-- dump date   	20140620_082951
-- class       	Genbank::misc_feature
-- table       	misc_feature_note
-- id	note
365659000001	chromosomal replication initiation protein; Reviewed; Region: dnaA; PRK00149
365659000002	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
365659000003	Walker A motif; other site
365659000004	ATP binding site [chemical binding]; other site
365659000005	Walker B motif; other site
365659000006	arginine finger; other site
365659000007	C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571
365659000008	DnaA box-binding interface [nucleotide binding]; other site
365659000009	DNA polymerase III subunit beta; Validated; Region: PRK05643
365659000010	Beta clamp domain.  The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria.  The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140
365659000011	putative DNA binding surface [nucleotide binding]; other site
365659000012	dimer interface [polypeptide binding]; other site
365659000013	beta-clamp/clamp loader binding surface; other site
365659000014	beta-clamp/translesion DNA polymerase binding surface; other site
365659000015	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4481
365659000016	GTP-binding protein YchF; Reviewed; Region: PRK09601
365659000017	YchF GTPase; Region: YchF; cd01900
365659000018	G1 box; other site
365659000019	GTP/Mg2+ binding site [chemical binding]; other site
365659000020	Switch I region; other site
365659000021	G2 box; other site
365659000022	Switch II region; other site
365659000023	G3 box; other site
365659000024	G4 box; other site
365659000025	G5 box; other site
365659000026	TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867
365659000027	Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462
365659000028	putative active site [active]
365659000029	catalytic residue [active]
365659000030	Transcription-repair coupling factor (superfamily II helicase) [DNA replication, recombination, and repair / Transcription]; Region: Mfd; COG1197
365659000031	CarD-like/TRCF domain; Region: CarD_TRCF; smart01058
365659000032	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
365659000033	ATP binding site [chemical binding]; other site
365659000034	putative Mg++ binding site [ion binding]; other site
365659000035	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
365659000036	nucleotide binding region [chemical binding]; other site
365659000037	ATP-binding site [chemical binding]; other site
365659000038	This domain is found in proteins necessary for strand-specific repair in DNA such as TRCF in Escherichia coli; Region: TRCF; smart00982
365659000039	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
365659000040	RNA binding surface [nucleotide binding]; other site
365659000041	Septum formation initiator [Cell division and chromosome partitioning]; Region: COG2919
365659000042	Beta-lactamase class A [Defense mechanisms]; Region: PenP; COG2367
365659000043	Beta-lactamase enzyme family; Region: Beta-lactamase2; pfam13354
365659000044	tRNA(Ile)-lysidine synthase MesJ [Cell cycle control, cell division, chromosome partitioning]; Region: MesJ; COG0037
365659000045	N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992
365659000046	Ligand Binding Site [chemical binding]; other site
365659000047	TilS substrate C-terminal domain; Region: TilS_C; smart00977
365659000048	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
365659000049	active site
365659000050	ATP-dependent Zn proteases [Posttranslational modification, protein turnover, chaperones]; Region: HflB; COG0465
365659000051	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
365659000052	Walker A motif; other site
365659000053	ATP binding site [chemical binding]; other site
365659000054	Walker B motif; other site
365659000055	arginine finger; other site
365659000056	Peptidase family M41; Region: Peptidase_M41; pfam01434
365659000057	RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937
365659000058	Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826
365659000059	Helix-turn-helix domain; Region: HTH_38; pfam13936
365659000060	Integrase core domain; Region: rve; pfam00665
365659000061	Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788
365659000062	Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108
365659000063	GDP-binding site [chemical binding]; other site
365659000064	ACT binding site; other site
365659000065	IMP binding site; other site
365659000066	Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285
365659000067	nucleoside/Zn binding site; other site
365659000068	dimer interface [polypeptide binding]; other site
365659000069	catalytic motif [active]
365659000070	Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557
365659000071	trimer interface [polypeptide binding]; other site
365659000072	active site
365659000073	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
365659000074	catalytic core [active]
365659000075	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
365659000076	Walker A motif; other site
365659000077	ATP binding site [chemical binding]; other site
365659000078	ATPases associated with a variety of cellular activities; Region: AAA; smart00382
365659000079	Walker B motif; other site
365659000080	Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541
365659000081	Uncharacterized conserved protein [Function unknown]; Region: COG2013
365659000082	Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeD; cd03379
365659000083	active site clefts [active]
365659000084	zinc binding site [ion binding]; other site
365659000085	dimer interface [polypeptide binding]; other site
365659000086	Membrane proteinase, regulator of anti-sigma factor [Posttranslational modification, protein turnover, chaperones]; Region: prsW; COG2339
365659000087	Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826
365659000088	Helix-turn-helix domain; Region: HTH_38; pfam13936
365659000089	Integrase core domain; Region: rve; pfam00665
365659000090	ribose-phosphate pyrophosphokinase; Provisional; Region: PRK02269
365659000091	N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793
365659000092	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
365659000093	active site
365659000094	PD-(D/E)XK nuclease family transposase; Region: PDDEXK_2; pfam12784
365659000095	authentic stop codon
365659000096	glucan-binding repeat; Region: glucan_65_rpt; TIGR04035
365659000097	Putative cell wall binding repeat; Region: CW_binding_1; pfam01473
365659000098	Putative cell wall binding repeat; Region: CW_binding_1; pfam01473
365659000099	Putative cell wall binding repeat; Region: CW_binding_1; pfam01473
365659000100	FOG: Glucan-binding domain (YG repeat) [General function prediction only]; Region: COG5263
365659000101	Putative cell wall binding repeat; Region: CW_binding_1; pfam01473
365659000102	Putative cell wall binding repeat; Region: CW_binding_1; pfam01473
365659000103	Putative cell wall binding repeat; Region: CW_binding_1; pfam01473
365659000104	glucan-binding repeat; Region: glucan_65_rpt; TIGR04035
365659000105	Putative cell wall binding repeat; Region: CW_binding_1; pfam01473
365659000106	Putative cell wall binding repeat; Region: CW_binding_1; pfam01473
365659000107	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436
365659000108	IS66 Orf2 like protein; Region: TnpB_IS66; pfam05717
365659000109	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436
365659000110	putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; pfam13005
365659000111	Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050
365659000112	Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050
365659000113	Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826
365659000114	Helix-turn-helix domain; Region: HTH_38; pfam13936
365659000115	Integrase core domain; Region: rve; pfam00665
365659000116	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
365659000117	AAA domain; Region: AAA_21; pfam13304
365659000118	Walker A/P-loop; other site
365659000119	ATP binding site [chemical binding]; other site
365659000121	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
365659000122	dimerization interface [polypeptide binding]; other site
365659000123	putative DNA binding site [nucleotide binding]; other site
365659000124	Winged helix-turn helix; Region: HTH_29; pfam13551
365659000125	putative Zn2+ binding site [ion binding]; other site
365659000126	DDE superfamily endonuclease; Region: DDE_3; pfam13358
365659000127	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335
365659000128	PD-(D/E)XK nuclease family transposase; Region: PDDEXK_2; pfam12784
365659000129	DNA polymerase I; Provisional; Region: PRK05755
365659000130	PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859
365659000131	active site
365659000132	metal binding site 1 [ion binding]; metal-binding site
365659000133	putative 5' ssDNA interaction site; other site
365659000134	metal binding site 3; metal-binding site
365659000135	metal binding site 2 [ion binding]; metal-binding site
365659000136	H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898
365659000137	putative DNA binding site [nucleotide binding]; other site
365659000138	putative metal binding site [ion binding]; other site
365659000139	inactive DEDDy 3'-5' exonuclease domain of Bacillus stearothermophilus DNA polymerase I and similar family-A DNA polymerases; Region: DNA_polA_I_Bacillus_like_exo; cd06140
365659000140	Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637
365659000141	active site
365659000142	DNA binding site [nucleotide binding]
365659000143	catalytic site [active]
365659000144	Predicted CoA-binding protein [General function prediction only]; Region: COG1832
365659000145	Predicted membrane protein [Function unknown]; Region: COG2855
365659000146	aromatic amino acid aminotransferase; Validated; Region: PRK07309
365659000147	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
365659000148	pyridoxal 5'-phosphate binding site [chemical binding]; other site
365659000149	homodimer interface [polypeptide binding]; other site
365659000150	catalytic residue [active]
365659000151	Recombinational DNA repair protein (RecF pathway) [DNA replication, recombination, and repair]; Region: RecO; COG1381
365659000152	Recombination protein O N terminal; Region: RecO_N; pfam11967
365659000153	Recombination protein O C terminal; Region: RecO_C; pfam02565
365659000154	putative phosphate acyltransferase; Provisional; Region: PRK05331
365659000155	FOG: Glucan-binding domain (YG repeat) [General function prediction only]; Region: COG5263
365659000156	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
365659000157	non-specific DNA binding site [nucleotide binding]; other site
365659000158	salt bridge; other site
365659000159	sequence-specific DNA binding site [nucleotide binding]; other site
365659000160	FOG: Glucan-binding domain (YG repeat) [General function prediction only]; Region: COG5263
365659000161	COMC family; Region: ComC; pfam03047
365659000162	Predicted signal transduction protein with a C-terminal ATPase domain [Signal transduction mechanisms]; Region: COG2972
365659000163	Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518
365659000164	ATP binding site [chemical binding]; other site
365659000165	Mg2+ binding site [ion binding]; other site
365659000166	G-X-G motif; other site
365659000167	Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279
365659000168	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
365659000169	active site
365659000170	phosphorylation site [posttranslational modification]
365659000171	intermolecular recognition site; other site
365659000172	dimerization interface [polypeptide binding]; other site
365659000173	LytTr DNA-binding domain; Region: LytTR; pfam04397
365659000174	A sub-family of peptidase family C39. Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various...; Region: Peptidase_C39B; cd02418
365659000175	ABC-type bacteriocin transporter; Region: bacteriocin_ABC; TIGR01193
365659000176	putative active site [active]
365659000177	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
365659000178	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
365659000179	Walker A/P-loop; other site
365659000180	ATP binding site [chemical binding]; other site
365659000181	Q-loop/lid; other site
365659000182	ABC transporter signature motif; other site
365659000183	Walker B; other site
365659000184	D-loop; other site
365659000185	H-loop/switch region; other site
365659000186	bacteriocin secretion accessory protein; Region: bacteriocin_acc; TIGR01000
365659000187	HlyD family secretion protein; Region: HlyD_3; pfam13437
365659000188	phosphoribosylaminoimidazole-succinocarboxamide synthase; Reviewed; Region: PRK09362
365659000189	bacterial and archaeal 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_PurC; cd01415
365659000190	ATP binding site [chemical binding]; other site
365659000191	active site
365659000192	substrate binding site [chemical binding]; other site
365659000193	phosphoribosylformylglycinamidine synthase, clade II; Region: FGAM-synthase; TIGR01857
365659000194	AIR (aminoimidazole ribonucleotide) synthase related protein. This family includes Hydrogen expression/formation protein HypE, AIR synthases, FGAM (formylglycinamidine ribonucleotide) synthase and Selenophosphate synthetase (SelD). The N-terminal domain...; Region: PurM-like; cl10019
365659000195	PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203
365659000196	dimerization interface [polypeptide binding]; other site
365659000197	ATP binding site [chemical binding]; other site
365659000198	PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat2; cd02204
365659000199	dimerization interface [polypeptide binding]; other site
365659000200	ATP binding site [chemical binding]; other site
365659000201	Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740
365659000202	putative active site [active]
365659000203	catalytic triad [active]
365659000204	amidophosphoribosyltransferase; Provisional; Region: PRK07272
365659000205	Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of  glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715
365659000206	active site
365659000207	tetramer interface [polypeptide binding]; other site
365659000208	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
365659000209	active site
365659000210	phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385
365659000211	PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196
365659000212	dimerization interface [polypeptide binding]; other site
365659000213	putative ATP binding site [chemical binding]; other site
365659000214	phosphoribosylglycinamide formyltransferase; Reviewed; Region: purN; PRK05647
365659000215	Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645
365659000216	active site
365659000217	substrate binding site [chemical binding]; other site
365659000218	cosubstrate binding site; other site
365659000219	catalytic site [active]
365659000220	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
365659000221	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
365659000222	Coenzyme A binding pocket [chemical binding]; other site
365659000223	bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881
365659000224	Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal  ATIC formylase domain that formylates...; Region: IMPCH; cd01421
365659000225	purine monophosphate binding site [chemical binding]; other site
365659000226	dimer interface [polypeptide binding]; other site
365659000227	putative catalytic residues [active]
365659000228	AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; smart00798
365659000229	AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; cl03362
365659000230	phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885
365659000231	Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844
365659000232	Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Region: GARS_A; pfam01071
365659000233	Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843
365659000234	Phosphoribosylcarboxyaminoimidazole (NCAIR) mutase [Nucleotide transport and metabolism]; Region: PurE; COG0041
365659000235	phosphoribosylaminoimidazole carboxylase ATPase subunit; Reviewed; Region: PRK06019
365659000236	ATP-grasp domain; Region: ATP-grasp; pfam02222
365659000237	adenylosuccinate lyase; Provisional; Region: PRK07492
365659000238	Adenylsuccinate lyase (ASL)_subgroup 1; Region: Adenylsuccinate_lyase_1; cd01360
365659000239	tetramer interface [polypeptide binding]; other site
365659000240	active site
365659000241	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464
365659000242	Transposase; Region: DDE_Tnp_ISL3; pfam01610
365659000243	Transcriptional regulators [Transcription]; Region: PhnF; COG2188
365659000244	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
365659000245	DNA-binding site [nucleotide binding]; DNA binding site
365659000246	The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; Region: UTRA; smart00866
365659000247	Beta-galactosidase [Carbohydrate transport and metabolism]; Region: LacA; COG1874
365659000248	Glycosyl hydrolases family 35; Region: Glyco_hydro_35; pfam01301
365659000249	PTS_IIB, PTS system, Mannose/sorbose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_man; cd00001
365659000250	active site
365659000251	phosphorylation site [posttranslational modification]
365659000252	Phosphotransferase system, mannose/fructose/N-acetylgalactosamine-specific component IIC [Carbohydrate transport and metabolism]; Region: ManY; COG3715
365659000253	Phosphotransferase system, mannose/fructose/N-acetylgalactosamine-specific component IID [Carbohydrate transport and metabolism]; Region: ManZ; COG3716
365659000254	PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006
365659000255	active pocket/dimerization site; other site
365659000256	active site
365659000257	phosphorylation site [posttranslational modification]
365659000258	putative sugar isomerase, AgaS family; Region: agaS_fam; TIGR02815
365659000259	SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008
365659000260	dimer interface [polypeptide binding]; other site
365659000261	active site
365659000262	AgaS-like protein. AgaS contains a SIS (Sugar ISomerase) domain which is found in many phosphosugar isomerases and phosphosugar binding proteins. AgaS is a putative isomerase in Escherichia coli. It is similar to the glucosamine-6-phosphate synthases; Region: SIS_AgaS_like; cd05010
365659000263	putative active site [active]
365659000264	authentic stop codon
365659000265	SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379
365659000266	FOG: Glucan-binding domain (YG repeat) [General function prediction only]; Region: COG5263
365659000267	Putative cell wall binding repeat; Region: CW_binding_1; pfam01473
365659000268	Putative cell wall binding repeat; Region: CW_binding_1; pfam01473
365659000269	Putative cell wall binding repeat; Region: CW_binding_1; pfam01473
365659000270	Phosphorylase superfamily; Region: PNP_UDP_1; pfam01048
365659000271	Trk-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: TrkG; COG0168
365659000272	potassium uptake protein, TrkH family; Region: 2a38; TIGR00933
365659000273	K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569
365659000274	TrkA-N domain; Region: TrkA_N; pfam02254
365659000275	TrkA-C domain; Region: TrkA_C; pfam02080
365659000276	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
365659000277	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761
365659000278	active site
365659000279	Fibronectin-binding repeat; Region: SSURE; pfam11966
365659000280	Fibronectin-binding repeat; Region: SSURE; pfam11966
365659000281	Fibronectin-binding repeat; Region: SSURE; pfam11966
365659000282	Fibronectin-binding repeat; Region: SSURE; pfam11966
365659000283	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
365659000284	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
365659000285	active site
365659000286	phosphorylation site [posttranslational modification]
365659000287	intermolecular recognition site; other site
365659000288	dimerization interface [polypeptide binding]; other site
365659000289	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
365659000290	DNA binding site [nucleotide binding]
365659000291	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
365659000292	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
365659000293	dimerization interface [polypeptide binding]; other site
365659000294	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
365659000295	dimer interface [polypeptide binding]; other site
365659000296	phosphorylation site [posttranslational modification]
365659000297	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
365659000298	ATP binding site [chemical binding]; other site
365659000299	Mg2+ binding site [ion binding]; other site
365659000300	G-X-G motif; other site
365659000301	30S ribosomal protein S4; Validated; Region: rpsD; PRK05327
365659000302	Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163
365659000303	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
365659000304	RNA binding surface [nucleotide binding]; other site
365659000305	Cysteine-rich CPCC; Region: Cys_rich_CPCC; pfam14206
365659000306	Cysteine-rich CPCC; Region: Cys_rich_CPCC; pfam14206
365659000307	RelB antitoxin; Region: RelB; cl01171
365659000308	Plasmid stabilisation system protein; Region: Plasmid_stabil; pfam05016
365659000309	chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168
365659000310	Uncharacterized protein involved in tellurite resistance [Inorganic ion transport and metabolism]; Region: TelA; COG3853
365659000311	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
365659000312	putative DNA binding site [nucleotide binding]; other site
365659000313	putative Zn2+ binding site [ion binding]; other site
365659000314	Predicted permease, cadmium resistance protein [Inorganic ion transport and metabolism]; Region: CadD; COG4300
365659000315	Cadmium resistance transporter; Region: Cad; pfam03596
365659000316	50S ribosomal protein L33; Validated; Region: rpmG; PRK00595
365659000317	50S ribosomal protein L32; Validated; Region: rpmF; PRK01110
365659000318	Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826
365659000319	Helix-turn-helix domain; Region: HTH_38; pfam13936
365659000320	Integrase core domain; Region: rve; pfam00665
365659000321	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4877
365659000322	Transcriptional antiterminator [Transcription]; Region: BglG; COG3711
365659000323	PRD domain; Region: PRD; pfam00874
365659000324	PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568
365659000325	active site
365659000326	P-loop; other site
365659000327	phosphorylation site [posttranslational modification]
365659000328	PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211
365659000329	active site
365659000330	phosphorylation site [posttranslational modification]
365659000331	PTS_IIB_ascorbate: subunit IIB of enzyme II (EII) of the L-ascorbate-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is an L-ascorbate-specific permease with two cytoplasmic subunits (IIA and IIB) and a...; Region: PTS_IIB_ascorbate; cd05563
365659000332	active site
365659000333	P-loop; other site
365659000334	phosphorylation site [posttranslational modification]
365659000335	PTS system ascorbate-specific transporter subunit IIC; Reviewed; Region: ulaA; PRK09410
365659000336	Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012
365659000337	TPP-binding site [chemical binding]; other site
365659000338	dimer interface [polypeptide binding]; other site
365659000339	Transketolase, C-terminal subunit [Carbohydrate transport and metabolism]; Region: COG3958
365659000340	Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033
365659000341	PYR/PP interface [polypeptide binding]; other site
365659000342	dimer interface [polypeptide binding]; other site
365659000343	TPP binding site [chemical binding]; other site
365659000344	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
365659000345	6-phosphogluconate dehydratase; Region: edd; TIGR01196
365659000346	dihydroxy-acid dehydratase; Provisional; Region: PRK00911
365659000347	Predicted metal-sulfur cluster biosynthetic enzyme [General function prediction only]; Region: PaaD; COG2151
365659000348	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
365659000349	non-specific DNA binding site [nucleotide binding]; other site
365659000350	salt bridge; other site
365659000351	sequence-specific DNA binding site [nucleotide binding]; other site
365659000352	transcriptional activator, Rgg/GadR/MutR family, C-terminal domain; Region: RGG_Cterm; TIGR01716
365659000353	histidyl-tRNA synthetase; Reviewed; Region: hisS; PRK00037
365659000354	Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773
365659000355	dimer interface [polypeptide binding]; other site
365659000356	motif 1; other site
365659000357	active site
365659000358	motif 2; other site
365659000359	motif 3; other site
365659000360	HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859
365659000361	anticodon binding site; other site
365659000362	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
365659000363	non-specific DNA binding site [nucleotide binding]; other site
365659000364	salt bridge; other site
365659000365	sequence-specific DNA binding site [nucleotide binding]; other site
365659000366	Protein of unknown function (DUF3169); Region: DUF3169; pfam11368
365659000367	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
365659000368	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
365659000369	Walker A/P-loop; other site
365659000370	ATP binding site [chemical binding]; other site
365659000371	Q-loop/lid; other site
365659000372	ABC transporter signature motif; other site
365659000373	Walker B; other site
365659000374	D-loop; other site
365659000375	H-loop/switch region; other site
365659000376	CAAX protease self-immunity; Region: Abi; pfam02517
365659000377	aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476
365659000378	EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317
365659000379	dimer interface [polypeptide binding]; other site
365659000380	anticodon binding site; other site
365659000381	Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777
365659000382	homodimer interface [polypeptide binding]; other site
365659000383	motif 1; other site
365659000384	active site
365659000385	motif 2; other site
365659000386	GAD domain; Region: GAD; pfam02938
365659000387	Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777
365659000388	motif 3; other site
365659000389	Uncharacterized conserved protein [Function unknown]; Region: COG1284
365659000390	Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588
365659000391	Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588
365659000392	Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035
365659000393	Transcriptional regulators [Transcription]; Region: PurR; COG1609
365659000394	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
365659000395	DNA binding site [nucleotide binding]
365659000396	domain linker motif; other site
365659000397	Ligand-binding domain of uncharacterized transcription regulator ycjW which is a member of the LacI-GalR family repressors; Region: PBP1_ycjW_transcription_regulator_like; cd06294
365659000398	putative dimerization interface [polypeptide binding]; other site
365659000399	putative ligand binding site [chemical binding]; other site
365659000400	Predicted integral membrane protein [Function unknown]; Region: COG5521
365659000401	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
365659000402	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
365659000403	dimer interface [polypeptide binding]; other site
365659000404	conserved gate region; other site
365659000405	putative PBP binding loops; other site
365659000406	ABC-ATPase subunit interface; other site
365659000407	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
365659000408	dimer interface [polypeptide binding]; other site
365659000409	conserved gate region; other site
365659000410	putative PBP binding loops; other site
365659000411	ABC-ATPase subunit interface; other site
365659000412	Maltose-binding periplasmic proteins/domains [Carbohydrate transport and metabolism]; Region: MalE; COG2182
365659000413	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
365659000414	4-alpha-glucanotransferase; Provisional; Region: PRK14508
365659000415	glycogen/starch/alpha-glucan phosphorylases; Region: P_ylase; TIGR02093
365659000416	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
365659000417	23S rRNA methyltransferase A; Provisional; Region: rrmA; PRK11088
365659000418	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
365659000419	S-adenosylmethionine binding site [chemical binding]; other site
365659000420	heavy metal translocating P-type ATPase; Region: ATPase-IB_hvy; TIGR01525
365659000421	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
365659000422	Soluble P-type ATPase [General function prediction only]; Region: COG4087
365659000423	tyrosyl-tRNA synthetase; Validated; Region: PRK05912
365659000424	catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805
365659000425	active site
365659000426	HIGH motif; other site
365659000427	dimer interface [polypeptide binding]; other site
365659000428	KMSKS motif; other site
365659000429	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
365659000430	RNA binding surface [nucleotide binding]; other site
365659000431	Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826
365659000432	Helix-turn-helix domain; Region: HTH_38; pfam13936
365659000433	Integrase core domain; Region: rve; pfam00665
365659000434	authentic stop codon
365659000435	EamA-like transporter family; Region: EamA; pfam00892
365659000436	Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950
365659000437	Tetrahydrodipicolinate succinyltransferase N-terminal; Region: DapH_N; pfam08503
365659000438	2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-acetyltransferase; Region: DapD_Ac; TIGR03532
365659000439	2,3,4,5-tetrahydropyridine-2,6-dicarboxylate (THDP) N-succinyltransferase (also called THP succinyltransferase): THDP N-succinyltransferase catalyzes the conversion of tetrahydrodipicolinate and succinyl-CoA to N-succinyltetrahydrodipicolinate and CoA; Region: LbH_THP_succinylT; cd03350
365659000440	trimer interface [polypeptide binding]; other site
365659000441	active site
365659000442	substrate binding site [chemical binding]; other site
365659000443	CoA binding site [chemical binding]; other site
365659000444	Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473
365659000445	M20 Peptidase Aminoacyclase-1 YkuR-like proteins, including YkuR and Ama/HipO/HyuC proteins; Region: M20_Acy1_YkuR_like; cd05670
365659000446	metal binding site [ion binding]; metal-binding site
365659000447	putative dimer interface [polypeptide binding]; other site
365659000448	5-formyltetrahydrofolate cyclo-ligase family; Region: 5-FTHF_cyc-lig; pfam01812
365659000449	5,10-methenyltetrahydrofolate synthetase; Region: MTHFS_bact; TIGR02727
365659000450	Rhomboid family; Region: Rhomboid; pfam01694
365659000451	Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541
365659000452	dTDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: RfbA; COG1209
365659000453	active site
365659000454	tetramer interface; other site
365659000455	NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094
365659000456	NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210
365659000457	NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479
365659000458	arginyl-tRNA synthetase; Reviewed; Region: PRK12451
365659000459	Arginyl tRNA synthetase N terminal dom; Region: Arg_tRNA_synt_N; smart01016
365659000460	catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671
365659000461	active site
365659000462	HIGH motif; other site
365659000463	KMSK motif region; other site
365659000464	Anticodon-binding domain of arginyl tRNA synthetases; Region: Anticodon_Ia_Arg; cd07956
365659000465	tRNA binding surface [nucleotide binding]; other site
365659000466	anticodon binding site; other site
365659000467	Arginine repressor, DNA binding domain; Region: Arg_repressor; pfam01316
365659000468	arginine repressor; Region: argR_whole; TIGR01529
365659000469	Arginine repressor, C-terminal domain; Region: Arg_repressor_C; pfam02863
365659000470	DNA mismatch repair protein MutS; Region: mutS1; TIGR01070
365659000471	MutS domain I; Region: MutS_I; pfam01624
365659000472	MutS domain II; Region: MutS_II; pfam05188
365659000473	MutS domain III; Region: MutS_III; pfam05192
365659000474	MutS domain V; Region: MutS_V; pfam00488
365659000475	Walker A/P-loop; other site
365659000476	ATP binding site [chemical binding]; other site
365659000477	Q-loop/lid; other site
365659000478	ABC transporter signature motif; other site
365659000479	Walker B; other site
365659000480	D-loop; other site
365659000481	H-loop/switch region; other site
365659000482	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
365659000483	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
365659000484	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
365659000485	Walker A/P-loop; other site
365659000486	ATP binding site [chemical binding]; other site
365659000487	Q-loop/lid; other site
365659000488	ABC transporter signature motif; other site
365659000489	Walker B; other site
365659000490	D-loop; other site
365659000491	H-loop/switch region; other site
365659000492	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
365659000493	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
365659000494	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
365659000495	Walker A/P-loop; other site
365659000496	ATP binding site [chemical binding]; other site
365659000497	Q-loop/lid; other site
365659000498	ABC transporter signature motif; other site
365659000499	Walker B; other site
365659000500	D-loop; other site
365659000501	H-loop/switch region; other site
365659000502	Predicted glutamine amidotransferases [General function prediction only]; Region: COG2071
365659000503	Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_2; cd01745
365659000504	catalytic triad [active]
365659000505	Transposase IS200 like; Region: Y1_Tnp; pfam01797
365659000506	glucose-6-phosphate isomerase; Provisional; Region: pgi; PRK14097
365659000507	Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015
365659000508	active site
365659000509	dimer interface [polypeptide binding]; other site
365659000510	Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016
365659000511	dimer interface [polypeptide binding]; other site
365659000512	active site
365659000513	glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406
365659000514	catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808
365659000515	active site
365659000516	HIGH motif; other site
365659000517	catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808
365659000518	active site
365659000519	KMSKS motif; other site
365659000520	PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cl00025
365659000521	Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283
365659000522	active site
365659000523	catalytic motif [active]
365659000524	Zn binding site [ion binding]; other site
365659000525	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
365659000526	phosphoprotein phosphatases of the metallophosphatase superfamily, metallophosphatase domain; Region: MPP_PPP_family; cd00144
365659000527	active site
365659000528	metal binding site [ion binding]; metal-binding site
365659000529	Ribbon-helix-helix protein, copG family; Region: RHH_1; pfam01402
365659000530	HD domain; Region: HD_4; pfam13328
365659000531	integrase; Provisional; Region: int; PHA02601
365659000532	phiLC3 phage and phage-related integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes various bacterial (mainly gram positive) and phage integrases, including those similar to Lactococcus...; Region: INT_phiLC3_C; cd01189
365659000533	Int/Topo IB signature motif; other site
365659000534	Domain of unknown function (DUF3173); Region: DUF3173; pfam11372
365659000535	putative replication initiation protein; Region: PHA00330
365659000536	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
365659000537	metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995
365659000538	active site
365659000539	metal binding site [ion binding]; metal-binding site
365659000540	FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580
365659000541	DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674
365659000542	Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490
365659000543	putative catalytic site [active]
365659000544	putative metal binding site [ion binding]; other site
365659000545	putative phosphate binding site [ion binding]; other site
365659000546	Glutamate-cysteine ligase family 2(GCS2); Region: GCS2; cl00954
365659000547	Threonine synthase catalyzes the final step of threonine biosynthesis. The conversion of O-phosphohomoserine into threonine and inorganic phosphate is pyridoxal 5'-phosphate dependent. The Thr-synth_1 CD includes members from higher plants; Region: Thr-synth_2; cd01560
365659000548	Threonine synthase [Amino acid transport and metabolism]; Region: ThrC; COG0498
365659000549	pyridoxal 5'-phosphate binding site [chemical binding]; other site
365659000550	catalytic residue [active]
365659000551	Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534
365659000552	Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Thermotoga marina NorM; Region: MATE_NorM_like; cd13137
365659000553	Predicted phosphatases [General function prediction only]; Region: Gph; COG0546
365659000554	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
365659000555	motif II; other site
365659000556	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
365659000557	Pyroglutamyl peptidase (PGP) type I, also known as pyrrolidone carboxyl peptidase (pcp) type I:  Enzymes responsible for cleaving pyroglutamate (pGlu) from the N-terminal end of specialized proteins. The N-terminal pGlu protects these proteins from...; Region: Peptidase_C15; cd00501
365659000558	putative substrate binding pocket [chemical binding]; other site
365659000559	AC domain interface; other site
365659000560	catalytic triad [active]
365659000561	AB domain interface; other site
365659000562	interchain disulfide; other site
365659000563	Protein of unknown function (DUF975); Region: DUF975; cl10504
365659000564	queuine tRNA-ribosyltransferase; Provisional; Region: tgt; PRK00112
365659000565	Queuine/archaeosine tRNA-ribosyltransferase [Translation, ribosomal structure and biogenesis]; Region: Tgt; COG0343
365659000566	Predicted acyltransferases [Lipid metabolism]; Region: COG1835
365659000567	yrhL-like subfamily of SGNH-hydrolases, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase_yrhL_like; cd01840
365659000568	catalytic triad [active]
365659000569	catalytic triad [active]
365659000570	oxyanion hole [active]
365659000571	Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826
365659000572	Helix-turn-helix domain; Region: HTH_38; pfam13936
365659000573	Integrase core domain; Region: rve; pfam00665
365659000574	N-acetylglucosamine-6-phosphate deacetylase [Carbohydrate transport and metabolism]; Region: NagA; COG1820
365659000575	N-acetylglucosamine-6-phosphate deacetylase, NagA, catalyzes the hydrolysis of the N-acetyl group of N-acetyl-glucosamine-6-phosphate (GlcNAc-6-P) to glucosamine 6-phosphate and acetate. This is the first committed step in the biosynthetic pathway to...; Region: NagA; cd00854
365659000576	active site
365659000577	dimer interface [polypeptide binding]; other site
365659000578	formaldehyde dehydrogenase (FDH)-like; Region: FDH_like_ADH2; cd08286
365659000579	Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063
365659000580	catalytic Zn binding site [ion binding]; other site
365659000581	structural Zn binding site [ion binding]; other site
365659000582	NAD(P) binding site [chemical binding]; other site
365659000583	Protein of unknown function (DUF1033); Region: DUF1033; pfam06279
365659000584	Type II secretory pathway, ATPase PulE/Tfp pilus assembly pathway, ATPase PilB [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulE; COG2804
365659000585	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
365659000586	Walker A motif; other site
365659000587	ATP binding site [chemical binding]; other site
365659000588	Walker B motif; other site
365659000589	Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482
365659000590	Type II secretory pathway, component PulF [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulF; COG1459
365659000591	Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482
365659000592	Competence protein ComGC [Intracellular trafficking and secretion]; Region: ComGC; COG4537
365659000593	Type II secretory pathway, pseudopilin PulG [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulG; COG2165
365659000594	Type II secretory pathway pseudopilin; Region: PulG; pfam11773
365659000595	Competence protein ComGF [Intracellular trafficking and secretion]; Region: ComGF; COG4940
365659000596	Isocitrate dehydrogenase kinase/phosphatase [Signal transduction mechanisms]; Region: COG4579
365659000597	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
365659000598	Adenine-specific DNA methylase [DNA replication, recombination, and repair]; Region: COG0827
365659000599	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
365659000600	S-adenosylmethionine binding site [chemical binding]; other site
365659000601	acetate kinase A/propionate kinase 2; Reviewed; Region: PRK00180
365659000602	propionate/acetate kinase; Provisional; Region: PRK12379
365659000603	ribonuclease P; Reviewed; Region: rnpA; PRK00499
365659000604	Preprotein translocase subunit YidC [Intracellular trafficking and secretion]; Region: YidC; COG0706
365659000605	membrane protein insertase, YidC/Oxa1 family, C-terminal domain; Region: yidC_oxa1_cterm; TIGR03592
365659000606	Predicted RNA-binding protein [General function prediction only]; Region: Jag; COG1847
365659000607	jag_K homology RNA-binding domain. The KH domain is found in proteins homologous to the Bacillus subtilis protein Jag, which is associated with SpoIIIJ and is necessary for the third stage of sporulation.  The KH motif is a beta-alpha-alpha-beta-beta...; Region: jag_KH; cd02414
365659000608	G-X-X-G motif; other site
365659000609	R3H domain found in proteins homologous to Bacillus subtilus Jag, which is associated with SpoIIIJ. SpoIIIJ is necessary for the third stage of sporulation. The name of the R3H domain comes from the characteristic spacing of the most conserved arginine...; Region: R3H_jag; cd02644
365659000610	RxxxH motif; other site
365659000611	PTS system ascorbate-specific transporter subunit IIC; Reviewed; Region: PRK12997
365659000612	PTS_IIB_ascorbate: subunit IIB of enzyme II (EII) of the L-ascorbate-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is an L-ascorbate-specific permease with two cytoplasmic subunits (IIA and IIB) and a...; Region: PTS_IIB_ascorbate; cd05563
365659000613	active site
365659000614	P-loop; other site
365659000615	phosphorylation site [posttranslational modification]
365659000616	PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211
365659000617	active site
365659000618	phosphorylation site [posttranslational modification]
365659000619	3-Keto-L-gulonate 6-phosphate decarboxylase (KGPDC) and D-arabino-3-hexulose-6-phosphate synthase (HPS). KGPDC catalyzes the formation of L-xylulose 5-phosphate and carbon dioxide from 3-keto-L-gulonate 6-phosphate as part of the anaerobic pathway for...; Region: KGPDC_HPS; cd04726
365659000620	active site
365659000621	dimer interface [polypeptide binding]; other site
365659000622	magnesium binding site [ion binding]; other site
365659000623	putative L-xylulose 5-phosphate 3-epimerase; Reviewed; Region: PRK13210
365659000624	AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cd00019
365659000625	AP (apurinic/apyrimidinic) site pocket; other site
365659000626	DNA interaction; other site
365659000627	Metal-binding active site; metal-binding site
365659000628	L-ribulose-5-phosphate 4-epimerase; Provisional; Region: araD; PRK13145
365659000629	L-ribulose-5-phosphate 4-epimerase; Reviewed; Region: araD; PRK08193
365659000630	intersubunit interface [polypeptide binding]; other site
365659000631	active site
365659000632	Zn2+ binding site [ion binding]; other site
365659000633	Transcriptional antiterminator [Transcription]; Region: BglG; COG3711
365659000634	PRD domain; Region: PRD; pfam00874
365659000635	PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568
365659000636	active site
365659000637	P-loop; other site
365659000638	phosphorylation site [posttranslational modification]
365659000639	putative L-ascorbate 6-phosphate lactonase; Provisional; Region: PRK11709
365659000640	Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220
365659000641	Transketolase [Carbohydrate transport and metabolism]; Region: TktA; COG0021
365659000642	Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012
365659000643	TPP-binding site [chemical binding]; other site
365659000644	dimer interface [polypeptide binding]; other site
365659000645	Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033
365659000646	PYR/PP interface [polypeptide binding]; other site
365659000647	dimer interface [polypeptide binding]; other site
365659000648	TPP binding site [chemical binding]; other site
365659000649	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
365659000650	preprotein translocase subunit YajC; Validated; Region: yajC; PRK06531
365659000651	Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394
365659000652	Low molecular weight phosphatase family; Region: LMWPc; cd00115
365659000653	active site
365659000654	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4642
365659000655	MORN repeat; Region: MORN; cl14787
365659000656	bifunctional acetaldehyde-CoA/alcohol dehydrogenase; Provisional; Region: PRK13805
365659000657	Coenzyme A acylating aldehyde dehydrogenase (ACDH), ALDH family 20-like; Region: ALDH_F20_ACDH; cd07122
365659000658	putative catalytic cysteine [active]
365659000659	C-terminal alcohol dehydrogenase domain of the acetaldehyde dehydrogenase-alcohol dehydrogenase bifunctional two-domain protein (AAD); Region: AAD_C; cd08178
365659000660	putative active site [active]
365659000661	metal binding site [ion binding]; metal-binding site
365659000662	Glyceraldehyde-3-phosphate dehydrogenase/erythrose-4-phosphate dehydrogenase [Carbohydrate transport and metabolism]; Region: GapA; COG0057
365659000663	Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846
365659000664	Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800
365659000665	Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564
365659000666	Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869
365659000667	active site
365659000668	Membrane carboxypeptidase (penicillin-binding protein) [Cell envelope biogenesis, outer membrane]; Region: MrcB; COG0744
365659000669	Transglycosylase; Region: Transgly; pfam00912
365659000670	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760
365659000671	Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826
365659000672	Helix-turn-helix domain; Region: HTH_38; pfam13936
365659000673	Integrase core domain; Region: rve; pfam00665
365659000674	50S ribosomal protein L33; Validated; Region: rpmG; PRK00504
365659000675	Preprotein translocase subunit SecE [Intracellular trafficking and secretion]; Region: SecE; COG0690
365659000676	transcription antitermination protein NusG; Validated; Region: nusG; PRK05609
365659000677	Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891
365659000678	putative homodimer interface [polypeptide binding]; other site
365659000679	NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091
365659000680	heterodimer interface [polypeptide binding]; other site
365659000681	homodimer interface [polypeptide binding]; other site
365659000682	RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937
365659000683	Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826
365659000684	Helix-turn-helix domain; Region: HTH_38; pfam13936
365659000685	Integrase core domain; Region: rve; pfam00665
365659000686	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
365659000687	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
365659000688	Walker A/P-loop; other site
365659000689	ATP binding site [chemical binding]; other site
365659000690	Q-loop/lid; other site
365659000691	ABC transporter signature motif; other site
365659000692	Walker B; other site
365659000693	D-loop; other site
365659000694	H-loop/switch region; other site
365659000695	ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842
365659000696	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585
365659000697	Bacteriorhodopsin-like protein; Region: Bac_rhodopsin; cl02333
365659000698	Histidine kinase; Region: HisKA_3; pfam07730
365659000699	Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518
365659000700	ATP binding site [chemical binding]; other site
365659000701	Mg2+ binding site [ion binding]; other site
365659000702	G-X-G motif; other site
365659000703	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
365659000704	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
365659000705	active site
365659000706	phosphorylation site [posttranslational modification]
365659000707	intermolecular recognition site; other site
365659000708	dimerization interface [polypeptide binding]; other site
365659000709	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
365659000710	DNA binding residues [nucleotide binding]
365659000711	dimerization interface [polypeptide binding]; other site
365659000712	Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826
365659000713	Helix-turn-helix domain; Region: HTH_38; pfam13936
365659000714	Integrase core domain; Region: rve; pfam00665
365659000715	S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368
365659000716	S17 interaction site [polypeptide binding]; other site
365659000717	S8 interaction site; other site
365659000718	16S rRNA interaction site [nucleotide binding]; other site
365659000719	streptomycin interaction site [chemical binding]; other site
365659000720	23S rRNA interaction site [nucleotide binding]; other site
365659000721	aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site
365659000722	30S ribosomal protein S7; Validated; Region: PRK05302
365659000723	elongation factor G; Reviewed; Region: PRK00007
365659000724	Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886
365659000725	G1 box; other site
365659000726	putative GEF interaction site [polypeptide binding]; other site
365659000727	GTP/Mg2+ binding site [chemical binding]; other site
365659000728	Switch I region; other site
365659000729	G2 box; other site
365659000730	G3 box; other site
365659000731	Switch II region; other site
365659000732	G4 box; other site
365659000733	G5 box; other site
365659000734	EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088
365659000735	EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434
365659000736	EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G.  Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713
365659000737	DNA polymerase III PolC; Validated; Region: polC; PRK00448
365659000738	DNA polymerase III polC-type N-terminus; Region: DNA_pol3_alph_N; pfam11490
365659000739	polC_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold nucleic acid binding domain of Bacillus subtilis type C replicative DNA polymerase III alpha subunit (polC). Replication in B. subtilis and Staphylococcus aureus requires two...; Region: polC_OBF; cd04484
365659000740	generic binding surface II; other site
365659000741	generic binding surface I; other site
365659000742	Polymerase and Histidinol Phosphatase domain; Region: PHP; cl17102
365659000743	active site
365659000744	DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127
365659000745	active site
365659000746	catalytic site [active]
365659000747	substrate binding site [chemical binding]; other site
365659000748	Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III at PolC gene; Region: PHP_PolIIIA_POLC; cd07435
365659000749	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3041
365659000750	Thermophilic metalloprotease (M29); Region: Peptidase_M29; pfam02073
365659000751	Leucyl aminopeptidase (aminopeptidase T) [Amino acid transport and metabolism]; Region: AmpS; COG2309
365659000752	16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187
365659000753	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
365659000754	RNA binding surface [nucleotide binding]; other site
365659000755	Pseudouridine synthase, Escherichia coli RsuA like; Region: PseudoU_synth_RsuA; cd02553
365659000756	active site
365659000757	uracil binding [chemical binding]; other site
365659000758	Peptidase C1B subfamily (MEROPS database nomenclature); composed of eukaryotic bleomycin hydrolases (BH) and bacterial aminopeptidases C (pepC). The proteins of this subfamily contain a large insert relative to the C1A peptidase (papain) subfamily. BH is...; Region: Peptidase_C1B; cd00585
365659000759	trimer interface [polypeptide binding]; other site
365659000760	active site
365659000761	G bulge; other site
365659000762	Helix-turn-helix domain of transposase family ISL3; Region: HTH_Tnp_ISL3; pfam13542
365659000763	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464
365659000764	Transposase; Region: DDE_Tnp_ISL3; pfam01610
365659000765	Protein of unknown function (DUF4230); Region: DUF4230; pfam14014
365659000766	Leucine rich repeats (6 copies); Region: LRR_5; pfam13306
365659000767	Phosphotransferase system, mannose/fructose/N-acetylgalactosamine-specific component IID [Carbohydrate transport and metabolism]; Region: ManZ; COG3716
365659000768	PTS system mannose-specific transporter subunit IIC; Provisional; Region: PRK15065
365659000769	PTS system mannose-specific transporter subunits IIAB; Provisional; Region: PRK15088
365659000770	PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006
365659000771	active pocket/dimerization site; other site
365659000772	active site
365659000773	phosphorylation site [posttranslational modification]
365659000774	PTS_IIB, PTS system, Mannose/sorbose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_man; cd00001
365659000775	active site
365659000776	phosphorylation site [posttranslational modification]
365659000777	ethanol-active dehydrogenase/acetaldehyde-active reductase; Provisional; Region: PRK09422
365659000778	Cinnamyl alcohol dehydrogenases (CAD); Region: CAD3; cd08297
365659000779	NAD binding site [chemical binding]; other site
365659000780	substrate binding site [chemical binding]; other site
365659000781	catalytic Zn binding site [ion binding]; other site
365659000782	tetramer interface [polypeptide binding]; other site
365659000783	structural Zn binding site [ion binding]; other site
365659000784	Predicted hydrolases of the HAD superfamily [General function prediction only]; Region: Cof; COG0561
365659000785	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
365659000786	active site
365659000787	motif I; other site
365659000788	motif II; other site
365659000789	Xanthine/uracil/vitamin C permease [Nucleotide transport and    metabolism]; Region: COG2252
365659000790	Sulfate transporter family; Region: Sulfate_transp; pfam00916
365659000791	Predicted metal-dependent membrane protease [General function prediction only]; Region: COG1266
365659000792	DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739
365659000793	dihydropteroate synthase; Region: DHPS; TIGR01496
365659000794	substrate binding pocket [chemical binding]; other site
365659000795	dimer interface [polypeptide binding]; other site
365659000796	inhibitor binding site; inhibition site
365659000797	Folylpolyglutamate synthase [Coenzyme metabolism]; Region: FolC; COG0285
365659000798	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
365659000799	GTP cyclohydrolase I (GTP-CH-I) catalyzes the conversion of GTP into dihydroneopterin triphosphate.  The enzyme product is the precursor of tetrahydrofolate in eubacteria, fungi, and plants and of the folate analogs in methanogenic bacteria.  In...; Region: GTP_cyclohydro1; cd00642
365659000800	homodecamer interface [polypeptide binding]; other site
365659000801	GTP cyclohydrolase I; Provisional; Region: PLN03044
365659000802	active site
365659000803	putative catalytic site residues [active]
365659000804	zinc binding site [ion binding]; other site
365659000805	GTP-CH-I/GFRP interaction surface; other site
365659000806	Dihydroneopterin aldolase (DHNA) and 7,8-dihydroneopterin triphosphate epimerase domain (DHNTPE); these enzymes have been designated folB and folX, respectively. Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and...; Region: DHNA_DHNTPE; cd00534
365659000807	homooctamer interface [polypeptide binding]; other site
365659000808	active site
365659000809	7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483
365659000810	catalytic center binding site [active]
365659000811	ATP binding site [chemical binding]; other site
365659000812	Staphylococcal protein of unknown function (DUF960); Region: DUF960; pfam06124
365659000813	catabolite control protein A; Region: ccpA; TIGR01481
365659000814	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
365659000815	DNA binding site [nucleotide binding]
365659000816	domain linker motif; other site
365659000817	Ligand-binding domain of the catabolite control protein A (CcpA), which functions as the major transcriptional regulator of carbon catabolite repression/regulation; Region: PBP1_CcpA_like; cd06298
