-- dump date 20140620_083046 -- class Genbank::misc_feature -- table misc_feature_note -- id note 1155071000001 chromosomal replication initiation protein; Reviewed; Region: dnaA; PRK00149 1155071000002 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1155071000003 Walker A motif; other site 1155071000004 ATP binding site [chemical binding]; other site 1155071000005 Walker B motif; other site 1155071000006 arginine finger; other site 1155071000007 C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571 1155071000008 DnaA box-binding interface [nucleotide binding]; other site 1155071000009 DNA polymerase III subunit beta; Validated; Region: PRK05643 1155071000010 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140 1155071000011 putative DNA binding surface [nucleotide binding]; other site 1155071000012 dimer interface [polypeptide binding]; other site 1155071000013 beta-clamp/clamp loader binding surface; other site 1155071000014 beta-clamp/translesion DNA polymerase binding surface; other site 1155071000015 Bacterial protein of unknown function (DUF951); Region: DUF951; pfam06107 1155071000016 GTP-binding protein YchF; Reviewed; Region: PRK09601 1155071000017 YchF GTPase; Region: YchF; cd01900 1155071000018 G1 box; other site 1155071000019 GTP/Mg2+ binding site [chemical binding]; other site 1155071000020 Switch I region; other site 1155071000021 G2 box; other site 1155071000022 Switch II region; other site 1155071000023 G3 box; other site 1155071000024 G4 box; other site 1155071000025 G5 box; other site 1155071000026 TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867 1155071000027 Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462 1155071000028 putative active site [active] 1155071000029 catalytic residue [active] 1155071000030 Transcription-repair coupling factor (superfamily II helicase) [DNA replication, recombination, and repair / Transcription]; Region: Mfd; COG1197 1155071000031 CarD-like/TRCF domain; Region: CarD_TRCF; smart01058 1155071000032 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1155071000033 ATP binding site [chemical binding]; other site 1155071000034 putative Mg++ binding site [ion binding]; other site 1155071000035 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1155071000036 nucleotide binding region [chemical binding]; other site 1155071000037 ATP-binding site [chemical binding]; other site 1155071000038 This domain is found in proteins necessary for strand-specific repair in DNA such as TRCF in Escherichia coli; Region: TRCF; smart00982 1155071000039 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1155071000040 RNA binding surface [nucleotide binding]; other site 1155071000041 Septum formation initiator [Cell division and chromosome partitioning]; Region: COG2919 1155071000042 Septum formation initiator; Region: DivIC; pfam04977 1155071000043 Beta-lactamase enzyme family; Region: Beta-lactamase2; pfam13354 1155071000044 tRNA(Ile)-lysidine synthase MesJ [Cell cycle control, cell division, chromosome partitioning]; Region: MesJ; COG0037 1155071000045 N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992 1155071000046 Ligand Binding Site [chemical binding]; other site 1155071000047 TilS substrate C-terminal domain; Region: TilS_C; smart00977 1155071000048 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1155071000049 active site 1155071000050 ATP-dependent Zn proteases [Posttranslational modification, protein turnover, chaperones]; Region: HflB; COG0465 1155071000051 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1155071000052 Walker A motif; other site 1155071000053 ATP binding site [chemical binding]; other site 1155071000054 Walker B motif; other site 1155071000055 arginine finger; other site 1155071000056 Peptidase family M41; Region: Peptidase_M41; pfam01434 1155071000057 amino acid transporter; Region: 2A0306; TIGR00909 1155071000058 C-terminus of AA_permease; Region: AA_permease_C; pfam13906 1155071000059 rod shape-determining protein MreC; Provisional; Region: PRK13922 1155071000060 rod shape-determining protein MreC; Region: MreC; pfam04085 1155071000061 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3883 1155071000062 Surface antigen [General function prediction only]; Region: COG3942 1155071000063 CHAP domain; Region: CHAP; pfam05257 1155071000064 ribose-phosphate pyrophosphokinase; Provisional; Region: PRK02269 1155071000065 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 1155071000066 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1155071000067 active site 1155071000068 aromatic amino acid aminotransferase; Validated; Region: PRK07309 1155071000069 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1155071000070 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1155071000071 homodimer interface [polypeptide binding]; other site 1155071000072 catalytic residue [active] 1155071000073 Recombination protein O N terminal; Region: RecO_N; pfam11967 1155071000074 DNA repair protein RecO; Region: reco; TIGR00613 1155071000075 Recombination protein O C terminal; Region: RecO_C; pfam02565 1155071000076 putative phosphate acyltransferase; Provisional; Region: PRK05331 1155071000077 acyl carrier protein; Provisional; Region: PRK12449 1155071000078 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 1155071000079 ATP-binding cassette domain of multidrug resistance protein-like transporters; Region: ABCC_MRP_Like; cd03228 1155071000080 Walker A/P-loop; other site 1155071000081 ATP binding site [chemical binding]; other site 1155071000082 Q-loop/lid; other site 1155071000083 ABC transporter signature motif; other site 1155071000084 Walker B; other site 1155071000085 D-loop; other site 1155071000086 H-loop/switch region; other site 1155071000087 phosphoribosylaminoimidazole-succinocarboxamide synthase; Reviewed; Region: PRK09362 1155071000088 bacterial and archaeal 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_PurC; cd01415 1155071000089 ATP binding site [chemical binding]; other site 1155071000090 active site 1155071000091 substrate binding site [chemical binding]; other site 1155071000092 phosphoribosylformylglycinamidine synthase, clade II; Region: FGAM-synthase; TIGR01857 1155071000093 AIR (aminoimidazole ribonucleotide) synthase related protein. This family includes Hydrogen expression/formation protein HypE, AIR synthases, FGAM (formylglycinamidine ribonucleotide) synthase and Selenophosphate synthetase (SelD). The N-terminal domain...; Region: PurM-like; cl10019 1155071000094 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203 1155071000095 dimerization interface [polypeptide binding]; other site 1155071000096 ATP binding site [chemical binding]; other site 1155071000097 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat2; cd02204 1155071000098 dimerization interface [polypeptide binding]; other site 1155071000099 ATP binding site [chemical binding]; other site 1155071000100 Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740 1155071000101 putative active site [active] 1155071000102 catalytic triad [active] 1155071000103 A new structural DNA glycosylase; Region: AlkD_like; cl11434 1155071000104 HEAT repeats; Region: HEAT_2; pfam13646 1155071000105 active site 1155071000106 amidophosphoribosyltransferase; Provisional; Region: PRK07272 1155071000107 Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715 1155071000108 active site 1155071000109 tetramer interface [polypeptide binding]; other site 1155071000110 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1155071000111 active site 1155071000112 phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385 1155071000113 PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196 1155071000114 dimerization interface [polypeptide binding]; other site 1155071000115 putative ATP binding site [chemical binding]; other site 1155071000116 phosphoribosylglycinamide formyltransferase; Reviewed; Region: purN; PRK05647 1155071000117 Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645 1155071000118 active site 1155071000119 substrate binding site [chemical binding]; other site 1155071000120 cosubstrate binding site; other site 1155071000121 catalytic site [active] 1155071000122 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881 1155071000123 Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal ATIC formylase domain that formylates...; Region: IMPCH; cd01421 1155071000124 purine monophosphate binding site [chemical binding]; other site 1155071000125 dimer interface [polypeptide binding]; other site 1155071000126 putative catalytic residues [active] 1155071000127 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; smart00798 1155071000128 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; cl03362 1155071000129 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1155071000130 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1155071000131 Protein of unknown function with HXXEE motif; Region: HXXEE; pfam13787 1155071000132 Plasmid stabilisation system protein; Region: Plasmid_stabil; cl17483 1155071000133 Abi-like protein; Region: Abi_2; pfam07751 1155071000134 phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885 1155071000135 Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844 1155071000136 Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Region: GARS_A; pfam01071 1155071000137 Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843 1155071000138 ATP-grasp domain; Region: ATP-grasp_4; cl17255 1155071000139 Phosphoribosylcarboxyaminoimidazole (NCAIR) mutase [Nucleotide transport and metabolism]; Region: PurE; COG0041 1155071000140 phosphoribosylaminoimidazole carboxylase ATPase subunit; Reviewed; Region: PRK06019 1155071000141 ATP-grasp domain; Region: ATP-grasp; pfam02222 1155071000142 disrupted protein 1155071000143 aspartate racemase; Region: asp_race; TIGR00035 1155071000144 Aspartate racemase [Cell envelope biogenesis, outer membrane]; Region: RacX; COG1794 1155071000145 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cd07812 1155071000146 hydrophobic ligand binding site; other site 1155071000147 adenylosuccinate lyase; Provisional; Region: PRK07492 1155071000148 Adenylsuccinate lyase (ASL)_subgroup 1; Region: Adenylsuccinate_lyase_1; cd01360 1155071000149 tetramer interface [polypeptide binding]; other site 1155071000150 active site 1155071000151 DNA alkylation repair enzyme; Region: DNA_alkylation; pfam08713 1155071000152 A new structural DNA glycosylase containing HEAT-like repeats; Region: AlkD_like_1; cd07064 1155071000153 active site 1155071000154 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1155071000155 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1155071000156 non-specific DNA binding site [nucleotide binding]; other site 1155071000157 salt bridge; other site 1155071000158 sequence-specific DNA binding site [nucleotide binding]; other site 1155071000159 Domain of unknown function (DUF4353); Region: DUF4353; pfam14262 1155071000160 Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080 1155071000161 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1155071000162 Walker A motif; other site 1155071000163 ATP binding site [chemical binding]; other site 1155071000164 Walker B motif; other site 1155071000165 arginine finger; other site 1155071000166 Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491 1155071000167 Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394 1155071000168 Low molecular weight phosphatase family; Region: LMWPc; cd00115 1155071000169 active site 1155071000170 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4642 1155071000171 Acyltransferase family; Region: Acyl_transf_3; pfam01757 1155071000172 glucans biosynthesis protein; Provisional; Region: opgC; PRK03854 1155071000173 yrhL-like subfamily of SGNH-hydrolases, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase_yrhL_like; cd01840 1155071000174 catalytic triad [active] 1155071000175 catalytic triad [active] 1155071000176 oxyanion hole [active] 1155071000177 Threonine synthase catalyzes the final step of threonine biosynthesis. The conversion of O-phosphohomoserine into threonine and inorganic phosphate is pyridoxal 5'-phosphate dependent. The Thr-synth_1 CD includes members from higher plants; Region: Thr-synth_2; cd01560 1155071000178 Threonine synthase [Amino acid transport and metabolism]; Region: ThrC; COG0498 1155071000179 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1155071000180 catalytic residue [active] 1155071000181 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 1155071000182 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Thermotoga marina NorM; Region: MATE_NorM_like; cd13137 1155071000183 ACT domain proteins similar to the yet uncharacterized Streptococcus pneumoniae ACT domain protein; Region: ACT_1ZPV; cd04872 1155071000184 Uncharacterized proteins with similarity to Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL_like_DUF711; cd08025 1155071000185 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1155071000186 catalytic core [active] 1155071000187 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1155071000188 D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: VanY; COG1876 1155071000189 D-alanyl-D-alanine carboxypeptidase; Region: VanY; pfam02557 1155071000190 Muramidase (flagellum-specific) [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FlgJ; COG1705 1155071000191 KxYKxGKxW signal peptide; Region: KxYKxGKxW; TIGR03715 1155071000192 Domain of Unknown Function (DUF1080); Region: DUF1080; pfam06439 1155071000193 Cadherin-like beta sandwich domain; Region: Cadherin-like; pfam12733 1155071000194 Glycosyl hydrolases family 32; Region: Glyco_32; smart00640 1155071000195 Glycosyl hydrolase family 32, beta-fructosidases; Region: GH32_B_Fructosidase; cd08996 1155071000196 substrate binding [chemical binding]; other site 1155071000197 active site 1155071000198 Glycosyl hydrolases family 32 C terminal; Region: Glyco_hydro_32C; pfam08244 1155071000199 Bacterial Ig-like domain (group 2); Region: Big_2; pfam02368 1155071000200 Laminin G domain; Region: Laminin_G_2; pfam02210 1155071000201 Glycosyl hydrolases family 32; Region: Glyco_32; smart00640 1155071000202 Glycosyl hydrolase family 32, beta-fructosidases; Region: GH32_B_Fructosidase; cd08996 1155071000203 substrate binding [chemical binding]; other site 1155071000204 active site 1155071000205 heat-inducible transcription repressor; Provisional; Region: hrcA; PRK00082 1155071000206 Winged helix-turn-helix transcription repressor, HrcA DNA-binding; Region: HrcA_DNA-bdg; pfam03444 1155071000207 GrpE; Region: GrpE; pfam01025 1155071000208 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446 1155071000209 dimer interface [polypeptide binding]; other site 1155071000210 hsp70 (ATPase domain) interactions [polypeptide binding]; other site 1155071000211 molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290 1155071000212 Nucleotide-binding domain of human HSPA9 and similar proteins; Region: HSPA9-Ssq1-like_NBD; cd10234 1155071000213 nucleotide binding site [chemical binding]; other site 1155071000214 NEF interaction site [polypeptide binding]; other site 1155071000215 SBD interface [polypeptide binding]; other site 1155071000216 chaperone protein DnaJ; Provisional; Region: PRK14276 1155071000217 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 1155071000218 HSP70 interaction site [polypeptide binding]; other site 1155071000219 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cl03262 1155071000220 substrate binding site [polypeptide binding]; other site 1155071000221 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 1155071000222 Zn binding sites [ion binding]; other site 1155071000223 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 1155071000224 dimer interface [polypeptide binding]; other site 1155071000225 Eukaryotic and bacterial pseudouridine synthases similar to E. coli TruA; Region: PseudoU_synth_EcTruA; cd02570 1155071000226 tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021 1155071000227 active site 1155071000228 dimerization interface 3.5A [polypeptide binding]; other site 1155071000229 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 1155071000230 dimer interface [polypeptide binding]; other site 1155071000231 substrate binding site [chemical binding]; other site 1155071000232 ATP binding site [chemical binding]; other site 1155071000233 ECF-type riboflavin transporter, S component; Region: ECF-ribofla_trS; pfam07155 1155071000234 hypothetical protein; Provisional; Region: PRK13690 1155071000235 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 1155071000236 Mechanosensitive ion channel; Region: MS_channel; pfam00924 1155071000237 Formate/nitrite transporter; Region: Form_Nir_trans; cl00927 1155071000238 trigger factor; Provisional; Region: tig; PRK01490 1155071000239 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 1155071000240 Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698 1155071000241 DNA-directed RNA polymerase delta subunit; Region: RNA_pol_delta; pfam05066 1155071000242 CTP synthetase; Validated; Region: pyrG; PRK05380 1155071000243 CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113 1155071000244 Catalytic site [active] 1155071000245 active site 1155071000246 UTP binding site [chemical binding]; other site 1155071000247 Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746 1155071000248 active site 1155071000249 putative oxyanion hole; other site 1155071000250 catalytic triad [active] 1155071000251 fructose-bisphosphate aldolase; Provisional; Region: PRK09197 1155071000252 Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947 1155071000253 intersubunit interface [polypeptide binding]; other site 1155071000254 active site 1155071000255 zinc binding site [ion binding]; other site 1155071000256 Na+ binding site [ion binding]; other site 1155071000257 PTS system sorbose subfamily IIB component; Region: PTSIIB_sorb; pfam03830 1155071000258 active site 1155071000259 phosphorylation site [posttranslational modification] 1155071000260 PTS system sorbose-specific iic component; Region: EII-Sor; pfam03609 1155071000261 PTS system mannose/fructose/sorbose family IID component; Region: EIID-AGA; pfam03613 1155071000262 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cl00025 1155071000263 active pocket/dimerization site; other site 1155071000264 active site 1155071000265 phosphorylation site [posttranslational modification] 1155071000266 Alpha-glucosidases, family 31 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: COG1501 1155071000267 This family represents an uncharacterized glycosyl hydrolase family 31 (GH31) enzyme found in bacteria and eukaryotes that is related to the XylS xylosidase of Sulfolobus solfataricus. Alpha-xylosidases catalyze the release of an alpha-xylose residue...; Region: GH31_xylosidase_XylS-like; cd06595 1155071000268 putative active site [active] 1155071000269 putative catalytic site [active] 1155071000270 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1155071000271 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1155071000272 DNA binding site [nucleotide binding] 1155071000273 domain linker motif; other site 1155071000274 Ligand binding domain of the lacI-like transcription regulator from a novel metal-reducing bacterium Alkaliphilus Metalliredigens (strain Qymf) and its close homologs; Region: PBP1_Qymf_like; cd06291 1155071000275 dimerization interface [polypeptide binding]; other site 1155071000276 ligand binding site [chemical binding]; other site 1155071000277 sodium binding site [ion binding]; other site 1155071000278 Transposase DDE domain; Region: DDE_Tnp_1_3; pfam13612 1155071000279 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1155071000280 S-adenosylmethionine binding site [chemical binding]; other site 1155071000281 H+ Antiporter protein; Region: 2A0121; TIGR00900 1155071000282 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1155071000283 non-specific DNA binding site [nucleotide binding]; other site 1155071000284 salt bridge; other site 1155071000285 sequence-specific DNA binding site [nucleotide binding]; other site 1155071000286 transcriptional activator, Rgg/GadR/MutR family, C-terminal domain; Region: RGG_Cterm; TIGR01716 1155071000287 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 1155071000288 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 1155071000289 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 1155071000290 putative active site [active] 1155071000291 Fructose-1-phosphate kinase and related fructose-6-phosphate kinase (PfkB) [Carbohydrate transport and metabolism]; Region: FruK; COG1105 1155071000292 1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164 1155071000293 putative substrate binding site [chemical binding]; other site 1155071000294 putative ATP binding site [chemical binding]; other site 1155071000295 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569 1155071000296 active site 1155071000297 P-loop; other site 1155071000298 phosphorylation site [posttranslational modification] 1155071000299 Phosphotransferase system, fructose-specific IIC component [Carbohydrate transport and metabolism]; Region: FruA; COG1299 1155071000300 Phosphotransferase system, EIIC; Region: PTS_EIIC; pfam02378 1155071000301 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 1155071000302 active site 1155071000303 phosphorylation site [posttranslational modification] 1155071000304 tagatose 1,6-diphosphate aldolase; Reviewed; Region: PRK04161 1155071000305 S-formylglutathione hydrolase; Region: PLN02442 1155071000306 S-formylglutathione hydrolase; Region: fghA_ester_D; TIGR02821 1155071000307 class III alcohol dehydrogenases; Region: alcohol_DH_class_III; cd08300 1155071000308 S-(hydroxymethyl)glutathione dehydrogenase/class III alcohol dehydrogenase; Region: adh_III_F_hyde; TIGR02818 1155071000309 substrate binding site [chemical binding]; other site 1155071000310 catalytic Zn binding site [ion binding]; other site 1155071000311 NAD binding site [chemical binding]; other site 1155071000312 structural Zn binding site [ion binding]; other site 1155071000313 dimer interface [polypeptide binding]; other site 1155071000314 50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359 1155071000315 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 1155071000316 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Bacillus subtilis yoeA; Region: MATE_yoeA_like; cd13138 1155071000317 DNA polymerase III PolC; Validated; Region: polC; PRK00448 1155071000318 DNA polymerase III polC-type N-terminus; Region: DNA_pol3_alph_N; pfam11490 1155071000319 polC_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold nucleic acid binding domain of Bacillus subtilis type C replicative DNA polymerase III alpha subunit (polC). Replication in B. subtilis and Staphylococcus aureus requires two...; Region: polC_OBF; cd04484 1155071000320 generic binding surface II; other site 1155071000321 generic binding surface I; other site 1155071000322 Polymerase and Histidinol Phosphatase domain; Region: PHP; cl17102 1155071000323 active site 1155071000324 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 1155071000325 active site 1155071000326 catalytic site [active] 1155071000327 substrate binding site [chemical binding]; other site 1155071000328 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III at PolC gene; Region: PHP_PolIIIA_POLC; cd07435 1155071000329 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1155071000330 MarR family; Region: MarR; pfam01047 1155071000331 Predicted flavoprotein [General function prediction only]; Region: COG0431 1155071000332 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 1155071000333 pyruvate dehydrogenase E1 component, alpha subunit; Region: PDH_E1_alph_y; TIGR03182 1155071000334 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 1155071000335 tetramer interface [polypeptide binding]; other site 1155071000336 TPP-binding site [chemical binding]; other site 1155071000337 heterodimer interface [polypeptide binding]; other site 1155071000338 phosphorylation loop region [posttranslational modification] 1155071000339 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 1155071000340 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 1155071000341 alpha subunit interface [polypeptide binding]; other site 1155071000342 TPP binding site [chemical binding]; other site 1155071000343 heterodimer interface [polypeptide binding]; other site 1155071000344 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 1155071000345 branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856 1155071000346 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 1155071000347 E3 interaction surface; other site 1155071000348 lipoyl attachment site [posttranslational modification]; other site 1155071000349 e3 binding domain; Region: E3_binding; pfam02817 1155071000350 e3 binding domain; Region: E3_binding; pfam02817 1155071000351 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 1155071000352 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 1155071000353 E3 interaction surface; other site 1155071000354 lipoyl attachment site [posttranslational modification]; other site 1155071000355 dihydrolipoamide dehydrogenase; Region: lipoamide_DH; TIGR01350 1155071000356 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1155071000357 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 1155071000358 Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095 1155071000359 lipoyltransferase and lipoate-protein ligase; Region: lipoyltrans; TIGR00545 1155071000360 Bacterial lipoate protein ligase C-terminus; Region: Lip_prot_lig_C; pfam10437 1155071000361 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 1155071000362 M20 Peptidase Aminoacyclase-1 YxeP-like proteins, including YxeP, YtnL, YjiB and HipO2; Region: M20_Acy1_YxeP_like; cd05669 1155071000363 metal binding site [ion binding]; metal-binding site 1155071000364 dimer interface [polypeptide binding]; other site 1155071000365 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1155071000366 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1155071000367 putative substrate translocation pore; other site 1155071000368 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1155071000369 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1155071000370 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1155071000371 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1155071000372 The substrate binding domain of LysR-type transcriptional regulator MleR which required for malolactic fermentation, contains type 2 periplasmic binidning fold; Region: PBP2_MleR; cd08437 1155071000373 putative dimerization interface [polypeptide binding]; other site 1155071000374 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1155071000375 non-specific DNA binding site [nucleotide binding]; other site 1155071000376 salt bridge; other site 1155071000377 sequence-specific DNA binding site [nucleotide binding]; other site 1155071000378 malate dehydrogenase; Provisional; Region: PRK13529 1155071000379 Malic enzyme, N-terminal domain; Region: malic; pfam00390 1155071000380 NAD(P) binding domain of malic enzyme (ME), subgroup 1; Region: NAD_bind_1_malic_enz; cd05312 1155071000381 NAD(P) binding site [chemical binding]; other site 1155071000382 Membrane transport protein; Region: Mem_trans; cl09117 1155071000383 bicupin, oxalate decarboxylase family; Region: bicupin_oxalic; TIGR03404 1155071000384 Cupin; Region: Cupin_1; smart00835 1155071000385 Cupin; Region: Cupin_1; smart00835 1155071000386 Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes [Energy production and conversion]; Region: Lpd; COG1249 1155071000387 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1155071000388 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 1155071000389 Protein of unknown function (DUF1275); Region: DUF1275; pfam06912 1155071000390 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 1155071000391 active site 1155071000392 catalytic residues [active] 1155071000393 metal binding site [ion binding]; metal-binding site 1155071000394 DNA-binding transcriptional activator YeiL; Provisional; Region: PRK10402 1155071000395 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 1155071000396 ligand binding site [chemical binding]; other site 1155071000397 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cl17320 1155071000398 bifunctional acetaldehyde-CoA/alcohol dehydrogenase; Provisional; Region: PRK13805 1155071000399 Coenzyme A acylating aldehyde dehydrogenase (ACDH), ALDH family 20-like; Region: ALDH_F20_ACDH; cd07122 1155071000400 putative catalytic cysteine [active] 1155071000401 C-terminal alcohol dehydrogenase domain of the acetaldehyde dehydrogenase-alcohol dehydrogenase bifunctional two-domain protein (AAD); Region: AAD_C; cd08178 1155071000402 putative active site [active] 1155071000403 metal binding site [ion binding]; metal-binding site 1155071000404 Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353 1155071000405 16S/18S rRNA binding site [nucleotide binding]; other site 1155071000406 S13e-L30e interaction site [polypeptide binding]; other site 1155071000407 25S rRNA binding site [nucleotide binding]; other site 1155071000408 polynucleotide phosphorylase/polyadenylase; Provisional; Region: PRK11824 1155071000409 Polyribonucleotide nucleotidyltransferase, repeat 1; Region: RNase_PH_PNPase_1; cd11363 1155071000410 RNase E interface [polypeptide binding]; other site 1155071000411 trimer interface [polypeptide binding]; other site 1155071000412 Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364 1155071000413 RNase E interface [polypeptide binding]; other site 1155071000414 trimer interface [polypeptide binding]; other site 1155071000415 active site 1155071000416 Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393 1155071000417 S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472 1155071000418 RNA binding site [nucleotide binding]; other site 1155071000419 Serine acetyltransferase [Amino acid transport and metabolism]; Region: CysE; COG1045 1155071000420 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354 1155071000421 trimer interface [polypeptide binding]; other site 1155071000422 active site 1155071000423 substrate binding site [chemical binding]; other site 1155071000424 cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260 1155071000425 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 1155071000426 active site 1155071000427 HIGH motif; other site 1155071000428 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 1155071000429 KMSKS motif; other site 1155071000430 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 1155071000431 tRNA binding surface [nucleotide binding]; other site 1155071000432 anticodon binding site; other site 1155071000433 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 1155071000434 active site 1155071000435 metal binding site [ion binding]; metal-binding site 1155071000436 dimerization interface [polypeptide binding]; other site 1155071000437 Predicted Zn-dependent protease (DUF2268); Region: DUF2268; pfam10026 1155071000438 Helix-Turn-Helix DNA binding domain of the transcription regulators TipAL, Mta, and SkgA; Region: HTH_TipAL-Mta; cd01106 1155071000439 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 1155071000440 DNA binding residues [nucleotide binding] 1155071000441 dimer interface [polypeptide binding]; other site 1155071000442 TipAS antibiotic-recognition domain; Region: TipAS; pfam07739 1155071000443 A predicted NlpC/p60-like peptidase; Region: BtrH; pfam14399 1155071000444 Predicted transcriptional regulators [Transcription]; Region: COG1695 1155071000445 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 1155071000446 rRNA methylase, putative, group 3; Region: rRNA_methyl_3; TIGR00186 1155071000447 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032 1155071000448 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 1155071000449 EDD domain protein, DegV family; Region: DegV; TIGR00762 1155071000450 Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645 1155071000451 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1155071000452 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1155071000453 non-specific DNA binding site [nucleotide binding]; other site 1155071000454 salt bridge; other site 1155071000455 sequence-specific DNA binding site [nucleotide binding]; other site 1155071000456 L13_leader; Ribosomal protein L13 leader 1155071000457 Ribosomal protein L13. Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392 1155071000458 23S rRNA interface [nucleotide binding]; other site 1155071000459 L3 interface [polypeptide binding]; other site 1155071000460 30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132 1155071000461 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 1155071000462 DNA binding site [nucleotide binding] 1155071000463 active site 1155071000464 Int/Topo IB signature motif; other site 1155071000465 catalytic residues [active] 1155071000466 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1155071000467 dimerization interface [polypeptide binding]; other site 1155071000468 putative DNA binding site [nucleotide binding]; other site 1155071000469 putative Zn2+ binding site [ion binding]; other site 1155071000470 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 1155071000471 active site residue [active] 1155071000472 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 1155071000473 catalytic residues [active] 1155071000474 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 1155071000475 thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292 1155071000476 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1155071000477 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1155071000478 30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08061 1155071000479 Predicted dithiol-disulfide isomerase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FrnE; COG2761 1155071000480 DsbA family, FrnE subfamily; FrnE is a DsbA-like protein containing a CXXC motif. It is presumed to be a thiol oxidoreductase involved in polyketide biosynthesis, specifically in the production of the aromatic antibiotics frenolicin and nanaomycins; Region: DsbA_FrnE; cd03024 1155071000481 catalytic residues [active] 1155071000482 Protein of unknown function (DUF1211); Region: DUF1211; cl01421 1155071000483 Antidote-toxin recognition MazE; Region: Antitoxin-MazE; cl00877 1155071000484 PemK-like protein; Region: PemK; pfam02452 1155071000485 PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal)...; Region: PDZ_signaling; cd00992 1155071000486 protein binding site [polypeptide binding]; other site 1155071000487 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 1155071000488 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 1155071000489 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1155071000490 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1155071000491 active site 1155071000492 phosphorylation site [posttranslational modification] 1155071000493 intermolecular recognition site; other site 1155071000494 dimerization interface [polypeptide binding]; other site 1155071000495 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1155071000496 DNA binding residues [nucleotide binding] 1155071000497 dimerization interface [polypeptide binding]; other site 1155071000498 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 1155071000499 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 1155071000500 acyl-activating enzyme (AAE) consensus motif; other site 1155071000501 AMP binding site [chemical binding]; other site 1155071000502 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1155071000503 peptide synthase; Provisional; Region: PRK12316 1155071000504 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 1155071000505 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 1155071000506 acyl-activating enzyme (AAE) consensus motif; other site 1155071000507 AMP binding site [chemical binding]; other site 1155071000508 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1155071000509 non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261 1155071000510 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 1155071000511 acyl-activating enzyme (AAE) consensus motif; other site 1155071000512 AMP binding site [chemical binding]; other site 1155071000513 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1155071000514 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 1155071000515 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 1155071000516 acyl-activating enzyme (AAE) consensus motif; other site 1155071000517 AMP binding site [chemical binding]; other site 1155071000518 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1155071000519 non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261 1155071000520 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 1155071000521 acyl-activating enzyme (AAE) consensus motif; other site 1155071000522 AMP binding site [chemical binding]; other site 1155071000523 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 1155071000524 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 1155071000525 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 1155071000526 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 1155071000527 active site 1155071000528 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 1155071000529 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1155071000530 KR domain; Region: KR; pfam08659 1155071000531 NAD(P) binding site [chemical binding]; other site 1155071000532 active site 1155071000533 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1155071000534 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 1155071000535 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 1155071000536 active site 1155071000537 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 1155071000538 ketoreductase (KR), subgroup 2, complex (x) SDRs; Region: KR_2_SDR_x; cd08953 1155071000539 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 1155071000540 putative NADP binding site [chemical binding]; other site 1155071000541 active site 1155071000542 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1155071000543 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 1155071000544 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cd00267 1155071000545 Walker A/P-loop; other site 1155071000546 ATP binding site [chemical binding]; other site 1155071000547 Q-loop/lid; other site 1155071000548 ABC transporter signature motif; other site 1155071000549 Walker B; other site 1155071000550 D-loop; other site 1155071000551 H-loop/switch region; other site 1155071000552 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 1155071000553 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 1155071000554 active site 1155071000555 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1155071000556 Condensation domain; Region: Condensation; pfam00668 1155071000557 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 1155071000558 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 1155071000559 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 1155071000560 acyl-activating enzyme (AAE) consensus motif; other site 1155071000561 AMP binding site [chemical binding]; other site 1155071000562 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1155071000563 Condensation domain; Region: Condensation; pfam00668 1155071000564 non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261 1155071000565 Predicted thioesterase involved in non-ribosomal peptide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: GrsT; COG3208 1155071000566 4'-phosphopantetheinyl transferase superfamily; Region: ACPS; pfam01648 1155071000567 Pseudomonas avirulence D protein (AvrD); Region: AvrD; pfam05655 1155071000568 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 1155071000569 Transposase; Region: DDE_Tnp_ISL3; pfam01610 1155071000570 HTH-like domain; Region: HTH_21; pfam13276 1155071000571 Integrase core domain; Region: rve; pfam00665 1155071000572 Integrase core domain; Region: rve_2; pfam13333 1155071000573 Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; cl17295 1155071000574 Alpha/beta hydrolase of unknown function (DUF915); Region: DUF915; pfam06028 1155071000575 PGAP1-like protein; Region: PGAP1; pfam07819 1155071000576 Predicted flavoprotein [General function prediction only]; Region: COG0431 1155071000577 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 1155071000578 Predicted flavoprotein [General function prediction only]; Region: COG0431 1155071000579 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 1155071000580 FMN-binding domain; Region: FMN_bind; cl01081 1155071000581 flavocytochrome c; Region: flavo_cyto_c; TIGR01813 1155071000582 L-aspartate oxidase; Provisional; Region: PRK06175 1155071000583 Mevalonate kinase [Lipid metabolism]; Region: ERG12; COG1577 1155071000584 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 1155071000585 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 1155071000586 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 1155071000587 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 1155071000588 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1155071000589 ABC-ATPase subunit interface; other site 1155071000590 dimer interface [polypeptide binding]; other site 1155071000591 putative PBP binding regions; other site 1155071000592 Metal binding protein PsaA. These proteins have been shown to function as initial receptors in ABC transport of Mn2+ and as surface adhesins in some eubacterial species. They belong to the TroA superfamily of periplasmic metal binding proteins that...; Region: PsaA; cd01137 1155071000593 ABC-type metal ion transport system, periplasmic component/surface adhesin [Inorganic ion transport and metabolism]; Region: LraI; COG0803 1155071000594 metal binding site [ion binding]; metal-binding site 1155071000595 Iron dependent repressor, N-terminal DNA binding domain; Region: Fe_dep_repress; pfam01325 1155071000596 Helix-turn-helix diphteria tox regulatory element; Region: HTH_DTXR; smart00529 1155071000597 Iron dependent repressor, metal binding and dimerisation domain; Region: Fe_dep_repr_C; pfam02742 1155071000598 FeoA domain; Region: FeoA; pfam04023 1155071000599 putative TIM-barrel protein, nifR3 family; Region: nifR3_yhdG; TIGR00737 1155071000600 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 1155071000601 FMN binding site [chemical binding]; other site 1155071000602 active site 1155071000603 catalytic residues [active] 1155071000604 substrate binding site [chemical binding]; other site 1155071000605 Hsp33-like chaperonin; Reviewed; Region: hslO; PRK00114 1155071000606 Heat shock protein 33 (Hsp33): Cytosolic protein that acts as a molecular chaperone under oxidative conditions. In normal (reducing) cytosolic conditions, four conserved Cys residues are coordinated by a Zn ion. Under oxidative stress (such as heat...; Region: Hsp33; cd00498 1155071000607 dimerization interface [polypeptide binding]; other site 1155071000608 domain crossover interface; other site 1155071000609 redox-dependent activation switch; other site 1155071000610 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 1155071000611 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: ipk; PRK00128 1155071000612 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 1155071000613 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 1155071000614 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1155071000615 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1155071000616 putative Zn2+ binding site [ion binding]; other site 1155071000617 putative DNA binding site [nucleotide binding]; other site 1155071000618 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 1155071000619 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 1155071000620 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 1155071000621 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1155071000622 ABC-ATPase subunit interface; other site 1155071000623 dimer interface [polypeptide binding]; other site 1155071000624 putative PBP binding regions; other site 1155071000625 tyrosyl-tRNA synthetase; Validated; Region: PRK05912 1155071000626 catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805 1155071000627 active site 1155071000628 HIGH motif; other site 1155071000629 dimer interface [polypeptide binding]; other site 1155071000630 KMSKS motif; other site 1155071000631 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1155071000632 RNA binding surface [nucleotide binding]; other site 1155071000633 Membrane carboxypeptidase (penicillin-binding protein) [Cell envelope biogenesis, outer membrane]; Region: MrcB; COG0744 1155071000634 Transglycosylase; Region: Transgly; pfam00912 1155071000635 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 1155071000636 Lacto-rpoB; Lacto-rpoB RNA motif 1155071000637 DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405 1155071000638 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585 1155071000639 RNA polymerase Rpb2, domain 2; Region: RNA_pol_Rpb2_2; pfam04561 1155071000640 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585 1155071000641 RNA polymerase beta subunit external 1 domain; Region: RNA_pol_Rpb2_45; pfam10385 1155071000642 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 1155071000643 RPB1 interaction site [polypeptide binding]; other site 1155071000644 RPB10 interaction site [polypeptide binding]; other site 1155071000645 RPB11 interaction site [polypeptide binding]; other site 1155071000646 RPB3 interaction site [polypeptide binding]; other site 1155071000647 RPB12 interaction site [polypeptide binding]; other site 1155071000648 DNA-directed RNA polymerase subunit beta'; Provisional; Region: PRK00566 1155071000649 RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997 1155071000650 RNA polymerase I subunit A N-terminus; Region: RPOLA_N; smart00663 1155071000651 RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983 1155071000652 RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000 1155071000653 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 1155071000654 Rpb1 (beta') - Rpb6 (omega) interaction site [polypeptide binding]; other site 1155071000655 G-loop; other site 1155071000656 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 1155071000657 DNA binding site [nucleotide binding] 1155071000658 Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site 1155071000659 Protein of unknown function (DUF1033); Region: DUF1033; pfam06279 1155071000660 Type II/IV secretion system protein; Region: T2SE; pfam00437 1155071000661 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 1155071000662 Walker A motif; other site 1155071000663 ATP binding site [chemical binding]; other site 1155071000664 Walker B motif; other site 1155071000665 Type II secretory pathway, component PulF [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulF; COG1459 1155071000666 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 1155071000667 Competence protein ComGC [Intracellular trafficking and secretion]; Region: ComGC; COG4537 1155071000668 Type II secretory pathway, pseudopilin PulG [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulG; COG2165 1155071000669 Type II secretory pathway, pseudopilin PulG [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulG; COG2165 1155071000670 Type II secretory pathway pseudopilin; Region: PulG; pfam11773 1155071000671 Competence protein ComGF [Intracellular trafficking and secretion]; Region: ComGF; COG4940 1155071000672 Adenine-specific DNA methylase [DNA replication, recombination, and repair]; Region: COG0827 1155071000673 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1155071000674 S-adenosylmethionine binding site [chemical binding]; other site 1155071000675 acetate kinase A/propionate kinase 2; Reviewed; Region: PRK00180 1155071000676 propionate/acetate kinase; Provisional; Region: PRK12379 1155071000677 Transposase IS200 like; Region: Y1_Tnp; pfam01797 1155071000678 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1155071000679 non-specific DNA binding site [nucleotide binding]; other site 1155071000680 salt bridge; other site 1155071000681 sequence-specific DNA binding site [nucleotide binding]; other site 1155071000682 CAAX protease self-immunity; Region: Abi; pfam02517 1155071000683 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232 1155071000684 pyrroline-5-carboxylate reductase; Reviewed; Region: PRK11880 1155071000685 Cellulase M and related proteins [Carbohydrate transport and metabolism]; Region: FrvX; COG1363 1155071000686 glutamyl aminopeptidase; Region: glu_aminopep; TIGR03107 1155071000687 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 1155071000688 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 1155071000689 catalytic residues [active] 1155071000690 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 1155071000691 putative tRNA-binding site [nucleotide binding]; other site 1155071000692 MarR family; Region: MarR_2; cl17246 1155071000693 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1155071000694 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 1155071000695 active site residue [active] 1155071000696 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 1155071000697 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 1155071000698 dimer interface [polypeptide binding]; other site 1155071000699 ssDNA binding site [nucleotide binding]; other site 1155071000700 tetramer (dimer of dimers) interface [polypeptide binding]; other site 1155071000701 Periplasmic sugar-binding domain of active transport systems that are members of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_sugar_binding_like; cd01536 1155071000702 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 1155071000703 ligand binding site [chemical binding]; other site 1155071000704 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 1155071000705 Histidine kinase; Region: HisKA_3; pfam07730 1155071000706 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 1155071000707 ATP binding site [chemical binding]; other site 1155071000708 Mg2+ binding site [ion binding]; other site 1155071000709 G-X-G motif; other site 1155071000710 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1155071000711 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1155071000712 active site 1155071000713 phosphorylation site [posttranslational modification] 1155071000714 intermolecular recognition site; other site 1155071000715 dimerization interface [polypeptide binding]; other site 1155071000716 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1155071000717 DNA binding residues [nucleotide binding] 1155071000718 dimerization interface [polypeptide binding]; other site 1155071000719 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 1155071000720 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 1155071000721 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cl00025 1155071000722 active pocket/dimerization site; other site 1155071000723 active site 1155071000724 phosphorylation site [posttranslational modification] 1155071000725 PTS system sorbose subfamily IIB component; Region: PTSIIB_sorb; pfam03830 1155071000726 active site 1155071000727 phosphorylation site [posttranslational modification] 1155071000728 Phosphotransferase system, mannose/fructose/N-acetylgalactosamine-specific component IIC [Carbohydrate transport and metabolism]; Region: ManY; COG3715 1155071000729 PTS system mannose/fructose/sorbose family IID component; Region: EIID-AGA; pfam03613 1155071000730 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 1155071000731 oligomerisation interface [polypeptide binding]; other site 1155071000732 mobile