerization site [polypeptide binding]; other site
591365001155	active site
591365001156	D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: DacC; COG1686
591365001157	Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872
591365001158	Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; smart00936
591365001159	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251
591365001160	DEAD-like helicases superfamily; Region: DEXDc; smart00487
591365001161	ATP binding site [chemical binding]; other site
591365001162	putative Mg++ binding site [ion binding]; other site
591365001163	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
591365001164	nucleotide binding region [chemical binding]; other site
591365001165	ATP-binding site [chemical binding]; other site
591365001166	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
591365001167	dimer interface [polypeptide binding]; other site
591365001168	conserved gate region; other site
591365001169	putative PBP binding loops; other site
591365001170	ABC-ATPase subunit interface; other site
591365001171	ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126
591365001172	ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262
591365001173	Walker A/P-loop; other site
591365001174	ATP binding site [chemical binding]; other site
591365001175	Q-loop/lid; other site
591365001176	ABC transporter signature motif; other site
591365001177	Walker B; other site
591365001178	D-loop; other site
591365001179	H-loop/switch region; other site
591365001180	thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292
591365001181	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
591365001182	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
591365001183	Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113
591365001184	nicotinate phosphoribosyltransferase; Validated; Region: PRK09243
591365001185	Nicotinate phosphoribosyltransferase (NAPRTase), subgroup A. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting, reaction...; Region: NAPRTase_A; cd01570
591365001186	active site
591365001187	NAD synthase [Coenzyme metabolism]; Region: NadE; COG0171
591365001188	NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553
591365001189	homodimer interface [polypeptide binding]; other site
591365001190	NAD binding pocket [chemical binding]; other site
591365001191	ATP binding pocket [chemical binding]; other site
591365001192	Mg binding site [ion binding]; other site
591365001193	active-site loop [active]
591365001194	Peptidase C1B subfamily (MEROPS database nomenclature); composed of eukaryotic bleomycin hydrolases (BH) and bacterial aminopeptidases C (pepC). The proteins of this subfamily contain a large insert relative to the C1A peptidase (papain) subfamily. BH is...; Region: Peptidase_C1B; cd00585
591365001195	trimer interface [polypeptide binding]; other site
591365001196	active site
591365001197	G bulge; other site
591365001198	Transglycosylase; Region: Transgly; pfam00912
591365001199	penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074
591365001200	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760
591365001201	Holliday junction-specific endonuclease; Reviewed; Region: recU; PRK02234
591365001202	hypothetical protein; Provisional; Region: PRK13660
591365001203	cell division protein GpsB; Provisional; Region: PRK14127
591365001204	DivIVA domain; Region: DivI1A_domain; TIGR03544
591365001205	Predicted N6-adenine-specific DNA methylase [DNA replication, recombination, and repair]; Region: COG0116
591365001206	THUMP domain associated with S-adenosylmethionine-dependent methyltransferases; Region: THUMP_AdoMetMT; cd11715
591365001207	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173
591365001208	peroxiredoxin; Region: AhpC; TIGR03137
591365001209	Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015
591365001210	dimer interface [polypeptide binding]; other site
591365001211	decamer (pentamer of dimers) interface [polypeptide binding]; other site
591365001212	catalytic triad [active]
591365001213	peroxidatic and resolving cysteines [active]
591365001214	alkyl hydroperoxide reductase subunit F; Provisional; Region: PRK15317
591365001215	Alkyl hydroperoxide reductase F subunit (AhpF) N-terminal domain (NTD) family, N-terminal TRX-fold subdomain; AhpF is a homodimeric flavoenzyme which catalyzes the NADH-dependent reduction of the peroxiredoxin AhpC, which in turn catalyzes the reduction...; Region: AhpF_NTD_N; cd02974
591365001216	catalytic residue [active]
591365001217	TRX-GRX-like family, Alkyl hydroperoxide reductase F subunit (AhpF) N-terminal domain (NTD) subfamily, C-terminal TRX-fold subdomain; AhpF is a homodimeric flavoenzyme which catalyzes the NADH-dependent reduction of the peroxiredoxin AhpC, which then...; Region: AhpF_NTD_C; cd03026
591365001218	catalytic residues [active]
591365001219	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
591365001220	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
591365001221	S-ribosylhomocysteinase; Provisional; Region: PRK02260
591365001222	hypothetical protein; Provisional; Region: PRK00106
591365001223	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
591365001224	Zn2+ binding site [ion binding]; other site
591365001225	Mg2+ binding site [ion binding]; other site
591365001226	Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194
591365001227	Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071
591365001228	catalytic site [active]
591365001229	G-X2-G-X-G-K; other site
591365001230	DNA-directed RNA polymerase subunit omega; Reviewed; Region: rpoZ; PRK00392
591365001231	Primosomal protein N' (replication factor Y) - superfamily II helicase [DNA replication, recombination, and repair]; Region: PriA; COG1198
591365001232	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
591365001233	ATP binding site [chemical binding]; other site
591365001234	putative Mg++ binding site [ion binding]; other site
591365001235	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
591365001236	ATP-binding site [chemical binding]; other site
591365001237	methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005
591365001238	Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646
591365001239	putative active site [active]
591365001240	substrate binding site [chemical binding]; other site
591365001241	putative cosubstrate binding site; other site
591365001242	catalytic site [active]
591365001243	C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704
591365001244	substrate binding site [chemical binding]; other site
591365001245	16S rRNA methyltransferase B; Provisional; Region: PRK14902
591365001246	NusB family; Region: NusB; pfam01029
591365001247	putative RNA binding site [nucleotide binding]; other site
591365001248	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
591365001249	S-adenosylmethionine binding site [chemical binding]; other site
591365001250	Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143
591365001251	active site
591365001252	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
591365001253	Catalytic domain of Protein Kinases; Region: PKc; cd00180
591365001254	active site
591365001255	ATP binding site [chemical binding]; other site
591365001256	substrate binding site [chemical binding]; other site
591365001257	activation loop (A-loop); other site
591365001258	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2815
591365001259	PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577
591365001260	PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577
591365001261	PASTA domain. This domain is found at the C-termini of several Penicillin-binding proteins (PBPs) and bacterial serine/threonine kinases. It is a small globular fold consisting of 3 beta-sheets and an alpha-helix. The name PASTA is derived from PBP and...; Region: PASTA; cl02768
591365001262	Predicted membrane protein [Function unknown]; Region: COG4758
591365001263	Cell wall-active antibiotics response protein (DUF2154); Region: DUF2154; pfam09922
591365001264	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
591365001265	Histidine kinase; Region: HisKA_3; pfam07730
591365001266	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
591365001267	ATP binding site [chemical binding]; other site
591365001268	Mg2+ binding site [ion binding]; other site
591365001269	G-X-G motif; other site
591365001270	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
591365001271	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
591365001272	active site
591365001273	phosphorylation site [posttranslational modification]
591365001274	intermolecular recognition site; other site
591365001275	dimerization interface [polypeptide binding]; other site
591365001276	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
591365001277	DNA binding residues [nucleotide binding]
591365001278	dimerization interface [polypeptide binding]; other site
591365001279	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
591365001280	haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282
591365001281	active site
591365001282	motif I; other site
591365001283	motif II; other site
591365001284	haloacid dehalogenase-like hydrolase; Region: HAD; cl17202
591365001285	cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317
591365001286	active site
591365001287	Predicted RNA binding protein (contains ribosomal protein S1 domain) [Translation, ribosomal structure and biogenesis]; Region: VacB; COG1098
591365001288	hypothetical protein; Provisional; Region: PRK07252
591365001289	RNA binding site [nucleotide binding]; other site
591365001290	Staphylococcal protein of unknown function (DUF960); Region: DUF960; pfam06124
591365001291	hypothetical protein; Provisional; Region: PRK13662
591365001292	recombination regulator RecX; Provisional; Region: recX; PRK14135
591365001293	Phosphotransferase enzyme family; Region: APH; pfam01636
591365001294	Aminoglycoside 3'-phosphotransferase (APH). The APH subfamily is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs), RIO kinases, actin-fragmin...; Region: APH; cd05150
591365001295	active site
591365001296	ATP binding site [chemical binding]; other site
591365001297	antibiotic binding site [chemical binding]; other site
591365001298	TRAM domain; Region: TRAM; cl01282
591365001299	SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase [Translation, ribosomal structure and biogenesis]; Region: TrmA; COG2265
591365001300	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
591365001301	S-adenosylmethionine binding site [chemical binding]; other site
591365001302	Uncharacterized conserved protein [Function unknown]; Region: COG2461
591365001303	Family of unknown function (DUF438); Region: DUF438; pfam04282
591365001304	Hemerythrin HHE cation binding domain; Region: Hemerythrin; pfam01814
591365001305	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5255
591365001306	LigT like Phosphoesterase; Region: LigT_PEase; pfam02834
591365001307	Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670
591365001308	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
591365001309	Coenzyme A binding pocket [chemical binding]; other site
591365001310	valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729
591365001311	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
591365001312	active site
591365001313	HIGH motif; other site
591365001314	nucleotide binding site [chemical binding]; other site
591365001315	Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603
591365001316	catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817
591365001317	active site
591365001318	KMSKS motif; other site
591365001319	Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962
591365001320	tRNA binding surface [nucleotide binding]; other site
591365001321	anticodon binding site; other site
591365001322	Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458
591365001323	Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031
591365001324	CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561
591365001325	dimer interface [polypeptide binding]; other site
591365001326	pyridoxal 5'-phosphate binding site [chemical binding]; other site
591365001327	catalytic residue [active]
591365001328	Uncharacterized conserved protein [Function unknown]; Region: COG1739
591365001329	Uncharacterized protein family UPF0029; Region: UPF0029; pfam01205
591365001330	Domain of unknown function (DUF1949); Region: DUF1949; pfam09186
591365001331	Superfamily II DNA/RNA helicase required for DNA uptake (late competence protein) [DNA replication, recombination, and repair]; Region: comFA; COG4098
591365001332	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
591365001333	ATP binding site [chemical binding]; other site
591365001334	putative Mg++ binding site [ion binding]; other site
591365001335	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
591365001336	nucleotide binding region [chemical binding]; other site
591365001337	ATP-binding site [chemical binding]; other site
591365001338	Predicted amidophosphoribosyltransferases [General function prediction only]; Region: ComFC; COG1040
591365001339	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
591365001340	active site
591365001341	RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY,  is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552
591365001342	30S subunit binding site; other site
591365001343	Conserved hypothetical protein 95; Region: Cons_hypoth95; pfam03602
591365001344	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
591365001345	S-adenosylmethionine binding site [chemical binding]; other site
591365001346	phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168
591365001347	Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163
591365001348	active site
591365001349	(T/H)XGH motif; other site
591365001350	Predicted secreted protein containing a PDZ domain [Signal transduction mechanisms]; Region: SdrC; COG3480
591365001351	PDZ domain, also called DHR (Dlg homologous region) or GLGF (after a conserved sequence motif). Many PDZ domains bind C-terminal polypeptides, though binding to internal (non-C-terminal) polypeptides and even to lipids has been demonstrated; Region: PDZ; cl00117
591365001352	protein binding site [polypeptide binding]; other site
591365001353	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4470
591365001354	ribosomal RNA large subunit methyltransferase N; Provisional; Region: PRK14455
591365001355	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
591365001356	FeS/SAM binding site; other site
591365001357	VanZ like family; Region: VanZ; pfam04892
591365001358	Type II secretory pathway, prepilin signal peptidase PulO and related peptidases [Cell motility and secretion / Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: PulO; COG1989
591365001359	Bacterial Peptidase A24 N-terminal domain; Region: DiS_P_DiS; pfam06750
591365001360	DNA-binding ferritin-like protein (oxidative damage protectant) [Inorganic ion transport and metabolism]; Region: Dps; COG0783
591365001361	DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043
591365001362	dimerization interface [polypeptide binding]; other site
591365001363	DPS ferroxidase diiron center [ion binding]; other site
591365001364	ion pore; other site
591365001365	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158
591365001366	active site residue [active]
591365001367	16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187
591365001368	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
591365001369	RNA binding surface [nucleotide binding]; other site
591365001370	Pseudouridine synthase, Escherichia coli RsuA like; Region: PseudoU_synth_RsuA; cd02553
591365001371	active site
591365001372	uracil binding [chemical binding]; other site
591365001373	Predicted membrane GTPase involved in stress response [Signal transduction mechanisms]; Region: TypA; COG1217
591365001374	Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891
591365001375	G1 box; other site
591365001376	putative GEF interaction site [polypeptide binding]; other site
591365001377	GTP/Mg2+ binding site [chemical binding]; other site
591365001378	Switch I region; other site
591365001379	G2 box; other site
591365001380	G3 box; other site
591365001381	Switch II region; other site
591365001382	G4 box; other site
591365001383	G5 box; other site
591365001384	BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu.  BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691
591365001385	BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants.  BipA is a highly...; Region: BipA_TypA_C; cd03710
591365001386	Protein of unknown function (DUF3165); Region: DUF3165; pfam11364
591365001387	UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK02472
591365001388	Alanine dehydrogenase/PNT, C-terminal domain; Region: AlaDh_PNT_C; smart01002
591365001389	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
591365001390	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
591365001391	undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726
591365001392	MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785
591365001393	active site
591365001394	homodimer interface [polypeptide binding]; other site
591365001395	Cell division septal protein [Cell envelope biogenesis, outer membrane]; Region: FtsQ; COG1589
591365001396	POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478
591365001397	Cell division protein FtsQ; Region: FtsQ; pfam03799
591365001398	Cell division ATPase FtsA [Cell division and chromosome partitioning]; Region: ftsA; COG0849
591365001399	Cell division protein FtsA; Region: FtsA; smart00842
591365001400	Cell division protein FtsA; Region: FtsA; pfam14450
591365001401	Domain of unknown function (DUF3484); Region: DUF3484; pfam11983
591365001402	cell division protein FtsZ; Validated; Region: PRK09330
591365001403	FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes.  FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201
591365001404	nucleotide binding site [chemical binding]; other site
591365001405	SulA interaction site; other site
591365001406	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, YBL036c-like proteins; Region: PLPDE_III_YBL036c_like; cd00635
591365001407	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
591365001408	catalytic residue [active]
591365001409	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1799
591365001410	Uncharacterized conserved protein, contains S4-like domain [Function unknown]; Region: COG2302
591365001411	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cl09940
591365001412	DivIVA protein; Region: DivIVA; pfam05103
591365001413	DivIVA domain; Region: DivI1A_domain; TIGR03544
591365001414	isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK05743
591365001415	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
591365001416	active site
591365001417	HIGH motif; other site
591365001418	nucleotide binding site [chemical binding]; other site
591365001419	catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818
591365001420	active site
591365001421	KMSKS motif; other site
591365001422	Anticodon-binding domain of bacterial and eukaryotic mitochondrial isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_BEm; cd07960
591365001423	tRNA binding surface [nucleotide binding]; other site
591365001424	anticodon binding site; other site
591365001425	Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827
591365001426	Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628
591365001427	Domain of unknown function DUF20; Region: UPF0118; pfam01594
591365001428	Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and...; Region: PEPCK_HprK; cl00270
591365001429	active site
591365001430	metal-binding site [ion binding]
591365001431	active site
591365001432	nucleotide-binding site [chemical binding]; other site
591365001433	nucleotide-binding site [chemical binding]; other site
591365001434	Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253
591365001435	Domain of unknown function DUF21; Region: DUF21; pfam01595
591365001436	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590
591365001437	Transporter associated domain; Region: CorC_HlyC; smart01091
591365001438	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
591365001439	DNA-binding site [nucleotide binding]; DNA binding site
591365001440	trehalose operon repressor, B. subtilis-type; Region: trehalos_R_Bsub; TIGR02404
591365001441	UTRA domain; Region: UTRA; pfam07702
591365001442	PTS system, trehalose-specific IIBC component; Region: PTS-IIBC-Tre; TIGR01992
591365001443	PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212
591365001444	active site turn [active]
591365001445	phosphorylation site [posttranslational modification]
591365001446	Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263
591365001447	Phosphotransferase system IIA components [Carbohydrate transport and metabolism]; Region: NagE; COG2190
591365001448	HPr interaction site; other site
591365001449	glycerol kinase (GK) interaction site [polypeptide binding]; other site
591365001450	active site
591365001451	phosphorylation site [posttranslational modification]
591365001452	alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403
591365001453	Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333
591365001454	Ca binding site [ion binding]; other site
591365001455	active site
591365001456	catalytic site [active]
591365001457	YhcR_OBF_like: A subfamily of OB-fold domains similar to the OB folds of Bacillus subtilis YhcR. YhcR is a sugar-nonspecific nuclease, which is active in the presence of Ca2+ and Mn2+. It cleaves RNA endonucleolytically, producing 3'-monophosphate...; Region: YhcR_OBF_like; cd04486
591365001458	generic binding surface I; other site
591365001459	generic binding surface II; other site
591365001460	Mycoplasma pulmonis MnuA nuclease-like; Region: MnuA_DNase1-like; cd10283
591365001461	putative active site [active]
591365001462	putative catalytic site [active]
591365001463	putative Mg binding site IVb [ion binding]; other site
591365001464	putative phosphate binding site [ion binding]; other site
591365001465	putative DNA binding site [nucleotide binding]; other site
591365001466	putative Mg binding site IVa [ion binding]; other site
591365001467	pyruvate formate-lyase 1-activating enzyme; Region: PFLA; TIGR02493
591365001468	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
591365001469	FeS/SAM binding site; other site
591365001470	putative manganese-dependent inorganic pyrophosphatase; Provisional; Region: PRK05427
591365001471	DHH family; Region: DHH; pfam01368
591365001472	DHHA2 domain; Region: DHHA2; pfam02833
591365001473	Orthopoxvirus protein of unknown function (DUF830); Region: DUF830; cl13998
591365001474	Domain of unknown function (DUF1803); Region: DUF1803; pfam08820
591365001475	Domain of unknown function (DUF1803); Region: DUF1803; pfam08820
591365001476	UDP-N-acetylmuramoylalanyl-D-glutamate--L-lysine ligase; Provisional; Region: PRK14022
591365001477	Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225
591365001478	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
591365001479	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
591365001480	Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244
591365001481	Stage V sporulation protein B, also known as Stage III sporulation protein F, and related proteins; Region: MATE_SpoVB_like; cd13124
591365001482	potential frameshift: common BLAST hit: gi|157151121|ref|YP_001450912.1| L-cysteine desulfhydrase
591365001483	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
591365001484	pyridoxal 5'-phosphate binding site [chemical binding]; other site
591365001485	homodimer interface [polypeptide binding]; other site
591365001486	catalytic residue [active]
591365001487	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
591365001488	magnesium-transporting ATPase MgtA; Provisional; Region: PRK10517
591365001489	Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; pfam00690
591365001490	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
591365001491	Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246
591365001492	Soluble P-type ATPase [General function prediction only]; Region: COG4087
591365001493	Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689
591365001494	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
591365001495	active site
591365001496	Clp protease; Region: CLP_protease; pfam00574
591365001497	Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017
591365001498	oligomer interface [polypeptide binding]; other site
591365001499	active site residues [active]
591365001500	ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683
591365001501	Type I periplasmic ligand-binding domain of uncharacterized ABC (Atpase Binding Cassette)-type active transport systems that are predicted to be involved in uptake of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_ligand_binding_like_12; cd06347
591365001502	putative ligand binding site [chemical binding]; other site
591365001503	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
591365001504	Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582
591365001505	TM-ABC transporter signature motif; other site
591365001506	ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177
591365001507	Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581
591365001508	TM-ABC transporter signature motif; other site
591365001509	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411
591365001510	ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219
591365001511	Walker A/P-loop; other site
591365001512	ATP binding site [chemical binding]; other site
591365001513	Q-loop/lid; other site
591365001514	ABC transporter signature motif; other site
591365001515	Walker B; other site
591365001516	D-loop; other site
591365001517	H-loop/switch region; other site
591365001518	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410
591365001519	ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224
591365001520	Walker A/P-loop; other site
591365001521	ATP binding site [chemical binding]; other site
591365001522	Q-loop/lid; other site
591365001523	ABC transporter signature motif; other site
591365001524	Walker B; other site
591365001525	D-loop; other site
591365001526	H-loop/switch region; other site
591365001527	FOG: CBS domain [General function prediction only]; Region: COG0517
591365001528	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in  the acetoin utilization proteins in bacteria. Acetoin is a product of fermentative metabolism in many prokaryotic and eukaryotic microorganisms.  They produce...; Region: CBS_pair_ACT_assoc2; cd04585
591365001529	ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cd02116
591365001530	Uncharacterized conserved protein [Function unknown]; Region: COG1284
591365001531	Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588
591365001532	Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588
591365001533	Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035
591365001534	thymidylate kinase; Validated; Region: tmk; PRK00698
591365001535	Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672
591365001536	TMP-binding site; other site
591365001537	ATP-binding site [chemical binding]; other site
591365001538	DNA polymerase III subunit delta'; Validated; Region: PRK07276
591365001539	DNA polymerase III subunit delta'; Validated; Region: PRK08485
591365001540	DNA replication intiation control protein YabA; Reviewed; Region: PRK13169
591365001541	Predicted methyltransferases [General function prediction only]; Region: COG0313
591365001542	Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648
591365001543	putative SAM binding site [chemical binding]; other site
591365001544	putative homodimer interface [polypeptide binding]; other site
591365001545	Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350
591365001546	The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445
591365001547	DNA binding site [nucleotide binding]
591365001548	active site
591365001549	Arsenate Reductase (ArsC) family, unknown subfamily; uncharacterized proteins containing a CXXC motif with similarity to thioredoxin (TRX)-fold arsenic reductases, ArsC. Proteins containing a redox active CXXC motif like TRX and glutaredoxin (GRX)...; Region: ArsC_like; cd03036
591365001550	putative ArsC-like catalytic residues; other site
591365001551	putative TRX-like catalytic residues [active]
591365001552	Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177
591365001553	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056
591365001554	minor groove reading motif; other site
591365001555	helix-hairpin-helix signature motif; other site
591365001556	substrate binding pocket [chemical binding]; other site
591365001557	active site
591365001558	Bleomycin binding protein (BLMA) and similar proteins; BLMA confers bleomycin (Bm) resistance by directly binding to Bm; Region: BLMA_like; cd08349
591365001559	dimer interface [polypeptide binding]; other site
591365001560	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
591365001561	ligand binding site [chemical binding]; other site
591365001562	Human Ape1-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: Ape1-like_AP-endo; cd09087
591365001563	active site
591365001564	putative catalytic site [active]
591365001565	DNA binding site [nucleotide binding]
591365001566	putative phosphate binding site [ion binding]; other site
591365001567	metal binding site A [ion binding]; metal-binding site
591365001568	AP binding site [nucleotide binding]; other site
591365001569	metal binding site B [ion binding]; metal-binding site
591365001570	Protein of unknown function (DUF3290); Region: DUF3290; pfam11694
591365001571	Predicted membrane protein [Function unknown]; Region: COG2323
591365001572	methionyl-tRNA synthetase; Reviewed; Region: PRK12267
591365001573	catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814
591365001574	active site
591365001575	HIGH motif; other site
591365001576	KMSKS motif; other site
591365001577	Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957
591365001578	tRNA binding surface [nucleotide binding]; other site
591365001579	anticodon binding site; other site
591365001580	Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170
591365001581	tRNA-binding-domain-containing Escherichia coli methionyl-tRNA synthetase (EcMetRS)-like proteins.  This family includes EcMetRS and Aquifex aeolicus Trbp111 (AaTrbp111). This domain has general tRNA binding properties.  MetRS aminoacylates methionine...; Region: tRNA_bind_EcMetRS_like; cd02800
591365001582	G4 box; other site
591365001583	dimer interface [polypeptide binding]; other site
591365001584	putative tRNA-binding site [nucleotide binding]; other site
591365001585	Protein of unknown function (DUF2974); Region: DUF2974; pfam11187
591365001586	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
591365001587	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
591365001588	active site
591365001589	phosphorylation site [posttranslational modification]
591365001590	intermolecular recognition site; other site
591365001591	dimerization interface [polypeptide binding]; other site
591365001592	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
591365001593	DNA binding site [nucleotide binding]
591365001594	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
591365001595	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
591365001596	ATP binding site [chemical binding]; other site
591365001597	Mg2+ binding site [ion binding]; other site
591365001598	G-X-G motif; other site
591365001599	TraX protein; Region: TraX; cl05434
591365001600	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
591365001601	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
591365001602	Walker A/P-loop; other site
591365001603	ATP binding site [chemical binding]; other site
591365001604	Q-loop/lid; other site
591365001605	ABC transporter signature motif; other site
591365001606	Walker B; other site
591365001607	D-loop; other site
591365001608	H-loop/switch region; other site
591365001609	FtsX-like permease family; Region: FtsX; pfam02687
591365001610	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
591365001611	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
591365001612	Walker A/P-loop; other site
591365001613	ATP binding site [chemical binding]; other site
591365001614	Q-loop/lid; other site
591365001615	ABC transporter signature motif; other site
591365001616	Walker B; other site
591365001617	D-loop; other site
591365001618	H-loop/switch region; other site
591365001619	Domain of unknown function (DUF4162); Region: DUF4162; pfam13732
591365001620	ABC-2 type transporter; Region: ABC2_membrane; cl17235
591365001621	LytTr DNA-binding domain; Region: LytTR; smart00850
591365001622	Protein of unknown function (DUF3021); Region: DUF3021; pfam11457
591365001623	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
591365001624	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
591365001625	Walker A/P-loop; other site
591365001626	ATP binding site [chemical binding]; other site
591365001627	Q-loop/lid; other site
591365001628	ABC transporter signature motif; other site
591365001629	Walker B; other site
591365001630	D-loop; other site
591365001631	H-loop/switch region; other site
591365001632	FtsX-like permease family; Region: FtsX; pfam02687
591365001633	amino acid transporter; Region: 2A0306; TIGR00909
591365001634	C-terminus of AA_permease; Region: AA_permease_C; pfam13906
591365001635	Acetyltransferases [General function prediction only]; Region: RimI; COG0456
591365001636	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
591365001637	Coenzyme A binding pocket [chemical binding]; other site
591365001638	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
591365001639	Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583
591365001640	hypothetical protein; Provisional; Region: PRK09273
591365001641	Ribose/Galactose Isomerase; Region: LacAB_rpiB; pfam02502
591365001642	3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK06550
591365001643	classical (c) SDRs; Region: SDR_c; cd05233
591365001644	NAD(P) binding site [chemical binding]; other site
591365001645	active site
591365001646	GNAT acetyltransferase; Region: GNAT_acetyltran; pfam12746
591365001647	ASC-1 homology domain, subfamily similar to Enterococcus faecalis Ef3133. The ASCH domain, a small beta-barrel domain found in all three kingdoms of life, resembles the RNA-binding PUA domain and may also interact with RNA. ASCH has been proposed to...; Region: ASCH_Ef3133_like; cd06553
591365001648	bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase; Provisional; Region: glmU; PRK14354
591365001649	N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540
591365001650	Substrate binding site; other site
591365001651	Mg++ binding site; other site
591365001652	N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353
591365001653	active site
591365001654	substrate binding site [chemical binding]; other site
591365001655	CoA binding site [chemical binding]; other site
591365001656	nudix-type nucleoside diphosphatase, YffH/AdpP family; Region: TIGR00052
591365001657	ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424
591365001658	dimer interface [polypeptide binding]; other site
591365001659	ADP-ribose binding site [chemical binding]; other site
591365001660	active site
591365001661	nudix motif; other site
591365001662	metal binding site [ion binding]; metal-binding site
591365001663	5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Validated; Region: PRK05584
591365001664	5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Region: MTA/SAH-Nsdase; TIGR01704
591365001665	Bacterial protein of unknown function (DUF898); Region: DUF898; cl01738
591365001666	ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488
591365001667	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
591365001668	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
591365001669	ABC transporter; Region: ABC_tran_2; pfam12848
591365001670	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
591365001671	Peptidyl-prolyl cis-trans isomerase (rotamase) - cyclophilin family [Posttranslational modification, protein turnover, chaperones]; Region: PpiB; COG0652
591365001672	active site
591365001673	PspC domain; Region: PspC; pfam04024
591365001674	DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674
591365001675	FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580
591365001676	Ftsk gamma domain; Region: Ftsk_gamma; pfam09397
591365001677	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474
591365001678	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
591365001679	Protein of unknown function (DUF3397); Region: DUF3397; pfam11877
591365001680	50S ribosomal protein L11; Validated; Region: rplK; PRK00140
591365001681	Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349
591365001682	23S rRNA interface [nucleotide binding]; other site
591365001683	L7/L12 interface [polypeptide binding]; other site
591365001684	putative thiostrepton binding site; other site
591365001685	L25 interface [polypeptide binding]; other site
591365001686	Ribosomal protein L1.  The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA.  In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403
591365001687	mRNA/rRNA interface [nucleotide binding]; other site
591365001688	UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254
591365001689	putative nucleotide binding site [chemical binding]; other site
591365001690	uridine monophosphate binding site [chemical binding]; other site
591365001691	homohexameric interface [polypeptide binding]; other site
591365001692	ribosome recycling factor; Reviewed; Region: frr; PRK00083
591365001693	Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation.  Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520
591365001694	hinge region; other site
591365001695	Predicted RNA-bindining protein (contains S1 and HTH domains) [General function prediction only]; Region: COG2996
591365001696	S1 domain; Region: S1_2; pfam13509
591365001697	S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927
591365001698	DNA polymerase III subunit delta; Reviewed; Region: holA; PRK05574
591365001699	DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144
591365001700	Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605
591365001701	Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081
591365001702	Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777
591365001703	A sub-family of peptidase family C39. Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various...; Region: Peptidase_C39B; cd02418
591365001704	ABC-type bacteriocin transporter; Region: bacteriocin_ABC; TIGR01193
591365001705	putative active site [active]
591365001706	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
591365001707	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
591365001708	Walker A/P-loop; other site
591365001709	ATP binding site [chemical binding]; other site
591365001710	Q-loop/lid; other site
591365001711	ABC transporter signature motif; other site
591365001712	Walker B; other site
591365001713	D-loop; other site
591365001714	H-loop/switch region; other site
591365001715	bacteriocin secretion accessory protein; Region: bacteriocin_acc; TIGR01000
591365001716	HlyD family secretion protein; Region: HlyD_3; pfam13437
591365001717	Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518
591365001718	ATP binding site [chemical binding]; other site
591365001719	Mg2+ binding site [ion binding]; other site
591365001720	G-X-G motif; other site
591365001721	Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279
591365001722	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
591365001723	active site
591365001724	phosphorylation site [posttranslational modification]
591365001725	intermolecular recognition site; other site
591365001726	dimerization interface [polypeptide binding]; other site
591365001727	LytTr DNA-binding domain; Region: LytTR; pfam04397
591365001728	CAAX protease self-immunity; Region: Abi; pfam02517
591365001729	Enterocin A Immunity; Region: EntA_Immun; pfam08951
591365001730	TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947
591365001731	catalytic residues [active]
591365001732	Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872
591365001733	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
591365001734	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
591365001735	ligand binding site [chemical binding]; other site
591365001736	Crp-like helix-turn-helix domain; Region: HTH_Crp_2; pfam13545
591365001737	putative switch regulator; other site
591365001738	non-specific DNA interactions [nucleotide binding]; other site
591365001739	DNA binding site [nucleotide binding]
591365001740	sequence specific DNA binding site [nucleotide binding]; other site
591365001741	putative cAMP binding site [chemical binding]; other site
591365001742	arginine deiminase; Provisional; Region: PRK01388
591365001743	ornithine carbamoyltransferase; Validated; Region: PRK02102
591365001744	Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729
591365001745	Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185
591365001746	carbamate kinase; Reviewed; Region: PRK12686
591365001747	AAK_CK: Carbamate kinase (CK) catalyzes both the ATP-phosphorylation of carbamate and carbamoyl phosphate (CP) utilization with the production of ATP from ADP and CP. Both CK (this CD) and nonhomologous CP synthetase synthesize carbamoyl phosphate, an...; Region: AAK_CK; cd04235
591365001748	putative substrate binding site [chemical binding]; other site
591365001749	nucleotide binding site [chemical binding]; other site
591365001750	nucleotide binding site [chemical binding]; other site
