-- dump date 20140620_083019 -- class Genbank::misc_feature -- table misc_feature_note -- id note 1198676000001 chromosomal replication initiation protein; Reviewed; Region: dnaA; PRK00149 1198676000002 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1198676000003 Walker A motif; other site 1198676000004 ATP binding site [chemical binding]; other site 1198676000005 Walker B motif; other site 1198676000006 arginine finger; other site 1198676000007 C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571 1198676000008 DnaA box-binding interface [nucleotide binding]; other site 1198676000009 DNA polymerase III subunit beta; Validated; Region: PRK05643 1198676000010 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140 1198676000011 putative DNA binding surface [nucleotide binding]; other site 1198676000012 dimer interface [polypeptide binding]; other site 1198676000013 beta-clamp/clamp loader binding surface; other site 1198676000014 beta-clamp/translesion DNA polymerase binding surface; other site 1198676000015 Bacterial protein of unknown function (DUF951); Region: DUF951; pfam06107 1198676000016 GTP-binding protein YchF; Reviewed; Region: PRK09601 1198676000017 YchF GTPase; Region: YchF; cd01900 1198676000018 G1 box; other site 1198676000019 GTP/Mg2+ binding site [chemical binding]; other site 1198676000020 Switch I region; other site 1198676000021 G2 box; other site 1198676000022 Switch II region; other site 1198676000023 G3 box; other site 1198676000024 G4 box; other site 1198676000025 G5 box; other site 1198676000026 TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867 1198676000027 Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462 1198676000028 putative active site [active] 1198676000029 catalytic residue [active] 1198676000030 Transcription-repair coupling factor (superfamily II helicase) [DNA replication, recombination, and repair / Transcription]; Region: Mfd; COG1197 1198676000031 CarD-like/TRCF domain; Region: CarD_TRCF; smart01058 1198676000032 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1198676000033 ATP binding site [chemical binding]; other site 1198676000034 putative Mg++ binding site [ion binding]; other site 1198676000035 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1198676000036 nucleotide binding region [chemical binding]; other site 1198676000037 ATP-binding site [chemical binding]; other site 1198676000038 This domain is found in proteins necessary for strand-specific repair in DNA such as TRCF in Escherichia coli; Region: TRCF; smart00982 1198676000039 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1198676000040 RNA binding surface [nucleotide binding]; other site 1198676000041 Septum formation initiator [Cell division and chromosome partitioning]; Region: COG2919 1198676000042 Septum formation initiator; Region: DivIC; pfam04977 1198676000043 Beta-lactamase enzyme family; Region: Beta-lactamase2; pfam13354 1198676000044 tRNA(Ile)-lysidine synthase MesJ [Cell cycle control, cell division, chromosome partitioning]; Region: MesJ; COG0037 1198676000045 N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992 1198676000046 Ligand Binding Site [chemical binding]; other site 1198676000047 TilS substrate C-terminal domain; Region: TilS_C; smart00977 1198676000048 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1198676000049 active site 1198676000050 ATP-dependent Zn proteases [Posttranslational modification, protein turnover, chaperones]; Region: HflB; COG0465 1198676000051 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1198676000052 Walker A motif; other site 1198676000053 ATP binding site [chemical binding]; other site 1198676000054 Walker B motif; other site 1198676000055 arginine finger; other site 1198676000056 Peptidase family M41; Region: Peptidase_M41; pfam01434 1198676000057 amino acid transporter; Region: 2A0306; TIGR00909 1198676000058 C-terminus of AA_permease; Region: AA_permease_C; pfam13906 1198676000059 potential protein location (hypothetical protein SMUGS5_00075 [Streptococcus mutans GS-5]) that overlaps RNA (tRNA-M) 1198676000060 rod shape-determining protein MreC; Provisional; Region: PRK13922 1198676000061 rod shape-determining protein MreC; Region: MreC; pfam04085 1198676000062 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3883 1198676000063 Surface antigen [General function prediction only]; Region: COG3942 1198676000064 CHAP domain; Region: CHAP; pfam05257 1198676000065 ribose-phosphate pyrophosphokinase; Provisional; Region: PRK02269 1198676000066 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 1198676000067 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1198676000068 active site 1198676000069 aromatic amino acid aminotransferase; Validated; Region: PRK07309 1198676000070 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1198676000071 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1198676000072 homodimer interface [polypeptide binding]; other site 1198676000073 catalytic residue [active] 1198676000074 Recombination protein O N terminal; Region: RecO_N; pfam11967 1198676000075 DNA repair protein RecO; Region: reco; TIGR00613 1198676000076 Recombination protein O C terminal; Region: RecO_C; pfam02565 1198676000077 putative phosphate acyltransferase; Provisional; Region: PRK05331 1198676000078 acyl carrier protein; Provisional; Region: PRK12449 1198676000079 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1198676000080 Walker A/P-loop; other site 1198676000081 ATP binding site [chemical binding]; other site 1198676000082 ABC transporter; Region: ABC_tran; pfam00005 1198676000083 Q-loop/lid; other site 1198676000084 ABC transporter signature motif; other site 1198676000085 Walker B; other site 1198676000086 D-loop; other site 1198676000087 H-loop/switch region; other site 1198676000088 phosphoribosylaminoimidazole-succinocarboxamide synthase; Reviewed; Region: PRK09362 1198676000089 bacterial and archaeal 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_PurC; cd01415 1198676000090 ATP binding site [chemical binding]; other site 1198676000091 active site 1198676000092 substrate binding site [chemical binding]; other site 1198676000093 phosphoribosylformylglycinamidine synthase, clade II; Region: FGAM-synthase; TIGR01857 1198676000094 AIR (aminoimidazole ribonucleotide) synthase related protein. This family includes Hydrogen expression/formation protein HypE, AIR synthases, FGAM (formylglycinamidine ribonucleotide) synthase and Selenophosphate synthetase (SelD). The N-terminal domain...; Region: PurM-like; cl10019 1198676000095 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203 1198676000096 dimerization interface [polypeptide binding]; other site 1198676000097 ATP binding site [chemical binding]; other site 1198676000098 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat2; cd02204 1198676000099 dimerization interface [polypeptide binding]; other site 1198676000100 ATP binding site [chemical binding]; other site 1198676000101 Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740 1198676000102 putative active site [active] 1198676000103 catalytic triad [active] 1198676000104 amidophosphoribosyltransferase; Provisional; Region: PRK07272 1198676000105 Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715 1198676000106 active site 1198676000107 tetramer interface [polypeptide binding]; other site 1198676000108 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1198676000109 active site 1198676000110 phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385 1198676000111 PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196 1198676000112 dimerization interface [polypeptide binding]; other site 1198676000113 putative ATP binding site [chemical binding]; other site 1198676000114 phosphoribosylglycinamide formyltransferase; Reviewed; Region: purN; PRK05647 1198676000115 Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645 1198676000116 active site 1198676000117 substrate binding site [chemical binding]; other site 1198676000118 cosubstrate binding site; other site 1198676000119 catalytic site [active] 1198676000120 Suppressor of fused protein (SUFU); Region: SUFU; pfam05076 1198676000121 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881 1198676000122 Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal ATIC formylase domain that formylates...; Region: IMPCH; cd01421 1198676000123 purine monophosphate binding site [chemical binding]; other site 1198676000124 dimer interface [polypeptide binding]; other site 1198676000125 putative catalytic residues [active] 1198676000126 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; smart00798 1198676000127 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; cl03362 1198676000128 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1198676000129 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1198676000130 Protein of unknown function with HXXEE motif; Region: HXXEE; pfam13787 1198676000131 Cytotoxic translational repressor of toxin-antitoxin stability system [Translation, ribosomal structure and biogenesis / Cell division and chromosome partitioning]; Region: RelE; COG2026 1198676000132 Abi-like protein; Region: Abi_2; pfam07751 1198676000133 AAA domain; Region: AAA_21; pfam13304 1198676000134 Site-specific DNA methylase [DNA replication, recombination, and repair]; Region: Dam; COG0338 1198676000135 phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885 1198676000136 Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844 1198676000137 Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Region: GARS_A; pfam01071 1198676000138 Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843 1198676000139 ATP-grasp domain; Region: ATP-grasp_4; pfam13535 1198676000140 Phosphoribosylcarboxyaminoimidazole (NCAIR) mutase [Nucleotide transport and metabolism]; Region: PurE; COG0041 1198676000141 phosphoribosylaminoimidazole carboxylase ATPase subunit; Reviewed; Region: PRK06019 1198676000142 ATP-grasp domain; Region: ATP-grasp; pfam02222 1198676000143 Aspartate racemase [Cell envelope biogenesis, outer membrane]; Region: RacX; COG1794 1198676000144 aspartate racemase; Region: asp_race; TIGR00035 1198676000145 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 1198676000146 hydrophobic ligand binding site; other site 1198676000147 adenylosuccinate lyase; Provisional; Region: PRK07492 1198676000148 Adenylsuccinate lyase (ASL)_subgroup 1; Region: Adenylsuccinate_lyase_1; cd01360 1198676000149 tetramer interface [polypeptide binding]; other site 1198676000150 active site 1198676000151 DNA alkylation repair enzyme; Region: DNA_alkylation; pfam08713 1198676000152 A new structural DNA glycosylase; Region: AlkD_like; cl11434 1198676000153 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1198676000154 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1198676000155 non-specific DNA binding site [nucleotide binding]; other site 1198676000156 salt bridge; other site 1198676000157 sequence-specific DNA binding site [nucleotide binding]; other site 1198676000158 Domain of unknown function (DUF4353); Region: DUF4353; pfam14262 1198676000159 Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080 1198676000160 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1198676000161 Walker A motif; other site 1198676000162 ATP binding site [chemical binding]; other site 1198676000163 Walker B motif; other site 1198676000164 arginine finger; other site 1198676000165 Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491 1198676000166 Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394 1198676000167 Low molecular weight phosphatase family; Region: LMWPc; cd00115 1198676000168 active site 1198676000169 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4642 1198676000170 Acyltransferase family; Region: Acyl_transf_3; pfam01757 1198676000171 glucans biosynthesis protein; Provisional; Region: opgC; PRK03854 1198676000172 yrhL-like subfamily of SGNH-hydrolases, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase_yrhL_like; cd01840 1198676000173 catalytic triad [active] 1198676000174 catalytic triad [active] 1198676000175 oxyanion hole [active] 1198676000176 Threonine synthase catalyzes the final step of threonine biosynthesis. The conversion of O-phosphohomoserine into threonine and inorganic phosphate is pyridoxal 5'-phosphate dependent. The Thr-synth_1 CD includes members from higher plants; Region: Thr-synth_2; cd01560 1198676000177 Threonine synthase [Amino acid transport and metabolism]; Region: ThrC; COG0498 1198676000178 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1198676000179 catalytic residue [active] 1198676000180 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 1198676000181 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Thermotoga marina NorM; Region: MATE_NorM_like; cd13137 1198676000182 ACT domain proteins similar to the yet uncharacterized Streptococcus pneumoniae ACT domain protein; Region: ACT_1ZPV; cd04872 1198676000183 Uncharacterized proteins with similarity to Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL_like_DUF711; cd08025 1198676000184 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1198676000185 catalytic core [active] 1198676000186 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1198676000187 D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: VanY; COG1876 1198676000188 D-alanyl-D-alanine carboxypeptidase; Region: VanY; pfam02557 1198676000189 Muramidase (flagellum-specific) [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FlgJ; COG1705 1198676000190 KxYKxGKxW signal peptide; Region: KxYKxGKxW; TIGR03715 1198676000191 Domain of Unknown Function (DUF1080); Region: DUF1080; pfam06439 1198676000192 Cadherin-like beta sandwich domain; Region: Cadherin-like; pfam12733 1198676000193 Glycosyl hydrolases family 32; Region: Glyco_32; smart00640 1198676000194 Glycosyl hydrolase family 32, beta-fructosidases; Region: GH32_B_Fructosidase; cd08996 1198676000195 substrate binding [chemical binding]; other site 1198676000196 active site 1198676000197 Glycosyl hydrolases family 32 C terminal; Region: Glyco_hydro_32C; pfam08244 1198676000198 Bacterial Ig-like domain (group 2); Region: Big_2; pfam02368 1198676000199 Laminin G domain; Region: Laminin_G_2; pfam02210 1198676000200 Glycosyl hydrolases family 32; Region: Glyco_32; smart00640 1198676000201 Glycosyl hydrolase family 32, beta-fructosidases; Region: GH32_B_Fructosidase; cd08996 1198676000202 substrate binding [chemical binding]; other site 1198676000203 active site 1198676000204 heat-inducible transcription repressor; Provisional; Region: hrcA; PRK00082 1198676000205 Winged helix-turn-helix transcription repressor, HrcA DNA-binding; Region: HrcA_DNA-bdg; pfam03444 1198676000206 GrpE; Region: GrpE; pfam01025 1198676000207 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446 1198676000208 dimer interface [polypeptide binding]; other site 1198676000209 hsp70 (ATPase domain) interactions [polypeptide binding]; other site 1198676000210 molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290 1198676000211 Nucleotide-binding domain of human HSPA9 and similar proteins; Region: HSPA9-Ssq1-like_NBD; cd10234 1198676000212 nucleotide binding site [chemical binding]; other site 1198676000213 NEF interaction site [polypeptide binding]; other site 1198676000214 SBD interface [polypeptide binding]; other site 1198676000215 chaperone protein DnaJ; Provisional; Region: PRK14276 1198676000216 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 1198676000217 HSP70 interaction site [polypeptide binding]; other site 1198676000218 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cl03262 1198676000219 substrate binding site [polypeptide binding]; other site 1198676000220 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 1198676000221 Zn binding sites [ion binding]; other site 1198676000222 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 1198676000223 dimer interface [polypeptide binding]; other site 1198676000224 tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021 1198676000225 Eukaryotic and bacterial pseudouridine synthases similar to E. coli TruA; Region: PseudoU_synth_EcTruA; cd02570 1198676000226 dimerization interface 3.5A [polypeptide binding]; other site 1198676000227 active site 1198676000228 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 1198676000229 dimer interface [polypeptide binding]; other site 1198676000230 substrate binding site [chemical binding]; other site 1198676000231 ATP binding site [chemical binding]; other site 1198676000232 ECF-type riboflavin transporter, S component; Region: ECF-ribofla_trS; pfam07155 1198676000233 hypothetical protein; Provisional; Region: PRK13690 1198676000234 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 1198676000235 Mechanosensitive ion channel; Region: MS_channel; pfam00924 1198676000236 Formate/nitrite transporter; Region: Form_Nir_trans; cl00927 1198676000237 trigger factor; Provisional; Region: tig; PRK01490 1198676000238 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 1198676000239 Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698 1198676000240 DNA-directed RNA polymerase delta subunit; Region: RNA_pol_delta; pfam05066 1198676000241 CTP synthetase; Validated; Region: pyrG; PRK05380 1198676000242 CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113 1198676000243 Catalytic site [active] 1198676000244 active site 1198676000245 UTP binding site [chemical binding]; other site 1198676000246 Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746 1198676000247 active site 1198676000248 putative oxyanion hole; other site 1198676000249 catalytic triad [active] 1198676000250 fructose-bisphosphate aldolase; Provisional; Region: PRK09197 1198676000251 Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947 1198676000252 intersubunit interface [polypeptide binding]; other site 1198676000253 active site 1198676000254 zinc binding site [ion binding]; other site 1198676000255 Na+ binding site [ion binding]; other site 1198676000256 PTS system sorbose subfamily IIB component; Region: PTSIIB_sorb; pfam03830 1198676000257 active site 1198676000258 phosphorylation site [posttranslational modification] 1198676000259 PTS system sorbose-specific iic component; Region: EII-Sor; pfam03609 1198676000260 PTS system mannose/fructose/sorbose family IID component; Region: EIID-AGA; pfam03613 1198676000261 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cl00025 1198676000262 active pocket/dimerization site; other site 1198676000263 active site 1198676000264 phosphorylation site [posttranslational modification] 1198676000265 Alpha-glucosidases, family 31 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: COG1501 1198676000266 This family represents an uncharacterized glycosyl hydrolase family 31 (GH31) enzyme found in bacteria and eukaryotes that is related to the XylS xylosidase of Sulfolobus solfataricus. Alpha-xylosidases catalyze the release of an alpha-xylose residue...; Region: GH31_xylosidase_XylS-like; cd06595 1198676000267 putative active site [active] 1198676000268 putative catalytic site [active] 1198676000269 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1198676000270 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1198676000271 DNA binding site [nucleotide binding] 1198676000272 domain linker motif; other site 1198676000273 Ligand binding domain of the lacI-like transcription regulator from a novel metal-reducing bacterium Alkaliphilus Metalliredigens (strain Qymf) and its close homologs; Region: PBP1_Qymf_like; cd06291 1198676000274 dimerization interface [polypeptide binding]; other site 1198676000275 ligand binding site [chemical binding]; other site 1198676000276 sodium binding site [ion binding]; other site 1198676000277 Transposase DDE domain; Region: DDE_Tnp_1_3; pfam13612 1198676000278 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1198676000279 S-adenosylmethionine binding site [chemical binding]; other site 1198676000280 potential frameshift: common BLAST hit: gi|24378630|ref|NP_720585.1| permease 1198676000281 Helix-turn-helix domain; Region: HTH_19; pfam12844 1198676000282 sequence-specific DNA binding site [nucleotide binding]; other site 1198676000283 salt bridge; other site 1198676000284 transcriptional activator, Rgg/GadR/MutR family, C-terminal domain; Region: RGG_Cterm; TIGR01716 1198676000285 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 1198676000286 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 1198676000287 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 1198676000288 putative active site [active] 1198676000289 Fructose-1-phosphate kinase and related fructose-6-phosphate kinase (PfkB) [Carbohydrate transport and metabolism]; Region: FruK; COG1105 1198676000290 1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164 1198676000291 putative substrate binding site [chemical binding]; other site 1198676000292 putative ATP binding site [chemical binding]; other site 1198676000293 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569 1198676000294 active site 1198676000295 P-loop; other site 1198676000296 phosphorylation site [posttranslational modification] 1198676000297 Phosphotransferase system, fructose-specific IIC component [Carbohydrate transport and metabolism]; Region: FruA; COG1299 1198676000298 Phosphotransferase system, EIIC; Region: PTS_EIIC; pfam02378 1198676000299 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 1198676000300 active site 1198676000301 phosphorylation site [posttranslational modification] 1198676000302 tagatose 1,6-diphosphate aldolase; Reviewed; Region: PRK04161 1198676000303 S-formylglutathione hydrolase; Region: PLN02442 1198676000304 S-formylglutathione hydrolase; Region: fghA_ester_D; TIGR02821 1198676000305 class III alcohol dehydrogenases; Region: alcohol_DH_class_III; cd08300 1198676000306 S-(hydroxymethyl)glutathione dehydrogenase/class III alcohol dehydrogenase; Region: adh_III_F_hyde; TIGR02818 1198676000307 substrate binding site [chemical binding]; other site 1198676000308 catalytic Zn binding site [ion binding]; other site 1198676000309 NAD binding site [chemical binding]; other site 1198676000310 structural Zn binding site [ion binding]; other site 1198676000311 dimer interface [polypeptide binding]; other site 1198676000312 50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359 1198676000313 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 1198676000314 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Bacillus subtilis yoeA; Region: MATE_yoeA_like; cd13138 1198676000315 DNA polymerase III PolC; Validated; Region: polC; PRK00448 1198676000316 DNA polymerase III polC-type N-terminus; Region: DNA_pol3_alph_N; pfam11490 1198676000317 polC_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold nucleic acid binding domain of Bacillus subtilis type C replicative DNA polymerase III alpha subunit (polC). Replication in B. subtilis and Staphylococcus aureus requires two...; Region: polC_OBF; cd04484 1198676000318 generic binding surface II; other site 1198676000319 generic binding surface I; other site 1198676000320 Polymerase and Histidinol Phosphatase domain; Region: PHP; cl17102 1198676000321 active site 1198676000322 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 1198676000323 active site 1198676000324 catalytic site [active] 1198676000325 substrate binding site [chemical binding]; other site 1198676000326 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III at PolC gene; Region: PHP_PolIIIA_POLC; cd07435 1198676000327 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1198676000328 MarR family; Region: MarR; pfam01047 1198676000329 Predicted flavoprotein [General function prediction only]; Region: COG0431 1198676000330 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 1198676000331 pyruvate dehydrogenase E1 component, alpha subunit; Region: PDH_E1_alph_y; TIGR03182 1198676000332 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 1198676000333 tetramer interface [polypeptide binding]; other site 1198676000334 TPP-binding site [chemical binding]; other site 1198676000335 heterodimer interface [polypeptide binding]; other site 1198676000336 phosphorylation loop region [posttranslational modification] 1198676000337 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 1198676000338 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 1198676000339 alpha subunit interface [polypeptide binding]; other site 1198676000340 TPP binding site [chemical binding]; other site 1198676000341 heterodimer interface [polypeptide binding]; other site 1198676000342 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 1198676000343 branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856 1198676000344 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 1198676000345 E3 interaction surface; other site 1198676000346 lipoyl attachment site [posttranslational modification]; other site 1198676000347 e3 binding domain; Region: E3_binding; pfam02817 1198676000348 e3 binding domain; Region: E3_binding; pfam02817 1198676000349 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 1198676000350 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 1198676000351 E3 interaction surface; other site 1198676000352 lipoyl attachment site [posttranslational modification]; other site 1198676000353 dihydrolipoamide dehydrogenase; Region: lipoamide_DH; TIGR01350 1198676000354 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1198676000355 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 1198676000356 Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095 1198676000357 lipoyltransferase and lipoate-protein ligase; Region: lipoyltrans; TIGR00545 1198676000358 Bacterial lipoate protein ligase C-terminus; Region: Lip_prot_lig_C; pfam10437 1198676000359 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 1198676000360 M20 Peptidase Aminoacyclase-1 YxeP-like proteins, including YxeP, YtnL, YjiB and HipO2; Region: M20_Acy1_YxeP_like; cd05669 1198676000361 metal binding site [ion binding]; metal-binding site 1198676000362 dimer interface [polypeptide binding]; other site 1198676000363 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1198676000364 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1198676000365 putative substrate translocation pore; other site 1198676000366 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1198676000367 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1198676000368 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1198676000369 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1198676000370 The substrate binding domain of LysR-type transcriptional regulator MleR which required for malolactic fermentation, contains type 2 periplasmic binidning fold; Region: PBP2_MleR; cd08437 1198676000371 putative dimerization interface [polypeptide binding]; other site 1198676000372 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1198676000373 non-specific DNA binding site [nucleotide binding]; other site 1198676000374 salt bridge; other site 1198676000375 sequence-specific DNA binding site [nucleotide binding]; other site 1198676000376 malate dehydrogenase; Provisional; Region: PRK13529 1198676000377 Malic enzyme, N-terminal domain; Region: malic; pfam00390 1198676000378 NAD(P) binding domain of malic enzyme (ME), subgroup 1; Region: NAD_bind_1_malic_enz; cd05312 1198676000379 NAD(P) binding site [chemical binding]; other site 1198676000380 Membrane transport protein; Region: Mem_trans; cl09117 1198676000381 bicupin, oxalate decarboxylase family; Region: bicupin_oxalic; TIGR03404 1198676000382 Cupin; Region: Cupin_1; smart00835 1198676000383 Cupin; Region: Cupin_1; smart00835 1198676000384 Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes [Energy production and conversion]; Region: Lpd; COG1249 1198676000385 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1198676000386 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 1198676000387 Protein of unknown function (DUF1275); Region: DUF1275; pfam06912 1198676000388 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 1198676000389 active site 1198676000390 catalytic residues [active] 1198676000391 metal binding site [ion binding]; metal-binding site 1198676000392 DNA-binding transcriptional activator YeiL; Provisional; Region: PRK10402 1198676000393 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 1198676000394 ligand binding site [chemical binding]; other site 1198676000395 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cl17320 1198676000396 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1198676000397 bifunctional acetaldehyde-CoA/alcohol dehydrogenase; Provisional; Region: PRK13805 1198676000398 Coenzyme A acylating aldehyde dehydrogenase (ACDH), ALDH family 20-like; Region: ALDH_F20_ACDH; cd07122 1198676000399 putative catalytic cysteine [active] 1198676000400 C-terminal alcohol dehydrogenase domain of the acetaldehyde dehydrogenase-alcohol dehydrogenase bifunctional two-domain protein (AAD); Region: AAD_C; cd08178 1198676000401 putative active site [active] 1198676000402 metal binding site [ion binding]; metal-binding site 1198676000403 Transposase IS200 like; Region: Y1_Tnp; pfam01797 1198676000404 Bacteriocin class II with double-glycine leader peptide; Region: Bacteriocin_IIc; pfam10439 1198676000405 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 1198676000406 Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353 1198676000407 16S/18S rRNA binding site [nucleotide binding]; other site 1198676000408 S13e-L30e interaction site [polypeptide binding]; other site 1198676000409 25S rRNA binding site [nucleotide binding]; other site 1198676000410 polynucleotide phosphorylase/polyadenylase; Provisional; Region: PRK11824 1198676000411 Polyribonucleotide nucleotidyltransferase, repeat 1; Region: RNase_PH_PNPase_1; cd11363 1198676000412 RNase E interface [polypeptide binding]; other site 1198676000413 trimer interface [polypeptide binding]; other site 1198676000414 Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364 1198676000415 RNase E interface [polypeptide binding]; other site 1198676000416 trimer interface [polypeptide binding]; other site 1198676000417 active site 1198676000418 Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393 1198676000419 S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472 1198676000420 RNA binding site [nucleotide binding]; other site 1198676000421 Serine acetyltransferase [Amino acid transport and metabolism]; Region: CysE; COG1045 1198676000422 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354 1198676000423 trimer interface [polypeptide binding]; other site 1198676000424 active site 1198676000425 substrate binding site [chemical binding]; other site 1198676000426 cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260 1198676000427 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 1198676000428 active site 1198676000429 HIGH motif; other site 1198676000430 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 1198676000431 KMSKS motif; other site 1198676000432 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 1198676000433 tRNA binding surface [nucleotide binding]; other site 1198676000434 anticodon binding site; other site 1198676000435 Ribonuclease III family protein [Replication, recombination, and repair]; Region: COG1939 1198676000436 active site 1198676000437 metal binding site [ion binding]; metal-binding site 1198676000438 dimerization interface [polypeptide binding]; other site 1198676000439 Predicted Zn-dependent protease (DUF2268); Region: DUF2268; pfam10026 1198676000440 Helix-Turn-Helix DNA binding domain of the transcription regulators TipAL, Mta, and SkgA; Region: HTH_TipAL-Mta; cd01106 1198676000441 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 1198676000442 DNA binding residues [nucleotide binding] 1198676000443 dimer interface [polypeptide binding]; other site 1198676000444 TipAS antibiotic-recognition domain; Region: TipAS; pfam07739 1198676000445 A predicted NlpC/p60-like peptidase; Region: BtrH; pfam14399 1198676000446 Predicted transcriptional regulators [Transcription]; Region: COG1695 1198676000447 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 1198676000448 rRNA methylase, putative, group 3; Region: rRNA_methyl_3; TIGR00186 1198676000449 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032 1198676000450 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 1198676000451 EDD domain protein, DegV family; Region: DegV; TIGR00762 1198676000452 Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645 1198676000453 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1198676000454 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1198676000455 non-specific DNA binding site [nucleotide binding]; other site 1198676000456 salt bridge; other site 1198676000457 sequence-specific DNA binding site [nucleotide binding]; other site 1198676000458 Ribosomal protein L13. Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392 1198676000459 23S rRNA interface [nucleotide binding]; other site 1198676000460 L3 interface [polypeptide binding]; other site 1198676000461 30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132 1198676000462 Antidote-toxin recognition MazE; Region: Antitoxin-MazE; cl00877 1198676000463 PemK-like protein; Region: PemK; pfam02452 1198676000464 Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403 1198676000465 active site 1198676000466 NTP binding site [chemical binding]; other site 1198676000467 metal binding triad [ion binding]; metal-binding site 1198676000468 antibiotic binding site [chemical binding]; other site 1198676000469 DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; cl17880 1198676000470 Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; cl17295 1198676000471 Alpha/beta hydrolase of unknown function (DUF915); Region: DUF915; pfam06028 1198676000472 PGAP1-like protein; Region: PGAP1; pfam07819 1198676000473 Predicted flavoprotein [General function prediction only]; Region: COG0431 1198676000474 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 1198676000475 Predicted flavoprotein [General function prediction only]; Region: COG0431 1198676000476 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 1198676000477 FMN-binding domain; Region: FMN_bind; cl01081 1198676000478 flavocytochrome c; Region: flavo_cyto_c; TIGR01813 1198676000479 L-aspartate oxidase; Provisional; Region: PRK06175 1198676000480 potential frameshift: common BLAST hit: gi|387785355|ref|YP_006250451.1| putative mevalonate kinase 1198676000481 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 1198676000482 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 1198676000483 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 1198676000484 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1198676000485 ABC-ATPase subunit interface; other site 1198676000486 dimer interface [polypeptide binding]; other site 1198676000487 putative PBP binding regions; other site 1198676000488 Metal binding protein PsaA. These proteins have been shown to function as initial receptors in ABC transport of Mn2+ and as surface adhesins in some eubacterial species. They belong to the TroA superfamily of periplasmic metal binding proteins that...; Region: PsaA; cd01137 1198676000489 ABC-type metal ion transport system, periplasmic component/surface adhesin [Inorganic ion transport and metabolism]; Region: LraI; COG0803 1198676000490 metal binding site [ion binding]; metal-binding site 1198676000491 Iron dependent repressor, N-terminal DNA binding domain; Region: Fe_dep_repress; pfam01325 1198676000492 Helix-turn-helix diphteria tox regulatory element; Region: HTH_DTXR; smart00529 1198676000493 Iron dependent repressor, metal binding and dimerisation domain; Region: Fe_dep_repr_C; pfam02742 1198676000494 FeoA domain; Region: FeoA; pfam04023 1198676000495 putative TIM-barrel protein, nifR3 family; Region: nifR3_yhdG; TIGR00737 1198676000496 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 1198676000497 FMN binding site [chemical binding]; other site 1198676000498 active site 1198676000499 catalytic residues [active] 1198676000500 substrate binding site [chemical binding]; other site 1198676000501 Hsp33-like chaperonin; Reviewed; Region: hslO; PRK00114 1198676000502 Heat shock protein 33 (Hsp33): Cytosolic protein that acts as a molecular chaperone under oxidative conditions. In normal (reducing) cytosolic conditions, four conserved Cys residues are coordinated by a Zn ion. Under oxidative stress (such as heat...; Region: Hsp33; cd00498 1198676000503 dimerization interface [polypeptide binding]; other site 1198676000504 domain crossover interface; other site 1198676000505 redox-dependent activation switch; other site 1198676000506 Domain of unknown function (DUF1795); Region: DUF1795; cl02256 1198676000507 phiLC3 phage and phage-related integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes various bacterial (mainly gram positive) and phage integrases, including those similar to Lactococcus...; Region: INT_phiLC3_C; cd01189 1198676000508 Int/Topo IB signature motif; other site 1198676000509 Domain of unknown function (DUF771); Region: DUF771; cl09962 1198676000510 phosphoglycolate phosphatase; Provisional; Region: PRK01158 1198676000511 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 1198676000512 Transposase DDE domain; Region: DDE_Tnp_1_3; pfam13612 1198676000513 Putative protein-S-isoprenylcysteine methyltransferase [Posttranslational modification, protein turnover, chaperones]; Region: STE14; COG2020 1198676000514 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1302 1198676000515 DAK2 domain fusion protein YloV; Region: YloV; TIGR03599 1198676000516 DAK2 domain; Region: Dak2; pfam02734 1198676000517 acetolactate synthase catalytic subunit; Reviewed; Region: PRK07282 1198676000518 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 1198676000519 PYR/PP interface [polypeptide binding]; other site 1198676000520 dimer interface [polypeptide binding]; other site 1198676000521 TPP binding site [chemical binding]; other site 1198676000522 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 1198676000523 Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015 1198676000524 TPP-binding site [chemical binding]; other site 1198676000525 dimer interface [polypeptide binding]; other site 1198676000526 acetolactate synthase 3 regulatory subunit; Reviewed; Region: ilvH; PRK11895 1198676000527 N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878 1198676000528 putative valine binding site [chemical binding]; other site 1198676000529 dimer interface [polypeptide binding]; other site 1198676000530 Small subunit of acetolactate synthase; Region: ALS_ss_C; pfam10369 1198676000531 ketol-acid reductoisomerase; Provisional; Region: PRK05479 1198676000532 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvN; pfam07991 1198676000533 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450 1198676000534 threonine dehydratase; Validated; Region: PRK08639 1198676000535 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 1198676000536 tetramer interface [polypeptide binding]; other site 1198676000537 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1198676000538 catalytic residue [active] 1198676000539 C-terminal regulatory domain of Threonine dehydratase; Region: Thr_dehydrat_C; pfam00585 1198676000540 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 1198676000541 A subgroup of the band 7 domain of flotillin (reggie) like proteins. This subgroup contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin. Many of these band 7 domain-containing proteins are lipid raft-associated. Individual...; Region: Band_7_4; cd03407 1198676000542 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1198676000543 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1198676000544 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 1198676000545 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 1198676000546 potential frameshift: common BLAST hit: gi|387786910|ref|YP_006252006.1| ABC transporter ATP-binding protein 1198676000547 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 1198676000548 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 1198676000549 Walker A/P-loop; other site 1198676000550 ATP binding site [chemical binding]; other site 1198676000551 Q-loop/lid; other site 1198676000552 ABC transporter signature motif; other site 1198676000553 Walker B; other site 1198676000554 D-loop; other site 1198676000555 H-loop/switch region; other site 1198676000556 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1198676000557 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 1198676000558 substrate binding pocket [chemical binding]; other site 1198676000559 membrane-bound complex binding site; other site 1198676000560 hinge residues; other site 1198676000561 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1198676000562 dimer interface [polypeptide binding]; other site 1198676000563 conserved gate region; other site 1198676000564 putative PBP binding loops; other site 1198676000565 ABC-ATPase subunit interface; other site 1198676000566 Predicted membrane protein (DUF2207); Region: DUF2207; pfam09972 1198676000567 undecaprenyl pyrophosphate phosphatase; Reviewed; Region: PRK00281 1198676000568 adaptor protein; Provisional; Region: PRK02315 1198676000569 UDP-N-acetylmuramyl pentapeptide phosphotransferase/UDP-N- acetylglucosamine-1-phosphate transferase [Cell envelope biogenesis, outer membrane]; Region: Rfe; COG0472 1198676000570 This subfamily contains Escherichia coli WecA, Bacillus subtilis TagO and related proteins. WecA is an UDP-N-acetylglucosamine (GlcNAc):undecaprenyl-phosphate (Und-P) GlcNAc-1-phosphate transferase that catalyzes the formation of a phosphodiester bond...; Region: GT_WecA_like; cd06853 1198676000571 Mg++ binding site [ion binding]; other site 1198676000572 putative catalytic motif [active] 1198676000573 substrate binding site [chemical binding]; other site 1198676000574 Cysteine desulfurase activator ATPase [Posttranslational modification, protein turnover, chaperones]; Region: sufC; COG0396 1198676000575 ABC-type transport system involved in Fe-S cluster assembly, ATPase component; Region: ABC_FeS_Assembly; cd03217 1198676000576 Walker A/P-loop; other site 1198676000577 ATP binding site [chemical binding]; other site 1198676000578 Q-loop/lid; other site 1198676000579 ABC transporter signature motif; other site 1198676000580 Walker B; other site 1198676000581 D-loop; other site 1198676000582 H-loop/switch region; other site 1198676000583 Cysteine desulfurase activator SufB [Posttranslational modification, protein turnover, chaperones]; Region: SufB; COG0719 1198676000584 cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814; cl03223 1198676000585 FeS assembly protein SufD; Region: sufD; TIGR01981 1198676000586 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 1198676000587 Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453 1198676000588 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1198676000589 catalytic residue [active] 1198676000590 NifU homolog involved in Fe-S cluster formation [Energy production and conversion]; Region: IscU; COG0822 1198676000591 Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664 1198676000592 trimerization site [polypeptide binding]; other site 1198676000593 active site 1198676000594 cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814; cl03223 1198676000595 FeS assembly protein SufB; Region: sufB; TIGR01980 1198676000596 D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768 1198676000597 Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; cl06814 1198676000598 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 1198676000599 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 1198676000600 peptide binding site [polypeptide binding]; other site 1198676000601 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 1198676000602 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1198676000603 dimer interface [polypeptide binding]; other site 1198676000604 conserved gate region; other site 1198676000605 putative PBP binding loops; other site 1198676000606 ABC-ATPase subunit interface; other site 1198676000607 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 1198676000608 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 1198676000609 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1198676000610 dimer interface [polypeptide binding]; other site 1198676000611 conserved gate region; other site 1198676000612 putative PBP binding loops; other site 1198676000613 ABC-ATPase subunit interface; other site 1198676000614 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 1198676000615 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1198676000616 Walker A/P-loop; other site 1198676000617 ATP binding site [chemical binding]; other site 1198676000618 Q-loop/lid; other site 1198676000619 ABC transporter signature motif; other site 1198676000620 Walker B; other site 1198676000621 D-loop; other site 1198676000622 H-loop/switch region; other site 1198676000623 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 1198676000624 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 1198676000625 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1198676000626 Walker A/P-loop; other site 1198676000627 ATP binding site [chemical binding]; other site 1198676000628 Q-loop/lid; other site 1198676000629 ABC transporter signature motif; other site 1198676000630 Walker B; other site 1198676000631 D-loop; other site 1198676000632 H-loop/switch region; other site 1198676000633 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352 1198676000634 Nitroreductase-like family 4. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_4; cd02140 1198676000635 dimer interface [polypeptide binding]; other site 1198676000636 FMN binding site [chemical binding]; other site 1198676000637 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1198676000638 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1198676000639 DNA binding residues [nucleotide binding] 1198676000640 dimerization interface [polypeptide binding]; other site 1198676000641 putrescine carbamoyltransferase; Provisional; Region: PRK02255 1198676000642 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 1198676000643 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 1198676000644 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 1198676000645 agmatine deiminase; Provisional; Region: PRK13551 1198676000646 agmatine deiminase; Region: agmatine_aguA; TIGR03380 1198676000647 carbamate kinase; Reviewed; Region: PRK12686 1198676000648 AAK_CK: Carbamate kinase (CK) catalyzes both the ATP-phosphorylation of carbamate and carbamoyl phosphate (CP) utilization with the production of ATP from ADP and CP. Both CK (this CD) and nonhomologous CP synthetase synthesize carbamoyl phosphate, an...; Region: AAK_CK; cd04235 1198676000649 putative substrate binding site [chemical binding]; other site 1198676000650 nucleotide binding site [chemical binding]; other site 1198676000651 nucleotide binding site [chemical binding]; other site 1198676000652 homodimer interface [polypeptide binding]; other site 1198676000653 bifunctional glutamate--cysteine ligase/glutathione synthetase; Provisional; Region: PRK02471 1198676000654 Glutamate-cysteine ligase; Region: Glu_cys_ligase; cl17352 1198676000655 ATP-grasp domain; Region: ATP-grasp_4; cl17255 1198676000656 Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788 1198676000657 Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108 1198676000658 GDP-binding site [chemical binding]; other site 1198676000659 ACT binding site; other site 1198676000660 IMP binding site; other site 1198676000661 potential frameshift: common BLAST hit: gi|387786882|ref|YP_006251978.1| PTS system ascorbate-specific transporter subunit IIC 1198676000662 PTS_IIB_ascorbate: subunit IIB of enzyme II (EII) of the L-ascorbate-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is an L-ascorbate-specific permease with two cytoplasmic subunits (IIA and IIB) and a...; Region: PTS_IIB_ascorbate; cd05563 1198676000663 active site 1198676000664 P-loop; other site 1198676000665 phosphorylation site [posttranslational modification] 1198676000666 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 1198676000667 active site 1198676000668 phosphorylation site [posttranslational modification] 1198676000669 3-Keto-L-gulonate 6-phosphate decarboxylase (KGPDC) and D-arabino-3-hexulose-6-phosphate synthase (HPS). KGPDC catalyzes the formation of L-xylulose 5-phosphate and carbon dioxide from 3-keto-L-gulonate 6-phosphate as part of the anaerobic pathway for...; Region: KGPDC_HPS; cd04726 1198676000670 active site 1198676000671 dimer interface [polypeptide binding]; other site 1198676000672 magnesium binding site [ion binding]; other site 1198676000673 putative L-xylulose 5-phosphate 3-epimerase; Reviewed; Region: PRK13210 1198676000674 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cd00019 1198676000675 AP (apurinic/apyrimidinic) site pocket; other site 1198676000676 DNA interaction; other site 1198676000677 Metal-binding active site; metal-binding site 1198676000678 L-ribulose-5-phosphate 4-epimerase; Provisional; Region: araD; PRK13145 1198676000679 L-ribulose-5-phosphate 4-epimerase; Reviewed; Region: araD; PRK08193 1198676000680 intersubunit interface [polypeptide binding]; other site 1198676000681 active site 1198676000682 Zn2+ binding site [ion binding]; other site 1198676000683 A sub-family of peptidase family C39. Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various...; Region: Peptidase_C39B; cd02418 1198676000684 ABC-type bacteriocin transporter; Region: bacteriocin_ABC; TIGR01193 1198676000685 putative active site [active] 1198676000686 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1198676000687 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1198676000688 Walker A/P-loop; other site 1198676000689 ATP binding site [chemical binding]; other site 1198676000690 Q-loop/lid; other site 1198676000691 ABC transporter signature motif; other site 1198676000692 Walker B; other site 1198676000693 D-loop; other site 1198676000694 H-loop/switch region; other site 1198676000695 bacteriocin secretion accessory protein; Region: bacteriocin_acc; TIGR01000 1198676000696 bacteriocin secretion accessory protein; Region: bacteriocin_acc; TIGR01000 1198676000697 Transcriptional antiterminator [Transcription]; Region: BglG; COG3711 1198676000698 PRD domain; Region: PRD; pfam00874 1198676000699 PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568 1198676000700 active site 1198676000701 P-loop; other site 1198676000702 phosphorylation site [posttranslational modification] 1198676000703 putative L-ascorbate 6-phosphate lactonase; Provisional; Region: PRK11709 1198676000704 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 1198676000705 Transketolase [Carbohydrate transport and metabolism]; Region: TktA; COG0021 1198676000706 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 1198676000707 TPP-binding site [chemical binding]; other site 1198676000708 dimer interface [polypeptide binding]; other site 1198676000709 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 1198676000710 PYR/PP interface [polypeptide binding]; other site 1198676000711 dimer interface [polypeptide binding]; other site 1198676000712 TPP binding site [chemical binding]; other site 1198676000713 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 1198676000714 Arabinose-binding domain of AraC transcription regulator, N-term; Region: Arabinose_bd; pfam12625 1198676000715 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1198676000716 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1198676000717 Protein of unknown function with HXXEE motif; Region: HXXEE; pfam13787 1198676000718 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 1198676000719 LytTr DNA-binding domain; Region: LytTR; pfam04397 1198676000720 Ketopantoate reductase [Coenzyme metabolism]; Region: ApbA; COG1893 1198676000721 Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558 1198676000722 DNA polymerase I; Provisional; Region: PRK05755 1198676000723 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 1198676000724 active site 1198676000725 metal binding site 1 [ion binding]; metal-binding site 1198676000726 putative 5' ssDNA interaction site; other site 1198676000727 metal binding site 3; metal-binding site 1198676000728 metal binding site 2 [ion binding]; metal-binding site 1198676000729 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 1198676000730 putative DNA binding site [nucleotide binding]; other site 1198676000731 putative metal binding site [ion binding]; other site 1198676000732 inactive DEDDy 3'-5' exonuclease domain of Bacillus stearothermophilus DNA polymerase I and similar family-A DNA polymerases; Region: DNA_polA_I_Bacillus_like_exo; cd06140 1198676000733 Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637 1198676000734 active site 1198676000735 DNA binding site [nucleotide binding] 1198676000736 catalytic site [active] 1198676000737 Predicted CoA-binding protein [General function prediction only]; Region: COG1832 1198676000738 Bacteriocin class II with double-glycine leader peptide; Region: Bacteriocin_IIc; pfam10439 1198676000739 queuine tRNA-ribosyltransferase; Provisional; Region: tgt; PRK00112 1198676000740 Queuine/archaeosine tRNA-ribosyltransferase [Translation, ribosomal structure and biogenesis]; Region: Tgt; COG0343 1198676000741 Bacterial protein of unknown function (DUF925); Region: DUF925; pfam06042 1198676000742 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 1198676000743 putative active site [active] 1198676000744 Metal-dependent hydrolases of the beta-lactamase superfamily III [General function prediction only]; Region: ElaC; COG1234 1198676000745 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 1198676000746 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 1198676000747 nucleoside/Zn binding site; other site 1198676000748 dimer interface [polypeptide binding]; other site 1198676000749 catalytic motif [active] 1198676000750 glucose-6-phosphate isomerase; Provisional; Region: pgi; PRK14097 1198676000751 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015 1198676000752 active site 1198676000753 dimer interface [polypeptide binding]; other site 1198676000754 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016 1198676000755 dimer interface [polypeptide binding]; other site 1198676000756 active site 1198676000757 sorbitol-6-phosphate 2-dehydrogenase; Provisional; Region: PRK06171 1198676000758 classical (c) SDRs; Region: SDR_c; cd05233 1198676000759 NAD(P) binding site [chemical binding]; other site 1198676000760 active site 1198676000761 putative frv operon regulatory protein; Provisional; Region: PRK09863 1198676000762 HTH domain; Region: HTH_11; pfam08279 1198676000763 PRD domain; Region: PRD; pfam00874 1198676000764 PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568 1198676000765 active site 1198676000766 P-loop; other site 1198676000767 phosphorylation site [posttranslational modification] 1198676000768 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 1198676000769 active site 1198676000770 phosphorylation site [posttranslational modification] 1198676000771 Glucitol operon activator protein (GutM); Region: GutM; pfam06923 1198676000772 PTS system enzyme II sorbitol-specific factor; Region: EII-GUT; pfam03608 1198676000773 Sorbitol phosphotransferase enzyme II N-terminus; Region: EIIBC-GUT_N; pfam03612 1198676000774 PTS system, glucitol/sorbitol-specific, IIBC component; Region: EIIBC-GUT; TIGR00825 1198676000775 Sorbitol phosphotransferase enzyme II C-terminus; Region: EIIBC-GUT_C; pfam07663 1198676000776 PTS system glucitol/sorbitol-specific IIA component; Region: PTSIIA_gutA; pfam03829 1198676000777 Class I aldolases; Region: Aldolase_Class_I; cl17187 1198676000778 Class I aldolases; Region: Aldolase_Class_I; cl17187 1198676000779 catalytic residue [active] 1198676000780 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-acetyltransferase; Region: DapD_Ac; TIGR03532 1198676000781 Tetrahydrodipicolinate succinyltransferase N-terminal; Region: DapH_N; pfam08503 1198676000782 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 1198676000783 putative trimer interface [polypeptide binding]; other site 1198676000784 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 1198676000785 putative CoA binding site [chemical binding]; other site 1198676000786 putative trimer interface [polypeptide binding]; other site 1198676000787 putative CoA binding site [chemical binding]; other site 1198676000788 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 1198676000789 M20 Peptidase Aminoacyclase-1 YkuR-like proteins, including YkuR and Ama/HipO/HyuC proteins; Region: M20_Acy1_YkuR_like; cd05670 1198676000790 metal binding site [ion binding]; metal-binding site 1198676000791 putative dimer interface [polypeptide binding]; other site 1198676000792 5-formyltetrahydrofolate cyclo-ligase family; Region: 5-FTHF_cyc-lig; pfam01812 1198676000793 5,10-methenyltetrahydrofolate synthetase; Region: MTHFS_bact; TIGR02727 1198676000794 Rhomboid family; Region: Rhomboid; pfam01694 1198676000795 Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541 1198676000796 dTDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: RfbA; COG1209 1198676000797 active site 1198676000798 tetramer interface; other site 1198676000799 NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094 1198676000800 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 1198676000801 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479 1198676000802 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 1198676000803 trimer interface [polypeptide binding]; other site 1198676000804 active site 1198676000805 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 1198676000806 catalytic triad [active] 1198676000807 conserved cis-peptide bond; other site 1198676000808 DNA repair protein RadA; Provisional; Region: PRK11823 1198676000809 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 1198676000810 Walker A motif; other site 1198676000811 ATP binding site [chemical binding]; other site 1198676000812 Walker B motif; other site 1198676000813 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 1198676000814 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeD; cd03379 1198676000815 active site clefts [active] 1198676000816 zinc binding site [ion binding]; other site 1198676000817 dimer interface [polypeptide binding]; other site 1198676000818 Uncharacterized conserved protein [Function unknown]; Region: COG2013 1198676000819 glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406 1198676000820 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 1198676000821 active site 1198676000822 HIGH motif; other site 1198676000823 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 1198676000824 active site 1198676000825 KMSKS motif; other site 1198676000826 Predicted small molecule binding protein (contains 3H domain) [General function prediction only]; Region: COG1827 1198676000827 HTH domain; Region: HTH_11; pfam08279 1198676000828 3H domain; Region: 3H; pfam02829 1198676000829 Predicted membrane protein (DUF2232); Region: DUF2232; cl01728 1198676000830 argininosuccinate synthase; Provisional; Region: PRK13820 1198676000831 Argininosuccinate synthase. The Argininosuccinate synthase is a urea cycle enzyme that catalyzes the penultimate step in arginine biosynthesis: the ATP-dependent ligation of citrulline to aspartate to form argininosuccinate, AMP and pyrophosphate . In...; Region: Argininosuccinate_Synthase; cd01999 1198676000832 ANP binding site [chemical binding]; other site 1198676000833 Substrate Binding Site II [chemical binding]; other site 1198676000834 Substrate Binding Site I [chemical binding]; other site 1198676000835 argininosuccinate lyase; Provisional; Region: PRK00855 1198676000836 Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359 1198676000837 active sites [active] 1198676000838 tetramer interface [polypeptide binding]; other site 1198676000839 ribonuclease P; Reviewed; Region: rnpA; PRK00499 1198676000840 Preprotein translocase subunit YidC [Intracellular trafficking and secretion]; Region: YidC; COG0706 1198676000841 membrane protein insertase, YidC/Oxa1 family, C-terminal domain; Region: yidC_oxa1_cterm; TIGR03592 1198676000842 Predicted RNA-binding protein [General function prediction only]; Region: Jag; COG1847 1198676000843 Predicted RNA-binding protein [General function prediction only]; Region: Jag; COG1847 1198676000844 jag_K homology RNA-binding domain. The KH domain is found in proteins homologous to the Bacillus subtilis protein Jag, which is associated with SpoIIIJ and is necessary for the third stage of sporulation. The KH motif is a beta-alpha-alpha-beta-beta...; Region: jag_KH; cd02414 1198676000845 G-X-X-G motif; other site 1198676000846 R3H domain found in proteins homologous to Bacillus subtilus Jag, which is associated with SpoIIIJ. SpoIIIJ is necessary for the third stage of sporulation. The name of the R3H domain comes from the characteristic spacing of the most conserved arginine...; Region: R3H_jag; cd02644 1198676000847 RxxxH motif; other site 1198676000848 Protein of unknown function (DUF998); Region: DUF998; pfam06197 1198676000849 Ribosomal protein L34; Region: Ribosomal_L34; cl00370 1198676000850 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 1198676000851 Predicted metal-dependent hydrolases with the TIM-barrel fold [General function prediction only]; Region: COG1099 1198676000852 active site 1198676000853 ribonuclease M5; Region: 5S_RNA_mat_M5; TIGR00334 1198676000854 TOPRIM_ RNase M5_like: The topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain found in Ribonuclease M5: (RNase M5) and other small primase-like proteins from bacteria and archaea. RNase M5 catalyzes the maturation of 5S rRNA in low...; Region: TOPRIM_RNase_M5_like; cd01027 1198676000855 putative active site [active] 1198676000856 putative metal binding site [ion binding]; other site 1198676000857 Domain of unknown function (DUF4093); Region: DUF4093; pfam13331 1198676000858 Putative protein-S-isoprenylcysteine methyltransferase [Posttranslational modification, protein turnover, chaperones]; Region: STE14; COG2020 1198676000859 Protein of unknown function (DUF1697); Region: DUF1697; cl01557 1198676000860 Predicted transcriptional regulators [Transcription]; Region: COG1733 1198676000861 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 1198676000862 Nitroreductase-like family 1. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_1; cd02137 1198676000863 dimer interface [polypeptide binding]; other site 1198676000864 FMN binding site [chemical binding]; other site 1198676000865 Diadenosine tetraphosphate (Ap4A) hydrolase and other HIT family hydrolases [Nucleotide transport and metabolism / Carbohydrate transport and metabolism / General function prediction only]; Region: Hit; COG0537 1198676000866 nucleotide binding site/active site [active] 1198676000867 HIT family signature motif; other site 1198676000868 catalytic residue [active] 1198676000869 16S ribosomal RNA methyltransferase KsgA/Dim1 family protein; Reviewed; Region: ksgA; PRK00274 1198676000870 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1198676000871 S-adenosylmethionine binding site [chemical binding]; other site 1198676000872 GTPase RsgA; Reviewed; Region: PRK00098 1198676000873 S1_YloQ_GTPase: YloQ GTase family (also known as YjeQ and CpgA), S1-like RNA-binding domain. Proteins in the YloQ GTase family bind the ribosome and have GTPase activity. The precise role of this family is unknown. The protein structure is composed of...; Region: S1_YloQ_GTPase; cd04466 1198676000874 RNA binding site [nucleotide binding]; other site 1198676000875 homodimer interface [polypeptide binding]; other site 1198676000876 Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854 1198676000877 GTPase/Zn-binding domain interface [polypeptide binding]; other site 1198676000878 GTP/Mg2+ binding site [chemical binding]; other site 1198676000879 G4 box; other site 1198676000880 G1 box; other site 1198676000881 Switch I region; other site 1198676000882 G2 box; other site 1198676000883 G3 box; other site 1198676000884 Switch II region; other site 1198676000885 Pentose-5-phosphate-3-epimerase [Carbohydrate transport and metabolism]; Region: Rpe; COG0036 1198676000886 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 1198676000887 substrate binding site [chemical binding]; other site 1198676000888 hexamer interface [polypeptide binding]; other site 1198676000889 metal binding site [ion binding]; metal-binding site 1198676000890 Thiamine pyrophosphokinase [Coenzyme metabolism]; Region: THI80; COG1564 1198676000891 Thiamine pyrophosphokinase; Region: TPK; cd07995 1198676000892 active site 1198676000893 dimerization interface [polypeptide binding]; other site 1198676000894 thiamine binding site [chemical binding]; other site 1198676000895 Predicted nuclease of restriction endonuclease-like fold, RmuC family [General function prediction only]; Region: COG1322 1198676000896 RmuC family; Region: RmuC; pfam02646 1198676000897 Predicted HD-superfamily hydrolase [General function prediction only]; Region: COG3481 1198676000898 YhaM_OBF_like: A subfamily of OB folds similar to that found in Bacillus subtilis YhaM and Staphylococcus aureus cmp-binding factor-1 (SaCBF1). Both these proteins are 3'-to-5'exoribonucleases. YhaM requires Mn2+ or Co2+ for activity and is...; Region: YhaM_OBF_like; cd04492 1198676000899 generic binding surface II; other site 1198676000900 generic binding surface I; other site 1198676000901 integrating conjugative element relaxase, PFL_4751 family; Region: ICE_TraI_Pfluor; TIGR03760 1198676000902 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1198676000903 Zn2+ binding site [ion binding]; other site 1198676000904 Mg2+ binding site [ion binding]; other site 1198676000905 pur operon repressor; Provisional; Region: PRK09213 1198676000906 Bacterial purine repressor, N-terminal; Region: PuR_N; pfam09182 1198676000907 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1198676000908 active site 1198676000909 S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368 1198676000910 S17 interaction site [polypeptide binding]; other site 1198676000911 S8 interaction site; other site 1198676000912 16S rRNA interaction site [nucleotide binding]; other site 1198676000913 streptomycin interaction site [chemical binding]; other site 1198676000914 23S rRNA interaction site [nucleotide binding]; other site 1198676000915 aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site 1198676000916 30S ribosomal protein S7; Validated; Region: PRK05302 1198676000917 elongation factor G; Reviewed; Region: PRK00007 1198676000918 Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886 1198676000919 G1 box; other site 1198676000920 putative GEF interaction site [polypeptide binding]; other site 1198676000921 GTP/Mg2+ binding site [chemical binding]; other site 1198676000922 Switch I region; other site 1198676000923 G2 box; other site 1198676000924 G3 box; other site 1198676000925 Switch II region; other site 1198676000926 G4 box; other site 1198676000927 G5 box; other site 1198676000928 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 1198676000929 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 1198676000930 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 1198676000931 Glyceraldehyde-3-phosphate dehydrogenase/erythrose-4-phosphate dehydrogenase [Carbohydrate transport and metabolism]; Region: GapA; COG0057 1198676000932 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846 1198676000933 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 1198676000934 phosphoglycerate kinase; Provisional; Region: pgk; PRK00073 1198676000935 Phosphoglycerate kinase; Region: PGK; pfam00162 1198676000936 substrate binding site [chemical binding]; other site 1198676000937 hinge regions; other site 1198676000938 ADP binding site [chemical binding]; other site 1198676000939 catalytic site [active] 1198676000940 Predicted membrane protein [Function unknown]; Region: COG4129 1198676000941 Helix-Turn-Helix DNA binding domain of GlnR-like transcription regulators; Region: HTH_GlnR-like; cd01105 1198676000942 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 1198676000943 DNA binding residues [nucleotide binding] 1198676000944 putative dimer interface [polypeptide binding]; other site 1198676000945 Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174 1198676000946 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 1198676000947 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 1198676000948 glutamate synthase subunit alpha; Provisional; Region: gltB; PRK11750 1198676000949 Glutamine amidotransferases class-II (Gn-AT), glutamate synthase (GltS)-type. GltS is a homodimer that synthesizes L-glutamate from 2-oxoglutarate and L-glutamine, an important step in ammonia assimilation in bacteria, cyanobacteria and plants. The...; Region: GltS; cd00713 1198676000950 active site 1198676000951 dimer interface [polypeptide binding]; other site 1198676000952 Glutamate synthase central domain; Region: Glu_syn_central; pfam04898 1198676000953 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808 1198676000954 active site 1198676000955 FMN binding site [chemical binding]; other site 1198676000956 substrate binding site [chemical binding]; other site 1198676000957 3Fe-4S cluster binding site [ion binding]; other site 1198676000958 gltb_C. This domain is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS). GltS encodes a complex iron-sulfur flavoprotein that catalyzes the synthesis of L-glutamate from L-glutamine and 2-oxoglutarate. It requires the...; Region: gltB_C; cd00982 1198676000959 domain interface; other site 1198676000960 glutamate synthase subunit beta; Reviewed; Region: gltD; PRK12810 1198676000961 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 1198676000962 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1198676000963 Surface antigen [General function prediction only]; Region: COG3942 1198676000964 CHAP domain; Region: CHAP; pfam05257 1198676000965 mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595 1198676000966 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 1198676000967 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 1198676000968 hypothetical protein; Provisional; Region: PRK13667 1198676000969 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 1198676000970 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 1198676000971 Walker A/P-loop; other site 1198676000972 ATP binding site [chemical binding]; other site 1198676000973 Q-loop/lid; other site 1198676000974 ABC transporter signature motif; other site 1198676000975 Walker B; other site 1198676000976 D-loop; other site 1198676000977 H-loop/switch region; other site 1198676000978 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 1198676000979 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK06550 1198676000980 classical (c) SDRs; Region: SDR_c; cd05233 1198676000981 NAD(P) binding site [chemical binding]; other site 1198676000982 active site 1198676000983 Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020 1198676000984 active site 1198676000985 putative substrate binding region [chemical binding]; other site 1198676000986 Ornithine/acetylornithine aminotransferase [Amino acid transport and metabolism]; Region: ArgD; COG4992 1198676000987 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 1198676000988 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1198676000989 catalytic residue [active] 1198676000990 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1198676000991 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1198676000992 non-specific DNA binding site [nucleotide binding]; other site 1198676000993 salt bridge; other site 1198676000994 sequence-specific DNA binding site [nucleotide binding]; other site 1198676000995 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1198676000996 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1198676000997 active site 1198676000998 catalytic tetrad [active] 1198676000999 hopanoid-associated sugar epimerase; Region: HpnA; TIGR03466 1198676001000 uncharacterized subgroup of aldehyde reductase and flavonoid reductase related proteins, extended (e) SDRs; Region: AR_FR_like_1_SDR_e; cd05228 1198676001001 putative NADP binding site [chemical binding]; other site 1198676001002 putative substrate binding site [chemical binding]; other site 1198676001003 active site 1198676001004 Transcriptional regulators [Transcription]; Region: MarR; COG1846 1198676001005 MarR family; Region: MarR_2; pfam12802 1198676001006 tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725 1198676001007 Glycoprotease family; Region: Peptidase_M22; pfam00814 1198676001008 ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575 1198676001009 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1198676001010 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 1198676001011 Coenzyme A binding pocket [chemical binding]; other site 1198676001012 UGMP family protein; Validated; Region: PRK09604 1198676001013 Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214; cl17884 1198676001014 Carbamoyltransferase; Region: CmcH_NodU; pfam02543 1198676001015 Predicted branched-chain amino acid permease (azaleucine resistance) [Amino acid transport and metabolism]; Region: AzlC; COG1296 1198676001016 Predicted membrane protein [Function unknown]; Region: COG4392 1198676001017 Protein of unknown function (DUF2992); Region: DUF2992; pfam11208 1198676001018 HI0933-like protein; Region: HI0933_like; pfam03486 1198676001019 Protein of unknown function, DUF536; Region: DUF536; pfam04394 1198676001020 hypothetical protein; Validated; Region: PRK00153 1198676001021 integrase; Provisional; Region: int; PHA02601 1198676001022 phiLC3 phage and phage-related integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes various bacterial (mainly gram positive) and phage integrases, including those similar to Lactococcus...; Region: INT_phiLC3_C; cd01189 1198676001023 Int/Topo IB signature motif; other site 1198676001024 Domain of unknown function (DUF3173); Region: DUF3173; pfam11372 1198676001025 Plasmid replication protein; Region: Rep_2; pfam01719 1198676001026 Integrase core domain; Region: rve; pfam00665 1198676001027 Integrase core domain; Region: rve_2; pfam13333 1198676001028 potential frameshift: common BLAST hit: gi|325977424|ref|YP_004287140.1| prolyl-tRNA synthetase 1198676001029 prolyl-tRNA synthetase; Provisional; Region: PRK09194 1198676001030 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 1198676001031 motif 1; other site 1198676001032 dimer interface [polypeptide binding]; other site 1198676001033 active site 1198676001034 motif 2; other site 1198676001035 INS is an amino acid-editing domain inserted (INS) into the bacterial class II prolyl-tRNA synthetase (ProRS) however, this CD is not exclusively bacterial. It is also found at the N-terminus of the eukaryotic/archaea-like ProRS's of yeasts and...; Region: ProRS-INS; cd04334 1198676001036 putative deacylase active site [active] 1198676001037 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 1198676001038 motif 3; other site 1198676001039 HGTP anticodon binding domain, as found at the C-terminus of histidyl, glycyl, threonyl and prolyl tRNA synthetases, which are classified as a group of class II aminoacyl-tRNA synthetases (aaRS). In aaRSs, the anticodon binding domain is responsible for...; Region: HGTP_anticodon; cl00266 1198676001040 anticodon binding site; other site 1198676001041 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1198676001042 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1198676001043 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 1198676001044 dimerization interface [polypeptide binding]; other site 1198676001045 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 1198676001046 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1198676001047 catalytic residue [active] 1198676001048 Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711 1198676001049 AMP-binding enzyme; Region: AMP-binding; pfam00501 1198676001050 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1198676001051 active site 1198676001052 AMP binding site [chemical binding]; other site 1198676001053 acyl-activating enzyme (AAE) consensus motif; other site 1198676001054 CoA binding site [chemical binding]; other site 1198676001055 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 1198676001056 EamA-like transporter family; Region: EamA; pfam00892 1198676001057 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846 1198676001058 glyceraldehyde-3-phosphate dehydrogenase, type I; Region: GAPDH-I; TIGR01534 1198676001059 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 1198676001060 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016 1198676001061 Transposase IS200 like; Region: Y1_Tnp; pfam01797 1198676001062 x-prolyl-dipeptidyl aminopeptidase; Provisional; Region: PRK05371 1198676001063 X-Prolyl dipeptidyl aminopeptidase PepX, N-terminal; Region: PepX_N; pfam09168 1198676001064 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 1198676001065 X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain; Region: PepX_C; pfam08530 1198676001066 Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cd00333 1198676001067 amphipathic channel; other site 1198676001068 Asn-Pro-Ala signature motifs; other site 1198676001069 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 1198676001070 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 1198676001071 Beta-lactamase; Region: Beta-lactamase; pfam00144 1198676001072 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1198676001073 Coenzyme A binding pocket [chemical binding]; other site 1198676001074 formate acetyltransferase 1; Region: pyr_form_ly_1; TIGR01255 1198676001075 Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939 1198676001076 DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586 1198676001077 active site 1198676001078 DNA polymerase IV; Validated; Region: PRK02406 1198676001079 DNA binding site [nucleotide binding] 1198676001080 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1198676001081 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1198676001082 non-specific DNA binding site [nucleotide binding]; other site 1198676001083 salt bridge; other site 1198676001084 sequence-specific DNA binding site [nucleotide binding]; other site 1198676001085 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 1198676001086 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1198676001087 active site 1198676001088 motif I; other site 1198676001089 motif II; other site 1198676001090 Protein of unknown function (DUF1361); Region: DUF1361; pfam07099 1198676001091 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 1198676001092 Predicted ATPase or kinase [General function prediction only]; Region: COG0802 1198676001093 Transcriptional regulator [Transcription]; Region: LytR; COG1316 1198676001094 HINT (histidine triad nucleotide-binding protein) subgroup: Members of this CD belong to the superfamily of histidine triad hydrolases that act on alpha-phosphate of ribonucleotides. This subgroup includes members from all three forms of cellular life; Region: HINT_subgroup; cd01277 1198676001095 HIT family signature motif; other site 1198676001096 catalytic residue [active] 1198676001097 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 1198676001098 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 1198676001099 Walker A/P-loop; other site 1198676001100 ATP binding site [chemical binding]; other site 1198676001101 Q-loop/lid; other site 1198676001102 ABC transporter signature motif; other site 1198676001103 Walker B; other site 1198676001104 D-loop; other site 1198676001105 H-loop/switch region; other site 1198676001106 Bacterial ABC transporter protein EcsB; Region: EcsB; cl11542 1198676001107 Bacterial ABC transporter protein EcsB; Region: EcsB; pfam05975 1198676001108 Thiamine kinase and related kinases [Coenzyme transport and metabolism]; Region: ycfN; COG0510 1198676001109 Phosphotransferase enzyme family; Region: APH; pfam01636 1198676001110 substrate binding site [chemical binding]; other site 1198676001111 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1198676001112 S-adenosylmethionine binding site [chemical binding]; other site 1198676001113 ribosome maturation protein RimP; Reviewed; Region: PRK00092 1198676001114 Bacillus subtilis YxlS-like, C-terminal domain; Region: YlxS_C; cd01734 1198676001115 putative oligomer interface [polypeptide binding]; other site 1198676001116 putative RNA binding site [nucleotide binding]; other site 1198676001117 transcription elongation factor NusA; Provisional; Region: nusA; PRK12327 1198676001118 NusA N-terminal domain; Region: NusA_N; pfam08529 1198676001119 S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455 1198676001120 RNA binding site [nucleotide binding]; other site 1198676001121 homodimer interface [polypeptide binding]; other site 1198676001122 NusA-like KH domain; Region: KH_5; pfam13184 1198676001123 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 1198676001124 G-X-X-G motif; other site 1198676001125 Ylxr homologs; group of conserved hypothetical bacterial proteins of unknown function; structure revealed putative RNA binding cleft; proteins are encoded by an operon that includes other proteins involved in transcription and/or translation; Region: YlxR; cd00279 1198676001126 putative RNA binding cleft [nucleotide binding]; other site 1198676001127 hypothetical protein; Provisional; Region: PRK07283 1198676001128 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 1198676001129 translation initiation factor IF-2; Region: IF-2; TIGR00487 1198676001130 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 1198676001131 Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887 1198676001132 G1 box; other site 1198676001133 putative GEF interaction site [polypeptide binding]; other site 1198676001134 GTP/Mg2+ binding site [chemical binding]; other site 1198676001135 Switch I region; other site 1198676001136 G2 box; other site 1198676001137 G3 box; other site 1198676001138 Switch II region; other site 1198676001139 G4 box; other site 1198676001140 G5 box; other site 1198676001141 This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702 1198676001142 Translation-initiation factor 2; Region: IF-2; pfam11987 1198676001143 mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692 1198676001144 ribosome-binding factor A; Validated; Region: rbfA; PRK00521 1198676001145 Bacteriocin class II with double-glycine leader peptide; Region: Bacteriocin_IIc; pfam10439 1198676001146 copper transport repressor, CopY/TcrY family; Region: CopY_TcrY; TIGR02698 1198676001147 Penicillinase repressor; Region: Pencillinase_R; pfam03965 1198676001148 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 1198676001149 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 1198676001150 metal-binding site [ion binding] 1198676001151 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 1198676001152 Soluble P-type ATPase [General function prediction only]; Region: COG4087 1198676001153 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cl00207 1198676001154 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1198676001155 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 1198676001156 active site 1198676001157 motif I; other site 1198676001158 motif II; other site 1198676001159 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1198676001160 Bacterial inner membrane protein; Region: Imp-YgjV; pfam10688 1198676001161 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 1198676001162 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1198676001163 Walker A/P-loop; other site 1198676001164 ATP binding site [chemical binding]; other site 1198676001165 Q-loop/lid; other site 1198676001166 ABC transporter signature motif; other site 1198676001167 Walker B; other site 1198676001168 D-loop; other site 1198676001169 H-loop/switch region; other site 1198676001170 Domain of unknown function (DUF4162); Region: DUF4162; pfam13732 1198676001171 ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698 1198676001172 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 1198676001173 LytTr DNA-binding domain; Region: LytTR; pfam04397 1198676001174 Protein of unknown function (DUF3021); Region: DUF3021; pfam11457 1198676001175 N-acetylglucosamine-6-phosphate deacetylase [Carbohydrate transport and metabolism]; Region: NagA; COG1820 1198676001176 N-acetylglucosamine-6-phosphate deacetylase, NagA, catalyzes the hydrolysis of the N-acetyl group of N-acetyl-glucosamine-6-phosphate (GlcNAc-6-P) to glucosamine 6-phosphate and acetate. This is the first committed step in the biosynthetic pathway to...; Region: NagA; cd00854 1198676001177 active site 1198676001178 dimer interface [polypeptide binding]; other site 1198676001179 BadF/BadG/BcrA/BcrD ATPase family; Region: BcrAD_BadFG; cl17271 1198676001180 Activator of 2-hydroxyglutaryl-CoA dehydratase (HSP70-class ATPase domain) [Lipid metabolism]; Region: COG1924 1198676001181 BadF/BadG/BcrA/BcrD ATPase family; Region: BcrAD_BadFG; cl17271 1198676001182 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3580 1198676001183 2-hydroxyglutaryl-CoA dehydratase, D-component; Region: HGD-D; pfam06050 1198676001184 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3581 1198676001185 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1198676001186 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1198676001187 Ligand-binding SRPBCC domain of Streptococcus mutans Smu.440 and related proteins; Region: SRPBCC_Smu440-like; cd08862 1198676001188 putative hydrophobic ligand binding site [chemical binding]; other site 1198676001189 Transcriptional regulators [Transcription]; Region: MarR; COG1846 1198676001190 MarR family; Region: MarR; pfam01047 1198676001191 MarR family; Region: MarR_2; cl17246 1198676001192 hypothetical protein; Provisional; Region: PRK02268 1198676001193 Class II Glycyl-tRNA synthetase (GlyRS) alpha subunit core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes and in arabidopsis. It is responsible for the...; Region: GlyRS_alpha_core; cd00733 1198676001194 dimer interface [polypeptide binding]; other site 1198676001195 motif 1; other site 1198676001196 active site 1198676001197 motif 2; other site 1198676001198 motif 3; other site 1198676001199 glycyl-tRNA synthetase subunit beta; Validated; Region: glyS; PRK01233 1198676001200 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; smart00471 1198676001201 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 1198676001202 hypothetical protein; Provisional; Region: PRK02539 1198676001203 Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413 1198676001204 Glutamate 5-kinase [Amino acid transport and metabolism]; Region: ProB; COG0263 1198676001205 AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242 1198676001206 nucleotide binding site [chemical binding]; other site 1198676001207 homotetrameric interface [polypeptide binding]; other site 1198676001208 putative phosphate binding site [ion binding]; other site 1198676001209 putative allosteric binding site; other site 1198676001210 Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079 1198676001211 gamma-glutamyl phosphate reductase; Region: proA; TIGR00407 1198676001212 putative catalytic cysteine [active] 1198676001213 MraW methylase family; Region: Methyltransf_5; pfam01795 1198676001214 16S rRNA m(4)C1402 methyltranserfase; Provisional; Region: PRK00050 1198676001215 Protein required for the initiation of cell division [Cell division and chromosome partitioning]; Region: FtsL; COG4839 1198676001216 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 1198676001217 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 1198676001218 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 1198676001219 PASTA domain of PBP2x-like proteins, first repeat. Penicillin-binding proteins (PBPs) are the major targets for beta-lactam antibiotics, like penicillins and cephalosporins. Beta-lactam antibiotics specifically inhibit transpeptidase activity by...; Region: PASTA_Pbp2x-like_1; cd06576 1198676001220 PASTA domain of PBP2x-like proteins, second repeat. Penicillin-binding proteins (PBPs) are the major targets for beta-lactam antibiotics, like penicillins and cephalosporins. Beta-lactam antibiotics specifically inhibit transpeptidase activity by...; Region: PASTA_Pbp2x-like_2; cd06575 1198676001221 phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108 1198676001222 Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852 1198676001223 Mg++ binding site [ion binding]; other site 1198676001224 putative catalytic motif [active] 1198676001225 putative substrate binding site [chemical binding]; other site 1198676001226 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 1198676001227 DEAD-like helicases superfamily; Region: DEXDc; smart00487 1198676001228 ATP binding site [chemical binding]; other site 1198676001229 Mg++ binding site [ion binding]; other site 1198676001230 motif III; other site 1198676001231 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1198676001232 nucleotide binding region [chemical binding]; other site 1198676001233 ATP-binding site [chemical binding]; other site 1198676001234 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1198676001235 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 1198676001236 substrate binding pocket [chemical binding]; other site 1198676001237 membrane-bound complex binding site; other site 1198676001238 hinge residues; other site 1198676001239 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 1198676001240 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1198676001241 dimer interface [polypeptide binding]; other site 1198676001242 conserved gate region; other site 1198676001243 putative PBP binding loops; other site 1198676001244 ABC-ATPase subunit interface; other site 1198676001245 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 1198676001246 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 1198676001247 Walker A/P-loop; other site 1198676001248 ATP binding site [chemical binding]; other site 1198676001249 Q-loop/lid; other site 1198676001250 ABC transporter signature motif; other site 1198676001251 Walker B; other site 1198676001252 D-loop; other site 1198676001253 H-loop/switch region; other site 1198676001254 Protein of unknown function (DUF4059); Region: DUF4059; pfam13268 1198676001255 thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292 1198676001256 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1198676001257 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1198676001258 nicotinate phosphoribosyltransferase; Validated; Region: PRK09243 1198676001259 Nicotinate phosphoribosyltransferase (NAPRTase), subgroup A. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting, reaction...; Region: NAPRTase_A; cd01570 1198676001260 active site 1198676001261 NAD synthase [Coenzyme metabolism]; Region: NadE; COG0171 1198676001262 NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553 1198676001263 homodimer interface [polypeptide binding]; other site 1198676001264 NAD binding pocket [chemical binding]; other site 1198676001265 ATP binding pocket [chemical binding]; other site 1198676001266 Mg binding site [ion binding]; other site 1198676001267 active-site loop [active] 1198676001268 Peptidase C1B subfamily (MEROPS database nomenclature); composed of eukaryotic bleomycin hydrolases (BH) and bacterial aminopeptidases C (pepC). The proteins of this subfamily contain a large insert relative to the C1A peptidase (papain) subfamily. BH is...; Region: Peptidase_C1B; cd00585 1198676001269 trimer interface [polypeptide binding]; other site 1198676001270 active site 1198676001271 G bulge; other site 1198676001272 Transglycosylase; Region: Transgly; pfam00912 1198676001273 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 1198676001274 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 1198676001275 Holliday junction-specific endonuclease; Reviewed; Region: recU; PRK02234 1198676001276 hypothetical protein; Provisional; Region: PRK13660 1198676001277 cell division protein GpsB; Provisional; Region: PRK14127 1198676001278 DivIVA domain; Region: DivI1A_domain; TIGR03544 1198676001279 Predicted N6-adenine-specific DNA methylase [DNA replication, recombination, and repair]; Region: COG0116 1198676001280 THUMP domain associated with S-adenosylmethionine-dependent methyltransferases; Region: THUMP_AdoMetMT; cd11715 1198676001281 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 1198676001282 S-ribosylhomocysteinase; Provisional; Region: PRK02260 1198676001283 hypothetical protein; Provisional; Region: PRK00106 1198676001284 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1198676001285 Zn2+ binding site [ion binding]; other site 1198676001286 Mg2+ binding site [ion binding]; other site 1198676001287 Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194 1198676001288 Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071 1198676001289 catalytic site [active] 1198676001290 G-X2-G-X-G-K; other site 1198676001291 DNA-directed RNA polymerase subunit omega; Reviewed; Region: rpoZ; PRK00392 1198676001292 Primosomal protein N' (replication factor Y) - superfamily II helicase [DNA replication, recombination, and repair]; Region: PriA; COG1198 1198676001293 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1198676001294 ATP binding site [chemical binding]; other site 1198676001295 putative Mg++ binding site [ion binding]; other site 1198676001296 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1198676001297 nucleotide binding region [chemical binding]; other site 1198676001298 ATP-binding site [chemical binding]; other site 1198676001299 methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005 1198676001300 Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646 1198676001301 putative active site [active] 1198676001302 substrate binding site [chemical binding]; other site 1198676001303 putative cosubstrate binding site; other site 1198676001304 catalytic site [active] 1198676001305 C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704 1198676001306 substrate binding site [chemical binding]; other site 1198676001307 16S rRNA methyltransferase B; Provisional; Region: PRK14902 1198676001308 NusB family; Region: NusB; pfam01029 1198676001309 putative RNA binding site [nucleotide binding]; other site 1198676001310 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1198676001311 S-adenosylmethionine binding site [chemical binding]; other site 1198676001312 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143 1198676001313 active site 1198676001314 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 1198676001315 Catalytic domain of Protein Kinases; Region: PKc; cd00180 1198676001316 active site 1198676001317 ATP binding site [chemical binding]; other site 1198676001318 substrate binding site [chemical binding]; other site 1198676001319 activation loop (A-loop); other site 1198676001320 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2815 1198676001321 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 1198676001322 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 1198676001323 PASTA domain; Region: PASTA; pfam03793 1198676001324 Predicted membrane protein [Function unknown]; Region: COG4758 1198676001325 Cell wall-active antibiotics response protein (DUF2154); Region: DUF2154; pfam09922 1198676001326 potential frameshift: common BLAST hit: gi|387786685|ref|YP_006251781.1| putative histidine kinase 1198676001327 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1198676001328 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1198676001329 active site 1198676001330 phosphorylation site [posttranslational modification] 1198676001331 intermolecular recognition site; other site 1198676001332 dimerization interface [polypeptide binding]; other site 1198676001333 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1198676001334 DNA binding residues [nucleotide binding] 1198676001335 dimerization interface [polypeptide binding]; other site 1198676001336 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1198676001337 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 1198676001338 active site 1198676001339 motif I; other site 1198676001340 motif II; other site 1198676001341 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 1198676001342 Peptidyl-prolyl cis-trans isomerase (rotamase) - cyclophilin family [Posttranslational modification, protein turnover, chaperones]; Region: PpiB; COG0652 1198676001343 active site 1198676001344 Predicted RNA binding protein (contains ribosomal protein S1 domain) [Translation, ribosomal structure and biogenesis]; Region: VacB; COG1098 1198676001345 hypothetical protein; Provisional; Region: PRK07252 1198676001346 RNA binding site [nucleotide binding]; other site 1198676001347 glycyl-radical enzyme activating protein family; Region: PFLE_PFLC; TIGR02494 1198676001348 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1198676001349 FeS/SAM binding site; other site 1198676001350 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 1198676001351 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 1198676001352 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 1198676001353 Pyruvate-formate lyase [Energy production and conversion]; Region: PflD; COG1882 1198676001354 Pyruvate formate lyase 2 and related enzymes; Region: PFL2_DhaB_BssA; cd01677 1198676001355 dimer interface [polypeptide binding]; other site 1198676001356 active site 1198676001357 glycine loop; other site 1198676001358 Transaldolase-like fructose-6-phosphate aldolases (FSA) found in bacteria and archaea; Region: Transaldolase_FSA; cd00956 1198676001359 active site 1198676001360 intersubunit interactions; other site 1198676001361 catalytic residue [active] 1198676001362 Glycerol dehydrogenase and related enzymes [Energy production and conversion]; Region: GldA; COG0371 1198676001363 Glycerol dehydrogenases (GlyDH) catalyzes oxidation of glycerol to dihydroxyacetone in glycerol dissmilation; Region: GlyDH; cd08170 1198676001364 dimer interface [polypeptide binding]; other site 1198676001365 active site 1198676001366 metal binding site [ion binding]; metal-binding site 1198676001367 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 1198676001368 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 1198676001369 dimer interface [polypeptide binding]; other site 1198676001370 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1198676001371 catalytic residue [active] 1198676001372 Uncharacterized conserved protein [Function unknown]; Region: COG1739 1198676001373 Uncharacterized protein family UPF0029; Region: UPF0029; pfam01205 1198676001374 Domain of unknown function (DUF1949); Region: DUF1949; pfam09186 1198676001375 Superfamily II DNA/RNA helicase required for DNA uptake (late competence protein) [DNA replication, recombination, and repair]; Region: comFA; COG4098 1198676001376 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1198676001377 ATP binding site [chemical binding]; other site 1198676001378 putative Mg++ binding site [ion binding]; other site 1198676001379 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1198676001380 nucleotide binding region [chemical binding]; other site 1198676001381 ATP-binding site [chemical binding]; other site 1198676001382 Predicted amidophosphoribosyltransferases [General function prediction only]; Region: ComFC; COG1040 1198676001383 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1198676001384 active site 1198676001385 RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552 1198676001386 30S subunit binding site; other site 1198676001387 Predicted membrane protein [Function unknown]; Region: COG4640 1198676001388 DNA adenine methylase (dam); Region: dam; TIGR00571 1198676001389 DNA modification methylase [DNA replication, recombination, and repair]; Region: COG0863 1198676001390 DNA methylase; Region: N6_N4_Mtase; pfam01555 1198676001391 DpnII restriction endonuclease; Region: DpnII; pfam04556 1198676001392 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 1198676001393 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 1198676001394 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 1198676001395 PRD domain; Region: PRD; pfam00874 1198676001396 PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568 1198676001397 active site 1198676001398 P-loop; other site 1198676001399 phosphorylation site [posttranslational modification] 1198676001400 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 1198676001401 active site 1198676001402 phosphorylation site [posttranslational modification] 1198676001403 PTS_IIB_ascorbate: subunit IIB of enzyme II (EII) of the L-ascorbate-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is an L-ascorbate-specific permease with two cytoplasmic subunits (IIA and IIB) and a...; Region: PTS_IIB_ascorbate; cd05563 1198676001404 active site 1198676001405 P-loop; other site 1198676001406 phosphorylation site [posttranslational modification] 1198676001407 PTS system ascorbate-specific transporter subunit IIC; Reviewed; Region: PRK12997 1198676001408 Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947 1198676001409 intersubunit interface [polypeptide binding]; other site 1198676001410 active site 1198676001411 zinc binding site [ion binding]; other site 1198676001412 Na+ binding site [ion binding]; other site 1198676001413 AAA domain; Region: AAA_33; pfam13671 1198676001414 Predicted O-methyltransferase [General function prediction only]; Region: COG4123 1198676001415 probable dihydroxyacetone kinase regulator; Region: DHAK_reg; TIGR02366 1198676001416 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1198676001417 myosin-cross-reactive antigen; Provisional; Region: PRK13977 1198676001418 Conserved hypothetical protein 95; Region: Cons_hypoth95; pfam03602 1198676001419 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1198676001420 S-adenosylmethionine binding site [chemical binding]; other site 1198676001421 phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168 1198676001422 Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163 1198676001423 active site 1198676001424 (T/H)XGH motif; other site 1198676001425 Predicted secreted protein containing a PDZ domain [Signal transduction mechanisms]; Region: SdrC; COG3480 1198676001426 PDZ domain, also called DHR (Dlg homologous region) or GLGF (after a conserved sequence motif). Many PDZ domains bind C-terminal polypeptides, though binding to internal (non-C-terminal) polypeptides and even to lipids has been demonstrated; Region: PDZ; cl00117 1198676001427 protein binding site [polypeptide binding]; other site 1198676001428 Escherichia coli UshA-like family, N-terminal metallophosphatase domain; Region: MPP_UshA_N_like; cd00845 1198676001429 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 1198676001430 active site 1198676001431 metal binding site [ion binding]; metal-binding site 1198676001432 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 1198676001433 Protein of unknown function (DUF1027); Region: DUF1027; pfam06265 1198676001434 ribosomal RNA large subunit methyltransferase N; Provisional; Region: PRK14455 1198676001435 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1198676001436 FeS/SAM binding site; other site 1198676001437 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1198676001438 putative multidrug transporter membrane\ATP-binding components; Provisional; Region: PRK10789 1198676001439 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1198676001440 Walker A/P-loop; other site 1198676001441 ATP binding site [chemical binding]; other site 1198676001442 Q-loop/lid; other site 1198676001443 ABC transporter signature motif; other site 1198676001444 Walker B; other site 1198676001445 D-loop; other site 1198676001446 H-loop/switch region; other site 1198676001447 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 1198676001448 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1198676001449 ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254 1198676001450 Walker A/P-loop; other site 1198676001451 ATP binding site [chemical binding]; other site 1198676001452 Q-loop/lid; other site 1198676001453 ABC transporter signature motif; other site 1198676001454 Walker B; other site 1198676001455 D-loop; other site 1198676001456 H-loop/switch region; other site 1198676001457 Helix-Turn-Helix DNA binding domain of the BmrR transcription regulator; Region: HTH_BmrR; cd01107 1198676001458 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 1198676001459 DNA binding residues [nucleotide binding] 1198676001460 drug binding residues [chemical binding]; other site 1198676001461 dimer interface [polypeptide binding]; other site 1198676001462 Uncharacterized conserved protein related to dihydrodipicolinate reductase [Function unknown]; Region: COG3804 1198676001463 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 1198676001464 Uncharacterized conserved protein [Function unknown]; Region: COG1359 1198676001465 Protein of unknown function (DUF975); Region: DUF975; pfam06161 1198676001466 Chorismate mutase type II; Region: CM_2; smart00830 1198676001467 anthranilate synthase component I; Provisional; Region: PRK13570 1198676001468 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 1198676001469 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 1198676001470 para-aminobenzoate synthase component II; Provisional; Region: PRK08857 1198676001471 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 1198676001472 glutamine binding [chemical binding]; other site 1198676001473 catalytic triad [active] 1198676001474 anthranilate phosphoribosyltransferase; Provisional; Region: trpD; PRK00188 1198676001475 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 1198676001476 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 1198676001477 Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331 1198676001478 active site 1198676001479 ribulose/triose binding site [chemical binding]; other site 1198676001480 phosphate binding site [ion binding]; other site 1198676001481 substrate (anthranilate) binding pocket [chemical binding]; other site 1198676001482 product (indole) binding pocket [chemical binding]; other site 1198676001483 Phosphoribosylanthranilate isomerase (PRAI) catalyzes the fourth step of the tryptophan biosynthesis, the conversion of N-(5'- phosphoribosyl)-anthranilate (PRA) to 1-(o-carboxyphenylamino)- 1-deoxyribulose 5-phosphate (CdRP). Most PRAIs are...; Region: PRAI; cd00405 1198676001484 active site 1198676001485 tryptophan synthase, beta subunit; Region: trpB; TIGR00263 1198676001486 Tryptophan synthase-beta: Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446 1198676001487 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1198676001488 catalytic residue [active] 1198676001489 Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724 1198676001490 tryptophan synthase alpha subunit; Provisional; Region: trpA; CHL00200 1198676001491 substrate binding site [chemical binding]; other site 1198676001492 active site 1198676001493 catalytic residues [active] 1198676001494 heterodimer interface [polypeptide binding]; other site 1198676001495 Type II secretory pathway, prepilin signal peptidase PulO and related peptidases [Cell motility and secretion / Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: PulO; COG1989 1198676001496 Bacterial Peptidase A24 N-terminal domain; Region: DiS_P_DiS; pfam06750 1198676001497 DNA-binding ferritin-like protein (oxidative damage protectant) [Inorganic ion transport and metabolism]; Region: Dps; COG0783 1198676001498 DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043 1198676001499 dimerization interface [polypeptide binding]; other site 1198676001500 DPS ferroxidase diiron center [ion binding]; other site 1198676001501 ion pore; other site 1198676001502 Bacterial protein of unknown function (DUF910); Region: DUF910; pfam06014 1198676001503 ROK family protein (putative glucokinase); Region: ROK_glcA_fam; TIGR00744 1198676001504 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 1198676001505 nucleotide binding site [chemical binding]; other site 1198676001506 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 1198676001507 active site residue [active] 1198676001508 Predicted membrane GTPase involved in stress response [Signal transduction mechanisms]; Region: TypA; COG1217 1198676001509 Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891 1198676001510 G1 box; other site 1198676001511 putative GEF interaction site [polypeptide binding]; other site 1198676001512 GTP/Mg2+ binding site [chemical binding]; other site 1198676001513 Switch I region; other site 1198676001514 G2 box; other site 1198676001515 G3 box; other site 1198676001516 Switch II region; other site 1198676001517 G4 box; other site 1198676001518 G5 box; other site 1198676001519 BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu. BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691 1198676001520 BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants. BipA is a highly...; Region: BipA_TypA_C; cd03710 1198676001521 Protein of unknown function (DUF3165); Region: DUF3165; pfam11364 1198676001522 UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK02472 1198676001523 Alanine dehydrogenase/PNT, C-terminal domain; Region: AlaDh_PNT_C; smart01002 1198676001524 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 1198676001525 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 1198676001526 undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726 1198676001527 MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785 1198676001528 active site 1198676001529 homodimer interface [polypeptide binding]; other site 1198676001530 POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478 1198676001531 Cell division protein FtsQ; Region: FtsQ; pfam03799 1198676001532 Cell division ATPase FtsA [Cell division and chromosome partitioning]; Region: ftsA; COG0849 1198676001533 Cell division protein FtsA; Region: FtsA; smart00842 1198676001534 Cell division protein FtsA; Region: FtsA; pfam14450 1198676001535 Domain of unknown function (DUF3484); Region: DUF3484; pfam11983 1198676001536 cell division protein FtsZ; Validated; Region: PRK09330 1198676001537 FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes. FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201 1198676001538 nucleotide binding site [chemical binding]; other site 1198676001539 SulA interaction site; other site 1198676001540 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, YBL036c-like proteins; Region: PLPDE_III_YBL036c_like; cd00635 1198676001541 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 1198676001542 catalytic residue [active] 1198676001543 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1799 1198676001544 YGGT family; Region: YGGT; pfam02325 1198676001545 Uncharacterized conserved protein, contains S4-like domain [Function unknown]; Region: COG2302 1198676001546 