365659000818	dimerization interface [polypeptide binding]; other site
365659000819	effector binding site; other site
365659000820	Type II (periplasmic) bacterial L-asparaginase; Region: L-asparaginase_II; cd08964
365659000821	active site
365659000822	homotetramer interface [polypeptide binding]; other site
365659000823	homodimer interface [polypeptide binding]; other site
365659000824	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
365659000825	haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282
365659000826	active site
365659000827	motif I; other site
365659000828	motif II; other site
365659000829	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
365659000830	Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in Exiguobacterium sibiricum YP_001813558.1 protein and its bacterial homologs; Region: NTP-PPase_YP_001813558; cd11545
365659000831	putative nucleotide binding site [chemical binding]; other site
365659000832	putative metal binding site [ion binding]; other site
365659000833	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
365659000834	Ligand Binding Site [chemical binding]; other site
365659000835	aminotransferase AlaT; Validated; Region: PRK09265
365659000836	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
365659000837	pyridoxal 5'-phosphate binding site [chemical binding]; other site
365659000838	homodimer interface [polypeptide binding]; other site
365659000839	catalytic residue [active]
365659000840	Ribosomal protein L34; Region: Ribosomal_L34; cl00370
365659000841	ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166
365659000842	The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504
365659000843	peptide binding site [polypeptide binding]; other site
365659000844	Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531
365659000845	K+ potassium transporter; Region: K_trans; cl15781
365659000846	Predicted metal-dependent hydrolases with the TIM-barrel fold [General function prediction only]; Region: COG1099
365659000847	TatD like proteins;  E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310
365659000848	active site
365659000849	ribonuclease M5; Region: 5S_RNA_mat_M5; TIGR00334
365659000850	TOPRIM_ RNase M5_like: The topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain found in Ribonuclease M5: (RNase M5) and other small primase-like proteins from bacteria and archaea.  RNase M5 catalyzes the maturation of 5S rRNA in low...; Region: TOPRIM_RNase_M5_like; cd01027
365659000851	putative active site [active]
365659000852	putative metal binding site [ion binding]; other site
365659000853	Domain of unknown function (DUF4093); Region: DUF4093; pfam13331
365659000854	16S ribosomal RNA methyltransferase KsgA/Dim1 family protein; Reviewed; Region: ksgA; PRK00274
365659000855	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
365659000856	S-adenosylmethionine binding site [chemical binding]; other site
365659000857	GTPase RsgA; Reviewed; Region: PRK00098
365659000858	S1_YloQ_GTPase: YloQ GTase family (also known as YjeQ and CpgA), S1-like RNA-binding domain. Proteins in the YloQ GTase family bind the ribosome and have GTPase activity. The precise role of this family is unknown. The protein structure is composed of...; Region: S1_YloQ_GTPase; cd04466
365659000859	RNA binding site [nucleotide binding]; other site
365659000860	homodimer interface [polypeptide binding]; other site
365659000861	Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854
365659000862	GTPase/Zn-binding domain interface [polypeptide binding]; other site
365659000863	GTP/Mg2+ binding site [chemical binding]; other site
365659000864	G4 box; other site
365659000865	G5 box; other site
365659000866	G1 box; other site
365659000867	Switch I region; other site
365659000868	G2 box; other site
365659000869	G3 box; other site
365659000870	Switch II region; other site
365659000871	Pentose-5-phosphate-3-epimerase [Carbohydrate transport and metabolism]; Region: Rpe; COG0036
365659000872	Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429
365659000873	substrate binding site [chemical binding]; other site
365659000874	hexamer interface [polypeptide binding]; other site
365659000875	metal binding site [ion binding]; metal-binding site
365659000876	Thiamine pyrophosphokinase [Coenzyme metabolism]; Region: THI80; COG1564
365659000877	Thiamine pyrophosphokinase; Region: TPK; cd07995
365659000878	active site
365659000879	dimerization interface [polypeptide binding]; other site
365659000880	thiamine binding site [chemical binding]; other site
365659000881	Predicted nuclease of restriction endonuclease-like fold, RmuC family [General function prediction only]; Region: COG1322
365659000882	RmuC family; Region: RmuC; pfam02646
365659000883	Predicted HD-superfamily hydrolase [General function prediction only]; Region: COG3481
365659000884	YhaM_OBF_like: A subfamily of OB folds similar to that found in Bacillus subtilis YhaM and Staphylococcus aureus cmp-binding factor-1 (SaCBF1). Both these proteins are 3'-to-5'exoribonucleases. YhaM requires Mn2+ or Co2+ for activity and is...; Region: YhaM_OBF_like; cd04492
365659000885	generic binding surface II; other site
365659000886	generic binding surface I; other site
365659000887	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
365659000888	Zn2+ binding site [ion binding]; other site
365659000889	Mg2+ binding site [ion binding]; other site
365659000890	Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826
365659000891	Helix-turn-helix domain; Region: HTH_38; pfam13936
365659000892	Integrase core domain; Region: rve; pfam00665
365659000893	pur operon repressor; Provisional; Region: PRK09213
365659000894	Bacterial purine repressor, N-terminal; Region: PuR_N; pfam09182
365659000895	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
365659000896	active site
365659000897	Diaminopimelate decarboxylase [Amino acid transport and metabolism]; Region: LysA; COG0019
365659000898	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828
365659000899	active site
365659000900	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
365659000901	substrate binding site [chemical binding]; other site
365659000902	catalytic residues [active]
365659000903	dimer interface [polypeptide binding]; other site
365659000904	pyruvate formate-lyase 1-activating enzyme; Region: PFLA; TIGR02493
365659000905	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
365659000906	FeS/SAM binding site; other site
365659000907	ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555
365659000908	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
365659000909	Walker A/P-loop; other site
365659000910	ATP binding site [chemical binding]; other site
365659000911	Q-loop/lid; other site
365659000912	ABC transporter signature motif; other site
365659000913	Walker B; other site
365659000914	D-loop; other site
365659000915	H-loop/switch region; other site
365659000916	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
365659000917	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
365659000918	active site
365659000919	phosphorylation site [posttranslational modification]
365659000920	intermolecular recognition site; other site
365659000921	dimerization interface [polypeptide binding]; other site
365659000922	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
365659000923	DNA binding site [nucleotide binding]
365659000924	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
365659000925	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
365659000926	dimer interface [polypeptide binding]; other site
365659000927	phosphorylation site [posttranslational modification]
365659000928	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
365659000929	Mg2+ binding site [ion binding]; other site
365659000930	G-X-G motif; other site
365659000931	OxaA-like protein precursor; Provisional; Region: PRK02463
365659000932	membrane protein insertase, YidC/Oxa1 family, C-terminal domain; Region: yidC_oxa1_cterm; TIGR03592
365659000933	rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566
365659000934	RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; smart00967
365659000935	SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588
365659000936	Integral membrane protein, interacts with FtsH [General function prediction only]; Region: COG0670
365659000937	Bacterial BAX inhibitor (BI)-1/YccA-like proteins; Region: BI-1-like_bacterial; cd10432
365659000938	Asparagine synthetase (aspartate-ammonia ligase) (AsnA) catalyses the conversion of L-aspartate to L-asparagine in the presence of ATP and ammonia.  AsnA is a homodimeric enzyme which is structurally similiar to the catalytic core domain of class II...; Region: AsnA; cd00645
365659000939	dimer interface [polypeptide binding]; other site
365659000940	active site
365659000941	Conserved hypothetical protein 95; Region: Cons_hypoth95; pfam03602
365659000942	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
365659000943	S-adenosylmethionine binding site [chemical binding]; other site
365659000944	Phosphopantetheine adenylyltransferase [Coenzyme metabolism]; Region: CoaD; COG0669
365659000945	Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163
365659000946	active site
365659000947	(T/H)XGH motif; other site
365659000948	Predicted secreted protein containing a PDZ domain [Signal transduction mechanisms]; Region: SdrC; COG3480
365659000949	PDZ domain, also called DHR (Dlg homologous region) or GLGF (after a conserved sequence motif). Many PDZ domains bind C-terminal polypeptides, though binding to internal (non-C-terminal) polypeptides and even to lipids has been demonstrated; Region: PDZ; cl00117
365659000950	protein binding site [polypeptide binding]; other site
365659000951	Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362
365659000952	UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072
365659000953	UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555
365659000954	hinge; other site
365659000955	active site
365659000956	DNA-directed RNA polymerase subunit beta; Region: EpuA; pfam11772
365659000957	DNA/RNA non-specific endonuclease; Region: Endonuclease_NS; smart00892
365659000958	DNA/RNA non-specific endonuclease; Region: Endonuclease_NS; pfam01223
365659000959	Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253
365659000960	Domain of unknown function DUF21; Region: DUF21; pfam01595
365659000961	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590
365659000962	Transporter associated domain; Region: CorC_HlyC; smart01091
365659000963	ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166
365659000964	The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504
365659000965	peptide binding site [polypeptide binding]; other site
365659000966	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601
365659000967	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
365659000968	dimer interface [polypeptide binding]; other site
365659000969	conserved gate region; other site
365659000970	putative PBP binding loops; other site
365659000971	ABC-ATPase subunit interface; other site
365659000972	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173
365659000973	N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911
365659000974	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
365659000975	dimer interface [polypeptide binding]; other site
365659000976	conserved gate region; other site
365659000977	putative PBP binding loops; other site
365659000978	ABC-ATPase subunit interface; other site
365659000979	ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444
365659000980	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
365659000981	Walker A/P-loop; other site
365659000982	ATP binding site [chemical binding]; other site
365659000983	Q-loop/lid; other site
365659000984	ABC transporter signature motif; other site
365659000985	Walker B; other site
365659000986	D-loop; other site
365659000987	H-loop/switch region; other site
365659000988	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
365659000989	ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124
365659000990	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
365659000991	Walker A/P-loop; other site
365659000992	ATP binding site [chemical binding]; other site
365659000993	Q-loop/lid; other site
365659000994	ABC transporter signature motif; other site
365659000995	Walker B; other site
365659000996	D-loop; other site
365659000997	H-loop/switch region; other site
365659000998	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352
365659000999	Type I periplasmic ligand-binding domain of uncharacterized ABC-type transport systems that are predicted to be involved in the uptake of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_uncharacterized_transporter; cd06325
365659001000	Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407
365659001001	zinc binding site [ion binding]; other site
365659001002	putative ligand binding site [chemical binding]; other site
365659001003	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
365659001004	Transmembrane subunit (TM) of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which are involved in the uptake of branched-chain amino acids (AAs), as well as TMs of transporters involved in the uptake of...; Region: TM_PBP1_branched-chain-AA_like; cd06574
365659001005	TM-ABC transporter signature motif; other site
365659001006	ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: PhnK; COG1101
365659001007	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
365659001008	Walker A/P-loop; other site
365659001009	ATP binding site [chemical binding]; other site
365659001010	Q-loop/lid; other site
365659001011	ABC transporter signature motif; other site
365659001012	Walker B; other site
365659001013	D-loop; other site
365659001014	H-loop/switch region; other site
365659001015	alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403
365659001016	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3763
365659001017	glutamate racemase; Provisional; Region: PRK00865
365659001018	putative deoxyribonucleotide triphosphate pyrophosphatase/unknown domain fusion protein; Reviewed; Region: PRK02491
365659001019	NTPase/HAM1.  This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515
365659001020	active site
365659001021	dimerization interface [polypeptide binding]; other site
365659001022	Escherichia coli YfcE and related proteins, metallophosphatase domain; Region: MPP_YfcE; cd00841
365659001023	active site
365659001024	metal binding site [ion binding]; metal-binding site
365659001025	homotetramer interface [polypeptide binding]; other site
365659001026	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_30; cd04643
365659001027	FOG: CBS domain [General function prediction only]; Region: COG0517
365659001028	site-specific tyrosine recombinase XerD-like protein; Reviewed; Region: xerD; PRK02436
365659001029	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
365659001030	active site
365659001031	DNA binding site [nucleotide binding]
365659001032	Int/Topo IB signature motif; other site
365659001033	segregation and condensation protein A; Reviewed; Region: scpA; PRK00104
365659001034	segregation and condensation protein B; Reviewed; Region: scpB; PRK00135
365659001035	16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187
365659001036	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
365659001037	RNA binding surface [nucleotide binding]; other site
365659001038	Pseudouridine synthases, RsuA subfamily; Region: PseudoU_synth_RsuA_like; cd02870
365659001039	active site
365659001040	hypothetical protein; Validated; Region: PRK00041
365659001041	UDP-glucose 4-epimerase [Cell envelope biogenesis, outer membrane]; Region: GalE; COG1087
365659001042	UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247
365659001043	NAD binding site [chemical binding]; other site
365659001044	homodimer interface [polypeptide binding]; other site
365659001045	active site
365659001046	substrate binding site [chemical binding]; other site
365659001047	Cellulase M and related proteins [Carbohydrate transport and metabolism]; Region: FrvX; COG1363
365659001048	M42 Peptidases, also known as glutamyl aminopeptidase family; Region: M42; cd05638
365659001049	oligomer interface [polypeptide binding]; other site
365659001050	active site
365659001051	metal binding site [ion binding]; metal-binding site
365659001052	Enterocin A Immunity; Region: EntA_Immun; pfam08951
365659001053	Na+/phosphate symporter [Inorganic ion transport and metabolism]; Region: NptA; COG1283
365659001054	Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690
365659001055	Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690
365659001056	PhoU domain; Region: PhoU; pfam01895
365659001057	PhoU domain; Region: PhoU; pfam01895
365659001058	Gram-positive signal peptide, YSIRK family; Region: YSIRK_signal; TIGR01168
365659001059	Endo-beta-N-acetylglucosaminidase D [Carbohydrate transport and metabolism]; Region: COG4724
365659001060	Glycosyl hydrolase family 85; Region: Glyco_hydro_85; pfam03644
365659001061	active site
365659001062	Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes; Region: FA58C; cl12042
365659001063	Bacterial Ig-like domain (group 3); Region: Big_3; pfam07523
365659001064	Bacterial Ig-like domain (group 3); Region: Big_3; pfam07523
365659001065	G5 domain; Region: G5; pfam07501
365659001066	G5 domain; Region: G5; pfam07501
365659001067	phosphoglycerate kinase; Provisional; Region: pgk; PRK00073
365659001068	Phosphoglycerate kinase; Region: PGK; pfam00162
365659001069	substrate binding site [chemical binding]; other site
365659001070	hinge regions; other site
365659001071	ADP binding site [chemical binding]; other site
365659001072	catalytic site [active]
365659001073	Predicted membrane protein [Function unknown]; Region: COG4129
365659001074	Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515
365659001075	Helix-Turn-Helix DNA binding domain of GlnR-like transcription regulators; Region: HTH_GlnR-like; cd01105
365659001076	MerR HTH family regulatory protein; Region: MerR_1; pfam13411
365659001077	DNA binding residues [nucleotide binding]
365659001078	putative dimer interface [polypeptide binding]; other site
365659001079	Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174
365659001080	Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951
365659001081	Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120
365659001082	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
365659001083	Transcriptional regulator PadR-like family; Region: PadR; pfam03551
365659001084	Protein of unknown function (DUF2812); Region: DUF2812; pfam11193
365659001085	Protein of unknown function (DUF2812); Region: DUF2812; pfam11193
365659001086	heat-inducible transcription repressor; Provisional; Region: hrcA; PRK00082
365659001087	Winged helix-turn-helix transcription repressor, HrcA DNA-binding; Region: HrcA_DNA-bdg; pfam03444
365659001088	Molecular chaperone GrpE (heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: GrpE; COG0576
365659001089	GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446
365659001090	dimer interface [polypeptide binding]; other site
365659001091	hsp70 (ATPase domain) interactions [polypeptide binding]; other site
365659001092	molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290
365659001093	Nucleotide-binding domain of human HSPA9 and similar proteins; Region: HSPA9-Ssq1-like_NBD; cd10234
365659001094	nucleotide binding site [chemical binding]; other site
365659001095	NEF interaction site [polypeptide binding]; other site
365659001096	SBD interface [polypeptide binding]; other site
365659001097	Putative intracellular protease/amidase [General function prediction only]; Region: ThiJ; COG0693
365659001098	Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020
365659001099	Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020
365659001100	chaperone protein DnaJ; Provisional; Region: PRK14276
365659001101	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257
365659001102	HSP70 interaction site [polypeptide binding]; other site
365659001103	C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cl03262
365659001104	substrate binding site [polypeptide binding]; other site
365659001105	Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719
365659001106	Zn binding sites [ion binding]; other site
365659001107	C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747
365659001108	dimer interface [polypeptide binding]; other site
365659001109	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3666
365659001110	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
365659001111	Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751
365659001112	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
365659001113	HINT (histidine triad nucleotide-binding protein) subgroup: Members of this CD belong to the superfamily of histidine triad hydrolases that act on alpha-phosphate of ribonucleotides. This subgroup includes members from all three forms of cellular life; Region: HINT_subgroup; cd01277
365659001114	HIT family signature motif; other site
365659001115	catalytic residue [active]
365659001116	ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555
365659001117	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
365659001118	Walker A/P-loop; other site
365659001119	ATP binding site [chemical binding]; other site
365659001120	Q-loop/lid; other site
365659001121	ABC transporter signature motif; other site
365659001122	Walker B; other site
365659001123	D-loop; other site
365659001124	H-loop/switch region; other site
365659001125	Bacterial ABC transporter protein EcsB; Region: EcsB; cl11542
365659001126	Bacterial ABC transporter protein EcsB; Region: EcsB; cl11542
365659001127	Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279
365659001128	LytTr DNA-binding domain; Region: LytTR; pfam04397
365659001129	Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279
365659001130	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
365659001131	active site
365659001132	phosphorylation site [posttranslational modification]
365659001133	intermolecular recognition site; other site
365659001134	dimerization interface [polypeptide binding]; other site
365659001135	LytTr DNA-binding domain; Region: LytTR; pfam04397
365659001136	Predicted signal transduction protein with a C-terminal ATPase domain [Signal transduction mechanisms]; Region: COG2972
365659001137	Fibrinogen alpha/beta chain family; Region: Fib_alpha; pfam08702
365659001138	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
365659001139	ATP binding site [chemical binding]; other site
365659001140	Mg2+ binding site [ion binding]; other site
365659001141	G-X-G motif; other site
365659001142	CAAX protease self-immunity; Region: Abi; pfam02517
365659001143	Phosphotransferase enzyme family; Region: APH; pfam01636
365659001144	Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120
365659001145	substrate binding site [chemical binding]; other site
365659001146	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
365659001147	S-adenosylmethionine binding site [chemical binding]; other site
365659001148	ribosome maturation protein RimP; Reviewed; Region: PRK00092
365659001149	Bacillus subtilis YxlS-like, C-terminal domain; Region: YlxS_C; cd01734
365659001150	putative oligomer interface [polypeptide binding]; other site
365659001151	putative RNA binding site [nucleotide binding]; other site
365659001152	transcription elongation factor NusA; Provisional; Region: nusA; PRK12327
365659001153	NusA N-terminal domain; Region: NusA_N; pfam08529
365659001154	S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455
365659001155	RNA binding site [nucleotide binding]; other site
365659001156	homodimer interface [polypeptide binding]; other site
365659001157	NusA-like KH domain; Region: KH_5; pfam13184
365659001158	NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134
365659001159	G-X-X-G motif; other site
365659001160	Ylxr homologs; group of conserved hypothetical bacterial proteins of unknown function; structure revealed putative RNA binding cleft; proteins are encoded by an operon that includes other proteins involved in transcription and/or translation; Region: YlxR; cd00279
365659001161	putative RNA binding cleft [nucleotide binding]; other site
365659001162	hypothetical protein; Provisional; Region: PRK07283
365659001163	Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760
365659001164	translation initiation factor IF-2; Validated; Region: infB; PRK05306
365659001165	Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760
365659001166	Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887
365659001167	G1 box; other site
365659001168	putative GEF interaction site [polypeptide binding]; other site
365659001169	GTP/Mg2+ binding site [chemical binding]; other site
365659001170	Switch I region; other site
365659001171	G2 box; other site
365659001172	G3 box; other site
365659001173	Switch II region; other site
365659001174	G4 box; other site
365659001175	G5 box; other site
365659001176	This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702
365659001177	Translation-initiation factor 2; Region: IF-2; pfam11987
365659001178	mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692
365659001179	ribosome-binding factor A; Validated; Region: rbfA; PRK00521
365659001180	Domain of unknown function (DUF1858); Region: DUF1858; pfam08984
365659001181	Uncharacterized conserved protein [Function unknown]; Region: COG2461
365659001182	Family of unknown function (DUF438); Region: DUF438; pfam04282
365659001183	Hemerythrin HHE cation binding domain; Region: Hemerythrin; pfam01814
365659001184	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459
365659001185	putative active site [active]
365659001186	heme pocket [chemical binding]; other site
365659001187	Domain of unknown function (DUF1912); Region: DUF1912; pfam08930
365659001188	hypothetical protein; Provisional; Region: PRK07758
365659001189	Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family [General function prediction only]; Region: COG1853
365659001190	Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670
365659001191	Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583
365659001192	AAA domain; Region: AAA_18; pfam13238
365659001193	valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729
365659001194	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
365659001195	active site
365659001196	HIGH motif; other site
365659001197	nucleotide binding site [chemical binding]; other site
365659001198	Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603
365659001199	catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817
365659001200	active site
365659001201	KMSKS motif; other site
365659001202	Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962
365659001203	tRNA binding surface [nucleotide binding]; other site
365659001204	anticodon binding site; other site
365659001205	Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458
365659001206	Site-specific DNA methylase [DNA replication, recombination, and repair]; Region: Dcm; COG0270
365659001207	Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315
365659001208	cofactor binding site; other site
365659001209	DNA binding site [nucleotide binding]
365659001210	substrate interaction site [chemical binding]; other site
365659001211	Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315
365659001212	Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c_3; pfam13589
365659001213	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
365659001214	ATP binding site [chemical binding]; other site
365659001215	Mg2+ binding site [ion binding]; other site
365659001216	G-X-G motif; other site
365659001217	Protein involved in cell division [Cell division and chromosome partitioning]; Region: Fic; COG2184
365659001218	Fic/DOC family; Region: Fic; pfam02661
365659001219	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4951
365659001220	DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061
365659001221	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
365659001222	ATP binding site [chemical binding]; other site
365659001223	putative Mg++ binding site [ion binding]; other site
365659001224	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
365659001225	nucleotide binding region [chemical binding]; other site
365659001226	ATP-binding site [chemical binding]; other site
365659001227	C-terminal putative phospholipase D-like domain of uncharacterized prokaryotic HKD family nucleases fused to DEAD/DEAH box helicases; Region: PLDc_C_DEXD_like; cd09126
365659001228	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
365659001229	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
365659001230	WHG domain; Region: WHG; pfam13305
365659001231	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
365659001232	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
365659001233	Walker A/P-loop; other site
365659001234	ATP binding site [chemical binding]; other site
365659001235	Q-loop/lid; other site
365659001236	ABC transporter signature motif; other site
365659001237	Walker B; other site
365659001238	D-loop; other site
365659001239	H-loop/switch region; other site
365659001240	Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826
365659001241	Helix-turn-helix domain; Region: HTH_38; pfam13936
365659001242	Integrase core domain; Region: rve; pfam00665
365659001243	DNA-directed RNA polymerase delta subunit; Region: RNA_pol_delta; pfam05066
365659001244	CTP synthetase; Validated; Region: pyrG; PRK05380
365659001245	CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113
365659001246	Catalytic site [active]
365659001247	active site
365659001248	UTP binding site [chemical binding]; other site
365659001249	Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746
365659001250	active site
365659001251	putative oxyanion hole; other site
365659001252	catalytic triad [active]
365659001253	FOG: Glucan-binding domain (YG repeat) [General function prediction only]; Region: COG5263
365659001254	TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947
365659001255	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
365659001256	catalytic residues [active]
365659001257	tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain.  PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796
365659001258	putative tRNA-binding site [nucleotide binding]; other site
365659001259	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
365659001260	Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221
365659001261	NAD(P) binding site [chemical binding]; other site
365659001262	active site
365659001263	inducible prophage phiB6
365659001264	Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961
365659001265	Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768
365659001266	catalytic residues [active]
365659001267	catalytic nucleophile [active]
365659001268	Presynaptic Site I dimer interface [polypeptide binding]; other site
365659001269	Synaptic Antiparallel dimer interface [polypeptide binding]; other site
365659001270	Synaptic Flat tetramer interface [polypeptide binding]; other site
365659001271	Synaptic Site I dimer interface [polypeptide binding]; other site
365659001272	DNA binding site [nucleotide binding]
365659001273	Recombinase; Region: Recombinase; pfam07508
365659001274	Recombinase zinc beta ribbon domain; Region: Zn_ribbon_recom; pfam13408
365659001275	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
365659001276	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
365659001277	non-specific DNA binding site [nucleotide binding]; other site
365659001278	salt bridge; other site
365659001279	sequence-specific DNA binding site [nucleotide binding]; other site
365659001280	Predicted transcriptional regulator [Transcription]; Region: COG2932
365659001281	Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529
365659001282	Catalytic site [active]
365659001283	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
365659001284	non-specific DNA binding site [nucleotide binding]; other site
365659001285	salt bridge; other site
365659001286	sequence-specific DNA binding site [nucleotide binding]; other site
365659001287	type I secretion system ABC transporter, HlyB family; Region: type_I_sec_HlyB; TIGR01846
365659001288	NAD-dependent deacetylase; Provisional; Region: PRK00481
365659001289	Siphovirus Gp157; Region: Sipho_Gp157; pfam05565
365659001290	phage nucleotide-binding protein; Region: phage_P_loop; TIGR01618
365659001291	AAA domain; Region: AAA_24; pfam13479
365659001292	DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061
365659001293	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
365659001294	ATP binding site [chemical binding]; other site
365659001295	putative Mg++ binding site [ion binding]; other site
365659001296	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
365659001297	nucleotide binding region [chemical binding]; other site
365659001298	ATP-binding site [chemical binding]; other site
365659001299	Protein of unknown function (DUF669); Region: DUF669; pfam05037
365659001300	Prim_Pol: Primase-polymerase (primpol) domain of the type found in bifunctional replicases from archaeal plasmids, including ORF904 protein of the crenarchaeal plasmid pRN1 from Sulfolobus islandicus (pRN1 primpol). These primpol domains belong to the...; Region: Prim_Pol; cd04859
365659001301	polymerase nucleotide-binding site; other site
365659001302	DNA-binding residues [nucleotide binding]; DNA binding site
365659001303	nucleotide binding site [chemical binding]; other site
365659001304	primase nucleotide-binding site [nucleotide binding]; other site
365659001305	Primase C terminal 1 (PriCT-1); Region: PriCT_1; pfam08708
365659001306	D5 N terminal like; Region: D5_N; smart00885
365659001307	phage/plasmid primase, P4 family, C-terminal domain; Region: primase_Cterm; TIGR01613
365659001308	Poxvirus D5 protein-like; Region: Pox_D5; pfam03288
365659001309	VRR-NUC domain; Region: VRR_NUC; pfam08774
365659001310	Protein of unknown function (DUF1642); Region: DUF1642; pfam07852
365659001311	Protein of unknown function (DUF1372); Region: DUF1372; pfam07116
365659001312	Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in a group of uncharacterized proteins from bacteria and archaea; Region: NTP-PPase_u3; cd11540
365659001313	putative metal binding site [ion binding]; other site
365659001314	Protein of unknwon function (DUF3310); Region: DUF3310; pfam11753
365659001315	PemK-like protein; Region: PemK; pfam02452
365659001316	Antidote-toxin recognition MazE; Region: Antitoxin-MazE; cl00877
365659001317	phage transcriptional regulator, ArpU family; Region: phage_arpU; TIGR01637
365659001318	Terminase small subunit; Region: Terminase_2; pfam03592
365659001319	Phage terminase large subunit; Region: Terminase_3; cl12054
365659001320	Terminase-like family; Region: Terminase_6; pfam03237
365659001321	phage portal protein, SPP1 family; Region: portal_SPP1; TIGR01538
365659001322	Phage portal protein, SPP1 Gp6-like; Region: Phage_prot_Gp6; pfam05133
365659001323	Phage Mu protein F like protein; Region: Phage_Mu_F; cl10072
365659001324	VIP2; A family of actin-ADP-ribosylating toxin. A member of the Bacillus-prodiced vegetative insecticidal proteins (VIPs) possesses high specificity against the major insect pest, corn rootworms, and belongs to a classs of binary toxins and regulators of...; Region: VIP2; cl00173
365659001325	active site
365659001326	conformational flexibility of ligand binding pocket; other site
365659001327	ADP-ribosylating toxin turn-turn motif; other site
365659001328	Phage minor structural protein GP20; Region: Phage_GP20; pfam06810
365659001329	Phage tail sheath protein; Region: Phage_sheath_1; pfam04984
365659001330	Protein of unknown function (DUF2001); Region: DUF2001; pfam09393
365659001331	Phage XkdN-like protein; Region: XkdN; pfam08890
365659001332	tape measure domain; Region: tape_meas_nterm; TIGR02675
365659001333	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
365659001334	Protein of unknown function (DUF2577); Region: DUF2577; pfam10844
365659001335	Protein of unknown function (DUF2634); Region: DUF2634; pfam10934
365659001336	Uncharacterized homolog of phage Mu protein gp47 [Function unknown]; Region: XkdT; COG3299
365659001337	Uncharacterized protein conserved in bacteria (DUF2313); Region: DUF2313; cl01542
365659001338	phosphoribosylformylglycinamidine synthase; Provisional; Region: PLN03206
365659001339	Phage holin protein (Holin_LLH); Region: Holin_LLH; pfam09682
365659001340	FOG: Glucan-binding domain (YG repeat) [General function prediction only]; Region: COG5263
365659001341	Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583
365659001342	amidase catalytic site [active]
365659001343	Zn binding residues [ion binding]; other site
365659001344	substrate binding site [chemical binding]; other site
365659001345	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3666
365659001346	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
365659001347	Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751
365659001348	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
365659001349	SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496
365659001350	dimer interface [polypeptide binding]; other site
365659001351	Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629
365659001352	ssDNA binding site [nucleotide binding]; other site
365659001353	tetramer (dimer of dimers) interface [polypeptide binding]; other site
365659001354	Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320
365659001355	oligomerisation interface [polypeptide binding]; other site
365659001356	mobile loop; other site
365659001357	roof hairpin; other site
365659001358	chaperonin GroEL; Reviewed; Region: groEL; PRK12849
365659001359	GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344
365659001360	ring oligomerisation interface [polypeptide binding]; other site
365659001361	ATP/Mg binding site [chemical binding]; other site
365659001362	stacking interactions; other site
365659001363	hinge regions; other site
365659001364	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1636
365659001365	Methyltransferase domain; Region: Methyltransf_31; pfam13847
365659001366	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
365659001367	S-adenosylmethionine binding site [chemical binding]; other site
365659001368	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
365659001369	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
365659001370	non-specific DNA binding site [nucleotide binding]; other site
365659001371	salt bridge; other site
365659001372	sequence-specific DNA binding site [nucleotide binding]; other site
365659001373	transcriptional activator, Rgg/GadR/MutR family, C-terminal domain; Region: RGG_Cterm; TIGR01716
365659001374	hypothetical protein; Provisional; Region: PRK13662
365659001375	recombination regulator RecX; Provisional; Region: recX; PRK14135
365659001376	SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase [Translation, ribosomal structure and biogenesis]; Region: TrmA; COG2265
365659001377	TRAM domain; Region: TRAM; cl01282
365659001378	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
365659001379	S-adenosylmethionine binding site [chemical binding]; other site
365659001380	bifunctional biotin--[acetyl-CoA-carboxylase] synthetase/biotin operon repressor; Provisional; Region: PRK11886
365659001381	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
365659001382	DNA-binding site [nucleotide binding]; DNA binding site
365659001383	Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; pfam03099
365659001384	Biotin protein ligase C terminal domain; Region: BPL_C; pfam02237
365659001385	Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826
365659001386	Helix-turn-helix domain; Region: HTH_38; pfam13936
365659001387	Integrase core domain; Region: rve; pfam00665
365659001388	Lipid A core - O-antigen ligase and related enzymes [Cell envelope biogenesis, outer membrane]; Region: RfaL; COG3307
365659001389	O-antigen ligase like membrane protein; Region: O-antigen_lig; pfam13425
365659001390	MarR family; Region: MarR_2; cl17246
365659001391	ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126
365659001392	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
365659001393	Walker A/P-loop; other site
365659001394	ATP binding site [chemical binding]; other site
365659001395	Q-loop/lid; other site
365659001396	ABC transporter signature motif; other site
365659001397	Walker B; other site
365659001398	D-loop; other site
365659001399	H-loop/switch region; other site
365659001400	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
365659001401	dimer interface [polypeptide binding]; other site
365659001402	conserved gate region; other site
365659001403	ABC-ATPase subunit interface; other site
365659001404	Periplasmic glycine betaine/choline-binding (lipo)protein of an ABC-type transport system (osmoprotectant binding protein) [Cell envelope biogenesis, outer membrane]; Region: OpuBC; COG1732
365659001405	ABC-type proline/glycine betaine transport systems, periplasmic components [Amino acid transport and metabolism]; Region: ProX; cl17891
365659001406	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
365659001407	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
365659001408	Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]; Region: CzcD; COG1230
365659001409	DNA-binding transcriptional repressor EbgR; Provisional; Region: PRK10339
365659001410	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
365659001411	DNA binding site [nucleotide binding]
365659001412	Ligand-binding domain of DNA transcription repressor GalR which is one of two regulatory proteins involved in galactose transport and metabolism; Region: PBP1_GalR; cd01544
365659001413	putative dimerization interface [polypeptide binding]; other site
365659001414	putative ligand binding site [chemical binding]; other site
365659001415	galactokinase; Provisional; Region: PRK05322
365659001416	Galactokinase galactose-binding signature; Region: GalKase_gal_bdg; pfam10509
365659001417	GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288
365659001418	GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544
365659001419	galactose-1-phosphate uridylyltransferase; Provisional; Region: PRK05270
365659001420	Galactose-1-phosphate uridyl transferase, N-terminal domain; Region: GalP_UDP_transf; pfam01087
365659001421	Galactose-1-phosphate uridyl transferase, C-terminal domain; Region: GalP_UDP_tr_C; pfam02744
365659001422	PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria.  Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443
365659001423	CoenzymeA binding site [chemical binding]; other site
365659001424	subunit interaction site [polypeptide binding]; other site
365659001425	PHB binding site; other site
365659001426	DNA adenine methylase (dam); Region: dam; TIGR00571
365659001427	DNA modification methylase [DNA replication, recombination, and repair]; Region: COG0863
365659001428	DNA methylase; Region: N6_N4_Mtase; pfam01555
365659001429	DpnII restriction endonuclease; Region: DpnII; pfam04556
365659001430	xanthine permease; Region: pbuX; TIGR03173
365659001431	Sulfate transporter family; Region: Sulfate_transp; pfam00916
365659001432	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
365659001433	active site
365659001434	Bleomycin binding protein (BLMA) and similar proteins; BLMA confers bleomycin (Bm) resistance by directly binding to Bm; Region: BLMA_like; cd08349
365659001435	dimer interface [polypeptide binding]; other site
365659001436	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
365659001437	ligand binding site [chemical binding]; other site
365659001438	Human Ape1-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: Ape1-like_AP-endo; cd09087
365659001439	active site
365659001440	putative catalytic site [active]
365659001441	DNA binding site [nucleotide binding]
365659001442	putative phosphate binding site [ion binding]; other site
365659001443	metal binding site A [ion binding]; metal-binding site
365659001444	AP binding site [nucleotide binding]; other site
365659001445	metal binding site B [ion binding]; metal-binding site
365659001446	CAAX protease self-immunity; Region: Abi; pfam02517
365659001447	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
365659001448	dimerization interface [polypeptide binding]; other site
365659001449	putative DNA binding site [nucleotide binding]; other site
365659001450	putative Zn2+ binding site [ion binding]; other site
365659001451	Protein of unknown function (DUF1648); Region: DUF1648; pfam07853
365659001452	SdpI/YhfL protein family; Region: SdpI; pfam13630
365659001453	Protein of unknown function (DUF3290); Region: DUF3290; pfam11694
365659001454	Predicted membrane protein [Function unknown]; Region: COG2323
365659001455	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
365659001456	putative multidrug transporter membrane\ATP-binding components; Provisional; Region: PRK10789
365659001457	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
365659001458	Walker A/P-loop; other site
365659001459	ATP binding site [chemical binding]; other site
365659001460	Q-loop/lid; other site
365659001461	ABC transporter signature motif; other site
365659001462	Walker B; other site
365659001463	D-loop; other site
365659001464	H-loop/switch region; other site
365659001465	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
365659001466	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
365659001467	ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254
365659001468	Walker A/P-loop; other site
365659001469	ATP binding site [chemical binding]; other site
365659001470	Q-loop/lid; other site
365659001471	ABC transporter signature motif; other site
365659001472	Walker B; other site
365659001473	D-loop; other site
365659001474	H-loop/switch region; other site
365659001475	Sugar transferases involved in lipopolysaccharide synthesis [Cell envelope biogenesis, outer membrane]; Region: WcaJ; COG2148
365659001476	Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399
365659001477	3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616
365659001478	inhibitor-cofactor binding pocket; inhibition site
365659001479	pyridoxal 5'-phosphate binding site [chemical binding]; other site
365659001480	catalytic residue [active]
365659001481	anthranilate synthase component I; Provisional; Region: PRK13570
365659001482	Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715
365659001483	chorismate binding enzyme; Region: Chorismate_bind; pfam00425
365659001484	para-aminobenzoate synthase component II; Provisional; Region: PRK08857
365659001485	Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743
365659001486	glutamine binding [chemical binding]; other site
365659001487	catalytic triad [active]
365659001488	anthranilate phosphoribosyltransferase; Provisional; Region: trpD; PRK00188
365659001489	Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885
365659001490	Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591
365659001491	Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331
365659001492	active site
365659001493	ribulose/triose binding site [chemical binding]; other site
365659001494	phosphate binding site [ion binding]; other site
365659001495	substrate (anthranilate) binding pocket [chemical binding]; other site
365659001496	product (indole) binding pocket [chemical binding]; other site
365659001497	Phosphoribosylanthranilate isomerase (PRAI) catalyzes the fourth step of the tryptophan biosynthesis, the conversion of N-(5'- phosphoribosyl)-anthranilate (PRA) to 1-(o-carboxyphenylamino)- 1-deoxyribulose 5-phosphate (CdRP). Most PRAIs are...; Region: PRAI; cd00405
365659001498	active site
365659001499	tryptophan synthase, beta subunit; Region: trpB; TIGR00263
365659001500	Tryptophan synthase-beta:  Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446
365659001501	pyridoxal 5'-phosphate binding site [chemical binding]; other site
365659001502	catalytic residue [active]
365659001503	Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724
365659001504	tryptophan synthase alpha subunit; Provisional; Region: trpA; CHL00200
365659001505	substrate binding site [chemical binding]; other site
365659001506	active site
365659001507	catalytic residues [active]
365659001508	heterodimer interface [polypeptide binding]; other site
365659001509	Type II secretory pathway, prepilin signal peptidase PulO and related peptidases [Cell motility and secretion / Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: PulO; COG1989
365659001510	Bacterial Peptidase A24 N-terminal domain; Region: DiS_P_DiS; pfam06750
365659001511	Type IV leader peptidase family; Region: Peptidase_A24; pfam01478
365659001512	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
365659001513	Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583
365659001514	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1302
365659001515	Small integral membrane protein [Function unknown]; Region: COG5547
365659001516	Predicted membrane protein [Function unknown]; Region: COG2261
365659001517	M protein trans-acting positive regulator (MGA) HTH domain; Region: HTH_Mga; pfam08280
365659001518	Mga helix-turn-helix domain; Region: Mga; pfam05043
365659001519	M protein trans-acting positive regulator (MGA) PRD domain; Region: PRD_Mga; pfam08270
365659001520	Predicted ring-cleavage extradiol dioxygenase [General function prediction only]; Region: COG2514
365659001521	NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604
365659001522	alcohol dehydrogenase and quinone reductase-like medium chain degydrogenases/reductases; Region: MDR_like_2; cd05289
365659001523	putative NAD(P) binding site [chemical binding]; other site
365659001524	Predicted transcriptional regulator [Transcription]; Region: COG1959
365659001525	Transcriptional regulator; Region: Rrf2; pfam02082
365659001526	recombination factor protein RarA; Reviewed; Region: PRK13342
365659001527	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
365659001528	Walker A motif; other site
365659001529	ATP binding site [chemical binding]; other site
365659001530	Walker B motif; other site
365659001531	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189
365659001532	arginine finger; other site
365659001533	MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002
365659001534	Protein of unknown function (DUF3013); Region: DUF3013; pfam11217
365659001535	Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_23; cd04682
365659001536	nudix motif; other site
365659001537	Ribosomal protein L11 methyltransferase (PrmA); Region: PrmA; pfam06325
365659001538	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
365659001539	S-adenosylmethionine binding site [chemical binding]; other site
365659001540	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1385
365659001541	oligoendopeptidase F; Region: pepF; TIGR00181
365659001542	Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins); Region: GluZincin; cl14813
365659001543	Zn binding site [ion binding]; other site
365659001544	Protein of unknown function (DUF2785); Region: DUF2785; pfam10978
365659001545	acetoin reductase; Validated; Region: PRK08643
365659001546	meso-2,3-butanediol dehydrogenase-like, classical (c) SDRs; Region: meso-BDH-like_SDR_c; cd05366
365659001547	NAD binding site [chemical binding]; other site
365659001548	homotetramer interface [polypeptide binding]; other site
365659001549	homodimer interface [polypeptide binding]; other site
365659001550	active site
365659001551	substrate binding site [chemical binding]; other site
365659001552	Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cd00333
365659001553	amphipathic channel; other site
365659001554	Asn-Pro-Ala signature motifs; other site
365659001555	7-cyano-7-deazaguanine reductase; Provisional; Region: PRK13258
365659001556	7-cyano-7-deazaguanosine (preQ0) biosynthesis protein QueE; Region: Bsubt_queE; TIGR03365
365659001557	putative 7-cyano-7-deazaguanosine (preQ0) biosynthesis protein QueE; Region: rSAM_QueE_Ecoli; TIGR04322
365659001558	6-pyruvoyl tetrahydropterin synthase; Region: PTPS; pfam01242
365659001559	active site
365659001560	ExsB is a transcription regulator related protein. It is a subfamily of a Adenosine nucleotide binding superfamily of proteins. This protein family is represented by a single member in nearly every completed large (> 1000 genes) prokaryotic genome. In...; Region: ExsB; cd01995
365659001561	Ligand Binding Site [chemical binding]; other site
365659001562	TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947
365659001563	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
365659001564	catalytic residues [active]
365659001565	MarR family; Region: MarR_2; pfam12802
365659001566	Putative effector of murein hydrolase LrgA [General function prediction only]; Region: COG1380
365659001567	LrgB-like family; Region: LrgB; pfam04172
365659001568	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
365659001569	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
365659001570	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
365659001571	Walker A/P-loop; other site
365659001572	ATP binding site [chemical binding]; other site
365659001573	Q-loop/lid; other site
365659001574	ABC transporter signature motif; other site
365659001575	Walker B; other site
365659001576	D-loop; other site
365659001577	H-loop/switch region; other site
365659001578	ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121
365659001579	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
365659001580	Walker A/P-loop; other site
365659001581	ATP binding site [chemical binding]; other site
365659001582	Q-loop/lid; other site
365659001583	ABC transporter signature motif; other site
365659001584	Walker B; other site
365659001585	D-loop; other site
365659001586	H-loop/switch region; other site
365659001587	Predicted transcriptional regulators [Transcription]; Region: COG1725
365659001588	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
365659001589	DNA-binding site [nucleotide binding]; DNA binding site
365659001590	transcriptional regulator NrdR; Validated; Region: nrdR; PRK00464
365659001591	ATP cone domain; Region: ATP-cone; pfam03477
365659001592	Replication initiation/membrane attachment protein [DNA replication, recombination, and repair]; Region: DnaB; COG3611
365659001593	primosomal protein DnaI; Reviewed; Region: PRK08939
365659001594	Primosomal protein DnaI N-terminus; Region: DnaI_N; pfam07319
365659001595	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
365659001596	Walker A motif; other site
365659001597	ATP binding site [chemical binding]; other site
365659001598	Walker B motif; other site
365659001599	This family contains NADPH-dependent flavin reductase and oxygen-insensitive nitroreductase. These enzymes are homodimeric flavoproteins that contain one FMN per monomer as a cofactor. Flavin reductase catalyzes the reduction of flavin by using NADPH as...; Region: NfsA_FRP; cd02146
365659001600	dimer interface [polypeptide binding]; other site
365659001601	FMN binding site [chemical binding]; other site
365659001602	NADPH bind site [chemical binding]; other site
365659001603	GTP-binding protein Der; Reviewed; Region: PRK00093
365659001604	EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894
365659001605	G1 box; other site
365659001606	GTP/Mg2+ binding site [chemical binding]; other site
365659001607	Switch I region; other site
365659001608	G2 box; other site
365659001609	Switch II region; other site
365659001610	G3 box; other site
365659001611	G4 box; other site
365659001612	G5 box; other site
365659001613	EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895
365659001614	G1 box; other site
365659001615	GTP/Mg2+ binding site [chemical binding]; other site
365659001616	Switch I region; other site
365659001617	G2 box; other site
365659001618	G3 box; other site
365659001619	Switch II region; other site
365659001620	G4 box; other site
365659001621	G5 box; other site
365659001622	protein-export membrane protein SecD; Region: secD; TIGR01129
365659001623	preprotein translocase subunit SecA; Reviewed; Region: PRK12904
365659001624	SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958
365659001625	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
365659001626	nucleotide binding region [chemical binding]; other site
365659001627	ATP-binding site [chemical binding]; other site
365659001628	SEC-C motif; Region: SEC-C; pfam02810
365659001629	3-deoxy-D-arabino-heptulosonate 7-phosphate (DAHP) synthase [Amino acid transport and metabolism]; Region: AroG; COG0722
365659001630	DAHP synthetase I family; Region: DAHP_synth_1; pfam00793
365659001631	3-deoxy-D-arabino-heptulosonate 7-phosphate (DAHP) synthase [Amino acid transport and metabolism]; Region: AroG; COG0722
365659001632	DAHP synthetase I family; Region: DAHP_synth_1; pfam00793
365659001633	4'-phosphopantetheinyl transferase; Provisional; Region: acpS; PRK00070
365659001634	alanine racemase; Reviewed; Region: alr; PRK00053
365659001635	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430
365659001636	active site
365659001637	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
365659001638	dimer interface [polypeptide binding]; other site
365659001639	substrate binding site [chemical binding]; other site
365659001640	catalytic residues [active]
365659001641	ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917
365659001642	RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488