591365001751	homodimer interface [polypeptide binding]; other site
591365001752	Predicted membrane protein [Function unknown]; Region: COG1288
591365001753	C4-dicarboxylate anaerobic carrier; Region: DcuC; pfam03606
591365001754	hypothetical protein; Provisional; Region: PRK07205
591365001755	M20 Peptidase Xaa-His dipeptidase (PepV) degrades hydrophobic dipeptides; Region: M20_PepV; cd03888
591365001756	active site
591365001757	metal binding site [ion binding]; metal-binding site
591365001758	Arginine repressor [Transcription]; Region: ArgR; COG1438
591365001759	Arginine repressor, DNA binding domain; Region: Arg_repressor; pfam01316
591365001760	Arginine repressor, C-terminal domain; Region: Arg_repressor_C; pfam02863
591365001761	S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Provisional; Region: queA; PRK00147
591365001762	S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Region: queA; TIGR00113
591365001763	6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363
591365001764	GlcN6P_deaminase: Glucosamine-6-phosphate (GlcN6P) deaminase subfamily; GlcN6P deaminase catalyzes the reversible conversion of GlcN6P to D-fructose-6-phosphate (Fru6P) and ammonium. The reaction is an aldo-keto isomerization coupled with an amination or...; Region: GlcN6P_deaminase; cd01399
591365001765	active site
591365001766	trimer interface [polypeptide binding]; other site
591365001767	allosteric site; other site
591365001768	active site lid [active]
591365001769	hexamer (dimer of trimers) interface [polypeptide binding]; other site
591365001770	Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872
591365001771	D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768
591365001772	Domain of unknown function (DUF1958); Region: DUF1958; pfam09211
591365001773	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
591365001774	Major Facilitator Superfamily; Region: MFS_1; pfam07690
591365001775	putative substrate translocation pore; other site
591365001776	6-phospho-beta-glucosidase; Reviewed; Region: celA; PRK09589
591365001777	beta-galactosidase; Region: BGL; TIGR03356
591365001778	cellobiose phosphotransferase system IIB component; Reviewed; Region: celB; PRK09590
591365001779	active site
591365001780	P-loop; other site
591365001781	phosphorylation site [posttranslational modification]
591365001782	Transcriptional antiterminator [Transcription]; Region: BglG; COG3711
591365001783	HTH domain; Region: HTH_11; pfam08279
591365001784	Mga helix-turn-helix domain; Region: Mga; pfam05043
591365001785	PRD domain; Region: PRD; pfam00874
591365001786	PRD domain; Region: PRD; pfam00874
591365001787	PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568
591365001788	active site
591365001789	P-loop; other site
591365001790	phosphorylation site [posttranslational modification]
591365001791	Phosphoenolpyruvate-dependent sugar phosphotransferase system, EIIA 2; Region: PTS_EIIA_2; pfam00359
591365001792	active site
591365001793	phosphorylation site [posttranslational modification]
591365001794	cellobiose phosphotransferase system IIA component; Reviewed; Region: celC; PRK09591
591365001795	methionine cluster; other site
591365001796	active site
591365001797	phosphorylation site [posttranslational modification]
591365001798	metal binding site [ion binding]; metal-binding site
591365001799	Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455
591365001800	cellobiose phosphotransferase system IIC component; Reviewed; Region: celD; PRK09592
591365001801	Competence protein CoiA-like family; Region: CoiA; pfam06054
591365001802	Oligoendopeptidase F [Amino acid transport and metabolism]; Region: COG1164
591365001803	Peptidase family M3B Oligopeptidase F (PepF); Region: M3B_PepF_3; cd09608
591365001804	active site
591365001805	Zn binding site [ion binding]; other site
591365001806	Predicted O-methyltransferase [General function prediction only]; Region: COG4122
591365001807	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
591365001808	S-adenosylmethionine binding site [chemical binding]; other site
591365001809	foldase protein PrsA; Reviewed; Region: prsA; PRK01326
591365001810	PPIC-type PPIASE domain; Region: Rotamase_2; cl08278
591365001811	Tubby C 2; Region: Tub_2; cl02043
591365001812	alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252
591365001813	Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673
591365001814	motif 1; other site
591365001815	active site
591365001816	motif 2; other site
591365001817	motif 3; other site
591365001818	Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863
591365001819	DHHA1 domain; Region: DHHA1; pfam02272
591365001820	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
591365001821	FemAB family; Region: FemAB; pfam02388
591365001822	Acetyltransferase (GNAT) domain; Region: Acetyltransf_6; pfam13480
591365001823	FemAB family; Region: FemAB; pfam02388
591365001824	Acetyltransferase (GNAT) domain; Region: Acetyltransf_6; pfam13480
591365001825	sugar phosphate phosphatase; Provisional; Region: PRK10513
591365001826	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
591365001827	active site
591365001828	motif I; other site
591365001829	motif II; other site
591365001830	haloacid dehalogenase-like hydrolase; Region: HAD; cl17202
591365001831	HD superfamily phosphohydrolases [General function prediction only]; Region: COG1078
591365001832	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
591365001833	Zn2+ binding site [ion binding]; other site
591365001834	Mg2+ binding site [ion binding]; other site
591365001835	Domain of unknown function (DUF1934); Region: DUF1934; pfam09148
591365001836	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474
591365001837	Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; smart00831
591365001838	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
591365001839	Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246
591365001840	haloacid dehalogenase-like hydrolase; Region: HAD; pfam12710
591365001841	Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689
591365001842	This domain is found in peptide chain release factors; Region: PCRF; smart00937
591365001843	Protein chain release factor B [Translation, ribosomal structure and biogenesis]; Region: PrfB; COG1186
591365001844	RF-1 domain; Region: RF-1; pfam00472
591365001845	Predicted ATPase involved in cell division [Cell division and chromosome partitioning]; Region: FtsE; COG2884
591365001846	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
591365001847	Walker A/P-loop; other site
591365001848	ATP binding site [chemical binding]; other site
591365001849	Q-loop/lid; other site
591365001850	ABC transporter signature motif; other site
591365001851	Walker B; other site
591365001852	D-loop; other site
591365001853	H-loop/switch region; other site
591365001854	Cell division protein [Cell division and chromosome partitioning]; Region: FtsX; COG2177
591365001855	FtsX-like permease family; Region: FtsX; pfam02687
591365001856	Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491
591365001857	bifunctional ATP-dependent DNA helicase/DNA polymerase III subunit epsilon; Validated; Region: PRK07246
591365001858	DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127
591365001859	active site
591365001860	catalytic site [active]
591365001861	substrate binding site [chemical binding]; other site
591365001862	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
591365001863	ATP binding site [chemical binding]; other site
591365001864	Helicase C-terminal domain; Region: Helicase_C_2; pfam13307
591365001865	Predicted membrane protein [Function unknown]; Region: COG2855
591365001866	Bacterial cell division membrane protein [Cell division and chromosome partitioning]; Region: FtsW; COG0772
591365001867	DJ-1 family protein; Region: not_thiJ; TIGR01383
591365001868	Type 1 glutamine amidotransferase (GATase1)-like domain found in Human DJ-1; Region: GATase1_DJ-1; cd03135
591365001869	conserved cys residue [active]
591365001870	Haloacid dehalogenase-like hydrolase; Region: HAD_2; pfam13419
591365001871	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
591365001872	motif II; other site
591365001873	DNA gyrase subunit B; Validated; Region: gyrB; PRK05644
591365001874	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
591365001875	Mg2+ binding site [ion binding]; other site
591365001876	G-X-G motif; other site
591365001877	TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822
591365001878	anchoring element; other site
591365001879	dimer interface [polypeptide binding]; other site
591365001880	ATP binding site [chemical binding]; other site
591365001881	TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366
591365001882	active site
591365001883	putative metal-binding site [ion binding]; other site
591365001884	DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986
591365001885	septation ring formation regulator EzrA; Provisional; Region: PRK04778
591365001886	Protein of unknown function (DUF1664); Region: DUF1664; pfam07889
591365001887	Lactonase, 7-bladed beta-propeller; Region: Lactonase; pfam10282
591365001888	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
591365001889	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
591365001890	active site
591365001891	phosphorylation site [posttranslational modification]
591365001892	intermolecular recognition site; other site
591365001893	dimerization interface [polypeptide binding]; other site
591365001894	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
591365001895	DNA binding site [nucleotide binding]
591365001896	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
591365001897	HAMP domain; Region: HAMP; pfam00672
591365001898	dimerization interface [polypeptide binding]; other site
591365001899	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
591365001900	dimer interface [polypeptide binding]; other site
591365001901	phosphorylation site [posttranslational modification]
591365001902	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
591365001903	ATP binding site [chemical binding]; other site
591365001904	Mg2+ binding site [ion binding]; other site
591365001905	G-X-G motif; other site
591365001906	Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cd02019
591365001907	active site
591365001908	threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK00413
591365001909	TGS _ThrRS_N:  ThrRS (threonyl-tRNA Synthetase)  is a class II tRNA synthetase that couples threonine to its cognate tRNA.  In addition to its catalytic and anticodon-binding domains, ThrRS has an N-terminal TGS domain, named after the ThrRS, GTPase, and...; Region: TGS_ThrRS_N; cd01667
591365001910	Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863
591365001911	Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771
591365001912	active site
591365001913	dimer interface [polypeptide binding]; other site
591365001914	motif 1; other site
591365001915	motif 2; other site
591365001916	motif 3; other site
591365001917	ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860
591365001918	anticodon binding site; other site
591365001919	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
591365001920	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
591365001921	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
591365001922	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
591365001923	Walker A/P-loop; other site
591365001924	ATP binding site [chemical binding]; other site
591365001925	Q-loop/lid; other site
591365001926	ABC transporter signature motif; other site
591365001927	Walker B; other site
591365001928	D-loop; other site
591365001929	H-loop/switch region; other site
591365001930	Mechanosensitive ion channel porin domain; Region: MscS_porin; pfam12795
591365001931	FtsX-like permease family; Region: FtsX; pfam02687
591365001932	ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577
591365001933	FtsX-like permease family; Region: FtsX; pfam02687
591365001934	Calcineurin-like phosphoesterase superfamily domain; Region: Metallophos_2; pfam12850
591365001935	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
591365001936	active site
591365001937	metal binding site [ion binding]; metal-binding site
591365001938	Predicted transcriptional regulator [Transcription]; Region: COG1959
591365001939	Transcriptional regulator; Region: Rrf2; pfam02082
591365001940	glycyl-radical enzyme activating protein family; Region: PFLE_PFLC; TIGR02494
591365001941	The nitrogenase enzyme system catalyzes the ATP-dependent reduction of dinitrogen to ammonia.  This group contains both alpha and beta subunits of component 1 of the three known genetically distinct types of nitrogenase systems: a molybdenum-dependent; Region: Oxidoreductase_nitrogenase; cl02775
591365001942	Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349
591365001943	DeoR-like helix-turn-helix domain; Region: HTH_DeoR; pfam08220
591365001944	DeoR C terminal sensor domain; Region: DeoRC; pfam00455
591365001945	Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription]; Region: DeoR; COG2390
591365001946	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
591365001947	DNA binding residues [nucleotide binding]
591365001948	Putative sugar-binding domain; Region: Sugar-bind; pfam04198
591365001949	PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_lac; cd00215
591365001950	active site
591365001951	methionine cluster; other site
591365001952	phosphorylation site [posttranslational modification]
591365001953	metal binding site [ion binding]; metal-binding site
591365001954	PTS_IIB_chitobiose_lichenan: subunit IIB of enzyme II (EII) of the N,N-diacetylchitobiose-specific and lichenan-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In these systems, EII is either a lichenan- or an N; Region: PTS_IIB_chitobiose_lichenan; cd05564
591365001955	active site
591365001956	P-loop; other site
591365001957	phosphorylation site [posttranslational modification]
591365001958	Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455
591365001959	cellobiose phosphotransferase system IIC component; Reviewed; Region: celD; PRK09592
591365001960	Pyruvate-formate lyase [Energy production and conversion]; Region: PflD; COG1882
591365001961	Pyruvate formate lyase 2 and related enzymes; Region: PFL2_DhaB_BssA; cd01677
591365001962	dimer interface [polypeptide binding]; other site
591365001963	active site
591365001964	glycine loop; other site
591365001965	Transaldolase-like fructose-6-phosphate aldolases (FSA) found in bacteria and archaea; Region: Transaldolase_FSA; cd00956
591365001966	active site
591365001967	intersubunit interactions; other site
591365001968	catalytic residue [active]
591365001969	Glycerol dehydrogenase and related enzymes [Energy production and conversion]; Region: GldA; COG0371
591365001970	Glycerol dehydrogenases (GlyDH) catalyzes oxidation of glycerol to dihydroxyacetone in glycerol dissmilation; Region: GlyDH; cd08170
591365001971	dimer interface [polypeptide binding]; other site
591365001972	active site
591365001973	metal binding site [ion binding]; metal-binding site
591365001974	Endo-beta-N-acetylglucosaminidase D [Carbohydrate transport and metabolism]; Region: COG4724
591365001975	Glycosyl hydrolase family 85; Region: Glyco_hydro_85; pfam03644
591365001976	active site
591365001977	Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes; Region: FA58C; cl12042
591365001978	Putative alpha-1,2-mannosidase [Carbohydrate transport and metabolism]; Region: COG3537
591365001979	Glycosyl hydrolase family 92; Region: Glyco_hydro_92; pfam07971
591365001980	Uncharacterized conserved protein [Function unknown]; Region: COG3538
591365001981	Protein of unknown function (DUF1237); Region: DUF1237; pfam06824
591365001982	Alpha-mannosidase [Carbohydrate transport and metabolism]; Region: AMS1; COG0383
591365001983	N-terminal catalytic domain of SPGH38, a putative alpha-mannosidase of Streptococcus pyogenes, and its prokaryotic homologs; glycoside hydrolase family 38 (GH38); Region: GH38N_AMII_SpGH38_like; cd10814
591365001984	active site
591365001985	metal binding site [ion binding]; metal-binding site
591365001986	homodimer interface [polypeptide binding]; other site
591365001987	catalytic site [active]
591365001988	Alpha mannosidase, middle domain; Region: Alpha-mann_mid; smart00872
591365001989	Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940
591365001990	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012
591365001991	nucleotide binding site [chemical binding]; other site
591365001992	Glycosyl hydrolase family 20 (GH20) catalytic domain of N-acetyl-beta-D-glucosaminidase (GcnA, also known as BhsA) and related proteins. GcnA  is an exoglucosidase which cleaves N-acetyl-beta-D-galactosamine (NAG) and N-acetyl-beta-D-galactosamine...; Region: GH20_GcnA-like; cd06565
591365001993	Glycosyl hydrolase family 20, catalytic domain; Region: Glyco_hydro_20; pfam00728
591365001994	putative active site [active]
591365001995	ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209
591365001996	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
591365001997	ABC-ATPase subunit interface; other site
591365001998	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
591365001999	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
591365002000	dimer interface [polypeptide binding]; other site
591365002001	conserved gate region; other site
591365002002	ABC-ATPase subunit interface; other site
591365002003	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
591365002004	Domain of unknown function (DUF3502); Region: DUF3502; pfam12010
591365002005	Protein of unknown function, DUF624; Region: DUF624; cl02369
591365002006	Predicted signal transduction protein with a C-terminal ATPase domain [Signal transduction mechanisms]; Region: COG2972
591365002007	Histidine kinase; Region: His_kinase; pfam06580
591365002008	Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518
591365002009	ATP binding site [chemical binding]; other site
591365002010	Mg2+ binding site [ion binding]; other site
591365002011	G-X-G motif; other site
591365002012	Response regulator containing CheY-like receiver domain and AraC-type DNA-binding domain [Signal transduction mechanisms]; Region: COG4753
591365002013	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
591365002014	active site
591365002015	phosphorylation site [posttranslational modification]
591365002016	intermolecular recognition site; other site
591365002017	dimerization interface [polypeptide binding]; other site
591365002018	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
591365002019	Uncharacterized protein family (UPF0157); Region: UPF0157; pfam04229
591365002020	lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484
591365002021	LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322
591365002022	dimer interface [polypeptide binding]; other site
591365002023	putative anticodon binding site; other site
591365002024	Lys_tRNA synthetase (LysRS) class II core domain. Class II LysRS is a dimer which attaches a lysine to the 3' OH group of ribose of the appropriate tRNA. Its assignment to class II aaRS is based upon its structure and the presence of three...; Region: LysRS_core; cd00775
591365002025	motif 1; other site
591365002026	active site
591365002027	motif 2; other site
591365002028	motif 3; other site
591365002029	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
591365002030	catalytic core [active]
591365002031	This CD includes cysteinyl-tRNA(Pro) deacylases from Haemophilus influenzae and Escherichia coli and other related bacterial proteins. These trans-acting, single-domain proteins are homologs of ProX and also the cis-acting prolyl-tRNA synthetase (ProRS)...; Region: YbaK_deacylase; cd00002
591365002032	putative deacylase active site [active]
591365002033	Predicted membrane protein [Function unknown]; Region: COG2035
591365002034	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474
591365002035	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
591365002036	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
591365002037	motif II; other site
591365002038	1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204
591365002039	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989
591365002040	putative acyl-acceptor binding pocket; other site
591365002041	Putative intracellular protease/amidase [General function prediction only]; Region: ThiJ; COG0693
591365002042	Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020
591365002043	conserved cys residue [active]
591365002044	Peptidase family C69; Region: Peptidase_C69; cl17793
591365002045	CAAX protease self-immunity; Region: Abi; pfam02517
591365002046	ribonucleotide-diphosphate reductase subunit beta; Provisional; Region: nrdF2; PRK13966
591365002047	Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049
591365002048	dimer interface [polypeptide binding]; other site
591365002049	putative radical transfer pathway; other site
591365002050	diiron center [ion binding]; other site
591365002051	tyrosyl radical; other site
591365002052	Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109
591365002053	ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK07306
591365002054	Ribonucleotide reductase N-terminal; Region: RNR_N; pfam08343
591365002055	Class I ribonucleotide reductase; Region: RNR_I; cd01679
591365002056	active site
591365002057	dimer interface [polypeptide binding]; other site
591365002058	catalytic residues [active]
591365002059	effector binding site; other site
591365002060	Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939
591365002061	Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism]; Region: PtsA; COG1080
591365002062	PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524
591365002063	PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391
591365002064	PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896
591365002065	excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558
591365002066	Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434
591365002067	GIY-YIG motif/motif A; other site
591365002068	active site
591365002069	catalytic site [active]
591365002070	putative DNA binding site [nucleotide binding]; other site
591365002071	metal binding site [ion binding]; metal-binding site
591365002072	UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459
591365002073	Nitroreductase-like family 1. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_1; cd02137
591365002074	dimer interface [polypeptide binding]; other site
591365002075	FMN binding site [chemical binding]; other site
591365002076	dipeptidase PepV; Reviewed; Region: PRK07318
591365002077	M20 Peptidase Xaa-His dipeptidase (PepV) degrades hydrophobic dipeptides; Region: M20_PepV; cd03888
591365002078	active site
591365002079	metal binding site [ion binding]; metal-binding site
591365002080	Uncharacterized subfamily of Uracil-DNA glycosylases; Region: UDG_like_1; cd10033
591365002081	putative uracil binding site [chemical binding]; other site
591365002082	putative active site [active]
591365002083	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
591365002084	MarR family; Region: MarR_2; pfam12802
591365002085	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
591365002086	dimer interface [polypeptide binding]; other site
591365002087	conserved gate region; other site
591365002088	putative PBP binding loops; other site
591365002089	ABC-ATPase subunit interface; other site
591365002090	Periplasmic glycine betaine/choline-binding (lipo)protein of an ABC-type transport system (osmoprotectant binding protein) [Cell envelope biogenesis, outer membrane]; Region: OpuBC; COG1732
591365002091	sulfate ABC transporter, ATP-binding protein; Region: 3a0106s01; TIGR00968
591365002092	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
591365002093	Walker A/P-loop; other site
591365002094	ATP binding site [chemical binding]; other site
591365002095	Q-loop/lid; other site
591365002096	ABC transporter signature motif; other site
591365002097	Walker B; other site
591365002098	D-loop; other site
591365002099	H-loop/switch region; other site
591365002100	SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379
591365002101	Lyzozyme M1 (1,4-beta-N-acetylmuramidase) [Cell envelope biogenesis, outer membrane]; Region: Acm; COG3757
591365002102	PlyB is a bacteriophage endolysin that displays potent lytic activity toward Bacillus anthracis.  PlyB has an N-terminal glycosyl hydrolase family 25 (GH25) catalytic domain and a C-terminal bacterial SH3-like domain, SH3b.  Both domains are required for...; Region: GH25_PlyB-like; cd06523
591365002103	active site
591365002104	Bacterial cell division membrane protein [Cell division and chromosome partitioning]; Region: FtsW; COG0772
591365002105	phosphoenolpyruvate carboxylase; Reviewed; Region: PRK00009
591365002106	Phosphoenolpyruvate carboxylase [Energy production and conversion]; Region: Ppc; COG2352
591365002107	RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937
591365002108	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
591365002109	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
591365002110	DNA binding residues [nucleotide binding]
591365002111	Sigma factor regulator C-terminal; Region: Sigma_reg_C; pfam13791
591365002112	elongation factor Tu; Reviewed; Region: PRK00049
591365002113	Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884
591365002114	G1 box; other site
591365002115	GEF interaction site [polypeptide binding]; other site
591365002116	GTP/Mg2+ binding site [chemical binding]; other site
591365002117	Switch I region; other site
591365002118	G2 box; other site
591365002119	G3 box; other site
591365002120	Switch II region; other site
591365002121	G4 box; other site
591365002122	G5 box; other site
591365002123	EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697
591365002124	Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707
591365002125	Antibiotic Binding Site [chemical binding]; other site
591365002126	triosephosphate isomerase; Provisional; Region: PRK14567
591365002127	Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311
591365002128	substrate binding site [chemical binding]; other site
591365002129	dimer interface [polypeptide binding]; other site
591365002130	catalytic triad [active]
591365002131	Endo-N-acetylmuramidases (muramidases) are lysozymes (also referred to as peptidoglycan hydrolases) that degrade bacterial cell walls by catalyzing the hydrolysis of 1,4-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues; Region: GH25_muramidase; cl10448
591365002132	Glycosyl hydrolases family 25; Region: Glyco_hydro_25; pfam01183
591365002133	active site
591365002134	GBS Bsp-like repeat; Region: GBS_Bsp-like; pfam08481
591365002135	GBS Bsp-like repeat; Region: GBS_Bsp-like; pfam08481
591365002136	GBS Bsp-like repeat; Region: GBS_Bsp-like; pfam08481
591365002137	GBS Bsp-like repeat; Region: GBS_Bsp-like; pfam08481
591365002138	GBS Bsp-like repeat; Region: GBS_Bsp-like; pfam08481
591365002139	GBS Bsp-like repeat; Region: GBS_Bsp-like; pfam08481
591365002140	GBS Bsp-like repeat; Region: GBS_Bsp-like; pfam08481
591365002141	Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various bacteriocins (mostly non-lantibiotic); Region: Peptidase_C39_like; cl00296
591365002142	putative active site [active]
591365002143	CAAX protease self-immunity; Region: Abi; pfam02517
591365002144	tRNA modification GTPase TrmE; Reviewed; Region: trmE; PRK05291
591365002145	GTP-binding protein TrmE N-terminus; Region: TrmE_N; pfam10396
591365002146	trmE is a tRNA modification GTPase; Region: trmE; cd04164
591365002147	G1 box; other site
591365002148	GTP/Mg2+ binding site [chemical binding]; other site
591365002149	Switch I region; other site
591365002150	G2 box; other site
591365002151	Switch II region; other site
591365002152	G3 box; other site
591365002153	G4 box; other site
591365002154	G5 box; other site
591365002155	Catalytic cysteine-containing C-terminus of GTPase, MnmE; Region: GTPase_Cys_C; pfam12631
591365002156	RPI_A: Ribose 5-phosphate isomerase type A (RPI_A) subfamily; RPI catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate, the first step of the non-oxidative branch of the pentose phosphate pathway. This reaction leads to the...; Region: RPI_A; cd01398
591365002157	tetramer (dimer of dimers) interface [polypeptide binding]; other site
591365002158	active site
591365002159	dimer interface [polypeptide binding]; other site
591365002160	purine nucleoside phosphorylase; Provisional; Region: PRK08202
591365002161	purine nucleoside phosphorylase; Reviewed; Region: deoD; PRK05819
591365002162	CRISPR/Cas system-associated protein Csm6; Region: Csm6_III-A; cl09873
591365002163	Phosphoglycerol transferase and related proteins, alkaline phosphatase superfamily [Cell envelope biogenesis, outer membrane]; Region: MdoB; COG1368
591365002164	Sulfatase; Region: Sulfatase; pfam00884
591365002165	Predicted SAM-dependent methyltransferases [General function prediction only]; Region: COG1092
591365002166	Middle domain of the SAM-dependent methyltransferase RlmI and related proteins; Region: RlmI_M_like; cd11572
591365002167	putative RNA binding site [nucleotide binding]; other site
591365002168	Methyltransferase domain; Region: Methyltransf_26; pfam13659
591365002169	3-dehydroquinate dehydratase [Amino acid transport and metabolism]; Region: AroD; COG0710
591365002170	Type I 3-dehydroquinase, (3-dehydroquinate dehydratase or DHQase); Region: DHQase_I; cd00502
591365002171	active site
591365002172	catalytic residue [active]
591365002173	dimer interface [polypeptide binding]; other site
591365002174	shikimate 5-dehydrogenase; Reviewed; Region: aroE; PRK00258
591365002175	Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501
591365002176	NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065
591365002177	shikimate binding site; other site
591365002178	NAD(P) binding site [chemical binding]; other site
591365002179	Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195
591365002180	active site
591365002181	dimer interface [polypeptide binding]; other site
591365002182	metal binding site [ion binding]; metal-binding site
591365002183	Chorismate synthase [Amino acid transport and metabolism]; Region: AroC; COG0082
591365002184	Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304
591365002185	Tetramer interface [polypeptide binding]; other site
591365002186	active site
591365002187	FMN-binding site [chemical binding]; other site
591365002188	Sulfite exporter TauE/SafE; Region: TauE; pfam01925
591365002189	Protein of unknown function (DUF1634); Region: DUF1634; pfam07843
591365002190	prephenate dehydrogenase; Validated; Region: PRK06545
591365002191	prephenate dehydrogenase; Validated; Region: PRK08507
591365002192	C-terminal ACT domain of the monofunctional, NAD dependent, prephenate dehydrogenase (PDH); Region: ACT_PDH-BS; cd04909
591365002193	hypothetical protein; Provisional; Region: PRK13676
591365002194	3-phosphoshikimate 1-carboxyvinyltransferase; Provisional; Region: PRK02427
591365002195	EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556
591365002196	hinge; other site
591365002197	active site
591365002198	shikimate kinase; Reviewed; Region: aroK; PRK00131
591365002199	Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464
591365002200	ADP binding site [chemical binding]; other site
591365002201	magnesium binding site [ion binding]; other site
591365002202	putative shikimate binding site; other site
591365002203	prephenate dehydratase; Provisional; Region: PRK11898
591365002204	Prephenate dehydratase; Region: PDT; pfam00800
591365002205	C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905
591365002206	putative L-Phe binding site [chemical binding]; other site
591365002207	Transcriptional regulator [Transcription]; Region: LytR; COG1316
591365002208	SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase [Translation, ribosomal structure and biogenesis]; Region: TrmA; COG2265
591365002209	TRAM domain; Region: TRAM; cl01282
591365002210	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
591365002211	S-adenosylmethionine binding site [chemical binding]; other site
591365002212	Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789
591365002213	Helix-Turn-Helix DNA binding domain of the BmrR transcription regulator; Region: HTH_BmrR; cd01107
591365002214	DNA binding residues [nucleotide binding]
591365002215	drug binding residues [chemical binding]; other site
591365002216	dimer interface [polypeptide binding]; other site
591365002217	GyrI-like small molecule binding domain; Region: GyrI-like; cl01368
591365002218	Multidrug resistance efflux transporter; Region: EmrE; pfam13536
591365002219	Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950
591365002220	Carbon dioxide concentrating mechanism/carboxysome shell protein [Secondary metabolites biosynthesis, transport, and catabolism / Energy production and conversion]; Region: CcmK; COG4577
591365002221	Carbon dioxide concentrating mechanism K (CcmK)-like proteins, Bacterial Micro-Compartment (BMC) domain; Region: BMC_CcmK_like; cd07045
591365002222	Hexamer interface [polypeptide binding]; other site
591365002223	Hexagonal pore residue; other site
591365002224	Carbon dioxide concentrating mechanism/carboxysome shell protein [Secondary metabolites biosynthesis, transport, and catabolism / Energy production and conversion]; Region: CcmK; COG4577
591365002225	Carbon dioxide concentrating mechanism K (CcmK)-like proteins, Bacterial Micro-Compartment (BMC) domain; Region: BMC_CcmK_like; cd07045
591365002226	Hexamer interface [polypeptide binding]; other site
591365002227	Hexagonal pore residue; other site
591365002228	NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961
591365002229	NAD(P) binding site [chemical binding]; other site
591365002230	catalytic residues [active]
591365002231	glycyl radical enzyme, PFL2/glycerol dehydratase family; Region: PFL2-3; TIGR01774
591365002232	Pyruvate formate lyase 2 and related enzymes; Region: PFL2_DhaB_BssA; cd01677
591365002233	dimer interface [polypeptide binding]; other site
591365002234	active site
591365002235	glycine loop; other site
591365002236	glycyl-radical enzyme activating protein family; Region: PFLE_PFLC; TIGR02494
591365002237	1,2-propanediol utilization protein U (PduU)/ethanolamine utilization protein S (EutS), Bacterial Micro-Compartment (BMC) domain; Region: BMC_PduU-EutS; cd07046
591365002238	putative hexamer interface [polypeptide binding]; other site
591365002239	putative hexagonal pore; other site
591365002240	Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170
591365002241	Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454
591365002242	Dehydroquinate synthase-like (DHQ-like) and iron-containing alcohol dehydrogenases (Fe-ADH); Region: DHQ_Fe-ADH; cl02872
591365002243	active site
591365002244	NAD binding site [chemical binding]; other site
591365002245	metal binding site [ion binding]; metal-binding site
591365002246	Cobalamin adenosyltransferase; Region: Cob_adeno_trans; cl00920
591365002247	ethanolamine utilization protein EutJ; Provisional; Region: PRK15080
591365002248	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012
591365002249	nucleotide binding site [chemical binding]; other site
591365002250	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037
591365002251	Ethanolamine utilisation protein and carboxysome structural protein domain family; Region: EutN_CcmL; cd01614
591365002252	Hexamer/Pentamer interface [polypeptide binding]; other site
591365002253	central pore; other site
591365002254	ethanolamine utilization protein EutQ; Provisional; Region: PRK15457
591365002255	Ethanolamine utilisation protein EutQ; Region: EutQ; pfam06249
591365002256	Carbon dioxide concentrating mechanism/carboxysome shell protein [Secondary metabolites biosynthesis, transport, and catabolism / Energy production and conversion]; Region: CcmK; COG4577
591365002257	Carbon dioxide concentrating mechanism K (CcmK)-like proteins, Bacterial Micro-Compartment (BMC) domain; Region: BMC_CcmK_like; cd07045
591365002258	Hexamer interface [polypeptide binding]; other site
591365002259	Hexagonal pore residue; other site
591365002260	NAD-dependent aldehyde dehydrogenases [Energy production and conversion]; Region: PutA; COG1012
591365002261	Coenzyme A acylating aldehyde dehydrogenase (ACDH), ALDH family 20-like; Region: ALDH_F20_ACDH; cd07122
591365002262	putative catalytic cysteine [active]
591365002263	propanediol utilization phosphotransacylase; Provisional; Region: PRK15070
591365002264	Propanediol utilisation protein PduL; Region: PduL; pfam06130
591365002265	Propanediol utilisation protein PduL; Region: PduL; pfam06130
591365002266	pyruvate:ferredoxin (flavodoxin) oxidoreductase, homodimeric; Region: pyruv_ox_red; TIGR02176
591365002267	Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034
591365002268	dimer interface [polypeptide binding]; other site
591365002269	PYR/PP interface [polypeptide binding]; other site
591365002270	TPP binding site [chemical binding]; other site
591365002271	substrate binding site [chemical binding]; other site
591365002272	Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, gamma subunit [Energy production and conversion]; Region: PorG; COG1014
591365002273	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655
591365002274	Thiamine pyrophosphate (TPP family), PFOR_PNO subfamily, TPP-binding module; composed of proteins similar to the single subunit pyruvate ferredoxin oxidoreductase (PFOR) of Desulfovibrio Africanus, present in bacteria and amitochondriate eukaryotes. This...; Region: TPP_PFOR_PNO; cd03377
591365002275	TPP-binding site [chemical binding]; other site
591365002276	dimer interface [polypeptide binding]; other site
591365002277	dolichyl-phosphate beta-D-mannosyltransferase; Region: PLN02726
591365002278	DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179
591365002279	Ligand binding site; other site
591365002280	Putative Catalytic site; other site
591365002281	DXD motif; other site
591365002282	Uncharacterized conserved protein (DUF2304); Region: DUF2304; pfam10066
591365002283	Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244
591365002284	Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326
591365002285	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
591365002286	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761
591365002287	active site
591365002288	Predicted membrane protein [Function unknown]; Region: COG4713
591365002289	Excalibur calcium-binding domain; Region: Excalibur; smart00894
591365002290	undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714
591365002291	Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187
591365002292	Ligand binding site; other site
591365002293	Putative Catalytic site; other site
591365002294	DXD motif; other site
591365002295	dTDP-6-deoxy-L-lyxo-4-hexulose reductase and related proteins, extended (e) SDRs; Region: dTDP_HR_like_SDR_e; cd05254
591365002296	RmlD substrate binding domain; Region: RmlD_sub_bind; pfam04321
591365002297	NADP binding site [chemical binding]; other site
591365002298	active site
591365002299	putative substrate binding site [chemical binding]; other site
591365002300	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
591365002301	This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_6; cd04955
591365002302	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
591365002303	Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_d; cd04196
591365002304	Probable Catalytic site; other site
591365002305	ABC-type polysaccharide/polyol phosphate export systems, permease component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagG; COG1682
591365002306	ABC-2 type transporter; Region: ABC2_membrane; pfam01061
591365002307	ABC-type polysaccharide/polyol phosphate transport system, ATPase component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagH; COG1134
591365002308	ATP-binding cassette component of polysaccharide transport system; Region: ABC_KpsT_Wzt; cd03220
591365002309	Walker A/P-loop; other site
591365002310	ATP binding site [chemical binding]; other site
591365002311	Q-loop/lid; other site
591365002312	ABC transporter signature motif; other site
591365002313	Walker B; other site
591365002314	D-loop; other site
591365002315	H-loop/switch region; other site
591365002316	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
591365002317	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
591365002318	Rhamnan synthesis protein F; Region: RgpF; pfam05045
591365002319	Sulfatase; Region: Sulfatase; pfam00884
591365002320	Predicted SAM-dependent methyltransferase [General function prediction only]; Region: COG2384
591365002321	Family of unknown function (DUF633); Region: DUF633; pfam04816
591365002322	Uncharacterized conserved protein [Function unknown]; Region: COG0327
591365002323	NIF3 (NGG1p interacting factor 3); Region: NIF3; pfam01784
591365002324	MutT homolog-1 (MTH1) is a member of the Nudix hydrolase superfamily. MTH1, the mammalian counterpart of MutT, hydrolyzes oxidized purine nucleoside triphosphates, such as 8-oxo-dGTP and 2-hydroxy-ATP, to monophosphates, thereby preventing the...; Region: MTH1; cd03427
591365002325	putative active site [active]
591365002326	nucleotide binding site [chemical binding]; other site
591365002327	nudix motif; other site
591365002328	putative metal binding site [ion binding]; other site
591365002329	G1P_TT_short is the short form of glucose-1-phosphate thymidylyltransferase; Region: G1P_TT_short; cd02538
591365002330	glucose-1-phosphate thymidylyltransferase, short form; Region: rmlA; TIGR01207
591365002331	substrate binding site; other site
591365002332	tetramer interface; other site