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1198676001547 RNA binding surface [nucleotide binding]; other site 1198676001548 DivIVA protein; Region: DivIVA; pfam05103 1198676001549 DivIVA domain; Region: DivI1A_domain; TIGR03544 1198676001550 isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK05743 1198676001551 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 1198676001552 active site 1198676001553 HIGH motif; other site 1198676001554 nucleotide binding site [chemical binding]; other site 1198676001555 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 1198676001556 active site 1198676001557 KMSKS motif; other site 1198676001558 Anticodon-binding domain of bacterial and eukaryotic mitochondrial isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_BEm; cd07960 1198676001559 tRNA binding surface [nucleotide binding]; other site 1198676001560 anticodon binding site; other site 1198676001561 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 1198676001562 Domain of unknown function (DUF1827); Region: DUF1827; pfam08860 1198676001563 Contains a crystal structure of the Nudix hydrolase from Enterococcus faecalis, which has an unknown function. In general, members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes...; Region: Nudix_Hydrolase_25; cd04684 1198676001564 nudix motif; other site 1198676001565 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1198676001566 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 1198676001567 Walker A motif; other site 1198676001568 ATP binding site [chemical binding]; other site 1198676001569 Walker B motif; other site 1198676001570 arginine finger; other site 1198676001571 UvrB/uvrC motif; Region: UVR; pfam02151 1198676001572 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1198676001573 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 1198676001574 Walker A motif; other site 1198676001575 ATP binding site [chemical binding]; other site 1198676001576 Walker B motif; other site 1198676001577 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 1198676001578 ornithine carbamoyltransferase; Validated; Region: PRK02102 1198676001579 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 1198676001580 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 1198676001581 Protein of unknown function (DUF1797); Region: DUF1797; cl11550 1198676001582 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 1198676001583 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1198676001584 dimer interface [polypeptide binding]; other site 1198676001585 conserved gate region; other site 1198676001586 putative PBP binding loops; other site 1198676001587 ABC-ATPase subunit interface; other site 1198676001588 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 1198676001589 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 1198676001590 Walker A/P-loop; other site 1198676001591 ATP binding site [chemical binding]; other site 1198676001592 Q-loop/lid; other site 1198676001593 ABC transporter signature motif; other site 1198676001594 Walker B; other site 1198676001595 D-loop; other site 1198676001596 H-loop/switch region; other site 1198676001597 FeoA domain; Region: FeoA; pfam04023 1198676001598 Fe2+ transport system protein A [Inorganic ion transport and metabolism]; Region: FeoA; COG1918 1198676001599 Fe2+ transport system protein B [Inorganic ion transport and metabolism]; Region: FeoB; COG0370 1198676001600 Ferrous iron transport protein B (FeoB) family; Region: FeoB; cd01879 1198676001601 G1 box; other site 1198676001602 GTP/Mg2+ binding site [chemical binding]; other site 1198676001603 Switch I region; other site 1198676001604 G2 box; other site 1198676001605 G3 box; other site 1198676001606 Switch II region; other site 1198676001607 G4 box; other site 1198676001608 G5 box; other site 1198676001609 Nucleoside recognition; Region: Gate; pfam07670 1198676001610 Ferrous iron transport protein B C terminus; Region: FeoB_C; pfam07664 1198676001611 Nucleoside recognition; Region: Gate; pfam07670 1198676001612 bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK14179 1198676001613 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763 1198676001614 NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080 1198676001615 homodimer interface [polypeptide binding]; other site 1198676001616 NADP binding site [chemical binding]; other site 1198676001617 substrate binding site [chemical binding]; other site 1198676001618 B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171 1198676001619 putative substrate binding site [chemical binding]; other site 1198676001620 putative ATP binding site [chemical binding]; other site 1198676001621 LrgB-like family; Region: LrgB; cl00596 1198676001622 LrgA family; Region: LrgA; cl00608 1198676001623 two-component response regulator; Provisional; Region: PRK14084 1198676001624 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1198676001625 active site 1198676001626 phosphorylation site [posttranslational modification] 1198676001627 intermolecular recognition site; other site 1198676001628 dimerization interface [polypeptide binding]; other site 1198676001629 LytTr DNA-binding domain; Region: LytTR; pfam04397 1198676001630 Putative regulator of cell autolysis [Signal transduction mechanisms]; Region: LytS; COG3275 1198676001631 5TMR of 5TMR-LYT; Region: 5TM-5TMR_LYT; pfam07694 1198676001632 GAF domain; Region: GAF_3; pfam13492 1198676001633 Histidine kinase; Region: His_kinase; pfam06580 1198676001634 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1198676001635 ATP binding site [chemical binding]; other site 1198676001636 Mg2+ binding site [ion binding]; other site 1198676001637 G-X-G motif; other site 1198676001638 exodeoxyribonuclease VII large subunit; Reviewed; Region: xseA; PRK00286 1198676001639 ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489 1198676001640 generic binding surface II; other site 1198676001641 generic binding surface I; other site 1198676001642 exodeoxyribonuclease VII small subunit; Provisional; Region: PRK00977 1198676001643 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 1198676001644 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 1198676001645 substrate binding pocket [chemical binding]; other site 1198676001646 chain length determination region; other site 1198676001647 substrate-Mg2+ binding site; other site 1198676001648 catalytic residues [active] 1198676001649 aspartate-rich region 1; other site 1198676001650 active site lid residues [active] 1198676001651 aspartate-rich region 2; other site 1198676001652 Predicted rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: COG1189 1198676001653 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1198676001654 RNA binding surface [nucleotide binding]; other site 1198676001655 FtsJ-like methyltransferase; Region: FtsJ; pfam01728 1198676001656 Arginine repressor [Transcription]; Region: ArgR; COG1438 1198676001657 Arginine repressor, DNA binding domain; Region: Arg_repressor; pfam01316 1198676001658 Arginine repressor, C-terminal domain; Region: Arg_repressor_C; pfam02863 1198676001659 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: RecN; COG0497 1198676001660 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 1198676001661 Walker A/P-loop; other site 1198676001662 ATP binding site [chemical binding]; other site 1198676001663 Q-loop/lid; other site 1198676001664 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 1198676001665 ABC transporter signature motif; other site 1198676001666 Walker B; other site 1198676001667 D-loop; other site 1198676001668 H-loop/switch region; other site 1198676001669 EDD domain protein, DegV family; Region: DegV; TIGR00762 1198676001670 Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645 1198676001671 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053 1198676001672 active site 1198676001673 catalytic triad [active] 1198676001674 oxyanion hole [active] 1198676001675 Uncharacterized protein conserved in bacteria (DUF2140); Region: DUF2140; pfam09911 1198676001676 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 1198676001677 IHF dimer interface [polypeptide binding]; other site 1198676001678 IHF - DNA interface [nucleotide binding]; other site 1198676001679 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1198676001680 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1198676001681 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 1198676001682 metal binding site 2 [ion binding]; metal-binding site 1198676001683 putative DNA binding helix; other site 1198676001684 metal binding site 1 [ion binding]; metal-binding site 1198676001685 dimer interface [polypeptide binding]; other site 1198676001686 structural Zn2+ binding site [ion binding]; other site 1198676001687 dihydroorotate dehydrogenase (subfamily 1) family protein; Region: pyrD_sub1_fam; TIGR01037 1198676001688 Dihydroorotate dehydrogenase (DHOD) class 1A FMN-binding domain. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine...; Region: DHOD_1A_like; cd04741 1198676001689 active site 1198676001690 FMN binding site [chemical binding]; other site 1198676001691 substrate binding site [chemical binding]; other site 1198676001692 catalytic residues [active] 1198676001693 homodimer interface [polypeptide binding]; other site 1198676001694 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1198676001695 catalytic core [active] 1198676001696 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1198676001697 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 1198676001698 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 1198676001699 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 1198676001700 recombination protein RecR; Reviewed; Region: recR; PRK00076 1198676001701 RecR protein; Region: RecR; pfam02132 1198676001702 TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR. RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025 1198676001703 putative active site [active] 1198676001704 putative metal-binding site [ion binding]; other site 1198676001705 tetramer interface [polypeptide binding]; other site 1198676001706 D-alanyl-alanine synthetase A; Reviewed; Region: ddl; PRK01966 1198676001707 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 1198676001708 D-ala D-ala ligase C-terminus; Region: Dala_Dala_lig_C; pfam07478 1198676001709 ECF-type riboflavin transporter, S component; Region: ECF-ribofla_trS; pfam07155 1198676001710 Predicted Na+-dependent transporter [General function prediction only]; Region: COG0385 1198676001711 Sodium Bile acid symporter family; Region: SBF; cl17470 1198676001712 UDP-N-acetylmuramyl pentapeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurF; COG0770 1198676001713 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 1198676001714 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 1198676001715 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 1198676001716 TIR domain; Region: TIR_2; pfam13676 1198676001717 Integral membrane protein (intg_mem_TP0381); Region: Intg_mem_TP0381; pfam09529 1198676001718 peptide chain release factor 3; Provisional; Region: prfC; PRK00741 1198676001719 Release Factor 3 (RF3) protein involved in the terminal step of translocation in bacteria; Region: RF3; cd04169 1198676001720 G1 box; other site 1198676001721 putative GEF interaction site [polypeptide binding]; other site 1198676001722 GTP/Mg2+ binding site [chemical binding]; other site 1198676001723 Switch I region; other site 1198676001724 G2 box; other site 1198676001725 G3 box; other site 1198676001726 Switch II region; other site 1198676001727 G4 box; other site 1198676001728 G5 box; other site 1198676001729 RF3_II: this subfamily represents the domain II of bacterial Release Factor 3 (RF3). Termination of protein synthesis by the ribosome requires two release factor (RF) classes. The class II RF3 is a GTPase that removes class I RFs (RF1 or RF2) from the...; Region: RF3_II; cd03689 1198676001730 Gram-positive signal peptide, YSIRK family; Region: YSIRK_signal; TIGR01168 1198676001731 Bacterial SH3 domain; Region: SH3_5; pfam08460 1198676001732 Bacterial SH3 domain; Region: SH3_5; pfam08460 1198676001733 GBS Bsp-like repeat; Region: GBS_Bsp-like; pfam08481 1198676001734 GBS Bsp-like repeat; Region: GBS_Bsp-like; pfam08481 1198676001735 GBS Bsp-like repeat; Region: GBS_Bsp-like; pfam08481 1198676001736 Bacterial SH3 domain; Region: SH3_5; pfam08460 1198676001737 putative cross-wall-targeting lipoprotein signal; Region: strep_RK_lipo; TIGR03726 1198676001738 Streptococcal surface antigen repeat; Region: Strep_SA_rep; pfam06696 1198676001739 Streptococcal surface antigen repeat; Region: Strep_SA_rep; pfam06696 1198676001740 Glucan-binding protein C; Region: GbpC; pfam08363 1198676001741 adhesin isopeptide-forming domain, sspB-C2 type; Region: isopep_sspB_C2; TIGR04228 1198676001742 Gram positive anchor; Region: Gram_pos_anchor; pfam00746 1198676001743 ATP-dependent RNA helicase SrmB; Provisional; Region: PRK11192 1198676001744 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 1198676001745 ATP binding site [chemical binding]; other site 1198676001746 Mg++ binding site [ion binding]; other site 1198676001747 motif III; other site 1198676001748 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1198676001749 nucleotide binding region [chemical binding]; other site 1198676001750 ATP-binding site [chemical binding]; other site 1198676001751 Predicted O-methyltransferase [General function prediction only]; Region: COG4123 1198676001752 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1198676001753 S-adenosylmethionine binding site [chemical binding]; other site 1198676001754 The GIY-YIG domain of uncharacterized protein family UPF0213 related to structure-specific endonuclease SLX1; Region: GIY-YIG_UPF0213; cd10456 1198676001755 GIY-YIG motif/motif A; other site 1198676001756 putative active site [active] 1198676001757 putative metal binding site [ion binding]; other site 1198676001758 Protein of unknown function with HXXEE motif; Region: HXXEE; pfam13787 1198676001759 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 1198676001760 Catalytic NodB homology domain of Streptococcus mutans polysaccharide deacetylase PgdA, Bacillus subtilis YheN, and similar proteins; Region: CE4_SmPgdA_like; cd10944 1198676001761 NodB motif; other site 1198676001762 active site 1198676001763 catalytic site [active] 1198676001764 Zn binding site [ion binding]; other site 1198676001765 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 1198676001766 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 1198676001767 putative acyl-acceptor binding pocket; other site 1198676001768 SLBB domain; Region: SLBB; pfam10531 1198676001769 comEA protein; Region: comE; TIGR01259 1198676001770 Helix-hairpin-helix motif; Region: HHH; pfam00633 1198676001771 Predicted membrane metal-binding protein [General function prediction only]; Region: ComEC; COG0658 1198676001772 Domain of unknown function (DUF4131); Region: DUF4131; pfam13567 1198676001773 Telomere length regulation protein; Region: Telomere_reg-2; pfam10193 1198676001774 Competence protein; Region: Competence; pfam03772 1198676001775 Predicted hydrolase (metallo-beta-lactamase superfamily) [General function prediction only]; Region: ComEC; COG2333 1198676001776 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 1198676001777 Protein of unknown function (DUF805); Region: DUF805; cl01224 1198676001778 DNA polymerase III subunit delta; Reviewed; Region: holA; PRK05574 1198676001779 DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144 1198676001780 Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605 1198676001781 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 1198676001782 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 1198676001783 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 1198676001784 Putative membrane peptidase family (DUF2324); Region: DUF2324; pfam10086 1198676001785 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1198676001786 MarR family; Region: MarR_2; pfam12802 1198676001787 Acyl-CoA thioester hydrolase/BAAT N-terminal region; Region: Bile_Hydr_Trans; pfam04775 1198676001788 Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412 1198676001789 BAAT / Acyl-CoA thioester hydrolase C terminal; Region: BAAT_C; pfam08840 1198676001790 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Provisional; Region: queA; PRK00147 1198676001791 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Region: queA; TIGR00113 1198676001792 Nodulin-21 and CCC1-related protein family; Region: Nodulin-21_like_1; cd02432 1198676001793 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363 1198676001794 GlcN6P_deaminase: Glucosamine-6-phosphate (GlcN6P) deaminase subfamily; GlcN6P deaminase catalyzes the reversible conversion of GlcN6P to D-fructose-6-phosphate (Fru6P) and ammonium. The reaction is an aldo-keto isomerization coupled with an amination or...; Region: GlcN6P_deaminase; cd01399 1198676001795 active site 1198676001796 trimer interface [polypeptide binding]; other site 1198676001797 allosteric site; other site 1198676001798 active site lid [active] 1198676001799 hexamer (dimer of trimers) interface [polypeptide binding]; other site 1198676001800 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 1198676001801 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1198676001802 RNA binding surface [nucleotide binding]; other site 1198676001803 Pseudouridine synthase, Escherichia coli RsuA like; Region: PseudoU_synth_RsuA; cd02553 1198676001804 active site 1198676001805 uracil binding [chemical binding]; other site 1198676001806 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1198676001807 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 1198676001808 Coenzyme A binding pocket [chemical binding]; other site 1198676001809 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 1198676001810 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1198676001811 DNA-binding site [nucleotide binding]; DNA binding site 1198676001812 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1198676001813 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1198676001814 homodimer interface [polypeptide binding]; other site 1198676001815 catalytic residue [active] 1198676001816 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 1198676001817 Zeta-crystallin with NADP-dependent quinone reductase activity (QOR); Region: zeta_crystallin; cd08253 1198676001818 NAD(P) binding site [chemical binding]; other site 1198676001819 Esterase/lipase [Lipid metabolism]; Region: Aes; COG0657 1198676001820 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 1198676001821 Competence protein CoiA-like family; Region: CoiA; pfam06054 1198676001822 Oligoendopeptidase F [Amino acid transport and metabolism]; Region: COG1164 1198676001823 Peptidase family M3B Oligopeptidase F (PepF); Region: M3B_PepF_3; cd09608 1198676001824 active site 1198676001825 Zn binding site [ion binding]; other site 1198676001826 Haloacid dehalogenase-like hydrolase; Region: HAD_2; pfam13419 1198676001827 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1198676001828 motif II; other site 1198676001829 Predicted O-methyltransferase [General function prediction only]; Region: COG4122 1198676001830 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1198676001831 S-adenosylmethionine binding site [chemical binding]; other site 1198676001832 foldase protein PrsA; Reviewed; Region: prsA; PRK01326 1198676001833 SurA N-terminal domain; Region: SurA_N; pfam09312 1198676001834 PPIC-type PPIASE domain; Region: Rotamase_2; pfam13145 1198676001835 Tubby C 2; Region: Tub_2; cl02043 1198676001836 alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252 1198676001837 Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673 1198676001838 motif 1; other site 1198676001839 active site 1198676001840 motif 2; other site 1198676001841 motif 3; other site 1198676001842 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 1198676001843 DHHA1 domain; Region: DHHA1; pfam02272 1198676001844 NMT1-like family; Region: NMT1_2; pfam13379 1198676001845 NMT1/THI5 like; Region: NMT1; pfam09084 1198676001846 substrate binding pocket [chemical binding]; other site 1198676001847 membrane-bound complex binding site; other site 1198676001848 hinge residues; other site 1198676001849 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 1198676001850 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 1198676001851 Walker A/P-loop; other site 1198676001852 ATP binding site [chemical binding]; other site 1198676001853 Q-loop/lid; other site 1198676001854 ABC transporter signature motif; other site 1198676001855 Walker B; other site 1198676001856 D-loop; other site 1198676001857 H-loop/switch region; other site 1198676001858 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 1198676001859 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1198676001860 dimer interface [polypeptide binding]; other site 1198676001861 conserved gate region; other site 1198676001862 putative PBP binding loops; other site 1198676001863 ABC-ATPase subunit interface; other site 1198676001864 gallidermin-class lantibiotic protection ABC transporter, ATP-binding subunit; Region: galliderm_ABC; TIGR03740 1198676001865 ATP-binding cassette domain of the bacitracin-resistance transporter; Region: ABC_BcrA_bacitracin_resist; cd03268 1198676001866 Walker A/P-loop; other site 1198676001867 ATP binding site [chemical binding]; other site 1198676001868 Q-loop/lid; other site 1198676001869 ABC transporter signature motif; other site 1198676001870 Walker B; other site 1198676001871 D-loop; other site 1198676001872 H-loop/switch region; other site 1198676001873 lantibiotic protection ABC transporter permease subunit, MutE/EpiE family; Region: lanti_perm_MutE; TIGR03732 1198676001874 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 1198676001875 lantibiotic protection ABC transporter permease subunit, MutG family; Region: lanti_perm_MutG; TIGR03733 1198676001876 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 1198676001877 TraX protein; Region: TraX; cl05434 1198676001878 proteobacterial dedicated sortase system response regulator; Region: marine_sort_RR; TIGR03787 1198676001879 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1198676001880 active site 1198676001881 phosphorylation site [posttranslational modification] 1198676001882 intermolecular recognition site; other site 1198676001883 dimerization interface [polypeptide binding]; other site 1198676001884 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1198676001885 DNA binding site [nucleotide binding] 1198676001886 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1198676001887 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 1198676001888 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1198676001889 dimer interface [polypeptide binding]; other site 1198676001890 phosphorylation site [posttranslational modification] 1198676001891 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1198676001892 ATP binding site [chemical binding]; other site 1198676001893 Mg2+ binding site [ion binding]; other site 1198676001894 G-X-G motif; other site 1198676001895 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1198676001896 non-specific DNA binding site [nucleotide binding]; other site 1198676001897 salt bridge; other site 1198676001898 sequence-specific DNA binding site [nucleotide binding]; other site 1198676001899 CAAX protease self-immunity; Region: Abi; pfam02517 1198676001900 N-acetyl-gamma-glutamyl-phosphate reductase; Validated; Region: argC; PRK00436 1198676001901 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 1198676001902 Ornithine acetyltransferase (OAT) family; also referred to as ArgJ. OAT catalyzes the first and fifth steps in arginine biosynthesis, coupling acetylation of glutamate with deacetylation of N-acetylornithine, which allows recycling of the acetyl group in...; Region: OAT; cd02152 1198676001903 heterotetramer interface [polypeptide binding]; other site 1198676001904 active site pocket [active] 1198676001905 cleavage site 1198676001906 AAK_NAGK-like: N-Acetyl-L-glutamate kinase (NAGK)-like . Included in this CD are the Escherichia coli and Pseudomonas aeruginosa type NAGKs which catalyze the phosphorylation of N-acetyl-L-glutamate (NAG) by ATP in the second step of arginine...; Region: AAK_NAGK-like; cd04238 1198676001907 nucleotide binding site [chemical binding]; other site 1198676001908 N-acetyl-L-glutamate binding site [chemical binding]; other site 1198676001909 acetylornithine aminotransferase; Provisional; Region: PRK04260 1198676001910 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 1198676001911 inhibitor-cofactor binding pocket; inhibition site 1198676001912 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1198676001913 catalytic residue [active] 1198676001914 ribonucleotide-diphosphate reductase subunit beta; Provisional; Region: nrdF2; PRK13966 1198676001915 Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049 1198676001916 dimer interface [polypeptide binding]; other site 1198676001917 putative radical transfer pathway; other site 1198676001918 diiron center [ion binding]; other site 1198676001919 tyrosyl radical; other site 1198676001920 ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK07306 1198676001921 Ribonucleotide reductase N-terminal; Region: RNR_N; pfam08343 1198676001922 Class I ribonucleotide reductase; Region: RNR_I; cd01679 1198676001923 active site 1198676001924 dimer interface [polypeptide binding]; other site 1198676001925 catalytic residues [active] 1198676001926 effector binding site; other site 1198676001927 R2 peptide binding site; other site 1198676001928 NrdH-redoxin (NrdH) family; NrdH is a small monomeric protein with a conserved redox active CXXC motif within a TRX fold, characterized by a glutaredoxin (GRX)-like sequence and TRX-like activity profile. In vitro, it displays protein disulfide reductase...; Region: NrdH; cd02976 1198676001929 catalytic residues [active] 1198676001930 aconitate hydratase; Validated; Region: PRK09277 1198676001931 Aconitase A catalytic domain; Region: AcnA_IRP; cd01586 1198676001932 substrate binding site [chemical binding]; other site 1198676001933 ligand binding site [chemical binding]; other site 1198676001934 Aconitase A swivel domain. This is the major form of the TCA cycle enzyme aconitate hydratase, also known as aconitase and citrate hydro-lyase. It includes bacterial and archaeal aconitase A, and the eukaryotic cytosolic form of aconitase. This group...; Region: AcnA_IRP_Swivel; cd01580 1198676001935 substrate binding site [chemical binding]; other site 1198676001936 Bacillus subtilis (Bs) citrate synthase (CS)-II_like. CS catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the citric acid cycle (TCA or Krebs cycle). 2MCS catalyzes the...; Region: BSuCS-II_like; cd06110 1198676001937 dimer interface [polypeptide binding]; other site 1198676001938 Citrate synthase; Region: Citrate_synt; pfam00285 1198676001939 active site 1198676001940 citrylCoA binding site [chemical binding]; other site 1198676001941 oxalacetate/citrate binding site [chemical binding]; other site 1198676001942 coenzyme A binding site [chemical binding]; other site 1198676001943 catalytic triad [active] 1198676001944 Isocitrate/isopropylmalate dehydrogenase; Region: Iso_dh; cl00445 1198676001945 isocitrate dehydrogenase; Validated; Region: PRK06451 1198676001946 Predicted membrane protein [Function unknown]; Region: COG4905 1198676001947 Protein of unknown function (DUF1113); Region: DUF1113; pfam06541 1198676001948 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 1198676001949 dimerization domain swap beta strand [polypeptide binding]; other site 1198676001950 regulatory protein interface [polypeptide binding]; other site 1198676001951 active site 1198676001952 regulatory phosphorylation site [posttranslational modification]; other site 1198676001953 Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism]; Region: PtsA; COG1080 1198676001954 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 1198676001955 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 1198676001956 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 1198676001957 NADP+-dependent non-phosphorylating glyceraldehyde 3-phosphate dehydrogenase and ALDH family 11; Region: ALDH_F11_NP-GAPDH; cd07082 1198676001958 NADP-dependent glyceraldehyde-3-phosphate dehydrogenase; Provisional; Region: PLN00412 1198676001959 tetrameric interface [polypeptide binding]; other site 1198676001960 activator binding site; other site 1198676001961 NADP binding site [chemical binding]; other site 1198676001962 substrate binding site [chemical binding]; other site 1198676001963 catalytic residues [active] 1198676001964 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 1198676001965 Helix-Turn-Helix DNA binding domain of the MerR-like transcription regulators YyaN and YraB; Region: HTH_YyaN; cd01109 1198676001966 DNA binding residues [nucleotide binding] 1198676001967 putative dimer interface [polypeptide binding]; other site 1198676001968 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1198676001969 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1198676001970 active site 1198676001971 catalytic tetrad [active] 1198676001972 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1198676001973 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1198676001974 active site 1198676001975 catalytic tetrad [active] 1198676001976 Uncharacterized homolog of gamma-carboxymuconolactone decarboxylase subunit [Function unknown]; Region: COG0599 1198676001977 Macro domain, a high-affinity ADP-ribose binding module found in a variety of proteins as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly ADP-ribose polymerases). Some macro domains recognize poly...; Region: Macro; cl00019 1198676001978 Dynamin family; Region: Dynamin_N; pfam00350 1198676001979 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 1198676001980 G1 box; other site 1198676001981 GTP/Mg2+ binding site [chemical binding]; other site 1198676001982 G2 box; other site 1198676001983 Switch I region; other site 1198676001984 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cd00882 1198676001985 G2 box; other site 1198676001986 Switch I region; other site 1198676001987 G3 box; other site 1198676001988 Switch II region; other site 1198676001989 GTP/Mg2+ binding site [chemical binding]; other site 1198676001990 G4 box; other site 1198676001991 G5 box; other site 1198676001992 Domain of unknown function DUF87; Region: DUF87; pfam01935 1198676001993 AAA-like domain; Region: AAA_10; pfam12846 1198676001994 A nuclease of the HNH/ENDO VII superfamily with conserved LHH; Region: LHH; pfam14411 1198676001995 SMI1 / KNR4 family; Region: SMI1_KNR4; smart00860 1198676001996 Flagellin N-methylase; Region: FliB; pfam03692 1198676001997 GBS Bsp-like repeat; Region: GBS_Bsp-like; pfam08481 1198676001998 GBS Bsp-like repeat; Region: GBS_Bsp-like; pfam08481 1198676001999 GBS Bsp-like repeat; Region: GBS_Bsp-like; pfam08481 1198676002000 GBS Bsp-like repeat; Region: GBS_Bsp-like; pfam08481 1198676002001 GBS Bsp-like repeat; Region: GBS_Bsp-like; pfam08481 1198676002002 GBS Bsp-like repeat; Region: GBS_Bsp-like; pfam08481 1198676002003 AtlA is an autolysin found in Gram-positive lactic acid bacteria that degrades bacterial cell walls by catalyzing the hydrolysis of 1,4-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues. This family includes the AtlA and Aml...; Region: GH25_AtlA-like; cd06522 1198676002004 Glycosyl hydrolases family 25; Region: Glyco_hydro_25; pfam01183 1198676002005 active site 1198676002006 peptidase T; Region: peptidase-T; TIGR01882 1198676002007 M20 Peptidase T specifically cleaves tripeptides; Region: M20_peptT; cd03892 1198676002008 metal binding site [ion binding]; metal-binding site 1198676002009 dimer interface [polypeptide binding]; other site 1198676002010 Ferredoxin [Energy production and conversion]; Region: Fer; COG1141 1198676002011 cytidylate kinase; Provisional; Region: cmk; PRK00023 1198676002012 Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190 1198676002013 active site 1198676002014 Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020 1198676002015 CMP-binding site; other site 1198676002016 The sites determining sugar specificity; other site 1198676002017 translation initiation factor IF-3; Reviewed; Region: infC; PRK00028 1198676002018 Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198 1198676002019 Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707 1198676002020 50S ribosomal protein L35; Reviewed; Region: rpmI; PRK00172 1198676002021 Ribosomal protein L20; Region: Ribosomal_L20; cd07026 1198676002022 23S rRNA binding site [nucleotide binding]; other site 1198676002023 L21 binding site [polypeptide binding]; other site 1198676002024 L13 binding site [polypeptide binding]; other site 1198676002025 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1198676002026 catalytic core [active] 1198676002027 hypothetical protein; Provisional; Region: PRK11770 1198676002028 Domain of unknown function (DUF307); Region: DUF307; pfam03733 1198676002029 Domain of unknown function (DUF307); Region: DUF307; pfam03733 1198676002030 This CD includes cysteinyl-tRNA(Pro) deacylases from Haemophilus influenzae and Escherichia coli and other related bacterial proteins. These trans-acting, single-domain proteins are homologs of ProX and also the cis-acting prolyl-tRNA synthetase (ProRS)...; Region: YbaK_deacylase; cd00002 1198676002031 putative deacylase active site [active] 1198676002032 Predicted membrane protein [Function unknown]; Region: COG2035 1198676002033 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 1198676002034 amidase catalytic site [active] 1198676002035 Zn binding residues [ion binding]; other site 1198676002036 substrate binding site [chemical binding]; other site 1198676002037 Thiamine transporter protein (Thia_YuaJ); Region: Thia_YuaJ; pfam09515 1198676002038 PlyB is a bacteriophage endolysin that displays potent lytic activity toward Bacillus anthracis. PlyB has an N-terminal glycosyl hydrolase family 25 (GH25) catalytic domain and a C-terminal bacterial SH3-like domain, SH3b. Both domains are required for...; Region: GH25_PlyB-like; cd06523 1198676002039 Glycosyl hydrolases family 25; Region: Glyco_hydro_25; pfam01183 1198676002040 active site 1198676002041 Inner membrane protein CreD; Region: CreD; cl01844 1198676002042 phosphoenolpyruvate carboxylase; Reviewed; Region: PRK00009 1198676002043 Phosphoenolpyruvate carboxylase [Energy production and conversion]; Region: Ppc; COG2352 1198676002044 Bacterial cell division membrane protein [Cell division and chromosome partitioning]; Region: FtsW; COG0772 1198676002045 elongation factor Tu; Reviewed; Region: PRK00049 1198676002046 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 1198676002047 G1 box; other site 1198676002048 GEF interaction site [polypeptide binding]; other site 1198676002049 GTP/Mg2+ binding site [chemical binding]; other site 1198676002050 Switch I region; other site 1198676002051 G2 box; other site 1198676002052 G3 box; other site 1198676002053 Switch II region; other site 1198676002054 G4 box; other site 1198676002055 G5 box; other site 1198676002056 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 1198676002057 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 1198676002058 Antibiotic Binding Site [chemical binding]; other site 1198676002059 Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311 1198676002060 triosephosphate isomerase; Provisional; Region: PRK14565 1198676002061 substrate binding site [chemical binding]; other site 1198676002062 dimer interface [polypeptide binding]; other site 1198676002063 catalytic triad [active] 1198676002064 FemAB family; Region: FemAB; pfam02388 1198676002065 FemAB family; Region: FemAB; pfam02388 1198676002066 sugar phosphate phosphatase; Provisional; Region: PRK10513 1198676002067 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1198676002068 active site 1198676002069 motif I; other site 1198676002070 motif II; other site 1198676002071 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1198676002072 HD superfamily phosphohydrolases [General function prediction only]; Region: COG1078 1198676002073 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1198676002074 Zn2+ binding site [ion binding]; other site 1198676002075 Mg2+ binding site [ion binding]; other site 1198676002076 Domain of unknown function (DUF1934); Region: DUF1934; pfam09148 1198676002077 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; smart00831 1198676002078 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 1198676002079 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 1198676002080 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 1198676002081 haloacid dehalogenase-like hydrolase; Region: HAD; pfam12710 1198676002082 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 1198676002083 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 1198676002084 Glycerophosphodiester phosphodiesterase domain of Thermoanaerobacter tengcongensis and similar proteins; Region: GDPD_TtGDE_like; cd08563 1198676002085 active site 1198676002086 catalytic site [active] 1198676002087 metal binding site [ion binding]; metal-binding site 1198676002088 dimer interface [polypeptide binding]; other site 1198676002089 Predicted phosphohydrolases [General function prediction only]; Region: Icc; COG1409 1198676002090 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cd00838 1198676002091 active site 1198676002092 metal binding site [ion binding]; metal-binding site 1198676002093 Helix-Turn-Helix DNA binding domain of putative transcription regulators from the MerR superfamily; Region: HTH_MerR-like_sg3; cd01282 1198676002094 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 1198676002095 DNA binding residues [nucleotide binding] 1198676002096 putative dimer interface [polypeptide binding]; other site 1198676002097 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 1198676002098 alcohol dehydrogenase and quinone reductase-like medium chain degydrogenases/reductases; Region: MDR_like_2; cd05289 1198676002099 putative NAD(P) binding site [chemical binding]; other site 1198676002100 Regulators of stationary/sporulation gene expression [Transcription]; Region: AbrB; COG2002 1198676002101 looped-hinge helix DNA binding domain, AbrB family; Region: lp_hng_hel_AbrB; TIGR01439 1198676002102 gallidermin-class lantibiotic protection ABC transporter, ATP-binding subunit; Region: galliderm_ABC; TIGR03740 1198676002103 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 1198676002104 Walker A/P-loop; other site 1198676002105 ATP binding site [chemical binding]; other site 1198676002106 Q-loop/lid; other site 1198676002107 ABC transporter signature motif; other site 1198676002108 Walker B; other site 1198676002109 D-loop; other site 1198676002110 H-loop/switch region; other site 1198676002111 ABC-2 family transporter protein; Region: ABC2_membrane_5; pfam13346 1198676002112 looped-hinge helix DNA binding domain, AbrB family; Region: lp_hng_hel_AbrB; TIGR01439 1198676002113 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1198676002114 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 1198676002115 Protein of unknown function (DUF3114); Region: DUF3114; pfam11311 1198676002116 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1198676002117 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 1198676002118 active site 1198676002119 motif I; other site 1198676002120 motif II; other site 1198676002121 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 1198676002122 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1198676002123 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 1198676002124 active site 1198676002125 motif I; other site 1198676002126 motif II; other site 1198676002127 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1198676002128 signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416 1198676002129 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 1198676002130 P loop; other site 1198676002131 GTP binding site [chemical binding]; other site 1198676002132 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1198676002133 putative substrate translocation pore; other site 1198676002134 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1198676002135 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1198676002136 Predicted membrane protein [Function unknown]; Region: COG3689 1198676002137 Predicted permeases [General function prediction only]; Region: COG0701 1198676002138 Transcriptional accessory protein [Transcription]; Region: Tex; COG2183 1198676002139 Tex-like protein N-terminal domain; Region: Tex_N; pfam09371 1198676002140 Likely ribonuclease with RNase H fold; Region: YqgFc; smart00732 1198676002141 S1_Tex: The C-terminal S1 domain of a transcription accessory factor called Tex, which has been characterized in Bordetella pertussis and Pseudomonas aeruginosa. The tex gene is essential in Bortella pertusis and is named for its role in toxin expression; Region: S1_Tex; cd05685 1198676002142 RNA binding site [nucleotide binding]; other site 1198676002143 hypothetical protein; Provisional; Region: PRK04351 1198676002144 SprT homologues; Region: SprT; cl01182 1198676002145 PspC domain; Region: PspC; pfam04024 1198676002146 HPr kinase/phosphorylase; Provisional; Region: PRK05428 1198676002147 HPr Serine kinase N terminus; Region: Hpr_kinase_N; pfam02603 1198676002148 HprK/P, the bifunctional histidine-containing protein kinase/phosphatase, controls the phosphorylation state of the phosphocarrier protein HPr and regulates the utilization of carbon sources by gram-positive bacteria. It catalyzes both the ATP-dependent...; Region: HprK_C; cd01918 1198676002149 Hpr binding site; other site 1198676002150 active site 1198676002151 homohexamer subunit interaction site [polypeptide binding]; other site 1198676002152 prolipoprotein diacylglyceryl transferase; Reviewed; Region: PRK12437 1198676002153 Uncharacterized protein containing a divergent version of the methyl-accepting chemotaxis-like domain [General function prediction only]; Region: COG4768 1198676002154 YtxH-like protein; Region: YtxH; pfam12732 1198676002155 Protein of unknown function (DUF3270); Region: DUF3270; pfam11674 1198676002156 Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826 1198676002157 Peptidase family U32; Region: Peptidase_U32; pfam01136 1198676002158 Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826 1198676002159 Peptidase family U32; Region: Peptidase_U32; pfam01136 1198676002160 peroxiredoxin; Region: AhpC; TIGR03137 1198676002161 Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015 1198676002162 dimer interface [polypeptide binding]; other site 1198676002163 decamer (pentamer of dimers) interface [polypeptide binding]; other site 1198676002164 catalytic triad [active] 1198676002165 peroxidatic and resolving cysteines [active] 1198676002166 alkyl hydroperoxide reductase subunit F; Provisional; Region: PRK15317 1198676002167 Alkyl hydroperoxide reductase F subunit (AhpF) N-terminal domain (NTD) family, N-terminal TRX-fold subdomain; AhpF is a homodimeric flavoenzyme which catalyzes the NADH-dependent reduction of the peroxiredoxin AhpC, which in turn catalyzes the reduction...; Region: AhpF_NTD_N; cd02974 1198676002168 catalytic residue [active] 1198676002169 TRX-GRX-like family, Alkyl hydroperoxide reductase F subunit (AhpF) N-terminal domain (NTD) subfamily, C-terminal TRX-fold subdomain; AhpF is a homodimeric flavoenzyme which catalyzes the NADH-dependent reduction of the peroxiredoxin AhpC, which then...; Region: AhpF_NTD_C; cd03026 1198676002170 catalytic residues [active] 1198676002171 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1198676002172 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1198676002173 Uncharacterized protein conserved in bacteria (DUF2128); Region: DUF2128; pfam09901 1198676002174 manganese transport protein MntH; Reviewed; Region: PRK00701 1198676002175 Natural resistance-associated macrophage protein; Region: Nramp; pfam01566 1198676002176 Gram-positive signal peptide, YSIRK family; Region: YSIRK_signal; TIGR01168 1198676002177 glucan-binding repeat; Region: glucan_65_rpt; TIGR04035 1198676002178 Putative cell wall binding repeat; Region: CW_binding_1; pfam01473 1198676002179 glucan-binding repeat; Region: glucan_65_rpt; TIGR04035 1198676002180 Predicted peptidase [General function prediction only]; Region: COG4099 1198676002181 lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484 1198676002182 LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322 1198676002183 dimer interface [polypeptide binding]; other site 1198676002184 putative anticodon binding site; other site 1198676002185 Lys_tRNA synthetase (LysRS) class II core domain. Class II LysRS is a dimer which attaches a lysine to the 3' OH group of ribose of the appropriate tRNA. Its assignment to class II aaRS is based upon its structure and the presence of three...; Region: LysRS_core; cd00775 1198676002186 motif 1; other site 1198676002187 active site 1198676002188 motif 2; other site 1198676002189 motif 3; other site 1198676002190 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1198676002191 Predicted hydrolase (HAD superfamily) [General function prediction only]; Region: COG1011 1198676002192 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1198676002193 motif II; other site 1198676002194 Phosphoglycerol transferase and related proteins, alkaline phosphatase superfamily [Cell envelope biogenesis, outer membrane]; Region: MdoB; COG1368 1198676002195 Sulfatase; Region: Sulfatase; pfam00884 1198676002196 Predicted SAM-dependent methyltransferases [General function prediction only]; Region: COG1092 1198676002197 Middle domain of the SAM-dependent methyltransferase RlmI and related proteins; Region: RlmI_M_like; cd11572 1198676002198 putative RNA binding site [nucleotide binding]; other site 1198676002199 Methyltransferase domain; Region: Methyltransf_26; pfam13659 1198676002200 3-dehydroquinate dehydratase [Amino acid transport and metabolism]; Region: AroD; COG0710 1198676002201 Type I 3-dehydroquinase, (3-dehydroquinate dehydratase or DHQase); Region: DHQase_I; cd00502 1198676002202 active site 1198676002203 catalytic residue [active] 1198676002204 dimer interface [polypeptide binding]; other site 1198676002205 shikimate 5-dehydrogenase; Reviewed; Region: aroE; PRK00258 1198676002206 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 1198676002207 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 1198676002208 NAD(P) binding site [chemical binding]; other site 1198676002209 shikimate binding site; other site 1198676002210 Glycerol dehydrogenase and related enzymes [Energy production and conversion]; Region: GldA; COG0371 1198676002211 Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195 1198676002212 active site 1198676002213 dimer interface [polypeptide binding]; other site 1198676002214 metal binding site [ion binding]; metal-binding site 1198676002215 Chorismate synthase [Amino acid transport and metabolism]; Region: AroC; COG0082 1198676002216 Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304 1198676002217 Tetramer interface [polypeptide binding]; other site 1198676002218 active site 1198676002219 FMN-binding site [chemical binding]; other site 1198676002220 prephenate dehydrogenase; Validated; Region: PRK06545 1198676002221 prephenate dehydrogenase; Validated; Region: PRK08507 1198676002222 C-terminal ACT domain of the monofunctional, NAD dependent, prephenate dehydrogenase (PDH); Region: ACT_PDH-BS; cd04909 1198676002223 hypothetical protein; Provisional; Region: PRK13676 1198676002224 3-phosphoshikimate 1-carboxyvinyltransferase; Provisional; Region: PRK02427 1198676002225 EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556 1198676002226 hinge; other site 1198676002227 active site 1198676002228 shikimate kinase; Reviewed; Region: aroK; PRK00131 1198676002229 Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464 1198676002230 ADP binding site [chemical binding]; other site 1198676002231 magnesium binding site [ion binding]; other site 1198676002232 putative shikimate binding site; other site 1198676002233 prephenate dehydratase; Provisional; Region: PRK11898 1198676002234 Prephenate dehydratase; Region: PDT; pfam00800 1198676002235 C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905 1198676002236 putative L-Phe binding site [chemical binding]; other site 1198676002237 Transcriptional regulator [Transcription]; Region: LytR; COG1316 1198676002238 SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase [Translation, ribosomal structure and biogenesis]; Region: TrmA; COG2265 1198676002239 Predicted RNA-binding protein, contains TRAM domain [General function prediction only]; Region: COG3269 1198676002240 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1198676002241 S-adenosylmethionine binding site [chemical binding]; other site 1198676002242 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1198676002243 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1198676002244 LysR substrate binding domain; Region: LysR_substrate; pfam03466 1198676002245 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1198676002246 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1198676002247 putative substrate translocation pore; other site 1198676002248 SnoaL-like domain; Region: SnoaL_4; pfam13577 1198676002249 SnoaL-like domain; Region: SnoaL_3; pfam13474 1198676002250 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1198676002251 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1198676002252 active site 1198676002253 catalytic tetrad [active] 1198676002254 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1198676002255 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1198676002256 GyrI-like small molecule binding domain; Region: GyrI-like; cl01368 1198676002257 CAAX protease self-immunity; Region: Abi; pfam02517 1198676002258 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 1198676002259 CoenzymeA binding site [chemical binding]; other site 1198676002260 subunit interaction site [polypeptide binding]; other site 1198676002261 PHB binding site; other site 1198676002262 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 1198676002263 active site 1198676002264 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629 1198676002265 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 1198676002266 triphenylmethane reductase (TMR)-like proteins, NMRa-like, atypical (a) SDRs; Region: TMR_SDR_a; cd05269 1198676002267 NADP binding site [chemical binding]; other site 1198676002268 Predicted thioesterase [General function prediction only]; Region: COG5496 1198676002269 GTPase CgtA; Reviewed; Region: obgE; PRK12297 1198676002270 GTP1/OBG; Region: GTP1_OBG; pfam01018 1198676002271 Obg GTPase; Region: Obg; cd01898 1198676002272 G1 box; other site 1198676002273 GTP/Mg2+ binding site [chemical binding]; other site 1198676002274 Switch I region; other site 1198676002275 G2 box; other site 1198676002276 G3 box; other site 1198676002277 Switch II region; other site 1198676002278 G4 box; other site 1198676002279 G5 box; other site 1198676002280 Domain of unknown function (DUF1967); Region: DUF1967; pfam09269 1198676002281 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 1198676002282 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1198676002283 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1198676002284 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 1198676002285 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 1198676002286 Walker A/P-loop; other site 1198676002287 ATP binding site [chemical binding]; other site 1198676002288 Q-loop/lid; other site 1198676002289 ABC transporter signature motif; other site 1198676002290 Walker B; other site 1198676002291 D-loop; other site 1198676002292 H-loop/switch region; other site 1198676002293 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 1198676002294 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1198676002295 substrate binding pocket [chemical binding]; other site 1198676002296 membrane-bound complex binding site; other site 1198676002297 hinge residues; other site 1198676002298 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1198676002299 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 1198676002300 substrate binding pocket [chemical binding]; other site 1198676002301 membrane-bound complex binding site; other site 1198676002302 hinge residues; other site 1198676002303 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1198676002304 dimer interface [polypeptide binding]; other site 1198676002305 conserved gate region; other site 1198676002306 putative PBP binding loops; other site 1198676002307 ABC-ATPase subunit interface; other site 1198676002308 excinuclease ABC subunit B; Provisional; Region: PRK05298 1198676002309 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1198676002310 ATP binding site [chemical binding]; other site 1198676002311 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1198676002312 nucleotide binding region [chemical binding]; other site 1198676002313 ATP-binding site [chemical binding]; other site 1198676002314 Ultra-violet resistance protein B; Region: UvrB; pfam12344 1198676002315 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1198676002316 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1198676002317 non-specific DNA binding site [nucleotide binding]; other site 1198676002318 salt bridge; other site 1198676002319 sequence-specific DNA binding site [nucleotide binding]; other site 1198676002320 MutT homolog-1 (MTH1) is a member of the Nudix hydrolase superfamily. MTH1, the mammalian counterpart of MutT, hydrolyzes oxidized purine nucleoside triphosphates, such as 8-oxo-dGTP and 2-hydroxy-ATP, to monophosphates, thereby preventing the...; Region: MTH1; cd03427 1198676002321 putative active site [active] 1198676002322 nucleotide binding site [chemical binding]; other site 1198676002323 nudix motif; other site 1198676002324 putative metal binding site [ion binding]; other site 1198676002325 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 1198676002326 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1198676002327 substrate binding pocket [chemical binding]; other site 1198676002328 membrane-bound complex binding site; other site 1198676002329 hinge residues; other site 1198676002330 transaminase; Validated; Region: PRK07324 1198676002331 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1198676002332 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1198676002333 homodimer interface [polypeptide binding]; other site 1198676002334 catalytic residue [active] 1198676002335 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 1198676002336 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1198676002337 substrate binding pocket [chemical binding]; other site 1198676002338 membrane-bound complex binding site; other site 1198676002339 hinge residues; other site 1198676002340 30S ribosomal protein S21; Reviewed; Region: rpsU; PRK00270 1198676002341 large-conductance mechanosensitive channel; Reviewed; Region: mscL; PRK00567 1198676002342 Large-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscL; COG1970 1198676002343 DNA primase; Validated; Region: dnaG; PRK05667 1198676002344 DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275 1198676002345 TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364 1198676002346 active site 1198676002347 metal binding site [ion binding]; metal-binding