365659001643	ssDNA binding site; other site
365659001644	generic binding surface II; other site
365659001645	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
365659001646	ATP binding site [chemical binding]; other site
365659001647	putative Mg++ binding site [ion binding]; other site
365659001648	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
365659001649	nucleotide binding region [chemical binding]; other site
365659001650	ATP-binding site [chemical binding]; other site
365659001651	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547
365659001652	Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371
365659001653	Transposase; Region: DEDD_Tnp_IS110; pfam01548
365659001654	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547
365659001655	PD-(D/E)XK nuclease family transposase; Region: PDDEXK_2; pfam12784
365659001656	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
365659001657	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
365659001658	Acetyl xylan esterase (AXE1); Region: AXE1; pfam05448
365659001659	V8-like Glu-specific endopeptidase [Amino acid transport and metabolism]; Region: COG3591
365659001660	cleavage site
365659001661	Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad...; Region: Tryp_SPc; cl00149
365659001662	active site
365659001663	Pentraxins are plasma proteins characterized by their pentameric discoid assembly and their Ca2+ dependent ligand binding, such as Serum amyloid P component (SAP) and C-reactive Protein (CRP), which are cytokine-inducible acute-phase proteins implicated...; Region: PTX; cl00102
365659001664	Sialidases or neuraminidases function to bind and hydrolyze terminal sialic acid residues from various glycoconjugates as well as playing roles in pathogenesis, bacterial nutrition and cellular interactions. They have a six-bladed, beta-propeller fold...; Region: Sialidase; cd00260
365659001665	catalytic site [active]
365659001666	Sialidases or neuraminidases function to bind and hydrolyze terminal sialic acid residues from various glycoconjugates as well as playing roles in pathogenesis, bacterial nutrition and cellular interactions. They have a six-bladed, beta-propeller fold...; Region: Sialidase; cd00260
365659001667	Asp-box motif; other site
365659001668	Asp-box motif; other site
365659001669	catalytic site [active]
365659001670	LPXTG-motif cell wall anchor domain; Region: LPXTG_anchor; TIGR01167
365659001671	N-acetylmannosamine-6-phosphate epimerase (NanE) converts N-acetylmannosamine-6-phosphate to N-acetylglucosamine-6-phosphate. This reaction is part of the pathway that allows the usage of sialic acid as a carbohydrate source. Sialic acids are a family of...; Region: NanE; cd04729
365659001672	N-acetylmannosamine-6-phosphate 2-epimerase; Provisional; Region: PRK01130
365659001673	putative active site cavity [active]
365659001674	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
365659001675	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
365659001676	ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209
365659001677	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
365659001678	dimer interface [polypeptide binding]; other site
365659001679	ABC-ATPase subunit interface; other site
365659001680	putative PBP binding loops; other site
365659001681	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
365659001682	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
365659001683	dimer interface [polypeptide binding]; other site
365659001684	conserved gate region; other site
365659001685	putative PBP binding loops; other site
365659001686	ABC-ATPase subunit interface; other site
365659001687	Domain of unknown function (DUF386); Region: DUF386; pfam04074
365659001688	Protein of unknown function, DUF624; Region: DUF624; pfam04854
365659001689	Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329
365659001690	Class I aldolases; Region: Aldolase_Class_I; cl17187
365659001691	catalytic residue [active]
365659001692	Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940
365659001693	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012
365659001694	nucleotide binding site [chemical binding]; other site
365659001695	RelB antitoxin; Region: RelB; cl01171
365659001696	Transcriptional regulators [Transcription]; Region: RpiR; COG1737
365659001697	Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418
365659001698	RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013
365659001699	putative active site [active]
365659001700	Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768
365659001701	Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717
365659001702	Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717
365659001703	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905
365659001704	recombination protein RecR; Reviewed; Region: recR; PRK00076
365659001705	RecR protein; Region: RecR; pfam02132
365659001706	TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR.  RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025
365659001707	putative active site [active]
365659001708	putative metal-binding site [ion binding]; other site
365659001709	tetramer interface [polypeptide binding]; other site
365659001710	D-alanyl-alanine synthetase A; Reviewed; Region: ddl; PRK01966
365659001711	D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820
365659001712	D-ala D-ala ligase C-terminus; Region: Dala_Dala_lig_C; pfam07478
365659001713	UDP-N-acetylmuramyl pentapeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurF; COG0770
365659001714	Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225
365659001715	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
365659001716	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
365659001717	Integral membrane protein (intg_mem_TP0381); Region: Intg_mem_TP0381; pfam09529
365659001718	Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826
365659001719	Helix-turn-helix domain; Region: HTH_38; pfam13936
365659001720	Integrase core domain; Region: rve; pfam00665
365659001721	Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826
365659001722	Helix-turn-helix domain; Region: HTH_38; pfam13936
365659001723	Integrase core domain; Region: rve; pfam00665
365659001724	Cell division ATPase FtsA [Cell division and chromosome partitioning]; Region: ftsA; COG0849
365659001725	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012
365659001726	nucleotide binding site [chemical binding]; other site
365659001727	SHS2 domain inserted in FTSA; Region: SHS2_FTSA; pfam02491
365659001728	Cell division protein FtsA; Region: FtsA; pfam14450
365659001729	Domain of unknown function (DUF3484); Region: DUF3484; pfam11983
365659001730	cell division protein FtsZ; Validated; Region: PRK09330
365659001731	FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes.  FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201
365659001732	nucleotide binding site [chemical binding]; other site
365659001733	SulA interaction site; other site
365659001734	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, YBL036c-like proteins; Region: PLPDE_III_YBL036c_like; cd00635
365659001735	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
365659001736	catalytic residue [active]
365659001737	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1799
365659001738	YGGT family; Region: YGGT; pfam02325
365659001739	Uncharacterized conserved protein, contains S4-like domain [Function unknown]; Region: COG2302
365659001740	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
365659001741	RNA binding surface [nucleotide binding]; other site
365659001742	DivIVA domain; Region: DivI1A_domain; TIGR03544
365659001743	Cell division initiation protein [Cell division and chromosome partitioning]; Region: DivIVA; COG3599
365659001744	The band 7 domain of flotillin (reggie) like proteins. This group contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin.  Many of these band 7 domain-containing proteins are lipid raft-associated.  Individual proteins of this...; Region: Band_7; cl02525
365659001745	isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK05743
365659001746	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
365659001747	active site
365659001748	HIGH motif; other site
365659001749	nucleotide binding site [chemical binding]; other site
365659001750	catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818
365659001751	active site
365659001752	KMSKS motif; other site
365659001753	Anticodon-binding domain of bacterial and eukaryotic mitochondrial isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_BEm; cd07960
365659001754	tRNA binding surface [nucleotide binding]; other site
365659001755	anticodon binding site; other site
365659001756	Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827
365659001757	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
365659001758	catalytic core [active]
365659001759	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
365659001760	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
365659001761	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
365659001762	Walker A/P-loop; other site
365659001763	ATP binding site [chemical binding]; other site
365659001764	Q-loop/lid; other site
365659001765	ABC transporter signature motif; other site
365659001766	Walker B; other site
365659001767	D-loop; other site
365659001768	H-loop/switch region; other site
365659001769	ATP synthase B/B' CF(0); Region: ATP-synt_B; cl17192
365659001770	FtsX-like permease family; Region: FtsX; pfam02687
365659001771	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
365659001772	ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577
365659001773	FtsX-like permease family; Region: FtsX; pfam02687
365659001774	Peroxiredoxin (PRX) family, Atypical 2-cys PRX subfamily; composed of PRXs containing peroxidatic and resolving cysteines, similar to the homodimeric thiol specific antioxidant (TSA) protein also known as TRX-dependent thiol peroxidase (Tpx). Tpx is a...; Region: PRX_Atyp2cys; cd03014
365659001775	dimer interface [polypeptide binding]; other site
365659001776	catalytic triad [active]
365659001777	peroxidatic and resolving cysteines [active]
365659001778	ABC-type metal ion transport system, periplasmic component/surface adhesin [Inorganic ion transport and metabolism]; Region: LraI; COG0803
365659001779	Metal binding protein PsaA.  These proteins have been shown to function as initial receptors in ABC transport of Mn2+ and as surface adhesins in some eubacterial species.  They belong to the TroA superfamily of periplasmic metal binding proteins that...; Region: PsaA; cd01137
365659001780	metal binding site [ion binding]; metal-binding site
365659001781	ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108
365659001782	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
365659001783	ABC-ATPase subunit  interface; other site
365659001784	dimer interface [polypeptide binding]; other site
365659001785	putative PBP binding regions; other site
365659001786	ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121
365659001787	ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235
365659001788	H+ Antiporter protein; Region: 2A0121; TIGR00900
365659001789	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
365659001790	putative substrate translocation pore; other site
365659001791	molybdopterin biosynthesis protein MoeB; Provisional; Region: PRK05690
365659001792	Superfamily of activating enzymes (E1) of the ubiquitin-like proteins. This family includes classical ubiquitin-activating enzymes E1, ubiquitin-like (ubl) activating enzymes and other mechanistic homologes, like MoeB, Thif1 and others. The common...; Region: E1_enzyme_family; cl17196
365659001793	ATP binding site [chemical binding]; other site
365659001794	Predicted metalloendopeptidase [Posttranslational modification, protein turnover, chaperones]; Region: PepO; COG3590
365659001795	Peptidase family M13 includes neprilysin, endothelin-converting enzyme I; Region: M13; cd08662
365659001796	active site
365659001797	Zn binding site [ion binding]; other site
365659001798	Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491
365659001799	Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317
365659001800	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
365659001801	Zn2+ binding site [ion binding]; other site
365659001802	Mg2+ binding site [ion binding]; other site
365659001803	Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399
365659001804	synthetase active site [active]
365659001805	NTP binding site [chemical binding]; other site
365659001806	metal binding site [ion binding]; metal-binding site
365659001807	TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668
365659001808	ACT  domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876
365659001809	D-Tyrosyl-tRNAtyr deacylases; a class of tRNA-dependent hydrolases which are capable of hydrolyzing the ester bond of D-Tyrosyl-tRNA reducing the level of cellular D-Tyrosine while recycling the peptidyl-tRNA; found in bacteria and in eukaryotes but not...; Region: Dtyr_deacylase; cd00563
365659001810	putative active site [active]
365659001811	dimerization interface [polypeptide binding]; other site
365659001812	putative tRNAtyr binding site [nucleotide binding]; other site
365659001813	Mn-dependent transcriptional regulator [Transcription]; Region: TroR; COG1321
365659001814	Iron dependent repressor, N-terminal DNA binding domain; Region: Fe_dep_repress; pfam01325
365659001815	Iron dependent repressor, metal binding and dimerisation domain; Region: Fe_dep_repr_C; pfam02742
365659001816	FeoA domain; Region: FeoA; pfam04023
365659001817	Calcineurin-like phosphoesterase superfamily domain; Region: Metallophos_2; pfam12850
365659001818	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
365659001819	active site
365659001820	metal binding site [ion binding]; metal-binding site
365659001821	Predicted transcriptional regulator [Transcription]; Region: COG1959
365659001822	Transcriptional regulator; Region: Rrf2; pfam02082
365659001823	Lipase.  Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is "interfacial activation", the process of...; Region: Lipase; cd00741
365659001824	nucleophilic elbow; other site
365659001825	catalytic triad; other site
365659001826	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
365659001827	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
365659001828	active site
365659001829	phosphorylation site [posttranslational modification]
365659001830	intermolecular recognition site; other site
365659001831	dimerization interface [polypeptide binding]; other site
365659001832	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
365659001833	DNA binding site [nucleotide binding]
365659001834	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
365659001835	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
365659001836	ATP binding site [chemical binding]; other site
365659001837	Mg2+ binding site [ion binding]; other site
365659001838	G-X-G motif; other site
365659001839	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
365659001840	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
365659001841	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
365659001842	Walker A/P-loop; other site
365659001843	ATP binding site [chemical binding]; other site
365659001844	Q-loop/lid; other site
365659001845	ABC transporter signature motif; other site
365659001846	Walker B; other site
365659001847	D-loop; other site
365659001848	H-loop/switch region; other site
365659001849	Domain of unknown function (DUF389); Region: DUF389; pfam04087
365659001850	threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK00413
365659001851	TGS _ThrRS_N:  ThrRS (threonyl-tRNA Synthetase)  is a class II tRNA synthetase that couples threonine to its cognate tRNA.  In addition to its catalytic and anticodon-binding domains, ThrRS has an N-terminal TGS domain, named after the ThrRS, GTPase, and...; Region: TGS_ThrRS_N; cd01667
365659001852	Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863
365659001853	Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771
365659001854	active site
365659001855	dimer interface [polypeptide binding]; other site
365659001856	motif 1; other site
365659001857	motif 2; other site
365659001858	motif 3; other site
365659001859	ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860
365659001860	anticodon binding site; other site
365659001861	Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353
365659001862	16S/18S rRNA binding site [nucleotide binding]; other site
365659001863	S13e-L30e interaction site [polypeptide binding]; other site
365659001864	25S rRNA binding site [nucleotide binding]; other site
365659001865	iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577
365659001866	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
365659001867	ABC-ATPase subunit  interface; other site
365659001868	dimer interface [polypeptide binding]; other site
365659001869	putative PBP binding regions; other site
365659001870	ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120
365659001871	ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214
365659001872	Walker A/P-loop; other site
365659001873	ATP binding site [chemical binding]; other site
365659001874	Q-loop/lid; other site
365659001875	ABC transporter signature motif; other site
365659001876	Walker B; other site
365659001877	D-loop; other site
365659001878	H-loop/switch region; other site
365659001879	Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+.  Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262
365659001880	Periplasmic binding protein; Region: Peripla_BP_2; pfam01497
365659001881	intersubunit interface [polypeptide binding]; other site
365659001882	Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819
365659001883	1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204
365659001884	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989
365659001885	putative acyl-acceptor binding pocket; other site
365659001886	Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826
365659001887	Helix-turn-helix domain; Region: HTH_38; pfam13936
365659001888	Integrase core domain; Region: rve; pfam00665
365659001889	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474
365659001890	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
365659001891	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
365659001892	motif II; other site
365659001893	Predicted SAM-dependent methyltransferase [General function prediction only]; Region: COG2384
365659001894	Family of unknown function (DUF633); Region: DUF633; pfam04816
365659001895	Uncharacterized conserved protein [Function unknown]; Region: COG0327
365659001896	NIF3 (NGG1p interacting factor 3); Region: NIF3; pfam01784
365659001897	Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665
365659001898	Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665
365659001899	UDP-glucose 4-epimerase; Region: PLN02240
365659001900	UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247
365659001901	NAD binding site [chemical binding]; other site
365659001902	homodimer interface [polypeptide binding]; other site
365659001903	active site
365659001904	substrate binding site [chemical binding]; other site
365659001905	undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714
365659001906	Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187
365659001907	Ligand binding site; other site
365659001908	Putative Catalytic site; other site
365659001909	DXD motif; other site
365659001910	Protein of unknown function (DUF1271); Region: DUF1271; cl01443
365659001911	Ferredoxin [Energy production and conversion]; Region: Fer; COG1141
365659001912	cytidylate kinase; Provisional; Region: cmk; PRK00023
365659001913	Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020
365659001914	CMP-binding site; other site
365659001915	The sites determining sugar specificity; other site
365659001916	Uncharacterized Zn-ribbon-containing protein involved in phosphonate metabolism [Inorganic ion transport and metabolism]; Region: PhnA; COG2824
365659001917	PhnA Zinc-Ribbon; Region: PhnA_Zn_Ribbon; pfam08274
365659001918	PhnA protein; Region: PhnA; pfam03831
365659001919	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
365659001920	Major Facilitator Superfamily; Region: MFS_1; pfam07690
365659001921	putative substrate translocation pore; other site
365659001922	tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021
365659001923	Eukaryotic and bacterial pseudouridine synthases similar to E.  coli TruA; Region: PseudoU_synth_EcTruA; cd02570
365659001924	dimerization interface 3.5A [polypeptide binding]; other site
365659001925	active site
365659001926	4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169
365659001927	dimer interface [polypeptide binding]; other site
365659001928	substrate binding site [chemical binding]; other site
365659001929	ATP binding site [chemical binding]; other site
365659001930	Predicted membrane protein [Function unknown]; Region: COG4720
365659001931	Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006
365659001932	Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321
365659001933	Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092
365659001934	active site
365659001935	Type 1 glutamine amidotransferase (GATase1) domain found in Cobyric Acid Synthase (CobQ); Region: GATase1_CobQ; cd01750
365659001936	catalytic triad [active]
365659001937	UDP-N-acetylmuramyl tripeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurE; COG0769
365659001938	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
365659001939	Domain of unknown function (DUF1727); Region: DUF1727; pfam08353
365659001940	pyridine nucleotide-disulfide oxidoreductase; Provisional; Region: PRK07251
365659001941	ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314
365659001942	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
365659001943	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
365659001944	Ammonia permease [Inorganic ion transport and metabolism]; Region: AmtB; COG0004
365659001945	Nitrogen regulatory protein PII [Amino acid transport and metabolism]; Region: GlnK; COG0347
365659001946	Nitrogen regulatory protein P-II; Region: P-II; smart00938
365659001947	ATP-dependent RNA helicase SrmB; Provisional; Region: PRK11192
365659001948	DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker  B motif; Region: DEADc; cd00268
365659001949	ATP binding site [chemical binding]; other site
365659001950	Mg++ binding site [ion binding]; other site
365659001951	motif III; other site
365659001952	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
365659001953	nucleotide binding region [chemical binding]; other site
365659001954	ATP-binding site [chemical binding]; other site
365659001955	Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826
365659001956	Helix-turn-helix domain; Region: HTH_38; pfam13936
365659001957	Integrase core domain; Region: rve; pfam00665
365659001958	Pleiotropic transcriptional repressor [Transcription]; Region: CodY; COG4465
365659001959	CodY GAF-like domain; Region: CodY; pfam06018
365659001960	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
365659001961	putative DNA binding site [nucleotide binding]; other site
365659001962	putative Zn2+ binding site [ion binding]; other site
365659001963	Isochorismatase family; Region: Isochorismatase; pfam00857
365659001964	Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431
365659001965	catalytic triad [active]
365659001966	conserved cis-peptide bond; other site
365659001967	ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577
365659001968	FtsX-like permease family; Region: FtsX; pfam02687
365659001969	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
365659001970	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
365659001971	Walker A/P-loop; other site
365659001972	ATP binding site [chemical binding]; other site
365659001973	Q-loop/lid; other site
365659001974	ABC transporter signature motif; other site
365659001975	Walker B; other site
365659001976	D-loop; other site
365659001977	H-loop/switch region; other site
365659001978	ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577
365659001979	FtsX-like permease family; Region: FtsX; pfam02687
365659001980	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
365659001981	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
365659001982	active site
365659001983	phosphorylation site [posttranslational modification]
365659001984	intermolecular recognition site; other site
365659001985	dimerization interface [polypeptide binding]; other site
365659001986	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
365659001987	DNA binding site [nucleotide binding]
365659001988	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
365659001989	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
365659001990	dimerization interface [polypeptide binding]; other site
365659001991	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
365659001992	dimer interface [polypeptide binding]; other site
365659001993	phosphorylation site [posttranslational modification]
365659001994	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
365659001995	ATP binding site [chemical binding]; other site
365659001996	Mg2+ binding site [ion binding]; other site
365659001997	G-X-G motif; other site
365659001998	fructose-bisphosphate aldolase; Provisional; Region: PRK09197
365659001999	Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947
365659002000	intersubunit interface [polypeptide binding]; other site
365659002001	active site
365659002002	zinc binding site [ion binding]; other site
365659002003	Na+ binding site [ion binding]; other site
365659002004	RelB antitoxin; Region: RelB; cl01171
365659002005	Plasmid stabilisation system protein; Region: Plasmid_stabil; pfam05016
365659002006	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
365659002007	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
365659002008	catalytic core [active]
365659002009	ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: COG4586
365659002010	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
365659002011	Walker A/P-loop; other site
365659002012	ATP binding site [chemical binding]; other site
365659002013	Q-loop/lid; other site
365659002014	ABC transporter signature motif; other site
365659002015	Walker B; other site
365659002016	D-loop; other site
365659002017	H-loop/switch region; other site
365659002018	ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4587
365659002019	ABC-2 family transporter protein; Region: ABC2_membrane_6; cl01496
365659002020	ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG3694
365659002021	ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4587
365659002022	Peptidase inhibitor I9; Region: Inhibitor_I9; pfam05922
365659002023	Peptidase S8 family domain in Streptococcal C5a peptidases; Region: Peptidases_S8_C5a_Peptidase; cd07475
365659002024	putative active site [active]
365659002025	catalytic triad [active]
365659002026	PA_2: Protease-associated (PA) domain subgroup 2. A subgroup of PA-domain containing proteins. The PA domain is an insert domain in a diverse fraction of proteases. The significance of the PA domain to many of the proteins in which it is inserted is...; Region: PA_2; cd04819
365659002027	PA/protease or protease-like domain interface [polypeptide binding]; other site
365659002028	Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459
365659002029	catalytic residues [active]
365659002030	Fn3-like domain (DUF1034); Region: DUF1034; pfam06280
365659002031	Gram positive anchor; Region: Gram_pos_anchor; pfam00746
365659002032	Protein of unknown function (DUF3397); Region: DUF3397; pfam11877
365659002033	Predicted Fe-S oxidoreductase [General function prediction only]; Region: COG1242
365659002034	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
365659002035	S-adenosylmethionine binding site [chemical binding]; other site
365659002036	NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025
365659002037	NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025
365659002038	Ribonuclease BN family enzyme [Replication, recombination, and repair]; Region: Rbn; COG1295
365659002039	S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Provisional; Region: queA; PRK00147
365659002040	S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Region: queA; TIGR00113
365659002041	6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363
365659002042	GlcN6P_deaminase: Glucosamine-6-phosphate (GlcN6P) deaminase subfamily; GlcN6P deaminase catalyzes the reversible conversion of GlcN6P to D-fructose-6-phosphate (Fru6P) and ammonium. The reaction is an aldo-keto isomerization coupled with an amination or...; Region: GlcN6P_deaminase; cd01399
365659002043	active site
365659002044	trimer interface [polypeptide binding]; other site
365659002045	allosteric site; other site
365659002046	active site lid [active]
365659002047	hexamer (dimer of trimers) interface [polypeptide binding]; other site
365659002048	30S ribosomal protein S21; Reviewed; Region: rpsU; PRK00270
365659002049	HPr kinase/phosphorylase; Provisional; Region: PRK05428
365659002050	HPr Serine kinase N terminus; Region: Hpr_kinase_N; pfam02603
365659002051	HprK/P, the bifunctional histidine-containing protein kinase/phosphatase, controls the phosphorylation state of the phosphocarrier protein HPr and regulates the utilization of carbon sources by gram-positive bacteria. It catalyzes both the ATP-dependent...; Region: HprK_C; cd01918
365659002052	Hpr binding site; other site
365659002053	active site
365659002054	homohexamer subunit interaction site [polypeptide binding]; other site
365659002055	Prolipoprotein diacylglyceryl transferase; Region: LGT; pfam01790
365659002056	Uncharacterized protein containing a divergent version of the methyl-accepting chemotaxis-like domain [General function prediction only]; Region: COG4768
365659002057	YtxH-like protein; Region: YtxH; pfam12732
365659002058	coproporphyrinogen III oxidase; Provisional; Region: PRK08599
365659002059	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
365659002060	FeS/SAM binding site; other site
365659002061	HemN C-terminal domain; Region: HemN_C; pfam06969
365659002062	Acyl-ACP thioesterase [Lipid metabolism]; Region: FatA; COG3884
365659002063	4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586
365659002064	active site
365659002065	4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586
365659002066	active site
365659002067	HAD-superfamily subfamily IIA hydrolase, TIGR01457; Region: HAD-SF-IIA-hyp2
365659002068	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
365659002069	active site
365659002070	motif I; other site
365659002071	motif II; other site
365659002072	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
365659002073	Predicted membrane protein [Function unknown]; Region: COG4478
365659002074	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
365659002075	non-specific DNA binding site [nucleotide binding]; other site
365659002076	salt bridge; other site
365659002077	sequence-specific DNA binding site [nucleotide binding]; other site
365659002078	FOG: Glucan-binding domain (YG repeat) [General function prediction only]; Region: COG5263
365659002079	FOG: Glucan-binding domain (YG repeat) [General function prediction only]; Region: COG5263
365659002080	Arsenate Reductase (ArsC) family, Spx subfamily; Spx is a unique RNA polymerase (RNAP)-binding protein present in bacilli and some mollicutes. It inhibits transcription by binding to the C-terminal domain of the alpha subunit of RNAP, disrupting complex...; Region: ArsC_Spx; cd03032
365659002081	ArsC family; Region: ArsC; pfam03960
365659002082	putative catalytic residues [active]
365659002083	thiol/disulfide switch; other site
365659002084	hypothetical protein; Provisional; Region: PRK04387
365659002085	Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483
365659002086	Inositol-monophosphatase-like domains. This family of phosphatases is dependent on bivalent metal ions such as Mg++, and many members are inhibited by Li+ (which is thought to displace a bivalent ion in the active site). Substrates include fructose-1; Region: IMPase_like; cd01637
365659002087	active site
365659002088	rRNA (cytosine-C(5)-)-methyltransferase RsmF; Reviewed; Region: yebU; PRK11933
365659002089	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
365659002090	S-adenosylmethionine binding site [chemical binding]; other site
365659002091	pre-rRNA processing and ribosome biogenesis; Region: Nol1_Nop2_Fmu_2; pfam13636
365659002092	phosphate binding protein; Region: ptsS_2; TIGR02136
365659002093	Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531
365659002094	ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstC; COG0573
365659002095	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
365659002096	dimer interface [polypeptide binding]; other site
365659002097	conserved gate region; other site
365659002098	putative PBP binding loops; other site
365659002099	ABC-ATPase subunit interface; other site
365659002100	ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstA; COG0581
365659002101	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
365659002102	dimer interface [polypeptide binding]; other site
365659002103	conserved gate region; other site
365659002104	putative PBP binding loops; other site
365659002105	ABC-ATPase subunit interface; other site
365659002106	phosphate transporter ATP-binding protein; Provisional; Region: PRK14237
365659002107	ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260
365659002108	Walker A/P-loop; other site
365659002109	ATP binding site [chemical binding]; other site
365659002110	Q-loop/lid; other site
365659002111	ABC transporter signature motif; other site
365659002112	Walker B; other site
365659002113	D-loop; other site
365659002114	H-loop/switch region; other site
365659002115	phosphate transporter ATP-binding protein; Provisional; Region: PRK14239
365659002116	ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260
365659002117	Walker A/P-loop; other site
365659002118	ATP binding site [chemical binding]; other site
365659002119	Q-loop/lid; other site
365659002120	ABC transporter signature motif; other site
365659002121	Walker B; other site
365659002122	D-loop; other site
365659002123	H-loop/switch region; other site
365659002124	phosphate transport system regulatory protein PhoU; Region: phoU_full; TIGR02135
365659002125	PhoU domain; Region: PhoU; pfam01895
365659002126	PhoU domain; Region: PhoU; pfam01895
365659002127	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
365659002128	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
365659002129	substrate binding pocket [chemical binding]; other site
365659002130	membrane-bound complex binding site; other site
365659002131	hinge residues; other site
365659002132	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167
365659002133	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
365659002134	DNA-binding site [nucleotide binding]; DNA binding site
365659002135	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
365659002136	pyridoxal 5'-phosphate binding site [chemical binding]; other site
365659002137	homodimer interface [polypeptide binding]; other site
365659002138	catalytic residue [active]
365659002139	Alpha-acetolactate decarboxylase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: AlsD; COG3527
365659002140	Predicted membrane protein [Function unknown]; Region: COG4377
365659002141	UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK13905
365659002142	FAD binding domain; Region: FAD_binding_4; pfam01565
365659002143	UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873
365659002144	ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842
365659002145	ATP-binding cassette domain of the polyamine transporter; Region: ABC_PotA_N; cd03300
365659002146	Walker A/P-loop; other site
365659002147	ATP binding site [chemical binding]; other site
365659002148	Q-loop/lid; other site
365659002149	ABC transporter signature motif; other site
365659002150	Walker B; other site
365659002151	D-loop; other site
365659002152	H-loop/switch region; other site
365659002153	TOBE domain; Region: TOBE_2; pfam08402
365659002154	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
365659002155	dimer interface [polypeptide binding]; other site
365659002156	conserved gate region; other site
365659002157	putative PBP binding loops; other site
365659002158	ABC-ATPase subunit interface; other site
365659002159	ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177
365659002160	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
365659002161	dimer interface [polypeptide binding]; other site
365659002162	conserved gate region; other site
365659002163	putative PBP binding loops; other site
365659002164	ABC-ATPase subunit interface; other site
365659002165	Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687
365659002166	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199
365659002167	Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826
365659002168	Helix-turn-helix domain; Region: HTH_38; pfam13936
365659002169	Integrase core domain; Region: rve; pfam00665
365659002170	Uncharacterized conserved protein [Function unknown]; Region: COG4894
365659002171	alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252
365659002172	Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673
365659002173	motif 1; other site
365659002174	active site
365659002175	motif 2; other site
365659002176	motif 3; other site
365659002177	Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863
365659002178	DHHA1 domain; Region: DHHA1; pfam02272
365659002179	cytoplasmic alpha-amylase; Reviewed; Region: PRK09441
365659002180	Alpha amylase catalytic domain found in bacterial and fungal Alpha amylases (also called 1,4-alpha-D-glucan-4-glucanohydrolase); Region: AmyAc_bac_fung_AmyA; cd11318
365659002181	active site
365659002182	Na/Ca binding site [ion binding]; other site
365659002183	catalytic site [active]
365659002184	Domain of unknown function (DUF1939); Region: DUF1939; pfam09154
365659002185	ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555
365659002186	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
365659002187	Walker A/P-loop; other site
365659002188	ATP binding site [chemical binding]; other site
365659002189	Q-loop/lid; other site
365659002190	ABC transporter signature motif; other site
365659002191	Walker B; other site
365659002192	D-loop; other site
365659002193	H-loop/switch region; other site
365659002194	Phosphoglycerol transferase and related proteins, alkaline phosphatase superfamily [Cell envelope biogenesis, outer membrane]; Region: MdoB; COG1368
365659002195	Sulfatase; Region: Sulfatase; pfam00884
365659002196	Predicted SAM-dependent methyltransferases [General function prediction only]; Region: COG1092
365659002197	Middle domain of the SAM-dependent methyltransferase RlmI and related proteins; Region: RlmI_M_like; cd11572
365659002198	putative RNA binding site [nucleotide binding]; other site
365659002199	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
365659002200	3-dehydroquinate dehydratase [Amino acid transport and metabolism]; Region: AroD; COG0710
365659002201	Type I 3-dehydroquinase, (3-dehydroquinate dehydratase or DHQase); Region: DHQase_I; cd00502
365659002202	active site
365659002203	catalytic residue [active]
365659002204	dimer interface [polypeptide binding]; other site
365659002205	shikimate 5-dehydrogenase; Reviewed; Region: aroE; PRK00258
365659002206	Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501
365659002207	NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065
365659002208	shikimate binding site; other site
365659002209	NAD(P) binding site [chemical binding]; other site
365659002210	Glycerol dehydrogenase and related enzymes [Energy production and conversion]; Region: GldA; COG0371
365659002211	Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195
365659002212	active site
365659002213	dimer interface [polypeptide binding]; other site
365659002214	metal binding site [ion binding]; metal-binding site
365659002215	Chorismate synthase [Amino acid transport and metabolism]; Region: AroC; COG0082
365659002216	Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304
365659002217	Tetramer interface [polypeptide binding]; other site
365659002218	active site
365659002219	FMN-binding site [chemical binding]; other site
365659002220	prephenate dehydrogenase; Validated; Region: PRK06545
365659002221	prephenate dehydrogenase; Validated; Region: PRK08507
365659002222	C-terminal ACT domain of the monofunctional, NAD dependent, prephenate dehydrogenase (PDH); Region: ACT_PDH-BS; cd04909
365659002223	hypothetical protein; Provisional; Region: PRK13676
365659002224	LemA family; Region: LemA; cl00742
365659002225	COG1704
365659002226	Repair protein; Region: Repair_PSII; pfam04536
365659002227	3-phosphoshikimate 1-carboxyvinyltransferase; Provisional; Region: PRK02427
365659002228	Enol pyruvate transferases family includes EPSP synthases and UDP-N-acetylglucosamine enolpyruvyl transferase. Both enzymes catalyze the reaction of enolpyruvyl transfer; Region: EPT-like; cd01554
365659002229	hinge; other site
365659002230	active site
365659002231	shikimate kinase; Reviewed; Region: aroK; PRK00131
365659002232	Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464
365659002233	ADP binding site [chemical binding]; other site
365659002234	magnesium binding site [ion binding]; other site
365659002235	putative shikimate binding site; other site
365659002236	prephenate dehydratase; Provisional; Region: PRK11898
365659002237	Prephenate dehydratase; Region: PDT; pfam00800
365659002238	C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905
365659002239	putative L-Phe binding site [chemical binding]; other site
365659002240	Transcriptional regulator [Transcription]; Region: LytR; COG1316
365659002241	LPS biosynthesis protein [Cell envelope biogenesis, outer membrane]; Region: COG3475
365659002242	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
365659002243	This family is most closely related to the GT1 family of glycosyltransferases. WabH in Klebsiella pneumoniae has been shown to transfer a GlcNAc residue from UDP-GlcNAc onto the acceptor GalUA residue in the cellular outer core; Region: GT1_WabH_like; cd03811
365659002244	putative ADP-binding pocket [chemical binding]; other site
365659002245	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
365659002246	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761
365659002247	active site
365659002248	O-antigen polysaccharide polymerase Wzy; Region: O-ag_pol_Wzy; pfam14296
365659002249	adaptor protein; Provisional; Region: PRK02315
365659002250	homoserine dehydrogenase; Provisional; Region: PRK06349
365659002251	Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447
365659002252	Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742
365659002253	ACT_HSDH_Hom CD includes the C-terminal ACT domain of the NAD(P)H-dependent, homoserine dehydrogenase (HSDH) and related domains; Region: ACT_HSDH-Hom; cd04881
365659002254	homoserine kinase; Provisional; Region: PRK01212
365659002255	GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288
365659002256	GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544
365659002257	Peptide methionine sulfoxide reductase [Posttranslational modification, protein turnover, chaperones]; Region: MsrA; COG0225
365659002258	Conserved domain frequently associated with peptide methionine sulfoxide reductase [Posttranslational modification, protein turnover, chaperones]; Region: COG0229
365659002259	SelR domain; Region: SelR; pfam01641
365659002260	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
365659002261	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
365659002262	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
365659002263	Walker A/P-loop; other site
365659002264	ATP binding site [chemical binding]; other site
365659002265	Q-loop/lid; other site
365659002266	ABC transporter signature motif; other site
365659002267	Walker B; other site
365659002268	D-loop; other site
365659002269	H-loop/switch region; other site
365659002270	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
365659002271	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
365659002272	ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254
365659002273	Walker A/P-loop; other site
365659002274	ATP binding site [chemical binding]; other site
365659002275	Q-loop/lid; other site
365659002276	ABC transporter signature motif; other site
365659002277	Walker B; other site
365659002278	D-loop; other site
365659002279	H-loop/switch region; other site
365659002280	TRZ/ATZ family contains enzymes from the atrazine degradation pathway and related hydrolases. Atrazine, a chlorinated herbizide, can be catabolized by a variety of different bacteria. The first three steps of the atrazine dehalogenation pathway are...; Region: ATZ_TRZ_like; cd01298
365659002281	putative substrate binding pocket [chemical binding]; other site
365659002282	active site
365659002283	Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826
365659002284	Helix-turn-helix domain; Region: HTH_38; pfam13936
365659002285	Integrase core domain; Region: rve; pfam00665
365659002286	Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826
365659002287	Helix-turn-helix domain; Region: HTH_38; pfam13936
365659002288	Integrase core domain; Region: rve; pfam00665
365659002289	Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826
365659002290	Helix-turn-helix domain; Region: HTH_38; pfam13936
365659002291	Integrase core domain; Region: rve; pfam00665
365659002292	Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826
365659002293	Helix-turn-helix domain; Region: HTH_38; pfam13936
365659002294	Integrase core domain; Region: rve; pfam00665
365659002295	Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797
365659002296	23S rRNA interface [nucleotide binding]; other site
365659002297	Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site
365659002298	Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387
365659002299	core dimer interface [polypeptide binding]; other site
365659002300	L10 interface [polypeptide binding]; other site
365659002301	L11 interface [polypeptide binding]; other site
365659002302	putative EF-Tu interaction site [polypeptide binding]; other site
365659002303	putative EF-G interaction site [polypeptide binding]; other site
365659002304	Replication initiator protein A (RepA) N-terminus; Region: RepA_N; pfam06970
365659002305	Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315
365659002306	cofactor binding site; other site
365659002307	DNA binding site [nucleotide binding]
365659002308	substrate interaction site [chemical binding]; other site
365659002309	Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315
365659002310	Arsenate reductase and related proteins, glutaredoxin family [Inorganic ion transport and metabolism]; Region: ArsC; COG1393
365659002311	ArsC family; Region: ArsC; pfam03960
365659002312	CAAX protease self-immunity; Region: Abi; pfam02517
365659002313	Transcriptional regulators [Transcription]; Region: RpiR; COG1737
365659002314	Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418
365659002315	RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013
365659002316	putative active site [active]
365659002317	Putative N-acetylmannosamine-6-phosphate epimerase [Carbohydrate transport and metabolism]; Region: NanE; COG3010
365659002318	N-acetylmannosamine-6-phosphate epimerase (NanE) converts N-acetylmannosamine-6-phosphate to N-acetylglucosamine-6-phosphate. This reaction is part of the pathway that allows the usage of sialic acid as a carbohydrate source. Sialic acids are a family of...; Region: NanE; cd04729
365659002319	putative active site cavity [active]
365659002320	Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329
365659002321	N-Acetylneuraminic acid aldolase, also called N-acetylneuraminate lyase (NAL); Region: NAL; cd00954
365659002322	inhibitor site; inhibition site
365659002323	active site
365659002324	dimer interface [polypeptide binding]; other site
365659002325	catalytic residue [active]
365659002326	uncharacterized subgroup of the Na(+)/iodide (NIS) cotransporter subfamily; putative solute-binding domain; Region: SLC5sbd_NIS-like_u3; cd11495
365659002327	Na binding site [ion binding]; other site
365659002328	Domain of unknown function (DUF386); Region: DUF386; pfam04074
365659002329	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
365659002330	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
365659002331	Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894
365659002332	Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940
365659002333	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012
365659002334	V-type ATP synthase subunit I; Validated; Region: PRK05771
365659002335	V-type ATP synthase subunit K; Validated; Region: PRK06558
365659002336	ATP synthase subunit C; Region: ATP-synt_C; pfam00137
365659002337	ATP synthase subunit C; Region: ATP-synt_C; pfam00137
365659002338	Archaeal/vacuolar-type H+-ATPase subunit E [Energy production and conversion]; Region: NtpE; COG1390
365659002339	Archaeal/vacuolar-type H+-ATPase subunit C [Energy production and conversion]; Region: NtpC; COG1527
365659002340	V-type ATP synthase subunit C; Provisional; Region: PRK01198; cl00660
365659002341	V-type ATP synthase subunit F; Provisional; Region: PRK01395
365659002342	V-type ATP synthase subunit A; Provisional; Region: PRK04192
365659002343	ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874
365659002344	V/A-type ATP synthase catalytic subunit A. These ATPases couple ATP hydrolysis to the build up of a H+ gradient, but V-type ATPases do not catalyze the reverse reaction.  The Vacuolar (V-type) ATPase is found in the membranes of vacuoles, the golgi...; Region: V_A-ATPase_A; cd01134
365659002345	Walker A motif/ATP binding site; other site
365659002346	Walker B motif; other site
365659002347	ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306
365659002348	V-type ATP synthase subunit B; Provisional; Region: PRK04196
365659002349	ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874
365659002350	V/A-type ATP synthase (non-catalytic) subunit B. These ATPases couple ATP hydrolysis to the build up of a H+ gradient, but V-type ATPases do not catalyze the reverse reaction. The Vacuolar (V-type) ATPase is found in the membranes of vacuoles, the golgi...; Region: V_A-ATPase_B; cd01135
365659002351	Walker A motif homologous position; other site
365659002352	Walker B motif; other site
365659002353	ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306
365659002354	V-type ATP synthase subunit D; Reviewed; Region: PRK00373
365659002355	Transposase IS200 like; Region: Y1_Tnp; pfam01797
365659002356	YSIRK type signal peptide; Region: YSIRK_signal; pfam04650
365659002357	Domain of Unknown Function (DUF1542); Region: DUF1542; pfam07564
365659002358	Domain of Unknown Function (DUF1542); Region: DUF1542; pfam07564
365659002359	Transposase IS200 like; Region: Y1_Tnp; pfam01797
365659002360	Transposase IS200 like; Region: Y1_Tnp; pfam01797
365659002361	glutamate dehydrogenase; Provisional; Region: PRK09414
365659002362	Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812
365659002363	NAD(P) binding domain of glutamate dehydrogenase, subgroup 2; Region: NAD_bind_2_Glu_DH; cd05313
365659002364	NAD(P) binding site [chemical binding]; other site
365659002365	dihydroorotate dehydrogenase (subfamily 1) family protein; Region: pyrD_sub1_fam; TIGR01037
365659002366	Dihydroorotate dehydrogenase (DHOD) class 1A FMN-binding domain. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine...; Region: DHOD_1A_like; cd04741
365659002367	active site
365659002368	FMN binding site [chemical binding]; other site
365659002369	substrate binding site [chemical binding]; other site
365659002370	catalytic residues [active]
365659002371	homodimer interface [polypeptide binding]; other site
365659002372	DNA polymerase III subunit delta; Reviewed; Region: holA; PRK05574
365659002373	DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144
365659002374	Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605
365659002375	Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081
365659002376	Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777
365659002377	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4470
365659002378	ribosomal RNA large subunit methyltransferase N; Provisional; Region: PRK14455
365659002379	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
365659002380	FeS/SAM binding site; other site
365659002381	Glycopeptide antibiotics resistance protein [Defense mechanisms]; Region: VanZ; COG4767
365659002382	ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488
365659002383	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
365659002384	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
365659002385	ABC transporter; Region: ABC_tran_2; pfam12848
365659002386	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
365659002387	Peptidyl-prolyl cis-trans isomerase (rotamase) - cyclophilin family [Posttranslational modification, protein turnover, chaperones]; Region: PpiB; COG0652
365659002388	active site
365659002389	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
365659002390	non-specific DNA binding site [nucleotide binding]; other site
365659002391	salt bridge; other site
365659002392	sequence-specific DNA binding site [nucleotide binding]; other site
365659002393	Protein of unknown function (DUF3796); Region: DUF3796; pfam12676
365659002394	Ribosomal protein S16 [Translation, ribosomal structure and biogenesis]; Region: RpsP; COG0228
365659002395	Predicted RNA-binding protein (contains KH domain) [General function prediction only]; Region: COG1837
365659002396	KH domain; Region: KH_4; pfam13083
365659002397	G-X-X-G motif; other site
365659002398	Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain superfamily; Region: NTP-PPase; cl16941
365659002399	metal binding site [ion binding]; metal-binding site
365659002400	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
365659002401	16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK00122
365659002402	RimM N-terminal domain; Region: RimM; pfam01782
365659002403	PRC-barrel domain; Region: PRC; pfam05239
365659002404	tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026
365659002405	ATP cone domain; Region: ATP-cone; pfam03477
365659002406	Uncharacterized protein conserved in bacteria (DUF2128); Region: DUF2128; cl01839
365659002407	Uncharacterized conserved protein [General function prediction only]; Region: BioY; COG1268
365659002408	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
365659002409	putative bacteriocin export ABC transporter, lactococcin 972 group; Region: L_ocin_972_ABC; TIGR03608
365659002410	Walker A/P-loop; other site
365659002411	ATP binding site [chemical binding]; other site
365659002412	Q-loop/lid; other site
365659002413	ABC transporter signature motif; other site
365659002414	Walker B; other site
365659002415	D-loop; other site
365659002416	H-loop/switch region; other site
365659002417	glutathione reductase; Validated; Region: PRK06116
365659002418	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
365659002419	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
365659002420	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
365659002421	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
365659002422	HlyD family secretion protein; Region: HlyD_3; pfam13437
365659002423	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
365659002424	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
365659002425	Walker A/P-loop; other site
365659002426	ATP binding site [chemical binding]; other site
365659002427	Q-loop/lid; other site
365659002428	ABC transporter signature motif; other site
365659002429	Walker B; other site
365659002430	D-loop; other site
365659002431	H-loop/switch region; other site
365659002432	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
365659002433	ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577
365659002434	FtsX-like permease family; Region: FtsX; pfam02687
365659002435	methionyl-tRNA synthetase; Reviewed; Region: PRK12267
365659002436	catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814
365659002437	active site
365659002438	HIGH motif; other site
365659002439	KMSKS motif; other site
365659002440	Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957
365659002441	tRNA binding surface [nucleotide binding]; other site
365659002442	anticodon binding site; other site
365659002443	tRNA-binding-domain-containing Escherichia coli methionyl-tRNA synthetase (EcMetRS)-like proteins.  This family includes EcMetRS and Aquifex aeolicus Trbp111 (AaTrbp111). This domain has general tRNA binding properties.  MetRS aminoacylates methionine...; Region: tRNA_bind_EcMetRS_like; cd02800
365659002444	dimer interface [polypeptide binding]; other site
365659002445	putative tRNA-binding site [nucleotide binding]; other site
365659002446	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
365659002447	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
365659002448	active site
365659002449	catalytic tetrad [active]
365659002450	Protein of unknown function (DUF2829); Region: DUF2829; pfam11195
365659002451	3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK06550
365659002452	classical (c) SDRs; Region: SDR_c; cd05233