591365002333	dTDP-4-dehydrorhamnose 3,5-epimerase and related enzymes [Cell envelope biogenesis, outer membrane]; Region: RfbC; COG1898
591365002334	dTDP-D-glucose 4,6-dehydratase [Cell envelope biogenesis, outer membrane]; Region: RfbB; COG1088
591365002335	dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246
591365002336	NAD binding site [chemical binding]; other site
591365002337	substrate binding site [chemical binding]; other site
591365002338	homodimer interface [polypeptide binding]; other site
591365002339	active site
591365002340	UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247
591365002341	UDP-glucose 4-epimerase; Region: PLN02240
591365002342	NAD binding site [chemical binding]; other site
591365002343	homodimer interface [polypeptide binding]; other site
591365002344	active site
591365002345	substrate binding site [chemical binding]; other site
591365002346	Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006
591365002347	Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321
591365002348	Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092
591365002349	active site
591365002350	catabolite control protein A; Region: ccpA; TIGR01481
591365002351	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
591365002352	DNA binding site [nucleotide binding]
591365002353	domain linker motif; other site
591365002354	Ligand-binding domain of the catabolite control protein A (CcpA), which functions as the major transcriptional regulator of carbon catabolite repression/regulation; Region: PBP1_CcpA_like; cd06298
591365002355	dimerization interface [polypeptide binding]; other site
591365002356	effector binding site; other site
591365002357	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
591365002358	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
591365002359	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
591365002360	This family is most closely related to the GT1 family of glycosyltransferases. UDP-glucose-diacylglycerol glucosyltransferase (UGDG; also known as 1,2-diacylglycerol 3-glucosyltransferase) catalyzes the transfer of glucose from UDP-glucose to 1; Region: GT1_UGDG_like; cd03817
591365002361	putative ADP-binding pocket [chemical binding]; other site
591365002362	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
591365002363	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
591365002364	active site
591365002365	phosphorylation site [posttranslational modification]
591365002366	intermolecular recognition site; other site
591365002367	dimerization interface [polypeptide binding]; other site
591365002368	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
591365002369	DNA binding site [nucleotide binding]
591365002370	phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966
591365002371	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
591365002372	putative active site [active]
591365002373	heme pocket [chemical binding]; other site
591365002374	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
591365002375	dimer interface [polypeptide binding]; other site
591365002376	phosphorylation site [posttranslational modification]
591365002377	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
591365002378	ATP binding site [chemical binding]; other site
591365002379	Mg2+ binding site [ion binding]; other site
591365002380	G-X-G motif; other site
591365002381	Metal-dependent hydrolases of the beta-lactamase superfamily I [General function prediction only]; Region: PhnP; COG1235
591365002382	Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220
591365002383	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2832
591365002384	ribonuclease III; Reviewed; Region: rnc; PRK00102
591365002385	RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593
591365002386	dimerization interface [polypeptide binding]; other site
591365002387	active site
591365002388	metal binding site [ion binding]; metal-binding site
591365002389	Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048
591365002390	dsRNA binding site [nucleotide binding]; other site
591365002391	chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168
591365002392	ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278
591365002393	Walker A/P-loop; other site
591365002394	ATP binding site [chemical binding]; other site
591365002395	Q-loop/lid; other site
591365002396	SMC proteins Flexible Hinge Domain; Region: SMC_hinge; smart00968
591365002397	ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278
591365002398	ABC transporter signature motif; other site
591365002399	Walker B; other site
591365002400	D-loop; other site
591365002401	H-loop/switch region; other site
591365002402	Predicted hydrolases of the HAD superfamily [General function prediction only]; Region: Cof; COG0561
591365002403	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
591365002404	active site
591365002405	motif I; other site
591365002406	motif II; other site
591365002407	haloacid dehalogenase-like hydrolase; Region: HAD; cl17202
591365002408	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
591365002409	haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282
591365002410	active site
591365002411	motif I; other site
591365002412	motif II; other site
591365002413	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cl17915
591365002414	signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416
591365002415	SRP54-type protein, helical bundle domain; Region: SRP54_N; pfam02881
591365002416	The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115
591365002417	P loop; other site
591365002418	GTP binding site [chemical binding]; other site
591365002419	pyruvate phosphate dikinase; Provisional; Region: PRK09279
591365002420	Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326
591365002421	PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391
591365002422	PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896
591365002423	HTH domain; Region: HTH_11; pfam08279
591365002424	FOG: CBS domain [General function prediction only]; Region: COG0517
591365002425	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354
591365002426	PEP synthetase regulatory protein; Provisional; Region: PRK05339
591365002427	Firmicute fructose-1,6-bisphosphatase; Region: FBPase_2; pfam06874
591365002428	metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995
591365002429	Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104
591365002430	cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402
591365002431	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
591365002432	catalytic residue [active]
591365002433	thiamine biosynthesis protein ThiI; Provisional; Region: PRK01565
591365002434	THUMP domain of thiamine biosynthesis protein ThiI; Region: THUMP_ThiI; cd11716
591365002435	ThiI is required for thiazole synthesis in the thiamine biosynthesis pathway. It belongs to the Adenosine Nucleotide Hydrolysis suoerfamily and predicted to bind to Adenosine nucleotide; Region: ThiI; cd01712
591365002436	Ligand Binding Site [chemical binding]; other site
591365002437	Adenine specific DNA methylase Mod [DNA replication, recombination, and repair]; Region: COG2189
591365002438	DNA methylase; Region: N6_N4_Mtase; pfam01555
591365002439	DNA methylase; Region: N6_N4_Mtase; cl17433
591365002440	DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061
591365002441	DEAD/DEAH box helicase; Region: DEAD; pfam00270
591365002442	50S ribosomal protein L21; Validated; Region: rplU; PRK05573
591365002443	Predicted ribosomal protein [Translation, ribosomal structure and biogenesis]; Region: COG2868
591365002444	50S ribosomal protein L27; Validated; Region: rpmA; PRK05435
591365002445	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
591365002446	CoA-disulfide reductase; Region: CoA_CoA_reduc; TIGR03385
591365002447	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
591365002448	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
591365002449	Member of the Rhodanese Homology Domain superfamily. Included in this CD are the Lactococcus lactis NADH oxidase, Bacillus cereus NADH dehydrogenase, and Bacteroides thetaiotaomicron pyridine nucleotide-disulphide oxidoreductase, and similar...; Region: RHOD_Pyr_redox; cd01524
591365002450	active site residue [active]
591365002451	This CD includes bacterial (Agrobacterium tumefaciens and Caulobacter crescentus ProX, and Clostridium sticklandii PrdX) and eukaryotic (Plasmodium falciparum N-terminal ProRS editing domain) sequences. The C. sticklandii PrdX protein, a homolog of the...; Region: PrdX_deacylase; cd04335
591365002452	putative deacylase active site [active]
591365002453	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
591365002454	Coenzyme A binding pocket [chemical binding]; other site
591365002455	Acetyltransferases [General function prediction only]; Region: RimI; COG0456
591365002456	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
591365002457	Coenzyme A binding pocket [chemical binding]; other site
591365002458	Transcriptional regulator [Transcription]; Region: LysR; COG0583
591365002459	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
591365002460	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
591365002461	dimerization interface [polypeptide binding]; other site
591365002462	lipoprotein signal peptidase; Provisional; Region: PRK14797
591365002463	Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564
591365002464	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
591365002465	RNA binding surface [nucleotide binding]; other site
591365002466	Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869
591365002467	active site
591365002468	Amino Acid Kinases (AAK) superfamily, catalytic domain; present in such enzymes like N-acetylglutamate kinase (NAGK), carbamate kinase (CK), aspartokinase (AK), glutamate-5-kinase (G5K) and UMP kinase (UMPK). The AAK superfamily includes kinases that...; Region: AAK; cl00452
591365002469	nucleotide binding site [chemical binding]; other site
591365002470	Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270
591365002471	Phosphotransferase enzyme family; Region: APH; pfam01636
591365002472	active site
591365002473	substrate binding site [chemical binding]; other site
591365002474	ATP binding site [chemical binding]; other site
591365002475	Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120
591365002476	Uncharacterized Zn-ribbon-containing protein involved in phosphonate metabolism [Inorganic ion transport and metabolism]; Region: PhnA; COG2824
591365002477	PhnA Zinc-Ribbon; Region: PhnA_Zn_Ribbon; pfam08274
591365002478	PhnA protein; Region: PhnA; pfam03831
591365002479	Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038
591365002480	ClC sycA-like chloride channel proteins. This ClC family presents in bacteria, where it facilitates acid resistance in acidic soil. Mutation of this gene (sycA) in Rhizobium tropici CIAT899 causes serious deficiencies in nodule development, nodulation...; Region: ClC_sycA_like; cd03682
591365002481	putative Cl- selectivity filter; other site
591365002482	putative pore gating glutamate residue; other site
591365002483	thymidylate synthase; Reviewed; Region: thyA; PRK01827
591365002484	Thymidylate synthase and pyrimidine hydroxymethylase: Thymidylate synthase (TS) and deoxycytidylate hydroxymethylase (dCMP-HMase) are homologs that catalyze analogous alkylation of C5 of pyrimidine nucleotides. Both enzymes are involved in the...; Region: TS_Pyrimidine_HMase; cd00351
591365002485	dimerization interface [polypeptide binding]; other site
591365002486	active site
591365002487	Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262
591365002488	Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cd00209
591365002489	folate binding site [chemical binding]; other site
591365002490	NADP+ binding site [chemical binding]; other site
591365002491	ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342
591365002492	ClpX C4-type zinc finger; Region: zf-C4_ClpX; pfam06689
591365002493	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
591365002494	Walker A motif; other site
591365002495	ATP binding site [chemical binding]; other site
591365002496	Walker B motif; other site
591365002497	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086
591365002498	YihA (EngB) GTPase family; Region: YihA_EngB; cd01876
591365002499	G1 box; other site
591365002500	GTP/Mg2+ binding site [chemical binding]; other site
591365002501	Switch I region; other site
591365002502	G2 box; other site
591365002503	G3 box; other site
591365002504	Switch II region; other site
591365002505	G4 box; other site
591365002506	G5 box; other site
591365002507	Muramidase (flagellum-specific) [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FlgJ; COG1705
591365002508	Formate/nitrite family of transporters [Inorganic ion transport and metabolism]; Region: FocA; COG2116
591365002509	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
591365002510	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
591365002511	ATP-binding cassette domain of multidrug resistance protein-like transporters; Region: ABCC_MRP_Like; cd03228
591365002512	Walker A/P-loop; other site
591365002513	ATP binding site [chemical binding]; other site
591365002514	Q-loop/lid; other site
591365002515	ABC transporter signature motif; other site
591365002516	Walker B; other site
591365002517	D-loop; other site
591365002518	H-loop/switch region; other site
591365002519	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
591365002520	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
591365002521	ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254
591365002522	Walker A/P-loop; other site
591365002523	ATP binding site [chemical binding]; other site
591365002524	Q-loop/lid; other site
591365002525	ABC transporter signature motif; other site
591365002526	Walker B; other site
591365002527	D-loop; other site
591365002528	H-loop/switch region; other site
591365002529	ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488
591365002530	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
591365002531	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
591365002532	Q-loop/lid; other site
591365002533	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
591365002534	ABC transporter signature motif; other site
591365002535	Walker B; other site
591365002536	ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126
591365002537	ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262
591365002538	Walker A/P-loop; other site
591365002539	ATP binding site [chemical binding]; other site
591365002540	Q-loop/lid; other site
591365002541	ABC transporter signature motif; other site
591365002542	Walker B; other site
591365002543	D-loop; other site
591365002544	H-loop/switch region; other site
591365002545	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
591365002546	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
591365002547	substrate binding pocket [chemical binding]; other site
591365002548	membrane-bound complex binding site; other site
591365002549	hinge residues; other site
591365002550	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
591365002551	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
591365002552	substrate binding pocket [chemical binding]; other site
591365002553	membrane-bound complex binding site; other site
591365002554	hinge residues; other site
591365002555	ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215
591365002556	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
591365002557	dimer interface [polypeptide binding]; other site
591365002558	conserved gate region; other site
591365002559	putative PBP binding loops; other site
591365002560	ABC-ATPase subunit interface; other site
591365002561	excinuclease ABC subunit B; Provisional; Region: PRK05298
591365002562	Myosin and Kinesin motor domain. These ATPases belong to the P-loop NTPase family and provide the driving force in myosin and kinesin mediated processes; Region: Motor_domain; cl00286
591365002563	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
591365002564	ATP-binding site [chemical binding]; other site
591365002565	ATP binding site [chemical binding]; other site
591365002566	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
591365002567	nucleotide binding region [chemical binding]; other site
591365002568	ATP-binding site [chemical binding]; other site
591365002569	Ultra-violet resistance protein B; Region: UvrB; pfam12344
591365002570	UvrB/uvrC motif; Region: UVR; pfam02151
591365002571	Protein of unknown function (DUF1697); Region: DUF1697; pfam08002
591365002572	coproporphyrinogen III oxidase; Provisional; Region: PRK08599
591365002573	HemN C-terminal domain; Region: HemN_C; pfam06969
591365002574	Acyl-ACP thioesterase [Lipid metabolism]; Region: FatA; COG3884
591365002575	4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586
591365002576	active site
591365002577	4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586
591365002578	Hydrolase of X-linked nucleoside diphosphate N terminal; Region: Nudix_N; pfam12535
591365002579	Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_14; cd04672
591365002580	nudix motif; other site
591365002581	HAD-superfamily subfamily IIA hydrolase, TIGR01457; Region: HAD-SF-IIA-hyp2
591365002582	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
591365002583	active site
591365002584	motif I; other site
591365002585	motif II; other site
591365002586	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
591365002587	Protein of unknown function (DUF1461); Region: DUF1461; cl01862
591365002588	CAAX protease self-immunity; Region: Abi; pfam02517
591365002589	Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413
591365002590	active site
591365002591	multimer interface [polypeptide binding]; other site
591365002592	glmZ(sRNA)-inactivating NTPase; Provisional; Region: PRK05416
591365002593	conserved hypothetical protein, cofD-related; Region: CofD_related; TIGR01826
591365002594	Family of CofD-like proteins and proteins related to YvcK; Region: CofD_YvcK; cd07044
591365002595	dimer interface [polypeptide binding]; other site
591365002596	phosphate binding site [ion binding]; other site
591365002597	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1481
591365002598	Sporulation Regulator WhiA N terminal; Region: WhiA_N; pfam10298
591365002599	Streptococcal histidine triad protein; Region: Strep_his_triad; pfam04270
591365002600	Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799
591365002601	Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond...; Region: LRR_RI; cl15309
591365002602	Substrate binding site [chemical binding]; other site
591365002603	Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799
591365002604	Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799
591365002605	Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799
591365002606	Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799
591365002607	Primase C terminal 1 (PriCT-1); Region: PriCT_1; pfam08708
591365002608	Site-specific DNA methylase [DNA replication, recombination, and repair]; Region: Dam; COG0338
591365002609	Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403
591365002610	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085
591365002611	active site
591365002612	TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947
591365002613	catalytic residues [active]
591365002614	recombination and DNA strand exchange inhibitor protein; Reviewed; Region: PRK00409
591365002615	DNA/RNA non-specific endonuclease; Region: Endonuclea_NS_2; cl17626
591365002616	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl17200
591365002617	DNA-binding transcriptional regulator YidZ; Provisional; Region: PRK10216
591365002618	DNA primase (bacterial type) [DNA replication, recombination, and repair]; Region: DnaG; COG0358
591365002619	CHC2 zinc finger; Region: zf-CHC2; cl17510
591365002620	Protein of unknown function (DUF3991); Region: DUF3991; pfam13154
591365002621	Toprim-like; Region: Toprim_2; pfam13155
591365002622	TOPRIM_TopoIA_TopoIII: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to topoisomerase III. Type IA DNA topoisomerases remove (relax) negative supercoils in the DNA by: cleaving...; Region: TOPRIM_TopoIA_TopoIII; cd03362
591365002623	Topoisomerase IA [DNA replication, recombination, and repair]; Region: TopA; COG0550
591365002624	active site
591365002625	putative interdomain interaction site [polypeptide binding]; other site
591365002626	putative metal-binding site [ion binding]; other site
591365002627	putative nucleotide binding site [chemical binding]; other site
591365002628	DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186
591365002629	domain I; other site
591365002630	DNA binding groove [nucleotide binding]
591365002631	phosphate binding site [ion binding]; other site
591365002632	domain II; other site
591365002633	domain III; other site
591365002634	nucleotide binding site [chemical binding]; other site
591365002635	catalytic site [active]
591365002636	domain IV; other site
591365002637	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
591365002638	ATPases associated with a variety of cellular activities; Region: AAA; smart00382
591365002639	Walker A motif; other site
591365002640	ATP binding site [chemical binding]; other site
591365002641	Walker B motif; other site
591365002642	arginine finger; other site
591365002643	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
591365002644	AAA domain; Region: AAA_22; pfam13401
591365002645	Walker A motif; other site
591365002646	ATP binding site [chemical binding]; other site
591365002647	Walker B motif; other site
591365002648	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431
591365002649	autotransport protein MisL; Provisional; Region: PRK15313
591365002650	Tumour suppressor, Mitostatin; Region: Trichoplein; pfam13868
591365002651	Glucan-binding protein C; Region: GbpC; pfam08363
591365002652	LPXTG-motif cell wall anchor domain; Region: LPXTG_anchor; TIGR01167
591365002653	SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496
591365002654	dimer interface [polypeptide binding]; other site
591365002655	ssDNA binding site [nucleotide binding]; other site
591365002656	tetramer (dimer of dimers) interface [polypeptide binding]; other site
591365002657	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
591365002658	Walker A motif; other site
591365002659	ATP binding site [chemical binding]; other site
591365002660	Type IV secretory pathway, VirD4 components [Intracellular trafficking and secretion]; Region: VirD4; COG3505
591365002661	TraM recognition site of TraD and TraG; Region: TraG-D_C; pfam12696
591365002662	Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027
591365002663	Dimer interface [polypeptide binding]; other site
591365002664	Integral membrane protein (PIN domain superfamily) [General function prediction only]; Region: COG4956
591365002665	AAA-like domain; Region: AAA_10; pfam12846
591365002666	Mannosyl-glycoprotein endo-beta-N-acetylglucosaminidase; Region: Glucosaminidase; pfam01832
591365002667	CHAP domain; Region: CHAP; pfam05257
591365002668	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
591365002669	AAA domain; Region: AAA_31; pfam13614
591365002670	P-loop; other site
591365002671	Magnesium ion binding site [ion binding]; other site
591365002672	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
591365002673	Uncharacterized protein family (UPF0236); Region: UPF0236; pfam06782
591365002674	Pyrimidine operon attenuation protein/uracil phosphoribosyltransferase [Nucleotide transport and metabolism]; Region: PyrR; COG2065
591365002675	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
591365002676	active site
591365002677	uracil transporter; Provisional; Region: PRK10720
591365002678	aspartate carbamoyltransferase catalytic subunit; Provisional; Region: pyrB; PRK00856
591365002679	Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729
591365002680	Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185
591365002681	carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564
591365002682	Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; smart01097
591365002683	Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744
591365002684	catalytic site [active]
591365002685	subunit interface [polypeptide binding]; other site
591365002686	carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294
591365002687	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
591365002688	Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786
591365002689	Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787
591365002690	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
591365002691	ATP-grasp domain; Region: ATP-grasp_4; cl17255
591365002692	Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424
591365002693	IMP binding site; other site
591365002694	dimer interface [polypeptide binding]; other site
591365002695	interdomain contacts; other site
591365002696	partial ornithine binding site; other site
591365002697	ROK family protein (putative glucokinase); Region: ROK_glcA_fam; TIGR00744
591365002698	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012
591365002699	nucleotide binding site [chemical binding]; other site
591365002700	50S ribosomal protein L19; Provisional; Region: rplS; PRK05338
591365002701	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
591365002702	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
591365002703	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
591365002704	active site
591365002705	phosphorylation site [posttranslational modification]
591365002706	intermolecular recognition site; other site
591365002707	dimerization interface [polypeptide binding]; other site
591365002708	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
591365002709	DNA binding site [nucleotide binding]
591365002710	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
591365002711	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
591365002712	dimer interface [polypeptide binding]; other site
591365002713	phosphorylation site [posttranslational modification]
591365002714	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
591365002715	ATP binding site [chemical binding]; other site
591365002716	Mg2+ binding site [ion binding]; other site
591365002717	G-X-G motif; other site
591365002718	cytoplasmic alpha-amylase; Reviewed; Region: PRK09441
591365002719	Alpha amylase catalytic domain found in bacterial and fungal Alpha amylases (also called 1,4-alpha-D-glucan-4-glucanohydrolase); Region: AmyAc_bac_fung_AmyA; cd11318
591365002720	active site
591365002721	Na/Ca binding site [ion binding]; other site
591365002722	catalytic site [active]
591365002723	Domain of unknown function (DUF1939); Region: DUF1939; pfam09154
591365002724	topology modulation protein; Provisional; Region: PRK07261
591365002725	AAA domain; Region: AAA_17; pfam13207
591365002726	30S ribosomal protein S20; Reviewed; Region: rpsT; PRK00239
591365002727	pantothenate kinase; Provisional; Region: PRK05439
591365002728	Pantothenate kinase (PanK) catalyzes the phosphorylation of pantothenic acid to form 4'-phosphopantothenic, which is the first of five steps in coenzyme A (CoA) biosynthetic pathway. The reaction carried out by this enzyme is a key regulatory point...; Region: PanK; cd02025
591365002729	ATP-binding site [chemical binding]; other site
591365002730	CoA-binding site [chemical binding]; other site
591365002731	Mg2+-binding site [ion binding]; other site
591365002732	16S RNA G1207 methylase RsmC [Translation, ribosomal structure and biogenesis]; Region: RsmC; COG2813
591365002733	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
591365002734	S-adenosylmethionine binding site [chemical binding]; other site
591365002735	pyrimidine-nucleoside phosphorylase; Reviewed; Region: PRK06078
591365002736	Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885
591365002737	Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591
591365002738	Pyrimidine nucleoside phosphorylase C-terminal domain; Region: PYNP_C; pfam07831
591365002739	2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family; Region: DeoC; cd00959
591365002740	intersubunit interface [polypeptide binding]; other site
591365002741	active site
591365002742	catalytic residue [active]
591365002743	Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283
591365002744	active site
591365002745	catalytic motif [active]
591365002746	Zn binding site [ion binding]; other site
591365002747	Uncharacterized ABC-type transport system, periplasmic component/surface lipoprotein [General function prediction only]; Region: Med; COG1744
591365002748	Periplasmic binding domain of basic membrane lipoprotein, PnrA, in Treponema pallidum and its homologs from other bacteria and Archaea; Region: PBP1_BmpA_PnrA_like; cd06354
591365002749	ligand binding site [chemical binding]; other site
591365002750	ABC-type uncharacterized transport systems, ATPase components [General function prediction only]; Region: COG3845
591365002751	First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216
591365002752	Walker A/P-loop; other site
591365002753	ATP binding site [chemical binding]; other site
591365002754	Q-loop/lid; other site
591365002755	ABC transporter signature motif; other site
591365002756	Walker B; other site
591365002757	D-loop; other site
591365002758	H-loop/switch region; other site
591365002759	Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215
591365002760	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
591365002761	Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580
591365002762	TM-ABC transporter signature motif; other site
591365002763	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
591365002764	Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580
591365002765	TM-ABC transporter signature motif; other site
591365002766	Predicted membrane protein, hemolysin III homolog [General function prediction only]; Region: COG1272
591365002767	channel protein, hemolysin III family; Region: hlyIII; TIGR01065
591365002768	Domain of unknown function (DUF1836); Region: DUF1836; pfam08876
591365002769	hypothetical protein; Validated; Region: PRK02101
591365002770	Predicted flavoprotein [General function prediction only]; Region: COG0431
591365002771	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
591365002772	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
591365002773	MarR family; Region: MarR; pfam01047
591365002774	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5353
591365002775	Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413
591365002776	aspartate aminotransferase; Provisional; Region: PRK05764
591365002777	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
591365002778	pyridoxal 5'-phosphate binding site [chemical binding]; other site
591365002779	homodimer interface [polypeptide binding]; other site
591365002780	catalytic residue [active]
591365002781	This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_19; cd07262
591365002782	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
591365002783	asparaginyl-tRNA synthetase; Validated; Region: asnC; PRK03932
591365002784	AsnRS_cyto_like_N: N-terminal, anticodon recognition domain of the type found in human and Saccharomyces cerevisiae cytoplasmic asparaginyl-tRNA synthetase (AsnRS), in Brugia malayai AsnRs and, in various putative bacterial AsnRSs.  This domain is a...; Region: AsnRS_cyto_like_N; cd04323
591365002785	putative dimer interface [polypeptide binding]; other site
591365002786	putative anticodon binding site; other site
591365002787	Asx tRNA synthetase (AspRS/AsnRS) class II core domain.  Assignment to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs in the core domain. This family includes AsnRS as well as...; Region: AsxRS_core; cd00776
591365002788	homodimer interface [polypeptide binding]; other site
591365002789	motif 1; other site
591365002790	motif 2; other site
591365002791	active site
591365002792	motif 3; other site
591365002793	Major Facilitator Superfamily; Region: MFS_1; pfam07690
591365002794	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
591365002795	Polymerase and Histidinol Phosphatase domain; Region: PHP; cl17102
591365002796	active site
591365002797	SnoaL-like domain; Region: SnoaL_2; pfam12680
591365002798	Protein of unknown function (DUF1694); Region: DUF1694; cl02318
591365002799	enolase; Provisional; Region: eno; PRK00077
591365002800	Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313
591365002801	dimer interface [polypeptide binding]; other site
591365002802	metal binding site [ion binding]; metal-binding site
591365002803	substrate binding pocket [chemical binding]; other site
591365002804	NAD-dependent deacetylase; Provisional; Region: PRK00481
591365002805	SIR2 superfamily of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+; Region: SIR2; cl00195
591365002806	Protein of unknown function (DUF3307); Region: DUF3307; pfam11750
591365002807	Uncharacterized protein conserved in bacteria [Function unknown]; Region: DegV; COG1307
591365002808	Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645
591365002809	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
591365002810	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
591365002811	Deoxycytidylate deaminase domain. Deoxycytidylate deaminase catalyzes the deamination of dCMP to dUMP, providing the nucleotide substrate for thymidylate synthase. The enzyme binds Zn++, which is required for catalytic activity. The activity of the...; Region: deoxycytidylate_deaminase; cd01286
591365002812	catalytic motif [active]
591365002813	Zn binding site [ion binding]; other site
591365002814	putative glycerol-3-phosphate acyltransferase PlsY; Provisional; Region: PRK00220
591365002815	DNA topoisomerase IV, B subunit, Gram-positive; Region: parE_Gpos; TIGR01058
591365002816	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
591365002817	Mg2+ binding site [ion binding]; other site
591365002818	G-X-G motif; other site
591365002819	TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822
591365002820	anchoring element; other site
591365002821	dimer interface [polypeptide binding]; other site
591365002822	ATP binding site [chemical binding]; other site
591365002823	TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366
591365002824	active site
591365002825	putative metal-binding site [ion binding]; other site
591365002826	DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986
591365002827	DNA topoisomerase IV, A subunit, Gram-positive; Region: parC_Gpos; TIGR01061
591365002828	DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187
591365002829	CAP-like domain; other site
591365002830	active site
591365002831	primary dimer interface [polypeptide binding]; other site
591365002832	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
591365002833	branched-chain amino acid aminotransferase; Provisional; Region: PRK13357
591365002834	BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids  leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557
591365002835	homodimer interface [polypeptide binding]; other site
591365002836	substrate-cofactor binding pocket; other site
591365002837	catalytic residue [active]
591365002838	30S ribosomal protein S1; Reviewed; Region: rpsA; PRK06676
591365002839	S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687
591365002840	RNA binding site [nucleotide binding]; other site
591365002841	S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465
591365002842	RNA binding site [nucleotide binding]; other site
591365002843	S1_RPS1_repeat_ec3: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec3; cd05688
591365002844	RNA binding site [nucleotide binding]; other site
591365002845	S1_RPS1_repeat_hs4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_hs4; cd05692
591365002846	RNA binding site [nucleotide binding]; other site
591365002847	Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cd02883
591365002848	nudix motif; other site
591365002849	L-lactate dehydrogenase; Reviewed; Region: ldh; PRK00066
591365002850	L-2-hydroxyisocapronate dehydrogenases and some bacterial L-lactate dehydrogenases; Region: HicDH_like; cd05291
591365002851	tetramer (dimer of dimers) interface [polypeptide binding]; other site
591365002852	NAD binding site [chemical binding]; other site
591365002853	dimer interface [polypeptide binding]; other site
591365002854	substrate binding site [chemical binding]; other site
591365002855	DNA gyrase subunit A; Validated; Region: PRK05560
591365002856	DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187
591365002857	CAP-like domain; other site
591365002858	active site
591365002859	primary dimer interface [polypeptide binding]; other site
591365002860	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
591365002861	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
591365002862	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
591365002863	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
591365002864	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
591365002865	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
591365002866	Sortase A (SrtA) or subfamily-1 sortases are cysteine transpeptidases found in gram-positive bacteria that anchor surface proteins to peptidoglycans of the bacterial cell wall envelope. They do so by catalyzing a transpeptidation reaction in which the...; Region: Sortase_A_1; cd06165
591365002867	active site
591365002868	catalytic site [active]
591365002869	pyridine nucleotide-disulfide oxidoreductase; Provisional; Region: PRK07251
591365002870	ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314
591365002871	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
591365002872	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
591365002873	Large-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscL; COG1970
591365002874	large-conductance mechanosensitive channel; Reviewed; Region: mscL; PRK00567
591365002875	DNA primase; Validated; Region: dnaG; PRK05667
591365002876	CHC2 zinc finger; Region: zf-CHC2; pfam01807
591365002877	DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275
591365002878	TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364
591365002879	active site
591365002880	metal binding site [ion binding]; metal-binding site
591365002881	interdomain interaction site; other site
591365002882	DnaB-helicase binding domain of primase; Region: DnaB_bind; pfam10410
591365002883	RNA polymerase sigma factor RpoD; Validated; Region: PRK09210
591365002884	Sigma-70 factor, region 1.1; Region: Sigma70_r1_1; pfam03979
591365002885	Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140
591365002886	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
591365002887	Sigma-70 region 3; Region: Sigma70_r3; pfam04539
591365002888	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
591365002889	DNA binding residues [nucleotide binding]
591365002890	Predicted metal-sulfur cluster biosynthetic enzyme [General function prediction only]; Region: PaaD; COG2151
591365002891	Branched-chain amino acid transport protein; Region: Branch_AA_trans; pfam05525
591365002892	Cytochrome c biogenesis protein [Posttranslational modification, protein turnover, chaperones]; Region: CcdA; COG0785
591365002893	Cytochrome C biogenesis protein transmembrane region; Region: DsbD; pfam02683
591365002894	TlpA-like family; composed of  TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966
591365002895	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
591365002896	catalytic residues [active]
591365002897	Peptide methionine sulfoxide reductase [Posttranslational modification, protein turnover, chaperones]; Region: MsrA; COG0225
591365002898	Conserved domain frequently associated with peptide methionine sulfoxide reductase [Posttranslational modification, protein turnover, chaperones]; Region: COG0229
591365002899	SelR domain; Region: SelR; pfam01641
591365002900	Response regulator receiver domain; Region: Response_reg; pfam00072
591365002901	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
591365002902	active site
591365002903	phosphorylation site [posttranslational modification]
591365002904	intermolecular recognition site; other site
591365002905	dimerization interface [polypeptide binding]; other site
591365002906	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
591365002907	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
591365002908	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
591365002909	Predicted signal transduction protein with a C-terminal ATPase domain [Signal transduction mechanisms]; Region: COG2972
591365002910	Cache domain; Region: Cache_1; pfam02743
591365002911	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
591365002912	dimerization interface [polypeptide binding]; other site
591365002913	Histidine kinase; Region: His_kinase; pfam06580
591365002914	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
591365002915	ATP binding site [chemical binding]; other site
591365002916	Mg2+ binding site [ion binding]; other site
591365002917	G-X-G motif; other site
591365002918	ABC-2 family transporter protein; Region: ABC2_membrane_6; cl01496
591365002919	ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4587
591365002920	ABC-2 family transporter protein; Region: ABC2_membrane_6; cl01496
591365002921	ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: COG4586
591365002922	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
591365002923	Walker A/P-loop; other site
591365002924	ATP binding site [chemical binding]; other site
591365002925	Q-loop/lid; other site
591365002926	ABC transporter signature motif; other site
591365002927	Walker B; other site
591365002928	D-loop; other site
591365002929	H-loop/switch region; other site