site 1198676002348 interdomain interaction site; other site 1198676002349 RNA polymerase sigma factor RpoD; Validated; Region: PRK09210 1198676002350 Sigma-70 factor, region 1.1; Region: Sigma70_r1_1; pfam03979 1198676002351 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 1198676002352 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1198676002353 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 1198676002354 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1198676002355 DNA binding residues [nucleotide binding] 1198676002356 Predicted metal-sulfur cluster biosynthetic enzyme [General function prediction only]; Region: PaaD; COG2151 1198676002357 dTDP-6-deoxy-L-lyxo-4-hexulose reductase and related proteins, extended (e) SDRs; Region: dTDP_HR_like_SDR_e; cd05254 1198676002358 RmlD substrate binding domain; Region: RmlD_sub_bind; pfam04321 1198676002359 NADP binding site [chemical binding]; other site 1198676002360 active site 1198676002361 putative substrate binding site [chemical binding]; other site 1198676002362 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1198676002363 This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_6; cd04955 1198676002364 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 1198676002365 Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_d; cd04196 1198676002366 Probable Catalytic site; other site 1198676002367 ABC-type polysaccharide/polyol phosphate export systems, permease component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagG; COG1682 1198676002368 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 1198676002369 ABC-type polysaccharide/polyol phosphate transport system, ATPase component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagH; COG1134 1198676002370 ATP-binding cassette component of polysaccharide transport system; Region: ABC_KpsT_Wzt; cd03220 1198676002371 Walker A/P-loop; other site 1198676002372 ATP binding site [chemical binding]; other site 1198676002373 Q-loop/lid; other site 1198676002374 ABC transporter signature motif; other site 1198676002375 Walker B; other site 1198676002376 D-loop; other site 1198676002377 H-loop/switch region; other site 1198676002378 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 1198676002379 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 1198676002380 active site 1198676002381 Rhamnan synthesis protein F; Region: RgpF; pfam05045 1198676002382 Sulfatase; Region: Sulfatase; pfam00884 1198676002383 undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714 1198676002384 Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187 1198676002385 Ligand binding site; other site 1198676002386 Putative Catalytic site; other site 1198676002387 DXD motif; other site 1198676002388 glycosyltransferase, TIGR04182 family; Region: glyco_TIGR04182 1198676002389 DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179 1198676002390 Ligand binding site; other site 1198676002391 Putative Catalytic site; other site 1198676002392 DXD motif; other site 1198676002393 GBS Bsp-like repeat; Region: GBS_Bsp-like; pfam08481 1198676002394 GBS Bsp-like repeat; Region: GBS_Bsp-like; pfam08481 1198676002395 GBS Bsp-like repeat; Region: GBS_Bsp-like; pfam08481 1198676002396 GBS Bsp-like repeat; Region: GBS_Bsp-like; pfam08481 1198676002397 Surface antigen [General function prediction only]; Region: COG3942 1198676002398 CHAP domain; Region: CHAP; pfam05257 1198676002399 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1198676002400 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1198676002401 active site 1198676002402 catalytic tetrad [active] 1198676002403 glutathione reductase; Validated; Region: PRK06116 1198676002404 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1198676002405 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1198676002406 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 1198676002407 folylpolyglutamate synthase/dihydrofolate synthase; Region: folC; TIGR01499 1198676002408 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 1198676002409 Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104 1198676002410 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 1198676002411 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1198676002412 catalytic residue [active] 1198676002413 thiamine biosynthesis protein ThiI; Provisional; Region: PRK01565 1198676002414 THUMP domain of thiamine biosynthesis protein ThiI; Region: THUMP_ThiI; cd11716 1198676002415 ThiI is required for thiazole synthesis in the thiamine biosynthesis pathway. It belongs to the Adenosine Nucleotide Hydrolysis suoerfamily and predicted to bind to Adenosine nucleotide; Region: ThiI; cd01712 1198676002416 Ligand Binding Site [chemical binding]; other site 1198676002417 Bacterial capsule synthesis protein PGA_cap; Region: PGA_cap; smart00854 1198676002418 CapA and related proteins, metallophosphatase domain; Region: MPP_CapA; cd07381 1198676002419 putative active site [active] 1198676002420 putative metal binding site [ion binding]; other site 1198676002421 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1198676002422 Coenzyme A binding pocket [chemical binding]; other site 1198676002423 Protein of unknown function (DUF1211); Region: DUF1211; pfam06736 1198676002424 50S ribosomal protein L21; Validated; Region: rplU; PRK05573 1198676002425 Protein of unknown function (DUF464); Region: DUF464; pfam04327 1198676002426 50S ribosomal protein L27; Validated; Region: rpmA; PRK05435 1198676002427 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 1198676002428 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 1198676002429 NADH pyrophosphatase, a member of the Nudix hydrolase superfamily, catalyzes the cleavage of NADH into reduced nicotinamide mononucleotide (NMNH) and AMP. Like other members of the Nudix family, it requires a divalent cation, such as Mg2+ or Mn2+, for...; Region: NADH_pyrophosphatase; cd03429 1198676002430 putative NADH binding site [chemical binding]; other site 1198676002431 putative active site [active] 1198676002432 nudix motif; other site 1198676002433 putative metal binding site [ion binding]; other site 1198676002434 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1198676002435 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1198676002436 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 1198676002437 dimerization interface [polypeptide binding]; other site 1198676002438 Signal peptidase (SPase) II; Region: Peptidase_A8; cl00458 1198676002439 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 1198676002440 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1198676002441 RNA binding surface [nucleotide binding]; other site 1198676002442 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 1198676002443 active site 1198676002444 Uncharacterized conserved protein [Function unknown]; Region: COG0398 1198676002445 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 1198676002446 Pyrimidine operon attenuation protein/uracil phosphoribosyltransferase [Nucleotide transport and metabolism]; Region: PyrR; COG2065 1198676002447 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1198676002448 active site 1198676002449 uracil transporter; Provisional; Region: PRK10720 1198676002450 aspartate carbamoyltransferase catalytic subunit; Provisional; Region: pyrB; PRK00856 1198676002451 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 1198676002452 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 1198676002453 carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564 1198676002454 Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; smart01097 1198676002455 Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744 1198676002456 catalytic site [active] 1198676002457 subunit interface [polypeptide binding]; other site 1198676002458 carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294 1198676002459 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 1198676002460 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 1198676002461 Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787 1198676002462 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 1198676002463 ATP-grasp domain; Region: ATP-grasp_4; cl17255 1198676002464 Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424 1198676002465 IMP binding site; other site 1198676002466 dimer interface [polypeptide binding]; other site 1198676002467 interdomain contacts; other site 1198676002468 partial ornithine binding site; other site 1198676002469 Membrane-fusion protein [Cell envelope biogenesis, outer membrane]; Region: AcrA; COG0845 1198676002470 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 1198676002471 HlyD family secretion protein; Region: HlyD_3; pfam13437 1198676002472 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 1198676002473 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 1198676002474 Walker A/P-loop; other site 1198676002475 ATP binding site [chemical binding]; other site 1198676002476 Q-loop/lid; other site 1198676002477 ABC transporter signature motif; other site 1198676002478 Walker B; other site 1198676002479 D-loop; other site 1198676002480 H-loop/switch region; other site 1198676002481 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 1198676002482 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 1198676002483 FtsX-like permease family; Region: FtsX; pfam02687 1198676002484 Ribosomal protein S16 [Translation, ribosomal structure and biogenesis]; Region: RpsP; COG0228 1198676002485 Predicted RNA-binding protein (contains KH domain) [General function prediction only]; Region: COG1837 1198676002486 KH domain; Region: KH_4; pfam13083 1198676002487 16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK00122 1198676002488 RimM N-terminal domain; Region: RimM; pfam01782 1198676002489 PRC-barrel domain; Region: PRC; pfam05239 1198676002490 tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026 1198676002491 Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492 1198676002492 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1198676002493 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 1198676002494 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 1198676002495 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 1198676002496 Fructose-1-phosphate kinase and related fructose-6-phosphate kinase (PfkB) [Carbohydrate transport and metabolism]; Region: FruK; COG1105 1198676002497 1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164 1198676002498 putative substrate binding site [chemical binding]; other site 1198676002499 putative ATP binding site [chemical binding]; other site 1198676002500 PTS system 2-O-a-mannosyl-D-glycerate specific transporter subunit IIABC; Provisional; Region: PRK09765 1198676002501 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 1198676002502 active site 1198676002503 phosphorylation site [posttranslational modification] 1198676002504 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569 1198676002505 active site 1198676002506 P-loop; other site 1198676002507 phosphorylation site [posttranslational modification] 1198676002508 Phosphotransferase system, fructose-specific IIC component [Carbohydrate transport and metabolism]; Region: FruA; COG1299 1198676002509 5-methyltetrahydropteroyltriglutamate--homocysteine S-methyltransferase; Provisional; Region: PRK05222 1198676002510 CIMS - Cobalamine-independent methonine synthase, or MetE, N-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_N_terminal_like; cd03312 1198676002511 THF binding site; other site 1198676002512 CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311 1198676002513 substrate binding site [chemical binding]; other site 1198676002514 THF binding site; other site 1198676002515 zinc-binding site [ion binding]; other site 1198676002516 bifunctional homocysteine S-methyltransferase/5,10-methylenetetrahydrofolate reductase protein; Reviewed; Region: PRK08645 1198676002517 Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; cl14105 1198676002518 Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cd00537 1198676002519 FAD binding site [chemical binding]; other site 1198676002520 Integrase core domain; Region: rve; pfam00665 1198676002521 Integrase core domain; Region: rve_3; pfam13683 1198676002522 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 1198676002523 Transposase; Region: HTH_Tnp_1; cl17663 1198676002524 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 1198676002525 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 1198676002526 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1198676002527 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1198676002528 Alpha-galactosidase [Carbohydrate transport and metabolism]; Region: GalA; COG3345 1198676002529 Melibiase; Region: Melibiase; pfam02065 1198676002530 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 1198676002531 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 1198676002532 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1198676002533 dimer interface [polypeptide binding]; other site 1198676002534 conserved gate region; other site 1198676002535 putative PBP binding loops; other site 1198676002536 ABC-ATPase subunit interface; other site 1198676002537 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 1198676002538 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1198676002539 dimer interface [polypeptide binding]; other site 1198676002540 conserved gate region; other site 1198676002541 putative PBP binding loops; other site 1198676002542 ABC-ATPase subunit interface; other site 1198676002543 Alpha amylase catalytic domain found in sucrose phosphorylase (also called sucrose glucosyltransferase, disaccharide glucosyltransferase, and sucrose-phosphate alpha-D glucosyltransferase); Region: AmyAc_Sucrose_phosphorylase; cd11355 1198676002544 sucrose phosphorylase; Region: sucrose_gtfA; TIGR03852 1198676002545 active site 1198676002546 homodimer interface [polypeptide binding]; other site 1198676002547 catalytic site [active] 1198676002548 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 1198676002549 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 1198676002550 Walker A/P-loop; other site 1198676002551 ATP binding site [chemical binding]; other site 1198676002552 Q-loop/lid; other site 1198676002553 ABC transporter signature motif; other site 1198676002554 Walker B; other site 1198676002555 D-loop; other site 1198676002556 H-loop/switch region; other site 1198676002557 TOBE domain; Region: TOBE_2; pfam08402 1198676002558 alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403 1198676002559 Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333 1198676002560 Ca binding site [ion binding]; other site 1198676002561 active site 1198676002562 catalytic site [active] 1198676002563 DNA-binding transcriptional repressor EbgR; Provisional; Region: PRK10339 1198676002564 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1198676002565 DNA binding site [nucleotide binding] 1198676002566 Ligand-binding domain of DNA transcription repressor GalR which is one of two regulatory proteins involved in galactose transport and metabolism; Region: PBP1_GalR; cd01544 1198676002567 putative dimerization interface [polypeptide binding]; other site 1198676002568 putative ligand binding site [chemical binding]; other site 1198676002569 galactokinase; Provisional; Region: PRK05322 1198676002570 Galactokinase galactose-binding signature; Region: GalKase_gal_bdg; pfam10509 1198676002571 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 1198676002572 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 1198676002573 galactose-1-phosphate uridylyltransferase; Provisional; Region: PRK05270 1198676002574 Galactose-1-phosphate uridyl transferase, N-terminal domain; Region: GalP_UDP_transf; pfam01087 1198676002575 Galactose-1-phosphate uridyl transferase, C-terminal domain; Region: GalP_UDP_tr_C; pfam02744 1198676002576 UDP-glucose 4-epimerase [Cell envelope biogenesis, outer membrane]; Region: GalE; COG1087 1198676002577 UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247 1198676002578 NAD binding site [chemical binding]; other site 1198676002579 homodimer interface [polypeptide binding]; other site 1198676002580 active site 1198676002581 substrate binding site [chemical binding]; other site 1198676002582 Beta-lactamase; Region: Beta-lactamase; pfam00144 1198676002583 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 1198676002584 PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cd01610 1198676002585 active site 1198676002586 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1198676002587 ABC transporter signature motif; other site 1198676002588 Walker B; other site 1198676002589 D-loop; other site 1198676002590 H-loop/switch region; other site 1198676002591 Protein of unknown function (DUF1149); Region: DUF1149; pfam06619 1198676002592 EDD domain protein, DegV family; Region: DegV; TIGR00762 1198676002593 Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645 1198676002594 dihydrodipicolinate reductase; Provisional; Region: PRK00048 1198676002595 Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113 1198676002596 Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173 1198676002597 tRNA CCA-pyrophosphorylase; Provisional; Region: PRK13299 1198676002598 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 1198676002599 active site 1198676002600 NTP binding site [chemical binding]; other site 1198676002601 metal binding triad [ion binding]; metal-binding site 1198676002602 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 1198676002603 tRNA nucleotidyltransferase domain 2 putative; Region: tRNA_NucTran2_2; pfam13735 1198676002604 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 1198676002605 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1198676002606 Walker A/P-loop; other site 1198676002607 ATP binding site [chemical binding]; other site 1198676002608 Q-loop/lid; other site 1198676002609 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1198676002610 ABC transporter; Region: ABC_tran_2; pfam12848 1198676002611 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1198676002612 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 1198676002613 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1198676002614 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1198676002615 Walker A/P-loop; other site 1198676002616 ATP binding site [chemical binding]; other site 1198676002617 Q-loop/lid; other site 1198676002618 ABC transporter signature motif; other site 1198676002619 Walker B; other site 1198676002620 D-loop; other site 1198676002621 H-loop/switch region; other site 1198676002622 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 1198676002623 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1198676002624 ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254 1198676002625 Walker A/P-loop; other site 1198676002626 ATP binding site [chemical binding]; other site 1198676002627 Q-loop/lid; other site 1198676002628 ABC transporter signature motif; other site 1198676002629 Walker B; other site 1198676002630 D-loop; other site 1198676002631 H-loop/switch region; other site 1198676002632 Membrane transport protein; Region: Mem_trans; cl09117 1198676002633 KxYKxGKxW signal peptide; Region: KxYKxGKxW; TIGR03715 1198676002634 Glycosyl hydrolase family 70; Region: Glyco_hydro_70; pfam02324 1198676002635 Alpha amylase catalytic domain family; Region: AmyAc_family; cl07893 1198676002636 Alpha amylase catalytic domain family; Region: AmyAc_family; cl07893 1198676002637 glucan-binding repeat; Region: glucan_65_rpt; TIGR04035 1198676002638 glucan-binding repeat; Region: glucan_65_rpt; TIGR04035 1198676002639 glucan-binding repeat; Region: glucan_65_rpt; TIGR04035 1198676002640 glucan-binding repeat; Region: glucan_65_rpt; TIGR04035 1198676002641 glucan-binding repeat; Region: glucan_65_rpt; TIGR04035 1198676002642 glutamate dehydrogenase; Provisional; Region: PRK09414 1198676002643 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 1198676002644 NAD(P) binding domain of glutamate dehydrogenase, subgroup 2; Region: NAD_bind_2_Glu_DH; cd05313 1198676002645 NAD(P) binding site [chemical binding]; other site 1198676002646 Protein of unknown function (DUF3021); Region: DUF3021; pfam11457 1198676002647 7-cyano-7-deazaguanine reductase; Provisional; Region: PRK13258 1198676002648 7-cyano-7-deazaguanosine (preQ0) biosynthesis protein QueE; Region: Bsubt_queE; TIGR03365 1198676002649 putative 7-cyano-7-deazaguanosine (preQ0) biosynthesis protein QueE; Region: rSAM_QueE_Ecoli; TIGR04322 1198676002650 6-pyruvoyl tetrahydropterin synthase; Region: PTPS; pfam01242 1198676002651 active site 1198676002652 ExsB is a transcription regulator related protein. It is a subfamily of a Adenosine nucleotide binding superfamily of proteins. This protein family is represented by a single member in nearly every completed large (> 1000 genes) prokaryotic genome. In...; Region: ExsB; cd01995 1198676002653 Ligand Binding Site [chemical binding]; other site 1198676002654 Transcriptional regulators [Transcription]; Region: MarR; COG1846 1198676002655 MarR family; Region: MarR_2; pfam12802 1198676002656 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 1198676002657 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1198676002658 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1198676002659 Walker A/P-loop; other site 1198676002660 ATP binding site [chemical binding]; other site 1198676002661 Q-loop/lid; other site 1198676002662 ABC transporter signature motif; other site 1198676002663 Walker B; other site 1198676002664 D-loop; other site 1198676002665 H-loop/switch region; other site 1198676002666 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 1198676002667 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1198676002668 ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254 1198676002669 Walker A/P-loop; other site 1198676002670 ATP binding site [chemical binding]; other site 1198676002671 Q-loop/lid; other site 1198676002672 ABC transporter signature motif; other site 1198676002673 Walker B; other site 1198676002674 D-loop; other site 1198676002675 H-loop/switch region; other site 1198676002676 Peroxiredoxin (PRX) family, Atypical 2-cys PRX subfamily; composed of PRXs containing peroxidatic and resolving cysteines, similar to the homodimeric thiol specific antioxidant (TSA) protein also known as TRX-dependent thiol peroxidase (Tpx). Tpx is a...; Region: PRX_Atyp2cys; cd03014 1198676002677 dimer interface [polypeptide binding]; other site 1198676002678 catalytic triad [active] 1198676002679 peroxidatic and resolving cysteines [active] 1198676002680 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 1198676002681 synthetase active site [active] 1198676002682 NTP binding site [chemical binding]; other site 1198676002683 metal binding site [ion binding]; metal-binding site 1198676002684 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1198676002685 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1198676002686 active site 1198676002687 phosphorylation site [posttranslational modification] 1198676002688 intermolecular recognition site; other site 1198676002689 dimerization interface [polypeptide binding]; other site 1198676002690 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1198676002691 DNA binding site [nucleotide binding] 1198676002692 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1198676002693 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1198676002694 dimer interface [polypeptide binding]; other site 1198676002695 phosphorylation site [posttranslational modification] 1198676002696 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1198676002697 ATP binding site [chemical binding]; other site 1198676002698 Mg2+ binding site [ion binding]; other site 1198676002699 G-X-G motif; other site 1198676002700 Protein of unknown function (DUF1304); Region: DUF1304; cl01533 1198676002701 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1198676002702 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1198676002703 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 1198676002704 dimerization interface [polypeptide binding]; other site 1198676002705 The URO-D _like protein superfamily includes bacterial and eukaryotic uroporphyrinogen decarboxylases (URO-D), coenzyme M methyltransferases and other putative bacterial methyltransferases. Uroporphyrinogen decarboxylase (URO-D) decarboxylates the four...; Region: URO-D_like; cd03465 1198676002706 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 1198676002707 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1198676002708 substrate binding pocket [chemical binding]; other site 1198676002709 membrane-bound complex binding site; other site 1198676002710 hinge residues; other site 1198676002711 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1198676002712 dimer interface [polypeptide binding]; other site 1198676002713 conserved gate region; other site 1198676002714 putative PBP binding loops; other site 1198676002715 ABC-ATPase subunit interface; other site 1198676002716 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 1198676002717 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1198676002718 dimer interface [polypeptide binding]; other site 1198676002719 conserved gate region; other site 1198676002720 putative PBP binding loops; other site 1198676002721 ABC-ATPase subunit interface; other site 1198676002722 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 1198676002723 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 1198676002724 Walker A/P-loop; other site 1198676002725 ATP binding site [chemical binding]; other site 1198676002726 Q-loop/lid; other site 1198676002727 ABC transporter signature motif; other site 1198676002728 Walker B; other site 1198676002729 D-loop; other site 1198676002730 H-loop/switch region; other site 1198676002731 diphosphomevalonate decarboxylase; Region: PLN02407 1198676002732 diphosphomevalonate decarboxylase; Region: mevDPdecarb; TIGR01240 1198676002733 Mevalonate kinase [Lipid metabolism]; Region: ERG12; COG1577 1198676002734 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 1198676002735 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 1198676002736 isopentenyl pyrophosphate isomerase; Provisional; Region: PRK05437 1198676002737 Isopentenyl-diphosphate:dimethylallyl diphosphate isomerase type 2 (IDI-2) FMN-binding domain. Two types of IDIs have been characterized at present. The long known IDI-1 is only dependent on divalent metals for activity, whereas IDI-2 requires a metal; Region: IDI-2_FMN; cd02811 1198676002738 homotetramer interface [polypeptide binding]; other site 1198676002739 FMN binding site [chemical binding]; other site 1198676002740 homodimer contacts [polypeptide binding]; other site 1198676002741 putative active site [active] 1198676002742 putative substrate binding site [chemical binding]; other site 1198676002743 Predicted membrane protein, hemolysin III homolog [General function prediction only]; Region: COG1272 1198676002744 channel protein, hemolysin III family; Region: hlyIII; TIGR01065 1198676002745 Domain of unknown function (DUF1836); Region: DUF1836; pfam08876 1198676002746 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 1198676002747 Class II hydroxymethylglutaryl-coenzyme A (HMG-CoA) reductase (HMGR); Region: HMG-CoA_reductase_classII; cd00644 1198676002748 homodimer interface [polypeptide binding]; other site 1198676002749 catalytic residues [active] 1198676002750 NAD binding site [chemical binding]; other site 1198676002751 substrate binding pocket [chemical binding]; other site 1198676002752 flexible flap; other site 1198676002753 3-hydroxy-3-methylglutaryl CoA synthase, prokaryotic clade; Region: HMG-CoA-S_prok; TIGR01835 1198676002754 "initiating" condensing enzymes are a subclass of decarboxylating condensing enzymes, including beta-ketoacyl [ACP] synthase, type III and polyketide synthases, type III, which include chalcone synthase and related enzymes. They are...; Region: init_cond_enzymes; cd00827 1198676002755 dimer interface [polypeptide binding]; other site 1198676002756 active site 1198676002757 thymidylate synthase; Reviewed; Region: thyA; PRK01827 1198676002758 Thymidylate synthase and pyrimidine hydroxymethylase: Thymidylate synthase (TS) and deoxycytidylate hydroxymethylase (dCMP-HMase) are homologs that catalyze analogous alkylation of C5 of pyrimidine nucleotides. Both enzymes are involved in the...; Region: TS_Pyrimidine_HMase; cd00351 1198676002759 dimerization interface [polypeptide binding]; other site 1198676002760 active site 1198676002761 Nicotinamide mononucleotide transporter; Region: NMN_transporter; pfam04973 1198676002762 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 1198676002763 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cd00209 1198676002764 folate binding site [chemical binding]; other site 1198676002765 NADP+ binding site [chemical binding]; other site 1198676002766 ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342 1198676002767 ClpX C4-type zinc finger; Region: zf-C4_ClpX; pfam06689 1198676002768 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1198676002769 Walker A motif; other site 1198676002770 ATP binding site [chemical binding]; other site 1198676002771 Walker B motif; other site 1198676002772 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 1198676002773 YihA (EngB) GTPase family; Region: YihA_EngB; cd01876 1198676002774 G1 box; other site 1198676002775 GTP/Mg2+ binding site [chemical binding]; other site 1198676002776 Switch I region; other site 1198676002777 G2 box; other site 1198676002778 G3 box; other site 1198676002779 Switch II region; other site 1198676002780 G4 box; other site 1198676002781 G5 box; other site 1198676002782 S-methylmethionine transporter; Provisional; Region: PRK11387 1198676002783 homocysteine methyltransferase; Provisional; Region: mmuM; PRK09485 1198676002784 Homocysteine S-methyltransferase; Region: S-methyl_trans; pfam02574 1198676002785 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 1198676002786 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1198676002787 DNA-binding site [nucleotide binding]; DNA binding site 1198676002788 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1198676002789 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1198676002790 Pyridoxal kinase plays a key role in the synthesis of the active coenzyme pyridoxal-5'-phosphate (PLP), by catalyzing the phosphorylation of the precursor vitamin B6 in the presence of Zn2+ and ATP. Mammals are unable to synthesize PLP de novo and...; Region: pyridoxal_pyridoxamine_kinase; cd01173 1198676002791 dimer interface [polypeptide binding]; other site 1198676002792 pyridoxal binding site [chemical binding]; other site 1198676002793 ATP binding site [chemical binding]; other site 1198676002794 Predicted membrane protein [Function unknown]; Region: COG4720 1198676002795 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1198676002796 ATPases of the AAA+ class [Posttranslational modification, protein turnover, chaperones]; Region: SpoVK; COG0464 1198676002797 Walker A motif; other site 1198676002798 ATP binding site [chemical binding]; other site 1198676002799 Walker B motif; other site 1198676002800 arginine finger; other site 1198676002801 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1198676002802 Walker A motif; other site 1198676002803 ATP binding site [chemical binding]; other site 1198676002804 Walker B motif; other site 1198676002805 arginine finger; other site 1198676002806 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 1198676002807 Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797 1198676002808 23S rRNA interface [nucleotide binding]; other site 1198676002809 Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site 1198676002810 Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387 1198676002811 core dimer interface [polypeptide binding]; other site 1198676002812 L10 interface [polypeptide binding]; other site 1198676002813 L11 interface [polypeptide binding]; other site 1198676002814 putative EF-Tu interaction site [polypeptide binding]; other site 1198676002815 putative EF-G interaction site [polypeptide binding]; other site 1198676002816 Uncharacterized conserved protein [Function unknown]; Region: COG2128 1198676002817 Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627 1198676002818 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1198676002819 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1198676002820 active site 1198676002821 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 1198676002822 Putative catalytic NodB homology domain of PgaB, IcaB, and similar proteins which consist of a deformed (beta/alpha)8 barrel fold with 5- or 6-strands; Region: CE4_NodB_like_5s_6s; cd10918 1198676002823 putative active site [active] 1198676002824 putative metal binding site [ion binding]; other site 1198676002825 homoserine dehydrogenase; Provisional; Region: PRK06349 1198676002826 Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447 1198676002827 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 1198676002828 ACT_HSDH_Hom CD includes the C-terminal ACT domain of the NAD(P)H-dependent, homoserine dehydrogenase (HSDH) and related domains; Region: ACT_HSDH-Hom; cd04881 1198676002829 homoserine kinase; Provisional; Region: PRK01212 1198676002830 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 1198676002831 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 1198676002832 Folylpolyglutamate synthase [Coenzyme metabolism]; Region: FolC; COG0285 1198676002833 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 1198676002834 GTP cyclohydrolase I (GTP-CH-I) catalyzes the conversion of GTP into dihydroneopterin triphosphate. The enzyme product is the precursor of tetrahydrofolate in eubacteria, fungi, and plants and of the folate analogs in methanogenic bacteria. In...; Region: GTP_cyclohydro1; cd00642 1198676002835 homodecamer interface [polypeptide binding]; other site 1198676002836 GTP cyclohydrolase I; Provisional; Region: PLN03044 1198676002837 active site 1198676002838 putative catalytic site residues [active] 1198676002839 zinc binding site [ion binding]; other site 1198676002840 GTP-CH-I/GFRP interaction surface; other site 1198676002841 potential frameshift: common BLAST hit: gi|387786241|ref|YP_006251337.1| dihydropteroate synthase 1198676002842 Dihydroneopterin aldolase (DHNA) and 7,8-dihydroneopterin triphosphate epimerase domain (DHNTPE); these enzymes have been designated folB and folX, respectively. Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and...; Region: DHNA_DHNTPE; cd00534 1198676002843 homooctamer interface [polypeptide binding]; other site 1198676002844 active site 1198676002845 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483 1198676002846 catalytic center binding site [active] 1198676002847 ATP binding site [chemical binding]; other site 1198676002848 UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK13905 1198676002849 FAD binding domain; Region: FAD_binding_4; pfam01565 1198676002850 UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873 1198676002851 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 1198676002852 ATP-binding cassette domain of the polyamine transporter; Region: ABC_PotA_N; cd03300 1198676002853 Walker A/P-loop; other site 1198676002854 ATP binding site [chemical binding]; other site 1198676002855 Q-loop/lid; other site 1198676002856 ABC transporter signature motif; other site 1198676002857 Walker B; other site 1198676002858 D-loop; other site 1198676002859 H-loop/switch region; other site 1198676002860 TOBE domain; Region: TOBE_2; pfam08402 1198676002861 sulfate transport protein; Provisional; Region: cysT; CHL00187 1198676002862 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1198676002863 dimer interface [polypeptide binding]; other site 1198676002864 conserved gate region; other site 1198676002865 putative PBP binding loops; other site 1198676002866 ABC-ATPase subunit interface; other site 1198676002867 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 1198676002868 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1198676002869 dimer interface [polypeptide binding]; other site 1198676002870 conserved gate region; other site 1198676002871 putative PBP binding loops; other site 1198676002872 ABC-ATPase subunit interface; other site 1198676002873 Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687 1198676002874 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 1198676002875 transcriptional antiterminator BglG; Provisional; Region: PRK09772 1198676002876 CAT RNA binding domain; Region: CAT_RBD; smart01061 1198676002877 PRD domain; Region: PRD; pfam00874 1198676002878 PRD domain; Region: PRD; pfam00874 1198676002879 PTS system, beta-glucoside-specific IIABC component; Region: PTS-II-ABC-beta; TIGR01995 1198676002880 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 1198676002881 active site turn [active] 1198676002882 phosphorylation site [posttranslational modification] 1198676002883 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 1198676002884 PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_glc; cd00210 1198676002885 HPr interaction site; other site 1198676002886 glycerol kinase (GK) interaction site [polypeptide binding]; other site 1198676002887 active site 1198676002888 phosphorylation site [posttranslational modification] 1198676002889 Predicted peptidase [General function prediction only]; Region: COG4099 1198676002890 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 1198676002891 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 1198676002892 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 1198676002893 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1198676002894 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1198676002895 Beta-glucosidase/6-phospho-beta-glucosidase/beta- galactosidase [Carbohydrate transport and metabolism]; Region: BglB; COG2723 1198676002896 beta-galactosidase; Region: BGL; TIGR03356 1198676002897 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1198676002898 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1198676002899 non-specific DNA binding site [nucleotide binding]; other site 1198676002900 salt bridge; other site 1198676002901 sequence-specific DNA binding site [nucleotide binding]; other site 1198676002902 Collagen binding domain; Region: Collagen_bind; pfam05737 1198676002903 Phospholipase_D-nuclease N-terminal; Region: PLDc_N; pfam13396 1198676002904 Phosphatidylserine/phosphatidylglycerophosphate/car diolipin synthases and related enzymes [Lipid metabolism]; Region: Cls; COG1502 1198676002905 Putative catalytic domain, repeat 1, of Streptococcus mutans uncharacterized protein SMU_988 and similar proteins; Region: PLDc_SMU_988_like_1; cd09154 1198676002906 putative active site [active] 1198676002907 catalytic site [active] 1198676002908 Putative catalytic domain, repeat 2, of Streptococcus mutans uncharacterized protein SMU_988 and similar proteins; Region: PLDc_SMU_988_like_2; cd09160 1198676002909 putative active site [active] 1198676002910 catalytic site [active] 1198676002911 aspartate-semialdehyde dehydrogenase; Provisional; Region: PRK14874 1198676002912 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 1198676002913 Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950 1198676002914 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 1198676002915 dimer interface [polypeptide binding]; other site 1198676002916 active site 1198676002917 catalytic residue [active] 1198676002918 ATP cone domain; Region: ATP-cone; pfam03477 1198676002919 GTPase YlqF; Reviewed; Region: rbgA; PRK09563 1198676002920 Circularly permuted YlqF GTPase; Region: YlqF; cd01856 1198676002921 GTP/Mg2+ binding site [chemical binding]; other site 1198676002922 G4 box; other site 1198676002923 G5 box; other site 1198676002924 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 1198676002925 G1 box; other site 1198676002926 G1 box; other site 1198676002927 GTP/Mg2+ binding site [chemical binding]; other site 1198676002928 Switch I region; other site 1198676002929 G2 box; other site 1198676002930 G2 box; other site 1198676002931 G3 box; other site 1198676002932 G3 box; other site 1198676002933 Switch II region; other site 1198676002934 Switch II region; other site 1198676002935 G5 box; other site 1198676002936 bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182 1198676002937 RNA/DNA hybrid binding site [nucleotide binding]; other site 1198676002938 active site 1198676002939 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cl00462 1198676002940 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 1198676002941 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1198676002942 ABC-ATPase subunit interface; other site 1198676002943 dimer interface [polypeptide binding]; other site 1198676002944 putative PBP binding regions; other site 1198676002945 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1198676002946 ABC-ATPase subunit interface; other site 1198676002947 dimer interface [polypeptide binding]; other site 1198676002948 putative PBP binding regions; other site 1198676002949 ABC-type enterochelin transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CeuD; COG4604 1198676002950 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 1198676002951 Walker A/P-loop; other site 1198676002952 ATP binding site [chemical binding]; other site 1198676002953 Q-loop/lid; other site 1198676002954 ABC transporter signature motif; other site 1198676002955 Walker B; other site 1198676002956 D-loop; other site 1198676002957 H-loop/switch region; other site 1198676002958 ABC-type enterochelin transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: CeuA; COG4607 1198676002959 Siderophore binding protein FatB. These proteins have been shown to function as ABC-type initial receptors in the siderophore-mediated iron uptake in some eubacterial species. They belong to the TroA superfamily of periplasmic metal binding proteins...; Region: FatB; cd01140 1198676002960 putative ligand binding residues [chemical binding]; other site 1198676002961 DNA recombination-mediator protein A; Region: DNA_processg_A; pfam02481 1198676002962 DNA protecting protein DprA; Region: dprA; TIGR00732 1198676002963 DNA topoisomerase I; Validated; Region: PRK05582 1198676002964 TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I. Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363 1198676002965 active site 1198676002966 interdomain interaction site; other site 1198676002967 putative metal-binding site [ion binding]; other site 1198676002968 nucleotide binding site [chemical binding]; other site 1198676002969 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 1198676002970 domain I; other site 1198676002971 DNA binding groove [nucleotide binding] 1198676002972 phosphate binding site [ion binding]; other site 1198676002973 domain II; other site 1198676002974 domain III; other site 1198676002975 nucleotide binding site [chemical binding]; other site 1198676002976 catalytic site [active] 1198676002977 domain IV; other site 1198676002978 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 1198676002979 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 1198676002980 tRNA (uracil-5-)-methyltransferase Gid; Reviewed; Region: PRK05335 1198676002981 Glucose inhibited division protein A; Region: GIDA; pfam01134 1198676002982 Glycosyl hydrolase family 70; Region: Glyco_hydro_70; pfam02324 1198676002983 Alpha amylase catalytic domain family; Region: AmyAc_family; cl07893 1198676002984 Putative cell wall binding repeat; Region: CW_binding_1; pfam01473 1198676002985 glucan-binding repeat; Region: glucan_65_rpt; TIGR04035 1198676002986 glucan-binding repeat; Region: glucan_65_rpt; TIGR04035 1198676002987 glucan-binding repeat; Region: glucan_65_rpt; TIGR04035 1198676002988 glucan-binding repeat; Region: glucan_65_rpt; TIGR04035 1198676002989 glucan-binding repeat; Region: glucan_65_rpt; TIGR04035 1198676002990 glucan-binding repeat; Region: glucan_65_rpt; TIGR04035 1198676002991 Glycosyl hydrolase family 70; Region: Glyco_hydro_70; pfam02324 1198676002992 Alpha amylase catalytic domain family; Region: AmyAc_family; cl07893 1198676002993 Putative cell wall binding repeat; Region: CW_binding_1; pfam01473 1198676002994 glucan-binding repeat; Region: glucan_65_rpt; TIGR04035 1198676002995 glucan-binding repeat; Region: glucan_65_rpt; TIGR04035 1198676002996 glucan-binding repeat; Region: glucan_65_rpt; TIGR04035 1198676002997 glucan-binding repeat; Region: glucan_65_rpt; TIGR04035 1198676002998 glucan-binding repeat; Region: glucan_65_rpt; TIGR04035 1198676002999 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 1198676003000 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 1198676003001 Walker A/P-loop; other site 1198676003002 ATP binding site [chemical binding]; other site 1198676003003 Q-loop/lid; other site 1198676003004 ABC transporter signature motif; other site 1198676003005 Walker B; other site 1198676003006 D-loop; other site 1198676003007 H-loop/switch region; other site 1198676003008 FtsX-like permease family; Region: FtsX; pfam02687 1198676003009 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1198676003010 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1198676003011 active site 1198676003012 phosphorylation site [posttranslational modification] 1198676003013 intermolecular recognition site; other site 1198676003014 dimerization interface [polypeptide binding]; other site 1198676003015 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1198676003016 DNA binding site [nucleotide binding] 1198676003017 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1198676003018 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1198676003019 ATP binding site [chemical binding]; other site 1198676003020 Mg2+ binding site [ion binding]; other site 1198676003021 G-X-G motif; other site 1198676003022 Citrate lyase synthetase [Energy production and conversion]; Region: CitC; COG3053 1198676003023 Citrate lyase ligase; Region: Citrate_lyase_ligase; cd02169 1198676003024 putative active site [active] 1198676003025 (T/H)XGH motif; other site 1198676003026 triphosphoribosyl-dephospho-CoA synthase CitG; Region: citrate_citG; TIGR03125 1198676003027 Transcriptional regulators [Transcription]; Region: GntR; COG1802 1198676003028 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1198676003029 DNA-binding site [nucleotide binding]; DNA binding site 1198676003030 FCD domain; Region: FCD; pfam07729 1198676003031 H+/citrate symporter [Energy production and conversion]; Region: CitM; COG2851 1198676003032 Citrate transporter; Region: CitMHS; pfam03600 1198676003033 acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated; Region: PRK06549 1198676003034 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 1198676003035 carboxyltransferase (CT) interaction site; other site 1198676003036 biotinylation site [posttranslational modification]; other site 1198676003037 Na+-transporting oxaloacetate decarboxylase beta subunit; Region: OAD_beta; pfam03977 1198676003038 Oxaloacetate decarboxylase, gamma chain; Region: OAD_gamma; cl01458 1198676003039 citrate lyase subunit gamma; Provisional; Region: PRK13253 1198676003040 HpcH/HpaI aldolase/citrate lyase family; Region: HpcH_HpaI; cl17231 1198676003041 Citrate lyase, alpha subunit (CitF); Region: CitF; pfam04223 1198676003042 Acetyl-CoA hydrolase/transferase C-terminal domain; Region: AcetylCoA_hyd_C; pfam13336 1198676003043 2'-(5''-triphosphoribosyl)-3'- dephospho-CoA:apo-citrate lyase; Reviewed; Region: citX; PRK01392 1198676003044 oxaloacetate decarboxylase; Provisional; Region: PRK12331 1198676003045 Pyruvate carboxylase and Transcarboxylase 5S, carboxyltransferase domain; Region: DRE_TIM_PC_TC_5S; cd07937 1198676003046 active site 1198676003047 catalytic residues [active] 1198676003048 metal binding site [ion binding]; metal-binding site 1198676003049 homodimer binding site [polypeptide binding]; other site 1198676003050 Integrase core domain; Region: rve_2; pfam13333 1198676003051 site-specific tyrosine recombinase XerS; Reviewed; Region: xerS; PRK05084 1198676003052 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 1198676003053 active site 1198676003054 DNA binding site [nucleotide binding] 1198676003055 Int/Topo IB signature motif; other site 1198676003056 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 1198676003057 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1198676003058 Walker A/P-loop; other site 1198676003059 ATP binding site [chemical binding]; other site 1198676003060 Q-loop/lid; other site 1198676003061 ABC transporter signature motif; other site 1198676003062 Walker B; other site 1198676003063 D-loop; other site 1198676003064 H-loop/switch region; other site 1198676003065 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 1198676003066 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1198676003067 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1198676003068 dimer interface [polypeptide binding]; other site 1198676003069 phosphorylation site [posttranslational modification] 1198676003070 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1198676003071 ATP binding site [chemical binding]; other site 1198676003072 Mg2+ binding site [ion binding]; other site 1198676003073 G-X-G motif; other site 1198676003074 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1198676003075 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1198676003076 active site 1198676003077 phosphorylation site [posttranslational modification] 1198676003078 intermolecular recognition site; other site 1198676003079 dimerization interface [polypeptide binding]; other site 1198676003080 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1198676003081 DNA binding site [nucleotide binding] 1198676003082 A4GalT_like proteins catalyze the addition of galactose or glucose residues to the lipooligosaccharide (LOS) or lipopolysaccharide (LPS) of the bacterial cell surface; Region: GT8_A4GalT_like; cd04194 1198676003083 Glycosyl transferase family 8; Region: Glyco_transf_8; pfam01501 1198676003084 Ligand binding site; other site 1198676003085 metal-binding site 1198676003086 classical (c) SDR, subgroup 5; Region: SDR_c5; cd05346 1198676003087 malonic semialdehyde reductase; Provisional; Region: PRK10538 1198676003088 putative NAD(P) binding site [chemical binding]; other site 1198676003089 homotetramer interface [polypeptide binding]; other site 1198676003090 homodimer interface [polypeptide binding]; other site 1198676003091 active site 1198676003092 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 1198676003093 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 1198676003094 Walker A/P-loop; other site 1198676003095 ATP binding site [chemical binding]; other site 1198676003096 Q-loop/lid; other site 1198676003097 ABC transporter signature motif; other site 1198676003098 Walker B; other site 1198676003099 D-loop; other site 1198676003100 H-loop/switch region; other site 1198676003101 phosphotransacetylase; Reviewed; Region: eutD; PRK09653 1198676003102 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 1198676003103 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 1198676003104 active site 1198676003105 inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK04885 1198676003106 ATP-NAD kinase; Region: NAD_kinase; pfam01513 1198676003107 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 1198676003108 synthetase active site [active] 1198676003109 NTP binding site [chemical binding]; other site 1198676003110 metal binding site [ion binding]; metal-binding site 1198676003111 Uncharacterized subgroup 1 of the CYTH-like superfamily; Region: CYTH-like_Pase_1; cd07762 1198676003112 putative active site [active] 1198676003113 putative metal binding residues [ion binding]; other site 1198676003114 signature motif; other site 1198676003115 putative triphosphate binding site [ion binding]; other site 1198676003116 ribose-phosphate pyrophosphokinase; Provisional; Region: PRK02458 1198676003117 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 1198676003118 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1198676003119 active site 1198676003120 Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104 1198676003121 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 1198676003122 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1198676003123 catalytic residue [active] 1198676003124 Putative amino acid metabolism; Region: DUF1831; pfam08866 1198676003125 redox-sensing transcriptional repressor Rex; Provisional; Region: PRK05472 1198676003126 Putative DNA-binding protein N-terminus; Region: Put_DNA-bind_N; pfam06971 1198676003127 CoA binding domain; Region: CoA_binding; pfam02629 1198676003128 Peptidase C26; Region: Peptidase_C26; pfam07722 1198676003129 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_2; cd01745 1198676003130 catalytic triad [active] 1198676003131 hypothetical protein; Reviewed; Region: PRK00024 1198676003132 Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071 1198676003133 MPN+ (JAMM) motif; other site 1198676003134 Zinc-binding site [ion binding]; other site 1198676003135 Protein of unknown function (DUF3307); Region: DUF3307; pfam11750 1198676003136 signal recognition particle protein; Provisional; Region: PRK10867 1198676003137 SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963 1198676003138 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 1198676003139 P loop; other site 1198676003140 GTP binding site [chemical binding]; other site 1198676003141 Signal peptide binding domain; Region: SRP_SPB; pfam02978 1198676003142 putative DNA-binding protein; Validated; Region: PRK00118 1198676003143 Putative helix-turn-helix protein, YlxM / p13 like; Region: UPF0122; pfam04297 1198676003144 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1198676003145 dimer interface [polypeptide binding]; other site 1198676003146 conserved gate region; other site 1198676003147 putative PBP binding loops; other site 1198676003148 ABC-ATPase subunit interface; other site 1198676003149 ABC-type proline/glycine betaine transport systems, periplasmic components [Amino acid transport and metabolism]; Region: ProX; COG2113 1198676003150 Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069 1198676003151 ABC-type proline/glycine betaine transport system, ATPase component [Amino acid transport and metabolism]; Region: ProV; COG4175 1198676003152 ATP-binding cassette domain of the osmoprotectant proline/glycine betaine uptake system; Region: ABC_Pro_Gly_Betaine; cd03294 1198676003153 Walker A/P-loop; other site 1198676003154 ATP binding site [chemical binding]; other site 1198676003155 Q-loop/lid; other site 1198676003156 ABC transporter signature motif; other site 1198676003157 Walker B; other site 1198676003158 D-loop; other site 1198676003159 H-loop/switch region; other site 1198676003160 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 1198676003161 potential frameshift: common BLAST hit: gi|290580498|ref|YP_003484890.1| transcriptional regulator 1198676003162 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 1198676003163 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1198676003164 DNA-binding site [nucleotide binding]; DNA binding site 1198676003165 UTRA domain; Region: UTRA; pfam07702 1198676003166 GMP synthase; Reviewed; Region: guaA; PRK00074 1198676003167 Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742 1198676003168 AMP/PPi binding site [chemical binding]; other site 1198676003169 