365659002453	NAD(P) binding site [chemical binding]; other site
365659002454	active site
365659002455	Contains a crystal structure of the Nudix hydrolase from Enterococcus faecalis, which has an unknown function. In general, members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes...; Region: Nudix_Hydrolase_25; cd04684
365659002456	nudix motif; other site
365659002457	GNAT acetyltransferase; Region: GNAT_acetyltran; pfam12746
365659002458	CYTH-like (also known as triphosphate tunnel metalloenzyme (TTM)-like) Phosphatases; Region: CYTH-like_Pase; cl11964
365659002459	putative active site; other site
365659002460	putative metal binding residues [ion binding]; other site
365659002461	signature motif; other site
365659002462	putative triphosphate binding site [ion binding]; other site
365659002463	ASC-1 homology or ASCH domain, a small beta-barrel domain found in all three kingdoms of life. ASCH resembles the RNA-binding PUA domain and may also interact with RNA. ASCH has been proposed to function as an RNA-binding domain during coactivation; Region: ASCH; cl01020
365659002464	Aminopeptidase N [Amino acid transport and metabolism]; Region: PepN; COG0308
365659002465	Peptidase M1 Aminopeptidase N family incudes tricorn interacting factor F3, Endoplasmic reticulum aminopeptidase 1 (ERAP1), Aminopeptidase Q (APQ); Region: M1_APN_2; cd09601
365659002466	Zn binding site [ion binding]; other site
365659002467	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
365659002468	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
365659002469	active site
365659002470	phosphorylation site [posttranslational modification]
365659002471	intermolecular recognition site; other site
365659002472	dimerization interface [polypeptide binding]; other site
365659002473	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
365659002474	DNA binding site [nucleotide binding]
365659002475	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
365659002476	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
365659002477	dimer interface [polypeptide binding]; other site
365659002478	phosphorylation site [posttranslational modification]
365659002479	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
365659002480	ATP binding site [chemical binding]; other site
365659002481	Mg2+ binding site [ion binding]; other site
365659002482	G-X-G motif; other site
365659002483	Protein of unknown function (DUF3270); Region: DUF3270; pfam11674
365659002484	Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826
365659002485	Peptidase family U32; Region: Peptidase_U32; pfam01136
365659002486	bifunctional ATP-dependent DNA helicase/DNA polymerase III subunit epsilon; Validated; Region: PRK07246
365659002487	DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127
365659002488	active site
365659002489	catalytic site [active]
365659002490	substrate binding site [chemical binding]; other site
365659002491	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
365659002492	ATP binding site [chemical binding]; other site
365659002493	Helicase C-terminal domain; Region: Helicase_C_2; pfam13307
365659002494	Bacterial cell division membrane protein [Cell division and chromosome partitioning]; Region: FtsW; COG0772
365659002495	DJ-1 family protein; Region: not_thiJ; TIGR01383
365659002496	Type 1 glutamine amidotransferase (GATase1)-like domain found in Human DJ-1; Region: GATase1_DJ-1; cd03135
365659002497	conserved cys residue [active]
365659002498	Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826
365659002499	Helix-turn-helix domain; Region: HTH_38; pfam13936
365659002500	Integrase core domain; Region: rve; pfam00665
365659002501	Haloacid dehalogenase-like hydrolase; Region: HAD_2; pfam13419
365659002502	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
365659002503	motif II; other site
365659002504	DNA gyrase subunit B; Validated; Region: gyrB; PRK05644
365659002505	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
365659002506	Mg2+ binding site [ion binding]; other site
365659002507	G-X-G motif; other site
365659002508	TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822
365659002509	anchoring element; other site
365659002510	dimer interface [polypeptide binding]; other site
365659002511	ATP binding site [chemical binding]; other site
365659002512	TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366
365659002513	active site
365659002514	putative metal-binding site [ion binding]; other site
365659002515	DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986
365659002516	Negative regulator of septation ring formation [Cell division and chromosome partitioning]; Region: EzrA; COG4477
365659002517	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
365659002518	Domain of unknown function (DUF1827); Region: DUF1827; pfam08860
365659002519	Contains a crystal structure of the Nudix hydrolase from Enterococcus faecalis, which has an unknown function. In general, members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes...; Region: Nudix_Hydrolase_25; cd04684
365659002520	nudix motif; other site
365659002521	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
365659002522	ATPases associated with a variety of cellular activities; Region: AAA; smart00382
365659002523	Walker A motif; other site
365659002524	ATP binding site [chemical binding]; other site
365659002525	Walker B motif; other site
365659002526	arginine finger; other site
365659002527	UvrB/uvrC motif; Region: UVR; pfam02151
365659002528	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
365659002529	Walker A motif; other site
365659002530	ATP binding site [chemical binding]; other site
365659002531	Walker B motif; other site
365659002532	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431
365659002533	Protein of unknown function (DUF1797); Region: DUF1797; cl11550
365659002534	ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215
365659002535	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
365659002536	dimer interface [polypeptide binding]; other site
365659002537	conserved gate region; other site
365659002538	putative PBP binding loops; other site
365659002539	ABC-ATPase subunit interface; other site
365659002540	ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126
365659002541	ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262
365659002542	Walker A/P-loop; other site
365659002543	ATP binding site [chemical binding]; other site
365659002544	Q-loop/lid; other site
365659002545	ABC transporter signature motif; other site
365659002546	Walker B; other site
365659002547	D-loop; other site
365659002548	H-loop/switch region; other site
365659002549	bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK14179
365659002550	Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763
365659002551	NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080
365659002552	homodimer interface [polypeptide binding]; other site
365659002553	NADP binding site [chemical binding]; other site
365659002554	substrate binding site [chemical binding]; other site
365659002555	B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171
365659002556	putative substrate binding site [chemical binding]; other site
365659002557	putative ATP binding site [chemical binding]; other site
365659002558	RPI_A: Ribose 5-phosphate isomerase type A (RPI_A) subfamily; RPI catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate, the first step of the non-oxidative branch of the pentose phosphate pathway. This reaction leads to the...; Region: RPI_A; cd01398
365659002559	tetramer (dimer of dimers) interface [polypeptide binding]; other site
365659002560	active site
365659002561	dimer interface [polypeptide binding]; other site
365659002562	phosphopentomutase; Provisional; Region: PRK05362
365659002563	Metalloenzyme superfamily; Region: Metalloenzyme; pfam01676
365659002564	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3797
365659002565	purine nucleoside phosphorylase; Provisional; Region: PRK08202
365659002566	Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038
365659002567	Putative ClC chloride channel.  Clc proteins are putative halogen ion (Cl-, Br- and I-) transporters found in eubacteria. They belong to the ClC superfamily of halogen ion channels, which share a unique double-barreled architecture and voltage-dependent...; Region: ClC_like; cd01033
365659002568	putative ion selectivity filter; other site
365659002569	putative pore gating glutamate residue; other site
365659002570	GMP synthase - Glutamine amidotransferase domain [Nucleotide transport and metabolism]; Region: GuaA; COG0518
365659002571	Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_1; cd01741
365659002572	catalytic triad [active]
365659002573	purine nucleoside phosphorylase; Reviewed; Region: deoD; PRK05819
365659002574	NAD-dependent deacetylase; Provisional; Region: PRK00481
365659002575	SIR2 superfamily of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+; Region: SIR2; cl00195
365659002576	topology modulation protein; Provisional; Region: PRK07261
365659002577	Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cd02019
365659002578	active site
365659002579	30S ribosomal protein S20; Reviewed; Region: rpsT; PRK00239
365659002580	pantothenate kinase; Provisional; Region: PRK05439
365659002581	Pantothenate kinase (PanK) catalyzes the phosphorylation of pantothenic acid to form 4'-phosphopantothenic, which is the first of five steps in coenzyme A (CoA) biosynthetic pathway. The reaction carried out by this enzyme is a key regulatory point...; Region: PanK; cd02025
365659002582	ATP-binding site [chemical binding]; other site
365659002583	CoA-binding site [chemical binding]; other site
365659002584	Mg2+-binding site [ion binding]; other site
365659002585	Helix-Turn-Helix DNA binding domain of the MerR1 transcription regulator; Region: HTH_MerR1; cd04783
365659002586	Hg(II)-responsive transcriptional regulator; Region: MerR; TIGR02051
365659002587	DNA binding residues [nucleotide binding]
365659002588	dimer interface [polypeptide binding]; other site
365659002589	mercury binding site [ion binding]; other site
365659002590	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371
365659002591	metal-binding site [ion binding]
365659002592	mercuric reductase; Region: MerA; TIGR02053
365659002593	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
365659002594	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
365659002595	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
365659002596	pfam01610, ISL3 family
365659002597	16S RNA G1207 methylase RsmC [Translation, ribosomal structure and biogenesis]; Region: RsmC; COG2813
365659002598	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
365659002599	S-adenosylmethionine binding site [chemical binding]; other site
365659002600	pyrimidine-nucleoside phosphorylase; Reviewed; Region: PRK06078
365659002601	Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885
365659002602	Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591
365659002603	Pyrimidine nucleoside phosphorylase C-terminal domain; Region: PYNP_C; pfam07831
365659002604	2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family; Region: DeoC; cd00959
365659002605	intersubunit interface [polypeptide binding]; other site
365659002606	active site
365659002607	catalytic residue [active]
365659002608	Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283
365659002609	active site
365659002610	catalytic motif [active]
365659002611	Zn binding site [ion binding]; other site
365659002612	Uncharacterized ABC-type transport system, periplasmic component/surface lipoprotein [General function prediction only]; Region: Med; COG1744
365659002613	Periplasmic binding domain of basic membrane lipoprotein, PnrA, in Treponema pallidum and its homologs from other bacteria and Archaea; Region: PBP1_BmpA_PnrA_like; cd06354
365659002614	ligand binding site [chemical binding]; other site
365659002615	ABC-type uncharacterized transport systems, ATPase components [General function prediction only]; Region: COG3845
365659002616	First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216
365659002617	Walker A/P-loop; other site
365659002618	ATP binding site [chemical binding]; other site
365659002619	Q-loop/lid; other site
365659002620	ABC transporter signature motif; other site
365659002621	Walker B; other site
365659002622	D-loop; other site
365659002623	H-loop/switch region; other site
365659002624	Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215
365659002625	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
365659002626	Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580
365659002627	TM-ABC transporter signature motif; other site
365659002628	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
365659002629	Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580
365659002630	TM-ABC transporter signature motif; other site
365659002631	putative glycerol-3-phosphate acyltransferase PlsY; Provisional; Region: PRK00220
365659002632	DNA topoisomerase IV, B subunit, Gram-positive; Region: parE_Gpos; TIGR01058
365659002633	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
365659002634	Mg2+ binding site [ion binding]; other site
365659002635	G-X-G motif; other site
365659002636	TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822
365659002637	anchoring element; other site
365659002638	dimer interface [polypeptide binding]; other site
365659002639	ATP binding site [chemical binding]; other site
365659002640	TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366
365659002641	active site
365659002642	putative metal-binding site [ion binding]; other site
365659002643	DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986
365659002644	Uncharacterized conserved protein [Function unknown]; Region: COG1479
365659002645	Protein of unknown function DUF262; Region: DUF262; pfam03235
365659002646	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
365659002647	Coenzyme A binding pocket [chemical binding]; other site
365659002648	pfam04439, Adenyl_transf, streptomycin adenylyltransferase
365659002649	DNA topoisomerase IV, A subunit, Gram-positive; Region: parC_Gpos; TIGR01061
365659002650	DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187
365659002651	CAP-like domain; other site
365659002652	active site
365659002653	primary dimer interface [polypeptide binding]; other site
365659002654	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
365659002655	branched-chain amino acid aminotransferase; Provisional; Region: PRK13357
365659002656	BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids  leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557
365659002657	homodimer interface [polypeptide binding]; other site
365659002658	substrate-cofactor binding pocket; other site
365659002659	catalytic residue [active]
365659002660	ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166
365659002661	The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504
365659002662	peptide binding site [polypeptide binding]; other site
365659002663	Protein of unknown function (DUF2969); Region: DUF2969; pfam11184
365659002664	30S ribosomal protein S1; Reviewed; Region: rpsA; PRK06676
365659002665	S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687
365659002666	RNA binding site [nucleotide binding]; other site
365659002667	S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465
365659002668	RNA binding site [nucleotide binding]; other site
365659002669	S1_RPS1_repeat_ec3: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec3; cd05688
365659002670	RNA binding site [nucleotide binding]; other site
365659002671	S1_RPS1_repeat_hs4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_hs4; cd05692
365659002672	RNA binding site [nucleotide binding]; other site
365659002673	GAF domain-containing protein [Signal transduction mechanisms]; Region: COG1956
365659002674	GAF domain; Region: GAF_2; pfam13185
365659002675	DNA polymerase III subunits gamma and tau; Validated; Region: PRK05563
365659002676	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
365659002677	Walker A motif; other site
365659002678	ATP binding site [chemical binding]; other site
365659002679	Walker B motif; other site
365659002680	arginine finger; other site
365659002681	DNA polymerase III subunits gamma and tau domain III; Region: DNA_pol3_gamma3; pfam12169
365659002682	Protein of unknown function (DUF3272); Region: DUF3272; pfam11676
365659002683	Cysteine desulfurase activator ATPase [Posttranslational modification, protein turnover, chaperones]; Region: sufC; COG0396
365659002684	ABC-type transport system involved in Fe-S cluster assembly, ATPase component; Region: ABC_FeS_Assembly; cd03217
365659002685	Walker A/P-loop; other site
365659002686	ATP binding site [chemical binding]; other site
365659002687	Q-loop/lid; other site
365659002688	ABC transporter signature motif; other site
365659002689	Walker B; other site
365659002690	D-loop; other site
365659002691	H-loop/switch region; other site
365659002692	Cysteine desulfurase activator SufB [Posttranslational modification, protein turnover, chaperones]; Region: SufB; COG0719
365659002693	FeS assembly protein SufD; Region: sufD; TIGR01981
365659002694	Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520
365659002695	Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453
365659002696	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
365659002697	catalytic residue [active]
365659002698	NifU homolog involved in Fe-S cluster formation [Energy production and conversion]; Region: IscU; COG0822
365659002699	Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664
365659002700	trimerization site [polypeptide binding]; other site
365659002701	active site
365659002702	cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814; cl03223
365659002703	FeS assembly protein SufB; Region: sufB; TIGR01980
365659002704	D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: DacC; COG1686
365659002705	Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872
365659002706	Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; smart00936
365659002707	Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628
365659002708	Domain of unknown function DUF20; Region: UPF0118; pfam01594
365659002709	elongation factor Tu; Reviewed; Region: PRK00049
365659002710	Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884
365659002711	G1 box; other site
365659002712	GEF interaction site [polypeptide binding]; other site
365659002713	GTP/Mg2+ binding site [chemical binding]; other site
365659002714	Switch I region; other site
365659002715	G2 box; other site
365659002716	G3 box; other site
365659002717	Switch II region; other site
365659002718	G4 box; other site
365659002719	G5 box; other site
365659002720	EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697
365659002721	Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707
365659002722	Antibiotic Binding Site [chemical binding]; other site
365659002723	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251
365659002724	DEAD-like helicases superfamily; Region: DEXDc; smart00487
365659002725	ATP binding site [chemical binding]; other site
365659002726	putative Mg++ binding site [ion binding]; other site
365659002727	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
365659002728	nucleotide binding region [chemical binding]; other site
365659002729	ATP-binding site [chemical binding]; other site
365659002730	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
365659002731	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
365659002732	Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826
365659002733	Helix-turn-helix domain; Region: HTH_38; pfam13936
365659002734	Integrase core domain; Region: rve; pfam00665
365659002735	50S ribosomal protein L21; Validated; Region: rplU; PRK05573
365659002736	Predicted ribosomal protein [Translation, ribosomal structure and biogenesis]; Region: COG2868
365659002737	50S ribosomal protein L27; Validated; Region: rpmA; PRK05435
365659002738	Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826
365659002739	Helix-turn-helix domain; Region: HTH_38; pfam13936
365659002740	Integrase core domain; Region: rve; pfam00665
365659002741	Transcriptional regulator [Transcription]; Region: LysR; COG0583
365659002742	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
365659002743	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
365659002744	dimerization interface [polypeptide binding]; other site
365659002745	lipoprotein signal peptidase; Provisional; Region: PRK14797
365659002746	Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564
365659002747	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
365659002748	RNA binding surface [nucleotide binding]; other site
365659002749	Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869
365659002750	active site
365659002751	Predicted hydrolase (metallo-beta-lactamase superfamily) [General function prediction only]; Region: ComEC; COG2333
365659002752	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
365659002753	Predicted hydrolase (metallo-beta-lactamase superfamily) [General function prediction only]; Region: ComEC; COG2333
365659002754	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
365659002755	FOG: Glucan-binding domain (YG repeat) [General function prediction only]; Region: COG5263
365659002756	Glutamate 5-kinase [Amino acid transport and metabolism]; Region: ProB; COG0263
365659002757	AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242
365659002758	nucleotide binding site [chemical binding]; other site
365659002759	homotetrameric interface [polypeptide binding]; other site
365659002760	putative phosphate binding site [ion binding]; other site
365659002761	putative allosteric binding site; other site
365659002762	PUA domain; Region: PUA; pfam01472
365659002763	Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079
365659002764	gamma-glutamyl phosphate reductase; Region: proA; TIGR00407
365659002765	putative catalytic cysteine [active]
365659002766	pyrroline-5-carboxylate reductase; Region: PLN02688
365659002767	Pyrroline-5-carboxylate reductase [Amino acid transport and metabolism]; Region: ProC; COG0345
365659002768	thymidylate kinase; Validated; Region: tmk; PRK00698
365659002769	Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672
365659002770	TMP-binding site; other site
365659002771	ATP-binding site [chemical binding]; other site
365659002772	DNA polymerase III subunit delta'; Validated; Region: PRK07276
365659002773	DNA polymerase III subunit delta'; Validated; Region: PRK08485
365659002774	DNA replication intiation control protein YabA; Reviewed; Region: PRK13169
365659002775	Predicted methyltransferases [General function prediction only]; Region: COG0313
365659002776	Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648
365659002777	putative SAM binding site [chemical binding]; other site
365659002778	putative homodimer interface [polypeptide binding]; other site
365659002779	Site-specific DNA methylase [DNA replication, recombination, and repair]; Region: Dcm; COG0270
365659002780	Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315
365659002781	cofactor binding site; other site
365659002782	DNA binding site [nucleotide binding]
365659002783	substrate interaction site [chemical binding]; other site
365659002784	Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315
365659002785	Restriction endonuclease BpuJI - N terminal; Region: BpuJI_N; pfam11564
365659002786	Domain of unknown function (DUF3883); Region: DUF3883; pfam13020
365659002787	Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315
365659002788	DNA-methyltransferase (dcm); Region: dcm; TIGR00675
365659002789	cofactor binding site; other site
365659002790	DNA binding site [nucleotide binding]
365659002791	substrate interaction site [chemical binding]; other site
365659002792	Abortive infection C-terminus; Region: Abi_C; pfam14355
365659002793	Protein of unknown function (DUF4231); Region: DUF4231; pfam14015
365659002794	Nucleotidyltransferase (NT) domain of 2'5'-oligoadenylate (2-5A)synthetase (2-5OAS) and class I CCA-adding enzyme; Region: NT_2-5OAS_ClassI-CCAase; cd05400
365659002795	active site
365659002796	NTP binding site [chemical binding]; other site
365659002797	metal binding triad [ion binding]; metal-binding site
365659002798	tRNA (uracil-5-)-methyltransferase Gid; Reviewed; Region: PRK05335
365659002799	Glucose inhibited division protein A; Region: GIDA; pfam01134
365659002800	UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254
365659002801	putative nucleotide binding site [chemical binding]; other site
365659002802	uridine monophosphate binding site [chemical binding]; other site
365659002803	homohexameric interface [polypeptide binding]; other site
365659002804	ribosome recycling factor; Reviewed; Region: frr; PRK00083
365659002805	Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation.  Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520
365659002806	hinge region; other site
365659002807	Predicted RNA-bindining protein (contains S1 and HTH domains) [General function prediction only]; Region: COG2996
365659002808	S1 domain; Region: S1_2; pfam13509
365659002809	S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927
365659002810	hypothetical protein; Provisional; Region: PRK13672
365659002811	Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702
365659002812	PhoH-like protein; Region: PhoH; pfam02562
365659002813	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
365659002814	Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583
365659002815	SLBB domain; Region: SLBB; pfam10531
365659002816	comEA protein; Region: comE; TIGR01259
365659002817	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cl14786
365659002818	Predicted membrane metal-binding protein [General function prediction only]; Region: ComEC; COG0658
365659002819	Domain of unknown function (DUF4131); Region: DUF4131; pfam13567
365659002820	Competence protein; Region: Competence; pfam03772
365659002821	Predicted hydrolase (metallo-beta-lactamase superfamily) [General function prediction only]; Region: ComEC; COG2333
365659002822	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
365659002823	cytochrome c biogenesis protein CcmA; Provisional; Region: PRK13541
365659002824	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
365659002825	Walker A/P-loop; other site
365659002826	ATP binding site [chemical binding]; other site
365659002827	Q-loop/lid; other site
365659002828	ABC transporter signature motif; other site
365659002829	Walker B; other site
365659002830	D-loop; other site
365659002831	H-loop/switch region; other site
365659002832	translation initiation factor IF-3; Reviewed; Region: infC; PRK00028
365659002833	Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198
365659002834	Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707
365659002835	50S ribosomal protein L35; Reviewed; Region: rpmI; PRK00172
365659002836	Ribosomal protein L20; Region: Ribosomal_L20; cd07026
365659002837	23S rRNA binding site [nucleotide binding]; other site
365659002838	L21 binding site [polypeptide binding]; other site
365659002839	L13 binding site [polypeptide binding]; other site
365659002840	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
365659002841	Glyoxalase I catalyzes the isomerization of the hemithioacetal, formed by a 2-oxoaldehyde and glutathione, to S-D-lactoylglutathione; Region: Glyoxalase_I; cd07233
365659002842	dimer interface [polypeptide binding]; other site
365659002843	active site
365659002844	metal binding site [ion binding]; metal-binding site
365659002845	glutathione binding site [chemical binding]; other site
365659002846	Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826
365659002847	Helix-turn-helix domain; Region: HTH_38; pfam13936
365659002848	Integrase core domain; Region: rve; pfam00665
365659002849	dihydroorotate dehydrogenase electron transfer subunit; Reviewed; Region: PRK00054
365659002850	FAD/NAD binding domain in the electron transfer subunit of dihydroorotate dehydrogenase. Dihydroorotate dehydrogenases (DHODs) catalyze the only redox reaction in pyrimidine de novo biosynthesis. They catalyze the oxidation of (S)-dihydroorotate to...; Region: DHOD_e_trans; cd06218
365659002851	FAD binding pocket [chemical binding]; other site
365659002852	FAD binding motif [chemical binding]; other site
365659002853	phosphate binding motif [ion binding]; other site
365659002854	beta-alpha-beta structure motif; other site
365659002855	NAD binding pocket [chemical binding]; other site
365659002856	Iron coordination center [ion binding]; other site
365659002857	dihydroorotate dehydrogenase (subfamily 1) family protein; Region: pyrD_sub1_fam; TIGR01037
365659002858	Dihydroorotate dehydrogenase (DHOD) class 1B FMN-binding domain. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine...; Region: DHOD_1B_like; cd04740
365659002859	heterodimer interface [polypeptide binding]; other site
365659002860	active site
365659002861	FMN binding site [chemical binding]; other site
365659002862	homodimer interface [polypeptide binding]; other site
365659002863	substrate binding site [chemical binding]; other site
365659002864	FOG: Glucan-binding domain (YG repeat) [General function prediction only]; Region: COG5263
365659002865	Beta- N-acetylglucosaminidase [Carbohydrate transport and metabolism]; Region: LytD; COG4193
365659002866	Lysozyme subfamily 2; Region: LYZ2; smart00047
365659002867	Predicted RNA-binding protein homologous to eukaryotic snRNP [Transcription]; Region: COG1293
365659002868	Domain of unknown function (DUF814); Region: DUF814; pfam05670
365659002869	metal-binding heat shock protein; Provisional; Region: PRK00016
365659002870	Diacylglycerol kinase [Cell envelope biogenesis, outer membrane]; Region: DgkA; COG0818
365659002871	GTPase Era; Reviewed; Region: era; PRK00089
365659002872	E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163
365659002873	G1 box; other site
365659002874	GTP/Mg2+ binding site [chemical binding]; other site
365659002875	Switch I region; other site
365659002876	G2 box; other site
365659002877	Switch II region; other site
365659002878	G3 box; other site
365659002879	G4 box; other site
365659002880	G5 box; other site
365659002881	KH domain; Region: KH_2; pfam07650
365659002882	formamidopyrimidine/5-formyluracil/ 5-hydroxymethyluracil DNA glycosylase; Validated; Region: PRK01103
365659002883	N-terminal domain of Escherichia coli Fpg1/MutM and related bacterial DNA glycosylases; Region: EcFpg-like_N; cd08966
365659002884	DNA binding site [nucleotide binding]
365659002885	catalytic residue [active]
365659002886	H2TH interface [polypeptide binding]; other site
365659002887	putative catalytic residues [active]
365659002888	turnover-facilitating residue; other site
365659002889	intercalation triad [nucleotide binding]; other site
365659002890	8OG recognition residue [nucleotide binding]; other site
365659002891	putative reading head residues; other site
365659002892	Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831
365659002893	Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827
365659002894	Dephospho-CoA kinase [Coenzyme metabolism]; Region: CoaE; COG0237
365659002895	Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022
365659002896	CoA-binding site [chemical binding]; other site
365659002897	ATP-binding [chemical binding]; other site
365659002898	drug efflux system protein MdtG; Provisional; Region: PRK09874
365659002899	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
365659002900	putative substrate translocation pore; other site
365659002901	50S ribosomal protein L33; Validated; Region: rpmG; PRK00595
365659002902	Preprotein translocase subunit SecG [Intracellular trafficking and secretion]; Region: SecG; COG1314
365659002903	ribonuclease R; Region: RNase_R; TIGR02063
365659002904	Ribonuclease B OB domain; Region: OB_RNB; pfam08206
365659002905	RNB domain; Region: RNB; pfam00773
365659002906	S1_RNase_R: RNase R C-terminal S1 domain. RNase R is a processive 3' to 5' exoribonuclease, which is a homolog of RNase II. RNase R degrades RNA with secondary structure having a 3' overhang of at least 7 nucleotides. RNase R and PNPase...; Region: S1_RNase_R; cd04471
365659002907	RNA binding site [nucleotide binding]; other site
365659002908	Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294
365659002909	SmpB-tmRNA interface; other site
365659002910	tellurite resistance protein TehB; Provisional; Region: PRK12335
365659002911	Uncharacterized protein/domain, possibly involved in tellurite resistance [Inorganic ion transport and metabolism]; Region: TehB; COG3615
365659002912	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
365659002913	S-adenosylmethionine binding site [chemical binding]; other site
365659002914	SasC/Mrp/FmtB intercellular aggregation domain; Region: SasC_Mrp_aggreg; TIGR04263
365659002915	Competence protein CoiA-like family; Region: CoiA; cl11541
365659002916	Oligoendopeptidase F [Amino acid transport and metabolism]; Region: COG1164
365659002917	Peptidase family M3B Oligopeptidase F (PepF); Region: M3B_PepF_3; cd09608
365659002918	active site
365659002919	Zn binding site [ion binding]; other site
365659002920	Predicted O-methyltransferase [General function prediction only]; Region: COG4122
365659002921	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
365659002922	S-adenosylmethionine binding site [chemical binding]; other site
365659002923	foldase protein PrsA; Reviewed; Region: prsA; PRK01326
365659002924	PPIC-type PPIASE domain; Region: Rotamase; pfam00639
365659002925	Bacterial cell division membrane protein [Cell division and chromosome partitioning]; Region: FtsW; COG0772
365659002926	phosphoenolpyruvate carboxylase; Reviewed; Region: PRK00009
365659002927	Phosphoenolpyruvate carboxylase [Energy production and conversion]; Region: Ppc; COG2352
365659002928	Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826
365659002929	Helix-turn-helix domain; Region: HTH_38; pfam13936
365659002930	Integrase core domain; Region: rve; pfam00665
365659002931	Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826
365659002932	Helix-turn-helix domain; Region: HTH_38; pfam13936
365659002933	Integrase core domain; Region: rve; pfam00665
365659002934	Type I periplasmic ligand-binding domain of uncharacterized ABC-type transport systems that are predicted to be involved in the uptake of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_uncharacterized_transporter; cd06325
365659002935	Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407
365659002936	zinc binding site [ion binding]; other site
365659002937	putative ligand binding site [chemical binding]; other site
365659002938	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
365659002939	Transmembrane subunit (TM) of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which are involved in the uptake of branched-chain amino acids (AAs), as well as TMs of transporters involved in the uptake of...; Region: TM_PBP1_branched-chain-AA_like; cd06574
365659002940	TM-ABC transporter signature motif; other site
365659002941	ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: PhnK; COG1101
365659002942	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
365659002943	Walker A/P-loop; other site
365659002944	ATP binding site [chemical binding]; other site
365659002945	Q-loop/lid; other site
365659002946	ABC transporter signature motif; other site
365659002947	Walker B; other site
365659002948	D-loop; other site
365659002949	H-loop/switch region; other site
365659002950	DNA primase; Validated; Region: dnaG; PRK05667
365659002951	CHC2 zinc finger; Region: zf-CHC2; pfam01807
365659002952	DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275
365659002953	TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364
365659002954	active site
365659002955	metal binding site [ion binding]; metal-binding site
365659002956	interdomain interaction site; other site
365659002957	RNA polymerase sigma factor RpoD; Validated; Region: PRK09210
365659002958	Sigma-70 factor, region 1.1; Region: Sigma70_r1_1; pfam03979
365659002959	Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140
365659002960	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
365659002961	Sigma-70 region 3; Region: Sigma70_r3; pfam04539
365659002962	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
365659002963	DNA binding residues [nucleotide binding]
365659002964	Predicted metal-sulfur cluster biosynthetic enzyme [General function prediction only]; Region: PaaD; COG2151
365659002965	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
365659002966	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
365659002967	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
365659002968	This family is most closely related to the GT1 family of glycosyltransferases. UDP-glucose-diacylglycerol glucosyltransferase (UGDG; also known as 1,2-diacylglycerol 3-glucosyltransferase) catalyzes the transfer of glucose from UDP-glucose to 1; Region: GT1_UGDG_like; cd03817
365659002969	putative ADP-binding pocket [chemical binding]; other site
365659002970	Putative stress-responsive transcriptional regulator [Transcription / Signal transduction mechanisms]; Region: PspC; COG1983
365659002971	Protein of unknown function (DUF4044); Region: DUF4044; pfam13253
365659002972	GTPase CgtA; Reviewed; Region: obgE; PRK12297
365659002973	GTP1/OBG; Region: GTP1_OBG; pfam01018
365659002974	Obg GTPase; Region: Obg; cd01898
365659002975	G1 box; other site
365659002976	GTP/Mg2+ binding site [chemical binding]; other site
365659002977	Switch I region; other site
365659002978	G2 box; other site
365659002979	G3 box; other site
365659002980	Switch II region; other site
365659002981	G4 box; other site
365659002982	G5 box; other site
365659002983	Domain of unknown function (DUF1967); Region: DUF1967; pfam09269
365659002984	Arginine repressor [Transcription]; Region: ArgR; COG1438
365659002985	Arginine repressor, DNA binding domain; Region: Arg_repressor; pfam01316
365659002986	Arginine repressor, C-terminal domain; Region: Arg_repressor_C; pfam02863
365659002987	x-prolyl-dipeptidyl aminopeptidase; Provisional; Region: PRK05371
365659002988	X-Prolyl dipeptidyl aminopeptidase PepX, N-terminal; Region: PepX_N; pfam09168
365659002989	X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain; Region: PepX_C; pfam08530
365659002990	YSIRK type signal peptide; Region: YSIRK_signal; pfam04650
365659002991	CshA-type fibril repeat; Region: CshA_fibril_rpt; TIGR04225
365659002992	MucBP domain; Region: MucBP; pfam06458
365659002993	MucBP domain; Region: MucBP; pfam06458
365659002994	MucBP domain; Region: MucBP; pfam06458
365659002995	MucBP domain; Region: MucBP; pfam06458
365659002996	MucBP domain; Region: MucBP; pfam06458
365659002997	DNA polymerase III DnaE; Reviewed; Region: dnaE; PRK07279
365659002998	Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III; Region: PHP_PolIIIA; cd07431
365659002999	active site
365659003000	PHP Thumb interface [polypeptide binding]; other site
365659003001	DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485
365659003002	generic binding surface I; other site
365659003003	generic binding surface II; other site
365659003004	Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to a subfamily of the PFKA family (cd00363) and include bacterial ATP-dependent...; Region: Bacterial_PFK; cd00763
365659003005	6-phosphofructokinase; Region: PFKA_ATP; TIGR02482
365659003006	active site
365659003007	ADP/pyrophosphate binding site [chemical binding]; other site
365659003008	dimerization interface [polypeptide binding]; other site
365659003009	allosteric effector site; other site
365659003010	fructose-1,6-bisphosphate binding site; other site
365659003011	pyruvate kinase; Provisional; Region: PRK05826
365659003012	Pyruvate kinase (PK):  Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342
365659003013	domain interfaces; other site
365659003014	active site
365659003015	L-lactate dehydrogenase; Reviewed; Region: ldh; PRK00066
365659003016	L-2-hydroxyisocapronate dehydrogenases and some bacterial L-lactate dehydrogenases; Region: HicDH_like; cd05291
365659003017	tetramer (dimer of dimers) interface [polypeptide binding]; other site
365659003018	NAD binding site [chemical binding]; other site
365659003019	dimer interface [polypeptide binding]; other site
365659003020	substrate binding site [chemical binding]; other site
365659003021	DNA gyrase subunit A; Validated; Region: PRK05560
365659003022	DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187
365659003023	CAP-like domain; other site
365659003024	active site
365659003025	primary dimer interface [polypeptide binding]; other site
365659003026	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
365659003027	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
365659003028	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
365659003029	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
365659003030	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
365659003031	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
365659003032	Sortase A (SrtA) or subfamily-1 sortases are cysteine transpeptidases found in gram-positive bacteria that anchor surface proteins to peptidoglycans of the bacterial cell wall envelope. They do so by catalyzing a transpeptidation reaction in which the...; Region: Sortase_A_1; cd06165
365659003033	active site
365659003034	catalytic site [active]
365659003035	Formate/nitrite family of transporters [Inorganic ion transport and metabolism]; Region: FocA; COG2116
365659003036	O-acetylhomoserine sulfhydrylase [Amino acid transport and metabolism]; Region: MET17; COG2873
365659003037	CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614
365659003038	homodimer interface [polypeptide binding]; other site
365659003039	substrate-cofactor binding pocket; other site
365659003040	pyridoxal 5'-phosphate binding site [chemical binding]; other site
365659003041	catalytic residue [active]
365659003042	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4487
365659003043	Uncharacterized protein conserved in bacteria (DUF2130); Region: DUF2130; pfam09903
365659003044	tRNA pseudouridine synthase B; Provisional; Region: truB; PRK02484
365659003045	Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573
365659003046	RNA binding site [nucleotide binding]; other site
365659003047	active site
365659003048	tRNA Pseudouridine synthase II, C terminal; Region: TruB_C; pfam09142
365659003049	Uridine kinase [Nucleotide transport and metabolism]; Region: Udk; COG0572
365659003050	Uridine monophosphate kinase (UMPK, EC 2.7.1.48), also known as uridine kinase or uridine-cytidine kinase (UCK), catalyzes the reversible phosphoryl transfer from ATP to uridine or cytidine to yield UMP or CMP. In the primidine nucleotide-salvage pathway; Region: UMPK; cd02023
365659003051	Sugar specificity; other site
365659003052	Pyrimidine base specificity; other site
365659003053	ATP-binding site [chemical binding]; other site
365659003054	exodeoxyribonuclease VII large subunit; Reviewed; Region: xseA; PRK00286
365659003055	ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489
365659003056	generic binding surface II; other site
365659003057	generic binding surface I; other site
365659003058	exodeoxyribonuclease VII small subunit; Provisional; Region: PRK00977
365659003059	Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142
365659003060	Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685
365659003061	substrate binding pocket [chemical binding]; other site
365659003062	chain length determination region; other site
365659003063	substrate-Mg2+ binding site; other site
365659003064	catalytic residues [active]
365659003065	aspartate-rich region 1; other site
365659003066	active site lid residues [active]
365659003067	aspartate-rich region 2; other site
365659003068	Predicted rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: COG1189
365659003069	S4 RNA-binding domain; Region: S4; smart00363
365659003070	RNA binding surface [nucleotide binding]; other site
365659003071	FtsJ-like methyltransferase; Region: FtsJ; pfam01728
365659003072	Arginine repressor [Transcription]; Region: ArgR; COG1438
365659003073	Arginine repressor, DNA binding domain; Region: Arg_repressor; pfam01316
365659003074	Arginine repressor, C-terminal domain; Region: Arg_repressor_C; pfam02863
365659003075	ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: RecN; COG0497
365659003076	ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241
365659003077	Walker A/P-loop; other site
365659003078	ATP binding site [chemical binding]; other site
365659003079	Q-loop/lid; other site
365659003080	ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241
365659003081	Q-loop/lid; other site
365659003082	ABC transporter signature motif; other site
365659003083	Walker B; other site
365659003084	D-loop; other site
365659003085	H-loop/switch region; other site
365659003086	phosphoprotein phosphatases of the metallophosphatase superfamily, metallophosphatase domain; Region: MPP_PPP_family; cd00144
365659003087	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
365659003088	active site
365659003089	metal binding site [ion binding]; metal-binding site
365659003090	GTP-binding protein LepA; Provisional; Region: PRK05433
365659003091	LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890
365659003092	G1 box; other site
365659003093	putative GEF interaction site [polypeptide binding]; other site
365659003094	GTP/Mg2+ binding site [chemical binding]; other site
365659003095	Switch I region; other site
365659003096	G2 box; other site
365659003097	G3 box; other site
365659003098	Switch II region; other site
365659003099	G4 box; other site
365659003100	G5 box; other site
365659003101	lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699
365659003102	lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane.   LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709
365659003103	GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421
365659003104	PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211
365659003105	active site
365659003106	phosphorylation site [posttranslational modification]
365659003107	PTS_IIB_galactitol: subunit IIB of enzyme II (EII) of the galactitol-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS).  In this system, EII is a galactitol-specific permease with two cytoplasmic domains (IIA and IIB) and a...; Region: PTS_IIB_galactitol; cd05566
365659003108	active site
365659003109	P-loop; other site
365659003110	phosphorylation site [posttranslational modification]
365659003111	Phosphotransferase system, galactitol-specific IIC component [Carbohydrate transport and metabolism]; Region: GatC; COG3775
365659003112	PTS system sugar-specific permease component; Region: EIIC-GAT; pfam03611
365659003113	Aldose 1-epimerase, similar to Lactococcus lactis lacX; Region: Aldose_epim_lacX; cd09024
365659003114	active site
365659003115	catalytic residues [active]
365659003116	galactose-6-phosphate isomerase subunit LacA; Reviewed; Region: PRK08621
365659003117	galactose-6-phosphate isomerase subunit LacB; Reviewed; Region: PRK08622
365659003118	1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164
365659003119	tagatose-6-phosphate kinase; Region: lacC; TIGR01231
365659003120	putative substrate binding site [chemical binding]; other site
365659003121	putative ATP binding site [chemical binding]; other site
365659003122	tagatose 1,6-diphosphate aldolase; Reviewed; Region: PRK12399
365659003123	galactose-6-phosphate isomerase subunit LacB; Reviewed; Region: PRK08622
365659003124	Ribose/Galactose Isomerase; Region: LacAB_rpiB; cl00485
365659003125	Predicted transcriptional regulator [Transcription]; Region: COG1959
365659003126	Transcriptional regulator; Region: Rrf2; pfam02082
365659003127	Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950
365659003128	EamA-like transporter family; Region: EamA; pfam00892
365659003129	EamA-like transporter family; Region: EamA; pfam00892
365659003130	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173
365659003131	Methyltransferase domain; Region: Methyltransf_31; pfam13847
365659003132	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
365659003133	S-adenosylmethionine binding site [chemical binding]; other site
365659003134	CAT RNA binding domain; Region: CAT_RBD; smart01061
365659003135	transcriptional antiterminator BglG; Provisional; Region: PRK09772
365659003136	PRD domain; Region: PRD; pfam00874
365659003137	PRD domain; Region: PRD; pfam00874
365659003138	PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_lac; cd00215
365659003139	methionine cluster; other site
365659003140	active site
365659003141	phosphorylation site [posttranslational modification]
365659003142	metal binding site [ion binding]; metal-binding site
365659003143	Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; cl17295
365659003144	Phosphotransferase system, EIIC; Region: PTS_EIIC; pfam02378
365659003145	PTS_IIB: subunit IIB of enzyme II (EII) is the central energy-coupling domain of the phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In the multienzyme PTS complex, EII is a carbohydrate-specific permease consisting of two cytoplasmic...; Region: PTS_IIB; cl10014
365659003146	active site
365659003147	P-loop; other site
365659003148	phosphorylation site [posttranslational modification]
365659003149	6-phospho-beta-galactosidase; Provisional; Region: PRK13511
365659003150	beta-galactosidase; Region: BGL; TIGR03356
365659003151	Protein of unknown function (DUF3884); Region: DUF3884; pfam13024
365659003152	Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349
365659003153	DeoR-like helix-turn-helix domain; Region: HTH_DeoR; pfam08220
365659003154	DeoR C terminal sensor domain; Region: DeoRC; pfam00455
365659003155	ribonucleotide-diphosphate reductase subunit beta; Provisional; Region: nrdF2; PRK13966
365659003156	Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049
365659003157	dimer interface [polypeptide binding]; other site
365659003158	putative radical transfer pathway; other site
365659003159	diiron center [ion binding]; other site
365659003160	tyrosyl radical; other site
365659003161	ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK07306
365659003162	Ribonucleotide reductase N-terminal; Region: RNR_N; pfam08343
365659003163	Class I ribonucleotide reductase; Region: RNR_I; cd01679
365659003164	active site
365659003165	dimer interface [polypeptide binding]; other site
365659003166	catalytic residues [active]
365659003167	effector binding site; other site
365659003168	Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939
365659003169	NrdH-redoxin (NrdH) family; NrdH is a small monomeric protein with a conserved redox active CXXC motif within a TRX fold, characterized by a glutaredoxin (GRX)-like sequence and TRX-like activity profile. In vitro, it displays protein disulfide reductase...; Region: NrdH; cd02976
365659003170	catalytic residues [active]
365659003171	Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367
365659003172	dimerization domain swap beta strand [polypeptide binding]; other site
365659003173	regulatory protein interface [polypeptide binding]; other site
365659003174	active site
365659003175	regulatory phosphorylation site [posttranslational modification]; other site
365659003176	Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism]; Region: PtsA; COG1080
365659003177	PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524
365659003178	PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391
365659003179	PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896
365659003180	Flagellin N-methylase; Region: FliB; pfam03692
365659003181	Protein of unknown function (DUF1706); Region: DUF1706; pfam08020
365659003182	DhaKLM operon coactivator DhaQ; Provisional; Region: PRK14483
365659003183	Dihydroxyacetone kinase [Carbohydrate transport and metabolism]; Region: DAK1; COG2376
365659003184	probable dihydroxyacetone kinase regulator; Region: DHAK_reg; TIGR02366
365659003185	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
365659003186	dihydroxyacetone kinase subunit DhaK; Provisional; Region: PRK14481
365659003187	Dihydroxyacetone kinase [Carbohydrate transport and metabolism]; Region: DAK1; COG2376
365659003188	dihydroxyacetone kinase, phosphoprotein-dependent, L subunit; Region: dha_L_ycgS; TIGR02365
365659003189	PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cl00025
365659003190	HAD superfamily (subfamily IA) hydrolase, TIGR02254; Region: YjjG/YfnB
365659003191	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
365659003192	motif II; other site
365659003193	Family 1 of Uracil-DNA glycosylase (UDG) enzymes; Region: UDG_F1; cd10027
365659003194	ligand binding site [chemical binding]; other site
365659003195	active site
365659003196	UGI interface [polypeptide binding]; other site
365659003197	catalytic site [active]
365659003198	MutT homolog-1 (MTH1) is a member of the Nudix hydrolase superfamily. MTH1, the mammalian counterpart of MutT, hydrolyzes oxidized purine nucleoside triphosphates, such as 8-oxo-dGTP and 2-hydroxy-ATP, to monophosphates, thereby preventing the...; Region: MTH1; cd03427
365659003199	putative active site [active]
365659003200	nucleotide binding site [chemical binding]; other site
365659003201	nudix motif; other site
365659003202	putative metal binding site [ion binding]; other site
365659003203	dihydroorotase; Validated; Region: pyrC; PRK09357
365659003204	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
365659003205	Dihydroorotase (DHOase), subgroup IIa; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This subgroup also contains proteins that lack the active site, like unc-33, a C; Region: DHOase_IIa; cd01317
365659003206	active site
365659003207	Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Vibrio cholerae NorM; Region: MATE_NorM_like; cd13131
365659003208	multidrug efflux protein; Reviewed; Region: PRK01766
365659003209	cation binding site [ion binding]; other site
365659003210	site-specific tyrosine recombinase XerS; Reviewed; Region: xerS; PRK05084
365659003211	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
365659003212	active site
365659003213	DNA binding site [nucleotide binding]
365659003214	Int/Topo IB signature motif; other site
365659003215	MepB protein; Region: MepB; cl01985
365659003216	ClC chloride channel EriC.  This domain is found in the EriC chloride transporters that mediate the extreme acid resistance response in eubacteria and archaea. This response allows bacteria to survive in the acidic environments by decarboxylation-linked...; Region: EriC; cd01031
365659003217	Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038
365659003218	Cl- selectivity filter; other site
365659003219	Cl- binding residues [ion binding]; other site
365659003220	pore gating glutamate residue; other site
365659003221	dimer interface [polypeptide binding]; other site
365659003222	H+/Cl- coupling transport residue; other site
365659003223	TrkA-C domain; Region: TrkA_C; pfam02080
365659003224	bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182
365659003225	RNA/DNA hybrid binding site [nucleotide binding]; other site
365659003226	active site
365659003227	GTPase YlqF; Reviewed; Region: rbgA; PRK09563
365659003228	Circularly permuted YlqF GTPase; Region: YlqF; cd01856
365659003229	GTP/Mg2+ binding site [chemical binding]; other site
365659003230	G4 box; other site
365659003231	G5 box; other site
365659003232	Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170
365659003233	G1 box; other site
365659003234	G1 box; other site
365659003235	GTP/Mg2+ binding site [chemical binding]; other site
365659003236	Switch I region; other site
365659003237	G2 box; other site
365659003238	G2 box; other site
365659003239	G3 box; other site
365659003240	G3 box; other site
365659003241	Switch II region; other site
365659003242	Switch II region; other site
365659003243	G5 box; other site
365659003244	MucBP domain; Region: MucBP; pfam06458
365659003245	MucBP domain; Region: MucBP; pfam06458
365659003246	surface protein repeat SSSPR-51; Region: repeat_SSSPR51; TIGR04308
365659003247	helicase-exonuclease AddAB, AddA subunit, Firmicutes type; Region: addA_Gpos; TIGR02785
365659003248	Part of AAA domain; Region: AAA_19; pfam13245
365659003249	Family description; Region: UvrD_C_2; pfam13538
365659003250	Family description; Region: UvrD_C_2; pfam13538
365659003251	PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705
365659003252	ATP-dependent nuclease subunit B; Region: rexB_recomb; TIGR02774
365659003253	PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705
365659003254	Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826
365659003255	Helix-turn-helix domain; Region: HTH_38; pfam13936
365659003256	Integrase core domain; Region: rve; pfam00665
365659003257	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
365659003258	haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282
365659003259	active site
365659003260	motif I; other site
365659003261	motif II; other site
365659003262	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
365659003263	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
365659003264	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
365659003265	Walker A/P-loop; other site
365659003266	ATP binding site [chemical binding]; other site
365659003267	Q-loop/lid; other site
365659003268	ABC transporter signature motif; other site
365659003269	Walker B; other site
365659003270	D-loop; other site