591365002930	Predicted flavoprotein [General function prediction only]; Region: COG0431
591365002931	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
591365002932	PAS domain; Region: PAS_10; pfam13596
591365002933	Predicted flavoprotein [General function prediction only]; Region: COG0431
591365002934	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
591365002935	Membrane-associated lipoprotein involved in thiamine biosynthesis [Coenzyme metabolism]; Region: ApbE; COG1477
591365002936	ApbE family; Region: ApbE; pfam02424
591365002937	coenzyme A disulfide reductase; Reviewed; Region: PRK09564
591365002938	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
591365002939	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
591365002940	Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038
591365002941	ClC chloride channel EriC.  This domain is found in the EriC chloride transporters that mediate the extreme acid resistance response in eubacteria and archaea. This response allows bacteria to survive in the acidic environments by decarboxylation-linked...; Region: EriC; cd01031
591365002942	Cl- selectivity filter; other site
591365002943	Cl- binding residues [ion binding]; other site
591365002944	pore gating glutamate residue; other site
591365002945	dimer interface [polypeptide binding]; other site
591365002946	H+/Cl- coupling transport residue; other site
591365002947	TrkA-C domain; Region: TrkA_C; pfam02080
591365002948	Protein of unknown function (DUF1266); Region: DUF1266; pfam06889
591365002949	guanosine 5'-monophosphate oxidoreductase; Provisional; Region: PRK05458
591365002950	IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381
591365002951	active site
591365002952	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
591365002953	active site
591365002954	xanthine permease; Region: pbuX; TIGR03173
591365002955	Sulfate transporter family; Region: Sulfate_transp; pfam00916
591365002956	Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326
591365002957	Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Vibrio cholerae NorM; Region: MATE_NorM_like; cd13131
591365002958	cation binding site [ion binding]; other site
591365002959	thymidine kinase; Provisional; Region: PRK04296
591365002960	peptide chain release factor 1; Validated; Region: prfA; PRK00591
591365002961	This domain is found in peptide chain release factors; Region: PCRF; smart00937
591365002962	RF-1 domain; Region: RF-1; pfam00472
591365002963	protein-(glutamine-N5) methyltransferase, release factor-specific; Region: RF_mod_PrmC; TIGR03534
591365002964	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
591365002965	S-adenosylmethionine binding site [chemical binding]; other site
591365002966	Putative translation factor (SUA5) [Translation, ribosomal structure and biogenesis]; Region: SUA5; COG0009
591365002967	serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011
591365002968	Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378
591365002969	dimer interface [polypeptide binding]; other site
591365002970	active site
591365002971	glycine-pyridoxal phosphate binding site [chemical binding]; other site
591365002972	folate binding site [chemical binding]; other site
591365002973	37-kD nucleoid-associated bacterial protein; Region: NA37; cl15473
591365002974	Lysozyme-like; Region: Lysozyme_like; pfam13702
591365002975	Alpha/beta hydrolase of unknown function (DUF915); Region: DUF915; pfam06028
591365002976	GMP synthase; Reviewed; Region: guaA; PRK00074
591365002977	Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742
591365002978	AMP/PPi binding site [chemical binding]; other site
591365002979	candidate oxyanion hole; other site
591365002980	catalytic triad [active]
591365002981	potential glutamine specificity residues [chemical binding]; other site
591365002982	The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997
591365002983	ATP Binding subdomain [chemical binding]; other site
591365002984	Dimerization subdomain; other site
591365002985	Transcriptional regulators [Transcription]; Region: PhnF; COG2188
591365002986	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
591365002987	DNA-binding site [nucleotide binding]; DNA binding site
591365002988	UTRA domain; Region: UTRA; pfam07702
591365002989	putative DNA-binding protein; Validated; Region: PRK00118
591365002990	Putative helix-turn-helix protein, YlxM / p13 like; Region: UPF0122; pfam04297
591365002991	signal recognition particle protein; Provisional; Region: PRK10867
591365002992	SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963
591365002993	The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115
591365002994	P loop; other site
591365002995	GTP binding site [chemical binding]; other site
591365002996	Signal peptide binding domain; Region: SRP_SPB; pfam02978
591365002997	site-specific tyrosine recombinase XerS; Reviewed; Region: xerS; PRK05084
591365002998	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
591365002999	active site
591365003000	DNA binding site [nucleotide binding]
591365003001	Int/Topo IB signature motif; other site
591365003002	ATP-grasp domain; Region: ATP-grasp_4; pfam13535
591365003003	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4947
591365003004	Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819
591365003005	Putative esterase; Region: Esterase; pfam00756
591365003006	tRNA (uracil-5-)-methyltransferase Gid; Reviewed; Region: PRK05335
591365003007	Glucose inhibited division protein A; Region: GIDA; pfam01134
591365003008	DNA topoisomerase I; Validated; Region: PRK05582
591365003009	TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I.   Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363
591365003010	active site
591365003011	interdomain interaction site; other site
591365003012	putative metal-binding site [ion binding]; other site
591365003013	nucleotide binding site [chemical binding]; other site
591365003014	DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186
591365003015	domain I; other site
591365003016	DNA binding groove [nucleotide binding]
591365003017	phosphate binding site [ion binding]; other site
591365003018	domain II; other site
591365003019	domain III; other site
591365003020	nucleotide binding site [chemical binding]; other site
591365003021	catalytic site [active]
591365003022	domain IV; other site
591365003023	Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396
591365003024	Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396
591365003025	DNA recombination-mediator protein A; Region: DNA_processg_A; pfam02481
591365003026	DNA protecting protein DprA; Region: dprA; TIGR00732
591365003027	maltose O-acetyltransferase; Provisional; Region: PRK10092
591365003028	Maltose O-acetyltransferase (MAT) and Galactoside O-acetyltransferase (GAT): MAT and GAT catalyze the CoA-dependent acetylation of the 6-hydroxyl group of their respective sugar substrates. MAT acetylates maltose and glucose exclusively at the C6...; Region: LbH_MAT_GAT; cd03357
591365003029	active site
591365003030	substrate binding site [chemical binding]; other site
591365003031	trimer interface [polypeptide binding]; other site
591365003032	CoA binding site [chemical binding]; other site
591365003033	bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182
591365003034	RNA/DNA hybrid binding site [nucleotide binding]; other site
591365003035	active site
591365003036	GTPase YlqF; Reviewed; Region: rbgA; PRK09563
591365003037	Circularly permuted YlqF GTPase; Region: YlqF; cd01856
591365003038	GTP/Mg2+ binding site [chemical binding]; other site
591365003039	G4 box; other site
591365003040	G5 box; other site
591365003041	Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170
591365003042	G1 box; other site
591365003043	G1 box; other site
591365003044	GTP/Mg2+ binding site [chemical binding]; other site
591365003045	Switch I region; other site
591365003046	G2 box; other site
591365003047	G2 box; other site
591365003048	G3 box; other site
591365003049	G3 box; other site
591365003050	Switch II region; other site
591365003051	Switch II region; other site
591365003052	G5 box; other site
591365003053	30S ribosomal protein S21; Reviewed; Region: rpsU; PRK00270
591365003054	ATP cone domain; Region: ATP-cone; pfam03477
591365003055	Cysteine-rich secretory protein family; Region: CAP; pfam00188
591365003056	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167
591365003057	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
591365003058	DNA-binding site [nucleotide binding]; DNA binding site
591365003059	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
591365003060	pyridoxal 5'-phosphate binding site [chemical binding]; other site
591365003061	homodimer interface [polypeptide binding]; other site
591365003062	catalytic residue [active]
591365003063	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
591365003064	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
591365003065	ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254
591365003066	Walker A/P-loop; other site
591365003067	ATP binding site [chemical binding]; other site
591365003068	Q-loop/lid; other site
591365003069	ABC transporter signature motif; other site
591365003070	Walker B; other site
591365003071	D-loop; other site
591365003072	H-loop/switch region; other site
591365003073	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
591365003074	putative multidrug transporter membrane\ATP-binding components; Provisional; Region: PRK10789
591365003075	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
591365003076	Walker A/P-loop; other site
591365003077	ATP binding site [chemical binding]; other site
591365003078	Q-loop/lid; other site
591365003079	ABC transporter signature motif; other site
591365003080	Walker B; other site
591365003081	D-loop; other site
591365003082	H-loop/switch region; other site
591365003083	Protein of unknown function (DUF419); Region: DUF419; cl15265
591365003084	Uncharacterized protein involved in copper resistance [Inorganic ion transport and metabolism]; Region: CutC; COG3142
591365003085	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
591365003086	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
591365003087	Predicted small molecule binding protein (contains 3H domain) [General function prediction only]; Region: COG1827
591365003088	HTH domain; Region: HTH_11; pfam08279
591365003089	3H domain; Region: 3H; pfam02829
591365003090	Ribosomal protein S16 [Translation, ribosomal structure and biogenesis]; Region: RpsP; COG0228
591365003091	Family 41 Carbohydrate-Binding Module from pullulanase-like enzymes; Region: CBM41_pullulanase; cd10315
591365003092	carbohydrate binding site [chemical binding]; other site
591365003093	pullulanase, type I; Region: pulA_typeI; TIGR02104
591365003094	Early set domain associated with the catalytic domain of pullulanase (also called dextrinase and alpha-dextrin endo-1,6-alpha glucosidase); Region: E_set_Pullulanase; cd02860
591365003095	Alpha amylase catalytic domain found in Pullulanase (also called dextrinase; alpha-dextrin endo-1,6-alpha glucosidase), limit dextrinase, and related proteins; Region: AmyAc_Pullulanase_LD-like; cd11341
591365003096	Ca binding site [ion binding]; other site
591365003097	active site
591365003098	catalytic site [active]
591365003099	putative lipid kinase; Reviewed; Region: PRK13055
591365003100	Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781
591365003101	NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956
591365003102	NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114
591365003103	nucleotide binding pocket [chemical binding]; other site
591365003104	K-X-D-G motif; other site
591365003105	catalytic site [active]
591365003106	NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120
591365003107	NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119
591365003108	Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027
591365003109	Dimer interface [polypeptide binding]; other site
591365003110	BRCT sequence motif; other site
591365003111	2-dehydropantoate 2-reductase; Reviewed; Region: PRK06522
591365003112	Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558
591365003113	Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546
591365003114	Predicted membrane protein, putative toxin regulator [General function prediction only]; Region: PfoR; COG3641
591365003115	Phosphotransferase system, EIIC; Region: PTS_EIIC_2; pfam13303
591365003116	Predicted membrane protein [Function unknown]; Region: COG4708
591365003117	Predicted membrane protein [Function unknown]; Region: COG2246
591365003118	GtrA-like protein; Region: GtrA; pfam04138
591365003119	Solo B3/4 domain (OB-fold DNA/RNA-binding) of Phe-aaRS-beta [General function prediction only]; Region: COG3382
591365003120	B3/4 domain; Region: B3_4; pfam03483
591365003121	Transcriptional regulators [Transcription]; Region: MarR; COG1846
591365003122	MarR family; Region: MarR; pfam01047
591365003123	Ribonuclease BN family enzyme [Replication, recombination, and repair]; Region: Rbn; COG1295
591365003124	Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086
591365003125	active site
591365003126	Predicted transcriptional regulator containing CBS domains [Transcription]; Region: COG4109
591365003127	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
591365003128	DNA-binding site [nucleotide binding]; DNA binding site
591365003129	DRTGG domain; Region: DRTGG; pfam07085
591365003130	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with a DRTGG domain upstream. The function of the DRTGG domain, named after its conserved residues, is unknown. CBS is a small domain originally...; Region: CBS_pair_DRTGG_assoc; cd04596
591365003131	The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cd03440
591365003132	active site 2 [active]
591365003133	active site 1 [active]
591365003134	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
591365003135	Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583
591365003136	UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072
591365003137	UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555
591365003138	hinge; other site
591365003139	active site
591365003140	S-adenosylmethionine synthetase; Validated; Region: PRK05250
591365003141	S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438
591365003142	S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772
591365003143	S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773
591365003144	dihydroorotase; Validated; Region: pyrC; PRK09357
591365003145	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
591365003146	Dihydroorotase (DHOase), subgroup IIa; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This subgroup also contains proteins that lack the active site, like unc-33, a C; Region: DHOase_IIa; cd01317
591365003147	active site
591365003148	MutT homolog-1 (MTH1) is a member of the Nudix hydrolase superfamily. MTH1, the mammalian counterpart of MutT, hydrolyzes oxidized purine nucleoside triphosphates, such as 8-oxo-dGTP and 2-hydroxy-ATP, to monophosphates, thereby preventing the...; Region: MTH1; cd03427
591365003149	putative active site [active]
591365003150	nucleotide binding site [chemical binding]; other site
591365003151	nudix motif; other site
591365003152	putative metal binding site [ion binding]; other site
591365003153	Family 1 of Uracil-DNA glycosylase (UDG) enzymes; Region: UDG_F1; cd10027
591365003154	ligand binding site [chemical binding]; other site
591365003155	active site
591365003156	UGI interface [polypeptide binding]; other site
591365003157	catalytic site [active]
591365003158	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
591365003159	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
591365003160	Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894
591365003161	Predicted membrane protein [Function unknown]; Region: COG3152
591365003162	Predicted membrane metal-binding protein [General function prediction only]; Region: ComEC; COG0658
591365003163	Domain of unknown function (DUF4131); Region: DUF4131; pfam13567
591365003164	Competence protein; Region: Competence; pfam03772
591365003165	Predicted hydrolase (metallo-beta-lactamase superfamily) [General function prediction only]; Region: ComEC; COG2333
591365003166	Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446
591365003167	SLBB domain; Region: SLBB; pfam10531
591365003168	comEA protein; Region: comE; TIGR01259
591365003169	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cl14786
591365003170	Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294
591365003171	SmpB-tmRNA interface; other site
591365003172	ribonuclease R; Region: RNase_R; TIGR02063
591365003173	Ribonuclease B OB domain; Region: OB_RNB; pfam08206
591365003174	RNB domain; Region: RNB; pfam00773
591365003175	S1_RNase_R: RNase R C-terminal S1 domain. RNase R is a processive 3' to 5' exoribonuclease, which is a homolog of RNase II. RNase R degrades RNA with secondary structure having a 3' overhang of at least 7 nucleotides. RNase R and PNPase...; Region: S1_RNase_R; cd04471
591365003176	RNA binding site [nucleotide binding]; other site
591365003177	Preprotein translocase subunit SecG [Intracellular trafficking and secretion]; Region: SecG; COG1314
591365003178	drug efflux system protein MdtG; Provisional; Region: PRK09874
591365003179	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
591365003180	putative substrate translocation pore; other site
591365003181	Dephospho-CoA kinase [Coenzyme metabolism]; Region: CoaE; COG0237
591365003182	Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022
591365003183	CoA-binding site [chemical binding]; other site
591365003184	ATP-binding [chemical binding]; other site
591365003185	formamidopyrimidine/5-formyluracil/ 5-hydroxymethyluracil DNA glycosylase; Validated; Region: PRK01103
591365003186	N-terminal domain of Escherichia coli Fpg1/MutM and related bacterial DNA glycosylases; Region: EcFpg-like_N; cd08966
591365003187	DNA binding site [nucleotide binding]
591365003188	catalytic residue [active]
591365003189	H2TH interface [polypeptide binding]; other site
591365003190	putative catalytic residues [active]
591365003191	turnover-facilitating residue; other site
591365003192	intercalation triad [nucleotide binding]; other site
591365003193	8OG recognition residue [nucleotide binding]; other site
591365003194	putative reading head residues; other site
591365003195	Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831
591365003196	Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827
591365003197	Acetyltransferases [General function prediction only]; Region: RimI; COG0456
591365003198	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
591365003199	Coenzyme A binding pocket [chemical binding]; other site
591365003200	DinB superfamily; Region: DinB_2; pfam12867
591365003201	Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670
591365003202	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
591365003203	Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_18; cd04677
591365003204	nudix motif; other site
591365003205	GTPase Era; Reviewed; Region: era; PRK00089
591365003206	E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163
591365003207	G1 box; other site
591365003208	GTP/Mg2+ binding site [chemical binding]; other site
591365003209	Switch I region; other site
591365003210	G2 box; other site
591365003211	Switch II region; other site
591365003212	G3 box; other site
591365003213	G4 box; other site
591365003214	G5 box; other site
591365003215	KH domain; Region: KH_2; pfam07650
591365003216	Diacylglycerol kinase [Cell envelope biogenesis, outer membrane]; Region: DgkA; COG0818
591365003217	metal-binding heat shock protein; Provisional; Region: PRK00016
591365003218	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
591365003219	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
591365003220	ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254
591365003221	Walker A/P-loop; other site
591365003222	ATP binding site [chemical binding]; other site
591365003223	Q-loop/lid; other site
591365003224	ABC transporter signature motif; other site
591365003225	Walker B; other site
591365003226	D-loop; other site
591365003227	H-loop/switch region; other site
591365003228	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
591365003229	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
591365003230	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
591365003231	Walker A/P-loop; other site
591365003232	ATP binding site [chemical binding]; other site
591365003233	Q-loop/lid; other site
591365003234	ABC transporter signature motif; other site
591365003235	Walker B; other site
591365003236	D-loop; other site
591365003237	H-loop/switch region; other site
591365003238	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
591365003239	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
591365003240	Coenzyme A binding pocket [chemical binding]; other site
591365003241	Alanine dehydrogenase [Amino acid transport and metabolism]; Region: Ald; COG0686
591365003242	Alanine dehydrogenase NAD-binding and catalytic domains; Region: L-AlaDH; cd05305
591365003243	hexamer interface [polypeptide binding]; other site
591365003244	ligand binding site [chemical binding]; other site
591365003245	putative active site [active]
591365003246	NAD(P) binding site [chemical binding]; other site
591365003247	Regulator of competence-specific genes [Transcription]; Region: TfoX; COG3070
591365003248	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
591365003249	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
591365003250	Coenzyme A binding pocket [chemical binding]; other site
591365003251	Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702
591365003252	PhoH-like protein; Region: PhoH; pfam02562
591365003253	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
591365003254	active site
591365003255	Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725
591365003256	active site
591365003257	dimer interface [polypeptide binding]; other site
591365003258	dihydroorotate dehydrogenase (subfamily 1) family protein; Region: pyrD_sub1_fam; TIGR01037
591365003259	Dihydroorotate dehydrogenase (DHOD) class 1B FMN-binding domain. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine...; Region: DHOD_1B_like; cd04740
591365003260	heterodimer interface [polypeptide binding]; other site
591365003261	active site
591365003262	FMN binding site [chemical binding]; other site
591365003263	homodimer interface [polypeptide binding]; other site
591365003264	substrate binding site [chemical binding]; other site
591365003265	dihydroorotate dehydrogenase electron transfer subunit; Reviewed; Region: PRK00054
591365003266	FAD/NAD binding domain in the electron transfer subunit of dihydroorotate dehydrogenase. Dihydroorotate dehydrogenases (DHODs) catalyze the only redox reaction in pyrimidine de novo biosynthesis. They catalyze the oxidation of (S)-dihydroorotate to...; Region: DHOD_e_trans; cd06218
591365003267	FAD binding pocket [chemical binding]; other site
591365003268	FAD binding motif [chemical binding]; other site
591365003269	phosphate binding motif [ion binding]; other site
591365003270	beta-alpha-beta structure motif; other site
591365003271	NAD binding pocket [chemical binding]; other site
591365003272	Iron coordination center [ion binding]; other site
591365003273	Transcriptional regulator [Transcription]; Region: LysR; COG0583
591365003274	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
591365003275	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
591365003276	dimerization interface [polypeptide binding]; other site
591365003277	benzoate transport; Region: 2A0115; TIGR00895
591365003278	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
591365003279	putative substrate translocation pore; other site
591365003280	Alpha/beta hydrolase of unknown function (DUF915); Region: DUF915; pfam06028
591365003281	Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; cl17295
591365003282	homoserine kinase; Provisional; Region: PRK01212
591365003283	GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288
591365003284	GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544
591365003285	homoserine dehydrogenase; Provisional; Region: PRK06349
591365003286	Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447
591365003287	Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742
591365003288	ACT_HSDH_Hom CD includes the C-terminal ACT domain of the NAD(P)H-dependent, homoserine dehydrogenase (HSDH) and related domains; Region: ACT_HSDH-Hom; cd04881
591365003289	Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726
591365003290	Putative catalytic NodB homology domain of PgaB, IcaB, and similar proteins which consist of a deformed (beta/alpha)8 barrel fold with 5- or 6-strands; Region: CE4_NodB_like_5s_6s; cd10918
591365003291	putative active site [active]
591365003292	putative metal binding site [ion binding]; other site
591365003293	GTPase CgtA; Reviewed; Region: obgE; PRK12297
591365003294	GTP1/OBG; Region: GTP1_OBG; pfam01018
591365003295	Obg GTPase; Region: Obg; cd01898
591365003296	G1 box; other site
591365003297	GTP/Mg2+ binding site [chemical binding]; other site
591365003298	Switch I region; other site
591365003299	G2 box; other site
591365003300	G3 box; other site
591365003301	Switch II region; other site
591365003302	G4 box; other site
591365003303	G5 box; other site
591365003304	Domain of unknown function (DUF1967); Region: DUF1967; pfam09269
591365003305	galactose-1-phosphate uridylyltransferase; Provisional; Region: PRK05270
591365003306	Galactose-1-phosphate uridyl transferase, N-terminal domain; Region: GalP_UDP_transf; pfam01087
591365003307	Galactose-1-phosphate uridyl transferase, C-terminal domain; Region: GalP_UDP_tr_C; pfam02744
591365003308	galactokinase; Provisional; Region: PRK05322
591365003309	Galactokinase galactose-binding signature; Region: GalKase_gal_bdg; pfam10509
591365003310	GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544
591365003311	DNA-binding transcriptional repressor EbgR; Provisional; Region: PRK10339
591365003312	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
591365003313	DNA binding site [nucleotide binding]
591365003314	Ligand-binding domain of DNA transcription repressor GalR which is one of two regulatory proteins involved in galactose transport and metabolism; Region: PBP1_GalR; cd01544
591365003315	putative ligand binding site [chemical binding]; other site
591365003316	putative dimerization interface [polypeptide binding]; other site
591365003317	bifunctional biotin--[acetyl-CoA-carboxylase] synthetase/biotin operon repressor; Provisional; Region: PRK11886
591365003318	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
591365003319	DNA-binding site [nucleotide binding]; DNA binding site
591365003320	Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; pfam03099
591365003321	Biotin protein ligase C terminal domain; Region: BPL_C; pfam02237
591365003322	Predicted membrane protein [Function unknown]; Region: COG2860
591365003323	UPF0126 domain; Region: UPF0126; pfam03458
591365003324	UPF0126 domain; Region: UPF0126; pfam03458
591365003325	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2964
591365003326	YheO-like PAS domain; Region: PAS_6; pfam08348
591365003327	HTH domain; Region: HTH_22; pfam13309
591365003328	dipeptidase PepV; Reviewed; Region: PRK07318
591365003329	M20 Peptidase Xaa-His dipeptidase (PepV) degrades hydrophobic dipeptides; Region: M20_PepV; cd03888
591365003330	active site
591365003331	metal binding site [ion binding]; metal-binding site
591365003332	Cystathionine beta-lyases/cystathionine gamma-synthases [Amino acid transport and metabolism]; Region: MetC; COG0626
591365003333	CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614
591365003334	homodimer interface [polypeptide binding]; other site
591365003335	substrate-cofactor binding pocket; other site
591365003336	pyridoxal 5'-phosphate binding site [chemical binding]; other site
591365003337	catalytic residue [active]
591365003338	Amino acid permease; Region: AA_permease; pfam00324
591365003339	Predicted glutamine amidotransferases [General function prediction only]; Region: COG2071
591365003340	Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_2; cd01745
591365003341	catalytic triad [active]
591365003342	GAF domain-containing protein [Signal transduction mechanisms]; Region: COG1956
591365003343	GAF domain; Region: GAF_2; pfam13185
591365003344	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
591365003345	S-adenosylmethionine binding site [chemical binding]; other site
591365003346	SAP domain; Region: SAP; cl02640
591365003347	streptococcal histidine triad protein; Region: strep_his_triad; TIGR01363
591365003348	Streptococcal histidine triad protein; Region: Strep_his_triad; pfam04270
591365003349	Streptococcal histidine triad protein; Region: Strep_his_triad; pfam04270
591365003350	Streptococcal histidine triad protein; Region: Strep_his_triad; pfam04270
591365003351	ABC-type metal ion transport system, periplasmic component/surface adhesin [Inorganic ion transport and metabolism]; Region: LraI; COG0803
591365003352	Metal binding protein AcdA.  These proteins have been shown to function in the ABC uptake of Zn2+ and Mn2+ and in competence for genetic transformation and adhesion. The AcdA proteins belong to the TroA superfamily of helical backbone metal receptor...; Region: AdcA; cd01017
591365003353	metal binding site [ion binding]; metal-binding site
591365003354	tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026
591365003355	16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK00122
591365003356	RimM N-terminal domain; Region: RimM; pfam01782
591365003357	PRC-barrel domain; Region: PRC; pfam05239
591365003358	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
591365003359	ATP-binding cassette domain of multidrug resistance protein-like transporters; Region: ABCC_MRP_Like; cd03228
591365003360	Walker A/P-loop; other site
591365003361	ATP binding site [chemical binding]; other site
591365003362	Q-loop/lid; other site
591365003363	ABC transporter signature motif; other site
591365003364	Walker B; other site
591365003365	D-loop; other site
591365003366	H-loop/switch region; other site
591365003367	Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387
591365003368	core dimer interface [polypeptide binding]; other site
591365003369	L10 interface [polypeptide binding]; other site
591365003370	L11 interface [polypeptide binding]; other site
591365003371	putative EF-Tu interaction site [polypeptide binding]; other site
591365003372	putative EF-G interaction site [polypeptide binding]; other site
591365003373	Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797
591365003374	23S rRNA interface [nucleotide binding]; other site
591365003375	Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site
591365003376	Helix-turn-helix domain; Region: HTH_18; pfam12833
591365003377	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
591365003378	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3708
591365003379	A predicted NlpC/p60-like peptidase; Region: BtrH; pfam14399
591365003380	Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various bacteriocins (mostly non-lantibiotic); Region: Peptidase_C39_like; cl00296
591365003381	putative active site [active]
591365003382	Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950
591365003383	Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329
591365003384	dimer interface [polypeptide binding]; other site
591365003385	active site
591365003386	catalytic residue [active]
591365003387	aspartate-semialdehyde dehydrogenase; Provisional; Region: PRK14874
591365003388	Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859
591365003389	Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687
591365003390	Bacterial extracellular solute-binding protein; Region: SBP_bac_6; pfam13343
591365003391	ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177
591365003392	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
591365003393	dimer interface [polypeptide binding]; other site
591365003394	conserved gate region; other site
591365003395	putative PBP binding loops; other site
591365003396	ABC-ATPase subunit interface; other site
591365003397	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
591365003398	dimer interface [polypeptide binding]; other site
591365003399	conserved gate region; other site
591365003400	putative PBP binding loops; other site
591365003401	ABC-ATPase subunit interface; other site
591365003402	ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842
591365003403	ATP-binding cassette domain of the polyamine transporter; Region: ABC_PotA_N; cd03300
591365003404	Walker A/P-loop; other site
591365003405	ATP binding site [chemical binding]; other site
591365003406	Q-loop/lid; other site
591365003407	ABC transporter signature motif; other site
591365003408	Walker B; other site
591365003409	D-loop; other site
591365003410	H-loop/switch region; other site
591365003411	TOBE domain; Region: TOBE_2; pfam08402
591365003412	UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK13905
591365003413	FAD binding domain; Region: FAD_binding_4; pfam01565
591365003414	UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873
591365003415	GTP-binding protein LepA; Provisional; Region: PRK05433
591365003416	LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890
591365003417	G1 box; other site
591365003418	putative GEF interaction site [polypeptide binding]; other site
591365003419	GTP/Mg2+ binding site [chemical binding]; other site
591365003420	Switch I region; other site
591365003421	G2 box; other site
591365003422	G3 box; other site
591365003423	Switch II region; other site
591365003424	G4 box; other site
591365003425	G5 box; other site
591365003426	lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699
591365003427	lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane.   LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709
591365003428	GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421
591365003429	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
591365003430	haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282
591365003431	active site
591365003432	motif I; other site
591365003433	motif II; other site
591365003434	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
591365003435	motif II; other site
591365003436	Protoheme ferro-lyase (ferrochelatase) [Coenzyme metabolism]; Region: HemH; COG0276
591365003437	Class II Chelatase: a family of ATP-independent monomeric or homodimeric enzymes that catalyze the insertion of metal into protoporphyrin rings. This family includes protoporphyrin IX ferrochelatase (HemH), sirohydrochlorin ferrochelatase (SirB) and the...; Region: Chelatase_Class_II; cl02784
591365003438	active site
591365003439	Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419
591365003440	active site
591365003441	N-terminal domain interface [polypeptide binding]; other site
591365003442	peptidase T; Region: peptidase-T; TIGR01882
591365003443	M20 Peptidase T specifically cleaves tripeptides; Region: M20_peptT; cd03892
591365003444	metal binding site [ion binding]; metal-binding site
591365003445	dimer interface [polypeptide binding]; other site
591365003446	Uridine kinase [Nucleotide transport and metabolism]; Region: Udk; COG0572
591365003447	Uridine monophosphate kinase (UMPK, EC 2.7.1.48), also known as uridine kinase or uridine-cytidine kinase (UCK), catalyzes the reversible phosphoryl transfer from ATP to uridine or cytidine to yield UMP or CMP. In the primidine nucleotide-salvage pathway; Region: UMPK; cd02023
591365003448	Sugar specificity; other site
591365003449	Pyrimidine base specificity; other site
591365003450	ATP-binding site [chemical binding]; other site
591365003451	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
591365003452	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
591365003453	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251
591365003454	DEAD-like helicases superfamily; Region: DEXDc; smart00487
591365003455	ATP binding site [chemical binding]; other site
591365003456	putative Mg++ binding site [ion binding]; other site
591365003457	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
591365003458	nucleotide binding region [chemical binding]; other site
591365003459	ATP-binding site [chemical binding]; other site
591365003460	Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726
591365003461	Catalytic NodB homology domain of Streptococcus pneumoniae peptidoglycan deacetylase PgdA, Bacillus subtilis BsYjeA protein, and their bacterial homologs; Region: CE4_SpPgdA_BsYjeA_like; cd10947
591365003462	NodB motif; other site
591365003463	active site
591365003464	catalytic site [active]
591365003465	Zn binding site [ion binding]; other site
591365003466	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
591365003467	Glyoxalase I catalyzes the isomerization of the hemithioacetal, formed by a 2-oxoaldehyde and glutathione, to S-D-lactoylglutathione; Region: Glyoxalase_I; cd07233
591365003468	dimer interface [polypeptide binding]; other site
591365003469	active site
591365003470	metal binding site [ion binding]; metal-binding site
591365003471	glutathione binding site [chemical binding]; other site
591365003472	Ribosomal protein L20; Region: Ribosomal_L20; cd07026
591365003473	23S rRNA binding site [nucleotide binding]; other site
591365003474	L21 binding site [polypeptide binding]; other site
591365003475	L13 binding site [polypeptide binding]; other site
591365003476	50S ribosomal protein L35; Reviewed; Region: rpmI; PRK00172
591365003477	translation initiation factor IF-3; Reviewed; Region: infC; PRK00028
591365003478	Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198
591365003479	Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707
591365003480	cytidylate kinase; Provisional; Region: cmk; PRK00023
591365003481	Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020
591365003482	CMP-binding site; other site
591365003483	The sites determining sugar specificity; other site
591365003484	glycerate kinase; Region: TIGR00045
591365003485	phosphoserine phosphatase SerB; Region: serB; TIGR00338
591365003486	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
591365003487	motif II; other site
591365003488	phosphoglucosamine mutase; Provisional; Region: glmM; PRK14316
591365003489	GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802
591365003490	active site
591365003491	substrate binding site [chemical binding]; other site
591365003492	metal binding site [ion binding]; metal-binding site
591365003493	YbbR-like protein; Region: YbbR; pfam07949
591365003494	YbbR-like protein; Region: YbbR; pfam07949
591365003495	TIGR00159 family protein; Region: TIGR00159
591365003496	DisA bacterial checkpoint controller nucleotide-binding; Region: DisA_N; pfam02457
591365003497	UDP-N-acetylmuramyl tripeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurE; COG0769
591365003498	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
591365003499	Domain of unknown function (DUF1727); Region: DUF1727; pfam08353
591365003500	Type 1 glutamine amidotransferase (GATase1) domain found in Cobyric Acid Synthase (CobQ); Region: GATase1_CobQ; cd01750
591365003501	catalytic triad [active]
591365003502	ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488
591365003503	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
591365003504	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
591365003505	ABC transporter; Region: ABC_tran_2; pfam12848
591365003506	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
591365003507	Zinc-dependent metalloprotease, MMP_like subfamily. This group contains matrix metalloproteinases (MMPs), serralysins, and the astacin_like family of proteases; Region: ZnMc_MMP_like; cd04268
591365003508	active site
591365003509	Predicted esterase [General function prediction only]; Region: COG0627
591365003510	S-formylglutathione hydrolase; Region: PLN02442
591365003511	mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595
591365003512	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
591365003513	RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521
591365003514	Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826
591365003515	Peptidase family U32; Region: Peptidase_U32; pfam01136
591365003516	Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826
591365003517	Peptidase family U32; Region: Peptidase_U32; pfam01136
591365003518	Protein of unknown function (DUF3270); Region: DUF3270; pfam11674
591365003519	YtxH-like protein; Region: YtxH; pfam12732
591365003520	Uncharacterized protein containing a divergent version of the methyl-accepting chemotaxis-like domain [General function prediction only]; Region: COG4768
591365003521	Prolipoprotein diacylglyceryl transferase; Region: LGT; pfam01790
591365003522	HPr kinase/phosphorylase; Provisional; Region: PRK05428
591365003523	HPr Serine kinase N terminus; Region: Hpr_kinase_N; pfam02603
591365003524	HprK/P, the bifunctional histidine-containing protein kinase/phosphatase, controls the phosphorylation state of the phosphocarrier protein HPr and regulates the utilization of carbon sources by gram-positive bacteria. It catalyzes both the ATP-dependent...; Region: HprK_C; cd01918
591365003525	Hpr binding site; other site
591365003526	active site
591365003527	homohexamer subunit interaction site [polypeptide binding]; other site
591365003528	Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447
591365003529	nudix motif; other site
591365003530	hypothetical protein; Provisional; Region: PRK04351
591365003531	SprT homologues; Region: SprT; cl01182