candidate oxyanion hole; other site 1198676003170 catalytic triad [active] 1198676003171 potential glutamine specificity residues [chemical binding]; other site 1198676003172 The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997 1198676003173 ATP Binding subdomain [chemical binding]; other site 1198676003174 Dimerization subdomain; other site 1198676003175 ABC-2 family transporter protein; Region: ABC2_membrane_2; cl17866 1198676003176 ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698 1198676003177 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 1198676003178 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 1198676003179 Walker A/P-loop; other site 1198676003180 ATP binding site [chemical binding]; other site 1198676003181 Q-loop/lid; other site 1198676003182 ABC transporter signature motif; other site 1198676003183 Walker B; other site 1198676003184 D-loop; other site 1198676003185 H-loop/switch region; other site 1198676003186 LytTr DNA-binding domain; Region: LytTR; pfam04397 1198676003187 Alpha/beta hydrolase of unknown function (DUF915); Region: DUF915; pfam06028 1198676003188 Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247 1198676003189 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 1198676003190 formate--tetrahydrofolate ligase; Provisional; Region: PRK13505 1198676003191 Formyltetrahydrofolate synthetase (FTHFS) catalyzes the ATP-dependent activation of formate ion via its addition to the N10 position of tetrahydrofolate. FTHFS is a highly expressed key enzyme in both the Wood-Ljungdahl pathway of autotrophic CO2...; Region: FTHFS; cd00477 1198676003192 Potassium binding sites [ion binding]; other site 1198676003193 Cesium cation binding sites [ion binding]; other site 1198676003194 phosphopantothenate--cysteine ligase; Validated; Region: PRK06732 1198676003195 phosphopantothenoylcysteine decarboxylase, streptococcal; Region: coaC_strep; TIGR02113 1198676003196 Flavoprotein; Region: Flavoprotein; pfam02441 1198676003197 Predicted membrane protein [Function unknown]; Region: COG4684 1198676003198 phosphoglucomutase-2-like protein; Provisional; Region: PTZ00150 1198676003199 This CD includes PGM2 (phosphoglucomutase 2) and PGM2L1 (phosphoglucomutase 2-like 1). The mammalian PGM2 is thought to be a phosphopentomutase that catalyzes the conversion of the nucleoside breakdown products, ribose-1-phosphate and...; Region: PGM2; cd05799 1198676003200 active site 1198676003201 substrate binding site [chemical binding]; other site 1198676003202 metal binding site [ion binding]; metal-binding site 1198676003203 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 1198676003204 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1198676003205 ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254 1198676003206 Walker A/P-loop; other site 1198676003207 ATP binding site [chemical binding]; other site 1198676003208 Q-loop/lid; other site 1198676003209 ABC transporter signature motif; other site 1198676003210 Walker B; other site 1198676003211 D-loop; other site 1198676003212 H-loop/switch region; other site 1198676003213 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 1198676003214 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1198676003215 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1198676003216 Walker A/P-loop; other site 1198676003217 ATP binding site [chemical binding]; other site 1198676003218 Q-loop/lid; other site 1198676003219 ABC transporter signature motif; other site 1198676003220 Walker B; other site 1198676003221 D-loop; other site 1198676003222 H-loop/switch region; other site 1198676003223 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 1198676003224 N-acetyl-D-glucosamine binding site [chemical binding]; other site 1198676003225 catalytic residue [active] 1198676003226 37-kD nucleoid-associated bacterial protein; Region: NA37; pfam04245 1198676003227 serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011 1198676003228 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378 1198676003229 dimer interface [polypeptide binding]; other site 1198676003230 active site 1198676003231 glycine-pyridoxal phosphate binding site [chemical binding]; other site 1198676003232 folate binding site [chemical binding]; other site 1198676003233 Putative translation factor (SUA5) [Translation, ribosomal structure and biogenesis]; Region: SUA5; COG0009 1198676003234 protein-(glutamine-N5) methyltransferase, release factor-specific; Region: RF_mod_PrmC; TIGR03534 1198676003235 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1198676003236 S-adenosylmethionine binding site [chemical binding]; other site 1198676003237 peptide chain release factor 1; Validated; Region: prfA; PRK00591 1198676003238 This domain is found in peptide chain release factors; Region: PCRF; smart00937 1198676003239 RF-1 domain; Region: RF-1; pfam00472 1198676003240 thymidine kinase; Provisional; Region: PRK04296 1198676003241 4-oxalocrotonate tautomerase; Provisional; Region: PRK02289 1198676003242 active site 1 [active] 1198676003243 dimer interface [polypeptide binding]; other site 1198676003244 hexamer interface [polypeptide binding]; other site 1198676003245 active site 2 [active] 1198676003246 potential frameshift: common BLAST hit: gi|387786128|ref|YP_006251224.1| putative thiamine biosynthesis lipoprotein 1198676003247 Predicted flavoprotein [General function prediction only]; Region: COG0431 1198676003248 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 1198676003249 Predicted flavoprotein [General function prediction only]; Region: COG0431 1198676003250 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 1198676003251 PAS domain; Region: PAS_10; pfam13596 1198676003252 putative cross-wall-targeting lipoprotein signal; Region: strep_RK_lipo; TIGR03726 1198676003253 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 1198676003254 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 1198676003255 FtsX-like permease family; Region: FtsX; pfam02687 1198676003256 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 1198676003257 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 1198676003258 Walker A/P-loop; other site 1198676003259 ATP binding site [chemical binding]; other site 1198676003260 Q-loop/lid; other site 1198676003261 ABC transporter signature motif; other site 1198676003262 Walker B; other site 1198676003263 D-loop; other site 1198676003264 H-loop/switch region; other site 1198676003265 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1198676003266 dimer interface [polypeptide binding]; other site 1198676003267 conserved gate region; other site 1198676003268 ABC-ATPase subunit interface; other site 1198676003269 Periplasmic glycine betaine/choline-binding (lipo)protein of an ABC-type transport system (osmoprotectant binding protein) [Cell envelope biogenesis, outer membrane]; Region: OpuBC; COG1732 1198676003270 ABC-type proline/glycine betaine transport systems, periplasmic components [Amino acid transport and metabolism]; Region: ProX; cl17891 1198676003271 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 1198676003272 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1198676003273 Walker A/P-loop; other site 1198676003274 ATP binding site [chemical binding]; other site 1198676003275 Q-loop/lid; other site 1198676003276 ABC transporter signature motif; other site 1198676003277 Walker B; other site 1198676003278 D-loop; other site 1198676003279 H-loop/switch region; other site 1198676003280 potential frameshift: common BLAST hit: gi|24379533|ref|NP_721488.1| transcriptional regulator protein 1198676003281 Quinone oxidoreductase (QOR); Region: quinone_oxidoreductase_like_1; cd08243 1198676003282 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 1198676003283 putative NAD(P) binding site [chemical binding]; other site 1198676003284 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 1198676003285 6-phospho-beta-glucosidase; Reviewed; Region: arb; PRK09593 1198676003286 beta-galactosidase; Region: BGL; TIGR03356 1198676003287 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1198676003288 catalytic core [active] 1198676003289 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1198676003290 catalytic core [active] 1198676003291 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 1198676003292 NnaC (CMP-NeuNAc synthetase) _like subfamily of SGNH_hydrolases, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its...; Region: NnaC_like; cd01841 1198676003293 active site 1198676003294 catalytic triad [active] 1198676003295 oxyanion hole [active] 1198676003296 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1198676003297 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 1198676003298 active site 1198676003299 motif I; other site 1198676003300 motif II; other site 1198676003301 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 1198676003302 Mn2+ and Fe2+ transporters of the NRAMP family [Inorganic ion transport and metabolism]; Region: MntH; COG1914 1198676003303 Predicted secreted protein [Function unknown]; Region: COG4086 1198676003304 Protein of unknown function (DUF1002); Region: DUF1002; pfam06207 1198676003305 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_1; cd08352 1198676003306 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1198676003307 putative metal binding site [ion binding]; other site 1198676003308 Sortase A (SrtA) or subfamily-1 sortases are cysteine transpeptidases found in gram-positive bacteria that anchor surface proteins to peptidoglycans of the bacterial cell wall envelope. They do so by catalyzing a transpeptidation reaction in which the...; Region: Sortase_A_1; cd06165 1198676003309 active site 1198676003310 catalytic site [active] 1198676003311 DNA gyrase subunit A; Validated; Region: PRK05560 1198676003312 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 1198676003313 CAP-like domain; other site 1198676003314 active site 1198676003315 primary dimer interface [polypeptide binding]; other site 1198676003316 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1198676003317 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1198676003318 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1198676003319 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1198676003320 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1198676003321 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1198676003322 L-lactate dehydrogenase; Reviewed; Region: ldh; PRK00066 1198676003323 L-2-hydroxyisocapronate dehydrogenases and some bacterial L-lactate dehydrogenases; Region: HicDH_like; cd05291 1198676003324 tetramer (dimer of dimers) interface [polypeptide binding]; other site 1198676003325 NAD binding site [chemical binding]; other site 1198676003326 dimer interface [polypeptide binding]; other site 1198676003327 substrate binding site [chemical binding]; other site 1198676003328 coenzyme A disulfide reductase; Reviewed; Region: PRK09564 1198676003329 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1198676003330 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 1198676003331 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 1198676003332 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 1198676003333 TM-ABC transporter signature motif; other site 1198676003334 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 1198676003335 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 1198676003336 TM-ABC transporter signature motif; other site 1198676003337 ABC-type uncharacterized transport systems, ATPase components [General function prediction only]; Region: COG3845 1198676003338 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 1198676003339 Walker A/P-loop; other site 1198676003340 ATP binding site [chemical binding]; other site 1198676003341 Q-loop/lid; other site 1198676003342 ABC transporter signature motif; other site 1198676003343 Walker B; other site 1198676003344 D-loop; other site 1198676003345 H-loop/switch region; other site 1198676003346 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 1198676003347 Uncharacterized ABC-type transport system, periplasmic component/surface lipoprotein [General function prediction only]; Region: Med; COG1744 1198676003348 Periplasmic binding domain of basic membrane lipoprotein, PnrA, in Treponema pallidum and its homologs from other bacteria and Archaea; Region: PBP1_BmpA_PnrA_like; cd06354 1198676003349 ligand binding site [chemical binding]; other site 1198676003350 Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283 1198676003351 active site 1198676003352 catalytic motif [active] 1198676003353 Zn binding site [ion binding]; other site 1198676003354 2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family; Region: DeoC; cd00959 1198676003355 intersubunit interface [polypeptide binding]; other site 1198676003356 active site 1198676003357 catalytic residue [active] 1198676003358 pyrimidine-nucleoside phosphorylase; Reviewed; Region: PRK06078 1198676003359 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 1198676003360 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 1198676003361 Pyrimidine nucleoside phosphorylase C-terminal domain; Region: PYNP_C; pfam07831 1198676003362 16S RNA G1207 methylase RsmC [Translation, ribosomal structure and biogenesis]; Region: RsmC; COG2813 1198676003363 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1198676003364 S-adenosylmethionine binding site [chemical binding]; other site 1198676003365 pantothenate kinase; Provisional; Region: PRK05439 1198676003366 Pantothenate kinase (PanK) catalyzes the phosphorylation of pantothenic acid to form 4'-phosphopantothenic, which is the first of five steps in coenzyme A (CoA) biosynthetic pathway. The reaction carried out by this enzyme is a key regulatory point...; Region: PanK; cd02025 1198676003367 ATP-binding site [chemical binding]; other site 1198676003368 CoA-binding site [chemical binding]; other site 1198676003369 Mg2+-binding site [ion binding]; other site 1198676003370 30S ribosomal protein S20; Reviewed; Region: rpsT; PRK00239 1198676003371 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1198676003372 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1198676003373 dimer interface [polypeptide binding]; other site 1198676003374 phosphorylation site [posttranslational modification] 1198676003375 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1198676003376 ATP binding site [chemical binding]; other site 1198676003377 Mg2+ binding site [ion binding]; other site 1198676003378 G-X-G motif; other site 1198676003379 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1198676003380 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1198676003381 active site 1198676003382 phosphorylation site [posttranslational modification] 1198676003383 intermolecular recognition site; other site 1198676003384 dimerization interface [polypeptide binding]; other site 1198676003385 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1198676003386 DNA binding site [nucleotide binding] 1198676003387 Aminopeptidase N [Amino acid transport and metabolism]; Region: PepN; COG0308 1198676003388 Peptidase M1 Aminopeptidase N family incudes tricorn interacting factor F3, Endoplasmic reticulum aminopeptidase 1 (ERAP1), Aminopeptidase Q (APQ); Region: M1_APN_2; cd09601 1198676003389 Zn binding site [ion binding]; other site 1198676003390 phosphate transport system regulatory protein PhoU; Region: phoU_full; TIGR02135 1198676003391 PhoU domain; Region: PhoU; pfam01895 1198676003392 PhoU domain; Region: PhoU; pfam01895 1198676003393 phosphate transporter ATP-binding protein; Provisional; Region: PRK14239 1198676003394 ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260 1198676003395 Walker A/P-loop; other site 1198676003396 ATP binding site [chemical binding]; other site 1198676003397 Q-loop/lid; other site 1198676003398 ABC transporter signature motif; other site 1198676003399 Walker B; other site 1198676003400 D-loop; other site 1198676003401 H-loop/switch region; other site 1198676003402 potential frameshift: common BLAST hit: gi|24379566|ref|NP_721521.1| phosphate transporter ATP-binding protein 1198676003403 ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstA; COG0581 1198676003404 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1198676003405 dimer interface [polypeptide binding]; other site 1198676003406 conserved gate region; other site 1198676003407 putative PBP binding loops; other site 1198676003408 ABC-ATPase subunit interface; other site 1198676003409 ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstC; COG0573 1198676003410 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1198676003411 dimer interface [polypeptide binding]; other site 1198676003412 conserved gate region; other site 1198676003413 putative PBP binding loops; other site 1198676003414 ABC-ATPase subunit interface; other site 1198676003415 phosphate binding protein; Region: ptsS_2; TIGR02136 1198676003416 tRNA and rRNA cytosine-C5-methylases [Translation, ribosomal structure and biogenesis]; Region: Sun; COG0144 1198676003417 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1198676003418 S-adenosylmethionine binding site [chemical binding]; other site 1198676003419 Uncharacterized conserved protein [Function unknown]; Region: COG3270 1198676003420 pre-rRNA processing and ribosome biogenesis; Region: Nol1_Nop2_Fmu_2; pfam13636 1198676003421 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 1198676003422 Inositol-monophosphatase-like domains. This family of phosphatases is dependent on bivalent metal ions such as Mg++, and many members are inhibited by Li+ (which is thought to displace a bivalent ion in the active site). Substrates include fructose-1; Region: IMPase_like; cd01637 1198676003423 active site 1198676003424 hypothetical protein; Provisional; Region: PRK04387 1198676003425 Arsenate Reductase (ArsC) family, Spx subfamily; Spx is a unique RNA polymerase (RNAP)-binding protein present in bacilli and some mollicutes. It inhibits transcription by binding to the C-terminal domain of the alpha subunit of RNAP, disrupting complex...; Region: ArsC_Spx; cd03032 1198676003426 ArsC family; Region: ArsC; pfam03960 1198676003427 putative catalytic residues [active] 1198676003428 thiol/disulfide switch; other site 1198676003429 bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627 1198676003430 FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064 1198676003431 active site 1198676003432 Riboflavin kinase; Region: Flavokinase; smart00904 1198676003433 Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573 1198676003434 RNA binding site [nucleotide binding]; other site 1198676003435 tRNA Pseudouridine synthase II, C terminal; Region: TruB_C; pfam09142 1198676003436 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1198676003437 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1198676003438 dimer interface [polypeptide binding]; other site 1198676003439 phosphorylation site [posttranslational modification] 1198676003440 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1198676003441 ATP binding site [chemical binding]; other site 1198676003442 Mg2+ binding site [ion binding]; other site 1198676003443 G-X-G motif; other site 1198676003444 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1198676003445 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1198676003446 active site 1198676003447 phosphorylation site [posttranslational modification] 1198676003448 intermolecular recognition site; other site 1198676003449 dimerization interface [polypeptide binding]; other site 1198676003450 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1198676003451 DNA binding site [nucleotide binding] 1198676003452 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 1198676003453 ATP-binding cassette domain of the bacitracin-resistance transporter; Region: ABC_BcrA_bacitracin_resist; cd03268 1198676003454 Walker A/P-loop; other site 1198676003455 ATP binding site [chemical binding]; other site 1198676003456 Q-loop/lid; other site 1198676003457 ABC transporter signature motif; other site 1198676003458 Walker B; other site 1198676003459 D-loop; other site 1198676003460 H-loop/switch region; other site 1198676003461 lantibiotic protection ABC transporter permease subunit, MutG family; Region: lanti_perm_MutG; TIGR03733 1198676003462 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 1198676003463 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 1198676003464 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4200 1198676003465 Uncharacterized conserved protein [Function unknown]; Region: COG2461 1198676003466 Family of unknown function (DUF438); Region: DUF438; pfam04282 1198676003467 Hemerythrin HHE cation binding domain; Region: Hemerythrin; pfam01814 1198676003468 Domain of unknown function (DUF1858); Region: DUF1858; pfam08984 1198676003469 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 1198676003470 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1198676003471 Coenzyme A binding pocket [chemical binding]; other site 1198676003472 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4487 1198676003473 Uncharacterized protein conserved in bacteria (DUF2130); Region: DUF2130; pfam09903 1198676003474 Protein of unknown function DUF262; Region: DUF262; pfam03235 1198676003475 Abortive infection C-terminus; Region: Abi_C; pfam14355 1198676003476 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 1198676003477 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1198676003478 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1198676003479 Walker A/P-loop; other site 1198676003480 ATP binding site [chemical binding]; other site 1198676003481 Q-loop/lid; other site 1198676003482 ABC transporter signature motif; other site 1198676003483 Walker B; other site 1198676003484 D-loop; other site 1198676003485 H-loop/switch region; other site 1198676003486 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 1198676003487 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1198676003488 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1198676003489 Walker A/P-loop; other site 1198676003490 ATP binding site [chemical binding]; other site 1198676003491 Q-loop/lid; other site 1198676003492 ABC transporter signature motif; other site 1198676003493 Walker B; other site 1198676003494 D-loop; other site 1198676003495 H-loop/switch region; other site 1198676003496 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1198676003497 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1198676003498 FtsX-like permease family; Region: FtsX; pfam02687 1198676003499 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 1198676003500 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 1198676003501 FtsX-like permease family; Region: FtsX; pfam02687 1198676003502 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 1198676003503 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 1198676003504 Walker A/P-loop; other site 1198676003505 ATP binding site [chemical binding]; other site 1198676003506 Q-loop/lid; other site 1198676003507 ABC transporter signature motif; other site 1198676003508 Walker B; other site 1198676003509 D-loop; other site 1198676003510 H-loop/switch region; other site 1198676003511 probable dihydroxyacetone kinase regulator; Region: DHAK_reg; TIGR02366 1198676003512 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1198676003513 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 1198676003514 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 1198676003515 catalytic residues [active] 1198676003516 Cytochrome c biogenesis protein [Posttranslational modification, protein turnover, chaperones]; Region: CcdA; COG0785 1198676003517 Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788 1198676003518 HAD-superfamily hydrolase, subfamily IIB; Region: HAD-SF-IIB; TIGR01484 1198676003519 Kynurenine formamidase [Amino acid transport and metabolism]; Region: COG1878 1198676003520 O-acetylhomoserine sulfhydrylase [Amino acid transport and metabolism]; Region: MET17; COG2873 1198676003521 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 1198676003522 homodimer interface [polypeptide binding]; other site 1198676003523 substrate-cofactor binding pocket; other site 1198676003524 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1198676003525 catalytic residue [active] 1198676003526 ATP-dependent DNA helicase PcrA; Region: pcrA; TIGR01073 1198676003527 Part of AAA domain; Region: AAA_19; pfam13245 1198676003528 Family description; Region: UvrD_C_2; pfam13538 1198676003529 Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115 1198676003530 Sodium:alanine symporter family; Region: Na_Ala_symp; cl00548 1198676003531 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 1198676003532 cation diffusion facilitator family transporter; Region: CDF; TIGR01297 1198676003533 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 1198676003534 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1198676003535 substrate binding pocket [chemical binding]; other site 1198676003536 membrane-bound complex binding site; other site 1198676003537 hinge residues; other site 1198676003538 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 1198676003539 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1198676003540 Walker A/P-loop; other site 1198676003541 ATP binding site [chemical binding]; other site 1198676003542 Q-loop/lid; other site 1198676003543 ABC transporter signature motif; other site 1198676003544 Walker B; other site 1198676003545 D-loop; other site 1198676003546 H-loop/switch region; other site 1198676003547 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 1198676003548 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1198676003549 dimer interface [polypeptide binding]; other site 1198676003550 conserved gate region; other site 1198676003551 ABC-ATPase subunit interface; other site 1198676003552 Uncharacterized Zn-ribbon-containing protein involved in phosphonate metabolism [Inorganic ion transport and metabolism]; Region: PhnA; COG2824 1198676003553 PhnA Zinc-Ribbon; Region: PhnA_Zn_Ribbon; pfam08274 1198676003554 PhnA protein; Region: PhnA; pfam03831 1198676003555 mannitol-1-phosphate 5-dehydrogenase; Provisional; Region: PRK02318 1198676003556 Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232 1198676003557 Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125 1198676003558 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 1198676003559 active site 1198676003560 phosphorylation site [posttranslational modification] 1198676003561 Transcriptional antiterminator [Transcription]; Region: BglG; COG3711 1198676003562 HTH domain; Region: HTH_11; pfam08279 1198676003563 Phosphotransferase system, mannitol-specific IIBC component [Carbohydrate transport and metabolism]; Region: MtlA; COG2213 1198676003564 PTS system, mannitol-specific IIC component; Region: mtlA; TIGR00851 1198676003565 PTS_IIB_mannitol: subunit IIB of enzyme II (EII) of the mannitol-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is a mannitol-specific permease with two cytoplasmic domains (IIA and IIB) and a transmembrane...; Region: PTS_IIB_mannitol; cd05567 1198676003566 active site 1198676003567 P-loop; other site 1198676003568 phosphorylation site [posttranslational modification] 1198676003569 PTS_IIB_mannitol: subunit IIB of enzyme II (EII) of the mannitol-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is a mannitol-specific permease with two cytoplasmic domains (IIA and IIB) and a transmembrane...; Region: PTS_IIB_mannitol; cd05567 1198676003570 active site 1198676003571 P-loop; other site 1198676003572 phosphorylation site [posttranslational modification] 1198676003573 glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331 1198676003574 Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans). The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714 1198676003575 glutaminase active site [active] 1198676003576 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 1198676003577 dimer interface [polypeptide binding]; other site 1198676003578 active site 1198676003579 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 1198676003580 dimer interface [polypeptide binding]; other site 1198676003581 active site 1198676003582 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 1198676003583 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 1198676003584 Predicted membrane protein [Function unknown]; Region: COG2261 1198676003585 pyruvate kinase; Provisional; Region: PRK05826 1198676003586 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342 1198676003587 domain interfaces; other site 1198676003588 active site 1198676003589 Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to a subfamily of the PFKA family (cd00363) and include bacterial ATP-dependent...; Region: Bacterial_PFK; cd00763 1198676003590 6-phosphofructokinase; Region: PFKA_ATP; TIGR02482 1198676003591 active site 1198676003592 ADP/pyrophosphate binding site [chemical binding]; other site 1198676003593 dimerization interface [polypeptide binding]; other site 1198676003594 allosteric effector site; other site 1198676003595 fructose-1,6-bisphosphate binding site; other site 1198676003596 DNA polymerase III DnaE; Reviewed; Region: dnaE; PRK07279 1198676003597 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III; Region: PHP_PolIIIA; cd07431 1198676003598 active site 1198676003599 PHP Thumb interface [polypeptide binding]; other site 1198676003600 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 1198676003601 generic binding surface II; other site 1198676003602 generic binding surface I; other site 1198676003603 Predicted transcriptional regulators [Transcription]; Region: COG1725 1198676003604 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1198676003605 DNA-binding site [nucleotide binding]; DNA binding site 1198676003606 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 1198676003607 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 1198676003608 Walker A/P-loop; other site 1198676003609 ATP binding site [chemical binding]; other site 1198676003610 Q-loop/lid; other site 1198676003611 ABC transporter signature motif; other site 1198676003612 Walker B; other site 1198676003613 D-loop; other site 1198676003614 H-loop/switch region; other site 1198676003615 Domain of Unknown Function with PDB structure (DUF3862); Region: DUF3862; pfam12978 1198676003616 Uncharacterized conserved protein [Function unknown]; Region: COG0398 1198676003617 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 1198676003618 30S ribosomal protein S1; Reviewed; Region: rpsA; PRK06676 1198676003619 S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687 1198676003620 RNA binding site [nucleotide binding]; other site 1198676003621 S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465 1198676003622 RNA binding site [nucleotide binding]; other site 1198676003623 S1_RPS1_repeat_ec3: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec3; cd05688 1198676003624 RNA binding site [nucleotide binding]; other site 1198676003625 S1_RPS1_repeat_hs4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_hs4; cd05692 1198676003626 RNA binding site [nucleotide binding]; other site 1198676003627 Protein of unknown function (DUF2969); Region: DUF2969; pfam11184 1198676003628 branched-chain amino acid aminotransferase; Provisional; Region: PRK13357 1198676003629 BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557 1198676003630 homodimer interface [polypeptide binding]; other site 1198676003631 substrate-cofactor binding pocket; other site 1198676003632 catalytic residue [active] 1198676003633 DNA topoisomerase IV, A subunit, Gram-positive; Region: parC_Gpos; TIGR01061 1198676003634 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 1198676003635 CAP-like domain; other site 1198676003636 active site 1198676003637 primary dimer interface [polypeptide binding]; other site 1198676003638 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1198676003639 RelA- and SpoT-like ppGpp Synthetases and Hydrolases, catalytic domain; Region: Rel-Spo_like; cl11966 1198676003640 metal binding triad [ion binding]; metal-binding site 1198676003641 DNA topoisomerase IV, B subunit, Gram-positive; Region: parE_Gpos; TIGR01058 1198676003642 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1198676003643 Mg2+ binding site [ion binding]; other site 1198676003644 G-X-G motif; other site 1198676003645 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 1198676003646 anchoring element; other site 1198676003647 dimer interface [polypeptide binding]; other site 1198676003648 ATP binding site [chemical binding]; other site 1198676003649 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 1198676003650 active site 1198676003651 putative metal-binding site [ion binding]; other site 1198676003652 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 1198676003653 putative glycerol-3-phosphate acyltransferase PlsY; Provisional; Region: PRK00220 1198676003654 potential frameshift: common BLAST hit: gi|387786021|ref|YP_006251117.1| putative 5'-nucleotidase precursor 1198676003655 dihydroorotase; Validated; Region: pyrC; PRK09357 1198676003656 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 1198676003657 Dihydroorotase (DHOase), subgroup IIa; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This subgroup also contains proteins that lack the active site, like unc-33, a C; Region: DHOase_IIa; cd01317 1198676003658 active site 1198676003659 Family 1 of Uracil-DNA glycosylase (UDG) enzymes; Region: UDG_F1; cd10027 1198676003660 ligand binding site [chemical binding]; other site 1198676003661 active site 1198676003662 UGI interface [polypeptide binding]; other site 1198676003663 catalytic site [active] 1198676003664 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1198676003665 dimer interface [polypeptide binding]; other site 1198676003666 conserved gate region; other site 1198676003667 putative PBP binding loops; other site 1198676003668 ABC-ATPase subunit interface; other site 1198676003669 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1198676003670 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 1198676003671 substrate binding pocket [chemical binding]; other site 1198676003672 membrane-bound complex binding site; other site 1198676003673 hinge residues; other site 1198676003674 amidase; Provisional; Region: PRK06529 1198676003675 Amidase; Region: Amidase; cl11426 1198676003676 Protein of unknown function (DUF419); Region: DUF419; pfam04237 1198676003677 PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in bacteria and archaea; Region: PEBP_bact_arch; cd00865 1198676003678 substrate binding site [chemical binding]; other site 1198676003679 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1198676003680 active site 1198676003681 Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725 1198676003682 active site 1198676003683 dimer interface [polypeptide binding]; other site 1198676003684 dihydroorotate dehydrogenase (subfamily 1) family protein; Region: pyrD_sub1_fam; TIGR01037 1198676003685 Dihydroorotate dehydrogenase (DHOD) class 1B FMN-binding domain. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine...; Region: DHOD_1B_like; cd04740 1198676003686 heterodimer interface [polypeptide binding]; other site 1198676003687 active site 1198676003688 FMN binding site [chemical binding]; other site 1198676003689 homodimer interface [polypeptide binding]; other site 1198676003690 substrate binding site [chemical binding]; other site 1198676003691 dihydroorotate dehydrogenase electron transfer subunit; Reviewed; Region: PRK00054 1198676003692 FAD/NAD binding domain in the electron transfer subunit of dihydroorotate dehydrogenase. Dihydroorotate dehydrogenases (DHODs) catalyze the only redox reaction in pyrimidine de novo biosynthesis. They catalyze the oxidation of (S)-dihydroorotate to...; Region: DHOD_e_trans; cd06218 1198676003693 FAD binding pocket [chemical binding]; other site 1198676003694 FAD binding motif [chemical binding]; other site 1198676003695 phosphate binding motif [ion binding]; other site 1198676003696 beta-alpha-beta structure motif; other site 1198676003697 NAD binding pocket [chemical binding]; other site 1198676003698 Iron coordination center [ion binding]; other site 1198676003699 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1198676003700 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1198676003701 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 1198676003702 dimerization interface [polypeptide binding]; other site 1198676003703 CRISPR/Cas system-associated protein Csm6; Region: Csm6_III-A; cl09873 1198676003704 purine nucleoside phosphorylase; Reviewed; Region: deoD; PRK05819 1198676003705 Uridine phosphorylase [Nucleotide transport and metabolism]; Region: Udp; COG2820 1198676003706 GMP synthase - Glutamine amidotransferase domain [Nucleotide transport and metabolism]; Region: GuaA; COG0518 1198676003707 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_1; cd01741 1198676003708 catalytic triad [active] 1198676003709 purine nucleoside phosphorylase; Provisional; Region: PRK08202 1198676003710 Protein of unknown function (DUF1643); Region: DUF1643; pfam07799 1198676003711 phosphopentomutase; Provisional; Region: PRK05362 1198676003712 Metalloenzyme superfamily; Region: Metalloenzyme; pfam01676 1198676003713 RPI_A: Ribose 5-phosphate isomerase type A (RPI_A) subfamily; RPI catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate, the first step of the non-oxidative branch of the pentose phosphate pathway. This reaction leads to the...; Region: RPI_A; cd01398 1198676003714 tetramer (dimer of dimers) interface [polypeptide binding]; other site 1198676003715 active site 1198676003716 dimer interface [polypeptide binding]; other site 1198676003717 tRNA modification GTPase TrmE; Reviewed; Region: trmE; PRK05291 1198676003718 GTP-binding protein TrmE N-terminus; Region: TrmE_N; pfam10396 1198676003719 trmE is a tRNA modification GTPase; Region: trmE; cd04164 1198676003720 G1 box; other site 1198676003721 GTP/Mg2+ binding site [chemical binding]; other site 1198676003722 Switch I region; other site 1198676003723 G2 box; other site 1198676003724 Switch II region; other site 1198676003725 G3 box; other site 1198676003726 G4 box; other site 1198676003727 G5 box; other site 1198676003728 Catalytic cysteine-containing C-terminus of GTPase, MnmE; Region: GTPase_Cys_C; pfam12631 1198676003729 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 1198676003730 SnoaL-like domain; Region: SnoaL_2; pfam12680 1198676003731 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1198676003732 dimerization interface [polypeptide binding]; other site 1198676003733 putative DNA binding site [nucleotide binding]; other site 1198676003734 putative Zn2+ binding site [ion binding]; other site 1198676003735 Uncharacterized subfamily of Uracil-DNA glycosylases; Region: UDG_like_1; cd10033 1198676003736 putative uracil binding site [chemical binding]; other site 1198676003737 putative active site [active] 1198676003738 dipeptidase PepV; Reviewed; Region: PRK07318 1198676003739 M20 Peptidase Xaa-His dipeptidase (PepV) degrades hydrophobic dipeptides; Region: M20_PepV; cd03888 1198676003740 active site 1198676003741 metal binding site [ion binding]; metal-binding site 1198676003742 Nitroreductase-like family 1. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_1; cd02137 1198676003743 dimer interface [polypeptide binding]; other site 1198676003744 FMN binding site [chemical binding]; other site 1198676003745 Bacteriophage abortive infection AbiH; Region: AbiH; pfam14253 1198676003746 excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558 1198676003747 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 1198676003748 GIY-YIG motif/motif A; other site 1198676003749 active site 1198676003750 catalytic site [active] 1198676003751 putative DNA binding site [nucleotide binding]; other site 1198676003752 metal binding site [ion binding]; metal-binding site 1198676003753 UvrB/uvrC motif; Region: UVR; pfam02151 1198676003754 UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459 1198676003755 Bacterial low temperature requirement A protein (LtrA); Region: LtrA; cl01754 1198676003756 HAD superfamily (subfamily IA) hydrolase, TIGR02254; Region: YjjG/YfnB 1198676003757 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1198676003758 active site 1198676003759 motif I; other site 1198676003760 motif II; other site 1198676003761 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1198676003762 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1198676003763 enolase; Provisional; Region: eno; PRK00077 1198676003764 Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313 1198676003765 dimer interface [polypeptide binding]; other site 1198676003766 metal binding site [ion binding]; metal-binding site 1198676003767 substrate binding pocket [chemical binding]; other site 1198676003768 Protein of unknown function (DUF2681); Region: DUF2681; pfam10883 1198676003769 Domain of unknown function (DUF4352); Region: DUF4352; pfam11611 1198676003770 Protein of unknown function (DUF1694); Region: DUF1694; pfam07997 1198676003771 Glycerate kinase [Carbohydrate transport and metabolism]; Region: COG1929 1198676003772 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1198676003773 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 1198676003774 Coenzyme A binding pocket [chemical binding]; other site 1198676003775 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 1198676003776 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1198676003777 motif II; other site 1198676003778 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1198676003779 non-specific DNA binding site [nucleotide binding]; other site 1198676003780 salt bridge; other site 1198676003781 sequence-specific DNA binding site [nucleotide binding]; other site 1198676003782 Plasmid maintenance system killer protein; Region: Plasmid_killer; cl01422 1198676003783 Domain of unknown function (DUF3387); Region: DUF3387; pfam11867 1198676003784 N-terminal putative catalytic domain of uncharacterized HKD family nucleases fused to putative helicases from the Snf2-like family; Region: PLDc_N_Snf2_like; cd09178 1198676003785 PLD-like domain; Region: PLDc_2; pfam13091 1198676003786 putative homodimer interface [polypeptide binding]; other site 1198676003787 putative active site [active] 1198676003788 catalytic site [active] 1198676003789 DEAD-like helicases superfamily; Region: DEXDc; smart00487 1198676003790 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1198676003791 ATP binding site [chemical binding]; other site 1198676003792 putative Mg++ binding site [ion binding]; other site 1198676003793 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1198676003794 nucleotide binding region [chemical binding]; other site 1198676003795 ATP-binding site [chemical binding]; other site 1198676003796 multiple promoter invertase; Provisional; Region: mpi; PRK13413 1198676003797 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768 1198676003798 catalytic residues [active] 1198676003799 catalytic nucleophile [active] 1198676003800 Presynaptic Site I dimer interface [polypeptide binding]; other site 1198676003801 Synaptic Antiparallel dimer interface [polypeptide binding]; other site 1198676003802 Synaptic Flat tetramer interface [polypeptide binding]; other site 1198676003803 Synaptic Site I dimer interface [polypeptide binding]; other site 1198676003804 DNA binding site [nucleotide binding] 1198676003805 Homeodomain-like domain; Region: HTH_23; pfam13384 1198676003806 TaqI-like C-terminal specificity domain; Region: TaqI_C; pfam12950 1198676003807 Eco57I restriction-modification methylase; Region: Eco57I; pfam07669 1198676003808 TaqI-like C-terminal specificity domain; Region: TaqI_C; pfam12950 1198676003809 PemK-like protein; Region: PemK; pfam02452 1198676003810 DivIVA protein; Region: DivIVA; pfam05103 1198676003811 DivIVA domain; Region: DivI1A_domain; TIGR03544 1198676003812 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in Escherichia coli phosphoribosyl-ATP pyrophosphohydrolase (HisIE or PRATP-PH) and its homologs; Region: NTP-PPase_HisIE_like; cd11534 1198676003813 metal binding site [ion binding]; metal-binding site 1198676003814 phosphoribosyl-AMP cyclohydrolase; Reviewed; Region: hisI; PRK00051 1198676003815 The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731 1198676003816 Histidine biosynthesis protein; Region: His_biosynth; pfam00977 1198676003817 substrate binding site [chemical binding]; other site 1198676003818 glutamase interaction surface [polypeptide binding]; other site 1198676003819 HisA. Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1...; Region: HisA; cd04732 1198676003820 phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; Region: TIGR00007 1198676003821 catalytic residues [active] 1198676003822 imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13141 1198676003823 Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748 1198676003824 putative active site [active] 1198676003825 oxyanion strand; other site 1198676003826 catalytic triad [active] 1198676003827 Protein of unknown function (DUF2568); Region: DUF2568; pfam10823 1198676003828 Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cd07914 1198676003829 putative active site pocket [active] 1198676003830 4-fold oligomerization interface [polypeptide binding]; other site 1198676003831 metal binding residues [ion binding]; metal-binding site 1198676003832 3-fold/trimer interface [polypeptide binding]; other site 1198676003833 phosphoserine phosphatase SerB; Region: serB; TIGR00338 1198676003834 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1198676003835 motif II; other site 1198676003836 Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572 1198676003837 histidinol dehydrogenase; Region: hisD; TIGR00069 1198676003838 NAD binding site [chemical binding]; other site 1198676003839 dimerization interface [polypeptide binding]; other site 1198676003840 product binding site; other site 1198676003841 substrate binding site [chemical binding]; other site 1198676003842 zinc binding site [ion binding]; other site 1198676003843 catalytic residues [active] 1198676003844 ATP phosphoribosyltransferase catalytic subunit; Reviewed; Region: hisG; PRK01686 1198676003845 ATP phosphoribosyltransferase [Amino acid transport and metabolism]; Region: HisG; COG0040 1198676003846 ATP phosphoribosyltransferase, regulatory subunit; Region: hisZ_biosyn_reg; TIGR00443 1198676003847 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 1198676003848 dimer interface [polypeptide binding]; other site 1198676003849 motif 1; other site 1198676003850 active site 1198676003851 motif 2; other site 1198676003852 motif 3; other site 1198676003853 histidinol-phosphate aminotransferase; Region: hisC; TIGR01141 1198676003854 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1198676003855 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1198676003856 homodimer interface [polypeptide binding]; other site 1198676003857 catalytic residue [active] 1198676003858 septation ring formation regulator EzrA; Provisional; Region: PRK04778 1198676003859 DNA gyrase subunit B; Validated; Region: gyrB; PRK05644 1198676003860 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1198676003861 Mg2+ binding site [ion binding]; other site 1198676003862 G-X-G motif; other site 1198676003863 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 1198676003864 anchoring element; other site 1198676003865 dimer interface [polypeptide binding]; other site 1198676003866 ATP binding site [chemical binding]; other site 1198676003867 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 1198676003868 active site 1198676003869 putative metal-binding site [ion binding]; other site 1198676003870 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 1198676003871 Haloacid dehalogenase-like hydrolase; Region: HAD_2; pfam13419 1198676003872 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1198676003873 motif II; other site 1198676003874 Bacterial cell division membrane protein [Cell division and chromosome partitioning]; Region: FtsW; COG0772 1198676003875 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1198676003876 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1198676003877 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1198676003878 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1198676003879 NADH(P)-binding; Region: NAD_binding_10; pfam13460 1198676003880 NAD(P) binding site [chemical binding]; other site 1198676003881 active site 1198676003882 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1198676003883 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1198676003884 putative substrate translocation pore; other site 1198676003885 Helix-Turn-Helix DNA binding domain of GlnR-like transcription regulators; Region: HTH_GlnR-like; cd01105 1198676003886 DNA binding residues [nucleotide binding] 1198676003887 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 1198676003888 putative dimer interface [polypeptide binding]; other site 1198676003889 50S ribosomal protein L19; Provisional; Region: rplS; PRK05338 1198676003890 Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038 1198676003891 ClC sycA-like chloride channel proteins. This ClC family presents in bacteria, where it facilitates acid resistance in acidic soil. Mutation of this gene (sycA) in Rhizobium tropici CIAT899 causes serious deficiencies in nodule development, nodulation...; Region: ClC_sycA_like; cd03682 1198676003892 putative Cl- selectivity filter; other site 1198676003893 putative pore gating glutamate residue; other site 1198676003894 potential frameshift: common BLAST hit: gi|24379706|ref|NP_721661.1| chloride channel permease 1198676003895 hypothetical protein; Provisional; Region: PRK07248 1198676003896 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 1198676003897 cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814; cl03223 1198676003898 FeS assembly protein SufB; Region: sufB; TIGR01980 1198676003899 flavodoxin; Validated; Region: PRK07308 1198676003900 adenosine deaminase; Provisional; Region: PRK09358 1198676003901 active site 1198676003902 putative S-transferase; Provisional; Region: PRK11752 1198676003903 GST_N family, Ure2p-like subfamily; composed of the Saccharomyces cerevisiae Ure2p and related GSTs. Ure2p is a regulator for nitrogen catabolism in yeast. It represses the expression of several gene products involved in the use of poor nitrogen sources...; Region: GST_N_Ure2p_like; cd03048 1198676003904 C-terminal domain interface [polypeptide binding]; other site 1198676003905 GSH binding site (G-site) [chemical binding]; other site 1198676003906 dimer interface [polypeptide binding]; other site 1198676003907 C-terminal, alpha helical domain of Escherichia coli Yghu Glutathione S-transferases and related uncharacterized proteins; Region: GST_C_YghU_like; cd10292 1198676003908 dimer interface [polypeptide binding]; other site 1198676003909 N-terminal domain interface [polypeptide binding]; other site 1198676003910 active site 1198676003911 Exopolyphosphatase-related proteins [General function prediction only]; Region: COG0618 1198676003912 DHH family; Region: DHH; pfam01368 1198676003913 DHHA1 domain; Region: DHHA1; pfam02272 1198676003914 50S ribosomal protein L31 type B; Reviewed; Region: rpmE2; PRK01678 1198676003915 Cupin domain; Region: Cupin_2; cl17218 1198676003916 Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1917 1198676003917 Methyltransferase domain; Region: Methyltransf_31; pfam13847 1198676003918 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1198676003919 S-adenosylmethionine binding site [chemical binding]; other site 1198676003920 Metal binding protein AcdA. These proteins have been shown to function in the ABC uptake of Zn2+ and Mn2+ and in competence for genetic transformation and adhesion. The AcdA proteins belong to the TroA superfamily of helical backbone metal receptor...; Region: AdcA; cd01017 1198676003921 Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297 1198676003922 metal binding site [ion binding]; metal-binding site 1198676003923 YodA lipocalin-like domain; Region: YodA; pfam09223 1198676003924 Peptidase family C69; Region: Peptidase_C69; pfam03577 1198676003925 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1481 1198676003926 Sporulation Regulator WhiA N terminal; Region: WhiA_N; pfam10298 1198676003927 conserved hypothetical protein, cofD-related; Region: CofD_related; TIGR01826 1198676003928 Family of CofD-like proteins and proteins related to YvcK; Region: CofD_YvcK; cd07044 1198676003929 dimer interface [polypeptide binding]; other site 1198676003930 phosphate binding site [ion binding]; other site 1198676003931 glmZ(sRNA)-inactivating NTPase; Provisional; Region: PRK05416 1198676003932 Protein of unknown function (DUF1003); Region: DUF1003; pfam06210 1198676003933 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 1198676003934 homotrimer interaction site [polypeptide binding]; other site 1198676003935 putative active site [active] 1198676003936 Glycerol dehydrogenase and related enzymes [Energy production and conversion]; Region: GldA; COG0371 1198676003937 Glycerol dehydrogenase-like; Region: GlyDH-like2; cd08171 1198676003938 putative active site [active] 1198676003939 metal binding site [ion binding]; metal-binding site 1198676003940 asparaginyl-tRNA synthetase; Validated; Region: asnC; PRK03932 1198676003941 AsnRS_cyto_like_N: N-terminal, anticodon recognition domain of the type found in human and Saccharomyces cerevisiae cytoplasmic asparaginyl-tRNA synthetase (AsnRS), in Brugia malayai AsnRs and, in various putative bacterial AsnRSs. This domain is a...; Region: AsnRS_cyto_like_N; cd04323 1198676003942 putative dimer interface [polypeptide binding]; other site 1198676003943 putative anticodon binding site; other site 1198676003944 Asx tRNA synthetase (AspRS/AsnRS) class II core domain. Assignment to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs in the core domain. This family includes AsnRS as well as...; Region: AsxRS_core; cd00776 1198676003945 homodimer interface [polypeptide binding]; other site 1198676003946 motif 1; other site 1198676003947 motif 2; other site 1198676003948 active site 1198676003949 motif 3; other site 1198676003950 aspartate aminotransferase; Provisional; Region: PRK05764 1198676003951 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1198676003952 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1198676003953 homodimer interface [polypeptide binding]; other site 1198676003954 catalytic residue [active] 1198676003955 bifunctional ATP-dependent DNA helicase/DNA polymerase III subunit epsilon; Validated; Region: PRK07246 1198676003956 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 1198676003957 active site 1198676003958 catalytic site [active] 1198676003959 substrate binding site [chemical binding]; other site 1198676003960 DEAD/DEAH box helicase; Region: DEAD; pfam00270 1198676003961 Helicase C-terminal domain; Region: Helicase_C_2; pfam13307 1198676003962 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819 1198676003963 cytochrome c biogenesis protein CcmA; Provisional; Region: PRK13540 1198676003964 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cd00267 1198676003965 Walker A/P-loop; other site 1198676003966 ATP binding site [chemical binding]; other site 1198676003967 Q-loop/lid; other site 1198676003968 ABC transporter signature motif; other site 1198676003969 Walker B; other site 1198676003970 D-loop; other site 1198676003971 H-loop/switch