365659003271	H-loop/switch region; other site
365659003272	ABC-2 family transporter protein; Region: ABC2_membrane_2; cl17866
365659003273	ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730
365659003274	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
365659003275	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
365659003276	dimer interface [polypeptide binding]; other site
365659003277	phosphorylation site [posttranslational modification]
365659003278	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
365659003279	ATP binding site [chemical binding]; other site
365659003280	Mg2+ binding site [ion binding]; other site
365659003281	G-X-G motif; other site
365659003282	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
365659003283	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
365659003284	active site
365659003285	phosphorylation site [posttranslational modification]
365659003286	intermolecular recognition site; other site
365659003287	dimerization interface [polypeptide binding]; other site
365659003288	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
365659003289	DNA binding site [nucleotide binding]
365659003290	Nodulin-21 and CCC1-related protein family; Region: Nodulin-21_like_1; cd02432
365659003291	FtsX-like permease family; Region: FtsX; pfam02687
365659003292	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
365659003293	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
365659003294	Walker A/P-loop; other site
365659003295	ATP binding site [chemical binding]; other site
365659003296	Q-loop/lid; other site
365659003297	ABC transporter signature motif; other site
365659003298	Walker B; other site
365659003299	D-loop; other site
365659003300	H-loop/switch region; other site
365659003301	Putative stress-responsive transcriptional regulator [Transcription / Signal transduction mechanisms]; Region: PspC; COG1983
365659003302	SprT homologues; Region: SprT; cl01182
365659003303	hypothetical protein; Provisional; Region: PRK04351
365659003304	Transcriptional accessory protein [Transcription]; Region: Tex; COG2183
365659003305	Tex-like protein N-terminal domain; Region: Tex_N; pfam09371
365659003306	Likely ribonuclease with RNase H fold; Region: YqgFc; smart00732
365659003307	S1_Tex: The C-terminal S1 domain of a transcription accessory factor called Tex, which has been characterized in Bordetella pertussis and Pseudomonas aeruginosa. The tex gene is essential in Bortella pertusis and is named for its role in toxin expression; Region: S1_Tex; cd05685
365659003308	RNA binding site [nucleotide binding]; other site
365659003309	Predicted permeases [General function prediction only]; Region: COG0701
365659003310	Predicted membrane protein [Function unknown]; Region: COG3689
365659003311	Helix-turn-helix domain; Region: HTH_38; pfam13936
365659003312	Integrase core domain; Region: rve; pfam00665
365659003313	Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695
365659003314	haloacid dehalogenase-like hydrolase; Region: HAD; cl17202
365659003315	Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210
365659003316	Part of AAA domain; Region: AAA_19; pfam13245
365659003317	Family description; Region: UvrD_C_2; pfam13538
365659003318	PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705
365659003319	PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705
365659003320	ATP-binding subunits of Clp protease and DnaK/DnaJ chaperones [Posttranslational modification, protein turnover, chaperones]; Region: clpA; COG0542
365659003321	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
365659003322	Walker A motif; other site
365659003323	ATP binding site [chemical binding]; other site
365659003324	Walker B motif; other site
365659003325	arginine finger; other site
365659003326	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
365659003327	Walker A motif; other site
365659003328	ATP binding site [chemical binding]; other site
365659003329	Walker B motif; other site
365659003330	WYL domain; Region: WYL; pfam13280
365659003331	Predicted P-loop ATPase [General function prediction only]; Region: COG4928
365659003332	KAP family P-loop domain; Region: KAP_NTPase; pfam07693
365659003333	Phosphoserine phosphatase [Amino acid transport and metabolism]; Region: SerB; COG0560
365659003334	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
365659003335	active site
365659003336	motif I; other site
365659003337	motif II; other site
365659003338	Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317
365659003339	HD domain; Region: HD_4; pfam13328
365659003340	GIY-YIG domain of uncharacterized proteins from bacteria and their eukaryotic homologs; Region: GIY-YIG_COG3680; cd10440
365659003341	GIY-YIG motif/motif A; other site
365659003342	putative active site [active]
365659003343	putative metal binding site [ion binding]; other site
365659003344	Zeta toxin; Region: Zeta_toxin; pfam06414
365659003345	Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190
365659003346	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
365659003347	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
365659003348	non-specific DNA binding site [nucleotide binding]; other site
365659003349	salt bridge; other site
365659003350	sequence-specific DNA binding site [nucleotide binding]; other site
365659003351	N-terminal Early set domain associated with the catalytic domain of cyclomaltodextrinase and pullulan-degrading enzymes; Region: E_set_CDase_PDE_N; cd02857
365659003352	homodimer interface [polypeptide binding]; other site
365659003353	Alpha amylase catalytic domain found in cyclomaltodextrinases and related proteins; Region: AmyAc_CMD; cd11338
365659003354	Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366
365659003355	active site
365659003356	homodimer interface [polypeptide binding]; other site
365659003357	catalytic site [active]
365659003358	Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase [Lipid metabolism / General function prediction only]; Region: LCB5; COG1597
365659003359	Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781
365659003360	ADP-ribosylglycohydrolase [Posttranslational modification, protein turnover, chaperones]; Region: DraG; COG1397
365659003361	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
365659003362	HEAT repeats; Region: HEAT_2; pfam13646
365659003363	DNA alkylation repair enzyme [DNA replication, recombination, and repair]; Region: COG4335
365659003364	Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020
365659003365	conserved cys residue [active]
365659003366	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
365659003367	Coenzyme A binding pocket [chemical binding]; other site
365659003368	Domain of unknown function (DUF4343); Region: DUF4343; pfam14243
365659003369	SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase [Translation, ribosomal structure and biogenesis]; Region: TrmA; COG2265
365659003370	Predicted RNA-binding protein, contains TRAM domain [General function prediction only]; Region: COG3269
365659003371	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
365659003372	S-adenosylmethionine binding site [chemical binding]; other site
365659003373	Predicted secreted protein [Function unknown]; Region: COG4086
365659003374	Protein of unknown function (DUF1002); Region: DUF1002; pfam06207
365659003375	Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741
365659003376	Lysozyme-like; Region: Lysozyme_like; pfam13702
365659003377	catalytic residue [active]
365659003378	37-kD nucleoid-associated bacterial protein; Region: NA37; cl15473
365659003379	serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011
365659003380	Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378
365659003381	dimer interface [polypeptide binding]; other site
365659003382	active site
365659003383	glycine-pyridoxal phosphate binding site [chemical binding]; other site
365659003384	folate binding site [chemical binding]; other site
365659003385	ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575
365659003386	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
365659003387	Coenzyme A binding pocket [chemical binding]; other site
365659003388	Putative translation factor (SUA5) [Translation, ribosomal structure and biogenesis]; Region: SUA5; COG0009
365659003389	protein-(glutamine-N5) methyltransferase, release factor-specific; Region: RF_mod_PrmC; TIGR03534
365659003390	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
365659003391	S-adenosylmethionine binding site [chemical binding]; other site
365659003392	Replication protein A, class 2b aminoacyl-tRNA synthetases, and related proteins with oligonucleotide/oligosaccharide (OB) fold; Region: RPA_2b-aaRSs_OBF_like; cl09930
365659003393	peptide chain release factor 1; Validated; Region: prfA; PRK00591
365659003394	This domain is found in peptide chain release factors; Region: PCRF; smart00937
365659003395	RF-1 domain; Region: RF-1; pfam00472
365659003396	Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670
365659003397	Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583
365659003398	Coenzyme A binding pocket [chemical binding]; other site
365659003399	thymidine kinase; Provisional; Region: PRK04296
365659003400	4-oxalocrotonate tautomerase; Provisional; Region: PRK02289
365659003401	active site 1 [active]
365659003402	dimer interface [polypeptide binding]; other site
365659003403	hexamer interface [polypeptide binding]; other site
365659003404	active site 2 [active]
365659003405	tRNA modification GTPase TrmE; Reviewed; Region: trmE; PRK05291
365659003406	GTP-binding protein TrmE N-terminus; Region: TrmE_N; pfam10396
365659003407	trmE is a tRNA modification GTPase; Region: trmE; cd04164
365659003408	G1 box; other site
365659003409	GTP/Mg2+ binding site [chemical binding]; other site
365659003410	Switch I region; other site
365659003411	G2 box; other site
365659003412	Switch II region; other site
365659003413	G3 box; other site
365659003414	G4 box; other site
365659003415	G5 box; other site
365659003416	Catalytic cysteine-containing C-terminus of GTPase, MnmE; Region: GTPase_Cys_C; pfam12631
365659003417	Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950
365659003418	Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329
365659003419	dimer interface [polypeptide binding]; other site
365659003420	active site
365659003421	catalytic residue [active]
365659003422	aspartate-semialdehyde dehydrogenase; Provisional; Region: PRK14874
365659003423	Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859
365659003424	Predicted membrane protein [Function unknown]; Region: COG4708
365659003425	Predicted membrane protein [Function unknown]; Region: COG2246
365659003426	GtrA-like protein; Region: GtrA; pfam04138
365659003427	Large-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscL; COG1970
365659003428	large-conductance mechanosensitive channel; Reviewed; Region: mscL; PRK00567
365659003429	Protoheme ferro-lyase (ferrochelatase) [Coenzyme metabolism]; Region: HemH; COG0276
365659003430	Class II Chelatase: a family of ATP-independent monomeric or homodimeric enzymes that catalyze the insertion of metal into protoporphyrin rings. This family includes protoporphyrin IX ferrochelatase (HemH), sirohydrochlorin ferrochelatase (SirB) and the...; Region: Chelatase_Class_II; cl02784
365659003431	active site
365659003432	Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419
365659003433	active site
365659003434	N-terminal domain interface [polypeptide binding]; other site
365659003435	peptidase T; Region: peptidase-T; TIGR01882
365659003436	M20 Peptidase T specifically cleaves tripeptides; Region: M20_peptT; cd03892
365659003437	metal binding site [ion binding]; metal-binding site
365659003438	dimer interface [polypeptide binding]; other site
365659003439	RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651
365659003440	Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078
365659003441	putative active site [active]
365659003442	putative NTP binding site [chemical binding]; other site
365659003443	putative nucleic acid binding site [nucleotide binding]; other site
365659003444	Group II intron, maturase-specific domain; Region: GIIM; pfam08388
365659003445	streptococcal histidine triad protein; Region: strep_his_triad; TIGR01363
365659003446	Streptococcal histidine triad protein; Region: Strep_his_triad; pfam04270
365659003447	Streptococcal histidine triad protein; Region: Strep_his_triad; pfam04270
365659003448	Streptococcal histidine triad protein; Region: Strep_his_triad; pfam04270
365659003449	Streptococcal histidine triad protein; Region: Strep_his_triad; pfam04270
365659003450	Streptococcal histidine triad protein; Region: Strep_his_triad; pfam04270
365659003451	Streptococcal histidine triad protein; Region: Strep_his_triad; pfam04270
365659003452	Streptococcal histidine triad protein; Region: Strep_his_triad; pfam04270
365659003453	Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403
365659003454	streptococcal histidine triad protein; Region: strep_his_triad; TIGR01363
365659003455	Streptococcal histidine triad protein; Region: Strep_his_triad; pfam04270
365659003456	Streptococcal histidine triad protein; Region: Strep_his_triad; pfam04270
365659003457	Streptococcal histidine triad protein; Region: Strep_his_triad; pfam04270
365659003458	Streptococcal histidine triad protein; Region: Strep_his_triad; pfam04270
365659003459	Streptococcal histidine triad protein; Region: Strep_his_triad; pfam04270
365659003460	ABC-type metal ion transport system, periplasmic component/surface adhesin [Inorganic ion transport and metabolism]; Region: LraI; COG0803
365659003461	Metal binding protein AcdA.  These proteins have been shown to function in the ABC uptake of Zn2+ and Mn2+ and in competence for genetic transformation and adhesion. The AcdA proteins belong to the TroA superfamily of helical backbone metal receptor...; Region: AdcA; cd01017
365659003462	metal binding site [ion binding]; metal-binding site
365659003463	amino acid transporter; Region: 2A0306; TIGR00909
365659003464	C-terminus of AA_permease; Region: AA_permease_C; pfam13906
365659003465	TlpA-like family; composed of  TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966
365659003466	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
365659003467	catalytic residues [active]
365659003468	Cytochrome c biogenesis protein [Posttranslational modification, protein turnover, chaperones]; Region: CcdA; COG0785
365659003469	Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788
365659003470	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3293
365659003471	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
365659003472	DDE superfamily endonuclease; Region: DDE_4_2; pfam13613
365659003473	Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788
365659003474	Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591
365659003475	IHF dimer interface [polypeptide binding]; other site
365659003476	IHF - DNA interface [nucleotide binding]; other site
365659003477	EDD domain protein, DegV family; Region: DegV; TIGR00762
365659003478	Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645
365659003479	Uncharacterized conserved protein [Function unknown]; Region: COG1284
365659003480	Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588
365659003481	Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588
365659003482	Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035
365659003483	bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627
365659003484	FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064
365659003485	active site
365659003486	Riboflavin kinase; Region: Flavokinase; smart00904
365659003487	Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086
365659003488	active site
365659003489	Predicted transcriptional regulator containing CBS domains [Transcription]; Region: COG4109
365659003490	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
365659003491	DNA-binding site [nucleotide binding]; DNA binding site
365659003492	DRTGG domain; Region: DRTGG; pfam07085
365659003493	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with a DRTGG domain upstream. The function of the DRTGG domain, named after its conserved residues, is unknown. CBS is a small domain originally...; Region: CBS_pair_DRTGG_assoc; cd04596
365659003494	The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cd03440
365659003495	active site 2 [active]
365659003496	active site 1 [active]
365659003497	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
365659003498	Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583
365659003499	UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072
365659003500	UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555
365659003501	hinge; other site
365659003502	active site
365659003503	Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826
365659003504	Helix-turn-helix domain; Region: HTH_38; pfam13936
365659003505	Integrase core domain; Region: rve; pfam00665
365659003506	enolase; Provisional; Region: eno; PRK00077
365659003507	Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313
365659003508	dimer interface [polypeptide binding]; other site
365659003509	metal binding site [ion binding]; metal-binding site
365659003510	substrate binding pocket [chemical binding]; other site
365659003511	Uncharacterized conserved protein [Function unknown]; Region: COG5506
365659003512	Glycerate kinase [Carbohydrate transport and metabolism]; Region: COG1929
365659003513	phosphoserine phosphatase SerB; Region: serB; TIGR00338
365659003514	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
365659003515	motif II; other site
365659003516	glycogen synthase; Provisional; Region: glgA; PRK00654
365659003517	This family is most closely related to the GT1 family of glycosyltransferases. Glycogen synthase catalyzes the formation and elongation of the alpha-1,4-glucose backbone using ADP-glucose, the second and key step of glycogen biosynthesis. This family...; Region: GT1_Glycogen_synthase_DULL1_like; cd03791
365659003518	ADP-binding pocket [chemical binding]; other site
365659003519	homodimer interface [polypeptide binding]; other site
365659003520	glucose-1-phosphate adenylyltransferase, GlgD subunit; Region: glgD; TIGR02092
365659003521	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
365659003522	active site
365659003523	Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651
365659003524	dimer interface [polypeptide binding]; other site
365659003525	N-terminal domain interface [polypeptide binding]; other site
365659003526	sulfate 1 binding site; other site
365659003527	glucose-1-phosphate adenylyltransferase; Provisional; Region: glgC; PRK05293
365659003528	ADP-glucose pyrophosphorylase is involved in the biosynthesis of glycogen or starch; Region: ADP_Glucose_PP; cd02508
365659003529	ligand binding site; other site
365659003530	oligomer interface; other site
365659003531	Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651
365659003532	dimer interface [polypeptide binding]; other site
365659003533	N-terminal domain interface [polypeptide binding]; other site
365659003534	sulfate 1 binding site; other site
365659003535	glycogen branching enzyme; Provisional; Region: PRK12313
365659003536	N-terminal Early set domain associated with the catalytic domain of prokaryotic glycogen branching enzyme; Region: E_set_GBE_prok_N; cd02855
365659003537	Alpha amylase catalytic domain found in the Glycogen branching enzyme (also called 1,4-alpha-glucan branching enzyme); Region: AmyAc_Glg_BE; cd11322
365659003538	active site
365659003539	catalytic site [active]
365659003540	Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; pfam02806
365659003541	Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826
365659003542	Helix-turn-helix domain; Region: HTH_38; pfam13936
365659003543	Integrase core domain; Region: rve; pfam00665
365659003544	Family 41 Carbohydrate-Binding Module from pullulanase-like enzymes; Region: CBM41_pullulanase; cl04227
365659003545	pullulanase, type I; Region: pulA_typeI; TIGR02104
365659003546	Early set domain associated with the catalytic domain of pullulanase (also called dextrinase and alpha-dextrin endo-1,6-alpha glucosidase); Region: E_set_Pullulanase; cd02860
365659003547	Alpha amylase catalytic domain found in Pullulanase (also called dextrinase; alpha-dextrin endo-1,6-alpha glucosidase), limit dextrinase, and related proteins; Region: AmyAc_Pullulanase_LD-like; cd11341
365659003548	Ca binding site [ion binding]; other site
365659003549	active site
365659003550	catalytic site [active]
365659003551	NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956
365659003552	NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114
365659003553	nucleotide binding pocket [chemical binding]; other site
365659003554	K-X-D-G motif; other site
365659003555	catalytic site [active]
365659003556	NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120
365659003557	NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119
365659003558	Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027
365659003559	Dimer interface [polypeptide binding]; other site
365659003560	BRCT sequence motif; other site
365659003561	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cl17904
365659003562	putative substrate translocation pore; other site
365659003563	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
365659003564	non-specific DNA binding site [nucleotide binding]; other site
365659003565	salt bridge; other site
365659003566	sequence-specific DNA binding site [nucleotide binding]; other site
365659003567	transcriptional activator, Rgg/GadR/MutR family, C-terminal domain; Region: RGG_Cterm; TIGR01716
365659003568	ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488
365659003569	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
365659003570	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
365659003571	ABC transporter; Region: ABC_tran_2; pfam12848
365659003572	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
365659003573	phosphoglucomutase-2-like protein; Provisional; Region: PTZ00150
365659003574	This CD includes PGM2 (phosphoglucomutase 2) and PGM2L1 (phosphoglucomutase 2-like 1). The mammalian PGM2 is thought to be a phosphopentomutase that catalyzes the conversion of the nucleoside breakdown products, ribose-1-phosphate and...; Region: PGM2; cd05799
365659003575	active site
365659003576	substrate binding site [chemical binding]; other site
365659003577	metal binding site [ion binding]; metal-binding site
365659003578	TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947
365659003579	catalytic residues [active]
365659003580	Metal-dependent hydrolases of the beta-lactamase superfamily I [General function prediction only]; Region: PhnP; COG1235
365659003581	Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220
365659003582	phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966
365659003583	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
365659003584	putative active site [active]
365659003585	heme pocket [chemical binding]; other site
365659003586	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
365659003587	dimer interface [polypeptide binding]; other site
365659003588	phosphorylation site [posttranslational modification]
365659003589	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
365659003590	ATP binding site [chemical binding]; other site
365659003591	Mg2+ binding site [ion binding]; other site
365659003592	G-X-G motif; other site
365659003593	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
365659003594	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
365659003595	active site
365659003596	phosphorylation site [posttranslational modification]
365659003597	intermolecular recognition site; other site
365659003598	dimerization interface [polypeptide binding]; other site
365659003599	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
365659003600	DNA binding site [nucleotide binding]
365659003601	A/G-specific DNA glycosylase [DNA replication, recombination, and repair]; Region: MutY; COG1194
365659003602	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056
365659003603	minor groove reading motif; other site
365659003604	helix-hairpin-helix signature motif; other site
365659003605	substrate binding pocket [chemical binding]; other site
365659003606	active site
365659003607	DNA glycosylase (MutY in bacteria and hMYH in humans) is responsible for repairing misread  A*oxoG residues to C*G by removing the inappropriately paired adenine base from the DNA backbone. It belongs to the Nudix hydrolase superfamily and is important...; Region: DNA_Glycosylase_C; cd03431
365659003608	DNA binding and oxoG recognition site [nucleotide binding]
365659003609	phosphotransacetylase; Reviewed; Region: eutD; PRK09653
365659003610	Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564
365659003611	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cl09940
365659003612	RNA binding surface [nucleotide binding]; other site
365659003613	Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869
365659003614	active site
365659003615	inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK04885
365659003616	ATP-NAD kinase; Region: NAD_kinase; pfam01513
365659003617	Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399
365659003618	synthetase active site [active]
365659003619	NTP binding site [chemical binding]; other site
365659003620	metal binding site [ion binding]; metal-binding site
365659003621	Uncharacterized subgroup 1 of the CYTH-like superfamily; Region: CYTH-like_Pase_1; cd07762
365659003622	putative active site [active]
365659003623	putative metal binding residues [ion binding]; other site
365659003624	signature motif; other site
365659003625	putative triphosphate binding site [ion binding]; other site
365659003626	ribose-phosphate pyrophosphokinase; Provisional; Region: PRK02458
365659003627	N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793
365659003628	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
365659003629	active site
365659003630	Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104
365659003631	cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402
365659003632	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
365659003633	catalytic residue [active]
365659003634	Putative amino acid metabolism; Region: DUF1831; pfam08866
365659003635	AT-rich DNA-binding protein [General function prediction only]; Region: COG2344
365659003636	Putative DNA-binding protein N-terminus; Region: Put_DNA-bind_N; pfam06971
365659003637	CoA binding domain; Region: CoA_binding; pfam02629
365659003638	Predicted glutamine amidotransferases [General function prediction only]; Region: COG2071
365659003639	Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_2; cd01745
365659003640	catalytic triad [active]
365659003641	hypothetical protein; Reviewed; Region: PRK00024
365659003642	Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071
365659003643	MPN+ (JAMM) motif; other site
365659003644	Zinc-binding site [ion binding]; other site
365659003645	ATP-dependent DNA helicase PcrA; Region: pcrA; TIGR01073
365659003646	Part of AAA domain; Region: AAA_19; pfam13245
365659003647	Family description; Region: UvrD_C_2; pfam13538
365659003648	formate--tetrahydrofolate ligase; Provisional; Region: PRK13505
365659003649	Formyltetrahydrofolate synthetase (FTHFS) catalyzes the ATP-dependent activation of formate ion via its addition to the N10 position of tetrahydrofolate. FTHFS is a highly expressed key enzyme in both the Wood-Ljungdahl pathway of autotrophic CO2...; Region: FTHFS; cd00477
365659003650	Potassium binding sites [ion binding]; other site
365659003651	Cesium cation binding sites [ion binding]; other site
365659003652	phosphopantothenate--cysteine ligase; Validated; Region: PRK06732
365659003653	phosphopantothenoylcysteine decarboxylase; Validated; Region: PRK07313
365659003654	Flavoprotein; Region: Flavoprotein; pfam02441
365659003655	Predicted membrane protein [Function unknown]; Region: COG4684
365659003656	Predicted small molecule binding protein (contains 3H domain) [General function prediction only]; Region: COG1827
365659003657	HTH domain; Region: HTH_11; pfam08279
365659003658	3H domain; Region: 3H; pfam02829
365659003659	MutT homolog-1 (MTH1) is a member of the Nudix hydrolase superfamily. MTH1, the mammalian counterpart of MutT, hydrolyzes oxidized purine nucleoside triphosphates, such as 8-oxo-dGTP and 2-hydroxy-ATP, to monophosphates, thereby preventing the...; Region: MTH1; cd03427
365659003660	putative active site [active]
365659003661	nucleotide binding site [chemical binding]; other site
365659003662	nudix motif; other site
365659003663	putative metal binding site [ion binding]; other site
365659003664	Acetyltransferases [General function prediction only]; Region: RimI; COG0456
365659003665	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
365659003666	Coenzyme A binding pocket [chemical binding]; other site
365659003667	Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670
365659003668	excinuclease ABC subunit B; Provisional; Region: PRK05298
365659003669	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
365659003670	ATP binding site [chemical binding]; other site
365659003671	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
365659003672	nucleotide binding region [chemical binding]; other site
365659003673	ATP-binding site [chemical binding]; other site
365659003674	Ultra-violet resistance protein B; Region: UvrB; pfam12344
365659003675	UvrB/uvrC motif; Region: UVR; pfam02151
365659003676	CAAX protease self-immunity; Region: Abi; pfam02517
365659003677	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
365659003678	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
365659003679	substrate binding pocket [chemical binding]; other site
365659003680	membrane-bound complex binding site; other site
365659003681	hinge residues; other site
365659003682	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
365659003683	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
365659003684	substrate binding pocket [chemical binding]; other site
365659003685	membrane-bound complex binding site; other site
365659003686	hinge residues; other site
365659003687	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
365659003688	dimer interface [polypeptide binding]; other site
365659003689	conserved gate region; other site
365659003690	putative PBP binding loops; other site
365659003691	ABC-ATPase subunit interface; other site
365659003692	ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126
365659003693	ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262
365659003694	Walker A/P-loop; other site
365659003695	ATP binding site [chemical binding]; other site
365659003696	Q-loop/lid; other site
365659003697	ABC transporter signature motif; other site
365659003698	Walker B; other site
365659003699	D-loop; other site
365659003700	H-loop/switch region; other site
365659003701	glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722
365659003702	Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479
365659003703	Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781
365659003704	signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416
365659003705	SRP54-type protein, helical bundle domain; Region: SRP54_N; pfam02881
365659003706	The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115
365659003707	P loop; other site
365659003708	GTP binding site [chemical binding]; other site
365659003709	sugar phosphate phosphatase; Provisional; Region: PRK10513
365659003710	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
365659003711	motif II; other site
365659003712	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
365659003713	Predicted hydrolases of the HAD superfamily [General function prediction only]; Region: Cof; COG0561
365659003714	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
365659003715	active site
365659003716	motif I; other site
365659003717	motif II; other site
365659003718	haloacid dehalogenase-like hydrolase; Region: HAD; cl17202
365659003719	Chromosome segregation ATPases [Cell division and chromosome partitioning]; Region: Smc; COG1196
365659003720	ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278
365659003721	Walker A/P-loop; other site
365659003722	ATP binding site [chemical binding]; other site
365659003723	Q-loop/lid; other site
365659003724	putative uroporphyrinogen III C-methyltransferase; Provisional; Region: PRK10920
365659003725	SMC proteins Flexible Hinge Domain; Region: SMC_hinge; smart00968
365659003726	ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278
365659003727	ABC transporter signature motif; other site
365659003728	Walker B; other site
365659003729	D-loop; other site
365659003730	H-loop/switch region; other site
365659003731	ribonuclease III; Reviewed; Region: rnc; PRK00102
365659003732	RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593
365659003733	dimerization interface [polypeptide binding]; other site
365659003734	active site
365659003735	metal binding site [ion binding]; metal-binding site
365659003736	Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048
365659003737	dsRNA binding site [nucleotide binding]; other site
365659003738	guanosine 5'-monophosphate oxidoreductase; Provisional; Region: PRK05458
365659003739	IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381
365659003740	active site
365659003741	Telomere recombination; Region: Sua5_yciO_yrdC; cl00305
365659003742	isopropylmalate isomerase small subunit; Provisional; Region: leuD; PRK01641
365659003743	Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577
365659003744	substrate binding site [chemical binding]; other site
365659003745	3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402
365659003746	3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583
365659003747	substrate binding site [chemical binding]; other site
365659003748	ligand binding site [chemical binding]; other site
365659003749	Predicted membrane protein [Function unknown]; Region: COG3326
365659003750	3-isopropylmalate dehydrogenase; Provisional; Region: PRK00772
365659003751	tartrate dehydrogenase; Region: TTC; TIGR02089
365659003752	2-isopropylmalate synthase; Validated; Region: PRK00915
365659003753	2-isopropylmalate synthase (IPMS), N-terminal catalytic TIM barrel domain; Region: DRE_TIM_IPMS; cd07940
365659003754	active site
365659003755	catalytic residues [active]
365659003756	metal binding site [ion binding]; metal-binding site
365659003757	LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; pfam08502
365659003758	Uncharacterized protein conserved in bacteria [Function unknown]; Region: MmcQ; COG2315
365659003759	Uncharacterized protein involved in copper resistance [Inorganic ion transport and metabolism]; Region: CutC; COG3142
365659003760	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2832
365659003761	DNA topoisomerase I; Validated; Region: PRK05582
365659003762	TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I.   Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363
365659003763	active site
365659003764	interdomain interaction site; other site
365659003765	putative metal-binding site [ion binding]; other site
365659003766	nucleotide binding site [chemical binding]; other site
365659003767	DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186
365659003768	domain I; other site
365659003769	DNA binding groove [nucleotide binding]
365659003770	phosphate binding site [ion binding]; other site
365659003771	domain II; other site
365659003772	domain III; other site
365659003773	nucleotide binding site [chemical binding]; other site
365659003774	catalytic site [active]
365659003775	domain IV; other site
365659003776	Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396
365659003777	Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396
365659003778	DNA recombination-mediator protein A; Region: DNA_processg_A; pfam02481
365659003779	DNA protecting protein DprA; Region: dprA; TIGR00732
365659003780	Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208
365659003781	Phosphocholine cytidylyltransferases catalyze the synthesis of CDP-choline; Region: PC_cytidylyltransferase; cd02523
365659003782	active site
365659003783	metal-binding site
365659003784	Phosphotransferase enzyme family; Region: APH; pfam01636
365659003785	Choline Kinase (ChoK). The ChoK subfamily is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs), RIO kinases, actin-fragmin kinase (AFK), and...; Region: ChoK; cd05151
365659003786	active site
365659003787	substrate binding site [chemical binding]; other site
365659003788	ATP binding site [chemical binding]; other site
365659003789	dimer interface [polypeptide binding]; other site
365659003790	ribitol-5-phosphate dehydrogenase; Region: ribitol-5-phosphate_DH; cd08237
365659003791	Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063
365659003792	putative NAD(P) binding site [chemical binding]; other site
365659003793	putative catalytic Zn binding site [ion binding]; other site
365659003794	CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516
365659003795	substrate binding site; other site
365659003796	dimer interface; other site
365659003797	Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244
365659003798	Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326
365659003799	LPS biosynthesis protein [Cell envelope biogenesis, outer membrane]; Region: COG3475
365659003800	LPS biosynthesis protein [Cell envelope biogenesis, outer membrane]; Region: COG3475
365659003801	Mn2+ and Fe2+ transporters of the NRAMP family [Inorganic ion transport and metabolism]; Region: MntH; cl15845
365659003802	Natural resistance-associated macrophage protein; Region: Nramp; pfam01566
365659003803	carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294
365659003804	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
365659003805	Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786
365659003806	Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787
365659003807	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
365659003808	ATP-grasp domain; Region: ATP-grasp_4; cl17255
365659003809	Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424
365659003810	IMP binding site; other site
365659003811	dimer interface [polypeptide binding]; other site
365659003812	interdomain contacts; other site
365659003813	partial ornithine binding site; other site
365659003814	carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564
365659003815	Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; smart01097
365659003816	Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744
365659003817	catalytic site [active]
365659003818	subunit interface [polypeptide binding]; other site
365659003819	aspartate carbamoyltransferase catalytic subunit; Provisional; Region: pyrB; PRK00856
365659003820	Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729
365659003821	Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185
365659003822	Pyrimidine operon attenuation protein/uracil phosphoribosyltransferase [Nucleotide transport and metabolism]; Region: PyrR; COG2065
365659003823	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
365659003824	active site
365659003825	Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177
365659003826	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056
365659003827	minor groove reading motif; other site
365659003828	helix-hairpin-helix signature motif; other site
365659003829	substrate binding pocket [chemical binding]; other site
365659003830	active site
365659003831	Predicted metal-binding, possibly nucleic acid-binding protein [General function prediction only]; Region: COG1399
365659003832	ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488
365659003833	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
365659003834	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
365659003835	heat shock protein HtpX; Provisional; Region: PRK04897
365659003836	Uncharacterized conserved protein [Function unknown]; Region: LemA; COG1704
365659003837	Predicted S-adenosylmethionine-dependent methyltransferase involved in bacterial cell division [Cell envelope biogenesis, outer membrane]; Region: GidB; COG0357
365659003838	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
365659003839	S-adenosylmethionine binding site [chemical binding]; other site
365659003840	uracil transporter; Provisional; Region: PRK10720
365659003841	Restriction endonuclease [Defense mechanisms]; Region: COG3587
365659003842	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
365659003843	ATP binding site [chemical binding]; other site
365659003844	Adenine specific DNA methylase Mod [DNA replication, recombination, and repair]; Region: COG2189
365659003845	DNA methylase; Region: N6_N4_Mtase; cl17433
365659003846	DNA methylase; Region: N6_N4_Mtase; pfam01555
365659003847	DNA methylase; Region: N6_N4_Mtase; cl17433
365659003848	Domain of unknown function (DUF4391); Region: DUF4391; pfam14335
365659003849	N-terminal putative catalytic domain of uncharacterized prokaryotic and archeal HKD family nucleases fused to a DEAD/DEAH box helicase domain; Region: PLDc_N_DEXD_c; cd10311
365659003850	putative active site [active]
365659003851	catalytic site [active]
365659003852	Superfamily II DNA/RNA helicases, SNF2 family [Transcription / DNA replication, recombination, and repair]; Region: HepA; COG0553
365659003853	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
365659003854	ATP binding site [chemical binding]; other site
365659003855	putative Mg++ binding site [ion binding]; other site
365659003856	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
365659003857	nucleotide binding region [chemical binding]; other site
365659003858	ATP-binding site [chemical binding]; other site
365659003859	signal recognition particle protein; Provisional; Region: PRK10867
365659003860	SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963
365659003861	The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115
365659003862	P loop; other site
365659003863	GTP binding site [chemical binding]; other site
365659003864	Signal peptide binding domain; Region: SRP_SPB; pfam02978
365659003865	Putative helix-turn-helix protein, YlxM / p13 like; Region: UPF0122; pfam04297
365659003866	Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569
365659003867	Domain of unknown function (DUF1934); Region: DUF1934; pfam09148
365659003868	HD superfamily phosphohydrolases [General function prediction only]; Region: COG1078
365659003869	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
365659003870	Zn2+ binding site [ion binding]; other site
365659003871	Mg2+ binding site [ion binding]; other site
365659003872	sugar phosphate phosphatase; Provisional; Region: PRK10513
365659003873	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
365659003874	active site
365659003875	motif I; other site
365659003876	motif II; other site
365659003877	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
365659003878	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
365659003879	H+ Antiporter protein; Region: 2A0121; TIGR00900
365659003880	putative substrate translocation pore; other site
365659003881	CYTH-like (also known as triphosphate tunnel metalloenzyme (TTM)-like) Phosphatases; Region: CYTH-like_Pase; cl11964
365659003882	putative active site; other site
365659003883	putative metal binding residues [ion binding]; other site
365659003884	signature motif; other site
365659003885	putative triphosphate binding site [ion binding]; other site
365659003886	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
365659003887	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
365659003888	non-specific DNA binding site [nucleotide binding]; other site
365659003889	salt bridge; other site
365659003890	sequence-specific DNA binding site [nucleotide binding]; other site
365659003891	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
365659003892	DNA binding site [nucleotide binding]
365659003893	active site
365659003894	Int/Topo IB signature motif; other site
365659003895	Protein of unknown function DUF86; Region: DUF86; cl01031
365659003896	Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403
365659003897	active site
365659003898	NTP binding site [chemical binding]; other site
365659003899	metal binding triad [ion binding]; metal-binding site
365659003900	antibiotic binding site [chemical binding]; other site
365659003901	RelB antitoxin; Region: RelB; cl01171
365659003902	50S ribosomal protein L19; Provisional; Region: rplS; PRK05338
365659003903	camphor resistance protein CrcB; Provisional; Region: PRK14229
365659003904	camphor resistance protein CrcB; Provisional; Region: PRK14221
365659003905	hypothetical protein; Provisional; Region: PRK07248
365659003906	flavodoxin; Validated; Region: PRK07308
365659003907	Exopolyphosphatase-related proteins [General function prediction only]; Region: COG0618
365659003908	DHH family; Region: DHH; pfam01368
365659003909	50S ribosomal protein L31 type B; Reviewed; Region: rpmE2; PRK01678
365659003910	RelB antitoxin; Region: RelB; cl01171
365659003911	Plasmid stabilisation system protein; Region: Plasmid_stabil; pfam05016
365659003912	mttA/Hcf106 family; Region: MttA_Hcf106; cl00788
365659003913	Sec-independent protein secretion pathway component TatC [Intracellular trafficking and secretion]; Region: TatC; COG0805
365659003914	High-affinity Fe2+/Pb2+ permease [Inorganic ion transport and metabolism]; Region: FTR1; COG0672
365659003915	Predicted iron-dependent peroxidase [Inorganic ion transport and metabolism]; Region: COG2837
365659003916	Imelysin; Region: Peptidase_M75; pfam09375
365659003917	multiple promoter invertase; Provisional; Region: mpi; PRK13413
365659003918	Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768
365659003919	catalytic residues [active]
365659003920	catalytic nucleophile [active]
365659003921	Presynaptic Site I dimer interface [polypeptide binding]; other site
365659003922	Synaptic Antiparallel dimer interface [polypeptide binding]; other site
365659003923	Synaptic Flat tetramer interface [polypeptide binding]; other site
365659003924	Synaptic Site I dimer interface [polypeptide binding]; other site
365659003925	DNA binding site [nucleotide binding]
365659003926	FOG: Glucan-binding domain (YG repeat) [General function prediction only]; Region: COG5263
365659003927	Putative cell wall binding repeat; Region: CW_binding_1; pfam01473
365659003928	hypothetical protein; Validated; Region: PRK00153
365659003929	Membrane domain of glycerophosphoryl diester phosphodiesterase; Region: GPDPase_memb; cl01974
365659003930	Glycerophosphodiester phosphodiesterase domain of uncharacterized bacterial glycerophosphodiester phosphodiesterases; Region: GDPD_memb_like; cd08579
365659003931	Glycerophosphoryl diester phosphodiesterase family; Region: GDPD; pfam03009
365659003932	putative active site [active]
365659003933	catalytic site [active]
365659003934	putative metal binding site [ion binding]; other site
365659003935	DNA polymerase III, epsilon subunit and related 3'-5' exonucleases [DNA replication, recombination, and repair]; Region: DnaQ; COG0847
365659003936	DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127
365659003937	active site
365659003938	catalytic site [active]
365659003939	substrate binding site [chemical binding]; other site
365659003940	MarR family; Region: MarR_2; cl17246
365659003941	5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Validated; Region: PRK05584
365659003942	5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Region: MTA/SAH-Nsdase; TIGR01704
365659003943	ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424
365659003944	dimer interface [polypeptide binding]; other site
365659003945	ADP-ribose binding site [chemical binding]; other site
365659003946	active site
365659003947	nudix motif; other site
365659003948	metal binding site [ion binding]; metal-binding site
365659003949	bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase; Provisional; Region: glmU; PRK14354
365659003950	N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540
365659003951	Substrate binding site; other site
365659003952	Mg++ binding site; other site
365659003953	N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353
365659003954	active site
365659003955	substrate binding site [chemical binding]; other site
365659003956	CoA binding site [chemical binding]; other site
365659003957	Lyzozyme M1 (1,4-beta-N-acetylmuramidase) [Cell envelope biogenesis, outer membrane]; Region: Acm; COG3757
365659003958	PlyB is a bacteriophage endolysin that displays potent lytic activity toward Bacillus anthracis.  PlyB has an N-terminal glycosyl hydrolase family 25 (GH25) catalytic domain and a C-terminal bacterial SH3-like domain, SH3b.  Both domains are required for...; Region: GH25_PlyB-like; cd06523
365659003959	active site
365659003960	Predicted membrane protein [Function unknown]; Region: COG2035
365659003961	This CD includes cysteinyl-tRNA(Pro) deacylases from Haemophilus influenzae and Escherichia coli and other related bacterial proteins. These trans-acting, single-domain proteins are homologs of ProX and also the cis-acting prolyl-tRNA synthetase (ProRS)...; Region: YbaK_deacylase; cd00002
365659003962	putative deacylase active site [active]
365659003963	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
365659003964	catalytic core [active]
365659003965	lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484
365659003966	LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322
365659003967	dimer interface [polypeptide binding]; other site
365659003968	putative anticodon binding site; other site
365659003969	Lys_tRNA synthetase (LysRS) class II core domain. Class II LysRS is a dimer which attaches a lysine to the 3' OH group of ribose of the appropriate tRNA. Its assignment to class II aaRS is based upon its structure and the presence of three...; Region: LysRS_core; cd00775
365659003970	motif 1; other site
365659003971	active site
365659003972	motif 2; other site
365659003973	motif 3; other site
365659003974	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
365659003975	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
365659003976	substrate binding pocket [chemical binding]; other site
365659003977	membrane-bound complex binding site; other site
365659003978	hinge residues; other site
365659003979	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
365659003980	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
365659003981	Walker A/P-loop; other site
365659003982	ATP binding site [chemical binding]; other site
365659003983	Q-loop/lid; other site
365659003984	ABC transporter signature motif; other site
365659003985	Walker B; other site
365659003986	D-loop; other site
365659003987	H-loop/switch region; other site
365659003988	ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215
365659003989	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
365659003990	dimer interface [polypeptide binding]; other site
365659003991	conserved gate region; other site
365659003992	putative PBP binding loops; other site
365659003993	ABC-ATPase subunit interface; other site
365659003994	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
365659003995	binding surface
365659003996	TPR motif; other site
365659003997	Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628
365659003998	Domain of unknown function DUF20; Region: UPF0118; pfam01594
365659003999	The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504
365659004000	peptide binding site [polypeptide binding]; other site
365659004001	Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496
365659004002	Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826
365659004003	Helix-turn-helix domain; Region: HTH_38; pfam13936
365659004004	Integrase core domain; Region: rve; pfam00665
365659004005	3-carboxymuconate cyclase [Carbohydrate transport and metabolism]; Region: COG2706
365659004006	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464
365659004007	Transposase; Region: DDE_Tnp_ISL3; pfam01610
365659004008	Gram-positive signal peptide, YSIRK family; Region: YSIRK_signal; TIGR01168
365659004009	Domain of Unknown Function (DUF1542); Region: DUF1542; pfam07564
365659004010	Domain of Unknown Function (DUF1542); Region: DUF1542; pfam07564
365659004011	Heat shock protein 33 (Hsp33):  Cytosolic protein that acts as a molecular chaperone under oxidative conditions.  In normal (reducing) cytosolic conditions, four conserved Cys residues are coordinated by a Zn ion. Under oxidative stress (such as heat...; Region: Hsp33; cl00236
365659004012	F0F1 ATP synthase subunit epsilon; Validated; Region: atpC; PRK00571
365659004013	mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152
365659004014	gamma subunit interface [polypeptide binding]; other site
365659004015	epsilon subunit interface [polypeptide binding]; other site
365659004016	LBP interface [polypeptide binding]; other site
365659004017	F0F1 ATP synthase subunit beta; Validated; Region: PRK09280
365659004018	ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874
365659004019	F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133
365659004020	alpha subunit interaction interface [polypeptide binding]; other site
365659004021	Walker A motif; other site
365659004022	ATP binding site [chemical binding]; other site
365659004023	Walker B motif; other site
365659004024	inhibitor binding site; inhibition site
365659004025	ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306
365659004026	mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151
365659004027	core domain interface [polypeptide binding]; other site
365659004028	delta subunit interface [polypeptide binding]; other site
365659004029	epsilon subunit interface [polypeptide binding]; other site
365659004030	F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281
365659004031	ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874
365659004032	F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132
365659004033	beta subunit interaction interface [polypeptide binding]; other site
365659004034	Walker A motif; other site
365659004035	ATP binding site [chemical binding]; other site
365659004036	Walker B motif; other site
365659004037	ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306
365659004038	F0F1 ATP synthase subunit delta; Validated; Region: PRK05758
365659004039	ATP synthase delta (OSCP) subunit; Region: OSCP; pfam00213
365659004040	F0F1-type ATP synthase, subunit b [Energy production and conversion]; Region: AtpF; COG0711
365659004041	F0F1 ATP synthase subunit B; Validated; Region: PRK05759
365659004042	F0F1-type ATP synthase, subunit a [Energy production and conversion]; Region: AtpB; COG0356
365659004043	F0F1 ATP synthase subunit A; Validated; Region: PRK05815
365659004044	F0F1 ATP synthase subunit C; Provisional; Region: PRK13467
365659004045	Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826
365659004046	Peptidase family U32; Region: Peptidase_U32; pfam01136
365659004047	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632
365659004048	conjugative transposon Tn5801
365659004049	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
365659004050	AAA domain; Region: AAA_21; pfam13304
365659004051	Walker A/P-loop; other site
365659004052	ATP binding site [chemical binding]; other site
365659004053	Predicted ATP-dependent endonuclease of the OLD family [DNA replication, recombination, and repair]; Region: COG3593
365659004054	TOPRIM_OLD: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in bacterial and archaeal nucleases of the OLD (overcome lysogenization defect) family.  The bacteriophage P2 OLD protein, which has DNase as well as...; Region: TOPRIM_OLD; cd01026
365659004055	putative active site [active]
365659004056	putative metal-binding site [ion binding]; other site
365659004057	Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210
365659004058	Part of AAA domain; Region: AAA_19; pfam13245
365659004059	Family description; Region: UvrD_C_2; pfam13538
365659004060	Bacterial protein of unknown function (DUF961); Region: DUF961; pfam06125
365659004061	Bacterial protein of unknown function (DUF961); Region: DUF961; pfam06125
365659004062	FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580
365659004063	ATPases associated with a variety of cellular activities; Region: AAA; smart00382
365659004064	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
365659004065	non-specific DNA binding site [nucleotide binding]; other site
365659004066	salt bridge; other site
365659004067	sequence-specific DNA binding site [nucleotide binding]; other site
365659004068	Replication initiation factor; Region: Rep_trans; pfam02486
365659004069	Abortive infection C-terminus; Region: Abi_C; pfam14355
365659004070	Antirestriction protein (ArdA); Region: ArdA; pfam07275
365659004071	TcpE family; Region: TcpE; pfam12648
365659004072	AAA-like domain; Region: AAA_10; pfam12846
365659004073	Transmembrane amino acid transporter protein; Region: Aa_trans; cl17468
365659004074	Major Facilitator Superfamily; Region: MFS_1; pfam07690
365659004075	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
365659004076	N-acetyl-D-glucosamine binding site [chemical binding]; other site
365659004077	catalytic residue [active]
365659004078	Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791
365659004079	NlpC/P60 family; Region: NLPC_P60; pfam00877
365659004080	Conjugative transposon protein TcpC; Region: TpcC; pfam12642