loop; other site 1155071000733 roof hairpin; other site 1155071000734 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 1155071000735 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 1155071000736 ring oligomerisation interface [polypeptide binding]; other site 1155071000737 ATP/Mg binding site [chemical binding]; other site 1155071000738 stacking interactions; other site 1155071000739 hinge regions; other site 1155071000740 Predicted membrane protein [Function unknown]; Region: COG4640 1155071000741 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 1155071000742 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 1155071000743 active site 1155071000744 Membrane carboxypeptidase (penicillin-binding protein) [Cell envelope biogenesis, outer membrane]; Region: MrcB; COG0744 1155071000745 Transglycosylase; Region: Transgly; pfam00912 1155071000746 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 1155071000747 50S ribosomal protein L33; Validated; Region: rpmG; PRK00504 1155071000748 Preprotein translocase subunit SecE [Intracellular trafficking and secretion]; Region: SecE; COG0690 1155071000749 transcription antitermination protein NusG; Validated; Region: nusG; PRK05609 1155071000750 Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891 1155071000751 putative homodimer interface [polypeptide binding]; other site 1155071000752 NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091 1155071000753 heterodimer interface [polypeptide binding]; other site 1155071000754 homodimer interface [polypeptide binding]; other site 1155071000755 Polyphosphate(polyP) polymerase domain of yeast vacuolar transport chaperone (VTC) proteins VTC-2, -3 and- 4, and similar proteins; Region: PolyPPase_VTC_like; cd07750 1155071000756 putative metal binding residues [ion binding]; other site 1155071000757 signature motif; other site 1155071000758 dimer interface [polypeptide binding]; other site 1155071000759 active site 1155071000760 polyP binding site; other site 1155071000761 substrate binding site [chemical binding]; other site 1155071000762 acceptor-phosphate pocket; other site 1155071000763 leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390 1155071000764 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 1155071000765 HIGH motif; other site 1155071000766 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 1155071000767 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 1155071000768 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 1155071000769 active site 1155071000770 KMSKS motif; other site 1155071000771 Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958 1155071000772 tRNA binding surface [nucleotide binding]; other site 1155071000773 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 1155071000774 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1155071000775 substrate binding pocket [chemical binding]; other site 1155071000776 membrane-bound complex binding site; other site 1155071000777 hinge residues; other site 1155071000778 ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464 1155071000779 NLPA lipoprotein; Region: Lipoprotein_9; pfam03180 1155071000780 hypothetical protein; Provisional; Region: PRK06446 1155071000781 Uncharacterized M20 Dipeptidases; Region: M20_dipept_like_4; cd05681 1155071000782 metal binding site [ion binding]; metal-binding site 1155071000783 dimer interface [polypeptide binding]; other site 1155071000784 ABC-type metal ion transport system, ATPase component [Inorganic ion transport and metabolism]; Region: AbcC; COG1135 1155071000785 ATP-binding cassette domain of methionine transporter; Region: ABC_MetN_methionine_transporter; cd03258 1155071000786 Walker A/P-loop; other site 1155071000787 ATP binding site [chemical binding]; other site 1155071000788 Q-loop/lid; other site 1155071000789 ABC transporter signature motif; other site 1155071000790 Walker B; other site 1155071000791 D-loop; other site 1155071000792 H-loop/switch region; other site 1155071000793 NIL domain; Region: NIL; pfam09383 1155071000794 ABC-type metal ion transport system, permease component [Inorganic ion transport and metabolism]; Region: AbcD; COG2011 1155071000795 dimer interface [polypeptide binding]; other site 1155071000796 conserved gate region; other site 1155071000797 ABC-ATPase subunit interface; other site 1155071000798 Predicted amidohydrolase [General function prediction only]; Region: COG0388 1155071000799 Uncharacterized subgroup of the nitrilase superfamily (putative class 13 nitrilases); Region: nitrilase_5; cd07583 1155071000800 putative active site [active] 1155071000801 catalytic triad [active] 1155071000802 putative dimer interface [polypeptide binding]; other site 1155071000803 Uncharacterized conserved protein [Function unknown]; Region: COG1912 1155071000804 hypothetical protein; Provisional; Region: PRK13661 1155071000805 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 1155071000806 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 1155071000807 Walker A/P-loop; other site 1155071000808 ATP binding site [chemical binding]; other site 1155071000809 Q-loop/lid; other site 1155071000810 ABC transporter signature motif; other site 1155071000811 Walker B; other site 1155071000812 D-loop; other site 1155071000813 H-loop/switch region; other site 1155071000814 ATP-binding cassette cobalt transporter; Region: DUF3744; pfam12558 1155071000815 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 1155071000816 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 1155071000817 Walker A/P-loop; other site 1155071000818 ATP binding site [chemical binding]; other site 1155071000819 Q-loop/lid; other site 1155071000820 ABC transporter signature motif; other site 1155071000821 Walker B; other site 1155071000822 D-loop; other site 1155071000823 H-loop/switch region; other site 1155071000824 ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619 1155071000825 Predicted S-adenosylmethionine-dependent methyltransferase involved in bacterial cell division [Cell envelope biogenesis, outer membrane]; Region: GidB; COG0357 1155071000826 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1155071000827 S-adenosylmethionine binding site [chemical binding]; other site 1155071000828 Uncharacterized conserved protein [Function unknown]; Region: LemA; COG1704 1155071000829 heat shock protein HtpX; Provisional; Region: PRK04897 1155071000830 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 1155071000831 FtsX-like permease family; Region: FtsX; pfam02687 1155071000832 ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]; Region: LolE; COG4591 1155071000833 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 1155071000834 FtsX-like permease family; Region: FtsX; pfam02687 1155071000835 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 1155071000836 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 1155071000837 Walker A/P-loop; other site 1155071000838 ATP binding site [chemical binding]; other site 1155071000839 Q-loop/lid; other site 1155071000840 ABC transporter signature motif; other site 1155071000841 Walker B; other site 1155071000842 D-loop; other site 1155071000843 H-loop/switch region; other site 1155071000844 probable dihydroxyacetone kinase regulator; Region: DHAK_reg; TIGR02366 1155071000845 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1155071000846 Transcriptional regulator C-terminal region; Region: TetR_C_8; pfam14278 1155071000847 Predicted metal-binding, possibly nucleic acid-binding protein [General function prediction only]; Region: COG1399 1155071000848 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1155071000849 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1155071000850 active site 1155071000851 phosphorylation site [posttranslational modification] 1155071000852 intermolecular recognition site; other site 1155071000853 dimerization interface [polypeptide binding]; other site 1155071000854 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1155071000855 DNA binding site [nucleotide binding] 1155071000856 transcriptional regulator NrdR; Validated; Region: nrdR; PRK00464 1155071000857 ATP cone domain; Region: ATP-cone; pfam03477 1155071000858 Replication initiation/membrane attachment protein [DNA replication, recombination, and repair]; Region: DnaB; COG3611 1155071000859 primosomal protein DnaI; Reviewed; Region: PRK08939 1155071000860 Primosomal protein DnaI N-terminus; Region: DnaI_N; pfam07319 1155071000861 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1155071000862 Walker A motif; other site 1155071000863 ATP binding site [chemical binding]; other site 1155071000864 Walker B motif; other site 1155071000865 GTP-binding protein Der; Reviewed; Region: PRK00093 1155071000866 EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894 1155071000867 G1 box; other site 1155071000868 GTP/Mg2+ binding site [chemical binding]; other site 1155071000869 Switch I region; other site 1155071000870 G2 box; other site 1155071000871 Switch II region; other site 1155071000872 G3 box; other site 1155071000873 G4 box; other site 1155071000874 G5 box; other site 1155071000875 EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895 1155071000876 G1 box; other site 1155071000877 GTP/Mg2+ binding site [chemical binding]; other site 1155071000878 Switch I region; other site 1155071000879 G2 box; other site 1155071000880 G3 box; other site 1155071000881 Switch II region; other site 1155071000882 G4 box; other site 1155071000883 G5 box; other site 1155071000884 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 1155071000885 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 1155071000886 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 1155071000887 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1155071000888 active site 1155071000889 phosphorylation site [posttranslational modification] 1155071000890 intermolecular recognition site; other site 1155071000891 dimerization interface [polypeptide binding]; other site 1155071000892 LytTr DNA-binding domain; Region: LytTR; pfam04397 1155071000893 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 1155071000894 COMC family; Region: ComC; pfam03047 1155071000895 Bacteriocin class II with double-glycine leader peptide; Region: Bacteriocin_IIc; pfam10439 1155071000896 COMC family; Region: ComC; pfam03047 1155071000897 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 1155071000898 catalytic residues [active] 1155071000899 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 1155071000900 nucleotide binding site [chemical binding]; other site 1155071000901 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 1155071000902 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 1155071000903 seryl-tRNA synthetase; Provisional; Region: PRK05431 1155071000904 Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403 1155071000905 Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770 1155071000906 dimer interface [polypeptide binding]; other site 1155071000907 active site 1155071000908 motif 1; other site 1155071000909 motif 2; other site 1155071000910 motif 3; other site 1155071000911 T-box; T-box leader 1155071000912 Predicted O-acyltransferase [General function prediction only]; Region: COG3274 1155071000913 Acyltransferase family; Region: Acyl_transf_3; pfam01757 1155071000914 Domain of unknown function (DUF956); Region: DUF956; pfam06115 1155071000915 Phosphotransferase system, mannose/fructose/N-acetylgalactosamine-specific component IID [Carbohydrate transport and metabolism]; Region: ManZ; COG3716 1155071000916 PTS system mannose-specific transporter subunit IIC; Provisional; Region: PRK15065 1155071000917 PTS system mannose-specific transporter subunits IIAB; Provisional; Region: PRK15088 1155071000918 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006 1155071000919 active pocket/dimerization site; other site 1155071000920 active site 1155071000921 phosphorylation site [posttranslational modification] 1155071000922 PTS_IIB, PTS system, Mannose/sorbose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_man; cd00001 1155071000923 active site 1155071000924 phosphorylation site [posttranslational modification] 1155071000925 helicase, putative, RecD/TraA family; Region: recD_rel; TIGR01448 1155071000926 H3TH domains of structure-specific 5' nucleases (or flap endonuclease-1-like) involved in DNA replication, repair, and recombination; Region: H3TH_StructSpec-5'-nucleases; cl14815 1155071000927 DNA binding site [nucleotide binding] 1155071000928 AAA domain; Region: AAA_30; pfam13604 1155071000929 Family description; Region: UvrD_C_2; pfam13538 1155071000930 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 1155071000931 The S24, S26 LexA/signal peptidase superfamily contains LexA-related and type I signal peptidase families. The S24 LexA protein domains include: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC 3.4.21.88), the...; Region: Peptidase_S24_S26; cd06462 1155071000932 Catalytic site [active] 1155071000933 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 1155071000934 ribonuclease HIII; Provisional; Region: PRK00996 1155071000935 Domain of unknown function (DUF3378); Region: DUF3378; pfam11858 1155071000936 bacterial Ribonuclease HIII-like; Region: RNase_HII_bacteria_HIII_like; cd06590 1155071000937 RNA/DNA hybrid binding site [nucleotide binding]; other site 1155071000938 active site 1155071000939 Uncharacterized membrane protein, required for colicin V production [General function prediction only]; Region: CvpA; COG1286 1155071000940 Colicin V production protein; Region: Colicin_V; pfam02674 1155071000941 recombination and DNA strand exchange inhibitor protein; Reviewed; Region: PRK00409 1155071000942 MutS domain III; Region: MutS_III; pfam05192 1155071000943 ATP-binding cassette domain of MutS2; Region: ABC_MutS2; cd03280 1155071000944 Walker A/P-loop; other site 1155071000945 ATP binding site [chemical binding]; other site 1155071000946 Q-loop/lid; other site 1155071000947 ABC transporter signature motif; other site 1155071000948 Walker B; other site 1155071000949 D-loop; other site 1155071000950 H-loop/switch region; other site 1155071000951 Smr domain; Region: Smr; pfam01713 1155071000952 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 1155071000953 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 1155071000954 catalytic residues [active] 1155071000955 formaldehyde dehydrogenase (FDH)-like; Region: FDH_like_ADH3; cd08287 1155071000956 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 1155071000957 catalytic Zn binding site [ion binding]; other site 1155071000958 NAD(P) binding site [chemical binding]; other site 1155071000959 structural Zn binding site [ion binding]; other site 1155071000960 A/G-specific DNA glycosylase [DNA replication, recombination, and repair]; Region: MutY; COG1194 1155071000961 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 1155071000962 minor groove reading motif; other site 1155071000963 helix-hairpin-helix signature motif; other site 1155071000964 substrate binding pocket [chemical binding]; other site 1155071000965 active site 1155071000966 DNA glycosylase (MutY in bacteria and hMYH in humans) is responsible for repairing misread A*oxoG residues to C*G by removing the inappropriately paired adenine base from the DNA backbone. It belongs to the Nudix hydrolase superfamily and is important...; Region: DNA_Glycosylase_C; cd03431 1155071000967 DNA binding and oxoG recognition site [nucleotide binding] 1155071000968 30S ribosomal protein S6; Reviewed; Region: rpsF; PRK00453 1155071000969 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 1155071000970 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 1155071000971 dimer interface [polypeptide binding]; other site 1155071000972 ssDNA binding site [nucleotide binding]; other site 1155071000973 tetramer (dimer of dimers) interface [polypeptide binding]; other site 1155071000974 30S ribosomal protein S18; Reviewed; Region: rpsR; PRK00391 1155071000975 Transposase; Region: DEDD_Tnp_IS110; pfam01548 1155071000976 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 1155071000977 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 1155071000978 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 1155071000979 TraX protein; Region: TraX; cl05434 1155071000980 LytTr DNA-binding domain; Region: LytTR; pfam04397 1155071000981 Protein of unknown function (DUF1129); Region: DUF1129; pfam06570 1155071000982 Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598 1155071000983 uncharacterized bacterial subfamily of the Escherichia coli CorA-Salmonella typhimurium ZntB family; Region: EcCorA_ZntB-like_u2; cd12827 1155071000984 Cl binding site [ion binding]; other site 1155071000985 oligomer interface [polypeptide binding]; other site 1155071000986 excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349 1155071000987 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 1155071000988 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 1155071000989 ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271 1155071000990 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 1155071000991 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 1155071000992 Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092 1155071000993 active site 1155071000994 Deoxycytidylate deaminase domain. Deoxycytidylate deaminase catalyzes the deamination of dCMP to dUMP, providing the nucleotide substrate for thymidylate synthase. The enzyme binds Zn++, which is required for catalytic activity. The activity of the...; Region: deoxycytidylate_deaminase; cd01286 1155071000995 catalytic motif [active] 1155071000996 Zn binding site [ion binding]; other site 1155071000997 Ion transport protein; Region: Ion_trans; pfam00520 1155071000998 Ion channel; Region: Ion_trans_2; pfam07885 1155071000999 elongation factor P; Validated; Region: PRK00529 1155071001000 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 1155071001001 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 1155071001002 RNA binding site [nucleotide binding]; other site 1155071001003 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 1155071001004 RNA binding site [nucleotide binding]; other site 1155071001005 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1302 1155071001006 transcription antitermination protein NusB; Reviewed; Region: nusB; PRK00202 1155071001007 putative RNA binding site [nucleotide binding]; other site 1155071001008 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1155071001009 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1155071001010 DNA binding site [nucleotide binding] 1155071001011 domain linker motif; other site 1155071001012 Ligand binding domain of the lacI-like transcription regulator from a novel metal-reducing bacterium Alkaliphilus Metalliredigens (strain Qymf) and its close homologs; Region: PBP1_Qymf_like; cd06291 1155071001013 dimerization interface [polypeptide binding]; other site 1155071001014 ligand binding site [chemical binding]; other site 1155071001015 sodium binding site [ion binding]; other site 1155071001016 sucrose-6-phosphate hydrolase; Region: scrB_fam; TIGR01322 1155071001017 Glycosyl hydrolase family 32, beta-fructosidases; Region: GH32_B_Fructosidase; cd08996 1155071001018 substrate binding [chemical binding]; other site 1155071001019 active site 1155071001020 Glycosyl hydrolases family 32 C terminal; Region: Glyco_hydro_32C; pfam08244 1155071001021 PTS system, sucrose-specific IIBC component; Region: PTS-II-BC-sucr; TIGR01996 1155071001022 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 1155071001023 active site turn [active] 1155071001024 phosphorylation site [posttranslational modification] 1155071001025 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 1155071001026 PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_glc; cd00210 1155071001027 HPr interaction site; other site 1155071001028 glycerol kinase (GK) interaction site [polypeptide binding]; other site 1155071001029 active site 1155071001030 phosphorylation site [posttranslational modification] 1155071001031 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 1155071001032 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 1155071001033 nucleotide binding site [chemical binding]; other site 1155071001034 Phosphomannose isomerase [Carbohydrate transport and metabolism]; Region: ManA; COG1482 1155071001035 mannose-6-phosphate isomerase, class I; Region: manA; TIGR00218 1155071001036 preprotein translocase subunit SecA; Reviewed; Region: PRK12904 1155071001037 SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958 1155071001038 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1155071001039 nucleotide binding region [chemical binding]; other site 1155071001040 ATP-binding site [chemical binding]; other site 1155071001041 SEC-C motif; Region: SEC-C; pfam02810 1155071001042 3-deoxy-D-arabino-heptulosonate 7-phosphate (DAHP) synthase [Amino acid transport and metabolism]; Region: AroG; cl17260 1155071001043 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 1155071001044 phospho-2-dehydro-3-deoxyheptonate aldolase; Provisional; Region: PRK12755 1155071001045 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 1155071001046 4'-phosphopantetheinyl transferase; Provisional; Region: acpS; PRK00070 1155071001047 alanine racemase; Reviewed; Region: alr; PRK00053 1155071001048 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430 1155071001049 active site 1155071001050 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 1155071001051 dimer interface [polypeptide binding]; other site 1155071001052 substrate binding site [chemical binding]; other site 1155071001053 catalytic residues [active] 1155071001054 ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917 1155071001055 RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488 1155071001056 generic binding surface II; other site 1155071001057 ssDNA binding site; other site 1155071001058 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1155071001059 ATP binding site [chemical binding]; other site 1155071001060 putative Mg++ binding site [ion binding]; other site 1155071001061 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1155071001062 nucleotide binding region [chemical binding]; other site 1155071001063 ATP-binding site [chemical binding]; other site 1155071001064 Type II (periplasmic) bacterial L-asparaginase; Region: L-asparaginase_II; cd08964 1155071001065 active site 1155071001066 homodimer interface [polypeptide binding]; other site 1155071001067 homotetramer interface [polypeptide binding]; other site 1155071001068 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1155071001069 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 1155071001070 active site 1155071001071 motif I; other site 1155071001072 motif II; other site 1155071001073 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1155071001074 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4696 1155071001075 metal binding site [ion binding]; metal-binding site 1155071001076 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 1155071001077 Ligand Binding Site [chemical binding]; other site 1155071001078 BioY family; Region: BioY; pfam02632 1155071001079 aminotransferase AlaT; Validated; Region: PRK09265 1155071001080 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1155071001081 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1155071001082 homodimer interface [polypeptide binding]; other site 1155071001083 catalytic residue [active] 1155071001084 transcriptional repressor CodY; Validated; Region: PRK04158 1155071001085 CodY GAF-like domain; Region: CodY; pfam06018 1155071001086 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1155071001087 dimerization interface [polypeptide binding]; other site 1155071001088 putative Zn2+ binding site [ion binding]; other site 1155071001089 putative DNA binding site [nucleotide binding]; other site 1155071001090 Isochorismatase family; Region: Isochorismatase; pfam00857 1155071001091 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 1155071001092 catalytic triad [active] 1155071001093 conserved cis-peptide bond; other site 1155071001094 aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476 1155071001095 EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317 1155071001096 dimer interface [polypeptide binding]; other site 1155071001097 anticodon binding site; other site 1155071001098 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777 1155071001099 homodimer interface [polypeptide binding]; other site 1155071001100 motif 1; other site 1155071001101 active site 1155071001102 motif 2; other site 1155071001103 GAD domain; Region: GAD; pfam02938 1155071001104 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 1155071001105 active site 1155071001106 motif 3; other site 1155071001107 aspartyl/glutamyl-tRNA amidotransferase subunit C; Reviewed; Region: gatC; PRK00034 1155071001108 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 1155071001109 aspartyl/glutamyl-tRNA amidotransferase subunit A; Reviewed; Region: gatA; PRK00012 1155071001110 aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477 1155071001111 GatB/GatE catalytic domain; Region: GatB_N; pfam02934 1155071001112 GatB domain; Region: GatB_Yqey; pfam02637 1155071001113 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 1155071001114 EamA-like transporter family; Region: EamA; pfam00892 1155071001115 This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784 1155071001116 glycosyltransferase, MGT family; Region: MGT; TIGR01426 1155071001117 active site 1155071001118 TDP-binding site; other site 1155071001119 acceptor substrate-binding pocket; other site 1155071001120 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1155071001121 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1155071001122 Protein of unknown function (DUF4230); Region: DUF4230; pfam14014 1155071001123 Predicted hydrolase of the HAD superfamily [General function prediction only]; Region: COG2179 1155071001124 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1155071001125 active site 1155071001126 motif I; other site 1155071001127 motif II; other site 1155071001128 GTPase YqeH; Provisional; Region: PRK13796 1155071001129 Circularly permuted YqeH GTPase; Region: YqeH; cd01855 1155071001130 GTP/Mg2+ binding site [chemical binding]; other site 1155071001131 G4 box; other site 1155071001132 G5 box; other site 1155071001133 G1 box; other site 1155071001134 Switch I region; other site 1155071001135 G2 box; other site 1155071001136 G3 box; other site 1155071001137 Switch II region; other site 1155071001138 Predicted RNA-binding protein containing KH domain, possibly ribosomal protein [Translation, ribosomal structure and biogenesis]; Region: COG1534 1155071001139 nicotinic acid mononucleotide adenylyltransferase; Provisional; Region: nadD; PRK00071 1155071001140 Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165 1155071001141 active site 1155071001142 (T/H)XGH motif; other site 1155071001143 Predicted HD superfamily hydrolase involved in NAD metabolism [Coenzyme metabolism]; Region: COG1713 1155071001144 Zn2+ binding site [ion binding]; other site 1155071001145 Mg2+ binding site [ion binding]; other site 1155071001146 Uncharacterized homolog of plant Iojap protein [Function unknown]; Region: COG0799 1155071001147 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1155071001148 S-adenosylmethionine binding site [chemical binding]; other site 1155071001149 hypothetical protein; Provisional; Region: PRK13670 1155071001150 HIGH Nucleotidyl Transferase; Region: HIGH_NTase1; cl17673 1155071001151 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 1155071001152 Helix-Turn-Helix DNA binding domain of the transcription regulators TipAL, Mta, and SkgA; Region: HTH_TipAL-Mta; cd01106 1155071001153 DNA binding residues [nucleotide binding] 1155071001154 dimer interface [polypeptide binding]; other site 1155071001155 TipAS antibiotic-recognition domain; Region: TipAS; pfam07739 1155071001156 hypothetical protein; Provisional; Region: PRK12378 1155071001157 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 1155071001158 catalytic residues [active] 1155071001159 preprotein translocase subunit YajC; Validated; Region: yajC; PRK06531 1155071001160 Undecaprenyl pyrophosphate synthase [Lipid metabolism]; Region: UppS; COG0020 1155071001161 Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cd00475 1155071001162 catalytic residue [active] 1155071001163 putative FPP diphosphate binding site; other site 1155071001164 putative FPP binding hydrophobic cleft; other site 1155071001165 dimer interface [polypeptide binding]; other site 1155071001166 putative IPP diphosphate binding site; other site 1155071001167 CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575 1155071001168 Cytidylyltransferase family; Region: CTP_transf_1; pfam01148 1155071001169 RIP metalloprotease RseP; Region: TIGR00054 1155071001170 Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020 1155071001171 active site 1155071001172 Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020 1155071001173 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 1155071001174 protein binding site [polypeptide binding]; other site 1155071001175 Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020 1155071001176 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 1155071001177 putative substrate binding region [chemical binding]; other site 1155071001178 prolyl-tRNA synthetase; Provisional; Region: PRK09194 1155071001179 Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_prok; cd00779 1155071001180 dimer interface [polypeptide binding]; other site 1155071001181 motif 1; other site 1155071001182 active site 1155071001183 motif 2; other site 1155071001184 INS is an amino acid-editing domain inserted (INS) into the bacterial class II prolyl-tRNA synthetase (ProRS) however, this CD is not exclusively bacterial. It is also found at the N-terminus of the eukaryotic/archaea-like ProRS's of yeasts and...; Region: ProRS-INS; cd04334 1155071001185 putative deacylase active site [active] 1155071001186 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 1155071001187 active site 1155071001188 motif 3; other site 1155071001189 ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding; Region: ProRS_anticodon_short; cd00861 1155071001190 anticodon binding site; other site 1155071001191 Staphylococcal protein of unknown function (DUF960); Region: DUF960; pfam06124 1155071001192 hypothetical protein; Provisional; Region: PRK13662 1155071001193 recombination regulator RecX; Provisional; Region: recX; PRK14135 1155071001194 TRAM domain; Region: TRAM; cl01282 1155071001195 SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase [Translation, ribosomal structure and biogenesis]; Region: TrmA; COG2265 1155071001196 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 1155071001197 NrdI Flavodoxin like; Region: Flavodoxin_NdrI; cl17293 1155071001198 RelB antitoxin; Region: RelB; cl01171 1155071001199 Domain of unknown function (DUF1912); Region: DUF1912; pfam08930 1155071001200 T-box; T-box leader 1155071001201 Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family [General function prediction only]; Region: COG1853 1155071001202 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 1155071001203 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 1155071001204 valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729 1155071001205 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 1155071001206 active site 1155071001207 HIGH motif; other site 1155071001208 nucleotide binding site [chemical binding]; other site 1155071001209 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 1155071001210 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 1155071001211 active site 1155071001212 KMSKS motif; other site 1155071001213 Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962 1155071001214 tRNA binding surface [nucleotide binding]; other site 1155071001215 anticodon binding site; other site 1155071001216 Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458 1155071001217 PIN (PilT N terminus) domain: Superfamily; Region: PIN_SF; cl14812 1155071001218 putative active site [active] 1155071001219 WYL domain; Region: WYL; pfam13280 1155071001220 CRISPR/Cas system-associated protein Cas3'' Region: Cas3''_I; cd09641 1155071001221 CRISPR-associated helicase Cas3 [Defense mechanisms]; Region: COG1203 1155071001222 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 1155071001223 CRISPR/Cas system-associated RAMP superfamily protein Cas5; Region: Cas5_I-C; cd09651 1155071001224 CRISPR-associated protein (Cas_Cas5); Region: Cas_Cas5d; pfam09704 1155071001225 CRISPR/Cas system-associated protein Cas8c; Region: Cas8c_I-C; cl12004 1155071001226 CRISPR/Cas system-associated RAMP superfamily protein Cas7; Region: Cas7_I-C; cl01465 1155071001227 CRISPR-associated protein Cas4 (RecB family exonuclease) [Defense mechanisms]; Region: COG1468 1155071001228 CRISPR/Cas system-associated protein Cas1; Region: Cas1_I-C; cd09721 1155071001229 CRISPR/Cas system-associated protein Cas2; Region: Cas2_I_II_III; cd09725 1155071001230 aspartate kinase; Reviewed; Region: PRK09034 1155071001231 AAK_AKiii-YclM-BS: Amino Acid Kinase Superfamily (AAK), AKiii-YclM-BS; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the lysine plus threonine-sensitive aspartokinase isoenzyme AKIII, a monofunctional class enzyme found in...; Region: AAK_AKiii-YclM-BS; cd04245 1155071001232 putative catalytic residues [active] 1155071001233 putative nucleotide binding site [chemical binding]; other site 1155071001234 putative aspartate binding site [chemical binding]; other site 1155071001235 ACT domains located C-terminal to the catalytic domain of the lysine plus threonine-sensitive aspartokinase isoenzyme AKIII; Region: ACT_AKiii-YclM-BS_1; cd04911 1155071001236 allosteric regulatory residue; other site 1155071001237 ACT domains located C-terminal to the catalytic domain of the lysine plus threonine-sensitive aspartokinase isoenzyme AKIII; Region: ACT_AKiii-YclM-BS_2; cd04916 1155071001238 Predicted phosphatase/phosphohexomutase [General function prediction only]; Region: COG0637 1155071001239 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1155071001240 motif II; other site 1155071001241 enoyl-CoA hydratase; Provisional; Region: PRK07260 1155071001242 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1155071001243 substrate binding site [chemical binding]; other site 1155071001244 oxyanion hole (OAH) forming residues; other site 1155071001245 trimer interface [polypeptide binding]; other site 1155071001246 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1155071001247 MarR family; Region: MarR_2; pfam12802 1155071001248 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352 1155071001249 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 1155071001250 dimer interface [polypeptide binding]; other site 1155071001251 active site 1155071001252 CoA binding pocket [chemical binding]; other site 1155071001253 acyl carrier protein; Provisional; Region: acpP; PRK00982 1155071001254 putative enoyl-[acyl-carrier-protein] reductase II; Region: enACPred_II; TIGR03151 1155071001255 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 1155071001256 FMN binding site [chemical binding]; other site 1155071001257 substrate binding site [chemical binding]; other site 1155071001258 putative catalytic residue [active] 1155071001259 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 1155071001260 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 1155071001261 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 1155071001262 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1155071001263 NAD(P) binding site [chemical binding]; other site 1155071001264 active site 1155071001265 3-oxoacyl-(acyl carrier protein) synthase II; Reviewed; Region: PRK07314 1155071001266 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 1155071001267 dimer interface [polypeptide binding]; other site 1155071001268 active site 1155071001269 acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated; Region: PRK06302 1155071001270 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 1155071001271 carboxyltransferase (CT) interaction site; other site 1155071001272 biotinylation site [posttranslational modification]; other site 1155071001273 FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288 1155071001274 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591 1155071001275 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 1155071001276 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 1155071001277 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 1155071001278 acetyl-CoA carboxylase subunit beta; Validated; Region: PRK05654 1155071001279 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 1155071001280 acetyl-CoA carboxylase subunit alpha; Provisional; Region: PRK12319 1155071001281 SWIM zinc finger; Region: SWIM; pfam04434 1155071001282 Bacterial SNF2 helicase associated; Region: SNF2_assoc; pfam08455 1155071001283 SNF2 family N-terminal domain; Region: SNF2_N; pfam00176 1155071001284 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1155071001285 ATP binding site [chemical binding]; other site 1155071001286 putative Mg++ binding site [ion binding]; other site 1155071001287 Superfamily II DNA and RNA helicases [DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis]; Region: SrmB; COG0513 1155071001288 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1155071001289 nucleotide binding region [chemical binding]; other site 1155071001290 ATP-binding site [chemical binding]; other site 1155071001291 UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421 1155071001292 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 1155071001293 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 1155071001294 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 1155071001295 Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247 1155071001296 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1155071001297 Coenzyme A binding pocket [chemical binding]; other site 1155071001298 YceG-like family; Region: YceG; pfam02618 1155071001299 proteins similar to Escherichia coli yceG; Region: yceG_like; cd08010 1155071001300 dimerization interface [polypeptide binding]; other site 1155071001301 transcription elongation factor GreA; Reviewed; Region: greA; PRK00226 1155071001302 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 1155071001303 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 1155071001304 OxaA-like protein precursor; Provisional; Region: PRK02463 1155071001305 60Kd inner membrane protein; Region: 60KD_IMP; cl00489 1155071001306 acylphosphatase; Provisional; Region: PRK14434 1155071001307 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 1155071001308 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032 1155071001309 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 1155071001310 Predicted HD superfamily hydrolase [General function prediction only]; Region: COG1418 1155071001311 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1155071001312 Zn2+ binding site [ion binding]; other site 1155071001313 Mg2+ binding site [ion binding]; other site 1155071001314 Integral membrane protein, interacts with FtsH [General function prediction only]; Region: COG0670 1155071001315 Bacterial BAX inhibitor (BI)-1/YccA-like proteins; Region: BI-1-like_bacterial; cd10432 1155071001316 Diaminopimelate decarboxylase [Amino acid transport and metabolism]; Region: LysA; COG0019 1155071001317 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828 1155071001318 active site 1155071001319 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 1155071001320 substrate binding site [chemical binding]; other site 1155071001321 catalytic residues [active] 1155071001322 dimer interface [polypeptide binding]; other site 1155071001323 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3763 1155071001324 glutamate racemase; Provisional; Region: PRK00865 1155071001325 putative deoxyribonucleotide triphosphate pyrophosphatase/unknown domain fusion protein; Reviewed; Region: PRK02491 1155071001326 NTPase/HAM1. This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515 1155071001327 active site 1155071001328 dimerization interface [polypeptide binding]; other site 1155071001329 Escherichia coli YfcE and related proteins, metallophosphatase domain; Region: MPP_YfcE; cd00841 1155071001330 active site 1155071001331 metal binding site [ion binding]; metal-binding site 1155071001332 homotetramer interface [polypeptide binding]; other site 1155071001333 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_30; cd04643 1155071001334 FOG: CBS domain [General function prediction only]; Region: COG0517 1155071001335 site-specific tyrosine recombinase XerD-like protein; Reviewed; Region: xerD; PRK02436 1155071001336 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 1155071001337 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 1155071001338 active site 1155071001339 catalytic residues [active] 1155071001340 DNA binding site [nucleotide binding] 1155071001341 Int/Topo IB signature motif; other site 1155071001342 segregation and condensation protein A; Reviewed; Region: scpA; PRK00104 1155071001343 segregation and condensation protein B; Reviewed; Region: scpB; PRK00135 1155071001344 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 1155071001345 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1155071001346 RNA binding surface [nucleotide binding]; other site 1155071001347 Pseudouridine synthases, RsuA subfamily; Region: PseudoU_synth_RsuA_like; cd02870 1155071001348 active site 1155071001349 hypothetical protein; Validated; Region: PRK00041 1155071001350 Trk-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: TrkG; COG0168 1155071001351 potassium uptake protein, TrkH family; Region: 2a38; TIGR00933 1155071001352 TrkA-N domain; Region: TrkA_N; pfam02254 1155071001353 potassium transporter peripheral membrane component; Reviewed; Region: trkA; PRK09496 1155071001354 TrkA-C domain; Region: TrkA_C; pfam02080 1155071001355 TrkA-N domain; Region: TrkA_N; pfam02254 1155071001356 TrkA-C domain; Region: TrkA_C; pfam02080 1155071001357 23S methyl RNA motif; 23S-methyl 1155071001358 Predicted rRNA methylase (SpoU class) [Translation, ribosomal structure and biogenesis]; Region: CspR; COG0219 1155071001359 Domain of unknown function (DUF4097); Region: DUF4097; pfam13349 1155071001360 Domain of unknown function (DUF4098); Region: DUF4098; pfam13345 1155071001361 Predicted membrane protein [Function unknown]; Region: COG4709 1155071001362 Predicted transcriptional regulators [Transcription]; Region: COG1695 1155071001363 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 1155071001364 Predicted membrane protein [Function unknown]; Region: COG3601 1155071001365 Protein of unknown function (DUF3816); Region: DUF3816; pfam12822 1155071001366 PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392 1155071001367 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 1155071001368 active site 1155071001369 Putative effector of murein hydrolase LrgA [General function prediction only]; Region: COG1380 1155071001370 LrgB-like family; Region: LrgB; pfam04172 1155071001371 Predicted Fe-S oxidoreductase [General function prediction only]; Region: COG1242 1155071001372 Putative rRNA methylase; Region: rRNA_methylase; pfam06962 1155071001373 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 1155071001374 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cd00267 1155071001375 Walker A/P-loop; other site 1155071001376 ATP binding site [chemical binding]; other site 1155071001377 Q-loop/lid; other site 1155071001378 ABC transporter signature motif; other site 1155071001379 Walker B; other site 1155071001380 D-loop; other site 1155071001381 H-loop/switch region; other site 1155071001382 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 1155071001383 Domain of unknown function DUF20; Region: UPF0118; pfam01594 1155071001384 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 1155071001385 Domain of unknown function DUF21; Region: DUF21; pfam01595 1155071001386 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 1155071001387 Transporter associated domain; Region: CorC_HlyC; smart01091 1155071001388 pyruvate formate-lyase 1-activating enzyme; Region: PFLA; TIGR02493 1155071001389 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1155071001390 FeS/SAM binding site; other site 1155071001391 D-alanine--poly(phosphoribitol) ligase subunit 1; Provisional; Region: PRK04813 1155071001392 D-alanine:D-alanyl carrier protein ligase (DltA); Region: DltA; cd05945 1155071001393 acyl-activating enzyme (AAE) consensus motif; other site 1155071001394 AMP binding site [chemical binding]; other site 1155071001395 D-alanyl-lipoteichoic acid biosynthesis protein DltB; Region: LTA_dltB; TIGR04091 1155071001396 D-alanine--poly(phosphoribitol) ligase subunit 2; Validated; Region: PRK05087 1155071001397 D-alanyl-lipoteichoic acid biosynthesis protein DltD; Region: LTA_DltD; TIGR04092 1155071001398 DltD N-terminal region; Region: DltD_N; pfam04915 1155071001399 DltD central region; Region: DltD_M; pfam04918 1155071001400 DltD C-terminal region; Region: DltD_C; pfam04914 1155071001401 putative manganese-dependent inorganic pyrophosphatase; Provisional; Region: PRK05427 1155071001402 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 1155071001403 DHHA2 domain; Region: DHHA2; pfam02833 1155071001404 Domain of unknown function (DUF1803); Region: DUF1803; pfam08820 1155071001405 Domain of unknown function (DUF1803); Region: DUF1803; pfam08820 1155071001406 Predicted transcriptional regulator [Transcription]; Region: COG2378 1155071001407 HTH domain; Region: HTH_11; pfam08279 1155071001408 WYL domain; Region: WYL; pfam13280 1155071001409 Putative intracellular protease/amidase [General function prediction only]; Region: ThiJ; COG0693 1155071001410 Type 1 glutamine amidotransferase (GATase1)-like domain found in a subgroup of proteins similar to PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_3; cd03140 1155071001411 conserved cys residue [active] 1155071001412 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_19; cd07262 1155071001413 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1155071001414 PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in bacteria and archaea; Region: PEBP_bact_arch; cd00865 1155071001415 substrate binding site [chemical binding]; other site 1155071001416 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1155071001417 BAAT / Acyl-CoA thioester hydrolase C terminal; Region: BAAT_C; pfam08840 1155071001418 UDP-N-acetylmuramoylalanyl-D-glutamate--L-lysine ligase; Provisional; Region: PRK14022 1155071001419 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 1155071001420 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 1155071001421 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 1155071001422 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 1155071001423 Stage V sporulation protein B, also known as Stage III sporulation protein F, and related proteins; Region: MATE_SpoVB_like; cd13124 1155071001424 cystathionine gamma-synthase; Reviewed; Region: PRK07269 1155071001425 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 1155071001426 homodimer interface [polypeptide binding]; other site 1155071001427 substrate-cofactor binding pocket; other site 1155071001428 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1155071001429 catalytic residue [active] 1155071001430 Bifunctional PLP-dependent enzyme with beta-cystathionase and maltose regulon repressor activities [Amino acid transport and metabolism]; Region: MalY; COG1168 1155071001431 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1155071001432 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1155071001433 homodimer interface [polypeptide binding]; other site 1155071001434 catalytic residue [active] 1155071001435 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1155071001436 active site 1155071001437 Protease subunit of ATP-dependent Clp proteases [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: ClpP; COG0740 1155071001438 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 1155071001439 oligomer interface [polypeptide binding]; other site 1155071001440 active site residues [active] 1155071001441 Protein of unknown function (DUF964); Region: DUF964; pfam06133 1155071001442 hypothetical protein; Provisional; Region: PRK02302 1155071001443 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 1155071001444 Type I periplasmic ligand-binding domain of uncharacterized ABC (Atpase Binding Cassette)-type active transport systems that are predicted to be involved in uptake of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_ligand_binding_like_12; cd06347 1155071001445 putative ligand binding site [chemical binding]; other site 1155071001446 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 1155071001447 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 1155071001448 TM-ABC transporter signature motif; other site 1155071001449 ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177 1155071001450 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 1155071001451 TM-ABC transporter signature motif; other site 1155071001452 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 1155071001453 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 1155071001454 Walker A/P-loop; other site 1155071001455 ATP binding site [chemical binding]; other site 1155071001456 Q-loop/lid; other site 1155071001457 ABC transporter signature motif; other site 1155071001458 Walker B; other site 1155071001459 D-loop; other site 1155071001460 H-loop/switch region; other site 1155071001461 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 1155071001462 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 1155071001463 Walker A/P-loop; other site 1155071001464 ATP binding site [chemical binding]; other site 1155071001465 Q-loop/lid; other site 1155071001466 ABC transporter signature motif; other site 1155071001467 Walker B; other site 1155071001468 D-loop; other site 1155071001469 H-loop/switch region; other site 1155071001470 FOG: CBS domain [General function prediction only]; Region: COG0517 1155071001471 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the acetoin utilization proteins in bacteria. Acetoin is a product of fermentative metabolism in many prokaryotic and eukaryotic microorganisms. They produce...; Region: CBS_pair_ACT_assoc2; cd04585 1155071001472 thymidylate kinase; Validated; Region: tmk; PRK00698 1155071001473 Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672 1155071001474 TMP-binding site; other site 1155071001475 ATP-binding site [chemical binding]; other site 1155071001476 DNA polymerase III subunit delta'; Validated; Region: PRK07276 1155071001477 DNA polymerase III subunit delta'; Validated; Region: PRK08485 1155071001478 Uncharacterized homolog of PSP1 [Function unknown]; Region: COG1774 1155071001479 DNA replication intiation control protein YabA; Reviewed; Region: PRK13169 1155071001480 Predicted methyltransferases [General function prediction only]; Region: COG0313 1155071001481 Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648 1155071001482 putative SAM binding site [chemical binding]; other site 1155071001483 putative homodimer interface [polypeptide binding]; other site 1155071001484 Ammonia permease [Inorganic ion transport and metabolism]; Region: AmtB; COG0004 1155071001485 Nitrogen regulatory protein PII [Amino acid transport and metabolism]; Region: GlnK; COG0347 1155071001486 Nitrogen regulatory protein P-II; Region: P-II; smart00938 1155071001487 3-phosphoserine/phosphohydroxythreonine aminotransferase; Provisional; Region: PRK05355 1155071001488 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 1155071001489 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1155071001490 catalytic residue [active] 1155071001491 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cl10015 1155071001492 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 1155071001493 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1155071001494 Coenzyme A binding pocket [chemical binding]; other site 1155071001495 Putative D-3-Phosphoglycerate Dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_like_3; cd12174 1155071001496 D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain; Region: 2-Hacid_dh; pfam00389 1155071001497 putative ligand binding site [chemical binding]; other site 1155071001498 putative NAD binding site [chemical binding]; other site 1155071001499 putative catalytic site [active] 1155071001500 C-terminal ACT (regulatory) domain of D-3-Phosphoglycerate Dehydrogenase (3PGDH) found in fungi and bacteria; Region: ACT_3PGDH; cd04901 1155071001501 L-serine binding site [chemical binding]; other site 1155071001502 ACT domain interface; other site 1155071001503 Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350 1155071001504 6-O-methylguanine DNA methyltransferase, ribonuclease-like domain; Region: Methyltransf_1N; pfam02870 1155071001505 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 1155071001506 DNA binding site [nucleotide binding] 1155071001507 active site 1155071001508 Arsenate Reductase (ArsC) family, unknown subfamily; uncharacterized proteins containing a CXXC motif with similarity to thioredoxin (TRX)-fold arsenic reductases, ArsC. Proteins containing a redox active CXXC motif like TRX and glutaredoxin (GRX)...; Region: ArsC_like; cd03036 1155071001509 ArsC family; Region: ArsC; pfam03960 1155071001510 putative ArsC-like catalytic residues; other site 1155071001511 putative TRX-like catalytic residues [active] 1155071001512 Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177 1155071001513 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 1155071001514 minor groove reading motif; other site 1155071001515 helix-hairpin-helix signature motif; other site 1155071001516 substrate binding pocket [chemical binding]; other site 1155071001517 active site 1155071001518 Human Ape1-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: Ape1-like_AP-endo; cd09087 1155071001519 active site 1155071001520 putative catalytic site [active] 1155071001521 DNA binding site [nucleotide binding] 1155071001522 putative phosphate binding site [ion binding]; other site 1155071001523 metal binding site A [ion binding]; metal-binding site 1155071001524 AP binding site [nucleotide binding]; other site 1155071001525 metal binding site B [ion binding]; metal-binding site 1155071001526 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1155071001527 dimerization interface [polypeptide binding]; other site 1155071001528 putative DNA binding site [nucleotide binding]; other site 1155071001529 putative Zn2+ binding site [ion binding]; other site 1155071001530 Protein of unknown function (DUF1648); Region: DUF1648; pfam07853 1155071001531 SdpI/YhfL protein family; Region: SdpI; pfam13630 1155071001532 tellurite resistance protein TehB; Provisional; Region: PRK12335 1155071001533 Domain of unknown function (DUF1971); Region: DUF1971; pfam09313 1155071001534 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1155071001535 S-adenosylmethionine binding site [chemical binding]; other site 1155071001536 Protein of unknown function (DUF3290); Region: DUF3290; pfam11694 1155071001537 Predicted membrane protein [Function unknown]; Region: COG2323 1155071001538 methionyl-tRNA synthetase; Reviewed; Region: PRK12267 1155071001539 catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814 1155071001540 active site 1155071001541 HIGH motif; other site 1155071001542 KMSKS motif; other site 1155071001543 Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957 1155071001544 tRNA binding surface [nucleotide binding]; other site 1155071001545 anticodon binding site; other site 1155071001546 tRNA-binding-domain-containing Escherichia coli methionyl-tRNA synthetase (EcMetRS)-like proteins. This family includes EcMetRS and Aquifex aeolicus Trbp111 (AaTrbp111). This domain has general tRNA binding properties. MetRS aminoacylates methionine...; Region: tRNA_bind_EcMetRS_like; cd02800 1155071001547 dimer interface [polypeptide binding]; other site 1155071001548 putative tRNA-binding site [nucleotide binding]; other site 1155071001549 ASC-1 homology domain, subfamily similar to Enterococcus faecalis Ef3133. The ASCH domain, a small beta-barrel domain found in all three kingdoms of life, resembles the RNA-binding PUA domain and may also interact with RNA. ASCH has been proposed to...; Region: ASCH_Ef3133_like; cd06553 1155071001550 bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase; Provisional; Region: glmU; PRK14354 1155071001551 N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540 1155071001552 Substrate binding site; other site 1155071001553 Mg++ binding site; other site 1155071001554 N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353 1155071001555 active site 1155071001556 substrate binding site [chemical binding]; other site 1155071001557 CoA binding site [chemical binding]; other site 1155071001558 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 1155071001559 dimer interface [polypeptide binding]; other site 1155071001560 ADP-ribose binding site [chemical binding]; other site 1155071001561 active site 1155071001562 nudix motif; other site 1155071001563 metal binding site [ion binding]; metal-binding site 1155071001564 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Validated; Region: PRK05584 1155071001565 Peptidyl-prolyl cis-trans isomerase (rotamase) - cyclophilin family [Posttranslational modification, protein turnover, chaperones]; Region: PpiB; COG0652 1155071001566 active site 1155071001567 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 1155071001568 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 1155071001569 This domain directs oriented DNA translocation and forms a winged helix structure; Region: Ftsk_gamma; smart00843 1155071001570 Protein of unknown function (DUF3397); Region: DUF3397; pfam11877 1155071001571 50S ribosomal protein L11; Validated; Region: rplK; PRK00140 1155071001572 Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349 1155071001573 23S rRNA interface [nucleotide binding]; other site 1155071001574 L7/L12 interface [polypeptide binding]; other site 1155071001575 putative thiostrepton binding site; other site 1155071001576 L25 interface [polypeptide binding]; other site 1155071001577 Ribosomal protein L1. The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA. In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403 1155071001578 mRNA/rRNA interface [nucleotide binding]; other site 1155071001579 UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254 1155071001580 putative nucleotide binding site [chemical binding]; other site 1155071001581 uridine monophosphate binding site [chemical binding]; other site 1155071001582 homohexameric interface [polypeptide binding]; other site 1155071001583 ribosome recycling factor; Reviewed; Region: frr; PRK00083 1155071001584 Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation. Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520 1155071001585 hinge region; other site 1155071001586 Predicted RNA-bindining protein (contains S1 and HTH domains) [General function prediction only]; Region: COG2996 1155071001587 S1 domain; Region: S1_2; pfam13509 1155071001588 Ribosomal protein S1-like RNA-binding domain; Region: S1; smart00316 1155071001589 methionine sulfoxide reductase A; Provisional; Region: PRK14054 1155071001590 hypothetical protein; Provisional; Region: PRK13672 1155071001591 Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702 1155071001592 PhoH-like protein; Region: PhoH; pfam02562 1155071001593 metal-binding heat shock protein; Provisional; Region: PRK00016 1155071001594 Diacylglycerol kinase [Cell envelope biogenesis, outer membrane]; Region: DgkA; COG0818 1155071001595 GTPase Era; Reviewed; Region: era; PRK00089 1155071001596 E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163 1155071001597 G1 box; other site 1155071001598 GTP/Mg2+ binding site [chemical binding]; other site 1155071001599 Switch I region; other site 1155071001600 G2 box; other site 1155071001601 Switch II region; other site 1155071001602 G3 box; other site 1155071001603 G4 box; other site 1155071001604 G5 box; other site 1155071001605 KH domain; Region: KH_2; pfam07650 1155071001606 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_18; cd04677 1155071001607 nudix motif; other site 1155071001608 DinB superfamily; Region: DinB_2; pfam12867 1155071001609 formamidopyrimidine/5-formyluracil/ 5-hydroxymethyluracil DNA glycosylase; Validated; Region: PRK01103 1155071001610 N-terminal domain of Escherichia coli Fpg1/MutM and related bacterial DNA glycosylases; Region: EcFpg-like_N; cd08966 1155071001611 DNA binding site [nucleotide binding] 1155071001612 catalytic residue [active] 1155071001613 H2TH interface [polypeptide binding]; other site 1155071001614 putative catalytic residues [active] 1155071001615 turnover-facilitating residue; other site 1155071001616 intercalation triad [nucleotide binding]; other site 1155071001617 8OG recognition residue [nucleotide binding]; other site 1155071001618 putative reading head residues; other site 1155071001619 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 1155071001620 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 1155071001621 Dephospho-CoA kinase [Coenzyme metabolism]; Region: CoaE; COG0237 1155071001622 Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022 1155071001623 CoA-binding site [chemical binding]; other site 1155071001624 ATP-binding [chemical binding]; other site 1155071001625 drug efflux system protein MdtG; Provisional; Region: PRK09874 1155071001626 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1155071001627 putative substrate translocation pore; other site 1155071001628 50S ribosomal protein L33; Validated; Region: rpmG; PRK00595 1155071001629 preprotein translocase subunit SecG; Reviewed; Region: secG; PRK06870 1155071001630 ribonuclease R; Region: RNase_R; TIGR02063 1155071001631 Ribonuclease B OB domain; Region: OB_RNB; pfam08206 1155071001632 RNB domain; Region: RNB; pfam00773 1155071001633 S1_RNase_R: RNase R C-terminal S1 domain. RNase R is a processive 3' to 5' exoribonuclease, which is a homolog of RNase II. RNase R degrades RNA with secondary structure having a 3' overhang of at least 7 nucleotides. RNase R and PNPase...; Region: S1_RNase_R; cd04471 1155071001634 RNA binding site [nucleotide binding]; other site 1155071001635 Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294 1155071001636 SmpB-tmRNA interface; other site 1155071001637 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1155071001638 Glyoxalase I catalyzes the isomerization of the hemithioacetal, formed by a 2-oxoaldehyde and glutathione, to S-D-lactoylglutathione; Region: Glyoxalase_I; cd07233 1155071001639 dimer interface [polypeptide binding]; other site 1155071001640 active site 1155071001641 metal binding site [ion binding]; metal-binding site 1155071001642 glutathione binding site [chemical binding]; other site 1155071001643 NAD(P)H:FMN oxidoreductase family. This domain catalyzes the reduction of flavin, nitrocompound, quinones and azo compounds using NADH or NADPH as an electron donor. The enzyme is a homodimer, and each monomer binds a FMN as co-factor. This family...; Region: NfsB_like_nitroreductase; cd02149 1155071001644 dimer interface [polypeptide binding]; other site 1155071001645 FMN binding site [chemical binding]; other site 1155071001646 6-phospho-beta-glucosidase; Reviewed; Region: celA; PRK09589 1155071001647 beta-galactosidase; Region: BGL; TIGR03356 1155071001648 cellobiose phosphotransferase system IIB component; Reviewed; Region: celB; PRK09590 1155071001649 active site 1155071001650 P-loop; other site 1155071001651 phosphorylation site [posttranslational modification] 1155071001652 Transcriptional antiterminator [Transcription]; Region: BglG; COG3711 1155071001653 HTH domain; Region: HTH_11; pfam08279 1155071001654 Mga helix-turn-helix domain; Region: Mga; pfam05043 1155071001655 PRD domain; Region: PRD; pfam00874 1155071001656 PRD domain; Region: PRD; pfam00874 1155071001657 PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568 1155071001658 active site 1155071001659 P-loop; other site 1155071001660 phosphorylation site [posttranslational modification] 1155071001661 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cl00163 1155071001662 active site 1155071001663 phosphorylation site [posttranslational modification] 1155071001664 PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_lac; cd00215 1155071001665 methionine cluster; other site 1155071001666 active site 1155071001667 phosphorylation site [posttranslational modification] 1155071001668 metal binding site [ion binding]; metal-binding site 1155071001669 cellobiose phosphotransferase system IIC component; Reviewed; Region: celD; PRK09592 1155071001670 Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455 1155071001671 Carbonic anhydrase [Inorganic ion transport and metabolism]; Region: Cah; COG3338 1155071001672 Carbonic anhydrase alpha, prokaryotic-like subfamily. Carbonic anhydrases (CAs) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism: a nucleophilic attack of a zinc-bound hydroxide ion on carbon...; Region: alpha_CA_prokaryotic_like; cd03124 1155071001673 active site 1155071001674 zinc binding site [ion binding]; other site 1155071001675 CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575 1155071001676 Putative integral membrane protein DUF46; Region: DUF46; cl17511 1155071001677 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 1155071001678 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 1155071001679 Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092 1155071001680 active site 1155071001681 catabolite control protein A; Region: ccpA; TIGR01481 1155071001682 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1155071001683 DNA binding site [nucleotide binding] 1155071001684 domain linker motif; other site 1155071001685 Ligand-binding domain of the catabolite control protein A (CcpA), which functions as the major transcriptional regulator of carbon catabolite repression/regulation; Region: PBP1_CcpA_like; cd06298 1155071001686 dimerization interface [polypeptide binding]; other site 1155071001687 effector binding site; other site 1155071001688 cytoplasmic alpha-amylase; Reviewed; Region: PRK09441 1155071001689 Alpha amylase catalytic domain found in bacterial and fungal Alpha amylases (also called 1,4-alpha-D-glucan-4-glucanohydrolase); Region: AmyAc_bac_fung_AmyA; cd11318 1155071001690 active site 1155071001691 Na/Ca binding site [ion binding]; other site 1155071001692 catalytic site [active] 1155071001693 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 1155071001694 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1155071001695 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1155071001696 This family is most closely related to the GT1 family of glycosyltransferases. UDP-glucose-diacylglycerol glucosyltransferase (UGDG; also known as 1,2-diacylglycerol 3-glucosyltransferase) catalyzes the transfer of glucose from UDP-glucose to 1; Region: GT1_UGDG_like; cd03817 1155071001697 putative ADP-binding pocket [chemical binding]; other site 1155071001698 AAA domain; Region: AAA_17; pfam13207 1155071001699 threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK00413 1155071001700 TGS _ThrRS_N: ThrRS (threonyl-tRNA Synthetase) is a class II tRNA synthetase that couples threonine to its cognate tRNA. In addition to its catalytic and anticodon-binding domains, ThrRS has an N-terminal TGS domain, named after the ThrRS, GTPase, and...; Region: TGS_ThrRS_N; cd01667 1155071001701 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; pfam07973 1155071001702 Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771 1155071001703 active site 1155071001704 dimer interface [polypeptide binding]; other site 1155071001705 motif 1; other site 1155071001706 motif 2; other site 1155071001707 motif 3; other site 1155071001708 ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860 1155071001709 anticodon binding site; other site 1155071001710 probable dihydroxyacetone kinase regulator; Region: DHAK_reg; TIGR02366 1155071001711 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1155071001712 myosin-cross-reactive antigen; Provisional; Region: PRK13977 1155071001713 GAF domain-containing protein [Signal transduction mechanisms]; Region: COG1956 1155071001714 DNA polymerase III subunits gamma and tau; Validated; Region: PRK05563 1155071001715 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1155071001716 Walker A motif; other site 1155071001717 ATP binding site [chemical binding]; other site 1155071001718 Walker B motif; other site 1155071001719 arginine finger; other site 1155071001720 DNA polymerase III subunits gamma and tau domain III; Region: DNA_pol3_gamma3; pfam12169 1155071001721 Protein of unknown function (DUF3272); Region: DUF3272; pfam11676 1155071001722 Biotin operon repressor [Transcription]; Region: BirA; COG1654 1155071001723 bifunctional biotin--[acetyl-CoA-carboxylase] synthetase/biotin operon repressor; Provisional; Region: PRK11886 1155071001724 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; pfam03099 1155071001725 Biotin protein ligase C terminal domain; Region: BPL_C; pfam02237 1155071001726 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1155071001727 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 1155071001728 Walker A motif; other site 1155071001729 ATP binding site [chemical binding]; other site 1155071001730 Walker B motif; other site 1155071001731 arginine finger; other site 1155071001732 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1155071001733 motif II; other site 1155071001734 S-adenosylmethionine synthetase; Validated; Region: PRK05250 1155071001735 S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438 1155071001736 S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772 1155071001737 S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773 1155071001738 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 1155071001739 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 1155071001740 hinge; other site 1155071001741 active site 1155071001742 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 1155071001743 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 1155071001744 Walker A/P-loop; other site 1155071001745 ATP binding site [chemical binding]; other site 1155071001746 Q-loop/lid; other site 1155071001747 ABC transporter signature motif; other site 1155071001748 Walker B; other site 1155071001749 D-loop; other site 1155071001750 H-loop/switch region; other site 1155071001751 TOBE domain; Region: TOBE_2; pfam08402 1155071001752 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 1155071001753 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1155071001754 dimer interface [polypeptide binding]; other site 1155071001755 conserved gate region; other site 1155071001756 putative PBP binding loops; other site 1155071001757 ABC-ATPase subunit interface; other site 1155071001758 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1155071001759 dimer interface [polypeptide binding]; other site 1155071001760 conserved gate region; other site 1155071001761 ABC-ATPase subunit interface; other site 1155071001762 Maltose-binding periplasmic proteins/domains [Carbohydrate transport and metabolism]; Region: MalE; COG2182 1155071001763 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 1155071001764 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1155071001765 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1155071001766 DNA binding site [nucleotide binding] 1155071001767 domain linker motif; other site 1155071001768 Ligand-binding domain of uncharacterized transcription regulator ycjW which is a member of the LacI-GalR family repressors; Region: PBP1_ycjW_transcription_regulator_like; cd06294 1155071001769 putative dimerization interface [polypeptide binding]; other site 1155071001770 putative ligand binding site [chemical binding]; other site 1155071001771 4-alpha-glucanotransferase; Provisional; Region: PRK14508 1155071001772 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 1155071001773 glycogen/starch/alpha-glucan phosphorylases; Region: P_ylase; TIGR02093 1155071001774 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 1155071001775 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; pfam00690 1155071001776 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 1155071001777 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 1155071001778 Soluble P-type ATPase [General function prediction only]; Region: COG4087 1155071001779 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 1155071001780 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 1155071001781 TrkA-N domain; Region: TrkA_N; pfam02254 1155071001782 TrkA-C domain; Region: TrkA_C; pfam02080 1155071001783 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 1155071001784 TrkA-N domain; Region: TrkA_N; pfam02254 1155071001785 TrkA-C domain; Region: TrkA_C; pfam02080 1155071001786 Predicted membrane protein [Function unknown]; Region: COG2510 1155071001787 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 1155071001788 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 1155071001789 Predicted transcriptional regulator containing CBS domains [Transcription]; Region: COG4109 1155071001790 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1155071001791 DNA-binding site [nucleotide binding]; DNA binding site 1155071001792 DRTGG domain; Region: DRTGG; pfam07085 1155071001793 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with a DRTGG domain upstream. The function of the DRTGG domain, named after its conserved residues, is unknown. CBS is a small domain originally...; Region: CBS_pair_DRTGG_assoc; cd04596 1155071001794 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 1155071001795 active site 1155071001796 Ribonuclease BN family enzyme [Replication, recombination, and repair]; Region: Rbn; COG1295 1155071001797 EXLDI protein; Region: EXLDI; TIGR04342 1155071001798 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 1155071001799 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 1155071001800 Walker A/P-loop; other site 1155071001801 ATP binding site [chemical binding]; other site 1155071001802 Q-loop/lid; other site 1155071001803 ABC transporter signature motif; other site 1155071001804 Walker B; other site 1155071001805 D-loop; other site 1155071001806 H-loop/switch region; other site 1155071001807 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 1155071001808 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 1155071001809 Histidine kinase; Region: HisKA_3; pfam07730 1155071001810 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1155071001811 ATP binding site [chemical binding]; other site 1155071001812 Mg2+ binding site [ion binding]; other site 1155071001813 G-X-G motif; other site 1155071001814 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1155071001815 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1155071001816 active site 1155071001817 phosphorylation site [posttranslational modification] 1155071001818 intermolecular recognition site; other site 1155071001819 dimerization interface [polypeptide binding]; other site 1155071001820 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1155071001821 DNA binding residues [nucleotide binding] 1155071001822 dimerization interface [polypeptide binding]; other site 1155071001823 Predicted membrane protein [Function unknown]; Region: COG2246 1155071001824 GtrA-like protein; Region: GtrA; pfam04138 1155071001825 Predicted membrane protein [Function unknown]; Region: COG4708 1155071001826 NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956 1155071001827 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114 1155071001828 nucleotide binding pocket [chemical binding]; other site 1155071001829 K-X-D-G motif; other site 1155071001830 catalytic site [active] 1155071001831 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 1155071001832 NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119 1155071001833 Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027 1155071001834 Dimer interface [polypeptide binding]; other site 1155071001835 BRCT sequence motif; other site 1155071001836 putative lipid kinase; Reviewed; Region: PRK13055 1155071001837 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 1155071001838 Family 41 Carbohydrate-Binding Module from pullulanase-like enzymes; Region: CBM41_pullulanase; cl04227 1155071001839 carbohydrate binding site [chemical binding]; other site 1155071001840 pullulanase, type I; Region: pulA_typeI; TIGR02104 1155071001841 Early set domain associated with the catalytic domain of pullulanase (also called dextrinase and alpha-dextrin endo-1,6-alpha glucosidase); Region: E_set_Pullulanase; cd02860 1155071001842 Alpha amylase catalytic domain found in Pullulanase (also called dextrinase; alpha-dextrin endo-1,6-alpha glucosidase), limit dextrinase, and related proteins; Region: AmyAc_Pullulanase_LD-like; cd11341 1155071001843 Ca binding site [ion binding]; other site 1155071001844 active site 1155071001845 catalytic site [active] 1155071001846 glycogen branching enzyme; Provisional; Region: PRK12313 1155071001847 N-terminal Early set domain associated with the catalytic domain of prokaryotic glycogen branching enzyme; Region: E_set_GBE_prok_N; cd02855 1155071001848 Alpha amylase catalytic domain found in the Glycogen branching enzyme (also called 1,4-alpha-glucan branching enzyme); Region: AmyAc_Glg_BE; cd11322 1155071001849 active site 1155071001850 catalytic site [active] 1155071001851 Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; pfam02806 1155071001852 glucose-1-phosphate adenylyltransferase; Provisional; Region: glgC; PRK05293 1155071001853 ADP-glucose pyrophosphorylase is involved in the biosynthesis of glycogen or starch; Region: ADP_Glucose_PP; cd02508 1155071001854 ligand binding site; other site 1155071001855 oligomer interface; other site 1155071001856 Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651 1155071001857 dimer interface [polypeptide binding]; other site 1155071001858 N-terminal domain interface [polypeptide binding]; other site 1155071001859 sulfate 1 binding site; other site 1155071001860 glucose-1-phosphate adenylyltransferase, GlgD subunit; Region: glgD; TIGR02092 1155071001861 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 1155071001862 active site 1155071001863 Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651 1155071001864 dimer interface [polypeptide binding]; other site 1155071001865 N-terminal domain interface [polypeptide binding]; other site 1155071001866 sulfate 1 binding site; other site 1155071001867 glycogen synthase; Provisional; Region: glgA; PRK00654 1155071001868 This family is most closely related to the GT1 family of glycosyltransferases. Glycogen synthase catalyzes the formation and elongation of the alpha-1,4-glucose backbone using ADP-glucose, the second and key step of glycogen biosynthesis. This family...; Region: GT1_Glycogen_synthase_DULL1_like; cd03791 1155071001869 ADP-binding pocket [chemical binding]; other site 1155071001870 homodimer interface [polypeptide binding]; other site 1155071001871 This is a family of oligosaccharide phosphorylases. It includes yeast and mammalian glycogen phosphorylases, plant starch/glucan phosphorylase, as well as the maltodextrin phosphorylases of bacteria. The members of this family catalyze the breakdown of...; Region: GT1_Glycogen_Phosphorylase; cd04300 1155071001872 homodimer interface [polypeptide binding]; other site 1155071001873 glycogen/starch/alpha-glucan phosphorylases; Region: P_ylase; TIGR02093 1155071001874 active site pocket [active] 1155071001875 F0F1 ATP synthase subunit C; Provisional; Region: PRK13467 1155071001876 F0F1 ATP synthase subunit A; Validated; Region: PRK05815 1155071001877 F0F1-type ATP synthase, subunit a [Energy production and conversion]; Region: AtpB; COG0356 1155071001878 F0F1-type ATP synthase, subunit b [Energy production and conversion]; Region: AtpF; COG0711 1155071001879 ATP synthase, F0 subunit b; Region: ATP_synt_b; TIGR01144 1155071001880 F0F1 ATP synthase subunit delta; Validated; Region: PRK05758 1155071001881 ATP synthase delta (OSCP) subunit; Region: OSCP; pfam00213 1155071001882 F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281 1155071001883 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 1155071001884 F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132 1155071001885 beta subunit interaction interface [polypeptide binding]; other site 1155071001886 Walker A motif; other site 1155071001887 ATP binding site [chemical binding]; other site 1155071001888 Walker B motif; other site 1155071001889 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 1155071001890 mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151 1155071001891 core domain interface [polypeptide binding]; other site 1155071001892 delta subunit interface [polypeptide binding]; other site 1155071001893 epsilon subunit interface [polypeptide binding]; other site 1155071001894 F0F1 ATP synthase subunit beta; Validated; Region: PRK09280 1155071001895 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 1155071001896 F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133 1155071001897 alpha subunit interaction interface [polypeptide binding]; other site 1155071001898 Walker A motif; other site 1155071001899 ATP binding site [chemical binding]; other site 1155071001900 Walker B motif; other site 1155071001901 inhibitor binding site; inhibition site 1155071001902 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 1155071001903 F0F1 ATP synthase subunit epsilon; Validated; Region: atpC; PRK00571 1155071001904 mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152 1155071001905 gamma subunit interface [polypeptide binding]; other site 1155071001906 epsilon subunit interface [polypeptide binding]; other site 1155071001907 LBP interface [polypeptide binding]; other site 1155071001908 Protein of unknown function (DUF1146); Region: DUF1146; cl11486 1155071001909 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 1155071001910 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 1155071001911 hinge; other site 1155071001912 active site 1155071001913 DNA-directed RNA polymerase subunit beta; Region: EpuA; pfam11772 1155071001914 DNA/RNA non-specific endonuclease; Region: Endonuclease_NS; smart00892 1155071001915 DNA/RNA non-specific endonuclease; Region: Endonuclea_NS_2; cl17626 1155071001916 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1155071001917 dimer interface [polypeptide binding]; other site 1155071001918 conserved gate region; other site 1155071001919 putative PBP binding loops; other site 1155071001920 ABC-ATPase subunit interface; other site 1155071001921 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1155071001922 dimer interface [polypeptide binding]; other site 1155071001923 conserved gate region; other site 1155071001924 putative PBP binding loops; other site 1155071001925 ABC-ATPase subunit interface; other site 1155071001926 bifunctional adhesin/ABC transporter aspartate/glutamate-binding protein; Reviewed; Region: PRK11917 1155071001927 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1155071001928 substrate binding pocket [chemical binding]; other site 1155071001929 membrane-bound complex binding site; other site 1155071001930 hinge residues; other site 1155071001931 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 1155071001932 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 1155071001933 Walker A/P-loop; other site 1155071001934 ATP binding site [chemical binding]; other site 1155071001935 Q-loop/lid; other site 1155071001936 ABC transporter signature motif; other site 1155071001937 Walker B; other site 1155071001938 D-loop; other site 1155071001939 H-loop/switch region; other site 1155071001940 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1155071001941 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1155071001942 active site 1155071001943 phosphorylation site [posttranslational modification] 1155071001944 intermolecular recognition site; other site 1155071001945 dimerization interface [polypeptide binding]; other site 1155071001946 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1155071001947 DNA binding site [nucleotide binding] 1155071001948 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 1155071001949 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1155071001950 putative active site [active] 1155071001951 heme pocket [chemical binding]; other site 1155071001952 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1155071001953 dimer interface [polypeptide binding]; other site 1155071001954 phosphorylation site [posttranslational modification] 1155071001955 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1155071001956 ATP binding site [chemical binding]; other site 1155071001957 Mg2+ binding site [ion binding]; other site 1155071001958 G-X-G motif; other site 1155071001959 Metal-dependent hydrolases of the beta-lactamase superfamily I [General function prediction only]; Region: PhnP; COG1235 1155071001960 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 1155071001961 ribonuclease III; Reviewed; Region: rnc; PRK00102 1155071001962 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 1155071001963 dimerization interface [polypeptide binding]; other site 1155071001964 active site 1155071001965 metal binding site [ion binding]; metal-binding site 1155071001966 Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048 1155071001967 dsRNA binding site [nucleotide binding]; other site 1155071001968 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 1155071001969 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 1155071001970 Walker A/P-loop; other site 1155071001971 ATP binding site [chemical binding]; other site 1155071001972 Q-loop/lid; other site 1155071001973 SMC proteins Flexible Hinge Domain; Region: SMC_hinge; smart00968 1155071001974 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 1155071001975 ABC transporter signature motif; other site 1155071001976 Walker B; other site 1155071001977 D-loop; other site 1155071001978 H-loop/switch region; other site 1155071001979 phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488 1155071001980 Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912 1155071001981 Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496 1155071001982 dimer interface [polypeptide binding]; other site 1155071001983 motif 1; other site 1155071001984 active site 1155071001985 motif 2; other site 1155071001986 motif 3; other site 1155071001987 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 1155071001988 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1155071001989 Coenzyme A binding pocket [chemical binding]; other site 1155071001990 phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629 1155071001991 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 1155071001992 putative tRNA-binding site [nucleotide binding]; other site 1155071001993 B3/4 domain; Region: B3_4; pfam03483 1155071001994 tRNA synthetase B5 domain; Region: B5; smart00874 1155071001995 Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA, PheRS is an...; Region: PheRS_beta_core; cd00769 1155071001996 dimer interface [polypeptide binding]; other site 1155071001997 motif 1; other site 1155071001998 motif 3; other site 1155071001999 motif 2; other site 1155071002000 Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; pfam03147 1155071002001 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1155071002002 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1155071002003 non-specific DNA binding site [nucleotide binding]; other site 1155071002004 salt bridge; other site 1155071002005 sequence-specific DNA binding site [nucleotide binding]; other site 1155071002006 transcriptional activator, Rgg/GadR/MutR family, C-terminal domain; Region: RGG_Cterm; TIGR01716 1155071002007 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1155071002008 putative heme d1 biosynthesis radical SAM protein NirJ2; Region: rSAM_NirJ2; TIGR04055 1155071002009 FeS/SAM binding site; other site 1155071002010 radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085 1155071002011 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 1155071002012 putative efflux protein, MATE family; Region: matE; TIGR00797 1155071002013 Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; smart00896 1155071002014 Sugar efflux transporter for intercellular exchange; Region: MtN3_slv; pfam03083 1155071002015 ATP-dependent nuclease subunit B; Region: rexB_recomb; TIGR02774 1155071002016 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 1155071002017 helicase-exonuclease AddAB, AddA subunit, Firmicutes type; Region: addA_Gpos; TIGR02785 1155071002018 Family description; Region: UvrD_C_2; pfam13538 1155071002019 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 1155071002020 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 1155071002021 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; pfam08220 1155071002022 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 1155071002023 galactose-6-phosphate isomerase subunit LacA; Reviewed; Region: PRK08621 1155071002024 galactose-6-phosphate isomerase subunit LacB; Reviewed; Region: PRK08622 1155071002025 1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164 1155071002026 tagatose-6-phosphate kinase; Region: lacC; TIGR01231 1155071002027 putative substrate binding site [chemical binding]; other site 1155071002028 putative ATP binding site [chemical binding]; other site 1155071002029 tagatose 1,6-diphosphate aldolase; Reviewed; Region: PRK12399 1155071002030 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 1155071002031 active site 1155071002032 phosphorylation site [posttranslational modification] 1155071002033 Phosphotransferase system, galactitol-specific IIB component [Carbohydrate transport and metabolism]; Region: SgaB; COG3414 1155071002034 active site 1155071002035 P-loop; other site 1155071002036 phosphorylation site [posttranslational modification] 1155071002037 Phosphotransferase system, galactitol-specific IIC component [Carbohydrate transport and metabolism]; Region: GatC; COG3775 1155071002038 PTS system sugar-specific permease component; Region: EIIC-GAT; pfam03611 1155071002039 PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_lac; cd00215 1155071002040 active site 1155071002041 methionine cluster; other site 1155071002042 phosphorylation site [posttranslational modification] 1155071002043 metal binding site [ion binding]; metal-binding site 1155071002044 phosphotransferase system, lactose specific, IIC component; Region: lac_pts_IIC; TIGR00394 1155071002045 Phosphotransferase system, EIIC; Region: PTS_EIIC; pfam02378 1155071002046 PTS_IIB: subunit IIB of enzyme II (EII) is the central energy-coupling domain of the phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In the multienzyme PTS complex, EII is a carbohydrate-specific permease consisting of two cytoplasmic...; Region: PTS_IIB; cl10014 1155071002047 active site 1155071002048 P-loop; other site 1155071002049 phosphorylation site [posttranslational modification] 1155071002050 6-phospho-beta-galactosidase; Provisional; Region: PRK13511 1155071002051 beta-galactosidase; Region: BGL; TIGR03356 1155071002052 Aldose 1-epimerase, similar to Lactococcus lactis lacX; Region: Aldose_epim_lacX; cd09024 1155071002053 active site 1155071002054 catalytic residues [active] 1155071002055 Protein of unknown function (DUF3884); Region: DUF3884; pfam13024 1155071002056 CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311 1155071002057 substrate binding site [chemical binding]; other site 1155071002058 THF binding site; other site 1155071002059 zinc-binding site [ion binding]; other site 1155071002060 hypothetical protein; Provisional; Region: PRK07329 1155071002061 Polymerase and Histidinol Phosphatase domain; Region: PHP; cl17102 1155071002062 active site 1155071002063 GTPase subunit of restriction endonuclease [Defense mechanisms]; Region: McrB; COG1401 1155071002064 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1155071002065 Walker A motif; other site 1155071002066 ATP binding site [chemical binding]; other site 1155071002067 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 1155071002068 McrBC 5-methylcytosine restriction system component; Region: McrBC; cl01737 1155071002069 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 1155071002070 Predicted acetyltransferase [General function prediction only]; Region: COG3981 1155071002071 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1155071002072 Protein of unknown function (DUF3042); Region: DUF3042; pfam11240 1155071002073 tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091 1155071002074 tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324 1155071002075 GTP-binding protein HflX; Region: GTP_HflX; TIGR03156 1155071002076 GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167 1155071002077 HflX GTPase family; Region: HflX; cd01878 1155071002078 G1 box; other site 1155071002079 GTP/Mg2+ binding site [chemical binding]; other site 1155071002080 Switch I region; other site 1155071002081 G2 box; other site 1155071002082 G3 box; other site 1155071002083 Switch II region; other site 1155071002084 G4 box; other site 1155071002085 G5 box; other site 1155071002086 Galactose-1-phosphate uridyl transferase, N-terminal domain; Region: GalP_UDP_transf; pfam01087 1155071002087 ribonuclease Z; Region: RNase_Z; TIGR02651 1155071002088 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 1155071002089 classical (c) SDRs; Region: SDR_c; cd05233 1155071002090 NAD(P) binding site [chemical binding]; other site 1155071002091 active site 1155071002092 single-stranded-DNA-specific exonuclease RecJ; Region: recJ; TIGR00644 1155071002093 DHH family; Region: DHH; pfam01368 1155071002094 Single-strand DNA-specific exonuclease, C terminal domain; Region: ssDNA-exonuc_C; pfam10141 1155071002095 Predicted transcriptional regulator [Transcription]; Region: COG2378 1155071002096 HTH domain; Region: HTH_11; pfam08279 1155071002097 WYL domain; Region: WYL; pfam13280 1155071002098 GyrI-like small molecule binding domain; Region: GyrI-like; cl01368 1155071002099 disrupted protein; putative pseudogene 1155071002100 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1155071002101 active site 1155071002102 Homoserine O-succinyltransferase; Region: HTS; pfam04204 1155071002103 Type 1 glutamine amidotransferase (GATase1)-like domain found in homoserine trans-succinylase (HTS); Region: GATase1_HTS; cd03131 1155071002104 proposed active site lysine [active] 1155071002105 conserved cys residue [active] 1155071002106 Putative primosome component and related proteins [DNA replication, recombination, and repair]; Region: DnaD; COG3935 1155071002107 Replication initiation and membrane attachment; Region: DnaB_2; pfam07261 1155071002108 Predicted SAM-dependent methyltransferase [General function prediction only]; Region: COG2384 1155071002109 Family of unknown function (DUF633); Region: DUF633; pfam04816 1155071002110 Uncharacterized conserved protein [Function unknown]; Region: COG0327 1155071002111 NIF3 (NGG1p interacting factor 3); Region: NIF3; pfam01784 1155071002112 G1P_TT_short is the short form of glucose-1-phosphate thymidylyltransferase; Region: G1P_TT_short; cd02538 1155071002113 glucose-1-phosphate thymidylyltransferase, short form; Region: rmlA; TIGR01207 1155071002114 substrate binding site; other site 1155071002115 tetramer interface; other site 1155071002116 dTDP-4-dehydrorhamnose 3,5-epimerase and related enzymes [Cell envelope biogenesis, outer membrane]; Region: RfbC; COG1898 1155071002117 dTDP-D-glucose 4,6-dehydratase [Cell envelope biogenesis, outer membrane]; Region: RfbB; COG1088 1155071002118 dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246 1155071002119 NAD binding site [chemical binding]; other site 1155071002120 substrate binding site [chemical binding]; other site 1155071002121 homodimer interface [polypeptide binding]; other site 1155071002122 active site 1155071002123 MutT homolog-1 (MTH1) is a member of the Nudix hydrolase superfamily. MTH1, the mammalian counterpart of MutT, hydrolyzes oxidized purine nucleoside triphosphates, such as 8-oxo-dGTP and 2-hydroxy-ATP, to monophosphates, thereby preventing the...; Region: MTH1; cd03427 1155071002124 putative active site [active] 1155071002125 nucleotide binding site [chemical binding]; other site 1155071002126 nudix motif; other site 1155071002127 putative metal binding site [ion binding]; other site 1155071002128 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 1155071002129 Domain of unknown function DUF20; Region: UPF0118; pfam01594 1155071002130 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1155071002131 binding surface 1155071002132 TPR motif; other site 1155071002133 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1155071002134 binding surface 1155071002135 TPR motif; other site 1155071002136 acetolactate synthase; Reviewed; Region: PRK08617 1155071002137 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 1155071002138 PYR/PP interface [polypeptide binding]; other site 1155071002139 dimer interface [polypeptide binding]; other site 1155071002140 TPP binding site [chemical binding]; other site 1155071002141 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 1155071002142 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629 1155071002143 TPP-binding site [chemical binding]; other site 1155071002144 Alpha-acetolactate decarboxylase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: AlsD; COG3527 1155071002145 Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113 1155071002146 Spore germination protein; Region: Spore_permease; cl17796 1155071002147 Fibronectin-binding protein A N-terminus (FbpA); Region: FbpA; pfam05833 1155071002148 Domain of unknown function (DUF814); Region: DUF814; pfam05670 1155071002149 Type I periplasmic ligand-binding domain of uncharacterized ABC-type transport systems that are predicted to be involved in the uptake of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_uncharacterized_transporter; cd06325 1155071002150 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 1155071002151 zinc binding site [ion binding]; other site 1155071002152 putative ligand binding site [chemical binding]; other site 1155071002153 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 1155071002154 Transmembrane subunit (TM) of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which are involved in the uptake of branched-chain amino acids (AAs), as well as TMs of transporters involved in the uptake of...; Region: TM_PBP1_branched-chain-AA_like; cd06574 1155071002155 TM-ABC transporter signature motif; other site 1155071002156 ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: PhnK; COG1101 1155071002157 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1155071002158 Walker A/P-loop; other site 1155071002159 ATP binding site [chemical binding]; other site 1155071002160 Q-loop/lid; other site 1155071002161 ABC transporter signature motif; other site 1155071002162 Walker B; other site 1155071002163 D-loop; other site 1155071002164 H-loop/switch region; other site 1155071002165 mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595 1155071002166 Metallo-beta-lactamase superfamily; Region: Lactamase_B; pfam00753 1155071002167 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 1155071002168 Zinc finger domain containing protein (CHY type) [Function unknown]; Region: COG4357 1155071002169 CHY zinc finger; Region: zf-CHY; pfam05495 1155071002170 S-formylglutathione hydrolase; Region: PLN02442 1155071002171 Predicted esterase [General function prediction only]; Region: COG0627 1155071002172 Protein of unknown function (DUF1307); Region: DUF1307; pfam06998 1155071002173 Zinc-dependent metalloprotease, MMP_like subfamily. This group contains matrix metalloproteinases (MMPs), serralysins, and the astacin_like family of proteases; Region: ZnMc_MMP_like; cd04268 1155071002174 active site 1155071002175 UDP-N-acetylglucosamine 2-epimerase [Cell envelope biogenesis, outer membrane]; Region: WecB; COG0381 1155071002176 Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786 1155071002177 active site 1155071002178 homodimer interface [polypeptide binding]; other site 1155071002179 Protein gp23 (Bacteriophage A118); Region: Phage_Gp23; pfam10669 1155071002180 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 1155071002181 CESA_like is the cellulose synthase superfamily; Region: CESA_like; cd06423 1155071002182 DXD motif; other site 1155071002183 Glycosyl hydrolases family 8; Region: Glyco_hydro_8; cl01351 1155071002184 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 1155071002185 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1155071002186 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1155071002187 ABC transporter; Region: ABC_tran_2; pfam12848 1155071002188 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1155071002189 ABC transporter; Region: ABC_tran_2; pfam12848 1155071002190 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyric Acid Synthase (CobQ); Region: GATase1_CobQ; cd01750 1155071002191 catalytic triad [active] 1155071002192 UDP-N-acetylmuramyl tripeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurE; COG0769 1155071002193 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 1155071002194 Domain of unknown function (DUF1727); Region: DUF1727; pfam08353 1155071002195 Uncharacterized conserved protein [Function unknown]; Region: COG1624 1155071002196 DisA bacterial checkpoint controller nucleotide-binding; Region: DisA_N; pfam02457 1155071002197 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4856 1155071002198 YbbR-like protein; Region: YbbR; pfam07949 1155071002199 YbbR-like protein; Region: YbbR; pfam07949 1155071002200 phosphoglucosamine mutase; Provisional; Region: glmM; PRK14316 1155071002201 GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802 1155071002202 active site 1155071002203 substrate binding site [chemical binding]; other site 1155071002204 metal binding site [ion binding]; metal-binding site 1155071002205 ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346 1155071002206 Clp amino terminal domain; Region: Clp_N; pfam02861 1155071002207 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1155071002208 Walker A motif; other site 1155071002209 ATP binding site [chemical binding]; other site 1155071002210 Walker B motif; other site 1155071002211 arginine finger; other site 1155071002212 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1155071002213 Walker A motif; other site 1155071002214 ATP binding site [chemical binding]; other site 1155071002215 Walker B motif; other site 1155071002216 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 1155071002217 dihydrolipoamide dehydrogenase; Region: lipoamide_DH; TIGR01350 1155071002218 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1155071002219 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 1155071002220 