region; other site 1198676003972 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4947 1198676003973 Putative esterase; Region: Esterase; pfam00756 1198676003974 ATP-grasp domain; Region: ATP-grasp_4; pfam13535 1198676003975 acetoin reductase; Validated; Region: PRK08643 1198676003976 meso-2,3-butanediol dehydrogenase-like, classical (c) SDRs; Region: meso-BDH-like_SDR_c; cd05366 1198676003977 NAD binding site [chemical binding]; other site 1198676003978 homotetramer interface [polypeptide binding]; other site 1198676003979 homodimer interface [polypeptide binding]; other site 1198676003980 active site 1198676003981 substrate binding site [chemical binding]; other site 1198676003982 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 1198676003983 Cell division protein [Cell division and chromosome partitioning]; Region: FtsX; COG2177 1198676003984 cell division ABC transporter subunit FtsX; Provisional; Region: ftsX; PRK11026 1198676003985 Predicted ATPase involved in cell division [Cell division and chromosome partitioning]; Region: FtsE; COG2884 1198676003986 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1198676003987 Walker A/P-loop; other site 1198676003988 ATP binding site [chemical binding]; other site 1198676003989 Q-loop/lid; other site 1198676003990 ABC transporter signature motif; other site 1198676003991 Walker B; other site 1198676003992 D-loop; other site 1198676003993 H-loop/switch region; other site 1198676003994 PCRF domain; Region: PCRF; pfam03462 1198676003995 Protein chain release factor B [Translation, ribosomal structure and biogenesis]; Region: PrfB; COG1186 1198676003996 RF-1 domain; Region: RF-1; pfam00472 1198676003997 epoxyqueuosine reductase; Region: TIGR00276 1198676003998 Domain of unknown function (DUF1730); Region: DUF1730; pfam08331 1198676003999 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 1198676004000 Transposase DDE domain; Region: DDE_Tnp_1_3; pfam13612 1198676004001 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 1198676004002 Transposase; Region: DDE_Tnp_ISL3; pfam01610 1198676004003 Helix-turn-helix domain of transposase family ISL3; Region: HTH_Tnp_ISL3; pfam13542 1198676004004 4'-phosphopantetheinyl transferase superfamily; Region: ACPS; pfam01648 1198676004005 putative enoyl-[acyl-carrier-protein] reductase II; Region: enACPred_II; TIGR03151 1198676004006 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 1198676004007 FMN binding site [chemical binding]; other site 1198676004008 substrate binding site [chemical binding]; other site 1198676004009 putative catalytic residue [active] 1198676004010 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 1198676004011 Acyl transferase domain; Region: Acyl_transf_1; cl08282 1198676004012 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1198676004013 methyl indole-3-acetate methyltransferase; Region: PLN02211; cl17657 1198676004014 H+ Antiporter protein; Region: 2A0121; TIGR00900 1198676004015 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1198676004016 putative substrate translocation pore; other site 1198676004017 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1198676004018 Condensation domain; Region: Condensation; pfam00668 1198676004019 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 1198676004020 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 1198676004021 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1198676004022 acyl-activating enzyme (AAE) consensus motif; other site 1198676004023 AMP binding site [chemical binding]; other site 1198676004024 active site 1198676004025 CoA binding site [chemical binding]; other site 1198676004026 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1198676004027 thioester reductase domain; Region: Thioester-redct; TIGR01746 1198676004028 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1198676004029 NAD(P) binding site [chemical binding]; other site 1198676004030 active site 1198676004031 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1198676004032 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1198676004033 Condensation domain; Region: Condensation; pfam00668 1198676004034 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 1198676004035 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 1198676004036 The adenylation domain of nonribosomal peptide synthetases (NRPS), including Streptoalloteichus tallysomycin biosynthesis genes; Region: A_NRPS_TlmIV_like; cd12114 1198676004037 acyl-activating enzyme (AAE) consensus motif; other site 1198676004038 AMP binding site [chemical binding]; other site 1198676004039 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1198676004040 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 1198676004041 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1198676004042 acyl-activating enzyme (AAE) consensus motif; other site 1198676004043 active site 1198676004044 AMP binding site [chemical binding]; other site 1198676004045 CoA binding site [chemical binding]; other site 1198676004046 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 1198676004047 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 1198676004048 acyl-activating enzyme (AAE) consensus motif; other site 1198676004049 AMP binding site [chemical binding]; other site 1198676004050 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1198676004051 Condensation domain; Region: Condensation; pfam00668 1198676004052 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 1198676004053 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 1198676004054 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 1198676004055 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 1198676004056 acyl-activating enzyme (AAE) consensus motif; other site 1198676004057 AMP binding site [chemical binding]; other site 1198676004058 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1198676004059 Condensation domain; Region: Condensation; pfam00668 1198676004060 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 1198676004061 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 1198676004062 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 1198676004063 acyl-activating enzyme (AAE) consensus motif; other site 1198676004064 AMP binding site [chemical binding]; other site 1198676004065 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1198676004066 Condensation domain; Region: Condensation; pfam00668 1198676004067 non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261 1198676004068 Condensation domain; Region: Condensation; pfam00668 1198676004069 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 1198676004070 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 1198676004071 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 1198676004072 active site 1198676004073 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1198676004074 Condensation domain; Region: Condensation; pfam00668 1198676004075 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 1198676004076 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 1198676004077 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 1198676004078 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1198676004079 acyl-activating enzyme (AAE) consensus motif; other site 1198676004080 AMP binding site [chemical binding]; other site 1198676004081 active site 1198676004082 CoA binding site [chemical binding]; other site 1198676004083 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1198676004084 Predicted thioesterase involved in non-ribosomal peptide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: GrsT; COG3208 1198676004085 potential frameshift: common BLAST hit: gi|24379774|ref|NP_721729.1| permease 1198676004086 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 1198676004087 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 1198676004088 Walker A/P-loop; other site 1198676004089 ATP binding site [chemical binding]; other site 1198676004090 Q-loop/lid; other site 1198676004091 ABC transporter signature motif; other site 1198676004092 Walker B; other site 1198676004093 D-loop; other site 1198676004094 H-loop/switch region; other site 1198676004095 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1198676004096 Transcriptional regulator C-terminal region; Region: TetR_C_8; pfam14278 1198676004097 HTH-like domain; Region: HTH_21; pfam13276 1198676004098 Integrase core domain; Region: rve; pfam00665 1198676004099 Integrase core domain; Region: rve_3; cl15866 1198676004100 HTH-like domain; Region: HTH_21; pfam13276 1198676004101 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1198676004102 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1198676004103 Transposase IS200 like; Region: Y1_Tnp; cl00848 1198676004104 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 1198676004105 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 1198676004106 FtsX-like permease family; Region: FtsX; pfam02687 1198676004107 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 1198676004108 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 1198676004109 FtsX-like permease family; Region: FtsX; pfam02687 1198676004110 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 1198676004111 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 1198676004112 Walker A/P-loop; other site 1198676004113 ATP binding site [chemical binding]; other site 1198676004114 Q-loop/lid; other site 1198676004115 ABC transporter signature motif; other site 1198676004116 Walker B; other site 1198676004117 D-loop; other site 1198676004118 H-loop/switch region; other site 1198676004119 Methyltransferase domain; Region: Methyltransf_31; pfam13847 1198676004120 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1198676004121 S-adenosylmethionine binding site [chemical binding]; other site 1198676004122 Integrase core domain; Region: rve; pfam00665 1198676004123 Integrase core domain; Region: rve_3; pfam13683 1198676004124 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 1198676004125 Transposase; Region: HTH_Tnp_1; cl17663 1198676004126 Helix-turn-helix domain; Region: HTH_28; pfam13518 1198676004127 Helix-turn-helix domain; Region: HTH_28; pfam13518 1198676004128 Uncharacterized protein family (UPF0157); Region: UPF0157; pfam04229 1198676004129 Telomere recombination; Region: Sua5_yciO_yrdC; cl00305 1198676004130 Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily; Region: PI-PLCc_GDPD_SF; cl14615 1198676004131 active site 1198676004132 isopropylmalate isomerase small subunit; Provisional; Region: leuD; PRK01641 1198676004133 Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577 1198676004134 substrate binding site [chemical binding]; other site 1198676004135 3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402 1198676004136 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583 1198676004137 substrate binding site [chemical binding]; other site 1198676004138 ligand binding site [chemical binding]; other site 1198676004139 3-isopropylmalate dehydrogenase; Provisional; Region: PRK00772 1198676004140 tartrate dehydrogenase; Region: TTC; TIGR02089 1198676004141 2-isopropylmalate synthase; Validated; Region: PRK00915 1198676004142 2-isopropylmalate synthase (IPMS), N-terminal catalytic TIM barrel domain; Region: DRE_TIM_IPMS; cd07940 1198676004143 active site 1198676004144 catalytic residues [active] 1198676004145 metal binding site [ion binding]; metal-binding site 1198676004146 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; pfam08502 1198676004147 Uridine kinase [Nucleotide transport and metabolism]; Region: Udk; COG0572 1198676004148 Uridine monophosphate kinase (UMPK, EC 2.7.1.48), also known as uridine kinase or uridine-cytidine kinase (UCK), catalyzes the reversible phosphoryl transfer from ATP to uridine or cytidine to yield UMP or CMP. In the primidine nucleotide-salvage pathway; Region: UMPK; cd02023 1198676004149 Sugar specificity; other site 1198676004150 Pyrimidine base specificity; other site 1198676004151 ATP-binding site [chemical binding]; other site 1198676004152 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 1198676004153 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 1198676004154 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 1198676004155 DEAD-like helicases superfamily; Region: DEXDc; smart00487 1198676004156 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 1198676004157 ATP binding site [chemical binding]; other site 1198676004158 putative Mg++ binding site [ion binding]; other site 1198676004159 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1198676004160 nucleotide binding region [chemical binding]; other site 1198676004161 ATP-binding site [chemical binding]; other site 1198676004162 Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and...; Region: PEPCK_HprK; cl00270 1198676004163 active site 1198676004164 metal-binding site [ion binding] 1198676004165 active site 1198676004166 nucleotide-binding site [chemical binding]; other site 1198676004167 nucleotide-binding site [chemical binding]; other site 1198676004168 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 1198676004169 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1198676004170 Coenzyme A binding pocket [chemical binding]; other site 1198676004171 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1198676004172 GTP-binding protein LepA; Provisional; Region: PRK05433 1198676004173 LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890 1198676004174 G1 box; other site 1198676004175 putative GEF interaction site [polypeptide binding]; other site 1198676004176 GTP/Mg2+ binding site [chemical binding]; other site 1198676004177 Switch I region; other site 1198676004178 G2 box; other site 1198676004179 G3 box; other site 1198676004180 Switch II region; other site 1198676004181 G4 box; other site 1198676004182 G5 box; other site 1198676004183 lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699 1198676004184 lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane. LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709 1198676004185 GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421 1198676004186 potential frameshift: common BLAST hit: gi|387785890|ref|YP_006250986.1| Glucan-binding protein C 1198676004187 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1198676004188 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1198676004189 non-specific DNA binding site [nucleotide binding]; other site 1198676004190 salt bridge; other site 1198676004191 sequence-specific DNA binding site [nucleotide binding]; other site 1198676004192 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1198676004193 non-specific DNA binding site [nucleotide binding]; other site 1198676004194 salt bridge; other site 1198676004195 sequence-specific DNA binding site [nucleotide binding]; other site 1198676004196 Predicted transcriptional regulator [Transcription]; Region: COG2932 1198676004197 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 1198676004198 Catalytic site [active] 1198676004199 Uncharacterized protein family (UPF0150); Region: UPF0150; pfam03681 1198676004200 YcfA-like protein; Region: YcfA; pfam07927 1198676004201 CRISPR/Cas system-associated protein Csn2; Region: Csn2; cd09758 1198676004202 CRISPR type II-A/NMEMI-associated protein Csn2; Region: cas_Csn2; TIGR01866 1198676004203 tetramer interface [polypeptide binding]; other site 1198676004204 putative DNA binding site [nucleotide binding]; other site 1198676004205 Ca binding site [ion binding]; other site 1198676004206 Ca binding site [ion binding]; other site 1198676004207 CRISPR/Cas system-associated protein Cas2; Region: Cas2_I_II_III; cd09638 1198676004208 CRISPR/Cas system-associated protein Cas1; Region: Cas1_II; cd09720 1198676004209 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cl00083 1198676004210 CRISPR/Cas system-associated protein Cas9; Region: Csn1; cd09643 1198676004211 Predicted flavoprotein [General function prediction only]; Region: COG0431 1198676004212 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 1198676004213 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1198676004214 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1198676004215 hypothetical protein; Validated; Region: PRK07121 1198676004216 Predicted oxidoreductase [General function prediction only]; Region: COG3573 1198676004217 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1198676004218 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1198676004219 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 1198676004220 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 1198676004221 Walker A/P-loop; other site 1198676004222 ATP binding site [chemical binding]; other site 1198676004223 Q-loop/lid; other site 1198676004224 ABC transporter signature motif; other site 1198676004225 Walker B; other site 1198676004226 D-loop; other site 1198676004227 H-loop/switch region; other site 1198676004228 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 1198676004229 FtsX-like permease family; Region: FtsX; pfam02687 1198676004230 HAD-superfamily subfamily IIA hydrolase, TIGR01457; Region: HAD-SF-IIA-hyp2 1198676004231 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1198676004232 active site 1198676004233 motif I; other site 1198676004234 motif II; other site 1198676004235 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1198676004236 Hydrolase of X-linked nucleoside diphosphate N terminal; Region: Nudix_N; pfam12535 1198676004237 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_14; cd04672 1198676004238 nudix motif; other site 1198676004239 Acyl-ACP thioesterase; Region: Acyl-ACP_TE; pfam01643 1198676004240 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 1198676004241 active site 1198676004242 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 1198676004243 active site 2 [active] 1198676004244 coproporphyrinogen III oxidase; Provisional; Region: PRK08599 1198676004245 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1198676004246 FeS/SAM binding site; other site 1198676004247 HemN C-terminal domain; Region: HemN_C; pfam06969 1198676004248 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1198676004249 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1198676004250 WHG domain; Region: WHG; pfam13305 1198676004251 Putative NADPH-quinone reductase (modulator of drug activity B) [General function prediction only]; Region: MdaB; COG2249 1198676004252 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 1198676004253 branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856 1198676004254 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 1198676004255 E3 interaction surface; other site 1198676004256 lipoyl attachment site [posttranslational modification]; other site 1198676004257 e3 binding domain; Region: E3_binding; pfam02817 1198676004258 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 1198676004259 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 1198676004260 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 1198676004261 alpha subunit interface [polypeptide binding]; other site 1198676004262 TPP binding site [chemical binding]; other site 1198676004263 heterodimer interface [polypeptide binding]; other site 1198676004264 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 1198676004265 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, alpha subunit [Energy production and conversion]; Region: AcoA; COG1071 1198676004266 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 1198676004267 tetramer interface [polypeptide binding]; other site 1198676004268 TPP-binding site [chemical binding]; other site 1198676004269 heterodimer interface [polypeptide binding]; other site 1198676004270 phosphorylation loop region [posttranslational modification] 1198676004271 dihydrolipoamide dehydrogenase; Region: lipoamide_DH; TIGR01350 1198676004272 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1198676004273 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 1198676004274 ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346 1198676004275 Clp amino terminal domain; Region: Clp_N; pfam02861 1198676004276 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1198676004277 Walker A motif; other site 1198676004278 ATP binding site [chemical binding]; other site 1198676004279 Walker B motif; other site 1198676004280 arginine finger; other site 1198676004281 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1198676004282 Walker A motif; other site 1198676004283 ATP binding site [chemical binding]; other site 1198676004284 Walker B motif; other site 1198676004285 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 1198676004286 phosphoglucosamine mutase; Provisional; Region: glmM; PRK14316 1198676004287 GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802 1198676004288 active site 1198676004289 substrate binding site [chemical binding]; other site 1198676004290 metal binding site [ion binding]; metal-binding site 1198676004291 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4856 1198676004292 YbbR-like protein; Region: YbbR; pfam07949 1198676004293 YbbR-like protein; Region: YbbR; pfam07949 1198676004294 Uncharacterized conserved protein [Function unknown]; Region: COG1624 1198676004295 DisA bacterial checkpoint controller nucleotide-binding; Region: DisA_N; pfam02457 1198676004296 UDP-N-acetylmuramyl tripeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurE; COG0769 1198676004297 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 1198676004298 Domain of unknown function (DUF1727); Region: DUF1727; pfam08353 1198676004299 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyric Acid Synthase (CobQ); Region: GATase1_CobQ; cd01750 1198676004300 catalytic triad [active] 1198676004301 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 1198676004302 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1198676004303 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1198676004304 ABC transporter; Region: ABC_tran_2; pfam12848 1198676004305 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1198676004306 ABC transporter; Region: ABC_tran_2; pfam12848 1198676004307 Glycosyl hydrolases family 8; Region: Glyco_hydro_8; cl01351 1198676004308 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 1198676004309 CESA_like is the cellulose synthase superfamily; Region: CESA_like; cd06423 1198676004310 DXD motif; other site 1198676004311 Protein gp23 (Bacteriophage A118); Region: Phage_Gp23; pfam10669 1198676004312 UDP-N-acetylglucosamine 2-epimerase [Cell envelope biogenesis, outer membrane]; Region: WecB; COG0381 1198676004313 Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786 1198676004314 active site 1198676004315 homodimer interface [polypeptide binding]; other site 1198676004316 Zinc-dependent metalloprotease, MMP_like subfamily. This group contains matrix metalloproteinases (MMPs), serralysins, and the astacin_like family of proteases; Region: ZnMc_MMP_like; cd04268 1198676004317 active site 1198676004318 Protein of unknown function (DUF1307); Region: DUF1307; pfam06998 1198676004319 S-formylglutathione hydrolase; Region: PLN02442 1198676004320 Predicted esterase [General function prediction only]; Region: COG0627 1198676004321 Zinc finger domain containing protein (CHY type) [Function unknown]; Region: COG4357 1198676004322 CHY zinc finger; Region: zf-CHY; pfam05495 1198676004323 mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595 1198676004324 Metallo-beta-lactamase superfamily; Region: Lactamase_B; pfam00753 1198676004325 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 1198676004326 ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: PhnK; COG1101 1198676004327 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1198676004328 Walker A/P-loop; other site 1198676004329 ATP binding site [chemical binding]; other site 1198676004330 Q-loop/lid; other site 1198676004331 ABC transporter signature motif; other site 1198676004332 Walker B; other site 1198676004333 D-loop; other site 1198676004334 H-loop/switch region; other site 1198676004335 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 1198676004336 Transmembrane subunit (TM) of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which are involved in the uptake of branched-chain amino acids (AAs), as well as TMs of transporters involved in the uptake of...; Region: TM_PBP1_branched-chain-AA_like; cd06574 1198676004337 TM-ABC transporter signature motif; other site 1198676004338 Type I periplasmic ligand-binding domain of uncharacterized ABC-type transport systems that are predicted to be involved in the uptake of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_uncharacterized_transporter; cd06325 1198676004339 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 1198676004340 zinc binding site [ion binding]; other site 1198676004341 putative ligand binding site [chemical binding]; other site 1198676004342 Fibronectin-binding protein A N-terminus (FbpA); Region: FbpA; pfam05833 1198676004343 Domain of unknown function (DUF814); Region: DUF814; pfam05670 1198676004344 potential frameshift: common BLAST hit: gi|387785844|ref|YP_006250940.1| putative amino acid permease 1198676004345 Alpha-acetolactate decarboxylase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: AlsD; COG3527 1198676004346 acetolactate synthase; Reviewed; Region: PRK08617 1198676004347 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 1198676004348 PYR/PP interface [polypeptide binding]; other site 1198676004349 dimer interface [polypeptide binding]; other site 1198676004350 TPP binding site [chemical binding]; other site 1198676004351 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 1198676004352 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629 1198676004353 TPP-binding site [chemical binding]; other site 1198676004354 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1198676004355 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1198676004356 binding surface 1198676004357 TPR motif; other site 1198676004358 Anaphase-promoting complex, cyclosome, subunit 3; Region: Apc3; pfam12895 1198676004359 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 1198676004360 binding surface 1198676004361 TPR motif; other site 1198676004362 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 1198676004363 Domain of unknown function DUF20; Region: UPF0118; pfam01594 1198676004364 MutT homolog-1 (MTH1) is a member of the Nudix hydrolase superfamily. MTH1, the mammalian counterpart of MutT, hydrolyzes oxidized purine nucleoside triphosphates, such as 8-oxo-dGTP and 2-hydroxy-ATP, to monophosphates, thereby preventing the...; Region: MTH1; cd03427 1198676004365 putative active site [active] 1198676004366 nucleotide binding site [chemical binding]; other site 1198676004367 nudix motif; other site 1198676004368 putative metal binding site [ion binding]; other site 1198676004369 dTDP-D-glucose 4,6-dehydratase [Cell envelope biogenesis, outer membrane]; Region: RfbB; COG1088 1198676004370 dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246 1198676004371 NAD binding site [chemical binding]; other site 1198676004372 substrate binding site [chemical binding]; other site 1198676004373 homodimer interface [polypeptide binding]; other site 1198676004374 active site 1198676004375 dTDP-4-dehydrorhamnose 3,5-epimerase and related enzymes [Cell envelope biogenesis, outer membrane]; Region: RfbC; COG1898 1198676004376 G1P_TT_short is the short form of glucose-1-phosphate thymidylyltransferase; Region: G1P_TT_short; cd02538 1198676004377 glucose-1-phosphate thymidylyltransferase, short form; Region: rmlA; TIGR01207 1198676004378 substrate binding site; other site 1198676004379 tetramer interface; other site 1198676004380 Uncharacterized conserved protein [Function unknown]; Region: COG0327 1198676004381 NIF3 (NGG1p interacting factor 3); Region: NIF3; pfam01784 1198676004382 Predicted SAM-dependent methyltransferase [General function prediction only]; Region: COG2384 1198676004383 Family of unknown function (DUF633); Region: DUF633; pfam04816 1198676004384 Putative primosome component and related proteins [DNA replication, recombination, and repair]; Region: DnaD; COG3935 1198676004385 Replication initiation and membrane attachment; Region: DnaB_2; pfam07261 1198676004386 Homoserine O-succinyltransferase; Region: HTS; pfam04204 1198676004387 Type 1 glutamine amidotransferase (GATase1)-like domain found in homoserine trans-succinylase (HTS); Region: GATase1_HTS; cd03131 1198676004388 proposed active site lysine [active] 1198676004389 conserved cys residue [active] 1198676004390 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1198676004391 active site 1198676004392 Protein of unknown function (DUF1706); Region: DUF1706; cl01748 1198676004393 Protein of unknown function (DUF1706); Region: DUF1706; cl01748 1198676004394 GyrI-like small molecule binding domain; Region: GyrI-like; cl01368 1198676004395 Predicted transcriptional regulator [Transcription]; Region: COG2378 1198676004396 HTH domain; Region: HTH_11; pfam08279 1198676004397 WYL domain; Region: WYL; pfam13280 1198676004398 single-stranded-DNA-specific exonuclease RecJ; Region: recJ; TIGR00644 1198676004399 DHH family; Region: DHH; pfam01368 1198676004400 Single-strand DNA-specific exonuclease, C terminal domain; Region: ssDNA-exonuc_C; pfam10141 1198676004401 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 1198676004402 classical (c) SDRs; Region: SDR_c; cd05233 1198676004403 NAD(P) binding site [chemical binding]; other site 1198676004404 active site 1198676004405 ribonuclease Z; Region: RNase_Z; TIGR02651 1198676004406 Galactose-1-phosphate uridyl transferase, N-terminal domain; Region: GalP_UDP_transf; pfam01087 1198676004407 GTP-binding protein HflX; Region: GTP_HflX; TIGR03156 1198676004408 GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167 1198676004409 HflX GTPase family; Region: HflX; cd01878 1198676004410 G1 box; other site 1198676004411 GTP/Mg2+ binding site [chemical binding]; other site 1198676004412 Switch I region; other site 1198676004413 G2 box; other site 1198676004414 G3 box; other site 1198676004415 Switch II region; other site 1198676004416 G4 box; other site 1198676004417 G5 box; other site 1198676004418 tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091 1198676004419 tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324 1198676004420 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1198676004421 Predicted acetyltransferase [General function prediction only]; Region: COG3981 1198676004422 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 1198676004423 Uncharacterized conserved protein [Function unknown]; Region: COG1479 1198676004424 Protein of unknown function DUF262; Region: DUF262; pfam03235 1198676004425 Protein of unknown function DUF262; Region: DUF262; pfam03235 1198676004426 Protein of unknown function (DUF1524); Region: DUF1524; pfam07510 1198676004427 hypothetical protein; Provisional; Region: PRK07329 1198676004428 Polymerase and Histidinol Phosphatase domain; Region: PHP; cl17102 1198676004429 active site 1198676004430 CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311 1198676004431 substrate binding site [chemical binding]; other site 1198676004432 THF binding site; other site 1198676004433 zinc-binding site [ion binding]; other site 1198676004434 Protein of unknown function (DUF3884); Region: DUF3884; pfam13024 1198676004435 Aldose 1-epimerase, similar to Lactococcus lactis lacX; Region: Aldose_epim_lacX; cd09024 1198676004436 active site 1198676004437 catalytic residues [active] 1198676004438 6-phospho-beta-galactosidase; Provisional; Region: PRK13511 1198676004439 beta-galactosidase; Region: BGL; TIGR03356 1198676004440 phosphotransferase system, lactose specific, IIC component; Region: lac_pts_IIC; TIGR00394 1198676004441 Phosphotransferase system, EIIC; Region: PTS_EIIC; pfam02378 1198676004442 PTS_IIB: subunit IIB of enzyme II (EII) is the central energy-coupling domain of the phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In the multienzyme PTS complex, EII is a carbohydrate-specific permease consisting of two cytoplasmic...; Region: PTS_IIB; cl10014 1198676004443 active site 1198676004444 P-loop; other site 1198676004445 phosphorylation site [posttranslational modification] 1198676004446 PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_lac; cd00215 1198676004447 active site 1198676004448 methionine cluster; other site 1198676004449 phosphorylation site [posttranslational modification] 1198676004450 metal binding site [ion binding]; metal-binding site 1198676004451 tagatose 1,6-diphosphate aldolase; Reviewed; Region: PRK12399 1198676004452 1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164 1198676004453 tagatose-6-phosphate kinase; Region: lacC; TIGR01231 1198676004454 putative substrate binding site [chemical binding]; other site 1198676004455 putative ATP binding site [chemical binding]; other site 1198676004456 galactose-6-phosphate isomerase subunit LacB; Reviewed; Region: PRK08622 1198676004457 galactose-6-phosphate isomerase subunit LacA; Reviewed; Region: PRK08621 1198676004458 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 1198676004459 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; pfam08220 1198676004460 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 1198676004461 helicase-exonuclease AddAB, AddA subunit, Firmicutes type; Region: addA_Gpos; TIGR02785 1198676004462 Family description; Region: UvrD_C_2; pfam13538 1198676004463 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 1198676004464 ATP-dependent nuclease subunit B; Region: rexB_recomb; TIGR02774 1198676004465 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 1198676004466 CRISPR/Cas system-associated protein Cas2; Region: Cas2_I-E; cd09755 1198676004467 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 1198676004468 active site 1198676004469 catalytic site [active] 1198676004470 substrate binding site [chemical binding]; other site 1198676004471 CRISPR/Cas system-associated protein Cas1; Region: Cas1_I-E; cd09719 1198676004472 CRISPR/Cas system-associated RAMP superfamily protein Cas6e; Region: Cas6_I-E; cd09727 1198676004473 CRISPR-associated protein (Cas_Cas5); Region: Cas_Cas5d; pfam09704 1198676004474 CRISPR/Cas system-associated RAMP superfamily protein Cas5; Region: Cas5_I-E; cd09756 1198676004475 CRISPR/Cas system-associated RAMP superfamily protein Cas7; Region: Cas7_I-E; cl09608 1198676004476 CRISPR/Cas system-associated protein Cse2; Region: Cse2_I-E; cd09731 1198676004477 potential frameshift: common BLAST hit: gi|387761331|ref|YP_006068308.1| CRISPR system CASCADE complex protein CasA 1198676004478 helicase Cas3; Provisional; Region: PRK09694 1198676004479 CRISPR/Cas system-associated protein Cas3'' Region: Cas3''_I; cd09641 1198676004480 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 1198676004481 WYL domain; Region: WYL; pfam13280 1198676004482 Sugar efflux transporter for intercellular exchange; Region: MtN3_slv; pfam03083 1198676004483 Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; smart00896 1198676004484 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 1198676004485 putative efflux protein, MATE family; Region: matE; TIGR00797 1198676004486 putative heme d1 biosynthesis radical SAM protein NirJ1; Region: rSAM_NirJ1; TIGR04054 1198676004487 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1198676004488 FeS/SAM binding site; other site 1198676004489 radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085 1198676004490 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1198676004491 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1198676004492 non-specific DNA binding site [nucleotide binding]; other site 1198676004493 salt bridge; other site 1198676004494 sequence-specific DNA binding site [nucleotide binding]; other site 1198676004495 transcriptional activator, Rgg/GadR/MutR family, C-terminal domain; Region: RGG_Cterm; TIGR01716 1198676004496 phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629 1198676004497 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 1198676004498 putative tRNA-binding site [nucleotide binding]; other site 1198676004499 B3/4 domain; Region: B3_4; pfam03483 1198676004500 tRNA synthetase B5 domain; Region: B5; smart00874 1198676004501 Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA, PheRS is an...; Region: PheRS_beta_core; cd00769 1198676004502 dimer interface [polypeptide binding]; other site 1198676004503 motif 1; other site 1198676004504 motif 3; other site 1198676004505 motif 2; other site 1198676004506 Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; pfam03147 1198676004507 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 1198676004508 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1198676004509 Coenzyme A binding pocket [chemical binding]; other site 1198676004510 phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488 1198676004511 Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912 1198676004512 Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496 1198676004513 dimer interface [polypeptide binding]; other site 1198676004514 motif 1; other site 1198676004515 active site 1198676004516 motif 2; other site 1198676004517 motif 3; other site 1198676004518 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 1198676004519 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 1198676004520 Walker A/P-loop; other site 1198676004521 ATP binding site [chemical binding]; other site 1198676004522 Q-loop/lid; other site 1198676004523 SMC proteins Flexible Hinge Domain; Region: SMC_hinge; smart00968 1198676004524 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 1198676004525 ABC transporter signature motif; other site 1198676004526 Walker B; other site 1198676004527 D-loop; other site 1198676004528 H-loop/switch region; other site 1198676004529 ribonuclease III; Reviewed; Region: rnc; PRK00102 1198676004530 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 1198676004531 dimerization interface [polypeptide binding]; other site 1198676004532 active site 1198676004533 metal binding site [ion binding]; metal-binding site 1198676004534 Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048 1198676004535 dsRNA binding site [nucleotide binding]; other site 1198676004536 Metal-dependent hydrolases of the beta-lactamase superfamily I [General function prediction only]; Region: PhnP; COG1235 1198676004537 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 1198676004538 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 1198676004539 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1198676004540 putative active site [active] 1198676004541 heme pocket [chemical binding]; other site 1198676004542 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1198676004543 dimer interface [polypeptide binding]; other site 1198676004544 phosphorylation site [posttranslational modification] 1198676004545 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1198676004546 ATP binding site [chemical binding]; other site 1198676004547 Mg2+ binding site [ion binding]; other site 1198676004548 G-X-G motif; other site 1198676004549 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1198676004550 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1198676004551 active site 1198676004552 phosphorylation site [posttranslational modification] 1198676004553 intermolecular recognition site; other site 1198676004554 dimerization interface [polypeptide binding]; other site 1198676004555 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1198676004556 DNA binding site [nucleotide binding] 1198676004557 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 1198676004558 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 1198676004559 Walker A/P-loop; other site 1198676004560 ATP binding site [chemical binding]; other site 1198676004561 Q-loop/lid; other site 1198676004562 ABC transporter signature motif; other site 1198676004563 Walker B; other site 1198676004564 D-loop; other site 1198676004565 H-loop/switch region; other site 1198676004566 bifunctional adhesin/ABC transporter aspartate/glutamate-binding protein; Reviewed; Region: PRK11917 1198676004567 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1198676004568 substrate binding pocket [chemical binding]; other site 1198676004569 membrane-bound complex binding site; other site 1198676004570 hinge residues; other site 1198676004571 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1198676004572 dimer interface [polypeptide binding]; other site 1198676004573 conserved gate region; other site 1198676004574 putative PBP binding loops; other site 1198676004575 ABC-ATPase subunit interface; other site 1198676004576 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1198676004577 dimer interface [polypeptide binding]; other site 1198676004578 conserved gate region; other site 1198676004579 putative PBP binding loops; other site 1198676004580 ABC-ATPase subunit interface; other site 1198676004581 DNA/RNA non-specific endonuclease; Region: Endonuclease_NS; smart00892 1198676004582 DNA/RNA non-specific endonuclease; Region: Endonuclea_NS_2; cl17626 1198676004583 DNA-directed RNA polymerase subunit beta; Region: EpuA; pfam11772 1198676004584 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 1198676004585 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 1198676004586 hinge; other site 1198676004587 active site 1198676004588 Protein of unknown function (DUF1146); Region: DUF1146; cl11486 1198676004589 F0F1 ATP synthase subunit epsilon; Validated; Region: atpC; PRK00571 1198676004590 mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152 1198676004591 gamma subunit interface [polypeptide binding]; other site 1198676004592 epsilon subunit interface [polypeptide binding]; other site 1198676004593 LBP interface [polypeptide binding]; other site 1198676004594 F0F1 ATP synthase subunit beta; Validated; Region: PRK09280 1198676004595 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 1198676004596 F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133 1198676004597 alpha subunit interaction interface [polypeptide binding]; other site 1198676004598 Walker A motif; other site 1198676004599 ATP binding site [chemical binding]; other site 1198676004600 Walker B motif; other site 1198676004601 inhibitor binding site; inhibition site 1198676004602 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 1198676004603 mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151 1198676004604 core domain interface [polypeptide binding]; other site 1198676004605 delta subunit interface [polypeptide binding]; other site 1198676004606 epsilon subunit interface [polypeptide binding]; other site 1198676004607 F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281 1198676004608 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 1198676004609 F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132 1198676004610 beta subunit interaction interface [polypeptide binding]; other site 1198676004611 Walker A motif; other site 1198676004612 ATP binding site [chemical binding]; other site 1198676004613 Walker B motif; other site 1198676004614 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 1198676004615 F0F1 ATP synthase subunit delta; Validated; Region: PRK05758 1198676004616 ATP synthase delta (OSCP) subunit; Region: OSCP; pfam00213 1198676004617 F0F1-type ATP synthase, subunit b [Energy production and conversion]; Region: AtpF; COG0711 1198676004618 ATP synthase, F0 subunit b; Region: ATP_synt_b; TIGR01144 1198676004619 F0F1 ATP synthase subunit A; Validated; Region: PRK05815 1198676004620 F0F1-type ATP synthase, subunit a [Energy production and conversion]; Region: AtpB; COG0356 1198676004621 F0F1 ATP synthase subunit C; Provisional; Region: PRK13467 1198676004622 This is a family of oligosaccharide phosphorylases. It includes yeast and mammalian glycogen phosphorylases, plant starch/glucan phosphorylase, as well as the maltodextrin phosphorylases of bacteria. The members of this family catalyze the breakdown of...; Region: GT1_Glycogen_Phosphorylase; cd04300 1198676004623 homodimer interface [polypeptide binding]; other site 1198676004624 glycogen/starch/alpha-glucan phosphorylases; Region: P_ylase; TIGR02093 1198676004625 active site pocket [active] 1198676004626 glycogen synthase; Provisional; Region: glgA; PRK00654 1198676004627 This family is most closely related to the GT1 family of glycosyltransferases. Glycogen synthase catalyzes the formation and elongation of the alpha-1,4-glucose backbone using ADP-glucose, the second and key step of glycogen biosynthesis. This family...; Region: GT1_Glycogen_synthase_DULL1_like; cd03791 1198676004628 ADP-binding pocket [chemical binding]; other site 1198676004629 homodimer interface [polypeptide binding]; other site 1198676004630 glucose-1-phosphate adenylyltransferase, GlgD subunit; Region: glgD; TIGR02092 1198676004631 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 1198676004632 active site 1198676004633 Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651 1198676004634 dimer interface [polypeptide binding]; other site 1198676004635 N-terminal domain interface [polypeptide binding]; other site 1198676004636 sulfate 1 binding site; other site 1198676004637 glucose-1-phosphate adenylyltransferase; Provisional; Region: glgC; PRK05293 1198676004638 ADP-glucose pyrophosphorylase is involved in the biosynthesis of glycogen or starch; Region: ADP_Glucose_PP; cd02508 1198676004639 ligand binding site; other site 1198676004640 oligomer interface; other site 1198676004641 Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651 1198676004642 dimer interface [polypeptide binding]; other site 1198676004643 N-terminal domain interface [polypeptide binding]; other site 1198676004644 sulfate 1 binding site; other site 1198676004645 glycogen branching enzyme; Provisional; Region: PRK12313 1198676004646 N-terminal Early set domain associated with the catalytic domain of prokaryotic glycogen branching enzyme; Region: E_set_GBE_prok_N; cd02855 1198676004647 Alpha amylase catalytic domain found in the Glycogen branching enzyme (also called 1,4-alpha-glucan branching enzyme); Region: AmyAc_Glg_BE; cd11322 1198676004648 active site 1198676004649 catalytic site [active] 1198676004650 Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; pfam02806 1198676004651 Family 41 Carbohydrate-Binding Module from pullulanase-like enzymes; Region: CBM41_pullulanase; cd10315 1198676004652 carbohydrate binding site [chemical binding]; other site 1198676004653 pullulanase, type I; Region: pulA_typeI; TIGR02104 1198676004654 Early set domain associated with the catalytic domain of pullulanase (also called dextrinase and alpha-dextrin endo-1,6-alpha glucosidase); Region: E_set_Pullulanase; cd02860 1198676004655 Alpha amylase catalytic domain found in Pullulanase (also called dextrinase; alpha-dextrin endo-1,6-alpha glucosidase), limit dextrinase, and related proteins; Region: AmyAc_Pullulanase_LD-like; cd11341 1198676004656 Ca binding site [ion binding]; other site 1198676004657 active site 1198676004658 catalytic site [active] 1198676004659 putative lipid kinase; Reviewed; Region: PRK13055 1198676004660 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 1198676004661 NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956 1198676004662 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114 1198676004663 nucleotide binding pocket [chemical binding]; other site 1198676004664 K-X-D-G motif; other site 1198676004665 catalytic site [active] 1198676004666 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 1198676004667 NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119 1198676004668 Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027 1198676004669 Dimer interface [polypeptide binding]; other site 1198676004670 BRCT sequence motif; other site 1198676004671 Predicted membrane protein [Function unknown]; Region: COG4708 1198676004672 Predicted membrane protein [Function unknown]; Region: COG2246 1198676004673 GtrA-like protein; Region: GtrA; pfam04138 1198676004674 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1198676004675 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1198676004676 active site 1198676004677 phosphorylation site [posttranslational modification] 1198676004678 intermolecular recognition site; other site 1198676004679 dimerization interface [polypeptide binding]; other site 1198676004680 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1198676004681 DNA binding residues [nucleotide binding] 1198676004682 dimerization interface [polypeptide binding]; other site 1198676004683 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 1198676004684 Histidine kinase; Region: HisKA_3; pfam07730 1198676004685 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1198676004686 ATP binding site [chemical binding]; other site 1198676004687 Mg2+ binding site [ion binding]; other site 1198676004688 G-X-G motif; other site 1198676004689 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 1198676004690 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 1198676004691 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 1198676004692 Walker A/P-loop; other site 1198676004693 ATP binding site [chemical binding]; other site 1198676004694 Q-loop/lid; other site 1198676004695 ABC transporter signature motif; other site 1198676004696 Walker B; other site 1198676004697 D-loop; other site 1198676004698 H-loop/switch region; other site 1198676004699 EXLDI protein; Region: EXLDI; TIGR04342 1198676004700 Ribonuclease BN family enzyme [Replication, recombination, and repair]; Region: Rbn; COG1295 1198676004701 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 1198676004702 active site 1198676004703 Predicted transcriptional regulator containing CBS domains [Transcription]; Region: COG4109 1198676004704 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1198676004705 DNA-binding site [nucleotide binding]; DNA binding site 1198676004706 DRTGG domain; Region: DRTGG; pfam07085 1198676004707 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with a DRTGG domain upstream. The function of the DRTGG domain, named after its conserved residues, is unknown. CBS is a small domain originally...; Region: CBS_pair_DRTGG_assoc; cd04596 1198676004708 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 1198676004709 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 1198676004710 Predicted membrane protein [Function unknown]; Region: COG2510 1198676004711 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 1198676004712 TrkA-N domain; Region: TrkA_N; pfam02254 1198676004713 TrkA-C domain; Region: TrkA_C; pfam02080 1198676004714 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 1198676004715 TrkA-N domain; Region: TrkA_N; pfam02254 1198676004716 TrkA-C domain; Region: TrkA_C; pfam02080 1198676004717 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 1198676004718 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; pfam00690 1198676004719 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 1198676004720 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 1198676004721 Soluble P-type ATPase [General function prediction only]; Region: COG4087 1198676004722 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 1198676004723 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 1198676004724 glycogen/starch/alpha-glucan phosphorylases; Region: P_ylase; TIGR02093 1198676004725 4-alpha-glucanotransferase; Provisional; Region: PRK14508 1198676004726 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1198676004727 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1198676004728 DNA binding site [nucleotide binding] 1198676004729 domain linker motif; other site 1198676004730 Ligand-binding domain of uncharacterized transcription regulator ycjW which is a member of the LacI-GalR family repressors; Region: PBP1_ycjW_transcription_regulator_like; cd06294 1198676004731 putative dimerization interface [polypeptide binding]; other site 1198676004732 putative ligand binding site [chemical binding]; other site 1198676004733 Maltose-binding periplasmic proteins/domains [Carbohydrate transport and metabolism]; Region: MalE; COG2182 1198676004734 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 1198676004735 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1198676004736 dimer interface [polypeptide binding]; other site 1198676004737 conserved gate region; other site 1198676004738 ABC-ATPase subunit interface; other site 1198676004739 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 1198676004740 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1198676004741 dimer interface [polypeptide binding]; other site 1198676004742 conserved gate region; other site 1198676004743 putative PBP binding loops; other site 1198676004744 ABC-ATPase subunit interface; other site 1198676004745 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 1198676004746 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 1198676004747 Walker A/P-loop; other site 1198676004748 ATP binding site [chemical binding]; other site 1198676004749 Q-loop/lid; other site 1198676004750 ABC transporter signature motif; other site 1198676004751 Walker B; other site 1198676004752 D-loop; other site 1198676004753 H-loop/switch region; other site 1198676004754 TOBE domain; Region: TOBE_2; pfam08402 1198676004755 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 1198676004756 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 1198676004757 hinge; other site 1198676004758 active site 1198676004759 S-adenosylmethionine synthetase; Validated; Region: PRK05250 1198676004760 S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438 1198676004761 S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772 1198676004762 S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773 1198676004763 hypothetical protein; Provisional; Region: PRK09040 1198676004764 Biotin operon repressor [Transcription]; Region: BirA; COG1654 1198676004765 bifunctional biotin--[acetyl-CoA-carboxylase] synthetase/biotin operon repressor; Provisional; Region: PRK11886 1198676004766 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; pfam03099 1198676004767 Biotin protein ligase C terminal domain; Region: BPL_C; pfam02237 1198676004768 Protein of unknown function (DUF3272); Region: DUF3272; pfam11676 1198676004769 DNA polymerase III subunits gamma and tau; Validated; Region: PRK05563 1198676004770 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1198676004771 Walker A motif; other site 1198676004772 ATP binding site [chemical binding]; other site 1198676004773 Walker B motif; other site 1198676004774 arginine finger; other site 1198676004775 DNA polymerase III subunits gamma and tau domain III; Region: DNA_pol3_gamma3; pfam12169 1198676004776 GAF domain-containing protein [Signal transduction mechanisms]; Region: COG1956 1198676004777 myosin-cross-reactive antigen; Provisional; Region: PRK13977 1198676004778 probable dihydroxyacetone kinase regulator; Region: DHAK_reg; TIGR02366 1198676004779 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1198676004780 threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK00413 1198676004781 TGS _ThrRS_N: ThrRS (threonyl-tRNA Synthetase) is a class II tRNA synthetase that couples threonine to its cognate tRNA. In addition to its catalytic and anticodon-binding domains, ThrRS has an N-terminal TGS domain, named after the ThrRS, GTPase, and...; Region: TGS_ThrRS_N; cd01667 1198676004782 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; pfam07973 1198676004783 Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771 1198676004784 active site 1198676004785 dimer