365659004081	Translation elongation factors (GTPases) [Translation, ribosomal structure and biogenesis]; Region: FusA; COG0480
365659004082	Tet(M)-like family includes Tet(M), Tet(O), Tet(W), and OtrA, containing tetracycline resistant proteins; Region: TetM_like; cd04168
365659004083	G1 box; other site
365659004084	putative GEF interaction site [polypeptide binding]; other site
365659004085	GTP/Mg2+ binding site [chemical binding]; other site
365659004086	Switch I region; other site
365659004087	G2 box; other site
365659004088	G3 box; other site
365659004089	Switch II region; other site
365659004090	G4 box; other site
365659004091	G5 box; other site
365659004092	Tet_II: This subfamily represents domain II of ribosomal protection proteins Tet(M) and Tet(O). This domain has homology to domain II of the elongation factors EF-G and EF-2. Tet(M) and Tet(O) catalyze the release of tetracycline (Tc) from the ribosome...; Region: Tet_II; cd03690
365659004093	EF-G_domain IV_RPP domain is a part of bacterial ribosomal protected proteins (RPP) family. RPPs such as tetracycline resistance proteins Tet(M) and Tet(O) mediate tetracycline resistance in both gram-positive and -negative species. Tetracyclines inhibit...; Region: Tet_like_IV; cd01684
365659004094	Tet_C: C-terminus of ribosomal protection proteins Tet(M) and Tet(O). This domain has homology to the C terminal domains of the elongation factors EF-G and EF-2. Tet(M) and Tet(O) catalyze the release of tetracycline (Tc) from the ribosome in a...; Region: Tet_C; cd03711
365659004095	Cysteine-rich KTR; Region: Cys_rich_KTR; pfam14205
365659004096	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
365659004097	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
365659004098	non-specific DNA binding site [nucleotide binding]; other site
365659004099	salt bridge; other site
365659004100	sequence-specific DNA binding site [nucleotide binding]; other site
365659004101	RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937
365659004102	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
365659004103	DNA binding residues [nucleotide binding]
365659004104	Helix-turn-helix domain; Region: HTH_16; pfam12645
365659004105	Domain of unknown function (DUF3173); Region: DUF3173; pfam11372
365659004106	Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582
365659004107	phiLC3 phage and phage-related integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes various bacterial (mainly gram positive) and phage integrases, including those similar to Lactococcus...; Region: INT_phiLC3_C; cd01189
365659004108	Int/Topo IB signature motif; other site
365659004109	GMP synthase; Reviewed; Region: guaA; PRK00074
365659004110	Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742
365659004111	AMP/PPi binding site [chemical binding]; other site
365659004112	candidate oxyanion hole; other site
365659004113	catalytic triad [active]
365659004114	potential glutamine specificity residues [chemical binding]; other site
365659004115	The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997
365659004116	ATP Binding subdomain [chemical binding]; other site
365659004117	Dimerization subdomain; other site
365659004118	Transcriptional regulators [Transcription]; Region: PhnF; COG2188
365659004119	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
365659004120	DNA-binding site [nucleotide binding]; DNA binding site
365659004121	UTRA domain; Region: UTRA; pfam07702
365659004122	EamA-like transporter family; Region: EamA; pfam00892
365659004123	Beta-lactamase; Region: Beta-lactamase; pfam00144
365659004124	Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680
365659004125	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632
365659004126	Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cd00333
365659004127	amphipathic channel; other site
365659004128	Asn-Pro-Ala signature motifs; other site
365659004129	FOG: Glucan-binding domain (YG repeat) [General function prediction only]; Region: COG5263
365659004130	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
365659004131	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
365659004132	non-specific DNA binding site [nucleotide binding]; other site
365659004133	salt bridge; other site
365659004134	sequence-specific DNA binding site [nucleotide binding]; other site
365659004135	ATP-grasp domain; Region: ATP-grasp_4; pfam13535
365659004136	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4947
365659004137	Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819
365659004138	Putative esterase; Region: Esterase; pfam00756
365659004139	thiamine biosynthesis protein ThiI; Provisional; Region: PRK01565
365659004140	THUMP domain of thiamine biosynthesis protein ThiI; Region: THUMP_ThiI; cd11716
365659004141	ThiI is required for thiazole synthesis in the thiamine biosynthesis pathway. It belongs to the Adenosine Nucleotide Hydrolysis suoerfamily and predicted to bind to Adenosine nucleotide; Region: ThiI; cd01712
365659004142	Ligand Binding Site [chemical binding]; other site
365659004143	Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104
365659004144	cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402
365659004145	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
365659004146	catalytic residue [active]
365659004147	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
365659004148	DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674
365659004149	FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580
365659004150	Ftsk gamma domain; Region: Ftsk_gamma; pfam09397
365659004151	PTS system 2-O-a-mannosyl-D-glycerate specific transporter subunit IIABC; Provisional; Region: PRK09765
365659004152	PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211
365659004153	active site
365659004154	phosphorylation site [posttranslational modification]
365659004155	PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569
365659004156	active site
365659004157	P-loop; other site
365659004158	phosphorylation site [posttranslational modification]
365659004159	Phosphotransferase system, fructose-specific IIC component [Carbohydrate transport and metabolism]; Region: FruA; COG1299
365659004160	Fructose-1-phosphate kinase and related fructose-6-phosphate kinase (PfkB) [Carbohydrate transport and metabolism]; Region: FruK; COG1105
365659004161	1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164
365659004162	putative substrate binding site [chemical binding]; other site
365659004163	putative ATP binding site [chemical binding]; other site
365659004164	Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349
365659004165	helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420
365659004166	DeoR C terminal sensor domain; Region: DeoRC; pfam00455
365659004167	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3666
365659004168	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
365659004169	Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751
365659004170	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
365659004171	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963
365659004172	Helix-turn-helix domain; Region: HTH_28; pfam13518
365659004173	Transposase; Region: HTH_Tnp_1; cl17663
365659004174	putative transposase OrfB; Reviewed; Region: PHA02517
365659004175	HTH-like domain; Region: HTH_21; pfam13276
365659004176	Integrase core domain; Region: rve; pfam00665
365659004177	Integrase core domain; Region: rve_2; pfam13333
365659004178	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
365659004179	non-specific DNA binding site [nucleotide binding]; other site
365659004180	salt bridge; other site
365659004181	sequence-specific DNA binding site [nucleotide binding]; other site
365659004182	Predicted transcriptional regulator [Transcription]; Region: COG2932
365659004183	Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529
365659004184	Catalytic site [active]
365659004185	Uncharacterized conserved protein [Function unknown]; Region: COG4127
365659004186	COG2337, MazF, growth inhibitor
365659004187	COG2337, MazF, growth inhibitor
365659004188	Domain of Unknown Function with PDB structure (DUF3862); Region: DUF3862; pfam12978
365659004189	Domain of Unknown Function with PDB structure (DUF3862); Region: DUF3862; pfam12978
365659004190	cd00801, bacteriophage P4-like integrase
365659004191	NnaC (CMP-NeuNAc synthetase) _like subfamily of SGNH_hydrolases, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its...; Region: NnaC_like; cd01841
365659004192	active site
365659004193	catalytic triad [active]
365659004194	oxyanion hole [active]
365659004195	Predicted hydrolases of the HAD superfamily [General function prediction only]; Region: Cof; COG0561
365659004196	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
365659004197	active site
365659004198	motif I; other site
365659004199	motif II; other site
365659004200	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
365659004201	Bacterial capsule synthesis protein PGA_cap; Region: PGA_cap; smart00854
365659004202	CapA and related proteins, metallophosphatase domain; Region: MPP_CapA; cd07381
365659004203	putative active site [active]
365659004204	putative metal binding site [ion binding]; other site
365659004205	Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487
365659004206	active site
365659004207	catalytic residues [active]
365659004208	metal binding site [ion binding]; metal-binding site
365659004209	rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566
365659004210	RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032
365659004211	SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588
365659004212	thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292
365659004213	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
365659004214	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
365659004215	Protein of unknown function (DUF4059); Region: DUF4059; pfam13268
365659004216	ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126
365659004217	ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262
365659004218	Walker A/P-loop; other site
365659004219	ATP binding site [chemical binding]; other site
365659004220	Q-loop/lid; other site
365659004221	ABC transporter signature motif; other site
365659004222	Walker B; other site
365659004223	D-loop; other site
365659004224	H-loop/switch region; other site
365659004225	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427
365659004226	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
365659004227	ABC-ATPase subunit interface; other site
365659004228	putative PBP binding loops; other site
365659004229	Arsenate Reductase (ArsC) family, unknown subfamily; uncharacterized proteins containing a CXXC motif with similarity to thioredoxin (TRX)-fold arsenic reductases, ArsC. Proteins containing a redox active CXXC motif like TRX and glutaredoxin (GRX)...; Region: ArsC_like; cd03036
365659004230	ArsC family; Region: ArsC; pfam03960
365659004231	putative ArsC-like catalytic residues; other site
365659004232	putative TRX-like catalytic residues [active]
365659004233	Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350
365659004234	The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445
365659004235	DNA binding site [nucleotide binding]
365659004236	active site
365659004237	Domain of unknown function (DUF1836); Region: DUF1836; pfam08876
365659004238	Predicted membrane protein, hemolysin III homolog [General function prediction only]; Region: COG1272
365659004239	channel protein, hemolysin III family; Region: hlyIII; TIGR01065
365659004240	Glutamine Amidotransferase (GATase_I) involved in pyridoxine biosynthesis; Region: GATase1_PB; cd01749
365659004241	predicted active site [active]
365659004242	catalytic triad [active]
365659004243	pyridoxal 5'-phosphate synthase, synthase subunit Pdx1; Region: TIGR00343
365659004244	PdxS is a subunit of the pyridoxal 5'-phosphate (PLP) synthase, an important enzyme in deoxyxylulose 5-phosphate (DXP)-independent pathway for de novo biosynthesis of PLP,  present in some eubacteria, in archaea, fungi, plants, plasmodia, and some...; Region: pdxS; cd04727
365659004245	active site
365659004246	multimer interface [polypeptide binding]; other site
365659004247	coenzyme A disulfide reductase; Reviewed; Region: PRK09564
365659004248	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
365659004249	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
365659004250	Membrane-associated lipoprotein involved in thiamine biosynthesis [Coenzyme metabolism]; Region: ApbE; COG1477
365659004251	ApbE family; Region: ApbE; pfam02424
365659004252	Predicted flavoprotein [General function prediction only]; Region: COG0431
365659004253	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
365659004254	Predicted flavoprotein [General function prediction only]; Region: COG0431
365659004255	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
365659004256	PAS domain; Region: PAS_10; pfam13596
365659004257	hypothetical protein; Provisional; Region: PRK02539
365659004258	glycyl-tRNA synthetase subunit beta; Validated; Region: glyS; PRK01233
365659004259	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; smart00471
365659004260	DALR anticodon binding domain; Region: DALR_1; pfam05746
365659004261	Class II Glycyl-tRNA synthetase (GlyRS) alpha subunit core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes and in arabidopsis. It is responsible for the...; Region: GlyRS_alpha_core; cd00733
365659004262	dimer interface [polypeptide binding]; other site
365659004263	motif 1; other site
365659004264	active site
365659004265	motif 2; other site
365659004266	motif 3; other site
365659004267	Peptidase S8 family domain in Streptococcal C5a peptidases; Region: Peptidases_S8_C5a_Peptidase; cd07475
365659004268	putative active site [active]
365659004269	catalytic triad [active]
365659004270	PA_C5a_like: Protease-associated domain containing proteins like Streptococcus pyogenes C5a peptidase. This group contains various PA domain-containing proteins similar to S. pyogenes C5a, including, i) Vpr, a minor extracellular serine protease from...; Region: PA_C5a_like; cd02133
365659004271	PA/protease domain interface [polypeptide binding]; other site
365659004272	putative integrin binding motif; other site
365659004273	Peptidase S8 family domain in Streptococcal C5a peptidases; Region: Peptidases_S8_C5a_Peptidase; cd07475
365659004274	Fn3-like domain (DUF1034); Region: DUF1034; pfam06280
365659004275	Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726
365659004276	Catalytic NodB homology domain of Streptococcus pneumoniae peptidoglycan deacetylase PgdA, Bacillus subtilis BsYjeA protein, and their bacterial homologs; Region: CE4_SpPgdA_BsYjeA_like; cd10947
365659004277	NodB motif; other site
365659004278	active site
365659004279	catalytic site [active]
365659004280	Zn binding site [ion binding]; other site
365659004281	S-adenosylmethionine synthetase; Validated; Region: PRK05250
365659004282	S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438
365659004283	S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772
365659004284	S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773
365659004285	DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker  B motif; Region: DEADc; cd00268
365659004286	DEAD-like helicases superfamily; Region: DEXDc; smart00487
365659004287	ATP binding site [chemical binding]; other site
365659004288	Mg++ binding site [ion binding]; other site
365659004289	motif III; other site
365659004290	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
365659004291	nucleotide binding region [chemical binding]; other site
365659004292	ATP-binding site [chemical binding]; other site
365659004293	Streptococcus agalactiae RgfB, part of a putative two component signal transduction system, and related proteins; Region: RgfB-like; cd09079
365659004294	putative catalytic site [active]
365659004295	putative metal binding site [ion binding]; other site
365659004296	putative phosphate binding site [ion binding]; other site
365659004297	Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263
365659004298	PTS system, IIBC component; Region: PTS-II-BC-unk1; TIGR02003
365659004299	PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212
365659004300	active site turn [active]
365659004301	phosphorylation site [posttranslational modification]
365659004302	Phosphotransferase system IIA components [Carbohydrate transport and metabolism]; Region: NagE; COG2190
365659004303	HPr interaction site; other site
365659004304	glycerol kinase (GK) interaction site [polypeptide binding]; other site
365659004305	active site
365659004306	phosphorylation site [posttranslational modification]
365659004307	Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826
365659004308	Helix-turn-helix domain; Region: HTH_38; pfam13936
365659004309	Integrase core domain; Region: rve; pfam00665
365659004310	Cell division protein [Cell division and chromosome partitioning]; Region: FtsX; COG2177
365659004311	cell division ABC transporter subunit FtsX; Provisional; Region: ftsX; PRK11026
365659004312	Predicted ATPase involved in cell division [Cell division and chromosome partitioning]; Region: FtsE; COG2884
365659004313	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
365659004314	Walker A/P-loop; other site
365659004315	ATP binding site [chemical binding]; other site
365659004316	Q-loop/lid; other site
365659004317	ABC transporter signature motif; other site
365659004318	Walker B; other site
365659004319	D-loop; other site
365659004320	H-loop/switch region; other site
365659004321	PCRF domain; Region: PCRF; pfam03462
365659004322	Protein chain release factor B [Translation, ribosomal structure and biogenesis]; Region: PrfB; COG1186
365659004323	RF-1 domain; Region: RF-1; pfam00472
365659004324	Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826
365659004325	Helix-turn-helix domain; Region: HTH_38; pfam13936
365659004326	Integrase core domain; Region: rve; pfam00665
365659004327	FOG: CBS domain [General function prediction only]; Region: COG0517
365659004328	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in  the acetoin utilization proteins in bacteria. Acetoin is a product of fermentative metabolism in many prokaryotic and eukaryotic microorganisms.  They produce...; Region: CBS_pair_ACT_assoc2; cd04585
365659004329	ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cd02116
365659004330	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410
365659004331	ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224
365659004332	Walker A/P-loop; other site
365659004333	ATP binding site [chemical binding]; other site
365659004334	Q-loop/lid; other site
365659004335	ABC transporter signature motif; other site
365659004336	Walker B; other site
365659004337	D-loop; other site
365659004338	H-loop/switch region; other site
365659004339	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411
365659004340	ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219
365659004341	Walker A/P-loop; other site
365659004342	ATP binding site [chemical binding]; other site
365659004343	Q-loop/lid; other site
365659004344	ABC transporter signature motif; other site
365659004345	Walker B; other site
365659004346	D-loop; other site
365659004347	H-loop/switch region; other site
365659004348	ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177
365659004349	Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581
365659004350	TM-ABC transporter signature motif; other site
365659004351	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
365659004352	Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582
365659004353	TM-ABC transporter signature motif; other site
365659004354	ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683
365659004355	Type I periplasmic ligand-binding domain of uncharacterized ABC (Atpase Binding Cassette)-type active transport systems that are predicted to be involved in uptake of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_ligand_binding_like_12; cd06347
365659004356	putative ligand binding site [chemical binding]; other site
365659004357	hypothetical protein; Provisional; Region: PRK02302
365659004358	Clp protease; Region: CLP_protease; pfam00574
365659004359	Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017
365659004360	oligomer interface [polypeptide binding]; other site
365659004361	active site residues [active]
365659004362	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
365659004363	active site
365659004364	Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826
365659004365	Helix-turn-helix domain; Region: HTH_38; pfam13936
365659004366	Integrase core domain; Region: rve; pfam00665
365659004367	Deoxycytidylate deaminase domain. Deoxycytidylate deaminase catalyzes the deamination of dCMP to dUMP, providing the nucleotide substrate for thymidylate synthase. The enzyme binds Zn++, which is required for catalytic activity. The activity of the...; Region: deoxycytidylate_deaminase; cd01286
365659004368	catalytic motif [active]
365659004369	Zn binding site [ion binding]; other site
365659004370	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
365659004371	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
365659004372	Uncharacterized protein conserved in bacteria [Function unknown]; Region: DegV; COG1307
365659004373	Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645
365659004374	HI0933-like protein; Region: HI0933_like; pfam03486
365659004375	Protein of unknown function (DUF1697); Region: DUF1697; pfam08002
365659004376	Helix-Turn-Helix DNA binding domain of the transcription regulators TipAL, Mta, and SkgA; Region: HTH_TipAL-Mta; cd01106
365659004377	MerR HTH family regulatory protein; Region: MerR_1; pfam13411
365659004378	DNA binding residues [nucleotide binding]
365659004379	dimer interface [polypeptide binding]; other site
365659004380	TipAS antibiotic-recognition domain; Region: TipAS; pfam07739
365659004381	solute carrier 6 subfamily, Fusobacterium nucleatum Tyt1-like; solute-binding domain; Region: SLC6sbd_Tyt1-Like; cd10336
365659004382	Na2 binding site [ion binding]; other site
365659004383	putative substrate binding site 1 [chemical binding]; other site
365659004384	Na binding site 1 [ion binding]; other site
365659004385	putative substrate binding site 2 [chemical binding]; other site
365659004386	Phosphomannose isomerase [Carbohydrate transport and metabolism]; Region: ManA; COG1482
365659004387	mannose-6-phosphate isomerase, class I; Region: manA; TIGR00218
365659004388	Sugar efflux transporter for intercellular exchange; Region: MtN3_slv; pfam03083
365659004389	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
365659004390	ATP-binding cassette domain of multidrug resistance protein-like transporters; Region: ABCC_MRP_Like; cd03228
365659004391	Walker A/P-loop; other site
365659004392	ATP binding site [chemical binding]; other site
365659004393	Q-loop/lid; other site
365659004394	ABC transporter signature motif; other site
365659004395	Walker B; other site
365659004396	D-loop; other site
365659004397	H-loop/switch region; other site
365659004398	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
365659004399	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632
365659004400	active site
365659004401	Pyrimidine (PYR) binding domain of POX; Region: TPP_PYR_POX; cd07039
365659004402	pyruvate oxidase; Region: pyruv_oxi_spxB; TIGR02720
365659004403	PYR/PP interface [polypeptide binding]; other site
365659004404	dimer interface [polypeptide binding]; other site
365659004405	tetramer interface [polypeptide binding]; other site
365659004406	TPP binding site [chemical binding]; other site
365659004407	Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205
365659004408	Thiamine pyrophosphate (TPP) family, Pyruvate oxidase (POX) subfamily, TPP-binding module; composed of proteins similar to Lactobacillus plantarum POX, which plays a key role in controlling acetate production under aerobic conditions. POX decarboxylates...; Region: TPP_POX; cd02014
365659004409	TPP-binding site [chemical binding]; other site
365659004410	Cupredoxin-like domain; Region: Cupredoxin_1; cl17234
365659004411	copper-(or silver)-translocating P-type ATPase; Region: ATPase-IB1_Cu; TIGR01511
365659004412	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
365659004413	haloacid dehalogenase-like hydrolase; Region: HAD; cl17202
365659004414	Cupredoxin-like domain; Region: Cupredoxin_1; pfam13473
365659004415	Predicted transcriptional regulator [Transcription]; Region: COG3682
365659004416	copper transport repressor, CopY/TcrY family; Region: CopY_TcrY; TIGR02698
365659004417	L-Lactate oxidase (LOX) FMN-binding domain. LOX is a member of the family of FMN-containing alpha-hydroxyacid oxidases and catalyzes the oxidation of l-lactate using molecular oxygen to generate pyruvate and H2O2.  This family occurs in both prokaryotes...; Region: LOX_like_FMN; cd04737
365659004418	teramer interface [polypeptide binding]; other site
365659004419	active site
365659004420	FMN binding site [chemical binding]; other site
365659004421	catalytic residues [active]
365659004422	ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215
365659004423	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
365659004424	dimer interface [polypeptide binding]; other site
365659004425	conserved gate region; other site
365659004426	putative PBP binding loops; other site
365659004427	ABC-ATPase subunit interface; other site
365659004428	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
365659004429	dimer interface [polypeptide binding]; other site
365659004430	conserved gate region; other site
365659004431	putative PBP binding loops; other site
365659004432	ABC-ATPase subunit interface; other site
365659004433	ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126
365659004434	ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262
365659004435	Walker A/P-loop; other site
365659004436	ATP binding site [chemical binding]; other site
365659004437	Q-loop/lid; other site
365659004438	ABC transporter signature motif; other site
365659004439	Walker B; other site
365659004440	D-loop; other site
365659004441	H-loop/switch region; other site
365659004442	Bacterial periplasmic substrate-binding proteins; Region: PBPb; smart00062
365659004443	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
365659004444	substrate binding pocket [chemical binding]; other site
365659004445	membrane-bound complex binding site; other site
365659004446	hinge residues; other site
365659004447	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
365659004448	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
365659004449	Walker A/P-loop; other site
365659004450	ATP binding site [chemical binding]; other site
365659004451	Q-loop/lid; other site
365659004452	ABC transporter signature motif; other site
365659004453	Walker B; other site
365659004454	D-loop; other site
365659004455	H-loop/switch region; other site
365659004456	Predicted membrane-associated HD superfamily hydrolase [General function prediction only]; Region: COG1480
365659004457	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
365659004458	active site
365659004459	Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725
365659004460	active site
365659004461	dimer interface [polypeptide binding]; other site
365659004462	Cell division septal protein [Cell envelope biogenesis, outer membrane]; Region: FtsQ; COG1589
365659004463	POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478
365659004464	Cell division protein FtsQ; Region: FtsQ; pfam03799
365659004465	undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726
365659004466	MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785
365659004467	homodimer interface [polypeptide binding]; other site
365659004468	active site
365659004469	UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK02472
365659004470	Alanine dehydrogenase/PNT, C-terminal domain; Region: AlaDh_PNT_C; smart01002
365659004471	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
365659004472	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
365659004473	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
365659004474	putative bacteriocin export ABC transporter, lactococcin 972 group; Region: L_ocin_972_ABC; TIGR03608
365659004475	Walker A/P-loop; other site
365659004476	ATP binding site [chemical binding]; other site
365659004477	Q-loop/lid; other site
365659004478	ABC transporter signature motif; other site
365659004479	Walker B; other site
365659004480	D-loop; other site
365659004481	H-loop/switch region; other site
365659004482	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4652
365659004483	Protein of unknown function (DUF1430); Region: DUF1430; pfam07242
365659004484	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464
365659004485	Transposase; Region: DDE_Tnp_ISL3; pfam01610
365659004486	Predicted membrane GTPase involved in stress response [Signal transduction mechanisms]; Region: TypA; COG1217
365659004487	Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891
365659004488	G1 box; other site
365659004489	putative GEF interaction site [polypeptide binding]; other site
365659004490	GTP/Mg2+ binding site [chemical binding]; other site
365659004491	Switch I region; other site
365659004492	G2 box; other site
365659004493	G3 box; other site
365659004494	Switch II region; other site
365659004495	G4 box; other site
365659004496	G5 box; other site
365659004497	BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu.  BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691
365659004498	BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants.  BipA is a highly...; Region: BipA_TypA_C; cd03710
365659004499	16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187
365659004500	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cl09940
365659004501	RNA binding surface [nucleotide binding]; other site
365659004502	Pseudouridine synthase, Escherichia coli RsuA like; Region: PseudoU_synth_RsuA; cd02553
365659004503	active site
365659004504	uracil binding [chemical binding]; other site
365659004505	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158
365659004506	active site residue [active]
365659004507	Bacterial protein of unknown function (DUF910); Region: DUF910; pfam06014
365659004508	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
365659004509	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
365659004510	active site
365659004511	phosphorylation site [posttranslational modification]
365659004512	intermolecular recognition site; other site
365659004513	dimerization interface [polypeptide binding]; other site
365659004514	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
365659004515	DNA binding residues [nucleotide binding]
365659004516	dimerization interface [polypeptide binding]; other site
365659004517	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585
365659004518	Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518
365659004519	FtsX-like permease family; Region: FtsX; pfam02687
365659004520	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
365659004521	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
365659004522	Walker A/P-loop; other site
365659004523	ATP binding site [chemical binding]; other site
365659004524	Q-loop/lid; other site
365659004525	ABC transporter signature motif; other site
365659004526	Walker B; other site
365659004527	D-loop; other site
365659004528	H-loop/switch region; other site
365659004529	Transcriptional regulator [Transcription]; Region: LysR; COG0583
365659004530	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
365659004531	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
365659004532	dimerization interface [polypeptide binding]; other site
365659004533	stage V sporulation protein K; Region: spore_V_K; TIGR02881
365659004534	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
365659004535	Walker A motif; other site
365659004536	ATP binding site [chemical binding]; other site
365659004537	Walker B motif; other site
365659004538	arginine finger; other site
365659004539	stage V sporulation protein K; Region: spore_V_K; TIGR02881
365659004540	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
365659004541	Walker A motif; other site
365659004542	ATP binding site [chemical binding]; other site
365659004543	Walker B motif; other site
365659004544	arginine finger; other site
365659004545	FOG: Glucan-binding domain (YG repeat) [General function prediction only]; Region: COG5263
365659004546	Protein of unknown function (DUF3990); Region: DUF3990; pfam13151
365659004547	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
365659004548	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
365659004549	non-specific DNA binding site [nucleotide binding]; other site
365659004550	salt bridge; other site
365659004551	sequence-specific DNA binding site [nucleotide binding]; other site
365659004552	Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300
365659004553	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
365659004554	NAD(P) binding site [chemical binding]; other site
365659004555	active site
365659004556	ribonuclease Z; Region: RNase_Z; TIGR02651
365659004557	Galactose-1-phosphate uridyl transferase, N-terminal domain; Region: GalP_UDP_transf; pfam01087
365659004558	GTPases [General function prediction only]; Region: HflX; COG2262
365659004559	GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167
365659004560	HflX GTPase family; Region: HflX; cd01878
365659004561	G1 box; other site
365659004562	GTP/Mg2+ binding site [chemical binding]; other site
365659004563	Switch I region; other site
365659004564	G2 box; other site
365659004565	G3 box; other site
365659004566	Switch II region; other site
365659004567	G4 box; other site
365659004568	G5 box; other site
365659004569	tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324
365659004570	tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091
365659004571	Protein of unknown function (DUF3042); Region: DUF3042; pfam11240
365659004572	thymidylate synthase; Reviewed; Region: thyA; PRK01827
365659004573	Thymidylate synthase and pyrimidine hydroxymethylase: Thymidylate synthase (TS) and deoxycytidylate hydroxymethylase (dCMP-HMase) are homologs that catalyze analogous alkylation of C5 of pyrimidine nucleotides. Both enzymes are involved in the...; Region: TS_Pyrimidine_HMase; cd00351
365659004574	dimerization interface [polypeptide binding]; other site
365659004575	active site
365659004576	ROK family protein (putative glucokinase); Region: ROK_glcA_fam; TIGR00744
365659004577	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012
365659004578	nucleotide binding site [chemical binding]; other site
365659004579	FOG: Glucan-binding domain (YG repeat) [General function prediction only]; Region: COG5263
365659004580	Excalibur calcium-binding domain; Region: Excalibur; smart00894
365659004581	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
365659004582	aminodeoxychorismate synthase; Provisional; Region: PRK07508
365659004583	aminodeoxychorismate synthase, component I, bacterial clade; Region: pabB; TIGR00553
365659004584	substrate-cofactor binding pocket; other site
365659004585	homodimer interface [polypeptide binding]; other site
365659004586	Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115
365659004587	PyridoxaL 5'-Phosphate Dependent Enzymes class IV (PLPDE_IV). This D-amino acid superfamily, one of five classes of PLPDE, consists of branched-chain amino acid aminotransferases (BCAT), D-amino acid transferases (DAAT), and...; Region: PLPDE_IV; cl00224
365659004588	pyridoxal 5'-phosphate binding site [chemical binding]; other site
365659004589	catalytic residue [active]
365659004590	Gram-positive signal peptide, YSIRK family; Region: YSIRK_signal; TIGR01168
365659004591	G5 domain; Region: G5; pfam07501
365659004592	G5 domain; Region: G5; pfam07501
365659004593	G5 domain; Region: G5; pfam07501
365659004594	M26 IgA1-specific Metallo-endopeptidase N-terminal region; Region: Peptidase_M26_N; pfam05342
365659004595	M26 IgA1-specific Metallo-endopeptidase C-terminal region; Region: Peptidase_M26_C; pfam07580
365659004596	hypothetical protein; Provisional; Region: PRK13690
365659004597	Predicted signal transduction protein with a C-terminal ATPase domain [Signal transduction mechanisms]; Region: COG2972
365659004598	Cache domain; Region: Cache_1; pfam02743
365659004599	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
365659004600	dimerization interface [polypeptide binding]; other site
365659004601	Histidine kinase; Region: His_kinase; pfam06580
365659004602	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
365659004603	ATP binding site [chemical binding]; other site
365659004604	Mg2+ binding site [ion binding]; other site
365659004605	G-X-G motif; other site
365659004606	Response regulator receiver domain; Region: Response_reg; pfam00072
365659004607	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
365659004608	active site
365659004609	phosphorylation site [posttranslational modification]
365659004610	intermolecular recognition site; other site
365659004611	dimerization interface [polypeptide binding]; other site
365659004612	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
365659004613	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
365659004614	Peptide methionine sulfoxide reductase [Posttranslational modification, protein turnover, chaperones]; Region: MsrA; COG0225
365659004615	Conserved domain frequently associated with peptide methionine sulfoxide reductase [Posttranslational modification, protein turnover, chaperones]; Region: COG0229
365659004616	SelR domain; Region: SelR; pfam01641
365659004617	TlpA-like family; composed of  TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966
365659004618	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
365659004619	catalytic residues [active]
365659004620	Cytochrome c biogenesis protein [Posttranslational modification, protein turnover, chaperones]; Region: CcdA; COG0785
365659004621	Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788
365659004622	PD-(D/E)XK nuclease family transposase; Region: PDDEXK_2; pfam12784
365659004623	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
365659004624	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
365659004625	NAD synthase [Coenzyme metabolism]; Region: NadE; COG0171
365659004626	NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553
365659004627	homodimer interface [polypeptide binding]; other site
365659004628	NAD binding pocket [chemical binding]; other site
365659004629	ATP binding pocket [chemical binding]; other site
365659004630	Mg binding site [ion binding]; other site
365659004631	active-site loop [active]
365659004632	nicotinate phosphoribosyltransferase; Validated; Region: PRK09243
365659004633	Nicotinate phosphoribosyltransferase (NAPRTase), subgroup A. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting, reaction...; Region: NAPRTase_A; cd01570
365659004634	active site
365659004635	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
365659004636	non-specific DNA binding site [nucleotide binding]; other site
365659004637	salt bridge; other site
365659004638	sequence-specific DNA binding site [nucleotide binding]; other site
365659004639	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
365659004640	Coenzyme A binding pocket [chemical binding]; other site
365659004641	Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113
365659004642	transcription elongation factor GreA; Reviewed; Region: greA; PRK00226
365659004643	Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449
365659004644	Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272
365659004645	Aminodeoxychorismate lyase [Coenzyme transport and metabolism]; Region: COG1559
365659004646	proteins similar to Escherichia coli yceG; Region: yceG_like; cd08010
365659004647	dimerization interface [polypeptide binding]; other site
365659004648	Acetyltransferases [General function prediction only]; Region: RimI; COG0456
365659004649	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
365659004650	Acetyltransferase (GNAT) domain; Region: Acetyltransf_7; pfam13508
365659004651	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
365659004652	Coenzyme A binding pocket [chemical binding]; other site
365659004653	UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421
365659004654	Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225
365659004655	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
365659004656	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
365659004657	Bacterial SNF2 helicase associated; Region: SNF2_assoc; pfam08455
365659004658	Superfamily II DNA/RNA helicases, SNF2 family [Transcription / DNA replication, recombination, and repair]; Region: HepA; COG0553
365659004659	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
365659004660	ATP binding site [chemical binding]; other site
365659004661	putative Mg++ binding site [ion binding]; other site
365659004662	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
365659004663	nucleotide binding region [chemical binding]; other site
365659004664	ATP-binding site [chemical binding]; other site
365659004665	Abi-like protein; Region: Abi_2; cl01988
365659004666	Abi-like protein; Region: Abi_2; pfam07751
365659004667	Bifunctional PLP-dependent enzyme with beta-cystathionase and maltose regulon repressor activities [Amino acid transport and metabolism]; Region: MalY; COG1168
365659004668	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
365659004669	pyridoxal 5'-phosphate binding site [chemical binding]; other site
365659004670	homodimer interface [polypeptide binding]; other site
365659004671	catalytic residue [active]
365659004672	cystathionine gamma-synthase; Reviewed; Region: PRK07269
365659004673	CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614
365659004674	homodimer interface [polypeptide binding]; other site
365659004675	substrate-cofactor binding pocket; other site
365659004676	pyridoxal 5'-phosphate binding site [chemical binding]; other site
365659004677	catalytic residue [active]
365659004678	ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166
365659004679	The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504
365659004680	peptide binding site [polypeptide binding]; other site
365659004681	Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244
365659004682	Stage V sporulation protein B, also known as Stage III sporulation protein F, and related proteins; Region: MATE_SpoVB_like; cd13124
365659004683	UDP-N-acetylmuramoylalanyl-D-glutamate--L-lysine ligase; Provisional; Region: PRK14022
365659004684	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
365659004685	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
365659004686	Domain of unknown function (DUF1803); Region: DUF1803; pfam08820
365659004687	Domain of unknown function (DUF1803); Region: DUF1803; pfam08820
365659004688	Orthopoxvirus protein of unknown function (DUF830); Region: DUF830; cl13998
365659004689	putative manganese-dependent inorganic pyrophosphatase; Provisional; Region: PRK05427
365659004690	DHH family; Region: DHH; pfam01368
365659004691	DHHA2 domain; Region: DHHA2; pfam02833
365659004692	The GIY-YIG domain of uncharacterized protein family UPF0213 related to structure-specific endonuclease SLX1; Region: GIY-YIG_UPF0213; cd10456
365659004693	GIY-YIG motif/motif A; other site
365659004694	putative active site [active]
365659004695	putative metal binding site [ion binding]; other site
365659004696	Predicted O-methyltransferase [General function prediction only]; Region: COG4123
365659004697	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
365659004698	S-adenosylmethionine binding site [chemical binding]; other site
365659004699	hypothetical protein; Provisional; Region: PRK07252
365659004700	general stress protein 13; Validated; Region: PRK08059
365659004701	RNA binding site [nucleotide binding]; other site
365659004702	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
365659004703	haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282
365659004704	active site
365659004705	motif I; other site
365659004706	motif II; other site
365659004707	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
365659004708	Peptidyl-prolyl cis-trans isomerase (rotamase) - cyclophilin family [Posttranslational modification, protein turnover, chaperones]; Region: PpiB; COG0652
365659004709	active site
365659004710	30S ribosomal protein S18; Reviewed; Region: rpsR; PRK00391
365659004711	Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629
365659004712	SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496
365659004713	dimer interface [polypeptide binding]; other site
365659004714	ssDNA binding site [nucleotide binding]; other site
365659004715	tetramer (dimer of dimers) interface [polypeptide binding]; other site
365659004716	30S ribosomal protein S6; Reviewed; Region: rpsF; PRK00453
365659004717	Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826
365659004718	Helix-turn-helix domain; Region: HTH_38; pfam13936
365659004719	Integrase core domain; Region: rve; pfam00665
365659004720	asparaginyl-tRNA synthetase; Validated; Region: asnC; PRK03932
365659004721	AsnRS_cyto_like_N: N-terminal, anticodon recognition domain of the type found in human and Saccharomyces cerevisiae cytoplasmic asparaginyl-tRNA synthetase (AsnRS), in Brugia malayai AsnRs and, in various putative bacterial AsnRSs.  This domain is a...; Region: AsnRS_cyto_like_N; cd04323
365659004722	putative dimer interface [polypeptide binding]; other site
365659004723	putative anticodon binding site; other site
365659004724	Asx tRNA synthetase (AspRS/AsnRS) class II core domain.  Assignment to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs in the core domain. This family includes AsnRS as well as...; Region: AsxRS_core; cd00776
365659004725	homodimer interface [polypeptide binding]; other site
365659004726	motif 1; other site
365659004727	motif 2; other site
365659004728	active site
365659004729	motif 3; other site
365659004730	This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_19; cd07262
365659004731	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
365659004732	aspartate aminotransferase; Provisional; Region: PRK05764
365659004733	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
365659004734	pyridoxal 5'-phosphate binding site [chemical binding]; other site
365659004735	homodimer interface [polypeptide binding]; other site
365659004736	catalytic residue [active]
365659004737	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5353
365659004738	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
365659004739	Major Facilitator Superfamily; Region: MFS_1; pfam07690
365659004740	putative substrate translocation pore; other site
365659004741	Predicted flavoprotein [General function prediction only]; Region: COG0431
365659004742	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
365659004743	G5 domain; Region: G5; pfam07501
365659004744	Collagen triple helix repeat (20 copies); Region: Collagen; pfam01391
365659004745	Collagen triple helix repeat (20 copies); Region: Collagen; pfam01391
365659004746	Collagen triple helix repeat (20 copies); Region: Collagen; pfam01391
365659004747	Collagen triple helix repeat (20 copies); Region: Collagen; pfam01391
365659004748	Collagen triple helix repeat (20 copies); Region: Collagen; pfam01391
365659004749	Collagen triple helix repeat (20 copies); Region: Collagen; pfam01391
365659004750	Collagen triple helix repeat (20 copies); Region: Collagen; pfam01391
365659004751	Streptococcal surface-anchored protein repeat, S. criceti family; Region: RPT_S_cricet; TIGR04203
365659004752	Streptococcal surface-anchored protein repeat, S. criceti family; Region: RPT_S_cricet; TIGR04203
365659004753	Streptococcal surface-anchored protein repeat, S. criceti family; Region: RPT_S_cricet; TIGR04203
365659004754	Streptococcal surface-anchored protein repeat, S. criceti family; Region: RPT_S_cricet; TIGR04203
365659004755	Streptococcal surface-anchored protein repeat, S. criceti family; Region: RPT_S_cricet; TIGR04203
365659004756	M protein trans-acting positive regulator (MGA) HTH domain; Region: HTH_Mga; pfam08280
365659004757	Mga helix-turn-helix domain; Region: Mga; pfam05043
365659004758	M protein trans-acting positive regulator (MGA) PRD domain; Region: PRD_Mga; pfam08270
365659004759	hypothetical protein; Validated; Region: PRK02101
365659004760	Gram-positive signal peptide, YSIRK family; Region: YSIRK_signal; TIGR01168
365659004761	Beta-galactosidase/beta-glucuronidase [Carbohydrate transport and metabolism]; Region: LacZ; COG3250
365659004762	Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837
365659004763	Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703
365659004764	Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836
365659004765	Bacterial Ig-like domain (group 4); Region: Big_4; pfam07532
365659004766	Bacterial Ig-like domain (group 4); Region: Big_4; pfam07532
365659004767	Bacterial Ig-like domain (group 4); Region: Big_4; pfam07532
365659004768	Bacterial Ig-like domain (group 4); Region: Big_4; pfam07532
365659004769	Bacterial Ig-like domain (group 4); Region: Big_4; pfam07532
365659004770	G5 domain; Region: G5; pfam07501
365659004771	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464
365659004772	Transposase; Region: DDE_Tnp_ISL3; pfam01610
365659004773	Transposase; Region: DEDD_Tnp_IS110; pfam01548
365659004774	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547
365659004775	Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371
365659004776	Gram-positive signal peptide, YSIRK family; Region: YSIRK_signal; TIGR01168
365659004777	F5/8 type C domain; Region: F5_F8_type_C; pfam00754
365659004778	Glycosyl hydrolase family 20, catalytic domain; Region: Glyco_hydro_20; pfam00728
365659004779	Glycosyl hydrolase family 20 (GH20) catalytic domain of dispersin B (DspB), lacto-N-biosidase (LnbB) and related proteins. Dispersin B is a soluble beta-N-acetylglucosamidase found in bacteria that hydrolyzes the beta-1,6-linkages of PGA (poly-beta-(1,6)...; Region: GH20_DspB_LnbB-like; cd06564
365659004780	active site
365659004781	F5/8 type C domain; Region: F5_F8_type_C; pfam00754
365659004782	beta-N-acetylglucosaminidase; Region: NAGidase; pfam07555
365659004783	F5/8 type C domain; Region: F5_F8_type_C; pfam00754
365659004784	sugar binding site [chemical binding]; other site
365659004785	F5/8 type C domain; Region: F5_F8_type_C; pfam00754
365659004786	Gram-positive signal peptide, YSIRK family; Region: YSIRK_signal; TIGR01168
365659004787	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265
365659004788	Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365
365659004789	Endo-alpha-N-acetylgalactosaminidase; Region: Glyco_hydro_101; pfam12905
365659004790	F5/8 type C domain; Region: F5_F8_type_C; pfam00754
365659004791	hypothetical protein; Validated; Region: PRK02101
365659004792	Protein of unknown function (DUF3953); Region: DUF3953; pfam13129
365659004793	Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487
365659004794	active site
365659004795	catalytic residues [active]
365659004796	metal binding site [ion binding]; metal-binding site
365659004797	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474
365659004798	Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; smart00831
365659004799	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
365659004800	Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246
365659004801	haloacid dehalogenase-like hydrolase; Region: HAD; pfam12710
365659004802	Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689
365659004803	Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053
365659004804	Cation efflux family; Region: Cation_efflux; pfam01545
365659004805	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4994
365659004806	ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488
365659004807	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
365659004808	Walker A/P-loop; other site
365659004809	ATP binding site [chemical binding]; other site
365659004810	Q-loop/lid; other site
365659004811	ABC transporter signature motif; other site
365659004812	Walker B; other site
365659004813	D-loop; other site
365659004814	H-loop/switch region; other site
365659004815	ABC transporter; Region: ABC_tran_2; pfam12848
365659004816	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
365659004817	tRNA CCA-pyrophosphorylase; Provisional; Region: PRK13299
365659004818	Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398
365659004819	active site
365659004820	NTP binding site [chemical binding]; other site
365659004821	metal binding triad [ion binding]; metal-binding site
365659004822	Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627
365659004823	tRNA nucleotidyltransferase domain 2 putative; Region: tRNA_NucTran2_2; pfam13735
365659004824	dihydrodipicolinate reductase; Provisional; Region: PRK00048
365659004825	Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113
365659004826	Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173
365659004827	EDD domain protein, DegV family; Region: DegV; TIGR00762
365659004828	Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645
365659004829	Protein of unknown function (DUF1149); Region: DUF1149; cl11551
365659004830	phosphoglucosamine mutase; Provisional; Region: glmM; PRK14316
365659004831	GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802
365659004832	active site
365659004833	substrate binding site [chemical binding]; other site
365659004834	metal binding site [ion binding]; metal-binding site
365659004835	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4856
365659004836	YbbR-like protein; Region: YbbR; pfam07949
365659004837	Uncharacterized conserved protein [Function unknown]; Region: COG1624
365659004838	DisA bacterial checkpoint controller nucleotide-binding; Region: DisA_N; pfam02457
365659004839	Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492
365659004840	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
365659004841	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
365659004842	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1481
365659004843	Sporulation Regulator WhiA N terminal; Region: WhiA_N; pfam10298
365659004844	conserved hypothetical protein, cofD-related; Region: CofD_related; TIGR01826
365659004845	Family of CofD-like proteins and proteins related to YvcK; Region: CofD_YvcK; cd07044
365659004846	dimer interface [polypeptide binding]; other site
365659004847	phosphate binding site [ion binding]; other site
365659004848	glmZ(sRNA)-inactivating NTPase; Provisional; Region: PRK05416
365659004849	YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448
365659004850	homotrimer interaction site [polypeptide binding]; other site
365659004851	putative active site [active]
365659004852	YihA (EngB) GTPase family; Region: YihA_EngB; cd01876
365659004853	G1 box; other site
365659004854	GTP/Mg2+ binding site [chemical binding]; other site
365659004855	Switch I region; other site
365659004856	G2 box; other site
365659004857	G3 box; other site
365659004858	Switch II region; other site
365659004859	G4 box; other site
365659004860	G5 box; other site
365659004861	ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342
365659004862	ClpX C4-type zinc finger; Region: zf-C4_ClpX; pfam06689
365659004863	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
365659004864	Walker A motif; other site
365659004865	ATP binding site [chemical binding]; other site
365659004866	Walker B motif; other site
365659004867	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086
365659004868	Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262
365659004869	Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cd00209
365659004870	folate binding site [chemical binding]; other site
365659004871	NADP+ binding site [chemical binding]; other site
365659004872	DNA-binding ferritin-like protein (oxidative damage protectant) [Inorganic ion transport and metabolism]; Region: Dps; COG0783
365659004873	DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043
365659004874	dimerization interface [polypeptide binding]; other site
365659004875	DPS ferroxidase diiron center [ion binding]; other site
365659004876	ion pore; other site
365659004877	FOG: Glucan-binding domain (YG repeat) [General function prediction only]; Region: COG5263
365659004878	Endo-N-acetylmuramidases (muramidases) are lysozymes (also referred to as peptidoglycan hydrolases) that degrade bacterial cell walls by catalyzing the hydrolysis of 1,4-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues; Region: GH25_muramidase; cl10448
365659004879	Glycosyl hydrolases family 25; Region: Glyco_hydro_25; pfam01183
365659004880	active site
365659004881	triosephosphate isomerase; Provisional; Region: PRK14567
365659004882	Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311
365659004883	substrate binding site [chemical binding]; other site
365659004884	dimer interface [polypeptide binding]; other site
365659004885	catalytic triad [active]
365659004886	Putative primosome component and related proteins [DNA replication, recombination, and repair]; Region: DnaD; COG3935
365659004887	DnaD and phage-associated domain; Region: DnaD_dom; TIGR01446
365659004888	Homoserine trans-succinylase [Amino acid transport and metabolism]; Region: MetA; COG1897
365659004889	Type 1 glutamine amidotransferase (GATase1)-like domain found in homoserine trans-succinylase (HTS); Region: GATase1_HTS; cd03131
365659004890	proposed active site lysine [active]