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, alpha subunit [Energy production and conversion]; Region: AcoA; COG1071 1155071002221 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 1155071002222 tetramer interface [polypeptide binding]; other site 1155071002223 TPP-binding site [chemical binding]; other site 1155071002224 heterodimer interface [polypeptide binding]; other site 1155071002225 phosphorylation loop region [posttranslational modification] 1155071002226 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 1155071002227 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 1155071002228 alpha subunit interface [polypeptide binding]; other site 1155071002229 TPP binding site [chemical binding]; other site 1155071002230 heterodimer interface [polypeptide binding]; other site 1155071002231 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 1155071002232 branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856 1155071002233 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 1155071002234 E3 interaction surface; other site 1155071002235 lipoyl attachment site [posttranslational modification]; other site 1155071002236 e3 binding domain; Region: E3_binding; pfam02817 1155071002237 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 1155071002238 Putative NADPH-quinone reductase (modulator of drug activity B) [General function prediction only]; Region: MdaB; COG2249 1155071002239 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 1155071002240 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1155071002241 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1155071002242 WHG domain; Region: WHG; pfam13305 1155071002243 coproporphyrinogen III oxidase; Provisional; Region: PRK08599 1155071002244 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1155071002245 FeS/SAM binding site; other site 1155071002246 HemN C-terminal domain; Region: HemN_C; pfam06969 1155071002247 Acyl-ACP thioesterase; Region: Acyl-ACP_TE; pfam01643 1155071002248 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 1155071002249 active site 1155071002250 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 1155071002251 active site 2 [active] 1155071002252 Hydrolase of X-linked nucleoside diphosphate N terminal; Region: Nudix_N; pfam12535 1155071002253 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_14; cd04672 1155071002254 nudix motif; other site 1155071002255 HAD-superfamily subfamily IIA hydrolase, TIGR01457; Region: HAD-SF-IIA-hyp2 1155071002256 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1155071002257 active site 1155071002258 motif I; other site 1155071002259 motif II; other site 1155071002260 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1155071002261 Protein of unknown function (DUF1461); Region: DUF1461; pfam07314 1155071002262 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 1155071002263 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 1155071002264 Walker A/P-loop; other site 1155071002265 ATP binding site [chemical binding]; other site 1155071002266 Q-loop/lid; other site 1155071002267 ABC transporter signature motif; other site 1155071002268 Walker B; other site 1155071002269 D-loop; other site 1155071002270 H-loop/switch region; other site 1155071002271 ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]; Region: LolE; COG4591 1155071002272 FtsX-like permease family; Region: FtsX; pfam02687 1155071002273 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1155071002274 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1155071002275 hypothetical protein; Validated; Region: PRK07121 1155071002276 Predicted oxidoreductase [General function prediction only]; Region: COG3573 1155071002277 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1155071002278 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1155071002279 Predicted flavoprotein [General function prediction only]; Region: COG0431 1155071002280 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 1155071002281 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cl00083 1155071002282 CRISPR/Cas system-associated protein Cas9; Region: Csn1; cd09643 1155071002283 CRISPR/Cas system-associated protein Cas1; Region: Cas1_II; cd09720 1155071002284 CRISPR/Cas system-associated protein Cas2; Region: Cas2_I_II_III; cd09638 1155071002285 CRISPR/Cas system-associated protein Csn2; Region: Csn2; cd09758 1155071002286 CRISPR type II-A/NMEMI-associated protein Csn2; Region: cas_Csn2; TIGR01866 1155071002287 tetramer interface [polypeptide binding]; other site 1155071002288 putative DNA binding site [nucleotide binding]; other site 1155071002289 Ca binding site [ion binding]; other site 1155071002290 Ca binding site [ion binding]; other site 1155071002291 YcfA-like protein; Region: YcfA; pfam07927 1155071002292 Uncharacterized protein family (UPF0150); Region: UPF0150; pfam03681 1155071002293 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1155071002294 non-specific DNA binding site [nucleotide binding]; other site 1155071002295 salt bridge; other site 1155071002296 sequence-specific DNA binding site [nucleotide binding]; other site 1155071002297 Predicted transcriptional regulator [Transcription]; Region: COG2932 1155071002298 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 1155071002299 Catalytic site [active] 1155071002300 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1155071002301 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1155071002302 non-specific DNA binding site [nucleotide binding]; other site 1155071002303 salt bridge; other site 1155071002304 sequence-specific DNA binding site [nucleotide binding]; other site 1155071002305 Glucan-binding protein C; Region: GbpC; pfam08363 1155071002306 GTP-binding protein LepA; Provisional; Region: PRK05433 1155071002307 LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890 1155071002308 G1 box; other site 1155071002309 putative GEF interaction site [polypeptide binding]; other site 1155071002310 GTP/Mg2+ binding site [chemical binding]; other site 1155071002311 Switch I region; other site 1155071002312 G2 box; other site 1155071002313 G3 box; other site 1155071002314 Switch II region; other site 1155071002315 G4 box; other site 1155071002316 G5 box; other site 1155071002317 lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699 1155071002318 lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane. LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709 1155071002319 GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421 1155071002320 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1155071002321 disrupted acetyltransferase; putative pseudogene 1155071002322 Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and...; Region: PEPCK_HprK; cl00270 1155071002323 active site 1155071002324 metal-binding site [ion binding] 1155071002325 active site 1155071002326 nucleotide-binding site [chemical binding]; other site 1155071002327 nucleotide-binding site [chemical binding]; other site 1155071002328 DEAD-like helicases superfamily; Region: DEXDc; smart00487 1155071002329 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 1155071002330 ATP binding site [chemical binding]; other site 1155071002331 putative Mg++ binding site [ion binding]; other site 1155071002332 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1155071002333 nucleotide binding region [chemical binding]; other site 1155071002334 ATP-binding site [chemical binding]; other site 1155071002335 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 1155071002336 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232 1155071002337 LabA_like proteins; Region: LabA_like; cd06167 1155071002338 putative metal binding site [ion binding]; other site 1155071002339 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 1155071002340 Uridine kinase [Nucleotide transport and metabolism]; Region: Udk; COG0572 1155071002341 Uridine monophosphate kinase (UMPK, EC 2.7.1.48), also known as uridine kinase or uridine-cytidine kinase (UCK), catalyzes the reversible phosphoryl transfer from ATP to uridine or cytidine to yield UMP or CMP. In the primidine nucleotide-salvage pathway; Region: UMPK; cd02023 1155071002342 Sugar specificity; other site 1155071002343 Pyrimidine base specificity; other site 1155071002344 ATP-binding site [chemical binding]; other site 1155071002345 2-isopropylmalate synthase; Validated; Region: PRK00915 1155071002346 2-isopropylmalate synthase (IPMS), N-terminal catalytic TIM barrel domain; Region: DRE_TIM_IPMS; cd07940 1155071002347 active site 1155071002348 catalytic residues [active] 1155071002349 metal binding site [ion binding]; metal-binding site 1155071002350 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; pfam08502 1155071002351 3-isopropylmalate dehydrogenase; Provisional; Region: PRK00772 1155071002352 tartrate dehydrogenase; Region: TTC; TIGR02089 1155071002353 3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402 1155071002354 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583 1155071002355 substrate binding site [chemical binding]; other site 1155071002356 ligand binding site [chemical binding]; other site 1155071002357 isopropylmalate isomerase small subunit; Provisional; Region: leuD; PRK01641 1155071002358 Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577 1155071002359 substrate binding site [chemical binding]; other site 1155071002360 Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily; Region: PI-PLCc_GDPD_SF; cl14615 1155071002361 Telomere recombination; Region: Sua5_yciO_yrdC; cl00305 1155071002362 Uncharacterized protein family (UPF0157); Region: UPF0157; pfam04229 1155071002363 Protein of unknown function (DUF2568); Region: DUF2568; pfam10823 1155071002364 Methyltransferase domain; Region: Methyltransf_31; pfam13847 1155071002365 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1155071002366 S-adenosylmethionine binding site [chemical binding]; other site 1155071002367 Type 1 glutamine amidotransferase (GATase1)-like domain found in peptidase E_like proteins; Region: GAT1_Peptidase_E_like; cd03129 1155071002368 catalytic triad [active] 1155071002369 active site nucleophile [active] 1155071002370 epoxyqueuosine reductase; Region: TIGR00276 1155071002371 Domain of unknown function (DUF1730); Region: DUF1730; pfam08331 1155071002372 PCRF domain; Region: PCRF; pfam03462 1155071002373 Protein chain release factor B [Translation, ribosomal structure and biogenesis]; Region: PrfB; COG1186 1155071002374 RF-1 domain; Region: RF-1; pfam00472 1155071002375 Predicted ATPase involved in cell division [Cell division and chromosome partitioning]; Region: FtsE; COG2884 1155071002376 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1155071002377 Walker A/P-loop; other site 1155071002378 ATP binding site [chemical binding]; other site 1155071002379 Q-loop/lid; other site 1155071002380 ABC transporter signature motif; other site 1155071002381 Walker B; other site 1155071002382 D-loop; other site 1155071002383 H-loop/switch region; other site 1155071002384 Cell division protein [Cell division and chromosome partitioning]; Region: FtsX; COG2177 1155071002385 cell division ABC transporter subunit FtsX; Provisional; Region: ftsX; PRK11026 1155071002386 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 1155071002387 acetoin reductase; Validated; Region: PRK08643 1155071002388 meso-2,3-butanediol dehydrogenase-like, classical (c) SDRs; Region: meso-BDH-like_SDR_c; cd05366 1155071002389 NAD binding site [chemical binding]; other site 1155071002390 homotetramer interface [polypeptide binding]; other site 1155071002391 homodimer interface [polypeptide binding]; other site 1155071002392 active site 1155071002393 substrate binding site [chemical binding]; other site 1155071002394 ATP-grasp domain; Region: ATP-grasp_4; pfam13535 1155071002395 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4947 1155071002396 Putative esterase; Region: Esterase; pfam00756 1155071002397 cytochrome c biogenesis protein CcmA; Provisional; Region: PRK13540 1155071002398 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cd00267 1155071002399 Walker A/P-loop; other site 1155071002400 ATP binding site [chemical binding]; other site 1155071002401 Q-loop/lid; other site 1155071002402 ABC transporter signature motif; other site 1155071002403 Walker B; other site 1155071002404 D-loop; other site 1155071002405 H-loop/switch region; other site 1155071002406 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819 1155071002407 bifunctional ATP-dependent DNA helicase/DNA polymerase III subunit epsilon; Validated; Region: PRK07246 1155071002408 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 1155071002409 active site 1155071002410 catalytic site [active] 1155071002411 substrate binding site [chemical binding]; other site 1155071002412 DEAD/DEAH box helicase; Region: DEAD; pfam00270 1155071002413 ATP binding site [chemical binding]; other site 1155071002414 Helicase C-terminal domain; Region: Helicase_C_2; pfam13307 1155071002415 aspartate aminotransferase; Provisional; Region: PRK05764 1155071002416 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1155071002417 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1155071002418 homodimer interface [polypeptide binding]; other site 1155071002419 catalytic residue [active] 1155071002420 asparaginyl-tRNA synthetase; Validated; Region: asnC; PRK03932 1155071002421 AsnRS_cyto_like_N: N-terminal, anticodon recognition domain of the type found in human and Saccharomyces cerevisiae cytoplasmic asparaginyl-tRNA synthetase (AsnRS), in Brugia malayai AsnRs and, in various putative bacterial AsnRSs. This domain is a...; Region: AsnRS_cyto_like_N; cd04323 1155071002422 putative dimer interface [polypeptide binding]; other site 1155071002423 putative anticodon binding site; other site 1155071002424 Asx tRNA synthetase (AspRS/AsnRS) class II core domain. Assignment to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs in the core domain. This family includes AsnRS as well as...; Region: AsxRS_core; cd00776 1155071002425 homodimer interface [polypeptide binding]; other site 1155071002426 motif 1; other site 1155071002427 motif 2; other site 1155071002428 active site 1155071002429 motif 3; other site 1155071002430 Glycerol dehydrogenase and related enzymes [Energy production and conversion]; Region: GldA; COG0371 1155071002431 Glycerol dehydrogenase-like; Region: GlyDH-like2; cd08171 1155071002432 putative active site [active] 1155071002433 metal binding site [ion binding]; metal-binding site 1155071002434 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 1155071002435 homotrimer interaction site [polypeptide binding]; other site 1155071002436 putative active site [active] 1155071002437 Protein of unknown function (DUF1003); Region: DUF1003; pfam06210 1155071002438 glmZ(sRNA)-inactivating NTPase; Provisional; Region: PRK05416 1155071002439 conserved hypothetical protein, cofD-related; Region: CofD_related; TIGR01826 1155071002440 Family of CofD-like proteins and proteins related to YvcK; Region: CofD_YvcK; cd07044 1155071002441 dimer interface [polypeptide binding]; other site 1155071002442 phosphate binding site [ion binding]; other site 1155071002443 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1481 1155071002444 Sporulation Regulator WhiA N terminal; Region: WhiA_N; pfam10298 1155071002445 Peptidase family C69; Region: Peptidase_C69; pfam03577 1155071002446 Metal binding protein AcdA. These proteins have been shown to function in the ABC uptake of Zn2+ and Mn2+ and in competence for genetic transformation and adhesion. The AcdA proteins belong to the TroA superfamily of helical backbone metal receptor...; Region: AdcA; cd01017 1155071002447 Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297 1155071002448 metal binding site [ion binding]; metal-binding site 1155071002449 YodA lipocalin-like domain; Region: YodA; cl01365 1155071002450 Methyltransferase domain; Region: Methyltransf_31; pfam13847 1155071002451 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1155071002452 S-adenosylmethionine binding site [chemical binding]; other site 1155071002453 Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1917 1155071002454 Cupin domain; Region: Cupin_2; cl17218 1155071002455 50S ribosomal protein L31 type B; Reviewed; Region: rpmE2; PRK01678 1155071002456 Exopolyphosphatase-related proteins [General function prediction only]; Region: COG0618 1155071002457 DHH family; Region: DHH; pfam01368 1155071002458 DHHA1 domain; Region: DHHA1; pfam02272 1155071002459 putative S-transferase; Provisional; Region: PRK11752 1155071002460 GST_N family, Ure2p-like subfamily; composed of the Saccharomyces cerevisiae Ure2p and related GSTs. Ure2p is a regulator for nitrogen catabolism in yeast. It represses the expression of several gene products involved in the use of poor nitrogen sources...; Region: GST_N_Ure2p_like; cd03048 1155071002461 C-terminal domain interface [polypeptide binding]; other site 1155071002462 GSH binding site (G-site) [chemical binding]; other site 1155071002463 dimer interface [polypeptide binding]; other site 1155071002464 C-terminal, alpha helical domain of Escherichia coli Yghu Glutathione S-transferases and related uncharacterized proteins; Region: GST_C_YghU_like; cd10292 1155071002465 dimer interface [polypeptide binding]; other site 1155071002466 N-terminal domain interface [polypeptide binding]; other site 1155071002467 active site 1155071002468 adenosine deaminase; Provisional; Region: PRK09358 1155071002469 active site 1155071002470 flavodoxin; Validated; Region: PRK07308 1155071002471 cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814; cl03223 1155071002472 FeS assembly protein SufB; Region: sufB; TIGR01980 1155071002473 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 1155071002474 hypothetical protein; Provisional; Region: PRK07248 1155071002475 Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038 1155071002476 ClC sycA-like chloride channel proteins. This ClC family presents in bacteria, where it facilitates acid resistance in acidic soil. Mutation of this gene (sycA) in Rhizobium tropici CIAT899 causes serious deficiencies in nodule development, nodulation...; Region: ClC_sycA_like; cd03682 1155071002477 putative Cl- selectivity filter; other site 1155071002478 putative pore gating glutamate residue; other site 1155071002479 Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038 1155071002480 ClC sycA-like chloride channel proteins. This ClC family presents in bacteria, where it facilitates acid resistance in acidic soil. Mutation of this gene (sycA) in Rhizobium tropici CIAT899 causes serious deficiencies in nodule development, nodulation...; Region: ClC_sycA_like; cd03682 1155071002481 putative Cl- selectivity filter; other site 1155071002482 putative pore gating glutamate residue; other site 1155071002483 L19_leader; Ribosomal protein L19 leader 1155071002484 50S ribosomal protein L19; Provisional; Region: rplS; PRK05338 1155071002485 Helix-Turn-Helix DNA binding domain of GlnR-like transcription regulators; Region: HTH_GlnR-like; cd01105 1155071002486 DNA binding residues [nucleotide binding] 1155071002487 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 1155071002488 putative dimer interface [polypeptide binding]; other site 1155071002489 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1155071002490 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1155071002491 putative substrate translocation pore; other site 1155071002492 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1155071002493 NADH(P)-binding; Region: NAD_binding_10; pfam13460 1155071002494 NAD(P) binding site [chemical binding]; other site 1155071002495 active site 1155071002496 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1155071002497 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1155071002498 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1155071002499 Bacterial cell division membrane protein [Cell division and chromosome partitioning]; Region: FtsW; COG0772 1155071002500 Haloacid dehalogenase-like hydrolase; Region: HAD_2; pfam13419 1155071002501 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1155071002502 motif II; other site 1155071002503 DNA gyrase subunit B; Validated; Region: gyrB; PRK05644 1155071002504 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1155071002505 Mg2+ binding site [ion binding]; other site 1155071002506 G-X-G motif; other site 1155071002507 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 1155071002508 anchoring element; other site 1155071002509 dimer interface [polypeptide binding]; other site 1155071002510 ATP binding site [chemical binding]; other site 1155071002511 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 1155071002512 active site 1155071002513 putative metal-binding site [ion binding]; other site 1155071002514 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 1155071002515 septation ring formation regulator EzrA; Provisional; Region: PRK04778 1155071002516 Histidinol-phosphate/aromatic aminotransferase and cobyric acid decarboxylase [Amino acid transport and metabolism]; Region: HisC; COG0079 1155071002517 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1155071002518 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1155071002519 homodimer interface [polypeptide binding]; other site 1155071002520 catalytic residue [active] 1155071002521 ATP phosphoribosyltransferase, regulatory subunit; Region: hisZ_biosyn_reg; TIGR00443 1155071002522 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 1155071002523 dimer interface [polypeptide binding]; other site 1155071002524 motif 1; other site 1155071002525 active site 1155071002526 motif 2; other site 1155071002527 motif 3; other site 1155071002528 ATP phosphoribosyltransferase catalytic subunit; Reviewed; Region: hisG; PRK01686 1155071002529 ATP phosphoribosyltransferase [Amino acid transport and metabolism]; Region: HisG; COG0040 1155071002530 Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572 1155071002531 histidinol dehydrogenase; Region: hisD; TIGR00069 1155071002532 NAD binding site [chemical binding]; other site 1155071002533 dimerization interface [polypeptide binding]; other site 1155071002534 product binding site; other site 1155071002535 substrate binding site [chemical binding]; other site 1155071002536 zinc binding site [ion binding]; other site 1155071002537 catalytic residues [active] 1155071002538 phosphoserine phosphatase SerB; Region: serB; TIGR00338 1155071002539 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1155071002540 motif II; other site 1155071002541 Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cd07914 1155071002542 putative active site pocket [active] 1155071002543 4-fold oligomerization interface [polypeptide binding]; other site 1155071002544 metal binding residues [ion binding]; metal-binding site 1155071002545 3-fold/trimer interface [polypeptide binding]; other site 1155071002546 Protein of unknown function (DUF2568); Region: DUF2568; pfam10823 1155071002547 imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13141 1155071002548 Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748 1155071002549 putative active site [active] 1155071002550 oxyanion strand; other site 1155071002551 catalytic triad [active] 1155071002552 HisA. Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1...; Region: HisA; cd04732 1155071002553 phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; Region: TIGR00007 1155071002554 catalytic residues [active] 1155071002555 The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731 1155071002556 Histidine biosynthesis protein; Region: His_biosynth; pfam00977 1155071002557 substrate binding site [chemical binding]; other site 1155071002558 glutamase interaction surface [polypeptide binding]; other site 1155071002559 phosphoribosyl-AMP cyclohydrolase; Reviewed; Region: hisI; PRK00051 1155071002560 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in Escherichia coli phosphoribosyl-ATP pyrophosphohydrolase (HisIE or PRATP-PH) and its homologs; Region: NTP-PPase_HisIE_like; cd11534 1155071002561 metal binding site [ion binding]; metal-binding site 1155071002562 DivIVA protein; Region: DivIVA; pfam05103 1155071002563 DivIVA domain; Region: DivI1A_domain; TIGR03544 1155071002564 PemK-like protein; Region: PemK; pfam02452 1155071002565 Eco57I restriction-modification methylase; Region: Eco57I; pfam07669 1155071002566 TaqI-like C-terminal specificity domain; Region: TaqI_C; pfam12950 1155071002567 TaqI-like C-terminal specificity domain; Region: TaqI_C; pfam12950 1155071002568 multiple promoter invertase; Provisional; Region: mpi; PRK13413 1155071002569 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768 1155071002570 catalytic residues [active] 1155071002571 catalytic nucleophile [active] 1155071002572 Presynaptic Site I dimer interface [polypeptide binding]; other site 1155071002573 Synaptic Antiparallel dimer interface [polypeptide binding]; other site 1155071002574 Synaptic Flat tetramer interface [polypeptide binding]; other site 1155071002575 Synaptic Site I dimer interface [polypeptide binding]; other site 1155071002576 DNA binding site [nucleotide binding] 1155071002577 Homeodomain-like domain; Region: HTH_23; pfam13384 1155071002578 N-terminal putative catalytic domain of uncharacterized HKD family nucleases fused to putative helicases from the Snf2-like family; Region: PLDc_N_Snf2_like; cd09178 1155071002579 PLD-like domain; Region: PLDc_2; pfam13091 1155071002580 putative homodimer interface [polypeptide binding]; other site 1155071002581 putative active site [active] 1155071002582 catalytic site [active] 1155071002583 DEAD-like helicases superfamily; Region: DEXDc; smart00487 1155071002584 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1155071002585 ATP binding site [chemical binding]; other site 1155071002586 putative Mg++ binding site [ion binding]; other site 1155071002587 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1155071002588 nucleotide binding region [chemical binding]; other site 1155071002589 ATP-binding site [chemical binding]; other site 1155071002590 Domain of unknown function (DUF3387); Region: DUF3387; pfam11867 1155071002591 Plasmid maintenance system killer protein; Region: Plasmid_killer; cl01422 1155071002592 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1155071002593 non-specific DNA binding site [nucleotide binding]; other site 1155071002594 salt bridge; other site 1155071002595 sequence-specific DNA binding site [nucleotide binding]; other site 1155071002596 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 1155071002597 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1155071002598 motif II; other site 1155071002599 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1155071002600 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 1155071002601 Coenzyme A binding pocket [chemical binding]; other site 1155071002602 Glycerate kinase [Carbohydrate transport and metabolism]; Region: COG1929 1155071002603 Protein of unknown function (DUF1694); Region: DUF1694; pfam07997 1155071002604 Protein of unknown function (DUF2681); Region: DUF2681; pfam10883 1155071002605 Domain of unknown function (DUF4352); Region: DUF4352; pfam11611 1155071002606 enolase; Provisional; Region: eno; PRK00077 1155071002607 Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313 1155071002608 dimer interface [polypeptide binding]; other site 1155071002609 metal binding site [ion binding]; metal-binding site 1155071002610 substrate binding pocket [chemical binding]; other site 1155071002611 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1155071002612 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1155071002613 potential frameshift: common BLAST hit: gi|288905122|ref|YP_003430344.1| HAD-superfamily hydrolase / phosphatase 1155071002614 HAD superfamily (subfamily IA) hydrolase, TIGR02254; Region: YjjG/YfnB 1155071002615 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1155071002616 motif II; other site 1155071002617 Bacterial low temperature requirement A protein (LtrA); Region: LtrA; cl01754 1155071002618 excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558 1155071002619 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 1155071002620 GIY-YIG motif/motif A; other site 1155071002621 active site 1155071002622 catalytic site [active] 1155071002623 putative DNA binding site [nucleotide binding]; other site 1155071002624 metal binding site [ion binding]; metal-binding site 1155071002625 UvrB/uvrC motif; Region: UVR; pfam02151 1155071002626 UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459 1155071002627 Nitroreductase-like family 1. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_1; cd02137 1155071002628 dimer interface [polypeptide binding]; other site 1155071002629 FMN binding site [chemical binding]; other site 1155071002630 dipeptidase PepV; Reviewed; Region: PRK07318 1155071002631 M20 Peptidase Xaa-His dipeptidase (PepV) degrades hydrophobic dipeptides; Region: M20_PepV; cd03888 1155071002632 active site 1155071002633 metal binding site [ion binding]; metal-binding site 1155071002634 Uncharacterized subfamily of Uracil-DNA glycosylases; Region: UDG_like_1; cd10033 1155071002635 putative uracil binding site [chemical binding]; other site 1155071002636 putative active site [active] 1155071002637 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1155071002638 dimerization interface [polypeptide binding]; other site 1155071002639 putative DNA binding site [nucleotide binding]; other site 1155071002640 putative Zn2+ binding site [ion binding]; other site 1155071002641 SnoaL-like domain; Region: SnoaL_2; pfam12680 1155071002642 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 1155071002643 tRNA modification GTPase TrmE; Reviewed; Region: trmE; PRK05291 1155071002644 GTP-binding protein TrmE N-terminus; Region: TrmE_N; pfam10396 1155071002645 trmE is a tRNA modification GTPase; Region: trmE; cd04164 1155071002646 G1 box; other site 1155071002647 GTP/Mg2+ binding site [chemical binding]; other site 1155071002648 Switch I region; other site 1155071002649 G2 box; other site 1155071002650 Switch II region; other site 1155071002651 G3 box; other site 1155071002652 G4 box; other site 1155071002653 G5 box; other site 1155071002654 Catalytic cysteine-containing C-terminus of GTPase, MnmE; Region: GTPase_Cys_C; pfam12631 1155071002655 RPI_A: Ribose 5-phosphate isomerase type A (RPI_A) subfamily; RPI catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate, the first step of the non-oxidative branch of the pentose phosphate pathway. This reaction leads to the...; Region: RPI_A; cd01398 1155071002656 tetramer (dimer of dimers) interface [polypeptide binding]; other site 1155071002657 active site 1155071002658 dimer interface [polypeptide binding]; other site 1155071002659 phosphopentomutase; Provisional; Region: PRK05362 1155071002660 Metalloenzyme superfamily; Region: Metalloenzyme; pfam01676 1155071002661 Protein of unknown function (DUF1697); Region: DUF1697; pfam08002 1155071002662 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1155071002663 PGAP1-like protein; Region: PGAP1; pfam07819 1155071002664 purine nucleoside phosphorylase; Provisional; Region: PRK08202 1155071002665 GMP synthase - Glutamine amidotransferase domain [Nucleotide transport and metabolism]; Region: GuaA; COG0518 1155071002666 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_1; cd01741 1155071002667 catalytic triad [active] 1155071002668 purine nucleoside phosphorylase; Reviewed; Region: deoD; PRK05819 1155071002669 Uridine phosphorylase [Nucleotide transport and metabolism]; Region: Udp; COG2820 1155071002670 CRISPR/Cas system-associated protein Csm6; Region: Csm6_III-A; cl09873 1155071002671 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1155071002672 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1155071002673 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 1155071002674 dimerization interface [polypeptide binding]; other site 1155071002675 dihydroorotate dehydrogenase electron transfer subunit; Reviewed; Region: PRK00054 1155071002676 FAD/NAD binding domain in the electron transfer subunit of dihydroorotate dehydrogenase. Dihydroorotate dehydrogenases (DHODs) catalyze the only redox reaction in pyrimidine de novo biosynthesis. They catalyze the oxidation of (S)-dihydroorotate to...; Region: DHOD_e_trans; cd06218 1155071002677 FAD binding pocket [chemical binding]; other site 1155071002678 FAD binding motif [chemical binding]; other site 1155071002679 phosphate binding motif [ion binding]; other site 1155071002680 beta-alpha-beta structure motif; other site 1155071002681 NAD binding pocket [chemical binding]; other site 1155071002682 Iron coordination center [ion binding]; other site 1155071002683 dihydroorotate dehydrogenase (subfamily 1) family protein; Region: pyrD_sub1_fam; TIGR01037 1155071002684 Dihydroorotate dehydrogenase (DHOD) class 1B FMN-binding domain. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine...; Region: DHOD_1B_like; cd04740 1155071002685 heterodimer interface [polypeptide binding]; other site 1155071002686 active site 1155071002687 FMN binding site [chemical binding]; other site 1155071002688 homodimer interface [polypeptide binding]; other site 1155071002689 substrate binding site [chemical binding]; other site 1155071002690 Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725 1155071002691 active site 1155071002692 dimer interface [polypeptide binding]; other site 1155071002693 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1155071002694 active site 1155071002695 PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in bacteria and archaea; Region: PEBP_bact_arch; cd00865 1155071002696 substrate binding site [chemical binding]; other site 1155071002697 Protein of unknown function (DUF419); Region: DUF419; pfam04237 1155071002698 amidase; Provisional; Region: PRK06529 1155071002699 Amidase; Region: Amidase; cl11426 1155071002700 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1155071002701 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 1155071002702 substrate binding pocket [chemical binding]; other site 1155071002703 membrane-bound complex binding site; other site 1155071002704 hinge residues; other site 1155071002705 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1155071002706 dimer interface [polypeptide binding]; other site 1155071002707 conserved gate region; other site 1155071002708 putative PBP binding loops; other site 1155071002709 ABC-ATPase subunit interface; other site 1155071002710 Family 1 of Uracil-DNA glycosylase (UDG) enzymes; Region: UDG_F1; cd10027 1155071002711 ligand binding site [chemical binding]; other site 1155071002712 active site 1155071002713 UGI interface [polypeptide binding]; other site 1155071002714 catalytic site [active] 1155071002715 dihydroorotase; Validated; Region: pyrC; PRK09357 1155071002716 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 1155071002717 Dihydroorotase (DHOase), subgroup IIa; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This subgroup also contains proteins that lack the active site, like unc-33, a C; Region: DHOase_IIa; cd01317 1155071002718 active site 1155071002719 Staphylococcus aureus SA0022 and related proteins, N-terminal metallophosphatase domain; Region: MPP_SA0022_N; cd07408 1155071002720 5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737 1155071002721 putative active site [active] 1155071002722 putative metal binding site [ion binding]; other site 1155071002723 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 1155071002724 putative glycerol-3-phosphate acyltransferase PlsY; Provisional; Region: PRK00220 1155071002725 DNA topoisomerase IV, B subunit, Gram-positive; Region: parE_Gpos; TIGR01058 1155071002726 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1155071002727 Mg2+ binding site [ion binding]; other site 1155071002728 G-X-G motif; other site 1155071002729 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 1155071002730 anchoring element; other site 1155071002731 dimer interface [polypeptide binding]; other site 1155071002732 ATP binding site [chemical binding]; other site 1155071002733 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 1155071002734 active site 1155071002735 putative metal-binding site [ion binding]; other site 1155071002736 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 1155071002737 RelA- and SpoT-like ppGpp Synthetases and Hydrolases, catalytic domain; Region: Rel-Spo_like; cl11966 1155071002738 metal binding triad [ion binding]; metal-binding site 1155071002739 DNA topoisomerase IV, A subunit, Gram-positive; Region: parC_Gpos; TIGR01061 1155071002740 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 1155071002741 CAP-like domain; other site 1155071002742 active site 1155071002743 primary dimer interface [polypeptide binding]; other site 1155071002744 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1155071002745 branched-chain amino acid aminotransferase; Provisional; Region: PRK13357 1155071002746 BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557 1155071002747 homodimer interface [polypeptide binding]; other site 1155071002748 substrate-cofactor binding pocket; other site 1155071002749 catalytic residue [active] 1155071002750 Protein of unknown function (DUF2969); Region: DUF2969; pfam11184 1155071002751 30S ribosomal protein S1; Reviewed; Region: rpsA; PRK06676 1155071002752 S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687 1155071002753 RNA binding site [nucleotide binding]; other site 1155071002754 S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465 1155071002755 RNA binding site [nucleotide binding]; other site 1155071002756 S1_RPS1_repeat_ec3: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec3; cd05688 1155071002757 RNA binding site [nucleotide binding]; other site 1155071002758 S1_RPS1_repeat_hs4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_hs4; cd05692 1155071002759 RNA binding site [nucleotide binding]; other site 1155071002760 Uncharacterized conserved protein [Function unknown]; Region: COG0398 1155071002761 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 1155071002762 Domain of Unknown Function with PDB structure (DUF3862); Region: DUF3862; pfam12978 1155071002763 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 1155071002764 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 1155071002765 Walker A/P-loop; other site 1155071002766 ATP binding site [chemical binding]; other site 1155071002767 Q-loop/lid; other site 1155071002768 ABC transporter signature motif; other site 1155071002769 Walker B; other site 1155071002770 D-loop; other site 1155071002771 H-loop/switch region; other site 1155071002772 Predicted transcriptional regulators [Transcription]; Region: COG1725 1155071002773 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1155071002774 DNA-binding site [nucleotide binding]; DNA binding site 1155071002775 DNA polymerase III DnaE; Reviewed; Region: dnaE; PRK07279 1155071002776 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III; Region: PHP_PolIIIA; cd07431 1155071002777 active site 1155071002778 PHP Thumb interface [polypeptide binding]; other site 1155071002779 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 1155071002780 generic binding surface II; other site 1155071002781 generic binding surface I; other site 1155071002782 Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to a subfamily of the PFKA family (cd00363) and include bacterial ATP-dependent...; Region: Bacterial_PFK; cd00763 1155071002783 6-phosphofructokinase; Region: PFKA_ATP; TIGR02482 1155071002784 active site 1155071002785 ADP/pyrophosphate binding site [chemical binding]; other site 1155071002786 dimerization interface [polypeptide binding]; other site 1155071002787 allosteric effector site; other site 1155071002788 fructose-1,6-bisphosphate binding site; other site 1155071002789 pyruvate kinase; Provisional; Region: PRK05826 1155071002790 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342 1155071002791 domain interfaces; other site 1155071002792 active site 1155071002793 Predicted membrane protein [Function unknown]; Region: COG2261 1155071002794 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 1155071002795 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 1155071002796 glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331 1155071002797 Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans). The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714 1155071002798 glutaminase active site [active] 1155071002799 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 1155071002800 dimer interface [polypeptide binding]; other site 1155071002801 active site 1155071002802 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 1155071002803 dimer interface [polypeptide binding]; other site 1155071002804 active site 1155071002805 Phosphotransferase system, mannitol-specific IIBC component [Carbohydrate transport and metabolism]; Region: MtlA; COG2213 1155071002806 PTS system, mannitol-specific IIC component; Region: mtlA; TIGR00851 1155071002807 PTS_IIB_mannitol: subunit IIB of enzyme II (EII) of the mannitol-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is a mannitol-specific permease with two cytoplasmic domains (IIA and IIB) and a transmembrane...; Region: PTS_IIB_mannitol; cd05567 1155071002808 active site 1155071002809 P-loop; other site 1155071002810 phosphorylation site [posttranslational modification] 1155071002811 PTS_IIB_mannitol: subunit IIB of enzyme II (EII) of the mannitol-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is a mannitol-specific permease with two cytoplasmic domains (IIA and IIB) and a transmembrane...; Region: PTS_IIB_mannitol; cd05567 1155071002812 active site 1155071002813 P-loop; other site 1155071002814 phosphorylation site [posttranslational modification] 1155071002815 Transcriptional antiterminator [Transcription]; Region: BglG; COG3711 1155071002816 HTH domain; Region: HTH_11; pfam08279 1155071002817 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cl00163 1155071002818 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 1155071002819 active site 1155071002820 phosphorylation site [posttranslational modification] 1155071002821 mannitol-1-phosphate 5-dehydrogenase; Provisional; Region: PRK02318 1155071002822 Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232 1155071002823 Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125 1155071002824 Uncharacterized Zn-ribbon-containing protein involved in phosphonate metabolism [Inorganic ion transport and metabolism]; Region: PhnA; COG2824 1155071002825 PhnA Zinc-Ribbon; Region: PhnA_Zn_Ribbon; pfam08274 1155071002826 PhnA protein; Region: PhnA; pfam03831 1155071002827 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 1155071002828 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1155071002829 dimer interface [polypeptide binding]; other site 1155071002830 conserved gate region; other site 1155071002831 ABC-ATPase subunit interface; other site 1155071002832 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 1155071002833 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1155071002834 Walker A/P-loop; other site 1155071002835 ATP binding site [chemical binding]; other site 1155071002836 Q-loop/lid; other site 1155071002837 ABC transporter signature motif; other site 1155071002838 Walker B; other site 1155071002839 D-loop; other site 1155071002840 H-loop/switch region; other site 1155071002841 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 1155071002842 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1155071002843 substrate binding pocket [chemical binding]; other site 1155071002844 membrane-bound complex binding site; other site 1155071002845 hinge residues; other site 1155071002846 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 1155071002847 cation diffusion facilitator family transporter; Region: CDF; TIGR01297 1155071002848 Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115 1155071002849 Sodium:alanine symporter family; Region: Na_Ala_symp; cl00548 1155071002850 ATP-dependent DNA helicase PcrA; Region: pcrA; TIGR01073 1155071002851 Part of AAA domain; Region: AAA_19; pfam13245 1155071002852 Family description; Region: UvrD_C_2; pfam13538 1155071002853 O-acetylhomoserine sulfhydrylase [Amino acid transport and metabolism]; Region: MET17; COG2873 1155071002854 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 1155071002855 homodimer interface [polypeptide binding]; other site 1155071002856 substrate-cofactor binding pocket; other site 1155071002857 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1155071002858 catalytic residue [active] 1155071002859 Kynurenine formamidase [Amino acid transport and metabolism]; Region: COG1878 1155071002860 HAD-superfamily hydrolase, subfamily IIB; Region: HAD-SF-IIB; TIGR01484 1155071002861 Cytochrome c biogenesis protein [Posttranslational modification, protein turnover, chaperones]; Region: CcdA; COG0785 1155071002862 Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788 1155071002863 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 1155071002864 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 1155071002865 catalytic residues [active] 1155071002866 probable dihydroxyacetone kinase regulator; Region: DHAK_reg; TIGR02366 1155071002867 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1155071002868 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 1155071002869 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 1155071002870 Walker A/P-loop; other site 1155071002871 ATP binding site [chemical binding]; other site 1155071002872 Q-loop/lid; other site 1155071002873 ABC transporter signature motif; other site 1155071002874 Walker B; other site 1155071002875 D-loop; other site 1155071002876 H-loop/switch region; other site 1155071002877 FtsX-like permease family; Region: FtsX; pfam02687 1155071002878 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 1155071002879 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 1155071002880 FtsX-like permease family; Region: FtsX; pfam02687 1155071002881 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1155071002882 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1155071002883 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 1155071002884 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1155071002885 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1155071002886 Walker A/P-loop; other site 1155071002887 ATP binding site [chemical binding]; other site 1155071002888 Q-loop/lid; other site 1155071002889 ABC transporter signature motif; other site 1155071002890 Walker B; other site 1155071002891 D-loop; other site 1155071002892 H-loop/switch region; other site 1155071002893 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 1155071002894 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1155071002895 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1155071002896 Walker A/P-loop; other site 1155071002897 ATP binding site [chemical binding]; other site 1155071002898 Q-loop/lid; other site 1155071002899 ABC transporter signature motif; other site 1155071002900 Walker B; other site 1155071002901 D-loop; other site 1155071002902 H-loop/switch region; other site 1155071002903 Restriction endonuclease; Region: Mrr_cat_2; pfam13156 1155071002904 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4487 1155071002905 Uncharacterized protein conserved in bacteria (DUF2130); Region: DUF2130; pfam09903 1155071002906 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 1155071002907 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1155071002908 Coenzyme A binding pocket [chemical binding]; other site 1155071002909 Domain of unknown function (DUF1858); Region: DUF1858; pfam08984 1155071002910 Uncharacterized conserved protein [Function unknown]; Region: COG2461 1155071002911 Family of unknown function (DUF438); Region: DUF438; pfam04282 1155071002912 Hemerythrin HHE cation binding domain; Region: Hemerythrin; pfam01814 1155071002913 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 1155071002914 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4200 1155071002915 lantibiotic protection ABC transporter permease subunit, MutG family; Region: lanti_perm_MutG; TIGR03733 1155071002916 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 1155071002917 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 1155071002918 ATP-binding cassette domain of the bacitracin-resistance transporter; Region: ABC_BcrA_bacitracin_resist; cd03268 1155071002919 Walker A/P-loop; other site 1155071002920 ATP binding site [chemical binding]; other site 1155071002921 Q-loop/lid; other site 1155071002922 ABC transporter signature motif; other site 1155071002923 Walker B; other site 1155071002924 D-loop; other site 1155071002925 H-loop/switch region; other site 1155071002926 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1155071002927 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1155071002928 active site 1155071002929 phosphorylation site [posttranslational modification] 1155071002930 intermolecular recognition site; other site 1155071002931 dimerization interface [polypeptide binding]; other site 1155071002932 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1155071002933 DNA binding site [nucleotide binding] 1155071002934 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1155071002935 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1155071002936 dimer interface [polypeptide binding]; other site 1155071002937 phosphorylation site [posttranslational modification] 1155071002938 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1155071002939 ATP binding site [chemical binding]; other site 1155071002940 Mg2+ binding site [ion binding]; other site 1155071002941 G-X-G motif; other site 1155071002942 tRNA pseudouridine synthase B; Provisional; Region: truB; PRK02484 1155071002943 Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573 1155071002944 RNA binding site [nucleotide binding]; other site 1155071002945 active site 1155071002946 bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627 1155071002947 FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064 1155071002948 active site 1155071002949 Riboflavin kinase; Region: Flavokinase; smart00904 1155071002950 Arsenate Reductase (ArsC) family, Spx subfamily; Spx is a unique RNA polymerase (RNAP)-binding protein present in bacilli and some mollicutes. It inhibits transcription by binding to the C-terminal domain of the alpha subunit of RNAP, disrupting complex...; Region: ArsC_Spx; cd03032 1155071002951 ArsC family; Region: ArsC; pfam03960 1155071002952 putative catalytic residues [active] 1155071002953 thiol/disulfide switch; other site 1155071002954 hypothetical protein; Provisional; Region: PRK04387 1155071002955 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 1155071002956 Inositol-monophosphatase-like domains. This family of phosphatases is dependent on bivalent metal ions such as Mg++, and many members are inhibited by Li+ (which is thought to displace a bivalent ion in the active site). Substrates include fructose-1; Region: IMPase_like; cd01637 1155071002957 active site 1155071002958 tRNA and rRNA cytosine-C5-methylases [Translation, ribosomal structure and biogenesis]; Region: Sun; COG0144 1155071002959 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1155071002960 S-adenosylmethionine binding site [chemical binding]; other site 1155071002961 Uncharacterized conserved protein [Function unknown]; Region: COG3270 1155071002962 pre-rRNA processing and ribosome biogenesis; Region: Nol1_Nop2_Fmu_2; pfam13636 1155071002963 PBP superfamily domain; Region: PBP_like_2; cl17296 1155071002964 ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstC; COG0573 1155071002965 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1155071002966 dimer interface [polypeptide binding]; other site 1155071002967 conserved gate region; other site 1155071002968 putative PBP binding loops; other site 1155071002969 ABC-ATPase subunit interface; other site 1155071002970 ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstA; COG0581 1155071002971 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1155071002972 dimer interface [polypeptide binding]; other site 1155071002973 conserved gate region; other site 1155071002974 putative PBP binding loops; other site 1155071002975 ABC-ATPase subunit interface; other site 1155071002976 phosphate transporter ATP-binding protein; Provisional; Region: PRK14237 1155071002977 ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260 1155071002978 Walker A/P-loop; other site 1155071002979 ATP binding site [chemical binding]; other site 1155071002980 Q-loop/lid; other site 1155071002981 ABC transporter signature motif; other site 1155071002982 Walker B; other site 1155071002983 D-loop; other site 1155071002984 H-loop/switch region; other site 1155071002985 phosphate transporter ATP-binding protein; Provisional; Region: PRK14239 1155071002986 ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260 1155071002987 Walker A/P-loop; other site 1155071002988 ATP binding site [chemical binding]; other site 1155071002989 Q-loop/lid; other site 1155071002990 ABC transporter signature motif; other site 1155071002991 Walker B; other site 1155071002992 D-loop; other site 1155071002993 H-loop/switch region; other site 1155071002994 phosphate transport system regulatory protein PhoU; Region: phoU_full; TIGR02135 1155071002995 PhoU domain; Region: PhoU; pfam01895 1155071002996 PhoU domain; Region: PhoU; pfam01895 1155071002997 Aminopeptidase N [Amino acid transport and metabolism]; Region: PepN; COG0308 1155071002998 Peptidase M1 Aminopeptidase N family incudes tricorn interacting factor F3, Endoplasmic reticulum aminopeptidase 1 (ERAP1), Aminopeptidase Q (APQ); Region: M1_APN_2; cd09601 1155071002999 Zn binding site [ion binding]; other site 1155071003000 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1155071003001 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1155071003002 active site 1155071003003 phosphorylation site [posttranslational modification] 1155071003004 intermolecular recognition site; other site 1155071003005 dimerization interface [polypeptide binding]; other site 1155071003006 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1155071003007 DNA binding site [nucleotide binding] 1155071003008 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1155071003009 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1155071003010 dimer interface [polypeptide binding]; other site 1155071003011 phosphorylation site [posttranslational modification] 1155071003012 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1155071003013 ATP binding site [chemical binding]; other site 1155071003014 Mg2+ binding site [ion binding]; other site 1155071003015 G-X-G motif; other site 1155071003016 30S ribosomal protein S20; Reviewed; Region: rpsT; PRK00239 1155071003017 pantothenate kinase; Provisional; Region: PRK05439 1155071003018 Pantothenate kinase (PanK) catalyzes the phosphorylation of pantothenic acid to form 4'-phosphopantothenic, which is the first of five steps in coenzyme A (CoA) biosynthetic pathway. The reaction carried out by this enzyme is a key regulatory point...; Region: PanK; cd02025 1155071003019 ATP-binding site [chemical binding]; other site 1155071003020 CoA-binding site [chemical binding]; other site 1155071003021 Mg2+-binding site [ion binding]; other site 1155071003022 16S RNA G1207 methylase RsmC [Translation, ribosomal structure and biogenesis]; Region: RsmC; COG2813 1155071003023 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1155071003024 S-adenosylmethionine binding site [chemical binding]; other site 1155071003025 pyrimidine-nucleoside phosphorylase; Reviewed; Region: PRK06078 1155071003026 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 1155071003027 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 1155071003028 Pyrimidine nucleoside phosphorylase C-terminal domain; Region: PYNP_C; pfam07831 1155071003029 2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family; Region: DeoC; cd00959 1155071003030 intersubunit interface [polypeptide binding]; other site 1155071003031 active site 1155071003032 catalytic residue [active] 1155071003033 Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283 1155071003034 active site 1155071003035 catalytic motif [active] 1155071003036 Zn binding site [ion binding]; other site 1155071003037 Uncharacterized ABC-type transport system, periplasmic component/surface lipoprotein [General function prediction only]; Region: Med; COG1744 1155071003038 Periplasmic binding domain of basic membrane lipoprotein, PnrA, in Treponema pallidum and its homologs from other bacteria and Archaea; Region: PBP1_BmpA_PnrA_like; cd06354 1155071003039 ligand binding site [chemical binding]; other site 1155071003040 ABC-type uncharacterized transport systems, ATPase components [General function prediction only]; Region: COG3845 1155071003041 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 1155071003042 Walker A/P-loop; other site 1155071003043 ATP binding site [chemical binding]; other site 1155071003044 Q-loop/lid; other site 1155071003045 ABC transporter signature motif; other site 1155071003046 Walker B; other site 1155071003047 D-loop; other site 1155071003048 H-loop/switch region; other site 1155071003049 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 1155071003050 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 1155071003051 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 1155071003052 TM-ABC transporter signature motif; other site 1155071003053 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 1155071003054 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 1155071003055 TM-ABC transporter signature motif; other site 1155071003056 coenzyme A disulfide reductase; Reviewed; Region: PRK09564 1155071003057 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1155071003058 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 1155071003059 L-lactate dehydrogenase; Reviewed; Region: ldh; PRK00066 1155071003060 L-2-hydroxyisocapronate dehydrogenases and some bacterial L-lactate dehydrogenases; Region: HicDH_like; cd05291 1155071003061 tetramer (dimer of dimers) interface [polypeptide binding]; other site 1155071003062 NAD binding site [chemical binding]; other site 1155071003063 dimer interface [polypeptide binding]; other site 1155071003064 substrate binding site [chemical binding]; other site 1155071003065 DNA gyrase subunit A; Validated; Region: PRK05560 1155071003066 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 1155071003067 CAP-like domain; other site 1155071003068 active site 1155071003069 primary dimer interface [polypeptide binding]; other site 1155071003070 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1155071003071 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1155071003072 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1155071003073 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1155071003074 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1155071003075 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1155071003076 Sortase A (SrtA) or subfamily-1 sortases are cysteine transpeptidases found in gram-positive bacteria that anchor surface proteins to peptidoglycans of the bacterial cell wall envelope. They do so by catalyzing a transpeptidation reaction in which the...; Region: Sortase_A_1; cd06165 1155071003077 active site 1155071003078 catalytic site [active] 1155071003079 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_1; cd08352 1155071003080 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1155071003081 putative metal binding site [ion binding]; other site 1155071003082 Predicted secreted protein [Function unknown]; Region: COG4086 1155071003083 Protein of unknown function (DUF1002); Region: DUF1002; pfam06207 1155071003084 Mn2+ and Fe2+ transporters of the NRAMP family [Inorganic ion transport and metabolism]; Region: MntH; COG1914 1155071003085 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1155071003086 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 1155071003087 active site 1155071003088 motif I; other site 1155071003089 motif II; other site 1155071003090 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 1155071003091 NnaC (CMP-NeuNAc synthetase) _like subfamily of SGNH_hydrolases, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its...; Region: NnaC_like; cd01841 1155071003092 active site 1155071003093 catalytic triad [active] 1155071003094 oxyanion hole [active] 1155071003095 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 1155071003096 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1155071003097 catalytic core [active] 1155071003098 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1155071003099 catalytic core [active] 1155071003100 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1155071003101 catalytic core [active] 1155071003102 6-phospho-beta-glucosidase; Reviewed; Region: arb; PRK09593 1155071003103 beta-galactosidase; Region: BGL; TIGR03356 1155071003104 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 1155071003105 Quinone oxidoreductase (QOR); Region: quinone_oxidoreductase_like_1; cd08243 1155071003106 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 1155071003107 putative NAD(P) binding site [chemical binding]; other site 1155071003108 Transcriptional regulators [Transcription]; Region: MarR; COG1846 1155071003109 MarR family; Region: MarR_2; pfam12802 1155071003110 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 1155071003111 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1155071003112 Walker A/P-loop; other site 1155071003113 ATP binding site [chemical binding]; other site 1155071003114 Q-loop/lid; other site 1155071003115 ABC transporter signature motif; other site 1155071003116 Walker B; other site 1155071003117 D-loop; other site 1155071003118 H-loop/switch region; other site 1155071003119 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1155071003120 dimer interface [polypeptide binding]; other site 1155071003121 conserved gate region; other site 1155071003122 ABC-ATPase subunit interface; other site 1155071003123 Periplasmic glycine betaine/choline-binding (lipo)protein of an ABC-type transport system (osmoprotectant binding protein) [Cell envelope biogenesis, outer membrane]; Region: OpuBC; COG1732 1155071003124 ABC-type proline/glycine betaine transport systems, periplasmic components [Amino acid transport and metabolism]; Region: ProX; cl17891 1155071003125 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 1155071003126 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 1155071003127 Walker A/P-loop; other site 1155071003128 ATP binding site [chemical binding]; other site 1155071003129 Q-loop/lid; other site 1155071003130 ABC transporter signature motif; other site 1155071003131 Walker B; other site 1155071003132 D-loop; other site 1155071003133 H-loop/switch region; other site 1155071003134 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 1155071003135 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 1155071003136 FtsX-like permease family; Region: FtsX; pfam02687 1155071003137 putative cross-wall-targeting lipoprotein signal; Region: strep_RK_lipo; TIGR03726 1155071003138 Predicted flavoprotein [General function prediction only]; Region: COG0431 1155071003139 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 1155071003140 PAS domain; Region: PAS_10; pfam13596 1155071003141 Predicted flavoprotein [General function prediction only]; Region: COG0431 1155071003142 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 1155071003143 Membrane-associated lipoprotein involved in thiamine biosynthesis [Coenzyme metabolism]; Region: ApbE; COG1477 1155071003144 ApbE family; Region: ApbE; pfam02424 1155071003145 4-oxalocrotonate tautomerase; Provisional; Region: PRK02289 1155071003146 active site 1 [active] 1155071003147 dimer interface [polypeptide binding]; other site 1155071003148 hexamer interface [polypeptide binding]; other site 1155071003149 active site 2 [active] 1155071003150 thymidine kinase; Provisional; Region: PRK04296 1155071003151 peptide chain release factor 1; Validated; Region: prfA; PRK00591 1155071003152 This domain is found in peptide chain release factors; Region: PCRF; smart00937 1155071003153 RF-1 domain; Region: RF-1; pfam00472 1155071003154 protein-(glutamine-N5) methyltransferase, release factor-specific; Region: RF_mod_PrmC; TIGR03534 1155071003155 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1155071003156 S-adenosylmethionine binding site [chemical binding]; other site 1155071003157 Putative translation factor (SUA5) [Translation, ribosomal structure and biogenesis]; Region: SUA5; COG0009 1155071003158 serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011 1155071003159 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378 1155071003160 dimer interface [polypeptide binding]; other site 1155071003161 active site 1155071003162 glycine-pyridoxal phosphate binding site [chemical binding]; other site 1155071003163 folate binding site [chemical binding]; other site 1155071003164 37-kD nucleoid-associated bacterial protein; Region: NA37; pfam04245 1155071003165 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 1155071003166 N-acetyl-D-glucosamine binding site [chemical binding]; other site 1155071003167 catalytic residue [active] 1155071003168 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 1155071003169 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1155071003170 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1155071003171 Walker A/P-loop; other site 1155071003172 ATP binding site [chemical binding]; other site 1155071003173 Q-loop/lid; other site 1155071003174 ABC transporter signature motif; other site 1155071003175 Walker B; other site 1155071003176 D-loop; other site 1155071003177 H-loop/switch region; other site 1155071003178 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 1155071003179 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1155071003180 ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254 1155071003181 Walker A/P-loop; other site 1155071003182 ATP binding site [chemical binding]; other site 1155071003183 Q-loop/lid; other site 1155071003184 ABC transporter signature motif; other site 1155071003185 Walker B; other site 1155071003186 D-loop; other site 1155071003187 H-loop/switch region; other site 1155071003188 phosphoglucomutase-2-like protein; Provisional; Region: PTZ00150 1155071003189 This CD includes PGM2 (phosphoglucomutase 2) and PGM2L1 (phosphoglucomutase 2-like 1). The mammalian PGM2 is thought to be a phosphopentomutase that catalyzes the conversion of the nucleoside breakdown products, ribose-1-phosphate and...; Region: PGM2; cd05799 1155071003190 active site 1155071003191 substrate binding site [chemical binding]; other site 1155071003192 metal binding site [ion binding]; metal-binding site 1155071003193 Predicted membrane protein [Function unknown]; Region: COG4684 1155071003194 phosphopantothenoylcysteine decarboxylase, streptococcal; Region: coaC_strep; TIGR02113 1155071003195 Flavoprotein; Region: Flavoprotein; pfam02441 1155071003196 phosphopantothenate--cysteine ligase; Validated; Region: PRK06732 1155071003197 formate--tetrahydrofolate ligase; Provisional; Region: PRK13505 1155071003198 Formyltetrahydrofolate synthetase (FTHFS) catalyzes the ATP-dependent activation of formate ion via its addition to the N10 position of tetrahydrofolate. FTHFS is a highly expressed key enzyme in both the Wood-Ljungdahl pathway of autotrophic CO2...; Region: FTHFS; cd00477 1155071003199 Potassium binding sites [ion binding]; other site 1155071003200 Cesium cation binding sites [ion binding]; other site 1155071003201 Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247 1155071003202 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 1155071003203 Alpha/beta hydrolase of unknown function (DUF915); Region: DUF915; pfam06028 1155071003204 LytTr DNA-binding domain; Region: LytTR; pfam04397 1155071003205 Protein of unknown function (DUF3021); Region: DUF3021; pfam11457 1155071003206 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 1155071003207 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 1155071003208 Walker A/P-loop; other site 1155071003209 ATP binding site [chemical binding]; other site 1155071003210 Q-loop/lid; other site 1155071003211 ABC transporter signature motif; other site 1155071003212 Walker B; other site 1155071003213 D-loop; other site 1155071003214 H-loop/switch region; other site 1155071003215 ABC-2 family transporter protein; Region: ABC2_membrane_2; cl17866 1155071003216 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 1155071003217 GMP synthase; Reviewed; Region: guaA; PRK00074 1155071003218 Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742 1155071003219 AMP/PPi binding site [chemical binding]; other site 1155071003220 candidate oxyanion hole; other site 1155071003221 catalytic triad [active] 1155071003222 potential glutamine specificity residues [chemical binding]; other site 1155071003223 The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997 1155071003224 ATP Binding subdomain [chemical binding]; other site 1155071003225 Dimerization subdomain; other site 1155071003226 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 1155071003227 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1155071003228 DNA-binding site [nucleotide binding]; DNA binding site 1155071003229 UTRA domain; Region: UTRA; pfam07702 1155071003230 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 1155071003231 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1155071003232 DNA-binding site [nucleotide binding]; DNA binding site 1155071003233 TrkA-C domain; Region: TrkA_C; pfam02080 1155071003234 ABC-type proline/glycine betaine transport system, ATPase component [Amino acid transport and metabolism]; Region: ProV; COG4175 1155071003235 ATP-binding cassette domain of the osmoprotectant proline/glycine betaine uptake system; Region: ABC_Pro_Gly_Betaine; cd03294 1155071003236 Walker A/P-loop; other site 1155071003237 ATP binding site [chemical binding]; other site 1155071003238 Q-loop/lid; other site 1155071003239 ABC transporter signature motif; other site 1155071003240 Walker B; other site 1155071003241 D-loop; other site 1155071003242 H-loop/switch region; other site 1155071003243 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 1155071003244 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1155071003245 dimer interface [polypeptide binding]; other site 1155071003246 conserved gate region; other site 1155071003247 putative PBP binding loops; other site 1155071003248 ABC-ATPase subunit interface; other site 1155071003249 ABC-type proline/glycine betaine transport systems, periplasmic components [Amino acid transport and metabolism]; Region: ProX; COG2113 1155071003250 Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069 1155071003251 putative DNA-binding protein; Validated; Region: PRK00118 1155071003252 Putative helix-turn-helix protein, YlxM / p13 like; Region: UPF0122; pfam04297 1155071003253 signal recognition particle protein; Provisional; Region: PRK10867 1155071003254 SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963 1155071003255 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 1155071003256 P loop; other site 1155071003257 GTP binding site [chemical binding]; other site 1155071003258 Signal peptide binding domain; Region: SRP_SPB; pfam02978 1155071003259 6-pyruvoyl-tetrahydropterin synthase related domain; membrane protein; Region: PTPS_related; pfam10131 1155071003260 Protein of unknown function (DUF3307); Region: DUF3307; pfam11750 1155071003261 hypothetical protein; Reviewed; Region: PRK00024 1155071003262 Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071 1155071003263 MPN+ (JAMM) motif; other site 1155071003264 Zinc-binding site [ion binding]; other site 1155071003265 Peptidase C26; Region: Peptidase_C26; pfam07722 1155071003266 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_2; cd01745 1155071003267 catalytic triad [active] 1155071003268 redox-sensing transcriptional repressor Rex; Provisional; Region: PRK05472 1155071003269 Putative DNA-binding protein N-terminus; Region: Put_DNA-bind_N; pfam06971 1155071003270 CoA binding domain; Region: CoA_binding; pfam02629 1155071003271 Putative amino acid metabolism; Region: DUF1831; pfam08866 1155071003272 Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104 1155071003273 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 1155071003274 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1155071003275 catalytic residue [active] 1155071003276 ribose-phosphate pyrophosphokinase; Provisional; Region: PRK02458 1155071003277 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 1155071003278 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1155071003279 active site 1155071003280 Uncharacterized subgroup 1 of the CYTH-like superfamily; Region: CYTH-like_Pase_1; cd07762 1155071003281 putative active site [active] 1155071003282 putative metal binding residues [ion binding]; other site 1155071003283 signature motif; other site 1155071003284 putative triphosphate binding site [ion binding]; other site 1155071003285 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 1155071003286 synthetase active site [active] 1155071003287 NTP binding site [chemical binding]; other site 1155071003288 metal binding site [ion binding]; metal-binding site 1155071003289 inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK04885 1155071003290 ATP-NAD kinase; Region: NAD_kinase; pfam01513 1155071003291 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 1155071003292 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 1155071003293 active site 1155071003294 phosphotransacetylase; Reviewed; Region: eutD; PRK09653 1155071003295 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 1155071003296 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 1155071003297 Walker A/P-loop; other site 1155071003298 ATP binding site [chemical binding]; other site 1155071003299 Q-loop/lid; other site 1155071003300 ABC transporter signature motif; other site 1155071003301 Walker B; other site 1155071003302 D-loop; other site 1155071003303 H-loop/switch region; other site 1155071003304 classical (c) SDR, subgroup 5; Region: SDR_c5; cd05346 1155071003305 malonic semialdehyde reductase; Provisional; Region: PRK10538 1155071003306 putative NAD(P) binding site [chemical binding]; other site 1155071003307 homotetramer interface [polypeptide binding]; other site 1155071003308 homodimer interface [polypeptide binding]; other site 1155071003309 active site 1155071003310 A4GalT_like proteins catalyze the addition of galactose or glucose residues to the lipooligosaccharide (LOS) or lipopolysaccharide (LPS) of the bacterial cell surface; Region: GT8_A4GalT_like; cd04194 1155071003311 Glycosyl transferase family 8; Region: Glyco_transf_8; pfam01501 1155071003312 Ligand binding site; other site 1155071003313 metal-binding site 1155071003314 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1155071003315 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1155071003316 active site 1155071003317 phosphorylation site [posttranslational modification] 1155071003318 intermolecular recognition site; other site 1155071003319 dimerization interface [polypeptide binding]; other site 1155071003320 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1155071003321 DNA binding site [nucleotide binding] 1155071003322 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1155071003323 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1155071003324 dimer interface [polypeptide binding]; other site 1155071003325 phosphorylation site [posttranslational modification] 1155071003326 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1155071003327 ATP binding site [chemical binding]; other site 1155071003328 Mg2+ binding site [ion binding]; other site 1155071003329 G-X-G motif; other site 1155071003330 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 1155071003331 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 1155071003332 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1155071003333 Walker A/P-loop; other site 1155071003334 ATP binding site [chemical binding]; other site 1155071003335 Q-loop/lid; other site 1155071003336 ABC transporter signature motif; other site 1155071003337 Walker B; other site 1155071003338 D-loop; other site 1155071003339 H-loop/switch region; other site 1155071003340 site-specific tyrosine recombinase XerS; Reviewed; Region: xerS; PRK05084 1155071003341 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 1155071003342 active site 1155071003343 DNA binding site [nucleotide binding] 1155071003344 Int/Topo IB signature motif; other site 1155071003345 DNA binding domain of tn916 integrase; Region: Integrase_DNA; pfam02920 1155071003346 Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582 1155071003347 Tn1545-related conjugative transposon integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes bacterial (gram positive) and phage integrases, including those similar to Tn1545, Tn5252, and...; Region: INT_Tn1545_C; cd01199 1155071003348 Int/Topo IB signature motif; other site 1155071003349 Excisionase from transposon Tn916; Region: Tn916-Xis; pfam09035 1155071003350 Helix-turn-helix domain; Region: HTH_16; pfam12645 1155071003351 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 1155071003352 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1155071003353 DNA binding residues [nucleotide binding] 1155071003354 Cysteine-rich KTR; Region: Cys_rich_KTR; pfam14205 1155071003355 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1155071003356 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 1155071003357 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1155071003358 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1155071003359 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1155071003360 MarR family; Region: MarR_2; pfam12802 1155071003361 Integrase core domain; Region: rve_3; cl15866 1155071003362 oxaloacetate decarboxylase; Provisional; Region: PRK12331 1155071003363 Pyruvate carboxylase and Transcarboxylase 5S, carboxyltransferase domain; Region: DRE_TIM_PC_TC_5S; cd07937 1155071003364 active site 1155071003365 catalytic residues [active] 1155071003366 metal binding site [ion binding]; metal-binding site 1155071003367 homodimer binding site [polypeptide binding]; other site 1155071003368 2'-(5''-triphosphoribosyl)-3'- dephospho-CoA:apo-citrate lyase; Reviewed; Region: citX; PRK01392 1155071003369 Citrate lyase, alpha subunit (CitF); Region: CitF; pfam04223 1155071003370 Acetyl-CoA hydrolase/transferase C-terminal domain; Region: AcetylCoA_hyd_C; pfam13336 1155071003371 HpcH/HpaI aldolase/citrate lyase family; Region: HpcH_HpaI; cl17231 1155071003372 citrate lyase subunit gamma; Provisional; Region: PRK13253 1155071003373 Oxaloacetate decarboxylase, gamma chain; Region: OAD_gamma; pfam04277 1155071003374 Na+-transporting oxaloacetate decarboxylase beta subunit; Region: OAD_beta; pfam03977 1155071003375 acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated; Region: PRK06549 1155071003376 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 1155071003377 carboxyltransferase (CT) interaction site; other site 1155071003378 biotinylation site [posttranslational modification]; other site 1155071003379 H+/citrate symporter [Energy production and conversion]; Region: CitM; COG2851 1155071003380 Citrate transporter; Region: CitMHS; pfam03600 1155071003381 Transcriptional regulators [Transcription]; Region: GntR; COG1802 1155071003382 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1155071003383 DNA-binding site [nucleotide binding]; DNA binding site 1155071003384 FCD domain; Region: FCD; pfam07729 1155071003385 triphosphoribosyl-dephospho-CoA synthase CitG; Region: citrate_citG; TIGR03125 1155071003386 Citrate lyase synthetase [Energy production and conversion]; Region: CitC; COG3053 1155071003387 Citrate lyase ligase; Region: Citrate_lyase_ligase; cd02169 1155071003388 putative active site [active] 1155071003389 (T/H)XGH motif; other site 1155071003390 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1155071003391 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1155071003392 ATP binding site [chemical binding]; other site 1155071003393 Mg2+ binding site [ion binding]; other site 1155071003394 G-X-G motif; other site 1155071003395 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1155071003396 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1155071003397 active site 1155071003398 phosphorylation site [posttranslational modification] 1155071003399 intermolecular recognition site; other site 1155071003400 dimerization interface [polypeptide binding]; other site 1155071003401 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1155071003402 DNA binding site [nucleotide binding] 1155071003403 FtsX-like permease family; Region: FtsX; pfam02687 1155071003404 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 1155071003405 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 1155071003406 Walker A/P-loop; other site 1155071003407 ATP binding site [chemical binding]; other site 1155071003408 Q-loop/lid; other site 1155071003409 ABC transporter signature motif; other site 1155071003410 Walker B; other site 1155071003411 D-loop; other site 1155071003412 H-loop/switch region; other site 1155071003413 Glycosyl hydrolase family 70; Region: Glyco_hydro_70; pfam02324 1155071003414 Alpha amylase catalytic domain family; Region: AmyAc_family; cl07893 1155071003415 Putative cell wall binding repeat; Region: CW_binding_1; pfam01473 1155071003416 glucan-binding repeat; Region: glucan_65_rpt; TIGR04035 1155071003417 glucan-binding repeat; Region: glucan_65_rpt; TIGR04035 1155071003418 glucan-binding repeat; Region: glucan_65_rpt; TIGR04035 1155071003419 glucan-binding repeat; Region: glucan_65_rpt; TIGR04035 1155071003420 glucan-binding repeat; Region: glucan_65_rpt; TIGR04035 1155071003421 Glycosyl hydrolase family 70; Region: Glyco_hydro_70; pfam02324 1155071003422 Alpha amylase catalytic domain family; Region: AmyAc_family; cl07893 1155071003423 Putative cell wall binding repeat; Region: CW_binding_1; pfam01473 1155071003424 glucan-binding repeat; Region: glucan_65_rpt; TIGR04035 1155071003425 glucan-binding repeat; Region: glucan_65_rpt; TIGR04035 1155071003426 glucan-binding repeat; Region: glucan_65_rpt; TIGR04035 1155071003427 glucan-binding repeat; Region: glucan_65_rpt; TIGR04035 1155071003428 glucan-binding repeat; Region: glucan_65_rpt; TIGR04035 1155071003429 glucan-binding repeat; Region: glucan_65_rpt; TIGR04035 1155071003430 tRNA (uracil-5-)-methyltransferase Gid; Reviewed; Region: PRK05335 1155071003431 Glucose inhibited division protein A; Region: GIDA; pfam01134 1155071003432 DNA topoisomerase I; Validated; Region: PRK05582 1155071003433 TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I. Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363 1155071003434 active site 1155071003435 interdomain interaction site; other site 1155071003436 putative metal-binding site [ion binding]; other site 1155071003437 nucleotide binding site [chemical binding]; other site 1155071003438 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 1155071003439 domain I; other site 1155071003440 DNA binding groove [nucleotide binding] 1155071003441 phosphate binding site [ion binding]; other site 1155071003442 domain II; other site 1155071003443 domain III; other site 1155071003444 nucleotide binding site [chemical binding]; other site 1155071003445 catalytic site [active] 1155071003446 domain IV; other site 1155071003447 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 1155071003448 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 1155071003449 DNA recombination-mediator protein A; Region: DNA_processg_A; pfam02481 1155071003450 DNA protecting protein DprA; Region: dprA; TIGR00732 1155071003451 ABC-type enterochelin transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: CeuA; COG4607 1155071003452 Siderophore binding protein FatB. These proteins have been shown to function as ABC-type initial receptors in the siderophore-mediated iron uptake in some eubacterial species. They belong to the TroA superfamily of periplasmic metal binding proteins...; Region: FatB; cd01140 1155071003453 putative ligand binding residues [chemical binding]; other site 1155071003454 ABC-type enterochelin transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CeuD; COG4604 1155071003455 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 1155071003456 Walker A/P-loop; other site 1155071003457 ATP binding site [chemical binding]; other site 1155071003458 Q-loop/lid; other site 1155071003459 ABC transporter signature motif; other site 1155071003460 Walker B; other site 1155071003461 D-loop; other site 1155071003462 H-loop/switch region; other site 1155071003463 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1155071003464 ABC-ATPase subunit interface; other site 1155071003465 dimer interface [polypeptide binding]; other site 1155071003466 putative PBP binding regions; other site 1155071003467 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cl00462 1155071003468 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 1155071003469 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1155071003470 ABC-ATPase subunit interface; other site 1155071003471 dimer interface [polypeptide binding]; other site 1155071003472 putative PBP binding regions; other site 1155071003473 bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182 1155071003474 RNA/DNA hybrid binding site [nucleotide binding]; other site 1155071003475 active site 1155071003476 GTPase YlqF; Reviewed; Region: rbgA; PRK09563 1155071003477 Circularly permuted YlqF GTPase; Region: YlqF; cd01856 1155071003478 GTP/Mg2+ binding site [chemical binding]; other site 1155071003479 G4 box; other site 1155071003480 G5 box; other site 1155071003481 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 1155071003482 G1 box; other site 1155071003483 G1 box; other site 1155071003484 GTP/Mg2+ binding site [chemical binding]; other site 1155071003485 Switch I region; other site 1155071003486 G2 box; other site 1155071003487 G2 box; other site 1155071003488 G3 box; other site 1155071003489 G3 box; other site 1155071003490 Switch II region; other site 1155071003491 Switch II region; other site 1155071003492 G5 box; other site 1155071003493 ATP cone domain; Region: ATP-cone; pfam03477 1155071003494 Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950 1155071003495 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 1155071003496 dimer interface [polypeptide binding]; other site 1155071003497 active site 1155071003498 catalytic residue [active] 1155071003499 aspartate-semialdehyde dehydrogenase; Provisional; Region: PRK14874 1155071003500 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 1155071003501 Asd RNA motif; asd 1155071003502 Phospholipase_D-nuclease N-terminal; Region: PLDc_N; pfam13396 1155071003503 Phosphatidylserine/phosphatidylglycerophosphate/car diolipin synthases and related enzymes [Lipid metabolism]; Region: Cls; COG1502 1155071003504 Putative catalytic domain, repeat 1, of Streptococcus mutans uncharacterized protein SMU_988 and similar proteins; Region: PLDc_SMU_988_like_1; cd09154 1155071003505 putative active site [active] 1155071003506 catalytic site [active] 1155071003507 Putative catalytic domain, repeat 2, of Streptococcus mutans uncharacterized protein SMU_988 and similar proteins; Region: PLDc_SMU_988_like_2; cd09160 1155071003508 putative active site [active] 1155071003509 catalytic site [active] 1155071003510 Collagen binding domain; Region: Collagen_bind; pfam05737 1155071003511 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1155071003512 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1155071003513 non-specific DNA binding site [nucleotide binding]; other site 1155071003514 salt bridge; other site 1155071003515 sequence-specific DNA binding site [nucleotide binding]; other site 1155071003516 Beta-glucosidase/6-phospho-beta-glucosidase/beta- galactosidase [Carbohydrate transport and metabolism]; Region: BglB; COG2723 1155071003517 beta-galactosidase; Region: BGL; TIGR03356 1155071003518 CHAP domain; Region: CHAP; pfam05257 1155071003519 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 1155071003520 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 1155071003521 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1155071003522 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1155071003523 Predicted peptidase [General function prediction only]; Region: COG4099 1155071003524 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 1155071003525 PTS system, beta-glucoside-specific IIABC component; Region: PTS-II-ABC-beta; TIGR01995 1155071003526 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 1155071003527 active site turn [active] 1155071003528 phosphorylation site [posttranslational modification] 1155071003529 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 1155071003530 PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_glc; cd00210 1155071003531 HPr interaction site; other site 1155071003532 glycerol kinase (GK) interaction site [polypeptide binding]; other site 1155071003533 active site 1155071003534 phosphorylation site [posttranslational modification] 1155071003535 transcriptional antiterminator BglG; Provisional; Region: PRK09772 1155071003536 CAT RNA binding domain; Region: CAT_RBD; smart01061 1155071003537 PRD domain; Region: PRD; pfam00874 1155071003538 PRD domain; Region: PRD; pfam00874 1155071003539 Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687 1155071003540 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 1155071003541 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 1155071003542 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1155071003543 dimer interface [polypeptide binding]; other site 1155071003544 conserved gate region; other site 1155071003545 putative PBP binding loops; other site 1155071003546 ABC-ATPase subunit interface; other site 1155071003547 sulfate transport protein; Provisional; Region: cysT; CHL00187 1155071003548 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1155071003549 dimer interface [polypeptide binding]; other site 1155071003550 conserved gate region; other site 1155071003551 putative PBP binding loops; other site 1155071003552 ABC-ATPase subunit interface; other site 1155071003553 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 1155071003554 ATP-binding cassette domain of the polyamine transporter; Region: ABC_PotA_N; cd03300 1155071003555 Walker A/P-loop; other site 1155071003556 ATP binding site [chemical binding]; other site 1155071003557 Q-loop/lid; other site 1155071003558 ABC transporter signature motif; other site 1155071003559 Walker B; other site 1155071003560 D-loop; other site 1155071003561 H-loop/switch region; other site 1155071003562 TOBE domain; Region: TOBE_2; pfam08402 1155071003563 UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK13905 1155071003564 FAD binding domain; Region: FAD_binding_4; pfam01565 1155071003565 UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873 1155071003566 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483 1155071003567 catalytic center binding site [active] 1155071003568 ATP binding site [chemical binding]; other site 1155071003569 Dihydroneopterin aldolase (DHNA) and 7,8-dihydroneopterin triphosphate epimerase domain (DHNTPE); these enzymes have been designated folB and folX, respectively. Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and...; Region: DHNA_DHNTPE; cd00534 1155071003570 homooctamer interface [polypeptide binding]; other site 1155071003571 active site 1155071003572 DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739 1155071003573 dihydropteroate synthase; Region: DHPS; TIGR01496 1155071003574 substrate binding pocket [chemical binding]; other site 1155071003575 dimer interface [polypeptide binding]; other site 1155071003576 inhibitor binding site; inhibition site 1155071003577 GTP cyclohydrolase I (GTP-CH-I) catalyzes the conversion of GTP into dihydroneopterin triphosphate. The enzyme product is the precursor of tetrahydrofolate in eubacteria, fungi, and plants and of the folate analogs in methanogenic bacteria. In...; Region: GTP_cyclohydro1; cd00642 1155071003578 homodecamer interface [polypeptide binding]; other site 1155071003579 GTP cyclohydrolase I; Provisional; Region: PLN03044 1155071003580 active site 1155071003581 putative catalytic site residues [active] 1155071003582 zinc binding site [ion binding]; other site 1155071003583 GTP-CH-I/GFRP interaction surface; other site 1155071003584 Folylpolyglutamate synthase [Coenzyme metabolism]; Region: FolC; COG0285 1155071003585 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 1155071003586 homoserine kinase; Provisional; Region: PRK01212 1155071003587 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 1155071003588 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 1155071003589 homoserine dehydrogenase; Provisional; Region: PRK06349 1155071003590 Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447 1155071003591 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 1155071003592 ACT_HSDH_Hom CD includes the C-terminal ACT domain of the NAD(P)H-dependent, homoserine dehydrogenase (HSDH) and related domains; Region: ACT_HSDH-Hom; cd04881 1155071003593 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 1155071003594 Putative catalytic NodB homology domain of PgaB, IcaB, and similar proteins which consist of a deformed (beta/alpha)8 barrel fold with 5- or 6-strands; Region: CE4_NodB_like_5s_6s; cd10918 1155071003595 putative active site [active] 1155071003596 putative metal binding site [ion binding]; other site 1155071003597 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1155071003598 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1155071003599 active site 1155071003600 Uncharacterized conserved protein [Function unknown]; Region: COG2128 1155071003601 Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627 1155071003602 Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387 1155071003603 core dimer interface [polypeptide binding]; other site 1155071003604 L10 interface [polypeptide binding]; other site 1155071003605 L11 interface [polypeptide binding]; other site 1155071003606 putative EF-Tu interaction site [polypeptide binding]; other site 1155071003607 putative EF-G interaction site [polypeptide binding]; other site 1155071003608 Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797 1155071003609 23S rRNA interface [nucleotide binding]; other site 1155071003610 Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site 1155071003611 L10_leader; Ribosomal protein L10 leader 1155071003612 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1155071003613 ATPases of the AAA+ class [Posttranslational modification, protein turnover, chaperones]; Region: SpoVK; COG0464 1155071003614 Walker A motif; other site 1155071003615 ATP binding site [chemical binding]; other site 1155071003616 Walker B motif; other site 1155071003617 arginine finger; other site 1155071003618 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1155071003619 Walker A motif; other site 1155071003620 ATP binding site [chemical binding]; other site 1155071003621 Walker B motif; other site 1155071003622 arginine finger; other site 1155071003623 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 1155071003624 Predicted membrane protein [Function unknown]; Region: COG4720 1155071003625 Pyridoxal kinase plays a key role in the synthesis of the active coenzyme pyridoxal-5'-phosphate (PLP), by catalyzing the phosphorylation of the precursor vitamin B6 in the presence of Zn2+ and ATP. Mammals are unable to synthesize PLP de novo and...; Region: pyridoxal_pyridoxamine_kinase; cd01173 1155071003626 dimer interface [polypeptide binding]; other site 1155071003627 pyridoxal binding site [chemical binding]; other site 1155071003628 ATP binding site [chemical binding]; other site 1155071003629 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 1155071003630 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1155071003631 DNA-binding site [nucleotide binding]; DNA binding site 1155071003632 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1155071003633 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1155071003634 homocysteine methyltransferase; Provisional; Region: mmuM; PRK09485 1155071003635 Homocysteine S-methyltransferase; Region: S-methyl_trans; pfam02574 1155071003636 S-methylmethionine transporter; Provisional; Region: PRK11387 1155071003637 YihA (EngB) GTPase family; Region: YihA_EngB; cd01876 1155071003638 G1 box; other site 1155071003639 GTP/Mg2+ binding site [chemical binding]; other site 1155071003640 Switch I region; other site 1155071003641 G2 box; other site 1155071003642 G3 box; other site 1155071003643 Switch II region; other site 1155071003644 G4 box; other site 1155071003645 G5 box; other site 1155071003646 ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342 1155071003647 ClpX C4-type zinc finger; Region: zf-C4_ClpX; pfam06689 1155071003648 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1155071003649 Walker A motif; other site 1155071003650 ATP binding site [chemical binding]; other site 1155071003651 Walker B motif; other site 1155071003652 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 1155071003653 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 1155071003654 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cd00209 1155071003655 folate binding site [chemical binding]; other site 1155071003656 NADP+ binding site [chemical binding]; other site 1155071003657 Nicotinamide mononucleotide transporter; Region: NMN_transporter; pfam04973 1155071003658 thymidylate synthase; Reviewed; Region: thyA; PRK01827 1155071003659 Thymidylate synthase and pyrimidine hydroxymethylase: Thymidylate synthase (TS) and deoxycytidylate hydroxymethylase (dCMP-HMase) are homologs that catalyze analogous alkylation of C5 of pyrimidine nucleotides. Both enzymes are involved in the...; Region: TS_Pyrimidine_HMase; cd00351 1155071003660 dimerization interface [polypeptide binding]; other site 1155071003661 active site 1155071003662 3-hydroxy-3-methylglutaryl CoA synthase, prokaryotic clade; Region: HMG-CoA-S_prok; TIGR01835 1155071003663 "initiating" condensing enzymes are a subclass of decarboxylating condensing enzymes, including beta-ketoacyl [ACP] synthase, type III and polyketide synthases, type III, which include chalcone synthase and related enzymes. They are...; Region: init_cond_enzymes; cd00827 1155071003664 dimer interface [polypeptide binding]; other site 1155071003665 active site 1155071003666 Class II hydroxymethylglutaryl-coenzyme A (HMG-CoA) reductase (HMGR); Region: HMG-CoA_reductase_classII; cd00644 1155071003667 homodimer interface [polypeptide binding]; other site 1155071003668 catalytic residues [active] 1155071003669 NAD binding site [chemical binding]; other site 1155071003670 substrate binding pocket [chemical binding]; other site 1155071003671 flexible flap; other site 1155071003672 Domain of unknown function (DUF1836); Region: DUF1836; pfam08876 1155071003673 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 1155071003674 Predicted membrane protein, hemolysin III homolog [General function prediction only]; Region: COG1272 1155071003675 channel protein, hemolysin III family; Region: hlyIII; TIGR01065 1155071003676 isopentenyl pyrophosphate isomerase; Provisional; Region: PRK05437 1155071003677 Isopentenyl-diphosphate:dimethylallyl diphosphate isomerase type 2 (IDI-2) FMN-binding domain. Two types of IDIs have been characterized at present. The long known IDI-1 is only dependent on divalent metals for activity, whereas IDI-2 requires a metal; Region: IDI-2_FMN; cd02811 1155071003678 homotetramer interface [polypeptide binding]; other site 1155071003679 FMN binding site [chemical binding]; other site 1155071003680 homodimer contacts [polypeptide binding]; other site 1155071003681 putative active site [active] 1155071003682 putative substrate binding site [chemical binding]; other site 1155071003683 Mevalonate kinase [Lipid metabolism]; Region: ERG12; COG1577 1155071003684 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 1155071003685 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 1155071003686 diphosphomevalonate decarboxylase; Region: PLN02407 1155071003687 diphosphomevalonate decarboxylase; Region: mevDPdecarb; TIGR01240 1155071003688 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 1155071003689 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 1155071003690 Walker A/P-loop; other site 1155071003691 ATP binding site [chemical binding]; other site 1155071003692 Q-loop/lid; other site 1155071003693 ABC transporter signature motif; other site 1155071003694 Walker B; other site 1155071003695 D-loop; other site 1155071003696 H-loop/switch region; other site 1155071003697 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 1155071003698 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1155071003699 dimer interface [polypeptide binding]; other site 1155071003700 conserved gate region; other site 1155071003701 putative PBP binding loops; other site 1155071003702 ABC-ATPase subunit interface; other site 1155071003703 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1155071003704 dimer interface [polypeptide binding]; other site 1155071003705 conserved gate region; other site 1155071003706 putative PBP binding loops; other site 1155071003707 ABC-ATPase subunit interface; other site 1155071003708 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 1155071003709 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1155071003710 substrate binding pocket [chemical binding]; other site 1155071003711 membrane-bound complex binding site; other site 1155071003712 hinge residues; other site 1155071003713 The URO-D _like protein superfamily includes bacterial and eukaryotic uroporphyrinogen decarboxylases (URO-D), coenzyme M methyltransferases and other putative bacterial methyltransferases. Uroporphyrinogen decarboxylase (URO-D) decarboxylates the four...; Region: URO-D_like; cd03465 1155071003714 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1155071003715 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1155071003716 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 1155071003717 dimerization interface [polypeptide binding]; other site 1155071003718 Protein of unknown function (DUF1304); Region: DUF1304; cl01533 1155071003719 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1155071003720 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1155071003721 dimer interface [polypeptide binding]; other site 1155071003722 phosphorylation site [posttranslational modification] 1155071003723 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1155071003724 ATP binding site [chemical binding]; other site 1155071003725 Mg2+ binding site [ion binding]; other site 1155071003726 G-X-G motif; other site 1155071003727 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1155071003728 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1155071003729 active site 1155071003730 phosphorylation site [posttranslational modification] 1155071003731 intermolecular recognition site; other site 1155071003732 dimerization interface [polypeptide binding]; other site 1155071003733 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1155071003734 DNA binding site [nucleotide binding] 1155071003735 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 1155071003736 synthetase active site [active] 1155071003737 NTP binding site [chemical binding]; other site 1155071003738 metal binding site [ion binding]; metal-binding site 1155071003739 Peroxiredoxin (PRX) family, Atypical 2-cys PRX subfamily; composed of PRXs containing peroxidatic and resolving cysteines, similar to the homodimeric thiol specific antioxidant (TSA) protein also known as TRX-dependent thiol peroxidase (Tpx). Tpx is a...; Region: PRX_Atyp2cys; cd03014 1155071003740 dimer interface [polypeptide binding]; other site 1155071003741 catalytic triad [active] 1155071003742 peroxidatic and resolving cysteines [active] 1155071003743 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 1155071003744 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1155071003745 ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254 1155071003746 Walker A/P-loop; other site 1155071003747 ATP binding site [chemical binding]; other site 1155071003748 Q-loop/lid; other site 1155071003749 ABC transporter signature motif; other site 1155071003750 Walker B; other site 1155071003751 D-loop; other site 1155071003752 H-loop/switch region; other site 1155071003753 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 1155071003754 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1155071003755 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1155071003756 Walker A/P-loop; other site 1155071003757 ATP binding site [chemical binding]; other site 1155071003758 Q-loop/lid; other site 1155071003759 ABC transporter signature motif; other site 1155071003760 Walker B; other site 1155071003761 D-loop; other site 1155071003762 H-loop/switch region; other site 1155071003763 Transcriptional regulators [Transcription]; Region: MarR; COG1846 1155071003764 MarR family; Region: MarR_2; pfam12802 1155071003765 ExsB is a transcription regulator related protein. It is a subfamily of a Adenosine nucleotide binding superfamily of proteins. This protein family is represented by a single member in nearly every completed large (> 1000 genes) prokaryotic genome. In...; Region: ExsB; cd01995 1155071003766 Ligand Binding Site [chemical binding]; other site 1155071003767 6-pyruvoyl tetrahydropterin synthase; Region: PTPS; pfam01242 1155071003768 active site 1155071003769 7-cyano-7-deazaguanosine (preQ0) biosynthesis protein QueE; Region: Bsubt_queE; TIGR03365 1155071003770 putative 7-cyano-7-deazaguanosine (preQ0) biosynthesis protein QueE; Region: rSAM_QueE_Ecoli; TIGR04322 1155071003771 7-cyano-7-deazaguanine reductase; Provisional; Region: PRK13258 1155071003772 Protein of unknown function (DUF3021); Region: DUF3021; pfam11457 1155071003773 glutamate dehydrogenase; Provisional; Region: PRK09414 1155071003774 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 1155071003775 NAD(P) binding domain of glutamate dehydrogenase, subgroup 2; Region: NAD_bind_2_Glu_DH; cd05313 1155071003776 NAD(P) binding site [chemical binding]; other site 1155071003777 KxYKxGKxW signal peptide; Region: KxYKxGKxW; TIGR03715 1155071003778 Glycosyl hydrolase family 70; Region: Glyco_hydro_70; pfam02324 1155071003779 Alpha amylase catalytic domain family; Region: AmyAc_family; cl07893 1155071003780 Alpha amylase catalytic domain family; Region: AmyAc_family; cl07893 1155071003781 glucan-binding repeat; Region: glucan_65_rpt; TIGR04035 1155071003782 glucan-binding repeat; Region: glucan_65_rpt; TIGR04035 1155071003783 glucan-binding repeat; Region: glucan_65_rpt; TIGR04035 1155071003784 glucan-binding repeat; Region: glucan_65_rpt; TIGR04035 1155071003785 glucan-binding repeat; Region: glucan_65_rpt; TIGR04035 1155071003786 Membrane transport protein; Region: Mem_trans; cl09117 1155071003787 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 1155071003788 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1155071003789 ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254 1155071003790 Walker A/P-loop; other site 1155071003791 ATP binding site [chemical binding]; other site 1155071003792 Q-loop/lid; other site 1155071003793 ABC transporter signature motif; other site 1155071003794 Walker B; other site 1155071003795 D-loop; other site 1155071003796 H-loop/switch region; other site 1155071003797 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 1155071003798 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1155071003799 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1155071003800 Walker A/P-loop; other site 1155071003801 ATP binding site [chemical binding]; other site 1155071003802 Q-loop/lid; other site 1155071003803 ABC transporter signature motif; other site 1155071003804 Walker B; other site 1155071003805 D-loop; other site 1155071003806 H-loop/switch region; other site 1155071003807 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 1155071003808 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1155071003809 Walker A/P-loop; other site 1155071003810 ATP binding site [chemical binding]; other site 1155071003811 Q-loop/lid; other site 1155071003812 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1155071003813 ABC transporter; Region: ABC_tran_2; pfam12848 1155071003814 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1155071003815 tRNA CCA-pyrophosphorylase; Provisional; Region: PRK13299 1155071003816 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 1155071003817 active site 1155071003818 NTP binding site [chemical binding]; other site 1155071003819 metal binding triad [ion binding]; metal-binding site 1155071003820 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 1155071003821 tRNA nucleotidyltransferase domain 2 putative; Region: tRNA_NucTran2_2; pfam13735 1155071003822 dihydrodipicolinate reductase; Provisional; Region: PRK00048 1155071003823 Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113 1155071003824 Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173 1155071003825 EDD domain protein, DegV family; Region: DegV; TIGR00762 1155071003826 Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645 1155071003827 Protein of unknown function (DUF1149); Region: DUF1149; pfam06619 1155071003828 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1155071003829 ABC transporter signature motif; other site 1155071003830 Walker B; other site 1155071003831 D-loop; other site 1155071003832 H-loop/switch region; other site 1155071003833 PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cd01610 1155071003834 active site 1155071003835 Beta-lactamase; Region: Beta-lactamase; pfam00144 1155071003836 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 1155071003837 UDP-glucose 4-epimerase [Cell envelope biogenesis, outer membrane]; Region: GalE; COG1087 1155071003838 UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247 1155071003839 NAD binding site [chemical binding]; other site 1155071003840 homodimer interface [polypeptide binding]; other site 1155071003841 active site 1155071003842 substrate binding site [chemical binding]; other site 1155071003843 galactose-1-phosphate uridylyltransferase; Provisional; Region: PRK05270 1155071003844 Galactose-1-phosphate uridyl transferase, N-terminal domain; Region: GalP_UDP_transf; pfam01087 1155071003845 Galactose-1-phosphate uridyl transferase, C-terminal domain; Region: GalP_UDP_tr_C; pfam02744 1155071003846 galactokinase; Provisional; Region: PRK05322 1155071003847 Galactokinase galactose-binding signature; Region: GalKase_gal_bdg; pfam10509 1155071003848 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 1155071003849 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 1155071003850 DNA-binding transcriptional repressor EbgR; Provisional; Region: PRK10339 1155071003851 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1155071003852 DNA binding site [nucleotide binding] 1155071003853 Ligand-binding domain of DNA transcription repressor GalR which is one of two regulatory proteins involved in galactose transport and metabolism; Region: PBP1_GalR; cd01544 1155071003854 putative dimerization interface [polypeptide binding]; other site 1155071003855 putative ligand binding site [chemical binding]; other site 1155071003856 alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403 1155071003857 Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333 1155071003858 Ca binding site [ion binding]; other site 1155071003859 active site 1155071003860 catalytic site [active] 1155071003861 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 1155071003862 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 1155071003863 Walker A/P-loop; other site 1155071003864 ATP binding site [chemical binding]; other site 1155071003865 Q-loop/lid; other site 1155071003866 ABC transporter signature motif; other site 1155071003867 Walker B; other site 1155071003868 D-loop; other site 1155071003869 H-loop/switch region; other site 1155071003870 TOBE domain; Region: TOBE_2; pfam08402 1155071003871 Alpha amylase catalytic domain found in sucrose phosphorylase (also called sucrose glucosyltransferase, disaccharide glucosyltransferase, and sucrose-phosphate alpha-D glucosyltransferase); Region: AmyAc_Sucrose_phosphorylase; cd11355 1155071003872 sucrose phosphorylase; Region: sucrose_gtfA; TIGR03852 1155071003873 active site 1155071003874 homodimer interface [polypeptide binding]; other site 1155071003875 catalytic site [active] 1155071003876 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 1155071003877 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1155071003878 dimer interface [polypeptide binding]; other site 1155071003879 conserved gate region; other site 1155071003880 putative PBP binding loops; other site 1155071003881 ABC-ATPase subunit interface; other site 1155071003882 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1155071003883 dimer interface [polypeptide binding]; other site 1155071003884 conserved gate region; other site 1155071003885 putative PBP binding loops; other site 1155071003886 ABC-ATPase subunit interface; other site 1155071003887 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 1155071003888 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 1155071003889 Alpha-galactosidase [Carbohydrate transport and metabolism]; Region: GalA; COG3345 1155071003890 Melibiase; Region: Melibiase; pfam02065 1155071003891 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 1155071003892 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 1155071003893 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1155071003894 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1155071003895 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 1155071003896 Transposase; Region: HTH_Tnp_1; cl17663 1155071003897 Integrase core domain; Region: rve; pfam00665 1155071003898 Integrase core domain; Region: rve_2; pfam13333 1155071003899 bifunctional homocysteine S-methyltransferase/5,10-methylenetetrahydrofolate reductase protein; Reviewed; Region: PRK08645 1155071003900 Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; cl14105 1155071003901 Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cd00537 1155071003902 FAD binding site [chemical binding]; other site 1155071003903 5-methyltetrahydropteroyltriglutamate--homocysteine S-methyltransferase; Provisional; Region: PRK05222 1155071003904 CIMS - Cobalamine-independent methonine synthase, or MetE, N-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_N_terminal_like; cd03312 1155071003905 THF binding site; other site 1155071003906 CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311 1155071003907 substrate binding site [chemical binding]; other site 1155071003908 THF binding site; other site 1155071003909 zinc-binding site [ion binding]; other site 1155071003910 PTS system 2-O-a-mannosyl-D-glycerate specific transporter subunit IIABC; Provisional; Region: PRK09765 1155071003911 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 1155071003912 active site 1155071003913 phosphorylation site [posttranslational modification] 1155071003914 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569 1155071003915 active site 1155071003916 P-loop; other site 1155071003917 phosphorylation site [posttranslational modification] 1155071003918 Phosphotransferase system, fructose-specific IIC component [Carbohydrate transport and metabolism]; Region: FruA; COG1299 1155071003919 Fructose-1-phosphate kinase and related fructose-6-phosphate kinase (PfkB) [Carbohydrate transport and metabolism]; Region: FruK; COG1105 1155071003920 1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164 1155071003921 putative substrate binding site [chemical binding]; other site 1155071003922 putative ATP binding site [chemical binding]; other site 1155071003923 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 1155071003924 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; cl17531 1155071003925 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 1155071003926 Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492 1155071003927 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1155071003928 tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026 1155071003929 16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK00122 1155071003930 RimM N-terminal domain; Region: RimM; pfam01782 1155071003931 PRC-barrel domain; Region: PRC; pfam05239 1155071003932 Predicted RNA-binding protein (contains KH domain) [General function prediction only]; Region: COG1837 1155071003933 KH domain; Region: KH_4; pfam13083 1155071003934 Ribosomal protein S16 [Translation, ribosomal structure and biogenesis]; Region: RpsP; COG0228 1155071003935 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 1155071003936 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 1155071003937 FtsX-like permease family; Region: FtsX; pfam02687 1155071003938 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 1155071003939 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 1155071003940 Walker A/P-loop; other site 1155071003941 ATP binding site [chemical binding]; other site 1155071003942 Q-loop/lid; other site 1155071003943 ABC transporter signature motif; other site 1155071003944 Walker B; other site 1155071003945 D-loop; other site 1155071003946 H-loop/switch region; other site 1155071003947 Membrane-fusion protein [Cell envelope biogenesis, outer membrane]; Region: AcrA; COG0845 1155071003948 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 1155071003949 HlyD family secretion protein; Region: HlyD_3; pfam13437 1155071003950 carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294 1155071003951 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 1155071003952 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 1155071003953 Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787 1155071003954 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 1155071003955 ATP-grasp domain; Region: ATP-grasp_4; cl17255 1155071003956 Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424 1155071003957 IMP binding site; other site 1155071003958 dimer interface [polypeptide binding]; other site 1155071003959 interdomain contacts; other site 1155071003960 partial ornithine binding site; other site 1155071003961 carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564 1155071003962 Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; smart01097 1155071003963 Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744 1155071003964 catalytic site [active] 1155071003965 subunit interface [polypeptide binding]; other site 1155071003966 aspartate carbamoyltransferase catalytic subunit; Provisional; Region: pyrB; PRK00856 1155071003967 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 1155071003968 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 1155071003969 uracil transporter; Provisional; Region: PRK10720 1155071003970 Pyrimidine operon attenuation protein/uracil phosphoribosyltransferase [Nucleotide transport and metabolism]; Region: PyrR; COG2065 1155071003971 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1155071003972 active site 1155071003973 Uncharacterized conserved protein [Function unknown]; Region: COG0398 1155071003974 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 1155071003975 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 1155071003976 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1155071003977 RNA binding surface [nucleotide binding]; other site 1155071003978 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 1155071003979 active site 1155071003980 lipoprotein signal peptidase; Provisional; Region: PRK14797 1155071003981 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1155071003982 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1155071003983 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 1155071003984 dimerization interface [polypeptide binding]; other site 1155071003985 NADH pyrophosphatase, a member of the Nudix hydrolase superfamily, catalyzes the cleavage of NADH into reduced nicotinamide mononucleotide (NMNH) and AMP. Like other members of the Nudix family, it requires a divalent cation, such as Mg2+ or Mn2+, for...; Region: NADH_pyrophosphatase; cd03429 1155071003986 putative NADH binding site [chemical binding]; other site 1155071003987 putative active site [active] 1155071003988 nudix motif; other site 1155071003989 putative metal binding site [ion binding]; other site 1155071003990 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 1155071003991 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 1155071003992 50S ribosomal protein L27; Validated; Region: rpmA; PRK05435 1155071003993 Protein of unknown function (DUF464); Region: DUF464; pfam04327 1155071003994 50S ribosomal protein L21; Validated; Region: rplU; PRK05573 1155071003995 L21_leader; Ribosomal protein L21_leader 1155071003996 Protein of unknown function (DUF1211); Region: DUF1211; pfam06736 1155071003997 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1155071003998 Coenzyme A binding pocket [chemical binding]; other site 1155071003999 Bacterial capsule synthesis protein PGA_cap; Region: PGA_cap; smart00854 1155071004000 CapA and related proteins, metallophosphatase domain; Region: MPP_CapA; cd07381 1155071004001 putative active site [active] 1155071004002 putative metal binding site [ion binding]; other site 1155071004003 thiamine biosynthesis protein ThiI; Provisional; Region: PRK01565 1155071004004 THUMP domain of thiamine biosynthesis protein ThiI; Region: THUMP_ThiI; cd11716 1155071004005 ThiI is required for thiazole synthesis in the thiamine biosynthesis pathway. It belongs to the Adenosine Nucleotide Hydrolysis suoerfamily and predicted to bind to Adenosine nucleotide; Region: ThiI; cd01712 1155071004006 Ligand Binding Site [chemical binding]; other site 1155071004007 Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104 1155071004008 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 1155071004009 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1155071004010 catalytic residue [active] 1155071004011 folylpolyglutamate synthase/dihydrofolate synthase; Region: folC; TIGR01499 1155071004012 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 1155071004013 glutathione reductase; Validated; Region: PRK06116 1155071004014 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1155071004015 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 1155071004016 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1155071004017 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1155071004018 active site 1155071004019 catalytic tetrad [active] 1155071004020 GBS Bsp-like repeat; Region: GBS_Bsp-like; pfam08481 1155071004021 GBS Bsp-like repeat; Region: GBS_Bsp-like; pfam08481 1155071004022 GBS Bsp-like repeat; Region: GBS_Bsp-like; pfam08481 1155071004023 GBS Bsp-like repeat; Region: GBS_Bsp-like; pfam08481 1155071004024 Surface antigen [General function prediction only]; Region: COG3942 1155071004025 CHAP domain; Region: CHAP; pfam05257 1155071004026 CHAP domain; Region: CHAP; pfam05257 1155071004027 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1155071004028 non-specific DNA binding site [nucleotide binding]; other site 1155071004029 salt bridge; other site 1155071004030 sequence-specific DNA binding site [nucleotide binding]; other site 1155071004031 Domain of unknown function (DUF955); Region: DUF955; pfam06114 1155071004032 CHAP domain; Region: CHAP; cl17642 1155071004033 Ricin-type beta-trefoil lectin domain-like; Region: RicinB_lectin_2; pfam14200 1155071004034 Ricin-type beta-trefoil lectin domain; Region: Ricin_B_lectin; pfam00652 1155071004035 Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific...; Region: RICIN; cd00161 1155071004036 putative sugar binding sites [chemical binding]; other site 1155071004037 Q-X-W motif; other site 1155071004038 Ricin-type beta-trefoil lectin domain; Region: Ricin_B_lectin; pfam00652 1155071004039 Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific...; Region: RICIN; cd00161 1155071004040 putative sugar binding sites [chemical binding]; other site 1155071004041 Q-X-W motif; other site 1155071004042 undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714 1155071004043 Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187 1155071004044 Ligand binding site; other site 1155071004045 Putative Catalytic site; other site 1155071004046 DXD motif; other site 1155071004047 conserved hypothetical integral membrane protein; Region: TIGR03766 1155071004048 Transmembrane subunit (TM) of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which are involved in the uptake of branched-chain amino acids (AAs), as well as TMs of transporters involved in the uptake of...; Region: TM_PBP1_branched-chain-AA_like; cl00454 1155071004049 Sulfatase; Region: Sulfatase; pfam00884 1155071004050 Rhamnan synthesis protein F; Region: RgpF; pfam05045 1155071004051 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 1155071004052 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 1155071004053 active site 1155071004054 ABC-type polysaccharide/polyol phosphate transport system, ATPase component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagH; COG1134 1155071004055 ATP-binding cassette component of polysaccharide transport system; Region: ABC_KpsT_Wzt; cd03220 1155071004056 Walker A/P-loop; other site 1155071004057 ATP binding site [chemical binding]; other site 1155071004058 Q-loop/lid; other site 1155071004059 ABC transporter signature motif; other site 1155071004060 Walker B; other site 1155071004061 D-loop; other site 1155071004062 H-loop/switch region; other site 1155071004063 ABC-type polysaccharide/polyol phosphate export systems, permease component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagG; COG1682 1155071004064 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 1155071004065 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 1155071004066 Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_d; cd04196 1155071004067 Probable Catalytic site; other site 1155071004068 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1155071004069 This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_6; cd04955 1155071004070 dTDP-6-deoxy-L-lyxo-4-hexulose reductase and related proteins, extended (e) SDRs; Region: dTDP_HR_like_SDR_e; cd05254 1155071004071 RmlD substrate binding domain; Region: RmlD_sub_bind; pfam04321 1155071004072 NADP binding site [chemical binding]; other site 1155071004073 active site 1155071004074 putative substrate binding site [chemical binding]; other site 1155071004075 undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714 1155071004076 Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187 1155071004077 Ligand binding site; other site 1155071004078 Putative Catalytic site; other site 1155071004079 DXD motif; other site 1155071004080 Predicted metal-sulfur cluster biosynthetic enzyme [General function prediction only]; Region: PaaD; COG2151 1155071004081 RNA polymerase sigma factor RpoD; Validated; Region: PRK09210 1155071004082 Sigma-70 factor, region 1.1; Region: Sigma70_r1_1; pfam03979 1155071004083 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 1155071004084 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1155071004085 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 1155071004086 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1155071004087 DNA binding residues [nucleotide binding] 1155071004088 DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275 1155071004089 DNA primase; Validated; Region: dnaG; PRK05667 1155071004090 TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364 1155071004091 active site 1155071004092 metal binding site [ion binding]; metal-binding site 1155071004093 interdomain interaction site; other site 1155071004094 large-conductance mechanosensitive channel; Reviewed; Region: mscL; PRK00567 1155071004095 Large-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscL; COG1970 1155071004096 30S ribosomal protein S21; Reviewed; Region: rpsU; PRK00270 1155071004097 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 1155071004098 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1155071004099 substrate binding pocket [chemical binding]; other site 1155071004100 membrane-bound complex binding site; other site 1155071004101 hinge residues; other site 1155071004102 transaminase; Validated; Region: PRK07324 1155071004103 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1155071004104 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1155071004105 homodimer interface [polypeptide binding]; other site 1155071004106 catalytic residue [active] 1155071004107 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 1155071004108 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1155071004109 substrate binding pocket [chemical binding]; other site 1155071004110 membrane-bound complex binding site; other site 1155071004111 hinge residues; other site 1155071004112 MutT homolog-1 (MTH1) is a member of the Nudix hydrolase superfamily. MTH1, the mammalian counterpart of MutT, hydrolyzes oxidized purine nucleoside triphosphates, such as 8-oxo-dGTP and 2-hydroxy-ATP, to monophosphates, thereby preventing the...; Region: MTH1; cd03427 1155071004113 putative active site [active] 1155071004114 nucleotide binding site [chemical binding]; other site 1155071004115 nudix motif; other site 1155071004116 putative metal binding site [ion binding]; other site 1155071004117 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1155071004118 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1155071004119 non-specific DNA binding site [nucleotide binding]; other site 1155071004120 salt bridge; other site 1155071004121 sequence-specific DNA binding site [nucleotide binding]; other site 1155071004122 excinuclease ABC subunit B; Provisional; Region: PRK05298 1155071004123 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1155071004124 ATP binding site [chemical binding]; other site 1155071004125 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1155071004126 nucleotide binding region [chemical binding]; other site 1155071004127 ATP-binding site [chemical binding]; other site 1155071004128 Ultra-violet resistance protein B; Region: UvrB; pfam12344 1155071004129 CAAX protease self-immunity; Region: Abi; pfam02517 1155071004130 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 1155071004131 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1155071004132 substrate binding pocket [chemical binding]; other site 1155071004133 membrane-bound complex binding site; other site 1155071004134 hinge residues; other site 1155071004135 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1155071004136 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 1155071004137 substrate binding pocket [chemical binding]; other site 1155071004138 membrane-bound complex binding site; other site 1155071004139 hinge residues; other site 1155071004140 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1155071004141 dimer interface [polypeptide binding]; other site 1155071004142 conserved gate region; other site 1155071004143 putative PBP binding loops; other site 1155071004144 ABC-ATPase subunit interface; other site 1155071004145 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 1155071004146 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 1155071004147 Walker A/P-loop; other site 1155071004148 ATP binding site [chemical binding]; other site 1155071004149 Q-loop/lid; other site 1155071004150 ABC transporter signature motif; other site 1155071004151 Walker B; other site 1155071004152 D-loop; other site 1155071004153 H-loop/switch region; other site 1155071004154 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 1155071004155 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1155071004156 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1155071004157 GTPase CgtA; Reviewed; Region: obgE; PRK12297 1155071004158 GTP1/OBG; Region: GTP1_OBG; pfam01018 1155071004159 Obg GTPase; Region: Obg; cd01898 1155071004160 G1 box; other site 1155071004161 GTP/Mg2+ binding site [chemical binding]; other site 1155071004162 Switch I region; other site 1155071004163 G2 box; other site 1155071004164 G3 box; other site 1155071004165 Switch II region; other site 1155071004166 G4 box; other site 1155071004167 G5 box; other site 1155071004168 Domain of unknown function (DUF1967); Region: DUF1967; pfam09269 1155071004169 Predicted thioesterase [General function prediction only]; Region: COG5496 1155071004170 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 1155071004171 triphenylmethane reductase (TMR)-like proteins, NMRa-like, atypical (a) SDRs; Region: TMR_SDR_a; cd05269 1155071004172 NADP binding site [chemical binding]; other site 1155071004173 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 1155071004174 active site 1155071004175 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629 1155071004176 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 1155071004177 CoenzymeA binding site [chemical binding]; other site 1155071004178 subunit interaction site [polypeptide binding]; other site 1155071004179 PHB binding site; other site 1155071004180 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1155071004181 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1155071004182 sequence-specific DNA binding site [nucleotide binding]; other site 1155071004183 salt bridge; other site 1155071004184 CAAX protease self-immunity; Region: Abi; pfam02517 1155071004185 SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase [Translation, ribosomal structure and biogenesis]; Region: TrmA; COG2265 1155071004186 Predicted RNA-binding protein, contains TRAM domain [General function prediction only]; Region: COG3269 1155071004187 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1155071004188 S-adenosylmethionine binding site [chemical binding]; other site 1155071004189 Transcriptional regulator [Transcription]; Region: LytR; COG1316 1155071004190 prephenate dehydratase; Provisional; Region: PRK11898 1155071004191 Prephenate dehydratase; Region: PDT; pfam00800 1155071004192 C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905 1155071004193 putative L-Phe binding site [chemical binding]; other site 1155071004194 shikimate kinase; Reviewed; Region: aroK; PRK00131 1155071004195 Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464 1155071004196 ADP binding site [chemical binding]; other site 1155071004197 magnesium binding site [ion binding]; other site 1155071004198 putative shikimate binding site; other site 1155071004199 3-phosphoshikimate 1-carboxyvinyltransferase; Provisional; Region: PRK02427 1155071004200 EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556 1155071004201 hinge; other site 1155071004202 active site 1155071004203 hypothetical protein; Provisional; Region: PRK13676 1155071004204 prephenate dehydrogenase; Validated; Region: PRK06545 1155071004205 prephenate dehydrogenase; Validated; Region: PRK08507 1155071004206 C-terminal ACT domain of the monofunctional, NAD dependent, prephenate dehydrogenase (PDH); Region: ACT_PDH-BS; cd04909 1155071004207 Chorismate synthase [Amino acid transport and metabolism]; Region: AroC; COG0082 1155071004208 Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304 1155071004209 Tetramer interface [polypeptide binding]; other site 1155071004210 active site 1155071004211 FMN-binding site [chemical binding]; other site 1155071004212 Glycerol dehydrogenase and related enzymes [Energy production and conversion]; Region: GldA; COG0371 1155071004213 Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195 1155071004214 active site 1155071004215 dimer interface [polypeptide binding]; other site 1155071004216 metal binding site [ion binding]; metal-binding site 1155071004217 shikimate 5-dehydrogenase; Reviewed; Region: aroE; PRK00258 1155071004218 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 1155071004219 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 1155071004220 NAD(P) binding site [chemical binding]; other site 1155071004221 shikimate binding site; other site 1155071004222 3-dehydroquinate dehydratase [Amino acid transport and metabolism]; Region: AroD; COG0710 1155071004223 Type I 3-dehydroquinase, (3-dehydroquinate dehydratase or DHQase); Region: DHQase_I; cd00502 1155071004224 active site 1155071004225 catalytic residue [active] 1155071004226 dimer interface [polypeptide binding]; other site 1155071004227 Predicted SAM-dependent methyltransferases [General function prediction only]; Region: COG1092 1155071004228 Middle domain of the SAM-dependent methyltransferase RlmI and related proteins; Region: RlmI_M_like; cd11572 1155071004229 putative RNA binding site [nucleotide binding]; other site 1155071004230 Phosphoglycerol transferase and related proteins, alkaline phosphatase superfamily [Cell envelope biogenesis, outer membrane]; Region: MdoB; COG1368 1155071004231 Sulfatase; Region: Sulfatase; pfam00884 1155071004232 Predicted hydrolase (HAD superfamily) [General function prediction only]; Region: COG1011 1155071004233 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1155071004234 motif II; other site 1155071004235 lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484 1155071004236 LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322 1155071004237 dimer interface [polypeptide binding]; other site 1155071004238 putative anticodon binding site; other site 1155071004239 Lys_tRNA synthetase (LysRS) class II core domain. Class II LysRS is a dimer which attaches a lysine to the 3' OH group of ribose of the appropriate tRNA. Its assignment to class II aaRS is based upon its structure and the presence of three...; Region: LysRS_core; cd00775 1155071004240 motif 1; other site 1155071004241 active site 1155071004242 motif 2; other site 1155071004243 motif 3; other site 1155071004244 Gram-positive signal peptide, YSIRK family; Region: YSIRK_signal; TIGR01168 1155071004245 glucan-binding repeat; Region: glucan_65_rpt; TIGR04035 1155071004246 Putative cell wall binding repeat; Region: CW_binding_1; pfam01473 1155071004247 glucan-binding repeat; Region: glucan_65_rpt; TIGR04035 1155071004248 Predicted peptidase [General function prediction only]; Region: COG4099 1155071004249 manganese transport protein MntH; Reviewed; Region: PRK00701 1155071004250 Natural resistance-associated macrophage protein; Region: Nramp; pfam01566 1155071004251 Uncharacterized protein conserved in bacteria (DUF2128); Region: DUF2128; pfam09901 1155071004252 alkyl hydroperoxide reductase subunit F; Provisional; Region: PRK15317 1155071004253 Alkyl hydroperoxide reductase F subunit (AhpF) N-terminal domain (NTD) family, N-terminal TRX-fold subdomain; AhpF is a homodimeric flavoenzyme which catalyzes the NADH-dependent reduction of the peroxiredoxin AhpC, which in turn catalyzes the reduction...; Region: AhpF_NTD_N; cd02974 1155071004254 catalytic residue [active] 1155071004255 TRX-GRX-like family, Alkyl hydroperoxide reductase F subunit (AhpF) N-terminal domain (NTD) subfamily, C-terminal TRX-fold subdomain; AhpF is a homodimeric flavoenzyme which catalyzes the NADH-dependent reduction of the peroxiredoxin AhpC, which then...; Region: AhpF_NTD_C; cd03026 1155071004256 catalytic residues [active] 1155071004257 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1155071004258 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1155071004259 peroxiredoxin; Region: AhpC; TIGR03137 1155071004260 Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015 1155071004261 dimer interface [polypeptide binding]; other site 1155071004262 decamer (pentamer of dimers) interface [polypeptide binding]; other site 1155071004263 catalytic triad [active] 1155071004264 peroxidatic and resolving cysteines [active] 1155071004265 Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826 1155071004266 Peptidase family U32; Region: Peptidase_U32; pfam01136 1155071004267 Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826 1155071004268 Peptidase family U32; Region: Peptidase_U32; pfam01136 1155071004269 Protein of unknown function (DUF3270); Region: DUF3270; pfam11674 1155071004270 YtxH-like protein; Region: YtxH; pfam12732 1155071004271 Uncharacterized protein containing a divergent version of the methyl-accepting chemotaxis-like domain [General function prediction only]; Region: COG4768 1155071004272 prolipoprotein diacylglyceryl transferase; Reviewed; Region: PRK12437 1155071004273 HPr kinase/phosphorylase; Provisional; Region: PRK05428 1155071004274 HPr Serine kinase N terminus; Region: Hpr_kinase_N; pfam02603 1155071004275 HprK/P, the bifunctional histidine-containing protein kinase/phosphatase, controls the phosphorylation state of the phosphocarrier protein HPr and regulates the utilization of carbon sources by gram-positive bacteria. It catalyzes both the ATP-dependent...; Region: HprK_C; cd01918 1155071004276 Hpr binding site; other site 1155071004277 active site 1155071004278 homohexamer subunit interaction site [polypeptide binding]; other site 1155071004279 PspC domain; Region: PspC; pfam04024 1155071004280 hypothetical protein; Provisional; Region: PRK04351 1155071004281 SprT homologues; Region: SprT; cl01182 1155071004282 Transcriptional accessory protein [Transcription]; Region: Tex; COG2183 1155071004283 Tex-like protein N-terminal domain; Region: Tex_N; pfam09371 1155071004284 Likely ribonuclease with RNase H fold; Region: YqgFc; smart00732 1155071004285 S1_Tex: The C-terminal S1 domain of a transcription accessory factor called Tex, which has been characterized in Bordetella pertussis and Pseudomonas aeruginosa. The tex gene is essential in Bortella pertusis and is named for its role in toxin expression; Region: S1_Tex; cd05685 1155071004286 RNA binding site [nucleotide binding]; other site 1155071004287 Predicted permeases [General function prediction only]; Region: COG0701 1155071004288 Predicted membrane protein [Function unknown]; Region: COG3689 1155071004289 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1155071004290 putative substrate translocation pore; other site 1155071004291 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1155071004292 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1155071004293 signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416 1155071004294 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 1155071004295 P loop; other site 1155071004296 GTP binding site [chemical binding]; other site 1155071004297 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1155071004298 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 1155071004299 active site 1155071004300 motif I; other site 1155071004301 motif II; other site 1155071004302 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1155071004303 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1155071004304 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 1155071004305 active site 1155071004306 motif I; other site 1155071004307 motif II; other site 1155071004308 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 1155071004309 Protein of unknown function (DUF3114); Region: DUF3114; pfam11311 1155071004310 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 1155071004311 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1155071004312 looped-hinge helix DNA binding domain, AbrB family; Region: lp_hng_hel_AbrB; TIGR01439 1155071004313 ABC-2 family transporter protein; Region: ABC2_membrane_5; pfam13346 1155071004314 gallidermin-class lantibiotic protection ABC transporter, ATP-binding subunit; Region: galliderm_ABC; TIGR03740 1155071004315 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 1155071004316 Walker A/P-loop; other site 1155071004317 ATP binding site [chemical binding]; other site 1155071004318 Q-loop/lid; other site 1155071004319 ABC transporter signature motif; other site 1155071004320 Walker B; other site 1155071004321 D-loop; other site 1155071004322 H-loop/switch region; other site 1155071004323 Regulators of stationary/sporulation gene expression [Transcription]; Region: AbrB; COG2002 1155071004324 looped-hinge helix DNA binding domain, AbrB family; Region: lp_hng_hel_AbrB; TIGR01439 1155071004325 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 1155071004326 alcohol dehydrogenase and quinone reductase-like medium chain degydrogenases/reductases; Region: MDR_like_2; cd05289 1155071004327 putative NAD(P) binding site [chemical binding]; other site 1155071004328 Helix-Turn-Helix DNA binding domain of putative transcription regulators from the MerR superfamily; Region: HTH_MerR-like_sg3; cd01282 1155071004329 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 1155071004330 DNA binding residues [nucleotide binding] 1155071004331 putative dimer interface [polypeptide binding]; other site 1155071004332 Predicted phosphohydrolases [General function prediction only]; Region: Icc; COG1409 1155071004333 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cd00838 1155071004334 active site 1155071004335 metal binding site [ion binding]; metal-binding site 1155071004336 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 1155071004337 Glycerophosphodiester phosphodiesterase domain of Thermoanaerobacter tengcongensis and similar proteins; Region: GDPD_TtGDE_like; cd08563 1155071004338 active site 1155071004339 catalytic site [active] 1155071004340 metal binding site [ion binding]; metal-binding site 1155071004341 dimer interface [polypeptide binding]; other site 1155071004342 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; smart00831 1155071004343 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 1155071004344 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 1155071004345 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 1155071004346 haloacid dehalogenase-like hydrolase; Region: HAD; pfam12710 1155071004347 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 1155071004348 yybP-ykoY; yybP-ykoY leader 1155071004349 Domain of unknown function (DUF1934); Region: DUF1934; pfam09148 1155071004350 HD superfamily phosphohydrolases [General function prediction only]; Region: COG1078 1155071004351 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1155071004352 Zn2+ binding site [ion binding]; other site 1155071004353 Mg2+ binding site [ion binding]; other site 1155071004354 sugar phosphate phosphatase; Provisional; Region: PRK10513 1155071004355 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1155071004356 active site 1155071004357 motif I; other site 1155071004358 motif II; other site 1155071004359 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1155071004360 FemAB family; Region: FemAB; pfam02388 1155071004361 FemAB family; Region: FemAB; pfam02388 1155071004362 Acetyltransferase (GNAT) domain; Region: Acetyltransf_6; cl17497 1155071004363 Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311 1155071004364 triosephosphate isomerase; Provisional; Region: PRK14565 1155071004365 substrate binding site [chemical binding]; other site 1155071004366 dimer interface [polypeptide binding]; other site 1155071004367 catalytic triad [active] 1155071004368 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 1155071004369 ATP-binding cassette domain of multidrug resistance protein-like transporters; Region: ABCC_MRP_Like; cd03228 1155071004370 Walker A/P-loop; other site 1155071004371 ATP binding site [chemical binding]; other site 1155071004372 Q-loop/lid; other site 1155071004373 ABC transporter signature motif; other site 1155071004374 Walker B; other site 1155071004375 D-loop; other site 1155071004376 H-loop/switch region; other site 1155071004377 PQQ-like domain; Region: PQQ_2; pfam13360 1155071004378 PQQ-dependent dehydrogenases and related proteins; Region: PQQ_DH_like; cl11493 1155071004379 active site 1155071004380 C1 Peptidase family (MEROPS database nomenclature), also referred to as the papain family; composed of two subfamilies of cysteine peptidases (CPs), C1A (papain) and C1B (bleomycin hydrolase). Papain-like enzymes are mostly endopeptidases with some...; Region: Peptidase_C1; cl00298 1155071004381 active site 1155071004382 elongation factor Tu; Reviewed; Region: PRK00049 1155071004383 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 1155071004384 G1 box; other site 1155071004385 GEF interaction site [polypeptide binding]; other site 1155071004386 GTP/Mg2+ binding site [chemical binding]; other site 1155071004387 Switch I region; other site 1155071004388 G2 box; other site 1155071004389 G3 box; other site 1155071004390 Switch II region; other site 1155071004391 G4 box; other site 1155071004392 G5 box; other site 1155071004393 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 1155071004394 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 1155071004395 Antibiotic Binding Site [chemical binding]; other site 1155071004396 Bacterial cell division membrane protein [Cell division and chromosome partitioning]; Region: FtsW; COG0772 1155071004397 phosphoenolpyruvate carboxylase; Reviewed; Region: PRK00009 1155071004398 Phosphoenolpyruvate carboxylase [Energy production and conversion]; Region: Ppc; COG2352 1155071004399 Inner membrane protein CreD; Region: CreD; cl01844 1155071004400 PlyB is a bacteriophage endolysin that displays potent lytic activity toward Bacillus anthracis. PlyB has an N-terminal glycosyl hydrolase family 25 (GH25) catalytic domain and a C-terminal bacterial SH3-like domain, SH3b. Both domains are required for...; Region: GH25_PlyB-like; cd06523 1155071004401 Glycosyl hydrolases family 25; Region: Glyco_hydro_25; pfam01183 1155071004402 active site 1155071004403 Thiamine transporter protein (Thia_YuaJ); Region: Thia_YuaJ; pfam09515 1155071004404 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cl02712 1155071004405 amidase catalytic site [active] 1155071004406 Zn binding residues [ion binding]; other site 1155071004407 substrate binding site [chemical binding]; other site 1155071004408 Predicted membrane protein [Function unknown]; Region: COG2035 1155071004409 This CD includes cysteinyl-tRNA(Pro) deacylases from Haemophilus influenzae and Escherichia coli and other related bacterial proteins. These trans-acting, single-domain proteins are homologs of ProX and also the cis-acting prolyl-tRNA synthetase (ProRS)...; Region: YbaK_deacylase; cd00002 1155071004410 putative deacylase active site [active] 1155071004411 hypothetical protein; Provisional; Region: PRK11770 1155071004412 Domain of unknown function (DUF307); Region: DUF307; pfam03733 1155071004413 Domain of unknown function (DUF307); Region: DUF307; pfam03733 1155071004414 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1155071004415 catalytic core [active] 1155071004416 Ribosomal protein L20; Region: Ribosomal_L20; cd07026 1155071004417 23S rRNA binding site [nucleotide binding]; other site 1155071004418 L21 binding site [polypeptide binding]; other site 1155071004419 L13 binding site [polypeptide binding]; other site 1155071004420 50S ribosomal protein L35; Reviewed; Region: rpmI; PRK00172 1155071004421 translation initiation factor IF-3; Reviewed; Region: infC; PRK00028 1155071004422 Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198 1155071004423 Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707 1155071004424 L20_leader; Ribosomal protein L20_leader 1155071004425 cytidylate kinase; Provisional; Region: cmk; PRK00023 1155071004426 AAA domain; Region: AAA_17; pfam13207 1155071004427 Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020 1155071004428 CMP-binding site; other site 1155071004429 The sites determining sugar specificity; other site 1155071004430 Ferredoxin [Energy production and conversion]; Region: Fer; COG1141 1155071004431 peptidase T; Region: peptidase-T; TIGR01882 1155071004432 M20 Peptidase T specifically cleaves tripeptides; Region: M20_peptT; cd03892 1155071004433 metal binding site [ion binding]; metal-binding site 1155071004434 dimer interface [polypeptide binding]; other site 1155071004435 GBS Bsp-like repeat; Region: GBS_Bsp-like; pfam08481 1155071004436 GBS Bsp-like repeat; Region: GBS_Bsp-like; pfam08481 1155071004437 GBS Bsp-like repeat; Region: GBS_Bsp-like; pfam08481 1155071004438 GBS Bsp-like repeat; Region: GBS_Bsp-like; pfam08481 1155071004439 GBS Bsp-like repeat; Region: GBS_Bsp-like; pfam08481 1155071004440 GBS Bsp-like repeat; Region: GBS_Bsp-like; pfam08481 1155071004441 Endo-N-acetylmuramidases (muramidases) are lysozymes (also referred to as peptidoglycan hydrolases) that degrade bacterial cell walls by catalyzing the hydrolysis of 1,4-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues; Region: GH25_muramidase; cl10448 1155071004442 Glycosyl hydrolases family 25; Region: Glyco_hydro_25; pfam01183 1155071004443 active site 1155071004444 Flagellin N-methylase; Region: FliB; pfam03692 1155071004445 Uncharacterized homolog of gamma-carboxymuconolactone decarboxylase subunit [Function unknown]; Region: COG0599 1155071004446 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1155071004447 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1155071004448 active site 1155071004449 catalytic tetrad [active] 1155071004450 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1155071004451 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1155071004452 active site 1155071004453 catalytic tetrad [active] 1155071004454 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 1155071004455 Helix-Turn-Helix DNA binding domain of the MerR-like transcription regulators YyaN and YraB; Region: HTH_YyaN; cd01109 1155071004456 DNA binding residues [nucleotide binding] 1155071004457 putative dimer interface [polypeptide binding]; other site 1155071004458 NADP+-dependent non-phosphorylating glyceraldehyde 3-phosphate dehydrogenase and ALDH family 11; Region: ALDH_F11_NP-GAPDH; cd07082 1155071004459 NADP-dependent glyceraldehyde-3-phosphate dehydrogenase; Provisional; Region: PLN00412 1155071004460 tetrameric interface [polypeptide binding]; other site 1155071004461 activator binding site; other site 1155071004462 NADP binding site [chemical binding]; other site 1155071004463 substrate binding site [chemical binding]; other site 1155071004464 catalytic residues [active] 1155071004465 Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism]; Region: PtsA; COG1080 1155071004466 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 1155071004467 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 1155071004468 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 1155071004469 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 1155071004470 dimerization domain swap beta strand [polypeptide binding]; other site 1155071004471 regulatory protein interface [polypeptide binding]; other site 1155071004472 active site 1155071004473 regulatory phosphorylation site [posttranslational modification]; other site 1155071004474 Predicted membrane protein [Function unknown]; Region: COG4905 1155071004475 Protein of unknown function (DUF1113); Region: DUF1113; pfam06541 1155071004476 Isocitrate/isopropylmalate dehydrogenase; Region: Iso_dh; cl00445 1155071004477 isocitrate dehydrogenase; Validated; Region: PRK06451 1155071004478 Bacillus subtilis (Bs) citrate synthase (CS)-II_like. CS catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the citric acid cycle (TCA or Krebs cycle). 