interface [polypeptide binding]; other site 1198676004786 motif 1; other site 1198676004787 motif 2; other site 1198676004788 motif 3; other site 1198676004789 ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860 1198676004790 anticodon binding site; other site 1198676004791 AAA domain; Region: AAA_17; pfam13207 1198676004792 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1198676004793 This family is most closely related to the GT1 family of glycosyltransferases. UDP-glucose-diacylglycerol glucosyltransferase (UGDG; also known as 1,2-diacylglycerol 3-glucosyltransferase) catalyzes the transfer of glucose from UDP-glucose to 1; Region: GT1_UGDG_like; cd03817 1198676004794 putative ADP-binding pocket [chemical binding]; other site 1198676004795 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 1198676004796 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1198676004797 cytoplasmic alpha-amylase; Reviewed; Region: PRK09441 1198676004798 Alpha amylase catalytic domain found in bacterial and fungal Alpha amylases (also called 1,4-alpha-D-glucan-4-glucanohydrolase); Region: AmyAc_bac_fung_AmyA; cd11318 1198676004799 active site 1198676004800 Na/Ca binding site [ion binding]; other site 1198676004801 catalytic site [active] 1198676004802 Domain of unknown function (DUF1939); Region: DUF1939; pfam09154 1198676004803 catabolite control protein A; Region: ccpA; TIGR01481 1198676004804 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1198676004805 DNA binding site [nucleotide binding] 1198676004806 domain linker motif; other site 1198676004807 Ligand-binding domain of the catabolite control protein A (CcpA), which functions as the major transcriptional regulator of carbon catabolite repression/regulation; Region: PBP1_CcpA_like; cd06298 1198676004808 dimerization interface [polypeptide binding]; other site 1198676004809 effector binding site; other site 1198676004810 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 1198676004811 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 1198676004812 Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092 1198676004813 active site 1198676004814 CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575 1198676004815 Putative integral membrane protein DUF46; Region: DUF46; cl17511 1198676004816 Carbonic anhydrase alpha, prokaryotic-like subfamily. Carbonic anhydrases (CAs) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism: a nucleophilic attack of a zinc-bound hydroxide ion on carbon...; Region: alpha_CA_prokaryotic_like; cd03124 1198676004817 cellobiose phosphotransferase system IIC component; Reviewed; Region: celD; PRK09592 1198676004818 Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455 1198676004819 PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_lac; cd00215 1198676004820 methionine cluster; other site 1198676004821 active site 1198676004822 phosphorylation site [posttranslational modification] 1198676004823 metal binding site [ion binding]; metal-binding site 1198676004824 Transcriptional antiterminator [Transcription]; Region: BglG; COG3711 1198676004825 HTH domain; Region: HTH_11; pfam08279 1198676004826 Mga helix-turn-helix domain; Region: Mga; pfam05043 1198676004827 PRD domain; Region: PRD; pfam00874 1198676004828 PRD domain; Region: PRD; pfam00874 1198676004829 PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568 1198676004830 active site 1198676004831 P-loop; other site 1198676004832 phosphorylation site [posttranslational modification] 1198676004833 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cl00163 1198676004834 active site 1198676004835 phosphorylation site [posttranslational modification] 1198676004836 cellobiose phosphotransferase system IIB component; Reviewed; Region: celB; PRK09590 1198676004837 active site 1198676004838 P-loop; other site 1198676004839 phosphorylation site [posttranslational modification] 1198676004840 6-phospho-beta-glucosidase; Reviewed; Region: celA; PRK09589 1198676004841 beta-galactosidase; Region: BGL; TIGR03356 1198676004842 NAD(P)H:FMN oxidoreductase family. This domain catalyzes the reduction of flavin, nitrocompound, quinones and azo compounds using NADH or NADPH as an electron donor. The enzyme is a homodimer, and each monomer binds a FMN as co-factor. This family...; Region: NfsB_like_nitroreductase; cd02149 1198676004843 dimer interface [polypeptide binding]; other site 1198676004844 FMN binding site [chemical binding]; other site 1198676004845 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1198676004846 Glyoxalase I catalyzes the isomerization of the hemithioacetal, formed by a 2-oxoaldehyde and glutathione, to S-D-lactoylglutathione; Region: Glyoxalase_I; cd07233 1198676004847 dimer interface [polypeptide binding]; other site 1198676004848 active site 1198676004849 metal binding site [ion binding]; metal-binding site 1198676004850 glutathione binding site [chemical binding]; other site 1198676004851 Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294 1198676004852 SmpB-tmRNA interface; other site 1198676004853 ribonuclease R; Region: RNase_R; TIGR02063 1198676004854 Ribonuclease B OB domain; Region: OB_RNB; pfam08206 1198676004855 RNB domain; Region: RNB; pfam00773 1198676004856 S1_RNase_R: RNase R C-terminal S1 domain. RNase R is a processive 3' to 5' exoribonuclease, which is a homolog of RNase II. RNase R degrades RNA with secondary structure having a 3' overhang of at least 7 nucleotides. RNase R and PNPase...; Region: S1_RNase_R; cd04471 1198676004857 RNA binding site [nucleotide binding]; other site 1198676004858 preprotein translocase subunit SecG; Reviewed; Region: secG; PRK06870 1198676004859 50S ribosomal protein L33; Validated; Region: rpmG; PRK00595 1198676004860 drug efflux system protein MdtG; Provisional; Region: PRK09874 1198676004861 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1198676004862 putative substrate translocation pore; other site 1198676004863 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1198676004864 S-adenosylmethionine binding site [chemical binding]; other site 1198676004865 Dephospho-CoA kinase [Coenzyme metabolism]; Region: CoaE; COG0237 1198676004866 Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022 1198676004867 CoA-binding site [chemical binding]; other site 1198676004868 ATP-binding [chemical binding]; other site 1198676004869 formamidopyrimidine/5-formyluracil/ 5-hydroxymethyluracil DNA glycosylase; Validated; Region: PRK01103 1198676004870 N-terminal domain of Escherichia coli Fpg1/MutM and related bacterial DNA glycosylases; Region: EcFpg-like_N; cd08966 1198676004871 DNA binding site [nucleotide binding] 1198676004872 catalytic residue [active] 1198676004873 H2TH interface [polypeptide binding]; other site 1198676004874 putative catalytic residues [active] 1198676004875 turnover-facilitating residue; other site 1198676004876 intercalation triad [nucleotide binding]; other site 1198676004877 8OG recognition residue [nucleotide binding]; other site 1198676004878 putative reading head residues; other site 1198676004879 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 1198676004880 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 1198676004881 DinB superfamily; Region: DinB_2; pfam12867 1198676004882 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_18; cd04677 1198676004883 nudix motif; other site 1198676004884 GTPase Era; Reviewed; Region: era; PRK00089 1198676004885 E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163 1198676004886 G1 box; other site 1198676004887 GTP/Mg2+ binding site [chemical binding]; other site 1198676004888 Switch I region; other site 1198676004889 G2 box; other site 1198676004890 Switch II region; other site 1198676004891 G3 box; other site 1198676004892 G4 box; other site 1198676004893 G5 box; other site 1198676004894 KH domain; Region: KH_2; pfam07650 1198676004895 Diacylglycerol kinase [Cell envelope biogenesis, outer membrane]; Region: DgkA; COG0818 1198676004896 metal-binding heat shock protein; Provisional; Region: PRK00016 1198676004897 Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702 1198676004898 PhoH-like protein; Region: PhoH; pfam02562 1198676004899 hypothetical protein; Provisional; Region: PRK13672 1198676004900 methionine sulfoxide reductase A; Provisional; Region: PRK14054 1198676004901 Predicted RNA-bindining protein (contains S1 and HTH domains) [General function prediction only]; Region: COG2996 1198676004902 S1 domain; Region: S1_2; pfam13509 1198676004903 Ribosomal protein S1-like RNA-binding domain; Region: S1; smart00316 1198676004904 ribosome recycling factor; Reviewed; Region: frr; PRK00083 1198676004905 Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation. Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520 1198676004906 hinge region; other site 1198676004907 UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254 1198676004908 putative nucleotide binding site [chemical binding]; other site 1198676004909 uridine monophosphate binding site [chemical binding]; other site 1198676004910 homohexameric interface [polypeptide binding]; other site 1198676004911 Ribosomal protein L1. The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA. In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403 1198676004912 mRNA/rRNA interface [nucleotide binding]; other site 1198676004913 50S ribosomal protein L11; Validated; Region: rplK; PRK00140 1198676004914 Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349 1198676004915 23S rRNA interface [nucleotide binding]; other site 1198676004916 L7/L12 interface [polypeptide binding]; other site 1198676004917 putative thiostrepton binding site; other site 1198676004918 L25 interface [polypeptide binding]; other site 1198676004919 Protein of unknown function (DUF3397); Region: DUF3397; pfam11877 1198676004920 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 1198676004921 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 1198676004922 This domain directs oriented DNA translocation and forms a winged helix structure; Region: Ftsk_gamma; smart00843 1198676004923 Peptidyl-prolyl cis-trans isomerase (rotamase) - cyclophilin family [Posttranslational modification, protein turnover, chaperones]; Region: PpiB; COG0652 1198676004924 active site 1198676004925 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Validated; Region: PRK05584 1198676004926 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 1198676004927 dimer interface [polypeptide binding]; other site 1198676004928 ADP-ribose binding site [chemical binding]; other site 1198676004929 active site 1198676004930 nudix motif; other site 1198676004931 metal binding site [ion binding]; metal-binding site 1198676004932 bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase; Provisional; Region: glmU; PRK14354 1198676004933 N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540 1198676004934 Substrate binding site; other site 1198676004935 Mg++ binding site; other site 1198676004936 N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353 1198676004937 active site 1198676004938 substrate binding site [chemical binding]; other site 1198676004939 CoA binding site [chemical binding]; other site 1198676004940 ASC-1 homology domain, subfamily similar to Enterococcus faecalis Ef3133. The ASCH domain, a small beta-barrel domain found in all three kingdoms of life, resembles the RNA-binding PUA domain and may also interact with RNA. ASCH has been proposed to...; Region: ASCH_Ef3133_like; cd06553 1198676004941 methionyl-tRNA synthetase; Reviewed; Region: PRK12267 1198676004942 catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814 1198676004943 active site 1198676004944 HIGH motif; other site 1198676004945 KMSKS motif; other site 1198676004946 Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957 1198676004947 tRNA binding surface [nucleotide binding]; other site 1198676004948 anticodon binding site; other site 1198676004949 tRNA-binding-domain-containing Escherichia coli methionyl-tRNA synthetase (EcMetRS)-like proteins. This family includes EcMetRS and Aquifex aeolicus Trbp111 (AaTrbp111). This domain has general tRNA binding properties. MetRS aminoacylates methionine...; Region: tRNA_bind_EcMetRS_like; cd02800 1198676004950 dimer interface [polypeptide binding]; other site 1198676004951 putative tRNA-binding site [nucleotide binding]; other site 1198676004952 Predicted membrane protein [Function unknown]; Region: COG2323 1198676004953 Protein of unknown function (DUF3290); Region: DUF3290; pfam11694 1198676004954 tellurite resistance protein TehB; Provisional; Region: PRK12335 1198676004955 Domain of unknown function (DUF1971); Region: DUF1971; pfam09313 1198676004956 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1198676004957 S-adenosylmethionine binding site [chemical binding]; other site 1198676004958 Protein of unknown function (DUF1648); Region: DUF1648; pfam07853 1198676004959 SdpI/YhfL protein family; Region: SdpI; pfam13630 1198676004960 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1198676004961 dimerization interface [polypeptide binding]; other site 1198676004962 putative DNA binding site [nucleotide binding]; other site 1198676004963 putative Zn2+ binding site [ion binding]; other site 1198676004964 Human Ape1-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: Ape1-like_AP-endo; cd09087 1198676004965 active site 1198676004966 putative catalytic site [active] 1198676004967 DNA binding site [nucleotide binding] 1198676004968 putative phosphate binding site [ion binding]; other site 1198676004969 metal binding site A [ion binding]; metal-binding site 1198676004970 AP binding site [nucleotide binding]; other site 1198676004971 metal binding site B [ion binding]; metal-binding site 1198676004972 Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177 1198676004973 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 1198676004974 minor groove reading motif; other site 1198676004975 helix-hairpin-helix signature motif; other site 1198676004976 substrate binding pocket [chemical binding]; other site 1198676004977 active site 1198676004978 Arsenate Reductase (ArsC) family, unknown subfamily; uncharacterized proteins containing a CXXC motif with similarity to thioredoxin (TRX)-fold arsenic reductases, ArsC. Proteins containing a redox active CXXC motif like TRX and glutaredoxin (GRX)...; Region: ArsC_like; cd03036 1198676004979 ArsC family; Region: ArsC; pfam03960 1198676004980 putative ArsC-like catalytic residues; other site 1198676004981 putative TRX-like catalytic residues [active] 1198676004982 Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350 1198676004983 6-O-methylguanine DNA methyltransferase, ribonuclease-like domain; Region: Methyltransf_1N; pfam02870 1198676004984 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 1198676004985 DNA binding site [nucleotide binding] 1198676004986 active site 1198676004987 Putative D-3-Phosphoglycerate Dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_like_3; cd12174 1198676004988 D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain; Region: 2-Hacid_dh; pfam00389 1198676004989 putative ligand binding site [chemical binding]; other site 1198676004990 putative NAD binding site [chemical binding]; other site 1198676004991 putative catalytic site [active] 1198676004992 C-terminal ACT (regulatory) domain of D-3-Phosphoglycerate Dehydrogenase (3PGDH) found in fungi and bacteria; Region: ACT_3PGDH; cd04901 1198676004993 L-serine binding site [chemical binding]; other site 1198676004994 ACT domain interface; other site 1198676004995 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 1198676004996 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1198676004997 Coenzyme A binding pocket [chemical binding]; other site 1198676004998 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cl10015 1198676004999 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cl10015 1198676005000 3-phosphoserine/phosphohydroxythreonine aminotransferase; Provisional; Region: PRK05355 1198676005001 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1198676005002 catalytic residue [active] 1198676005003 Nitrogen regulatory protein PII [Amino acid transport and metabolism]; Region: GlnK; COG0347 1198676005004 Nitrogen regulatory protein P-II; Region: P-II; smart00938 1198676005005 Ammonia permease [Inorganic ion transport and metabolism]; Region: AmtB; COG0004 1198676005006 potential frameshift: common BLAST hit: gi|387785655|ref|YP_006250751.1| putative methylase 1198676005007 DNA replication intiation control protein YabA; Reviewed; Region: PRK13169 1198676005008 Uncharacterized homolog of PSP1 [Function unknown]; Region: COG1774 1198676005009 DNA polymerase III subunit delta'; Validated; Region: PRK07276 1198676005010 DNA polymerase III subunit delta'; Validated; Region: PRK08485 1198676005011 thymidylate kinase; Validated; Region: tmk; PRK00698 1198676005012 Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672 1198676005013 TMP-binding site; other site 1198676005014 ATP-binding site [chemical binding]; other site 1198676005015 FOG: CBS domain [General function prediction only]; Region: COG0517 1198676005016 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the acetoin utilization proteins in bacteria. Acetoin is a product of fermentative metabolism in many prokaryotic and eukaryotic microorganisms. They produce...; Region: CBS_pair_ACT_assoc2; cd04585 1198676005017 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 1198676005018 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 1198676005019 Walker A/P-loop; other site 1198676005020 ATP binding site [chemical binding]; other site 1198676005021 Q-loop/lid; other site 1198676005022 ABC transporter signature motif; other site 1198676005023 Walker B; other site 1198676005024 D-loop; other site 1198676005025 H-loop/switch region; other site 1198676005026 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 1198676005027 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 1198676005028 Walker A/P-loop; other site 1198676005029 ATP binding site [chemical binding]; other site 1198676005030 Q-loop/lid; other site 1198676005031 ABC transporter signature motif; other site 1198676005032 Walker B; other site 1198676005033 D-loop; other site 1198676005034 H-loop/switch region; other site 1198676005035 ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177 1198676005036 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 1198676005037 TM-ABC transporter signature motif; other site 1198676005038 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 1198676005039 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 1198676005040 TM-ABC transporter signature motif; other site 1198676005041 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 1198676005042 Type I periplasmic ligand-binding domain of uncharacterized ABC (Atpase Binding Cassette)-type active transport systems that are predicted to be involved in uptake of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_ligand_binding_like_12; cd06347 1198676005043 putative ligand binding site [chemical binding]; other site 1198676005044 hypothetical protein; Provisional; Region: PRK02302 1198676005045 Protein of unknown function (DUF964); Region: DUF964; pfam06133 1198676005046 Protease subunit of ATP-dependent Clp proteases [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: ClpP; COG0740 1198676005047 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 1198676005048 oligomer interface [polypeptide binding]; other site 1198676005049 active site residues [active] 1198676005050 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1198676005051 active site 1198676005052 Bifunctional PLP-dependent enzyme with beta-cystathionase and maltose regulon repressor activities [Amino acid transport and metabolism]; Region: MalY; COG1168 1198676005053 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1198676005054 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1198676005055 homodimer interface [polypeptide binding]; other site 1198676005056 catalytic residue [active] 1198676005057 potential frameshift: common BLAST hit: gi|387785639|ref|YP_006250735.1| cystathionine gamma-synthase 1198676005058 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 1198676005059 Stage V sporulation protein B, also known as Stage III sporulation protein F, and related proteins; Region: MATE_SpoVB_like; cd13124 1198676005060 UDP-N-acetylmuramoylalanyl-D-glutamate--L-lysine ligase; Provisional; Region: PRK14022 1198676005061 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 1198676005062 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 1198676005063 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 1198676005064 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1198676005065 BAAT / Acyl-CoA thioester hydrolase C terminal; Region: BAAT_C; pfam08840 1198676005066 PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in bacteria and archaea; Region: PEBP_bact_arch; cd00865 1198676005067 substrate binding site [chemical binding]; other site 1198676005068 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_19; cd07262 1198676005069 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1198676005070 Putative intracellular protease/amidase [General function prediction only]; Region: ThiJ; COG0693 1198676005071 Type 1 glutamine amidotransferase (GATase1)-like domain found in a subgroup of proteins similar to PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_3; cd03140 1198676005072 conserved cys residue [active] 1198676005073 Predicted transcriptional regulator [Transcription]; Region: COG2378 1198676005074 HTH domain; Region: HTH_11; pfam08279 1198676005075 WYL domain; Region: WYL; pfam13280 1198676005076 Domain of unknown function (DUF1803); Region: DUF1803; pfam08820 1198676005077 Domain of unknown function (DUF1803); Region: DUF1803; pfam08820 1198676005078 putative manganese-dependent inorganic pyrophosphatase; Provisional; Region: PRK05427 1198676005079 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 1198676005080 DHHA2 domain; Region: DHHA2; pfam02833 1198676005081 D-alanyl-lipoteichoic acid biosynthesis protein DltD; Region: LTA_DltD; TIGR04092 1198676005082 DltD N-terminal region; Region: DltD_N; pfam04915 1198676005083 DltD central region; Region: DltD_M; pfam04918 1198676005084 DltD C-terminal region; Region: DltD_C; pfam04914 1198676005085 D-alanine--poly(phosphoribitol) ligase subunit 2; Validated; Region: PRK05087 1198676005086 D-alanyl-lipoteichoic acid biosynthesis protein DltB; Region: LTA_dltB; TIGR04091 1198676005087 D-alanine--poly(phosphoribitol) ligase subunit 1; Provisional; Region: PRK04813 1198676005088 D-alanine:D-alanyl carrier protein ligase (DltA); Region: DltA; cd05945 1198676005089 acyl-activating enzyme (AAE) consensus motif; other site 1198676005090 AMP binding site [chemical binding]; other site 1198676005091 pyruvate formate-lyase 1-activating enzyme; Region: PFLA; TIGR02493 1198676005092 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1198676005093 FeS/SAM binding site; other site 1198676005094 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 1198676005095 Domain of unknown function DUF21; Region: DUF21; pfam01595 1198676005096 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 1198676005097 Transporter associated domain; Region: CorC_HlyC; smart01091 1198676005098 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 1198676005099 Domain of unknown function DUF20; Region: UPF0118; pfam01594 1198676005100 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 1198676005101 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1198676005102 Walker A/P-loop; other site 1198676005103 ATP binding site [chemical binding]; other site 1198676005104 Q-loop/lid; other site 1198676005105 ABC transporter signature motif; other site 1198676005106 Walker B; other site 1198676005107 D-loop; other site 1198676005108 H-loop/switch region; other site 1198676005109 Putative rRNA methylase; Region: rRNA_methylase; pfam06962 1198676005110 Predicted Fe-S oxidoreductase [General function prediction only]; Region: COG1242 1198676005111 LrgB-like family; Region: LrgB; pfam04172 1198676005112 Putative effector of murein hydrolase LrgA [General function prediction only]; Region: COG1380 1198676005113 PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392 1198676005114 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 1198676005115 active site 1198676005116 Predicted membrane protein [Function unknown]; Region: COG3601 1198676005117 Protein of unknown function (DUF3816); Region: DUF3816; pfam12822 1198676005118 Predicted transcriptional regulators [Transcription]; Region: COG1695 1198676005119 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 1198676005120 Predicted membrane protein [Function unknown]; Region: COG4709 1198676005121 Domain of unknown function (DUF4097); Region: DUF4097; pfam13349 1198676005122 Domain of unknown function (DUF4098); Region: DUF4098; pfam13345 1198676005123 Predicted rRNA methylase (SpoU class) [Translation, ribosomal structure and biogenesis]; Region: CspR; COG0219 1198676005124 TrkA-N domain; Region: TrkA_N; pfam02254 1198676005125 potassium transporter peripheral membrane component; Reviewed; Region: trkA; PRK09496 1198676005126 TrkA-C domain; Region: TrkA_C; pfam02080 1198676005127 TrkA-N domain; Region: TrkA_N; pfam02254 1198676005128 TrkA-C domain; Region: TrkA_C; pfam02080 1198676005129 Trk-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: TrkG; COG0168 1198676005130 potassium uptake protein, TrkH family; Region: 2a38; TIGR00933 1198676005131 hypothetical protein; Validated; Region: PRK00041 1198676005132 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 1198676005133 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1198676005134 RNA binding surface [nucleotide binding]; other site 1198676005135 Pseudouridine synthases, RsuA subfamily; Region: PseudoU_synth_RsuA_like; cd02870 1198676005136 active site 1198676005137 segregation and condensation protein B; Reviewed; Region: scpB; PRK00135 1198676005138 segregation and condensation protein A; Reviewed; Region: scpA; PRK00104 1198676005139 site-specific tyrosine recombinase XerD-like protein; Reviewed; Region: xerD; PRK02436 1198676005140 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 1198676005141 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 1198676005142 DNA binding site [nucleotide binding] 1198676005143 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_30; cd04643 1198676005144 FOG: CBS domain [General function prediction only]; Region: COG0517 1198676005145 Escherichia coli YfcE and related proteins, metallophosphatase domain; Region: MPP_YfcE; cd00841 1198676005146 active site 1198676005147 metal binding site [ion binding]; metal-binding site 1198676005148 homotetramer interface [polypeptide binding]; other site 1198676005149 potential frameshift: common BLAST hit: gi|387785600|ref|YP_006250696.1| putative deoxyribonucleotide triphosphate pyrophosphatase 1198676005150 glutamate racemase; Provisional; Region: PRK00865 1198676005151 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3763 1198676005152 Diaminopimelate decarboxylase [Amino acid transport and metabolism]; Region: LysA; COG0019 1198676005153 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828 1198676005154 active site 1198676005155 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 1198676005156 substrate binding site [chemical binding]; other site 1198676005157 catalytic residues [active] 1198676005158 dimer interface [polypeptide binding]; other site 1198676005159 Integral membrane protein, interacts with FtsH [General function prediction only]; Region: COG0670 1198676005160 Bacterial BAX inhibitor (BI)-1/YccA-like proteins; Region: BI-1-like_bacterial; cd10432 1198676005161 Predicted HD superfamily hydrolase [General function prediction only]; Region: COG1418 1198676005162 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1198676005163 Zn2+ binding site [ion binding]; other site 1198676005164 Mg2+ binding site [ion binding]; other site 1198676005165 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 1198676005166 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032 1198676005167 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 1198676005168 acylphosphatase; Provisional; Region: PRK14434 1198676005169 OxaA-like protein precursor; Provisional; Region: PRK02463 1198676005170 60Kd inner membrane protein; Region: 60KD_IMP; cl00489 1198676005171 transcription elongation factor GreA; Reviewed; Region: greA; PRK00226 1198676005172 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 1198676005173 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 1198676005174 potential frameshift: common BLAST hit: gi|387785590|ref|YP_006250686.1| putative aminodeoxychorismate lyase 1198676005175 Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247 1198676005176 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1198676005177 Coenzyme A binding pocket [chemical binding]; other site 1198676005178 UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421 1198676005179 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 1198676005180 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 1198676005181 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 1198676005182 SWIM zinc finger; Region: SWIM; pfam04434 1198676005183 Bacterial SNF2 helicase associated; Region: SNF2_assoc; pfam08455 1198676005184 SNF2 family N-terminal domain; Region: SNF2_N; pfam00176 1198676005185 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1198676005186 ATP binding site [chemical binding]; other site 1198676005187 putative Mg++ binding site [ion binding]; other site 1198676005188 Superfamily II DNA and RNA helicases [DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis]; Region: SrmB; COG0513 1198676005189 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1198676005190 nucleotide binding region [chemical binding]; other site 1198676005191 ATP-binding site [chemical binding]; other site 1198676005192 acetyl-CoA carboxylase subunit alpha; Provisional; Region: PRK12319 1198676005193 acetyl-CoA carboxylase subunit beta; Validated; Region: PRK05654 1198676005194 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 1198676005195 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591 1198676005196 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 1198676005197 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 1198676005198 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 1198676005199 FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288 1198676005200 acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated; Region: PRK06302 1198676005201 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 1198676005202 carboxyltransferase (CT) interaction site; other site 1198676005203 biotinylation site [posttranslational modification]; other site 1198676005204 3-oxoacyl-(acyl carrier protein) synthase II; Reviewed; Region: PRK07314 1198676005205 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 1198676005206 dimer interface [polypeptide binding]; other site 1198676005207 active site 1198676005208 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 1198676005209 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1198676005210 NAD(P) binding site [chemical binding]; other site 1198676005211 active site 1198676005212 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 1198676005213 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 1198676005214 putative enoyl-[acyl-carrier-protein] reductase II; Region: enACPred_II; TIGR03151 1198676005215 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 1198676005216 FMN binding site [chemical binding]; other site 1198676005217 substrate binding site [chemical binding]; other site 1198676005218 putative catalytic residue [active] 1198676005219 acyl carrier protein; Provisional; Region: acpP; PRK00982 1198676005220 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352 1198676005221 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 1198676005222 dimer interface [polypeptide binding]; other site 1198676005223 active site 1198676005224 CoA binding pocket [chemical binding]; other site 1198676005225 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1198676005226 MarR family; Region: MarR_2; pfam12802 1198676005227 enoyl-CoA hydratase; Provisional; Region: PRK07260 1198676005228 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1198676005229 substrate binding site [chemical binding]; other site 1198676005230 oxyanion hole (OAH) forming residues; other site 1198676005231 trimer interface [polypeptide binding]; other site 1198676005232 Predicted phosphatase/phosphohexomutase [General function prediction only]; Region: COG0637 1198676005233 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1198676005234 motif II; other site 1198676005235 aspartate kinase; Reviewed; Region: PRK09034 1198676005236 AAK_AKiii-YclM-BS: Amino Acid Kinase Superfamily (AAK), AKiii-YclM-BS; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the lysine plus threonine-sensitive aspartokinase isoenzyme AKIII, a monofunctional class enzyme found in...; Region: AAK_AKiii-YclM-BS; cd04245 1198676005237 putative catalytic residues [active] 1198676005238 putative nucleotide binding site [chemical binding]; other site 1198676005239 putative aspartate binding site [chemical binding]; other site 1198676005240 ACT domains located C-terminal to the catalytic domain of the lysine plus threonine-sensitive aspartokinase isoenzyme AKIII; Region: ACT_AKiii-YclM-BS_1; cd04911 1198676005241 allosteric regulatory residue; other site 1198676005242 ACT domains located C-terminal to the catalytic domain of the lysine plus threonine-sensitive aspartokinase isoenzyme AKIII; Region: ACT_AKiii-YclM-BS_2; cd04916 1198676005243 CRISPR/Cas system-associated protein Cas2; Region: Cas2_I_II_III; cd09725 1198676005244 potential frameshift: common BLAST hit: gi|387785565|ref|YP_006250661.1| CRISPR-associated protein cas1 1198676005245 CRISPR-associated protein Cas4 (RecB family exonuclease) [Defense mechanisms]; Region: COG1468 1198676005246 CRISPR/Cas system-associated RAMP superfamily protein Cas7; Region: Cas7_I-C; cd09689 1198676005247 potential frameshift: common BLAST hit: gi|387785562|ref|YP_006250658.1| CRISPR-associated protein csd1 1198676005248 CRISPR/Cas system-associated RAMP superfamily protein Cas5; Region: Cas5_I-C; cd09651 1198676005249 CRISPR-associated protein (Cas_Cas5); Region: Cas_Cas5d; pfam09704 1198676005250 CRISPR/Cas system-associated protein Cas3'' Region: Cas3''_I; cd09641 1198676005251 CRISPR-associated helicase Cas3 [Defense mechanisms]; Region: COG1203 1198676005252 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 1198676005253 PIN (PilT N terminus) domain: Superfamily; Region: PIN_SF; cl14812 1198676005254 putative active site [active] 1198676005255 PIN domain; Region: PIN_3; pfam13470 1198676005256 Antidote-toxin recognition MazE; Region: Antitoxin-MazE; cl00877 1198676005257 valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729 1198676005258 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 1198676005259 active site 1198676005260 HIGH motif; other site 1198676005261 nucleotide binding site [chemical binding]; other site 1198676005262 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 1198676005263 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 1198676005264 active site 1198676005265 KMSKS motif; other site 1198676005266 Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962 1198676005267 tRNA binding surface [nucleotide binding]; other site 1198676005268 anticodon binding site; other site 1198676005269 Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458 1198676005270 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 1198676005271 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 1198676005272 Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family [General function prediction only]; Region: COG1853 1198676005273 Domain of unknown function (DUF1912); Region: DUF1912; pfam08930 1198676005274 NrdI Flavodoxin like; Region: Flavodoxin_NdrI; cl17293 1198676005275 SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase [Translation, ribosomal structure and biogenesis]; Region: TrmA; COG2265 1198676005276 TRAM domain; Region: TRAM; cl01282 1198676005277 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 1198676005278 recombination regulator RecX; Provisional; Region: recX; PRK14135 1198676005279 hypothetical protein; Provisional; Region: PRK13662 1198676005280 Staphylococcal protein of unknown function (DUF960); Region: DUF960; pfam06124 1198676005281 prolyl-tRNA synthetase; Provisional; Region: PRK09194 1198676005282 Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_prok; cd00779 1198676005283 dimer interface [polypeptide binding]; other site 1198676005284 motif 1; other site 1198676005285 active site 1198676005286 motif 2; other site 1198676005287 INS is an amino acid-editing domain inserted (INS) into the bacterial class II prolyl-tRNA synthetase (ProRS) however, this CD is not exclusively bacterial. It is also found at the N-terminus of the eukaryotic/archaea-like ProRS's of yeasts and...; Region: ProRS-INS; cd04334 1198676005288 putative deacylase active site [active] 1198676005289 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 1198676005290 active site 1198676005291 motif 3; other site 1198676005292 ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding; Region: ProRS_anticodon_short; cd00861 1198676005293 anticodon binding site; other site 1198676005294 RIP metalloprotease RseP; Region: TIGR00054 1198676005295 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 1198676005296 active site 1198676005297 Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020 1198676005298 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 1198676005299 protein binding site [polypeptide binding]; other site 1198676005300 Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020 1198676005301 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 1198676005302 putative substrate binding region [chemical binding]; other site 1198676005303 CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575 1198676005304 Cytidylyltransferase family; Region: CTP_transf_1; pfam01148 1198676005305 Undecaprenyl pyrophosphate synthase [Lipid metabolism]; Region: UppS; COG0020 1198676005306 Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cd00475 1198676005307 catalytic residue [active] 1198676005308 putative FPP diphosphate binding site; other site 1198676005309 putative FPP binding hydrophobic cleft; other site 1198676005310 dimer interface [polypeptide binding]; other site 1198676005311 putative IPP diphosphate binding site; other site 1198676005312 preprotein translocase subunit YajC; Validated; Region: yajC; PRK06531 1198676005313 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 1198676005314 catalytic residues [active] 1198676005315 hypothetical protein; Provisional; Region: PRK12378 1198676005316 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 1198676005317 Helix-Turn-Helix DNA binding domain of the transcription regulators TipAL, Mta, and SkgA; Region: HTH_TipAL-Mta; cd01106 1198676005318 DNA binding residues [nucleotide binding] 1198676005319 dimer interface [polypeptide binding]; other site 1198676005320 TipAS antibiotic-recognition domain; Region: TipAS; pfam07739 1198676005321 hypothetical protein; Provisional; Region: PRK13670 1198676005322 HIGH Nucleotidyl Transferase; Region: HIGH_NTase1; cl17673 1198676005323 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1198676005324 S-adenosylmethionine binding site [chemical binding]; other site 1198676005325 Uncharacterized homolog of plant Iojap protein [Function unknown]; Region: COG0799 1198676005326 Predicted HD superfamily hydrolase involved in NAD metabolism [Coenzyme metabolism]; Region: COG1713 1198676005327 Zn2+ binding site [ion binding]; other site 1198676005328 Mg2+ binding site [ion binding]; other site 1198676005329 nicotinic acid mononucleotide adenylyltransferase; Provisional; Region: nadD; PRK00071 1198676005330 Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165 1198676005331 active site 1198676005332 (T/H)XGH motif; other site 1198676005333 Predicted RNA-binding protein containing KH domain, possibly ribosomal protein [Translation, ribosomal structure and biogenesis]; Region: COG1534 1198676005334 GTPase YqeH; Provisional; Region: PRK13796 1198676005335 Circularly permuted YqeH GTPase; Region: YqeH; cd01855 1198676005336 GTP/Mg2+ binding site [chemical binding]; other site 1198676005337 G4 box; other site 1198676005338 G5 box; other site 1198676005339 G1 box; other site 1198676005340 Switch I region; other site 1198676005341 G2 box; other site 1198676005342 G3 box; other site 1198676005343 Switch II region; other site 1198676005344 Predicted hydrolase of the HAD superfamily [General function prediction only]; Region: COG2179 1198676005345 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1198676005346 active site 1198676005347 motif I; other site 1198676005348 motif II; other site 1198676005349 Protein of unknown function (DUF4230); Region: DUF4230; pfam14014 1198676005350 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1198676005351 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1198676005352 This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784 1198676005353 glycosyltransferase, MGT family; Region: MGT; TIGR01426 1198676005354 active site 1198676005355 TDP-binding site; other site 1198676005356 acceptor substrate-binding pocket; other site 1198676005357 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 1198676005358 EamA-like transporter family; Region: EamA; pfam00892 1198676005359 aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477 1198676005360 GatB/GatE catalytic domain; Region: GatB_N; pfam02934 1198676005361 GatB domain; Region: GatB_Yqey; pfam02637 1198676005362 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 1198676005363 aspartyl/glutamyl-tRNA amidotransferase subunit A; Reviewed; Region: gatA; PRK00012 1198676005364 aspartyl/glutamyl-tRNA amidotransferase subunit C; Reviewed; Region: gatC; PRK00034 1198676005365 aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476 1198676005366 EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317 1198676005367 dimer interface [polypeptide binding]; other site 1198676005368 anticodon binding site; other site 1198676005369 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777 1198676005370 homodimer interface [polypeptide binding]; other site 1198676005371 motif 1; other site 1198676005372 active site 1198676005373 motif 2; other site 1198676005374 GAD domain; Region: GAD; pfam02938 1198676005375 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 1198676005376 active site 1198676005377 motif 3; other site 1198676005378 Isochorismatase family; Region: Isochorismatase; pfam00857 1198676005379 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 1198676005380 catalytic triad [active] 1198676005381 conserved cis-peptide bond; other site 1198676005382 transcriptional repressor CodY; Validated; Region: PRK04158 1198676005383 CodY GAF-like domain; Region: CodY; pfam06018 1198676005384 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1198676005385 dimerization interface [polypeptide binding]; other site 1198676005386 putative Zn2+ binding site [ion binding]; other site 1198676005387 putative DNA binding site [nucleotide binding]; other site 1198676005388 aminotransferase AlaT; Validated; Region: PRK09265 1198676005389 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1198676005390 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1198676005391 homodimer interface [polypeptide binding]; other site 1198676005392 catalytic residue [active] 1198676005393 BioY family; Region: BioY; pfam02632 1198676005394 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 1198676005395 Ligand Binding Site [chemical binding]; other site 1198676005396 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1198676005397 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 1198676005398 active site 1198676005399 motif I; other site 1198676005400 motif II; other site 1198676005401 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1198676005402 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4696 1198676005403 metal binding site [ion binding]; metal-binding site 1198676005404 Type II (periplasmic) bacterial L-asparaginase; Region: L-asparaginase_II; cd08964 1198676005405 active site 1198676005406 homotetramer interface [polypeptide binding]; other site 1198676005407 homodimer interface [polypeptide binding]; other site 1198676005408 ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917 1198676005409 RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488 1198676005410 generic binding surface II; other site 1198676005411 ssDNA binding site; other site 1198676005412 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1198676005413 ATP binding site [chemical binding]; other site 1198676005414 putative Mg++ binding site [ion binding]; other site 1198676005415 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1198676005416 nucleotide binding region [chemical binding]; other site 1198676005417 ATP-binding site [chemical binding]; other site 1198676005418 alanine racemase; Reviewed; Region: alr; PRK00053 1198676005419 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430 1198676005420 active site 1198676005421 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 1198676005422 dimer interface [polypeptide binding]; other site 1198676005423 substrate binding site [chemical binding]; other site 1198676005424 catalytic residues [active] 1198676005425 4'-phosphopantetheinyl transferase; Provisional; Region: acpS; PRK00070 1198676005426 phospho-2-dehydro-3-deoxyheptonate aldolase; Provisional; Region: PRK12755 1198676005427 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 1198676005428 3-deoxy-D-arabino-heptulosonate 7-phosphate (DAHP) synthase [Amino acid transport and metabolism]; Region: AroG; cl17260 1198676005429 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 1198676005430 preprotein translocase subunit SecA; Reviewed; Region: PRK12904 1198676005431 SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958 1198676005432 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1198676005433 nucleotide binding region [chemical binding]; other site 1198676005434 ATP-binding site [chemical binding]; other site 1198676005435 SEC-C motif; Region: SEC-C; pfam02810 1198676005436 Phosphomannose isomerase [Carbohydrate transport and metabolism]; Region: ManA; COG1482 1198676005437 mannose-6-phosphate isomerase, class I; Region: manA; TIGR00218 1198676005438 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 1198676005439 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 1198676005440 nucleotide binding site [chemical binding]; other site 1198676005441 PTS system, sucrose-specific IIBC component; Region: PTS-II-BC-sucr; TIGR01996 1198676005442 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 1198676005443 active site turn [active] 1198676005444 phosphorylation site [posttranslational modification] 1198676005445 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 1198676005446 PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_glc; cd00210 1198676005447 HPr interaction site; other site 1198676005448 glycerol kinase (GK) interaction site [polypeptide binding]; other site 1198676005449 active site 1198676005450 phosphorylation site [posttranslational modification] 1198676005451 potential frameshift: common BLAST hit: gi|290579821|ref|YP_003484213.1| sucrose-6-phosphate hydrolase 1198676005452 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1198676005453 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1198676005454 DNA binding site [nucleotide binding] 1198676005455 domain linker motif; other site 1198676005456 Ligand binding domain of the lacI-like transcription regulator from a novel metal-reducing bacterium Alkaliphilus Metalliredigens (strain Qymf) and its close homologs; Region: PBP1_Qymf_like; cd06291 1198676005457 dimerization interface [polypeptide binding]; other site 1198676005458 ligand binding site [chemical binding]; other site 1198676005459 sodium binding site [ion binding]; other site 1198676005460 transcription antitermination protein NusB; Reviewed; Region: nusB; PRK00202 1198676005461 putative RNA binding site [nucleotide binding]; other site 1198676005462 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1302 1198676005463 elongation factor P; Validated; Region: PRK00529 1198676005464 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 1198676005465 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 1198676005466 RNA binding site [nucleotide binding]; other site 1198676005467 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 1198676005468 RNA binding site [nucleotide binding]; other site 1198676005469 Ion transport protein; Region: Ion_trans; pfam00520 1198676005470 Ion channel; Region: Ion_trans_2; pfam07885 1198676005471 Deoxycytidylate deaminase domain. Deoxycytidylate deaminase catalyzes the deamination of dCMP to dUMP, providing the nucleotide substrate for thymidylate synthase. The enzyme binds Zn++, which is required for catalytic activity. The activity of the...; Region: deoxycytidylate_deaminase; cd01286 1198676005472 catalytic motif [active] 1198676005473 Zn binding site [ion binding]; other site 1198676005474 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 1198676005475 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 1198676005476 Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092 1198676005477 active site 1198676005478 potential frameshift: common BLAST hit: gi|24380212|ref|NP_722167.1| excinuclease ABC subunit A 1198676005479 cell division protein; Validated; Region: ftsH; CHL00176 1198676005480 Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598 1198676005481 uncharacterized bacterial subfamily of the Escherichia coli CorA-Salmonella typhimurium ZntB family; Region: EcCorA_ZntB-like_u2; cd12827 1198676005482 Cl binding site [ion binding]; other site 1198676005483 oligomer interface [polypeptide binding]; other site 1198676005484 Protein of unknown function (DUF1129); Region: DUF1129; pfam06570 1198676005485 LytTr DNA-binding domain; Region: LytTR; pfam04397 1198676005486 TraX protein; Region: TraX; cl05434 1198676005487 30S ribosomal protein S18; Reviewed; Region: rpsR; PRK00391 1198676005488 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 1198676005489 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 1198676005490 dimer interface [polypeptide binding]; other site 1198676005491 ssDNA binding site [nucleotide binding]; other site 1198676005492 tetramer (dimer of dimers) interface [polypeptide binding]; other site 1198676005493 30S ribosomal protein S6; Reviewed; Region: rpsF; PRK00453 1198676005494 A/G-specific DNA glycosylase [DNA replication, recombination, and repair]; Region: MutY; COG1194 1198676005495 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 1198676005496 minor groove reading motif; other site 1198676005497 helix-hairpin-helix signature motif; other site 1198676005498 substrate binding pocket [chemical binding]; other site 1198676005499 active site 1198676005500 DNA glycosylase (MutY in bacteria and hMYH in humans) is responsible for repairing misread A*oxoG residues to C*G by removing the inappropriately paired adenine base from the DNA backbone. It belongs to the Nudix hydrolase superfamily and is important...; Region: DNA_Glycosylase_C; cd03431 1198676005501 DNA binding and oxoG recognition site [nucleotide binding] 1198676005502 formaldehyde dehydrogenase (FDH)-like; Region: FDH_like_ADH3; cd08287 1198676005503 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 1198676005504 catalytic Zn binding site [ion binding]; other site 1198676005505 NAD(P) binding site [chemical binding]; other site 1198676005506 structural Zn binding site [ion binding]; other site 1198676005507 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 1198676005508 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 1198676005509 catalytic residues [active] 1198676005510 recombination and DNA strand exchange inhibitor protein; Reviewed; Region: PRK00409 1198676005511 MutS domain III; Region: MutS_III; pfam05192 1198676005512 ATP-binding cassette domain of MutS2; Region: ABC_MutS2; cd03280 1198676005513 Walker A/P-loop; other site 1198676005514 ATP binding site [chemical binding]; other site 1198676005515 Q-loop/lid; other site 1198676005516 ABC transporter signature motif; other site 1198676005517 Walker B; other site 1198676005518 D-loop; other site 1198676005519 H-loop/switch region; other site 1198676005520 Smr domain; Region: Smr; pfam01713 1198676005521 Uncharacterized membrane protein, required for colicin V production [General function prediction only]; Region: CvpA; COG1286 1198676005522 Colicin V production protein; Region: Colicin_V; pfam02674 1198676005523 ribonuclease HIII; Provisional; Region: PRK00996 1198676005524 Domain of unknown function (DUF3378); Region: DUF3378; pfam11858 1198676005525 bacterial Ribonuclease HIII-like; Region: RNase_HII_bacteria_HIII_like; cd06590 1198676005526 RNA/DNA hybrid binding site [nucleotide binding]; other site 1198676005527 active site 1198676005528 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 1198676005529 The S24, S26 LexA/signal peptidase superfamily contains LexA-related and type I signal peptidase families. The S24 LexA protein domains include: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC 3.4.21.88), the...; Region: Peptidase_S24_S26; cd06462 1198676005530 Catalytic site [active] 1198676005531 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 1198676005532 helicase, putative, RecD/TraA family; Region: recD_rel; TIGR01448 1198676005533 H3TH domains of structure-specific 5' nucleases (or flap endonuclease-1-like) involved in DNA replication, repair, and recombination; Region: H3TH_StructSpec-5'-nucleases; cl14815 1198676005534 DNA binding site [nucleotide binding] 1198676005535 AAA domain; Region: AAA_30; pfam13604 1198676005536 Family description; Region: UvrD_C_2; pfam13538 1198676005537 PTS system mannose-specific transporter subunits IIAB; Provisional; Region: PRK15088 1198676005538 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006 1198676005539 active pocket/dimerization site; other site 1198676005540 active site 1198676005541 phosphorylation site [posttranslational modification] 1198676005542 PTS_IIB, PTS system, Mannose/sorbose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_man; cd00001 1198676005543 active site 1198676005544 phosphorylation site [posttranslational modification] 1198676005545 PTS system mannose-specific transporter subunit IIC; Provisional; Region: PRK15065 1198676005546 Phosphotransferase system, mannose/fructose/N-acetylgalactosamine-specific component IID [Carbohydrate transport and metabolism]; Region: ManZ; COG3716 1198676005547 A sub-family of peptidase family C39. Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various...; Region: Peptidase_C39B; cd02418 1198676005548 ABC-type bacteriocin transporter; Region: bacteriocin_ABC; TIGR01193 1198676005549 putative active site [active] 1198676005550 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1198676005551 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1198676005552 Walker A/P-loop; other site 1198676005553 ATP binding site [chemical binding]; other site 1198676005554 Q-loop/lid; other site 1198676005555 ABC transporter signature motif; other site 1198676005556 Walker B; other site 1198676005557 D-loop; other site 1198676005558 H-loop/switch region; other site 1198676005559 Domain of unknown function (DUF956); Region: DUF956; pfam06115 1198676005560 Predicted O-acyltransferase [General function prediction only]; Region: COG3274 1198676005561 Acyltransferase family; Region: Acyl_transf_3; pfam01757 1198676005562 seryl-tRNA synthetase; Provisional; Region: PRK05431 1198676005563 Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403 1198676005564 Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770 1198676005565 dimer interface [polypeptide binding]; other site 1198676005566 active site 1198676005567 motif 1; other site 1198676005568 motif 2; other site 1198676005569 motif 3; other site 1198676005570 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 1198676005571 catalytic residues [active] 1198676005572 COMC family; Region: ComC; pfam03047 1198676005573 COMC family; Region: ComC; pfam03047 1198676005574 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 1198676005575 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 1198676005576 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1198676005577 active site 1198676005578 phosphorylation site [posttranslational modification] 1198676005579 intermolecular recognition site; other site 1198676005580 dimerization interface [polypeptide binding]; other site 1198676005581 LytTr DNA-binding domain; Region: LytTR; pfam04397 1198676005582 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 1198676005583 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 1198676005584 GTP-binding protein Der; Reviewed; Region: PRK00093 1198676005585 EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894 1198676005586 G1 box; other site 1198676005587 GTP/Mg2+ binding site [chemical binding]; other site 1198676005588 Switch I region; other site 1198676005589 G2 box; other site 1198676005590 Switch II region; other site 1198676005591 G3 box; other site 1198676005592 G4 box; other site 1198676005593 G5 box; other site 1198676005594 EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895 1198676005595 G1 box; other site 1198676005596 GTP/Mg2+ binding site [chemical binding]; other site 1198676005597 Switch I region; other site 1198676005598 G2 box; other site 1198676005599 G3 box; other site 1198676005600 Switch II region; other site 1198676005601 G4 box; other site 1198676005602 G5 box; other site 1198676005603 primosomal protein DnaI; Reviewed; Region: PRK08939 1198676005604 Primosomal protein DnaI N-terminus; Region: DnaI_N; pfam07319 1198676005605 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1198676005606 Walker A motif; other site 1198676005607 ATP binding site [chemical binding]; other site 1198676005608 Walker B motif; other site 1198676005609 potential frameshift: common BLAST hit: gi|387785435|ref|YP_006250531.1| putative chromosome replication protein 1198676005610 transcriptional regulator NrdR; Validated; Region: nrdR; PRK00464 1198676005611 ATP cone domain; Region: ATP-cone; pfam03477 1198676005612 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1198676005613 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1198676005614 active site 1198676005615 phosphorylation site [posttranslational modification] 1198676005616 intermolecular recognition site; other site 1198676005617 dimerization interface [polypeptide binding]; other site 1198676005618 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1198676005619 DNA binding site [nucleotide binding] 1198676005620 Predicted metal-binding, possibly nucleic acid-binding protein [General function prediction only]; Region: COG1399 1198676005621 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1198676005622 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1198676005623 Transcriptional regulator C-terminal region; Region: TetR_C_8; pfam14278 1198676005624 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 1198676005625 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 1198676005626 Walker A/P-loop; other site 1198676005627 ATP binding site [chemical binding]; other site 1198676005628 Q-loop/lid; other site 1198676005629 ABC transporter signature motif; other site 1198676005630 Walker B; other site 1198676005631 D-loop; other site 1198676005632 H-loop/switch region; other site 1198676005633 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 1198676005634 FtsX-like permease family; Region: FtsX; pfam02687 1198676005635 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 1198676005636 FtsX-like permease family; Region: FtsX; pfam02687 1198676005637 heat shock protein HtpX; Provisional; Region: PRK04897 1198676005638 Uncharacterized conserved protein [Function unknown]; Region: LemA; COG1704 1198676005639 Predicted S-adenosylmethionine-dependent methyltransferase involved in bacterial cell division [Cell envelope biogenesis, outer membrane]; Region: GidB; COG0357 1198676005640 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1198676005641 S-adenosylmethionine binding site [chemical binding]; other site 1198676005642 ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619 1198676005643 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 1198676005644 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 1198676005645 Walker A/P-loop; other site 1198676005646 ATP binding site [chemical binding]; other site 1198676005647 Q-loop/lid; other site 1198676005648 ABC transporter signature motif; other site 1198676005649 Walker B; other site 1198676005650 D-loop; other site 1198676005651 H-loop/switch region; other site 1198676005652 ATP-binding cassette cobalt transporter; Region: DUF3744; pfam12558 1198676005653 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 1198676005654 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 1198676005655 Walker A/P-loop; other site 1198676005656 ATP binding site [chemical binding]; other site 1198676005657 Q-loop/lid; other site 1198676005658 ABC transporter signature motif; other site 1198676005659 Walker B; other site 1198676005660 D-loop; other site 1198676005661 H-loop/switch region; other site 1198676005662 hypothetical protein; Provisional; Region: PRK13661 1198676005663 Uncharacterized conserved protein [Function unknown]; Region: COG1912 1198676005664 Predicted amidohydrolase [General function prediction only]; Region: COG0388 1198676005665 Uncharacterized subgroup of the nitrilase superfamily (putative class 13 nitrilases); Region: nitrilase_5; cd07583 1198676005666 putative active site [active] 1198676005667 catalytic triad [active] 1198676005668 putative dimer interface [polypeptide binding]; other site 1198676005669 ABC-type metal ion transport system, permease component [Inorganic ion transport and metabolism]; Region: AbcD; COG2011 1198676005670 dimer interface [polypeptide binding]; other site 1198676005671 conserved gate region; other site 1198676005672 ABC-ATPase subunit interface; other site 1198676005673 ABC-type metal ion transport system, ATPase component [Inorganic ion transport and metabolism]; Region: AbcC; COG1135 1198676005674 ATP-binding cassette domain of methionine transporter; Region: ABC_MetN_methionine_transporter; cd03258 1198676005675 Walker A/P-loop; other site 1198676005676 ATP binding site [chemical binding]; other site 1198676005677 Q-loop/lid; other site 1198676005678 ABC transporter signature motif; other site 1198676005679 Walker B; other site 1198676005680 D-loop; other site 1198676005681 H-loop/switch region; other site 1198676005682 NIL domain; Region: NIL; pfam09383 1198676005683 hypothetical protein; Provisional; Region: PRK06446 1198676005684 Uncharacterized M20 Dipeptidases; Region: M20_dipept_like_4; cd05681 1198676005685 metal binding site [ion binding]; metal-binding site 1198676005686 dimer interface [polypeptide binding]; other site 1198676005687 ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464 1198676005688 NLPA lipoprotein; Region: Lipoprotein_9; pfam03180 1198676005689 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 1198676005690 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1198676005691 substrate binding pocket [chemical binding]; other site 1198676005692 membrane-bound complex binding site; other site 1198676005693 hinge residues; other site 1198676005694 potential frameshift: common BLAST hit: gi|387787658|ref|YP_006252726.1| transposase 1198676005695 potential frameshift: common BLAST hit: gi|387787658|ref|YP_006252726.1| transposase 1198676005696 ABC-type bacteriocin/lantibiotic exporters, contain an N-terminal double-glycine peptidase domain [Defense mechanisms]; Region: SunT; COG2274 1198676005697 Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various bacteriocins (mostly non-lantibiotic); Region: Peptidase_C39_like; cl00296 1198676005698 putative active site [active] 1198676005699 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1198676005700 Walker A/P-loop; other site 1198676005701 ATP binding site [chemical binding]; other site 1198676005702 Q-loop/lid; other site 1198676005703 ABC transporter signature motif; other site 1198676005704 Walker B; other site 1198676005705 D-loop; other site 1198676005706 H-loop/switch region; other site 1198676005707 type 2 lantibiotic biosynthesis protein LanM; Region: lanti_2_LanM; TIGR03897 1198676005708 LanC-like proteins. LanC is the cyclase enzyme of the lanthionine synthetase. Lanthionine is a lantibiotic, a unique class of peptide antibiotics. They are ribosomally synthesized as a precursor peptide and then post-translationally modified to contain...; Region: LanC_like; cl04955 1198676005709 active site 1198676005710 zinc binding site [ion binding]; other site 1198676005711 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 1198676005712 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 1198676005713 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1198676005714 Walker A/P-loop; other site 1198676005715 ATP binding site [chemical binding]; other site 1198676005716 Q-loop/lid; other site 1198676005717 ABC transporter signature motif; other site 1198676005718 Walker B; other site 1198676005719 D-loop; other site 1198676005720 H-loop/switch region; other site 1198676005721 type 2 lantibiotic biosynthesis protein LanM; Region: lanti_2_LanM; TIGR03897 1198676005722 LanM-like proteins. LanM is a bifunctional enzyme, involved in the synthesis of class II lantibiotics. It is responsible for both the dehydration and the cyclization of the precursor-peptide during lantibiotic synthesis. The C-terminal domain shows...; Region: LanM-like; cd04792 1198676005723 active site 1198676005724 zinc binding site [ion binding]; other site 1198676005725 leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390 1198676005726 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 1198676005727 HIGH motif; other site 1198676005728 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 1198676005729 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 1198676005730 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 1198676005731 active site 1198676005732 KMSKS motif; other site 1198676005733 Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958 1198676005734 tRNA binding surface [nucleotide binding]; other site 1198676005735 Polyphosphate(polyP) polymerase domain of yeast vacuolar transport chaperone (VTC) proteins VTC-2, -3 and- 4, and similar proteins; Region: PolyPPase_VTC_like; cd07750 1198676005736 putative metal binding residues [ion binding]; other site 1198676005737 signature motif; other site 1198676005738 dimer interface [polypeptide binding]; other site 1198676005739 active site 1198676005740 polyP binding site; other site 1198676005741 substrate binding site [chemical binding]; other site 1198676005742 acceptor-phosphate pocket; other site 1198676005743 transcription antitermination protein NusG; Validated; Region: nusG; PRK05609 1198676005744 Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891 1198676005745 putative homodimer interface [polypeptide binding]; other site 1198676005746 NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091 1198676005747 heterodimer interface [polypeptide binding]; other site 1198676005748 homodimer interface [polypeptide binding]; other site 1198676005749 Preprotein translocase subunit SecE [Intracellular trafficking and secretion]; Region: SecE; COG0690 1198676005750 50S ribosomal protein L33; Validated; Region: rpmG; PRK00504 1198676005751 Membrane carboxypeptidase (penicillin-binding protein) [Cell envelope biogenesis, outer membrane]; Region: MrcB; COG0744 1198676005752 Transglycosylase; Region: Transgly; pfam00912 1198676005753 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 1198676005754 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 1198676005755 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 1198676005756 active site 1198676005757 Predicted membrane protein [Function unknown]; Region: COG4640 1198676005758 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 1198676005759 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 1198676005760 ring oligomerisation interface [polypeptide binding]; other site 1198676005761 ATP/Mg binding site [chemical binding]; other site 1198676005762 stacking interactions; other site 1198676005763 hinge regions; other site 1198676005764 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 1198676005765 oligomerisation interface [polypeptide binding]; other site 1198676005766 mobile loop; other site 1198676005767 roof hairpin; other site 1198676005768 PTS system mannose/fructose/sorbose family IID component; Region: EIID-AGA; pfam03613 1198676005769 Phosphotransferase system, mannose/fructose/N-acetylgalactosamine-specific component IIC [Carbohydrate transport and metabolism]; Region: ManY; COG3715 1198676005770 PTS system sorbose subfamily IIB component; Region: PTSIIB_sorb; pfam03830 1198676005771 active site 1198676005772 phosphorylation site [posttranslational modification] 1198676005773 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cl00025 1198676005774 active pocket/dimerization site; other site 1198676005775 active site 1198676005776 phosphorylation site [posttranslational modification] 1198676005777 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 1198676005778 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 1198676005779 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1198676005780 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1198676005781 active site 1198676005782 phosphorylation site [posttranslational modification] 1198676005783 intermolecular recognition site; other site 1198676005784 dimerization interface [polypeptide binding]; other site 1198676005785 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1198676005786 DNA binding residues [nucleotide binding] 1198676005787 dimerization interface [polypeptide binding]; other site 1198676005788 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 1198676005789 Histidine kinase; Region: HisKA_3; pfam07730 1198676005790 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 1198676005791 ATP binding site [chemical binding]; other site 1198676005792 Mg2+ binding site [ion binding]; other site 1198676005793 G-X-G motif; other site 1198676005794 Periplasmic sugar-binding domain of active transport systems that are members of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_sugar_binding_like; cd01536 1198676005795 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 1198676005796 ligand binding site [chemical binding]; other site 1198676005797 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 1198676005798 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 1198676005799 dimer interface [polypeptide binding]; other site 1198676005800 ssDNA binding site [nucleotide binding]; other site 1198676005801 tetramer (dimer of dimers) interface [polypeptide binding]; other site 1198676005802 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 1198676005803 active site residue [active] 1198676005804 MarR family; Region: MarR_2; cl17246 1198676005805 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1198676005806 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 1198676005807 putative tRNA-binding site [nucleotide binding]; other site 1198676005808 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 1198676005809 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 1198676005810 catalytic residues [active] 1198676005811 Cellulase M and related proteins [Carbohydrate transport and metabolism]; Region: FrvX; COG1363 1198676005812 glutamyl aminopeptidase; Region: glu_aminopep; TIGR03107 1198676005813 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232 1198676005814 pyrroline-5-carboxylate reductase; Reviewed; Region: PRK11880 1198676005815 CAAX protease self-immunity; Region: Abi; pfam02517 1198676005816 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1198676005817 non-specific DNA binding site [nucleotide binding]; other site 1198676005818 salt bridge; other site 1198676005819 sequence-specific DNA binding site [nucleotide binding]; other site 1198676005820 Transposase IS200 like; Region: Y1_Tnp; pfam01797 1198676005821 acetate kinase A/propionate kinase 2; Reviewed; Region: PRK00180 1198676005822 propionate/acetate kinase; Provisional; Region: PRK12379 1198676005823 Adenine-specific DNA methylase [DNA replication, recombination, and repair]; Region: COG0827 1198676005824 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1198676005825 S-adenosylmethionine binding site [chemical binding]; other site 1198676005826 Competence protein ComGF [Intracellular trafficking and secretion]; Region: ComGF; COG4940 1198676005827 Type II secretory pathway, pseudopilin PulG [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulG; COG2165 1198676005828 Type II secretory pathway pseudopilin; Region: PulG; pfam11773 1198676005829 Type II secretory pathway, pseudopilin PulG [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulG; COG2165 1198676005830 Competence protein ComGC [Intracellular trafficking and secretion]; Region: ComGC; COG4537 1198676005831 Type II secretory pathway, component PulF [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulF; COG1459 1198676005832 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 1198676005833 Type II/IV secretion system protein; Region: T2SE; pfam00437 1198676005834 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 1198676005835 Walker A motif; other site 1198676005836 ATP binding site [chemical binding]; other site 1198676005837 Walker B motif; other site 1198676005838 Protein of unknown function (DUF1033); Region: DUF1033; pfam06279 1198676005839 DNA-directed RNA polymerase subunit beta'; Provisional; Region: PRK00566 1198676005840 RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997 1198676005841 RNA polymerase I subunit A N-terminus; Region: RPOLA_N; smart00663 1198676005842 RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983 1198676005843 RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000 1198676005844 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 1198676005845 Rpb1 (beta') - Rpb6 (omega) interaction site [polypeptide binding]; other site 1198676005846 G-loop; other site 1198676005847 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 1198676005848 DNA binding site [nucleotide binding] 1198676005849 Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site 1198676005850 DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405 1198676005851 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585 1198676005852 RNA polymerase Rpb2, domain 2; Region: RNA_pol_Rpb2_2; pfam04561 1198676005853 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585 1198676005854 RNA polymerase beta subunit external 1 domain; Region: RNA_pol_Rpb2_45; pfam10385 1198676005855 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 1198676005856 RPB1 interaction site [polypeptide binding]; other site 1198676005857 RPB10 interaction site [polypeptide binding]; other site 1198676005858 RPB11 interaction site [polypeptide binding]; other site 1198676005859 RPB3 interaction site [polypeptide binding]; other site 1198676005860 RPB12 interaction site [polypeptide binding]; other site 1198676005861 Membrane carboxypeptidase (penicillin-binding protein) [Cell envelope biogenesis, outer membrane]; Region: MrcB; COG0744 1198676005862 Transglycosylase; Region: Transgly; pfam00912 1198676005863 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 1198676005864 tyrosyl-tRNA synthetase; Validated; Region: PRK05912 1198676005865 catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805 1198676005866 active site 1198676005867 HIGH motif; other site 1198676005868 dimer interface [polypeptide binding]; other site 1198676005869 KMSKS motif; other site 1198676005870 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1198676005871 RNA binding surface [nucleotide binding]; other site 1198676005872 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 1198676005873 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1198676005874 ABC-ATPase subunit interface; other site 1198676005875 dimer interface [polypeptide binding]; other site 1198676005876 putative PBP binding regions; other site 1198676005877 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 1198676005878 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 1198676005879 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1198676005880 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1198676005881 putative Zn2+ binding site [ion binding]; other site 1198676005882 putative DNA binding site [nucleotide binding]; other site 1198676005883 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: ipk; PRK00128 1198676005884 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 1198676005885 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 1198676005886 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 1198676005887 Glutamate-cysteine ligase family 2(GCS2); Region: GCS2; cl00954 1198676005888 50S ribosomal protein L17; Validated; Region: rplQ; PRK05591 1198676005889 DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182 1198676005890 N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928 1198676005891 alphaNTD homodimer interface [polypeptide binding]; other site 1198676005892 alphaNTD - beta interaction site [polypeptide binding]; other site 1198676005893 alphaNTD - beta' interaction site [polypeptide binding]; other site 1198676005894 Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118 1198676005895 30S ribosomal protein S11; Validated; Region: PRK05309 1198676005896 Ribosomal protein S13 [Translation, ribosomal structure and biogenesis]; Region: RpsM; COG0099 1198676005897 30S ribosomal protein S13; Region: bact_S13; TIGR03631 1198676005898 Ribosomal protein L36; Region: Ribosomal_L36; pfam00444 1198676005899 S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451 1198676005900 rRNA binding site [nucleotide binding]; other site 1198676005901 predicted 30S ribosome binding site; other site 1198676005902 adenylate kinase; Reviewed; Region: adk; PRK00279 1198676005903 Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428 1198676005904 AMP-binding site [chemical binding]; other site 1198676005905 ATP-AMP (Ap5A)-binding site [chemical binding]; other site 1198676005906 preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204 1198676005907 SecY translocase; Region: SecY; pfam00344 1198676005908 50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592 1198676005909 Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins that...; Region: Ribosomal_L30; cd01658 1198676005910 23S rRNA binding site [nucleotide binding]; other site 1198676005911 30S ribosomal protein S5; Validated; Region: rpsE; PRK00550 1198676005912 Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333 1198676005913 Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719 1198676005914 Ribosomal L18/L5e: L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432 1198676005915 5S rRNA interface [nucleotide binding]; other site 1198676005916 L27 interface [polypeptide binding]; other site 1198676005917 23S rRNA interface [nucleotide binding]; other site 1198676005918 L5 interface [polypeptide binding]; other site 1198676005919 50S ribosomal protein L6; Validated; Region: rplF; PRK05498 1198676005920 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 1198676005921 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 1198676005922 30S ribosomal protein S8; Validated; Region: rpsH; PRK00136 1198676005923 30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08061 1198676005924 50S ribosomal protein L5; Validated; Region: rplE; PRK00010 1198676005925 Ribosomal protein L5; Region: Ribosomal_L5; pfam00281 1198676005926 ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673 1198676005927 50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004 1198676005928 KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089 1198676005929 RNA binding site [nucleotide binding]; other site 1198676005930 50S ribosomal protein L14; Validated; Region: rplN; PRK05483 1198676005931 30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610 1198676005932 Ribosomal L29 protein/HIP. L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals. L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427 1198676005933 23S rRNA interface [nucleotide binding]; other site 1198676005934 putative translocon interaction site; other site 1198676005935 signal recognition particle (SRP54) interaction site; other site 1198676005936 L23 interface [polypeptide binding]; other site 1198676005937 trigger factor interaction site; other site 1198676005938 Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433 1198676005939 23S rRNA interface [nucleotide binding]; other site 1198676005940 5S rRNA interface [nucleotide binding]; other site 1198676005941 putative antibiotic binding site [chemical binding]; other site 1198676005942 L25 interface [polypeptide binding]; other site 1198676005943 L27 interface [polypeptide binding]; other site 1198676005944 30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310 1198676005945 K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3 is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel. The KH...; Region: 30S_S3_KH; cd02412 1198676005946 G-X-X-G motif; other site 1198676005947 Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189 1198676005948 Ribosomal protein L22/L17e. L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit. It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336 1198676005949 putative translocon binding site; other site 1198676005950 protein-rRNA interface [nucleotide binding]; other site 1198676005951 30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357 1198676005952 50S ribosomal protein L2; Validated; Region: rplB; PRK09374 1198676005953 Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181 1198676005954 Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947 1198676005955 50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738 1198676005956 50S ribosomal protein L4; Provisional; Region: rplD; PRK05319 1198676005957 50S ribosomal protein L3; Validated; Region: rplC; PRK00001 1198676005958 30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596 1198676005959 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1198676005960 SOS-response transcriptional repressors (RecA-mediated autopeptidases) [Transcription / Signal transduction mechanisms]; Region: LexA; COG1974 1198676005961 non-specific DNA binding site [nucleotide binding]; other site 1198676005962 salt bridge; other site 1198676005963 sequence-specific DNA binding site [nucleotide binding]; other site 1198676005964 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 1198676005965 Catalytic site [active] 1198676005966 KxYKxGKxW signal peptide; Region: KxYKxGKxW; TIGR03715 1198676005967 Glycosyl hydrolase family 68, includes levansucrase, beta-fructofuranosidase and inulosucrase; Region: GH68; cd08997 1198676005968 active site 1198676005969 ATP-binding subunits of Clp protease and DnaK/DnaJ chaperones [Posttranslational modification, protein turnover, chaperones]; Region: clpA; COG0542 1198676005970 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1198676005971 Walker A motif; other site 1198676005972 ATP binding site [chemical binding]; other site 1198676005973 Walker B motif; other site 1198676005974 arginine finger; other site 1198676005975 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1198676005976 Walker A motif; other site 1198676005977 ATP binding site [chemical binding]; other site 1198676005978 Walker B motif; other site 1198676005979 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 1198676005980 Firmicute transcriptional repressor of class III stress genes (CtsR); Region: CtsR; pfam05848 1198676005981 elongation factor Ts; Provisional; Region: tsf; PRK09377 1198676005982 UBA/TS-N domain; Region: UBA; pfam00627 1198676005983 Elongation factor TS; Region: EF_TS; pfam00889 1198676005984 Elongation factor TS; Region: EF_TS; pfam00889 1198676005985 Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425 1198676005986 rRNA interaction site [nucleotide binding]; other site 1198676005987 S8 interaction site; other site 1198676005988 putative laminin-1 binding site; other site 1198676005989 Predicted integral membrane protein [Function unknown]; Region: COG5617 1198676005990 Microcin C7 self-immunity protein determines resistance to exogenous microcin C7; Region: Peptidase_S66_mccF_like; cd07062 1198676005991 putative dimer interface [polypeptide binding]; other site 1198676005992 catalytic triad [active] 1198676005993 Predicted metalloendopeptidase [Posttranslational modification, protein turnover, chaperones]; Region: PepO; COG3590 1198676005994 Peptidase family M13 includes neprilysin, endothelin-converting enzyme I; Region: M13; cd08662 1198676005995 active site 1198676005996 Zn binding site [ion binding]; other site 1198676005997 alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403 1198676005998 Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333 1198676005999 Ca binding site [ion binding]; other site 1198676006000 active site 1198676006001 catalytic site [active] 1198676006002 Domain of unknown function (DUF3459); Region: DUF3459; pfam11941 1198676006003 PTS system, trehalose-specific IIBC component; Region: PTS-IIBC-Tre; TIGR01992 1198676006004 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 1198676006005 active site turn [active] 1198676006006 phosphorylation site [posttranslational modification] 1198676006007 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 1198676006008 Phosphotransferase system IIA components [Carbohydrate transport and metabolism]; Region: NagE; COG2190 1198676006009 HPr interaction site; other site 1198676006010 glycerol kinase (GK) interaction site [polypeptide binding]; other site 1198676006011 active site 1198676006012 phosphorylation site [posttranslational modification] 1198676006013 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1198676006014 DNA-binding site [nucleotide binding]; DNA binding site 1198676006015 trehalose operon repressor, B. subtilis-type; Region: trehalos_R_Bsub; TIGR02404 1198676006016 UTRA domain; Region: UTRA; pfam07702 1198676006017 Glycosyl hydrolase family 66; Region: Glyco_hydro_66; pfam13199 1198676006018 D-Tyrosyl-tRNAtyr deacylases; a class of tRNA-dependent hydrolases which are capable of hydrolyzing the ester bond of D-Tyrosyl-tRNA reducing the level of cellular D-Tyrosine while recycling the peptidyl-tRNA; found in bacteria and in eukaryotes but not...; Region: Dtyr_deacylase; cd00563 1198676006019 putative active site [active] 1198676006020 dimerization interface [polypeptide binding]; other site 1198676006021 putative tRNAtyr binding site [nucleotide binding]; other site 1198676006022 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 1198676006023 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1198676006024 Zn2+ binding site [ion binding]; other site 1198676006025 Mg2+ binding site [ion binding]; other site 1198676006026 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 1198676006027 synthetase active site [active] 1198676006028 NTP binding site [chemical binding]; other site 1198676006029 metal binding site [ion binding]; metal-binding site 1198676006030 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 1198676006031 ACT domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876 1198676006032 Streptococcus agalactiae RgfB, part of a putative two component signal transduction system, and related proteins; Region: RgfB-like; cd09079 1198676006033 putative catalytic site [active] 1198676006034 putative metal binding site [ion binding]; other site 1198676006035 putative phosphate binding site [ion binding]; other site 1198676006036 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 1198676006037 PTS system, IIBC component; Region: PTS-II-BC-unk1; TIGR02003 1198676006038 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 1198676006039 active site turn [active] 1198676006040 phosphorylation site [posttranslational modification] 1198676006041 Phosphotransferase system IIA components [Carbohydrate transport and metabolism]; Region: NagE; COG2190 1198676006042 HPr interaction site; other site 1198676006043 glycerol kinase (GK) interaction site [polypeptide binding]; other site 1198676006044 active site 1198676006045 phosphorylation site [posttranslational modification] 1198676006046 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1198676006047 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1198676006048 DNA binding site [nucleotide binding] 1198676006049 domain linker motif; other site 1198676006050 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1385 1198676006051 RNA methyltransferase, RsmE family; Region: TIGR00046 1198676006052 Ribosomal protein L11 methyltransferase (PrmA); Region: PrmA; pfam06325 1198676006053 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 1198676006054 Protein of unknown function (DUF3013); Region: DUF3013; pfam11217 1198676006055 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 1198676006056 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1198676006057 Coenzyme A binding pocket [chemical binding]; other site 1198676006058 recombination factor protein RarA; Reviewed; Region: PRK13342 1198676006059 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1198676006060 Walker A motif; other site 1198676006061 ATP binding site [chemical binding]; other site 1198676006062 Walker B motif; other site 1198676006063 arginine finger; other site 1198676006064 MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002 1198676006065 heavy metal-(Cd/Co/Hg/Pb/Zn)-translocating P-type ATPase; Region: ATPase-IB2_Cd; TIGR01512 1198676006066 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 1198676006067 Soluble P-type ATPase [General function prediction only]; Region: COG4087 1198676006068 Helix-Turn-Helix DNA binding domain of the BmrR transcription regulator; Region: HTH_BmrR; cd01107 1198676006069 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 1198676006070 DNA binding residues [nucleotide binding] 1198676006071 drug binding residues [chemical binding]; other site 1198676006072 dimer interface [polypeptide binding]; other site 1198676006073 Predicted membrane protein [Function unknown]; Region: COG2855 1198676006074 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1198676006075 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1198676006076 C-terminal substrate binding domain of LysR-type transcriptional regulator CysL, which activates the transcription of the cysJI operon encoding sulfite reductase, contains the type 2 periplasmic binding fold; Region: PBP2_CysL_like; cd08420 1198676006077 putative dimerization interface [polypeptide binding]; other site 1198676006078 ferrochelatase; Reviewed; Region: hemH; PRK00035 1198676006079 Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411 1198676006080 C-terminal domain interface [polypeptide binding]; other site 1198676006081 active site 1198676006082 Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419 1198676006083 active site 1198676006084 N-terminal domain interface [polypeptide binding]; other site 1198676006085 Bacterial membrane protein YfhO; Region: YfhO; pfam09586 1198676006086 UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247 1198676006087 UDP-glucose 4-epimerase; Region: PLN02240 1198676006088 NAD binding site [chemical binding]; other site 1198676006089 homodimer interface [polypeptide binding]; other site 1198676006090 active site 1198676006091 substrate binding site [chemical binding]; other site 1198676006092 Bacterial membrane protein YfhO; Region: YfhO; pfam09586 1198676006093 undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714 1198676006094 Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187 1198676006095 Ligand binding site; other site 1198676006096 Putative Catalytic site; other site 1198676006097 DXD motif; other site 1198676006098 zinc transporter ZupT; Provisional; Region: PRK04201 1198676006099 ZIP Zinc transporter; Region: Zip; pfam02535 1198676006100 hypothetical protein; Validated; Region: PRK02101 1198676006101 4Fe-4S single cluster domain; Region: Fer4_12; pfam13353 1198676006102 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1198676006103 FeS/SAM binding site; other site 1198676006104 Predicted acetyltransferase [General function prediction only]; Region: COG3981 1198676006105 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 1198676006106 Coenzyme A binding pocket [chemical binding]; other site 1198676006107 anaerobic ribonucleoside triphosphate reductase; Provisional; Region: PRK09263 1198676006108 ATP cone domain; Region: ATP-cone; pfam03477 1198676006109 Class III ribonucleotide reductase; Region: RNR_III; cd01675 1198676006110 effector binding site; other site 1198676006111 active site 1198676006112 Zn binding site [ion binding]; other site 1198676006113 glycine loop; other site 1198676006114 Predicted membrane protein (DUF2079); Region: DUF2079; pfam09852 1198676006115 hypothetical protein; Provisional; Region: PRK13678 1198676006116 Holliday junction resolvase-like protein; Reviewed; Region: PRK00109 1198676006117 hypothetical protein; Provisional; Region: PRK05473 1198676006118 LytTr DNA-binding domain; Region: LytTR; pfam04397 1198676006119 Protein of unknown function (DUF3021); Region: DUF3021; pfam11457 1198676006120 Arsenate Reductase (ArsC) family, Spx subfamily; Spx is a unique RNA polymerase (RNAP)-binding protein present in bacilli and some mollicutes. It inhibits transcription by binding to the C-terminal domain of the alpha subunit of RNAP, disrupting complex...; Region: ArsC_Spx; cd03032 1198676006121 ArsC family; Region: ArsC; pfam03960 1198676006122 putative catalytic residues [active] 1198676006123 thiol/disulfide switch; other site 1198676006124 recombinase A; Provisional; Region: recA; PRK09354 1198676006125 RecA is a bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response. RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983 1198676006126 hexamer interface [polypeptide binding]; other site 1198676006127 Walker A motif; other site 1198676006128 ATP binding site [chemical binding]; other site 1198676006129 Walker B motif; other site 1198676006130 competence damage-inducible protein A; Provisional; Region: PRK00549 1198676006131 Competence-damaged protein. CinA is the first gene in the competence- inducible (cin) operon and is thought to be specifically required at some stage in the process of transformation. This domain is closely related to a domain, found in a variety of...; Region: cinA; cd00885 1198676006132 putative MPT binding site; other site 1198676006133 Uncharacterized protein (competence- and mitomycin-induced) [General function prediction only]; Region: CinA; COG1546 1198676006134 Methyladenine glycosylase; Region: Adenine_glyco; pfam03352 1198676006135 Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116 1198676006136 RuvA N terminal domain; Region: RuvA_N; pfam01330 1198676006137 DNA mismatch repair protein; Reviewed; Region: mutL; PRK00095 1198676006138 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1198676006139 ATP binding site [chemical binding]; other site 1198676006140 Mg2+ binding site [ion binding]; other site 1198676006141 G-X-G motif; other site 1198676006142 MutL_Trans: transducer domain, having a ribosomal S5 domain 2-like fold, conserved in the C-terminal domain of DNA mismatch repair (MutL/MLH1/PMS2) family. This transducer domain is homologous to the second domain of the DNA gyrase B subunit, which is...; Region: MutL_Trans; cd00782 1198676006143 ATP binding site [chemical binding]; other site 1198676006144 MutL C terminal dimerisation domain; Region: MutL_C; pfam08676 1198676006145 DNA mismatch repair protein MutS; Provisional; Region: PRK05399 1198676006146 MutS domain I; Region: MutS_I; pfam01624 1198676006147 MutS domain II; Region: MutS_II; pfam05188 1198676006148 MutS domain III; Region: MutS_III; pfam05192 1198676006149 ATP-binding cassette domain of MutS1 homolog; Region: ABC_MutS1; cd03284 1198676006150 Walker A/P-loop; other site 1198676006151 ATP binding site [chemical binding]; other site 1198676006152 Q-loop/lid; other site 1198676006153 ABC transporter signature motif; other site 1198676006154 Walker B; other site 1198676006155 D-loop; other site 1198676006156 H-loop/switch region; other site 1198676006157 Protein of unknown function (DUF964); Region: DUF964; cl01483 1198676006158 Arginine repressor, DNA binding domain; Region: Arg_repressor; pfam01316 1198676006159 arginine repressor; Region: argR_whole; TIGR01529 1198676006160 Arginine repressor, C-terminal domain; Region: Arg_repressor_C; pfam02863 1198676006161 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 1198676006162 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 1198676006163 ligand binding site [chemical binding]; other site 1198676006164 flexible hinge region; other site 1198676006165 B3/4 domain; Region: B3_4; pfam03483 1198676006166 Arginine repressor, C-terminal domain; Region: Arg_repressor_C; pfam02863 1198676006167 arginyl-tRNA synthetase; Reviewed; Region: PRK12451 1198676006168 Arginyl tRNA synthetase N terminal dom; Region: Arg_tRNA_synt_N; smart01016 1198676006169 catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671 1198676006170 active site 1198676006171 HIGH motif; other site 1198676006172 KMSK motif region; other site 1198676006173 Anticodon-binding domain of arginyl tRNA synthetases; Region: Anticodon_Ia_Arg; cd07956 1198676006174 tRNA binding surface [nucleotide binding]; other site 1198676006175 anticodon binding site; other site 1198676006176 Uncharacterized conserved protein [Function unknown]; Region: COG1284 1198676006177 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 1198676006178 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 1198676006179 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 1198676006180 Uncharacterized conserved protein [Function unknown]; Region: COG1284 1198676006181 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 1198676006182 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 1198676006183 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 1198676006184 aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476 1198676006185 EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317 1198676006186 dimer interface [polypeptide binding]; other site 1198676006187 anticodon binding site; other site 1198676006188 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777 1198676006189 homodimer interface [polypeptide binding]; other site 1198676006190 motif 1; other site 1198676006191 active site 1198676006192 motif 2; other site 1198676006193 GAD domain; Region: GAD; pfam02938 1198676006194 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777 1198676006195 motif 3; other site 1198676006196 histidyl-tRNA synthetase; Reviewed; Region: hisS; PRK00037 1198676006197 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 1198676006198 dimer interface [polypeptide binding]; other site 1198676006199 motif 1; other site 1198676006200 active site 1198676006201 motif 2; other site 1198676006202 HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859 1198676006203 anticodon binding site; other site 1198676006204 Amino acid permease; Region: AA_permease_2; pfam13520 1198676006205 50S ribosomal protein L32; Validated; Region: rpmF; PRK01110 1198676006206 50S ribosomal protein L33; Validated; Region: rpmG; PRK00595 1198676006207 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1198676006208 dimerization interface [polypeptide binding]; other site 1198676006209 putative DNA binding site [nucleotide binding]; other site 1198676006210 putative Zn2+ binding site [ion binding]; other site 1198676006211 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1198676006212 putative substrate translocation pore; other site 1198676006213 KxYKxGKxW signal peptide; Region: KxYKxGKxW; TIGR03715 1198676006214 glucan-binding repeat; Region: glucan_65_rpt; TIGR04035 1198676006215 glucan-binding repeat; Region: glucan_65_rpt; TIGR04035 1198676006216 glucan-binding repeat; Region: glucan_65_rpt; TIGR04035 1198676006217 glucan-binding repeat; Region: glucan_65_rpt; TIGR04035 1198676006218 glucan-binding repeat; Region: glucan_65_rpt; TIGR04035 1198676006219 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1198676006220 catalytic core [active] 1198676006221 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 1198676006222 Helix-Turn-Helix DNA binding domain of the MerR-like transcription regulators YyaN and YraB; Region: HTH_YyaN; cd01109 1198676006223 DNA binding residues [nucleotide binding] 1198676006224 putative dimer interface [polypeptide binding]; other site 1198676006225 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 1198676006226 classical (c) SDRs; Region: SDR_c; cd05233 1198676006227 NAD(P) binding site [chemical binding]; other site 1198676006228 active site 1198676006229 ABC-type proline/glycine betaine transport systems, ATPase components [Amino acid transport and metabolism]; Region: OpuBA; COG1125 1198676006230 ATP-binding cassette domain of the osmoprotectant transporter; Region: ABC_OpuCA_Osmoprotection; cd03295 1198676006231 Walker A/P-loop; other site 1198676006232 ATP binding site [chemical binding]; other site 1198676006233 Q-loop/lid; other site 1198676006234 ABC transporter signature motif; other site 1198676006235 Walker B; other site 1198676006236 D-loop; other site 1198676006237 H-loop/switch region; other site 1198676006238 FOG: CBS domain [General function prediction only]; Region: COG0517 1198676006239 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in association with the ABC transporter OpuCA. OpuCA is the ATP binding component of a bacterial solute transporter that serves a protective role to cells growing...; Region: CBS_pair_ABC_OpuCA_assoc2; cd04583 1198676006240 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1198676006241 dimer interface [polypeptide binding]; other site 1198676006242 conserved gate region; other site 1198676006243 putative PBP binding loops; other site 1198676006244 ABC-ATPase subunit interface; other site 1198676006245 ABC-type proline/glycine betaine transport systems, periplasmic components [Amino acid transport and metabolism]; Region: ProX; cl17891 1198676006246 Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069 1198676006247 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1198676006248 dimer interface [polypeptide binding]; other site 1198676006249 conserved gate region; other site 1198676006250 ABC-ATPase subunit interface; other site 1198676006251 Alkyladenine DNA glycosylase catalyzes the first step in base excision repair; Region: AAG; cd00540 1198676006252 active site 1198676006253 DNA binding site [nucleotide binding] 1198676006254 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2350 1198676006255 Predicted transcriptional regulators [Transcription]; Region: COG1733 1198676006256 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 1198676006257 Phosphorylase superfamily; Region: PNP_UDP_1; pfam01048 1198676006258 NAD-dependent aldehyde dehydrogenases [Energy production and conversion]; Region: PutA; COG1012 1198676006259 Mycobacterium tuberculosis succinate-semialdehyde dehydrogenase 1-like; Region: ALDH_SSADH1_GabD1; cd07100 1198676006260 NAD(P) binding site [chemical binding]; other site 1198676006261 catalytic residues [active] 1198676006262 dihydroxy-acid dehydratase; Provisional; Region: PRK00911 1198676006263 Domain of unknown function DUF59; Region: DUF59; cl00941 1198676006264 C4-dicarboxylate transporters of the Tellurite-resistance/Dicarboxylate Transporter (TDT) family; Region: TDT_C4-dicarb_trans; cd09325 1198676006265 gating phenylalanine in ion channel; other site 1198676006266 Predicted membrane protein [Function unknown]; Region: COG1511 1198676006267 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061 1198676006268 X-X-X-Leu-X-X-Gly heptad repeats; Region: xxxLxxG_by_4; TIGR03057 1198676006269 YhgE/Pip C-terminal domain; Region: pip_yhgE_Cterm; TIGR03062 1198676006270 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1198676006271 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1198676006272 30S ribosomal protein S4; Validated; Region: rpsD; PRK05327 1198676006273 Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163 1198676006274 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1198676006275 RNA binding surface [nucleotide binding]; other site 1198676006276 Uncharacterized protein conserved in bacteria [Function unknown]; Region: Veg; COG4466 1198676006277 replicative DNA helicase; Provisional; Region: PRK05748 1198676006278 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 1198676006279 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 1198676006280 Walker A motif; other site 1198676006281 ATP binding site [chemical binding]; other site 1198676006282 Walker B motif; other site 1198676006283 DNA binding loops [nucleotide binding] 1198676006284 50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137 1198676006285 Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281 1198676006286 Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948 1198676006287 Predicted signaling protein consisting of a modified GGDEF domain and a DHH domain [Signal transduction mechanisms]; Region: COG3887 1198676006288 DHH family; Region: DHH; pfam01368 1198676006289 DHHA1 domain; Region: DHHA1; pfam02272 1198676006290 tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA; Validated; Region: PRK05192 1198676006291 tRNA:m(5)U-54 methyltransferase; Region: gid_trmFO; TIGR00137 1198676006292 GidA associated domain 3; Region: GIDA_assoc_3; pfam13932 1198676006293 hypothetical protein; Provisional; Region: PRK09273 1198676006294 Ribose/Galactose Isomerase; Region: LacAB_rpiB; pfam02502 1198676006295 Predicted tRNA(5-methylaminomethyl-2-thiouridylate) methyltransferase, contains the PP-loop ATPase domain [Translation, ribosomal structure and biogenesis]; Region: TrmU; COG0482 1198676006296 tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998 1198676006297 Transglycosylase-like domain; Region: Transglycosylas; pfam06737 1198676006298 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1198676006299 ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619 1198676006300 cobalt transporter ATP-binding subunit; Provisional; Region: cbiO; PRK13649 1198676006301 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 1198676006302 Walker A/P-loop; other site 1198676006303 ATP binding site [chemical binding]; other site 1198676006304 Q-loop/lid; other site 1198676006305 ABC transporter signature motif; other site 1198676006306 Walker B; other site 1198676006307 D-loop; other site 1198676006308 H-loop/switch region; other site 1198676006309 cobalt transporter ATP-binding subunit; Provisional; Region: cbiO; PRK13650 1198676006310 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 1198676006311 Walker A/P-loop; other site 1198676006312 ATP binding site [chemical binding]; other site 1198676006313 Q-loop/lid; other site 1198676006314 ABC transporter signature motif; other site 1198676006315 Walker B; other site 1198676006316 D-loop; other site 1198676006317 H-loop/switch region; other site 1198676006318 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453 1198676006319 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1198676006320 non-specific DNA binding site [nucleotide binding]; other site 1198676006321 salt bridge; other site 1198676006322 sequence-specific DNA binding site [nucleotide binding]; other site 1198676006323 Domain of unknown function (DUF4115); Region: DUF4115; pfam13464 1198676006324 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 1198676006325 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 1198676006326 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 1198676006327 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 1198676006328 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 1198676006329 S4 domain protein YaaA; Region: YaaA_near_RecF; TIGR02988 1198676006330 recombination protein F; Reviewed; Region: recF; PRK00064 1198676006331 ATP-binding cassette domain of RecF; Region: ABC_RecF; cd03242 1198676006332 Walker A/P-loop; other site 1198676006333 ATP binding site [chemical binding]; other site 1198676006334 Q-loop/lid; other site 1198676006335 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1198676006336 ABC transporter signature motif; other site 1198676006337 Walker B; other site 1198676006338 D-loop; other site 1198676006339 H-loop/switch region; other site 1198676006340 inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567 1198676006341 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 1198676006342 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein. IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a...; Region: CBS_pair_IMPDH; cd04601 1198676006343 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 1198676006344 active site 1198676006345 tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282 1198676006346 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 1198676006347 active site 1198676006348 HIGH motif; other site 1198676006349 dimer interface [polypeptide binding]; other site 1198676006350 KMSKS motif; other site 1198676006351 ABC transporter ATP-binding protein; Provisional; Region: PRK15064 1198676006352 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1198676006353 Walker A/P-loop; other site 1198676006354 ATP binding site [chemical binding]; other site 1198676006355 Q-loop/lid; other site 1198676006356 ABC transporter signature motif; other site 1198676006357 Walker B; other site 1198676006358 D-loop; other site 1198676006359 H-loop/switch region; other site 1198676006360 ABC transporter; Region: ABC_tran_2; pfam12848 1198676006361 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1198676006362 Bacterial membrane protein YfhO; Region: YfhO; pfam09586 1198676006363 Protein of unknown function (DUF1275); Region: DUF1275; pfam06912 1198676006364 rRNA large subunit methyltransferase; Provisional; Region: PRK00103 1198676006365 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 1198676006366 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 1198676006367 protein binding site [polypeptide binding]; other site 1198676006368 ParB/RepB/Spo0J family partition protein; Region: parB_part; TIGR00180 1198676006369 ParB-like nuclease domain; Region: ParBc; pfam02195 1198676006370 Sugar-specific transcriptional regulator TrmB; Region: TrmB; cl17775 1198676006371 chromosomal replication initiation protein; Reviewed; Region: dnaA; PRK00149