591365003532	Transcriptional accessory protein [Transcription]; Region: Tex; COG2183
591365003533	Tex-like protein N-terminal domain; Region: Tex_N; pfam09371
591365003534	Likely ribonuclease with RNase H fold; Region: YqgFc; smart00732
591365003535	S1_Tex: The C-terminal S1 domain of a transcription accessory factor called Tex, which has been characterized in Bordetella pertussis and Pseudomonas aeruginosa. The tex gene is essential in Bortella pertusis and is named for its role in toxin expression; Region: S1_Tex; cd05685
591365003536	RNA binding site [nucleotide binding]; other site
591365003537	Predicted permeases [General function prediction only]; Region: COG0701
591365003538	Predicted membrane protein [Function unknown]; Region: COG3689
591365003539	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
591365003540	Major Facilitator Superfamily; Region: MFS_1; pfam07690
591365003541	putative substrate translocation pore; other site
591365003542	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
591365003543	glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722
591365003544	Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479
591365003545	Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781
591365003546	Protein of unknown function (DUF1275); Region: DUF1275; pfam06912
591365003547	DNA alkylation repair enzyme; Region: DNA_alkylation; pfam08713
591365003548	A new structural DNA glycosylase containing HEAT-like repeats; Region: AlkD_like_1; cd07064
591365003549	active site
591365003550	formate--tetrahydrofolate ligase; Provisional; Region: PRK13505
591365003551	Formyltetrahydrofolate synthetase (FTHFS) catalyzes the ATP-dependent activation of formate ion via its addition to the N10 position of tetrahydrofolate. FTHFS is a highly expressed key enzyme in both the Wood-Ljungdahl pathway of autotrophic CO2...; Region: FTHFS; cd00477
591365003552	Potassium binding sites [ion binding]; other site
591365003553	Cesium cation binding sites [ion binding]; other site
591365003554	phosphopantothenate--cysteine ligase; Validated; Region: PRK06732
591365003555	phosphopantothenoylcysteine decarboxylase; Validated; Region: PRK07313
591365003556	Flavoprotein; Region: Flavoprotein; pfam02441
591365003557	Predicted membrane protein [Function unknown]; Region: COG4684
591365003558	Protein of unknown function (DUF3816); Region: DUF3816; pfam12822
591365003559	This CD includes PGM2 (phosphoglucomutase 2) and PGM2L1 (phosphoglucomutase 2-like 1). The mammalian PGM2 is thought to be a phosphopentomutase that catalyzes the conversion of the nucleoside breakdown products, ribose-1-phosphate and...; Region: PGM2; cd05799
591365003560	Phosphomannomutase [Carbohydrate transport and metabolism]; Region: {ManB}; COG1109
591365003561	active site
591365003562	substrate binding site [chemical binding]; other site
591365003563	metal binding site [ion binding]; metal-binding site
591365003564	TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947
591365003565	catalytic residues [active]
591365003566	A/G-specific DNA glycosylase [DNA replication, recombination, and repair]; Region: MutY; COG1194
591365003567	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056
591365003568	minor groove reading motif; other site
591365003569	helix-hairpin-helix signature motif; other site
591365003570	substrate binding pocket [chemical binding]; other site
591365003571	active site
591365003572	DNA glycosylase (MutY in bacteria and hMYH in humans) is responsible for repairing misread  A*oxoG residues to C*G by removing the inappropriately paired adenine base from the DNA backbone. It belongs to the Nudix hydrolase superfamily and is important...; Region: DNA_Glycosylase_C; cd03431
591365003573	DNA binding and oxoG recognition site [nucleotide binding]
591365003574	phosphotransacetylase; Reviewed; Region: eutD; PRK09653
591365003575	Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564
591365003576	Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869
591365003577	active site
591365003578	inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK04885
591365003579	ATP-NAD kinase; Region: NAD_kinase; pfam01513
591365003580	Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399
591365003581	synthetase active site [active]
591365003582	NTP binding site [chemical binding]; other site
591365003583	metal binding site [ion binding]; metal-binding site
591365003584	Uncharacterized subgroup 1 of the CYTH-like superfamily; Region: CYTH-like_Pase_1; cd07762
591365003585	putative active site [active]
591365003586	putative metal binding residues [ion binding]; other site
591365003587	signature motif; other site
591365003588	putative triphosphate binding site [ion binding]; other site
591365003589	ribose-phosphate pyrophosphokinase; Provisional; Region: PRK02458
591365003590	N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793
591365003591	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
591365003592	active site
591365003593	Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104
591365003594	cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402
591365003595	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
591365003596	catalytic residue [active]
591365003597	Putative amino acid metabolism; Region: DUF1831; pfam08866
591365003598	redox-sensing transcriptional repressor Rex; Provisional; Region: PRK05472
591365003599	Putative DNA-binding protein N-terminus; Region: Put_DNA-bind_N; pfam06971
591365003600	CoA binding domain; Region: CoA_binding; pfam02629
591365003601	hypothetical protein; Reviewed; Region: PRK00024
591365003602	Nucleoporin autopeptidase; Region: Nucleoporin2; pfam04096
591365003603	Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071
591365003604	MPN+ (JAMM) motif; other site
591365003605	Zinc-binding site [ion binding]; other site
591365003606	phosphate transport system regulatory protein PhoU; Region: phoU_full; TIGR02135
591365003607	PhoU domain; Region: PhoU; pfam01895
591365003608	PhoU domain; Region: PhoU; pfam01895
591365003609	phosphate transporter ATP-binding protein; Provisional; Region: PRK14239
591365003610	ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260
591365003611	Walker A/P-loop; other site
591365003612	ATP binding site [chemical binding]; other site
591365003613	Q-loop/lid; other site
591365003614	ABC transporter signature motif; other site
591365003615	Walker B; other site
591365003616	D-loop; other site
591365003617	H-loop/switch region; other site
591365003618	phosphate transporter ATP-binding protein; Provisional; Region: PRK14237
591365003619	ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260
591365003620	Walker A/P-loop; other site
591365003621	ATP binding site [chemical binding]; other site
591365003622	Q-loop/lid; other site
591365003623	ABC transporter signature motif; other site
591365003624	Walker B; other site
591365003625	D-loop; other site
591365003626	H-loop/switch region; other site
591365003627	ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstA; COG0581
591365003628	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
591365003629	dimer interface [polypeptide binding]; other site
591365003630	conserved gate region; other site
591365003631	putative PBP binding loops; other site
591365003632	ABC-ATPase subunit interface; other site
591365003633	ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstC; COG0573
591365003634	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
591365003635	dimer interface [polypeptide binding]; other site
591365003636	conserved gate region; other site
591365003637	putative PBP binding loops; other site
591365003638	ABC-ATPase subunit interface; other site
591365003639	PBP superfamily domain; Region: PBP_like_2; cl17296
591365003640	rRNA (cytosine-C(5)-)-methyltransferase RsmF; Reviewed; Region: yebU; PRK11933
591365003641	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
591365003642	S-adenosylmethionine binding site [chemical binding]; other site
591365003643	pre-rRNA processing and ribosome biogenesis; Region: Nol1_Nop2_Fmu_2; pfam13636
591365003644	Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483
591365003645	Inositol-monophosphatase-like domains. This family of phosphatases is dependent on bivalent metal ions such as Mg++, and many members are inhibited by Li+ (which is thought to displace a bivalent ion in the active site). Substrates include fructose-1; Region: IMPase_like; cd01637
591365003646	active site
591365003647	hypothetical protein; Provisional; Region: PRK04387
591365003648	Arsenate Reductase (ArsC) family, Spx subfamily; Spx is a unique RNA polymerase (RNAP)-binding protein present in bacilli and some mollicutes. It inhibits transcription by binding to the C-terminal domain of the alpha subunit of RNAP, disrupting complex...; Region: ArsC_Spx; cd03032
591365003649	ArsC family; Region: ArsC; pfam03960
591365003650	putative catalytic residues [active]
591365003651	thiol/disulfide switch; other site
591365003652	bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627
591365003653	FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064
591365003654	active site
591365003655	Riboflavin kinase; Region: Flavokinase; smart00904
591365003656	tRNA pseudouridine synthase B; Provisional; Region: truB; PRK02484
591365003657	Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573
591365003658	RNA binding site [nucleotide binding]; other site
591365003659	active site
591365003660	tRNA Pseudouridine synthase II, C terminal; Region: TruB_C; pfam09142
591365003661	alpha/beta hydrolase fold; Region: Abhydrolase_1; pfam00561
591365003662	homoserine O-acetyltransferase; Provisional; Region: metX; cl17114
591365003663	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4487
591365003664	Uncharacterized protein conserved in bacteria (DUF2130); Region: DUF2130; pfam09903
591365003665	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
591365003666	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
591365003667	Predicted transcriptional regulators [Transcription]; Region: COG1510
591365003668	MarR family; Region: MarR_2; cl17246
591365003669	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
591365003670	PTS system sugar-specific permease component; Region: EIIC-GAT; cl04451
591365003671	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
591365003672	ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251
591365003673	Walker A/P-loop; other site
591365003674	ATP binding site [chemical binding]; other site
591365003675	Q-loop/lid; other site
591365003676	ABC transporter signature motif; other site
591365003677	Walker B; other site
591365003678	D-loop; other site
591365003679	H-loop/switch region; other site
591365003680	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
591365003681	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
591365003682	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
591365003683	Walker A/P-loop; other site
591365003684	ATP binding site [chemical binding]; other site
591365003685	Q-loop/lid; other site
591365003686	ABC transporter signature motif; other site
591365003687	Walker B; other site
591365003688	D-loop; other site
591365003689	H-loop/switch region; other site
591365003690	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
591365003691	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
591365003692	Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447
591365003693	nudix motif; other site
591365003694	ATP-dependent DNA helicase PcrA; Region: pcrA; TIGR01073
591365003695	Part of AAA domain; Region: AAA_19; pfam13245
591365003696	Family description; Region: UvrD_C_2; pfam13538
591365003697	Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053
591365003698	Cation efflux family; Region: Cation_efflux; pfam01545
591365003699	signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227
591365003700	The S24, S26 LexA/signal peptidase superfamily contains LexA-related and type I signal peptidase families. The S24 LexA protein domains include: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC 3.4.21.88), the...; Region: Peptidase_S24_S26; cl10465
591365003701	The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530
591365003702	pyruvate kinase; Provisional; Region: PRK05826
591365003703	Pyruvate kinase (PK):  Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342
591365003704	domain interfaces; other site
591365003705	active site
591365003706	Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to a subfamily of the PFKA family (cd00363) and include bacterial ATP-dependent...; Region: Bacterial_PFK; cd00763
591365003707	6-phosphofructokinase; Region: PFKA_ATP; TIGR02482
591365003708	active site
591365003709	ADP/pyrophosphate binding site [chemical binding]; other site
591365003710	dimerization interface [polypeptide binding]; other site
591365003711	allosteric effector site; other site
591365003712	fructose-1,6-bisphosphate binding site; other site
591365003713	DNA polymerase III DnaE; Reviewed; Region: dnaE; PRK07279
591365003714	Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III; Region: PHP_PolIIIA; cd07431
591365003715	active site
591365003716	PHP Thumb interface [polypeptide binding]; other site
591365003717	DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485
591365003718	generic binding surface II; other site
591365003719	generic binding surface I; other site
591365003720	single-stranded-DNA-specific exonuclease RecJ; Region: recJ; TIGR00644
591365003721	DHH family; Region: DHH; pfam01368
591365003722	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4199
591365003723	Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673
591365003724	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
591365003725	Coenzyme A binding pocket [chemical binding]; other site
591365003726	potential frameshift: common BLAST hit: gi|387783936|ref|YP_006070019.1| protein smtA
591365003727	Methyltransferase domain; Region: Methyltransf_23; pfam13489
591365003728	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
591365003729	S-adenosylmethionine binding site [chemical binding]; other site
591365003730	Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300
591365003731	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
591365003732	NAD(P) binding site [chemical binding]; other site
591365003733	active site
591365003734	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
591365003735	catalytic core [active]
591365003736	ribonuclease Z; Region: RNase_Z; TIGR02651
591365003737	Galactose-1-phosphate uridyl transferase, N-terminal domain; Region: GalP_UDP_transf; pfam01087
591365003738	GTPases [General function prediction only]; Region: HflX; COG2262
591365003739	GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167
591365003740	HflX GTPase family; Region: HflX; cd01878
591365003741	G1 box; other site
591365003742	GTP/Mg2+ binding site [chemical binding]; other site
591365003743	Switch I region; other site
591365003744	G2 box; other site
591365003745	G3 box; other site
591365003746	Switch II region; other site
591365003747	G4 box; other site
591365003748	G5 box; other site
591365003749	tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091
591365003750	tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324
591365003751	glutathione reductase; Validated; Region: PRK06116
591365003752	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
591365003753	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
591365003754	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
591365003755	Uncharacterized conserved protein [General function prediction only]; Region: BioY; COG1268
591365003756	phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629
591365003757	tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain.  PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796
591365003758	putative tRNA-binding site [nucleotide binding]; other site
591365003759	B3/4 domain; Region: B3_4; pfam03483
591365003760	tRNA synthetase B5 domain; Region: B5; smart00874
591365003761	Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA,  PheRS is an...; Region: PheRS_beta_core; cd00769
591365003762	dimer interface [polypeptide binding]; other site
591365003763	motif 1; other site
591365003764	motif 3; other site
591365003765	motif 2; other site
591365003766	Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; pfam03147
591365003767	Acetyltransferases [General function prediction only]; Region: RimI; COG0456
591365003768	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
591365003769	Coenzyme A binding pocket [chemical binding]; other site
591365003770	phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488
591365003771	Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912
591365003772	Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496
591365003773	dimer interface [polypeptide binding]; other site
591365003774	motif 1; other site
591365003775	active site
591365003776	motif 2; other site
591365003777	motif 3; other site
591365003778	ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488
591365003779	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
591365003780	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
591365003781	ABC transporter; Region: ABC_tran_2; pfam12848
591365003782	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
591365003783	tRNA CCA-pyrophosphorylase; Provisional; Region: PRK13299
591365003784	Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398
591365003785	active site
591365003786	NTP binding site [chemical binding]; other site
591365003787	metal binding triad [ion binding]; metal-binding site
591365003788	Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627
591365003789	tRNA nucleotidyltransferase domain 2 putative; Region: tRNA_NucTran2_2; pfam13735
591365003790	dihydrodipicolinate reductase; Provisional; Region: PRK00048
591365003791	Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113
591365003792	Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173
591365003793	EDD domain protein, DegV family; Region: DegV; TIGR00762
591365003794	Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645
591365003795	Protein of unknown function (DUF1149); Region: DUF1149; pfam06619
591365003796	PTS system 2-O-a-mannosyl-D-glycerate specific transporter subunit IIABC; Provisional; Region: PRK09765
591365003797	PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211
591365003798	active site
591365003799	phosphorylation site [posttranslational modification]
591365003800	PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569
591365003801	active site
591365003802	P-loop; other site
591365003803	phosphorylation site [posttranslational modification]
591365003804	Phosphotransferase system, fructose-specific IIC component [Carbohydrate transport and metabolism]; Region: FruA; COG1299
591365003805	Fructose-1-phosphate kinase and related fructose-6-phosphate kinase (PfkB) [Carbohydrate transport and metabolism]; Region: FruK; COG1105
591365003806	1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164
591365003807	putative substrate binding site [chemical binding]; other site
591365003808	putative ATP binding site [chemical binding]; other site
591365003809	Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349
591365003810	DeoR-like helix-turn-helix domain; Region: HTH_DeoR; cl17531
591365003811	DeoR C terminal sensor domain; Region: DeoRC; pfam00455
591365003812	Aminopeptidase N [Amino acid transport and metabolism]; Region: PepN; COG0308
591365003813	Peptidase M1 Aminopeptidase N family incudes tricorn interacting factor F3, Endoplasmic reticulum aminopeptidase 1 (ERAP1), Aminopeptidase Q (APQ); Region: M1_APN_2; cd09601
591365003814	Zn binding site [ion binding]; other site
591365003815	Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492
591365003816	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
591365003817	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
591365003818	phosphoglucomutase-2-like protein; Provisional; Region: PTZ00150
591365003819	This CD includes PGM2 (phosphoglucomutase 2) and PGM2L1 (phosphoglucomutase 2-like 1). The mammalian PGM2 is thought to be a phosphopentomutase that catalyzes the conversion of the nucleoside breakdown products, ribose-1-phosphate and...; Region: PGM2; cd05799
591365003820	active site
591365003821	substrate binding site [chemical binding]; other site
591365003822	metal binding site [ion binding]; metal-binding site
591365003823	Putative primosome component and related proteins [DNA replication, recombination, and repair]; Region: DnaD; COG3935
591365003824	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cl17220
591365003825	Replication initiation and membrane attachment; Region: DnaB_2; pfam07261
591365003826	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
591365003827	active site
591365003828	LrgB-like family; Region: LrgB; pfam04172
591365003829	Putative effector of murein hydrolase LrgA [General function prediction only]; Region: COG1380
591365003830	Uncharacterized conserved protein [Function unknown]; Region: COG1434
591365003831	YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259
591365003832	putative active site [active]
591365003833	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
591365003834	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
591365003835	ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254
591365003836	Walker A/P-loop; other site
591365003837	ATP binding site [chemical binding]; other site
591365003838	Q-loop/lid; other site
591365003839	ABC transporter signature motif; other site
591365003840	Walker B; other site
591365003841	D-loop; other site
591365003842	H-loop/switch region; other site
591365003843	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
591365003844	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
591365003845	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
591365003846	Walker A/P-loop; other site
591365003847	ATP binding site [chemical binding]; other site
591365003848	Q-loop/lid; other site
591365003849	ABC transporter signature motif; other site
591365003850	Walker B; other site
591365003851	D-loop; other site
591365003852	H-loop/switch region; other site
591365003853	DNA/RNA non-specific endonuclease; Region: Endonuclease_NS; smart00892
591365003854	DNA/RNA non-specific endonuclease; Region: Endonuclease_NS; pfam01223
591365003855	UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072
591365003856	UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555
591365003857	hinge; other site
591365003858	active site
591365003859	Sortase C (SrtC) or subfamily-3 sortases are membrane cysteine transpeptidases found in Gram-positive bacteria that anchor surface proteins to peptidoglycans of the bacterial cell wall envelope. This involves a transpeptidation reaction in which the...; Region: Sortase_C_3; cd05827
591365003860	active site
591365003861	catalytic site [active]
591365003862	fimbrial isopeptide formation D2 domain; Region: RrgB_K2N_iso_D2; TIGR04226
591365003863	Cna protein B-type domain; Region: Cna_B; pfam05738
591365003864	Gram positive anchor; Region: Gram_pos_anchor; pfam00746
591365003865	Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198
591365003866	metal ion-dependent adhesion site (MIDAS); other site
591365003867	Cna protein B-type domain; Region: Cna_B; pfam05738
591365003868	F0F1 ATP synthase subunit epsilon; Validated; Region: atpC; PRK00571
591365003869	mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152
591365003870	gamma subunit interface [polypeptide binding]; other site
591365003871	epsilon subunit interface [polypeptide binding]; other site
591365003872	LBP interface [polypeptide binding]; other site
591365003873	F0F1 ATP synthase subunit beta; Validated; Region: PRK09280
591365003874	ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874
591365003875	F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133
591365003876	alpha subunit interaction interface [polypeptide binding]; other site
591365003877	Walker A motif; other site
591365003878	ATP binding site [chemical binding]; other site
591365003879	Walker B motif; other site
591365003880	inhibitor binding site; inhibition site
591365003881	ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306
591365003882	mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151
591365003883	core domain interface [polypeptide binding]; other site
591365003884	delta subunit interface [polypeptide binding]; other site
591365003885	epsilon subunit interface [polypeptide binding]; other site
591365003886	F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281
591365003887	ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874
591365003888	F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132
591365003889	beta subunit interaction interface [polypeptide binding]; other site
591365003890	Walker A motif; other site
591365003891	ATP binding site [chemical binding]; other site
591365003892	Walker B motif; other site
591365003893	ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306
591365003894	F0F1 ATP synthase subunit delta; Validated; Region: PRK05758
591365003895	ATP synthase delta (OSCP) subunit; Region: OSCP; pfam00213
591365003896	F0F1-type ATP synthase, subunit b [Energy production and conversion]; Region: AtpF; COG0711
591365003897	F0F1 ATP synthase subunit B; Validated; Region: PRK05759
591365003898	F0F1-type ATP synthase, subunit a [Energy production and conversion]; Region: AtpB; COG0356
591365003899	F0F1 ATP synthase subunit A; Validated; Region: PRK05815
591365003900	This is a family of oligosaccharide phosphorylases. It includes yeast and mammalian glycogen phosphorylases, plant starch/glucan phosphorylase, as well as the maltodextrin phosphorylases of bacteria. The members of this family catalyze the breakdown of...; Region: GT1_Glycogen_Phosphorylase; cd04300
591365003901	homodimer interface [polypeptide binding]; other site
591365003902	glycogen/starch/alpha-glucan phosphorylases; Region: P_ylase; TIGR02093
591365003903	active site pocket [active]
591365003904	glycogen synthase; Provisional; Region: glgA; PRK00654
591365003905	This family is most closely related to the GT1 family of glycosyltransferases. Glycogen synthase catalyzes the formation and elongation of the alpha-1,4-glucose backbone using ADP-glucose, the second and key step of glycogen biosynthesis. This family...; Region: GT1_Glycogen_synthase_DULL1_like; cd03791
591365003906	ADP-binding pocket [chemical binding]; other site
591365003907	homodimer interface [polypeptide binding]; other site
591365003908	glucose-1-phosphate adenylyltransferase, GlgD subunit; Region: glgD; TIGR02092
591365003909	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
591365003910	active site
591365003911	Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651
591365003912	dimer interface [polypeptide binding]; other site
591365003913	N-terminal domain interface [polypeptide binding]; other site
591365003914	sulfate 1 binding site; other site
591365003915	glucose-1-phosphate adenylyltransferase; Provisional; Region: glgC; PRK05293
591365003916	ADP-glucose pyrophosphorylase is involved in the biosynthesis of glycogen or starch; Region: ADP_Glucose_PP; cd02508
591365003917	ligand binding site; other site
591365003918	oligomer interface; other site
591365003919	Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651
591365003920	dimer interface [polypeptide binding]; other site
591365003921	N-terminal domain interface [polypeptide binding]; other site
591365003922	sulfate 1 binding site; other site
591365003923	glycogen branching enzyme; Provisional; Region: PRK12313
591365003924	N-terminal Early set domain associated with the catalytic domain of prokaryotic glycogen branching enzyme; Region: E_set_GBE_prok_N; cd02855
591365003925	Alpha amylase catalytic domain found in the Glycogen branching enzyme (also called 1,4-alpha-glucan branching enzyme); Region: AmyAc_Glg_BE; cd11322
591365003926	active site
591365003927	catalytic site [active]
591365003928	Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; pfam02806
591365003929	helicase-exonuclease AddAB, AddA subunit, Firmicutes type; Region: addA_Gpos; TIGR02785
591365003930	Family description; Region: UvrD_C_2; pfam13538
591365003931	Family description; Region: UvrD_C_2; pfam13538
591365003932	PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705
591365003933	ATP-dependent nuclease subunit B; Region: rexB_recomb; TIGR02774
591365003934	PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705
591365003935	ABC-type Na+ efflux pump, permease component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatB; COG1668
591365003936	ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: COG4152
591365003937	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
591365003938	Walker A/P-loop; other site
591365003939	ATP binding site [chemical binding]; other site
591365003940	Q-loop/lid; other site
591365003941	ABC transporter signature motif; other site
591365003942	Walker B; other site
591365003943	D-loop; other site
591365003944	H-loop/switch region; other site
591365003945	Domain of unknown function (DUF4162); Region: DUF4162; pfam13732
591365003946	ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: PhnK; COG1101
591365003947	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
591365003948	Walker A/P-loop; other site
591365003949	ATP binding site [chemical binding]; other site
591365003950	Q-loop/lid; other site
591365003951	ABC transporter signature motif; other site
591365003952	Walker B; other site
591365003953	D-loop; other site
591365003954	H-loop/switch region; other site
591365003955	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
591365003956	Transmembrane subunit (TM) of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which are involved in the uptake of branched-chain amino acids (AAs), as well as TMs of transporters involved in the uptake of...; Region: TM_PBP1_branched-chain-AA_like; cd06574
591365003957	TM-ABC transporter signature motif; other site
591365003958	Type I periplasmic ligand-binding domain of uncharacterized ABC-type transport systems that are predicted to be involved in the uptake of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_uncharacterized_transporter; cd06325
591365003959	zinc binding site [ion binding]; other site
591365003960	putative ligand binding site [chemical binding]; other site
591365003961	Fibronectin-binding protein A N-terminus (FbpA); Region: FbpA; pfam05833
591365003962	Domain of unknown function (DUF814); Region: DUF814; pfam05670
591365003963	Alpha-acetolactate decarboxylase; Region: AAL_decarboxy; pfam03306
591365003964	acetolactate synthase; Reviewed; Region: PRK08617
591365003965	Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035
591365003966	PYR/PP interface [polypeptide binding]; other site
591365003967	dimer interface [polypeptide binding]; other site
591365003968	TPP binding site [chemical binding]; other site
591365003969	Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205
591365003970	Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629
591365003971	TPP-binding site [chemical binding]; other site
591365003972	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
591365003973	binding surface
591365003974	TPR motif; other site
591365003975	Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628
591365003976	Domain of unknown function DUF20; Region: UPF0118; pfam01594
591365003977	cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814; cl03223
591365003978	FeS assembly protein SufB; Region: sufB; TIGR01980
591365003979	flavodoxin; Validated; Region: PRK07308
591365003980	Exopolyphosphatase-related proteins [General function prediction only]; Region: COG0618
591365003981	DHH family; Region: DHH; pfam01368
591365003982	50S ribosomal protein L31 type B; Reviewed; Region: rpmE2; PRK01678
591365003983	Predicted O-methyltransferase [General function prediction only]; Region: COG4123
591365003984	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
591365003985	S-adenosylmethionine binding site [chemical binding]; other site
591365003986	The GIY-YIG domain of uncharacterized protein family UPF0213 related to structure-specific endonuclease SLX1; Region: GIY-YIG_UPF0213; cd10456
591365003987	GIY-YIG motif/motif A; other site
591365003988	putative active site [active]
591365003989	putative metal binding site [ion binding]; other site
591365003990	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1755
591365003991	6-phospho-beta-galactosidase; Provisional; Region: PRK13511
591365003992	beta-galactosidase; Region: BGL; TIGR03356
591365003993	Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; cl17295
591365003994	Phosphotransferase system, EIIC; Region: PTS_EIIC; pfam02378
591365003995	PTS_IIB_lactose: subunit IIB of enzyme II (EII) of the lactose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS) found in Firmicutes as well as Actinobacteria. In this system, EII is a lactose-specific permease with two...; Region: PTS_IIB_lactose; cd05565
591365003996	active site
591365003997	P-loop; other site
591365003998	phosphorylation site [posttranslational modification]
591365003999	PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_lac; cd00215
591365004000	methionine cluster; other site
591365004001	active site
591365004002	phosphorylation site [posttranslational modification]
591365004003	metal binding site [ion binding]; metal-binding site
591365004004	CAT RNA binding domain; Region: CAT_RBD; smart01061
591365004005	transcriptional antiterminator BglG; Provisional; Region: PRK09772
591365004006	PRD domain; Region: PRD; pfam00874
591365004007	PRD domain; Region: PRD; pfam00874
591365004008	Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837
591365004009	Beta-galactosidase/beta-glucuronidase [Carbohydrate transport and metabolism]; Region: LacZ; COG3250
591365004010	Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703
591365004011	Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836
591365004012	Bacterial Ig-like domain (group 4); Region: Big_4; pfam07532
591365004013	F5/8 type C domain; Region: F5_F8_type_C; pfam00754
591365004014	sugar binding site [chemical binding]; other site
591365004015	Glycosyl hydrolase family 20 (GH20) catalytic domain of dispersin B (DspB), lacto-N-biosidase (LnbB) and related proteins. Dispersin B is a soluble beta-N-acetylglucosamidase found in bacteria that hydrolyzes the beta-1,6-linkages of PGA (poly-beta-(1,6)...; Region: GH20_DspB_LnbB-like; cd06564
591365004016	Glycosyl hydrolase family 20, catalytic domain; Region: Glyco_hydro_20; pfam00728
591365004017	active site
591365004018	Fructose-1-phosphate kinase and related fructose-6-phosphate kinase (PfkB) [Carbohydrate transport and metabolism]; Region: FruK; COG1105
591365004019	ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase; Region: ribokinase_pfkB_like; cl00192
591365004020	substrate binding site [chemical binding]; other site
591365004021	ATP binding site [chemical binding]; other site
591365004022	Phosphotransferase system, galactitol-specific IIC component [Carbohydrate transport and metabolism]; Region: GatC; COG3775
591365004023	PTS system sugar-specific permease component; Region: EIIC-GAT; pfam03611
591365004024	PTS_IIB_galactitol: subunit IIB of enzyme II (EII) of the galactitol-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS).  In this system, EII is a galactitol-specific permease with two cytoplasmic domains (IIA and IIB) and a...; Region: PTS_IIB_galactitol; cd05566
591365004025	active site
591365004026	P-loop; other site
591365004027	phosphorylation site [posttranslational modification]
591365004028	PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211
591365004029	active site
591365004030	phosphorylation site [posttranslational modification]
591365004031	Ribose/Galactose Isomerase; Region: LacAB_rpiB; cl00485
591365004032	galactose-6-phosphate isomerase subunit LacB; Reviewed; Region: PRK08622
591365004033	Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349
591365004034	helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420
591365004035	DeoR C terminal sensor domain; Region: DeoRC; pfam00455
591365004036	Class I aldolases; Region: Aldolase_Class_I; cl17187
591365004037	ATP-dependent RNA helicase SrmB; Provisional; Region: PRK11192
591365004038	DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker  B motif; Region: DEADc; cd00268
591365004039	ATP binding site [chemical binding]; other site
591365004040	Mg++ binding site [ion binding]; other site
591365004041	motif III; other site
591365004042	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
591365004043	nucleotide binding region [chemical binding]; other site
591365004044	ATP-binding site [chemical binding]; other site
591365004045	CorA-like Mg2+ transporter protein; Region: CorA; pfam01544
591365004046	uncharacterized bacterial subfamily of the Escherichia coli CorA-Salmonella typhimurium ZntB family; Region: EcCorA_ZntB-like_u2; cd12827
591365004047	Cl binding site [ion binding]; other site
591365004048	oligomer interface [polypeptide binding]; other site
591365004049	peptide chain release factor 3; Provisional; Region: prfC; PRK00741
591365004050	Release Factor 3 (RF3) protein involved in the terminal step of translocation in bacteria; Region: RF3; cd04169
591365004051	G1 box; other site
591365004052	putative GEF interaction site [polypeptide binding]; other site
591365004053	GTP/Mg2+ binding site [chemical binding]; other site
591365004054	Switch I region; other site
591365004055	G2 box; other site
591365004056	G3 box; other site
591365004057	Switch II region; other site
591365004058	G4 box; other site
591365004059	G5 box; other site
591365004060	RF3_II: this subfamily represents the domain II of bacterial Release Factor 3 (RF3). Termination of protein synthesis by the ribosome requires two release factor (RF) classes. The class II RF3 is a GTPase that removes class I RFs (RF1 or RF2) from the...; Region: RF3_II; cd03689
591365004061	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
591365004062	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
591365004063	non-specific DNA binding site [nucleotide binding]; other site
591365004064	salt bridge; other site
591365004065	sequence-specific DNA binding site [nucleotide binding]; other site
591365004066	Integral membrane protein (intg_mem_TP0381); Region: Intg_mem_TP0381; pfam09529
591365004067	Integral membrane protein (intg_mem_TP0381); Region: Intg_mem_TP0381; pfam09529
591365004068	Protein of unknown function (DUF1697); Region: DUF1697; pfam08002
591365004069	UDP-N-acetylmuramyl pentapeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurF; COG0770
591365004070	Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225
591365004071	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
591365004072	D-alanyl-alanine synthetase A; Reviewed; Region: ddl; PRK01966
591365004073	D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820
591365004074	D-ala D-ala ligase C-terminus; Region: Dala_Dala_lig_C; pfam07478
591365004075	recombination protein RecR; Reviewed; Region: recR; PRK00076
591365004076	RecR protein; Region: RecR; pfam02132
591365004077	TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR.  RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025
591365004078	putative active site [active]
591365004079	putative metal-binding site [ion binding]; other site
591365004080	tetramer interface [polypeptide binding]; other site
591365004081	Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768
591365004082	Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717
591365004083	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905
591365004084	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
591365004085	catalytic core [active]
591365004086	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
591365004087	Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153
591365004088	metal binding site 2 [ion binding]; metal-binding site
591365004089	putative DNA binding helix; other site
591365004090	metal binding site 1 [ion binding]; metal-binding site
591365004091	dimer interface [polypeptide binding]; other site
591365004092	structural Zn2+ binding site [ion binding]; other site
591365004093	EDD domain protein, DegV family; Region: DegV; TIGR00762
591365004094	Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645
591365004095	iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577
591365004096	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
591365004097	ABC-ATPase subunit  interface; other site
591365004098	dimer interface [polypeptide binding]; other site
591365004099	putative PBP binding regions; other site
591365004100	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
591365004101	ABC-ATPase subunit  interface; other site
591365004102	dimer interface [polypeptide binding]; other site
591365004103	putative PBP binding regions; other site
591365004104	ABC-type enterochelin transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CeuD; COG4604
591365004105	ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214
591365004106	Walker A/P-loop; other site
591365004107	ATP binding site [chemical binding]; other site
591365004108	Q-loop/lid; other site
591365004109	ABC transporter signature motif; other site
591365004110	Walker B; other site
591365004111	D-loop; other site
591365004112	H-loop/switch region; other site
591365004113	ABC-type enterochelin transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: CeuA; COG4607
591365004114	Siderophore binding protein FatB.  These proteins have been shown to function as ABC-type initial receptors in the siderophore-mediated iron uptake in some eubacterial species.  They belong to the TroA superfamily of periplasmic metal binding proteins...; Region: FatB; cd01140