365659004891	conserved cys residue [active]
365659004892	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
365659004893	active site
365659004894	Methyltransferase domain; Region: Methyltransf_31; pfam13847
365659004895	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
365659004896	S-adenosylmethionine binding site [chemical binding]; other site
365659004897	Ribosomal protein L1.  The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA.  In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403
365659004898	mRNA/rRNA interface [nucleotide binding]; other site
365659004899	50S ribosomal protein L11; Validated; Region: rplK; PRK00140
365659004900	Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349
365659004901	23S rRNA interface [nucleotide binding]; other site
365659004902	L7/L12 interface [polypeptide binding]; other site
365659004903	putative thiostrepton binding site; other site
365659004904	L25 interface [polypeptide binding]; other site
365659004905	D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: VanY; COG1876
365659004906	D-alanyl-D-alanine carboxypeptidase; Region: VanY; pfam02557
365659004907	Diadenosine tetraphosphate (Ap4A) hydrolase and other HIT family hydrolases [Nucleotide transport and metabolism / Carbohydrate transport and metabolism / General function prediction only]; Region: Hit; COG0537
365659004908	nucleotide binding site/active site [active]
365659004909	HIT family signature motif; other site
365659004910	catalytic residue [active]
365659004911	Cellulase M and related proteins [Carbohydrate transport and metabolism]; Region: FrvX; COG1363
365659004912	M42 Peptidase, Endoglucanase-like subfamily; Region: M42_glucanase_like; cd05657
365659004913	putative oligomer interface [polypeptide binding]; other site
365659004914	putative active site [active]
365659004915	metal binding site [ion binding]; metal-binding site
365659004916	Branched-chain amino acid transport protein; Region: Branch_AA_trans; pfam05525
365659004917	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158
365659004918	active site residue [active]
365659004919	Uncharacterized subfamily of Uracil-DNA glycosylases; Region: UDG_like_1; cd10033
365659004920	putative uracil binding site [chemical binding]; other site
365659004921	putative active site [active]
365659004922	dipeptidase PepV; Reviewed; Region: PRK07318
365659004923	M20 Peptidase Xaa-His dipeptidase (PepV) degrades hydrophobic dipeptides; Region: M20_PepV; cd03888
365659004924	active site
365659004925	metal binding site [ion binding]; metal-binding site
365659004926	Nitroreductase-like family 1. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_1; cd02137
365659004927	dimer interface [polypeptide binding]; other site
365659004928	FMN binding site [chemical binding]; other site
365659004929	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
365659004930	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
365659004931	substrate binding pocket [chemical binding]; other site
365659004932	membrane-bound complex binding site; other site
365659004933	hinge residues; other site
365659004934	Calcineurin-like phosphoesterase superfamily domain; Region: Metallophos_2; pfam12850
365659004935	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
365659004936	active site
365659004937	metal binding site [ion binding]; metal-binding site
365659004938	excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558
365659004939	Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434
365659004940	GIY-YIG motif/motif A; other site
365659004941	active site
365659004942	catalytic site [active]
365659004943	putative DNA binding site [nucleotide binding]; other site
365659004944	metal binding site [ion binding]; metal-binding site
365659004945	UvrB/uvrC motif; Region: UVR; pfam02151
365659004946	UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459
365659004947	Zinc-dependent metalloprotease, MMP_like subfamily. This group contains matrix metalloproteinases (MMPs), serralysins, and the astacin_like family of proteases; Region: ZnMc_MMP_like; cd04268
365659004948	active site
365659004949	FemAB family; Region: FemAB; pfam02388
365659004950	FemAB family; Region: FemAB; pfam02388
365659004951	Acetyltransferase (GNAT) domain; Region: Acetyltransf_6; cl17497
365659004952	Predicted esterase [General function prediction only]; Region: COG0627
365659004953	S-formylglutathione hydrolase; Region: PLN02442
365659004954	mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595
365659004955	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
365659004956	RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521
365659004957	single-stranded-DNA-specific exonuclease RecJ; Region: recJ; TIGR00644
365659004958	DHH family; Region: DHH; pfam01368
365659004959	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4199
365659004960	ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126
365659004961	ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262
365659004962	Walker A/P-loop; other site
365659004963	ATP binding site [chemical binding]; other site
365659004964	Q-loop/lid; other site
365659004965	ABC transporter signature motif; other site
365659004966	Walker B; other site
365659004967	D-loop; other site
365659004968	H-loop/switch region; other site
365659004969	bifunctional adhesin/ABC transporter aspartate/glutamate-binding protein; Reviewed; Region: PRK11917
365659004970	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
365659004971	substrate binding pocket [chemical binding]; other site
365659004972	membrane-bound complex binding site; other site
365659004973	hinge residues; other site
365659004974	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
365659004975	dimer interface [polypeptide binding]; other site
365659004976	conserved gate region; other site
365659004977	ABC-ATPase subunit interface; other site
365659004978	ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215
365659004979	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
365659004980	dimer interface [polypeptide binding]; other site
365659004981	conserved gate region; other site
365659004982	putative PBP binding loops; other site
365659004983	ABC-ATPase subunit interface; other site
365659004984	glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650
365659004985	The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301
365659004986	Walker A/P-loop; other site
365659004987	ATP binding site [chemical binding]; other site
365659004988	Q-loop/lid; other site
365659004989	ABC transporter signature motif; other site
365659004990	Walker B; other site
365659004991	D-loop; other site
365659004992	H-loop/switch region; other site
365659004993	TOBE domain; Region: TOBE_2; pfam08402
365659004994	Regulator of polyketide synthase expression [Signal transduction mechanisms / Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2508
365659004995	PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556
365659004996	Ribonuclease III family protein [Replication, recombination, and    repair]; Region: COG1939
365659004997	active site
365659004998	metal binding site [ion binding]; metal-binding site
365659004999	dimerization interface [polypeptide binding]; other site
365659005000	cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260
365659005001	catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672
365659005002	active site
365659005003	HIGH motif; other site
365659005004	catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672
365659005005	KMSKS motif; other site
365659005006	Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020
365659005007	tRNA binding surface [nucleotide binding]; other site
365659005008	anticodon binding site; other site
365659005009	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
365659005010	Coenzyme A binding pocket [chemical binding]; other site
365659005011	Acetyltransferase (GNAT) domain; Region: Acetyltransf_8; pfam13523
365659005012	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
365659005013	Coenzyme A binding pocket [chemical binding]; other site
365659005014	Serine acetyltransferase [Amino acid transport and metabolism]; Region: CysE; COG1045
365659005015	Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354
365659005016	trimer interface [polypeptide binding]; other site
365659005017	active site
365659005018	substrate binding site [chemical binding]; other site
365659005019	polynucleotide phosphorylase/polyadenylase; Provisional; Region: PRK11824
365659005020	Polyribonucleotide nucleotidyltransferase, repeat 1; Region: RNase_PH_PNPase_1; cd11363
365659005021	RNase E interface [polypeptide binding]; other site
365659005022	trimer interface [polypeptide binding]; other site
365659005023	Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726
365659005024	Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364
365659005025	RNase E interface [polypeptide binding]; other site
365659005026	trimer interface [polypeptide binding]; other site
365659005027	active site
365659005028	Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393
365659005029	S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase  is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472
365659005030	RNA binding site [nucleotide binding]; other site
365659005031	domain interface; other site
365659005032	Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cd00537
365659005033	FAD binding site [chemical binding]; other site
365659005034	5-methyltetrahydropteroyltriglutamate--homocysteine S-methyltransferase; Provisional; Region: PRK05222
365659005035	CIMS - Cobalamine-independent methonine synthase, or MetE, N-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_N_terminal_like; cd03312
365659005036	THF binding site; other site
365659005037	CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311
365659005038	substrate binding site [chemical binding]; other site
365659005039	THF binding site; other site
365659005040	zinc-binding site [ion binding]; other site
365659005041	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3666
365659005042	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
365659005043	Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751
365659005044	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
365659005045	conserved hypothetical protein; Region: TIGR02328
365659005046	Pyrimidine dimer DNA glycosylase; Region: Pyr_excise; pfam03013
365659005047	Protein of unknown function (DUF1722); Region: DUF1722; pfam08349
365659005048	Type I site-specific restriction-modification system, R (restriction) subunit and related helicases [Defense mechanisms]; Region: COG0610
365659005049	Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; pfam04313
365659005050	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
365659005051	ATP binding site [chemical binding]; other site
365659005052	putative Mg++ binding site [ion binding]; other site
365659005053	Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732
365659005054	Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420
365659005055	Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732
365659005056	Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420
365659005057	Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420
365659005058	Virulence protein [General function prediction only]; Region: COG3943
365659005059	Virulence protein RhuM family; Region: Virulence_RhuM; pfam13310
365659005060	type I restriction system adenine methylase (hsdM); Region: hsdM; TIGR00497
365659005061	HsdM N-terminal domain; Region: HsdM_N; pfam12161
365659005062	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
365659005063	S-adenosylmethionine binding site [chemical binding]; other site
365659005064	Protein of unknown function (DUF4238); Region: DUF4238; pfam14022
365659005065	Uncharacterized conserved protein [Function unknown]; Region: COG0398
365659005066	SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335
365659005067	Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940
365659005068	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012
365659005069	nucleotide binding site [chemical binding]; other site
365659005070	PTS system, sucrose-specific IIBC component; Region: PTS-II-BC-sucr; TIGR01996
365659005071	PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212
365659005072	active site turn [active]
365659005073	phosphorylation site [posttranslational modification]
365659005074	Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263
365659005075	PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_glc; cd00210
365659005076	HPr interaction site; other site
365659005077	glycerol kinase (GK) interaction site [polypeptide binding]; other site
365659005078	active site
365659005079	phosphorylation site [posttranslational modification]
365659005080	Beta-fructosidases (levanase/invertase) [Carbohydrate transport and metabolism]; Region: SacC; COG1621
365659005081	Glycosyl hydrolase family 32, beta-fructosidases; Region: GH32_B_Fructosidase; cd08996
365659005082	substrate binding [chemical binding]; other site
365659005083	active site
365659005084	Glycosyl hydrolases family 32 C terminal; Region: Glyco_hydro_32C; pfam08244
365659005085	Transcriptional regulators [Transcription]; Region: PurR; COG1609
365659005086	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
365659005087	DNA binding site [nucleotide binding]
365659005088	domain linker motif; other site
365659005089	Ligand binding domain of the lacI-like transcription regulator from a novel metal-reducing bacterium Alkaliphilus Metalliredigens (strain Qymf) and its close homologs; Region: PBP1_Qymf_like; cd06291
365659005090	dimerization interface [polypeptide binding]; other site
365659005091	ligand binding site [chemical binding]; other site
365659005092	sodium binding site [ion binding]; other site
365659005093	Class II hydroxymethylglutaryl-coenzyme A (HMG-CoA) reductase (HMGR); Region: HMG-CoA_reductase_classII; cd00644
365659005094	homodimer interface [polypeptide binding]; other site
365659005095	catalytic residues [active]
365659005096	NAD binding site [chemical binding]; other site
365659005097	substrate binding pocket [chemical binding]; other site
365659005098	flexible flap; other site
365659005099	"initiating" condensing enzymes are a subclass of decarboxylating condensing enzymes, including beta-ketoacyl [ACP] synthase, type III and polyketide synthases, type III, which include chalcone synthase and related enzymes. They are...; Region: init_cond_enzymes; cd00827
365659005100	3-hydroxy-3-methylglutaryl CoA synthase, prokaryotic clade; Region: HMG-CoA-S_prok; TIGR01835
365659005101	dimer interface [polypeptide binding]; other site
365659005102	active site
365659005103	Uncharacterized conserved protein [Function unknown]; Region: COG3610
365659005104	Uncharacterized conserved protein [Function unknown]; Region: COG2966
365659005105	Protein of unknown function (DUF1212); Region: DUF1212; pfam06738
365659005106	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
365659005107	Catalytic domain of Protein Kinases; Region: PKc; cd00180
365659005108	active site
365659005109	ATP binding site [chemical binding]; other site
365659005110	substrate binding site [chemical binding]; other site
365659005111	activation loop (A-loop); other site
365659005112	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2815
365659005113	PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577
365659005114	PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577
365659005115	PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577
365659005116	Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143
365659005117	active site
365659005118	16S rRNA methyltransferase B; Provisional; Region: PRK14902
365659005119	NusB family; Region: NusB; pfam01029
365659005120	putative RNA binding site [nucleotide binding]; other site
365659005121	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
365659005122	S-adenosylmethionine binding site [chemical binding]; other site
365659005123	methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005
365659005124	Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646
365659005125	putative active site [active]
365659005126	substrate binding site [chemical binding]; other site
365659005127	putative cosubstrate binding site; other site
365659005128	catalytic site [active]
365659005129	C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704
365659005130	substrate binding site [chemical binding]; other site
365659005131	Primosomal protein N' (replication factor Y) - superfamily II helicase [DNA replication, recombination, and repair]; Region: PriA; COG1198
365659005132	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
365659005133	ATP binding site [chemical binding]; other site
365659005134	putative Mg++ binding site [ion binding]; other site
365659005135	helicase superfamily c-terminal domain; Region: HELICc; smart00490
365659005136	ATP-binding site [chemical binding]; other site
365659005137	DNA-directed RNA polymerase subunit omega; Reviewed; Region: rpoZ; PRK00392
365659005138	Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194
365659005139	Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071
365659005140	catalytic site [active]
365659005141	G-X2-G-X-G-K; other site
365659005142	tRNA_anti-like; Region: tRNA_anti-like; pfam12869
365659005143	hypothetical protein; Provisional; Region: PRK00106
365659005144	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
365659005145	Zn2+ binding site [ion binding]; other site
365659005146	Mg2+ binding site [ion binding]; other site
365659005147	Cdc6-related protein, AAA superfamily ATPase [DNA replication, recombination, and repair / Posttranslational modification, protein turnover, chaperones]; Region: CDC6; COG1474
365659005148	hypothetical protein; Provisional; Region: PRK13670
365659005149	HIGH Nucleotidyl Transferase; Region: HIGH_NTase1; pfam05636
365659005150	Methyltransferase domain; Region: Methyltransf_31; pfam13847
365659005151	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
365659005152	S-adenosylmethionine binding site [chemical binding]; other site
365659005153	Uncharacterized homolog of plant Iojap protein [Function unknown]; Region: COG0799
365659005154	Isochorismatase family; Region: Isochorismatase; pfam00857
365659005155	Nicotinamidase_ related amidohydrolases.  Cysteine hydrolases of unknown function that share the catalytic triad with other amidohydrolases, like nicotinamidase, which converts nicotinamide to nicotinic acid and ammonia; Region: nicotinamidase_related; cd01014
365659005156	catalytic triad [active]
365659005157	conserved cis-peptide bond; other site
365659005158	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
365659005159	Zn2+ binding site [ion binding]; other site
365659005160	Mg2+ binding site [ion binding]; other site
365659005161	nicotinic acid mononucleotide adenylyltransferase; Provisional; Region: nadD; PRK00071
365659005162	Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165
365659005163	active site
365659005164	(T/H)XGH motif; other site
365659005165	Predicted RNA-binding protein containing KH domain, possibly ribosomal protein [Translation, ribosomal structure and biogenesis]; Region: COG1534
365659005166	GTPase YqeH; Provisional; Region: PRK13796
365659005167	Circularly permuted YqeH GTPase; Region: YqeH; cd01855
365659005168	GTP/Mg2+ binding site [chemical binding]; other site
365659005169	G4 box; other site
365659005170	G5 box; other site
365659005171	G1 box; other site
365659005172	Switch I region; other site
365659005173	G2 box; other site
365659005174	G3 box; other site
365659005175	Switch II region; other site
365659005176	Predicted hydrolase of the HAD superfamily [General function prediction only]; Region: COG2179
365659005177	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
365659005178	active site
365659005179	motif I; other site
365659005180	motif II; other site
365659005181	Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598
365659005182	uncharacterized bacterial subfamily of the Escherichia coli CorA-Salmonella typhimurium ZntB family; Region: EcCorA_ZntB-like_u2; cd12827
365659005183	Cl binding site [ion binding]; other site
365659005184	oligomer interface [polypeptide binding]; other site
365659005185	Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668
365659005186	Mechanosensitive ion channel; Region: MS_channel; pfam00924
365659005187	serine/threonine transporter SstT; Provisional; Region: PRK13628
365659005188	Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301
365659005189	Predicted membrane protein [Function unknown]; Region: COG4129
365659005190	Bacterial protein of unknown function (DUF939); Region: DUF939; pfam06081
365659005191	DUF939 C-terminal domain; Region: DUF939_C; pfam11728
365659005192	accessory Sec system glycosyltransferase GtfB; Region: TIGR02919
365659005193	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
365659005194	accessory Sec system glycosylation protein GtfA; Region: TIGR02918
365659005195	This family is most closely related to the GT1 family of glycosyltransferases and is named after gtfA in Streptococcus gordonii, where it plays a role in the O-linked glycosylation of GspB, a cell surface glycoprotein involved in platelet binding.  In...; Region: GT1_gtfA_like; cd04949
365659005196	preprotein translocase subunit SecA; Reviewed; Region: PRK09200
365659005197	SecA preprotein cross-linking domain; Region: SecA_PP_bind; pfam01043
365659005198	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cl17351
365659005199	nucleotide binding region [chemical binding]; other site
365659005200	ATP-binding site [chemical binding]; other site
365659005201	accessory Sec system protein Asp3; Region: acc_sec_asp3; TIGR03711
365659005202	accessory Sec system protein Asp2; Region: acc_sec_asp2; TIGR03712
365659005203	accessory Sec system protein Asp1; Region: acc_sec_asp1; TIGR03713
365659005204	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
365659005205	preprotein translocase subunit SecY; Reviewed; Region: secY; PRK12417
365659005206	SecY translocase; Region: SecY; pfam00344
365659005207	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761
365659005208	active site
365659005209	Lipopolysaccharide biosynthesis proteins, LPS:glycosyltransferases [Cell envelope biogenesis, outer membrane]; Region: RfaJ; COG1442
365659005210	A4GalT_like proteins catalyze the addition of galactose or glucose residues to the lipooligosaccharide (LOS) or lipopolysaccharide (LPS) of the bacterial cell surface; Region: GT8_A4GalT_like; cd04194
365659005211	Ligand binding site; other site
365659005212	metal-binding site
365659005213	Lipopolysaccharide biosynthesis proteins, LPS:glycosyltransferases [Cell envelope biogenesis, outer membrane]; Region: RfaJ; COG1442
365659005214	A4GalT_like proteins catalyze the addition of galactose or glucose residues to the lipooligosaccharide (LOS) or lipopolysaccharide (LPS) of the bacterial cell surface; Region: GT8_A4GalT_like; cd04194
365659005215	Ligand binding site; other site
365659005216	metal-binding site
365659005217	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761
365659005218	active site
365659005219	A4GalT_like proteins catalyze the addition of galactose or glucose residues to the lipooligosaccharide (LOS) or lipopolysaccharide (LPS) of the bacterial cell surface; Region: GT8_A4GalT_like; cd04194
365659005220	Glycosyl transferase family 8; Region: Glyco_transf_8; pfam01501
365659005221	Ligand binding site; other site
365659005222	metal-binding site
365659005223	glycosyltransferase, SP_1767 family; Region: glyco_access_1; TIGR03728
365659005224	beta-1,6-galactofuranosyltransferase; Provisional; Region: PRK09814
365659005225	Acetyltransferase (isoleucine patch superfamily) [General function prediction only]; Region: WbbJ; COG0110
365659005226	Maltose O-acyltransferase (MAT)-like: This family is composed of maltose O-acetyltransferase, galactoside O-acetyltransferase (GAT), xenobiotic acyltransferase (XAT) and similar proteins. MAT and GAT catalyze the CoA-dependent acetylation of the...; Region: LbH_MAT_like; cd04647
365659005227	trimer interface [polypeptide binding]; other site
365659005228	active site
365659005229	substrate binding site [chemical binding]; other site
365659005230	CoA binding site [chemical binding]; other site
365659005231	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
365659005232	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761
365659005233	active site
365659005234	Lipopolysaccharide biosynthesis proteins, LPS:glycosyltransferases [Cell envelope biogenesis, outer membrane]; Region: RfaJ; COG1442
365659005235	A4GalT_like proteins catalyze the addition of galactose or glucose residues to the lipooligosaccharide (LOS) or lipopolysaccharide (LPS) of the bacterial cell surface; Region: GT8_A4GalT_like; cd04194
365659005236	Ligand binding site; other site
365659005237	metal-binding site
365659005238	KxYKxGKxW signal peptide; Region: KxYKxGKxW; TIGR03715
365659005239	serine-rich repeat adhesion glycoprotein AST domain; Region: ser_adhes_Nterm; TIGR04224
365659005240	Gram positive anchor; Region: Gram_pos_anchor; pfam00746
365659005241	peptide chain release factor 3; Provisional; Region: prfC; PRK00741
365659005242	Release Factor 3 (RF3) protein involved in the terminal step of translocation in bacteria; Region: RF3; cd04169
365659005243	G1 box; other site
365659005244	putative GEF interaction site [polypeptide binding]; other site
365659005245	GTP/Mg2+ binding site [chemical binding]; other site
365659005246	Switch I region; other site
365659005247	G2 box; other site
365659005248	G3 box; other site
365659005249	Switch II region; other site
365659005250	G4 box; other site
365659005251	G5 box; other site
365659005252	RF3_II: this subfamily represents the domain II of bacterial Release Factor 3 (RF3). Termination of protein synthesis by the ribosome requires two release factor (RF) classes. The class II RF3 is a GTPase that removes class I RFs (RF1 or RF2) from the...; Region: RF3_II; cd03689
365659005253	aspartyl/glutamyl-tRNA amidotransferase subunit C; Reviewed; Region: gatC; PRK00034
365659005254	Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154
365659005255	aspartyl/glutamyl-tRNA amidotransferase subunit A; Reviewed; Region: gatA; PRK00012
365659005256	aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477
365659005257	GatB/GatE catalytic domain; Region: GatB_N; pfam02934
365659005258	GatB domain; Region: GatB_Yqey; pfam02637
365659005259	elongation factor P; Validated; Region: PRK00529
365659005260	Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207
365659005261	S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470
365659005262	RNA binding site [nucleotide binding]; other site
365659005263	S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794
365659005264	RNA binding site [nucleotide binding]; other site
365659005265	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1302
365659005266	transcription antitermination protein NusB; Reviewed; Region: nusB; PRK00202
365659005267	putative RNA binding site [nucleotide binding]; other site
365659005268	CAAX protease self-immunity; Region: Abi; pfam02517
365659005269	acetyl-CoA carboxylase subunit alpha; Provisional; Region: PRK12319
365659005270	acetyl-CoA carboxylase subunit beta; Validated; Region: PRK05654
365659005271	Uncharacterized protein family UPF0547; Region: UPF0547; pfam10571
365659005272	malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682
365659005273	acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591
365659005274	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
365659005275	Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786
365659005276	Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878
365659005277	FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288
365659005278	acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated; Region: PRK06302
365659005279	The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850
365659005280	carboxyltransferase (CT) interaction site; other site
365659005281	biotinylation site [posttranslational modification]; other site
365659005282	3-oxoacyl-(acyl carrier protein) synthase II; Reviewed; Region: PRK07314
365659005283	Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834
365659005284	dimer interface [polypeptide binding]; other site
365659005285	active site
365659005286	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557
365659005287	beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333
365659005288	NAD(P) binding site [chemical binding]; other site
365659005289	homotetramer interface [polypeptide binding]; other site
365659005290	homodimer interface [polypeptide binding]; other site
365659005291	active site
365659005292	(acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331
365659005293	malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128
365659005294	putative enoyl-[acyl-carrier-protein] reductase II; Region: enACPred_II; TIGR03151
365659005295	2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730
365659005296	FMN binding site [chemical binding]; other site
365659005297	substrate binding site [chemical binding]; other site
365659005298	putative catalytic residue [active]
365659005299	acyl carrier protein; Provisional; Region: acpP; PRK00982
365659005300	3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352
365659005301	Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830
365659005302	dimer interface [polypeptide binding]; other site
365659005303	active site
365659005304	CoA binding pocket [chemical binding]; other site
365659005305	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
365659005306	MarR family; Region: MarR_2; pfam12802
365659005307	enoyl-CoA hydratase; Provisional; Region: PRK07260
365659005308	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
365659005309	substrate binding site [chemical binding]; other site
365659005310	oxyanion hole (OAH) forming residues; other site
365659005311	trimer interface [polypeptide binding]; other site
365659005312	aspartate kinase; Reviewed; Region: PRK09034
365659005313	AAK_AKiii-YclM-BS: Amino Acid Kinase Superfamily (AAK), AKiii-YclM-BS; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the lysine plus threonine-sensitive aspartokinase isoenzyme AKIII, a monofunctional class enzyme found in...; Region: AAK_AKiii-YclM-BS; cd04245
365659005314	putative catalytic residues [active]
365659005315	putative nucleotide binding site [chemical binding]; other site
365659005316	putative aspartate binding site [chemical binding]; other site
365659005317	ACT domains located C-terminal to the catalytic domain of the lysine plus threonine-sensitive aspartokinase isoenzyme AKIII; Region: ACT_AKiii-YclM-BS_1; cd04911
365659005318	allosteric regulatory residue; other site
365659005319	ACT domains located C-terminal to the catalytic domain of the lysine plus threonine-sensitive aspartokinase isoenzyme AKIII; Region: ACT_AKiii-YclM-BS_2; cd04916
365659005320	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4687
365659005321	seryl-tRNA synthetase; Provisional; Region: PRK05431
365659005322	Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403
365659005323	Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770
365659005324	dimer interface [polypeptide binding]; other site
365659005325	active site
365659005326	motif 1; other site
365659005327	motif 2; other site
365659005328	motif 3; other site
365659005329	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464
365659005330	Transposase; Region: DDE_Tnp_ISL3; pfam01610
365659005331	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
365659005332	DNA-binding site [nucleotide binding]; DNA binding site
365659005333	DDE superfamily endonuclease; Region: DDE_4_2; pfam13613
365659005334	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3293
365659005335	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
365659005336	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
365659005337	N-acetyl-D-glucosamine binding site [chemical binding]; other site
365659005338	catalytic residue [active]
365659005339	NlpC/P60 family; Region: NLPC_P60; pfam00877
365659005340	Conjugative transposon protein TcpC; Region: TpcC; pfam12642
365659005341	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
365659005342	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
365659005343	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
365659005344	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
365659005345	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
365659005346	Walker A/P-loop; other site
365659005347	ATP binding site [chemical binding]; other site
365659005348	Q-loop/lid; other site
365659005349	ABC transporter signature motif; other site
365659005350	Walker B; other site
365659005351	D-loop; other site
365659005352	H-loop/switch region; other site
365659005353	Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cl02788
365659005354	catalytic nucleophile [active]
365659005355	RibD C-terminal domain; Region: RibD_C; cl17279
365659005356	Acetyltransferase (GNAT) domain; Region: Acetyltransf_8; pfam13523
365659005357	Siderophore biosynthesis protein domain; Region: AlcB; smart01006
365659005358	Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583
365659005359	Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120
365659005360	Phosphotransferase enzyme family; Region: APH; pfam01636
365659005361	active site
365659005362	ATP binding site [chemical binding]; other site
365659005363	Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270
365659005364	substrate binding site [chemical binding]; other site
365659005365	Acetyltransferases [General function prediction only]; Region: RimI; COG0456
365659005366	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
365659005367	Coenzyme A binding pocket [chemical binding]; other site
365659005368	WYL domain; Region: WYL; pfam13280
365659005369	HTH domain; Region: HTH_11; pfam08279
365659005370	Aminoglycoside 3'-phosphotransferase (APH). The APH subfamily is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs), RIO kinases, actin-fragmin...; Region: APH; cd05150
365659005371	active site
365659005372	ATP binding site [chemical binding]; other site
365659005373	Phosphotransferase enzyme family; Region: APH; pfam01636
365659005374	antibiotic binding site [chemical binding]; other site
365659005375	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
365659005376	Acetyltransferases [General function prediction only]; Region: RimI; COG0456
365659005377	Coenzyme A binding pocket [chemical binding]; other site
365659005378	Streptomycin adenylyltransferase; Region: Adenyl_transf; pfam04439
365659005379	Methyltransferase domain; Region: Methyltransf_31; pfam13847
365659005380	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
365659005381	S-adenosylmethionine binding site [chemical binding]; other site
365659005382	Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403
365659005383	active site
365659005384	NTP binding site [chemical binding]; other site
365659005385	metal binding triad [ion binding]; metal-binding site
365659005386	Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961
365659005387	Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338
365659005388	catalytic residues [active]
365659005389	catalytic nucleophile [active]
365659005390	Recombinase; Region: Recombinase; pfam07508
365659005391	Recombinase zinc beta ribbon domain; Region: Zn_ribbon_recom; pfam13408
365659005392	Recombinase; Region: Recombinase; pfam07508
365659005393	COG1961
365659005394	ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555
365659005395	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
365659005396	Walker A/P-loop; other site
365659005397	ATP binding site [chemical binding]; other site
365659005398	Q-loop/lid; other site
365659005399	ABC transporter signature motif; other site
365659005400	Walker B; other site
365659005401	D-loop; other site
365659005402	H-loop/switch region; other site
365659005403	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
365659005404	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
365659005405	Tellurite resistance protein and related permeases [Inorganic ion transport and metabolism]; Region: TehA; COG1275
365659005406	C4-dicarboxylate transporters of the Tellurite-resistance/Dicarboxylate Transporter (TDT) family; Region: TDT_C4-dicarb_trans; cd09325
365659005407	gating phenylalanine in ion channel; other site
365659005408	Uncharacterized conserved protein [Function unknown]; Region: COG2128
365659005409	Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627
365659005410	Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115
365659005411	amino acid carrier protein; Region: agcS; TIGR00835
365659005412	FOG: Glucan-binding domain (YG repeat) [General function prediction only]; Region: COG5263
365659005413	FOG: Glucan-binding domain (YG repeat) [General function prediction only]; Region: COG5263
365659005414	Nuclease-related domain; Region: NERD; pfam08378
365659005415	GrpE; Region: GrpE; pfam01025
365659005416	GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446
365659005417	hsp70 (ATPase domain) interactions [polypeptide binding]; other site
365659005418	DnaJ domain; Region: DnaJ; pfam00226
365659005419	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
365659005420	binding surface
365659005421	TPR motif; other site
365659005422	TPR repeat; Region: TPR_11; pfam13414
365659005423	rod-share determining protein MreBH; Provisional; Region: PRK13929
365659005424	Nucleotide-binding domain of the HSP70 family; Region: HSP70_NBD; cd10170
365659005425	nucleotide binding site [chemical binding]; other site
365659005426	putative NEF/HSP70 interaction site [polypeptide binding]; other site
365659005427	SBD interface [polypeptide binding]; other site
365659005428	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
365659005429	non-specific DNA binding site [nucleotide binding]; other site
365659005430	salt bridge; other site
365659005431	sequence-specific DNA binding site [nucleotide binding]; other site
365659005432	Mismatch repair ATPase (MutS family) [DNA replication, recombination, and repair]; Region: COG1193
365659005433	MutS domain III; Region: MutS_III; pfam05192
365659005434	ATP-binding cassette domain of MutS2; Region: ABC_MutS2; cd03280
365659005435	Walker A/P-loop; other site
365659005436	ATP binding site [chemical binding]; other site
365659005437	Q-loop/lid; other site
365659005438	ABC transporter signature motif; other site
365659005439	Walker B; other site
365659005440	D-loop; other site
365659005441	H-loop/switch region; other site
365659005442	Smr domain; Region: Smr; pfam01713
365659005443	Uncharacterized membrane protein, required for colicin V production [General function prediction only]; Region: CvpA; COG1286
365659005444	Colicin V production protein; Region: Colicin_V; pfam02674
365659005445	ribonuclease HIII; Provisional; Region: PRK00996
365659005446	Domain of unknown function (DUF3378); Region: DUF3378; pfam11858
365659005447	bacterial Ribonuclease HIII-like; Region: RNase_HII_bacteria_HIII_like; cd06590
365659005448	RNA/DNA hybrid binding site [nucleotide binding]; other site
365659005449	active site
365659005450	signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227
365659005451	The S24, S26 LexA/signal peptidase superfamily contains LexA-related and type I signal peptidase families. The S24 LexA protein domains include: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC 3.4.21.88), the...; Region: Peptidase_S24_S26; cd06462
365659005452	Catalytic site [active]
365659005453	The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530
365659005454	helicase, putative, RecD/TraA family; Region: recD_rel; TIGR01448
365659005455	H3TH domains of structure-specific 5' nucleases (or flap endonuclease-1-like) involved in DNA replication, repair, and recombination; Region: H3TH_StructSpec-5'-nucleases; cl14815
365659005456	DNA binding site [nucleotide binding]
365659005457	AAA domain; Region: AAA_30; pfam13604
365659005458	Family description; Region: UvrD_C_2; pfam13538
365659005459	trigger factor; Provisional; Region: tig; PRK01490
365659005460	FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254
365659005461	Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698
365659005462	A new structural DNA glycosylase; Region: AlkD_like; cl11434
365659005463	DNA alkylation repair enzyme; Region: DNA_alkylation; pfam08713
365659005464	active site
365659005465	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
365659005466	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
365659005467	active site
365659005468	phosphorylation site [posttranslational modification]
365659005469	intermolecular recognition site; other site
365659005470	dimerization interface [polypeptide binding]; other site
365659005471	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
365659005472	DNA binding residues [nucleotide binding]
365659005473	dimerization interface [polypeptide binding]; other site
365659005474	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585
365659005475	Histidine kinase; Region: HisKA_3; pfam07730
365659005476	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
365659005477	ATP binding site [chemical binding]; other site
365659005478	Mg2+ binding site [ion binding]; other site
365659005479	G-X-G motif; other site
365659005480	Predicted membrane protein [Function unknown]; Region: COG4758
365659005481	Cell wall-active antibiotics response protein (DUF2154); Region: DUF2154; pfam09922
365659005482	isopentenyl pyrophosphate isomerase; Provisional; Region: PRK05437
365659005483	Isopentenyl-diphosphate:dimethylallyl diphosphate isomerase type 2 (IDI-2) FMN-binding domain. Two types of IDIs have been characterized at present. The long known IDI-1 is only dependent on divalent metals for activity, whereas IDI-2 requires a metal; Region: IDI-2_FMN; cd02811
365659005484	homotetramer interface [polypeptide binding]; other site
365659005485	FMN binding site [chemical binding]; other site
365659005486	homodimer contacts [polypeptide binding]; other site
365659005487	putative active site [active]
365659005488	putative substrate binding site [chemical binding]; other site
365659005489	Mevalonate kinase [Lipid metabolism]; Region: ERG12; COG1577
365659005490	GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544
365659005491	Mevalonate pyrophosphate decarboxylase [Lipid metabolism]; Region: MVD1; COG3407
365659005492	diphosphomevalonate decarboxylase; Region: PLN02407
365659005493	Mevalonate kinase [Lipid metabolism]; Region: ERG12; COG1577
365659005494	GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288
365659005495	GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544
365659005496	FOG: Glucan-binding domain (YG repeat) [General function prediction only]; Region: COG5263
365659005497	Putative cell wall binding repeat; Region: CW_binding_1; pfam01473
365659005498	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
365659005499	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
365659005500	active site
365659005501	phosphorylation site [posttranslational modification]
365659005502	intermolecular recognition site; other site
365659005503	dimerization interface [polypeptide binding]; other site
365659005504	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
365659005505	DNA binding site [nucleotide binding]
365659005506	6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599
365659005507	6-phosphogluconate dehydrogenase; Validated; Region: PRK09287
365659005508	6-phosphogluconate dehydrogenase, C-terminal domain; Region: 6PGD; pfam00393
365659005509	Predicted N6-adenine-specific DNA methylase [DNA replication, recombination, and repair]; Region: COG0116
365659005510	THUMP domain associated with S-adenosylmethionine-dependent methyltransferases; Region: THUMP_AdoMetMT; cd11715
365659005511	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173
365659005512	cell division protein GpsB; Provisional; Region: PRK14127
365659005513	DivIVA domain; Region: DivI1A_domain; TIGR03544
365659005514	hypothetical protein; Provisional; Region: PRK13660
365659005515	Holliday junction-specific endonuclease; Reviewed; Region: recU; PRK02234
365659005516	Transglycosylase; Region: Transgly; pfam00912
365659005517	penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074
365659005518	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760
365659005519	ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166
365659005520	The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504
365659005521	peptide binding site [polypeptide binding]; other site
365659005522	UDP-galactopyranose mutase [Cell envelope biogenesis, outer membrane]; Region: Glf; COG0562
365659005523	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
365659005524	UDP-galactopyranose mutase; Region: GLF; pfam03275
365659005525	authentic stop codons
365659005526	alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403
365659005527	Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333
365659005528	Ca binding site [ion binding]; other site
365659005529	active site
365659005530	catalytic site [active]
365659005531	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4868
365659005532	hypothetical protein; Provisional; Region: PRK13663
365659005533	LuxS protein involved in autoinducer AI2 synthesis [Signal transduction mechanisms]; Region: LuxS; COG1854
365659005534	RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651
365659005535	Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078
365659005536	putative active site [active]
365659005537	putative NTP binding site [chemical binding]; other site
365659005538	putative nucleic acid binding site [nucleotide binding]; other site
365659005539	Group II intron, maturase-specific domain; Region: GIIM; pfam08388
365659005540	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
365659005541	ATPases associated with a variety of cellular activities; Region: AAA; smart00382
365659005542	Walker A motif; other site
365659005543	ATP binding site [chemical binding]; other site
365659005544	Walker B motif; other site
365659005545	arginine finger; other site
365659005546	UvrB/uvrC motif; Region: UVR; pfam02151
365659005547	MoxR-like ATPases [General function prediction only]; Region: COG0714
365659005548	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
365659005549	Walker A motif; other site
365659005550	ATP binding site [chemical binding]; other site
365659005551	Walker B motif; other site
365659005552	arginine finger; other site
365659005553	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431
365659005554	phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108
365659005555	Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852
365659005556	Mg++ binding site [ion binding]; other site
365659005557	putative catalytic motif [active]
365659005558	putative substrate binding site [chemical binding]; other site
365659005559	Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768
365659005560	Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717
365659005561	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905
365659005562	PASTA domain of PBP2x-like proteins, first repeat. Penicillin-binding proteins (PBPs) are the major targets for beta-lactam antibiotics, like penicillins and cephalosporins. Beta-lactam antibiotics specifically inhibit transpeptidase activity by...; Region: PASTA_Pbp2x-like_1; cd06576
365659005563	PASTA domain of PBP2x-like proteins, second repeat. Penicillin-binding proteins (PBPs) are the major targets for beta-lactam antibiotics, like penicillins and cephalosporins. Beta-lactam antibiotics specifically inhibit transpeptidase activity by...; Region: PASTA_Pbp2x-like_2; cd06575
365659005564	Protein required for the initiation of cell division [Cell division and chromosome partitioning]; Region: FtsL; COG4839
365659005565	Predicted S-adenosylmethionine-dependent methyltransferase involved in cell envelope biogenesis [Cell envelope biogenesis, outer membrane]; Region: COG0275
365659005566	MraW methylase family; Region: Methyltransf_5; pfam01795
365659005567	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
365659005568	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
365659005569	non-specific DNA binding site [nucleotide binding]; other site
365659005570	salt bridge; other site
365659005571	sequence-specific DNA binding site [nucleotide binding]; other site
365659005572	Protein of unknown function (DUF3278); Region: DUF3278; pfam11683
365659005573	Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per...; Region: GSH_Peroxidase; cd00340
365659005574	catalytic residues [active]
365659005575	dimer interface [polypeptide binding]; other site
365659005576	YolD-like protein; Region: YolD; pfam08863
365659005577	DNA polymerase IV; Reviewed; Region: PRK03103
365659005578	umuC subunit of DNA Polymerase V; Region: PolY_Pol_V_umuC; cd01700
365659005579	active site
365659005580	DNA binding site [nucleotide binding]
365659005581	SOS-response transcriptional repressors (RecA-mediated autopeptidases) [Transcription / Signal transduction mechanisms]; Region: LexA; COG1974
365659005582	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
365659005583	sequence-specific DNA binding site [nucleotide binding]; other site
365659005584	salt bridge; other site
365659005585	Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529
365659005586	Catalytic site [active]
365659005587	amino acid/peptide transporter (Peptide:H+ symporter), bacterial; Region: yjdL_sub1_fam; TIGR00924
365659005588	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
365659005589	Predicted ATPase (AAA+ superfamily) [General function prediction only]; Region: COG1373
365659005590	AAA domain; Region: AAA_14; pfam13173
365659005591	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
365659005592	Predicted transcriptional regulators [Transcription]; Region: COG1733
365659005593	HxlR-like helix-turn-helix; Region: HxlR; pfam01638
365659005594	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
365659005595	Major Facilitator Superfamily; Region: MFS_1; pfam07690
365659005596	putative substrate translocation pore; other site
365659005597	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cl17904
365659005598	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
365659005599	DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674
365659005600	FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580
365659005601	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
365659005602	phosphoprotein phosphatases of the metallophosphatase superfamily, metallophosphatase domain; Region: MPP_PPP_family; cd00144
365659005603	active site
365659005604	metal binding site [ion binding]; metal-binding site
365659005605	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
365659005606	metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995
365659005607	active site
365659005608	metal binding site [ion binding]; metal-binding site
365659005609	putative replication initiation protein; Region: PHA00330
365659005610	Helix-turn-helix domain; Region: HTH_17; pfam12728
365659005611	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
365659005612	active site
365659005613	DNA binding site [nucleotide binding]
365659005614	Int/Topo IB signature motif; other site
365659005615	30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132
365659005616	Ribosomal protein L13.  Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392
365659005617	23S rRNA interface [nucleotide binding]; other site
365659005618	L3 interface [polypeptide binding]; other site
365659005619	Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826
365659005620	Helix-turn-helix domain; Region: HTH_38; pfam13936
365659005621	Integrase core domain; Region: rve; pfam00665
365659005622	ABC-type Na+ efflux pump, permease component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatB; COG1668
365659005623	ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: COG4152
365659005624	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
365659005625	Walker A/P-loop; other site
365659005626	ATP binding site [chemical binding]; other site
365659005627	Q-loop/lid; other site
365659005628	ABC transporter signature motif; other site
365659005629	Walker B; other site
365659005630	D-loop; other site
365659005631	H-loop/switch region; other site
365659005632	Domain of unknown function (DUF4162); Region: DUF4162; pfam13732
365659005633	phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629
365659005634	tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain.  PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796
365659005635	putative tRNA-binding site [nucleotide binding]; other site
365659005636	B3/4 domain; Region: B3_4; pfam03483
365659005637	tRNA synthetase B5 domain; Region: B5; smart00874
365659005638	Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA,  PheRS is an...; Region: PheRS_beta_core; cd00769
365659005639	dimer interface [polypeptide binding]; other site
365659005640	motif 1; other site
365659005641	motif 3; other site
365659005642	motif 2; other site
365659005643	Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; smart00896
365659005644	Interleukin 2; Region: IL2; cl11593
365659005645	phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488
365659005646	Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912
365659005647	Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496
365659005648	dimer interface [polypeptide binding]; other site
365659005649	motif 1; other site
365659005650	active site
365659005651	motif 2; other site
365659005652	motif 3; other site
365659005653	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
365659005654	Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583
365659005655	ParB-like nuclease domain; Region: ParBc; cl02129
365659005656	PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392
365659005657	Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671
365659005658	active site
365659005659	Predicted membrane protein [Function unknown]; Region: COG3601
365659005660	Protein of unknown function (DUF3816); Region: DUF3816; pfam12822
365659005661	Predicted rRNA methylase (SpoU class) [Translation, ribosomal structure and biogenesis]; Region: CspR; COG0219
365659005662	ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619
365659005663	ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122
365659005664	First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225
365659005665	Walker A/P-loop; other site
365659005666	ATP binding site [chemical binding]; other site
365659005667	Q-loop/lid; other site
365659005668	ABC transporter signature motif; other site
365659005669	Walker B; other site
365659005670	D-loop; other site
365659005671	H-loop/switch region; other site
365659005672	ATP-binding cassette cobalt transporter; Region: DUF3744; pfam12558
365659005673	ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122
365659005674	First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225
365659005675	Walker A/P-loop; other site
365659005676	ATP binding site [chemical binding]; other site
365659005677	Q-loop/lid; other site
365659005678	ABC transporter signature motif; other site
365659005679	Walker B; other site
365659005680	D-loop; other site
365659005681	H-loop/switch region; other site
365659005682	hypothetical protein; Provisional; Region: PRK13661
365659005683	Uncharacterized conserved protein [Function unknown]; Region: COG1912
365659005684	potassium transporter peripheral membrane component; Reviewed; Region: trkA; PRK09496
365659005685	TrkA-N domain; Region: TrkA_N; pfam02254
365659005686	TrkA-C domain; Region: TrkA_C; pfam02080
365659005687	TrkA-N domain; Region: TrkA_N; pfam02254
365659005688	TrkA-C domain; Region: TrkA_C; pfam02080
365659005689	Trk-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: TrkG; COG0168
365659005690	potassium uptake protein, TrkH family; Region: 2a38; TIGR00933
365659005691	formate acetyltransferase 1; Region: pyr_form_ly_1; TIGR01255
365659005692	Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939
365659005693	DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586
365659005694	active site
365659005695	DNA polymerase IV; Validated; Region: PRK02406
365659005696	DNA binding site [nucleotide binding]
365659005697	undecaprenyl pyrophosphate phosphatase; Reviewed; Region: PRK00281
365659005698	Predicted membrane protein (DUF2207); Region: DUF2207; pfam09972
365659005699	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
365659005700	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
365659005701	substrate binding pocket [chemical binding]; other site
365659005702	membrane-bound complex binding site; other site
365659005703	hinge residues; other site
365659005704	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
365659005705	dimer interface [polypeptide binding]; other site
365659005706	conserved gate region; other site
365659005707	putative PBP binding loops; other site
365659005708	ABC-ATPase subunit interface; other site
365659005709	ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126
365659005710	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
365659005711	Walker A/P-loop; other site
365659005712	ATP binding site [chemical binding]; other site
365659005713	Q-loop/lid; other site
365659005714	ABC transporter signature motif; other site
365659005715	Walker B; other site
365659005716	D-loop; other site