591365004115	putative ligand binding residues [chemical binding]; other site
591365004116	phosphoprotein phosphatases of the metallophosphatase superfamily, metallophosphatase domain; Region: MPP_PPP_family; cd00144
591365004117	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
591365004118	active site
591365004119	metal binding site [ion binding]; metal-binding site
591365004120	ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: RecN; COG0497
591365004121	ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241
591365004122	Walker A/P-loop; other site
591365004123	ATP binding site [chemical binding]; other site
591365004124	Q-loop/lid; other site
591365004125	ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241
591365004126	ABC transporter signature motif; other site
591365004127	Walker B; other site
591365004128	D-loop; other site
591365004129	H-loop/switch region; other site
591365004130	Arginine repressor [Transcription]; Region: ArgR; COG1438
591365004131	Arginine repressor, DNA binding domain; Region: Arg_repressor; pfam01316
591365004132	Arginine repressor, C-terminal domain; Region: Arg_repressor_C; pfam02863
591365004133	Predicted rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: COG1189
591365004134	S4 RNA-binding domain; Region: S4; smart00363
591365004135	RNA binding surface [nucleotide binding]; other site
591365004136	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
591365004137	S-adenosylmethionine binding site [chemical binding]; other site
591365004138	Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142
591365004139	Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685
591365004140	substrate binding pocket [chemical binding]; other site
591365004141	chain length determination region; other site
591365004142	substrate-Mg2+ binding site; other site
591365004143	catalytic residues [active]
591365004144	aspartate-rich region 1; other site
591365004145	active site lid residues [active]
591365004146	aspartate-rich region 2; other site
591365004147	exodeoxyribonuclease VII large subunit; Reviewed; Region: xseA; PRK00286
591365004148	ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489
591365004149	generic binding surface II; other site
591365004150	generic binding surface I; other site
591365004151	MarR family; Region: MarR_2; pfam12802
591365004152	Acyl-CoA thioester hydrolase/BAAT N-terminal region; Region: Bile_Hydr_Trans; pfam04775
591365004153	BAAT / Acyl-CoA thioester hydrolase C terminal; Region: BAAT_C; pfam08840
591365004154	Beta-fructosidases (levanase/invertase) [Carbohydrate transport and metabolism]; Region: SacC; COG1621
591365004155	Glycosyl hydrolase family 32, beta-fructosidases; Region: GH32_B_Fructosidase; cd08996
591365004156	substrate binding [chemical binding]; other site
591365004157	active site
591365004158	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
591365004159	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
591365004160	dimer interface [polypeptide binding]; other site
591365004161	conserved gate region; other site
591365004162	putative PBP binding loops; other site
591365004163	ABC-ATPase subunit interface; other site
591365004164	ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209
591365004165	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
591365004166	putative PBP binding loops; other site
591365004167	dimer interface [polypeptide binding]; other site
591365004168	ABC-ATPase subunit interface; other site
591365004169	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
591365004170	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
591365004171	Transcriptional regulators [Transcription]; Region: PurR; COG1609
591365004172	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
591365004173	DNA binding site [nucleotide binding]
591365004174	domain linker motif; other site
591365004175	Ligand binding domain of the lacI-like transcription regulator from a novel metal-reducing bacterium Alkaliphilus Metalliredigens (strain Qymf) and its close homologs; Region: PBP1_Qymf_like; cd06291
591365004176	dimerization interface [polypeptide binding]; other site
591365004177	ligand binding site [chemical binding]; other site
591365004178	sodium binding site [ion binding]; other site
591365004179	B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171
591365004180	putative substrate binding site [chemical binding]; other site
591365004181	putative ATP binding site [chemical binding]; other site
591365004182	bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK14179
591365004183	Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763
591365004184	NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080
591365004185	homodimer interface [polypeptide binding]; other site
591365004186	NADP binding site [chemical binding]; other site
591365004187	substrate binding site [chemical binding]; other site
591365004188	ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577
591365004189	FtsX-like permease family; Region: FtsX; pfam02687
591365004190	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
591365004191	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
591365004192	Walker A/P-loop; other site
591365004193	ATP binding site [chemical binding]; other site
591365004194	Q-loop/lid; other site
591365004195	ABC transporter signature motif; other site
591365004196	Walker B; other site
591365004197	D-loop; other site
591365004198	H-loop/switch region; other site
591365004199	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
591365004200	ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577
591365004201	FtsX-like permease family; Region: FtsX; pfam02687
591365004202	Protein of unknown function (DUF1706); Region: DUF1706; pfam08020
591365004203	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
591365004204	ATPases associated with a variety of cellular activities; Region: AAA; smart00382
591365004205	Walker A motif; other site
591365004206	ATP binding site [chemical binding]; other site
591365004207	Walker B motif; other site
591365004208	arginine finger; other site
591365004209	UvrB/uvrC motif; Region: UVR; pfam02151
591365004210	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
591365004211	ATPases associated with a variety of cellular activities; Region: AAA; smart00382
591365004212	Walker A motif; other site
591365004213	ATP binding site [chemical binding]; other site
591365004214	Walker B motif; other site
591365004215	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431
591365004216	GyrI-like small molecule binding domain; Region: GyrI-like; cl01368
591365004217	HTH domain; Region: HTH_11; pfam08279
591365004218	Predicted transcriptional regulator [Transcription]; Region: COG2378
591365004219	WYL domain; Region: WYL; pfam13280
591365004220	Contains a crystal structure of the Nudix hydrolase from Enterococcus faecalis, which has an unknown function. In general, members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes...; Region: Nudix_Hydrolase_25; cd04684
591365004221	nudix motif; other site
591365004222	Domain of unknown function (DUF1827); Region: DUF1827; pfam08860
591365004223	NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025
591365004224	Putative rRNA methylase; Region: rRNA_methylase; pfam06962
591365004225	Predicted Fe-S oxidoreductase [General function prediction only]; Region: COG1242
591365004226	The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445
591365004227	active site
591365004228	DNA binding site [nucleotide binding]
591365004229	Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671
591365004230	PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392
591365004231	active site
591365004232	Predicted membrane protein [Function unknown]; Region: COG3601
591365004233	Protein of unknown function (DUF3816); Region: DUF3816; pfam12822
591365004234	Predicted rRNA methylase (SpoU class) [Translation, ribosomal structure and biogenesis]; Region: CspR; COG0219
591365004235	TrkA-N domain; Region: TrkA_N; pfam02254
591365004236	potassium transporter peripheral membrane component; Reviewed; Region: trkA; PRK09496
591365004237	TrkA-C domain; Region: TrkA_C; pfam02080
591365004238	TrkA-N domain; Region: TrkA_N; pfam02254
591365004239	TrkA-C domain; Region: TrkA_C; pfam02080
591365004240	Trk-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: TrkG; COG0168
591365004241	potassium uptake protein, TrkH family; Region: 2a38; TIGR00933
591365004242	16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187
591365004243	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
591365004244	RNA binding surface [nucleotide binding]; other site
591365004245	Pseudouridine synthases, RsuA subfamily; Region: PseudoU_synth_RsuA_like; cd02870
591365004246	active site
591365004247	segregation and condensation protein B; Reviewed; Region: scpB; PRK00135
591365004248	segregation and condensation protein A; Reviewed; Region: scpA; PRK00104
591365004249	site-specific tyrosine recombinase XerD-like protein; Reviewed; Region: xerD; PRK02436
591365004250	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
591365004251	DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182
591365004252	DNA binding site [nucleotide binding]
591365004253	Int/Topo IB signature motif; other site
591365004254	active site
591365004255	catalytic residues [active]
591365004256	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_30; cd04643
591365004257	FOG: CBS domain [General function prediction only]; Region: COG0517
591365004258	Escherichia coli YfcE and related proteins, metallophosphatase domain; Region: MPP_YfcE; cd00841
591365004259	active site
591365004260	metal binding site [ion binding]; metal-binding site
591365004261	homotetramer interface [polypeptide binding]; other site
591365004262	putative deoxyribonucleotide triphosphate pyrophosphatase/unknown domain fusion protein; Reviewed; Region: PRK02491
591365004263	NTPase/HAM1.  This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515
591365004264	active site
591365004265	dimerization interface [polypeptide binding]; other site
591365004266	glutamate racemase; Provisional; Region: PRK00865
591365004267	Diaminopimelate decarboxylase [Amino acid transport and metabolism]; Region: LysA; COG0019
591365004268	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828
591365004269	active site
591365004270	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
591365004271	substrate binding site [chemical binding]; other site
591365004272	catalytic residues [active]
591365004273	dimer interface [polypeptide binding]; other site
591365004274	Integral membrane protein, interacts with FtsH [General function prediction only]; Region: COG0670
591365004275	Bacterial BAX inhibitor (BI)-1/YccA-like proteins; Region: BI-1-like_bacterial; cd10432
591365004276	Predicted HD superfamily hydrolase [General function prediction only]; Region: COG1418
591365004277	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
591365004278	Zn2+ binding site [ion binding]; other site
591365004279	Mg2+ binding site [ion binding]; other site
591365004280	rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566
591365004281	RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; smart00967
591365004282	SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588
591365004283	OxaA-like protein precursor; Provisional; Region: PRK02463
591365004284	membrane protein insertase, YidC/Oxa1 family, C-terminal domain; Region: yidC_oxa1_cterm; TIGR03592
591365004285	MutT homolog-1 (MTH1) is a member of the Nudix hydrolase superfamily. MTH1, the mammalian counterpart of MutT, hydrolyzes oxidized purine nucleoside triphosphates, such as 8-oxo-dGTP and 2-hydroxy-ATP, to monophosphates, thereby preventing the...; Region: MTH1; cd03427
591365004286	putative active site [active]
591365004287	nucleotide binding site [chemical binding]; other site
591365004288	nudix motif; other site
591365004289	putative metal binding site [ion binding]; other site
591365004290	transcription elongation factor GreA; Reviewed; Region: greA; PRK00226
591365004291	Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449
591365004292	Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272
591365004293	Aminodeoxychorismate lyase [Coenzyme transport and metabolism]; Region: COG1559
591365004294	proteins similar to Escherichia coli yceG; Region: yceG_like; cd08010
591365004295	dimerization interface [polypeptide binding]; other site
591365004296	Acetyltransferase (GNAT) domain; Region: Acetyltransf_4; pfam13420
591365004297	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
591365004298	Coenzyme A binding pocket [chemical binding]; other site
591365004299	ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575
591365004300	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
591365004301	Coenzyme A binding pocket [chemical binding]; other site
591365004302	UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421
591365004303	Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225
591365004304	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
591365004305	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
591365004306	Bacterial SNF2 helicase associated; Region: SNF2_assoc; pfam08455
591365004307	SNF2 family N-terminal domain; Region: SNF2_N; pfam00176
591365004308	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
591365004309	ATP binding site [chemical binding]; other site
591365004310	putative Mg++ binding site [ion binding]; other site
591365004311	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
591365004312	nucleotide binding region [chemical binding]; other site
591365004313	ATP-binding site [chemical binding]; other site
591365004314	GTP-binding protein Der; Reviewed; Region: PRK00093
591365004315	EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894
591365004316	G1 box; other site
591365004317	GTP/Mg2+ binding site [chemical binding]; other site
591365004318	Switch I region; other site
591365004319	G2 box; other site
591365004320	Switch II region; other site
591365004321	G3 box; other site
591365004322	G4 box; other site
591365004323	G5 box; other site
591365004324	EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895
591365004325	G1 box; other site
591365004326	GTP/Mg2+ binding site [chemical binding]; other site
591365004327	Switch I region; other site
591365004328	G2 box; other site
591365004329	G3 box; other site
591365004330	Switch II region; other site
591365004331	G4 box; other site
591365004332	G5 box; other site
591365004333	This family contains NADPH-dependent flavin reductase and oxygen-insensitive nitroreductase. These enzymes are homodimeric flavoproteins that contain one FMN per monomer as a cofactor. Flavin reductase catalyzes the reduction of flavin by using NADPH as...; Region: NfsA_FRP; cd02146
591365004334	dimer interface [polypeptide binding]; other site
591365004335	FMN binding site [chemical binding]; other site
591365004336	NADPH bind site [chemical binding]; other site
591365004337	primosomal protein DnaI; Reviewed; Region: PRK08939
591365004338	Primosomal protein DnaI N-terminus; Region: DnaI_N; pfam07319
591365004339	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
591365004340	Walker A motif; other site
591365004341	ATP binding site [chemical binding]; other site
591365004342	Walker B motif; other site
591365004343	Replication initiation/membrane attachment protein [DNA replication, recombination, and repair]; Region: DnaB; COG3611
591365004344	transcriptional regulator NrdR; Validated; Region: nrdR; PRK00464
591365004345	ATP cone domain; Region: ATP-cone; pfam03477
591365004346	Streptococcus agalactiae RgfB, part of a putative two component signal transduction system, and related proteins; Region: RgfB-like; cd09079
591365004347	putative catalytic site [active]
591365004348	putative metal binding site [ion binding]; other site
591365004349	putative phosphate binding site [ion binding]; other site
591365004350	Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263
591365004351	PTS system, IIBC component; Region: PTS-II-BC-unk1; TIGR02003
591365004352	PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212
591365004353	active site turn [active]
591365004354	phosphorylation site [posttranslational modification]
591365004355	Phosphotransferase system IIA components [Carbohydrate transport and metabolism]; Region: NagE; COG2190
591365004356	HPr interaction site; other site
591365004357	glycerol kinase (GK) interaction site [polypeptide binding]; other site
591365004358	active site
591365004359	phosphorylation site [posttranslational modification]
591365004360	Phosphotransferase system IIA components [Carbohydrate transport and metabolism]; Region: NagE; COG2190
591365004361	HPr interaction site; other site
591365004362	glycerol kinase (GK) interaction site [polypeptide binding]; other site
591365004363	active site
591365004364	phosphorylation site [posttranslational modification]
591365004365	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
591365004366	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
591365004367	active site
591365004368	phosphorylation site [posttranslational modification]
591365004369	intermolecular recognition site; other site
591365004370	dimerization interface [polypeptide binding]; other site
591365004371	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
591365004372	DNA binding site [nucleotide binding]
591365004373	6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599
591365004374	6-phosphogluconate dehydrogenase; Validated; Region: PRK09287
591365004375	6-phosphogluconate dehydrogenase, C-terminal domain; Region: 6PGD; pfam00393
591365004376	Predicted metal-binding, possibly nucleic acid-binding protein [General function prediction only]; Region: COG1399
591365004377	heat shock protein HtpX; Provisional; Region: PRK04897
591365004378	Uncharacterized conserved protein [Function unknown]; Region: LemA; COG1704
591365004379	Predicted S-adenosylmethionine-dependent methyltransferase involved in bacterial cell division [Cell envelope biogenesis, outer membrane]; Region: GidB; COG0357
591365004380	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
591365004381	S-adenosylmethionine binding site [chemical binding]; other site
591365004382	potential frameshift: common BLAST hit: gi|336064174|ref|YP_004559033.1| glycosyl transferase family protein
591365004383	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
591365004384	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
591365004385	active site
591365004386	malonic semialdehyde reductase; Provisional; Region: PRK10538
591365004387	classical (c) SDR, subgroup 5; Region: SDR_c5; cd05346
591365004388	putative NAD(P) binding site [chemical binding]; other site
591365004389	homotetramer interface [polypeptide binding]; other site
591365004390	homodimer interface [polypeptide binding]; other site
591365004391	active site
591365004392	ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619
591365004393	ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122
591365004394	First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225
591365004395	Walker A/P-loop; other site
591365004396	ATP binding site [chemical binding]; other site
591365004397	Q-loop/lid; other site
591365004398	ABC transporter signature motif; other site
591365004399	Walker B; other site
591365004400	D-loop; other site
591365004401	H-loop/switch region; other site
591365004402	ATP-binding cassette cobalt transporter; Region: DUF3744; pfam12558
591365004403	ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122
591365004404	First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225
591365004405	Walker A/P-loop; other site
591365004406	ATP binding site [chemical binding]; other site
591365004407	Q-loop/lid; other site
591365004408	ABC transporter signature motif; other site
591365004409	Walker B; other site
591365004410	D-loop; other site
591365004411	H-loop/switch region; other site
591365004412	Phosphorylase superfamily; Region: PNP_UDP_1; pfam01048
591365004413	hypothetical protein; Provisional; Region: PRK13661
591365004414	Uncharacterized conserved protein [Function unknown]; Region: COG1912
591365004415	ABC-type metal ion transport system, permease component [Inorganic ion transport and metabolism]; Region: AbcD; COG2011
591365004416	ABC-type metal ion transport system, ATPase component [Inorganic ion transport and metabolism]; Region: AbcC; COG1135
591365004417	ATP-binding cassette domain of methionine transporter; Region: ABC_MetN_methionine_transporter; cd03258
591365004418	Walker A/P-loop; other site
591365004419	ATP binding site [chemical binding]; other site
591365004420	Q-loop/lid; other site
591365004421	ABC transporter signature motif; other site
591365004422	Walker B; other site
591365004423	D-loop; other site
591365004424	H-loop/switch region; other site
591365004425	NIL domain; Region: NIL; pfam09383
591365004426	hypothetical protein; Provisional; Region: PRK06446
591365004427	Uncharacterized M20 Dipeptidases; Region: M20_dipept_like_4; cd05681
591365004428	metal binding site [ion binding]; metal-binding site
591365004429	dimer interface [polypeptide binding]; other site
591365004430	ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464
591365004431	NLPA lipoprotein; Region: Lipoprotein_9; pfam03180
591365004432	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
591365004433	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
591365004434	substrate binding pocket [chemical binding]; other site
591365004435	membrane-bound complex binding site; other site
591365004436	hinge residues; other site
591365004437	Domain of unknown function (DUF4352); Region: DUF4352; pfam11611
591365004438	hypothetical protein; Provisional; Region: PRK12378
591365004439	hypothetical protein; Provisional; Region: PRK13670
591365004440	HIGH Nucleotidyl Transferase; Region: HIGH_NTase1; cl17673
591365004441	Type I site-specific restriction-modification system, R (restriction) subunit and related helicases [Defense mechanisms]; Region: COG0610
591365004442	Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; pfam04313
591365004443	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251
591365004444	Helix-turn-helix domain; Region: HTH_17; pfam12728
591365004445	Fic family protein [Function unknown]; Region: COG3177
591365004446	Fic/DOC family; Region: Fic; pfam02661
591365004447	Fic/DOC family; Region: Fic; cl00960
591365004448	Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420
591365004449	Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732
591365004450	Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420
591365004451	HsdM N-terminal domain; Region: HsdM_N; pfam12161
591365004452	Type I restriction-modification system methyltransferase subunit [Defense mechanisms]; Region: HsdM; COG0286
591365004453	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173
591365004454	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
591365004455	S-adenosylmethionine binding site [chemical binding]; other site
591365004456	Uncharacterized homolog of plant Iojap protein [Function unknown]; Region: COG0799
591365004457	Isochorismatase family; Region: Isochorismatase; pfam00857
591365004458	Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cl00220
591365004459	catalytic triad [active]
591365004460	conserved cis-peptide bond; other site
591365004461	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
591365004462	Zn2+ binding site [ion binding]; other site
591365004463	Mg2+ binding site [ion binding]; other site
591365004464	nicotinic acid mononucleotide adenylyltransferase; Provisional; Region: nadD; PRK00071
591365004465	Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165
591365004466	active site
591365004467	(T/H)XGH motif; other site
591365004468	Predicted RNA-binding protein containing KH domain, possibly ribosomal protein [Translation, ribosomal structure and biogenesis]; Region: COG1534
591365004469	GTPase YqeH; Provisional; Region: PRK13796
591365004470	Circularly permuted YqeH GTPase; Region: YqeH; cd01855
591365004471	GTP/Mg2+ binding site [chemical binding]; other site
591365004472	G4 box; other site
591365004473	G5 box; other site
591365004474	G1 box; other site
591365004475	Switch I region; other site
591365004476	G2 box; other site
591365004477	G3 box; other site
591365004478	Switch II region; other site
591365004479	Predicted hydrolase of the HAD superfamily [General function prediction only]; Region: COG2179
591365004480	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
591365004481	active site
591365004482	motif I; other site
591365004483	motif II; other site
591365004484	Uncharacterized conserved protein [Function unknown]; Region: COG0398
591365004485	SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335
591365004486	Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950
591365004487	EamA-like transporter family; Region: EamA; pfam00892
591365004488	Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063
591365004489	(2R,3R)-2,3-butanediol dehydrogenase; Region: butanediol_DH_like; cd08233
591365004490	putative NAD(P) binding site [chemical binding]; other site
591365004491	catalytic Zn binding site [ion binding]; other site
591365004492	aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477
591365004493	GatB/GatE catalytic domain; Region: GatB_N; pfam02934
591365004494	GatB domain; Region: GatB_Yqey; pfam02637
591365004495	Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154
591365004496	aspartyl/glutamyl-tRNA amidotransferase subunit A; Reviewed; Region: gatA; PRK00012
591365004497	aspartyl/glutamyl-tRNA amidotransferase subunit C; Reviewed; Region: gatC; PRK00034
591365004498	potential frameshift: common BLAST hit: gi|125717428|ref|YP_001034561.1| aspartyl-tRNA synthetase
591365004499	tRNA synthetases class II (D, K and N); Region: tRNA-synt_2; pfam00152
591365004500	Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777
591365004501	homodimer interface [polypeptide binding]; other site
591365004502	motif 1; other site
591365004503	active site
591365004504	motif 2; other site
591365004505	GAD domain; Region: GAD; pfam02938
591365004506	Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA.   PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268
591365004507	active site
591365004508	motif 3; other site
591365004509	Replication protein A, class 2b aminoacyl-tRNA synthetases, and related proteins with oligonucleotide/oligosaccharide (OB) fold; Region: RPA_2b-aaRSs_OBF_like; cl09930
591365004510	Dimer interface [polypeptide binding]; other site
591365004511	anticodon binding site; other site
591365004512	Isochorismatase family; Region: Isochorismatase; pfam00857
591365004513	Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431
591365004514	catalytic triad [active]
591365004515	conserved cis-peptide bond; other site
591365004516	Pleiotropic transcriptional repressor [Transcription]; Region: CodY; COG4465
591365004517	CodY GAF-like domain; Region: CodY; pfam06018
591365004518	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
591365004519	dimerization interface [polypeptide binding]; other site
591365004520	putative Zn2+ binding site [ion binding]; other site
591365004521	putative DNA binding site [nucleotide binding]; other site
591365004522	aminotransferase AlaT; Validated; Region: PRK09265
591365004523	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
591365004524	pyridoxal 5'-phosphate binding site [chemical binding]; other site
591365004525	homodimer interface [polypeptide binding]; other site
591365004526	catalytic residue [active]
591365004527	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
591365004528	Ligand Binding Site [chemical binding]; other site
591365004529	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
591365004530	haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282
591365004531	active site
591365004532	motif I; other site
591365004533	motif II; other site
591365004534	haloacid dehalogenase-like hydrolase; Region: HAD; cl17202
591365004535	Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in Exiguobacterium sibiricum YP_001813558.1 protein and its bacterial homologs; Region: NTP-PPase_YP_001813558; cd11545
591365004536	putative nucleotide binding site [chemical binding]; other site
591365004537	putative metal binding site [ion binding]; other site
591365004538	Type II (periplasmic) bacterial L-asparaginase; Region: L-asparaginase_II; cd08964
591365004539	active site
591365004540	homotetramer interface [polypeptide binding]; other site
591365004541	homodimer interface [polypeptide binding]; other site
591365004542	ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917
591365004543	Y-family of DNA polymerases; Region: PolY; cl12025
591365004544	RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488
591365004545	generic binding surface II; other site
591365004546	ssDNA binding site; other site
591365004547	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
591365004548	ATP binding site [chemical binding]; other site
591365004549	putative Mg++ binding site [ion binding]; other site
591365004550	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
591365004551	nucleotide binding region [chemical binding]; other site
591365004552	ATP-binding site [chemical binding]; other site
591365004553	alanine racemase; Reviewed; Region: alr; PRK00053
591365004554	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430
591365004555	active site
591365004556	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
591365004557	dimer interface [polypeptide binding]; other site
591365004558	substrate binding site [chemical binding]; other site
591365004559	catalytic residues [active]
591365004560	4'-phosphopantetheinyl transferase; Provisional; Region: acpS; PRK00070
591365004561	3-deoxy-D-arabino-heptulosonate 7-phosphate (DAHP) synthase [Amino acid transport and metabolism]; Region: AroG; cl17260
591365004562	DAHP synthetase I family; Region: DAHP_synth_1; pfam00793
591365004563	preprotein translocase subunit SecA; Reviewed; Region: PRK12904
591365004564	SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958
591365004565	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
591365004566	nucleotide binding region [chemical binding]; other site
591365004567	ATP-binding site [chemical binding]; other site
591365004568	SEC-C motif; Region: SEC-C; pfam02810
591365004569	potential frameshift: common BLAST hit: gi|157151008|ref|YP_001449672.1| transporter
591365004570	Amino acid permease; Region: AA_permease_2; pfam13520
591365004571	Uncharacterized membrane protein [Function unknown]; Region: COG3949
591365004572	LXG domain of WXG superfamily; Region: LXG; pfam04740
591365004573	Phosphomannose isomerase [Carbohydrate transport and metabolism]; Region: ManA; COG1482
591365004574	mannose-6-phosphate isomerase, class I; Region: manA; TIGR00218
591365004575	Transcriptional regulators [Transcription]; Region: PhnF; COG2188
591365004576	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
591365004577	DNA-binding site [nucleotide binding]; DNA binding site
591365004578	The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; Region: UTRA; smart00866
591365004579	Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455
591365004580	cellobiose phosphotransferase system IIC component; Reviewed; Region: celD; PRK09592
591365004581	Beta-glucosidase/6-phospho-beta-glucosidase/beta- galactosidase [Carbohydrate transport and metabolism]; Region: BglB; COG2723
591365004582	beta-galactosidase; Region: BGL; TIGR03356
591365004583	Cupin domain; Region: Cupin_2; pfam07883
591365004584	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
591365004585	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
591365004586	ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254
591365004587	Walker A/P-loop; other site
591365004588	ATP binding site [chemical binding]; other site
591365004589	Q-loop/lid; other site
591365004590	ABC transporter signature motif; other site
591365004591	Walker B; other site
591365004592	D-loop; other site
591365004593	H-loop/switch region; other site
591365004594	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
591365004595	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
591365004596	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
591365004597	Walker A/P-loop; other site
591365004598	ATP binding site [chemical binding]; other site
591365004599	Q-loop/lid; other site
591365004600	ABC transporter signature motif; other site
591365004601	Walker B; other site
591365004602	D-loop; other site
591365004603	H-loop/switch region; other site
591365004604	Transcriptional regulators [Transcription]; Region: MarR; COG1846
591365004605	MarR family; Region: MarR_2; pfam12802
591365004606	NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902
591365004607	Old yellow enzyme (OYE)-related FMN binding domain, group 4.  Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a reducing agent with oxygens, quinones, and alpha,beta-unsaturated aldehydes and ketones, and can act as...; Region: OYE_like_4_FMN; cd04735
591365004608	putative active site [active]
591365004609	putative FMN binding site [chemical binding]; other site
591365004610	putative substrate binding site [chemical binding]; other site
591365004611	putative catalytic residue [active]
591365004612	Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487
591365004613	active site
591365004614	catalytic residues [active]
591365004615	metal binding site [ion binding]; metal-binding site
591365004616	Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940
591365004617	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012
591365004618	nucleotide binding site [chemical binding]; other site
591365004619	PTS system, sucrose-specific IIBC component; Region: PTS-II-BC-sucr; TIGR01996
591365004620	PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212
591365004621	active site turn [active]
591365004622	phosphorylation site [posttranslational modification]
591365004623	Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263
591365004624	PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_glc; cd00210
591365004625	HPr interaction site; other site
591365004626	glycerol kinase (GK) interaction site [polypeptide binding]; other site
591365004627	active site
591365004628	phosphorylation site [posttranslational modification]
591365004629	sucrose-6-phosphate hydrolase; Region: scrB_fam; TIGR01322
591365004630	Glycosyl hydrolase family 32, beta-fructosidases; Region: GH32_B_Fructosidase; cd08996
591365004631	substrate binding [chemical binding]; other site
591365004632	active site
591365004633	Glycosyl hydrolases family 32 C terminal; Region: Glyco_hydro_32C; pfam08244
591365004634	Transcriptional regulators [Transcription]; Region: PurR; COG1609
591365004635	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
591365004636	DNA binding site [nucleotide binding]
591365004637	domain linker motif; other site
591365004638	Ligand binding domain of the lacI-like transcription regulator from a novel metal-reducing bacterium Alkaliphilus Metalliredigens (strain Qymf) and its close homologs; Region: PBP1_Qymf_like; cd06291
591365004639	dimerization interface [polypeptide binding]; other site
591365004640	ligand binding site [chemical binding]; other site
591365004641	sodium binding site [ion binding]; other site
591365004642	Predicted hydrolases of the HAD superfamily [General function prediction only]; Region: Cof; COG0561
591365004643	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
591365004644	active site
591365004645	motif I; other site
591365004646	motif II; other site
591365004647	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cl17915
591365004648	ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124
591365004649	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
591365004650	Walker A/P-loop; other site
591365004651	ATP binding site [chemical binding]; other site
591365004652	Q-loop/lid; other site
591365004653	ABC transporter signature motif; other site
591365004654	Walker B; other site
591365004655	D-loop; other site
591365004656	H-loop/switch region; other site
591365004657	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352
591365004658	ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444
591365004659	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
591365004660	Walker A/P-loop; other site
591365004661	ATP binding site [chemical binding]; other site
591365004662	Q-loop/lid; other site
591365004663	ABC transporter signature motif; other site
591365004664	Walker B; other site
591365004665	D-loop; other site
591365004666	H-loop/switch region; other site
591365004667	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
591365004668	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173
591365004669	N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911
591365004670	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
591365004671	dimer interface [polypeptide binding]; other site
591365004672	conserved gate region; other site
591365004673	putative PBP binding loops; other site
591365004674	ABC-ATPase subunit interface; other site
591365004675	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
591365004676	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601
591365004677	dimer interface [polypeptide binding]; other site
591365004678	conserved gate region; other site
591365004679	putative PBP binding loops; other site
591365004680	ABC-ATPase subunit interface; other site
591365004681	ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166
591365004682	The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504
591365004683	peptide binding site [polypeptide binding]; other site
591365004684	ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166
591365004685	The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504
591365004686	peptide binding site [polypeptide binding]; other site
591365004687	Solo B3/4 domain (OB-fold DNA/RNA-binding) of Phe-aaRS-beta [General function prediction only]; Region: COG3382
591365004688	B3/4 domain; Region: B3_4; pfam03483
591365004689	CTP synthetase; Validated; Region: pyrG; PRK05380
591365004690	CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113
591365004691	Catalytic site [active]
591365004692	active site
591365004693	UTP binding site [chemical binding]; other site
591365004694	Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746
591365004695	active site
591365004696	putative oxyanion hole; other site
591365004697	catalytic triad [active]
591365004698	DNA-directed RNA polymerase delta subunit; Region: RNA_pol_delta; pfam05066
591365004699	trigger factor; Provisional; Region: tig; PRK01490
591365004700	FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254
591365004701	Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698
591365004702	hypothetical protein; Provisional; Region: PRK13690
591365004703	Predicted membrane protein [Function unknown]; Region: COG4720
591365004704	Protein of unknown function (DUF3816); Region: DUF3816; pfam12822
591365004705	4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169
591365004706	dimer interface [polypeptide binding]; other site
591365004707	substrate binding site [chemical binding]; other site
591365004708	ATP binding site [chemical binding]; other site
591365004709	tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021
591365004710	Eukaryotic and bacterial pseudouridine synthases similar to E.  coli TruA; Region: PseudoU_synth_EcTruA; cd02570
591365004711	dimerization interface 3.5A [polypeptide binding]; other site
591365004712	active site
591365004713	Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447
591365004714	nudix motif; other site
591365004715	chaperone protein DnaJ; Provisional; Region: PRK14276
591365004716	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257
591365004717	HSP70 interaction site [polypeptide binding]; other site
591365004718	C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cl03262
591365004719	substrate binding site [polypeptide binding]; other site
591365004720	Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719
591365004721	Zn binding sites [ion binding]; other site
591365004722	C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747
591365004723	dimer interface [polypeptide binding]; other site
591365004724	molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290
591365004725	Nucleotide-binding domain of human HSPA9 and similar proteins; Region: HSPA9-Ssq1-like_NBD; cd10234
591365004726	nucleotide binding site [chemical binding]; other site
591365004727	NEF interaction site [polypeptide binding]; other site
591365004728	SBD interface [polypeptide binding]; other site
591365004729	GrpE; Region: GrpE; pfam01025
591365004730	GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446
591365004731	dimer interface [polypeptide binding]; other site
591365004732	hsp70 (ATPase domain) interactions [polypeptide binding]; other site
591365004733	heat-inducible transcription repressor; Provisional; Region: hrcA; PRK00082
591365004734	Winged helix-turn-helix transcription repressor, HrcA DNA-binding; Region: HrcA_DNA-bdg; pfam03444
591365004735	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
591365004736	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
591365004737	Walker A/P-loop; other site
591365004738	ATP binding site [chemical binding]; other site
591365004739	Q-loop/lid; other site
591365004740	ABC transporter signature motif; other site
591365004741	Walker B; other site
591365004742	D-loop; other site
591365004743	H-loop/switch region; other site
591365004744	Protein of unknown function (DUF2812); Region: DUF2812; pfam11193
591365004745	Predicted transcriptional regulators [Transcription]; Region: COG1695
591365004746	Transcriptional regulator PadR-like family; Region: PadR; cl17335
591365004747	D-alanyl-D-alanine carboxypeptidase; Region: VanY; pfam02557
591365004748	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
591365004749	catalytic core [active]
591365004750	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
591365004751	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
591365004752	catalytic core [active]
591365004753	Uncharacterized proteins with similarity to Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL_like_DUF711; cd08025
591365004754	Transcriptional regulators [Transcription]; Region: PurR; COG1609
591365004755	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
591365004756	DNA binding site [nucleotide binding]
591365004757	domain linker motif; other site
591365004758	Ligand-binding domain of DNA transcription repressor RegR and other putative regulators such as KdgR and EndR; Region: PBP1_RegR_EndR_KdgR_like; cd06283
591365004759	putative dimerization interface [polypeptide binding]; other site
591365004760	putative ligand binding site [chemical binding]; other site
591365004761	Heparinase II/III-like protein; Region: Hepar_II_III; pfam07940
591365004762	Preprotein translocase subunit YajC [Intracellular trafficking and secretion]; Region: YajC; COG1862
591365004763	Phosphotransferase system, mannose/fructose/N-acetylgalactosamine-specific component IID [Carbohydrate transport and metabolism]; Region: ManZ; COG3716
591365004764	Phosphotransferase system, mannose/fructose/N-acetylgalactosamine-specific component IIC [Carbohydrate transport and metabolism]; Region: ManY; COG3715
591365004765	PTS_IIB, PTS system, Mannose/sorbose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_man; cd00001
591365004766	active site
591365004767	phosphorylation site [posttranslational modification]
591365004768	Glycosyl Hydrolase Family 88; Region: Glyco_hydro_88; pfam07470
591365004769	PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006
591365004770	active pocket/dimerization site; other site
591365004771	active site
591365004772	phosphorylation site [posttranslational modification]
591365004773	gluconate 5-dehydrogenase; Provisional; Region: PRK07097
591365004774	gluconate 5-dehydrogenase (Ga5DH)-like, classical (c) SDRs; Region: Ga5DH-like_SDR_c; cd05347
591365004775	NADP binding site [chemical binding]; other site
591365004776	homodimer interface [polypeptide binding]; other site
591365004777	active site
591365004778	hypothetical protein; Provisional; Region: PRK09273
591365004779	Ribose 5-phosphate isomerase RpiB [Carbohydrate transport and metabolism]; Region: RpiB; COG0698
591365004780	Ribose-5-phosphate isomerase; Region: DUF3666; pfam12408
591365004781	2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166
591365004782	Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524
591365004783	substrate binding site [chemical binding]; other site
591365004784	ATP binding site [chemical binding]; other site
591365004785	potential protein location (conserved hypothetical protein) that overlaps protein (PfkB family carbohydrate kinase)
591365004786	2-keto-3-deoxy-6-phosphogluconate aldolase [Carbohydrate transport and metabolism]; Region: Eda; COG0800
591365004787	KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452
591365004788	active site
591365004789	intersubunit interface [polypeptide binding]; other site
591365004790	catalytic residue [active]
591365004791	Cna protein B-type domain; Region: Cna_B; pfam05738
591365004792	Cna protein B-type domain; Region: Cna_B; pfam05738
591365004793	Repeat unit of collagen-binding protein domain B; Region: CollagenBindB; cd00222
591365004794	domain interaction interfaces [polypeptide binding]; other site
591365004795	Carbohydrate binding domain; Region: CBM_4_9; pfam02018
591365004796	Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; cl06814
591365004797	Glycosaminoglycan (GAG) polysaccharide lyase family. This family consists of a group of secreted bacterial lyase enzymes capable of acting on glycosaminoglycans, such as hyaluronan and chondroitin, in the extracellular matrix of host tissues; Region: GAG_Lyase; cd01083
591365004798	substrate binding site [chemical binding]; other site
591365004799	catalytic residues [active]
591365004800	Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per...; Region: GSH_Peroxidase; cd00340
591365004801	catalytic residues [active]
591365004802	dimer interface [polypeptide binding]; other site
591365004803	Membrane transport protein; Region: Mem_trans; cl09117
591365004804	malate dehydrogenase; Provisional; Region: PRK13529
591365004805	Malic enzyme, N-terminal domain; Region: malic; pfam00390
591365004806	NAD(P) binding domain of malic enzyme (ME), subgroup 1; Region: NAD_bind_1_malic_enz; cd05312
591365004807	NAD(P) binding site [chemical binding]; other site
591365004808	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
591365004809	non-specific DNA binding site [nucleotide binding]; other site
591365004810	salt bridge; other site
591365004811	sequence-specific DNA binding site [nucleotide binding]; other site
591365004812	Transcriptional regulator [Transcription]; Region: LysR; COG0583
591365004813	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
591365004814	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
591365004815	dimerization interface [polypeptide binding]; other site
591365004816	Domain of unknown function (DUF389); Region: DUF389; pfam04087
591365004817	Transposase; Region: DDE_Tnp_ISL3; pfam01610
591365004818	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464
591365004819	heavy metal translocating P-type ATPase; Region: ATPase-IB_hvy; TIGR01525
591365004820	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
591365004821	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
591365004822	motif II; other site
591365004823	MULE transposase domain; Region: MULE; pfam10551
591365004824	30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132
591365004825	Ribosomal protein L13.  Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392
591365004826	23S rRNA interface [nucleotide binding]; other site
591365004827	L3 interface [polypeptide binding]; other site
591365004828	EDD domain protein, DegV family; Region: DegV; TIGR00762
591365004829	Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645
591365004830	rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566
591365004831	RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032
591365004832	SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588
591365004833	glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650
591365004834	The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301
591365004835	Walker A/P-loop; other site
591365004836	ATP binding site [chemical binding]; other site
591365004837	Q-loop/lid; other site
591365004838	ABC transporter signature motif; other site
591365004839	Walker B; other site
591365004840	D-loop; other site
591365004841	H-loop/switch region; other site
591365004842	TOBE domain; Region: TOBE_2; pfam08402
591365004843	Regulator of polyketide synthase expression [Signal transduction mechanisms / Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2508
591365004844	PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556
591365004845	RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593
591365004846	active site
591365004847	metal binding site [ion binding]; metal-binding site
591365004848	dimerization interface [polypeptide binding]; other site
591365004849	cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260
591365004850	catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672
591365004851	active site
591365004852	HIGH motif; other site
591365004853	catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672
591365004854	KMSKS motif; other site
591365004855	Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020
591365004856	tRNA binding surface [nucleotide binding]; other site
591365004857	anticodon binding site; other site
591365004858	Phosphorylase superfamily; Region: PNP_UDP_1; pfam01048
591365004859	potential protein location (conserved hypothetical protein) that overlaps protein (uridine phosphorylase)
591365004860	Serine acetyltransferase [Amino acid transport and metabolism]; Region: CysE; COG1045
591365004861	Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354
591365004862	trimer interface [polypeptide binding]; other site
591365004863	active site
591365004864	substrate binding site [chemical binding]; other site
591365004865	CoA binding site [chemical binding]; other site
591365004866	polynucleotide phosphorylase/polyadenylase; Provisional; Region: PRK11824
591365004867	Polyribonucleotide nucleotidyltransferase, repeat 1; Region: RNase_PH_PNPase_1; cd11363
591365004868	RNase E interface [polypeptide binding]; other site
591365004869	trimer interface [polypeptide binding]; other site
591365004870	Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726
591365004871	Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364
591365004872	RNase E interface [polypeptide binding]; other site
591365004873	trimer interface [polypeptide binding]; other site
591365004874	active site
591365004875	Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393
591365004876	S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927
591365004877	RNA binding site [nucleotide binding]; other site
591365004878	oligoendopeptidase F; Region: pepF; TIGR00181
591365004879	Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins); Region: GluZincin; cl14813
591365004880	Zn binding site [ion binding]; other site
591365004881	Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353
591365004882	16S/18S rRNA binding site [nucleotide binding]; other site
591365004883	S13e-L30e interaction site [polypeptide binding]; other site
591365004884	25S rRNA binding site [nucleotide binding]; other site
591365004885	16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187
591365004886	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
591365004887	RNA binding surface [nucleotide binding]; other site
591365004888	Pseudouridine synthase, Escherichia coli RsuA like; Region: PseudoU_synth_RsuA; cd02553
591365004889	active site
591365004890	uracil binding [chemical binding]; other site
591365004891	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
591365004892	Major Facilitator Superfamily; Region: MFS_1; pfam07690
591365004893	putative substrate translocation pore; other site
591365004894	Polyphosphate(polyP) polymerase domain of yeast vacuolar transport chaperone (VTC) proteins VTC-2, -3 and- 4, and similar proteins; Region: PolyPPase_VTC_like; cd07750
591365004895	putative metal binding residues [ion binding]; other site
591365004896	signature motif; other site
591365004897	dimer interface [polypeptide binding]; other site
591365004898	active site
591365004899	polyP binding site; other site
591365004900	substrate binding site [chemical binding]; other site
591365004901	acceptor-phosphate pocket; other site
591365004902	CotH protein; Region: CotH; pfam08757
591365004903	Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063
591365004904	Interdomain contacts; other site
591365004905	Cytokine receptor motif; other site
591365004906	Predicted membrane protein [Function unknown]; Region: COG4267
591365004907	This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_3; cd03813
591365004908	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
591365004909	Uncharacterized protein conserved in bacteria (DUF2194); Region: DUF2194; pfam09960
591365004910	Putative NodB-like catalytic domain of uncharacterized proteins found in bacteria; Region: CE4_COG4878; cd10924
591365004911	NodB motif; other site
591365004912	putative active site [active]
591365004913	putative catalytic site [active]
591365004914	putative Zn binding site [ion binding]; other site
591365004915	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
591365004916	NAD(P) binding site [chemical binding]; other site
591365004917	active site
591365004918	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
591365004919	Domain of unknown function (DUF4118); Region: DUF4118; pfam13493
591365004920	Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487
591365004921	active site
591365004922	catalytic residues [active]
591365004923	metal binding site [ion binding]; metal-binding site
591365004924	Thermophilic metalloprotease (M29); Region: Peptidase_M29; pfam02073
591365004925	Leucyl aminopeptidase (aminopeptidase T) [Amino acid transport and metabolism]; Region: AmpS; COG2309
591365004926	DNA polymerase III PolC; Validated; Region: polC; PRK00448
591365004927	DNA polymerase III polC-type N-terminus; Region: DNA_pol3_alph_N; pfam11490
591365004928	polC_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold nucleic acid binding domain of Bacillus subtilis type C replicative DNA polymerase III alpha subunit (polC). Replication in B. subtilis and Staphylococcus aureus requires two...; Region: polC_OBF; cd04484
591365004929	generic binding surface II; other site
591365004930	generic binding surface I; other site
591365004931	Polymerase and Histidinol Phosphatase domain; Region: PHP; cl17102
591365004932	active site
591365004933	DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127
591365004934	active site
591365004935	catalytic site [active]
591365004936	substrate binding site [chemical binding]; other site
591365004937	Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III at PolC gene; Region: PHP_PolIIIA_POLC; cd07435
591365004938	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
591365004939	active site
591365004940	motif I; other site
591365004941	motif II; other site
591365004942	Gram-positive signal peptide, YSIRK family; Region: YSIRK_signal; TIGR01168
591365004943	pullulanase, extracellular, Gram-positive; Region: pullulan_Gpos; TIGR02102
591365004944	Family 41 Carbohydrate-Binding Module from pullulanase-like enzymes; Region: CBM41_pullulanase; cd10315
591365004945	carbohydrate binding site [chemical binding]; other site
591365004946	Family 41 Carbohydrate-Binding Module from pullulanase-like enzymes; Region: CBM41_pullulanase; cd10315
591365004947	carbohydrate binding site [chemical binding]; other site
591365004948	Early set domain associated with the catalytic domain of pullulanase (also called dextrinase and alpha-dextrin endo-1,6-alpha glucosidase); Region: E_set_Pullulanase; cd02860
591365004949	Alpha amylase catalytic domain found in Pullulanase (also called dextrinase; alpha-dextrin endo-1,6-alpha glucosidase), limit dextrinase, and related proteins; Region: AmyAc_Pullulanase_LD-like; cd11341
591365004950	Ca binding site [ion binding]; other site
591365004951	active site
591365004952	catalytic site [active]
591365004953	leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390
591365004954	catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812
591365004955	HIGH motif; other site
591365004956	Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603
591365004957	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
591365004958	active site
591365004959	KMSKS motif; other site
591365004960	Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958
591365004961	tRNA binding surface [nucleotide binding]; other site
591365004962	Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020
591365004963	potential protein location (conserved hypothetical protein) that overlaps protein (leucyl-tRNA synthetase)
591365004964	Predicted metalloendopeptidase [Posttranslational modification, protein turnover, chaperones]; Region: PepO; COG3590
591365004965	Peptidase family M13 includes neprilysin, endothelin-converting enzyme I; Region: M13; cd08662
591365004966	active site
591365004967	Zn binding site [ion binding]; other site
591365004968	Integrase core domain; Region: rve; pfam00665
591365004969	ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730
591365004970	ABC-2 family transporter protein; Region: ABC2_membrane_2; cl17866
591365004971	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
591365004972	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
591365004973	Walker A/P-loop; other site
591365004974	ATP binding site [chemical binding]; other site
591365004975	Q-loop/lid; other site
591365004976	ABC transporter signature motif; other site
591365004977	Walker B; other site
591365004978	D-loop; other site
591365004979	H-loop/switch region; other site
591365004980	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
591365004981	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
591365004982	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
591365004983	S-adenosylmethionine binding site [chemical binding]; other site
591365004984	Aminoglycoside 3-N-acetyltransferase; Region: Antibiotic_NAT; pfam02522
591365004985	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
591365004986	Coenzyme A binding pocket [chemical binding]; other site
591365004987	A predicted NlpC/p60-like peptidase; Region: BtrH; pfam14399
591365004988	Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various bacteriocins (mostly non-lantibiotic); Region: Peptidase_C39_like; cl00296
591365004989	Predicted transcriptional regulators [Transcription]; Region: COG1695
591365004990	Transcriptional regulator PadR-like family; Region: PadR; cl17335
591365004991	GyrI-like small molecule binding domain; Region: GyrI-like; cl01368
591365004992	ABC-2 family transporter protein; Region: ABC2_membrane_5; pfam13346
591365004993	ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555
591365004994	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
591365004995	Walker A/P-loop; other site
591365004996	ATP binding site [chemical binding]; other site
591365004997	Q-loop/lid; other site
591365004998	ABC transporter signature motif; other site
591365004999	Walker B; other site
591365005000	D-loop; other site
591365005001	H-loop/switch region; other site
591365005002	Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940
591365005003	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037
591365005004	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
591365005005	Major Facilitator Superfamily; Region: MFS_1; pfam07690
591365005006	putative substrate translocation pore; other site
591365005007	Flavodoxin-like fold; Region: Flavodoxin_2; pfam02525
591365005008	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632
591365005009	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
591365005010	active site
591365005011	metal binding site [ion binding]; metal-binding site
591365005012	Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403
591365005013	active site
591365005014	NTP binding site [chemical binding]; other site
591365005015	metal binding triad [ion binding]; metal-binding site
591365005016	Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826
591365005017	Integrase core domain; Region: rve; pfam00665
591365005018	ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121
591365005019	ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235
591365005020	ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108
591365005021	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
591365005022	ABC-ATPase subunit  interface; other site
591365005023	dimer interface [polypeptide binding]; other site
591365005024	putative PBP binding regions; other site
591365005025	ABC-type metal ion transport system, periplasmic component/surface adhesin [Inorganic ion transport and metabolism]; Region: LraI; COG0803
591365005026	Metal binding protein PsaA.  These proteins have been shown to function as initial receptors in ABC transport of Mn2+ and as surface adhesins in some eubacterial species.  They belong to the TroA superfamily of periplasmic metal binding proteins that...; Region: PsaA; cd01137
591365005027	metal binding site [ion binding]; metal-binding site
591365005028	Mn-dependent transcriptional regulator [Transcription]; Region: TroR; COG1321
591365005029	Iron dependent repressor, N-terminal DNA binding domain; Region: Fe_dep_repress; pfam01325
591365005030	Iron dependent repressor, metal binding and dimerisation domain; Region: Fe_dep_repr_C; pfam02742
591365005031	FeoA domain; Region: FeoA; pfam04023
591365005032	D-Tyrosyl-tRNAtyr deacylases; a class of tRNA-dependent hydrolases which are capable of hydrolyzing the ester bond of D-Tyrosyl-tRNA reducing the level of cellular D-Tyrosine while recycling the peptidyl-tRNA; found in bacteria and in eukaryotes but not...; Region: Dtyr_deacylase; cd00563
591365005033	putative active site [active]
591365005034	dimerization interface [polypeptide binding]; other site
591365005035	putative tRNAtyr binding site [nucleotide binding]; other site
591365005036	Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317
591365005037	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
591365005038	Zn2+ binding site [ion binding]; other site
591365005039	Mg2+ binding site [ion binding]; other site
591365005040	Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399
591365005041	synthetase active site [active]
591365005042	NTP binding site [chemical binding]; other site
591365005043	metal binding site [ion binding]; metal-binding site
591365005044	TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668
591365005045	ACT  domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876
591365005046	16S ribosomal RNA methyltransferase RsmE; Provisional; Region: PRK11713
591365005047	RNA methyltransferase, RsmE family; Region: TIGR00046
591365005048	Ribosomal protein L11 methyltransferase (PrmA); Region: PrmA; pfam06325
591365005049	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
591365005050	S-adenosylmethionine binding site [chemical binding]; other site
591365005051	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
591365005052	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
591365005053	Coenzyme A binding pocket [chemical binding]; other site
591365005054	Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_23; cd04682
591365005055	nudix motif; other site
591365005056	Protein of unknown function (DUF3013); Region: DUF3013; pfam11217
591365005057	recombination factor protein RarA; Reviewed; Region: PRK13342
591365005058	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
591365005059	Walker A motif; other site
591365005060	ATP binding site [chemical binding]; other site
591365005061	Walker B motif; other site
591365005062	arginine finger; other site
591365005063	MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002
591365005064	The (Largely Archaeal Putative) Hydrophobe/Amphiphile Efflux-3 (HAE3) Family; Region: 2A067; TIGR00921
591365005065	Predicted transcriptional regulator [Transcription]; Region: COG1959
591365005066	Transcriptional regulator; Region: Rrf2; pfam02082
591365005067	NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604
591365005068	alcohol dehydrogenase and quinone reductase-like medium chain degydrogenases/reductases; Region: MDR_like_2; cd05289
591365005069	putative NAD(P) binding site [chemical binding]; other site
591365005070	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
591365005071	TAP-like protein; Region: Abhydrolase_4; pfam08386
591365005072	dihydromonapterin reductase; Provisional; Region: PRK06483
591365005073	retinol dehydrogenase (retinol-DH), Light dependent Protochlorophyllide (Pchlide) OxidoReductase (LPOR) and related proteins, classical (c) SDRs; Region: retinol-DH_like_SDR_c_like; cd05327
591365005074	putative NAD(P) binding site [chemical binding]; other site
591365005075	active site
591365005076	Predicted thioesterase involved in non-ribosomal peptide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: GrsT; COG3208
591365005077	Lipase.  Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is "interfacial activation", the process of...; Region: Lipase; cl14883
591365005078	Phosphopantetheinyl transferase [Coenzyme metabolism]; Region: Sfp; COG2091
591365005079	4'-phosphopantetheinyl transferase superfamily; Region: ACPS; pfam01648
591365005080	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
591365005081	ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577
591365005082	FtsX-like permease family; Region: FtsX; pfam02687
591365005083	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
591365005084	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
591365005085	Walker A/P-loop; other site
591365005086	ATP binding site [chemical binding]; other site
591365005087	Q-loop/lid; other site
591365005088	ABC transporter signature motif; other site
591365005089	Walker B; other site
591365005090	D-loop; other site
591365005091	H-loop/switch region; other site
591365005092	Condensation domain; Region: Condensation; pfam00668
591365005093	Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020
591365005094	The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930
591365005095	acyl-activating enzyme (AAE) consensus motif; other site
591365005096	AMP binding site [chemical binding]; other site
591365005097	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
591365005098	Condensation domain; Region: Condensation; pfam00668
591365005099	Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020
591365005100	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
591365005101	Condensation domain; Region: Condensation; pfam00668
591365005102	Wax ester synthase-like Acyl-CoA acyltransferase domain; Region: WES_acyltransf; pfam03007
591365005103	The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930
591365005104	amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733
591365005105	acyl-activating enzyme (AAE) consensus motif; other site
591365005106	AMP binding site [chemical binding]; other site
591365005107	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
591365005108	Predicted transcriptional regulator [Transcription]; Region: COG1959
591365005109	Transcriptional regulator; Region: Rrf2; pfam02082
591365005110	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1636
591365005111	chaperonin GroEL; Reviewed; Region: groEL; PRK12849
591365005112	GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344
591365005113	ring oligomerisation interface [polypeptide binding]; other site
591365005114	ATP/Mg binding site [chemical binding]; other site
591365005115	stacking interactions; other site
591365005116	hinge regions; other site
591365005117	Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320
591365005118	oligomerisation interface [polypeptide binding]; other site
591365005119	mobile loop; other site
591365005120	roof hairpin; other site
591365005121	PTS system mannose/fructose/sorbose family IID component; Region: EIID-AGA; pfam03613
591365005122	PTS system sorbose-specific iic component; Region: EII-Sor; pfam03609
591365005123	PTS system sorbose subfamily IIB component; Region: PTSIIB_sorb; pfam03830
591365005124	active site
591365005125	phosphorylation site [posttranslational modification]
591365005126	PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cl00025
591365005127	active site
591365005128	active pocket/dimerization site; other site
591365005129	phosphorylation site [posttranslational modification]
591365005130	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
591365005131	Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416
591365005132	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
591365005133	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
591365005134	active site
591365005135	phosphorylation site [posttranslational modification]
591365005136	intermolecular recognition site; other site
591365005137	dimerization interface [polypeptide binding]; other site
591365005138	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
591365005139	DNA binding residues [nucleotide binding]
591365005140	dimerization interface [polypeptide binding]; other site
591365005141	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585
591365005142	Histidine kinase; Region: HisKA_3; pfam07730
591365005143	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
591365005144	ATP binding site [chemical binding]; other site
591365005145	Mg2+ binding site [ion binding]; other site
591365005146	G-X-G motif; other site
591365005147	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: RbsB; COG1879
591365005148	Periplasmic sugar-binding domain of active transport systems that are members of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_sugar_binding_like; cd01536
591365005149	ligand binding site [chemical binding]; other site
591365005150	Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629
591365005151	SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496
591365005152	dimer interface [polypeptide binding]; other site
591365005153	ssDNA binding site [nucleotide binding]; other site
591365005154	tetramer (dimer of dimers) interface [polypeptide binding]; other site
591365005155	tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain.  PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796
591365005156	putative tRNA-binding site [nucleotide binding]; other site
591365005157	TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947
591365005158	catalytic residues [active]
591365005159	Cellulase M and related proteins [Carbohydrate transport and metabolism]; Region: FrvX; COG1363
591365005160	M42 Peptidases, also known as glutamyl aminopeptidase family; Region: M42; cd05638
591365005161	oligomer interface [polypeptide binding]; other site
591365005162	active site
591365005163	metal binding site [ion binding]; metal-binding site
591365005164	ECF-type riboflavin transporter, S component; Region: ECF-ribofla_trS; cl17272
591365005165	Protein of unknown function (DUF3816); Region: DUF3816; pfam12822
591365005166	Folylpolyglutamate synthase [Coenzyme metabolism]; Region: FolC; COG0285
591365005167	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
591365005168	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
591365005169	prolyl-tRNA synthetase; Provisional; Region: PRK09194
591365005170	Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_prok; cd00779
591365005171	dimer interface [polypeptide binding]; other site
591365005172	motif 1; other site
591365005173	active site
591365005174	motif 2; other site
591365005175	INS is an amino acid-editing domain inserted (INS) into the bacterial class II prolyl-tRNA synthetase (ProRS) however, this CD is not exclusively bacterial. It is also found at the N-terminus of the eukaryotic/archaea-like ProRS's of yeasts and...; Region: ProRS-INS; cd04334
591365005176	putative deacylase active site [active]
591365005177	Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA.   PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268
591365005178	active site
591365005179	motif 3; other site
591365005180	ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding; Region: ProRS_anticodon_short; cd00861
591365005181	anticodon binding site; other site
591365005182	RIP metalloprotease RseP; Region: TIGR00054
591365005183	RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163
591365005184	active site
591365005185	Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020
591365005186	PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989
591365005187	protein binding site [polypeptide binding]; other site
591365005188	RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163
591365005189	putative substrate binding region [chemical binding]; other site
591365005190	CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575
591365005191	Cytidylyltransferase family; Region: CTP_transf_1; pfam01148
591365005192	Undecaprenyl pyrophosphate synthase [Lipid metabolism]; Region: UppS; COG0020
591365005193	Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cd00475
591365005194	catalytic residue [active]
591365005195	putative FPP diphosphate  binding site; other site
591365005196	putative FPP binding hydrophobic cleft; other site
591365005197	dimer interface [polypeptide binding]; other site
591365005198	putative IPP diphosphate binding site; other site
591365005199	preprotein translocase subunit YajC; Validated; Region: yajC; PRK06531
591365005200	Transketolase [Carbohydrate transport and metabolism]; Region: TktA; COG0021
591365005201	Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012
591365005202	TPP-binding site [chemical binding]; other site
591365005203	dimer interface [polypeptide binding]; other site
591365005204	Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033
591365005205	PYR/PP interface [polypeptide binding]; other site
591365005206	dimer interface [polypeptide binding]; other site
591365005207	TPP binding site [chemical binding]; other site
591365005208	putative L-ascorbate 6-phosphate lactonase; Provisional; Region: PRK11709
591365005209	Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220
591365005210	Transcriptional antiterminator [Transcription]; Region: BglG; COG3711
591365005211	PRD domain; Region: PRD; pfam00874
591365005212	PRD domain; Region: PRD; pfam00874
591365005213	PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568
591365005214	active site
591365005215	P-loop; other site
591365005216	phosphorylation site [posttranslational modification]
591365005217	putative L-xylulose 5-phosphate 3-epimerase; Reviewed; Region: PRK13210
591365005218	AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cd00019
591365005219	AP (apurinic/apyrimidinic) site pocket; other site
591365005220	DNA interaction; other site
591365005221	Metal-binding active site; metal-binding site
591365005222	3-Keto-L-gulonate 6-phosphate decarboxylase (KGPDC) and D-arabino-3-hexulose-6-phosphate synthase (HPS). KGPDC catalyzes the formation of L-xylulose 5-phosphate and carbon dioxide from 3-keto-L-gulonate 6-phosphate as part of the anaerobic pathway for...; Region: KGPDC_HPS; cd04726
591365005223	active site
591365005224	dimer interface [polypeptide binding]; other site
591365005225	magnesium binding site [ion binding]; other site
591365005226	PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211
591365005227	active site
591365005228	phosphorylation site [posttranslational modification]
591365005229	PTS system ascorbate-specific transporter subunit IIC; Reviewed; Region: PRK12997
591365005230	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
591365005231	ATPases associated with a variety of cellular activities; Region: AAA; smart00382
591365005232	Walker A motif; other site
591365005233	ATP binding site [chemical binding]; other site
591365005234	Walker B motif; other site
591365005235	arginine finger; other site
591365005236	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
591365005237	Walker A motif; other site
591365005238	ATP binding site [chemical binding]; other site
591365005239	Walker B motif; other site
591365005240	arginine finger; other site
591365005241	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431
591365005242	glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331
591365005243	Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans).  The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714
591365005244	glutaminase active site [active]
591365005245	SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008
591365005246	dimer interface [polypeptide binding]; other site
591365005247	active site
591365005248	SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009
591365005249	dimer interface [polypeptide binding]; other site
591365005250	active site
591365005251	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012
591365005252	propionate/acetate kinase; Provisional; Region: PRK12379
591365005253	nucleotide binding site [chemical binding]; other site
591365005254	butyrate kinase; Provisional; Region: PRK03011
591365005255	Adenine-specific DNA methylase [DNA replication, recombination, and repair]; Region: COG0827
591365005256	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
591365005257	S-adenosylmethionine binding site [chemical binding]; other site
591365005258	Competence protein ComGF [Intracellular trafficking and secretion]; Region: ComGF; COG4940
591365005259	Type II secretory pathway pseudopilin; Region: PulG; pfam11773
591365005260	Competence protein ComGC [Intracellular trafficking and secretion]; Region: ComGC; COG4537
591365005261	Type II secretory pathway, component PulF [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulF; COG1459
591365005262	Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482
591365005263	Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482
591365005264	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
591365005265	Walker A motif; other site
591365005266	ATP binding site [chemical binding]; other site
591365005267	Walker B motif; other site
591365005268	Protein of unknown function (DUF1033); Region: DUF1033; pfam06279
591365005269	Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174
591365005270	Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951
591365005271	Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120
591365005272	Helix-Turn-Helix DNA binding domain of GlnR-like transcription regulators; Region: HTH_GlnR-like; cd01105
591365005273	MerR HTH family regulatory protein; Region: MerR_1; pfam13411
591365005274	DNA binding residues [nucleotide binding]
591365005275	putative dimer interface [polypeptide binding]; other site
591365005276	Bacterial protein of unknown function (DUF939); Region: DUF939; pfam06081
591365005277	Predicted membrane protein [Function unknown]; Region: COG4129
591365005278	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
591365005279	Surface antigen [General function prediction only]; Region: COG3942
591365005280	CHAP domain; Region: CHAP; pfam05257
591365005281	Streptococcal surface antigen repeat; Region: Strep_SA_rep; pfam06696
591365005282	Streptococcal surface antigen repeat; Region: Strep_SA_rep; pfam06696
591365005283	Glucan-binding protein C; Region: GbpC; pfam08363
591365005284	adhesin isopeptide-forming domain, sspB-C2 type; Region: isopep_sspB_C2; TIGR04228
591365005285	Gram positive anchor; Region: Gram_pos_anchor; pfam00746
591365005286	phosphoglycerate kinase; Provisional; Region: pgk; PRK00073
591365005287	Phosphoglycerate kinase; Region: PGK; pfam00162
591365005288	substrate binding site [chemical binding]; other site
591365005289	hinge regions; other site
591365005290	ADP binding site [chemical binding]; other site
591365005291	catalytic site [active]
591365005292	DNA-directed RNA polymerase subunit beta'; Provisional; Region: PRK00566
591365005293	RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997
591365005294	RNA polymerase I subunit A N-terminus; Region: RPOLA_N; smart00663
591365005295	RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983
591365005296	RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000
591365005297	Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655
591365005298	Rpb1 (beta') - Rpb6 (omega) interaction site [polypeptide binding]; other site
591365005299	G-loop; other site
591365005300	Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655
591365005301	DNA binding site [nucleotide binding]
591365005302	Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site
591365005303	RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585
591365005304	RNA polymerase Rpb2, domain 2; Region: RNA_pol_Rpb2_2; pfam04561
591365005305	DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405
591365005306	RNA polymerase Rpb2, domain 2; Region: RNA_pol_Rpb2_2; pfam04561
591365005307	RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653
591365005308	RPB1 interaction site [polypeptide binding]; other site
591365005309	RPB10 interaction site [polypeptide binding]; other site
591365005310	RPB11 interaction site [polypeptide binding]; other site
591365005311	RPB3 interaction site [polypeptide binding]; other site
591365005312	RPB12 interaction site [polypeptide binding]; other site
591365005313	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
591365005314	putative bacteriocin export ABC transporter, lactococcin 972 group; Region: L_ocin_972_ABC; TIGR03608
591365005315	Walker A/P-loop; other site
591365005316	ATP binding site [chemical binding]; other site
591365005317	Q-loop/lid; other site
591365005318	ABC transporter signature motif; other site
591365005319	Walker B; other site
591365005320	D-loop; other site
591365005321	H-loop/switch region; other site
591365005322	bacteriocin-associated integral membrane (putative immunity) protein; Region: bact_immun_7tm; TIGR01654
591365005323	Protein of unknown function (DUF1430); Region: DUF1430; pfam07242
591365005324	penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074
591365005325	Transglycosylase; Region: Transgly; pfam00912
591365005326	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760
591365005327	tyrosyl-tRNA synthetase; Validated; Region: PRK05912
591365005328	catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805
591365005329	active site
591365005330	HIGH motif; other site
591365005331	dimer interface [polypeptide binding]; other site
591365005332	KMSKS motif; other site
591365005333	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
591365005334	RNA binding surface [nucleotide binding]; other site
591365005335	23S rRNA methyltransferase A; Provisional; Region: rrmA; PRK11088
591365005336	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
591365005337	S-adenosylmethionine binding site [chemical binding]; other site
591365005338	Rhomboid family; Region: Rhomboid; pfam01694
591365005339	5,10-methenyltetrahydrofolate synthetase; Region: MTHFS_bact; TIGR02727
591365005340	5-formyltetrahydrofolate cyclo-ligase family; Region: 5-FTHF_cyc-lig; pfam01812
591365005341	M20 Peptidase Aminoacyclase-1 YkuR-like proteins, including YkuR and Ama/HipO/HyuC proteins; Region: M20_Acy1_YkuR_like; cd05670