365659005717	H-loop/switch region; other site
365659005718	threonine dehydratase; Validated; Region: PRK08639
365659005719	Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562
365659005720	tetramer interface [polypeptide binding]; other site
365659005721	pyridoxal 5'-phosphate binding site [chemical binding]; other site
365659005722	catalytic residue [active]
365659005723	C-terminal regulatory domain of Threonine dehydratase; Region: Thr_dehydrat_C; pfam00585
365659005724	ketol-acid reductoisomerase; Provisional; Region: PRK05479
365659005725	Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvN; pfam07991
365659005726	Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450
365659005727	acetolactate synthase 3 regulatory subunit; Reviewed; Region: ilvH; PRK11895
365659005728	N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878
365659005729	putative valine binding site [chemical binding]; other site
365659005730	dimer interface [polypeptide binding]; other site
365659005731	Small subunit of acetolactate synthase; Region: ALS_ss_C; pfam10369
365659005732	acetolactate synthase catalytic subunit; Reviewed; Region: PRK07282
365659005733	Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035
365659005734	PYR/PP interface [polypeptide binding]; other site
365659005735	dimer interface [polypeptide binding]; other site
365659005736	TPP binding site [chemical binding]; other site
365659005737	Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205
365659005738	Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015
365659005739	TPP-binding site [chemical binding]; other site
365659005740	dimer interface [polypeptide binding]; other site
365659005741	Predicted kinase related to dihydroxyacetone kinase [General function prediction only]; Region: COG1461
365659005742	DAK2 domain; Region: Dak2; pfam02734
365659005743	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1302
365659005744	50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359
365659005745	Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826
365659005746	Helix-turn-helix domain; Region: HTH_38; pfam13936
365659005747	Integrase core domain; Region: rve; pfam00665
365659005748	Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826
365659005749	Helix-turn-helix domain; Region: HTH_38; pfam13936
365659005750	Integrase core domain; Region: rve; pfam00665
365659005751	Cell wall-active antibiotics response protein (DUF2154); Region: DUF2154; pfam09922
365659005752	Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279
365659005753	LytTr DNA-binding domain; Region: LytTR; smart00850
365659005754	PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cd01610
365659005755	Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671
365659005756	active site
365659005757	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
365659005758	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
365659005759	ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254
365659005760	Walker A/P-loop; other site
365659005761	ATP binding site [chemical binding]; other site
365659005762	Q-loop/lid; other site
365659005763	ABC transporter signature motif; other site
365659005764	Walker B; other site
365659005765	D-loop; other site
365659005766	H-loop/switch region; other site
365659005767	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
365659005768	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
365659005769	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
365659005770	Walker A/P-loop; other site
365659005771	ATP binding site [chemical binding]; other site
365659005772	Q-loop/lid; other site
365659005773	ABC transporter signature motif; other site
365659005774	Walker B; other site
365659005775	D-loop; other site
365659005776	H-loop/switch region; other site
365659005777	Winged helix DNA-binding domain; Region: HTH_27; pfam13463
365659005778	Transcriptional regulators [Transcription]; Region: MarR; COG1846
365659005779	hypothetical protein; Provisional; Region: PRK12378
365659005780	Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534
365659005781	Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Bacillus subtilis yoeA; Region: MATE_yoeA_like; cd13138
365659005782	recombinase A; Provisional; Region: recA; PRK09354
365659005783	RecA is a  bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response.  RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983
365659005784	hexamer interface [polypeptide binding]; other site
365659005785	Walker A motif; other site
365659005786	ATP binding site [chemical binding]; other site
365659005787	Walker B motif; other site
365659005788	competence damage-inducible protein A; Provisional; Region: PRK00549
365659005789	Competence-damaged protein. CinA is the first gene in the competence- inducible (cin) operon and is thought to be specifically required at some stage in the process of transformation. This domain is closely related to a domain, found in a variety of...; Region: cinA; cd00885
365659005790	putative MPT binding site; other site
365659005791	Uncharacterized protein (competence- and mitomycin-induced) [General function prediction only]; Region: CinA; COG1546
365659005792	Transcriptional regulator [Transcription]; Region: LytR; COG1316
365659005793	Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670
365659005794	Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583
365659005795	Predicted ATPase or kinase [General function prediction only]; Region: COG0802
365659005796	Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413
365659005797	active site
365659005798	multimer interface [polypeptide binding]; other site
365659005799	DNA-directed RNA polymerase subunit beta'; Provisional; Region: PRK00566
365659005800	RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997
365659005801	RNA polymerase I subunit A N-terminus; Region: RPOLA_N; smart00663
365659005802	RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983
365659005803	RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000
365659005804	Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655
365659005805	Rpb1 (beta') - Rpb6 (omega) interaction site [polypeptide binding]; other site
365659005806	G-loop; other site
365659005807	Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655
365659005808	DNA binding site [nucleotide binding]
365659005809	Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site
365659005810	DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405
365659005811	RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585
365659005812	RNA polymerase Rpb2, domain 2; Region: RNA_pol_Rpb2_2; pfam04561
365659005813	RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585
365659005814	RNA polymerase beta subunit external 1 domain; Region: RNA_pol_Rpb2_45; pfam10385
365659005815	RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653
365659005816	RPB1 interaction site [polypeptide binding]; other site
365659005817	RPB10 interaction site [polypeptide binding]; other site
365659005818	RPB11 interaction site [polypeptide binding]; other site
365659005819	RPB3 interaction site [polypeptide binding]; other site
365659005820	RPB12 interaction site [polypeptide binding]; other site
365659005821	YSIRK type signal peptide; Region: YSIRK_signal; pfam04650
365659005822	pullulanase, extracellular, Gram-positive; Region: pullulan_Gpos; TIGR02102
365659005823	Family 41 Carbohydrate-Binding Module from pullulanase-like enzymes; Region: CBM41_pullulanase; cd10315
365659005824	carbohydrate binding site [chemical binding]; other site
365659005825	Family 41 Carbohydrate-Binding Module from pullulanase-like enzymes; Region: CBM41_pullulanase; cd10315
365659005826	carbohydrate binding site [chemical binding]; other site
365659005827	Early set domain associated with the catalytic domain of pullulanase (also called dextrinase and alpha-dextrin endo-1,6-alpha glucosidase); Region: E_set_Pullulanase; cd02860
365659005828	Alpha amylase catalytic domain found in Pullulanase (also called dextrinase; alpha-dextrin endo-1,6-alpha glucosidase), limit dextrinase, and related proteins; Region: AmyAc_Pullulanase_LD-like; cd11341
365659005829	Ca binding site [ion binding]; other site
365659005830	active site
365659005831	catalytic site [active]
365659005832	probable oxidoreductase, LLM family; Region: LLM_2I7G; TIGR03858
365659005833	Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases [Energy production and conversion]; Region: COG2141
365659005834	glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331
365659005835	Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans).  The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714
365659005836	glutaminase active site [active]
365659005837	SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008
365659005838	dimer interface [polypeptide binding]; other site
365659005839	active site
365659005840	SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009
365659005841	dimer interface [polypeptide binding]; other site
365659005842	active site
365659005843	Beta-glucosidase/6-phospho-beta-glucosidase/beta- galactosidase [Carbohydrate transport and metabolism]; Region: BglB; COG2723
365659005844	beta-galactosidase; Region: BGL; TIGR03356
365659005845	prolyl-tRNA synthetase; Provisional; Region: PRK09194
365659005846	Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_prok; cd00779
365659005847	dimer interface [polypeptide binding]; other site
365659005848	motif 1; other site
365659005849	active site
365659005850	motif 2; other site
365659005851	INS is an amino acid-editing domain inserted (INS) into the bacterial class II prolyl-tRNA synthetase (ProRS) however, this CD is not exclusively bacterial. It is also found at the N-terminus of the eukaryotic/archaea-like ProRS's of yeasts and...; Region: ProRS-INS; cd04334
365659005852	putative deacylase active site [active]
365659005853	Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA.   PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268
365659005854	active site
365659005855	motif 3; other site
365659005856	ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding; Region: ProRS_anticodon_short; cd00861
365659005857	anticodon binding site; other site
365659005858	RIP metalloprotease RseP; Region: TIGR00054
365659005859	RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163
365659005860	active site
365659005861	Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020
365659005862	PDZ domain, also called DHR (Dlg homologous region) or GLGF (after a conserved sequence motif). Many PDZ domains bind C-terminal polypeptides, though binding to internal (non-C-terminal) polypeptides and even to lipids has been demonstrated; Region: PDZ; cl00117
365659005863	protein binding site [polypeptide binding]; other site
365659005864	RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163
365659005865	putative substrate binding region [chemical binding]; other site
365659005866	CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575
365659005867	Cytidylyltransferase family; Region: CTP_transf_1; pfam01148
365659005868	Undecaprenyl pyrophosphate synthase [Lipid metabolism]; Region: UppS; COG0020
365659005869	Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cd00475
365659005870	catalytic residue [active]
365659005871	putative FPP diphosphate  binding site; other site
365659005872	putative FPP binding hydrophobic cleft; other site
365659005873	dimer interface [polypeptide binding]; other site
365659005874	putative IPP diphosphate binding site; other site
365659005875	Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826
365659005876	Helix-turn-helix domain; Region: HTH_38; pfam13936
365659005877	Integrase core domain; Region: rve; pfam00665
365659005878	Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826
365659005879	Helix-turn-helix domain; Region: HTH_38; pfam13936
365659005880	Integrase core domain; Region: rve; pfam00665
365659005881	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3575
365659005882	Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080
365659005883	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
365659005884	Walker A motif; other site
365659005885	ATP binding site [chemical binding]; other site
365659005886	Walker B motif; other site
365659005887	arginine finger; other site
365659005888	Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491
365659005889	Toxin Fst, type I toxin-antitoxin system; Region: Fst_toxin; pfam13955
365659005890	Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826
365659005891	Helix-turn-helix domain; Region: HTH_38; pfam13936
365659005892	Integrase core domain; Region: rve; pfam00665
365659005893	Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673
365659005894	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
365659005895	Coenzyme A binding pocket [chemical binding]; other site
365659005896	Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670
365659005897	Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583
365659005898	Protein of unknown function (DUF3021); Region: DUF3021; pfam11457
365659005899	LytTr DNA-binding domain; Region: LytTR; pfam04397
365659005900	ABC-2 type transporter; Region: ABC2_membrane; cl17235
365659005901	ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842
365659005902	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
365659005903	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
365659005904	Walker A/P-loop; other site
365659005905	ATP binding site [chemical binding]; other site
365659005906	Q-loop/lid; other site
365659005907	ABC transporter signature motif; other site
365659005908	Walker B; other site
365659005909	D-loop; other site
365659005910	H-loop/switch region; other site
365659005911	leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390
365659005912	catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812
365659005913	HIGH motif; other site
365659005914	Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603
365659005915	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
365659005916	active site
365659005917	KMSKS motif; other site
365659005918	Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958
365659005919	tRNA binding surface [nucleotide binding]; other site
365659005920	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
365659005921	catalytic core [active]
365659005922	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
365659005923	FOG: Glucan-binding domain (YG repeat) [General function prediction only]; Region: COG5263
365659005924	Uncharacterized proteins with similarity to Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL_like_DUF711; cd08025
365659005925	ACT domain proteins similar to the yet uncharacterized Streptococcus pneumoniae ACT domain protein; Region: ACT_1ZPV; cd04872
365659005926	50S ribosomal protein L17; Validated; Region: rplQ; PRK05591
365659005927	DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182
365659005928	N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928
365659005929	alphaNTD homodimer interface [polypeptide binding]; other site
365659005930	alphaNTD - beta interaction site [polypeptide binding]; other site
365659005931	alphaNTD - beta' interaction site [polypeptide binding]; other site
365659005932	Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118
365659005933	30S ribosomal protein S11; Validated; Region: PRK05309
365659005934	Ribosomal protein S13 [Translation, ribosomal structure and biogenesis]; Region: RpsM; COG0099
365659005935	30S ribosomal protein S13; Region: bact_S13; TIGR03631
365659005936	Ribosomal protein L36; Region: Ribosomal_L36; pfam00444
365659005937	S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451
365659005938	rRNA binding site [nucleotide binding]; other site
365659005939	predicted 30S ribosome binding site; other site
365659005940	adenylate kinase; Reviewed; Region: adk; PRK00279
365659005941	Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428
365659005942	AMP-binding site [chemical binding]; other site
365659005943	ATP-AMP (Ap5A)-binding site [chemical binding]; other site
365659005944	preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204
365659005945	SecY translocase; Region: SecY; pfam00344
365659005946	50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592
365659005947	Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins that...; Region: Ribosomal_L30; cd01658
365659005948	23S rRNA binding site [nucleotide binding]; other site
365659005949	30S ribosomal protein S5; Validated; Region: rpsE; PRK00550
365659005950	Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333
365659005951	Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719
365659005952	Ribosomal L18/L5e:  L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432
365659005953	5S rRNA interface [nucleotide binding]; other site
365659005954	L27 interface [polypeptide binding]; other site
365659005955	23S rRNA interface [nucleotide binding]; other site
365659005956	L5 interface [polypeptide binding]; other site
365659005957	50S ribosomal protein L6; Validated; Region: rplF; PRK05498
365659005958	Ribosomal protein L6; Region: Ribosomal_L6; pfam00347
365659005959	Ribosomal protein L6; Region: Ribosomal_L6; pfam00347
365659005960	30S ribosomal protein S8; Validated; Region: rpsH; PRK00136
365659005961	30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08061
365659005962	50S ribosomal protein L5; Validated; Region: rplE; PRK00010
365659005963	Ribosomal protein L5; Region: Ribosomal_L5; pfam00281
365659005964	ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673
365659005965	50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004
365659005966	KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089
365659005967	RNA binding site [nucleotide binding]; other site
365659005968	50S ribosomal protein L14; Validated; Region: rplN; PRK05483
365659005969	30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610
365659005970	Ribosomal L29 protein/HIP.  L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals.  L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427
365659005971	23S rRNA interface [nucleotide binding]; other site
365659005972	putative translocon interaction site; other site
365659005973	signal recognition particle (SRP54) interaction site; other site
365659005974	L23 interface [polypeptide binding]; other site
365659005975	trigger factor interaction site; other site
365659005976	Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433
365659005977	23S rRNA interface [nucleotide binding]; other site
365659005978	5S rRNA interface [nucleotide binding]; other site
365659005979	putative antibiotic binding site [chemical binding]; other site
365659005980	L25 interface [polypeptide binding]; other site
365659005981	L27 interface [polypeptide binding]; other site
365659005982	30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310
365659005983	K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3  is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel.  The KH...; Region: 30S_S3_KH; cd02412
365659005984	G-X-X-G motif; other site
365659005985	Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189
365659005986	Ribosomal protein L22/L17e.  L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit.  It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336
365659005987	putative translocon binding site; other site
365659005988	protein-rRNA interface [nucleotide binding]; other site
365659005989	30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357
365659005990	50S ribosomal protein L2; Validated; Region: rplB; PRK09374
365659005991	Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181
365659005992	Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947
365659005993	50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738
365659005994	50S ribosomal protein L4; Provisional; Region: rplD; PRK05319
365659005995	50S ribosomal protein L3; Validated; Region: rplC; PRK00001
365659005996	30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596
365659005997	Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826
365659005998	Helix-turn-helix domain; Region: HTH_38; pfam13936
365659005999	Integrase core domain; Region: rve; pfam00665
365659006000	Uridine kinase [Nucleotide transport and metabolism]; Region: Udk; COG0572
365659006001	Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190
365659006002	active site
365659006003	4Fe-4S single cluster domain; Region: Fer4_12; pfam13353
365659006004	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
365659006005	FeS/SAM binding site; other site
365659006006	Predicted acetyltransferase [General function prediction only]; Region: COG3981
365659006007	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
365659006008	anaerobic ribonucleoside triphosphate reductase; Provisional; Region: PRK09263
365659006009	ATP cone domain; Region: ATP-cone; pfam03477
365659006010	Class III ribonucleotide reductase; Region: RNR_III; cd01675
365659006011	effector binding site; other site
365659006012	active site
365659006013	Zn binding site [ion binding]; other site
365659006014	glycine loop; other site
365659006015	cardiolipin synthetase; Reviewed; Region: cls; PRK01642
365659006016	Phospholipase_D-nuclease N-terminal; Region: PLDc_N; pfam13396
365659006017	Putative catalytic domain, repeat 1, of Streptococcus mutans uncharacterized protein SMU_988 and similar proteins; Region: PLDc_SMU_988_like_1; cd09154
365659006018	putative active site [active]
365659006019	catalytic site [active]
365659006020	Putative catalytic domain, repeat 2, of Streptococcus mutans uncharacterized protein SMU_988 and similar proteins; Region: PLDc_SMU_988_like_2; cd09160
365659006021	putative active site [active]
365659006022	catalytic site [active]
365659006023	Bacterial lipoprotein; Region: DUF3642; pfam12182
365659006024	folylpolyglutamate synthase/dihydrofolate synthase; Region: folC; TIGR01499
365659006025	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
365659006026	hypothetical protein; Provisional; Region: PRK13678
365659006027	Holliday junction resolvase-like protein; Reviewed; Region: PRK00109
365659006028	hypothetical protein; Provisional; Region: PRK05473
365659006029	Arsenate Reductase (ArsC) family, Spx subfamily; Spx is a unique RNA polymerase (RNAP)-binding protein present in bacilli and some mollicutes. It inhibits transcription by binding to the C-terminal domain of the alpha subunit of RNAP, disrupting complex...; Region: ArsC_Spx; cd03032
365659006030	ArsC family; Region: ArsC; pfam03960
365659006031	putative catalytic residues [active]
365659006032	thiol/disulfide switch; other site
365659006033	magnesium-transporting ATPase; Provisional; Region: PRK15122
365659006034	Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; pfam00690
365659006035	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
365659006036	Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246
365659006037	Soluble P-type ATPase [General function prediction only]; Region: COG4087
365659006038	Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689
365659006039	Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006
365659006040	Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321
365659006041	Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092
365659006042	active site
365659006043	excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349
365659006044	ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270
365659006045	ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270
365659006046	ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271
365659006047	Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598
365659006048	uncharacterized bacterial subfamily of the Escherichia coli CorA-Salmonella typhimurium ZntB family; Region: EcCorA_ZntB-like_u2; cd12827
365659006049	Cl binding site [ion binding]; other site
365659006050	oligomer interface [polypeptide binding]; other site
365659006051	Protein of unknown function (DUF1129); Region: DUF1129; cl11555
365659006052	Microcin C7 self-immunity protein determines resistance to exogenous microcin C7; Region: Peptidase_S66_mccF_like; cd07062
365659006053	putative dimer interface [polypeptide binding]; other site
365659006054	catalytic triad [active]
365659006055	Methyladenine glycosylase; Region: Adenine_glyco; pfam03352
365659006056	Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116
365659006057	RuvA N terminal domain; Region: RuvA_N; pfam01330
365659006058	DNA mismatch repair protein; Reviewed; Region: mutL; PRK00095
365659006059	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
365659006060	ATP binding site [chemical binding]; other site
365659006061	Mg2+ binding site [ion binding]; other site
365659006062	G-X-G motif; other site
365659006063	MutL_Trans: transducer domain, having a ribosomal S5 domain 2-like fold, conserved in the C-terminal domain of DNA mismatch repair (MutL/MLH1/PMS2) family. This transducer domain is homologous to the second domain of the DNA gyrase B subunit, which is...; Region: MutL_Trans; cd00782
365659006064	ATP binding site [chemical binding]; other site
365659006065	MutL C terminal dimerisation domain; Region: MutL_C; pfam08676
365659006066	Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279
365659006067	LytTr DNA-binding domain; Region: LytTR; smart00850
365659006068	Protein of unknown function (DUF3021); Region: DUF3021; pfam11457
365659006069	flavoprotein NrdI; Provisional; Region: PRK02551
365659006070	Response regulator containing CheY-like receiver domain and AraC-type DNA-binding domain [Signal transduction mechanisms]; Region: COG4753
365659006071	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
365659006072	active site
365659006073	phosphorylation site [posttranslational modification]
365659006074	intermolecular recognition site; other site
365659006075	dimerization interface [polypeptide binding]; other site
365659006076	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
365659006077	Predicted signal transduction protein with a C-terminal ATPase domain [Signal transduction mechanisms]; Region: COG2972
365659006078	HAMP domain; Region: HAMP; pfam00672
365659006079	Histidine kinase; Region: His_kinase; pfam06580
365659006080	Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518
365659006081	ATP binding site [chemical binding]; other site
365659006082	Mg2+ binding site [ion binding]; other site
365659006083	G-X-G motif; other site
365659006084	Protein of unknown function, DUF624; Region: DUF624; cl02369
365659006085	Hypothetical bacterial integral membrane protein (Trep_Strep); Region: Trep_Strep; pfam09605
365659006086	ABC-type metal ion transport system, permease component [Inorganic ion transport and metabolism]; Region: AbcD; COG2011
365659006087	ABC-type metal ion transport system, ATPase component [Inorganic ion transport and metabolism]; Region: AbcC; COG1135
365659006088	ATP-binding cassette domain of methionine transporter; Region: ABC_MetN_methionine_transporter; cd03258
365659006089	Walker A/P-loop; other site
365659006090	ATP binding site [chemical binding]; other site
365659006091	Q-loop/lid; other site
365659006092	ABC transporter signature motif; other site
365659006093	Walker B; other site
365659006094	D-loop; other site
365659006095	H-loop/switch region; other site
365659006096	NIL domain; Region: NIL; pfam09383
365659006097	hypothetical protein; Provisional; Region: PRK06446
365659006098	Uncharacterized M20 Dipeptidases; Region: M20_dipept_like_4; cd05681
365659006099	metal binding site [ion binding]; metal-binding site
365659006100	dimer interface [polypeptide binding]; other site
365659006101	ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464
365659006102	NLPA lipoprotein; Region: Lipoprotein_9; pfam03180
365659006103	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
365659006104	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
365659006105	substrate binding pocket [chemical binding]; other site
365659006106	membrane-bound complex binding site; other site
365659006107	hinge residues; other site
365659006108	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
365659006109	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
365659006110	substrate binding pocket [chemical binding]; other site
365659006111	membrane-bound complex binding site; other site
365659006112	hinge residues; other site
365659006113	Branched-chain amino acid transport protein (AzlD); Region: AzlD; cl00735
365659006114	Predicted branched-chain amino acid permease (azaleucine resistance) [Amino acid transport and metabolism]; Region: AzlC; COG1296
365659006115	CAAX protease self-immunity; Region: Abi; pfam02517
365659006116	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
365659006117	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
365659006118	non-specific DNA binding site [nucleotide binding]; other site
365659006119	salt bridge; other site
365659006120	sequence-specific DNA binding site [nucleotide binding]; other site
365659006121	transcriptional activator, Rgg/GadR/MutR family, C-terminal domain; Region: RGG_Cterm; TIGR01716
365659006122	UGMP family protein; Validated; Region: PRK09604
365659006123	tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725
365659006124	Carbamoyltransferase; Region: CmcH_NodU; pfam02543
365659006125	ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575
365659006126	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
365659006127	Coenzyme A binding pocket [chemical binding]; other site
365659006128	Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214
365659006129	Glycoprotease family; Region: Peptidase_M22; pfam00814
365659006130	Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826
365659006131	Helix-turn-helix domain; Region: HTH_38; pfam13936
365659006132	Integrase core domain; Region: rve; pfam00665
365659006133	hypothetical protein; Provisional; Region: PRK13667
365659006134	mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595
365659006135	Metallo-beta-lactamase superfamily; Region: Lactamase_B; pfam00753
365659006136	RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521
365659006137	tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA; Validated; Region: PRK05192
365659006138	tRNA:m(5)U-54 methyltransferase; Region: gid_trmFO; TIGR00137
365659006139	GidA associated domain 3; Region: GIDA_assoc_3; pfam13932
365659006140	Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447
365659006141	nudix motif; other site
365659006142	Predicted tRNA(5-methylaminomethyl-2-thiouridylate) methyltransferase, contains the PP-loop ATPase domain [Translation, ribosomal structure and biogenesis]; Region: TrmU; COG0482
365659006143	tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998
365659006144	Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826
365659006145	Helix-turn-helix domain; Region: HTH_38; pfam13936
365659006146	Integrase core domain; Region: rve; pfam00665
365659006147	argininosuccinate lyase; Provisional; Region: PRK00855
365659006148	Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359
365659006149	active sites [active]
365659006150	tetramer interface [polypeptide binding]; other site
365659006151	argininosuccinate synthase; Provisional; Region: PRK13820
365659006152	Argininosuccinate synthase. The Argininosuccinate synthase is a urea cycle enzyme that catalyzes the penultimate step in arginine biosynthesis: the ATP-dependent ligation of citrulline to aspartate to form argininosuccinate, AMP and pyrophosphate .  In...; Region: Argininosuccinate_Synthase; cd01999
365659006153	ANP binding site [chemical binding]; other site
365659006154	Substrate Binding Site II [chemical binding]; other site
365659006155	Substrate Binding Site I [chemical binding]; other site
365659006156	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
365659006157	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
365659006158	substrate binding pocket [chemical binding]; other site
365659006159	membrane-bound complex binding site; other site
365659006160	hinge residues; other site
365659006161	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
365659006162	putative bacteriocin export ABC transporter, lactococcin 972 group; Region: L_ocin_972_ABC; TIGR03608
365659006163	Walker A/P-loop; other site
365659006164	ATP binding site [chemical binding]; other site
365659006165	Q-loop/lid; other site
365659006166	ABC transporter signature motif; other site
365659006167	Walker B; other site
365659006168	D-loop; other site
365659006169	H-loop/switch region; other site
365659006170	bacteriocin-associated integral membrane (putative immunity) protein; Region: bact_immun_7tm; TIGR01654
365659006171	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
365659006172	gallidermin-class lantibiotic protection ABC transporter, ATP-binding subunit; Region: galliderm_ABC; TIGR03740
365659006173	Walker A/P-loop; other site
365659006174	ATP binding site [chemical binding]; other site
365659006175	Q-loop/lid; other site
365659006176	ABC transporter signature motif; other site
365659006177	Walker B; other site
365659006178	D-loop; other site
365659006179	H-loop/switch region; other site
365659006180	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
365659006181	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
365659006182	non-specific DNA binding site [nucleotide binding]; other site
365659006183	salt bridge; other site
365659006184	sequence-specific DNA binding site [nucleotide binding]; other site
365659006185	FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388
365659006186	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
365659006187	L-serine dehydratase, iron-sulfur-dependent, beta subunit; Region: sda_beta; TIGR00719
365659006188	Serine dehydratase beta chain; Region: SDH_beta; pfam03315
365659006189	C-terminal ACT domain of the L-serine dehydratase (LSD), iron-sulfur-dependent, beta subunit; Region: ACT_LSD; cd04903
365659006190	putative L-serine binding site [chemical binding]; other site
365659006191	Serine dehydratase alpha chain; Region: SDH_alpha; cl12120
365659006192	L-serine deaminase [Amino acid transport and metabolism]; Region: SdaA; COG1760
365659006193	Predicted phosphatases [General function prediction only]; Region: Gph; COG0546
365659006194	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
365659006195	active site
365659006196	motif I; other site
365659006197	motif II; other site
365659006198	Predicted nucleoside-diphosphate sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG1086
365659006199	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
365659006200	UDP-Glcnac (UDP-linked N-acetylglucosamine) inverting 4,6-dehydratase, extended (e) SDRs; Region: UDP_invert_4-6DH_SDR_e; cd05237
365659006201	NAD(P) binding site [chemical binding]; other site
365659006202	homodimer interface [polypeptide binding]; other site
365659006203	substrate binding site [chemical binding]; other site
365659006204	active site
365659006205	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
365659006206	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
365659006207	active site
365659006208	Cyanate permease [Inorganic ion transport and metabolism]; Region: CynX; COG2807
365659006209	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
365659006210	Predicted transcriptional regulators [Transcription]; Region: COG1695
365659006211	Transcriptional regulator PadR-like family; Region: PadR; pfam03551
365659006212	Predicted membrane protein [Function unknown]; Region: COG4709
365659006213	Domain of unknown function (DUF4097); Region: DUF4097; pfam13349
365659006214	Domain of unknown function (DUF4299); Region: DUF4299; pfam14132
365659006215	putative rhodanese-related sulfurtransferase; Provisional; Region: PRK00142
365659006216	Member of the Rhodanese Homology Domain superfamily. This CD includes Escherichia coli YceA, Bacillus subtilis YbfQ, and similar uncharacterized proteins; Region: RHOD_YceA; cd01518
365659006217	active site residue [active]
365659006218	Protein of unknown function (DUF3650); Region: DUF3650; pfam12368
365659006219	Enterocin A Immunity; Region: EntA_Immun; pfam08951
365659006220	CAAX protease self-immunity; Region: Abi; pfam02517
365659006221	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
365659006222	Domain of unknown function (DUF3502); Region: DUF3502; pfam12010
365659006223	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
365659006224	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
365659006225	dimer interface [polypeptide binding]; other site
365659006226	conserved gate region; other site
365659006227	putative PBP binding loops; other site
365659006228	ABC-ATPase subunit interface; other site
365659006229	ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209
365659006230	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
365659006231	dimer interface [polypeptide binding]; other site
365659006232	conserved gate region; other site
365659006233	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427
365659006234	ABC-ATPase subunit interface; other site
365659006235	Glycosyl hydrolase family 20 (GH20) catalytic domain of N-acetyl-beta-D-glucosaminidase (GcnA, also known as BhsA) and related proteins. GcnA  is an exoglucosidase which cleaves N-acetyl-beta-D-galactosamine (NAG) and N-acetyl-beta-D-galactosamine...; Region: GH20_GcnA-like; cd06565
365659006236	putative active site [active]
365659006237	Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940
365659006238	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012
365659006239	nucleotide binding site [chemical binding]; other site
365659006240	Alpha-mannosidase [Carbohydrate transport and metabolism]; Region: AMS1; COG0383
365659006241	N-terminal catalytic domain of SPGH38, a putative alpha-mannosidase of Streptococcus pyogenes, and its prokaryotic homologs; glycoside hydrolase family 38 (GH38); Region: GH38N_AMII_SpGH38_like; cd10814
365659006242	active site
365659006243	metal binding site [ion binding]; metal-binding site
365659006244	homodimer interface [polypeptide binding]; other site
365659006245	catalytic site [active]
365659006246	Alpha mannosidase, middle domain; Region: Alpha-mann_mid; smart00872
365659006247	Uncharacterized conserved protein [Function unknown]; Region: COG3538
365659006248	Protein of unknown function (DUF1237); Region: DUF1237; pfam06824
365659006249	phage transcriptional regulator, ArpU family; Region: phage_arpU; TIGR01637
365659006250	PIN (PilT N terminus) domain: Superfamily; Region: PIN_SF; cl14812
365659006251	putative active site [active]
365659006252	Phage associated DNA primase [General function prediction only]; Region: COG3378
365659006253	D5 N terminal like; Region: D5_N; smart00885
365659006254	Poxvirus D5 protein-like; Region: Pox_D5; pfam03288
365659006255	Primase C terminal 1 (PriCT-1); Region: PriCT_1; pfam08708
365659006256	Uncharacterized phage-encoded protein [Function unknown]; Region: COG3646
365659006257	Phage regulatory protein Rha (Phage_pRha); Region: Phage_pRha; pfam09669
365659006258	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl17200
365659006259	non-specific DNA binding site [nucleotide binding]; other site
365659006260	salt bridge; other site
365659006261	sequence-specific DNA binding site [nucleotide binding]; other site
365659006262	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
365659006263	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
365659006264	non-specific DNA binding site [nucleotide binding]; other site
365659006265	salt bridge; other site
365659006266	sequence-specific DNA binding site [nucleotide binding]; other site
365659006267	Predicted transcriptional regulator containing an HTH domain and an uncharacterized domain shared with the mammalian protein Schlafen [Transcription]; Region: COG2865
365659006268	Divergent AAA domain; Region: AAA_4; pfam04326
365659006269	ATP-dependent DNA helicase recG C-terminal; Region: HATPase_c_4; pfam13749
365659006270	Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582
365659006271	phiLC3 phage and phage-related integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes various bacterial (mainly gram positive) and phage integrases, including those similar to Lactococcus...; Region: INT_phiLC3_C; cd01189
365659006272	Int/Topo IB signature motif; other site
365659006273	Putative alpha-1,2-mannosidase [Carbohydrate transport and metabolism]; Region: COG3537
365659006274	Glycosyl hydrolase family 92; Region: Glyco_hydro_92; pfam07971
365659006275	Alpha-L-fucosidase [Carbohydrate transport and metabolism]; Region: COG3669
365659006276	Alpha-L-fucosidase; Region: Alpha_L_fucos; cl12119
365659006277	F5/8 type C domain; Region: F5_F8_type_C; pfam00754
365659006278	Bacterial Ig-like domain (group 4); Region: Big_4; pfam07532
365659006279	Bacterial Ig-like domain (group 4); Region: Big_4; pfam07532
365659006280	Beta-galactosidase/beta-glucuronidase [Carbohydrate transport and metabolism]; Region: LacZ; COG3250
365659006281	Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837
365659006282	Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703
365659006283	Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836
365659006284	Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330
365659006285	A subgroup of the band 7 domain of flotillin (reggie) like proteins. This subgroup contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin.  Many of these band 7 domain-containing proteins are lipid raft-associated.  Individual...; Region: Band_7_4; cd03407
365659006286	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
365659006287	active site
365659006288	motif I; other site
365659006289	motif II; other site
365659006290	ABC-type metal ion transport system, periplasmic component/surface adhesin [Inorganic ion transport and metabolism]; Region: LraI; COG0803
365659006291	Metal binding protein AcdA.  These proteins have been shown to function in the ABC uptake of Zn2+ and Mn2+ and in competence for genetic transformation and adhesion. The AcdA proteins belong to the TroA superfamily of helical backbone metal receptor...; Region: AdcA; cd01017
365659006292	metal binding site [ion binding]; metal-binding site
365659006293	YodA lipocalin-like domain; Region: YodA; pfam09223
365659006294	ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108
365659006295	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
365659006296	ABC-ATPase subunit  interface; other site
365659006297	dimer interface [polypeptide binding]; other site
365659006298	putative PBP binding regions; other site
365659006299	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
365659006300	ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235
365659006301	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
365659006302	putative DNA binding site [nucleotide binding]; other site
365659006303	Protein involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein) [Cell envelope biogenesis, outer membrane]; Region: DltD; COG3966
365659006304	DltD N-terminal region; Region: DltD_N; pfam04915
365659006305	DltD central region; Region: DltD_M; pfam04918
365659006306	DltD C-terminal region; Region: DltD_C; pfam04914
365659006307	D-alanine--poly(phosphoribitol) ligase subunit 2; Validated; Region: PRK05087
365659006308	D-alanyl-lipoteichoic acid biosynthesis protein DltB; Region: LTA_dltB; TIGR04091
365659006309	D-alanine--poly(phosphoribitol) ligase subunit 1; Provisional; Region: PRK04813
365659006310	D-alanine:D-alanyl carrier protein ligase (DltA); Region: DltA; cd05945
365659006311	acyl-activating enzyme (AAE) consensus motif; other site
365659006312	AMP binding site [chemical binding]; other site
365659006313	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
365659006314	putative substrate translocation pore; other site
365659006315	Glycerol uptake facilitator and related permeases (Major Intrinsic Protein Family) [Carbohydrate transport and metabolism]; Region: GlpF; COG0580
365659006316	amphipathic channel; other site
365659006317	Asn-Pro-Ala signature motifs; other site
365659006318	Glycerol-3-phosphate dehydrogenase [Energy production and conversion]; Region: GlpA; COG0578
365659006319	glycerol kinase; Provisional; Region: glpK; PRK00047
365659006320	Escherichia coli glycerol kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_EcGK_like; cd07786
365659006321	N- and C-terminal domain interface [polypeptide binding]; other site
365659006322	active site
365659006323	MgATP binding site [chemical binding]; other site
365659006324	catalytic site [active]
365659006325	metal binding site [ion binding]; metal-binding site
365659006326	glycerol binding site [chemical binding]; other site
365659006327	homotetramer interface [polypeptide binding]; other site
365659006328	homodimer interface [polypeptide binding]; other site
365659006329	FBP binding site [chemical binding]; other site
365659006330	protein IIAGlc interface [polypeptide binding]; other site
365659006331	Mga helix-turn-helix domain; Region: Mga; pfam05043
365659006332	Hsp33-like chaperonin; Reviewed; Region: hslO; PRK00114
365659006333	Heat shock protein 33 (Hsp33):  Cytosolic protein that acts as a molecular chaperone under oxidative conditions.  In normal (reducing) cytosolic conditions, four conserved Cys residues are coordinated by a Zn ion. Under oxidative stress (such as heat...; Region: Hsp33; cd00498
365659006334	dimerization interface [polypeptide binding]; other site
365659006335	domain crossover interface; other site
365659006336	redox-dependent activation switch; other site
365659006337	putative TIM-barrel protein, nifR3 family; Region: nifR3_yhdG; TIGR00737
365659006338	Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801
365659006339	FMN binding site [chemical binding]; other site
365659006340	active site
365659006341	catalytic residues [active]
365659006342	substrate binding site [chemical binding]; other site
365659006343	Protein of unknown function (DUF1275); Region: DUF1275; pfam06912
365659006344	Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cd02883
365659006345	nudix motif; other site
365659006346	nicotinamide mononucleotide transporter PnuC; Region: NMN_trans_PnuC; TIGR01528
365659006347	nicotinamide-nucleotide adenylyltransferase, NadR type; Region: nadR_NMN_Atrans; TIGR01526
365659006348	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
365659006349	active site
365659006350	nucleotide binding site [chemical binding]; other site
365659006351	HIGH motif; other site
365659006352	KMSKS motif; other site
365659006353	Predicted ATPase/kinase involved in NAD metabolism [Coenzyme metabolism]; Region: NadR; COG3172
365659006354	ATP-binding subunits of Clp protease and DnaK/DnaJ chaperones [Posttranslational modification, protein turnover, chaperones]; Region: clpA; COG0542
365659006355	Clp amino terminal domain; Region: Clp_N; pfam02861
365659006356	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
365659006357	Walker A motif; other site
365659006358	ATP binding site [chemical binding]; other site
365659006359	Walker B motif; other site
365659006360	arginine finger; other site
365659006361	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
365659006362	Walker A motif; other site
365659006363	ATP binding site [chemical binding]; other site
365659006364	Walker B motif; other site
365659006365	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431
365659006366	Transcriptional repressor of class III stress genes [Transcription]; Region: CtsR; COG4463
365659006367	ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116
365659006368	ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293
365659006369	Walker A/P-loop; other site
365659006370	ATP binding site [chemical binding]; other site
365659006371	Q-loop/lid; other site
365659006372	ABC transporter signature motif; other site
365659006373	Walker B; other site
365659006374	D-loop; other site
365659006375	H-loop/switch region; other site
365659006376	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cl17432
365659006377	NMT1/THI5 like; Region: NMT1; pfam09084
365659006378	ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600
365659006379	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
365659006380	dimer interface [polypeptide binding]; other site
365659006381	conserved gate region; other site
365659006382	putative PBP binding loops; other site
365659006383	ABC-ATPase subunit interface; other site
365659006384	Uncharacterized conserved protein [Function unknown]; Region: COG0011
365659006385	Surface antigen [General function prediction only]; Region: COG3942
365659006386	CHAP domain; Region: CHAP; pfam05257
365659006387	FOG: Glucan-binding domain (YG repeat) [General function prediction only]; Region: COG5263
365659006388	Bacterial SH3 domain; Region: SH3_5; pfam08460
365659006389	Putative cell wall binding repeat; Region: CW_binding_1; pfam01473
365659006390	Protein of unknown function (DUF1021); Region: DUF1021; cl01852
365659006391	replicative DNA helicase; Provisional; Region: PRK05748
365659006392	DnaB-like helicase N terminal domain; Region: DnaB; pfam00772
365659006393	DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the  chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984
365659006394	Walker A motif; other site
365659006395	ATP binding site [chemical binding]; other site
365659006396	Walker B motif; other site
365659006397	DNA binding loops [nucleotide binding]
365659006398	50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137
365659006399	Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281
365659006400	Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948
365659006401	Predicted signaling protein consisting of a modified GGDEF domain and a DHH domain [Signal transduction mechanisms]; Region: COG3887
365659006402	DHH family; Region: DHH; pfam01368
365659006403	DHHA1 domain; Region: DHHA1; pfam02272
365659006404	RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY,  is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552
365659006405	30S subunit binding site; other site
365659006406	comF family protein; Region: comF; TIGR00201
365659006407	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
365659006408	active site
365659006409	Superfamily II DNA/RNA helicase required for DNA uptake (late competence protein) [DNA replication, recombination, and repair]; Region: comFA; COG4098
365659006410	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
365659006411	ATP binding site [chemical binding]; other site
365659006412	putative Mg++ binding site [ion binding]; other site
365659006413	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
365659006414	nucleotide binding region [chemical binding]; other site
365659006415	ATP-binding site [chemical binding]; other site
365659006416	Uncharacterized conserved protein [Function unknown]; Region: COG1739
365659006417	Uncharacterized protein family UPF0029; Region: UPF0029; pfam01205
365659006418	Domain of unknown function (DUF1949); Region: DUF1949; pfam09186
365659006419	Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031
365659006420	CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561
365659006421	dimer interface [polypeptide binding]; other site
365659006422	pyridoxal 5'-phosphate binding site [chemical binding]; other site
365659006423	catalytic residue [active]
365659006424	elongation factor Ts; Provisional; Region: tsf; PRK09377
365659006425	UBA/TS-N domain; Region: UBA; pfam00627
365659006426	Elongation factor TS; Region: EF_TS; pfam00889
365659006427	Elongation factor TS; Region: EF_TS; pfam00889
365659006428	Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425
365659006429	rRNA interaction site [nucleotide binding]; other site
365659006430	S8 interaction site; other site
365659006431	putative laminin-1 binding site; other site
365659006432	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3883
365659006433	Septum formation initiator; Region: DivIC; cl17659
365659006434	Surface antigen [General function prediction only]; Region: COG3942
365659006435	CHAP domain; Region: CHAP; pfam05257
365659006436	Cell shape-determining protein [Cell envelope biogenesis, outer membrane]; Region: MreD; COG2891
365659006437	Cell shape-determining protein [Cell envelope biogenesis, outer membrane]; Region: MreC; COG1792
365659006438	Regulator of replication initiation timing [Replication,    recombination, and repair]; Region: COG4467; cl01853
365659006439	rod shape-determining protein MreC; Region: MreC; pfam04085
365659006440	ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619
365659006441	cobalt transporter ATP-binding subunit; Provisional; Region: cbiO; PRK13649
365659006442	First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225
365659006443	Walker A/P-loop; other site
365659006444	ATP binding site [chemical binding]; other site
365659006445	Q-loop/lid; other site
365659006446	ABC transporter signature motif; other site
365659006447	Walker B; other site
365659006448	D-loop; other site
365659006449	H-loop/switch region; other site
365659006450	cobalt transporter ATP-binding subunit; Provisional; Region: cbiO; PRK13650
365659006451	First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225
365659006452	Walker A/P-loop; other site
365659006453	ATP binding site [chemical binding]; other site
365659006454	Q-loop/lid; other site
365659006455	ABC transporter signature motif; other site
365659006456	Walker B; other site
365659006457	D-loop; other site
365659006458	H-loop/switch region; other site
365659006459	CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453
365659006460	Predicted transcriptional regulator contains Xre-like HTH domain [Function unknown]; Region: COG1426
365659006461	Helix-turn-helix domain; Region: HTH_25; pfam13413
365659006462	Domain of unknown function (DUF4115); Region: DUF4115; pfam13464
365659006463	Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612
365659006464	Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675
365659006465	Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193
365659006466	Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612
365659006467	Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193
365659006468	S4-like RNA binding protein [Replication, recombination, and repair]; Region: COG2501
365659006469	Recombinational DNA repair ATPase (RecF pathway) [DNA replication, recombination, and repair]; Region: RecF; COG1195
365659006470	ATP-binding cassette domain of RecF; Region: ABC_RecF; cd03242
365659006471	Walker A/P-loop; other site
365659006472	ATP binding site [chemical binding]; other site
365659006473	Q-loop/lid; other site
365659006474	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
365659006475	ABC transporter signature motif; other site
365659006476	Walker B; other site
365659006477	D-loop; other site
365659006478	H-loop/switch region; other site
365659006479	inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567
365659006480	TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186
365659006481	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein.  IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a...; Region: CBS_pair_IMPDH; cd04601
365659006482	IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381
365659006483	active site
365659006484	tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282
365659006485	catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806
365659006486	active site
365659006487	HIGH motif; other site
365659006488	dimer interface [polypeptide binding]; other site
365659006489	KMSKS motif; other site
365659006490	ABC transporter ATP-binding protein; Provisional; Region: PRK15064
365659006491	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
365659006492	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
365659006493	ABC transporter; Region: ABC_tran_2; pfam12848
365659006494	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
365659006495	Predicted membrane protein [Function unknown]; Region: COG4485
365659006496	Predicted membrane protein [Function unknown]; Region: COG1511
365659006497	YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061
365659006498	X-X-X-Leu-X-X-Gly heptad repeats; Region: xxxLxxG_by_4; TIGR03057
365659006499	YhgE/Pip C-terminal domain; Region: pip_yhgE_Cterm; TIGR03062
365659006500	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
365659006501	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
365659006502	Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279
365659006503	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
365659006504	active site
365659006505	phosphorylation site [posttranslational modification]
365659006506	intermolecular recognition site; other site
365659006507	dimerization interface [polypeptide binding]; other site
365659006508	LytTr DNA-binding domain; Region: LytTR; pfam04397
365659006509	Predicted signal transduction protein with a C-terminal ATPase domain [Signal transduction mechanisms]; Region: COG2972
365659006510	Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518
365659006511	COMC family; Region: ComC; pfam03047
365659006512	rRNA large subunit methyltransferase; Provisional; Region: PRK00103
365659006513	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265
365659006514	Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365
365659006515	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
365659006516	protein binding site [polypeptide binding]; other site
365659006517	ParB/RepB/Spo0J family partition protein; Region: parB_part; TIGR00180
365659006518	ParB-like nuclease domain; Region: ParBc; pfam02195
365659006519	KorB domain; Region: KorB; pfam08535