591365005342	Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473
591365005343	metal binding site [ion binding]; metal-binding site
591365005344	putative dimer interface [polypeptide binding]; other site
591365005345	Tetrahydrodipicolinate succinyltransferase N-terminal; Region: DapH_N; pfam08503
591365005346	2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-acetyltransferase; Region: DapD_Ac; TIGR03532
591365005347	2,3,4,5-tetrahydropyridine-2,6-dicarboxylate (THDP) N-succinyltransferase (also called THP succinyltransferase): THDP N-succinyltransferase catalyzes the conversion of tetrahydrodipicolinate and succinyl-CoA to N-succinyltetrahydrodipicolinate and CoA; Region: LbH_THP_succinylT; cd03350
591365005348	trimer interface [polypeptide binding]; other site
591365005349	active site
591365005350	substrate binding site [chemical binding]; other site
591365005351	CoA binding site [chemical binding]; other site
591365005352	glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406
591365005353	catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808
591365005354	active site
591365005355	HIGH motif; other site
591365005356	catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808
591365005357	active site
591365005358	KMSKS motif; other site
591365005359	DNA repair protein RadA; Provisional; Region: PRK11823
591365005360	Sms (bacterial radA) DNA repair protein. This protein is not related to archael radA any more than is to other RecA-like NTPases. Sms has a role in recombination and recombinational repair and is responsible for the stabilization or processing of...; Region: Sms; cd01121
591365005361	Walker A motif/ATP binding site; other site
591365005362	ATP binding site [chemical binding]; other site
591365005363	Walker B motif; other site
591365005364	Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541
591365005365	Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431
591365005366	catalytic triad [active]
591365005367	conserved cis-peptide bond; other site
591365005368	Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557
591365005369	trimer interface [polypeptide binding]; other site
591365005370	active site
591365005371	Microcin C7 self-immunity protein determines resistance to exogenous microcin C7; Region: Peptidase_S66_mccF_like; cd07062
591365005372	putative dimer interface [polypeptide binding]; other site
591365005373	catalytic triad [active]
591365005374	NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094
591365005375	NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210
591365005376	NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479
591365005377	Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541
591365005378	dTDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: RfbA; COG1209
591365005379	active site
591365005380	tetramer interface; other site
591365005381	Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381
591365005382	Predicted transcriptional regulators [Transcription]; Region: COG1733
591365005383	HxlR-like helix-turn-helix; Region: HxlR; pfam01638
591365005384	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
591365005385	DNA binding site [nucleotide binding]
591365005386	active site
591365005387	Int/Topo IB signature motif; other site
591365005388	50S ribosomal protein L17; Validated; Region: rplQ; PRK05591
591365005389	DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182
591365005390	N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928
591365005391	alphaNTD homodimer interface [polypeptide binding]; other site
591365005392	alphaNTD - beta interaction site [polypeptide binding]; other site
591365005393	alphaNTD - beta' interaction site [polypeptide binding]; other site
591365005394	Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118
591365005395	30S ribosomal protein S11; Validated; Region: PRK05309
591365005396	Ribosomal protein S13 [Translation, ribosomal structure and biogenesis]; Region: RpsM; COG0099
591365005397	30S ribosomal protein S13; Region: bact_S13; TIGR03631
591365005398	Ribosomal protein L36; Region: Ribosomal_L36; pfam00444
591365005399	S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451
591365005400	rRNA binding site [nucleotide binding]; other site
591365005401	predicted 30S ribosome binding site; other site
591365005402	adenylate kinase; Reviewed; Region: adk; PRK00279
591365005403	Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428
591365005404	AMP-binding site [chemical binding]; other site
591365005405	ATP-AMP (Ap5A)-binding site [chemical binding]; other site
591365005406	preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204
591365005407	SecY translocase; Region: SecY; pfam00344
591365005408	50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592
591365005409	Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins that...; Region: Ribosomal_L30; cd01658
591365005410	23S rRNA binding site [nucleotide binding]; other site
591365005411	30S ribosomal protein S5; Validated; Region: rpsE; PRK00550
591365005412	Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333
591365005413	Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719
591365005414	Ribosomal L18/L5e:  L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432
591365005415	5S rRNA interface [nucleotide binding]; other site
591365005416	L27 interface [polypeptide binding]; other site
591365005417	23S rRNA interface [nucleotide binding]; other site
591365005418	L5 interface [polypeptide binding]; other site
591365005419	50S ribosomal protein L6; Validated; Region: rplF; PRK05498
591365005420	Ribosomal protein L6; Region: Ribosomal_L6; pfam00347
591365005421	Ribosomal protein L6; Region: Ribosomal_L6; pfam00347
591365005422	30S ribosomal protein S8; Validated; Region: rpsH; PRK00136
591365005423	30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08061
591365005424	50S ribosomal protein L5; Validated; Region: rplE; PRK00010
591365005425	Ribosomal protein L5; Region: Ribosomal_L5; pfam00281
591365005426	ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673
591365005427	50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004
591365005428	KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089
591365005429	RNA binding site [nucleotide binding]; other site
591365005430	50S ribosomal protein L14; Validated; Region: rplN; PRK05483
591365005431	30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610
591365005432	Ribosomal L29 protein/HIP.  L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals.  L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427
591365005433	23S rRNA interface [nucleotide binding]; other site
591365005434	putative translocon interaction site; other site
591365005435	signal recognition particle (SRP54) interaction site; other site
591365005436	L23 interface [polypeptide binding]; other site
591365005437	trigger factor interaction site; other site
591365005438	Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433
591365005439	23S rRNA interface [nucleotide binding]; other site
591365005440	5S rRNA interface [nucleotide binding]; other site
591365005441	putative antibiotic binding site [chemical binding]; other site
591365005442	L25 interface [polypeptide binding]; other site
591365005443	L27 interface [polypeptide binding]; other site
591365005444	30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310
591365005445	K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3  is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel.  The KH...; Region: 30S_S3_KH; cd02412
591365005446	G-X-X-G motif; other site
591365005447	Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189
591365005448	Ribosomal protein L22/L17e.  L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit.  It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336
591365005449	putative translocon binding site; other site
591365005450	protein-rRNA interface [nucleotide binding]; other site
591365005451	30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357
591365005452	50S ribosomal protein L2; Validated; Region: rplB; PRK09374
591365005453	Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181
591365005454	Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947
591365005455	50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738
591365005456	50S ribosomal protein L4; Provisional; Region: rplD; PRK05319
591365005457	50S ribosomal protein L3; Validated; Region: rplC; PRK00001
591365005458	30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596
591365005459	Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190
591365005460	active site
591365005461	queuine tRNA-ribosyltransferase; Provisional; Region: tgt; PRK00112
591365005462	Queuine/archaeosine tRNA-ribosyltransferase [Translation, ribosomal structure and biogenesis]; Region: Tgt; COG0343
591365005463	Protein of unknown function (DUF975); Region: DUF975; cl10504
591365005464	hypothetical protein; Provisional; Region: PRK06762
591365005465	Predicted CoA-binding protein [General function prediction only]; Region: COG1832
591365005466	DNA polymerase I; Provisional; Region: PRK05755
591365005467	PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859
591365005468	active site
591365005469	metal binding site 1 [ion binding]; metal-binding site
591365005470	putative 5' ssDNA interaction site; other site
591365005471	metal binding site 3; metal-binding site
591365005472	metal binding site 2 [ion binding]; metal-binding site
591365005473	H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898
591365005474	putative DNA binding site [nucleotide binding]; other site
591365005475	putative metal binding site [ion binding]; other site
591365005476	inactive DEDDy 3'-5' exonuclease domain of Bacillus stearothermophilus DNA polymerase I and similar family-A DNA polymerases; Region: DNA_polA_I_Bacillus_like_exo; cd06140
591365005477	Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637
591365005478	active site
591365005479	DNA binding site [nucleotide binding]
591365005480	catalytic site [active]
591365005481	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
591365005482	catalytic core [active]
591365005483	YcxB-like protein; Region: YcxB; pfam14317
591365005484	haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282
591365005485	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cl17915
591365005486	Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263
591365005487	bifunctional PTS system maltose and glucose-specific transporter subunits IICB; Provisional; Region: PRK10110
591365005488	PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212
591365005489	active site turn [active]
591365005490	phosphorylation site [posttranslational modification]
591365005491	transcriptional regulator MurR; Provisional; Region: PRK15482
591365005492	Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418
591365005493	RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013
591365005494	putative active site [active]
591365005495	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
591365005496	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
591365005497	dimer interface [polypeptide binding]; other site
591365005498	phosphorylation site [posttranslational modification]
591365005499	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
591365005500	ATP binding site [chemical binding]; other site
591365005501	Mg2+ binding site [ion binding]; other site
591365005502	G-X-G motif; other site
591365005503	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
591365005504	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
591365005505	active site
591365005506	phosphorylation site [posttranslational modification]
591365005507	intermolecular recognition site; other site
591365005508	dimerization interface [polypeptide binding]; other site
591365005509	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
591365005510	DNA binding site [nucleotide binding]
591365005511	Fibronectin-binding repeat; Region: SSURE; pfam11966
591365005512	Fibronectin-binding repeat; Region: SSURE; pfam11966
591365005513	Fibronectin-binding repeat; Region: SSURE; pfam11966
591365005514	Fibronectin-binding repeat; Region: SSURE; pfam11966
591365005515	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
591365005516	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761
591365005517	active site
591365005518	This family is most closely related to the GT1 family of glycosyltransferases. cap1E in Streptococcus pneumoniae is required for the synthesis of type 1 capsular polysaccharides; Region: GT1_cap1E_like; cd03808
591365005519	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
591365005520	putative ADP-binding pocket [chemical binding]; other site
591365005521	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
591365005522	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
591365005523	NAD(P) binding site [chemical binding]; other site
591365005524	active site
591365005525	Bacterial sugar transferase; Region: Bac_transf; pfam02397
591365005526	Predicted nucleoside-diphosphate sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG1086
591365005527	UDP-Glcnac (UDP-linked N-acetylglucosamine) inverting 4,6-dehydratase, extended (e) SDRs; Region: UDP_invert_4-6DH_SDR_e; cd05237
591365005528	NAD(P) binding site [chemical binding]; other site
591365005529	homodimer interface [polypeptide binding]; other site
591365005530	substrate binding site [chemical binding]; other site
591365005531	active site
591365005532	capsular exopolysaccharide family; Region: eps_fam; TIGR01007
591365005533	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
591365005534	polysaccharide export protein, MPA1 family, Gram-positive type; Region: polys_exp_MPA1; TIGR01006
591365005535	Capsular polysaccharide biosynthesis protein [Cell envelope biogenesis, outer membrane]; Region: COG3944
591365005536	Capsular polysaccharide biosynthesis protein [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: CapC; COG4464
591365005537	DNA polymerase processivity factor; Region: DNA_PPF; pfam02916
591365005538	Cell envelope-related transcriptional attenuator domain; Region: LytR_cpsA_psr; pfam03816
591365005539	4Fe-4S single cluster domain; Region: Fer4_12; pfam13353
591365005540	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
591365005541	FeS/SAM binding site; other site
591365005542	Predicted acetyltransferase [General function prediction only]; Region: COG3981
591365005543	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
591365005544	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
591365005545	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
591365005546	Coenzyme A binding pocket [chemical binding]; other site
591365005547	anaerobic ribonucleoside triphosphate reductase; Provisional; Region: PRK09263
591365005548	ATP cone domain; Region: ATP-cone; pfam03477
591365005549	Class III ribonucleotide reductase; Region: RNR_III; cd01675
591365005550	effector binding site; other site
591365005551	active site
591365005552	Zn binding site [ion binding]; other site
591365005553	glycine loop; other site
591365005554	Predicted integral membrane protein [Function unknown]; Region: COG5617
591365005555	Phospholipase_D-nuclease N-terminal; Region: PLDc_N; pfam13396
591365005556	Phosphatidylserine/phosphatidylglycerophosphate/car diolipin synthases and related enzymes [Lipid metabolism]; Region: Cls; COG1502
591365005557	Putative catalytic domain, repeat 1, of Streptococcus mutans uncharacterized protein SMU_988 and similar proteins; Region: PLDc_SMU_988_like_1; cd09154
591365005558	putative active site [active]
591365005559	catalytic site [active]
591365005560	Putative catalytic domain, repeat 2, of Streptococcus mutans uncharacterized protein SMU_988 and similar proteins; Region: PLDc_SMU_988_like_2; cd09160
591365005561	putative active site [active]
591365005562	catalytic site [active]
591365005563	Bacterial lipoprotein; Region: DUF3642; pfam12182
591365005564	folylpolyglutamate synthase/dihydrofolate synthase; Region: folC; TIGR01499
591365005565	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
591365005566	hypothetical protein; Provisional; Region: PRK13678
591365005567	Holliday junction resolvase-like protein; Reviewed; Region: PRK00109
591365005568	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4472
591365005569	Protein of unknown function (DUF1307); Region: DUF1307; cl01981
591365005570	Arsenate Reductase (ArsC) family, Spx subfamily; Spx is a unique RNA polymerase (RNAP)-binding protein present in bacilli and some mollicutes. It inhibits transcription by binding to the C-terminal domain of the alpha subunit of RNAP, disrupting complex...; Region: ArsC_Spx; cd03032
591365005571	ArsC family; Region: ArsC; pfam03960
591365005572	putative catalytic residues [active]
591365005573	thiol/disulfide switch; other site
591365005574	recombinase A; Provisional; Region: recA; PRK09354
591365005575	RecA is a  bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response.  RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983
591365005576	hexamer interface [polypeptide binding]; other site
591365005577	Walker A motif; other site
591365005578	ATP binding site [chemical binding]; other site
591365005579	Walker B motif; other site
591365005580	competence damage-inducible protein A; Provisional; Region: PRK00549
591365005581	Competence-damaged protein. CinA is the first gene in the competence- inducible (cin) operon and is thought to be specifically required at some stage in the process of transformation. This domain is closely related to a domain, found in a variety of...; Region: cinA; cd00885
591365005582	putative MPT binding site; other site
591365005583	Uncharacterized protein (competence- and mitomycin-induced) [General function prediction only]; Region: CinA; COG1546
591365005584	Cna protein B-type domain; Region: Cna_B; pfam05738
591365005585	Repeat unit of collagen-binding protein domain B; Region: CollagenBindB; cd00222
591365005586	domain interaction interfaces [polypeptide binding]; other site
591365005587	streptococcal pilin isopeptide linkage domain; Region: strep_pil_rpt; TIGR03786
591365005588	Repeat unit of collagen-binding protein domain B; Region: CollagenBindB; cd00222
591365005589	domain interaction interfaces [polypeptide binding]; other site
591365005590	Repeat unit of collagen-binding protein domain B; Region: CollagenBindB; cd00222
591365005591	domain interaction interfaces [polypeptide binding]; other site
591365005592	Repeat unit of collagen-binding protein domain B; Region: CollagenBindB; cd00222
591365005593	domain interaction interfaces [polypeptide binding]; other site
591365005594	Repeat unit of collagen-binding protein domain B; Region: CollagenBindB; cd00222
591365005595	domain interaction interfaces [polypeptide binding]; other site
591365005596	Repeat unit of collagen-binding protein domain B; Region: CollagenBindB; cd00222
591365005597	domain interaction interfaces [polypeptide binding]; other site
591365005598	Repeat unit of collagen-binding protein domain B; Region: CollagenBindB; cd00222
591365005599	domain interaction interfaces [polypeptide binding]; other site
591365005600	CAAX protease self-immunity; Region: Abi; pfam02517
591365005601	Methyladenine glycosylase; Region: Adenine_glyco; pfam03352
591365005602	Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116
591365005603	RuvA N terminal domain; Region: RuvA_N; pfam01330
591365005604	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
591365005605	non-specific DNA binding site [nucleotide binding]; other site
591365005606	salt bridge; other site
591365005607	sequence-specific DNA binding site [nucleotide binding]; other site
591365005608	RDD family; Region: RDD; cl00746
591365005609	DNA mismatch repair protein; Reviewed; Region: mutL; PRK00095
591365005610	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
591365005611	ATP binding site [chemical binding]; other site
591365005612	Mg2+ binding site [ion binding]; other site
591365005613	G-X-G motif; other site
591365005614	MutL_Trans: transducer domain, having a ribosomal S5 domain 2-like fold, conserved in the C-terminal domain of DNA mismatch repair (MutL/MLH1/PMS2) family. This transducer domain is homologous to the second domain of the DNA gyrase B subunit, which is...; Region: MutL_Trans; cd00782
591365005615	ATP binding site [chemical binding]; other site
591365005616	MutL C terminal dimerisation domain; Region: MutL_C; pfam08676
591365005617	Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582
591365005618	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
591365005619	phiLC3 phage and phage-related integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes various bacterial (mainly gram positive) and phage integrases, including those similar to Lactococcus...; Region: INT_phiLC3_C; cd01189
591365005620	Int/Topo IB signature motif; other site
591365005621	Abi-like protein; Region: Abi_2; pfam07751
591365005622	Fic family protein [Function unknown]; Region: COG3177
591365005623	Fic/DOC family; Region: Fic; pfam02661
591365005624	MTH538 TIR-like domain (DUF1863); Region: DUF1863; pfam08937
591365005625	Protein of unknown function (DUF4231); Region: DUF4231; pfam14015
591365005626	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
591365005627	non-specific DNA binding site [nucleotide binding]; other site
591365005628	salt bridge; other site
591365005629	sequence-specific DNA binding site [nucleotide binding]; other site
591365005630	Phage regulatory protein Rha (Phage_pRha); Region: Phage_pRha; cl10713
591365005631	Uncharacterized phage-encoded protein [Function unknown]; Region: COG3646
591365005632	Phage head-tail joining protein; Region: Phage_H_T_join; pfam05521
591365005633	N-terminal phage replisome organiser (Phage_rep_org_N); Region: Phage_rep_org_N; pfam09681
591365005634	DnaD and phage-associated domain; Region: DnaD_dom; TIGR01446
591365005635	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189
591365005636	Walker A motif; other site
591365005637	ATP binding site [chemical binding]; other site
591365005638	Walker B motif; other site
591365005639	arginine finger; other site
591365005640	Protein of unknown function (DUF1492); Region: DUF1492; pfam07374
591365005641	Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279
591365005642	LytTr DNA-binding domain; Region: LytTR; smart00850
591365005643	Protein of unknown function (DUF3021); Region: DUF3021; pfam11457
591365005644	DNA mismatch repair protein MutS; Provisional; Region: PRK05399
591365005645	MutS domain I; Region: MutS_I; pfam01624
591365005646	MutS domain II; Region: MutS_II; pfam05188
591365005647	MutS domain III; Region: MutS_III; pfam05192
591365005648	ATP-binding cassette domain of MutS1 homolog; Region: ABC_MutS1; cd03284
591365005649	Walker A/P-loop; other site
591365005650	ATP binding site [chemical binding]; other site
591365005651	Q-loop/lid; other site
591365005652	ABC transporter signature motif; other site
591365005653	Walker B; other site
591365005654	D-loop; other site
591365005655	H-loop/switch region; other site
591365005656	Arginine repressor, DNA binding domain; Region: Arg_repressor; pfam01316
591365005657	arginine repressor; Region: argR_whole; TIGR01529
591365005658	Arginine repressor, C-terminal domain; Region: Arg_repressor_C; pfam02863
591365005659	arginyl-tRNA synthetase; Reviewed; Region: PRK12451
591365005660	Arginyl tRNA synthetase N terminal dom; Region: Arg_tRNA_synt_N; smart01016
591365005661	catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671
591365005662	active site
591365005663	HIGH motif; other site
591365005664	KMSK motif region; other site
591365005665	Anticodon-binding domain of arginyl tRNA synthetases; Region: Anticodon_Ia_Arg; cd07956
591365005666	tRNA binding surface [nucleotide binding]; other site
591365005667	anticodon binding site; other site
591365005668	NrdI Flavodoxin like; Region: Flavodoxin_NdrI; cl17293
591365005669	glycogen/starch/alpha-glucan phosphorylases; Region: P_ylase; TIGR02093
591365005670	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
591365005671	4-alpha-glucanotransferase; Provisional; Region: PRK14508
591365005672	Maltose-binding periplasmic proteins/domains [Carbohydrate transport and metabolism]; Region: MalE; COG2182
591365005673	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
591365005674	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
591365005675	dimer interface [polypeptide binding]; other site
591365005676	conserved gate region; other site
591365005677	putative PBP binding loops; other site
591365005678	ABC-ATPase subunit interface; other site
591365005679	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
591365005680	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
591365005681	dimer interface [polypeptide binding]; other site
591365005682	conserved gate region; other site
591365005683	putative PBP binding loops; other site
591365005684	ABC-ATPase subunit interface; other site
591365005685	Predicted integral membrane protein [Function unknown]; Region: COG5521
591365005686	Transcriptional regulators [Transcription]; Region: PurR; COG1609
591365005687	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
591365005688	DNA binding site [nucleotide binding]
591365005689	domain linker motif; other site
591365005690	Ligand-binding domain of uncharacterized transcription regulator ycjW which is a member of the LacI-GalR family repressors; Region: PBP1_ycjW_transcription_regulator_like; cd06294
591365005691	putative dimerization interface [polypeptide binding]; other site
591365005692	putative ligand binding site [chemical binding]; other site
591365005693	pullulanase, type I; Region: pulA_typeI; TIGR02104
591365005694	Early set domain associated with the catalytic domain of pullulanase (also called dextrinase and alpha-dextrin endo-1,6-alpha glucosidase); Region: E_set_Pullulanase; cd02860
591365005695	Alpha amylase catalytic domain found in Pullulanase (also called dextrinase; alpha-dextrin endo-1,6-alpha glucosidase), limit dextrinase, and related proteins; Region: AmyAc_Pullulanase_LD-like; cd11341
591365005696	Ca binding site [ion binding]; other site
591365005697	active site
591365005698	catalytic site [active]
591365005699	Uncharacterized conserved protein [Function unknown]; Region: COG1284
591365005700	Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588
591365005701	Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588
591365005702	Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035
591365005703	aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476
591365005704	EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317
591365005705	dimer interface [polypeptide binding]; other site
591365005706	anticodon binding site; other site
591365005707	Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777
591365005708	homodimer interface [polypeptide binding]; other site
591365005709	motif 1; other site
591365005710	active site
591365005711	motif 2; other site
591365005712	GAD domain; Region: GAD; pfam02938
591365005713	Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA.   PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268
591365005714	active site
591365005715	motif 3; other site
591365005716	histidyl-tRNA synthetase; Reviewed; Region: hisS; PRK00037
591365005717	Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773
591365005718	dimer interface [polypeptide binding]; other site
591365005719	motif 1; other site
591365005720	active site
591365005721	motif 2; other site
591365005722	motif 3; other site
591365005723	HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859
591365005724	anticodon binding site; other site
591365005725	50S ribosomal protein L32; Validated; Region: rpmF; PRK01110
591365005726	Predicted permease, cadmium resistance protein [Inorganic ion transport and metabolism]; Region: CadD; COG4300
591365005727	Cadmium resistance transporter; Region: Cad; pfam03596
591365005728	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
591365005729	putative DNA binding site [nucleotide binding]; other site
591365005730	putative Zn2+ binding site [ion binding]; other site
591365005731	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
591365005732	non-specific DNA binding site [nucleotide binding]; other site
591365005733	salt bridge; other site
591365005734	sequence-specific DNA binding site [nucleotide binding]; other site
591365005735	DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674
591365005736	FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580
591365005737	Plasmid replication protein; Region: Rep_2; pfam01719
591365005738	phiLC3 phage and phage-related integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes various bacterial (mainly gram positive) and phage integrases, including those similar to Lactococcus...; Region: INT_phiLC3_C; cd01189
591365005739	Int/Topo IB signature motif; other site
591365005740	Serine/threonine protein kinase [General function prediction only / Signal transduction mechanisms / Transcription / DNA replication, recombination, and repair]; Region: SPS1; COG0515
591365005741	Protein Kinases, catalytic domain; Region: PKc_like; cl09925
591365005742	active site
591365005743	ATP binding site [chemical binding]; other site
591365005744	substrate binding site [chemical binding]; other site
591365005745	activation loop (A-loop); other site
591365005746	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
591365005747	non-specific DNA binding site [nucleotide binding]; other site
591365005748	salt bridge; other site
591365005749	sequence-specific DNA binding site [nucleotide binding]; other site
591365005750	transcriptional activator, Rgg/GadR/MutR family, C-terminal domain; Region: RGG_Cterm; TIGR01716
591365005751	heavy metal translocating P-type ATPase; Region: ATPase-IB_hvy; TIGR01525
591365005752	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
591365005753	haloacid dehalogenase-like hydrolase; Region: HAD; cl17202
591365005754	Cyanate permease [Inorganic ion transport and metabolism]; Region: CynX; COG2807
591365005755	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
591365005756	putative substrate translocation pore; other site
591365005757	Alkyladenine DNA glycosylase catalyzes the first step in base excision repair; Region: AAG; cd00540
591365005758	active site
591365005759	DNA binding site [nucleotide binding]
591365005760	Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349
591365005761	helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420
591365005762	DeoR C terminal sensor domain; Region: DeoRC; pfam00455
591365005763	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
591365005764	haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282
591365005765	active site
591365005766	motif I; other site
591365005767	motif II; other site
591365005768	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
591365005769	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
591365005770	Protein involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein) [Cell envelope biogenesis, outer membrane]; Region: DltD; COG3966
591365005771	DltD N-terminal region; Region: DltD_N; pfam04915
591365005772	DltD central region; Region: DltD_M; pfam04918
591365005773	DltD C-terminal region; Region: DltD_C; pfam04914
591365005774	D-alanyl-lipoteichoic acid biosynthesis protein DltB; Region: LTA_dltB; TIGR04091
591365005775	D-alanine--poly(phosphoribitol) ligase subunit 1; Provisional; Region: PRK04813
591365005776	D-alanine:D-alanyl carrier protein ligase (DltA); Region: DltA; cd05945
591365005777	acyl-activating enzyme (AAE) consensus motif; other site
591365005778	AMP binding site [chemical binding]; other site
591365005779	Predicted transcriptional regulators [Transcription]; Region: COG1695
591365005780	Transcriptional regulator PadR-like family; Region: PadR; cl17335
591365005781	Predicted membrane protein [Function unknown]; Region: COG4709
591365005782	Domain of unknown function (DUF4097); Region: DUF4097; pfam13349
591365005783	Domain of unknown function (DUF4098); Region: DUF4098; pfam13345
591365005784	Predicted hydrolase (HAD superfamily) [General function prediction only]; Region: COG1011
591365005785	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
591365005786	motif II; other site
591365005787	Domain of unknown function (DUF4353); Region: DUF4353; pfam14262
591365005788	Polyphosphate(polyP) polymerase domain of yeast vacuolar transport chaperone (VTC) proteins VTC-2, -3 and- 4, and similar proteins; Region: PolyPPase_VTC_like; cd07750
591365005789	putative metal binding residues [ion binding]; other site
591365005790	signature motif; other site
591365005791	dimer interface [polypeptide binding]; other site
591365005792	active site
591365005793	polyP binding site; other site
591365005794	substrate binding site [chemical binding]; other site
591365005795	acceptor-phosphate pocket; other site
591365005796	conjugal transfer protein TrbB; Provisional; Region: PRK13728; cl17283
591365005797	haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282
591365005798	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
591365005799	active site
591365005800	motif I; other site
591365005801	motif II; other site
591365005802	haloacid dehalogenase-like hydrolase; Region: HAD; cl17202
591365005803	Predicted membrane protein [Function unknown]; Region: COG1511
591365005804	YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061
591365005805	YhgE/Pip C-terminal domain; Region: pip_yhgE_Cterm; TIGR03062
591365005806	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
591365005807	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
591365005808	30S ribosomal protein S4; Validated; Region: rpsD; PRK05327
591365005809	Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163
591365005810	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
591365005811	RNA binding surface [nucleotide binding]; other site
591365005812	Haloacid dehalogenase-like hydrolase; Region: HAD_2; pfam13419
591365005813	?-D-glucose-1-phosphatase; Provisional; Region: PRK09456
591365005814	replicative DNA helicase; Provisional; Region: PRK05748
591365005815	DnaB-like helicase N terminal domain; Region: DnaB; pfam00772
591365005816	DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the  chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984
591365005817	Walker A motif; other site
591365005818	ATP binding site [chemical binding]; other site
591365005819	Walker B motif; other site
591365005820	DNA binding loops [nucleotide binding]
591365005821	50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137
591365005822	Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281
591365005823	Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948
591365005824	Predicted signaling protein consisting of a modified GGDEF domain and a DHH domain [Signal transduction mechanisms]; Region: COG3887
591365005825	DHH family; Region: DHH; pfam01368
591365005826	DHHA1 domain; Region: DHHA1; pfam02272
591365005827	tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA; Validated; Region: PRK05192
591365005828	tRNA:m(5)U-54 methyltransferase; Region: gid_trmFO; TIGR00137
591365005829	GidA associated domain 3; Region: GIDA_assoc_3; pfam13932
591365005830	Predicted tRNA(5-methylaminomethyl-2-thiouridylate) methyltransferase, contains the PP-loop ATPase domain [Translation, ribosomal structure and biogenesis]; Region: TrmU; COG0482
591365005831	tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998
591365005832	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
591365005833	FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388
591365005834	L-serine dehydratase, iron-sulfur-dependent, beta subunit; Region: sda_beta; TIGR00719
591365005835	Serine dehydratase beta chain; Region: SDH_beta; pfam03315
591365005836	C-terminal ACT domain of the L-serine dehydratase (LSD), iron-sulfur-dependent, beta subunit; Region: ACT_LSD; cd04903
591365005837	putative L-serine binding site [chemical binding]; other site
591365005838	Serine dehydratase alpha chain; Region: SDH_alpha; cl12120
591365005839	L-serine deaminase [Amino acid transport and metabolism]; Region: SdaA; COG1760
591365005840	Predicted phosphatases [General function prediction only]; Region: Gph; COG0546
591365005841	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
591365005842	motif II; other site
591365005843	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
591365005844	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
591365005845	N-acetyl-D-glucosamine binding site [chemical binding]; other site
591365005846	catalytic residue [active]
591365005847	ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619
591365005848	cobalt transporter ATP-binding subunit; Provisional; Region: cbiO; PRK13649
591365005849	First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225
591365005850	Walker A/P-loop; other site
591365005851	ATP binding site [chemical binding]; other site
591365005852	Q-loop/lid; other site
591365005853	ABC transporter signature motif; other site
591365005854	Walker B; other site
591365005855	D-loop; other site
591365005856	H-loop/switch region; other site
591365005857	cobalt transporter ATP-binding subunit; Provisional; Region: cbiO; PRK13650
591365005858	First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225
591365005859	Walker A/P-loop; other site
591365005860	ATP binding site [chemical binding]; other site
591365005861	Q-loop/lid; other site
591365005862	ABC transporter signature motif; other site
591365005863	Walker B; other site
591365005864	D-loop; other site
591365005865	H-loop/switch region; other site
591365005866	CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453
591365005867	Predicted transcriptional regulator contains Xre-like HTH domain [Function unknown]; Region: COG1426
591365005868	Helix-turn-helix domain; Region: HTH_25; pfam13413
591365005869	Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612
591365005870	Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675
591365005871	Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193
591365005872	Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612
591365005873	Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193
591365005874	S4 domain; Region: S4_2; cl17325
591365005875	recombination protein F; Reviewed; Region: recF; PRK00064
591365005876	ATP-binding cassette domain of RecF; Region: ABC_RecF; cd03242
591365005877	Walker A/P-loop; other site
591365005878	ATP binding site [chemical binding]; other site
591365005879	Q-loop/lid; other site
591365005880	ABC transporter signature motif; other site
591365005881	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
591365005882	ABC transporter signature motif; other site
591365005883	Walker B; other site
591365005884	D-loop; other site
591365005885	H-loop/switch region; other site
591365005886	inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567
591365005887	TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186
591365005888	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein.  IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a...; Region: CBS_pair_IMPDH; cd04601
591365005889	IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381
591365005890	active site
591365005891	tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282
591365005892	catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806
591365005893	active site
591365005894	HIGH motif; other site
591365005895	dimer interface [polypeptide binding]; other site
591365005896	KMSKS motif; other site
591365005897	UDP-glucose 4-epimerase [Cell envelope biogenesis, outer membrane]; Region: GalE; COG1087
591365005898	UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247
591365005899	NAD binding site [chemical binding]; other site
591365005900	homodimer interface [polypeptide binding]; other site
591365005901	active site
591365005902	substrate binding site [chemical binding]; other site
591365005903	Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311
591365005904	substrate binding site [chemical binding]; other site
591365005905	dimer interface [polypeptide binding]; other site
591365005906	catalytic triad [active]
591365005907	Flavodoxin-like fold; Region: Flavodoxin_2; pfam02525
591365005908	ABC transporter ATP-binding protein; Provisional; Region: PRK15064
591365005909	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
591365005910	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
591365005911	ABC transporter; Region: ABC_tran_2; pfam12848
591365005912	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
591365005913	Predicted membrane protein [Function unknown]; Region: COG4485
591365005914	Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279
591365005915	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
591365005916	active site
591365005917	phosphorylation site [posttranslational modification]
591365005918	intermolecular recognition site; other site
591365005919	dimerization interface [polypeptide binding]; other site
591365005920	LytTr DNA-binding domain; Region: LytTR; pfam04397
591365005921	Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518
591365005922	ATP binding site [chemical binding]; other site
591365005923	Mg2+ binding site [ion binding]; other site
591365005924	G-X-G motif; other site
591365005925	rRNA large subunit methyltransferase; Provisional; Region: PRK00103
591365005926	Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365
591365005927	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
591365005928	protein binding site [polypeptide binding]; other site
591365005929	ParB/RepB/Spo0J family partition protein; Region: parB_part; TIGR00180
591365005930	ParB-like nuclease domain; Region: ParBc; pfam02195
591365005931	KorB domain; Region: KorB; pfam08535