2MCS catalyzes the...; Region: BSuCS-II_like; cd06110 1155071004479 dimer interface [polypeptide binding]; other site 1155071004480 Citrate synthase; Region: Citrate_synt; pfam00285 1155071004481 active site 1155071004482 citrylCoA binding site [chemical binding]; other site 1155071004483 oxalacetate/citrate binding site [chemical binding]; other site 1155071004484 coenzyme A binding site [chemical binding]; other site 1155071004485 catalytic triad [active] 1155071004486 aconitate hydratase; Validated; Region: PRK09277 1155071004487 Aconitase A catalytic domain; Region: AcnA_IRP; cd01586 1155071004488 substrate binding site [chemical binding]; other site 1155071004489 ligand binding site [chemical binding]; other site 1155071004490 Aconitase A swivel domain. This is the major form of the TCA cycle enzyme aconitate hydratase, also known as aconitase and citrate hydro-lyase. It includes bacterial and archaeal aconitase A, and the eukaryotic cytosolic form of aconitase. This group...; Region: AcnA_IRP_Swivel; cd01580 1155071004491 substrate binding site [chemical binding]; other site 1155071004492 NrdH-redoxin (NrdH) family; NrdH is a small monomeric protein with a conserved redox active CXXC motif within a TRX fold, characterized by a glutaredoxin (GRX)-like sequence and TRX-like activity profile. In vitro, it displays protein disulfide reductase...; Region: NrdH; cd02976 1155071004493 catalytic residues [active] 1155071004494 ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK07306 1155071004495 Ribonucleotide reductase N-terminal; Region: RNR_N; pfam08343 1155071004496 Class I ribonucleotide reductase; Region: RNR_I; cd01679 1155071004497 active site 1155071004498 dimer interface [polypeptide binding]; other site 1155071004499 catalytic residues [active] 1155071004500 effector binding site; other site 1155071004501 R2 peptide binding site; other site 1155071004502 ribonucleotide-diphosphate reductase subunit beta; Provisional; Region: nrdF2; PRK13966 1155071004503 Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049 1155071004504 dimer interface [polypeptide binding]; other site 1155071004505 putative radical transfer pathway; other site 1155071004506 diiron center [ion binding]; other site 1155071004507 tyrosyl radical; other site 1155071004508 acetylornithine aminotransferase; Provisional; Region: PRK04260 1155071004509 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 1155071004510 inhibitor-cofactor binding pocket; inhibition site 1155071004511 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1155071004512 catalytic residue [active] 1155071004513 AAK_NAGK-like: N-Acetyl-L-glutamate kinase (NAGK)-like . Included in this CD are the Escherichia coli and Pseudomonas aeruginosa type NAGKs which catalyze the phosphorylation of N-acetyl-L-glutamate (NAG) by ATP in the second step of arginine...; Region: AAK_NAGK-like; cd04238 1155071004514 nucleotide binding site [chemical binding]; other site 1155071004515 N-acetyl-L-glutamate binding site [chemical binding]; other site 1155071004516 Ornithine acetyltransferase (OAT) family; also referred to as ArgJ. OAT catalyzes the first and fifth steps in arginine biosynthesis, coupling acetylation of glutamate with deacetylation of N-acetylornithine, which allows recycling of the acetyl group in...; Region: OAT; cd02152 1155071004517 heterotetramer interface [polypeptide binding]; other site 1155071004518 active site pocket [active] 1155071004519 cleavage site 1155071004520 N-acetyl-gamma-glutamyl-phosphate reductase; Validated; Region: argC; PRK00436 1155071004521 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 1155071004522 CAAX protease self-immunity; Region: Abi; pfam02517 1155071004523 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1155071004524 non-specific DNA binding site [nucleotide binding]; other site 1155071004525 salt bridge; other site 1155071004526 sequence-specific DNA binding site [nucleotide binding]; other site 1155071004527 Transposase; Region: DEDD_Tnp_IS110; pfam01548 1155071004528 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 1155071004529 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 1155071004530 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 1155071004531 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1155071004532 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 1155071004533 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1155071004534 dimer interface [polypeptide binding]; other site 1155071004535 phosphorylation site [posttranslational modification] 1155071004536 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1155071004537 ATP binding site [chemical binding]; other site 1155071004538 Mg2+ binding site [ion binding]; other site 1155071004539 G-X-G motif; other site 1155071004540 proteobacterial dedicated sortase system response regulator; Region: marine_sort_RR; TIGR03787 1155071004541 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1155071004542 active site 1155071004543 phosphorylation site [posttranslational modification] 1155071004544 intermolecular recognition site; other site 1155071004545 dimerization interface [polypeptide binding]; other site 1155071004546 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1155071004547 DNA binding site [nucleotide binding] 1155071004548 TraX protein; Region: TraX; cl05434 1155071004549 lantibiotic protection ABC transporter permease subunit, MutG family; Region: lanti_perm_MutG; TIGR03733 1155071004550 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 1155071004551 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1155071004552 dimer interface [polypeptide binding]; other site 1155071004553 conserved gate region; other site 1155071004554 putative PBP binding loops; other site 1155071004555 ABC-ATPase subunit interface; other site 1155071004556 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 1155071004557 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 1155071004558 Walker A/P-loop; other site 1155071004559 ATP binding site [chemical binding]; other site 1155071004560 Q-loop/lid; other site 1155071004561 ABC transporter signature motif; other site 1155071004562 Walker B; other site 1155071004563 D-loop; other site 1155071004564 H-loop/switch region; other site 1155071004565 NMT1-like family; Region: NMT1_2; pfam13379 1155071004566 NMT1/THI5 like; Region: NMT1; pfam09084 1155071004567 substrate binding pocket [chemical binding]; other site 1155071004568 membrane-bound complex binding site; other site 1155071004569 alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252 1155071004570 Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673 1155071004571 motif 1; other site 1155071004572 active site 1155071004573 motif 2; other site 1155071004574 motif 3; other site 1155071004575 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 1155071004576 DHHA1 domain; Region: DHHA1; pfam02272 1155071004577 Tubby C 2; Region: Tub_2; cl02043 1155071004578 foldase protein PrsA; Reviewed; Region: prsA; PRK01326 1155071004579 SurA N-terminal domain; Region: SurA_N; pfam09312 1155071004580 PPIC-type PPIASE domain; Region: Rotamase_2; pfam13145 1155071004581 Predicted O-methyltransferase [General function prediction only]; Region: COG4122 1155071004582 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1155071004583 S-adenosylmethionine binding site [chemical binding]; other site 1155071004584 Haloacid dehalogenase-like hydrolase; Region: HAD_2; pfam13419 1155071004585 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1155071004586 motif II; other site 1155071004587 Oligoendopeptidase F [Amino acid transport and metabolism]; Region: COG1164 1155071004588 Peptidase family M3B Oligopeptidase F (PepF); Region: M3B_PepF_3; cd09608 1155071004589 active site 1155071004590 Zn binding site [ion binding]; other site 1155071004591 Competence protein CoiA-like family; Region: CoiA; pfam06054 1155071004592 Esterase/lipase [Lipid metabolism]; Region: Aes; COG0657 1155071004593 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 1155071004594 Calcium/calmodulin dependent protein kinase II Association; Region: CaMKII_AD; cl17504 1155071004595 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 1155071004596 Zeta-crystallin with NADP-dependent quinone reductase activity (QOR); Region: zeta_crystallin; cd08253 1155071004597 NAD(P) binding site [chemical binding]; other site 1155071004598 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 1155071004599 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1155071004600 DNA-binding site [nucleotide binding]; DNA binding site 1155071004601 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1155071004602 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1155071004603 homodimer interface [polypeptide binding]; other site 1155071004604 catalytic residue [active] 1155071004605 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1155071004606 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 1155071004607 Coenzyme A binding pocket [chemical binding]; other site 1155071004608 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 1155071004609 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1155071004610 RNA binding surface [nucleotide binding]; other site 1155071004611 Pseudouridine synthase, Escherichia coli RsuA like; Region: PseudoU_synth_RsuA; cd02553 1155071004612 active site 1155071004613 uracil binding [chemical binding]; other site 1155071004614 C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cl02776 1155071004615 N-terminal domain interface [polypeptide binding]; other site 1155071004616 dimer interface [polypeptide binding]; other site 1155071004617 substrate binding pocket (H-site) [chemical binding]; other site 1155071004618 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363 1155071004619 GlcN6P_deaminase: Glucosamine-6-phosphate (GlcN6P) deaminase subfamily; GlcN6P deaminase catalyzes the reversible conversion of GlcN6P to D-fructose-6-phosphate (Fru6P) and ammonium. The reaction is an aldo-keto isomerization coupled with an amination or...; Region: GlcN6P_deaminase; cd01399 1155071004620 active site 1155071004621 trimer interface [polypeptide binding]; other site 1155071004622 allosteric site; other site 1155071004623 active site lid [active] 1155071004624 hexamer (dimer of trimers) interface [polypeptide binding]; other site 1155071004625 Nodulin-21 and CCC1-related protein family; Region: Nodulin-21_like_1; cd02432 1155071004626 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Provisional; Region: queA; PRK00147 1155071004627 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Region: queA; TIGR00113 1155071004628 Acyl-CoA thioester hydrolase/BAAT N-terminal region; Region: Bile_Hydr_Trans; pfam04775 1155071004629 Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412 1155071004630 BAAT / Acyl-CoA thioester hydrolase C terminal; Region: BAAT_C; pfam08840 1155071004631 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1155071004632 MarR family; Region: MarR_2; pfam12802 1155071004633 Putative membrane peptidase family (DUF2324); Region: DUF2324; pfam10086 1155071004634 Beta-lactamase enzyme family; Region: Beta-lactamase2; pfam13354 1155071004635 Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605 1155071004636 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 1155071004637 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 1155071004638 DNA polymerase III subunit delta; Reviewed; Region: holA; PRK05574 1155071004639 DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144 1155071004640 Protein of unknown function (DUF805); Region: DUF805; cl01224 1155071004641 Predicted membrane metal-binding protein [General function prediction only]; Region: ComEC; COG0658 1155071004642 Domain of unknown function (DUF4131); Region: DUF4131; pfam13567 1155071004643 Telomere length regulation protein; Region: Telomere_reg-2; pfam10193 1155071004644 Competence protein; Region: Competence; pfam03772 1155071004645 Predicted hydrolase (metallo-beta-lactamase superfamily) [General function prediction only]; Region: ComEC; COG2333 1155071004646 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 1155071004647 SLBB domain; Region: SLBB; pfam10531 1155071004648 comEA protein; Region: comE; TIGR01259 1155071004649 Helix-hairpin-helix motif; Region: HHH; pfam00633 1155071004650 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 1155071004651 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 1155071004652 putative acyl-acceptor binding pocket; other site 1155071004653 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 1155071004654 Catalytic NodB homology domain of Streptococcus mutans polysaccharide deacetylase PgdA, Bacillus subtilis YheN, and similar proteins; Region: CE4_SmPgdA_like; cd10944 1155071004655 NodB motif; other site 1155071004656 active site 1155071004657 catalytic site [active] 1155071004658 Zn binding site [ion binding]; other site 1155071004659 Protein of unknown function with HXXEE motif; Region: HXXEE; pfam13787 1155071004660 Predicted O-methyltransferase [General function prediction only]; Region: COG4123 1155071004661 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1155071004662 S-adenosylmethionine binding site [chemical binding]; other site 1155071004663 The GIY-YIG domain of uncharacterized protein family UPF0213 related to structure-specific endonuclease SLX1; Region: GIY-YIG_UPF0213; cd10456 1155071004664 GIY-YIG motif/motif A; other site 1155071004665 putative active site [active] 1155071004666 putative metal binding site [ion binding]; other site 1155071004667 ATP-dependent RNA helicase SrmB; Provisional; Region: PRK11192 1155071004668 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 1155071004669 ATP binding site [chemical binding]; other site 1155071004670 Mg++ binding site [ion binding]; other site 1155071004671 motif III; other site 1155071004672 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1155071004673 nucleotide binding region [chemical binding]; other site 1155071004674 ATP-binding site [chemical binding]; other site 1155071004675 putative cross-wall-targeting lipoprotein signal; Region: strep_RK_lipo; TIGR03726 1155071004676 Streptococcal surface antigen repeat; Region: Strep_SA_rep; pfam06696 1155071004677 Streptococcal surface antigen repeat; Region: Strep_SA_rep; pfam06696 1155071004678 Glucan-binding protein C; Region: GbpC; pfam08363 1155071004679 adhesin isopeptide-forming domain, sspB-C2 type; Region: isopep_sspB_C2; TIGR04228 1155071004680 Gram positive anchor; Region: Gram_pos_anchor; pfam00746 1155071004681 Gram-positive signal peptide, YSIRK family; Region: YSIRK_signal; TIGR01168 1155071004682 Bacterial SH3 domain; Region: SH3_5; pfam08460 1155071004683 Bacterial SH3 domain; Region: SH3_5; pfam08460 1155071004684 GBS Bsp-like repeat; Region: GBS_Bsp-like; pfam08481 1155071004685 GBS Bsp-like repeat; Region: GBS_Bsp-like; pfam08481 1155071004686 Bacterial SH3 domain; Region: SH3_5; pfam08460 1155071004687 peptide chain release factor 3; Provisional; Region: prfC; PRK00741 1155071004688 Release Factor 3 (RF3) protein involved in the terminal step of translocation in bacteria; Region: RF3; cd04169 1155071004689 G1 box; other site 1155071004690 putative GEF interaction site [polypeptide binding]; other site 1155071004691 GTP/Mg2+ binding site [chemical binding]; other site 1155071004692 Switch I region; other site 1155071004693 G2 box; other site 1155071004694 G3 box; other site 1155071004695 Switch II region; other site 1155071004696 G4 box; other site 1155071004697 G5 box; other site 1155071004698 RF3_II: this subfamily represents the domain II of bacterial Release Factor 3 (RF3). Termination of protein synthesis by the ribosome requires two release factor (RF) classes. The class II RF3 is a GTPase that removes class I RFs (RF1 or RF2) from the...; Region: RF3_II; cd03689 1155071004699 Integral membrane protein (intg_mem_TP0381); Region: Intg_mem_TP0381; pfam09529 1155071004700 TIR domain; Region: TIR_2; pfam13676 1155071004701 UDP-N-acetylmuramyl pentapeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurF; COG0770 1155071004702 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 1155071004703 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 1155071004704 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 1155071004705 Predicted Na+-dependent transporter [General function prediction only]; Region: COG0385 1155071004706 Sodium Bile acid symporter family; Region: SBF; cl17470 1155071004707 THF; Tetrahydrofolate riboswitch 1155071004708 ECF-type riboflavin transporter, S component; Region: ECF-ribofla_trS; cl17272 1155071004709 D-alanyl-alanine synthetase A; Reviewed; Region: ddl; PRK01966 1155071004710 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 1155071004711 D-ala D-ala ligase C-terminus; Region: Dala_Dala_lig_C; pfam07478 1155071004712 recombination protein RecR; Reviewed; Region: recR; PRK00076 1155071004713 RecR protein; Region: RecR; pfam02132 1155071004714 TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR. RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025 1155071004715 putative active site [active] 1155071004716 putative metal-binding site [ion binding]; other site 1155071004717 tetramer interface [polypeptide binding]; other site 1155071004718 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 1155071004719 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 1155071004720 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 1155071004721 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1155071004722 catalytic core [active] 1155071004723 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1155071004724 dihydroorotate dehydrogenase (subfamily 1) family protein; Region: pyrD_sub1_fam; TIGR01037 1155071004725 Dihydroorotate dehydrogenase (DHOD) class 1A FMN-binding domain. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine...; Region: DHOD_1A_like; cd04741 1155071004726 active site 1155071004727 FMN binding site [chemical binding]; other site 1155071004728 substrate binding site [chemical binding]; other site 1155071004729 catalytic residues [active] 1155071004730 homodimer interface [polypeptide binding]; other site 1155071004731 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 1155071004732 metal binding site 2 [ion binding]; metal-binding site 1155071004733 putative DNA binding helix; other site 1155071004734 metal binding site 1 [ion binding]; metal-binding site 1155071004735 dimer interface [polypeptide binding]; other site 1155071004736 structural Zn2+ binding site [ion binding]; other site 1155071004737 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1155071004738 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1155071004739 hypothetical protein; Provisional; Region: PRK14851 1155071004740 Integrase core domain; Region: rve_3; cl15866 1155071004741 Transposase; Region: DEDD_Tnp_IS110; pfam01548 1155071004742 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 1155071004743 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 1155071004744 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 1155071004745 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 1155071004746 IHF dimer interface [polypeptide binding]; other site 1155071004747 IHF - DNA interface [nucleotide binding]; other site 1155071004748 Uncharacterized protein conserved in bacteria (DUF2140); Region: DUF2140; pfam09911 1155071004749 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053 1155071004750 active site 1155071004751 catalytic triad [active] 1155071004752 oxyanion hole [active] 1155071004753 EDD domain protein, DegV family; Region: DegV; TIGR00762 1155071004754 Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645 1155071004755 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: RecN; COG0497 1155071004756 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 1155071004757 Walker A/P-loop; other site 1155071004758 ATP binding site [chemical binding]; other site 1155071004759 Q-loop/lid; other site 1155071004760 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 1155071004761 ABC transporter signature motif; other site 1155071004762 Walker B; other site 1155071004763 D-loop; other site 1155071004764 H-loop/switch region; other site 1155071004765 Arginine repressor, DNA binding domain; Region: Arg_repressor; pfam01316 1155071004766 Arginine repressor, C-terminal domain; Region: Arg_repressor_C; pfam02863 1155071004767 Predicted rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: COG1189 1155071004768 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1155071004769 RNA binding surface [nucleotide binding]; other site 1155071004770 FtsJ-like methyltransferase; Region: FtsJ; pfam01728 1155071004771 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 1155071004772 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 1155071004773 substrate binding pocket [chemical binding]; other site 1155071004774 chain length determination region; other site 1155071004775 substrate-Mg2+ binding site; other site 1155071004776 catalytic residues [active] 1155071004777 aspartate-rich region 1; other site 1155071004778 active site lid residues [active] 1155071004779 aspartate-rich region 2; other site 1155071004780 exodeoxyribonuclease VII small subunit; Provisional; Region: PRK00977 1155071004781 exodeoxyribonuclease VII large subunit; Reviewed; Region: xseA; PRK00286 1155071004782 ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489 1155071004783 generic binding surface II; other site 1155071004784 generic binding surface I; other site 1155071004785 Putative regulator of cell autolysis [Signal transduction mechanisms]; Region: LytS; COG3275 1155071004786 5TMR of 5TMR-LYT; Region: 5TM-5TMR_LYT; pfam07694 1155071004787 GAF domain; Region: GAF_3; pfam13492 1155071004788 Histidine kinase; Region: His_kinase; pfam06580 1155071004789 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1155071004790 ATP binding site [chemical binding]; other site 1155071004791 Mg2+ binding site [ion binding]; other site 1155071004792 G-X-G motif; other site 1155071004793 two-component response regulator; Provisional; Region: PRK14084 1155071004794 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1155071004795 active site 1155071004796 phosphorylation site [posttranslational modification] 1155071004797 intermolecular recognition site; other site 1155071004798 dimerization interface [polypeptide binding]; other site 1155071004799 LytTr DNA-binding domain; Region: LytTR; pfam04397 1155071004800 LrgA family; Region: LrgA; cl00608 1155071004801 LrgB-like family; Region: LrgB; cl00596 1155071004802 B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171 1155071004803 putative substrate binding site [chemical binding]; other site 1155071004804 putative ATP binding site [chemical binding]; other site 1155071004805 bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK14179 1155071004806 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763 1155071004807 NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080 1155071004808 homodimer interface [polypeptide binding]; other site 1155071004809 NADP binding site [chemical binding]; other site 1155071004810 substrate binding site [chemical binding]; other site 1155071004811 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 1155071004812 classical (c) SDRs; Region: SDR_c; cd05233 1155071004813 NAD(P) binding site [chemical binding]; other site 1155071004814 active site 1155071004815 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846 1155071004816 glyceraldehyde-3-phosphate dehydrogenase, type I; Region: GAPDH-I; TIGR01534 1155071004817 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 1155071004818 S-ribosylhomocysteinase; Provisional; Region: PRK02260 1155071004819 S-Ribosylhomocysteinase (LuxS); Region: LuxS; cl00802 1155071004820 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 1155071004821 Predicted transcriptional regulator [Transcription]; Region: COG1959 1155071004822 Transcriptional regulator; Region: Rrf2; pfam02082 1155071004823 B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171 1155071004824 putative substrate binding site [chemical binding]; other site 1155071004825 putative ATP binding site [chemical binding]; other site 1155071004826 bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK14179 1155071004827 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763 1155071004828 NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080 1155071004829 homodimer interface [polypeptide binding]; other site 1155071004830 NADP binding site [chemical binding]; other site 1155071004831 substrate binding site [chemical binding]; other site 1155071004832 Fe2+ transport system protein B [Inorganic ion transport and metabolism]; Region: FeoB; COG0370 1155071004833 Ferrous iron transport protein B (FeoB) family; Region: FeoB; cd01879 1155071004834 G1 box; other site 1155071004835 GTP/Mg2+ binding site [chemical binding]; other site 1155071004836 Switch I region; other site 1155071004837 G2 box; other site 1155071004838 G3 box; other site 1155071004839 Switch II region; other site 1155071004840 G4 box; other site 1155071004841 G5 box; other site 1155071004842 Nucleoside recognition; Region: Gate; pfam07670 1155071004843 Ferrous iron transport protein B C terminus; Region: FeoB_C; pfam07664 1155071004844 Nucleoside recognition; Region: Gate; pfam07670 1155071004845 FeoA domain; Region: FeoA; pfam04023 1155071004846 Fe2+ transport system protein A [Inorganic ion transport and metabolism]; Region: FeoA; COG1918 1155071004847 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 1155071004848 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 1155071004849 Walker A/P-loop; other site 1155071004850 ATP binding site [chemical binding]; other site 1155071004851 Q-loop/lid; other site 1155071004852 ABC transporter signature motif; other site 1155071004853 Walker B; other site 1155071004854 D-loop; other site 1155071004855 H-loop/switch region; other site 1155071004856 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 1155071004857 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1155071004858 dimer interface [polypeptide binding]; other site 1155071004859 conserved gate region; other site 1155071004860 putative PBP binding loops; other site 1155071004861 ABC-ATPase subunit interface; other site 1155071004862 Protein of unknown function (DUF1797); Region: DUF1797; cl11550 1155071004863 ornithine carbamoyltransferase; Validated; Region: PRK02102 1155071004864 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 1155071004865 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 1155071004866 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1155071004867 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 1155071004868 Walker A motif; other site 1155071004869 ATP binding site [chemical binding]; other site 1155071004870 Walker B motif; other site 1155071004871 arginine finger; other site 1155071004872 UvrB/uvrC motif; Region: UVR; pfam02151 1155071004873 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1155071004874 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 1155071004875 Walker A motif; other site 1155071004876 ATP binding site [chemical binding]; other site 1155071004877 Walker B motif; other site 1155071004878 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 1155071004879 Contains a crystal structure of the Nudix hydrolase from Enterococcus faecalis, which has an unknown function. In general, members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes...; Region: Nudix_Hydrolase_25; cd04684 1155071004880 nudix motif; other site 1155071004881 Domain of unknown function (DUF1827); Region: DUF1827; pfam08860 1155071004882 isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK05743 1155071004883 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 1155071004884 active site 1155071004885 HIGH motif; other site 1155071004886 nucleotide binding site [chemical binding]; other site 1155071004887 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 1155071004888 active site 1155071004889 KMSKS motif; other site 1155071004890 Anticodon-binding domain of bacterial and eukaryotic mitochondrial isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_BEm; cd07960 1155071004891 tRNA binding surface [nucleotide binding]; other site 1155071004892 anticodon binding site; other site 1155071004893 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 1155071004894 T-box; T-box leader 1155071004895 DivIVA protein; Region: DivIVA; pfam05103 1155071004896 DivIVA domain; Region: DivI1A_domain; TIGR03544 1155071004897 Uncharacterized conserved protein, contains S4-like domain [Function unknown]; Region: COG2302 1155071004898 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1155071004899 RNA binding surface [nucleotide binding]; other site 1155071004900 YGGT family; Region: YGGT; pfam02325 1155071004901 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1799 1155071004902 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, YBL036c-like proteins; Region: PLPDE_III_YBL036c_like; cd00635 1155071004903 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 1155071004904 catalytic residue [active] 1155071004905 cell division protein FtsZ; Validated; Region: PRK09330 1155071004906 FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes. FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201 1155071004907 nucleotide binding site [chemical binding]; other site 1155071004908 SulA interaction site; other site 1155071004909 Cell division ATPase FtsA [Cell division and chromosome partitioning]; Region: ftsA; COG0849 1155071004910 Cell division protein FtsA; Region: FtsA; smart00842 1155071004911 Cell division protein FtsA; Region: FtsA; pfam14450 1155071004912 Domain of unknown function (DUF3484); Region: DUF3484; pfam11983 1155071004913 POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478 1155071004914 Cell division protein FtsQ; Region: FtsQ; pfam03799 1155071004915 undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726 1155071004916 MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785 1155071004917 active site 1155071004918 homodimer interface [polypeptide binding]; other site 1155071004919 UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK02472 1155071004920 Alanine dehydrogenase/PNT, C-terminal domain; Region: AlaDh_PNT_C; smart01002 1155071004921 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 1155071004922 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 1155071004923 Protein of unknown function (DUF3165); Region: DUF3165; pfam11364 1155071004924 Predicted membrane GTPase involved in stress response [Signal transduction mechanisms]; Region: TypA; COG1217 1155071004925 Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891 1155071004926 G1 box; other site 1155071004927 putative GEF interaction site [polypeptide binding]; other site 1155071004928 GTP/Mg2+ binding site [chemical binding]; other site 1155071004929 Switch I region; other site 1155071004930 G2 box; other site 1155071004931 G3 box; other site 1155071004932 Switch II region; other site 1155071004933 G4 box; other site 1155071004934 G5 box; other site 1155071004935 BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu. BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691 1155071004936 BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants. BipA is a highly...; Region: BipA_TypA_C; cd03710 1155071004937 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 1155071004938 active site residue [active] 1155071004939 ROK family protein (putative glucokinase); Region: ROK_glcA_fam; TIGR00744 1155071004940 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 1155071004941 nucleotide binding site [chemical binding]; other site 1155071004942 Bacterial protein of unknown function (DUF910); Region: DUF910; pfam06014 1155071004943 DNA-binding ferritin-like protein (oxidative damage protectant) [Inorganic ion transport and metabolism]; Region: Dps; COG0783 1155071004944 DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043 1155071004945 dimerization interface [polypeptide binding]; other site 1155071004946 DPS ferroxidase diiron center [ion binding]; other site 1155071004947 ion pore; other site 1155071004948 Type II secretory pathway, prepilin signal peptidase PulO and related peptidases [Cell motility and secretion / Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: PulO; COG1989 1155071004949 Bacterial Peptidase A24 N-terminal domain; Region: DiS_P_DiS; pfam06750 1155071004950 tryptophan synthase alpha subunit; Provisional; Region: trpA; CHL00200 1155071004951 Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724 1155071004952 substrate binding site [chemical binding]; other site 1155071004953 active site 1155071004954 catalytic residues [active] 1155071004955 heterodimer interface [polypeptide binding]; other site 1155071004956 tryptophan synthase, beta subunit; Region: trpB; TIGR00263 1155071004957 Tryptophan synthase-beta: Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446 1155071004958 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1155071004959 catalytic residue [active] 1155071004960 Phosphoribosylanthranilate isomerase (PRAI) catalyzes the fourth step of the tryptophan biosynthesis, the conversion of N-(5'- phosphoribosyl)-anthranilate (PRA) to 1-(o-carboxyphenylamino)- 1-deoxyribulose 5-phosphate (CdRP). Most PRAIs are...; Region: PRAI; cd00405 1155071004961 active site 1155071004962 Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331 1155071004963 active site 1155071004964 ribulose/triose binding site [chemical binding]; other site 1155071004965 phosphate binding site [ion binding]; other site 1155071004966 substrate (anthranilate) binding pocket [chemical binding]; other site 1155071004967 product (indole) binding pocket [chemical binding]; other site 1155071004968 anthranilate phosphoribosyltransferase; Provisional; Region: trpD; PRK00188 1155071004969 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 1155071004970 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 1155071004971 para-aminobenzoate synthase component II; Provisional; Region: PRK08857 1155071004972 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 1155071004973 glutamine binding [chemical binding]; other site 1155071004974 catalytic triad [active] 1155071004975 anthranilate synthase component I; Provisional; Region: PRK13570 1155071004976 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 1155071004977 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 1155071004978 Chorismate mutase type II; Region: CM_2; smart00830 1155071004979 T-box; T-box leader 1155071004980 Protein of unknown function (DUF975); Region: DUF975; pfam06161 1155071004981 Uncharacterized conserved protein [Function unknown]; Region: COG1359 1155071004982 Uncharacterized conserved protein related to dihydrodipicolinate reductase [Function unknown]; Region: COG3804 1155071004983 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 1155071004984 Helix-Turn-Helix DNA binding domain of the BmrR transcription regulator; Region: HTH_BmrR; cd01107 1155071004985 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 1155071004986 DNA binding residues [nucleotide binding] 1155071004987 drug binding residues [chemical binding]; other site 1155071004988 dimer interface [polypeptide binding]; other site 1155071004989 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 1155071004990 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1155071004991 ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254 1155071004992 Walker A/P-loop; other site 1155071004993 ATP binding site [chemical binding]; other site 1155071004994 Q-loop/lid; other site 1155071004995 ABC transporter signature motif; other site 1155071004996 Walker B; other site 1155071004997 D-loop; other site 1155071004998 H-loop/switch region; other site 1155071004999 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1155071005000 putative multidrug transporter membrane\ATP-binding components; Provisional; Region: PRK10789 1155071005001 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1155071005002 Walker A/P-loop; other site 1155071005003 ATP binding site [chemical binding]; other site 1155071005004 Q-loop/lid; other site 1155071005005 ABC transporter signature motif; other site 1155071005006 Walker B; other site 1155071005007 D-loop; other site 1155071005008 H-loop/switch region; other site 1155071005009 ribosomal RNA large subunit methyltransferase N; Provisional; Region: PRK14455 1155071005010 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1155071005011 FeS/SAM binding site; other site 1155071005012 Protein of unknown function (DUF1027); Region: DUF1027; pfam06265 1155071005013 Escherichia coli UshA-like family, N-terminal metallophosphatase domain; Region: MPP_UshA_N_like; cd00845 1155071005014 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 1155071005015 active site 1155071005016 metal binding site [ion binding]; metal-binding site 1155071005017 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 1155071005018 Predicted secreted protein containing a PDZ domain [Signal transduction mechanisms]; Region: SdrC; COG3480 1155071005019 PDZ domain, also called DHR (Dlg homologous region) or GLGF (after a conserved sequence motif). Many PDZ domains bind C-terminal polypeptides, though binding to internal (non-C-terminal) polypeptides and even to lipids has been demonstrated; Region: PDZ; cl00117 1155071005020 protein binding site [polypeptide binding]; other site 1155071005021 phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168 1155071005022 Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163 1155071005023 active site 1155071005024 (T/H)XGH motif; other site 1155071005025 Conserved hypothetical protein 95; Region: Cons_hypoth95; pfam03602 1155071005026 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1155071005027 S-adenosylmethionine binding site [chemical binding]; other site 1155071005028 myosin-cross-reactive antigen; Provisional; Region: PRK13977 1155071005029 probable dihydroxyacetone kinase regulator; Region: DHAK_reg; TIGR02366 1155071005030 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1155071005031 Predicted O-methyltransferase [General function prediction only]; Region: COG4123 1155071005032 AAA domain; Region: AAA_33; pfam13671 1155071005033 Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947 1155071005034 intersubunit interface [polypeptide binding]; other site 1155071005035 active site 1155071005036 zinc binding site [ion binding]; other site 1155071005037 Na+ binding site [ion binding]; other site 1155071005038 PTS system ascorbate-specific transporter subunit IIC; Reviewed; Region: PRK12997 1155071005039 PTS_IIB_ascorbate: subunit IIB of enzyme II (EII) of the L-ascorbate-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is an L-ascorbate-specific permease with two cytoplasmic subunits (IIA and IIB) and a...; Region: PTS_IIB_ascorbate; cd05563 1155071005040 active site 1155071005041 P-loop; other site 1155071005042 phosphorylation site [posttranslational modification] 1155071005043 Transcriptional antiterminator [Transcription]; Region: BglG; COG3711 1155071005044 PRD domain; Region: PRD; pfam00874 1155071005045 PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568 1155071005046 active site 1155071005047 P-loop; other site 1155071005048 phosphorylation site [posttranslational modification] 1155071005049 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 1155071005050 active site 1155071005051 phosphorylation site [posttranslational modification] 1155071005052 Protein of unknown function (DUF419); Region: DUF419; cl15265 1155071005053 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1155071005054 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 1155071005055 active site 1155071005056 motif I; other site 1155071005057 motif II; other site 1155071005058 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1155071005059 motif II; other site 1155071005060 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 1155071005061 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 1155071005062 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 1155071005063 DpnII restriction endonuclease; Region: DpnII; pfam04556 1155071005064 DNA modification methylase [DNA replication, recombination, and repair]; Region: COG0863 1155071005065 DNA methylase; Region: N6_N4_Mtase; pfam01555 1155071005066 DNA adenine methylase (dam); Region: dam; TIGR00571 1155071005067 Predicted membrane protein [Function unknown]; Region: COG4640 1155071005068 RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552 1155071005069 30S subunit binding site; other site 1155071005070 Predicted amidophosphoribosyltransferases [General function prediction only]; Region: ComFC; COG1040 1155071005071 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1155071005072 active site 1155071005073 Superfamily II DNA/RNA helicase required for DNA uptake (late competence protein) [DNA replication, recombination, and repair]; Region: comFA; COG4098 1155071005074 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1155071005075 ATP binding site [chemical binding]; other site 1155071005076 putative Mg++ binding site [ion binding]; other site 1155071005077 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1155071005078 nucleotide binding region [chemical binding]; other site 1155071005079 ATP-binding site [chemical binding]; other site 1155071005080 Uncharacterized conserved protein [Function unknown]; Region: COG1739 1155071005081 Uncharacterized protein family UPF0029; Region: UPF0029; pfam01205 1155071005082 Domain of unknown function (DUF1949); Region: DUF1949; pfam09186 1155071005083 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 1155071005084 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 1155071005085 dimer interface [polypeptide binding]; other site 1155071005086 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1155071005087 catalytic residue [active] 1155071005088 Glycerol dehydrogenase and related enzymes [Energy production and conversion]; Region: GldA; COG0371 1155071005089 Glycerol dehydrogenases (GlyDH) catalyzes oxidation of glycerol to dihydroxyacetone in glycerol dissmilation; Region: GlyDH; cd08170 1155071005090 dimer interface [polypeptide binding]; other site 1155071005091 active site 1155071005092 metal binding site [ion binding]; metal-binding site 1155071005093 Transaldolase-like fructose-6-phosphate aldolases (FSA) found in bacteria and archaea; Region: Transaldolase_FSA; cd00956 1155071005094 active site 1155071005095 intersubunit interactions; other site 1155071005096 catalytic residue [active] 1155071005097 Pyruvate-formate lyase [Energy production and conversion]; Region: PflD; COG1882 1155071005098 Pyruvate formate lyase 2 and related enzymes; Region: PFL2_DhaB_BssA; cd01677 1155071005099 dimer interface [polypeptide binding]; other site 1155071005100 active site 1155071005101 glycine loop; other site 1155071005102 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 1155071005103 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 1155071005104 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 1155071005105 glycyl-radical enzyme activating protein family; Region: PFLE_PFLC; TIGR02494 1155071005106 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1155071005107 FeS/SAM binding site; other site 1155071005108 Predicted RNA binding protein (contains ribosomal protein S1 domain) [Translation, ribosomal structure and biogenesis]; Region: VacB; COG1098 1155071005109 hypothetical protein; Provisional; Region: PRK07252 1155071005110 RNA binding site [nucleotide binding]; other site 1155071005111 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1155071005112 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 1155071005113 active site 1155071005114 motif I; other site 1155071005115 motif II; other site 1155071005116 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 1155071005117 Peptidyl-prolyl cis-trans isomerase (rotamase) - cyclophilin family [Posttranslational modification, protein turnover, chaperones]; Region: PpiB; COG0652 1155071005118 active site 1155071005119 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1155071005120 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1155071005121 active site 1155071005122 phosphorylation site [posttranslational modification] 1155071005123 intermolecular recognition site; other site 1155071005124 dimerization interface [polypeptide binding]; other site 1155071005125 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1155071005126 DNA binding residues [nucleotide binding] 1155071005127 dimerization interface [polypeptide binding]; other site 1155071005128 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 1155071005129 Histidine kinase; Region: HisKA_3; pfam07730 1155071005130 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 1155071005131 ATP binding site [chemical binding]; other site 1155071005132 Mg2+ binding site [ion binding]; other site 1155071005133 G-X-G motif; other site 1155071005134 Predicted membrane protein [Function unknown]; Region: COG4758 1155071005135 Cell wall-active antibiotics response protein (DUF2154); Region: DUF2154; pfam09922 1155071005136 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 1155071005137 Catalytic domain of Protein Kinases; Region: PKc; cd00180 1155071005138 active site 1155071005139 ATP binding site [chemical binding]; other site 1155071005140 substrate binding site [chemical binding]; other site 1155071005141 activation loop (A-loop); other site 1155071005142 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2815 1155071005143 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 1155071005144 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 1155071005145 PASTA domain; Region: PASTA; pfam03793 1155071005146 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143 1155071005147 active site 1155071005148 16S rRNA methyltransferase B; Provisional; Region: PRK14902 1155071005149 NusB family; Region: NusB; pfam01029 1155071005150 putative RNA binding site [nucleotide binding]; other site 1155071005151 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1155071005152 S-adenosylmethionine binding site [chemical binding]; other site 1155071005153 methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005 1155071005154 Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646 1155071005155 putative active site [active] 1155071005156 substrate binding site [chemical binding]; other site 1155071005157 putative cosubstrate binding site; other site 1155071005158 catalytic site [active] 1155071005159 C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704 1155071005160 substrate binding site [chemical binding]; other site 1155071005161 Primosomal protein N' (replication factor Y) - superfamily II helicase [DNA replication, recombination, and repair]; Region: PriA; COG1198 1155071005162 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1155071005163 ATP binding site [chemical binding]; other site 1155071005164 putative Mg++ binding site [ion binding]; other site 1155071005165 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1155071005166 nucleotide binding region [chemical binding]; other site 1155071005167 ATP-binding site [chemical binding]; other site 1155071005168 DNA-directed RNA polymerase subunit omega; Reviewed; Region: rpoZ; PRK00392 1155071005169 Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194 1155071005170 Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071 1155071005171 catalytic site [active] 1155071005172 G-X2-G-X-G-K; other site 1155071005173 hypothetical protein; Provisional; Region: PRK00106 1155071005174 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1155071005175 Zn2+ binding site [ion binding]; other site 1155071005176 Mg2+ binding site [ion binding]; other site 1155071005177 S-ribosylhomocysteinase; Provisional; Region: PRK02260 1155071005178 Predicted N6-adenine-specific DNA methylase [DNA replication, recombination, and repair]; Region: COG0116 1155071005179 THUMP domain associated with S-adenosylmethionine-dependent methyltransferases; Region: THUMP_AdoMetMT; cd11715 1155071005180 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 1155071005181 cell division protein GpsB; Provisional; Region: PRK14127 1155071005182 DivIVA domain; Region: DivI1A_domain; TIGR03544 1155071005183 hypothetical protein; Provisional; Region: PRK13660 1155071005184 Holliday junction-specific endonuclease; Reviewed; Region: recU; PRK02234 1155071005185 Transglycosylase; Region: Transgly; pfam00912 1155071005186 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 1155071005187 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 1155071005188 Peptidase C1B subfamily (MEROPS database nomenclature); composed of eukaryotic bleomycin hydrolases (BH) and bacterial aminopeptidases C (pepC). The proteins of this subfamily contain a large insert relative to the C1A peptidase (papain) subfamily. BH is...; Region: Peptidase_C1B; cd00585 1155071005189 trimer interface [polypeptide binding]; other site 1155071005190 active site 1155071005191 G bulge; other site 1155071005192 NAD synthase [Coenzyme metabolism]; Region: NadE; COG0171 1155071005193 NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553 1155071005194 homodimer interface [polypeptide binding]; other site 1155071005195 NAD binding pocket [chemical binding]; other site 1155071005196 ATP binding pocket [chemical binding]; other site 1155071005197 Mg binding site [ion binding]; other site 1155071005198 active-site loop [active] 1155071005199 nicotinate phosphoribosyltransferase; Validated; Region: PRK09243 1155071005200 Nicotinate phosphoribosyltransferase (NAPRTase), subgroup A. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting, reaction...; Region: NAPRTase_A; cd01570 1155071005201 active site 1155071005202 thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292 1155071005203 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1155071005204 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1155071005205 Protein of unknown function (DUF4059); Region: DUF4059; pfam13268 1155071005206 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 1155071005207 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 1155071005208 Walker A/P-loop; other site 1155071005209 ATP binding site [chemical binding]; other site 1155071005210 Q-loop/lid; other site 1155071005211 ABC transporter signature motif; other site 1155071005212 Walker B; other site 1155071005213 D-loop; other site 1155071005214 H-loop/switch region; other site 1155071005215 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 1155071005216 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1155071005217 dimer interface [polypeptide binding]; other site 1155071005218 conserved gate region; other site 1155071005219 putative PBP binding loops; other site 1155071005220 ABC-ATPase subunit interface; other site 1155071005221 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1155071005222 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 1155071005223 substrate binding pocket [chemical binding]; other site 1155071005224 membrane-bound complex binding site; other site 1155071005225 hinge residues; other site 1155071005226 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 1155071005227 DEAD-like helicases superfamily; Region: DEXDc; smart00487 1155071005228 ATP binding site [chemical binding]; other site 1155071005229 Mg++ binding site [ion binding]; other site 1155071005230 motif III; other site 1155071005231 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1155071005232 nucleotide binding region [chemical binding]; other site 1155071005233 ATP-binding site [chemical binding]; other site 1155071005234 phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108 1155071005235 Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852 1155071005236 Mg++ binding site [ion binding]; other site 1155071005237 putative catalytic motif [active] 1155071005238 putative substrate binding site [chemical binding]; other site 1155071005239 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 1155071005240 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 1155071005241 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 1155071005242 PASTA domain of PBP2x-like proteins, first repeat. Penicillin-binding proteins (PBPs) are the major targets for beta-lactam antibiotics, like penicillins and cephalosporins. Beta-lactam antibiotics specifically inhibit transpeptidase activity by...; Region: PASTA_Pbp2x-like_1; cd06576 1155071005243 PASTA domain of PBP2x-like proteins, second repeat. Penicillin-binding proteins (PBPs) are the major targets for beta-lactam antibiotics, like penicillins and cephalosporins. Beta-lactam antibiotics specifically inhibit transpeptidase activity by...; Region: PASTA_Pbp2x-like_2; cd06575 1155071005244 Protein required for the initiation of cell division [Cell division and chromosome partitioning]; Region: FtsL; COG4839 1155071005245 MraW methylase family; Region: Methyltransf_5; pfam01795 1155071005246 16S rRNA m(4)C1402 methyltranserfase; Provisional; Region: PRK00050 1155071005247 Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079 1155071005248 gamma-glutamyl phosphate reductase; Region: proA; TIGR00407 1155071005249 putative catalytic cysteine [active] 1155071005250 Glutamate 5-kinase [Amino acid transport and metabolism]; Region: ProB; COG0263 1155071005251 AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242 1155071005252 nucleotide binding site [chemical binding]; other site 1155071005253 homotetrameric interface [polypeptide binding]; other site 1155071005254 putative phosphate binding site [ion binding]; other site 1155071005255 putative allosteric binding site; other site 1155071005256 Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413 1155071005257 hypothetical protein; Provisional; Region: PRK02539 1155071005258 glycyl-tRNA synthetase subunit beta; Validated; Region: glyS; PRK01233 1155071005259 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; smart00471 1155071005260 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 1155071005261 Class II Glycyl-tRNA synthetase (GlyRS) alpha subunit core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes and in arabidopsis. It is responsible for the...; Region: GlyRS_alpha_core; cd00733 1155071005262 dimer interface [polypeptide binding]; other site 1155071005263 motif 1; other site 1155071005264 active site 1155071005265 motif 2; other site 1155071005266 motif 3; other site 1155071005267 hypothetical protein; Provisional; Region: PRK02268 1155071005268 Transcriptional regulators [Transcription]; Region: MarR; COG1846 1155071005269 MarR family; Region: MarR; pfam01047 1155071005270 MarR family; Region: MarR_2; cl17246 1155071005271 Ligand-binding SRPBCC domain of Streptococcus mutans Smu.440 and related proteins; Region: SRPBCC_Smu440-like; cd08862 1155071005272 putative hydrophobic ligand binding site [chemical binding]; other site 1155071005273 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1155071005274 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1155071005275 BadF/BadG/BcrA/BcrD ATPase family; Region: BcrAD_BadFG; cl17271 1155071005276 Activator of 2-hydroxyglutaryl-CoA dehydratase (HSP70-class ATPase domain) [Lipid metabolism]; Region: COG1924 1155071005277 BadF/BadG/BcrA/BcrD ATPase family; Region: BcrAD_BadFG; cl17271 1155071005278 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3580 1155071005279 2-hydroxyglutaryl-CoA dehydratase, D-component; Region: HGD-D; pfam06050 1155071005280 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3581 1155071005281 N-acetylglucosamine-6-phosphate deacetylase [Carbohydrate transport and metabolism]; Region: NagA; COG1820 1155071005282 N-acetylglucosamine-6-phosphate deacetylase, NagA, catalyzes the hydrolysis of the N-acetyl group of N-acetyl-glucosamine-6-phosphate (GlcNAc-6-P) to glucosamine 6-phosphate and acetate. This is the first committed step in the biosynthetic pathway to...; Region: NagA; cd00854 1155071005283 active site 1155071005284 dimer interface [polypeptide binding]; other site 1155071005285 Protein of unknown function (DUF3021); Region: DUF3021; pfam11457 1155071005286 LytTr DNA-binding domain; Region: LytTR; pfam04397 1155071005287 ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698 1155071005288 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 1155071005289 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 1155071005290 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1155071005291 Walker A/P-loop; other site 1155071005292 ATP binding site [chemical binding]; other site 1155071005293 Q-loop/lid; other site 1155071005294 ABC transporter signature motif; other site 1155071005295 Walker B; other site 1155071005296 D-loop; other site 1155071005297 H-loop/switch region; other site 1155071005298 Domain of unknown function (DUF4162); Region: DUF4162; pfam13732 1155071005299 Bacterial inner membrane protein; Region: Imp-YgjV; pfam10688 1155071005300 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1155071005301 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 1155071005302 active site 1155071005303 motif I; other site 1155071005304 motif II; other site 1155071005305 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1155071005306 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cl00207 1155071005307 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 1155071005308 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 1155071005309 metal-binding site [ion binding] 1155071005310 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 1155071005311 Soluble P-type ATPase [General function prediction only]; Region: COG4087 1155071005312 copper transport repressor, CopY/TcrY family; Region: CopY_TcrY; TIGR02698 1155071005313 Penicillinase repressor; Region: Pencillinase_R; pfam03965 1155071005314 ribosome-binding factor A; Validated; Region: rbfA; PRK00521 1155071005315 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 1155071005316 translation initiation factor IF-2; Region: IF-2; TIGR00487 1155071005317 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 1155071005318 Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887 1155071005319 G1 box; other site 1155071005320 putative GEF interaction site [polypeptide binding]; other site 1155071005321 GTP/Mg2+ binding site [chemical binding]; other site 1155071005322 Switch I region; other site 1155071005323 G2 box; other site 1155071005324 G3 box; other site 1155071005325 Switch II region; other site 1155071005326 G4 box; other site 1155071005327 G5 box; other site 1155071005328 This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702 1155071005329 Translation-initiation factor 2; Region: IF-2; pfam11987 1155071005330 mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692 1155071005331 hypothetical protein; Provisional; Region: PRK07283 1155071005332 Ylxr homologs; group of conserved hypothetical bacterial proteins of unknown function; structure revealed putative RNA binding cleft; proteins are encoded by an operon that includes other proteins involved in transcription and/or translation; Region: YlxR; cd00279 1155071005333 putative RNA binding cleft [nucleotide binding]; other site 1155071005334 transcription elongation factor NusA; Provisional; Region: nusA; PRK12327 1155071005335 NusA N-terminal domain; Region: NusA_N; pfam08529 1155071005336 S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455 1155071005337 RNA binding site [nucleotide binding]; other site 1155071005338 homodimer interface [polypeptide binding]; other site 1155071005339 NusA-like KH domain; Region: KH_5; pfam13184 1155071005340 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 1155071005341 G-X-X-G motif; other site 1155071005342 ribosome maturation protein RimP; Reviewed; Region: PRK00092 1155071005343 Bacillus subtilis YxlS-like, C-terminal domain; Region: YlxS_C; cd01734 1155071005344 putative oligomer interface [polypeptide binding]; other site 1155071005345 putative RNA binding site [nucleotide binding]; other site 1155071005346 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1155071005347 S-adenosylmethionine binding site [chemical binding]; other site 1155071005348 Thiamine kinase and related kinases [Coenzyme transport and metabolism]; Region: ycfN; COG0510 1155071005349 Phosphotransferase enzyme family; Region: APH; pfam01636 1155071005350 substrate binding site [chemical binding]; other site 1155071005351 Bacterial ABC transporter protein EcsB; Region: EcsB; cl11542 1155071005352 Bacterial ABC transporter protein EcsB; Region: EcsB; pfam05975 1155071005353 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 1155071005354 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 1155071005355 Walker A/P-loop; other site 1155071005356 ATP binding site [chemical binding]; other site 1155071005357 Q-loop/lid; other site 1155071005358 ABC transporter signature motif; other site 1155071005359 Walker B; other site 1155071005360 D-loop; other site 1155071005361 H-loop/switch region; other site 1155071005362 HINT (histidine triad nucleotide-binding protein) subgroup: Members of this CD belong to the superfamily of histidine triad hydrolases that act on alpha-phosphate of ribonucleotides. This subgroup includes members from all three forms of cellular life; Region: HINT_subgroup; cd01277 1155071005363 HIT family signature motif; other site 1155071005364 catalytic residue [active] 1155071005365 Transcriptional regulator [Transcription]; Region: LytR; COG1316 1155071005366 Predicted ATPase or kinase [General function prediction only]; Region: COG0802 1155071005367 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 1155071005368 Protein of unknown function (DUF1361); Region: DUF1361; pfam07099 1155071005369 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 1155071005370 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1155071005371 active site 1155071005372 motif I; other site 1155071005373 motif II; other site 1155071005374 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1155071005375 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1155071005376 non-specific DNA binding site [nucleotide binding]; other site 1155071005377 salt bridge; other site 1155071005378 sequence-specific DNA binding site [nucleotide binding]; other site 1155071005379 DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586 1155071005380 active site 1155071005381 DNA polymerase IV; Validated; Region: PRK02406 1155071005382 DNA binding site [nucleotide binding] 1155071005383 formate acetyltransferase 1; Region: pyr_form_ly_1; TIGR01255 1155071005384 Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939 1155071005385 Acetyltransferase (GNAT) domain; Region: Acetyltransf_5; pfam13444 1155071005386 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1155071005387 Coenzyme A binding pocket [chemical binding]; other site 1155071005388 Beta-lactamase; Region: Beta-lactamase; pfam00144 1155071005389 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 1155071005390 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 1155071005391 Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cd00333 1155071005392 amphipathic channel; other site 1155071005393 Asn-Pro-Ala signature motifs; other site 1155071005394 x-prolyl-dipeptidyl aminopeptidase; Provisional; Region: PRK05371 1155071005395 X-Prolyl dipeptidyl aminopeptidase PepX, N-terminal; Region: PepX_N; pfam09168 1155071005396 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 1155071005397 X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain; Region: PepX_C; pfam08530 1155071005398 Domain of unknown function (DUF955); Region: DUF955; cl01076 1155071005399 DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061 1155071005400 Origin of replication binding protein; Region: Herpes_ori_bp; pfam02399 1155071005401 Adenine specific DNA methylase Mod [DNA replication, recombination, and repair]; Region: COG2189 1155071005402 DNA methylase; Region: N6_N4_Mtase; pfam01555 1155071005403 DNA methylase; Region: N6_N4_Mtase; cl17433 1155071005404 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 1155071005405 DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674 1155071005406 Plasmid replication protein; Region: Rep_2; pfam01719 1155071005407 Domain of unknown function (DUF3173); Region: DUF3173; pfam11372 1155071005408 integrase; Provisional; Region: int; PHA02601 1155071005409 phiLC3 phage and phage-related integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes various bacterial (mainly gram positive) and phage integrases, including those similar to Lactococcus...; Region: INT_phiLC3_C; cd01189 1155071005410 Int/Topo IB signature motif; other site 1155071005411 hypothetical protein; Validated; Region: PRK00153 1155071005412 Protein of unknown function, DUF536; Region: DUF536; pfam04394 1155071005413 HI0933-like protein; Region: HI0933_like; pfam03486 1155071005414 yjdF; yjdF RNA motif 1155071005415 Protein of unknown function (DUF2992); Region: DUF2992; pfam11208 1155071005416 Predicted membrane protein [Function unknown]; Region: COG4392 1155071005417 Predicted branched-chain amino acid permease (azaleucine resistance) [Amino acid transport and metabolism]; Region: AzlC; COG1296 1155071005418 UGMP family protein; Validated; Region: PRK09604 1155071005419 Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214; cl17884 1155071005420 Carbamoyltransferase; Region: CmcH_NodU; pfam02543 1155071005421 ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575 1155071005422 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1155071005423 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 1155071005424 Coenzyme A binding pocket [chemical binding]; other site 1155071005425 tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725 1155071005426 Glycoprotease family; Region: Peptidase_M22; pfam00814 1155071005427 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1155071005428 MarR family; Region: MarR_2; pfam12802 1155071005429 hopanoid-associated sugar epimerase; Region: HpnA; TIGR03466 1155071005430 uncharacterized subgroup of aldehyde reductase and flavonoid reductase related proteins, extended (e) SDRs; Region: AR_FR_like_1_SDR_e; cd05228 1155071005431 putative NADP binding site [chemical binding]; other site 1155071005432 putative substrate binding site [chemical binding]; other site 1155071005433 active site 1155071005434 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1155071005435 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1155071005436 active site 1155071005437 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 1155071005438 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 1155071005439 Walker A/P-loop; other site 1155071005440 ATP binding site [chemical binding]; other site 1155071005441 Q-loop/lid; other site 1155071005442 ABC transporter signature motif; other site 1155071005443 Walker B; other site 1155071005444 D-loop; other site 1155071005445 H-loop/switch region; other site 1155071005446 hypothetical protein; Provisional; Region: PRK13667 1155071005447 mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595 1155071005448 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 1155071005449 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 1155071005450 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1155071005451 Surface antigen [General function prediction only]; Region: COG3942 1155071005452 CHAP domain; Region: CHAP; pfam05257 1155071005453 glutamate synthase subunit beta; Reviewed; Region: gltD; PRK12810 1155071005454 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 1155071005455 glutamate synthase subunit alpha; Provisional; Region: gltB; PRK11750 1155071005456 Glutamine amidotransferases class-II (Gn-AT), glutamate synthase (GltS)-type. GltS is a homodimer that synthesizes L-glutamate from 2-oxoglutarate and L-glutamine, an important step in ammonia assimilation in bacteria, cyanobacteria and plants. The...; Region: GltS; cd00713 1155071005457 active site 1155071005458 dimer interface [polypeptide binding]; other site 1155071005459 Glutamate synthase central domain; Region: Glu_syn_central; pfam04898 1155071005460 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808 1155071005461 active site 1155071005462 FMN binding site [chemical binding]; other site 1155071005463 substrate binding site [chemical binding]; other site 1155071005464 3Fe-4S cluster binding site [ion binding]; other site 1155071005465 gltb_C. This domain is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS). GltS encodes a complex iron-sulfur flavoprotein that catalyzes the synthesis of L-glutamate from L-glutamine and 2-oxoglutarate. It requires the...; Region: gltB_C; cd00982 1155071005466 domain interface; other site 1155071005467 Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174 1155071005468 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 1155071005469 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 1155071005470 Helix-Turn-Helix DNA binding domain of GlnR-like transcription regulators; Region: HTH_GlnR-like; cd01105 1155071005471 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 1155071005472 DNA binding residues [nucleotide binding] 1155071005473 putative dimer interface [polypeptide binding]; other site 1155071005474 Predicted membrane protein [Function unknown]; Region: COG4129 1155071005475 phosphoglycerate kinase; Provisional; Region: pgk; PRK00073 1155071005476 Phosphoglycerate kinase; Region: PGK; pfam00162 1155071005477 substrate binding site [chemical binding]; other site 1155071005478 hinge regions; other site 1155071005479 ADP binding site [chemical binding]; other site 1155071005480 catalytic site [active] 1155071005481 Glyceraldehyde-3-phosphate dehydrogenase/erythrose-4-phosphate dehydrogenase [Carbohydrate transport and metabolism]; Region: GapA; COG0057 1155071005482 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846 1155071005483 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 1155071005484 elongation factor G; Reviewed; Region: PRK00007 1155071005485 Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886 1155071005486 G1 box; other site 1155071005487 putative GEF interaction site [polypeptide binding]; other site 1155071005488 GTP/Mg2+ binding site [chemical binding]; other site 1155071005489 Switch I region; other site 1155071005490 G2 box; other site 1155071005491 G3 box; other site 1155071005492 Switch II region; other site 1155071005493 G4 box; other site 1155071005494 G5 box; other site 1155071005495 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 1155071005496 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 1155071005497 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 1155071005498 30S ribosomal protein S7; Validated; Region: PRK05302 1155071005499 S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368 1155071005500 S17 interaction site [polypeptide binding]; other site 1155071005501 S8 interaction site; other site 1155071005502 16S rRNA interaction site [nucleotide binding]; other site 1155071005503 streptomycin interaction site [chemical binding]; other site 1155071005504 23S rRNA interaction site [nucleotide binding]; other site 1155071005505 aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site 1155071005506 pur operon repressor; Provisional; Region: PRK09213 1155071005507 Bacterial purine repressor, N-terminal; Region: PuR_N; pfam09182 1155071005508 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1155071005509 active site 1155071005510 Predicted HD-superfamily hydrolase [General function prediction only]; Region: COG3481 1155071005511 YhaM_OBF_like: A subfamily of OB folds similar to that found in Bacillus subtilis YhaM and Staphylococcus aureus cmp-binding factor-1 (SaCBF1). Both these proteins are 3'-to-5'exoribonucleases. YhaM requires Mn2+ or Co2+ for activity and is...; Region: YhaM_OBF_like; cd04492 1155071005512 generic binding surface II; other site 1155071005513 generic binding surface I; other site 1155071005514 integrating conjugative element relaxase, PFL_4751 family; Region: ICE_TraI_Pfluor; TIGR03760 1155071005515 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1155071005516 Zn2+ binding site [ion binding]; other site 1155071005517 Mg2+ binding site [ion binding]; other site 1155071005518 Predicted nuclease of restriction endonuclease-like fold, RmuC family [General function prediction only]; Region: COG1322 1155071005519 RmuC family; Region: RmuC; pfam02646 1155071005520 Thiamine pyrophosphokinase [Coenzyme metabolism]; Region: THI80; COG1564 1155071005521 Thiamine pyrophosphokinase; Region: TPK; cd07995 1155071005522 active site 1155071005523 dimerization interface [polypeptide binding]; other site 1155071005524 thiamine binding site [chemical binding]; other site 1155071005525 Pentose-5-phosphate-3-epimerase [Carbohydrate transport and metabolism]; Region: Rpe; COG0036 1155071005526 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 1155071005527 substrate binding site [chemical binding]; other site 1155071005528 hexamer interface [polypeptide binding]; other site 1155071005529 metal binding site [ion binding]; metal-binding site 1155071005530 GTPase RsgA; Reviewed; Region: PRK00098 1155071005531 S1_YloQ_GTPase: YloQ GTase family (also known as YjeQ and CpgA), S1-like RNA-binding domain. Proteins in the YloQ GTase family bind the ribosome and have GTPase activity. The precise role of this family is unknown. The protein structure is composed of...; Region: S1_YloQ_GTPase; cd04466 1155071005532 RNA binding site [nucleotide binding]; other site 1155071005533 homodimer interface [polypeptide binding]; other site 1155071005534 Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854 1155071005535 GTPase/Zn-binding domain interface [polypeptide binding]; other site 1155071005536 GTP/Mg2+ binding site [chemical binding]; other site 1155071005537 G4 box; other site 1155071005538 G1 box; other site 1155071005539 Switch I region; other site 1155071005540 G2 box; other site 1155071005541 G3 box; other site 1155071005542 Switch II region; other site 1155071005543 16S ribosomal RNA methyltransferase KsgA/Dim1 family protein; Reviewed; Region: ksgA; PRK00274 1155071005544 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1155071005545 S-adenosylmethionine binding site [chemical binding]; other site 1155071005546 ribonuclease M5; Region: 5S_RNA_mat_M5; TIGR00334 1155071005547 TOPRIM_ RNase M5_like: The topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain found in Ribonuclease M5: (RNase M5) and other small primase-like proteins from bacteria and archaea. RNase M5 catalyzes the maturation of 5S rRNA in low...; Region: TOPRIM_RNase_M5_like; cd01027 1155071005548 putative active site [active] 1155071005549 putative metal binding site [ion binding]; other site 1155071005550 Domain of unknown function (DUF4093); Region: DUF4093; pfam13331 1155071005551 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 1155071005552 active site 1155071005553 Ribosomal protein L34; Region: Ribosomal_L34; cl00370 1155071005554 Protein of unknown function (DUF998); Region: DUF998; pfam06197 1155071005555 Predicted RNA-binding protein [General function prediction only]; Region: Jag; COG1847 1155071005556 jag_K homology RNA-binding domain. The KH domain is found in proteins homologous to the Bacillus subtilis protein Jag, which is associated with SpoIIIJ and is necessary for the third stage of sporulation. The KH motif is a beta-alpha-alpha-beta-beta...; Region: jag_KH; cd02414 1155071005557 G-X-X-G motif; other site 1155071005558 R3H domain found in proteins homologous to Bacillus subtilus Jag, which is associated with SpoIIIJ. SpoIIIJ is necessary for the third stage of sporulation. The name of the R3H domain comes from the characteristic spacing of the most conserved arginine...; Region: R3H_jag; cd02644 1155071005559 RxxxH motif; other site 1155071005560 Preprotein translocase subunit YidC [Intracellular trafficking and secretion]; Region: YidC; COG0706 1155071005561 membrane protein insertase, YidC/Oxa1 family, C-terminal domain; Region: yidC_oxa1_cterm; TIGR03592 1155071005562 ribonuclease P; Reviewed; Region: rnpA; PRK00499 1155071005563 argininosuccinate lyase; Provisional; Region: PRK00855 1155071005564 Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359 1155071005565 active sites [active] 1155071005566 tetramer interface [polypeptide binding]; other site 1155071005567 argininosuccinate synthase; Provisional; Region: PRK13820 1155071005568 Argininosuccinate synthase. The Argininosuccinate synthase is a urea cycle enzyme that catalyzes the penultimate step in arginine biosynthesis: the ATP-dependent ligation of citrulline to aspartate to form argininosuccinate, AMP and pyrophosphate . In...; Region: Argininosuccinate_Synthase; cd01999 1155071005569 ANP binding site [chemical binding]; other site 1155071005570 Substrate Binding Site II [chemical binding]; other site 1155071005571 Substrate Binding Site I [chemical binding]; other site 1155071005572 Predicted membrane protein (DUF2232); Region: DUF2232; cl01728 1155071005573 Predicted small molecule binding protein (contains 3H domain) [General function prediction only]; Region: COG1827 1155071005574 HTH domain; Region: HTH_11; pfam08279 1155071005575 3H domain; Region: 3H; pfam02829 1155071005576 glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406 1155071005577 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 1155071005578 active site 1155071005579 HIGH motif; other site 1155071005580 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 1155071005581 active site 1155071005582 KMSKS motif; other site 1155071005583 Uncharacterized conserved protein [Function unknown]; Region: COG2013 1155071005584 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeD; cd03379 1155071005585 active site clefts [active] 1155071005586 zinc binding site [ion binding]; other site 1155071005587 dimer interface [polypeptide binding]; other site 1155071005588 DNA repair protein RadA; Provisional; Region: PRK11823 1155071005589 Sms (bacterial radA) DNA repair protein. This protein is not related to archael radA any more than is to other RecA-like NTPases. Sms has a role in recombination and recombinational repair and is responsible for the stabilization or processing of...; Region: Sms; cd01121 1155071005590 Walker A motif/ATP binding site; other site 1155071005591 ATP binding site [chemical binding]; other site 1155071005592 Walker B motif; other site 1155071005593 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 1155071005594 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 1155071005595 catalytic triad [active] 1155071005596 conserved cis-peptide bond; other site 1155071005597 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 1155071005598 trimer interface [polypeptide binding]; other site 1155071005599 active site 1155071005600 NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094 1155071005601 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 1155071005602 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479 1155071005603 Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541 1155071005604 dTDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: RfbA; COG1209 1155071005605 active site 1155071005606 tetramer interface; other site 1155071005607 Rhomboid family; Region: Rhomboid; pfam01694 1155071005608 5-formyltetrahydrofolate cyclo-ligase family; Region: 5-FTHF_cyc-lig; pfam01812 1155071005609 5,10-methenyltetrahydrofolate synthetase; Region: MTHFS_bact; TIGR02727 1155071005610 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 1155071005611 M20 Peptidase Aminoacyclase-1 YkuR-like proteins, including YkuR and Ama/HipO/HyuC proteins; Region: M20_Acy1_YkuR_like; cd05670 1155071005612 metal binding site [ion binding]; metal-binding site 1155071005613 putative dimer interface [polypeptide binding]; other site 1155071005614 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-acetyltransferase; Region: DapD_Ac; TIGR03532 1155071005615 Tetrahydrodipicolinate succinyltransferase N-terminal; Region: DapH_N; pfam08503 1155071005616 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 1155071005617 putative trimer interface [polypeptide binding]; other site 1155071005618 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 1155071005619 putative CoA binding site [chemical binding]; other site 1155071005620 putative trimer interface [polypeptide binding]; other site 1155071005621 putative CoA binding site [chemical binding]; other site 1155071005622 Class I aldolases; Region: Aldolase_Class_I; cl17187 1155071005623 catalytic residue [active] 1155071005624 PTS system glucitol/sorbitol-specific IIA component; Region: PTSIIA_gutA; pfam03829 1155071005625 Sorbitol phosphotransferase enzyme II N-terminus; Region: EIIBC-GUT_N; pfam03612 1155071005626 PTS system, glucitol/sorbitol-specific, IIBC component; Region: EIIBC-GUT; TIGR00825 1155071005627 Sorbitol phosphotransferase enzyme II C-terminus; Region: EIIBC-GUT_C; pfam07663 1155071005628 PTS system enzyme II sorbitol-specific factor; Region: EII-GUT; pfam03608 1155071005629 Glucitol operon activator protein (GutM); Region: GutM; pfam06923 1155071005630 putative frv operon regulatory protein; Provisional; Region: PRK09863 1155071005631 HTH domain; Region: HTH_11; pfam08279 1155071005632 PRD domain; Region: PRD; pfam00874 1155071005633 PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568 1155071005634 active site 1155071005635 P-loop; other site 1155071005636 phosphorylation site [posttranslational modification] 1155071005637 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 1155071005638 active site 1155071005639 phosphorylation site [posttranslational modification] 1155071005640 sorbitol-6-phosphate 2-dehydrogenase; Provisional; Region: PRK06171 1155071005641 classical (c) SDRs; Region: SDR_c; cd05233 1155071005642 NAD(P) binding site [chemical binding]; other site 1155071005643 active site 1155071005644 glucose-6-phosphate isomerase; Provisional; Region: pgi; PRK14097 1155071005645 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015 1155071005646 active site 1155071005647 dimer interface [polypeptide binding]; other site 1155071005648 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016 1155071005649 dimer interface [polypeptide binding]; other site 1155071005650 active site 1155071005651 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 1155071005652 nucleoside/Zn binding site; other site 1155071005653 dimer interface [polypeptide binding]; other site 1155071005654 catalytic motif [active] 1155071005655 Metal-dependent hydrolases of the beta-lactamase superfamily III [General function prediction only]; Region: ElaC; COG1234 1155071005656 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 1155071005657 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 1155071005658 putative active site [active] 1155071005659 Bacterial protein of unknown function (DUF925); Region: DUF925; pfam06042 1155071005660 queuine tRNA-ribosyltransferase; Provisional; Region: tgt; PRK00112 1155071005661 Queuine/archaeosine tRNA-ribosyltransferase [Translation, ribosomal structure and biogenesis]; Region: Tgt; COG0343 1155071005662 Bacteriocin class II with double-glycine leader peptide; Region: Bacteriocin_IIc; pfam10439 1155071005663 Predicted CoA-binding protein [General function prediction only]; Region: COG1832 1155071005664 DNA polymerase I; Provisional; Region: PRK05755 1155071005665 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 1155071005666 active site 1155071005667 metal binding site 1 [ion binding]; metal-binding site 1155071005668 putative 5' ssDNA interaction site; other site 1155071005669 metal binding site 3; metal-binding site 1155071005670 metal binding site 2 [ion binding]; metal-binding site 1155071005671 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 1155071005672 putative DNA binding site [nucleotide binding]; other site 1155071005673 putative metal binding site [ion binding]; other site 1155071005674 inactive DEDDy 3'-5' exonuclease domain of Bacillus stearothermophilus DNA polymerase I and similar family-A DNA polymerases; Region: DNA_polA_I_Bacillus_like_exo; cd06140 1155071005675 Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637 1155071005676 active site 1155071005677 DNA binding site [nucleotide binding] 1155071005678 catalytic site [active] 1155071005679 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1155071005680 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1155071005681 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1155071005682 Ketopantoate reductase [Coenzyme metabolism]; Region: ApbA; COG1893 1155071005683 Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558 1155071005684 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 1155071005685 LytTr DNA-binding domain; Region: LytTR; pfam04397 1155071005686 Protein of unknown function with HXXEE motif; Region: HXXEE; pfam13787 1155071005687 Arabinose-binding domain of AraC transcription regulator, N-term; Region: Arabinose_bd; pfam12625 1155071005688 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1155071005689 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1155071005690 Transketolase [Carbohydrate transport and metabolism]; Region: TktA; COG0021 1155071005691 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 1155071005692 TPP-binding site [chemical binding]; other site 1155071005693 dimer interface [polypeptide binding]; other site 1155071005694 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 1155071005695 PYR/PP interface [polypeptide binding]; other site 1155071005696 dimer interface [polypeptide binding]; other site 1155071005697 TPP binding site [chemical binding]; other site 1155071005698 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 1155071005699 putative L-ascorbate 6-phosphate lactonase; Provisional; Region: PRK11709 1155071005700 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 1155071005701 Transcriptional antiterminator [Transcription]; Region: BglG; COG3711 1155071005702 PRD domain; Region: PRD; pfam00874 1155071005703 PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568 1155071005704 active site 1155071005705 P-loop; other site 1155071005706 phosphorylation site [posttranslational modification] 1155071005707 bacteriocin secretion accessory protein; Region: bacteriocin_acc; TIGR01000 1155071005708 bacteriocin secretion accessory protein; Region: bacteriocin_acc; TIGR01000 1155071005709 A sub-family of peptidase family C39. Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various...; Region: Peptidase_C39B; cd02418 1155071005710 ABC-type bacteriocin transporter; Region: bacteriocin_ABC; TIGR01193 1155071005711 putative active site [active] 1155071005712 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1155071005713 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1155071005714 Walker A/P-loop; other site 1155071005715 ATP binding site [chemical binding]; other site 1155071005716 Q-loop/lid; other site 1155071005717 ABC transporter signature motif; other site 1155071005718 Walker B; other site 1155071005719 D-loop; other site 1155071005720 H-loop/switch region; other site 1155071005721 L-ribulose-5-phosphate 4-epimerase; Provisional; Region: araD; PRK13145 1155071005722 L-ribulose-5-phosphate 4-epimerase; Reviewed; Region: araD; PRK08193 1155071005723 intersubunit interface [polypeptide binding]; other site 1155071005724 active site 1155071005725 Zn2+ binding site [ion binding]; other site 1155071005726 putative L-xylulose 5-phosphate 3-epimerase; Reviewed; Region: PRK13210 1155071005727 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cd00019 1155071005728 AP (apurinic/apyrimidinic) site pocket; other site 1155071005729 DNA interaction; other site 1155071005730 Metal-binding active site; metal-binding site 1155071005731 3-Keto-L-gulonate 6-phosphate decarboxylase (KGPDC) and D-arabino-3-hexulose-6-phosphate synthase (HPS). KGPDC catalyzes the formation of L-xylulose 5-phosphate and carbon dioxide from 3-keto-L-gulonate 6-phosphate as part of the anaerobic pathway for...; Region: KGPDC_HPS; cd04726 1155071005732 active site 1155071005733 dimer interface [polypeptide binding]; other site 1155071005734 magnesium binding site [ion binding]; other site 1155071005735 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 1155071005736 active site 1155071005737 phosphorylation site [posttranslational modification] 1155071005738 PTS_IIB_ascorbate: subunit IIB of enzyme II (EII) of the L-ascorbate-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is an L-ascorbate-specific permease with two cytoplasmic subunits (IIA and IIB) and a...; Region: PTS_IIB_ascorbate; cd05563 1155071005739 active site 1155071005740 P-loop; other site 1155071005741 phosphorylation site [posttranslational modification] 1155071005742 PTS system ascorbate-specific transporter subunit IIC; Reviewed; Region: PRK12997 1155071005743 Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788 1155071005744 Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108 1155071005745 GDP-binding site [chemical binding]; other site 1155071005746 ACT binding site; other site 1155071005747 IMP binding site; other site 1155071005748 bifunctional glutamate--cysteine ligase/glutathione synthetase; Provisional; Region: PRK02471 1155071005749 Glutamate-cysteine ligase; Region: Glu_cys_ligase; cl17352 1155071005750 ATP-grasp domain; Region: ATP-grasp_4; cl17255 1155071005751 carbamate kinase; Reviewed; Region: PRK12686 1155071005752 AAK_CK: Carbamate kinase (CK) catalyzes both the ATP-phosphorylation of carbamate and carbamoyl phosphate (CP) utilization with the production of ATP from ADP and CP. Both CK (this CD) and nonhomologous CP synthetase synthesize carbamoyl phosphate, an...; Region: AAK_CK; cd04235 1155071005753 putative substrate binding site [chemical binding]; other site 1155071005754 nucleotide binding site [chemical binding]; other site 1155071005755 nucleotide binding site [chemical binding]; other site 1155071005756 homodimer interface [polypeptide binding]; other site 1155071005757 agmatine deiminase; Provisional; Region: PRK13551 1155071005758 agmatine deiminase; Region: agmatine_aguA; TIGR03380 1155071005759 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 1155071005760 putrescine carbamoyltransferase; Provisional; Region: PRK02255 1155071005761 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 1155071005762 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 1155071005763 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1155071005764 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1155071005765 DNA binding residues [nucleotide binding] 1155071005766 dimerization interface [polypeptide binding]; other site 1155071005767 Nitroreductase-like family 4. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_4; cd02140 1155071005768 dimer interface [polypeptide binding]; other site 1155071005769 FMN binding site [chemical binding]; other site 1155071005770 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 1155071005771 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1155071005772 Walker A/P-loop; other site 1155071005773 ATP binding site [chemical binding]; other site 1155071005774 Q-loop/lid; other site 1155071005775 ABC transporter signature motif; other site 1155071005776 Walker B; other site 1155071005777 D-loop; other site 1155071005778 H-loop/switch region; other site 1155071005779 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352 1155071005780 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 1155071005781 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1155071005782 Walker A/P-loop; other site 1155071005783 ATP binding site [chemical binding]; other site 1155071005784 Q-loop/lid; other site 1155071005785 ABC transporter signature motif; other site 1155071005786 Walker B; other site 1155071005787 D-loop; other site 1155071005788 H-loop/switch region; other site 1155071005789 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 1155071005790 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 1155071005791 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 1155071005792 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1155071005793 dimer interface [polypeptide binding]; other site 1155071005794 conserved gate region; other site 1155071005795 putative PBP binding loops; other site 1155071005796 ABC-ATPase subunit interface; other site 1155071005797 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 1155071005798 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1155071005799 dimer interface [polypeptide binding]; other site 1155071005800 conserved gate region; other site 1155071005801 putative PBP binding loops; other site 1155071005802 ABC-ATPase subunit interface; other site 1155071005803 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 1155071005804 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 1155071005805 peptide binding site [polypeptide binding]; other site 1155071005806 D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: DacC; COG1686 1155071005807 Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; smart00936 1155071005808 cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814; cl03223 1155071005809 FeS assembly protein SufB; Region: sufB; TIGR01980 1155071005810 NifU homolog involved in Fe-S cluster formation [Energy production and conversion]; Region: IscU; COG0822 1155071005811 Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664 1155071005812 trimerization site [polypeptide binding]; other site 1155071005813 active site 1155071005814 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 1155071005815 Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453 1155071005816 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1155071005817 catalytic residue [active] 1155071005818 Cysteine desulfurase activator SufB [Posttranslational modification, protein turnover, chaperones]; Region: SufB; COG0719 1155071005819 FeS assembly protein SufD; Region: sufD; TIGR01981 1155071005820 Cysteine desulfurase activator ATPase [Posttranslational modification, protein turnover, chaperones]; Region: sufC; COG0396 1155071005821 ABC-type transport system involved in Fe-S cluster assembly, ATPase component; Region: ABC_FeS_Assembly; cd03217 1155071005822 Walker A/P-loop; other site 1155071005823 ATP binding site [chemical binding]; other site 1155071005824 Q-loop/lid; other site 1155071005825 ABC transporter signature motif; other site 1155071005826 Walker B; other site 1155071005827 D-loop; other site 1155071005828 H-loop/switch region; other site 1155071005829 UDP-N-acetylmuramyl pentapeptide phosphotransferase/UDP-N- acetylglucosamine-1-phosphate transferase [Cell envelope biogenesis, outer membrane]; Region: Rfe; COG0472 1155071005830 This subfamily contains Escherichia coli WecA, Bacillus subtilis TagO and related proteins. WecA is an UDP-N-acetylglucosamine (GlcNAc):undecaprenyl-phosphate (Und-P) GlcNAc-1-phosphate transferase that catalyzes the formation of a phosphodiester bond...; Region: GT_WecA_like; cd06853 1155071005831 Mg++ binding site [ion binding]; other site 1155071005832 putative catalytic motif [active] 1155071005833 substrate binding site [chemical binding]; other site 1155071005834 adaptor protein; Provisional; Region: PRK02315 1155071005835 undecaprenyl pyrophosphate phosphatase; Reviewed; Region: PRK00281 1155071005836 Predicted membrane protein (DUF2207); Region: DUF2207; pfam09972 1155071005837 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1155071005838 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 1155071005839 substrate binding pocket [chemical binding]; other site 1155071005840 membrane-bound complex binding site; other site 1155071005841 hinge residues; other site 1155071005842 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1155071005843 dimer interface [polypeptide binding]; other site 1155071005844 conserved gate region; other site 1155071005845 putative PBP binding loops; other site 1155071005846 ABC-ATPase subunit interface; other site 1155071005847 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 1155071005848 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 1155071005849 Walker A/P-loop; other site 1155071005850 ATP binding site [chemical binding]; other site 1155071005851 Q-loop/lid; other site 1155071005852 ABC transporter signature motif; other site 1155071005853 Walker B; other site 1155071005854 D-loop; other site 1155071005855 H-loop/switch region; other site 1155071005856 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1155071005857 gallidermin-class lantibiotic protection ABC transporter, ATP-binding subunit; Region: galliderm_ABC; TIGR03740 1155071005858 Walker A/P-loop; other site 1155071005859 ATP binding site [chemical binding]; other site 1155071005860 Q-loop/lid; other site 1155071005861 ABC transporter signature motif; other site 1155071005862 Walker B; other site 1155071005863 D-loop; other site 1155071005864 H-loop/switch region; other site 1155071005865 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 1155071005866 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 1155071005867 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1155071005868 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1155071005869 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 1155071005870 A subgroup of the band 7 domain of flotillin (reggie) like proteins. This subgroup contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin. Many of these band 7 domain-containing proteins are lipid raft-associated. Individual...; Region: Band_7_4; cd03407 1155071005871 threonine dehydratase; Validated; Region: PRK08639 1155071005872 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 1155071005873 tetramer interface [polypeptide binding]; other site 1155071005874 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1155071005875 catalytic residue [active] 1155071005876 C-terminal regulatory domain of Threonine dehydratase; Region: Thr_dehydrat_C; pfam00585 1155071005877 ketol-acid reductoisomerase; Provisional; Region: PRK05479 1155071005878 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvN; pfam07991 1155071005879 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450 1155071005880 acetolactate synthase 3 regulatory subunit; Reviewed; Region: ilvH; PRK11895 1155071005881 N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878 1155071005882 putative valine binding site [chemical binding]; other site 1155071005883 dimer interface [polypeptide binding]; other site 1155071005884 Small subunit of acetolactate synthase; Region: ALS_ss_C; pfam10369 1155071005885 acetolactate synthase catalytic subunit; Reviewed; Region: PRK07282 1155071005886 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 1155071005887 PYR/PP interface [polypeptide binding]; other site 1155071005888 dimer interface [polypeptide binding]; other site 1155071005889 TPP binding site [chemical binding]; other site 1155071005890 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 1155071005891 Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015 1155071005892 TPP-binding site [chemical binding]; other site 1155071005893 dimer interface [polypeptide binding]; other site 1155071005894 DAK2 domain fusion protein YloV; Region: YloV; TIGR03599 1155071005895 DAK2 domain; Region: Dak2; pfam02734 1155071005896 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1302 1155071005897 Putative protein-S-isoprenylcysteine methyltransferase [Posttranslational modification, protein turnover, chaperones]; Region: STE14; COG2020 1155071005898 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 1155071005899 Transposase DDE domain; Region: DDE_Tnp_1_3; pfam13612 1155071005900 Domain of unknown function (DUF771); Region: DUF771; cl09962 1155071005901 phiLC3 phage and phage-related integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes various bacterial (mainly gram positive) and phage integrases, including those similar to Lactococcus...; Region: INT_phiLC3_C; cd01189 1155071005902 Int/Topo IB signature motif; other site 1155071005903 Glutamate-cysteine ligase family 2(GCS2); Region: GCS2; cl00954 1155071005904 L17 downstream element RNA motif; L17DE 1155071005905 50S ribosomal protein L17; Validated; Region: rplQ; PRK05591 1155071005906 DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182 1155071005907 N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928 1155071005908 alphaNTD homodimer interface [polypeptide binding]; other site 1155071005909 alphaNTD - beta interaction site [polypeptide binding]; other site 1155071005910 alphaNTD - beta' interaction site [polypeptide binding]; other site 1155071005911 Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118 1155071005912 30S ribosomal protein S11; Validated; Region: PRK05309 1155071005913 Ribosomal protein S13 [Translation, ribosomal structure and biogenesis]; Region: RpsM; COG0099 1155071005914 30S ribosomal protein S13; Region: bact_S13; TIGR03631 1155071005915 Ribosomal protein L36; Region: Ribosomal_L36; pfam00444 1155071005916 S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451 1155071005917 rRNA binding site [nucleotide binding]; other site 1155071005918 predicted 30S ribosome binding site; other site 1155071005919 adenylate kinase; Reviewed; Region: adk; PRK00279 1155071005920 Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428 1155071005921 AMP-binding site [chemical binding]; other site 1155071005922 ATP-AMP (Ap5A)-binding site [chemical binding]; other site 1155071005923 preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204 1155071005924 SecY translocase; Region: SecY; pfam00344 1155071005925 50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592 1155071005926 Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins that...; Region: Ribosomal_L30; cd01658 1155071005927 23S rRNA binding site [nucleotide binding]; other site 1155071005928 30S ribosomal protein S5; Validated; Region: rpsE; PRK00550 1155071005929 Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333 1155071005930 Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719 1155071005931 Ribosomal L18/L5e: L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432 1155071005932 5S rRNA interface [nucleotide binding]; other site 1155071005933 L27 interface [polypeptide binding]; other site 1155071005934 23S rRNA interface [nucleotide binding]; other site 1155071005935 L5 interface [polypeptide binding]; other site 1155071005936 50S ribosomal protein L6; Validated; Region: rplF; PRK05498 1155071005937 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 1155071005938 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 1155071005939 30S ribosomal protein S8; Validated; Region: rpsH; PRK00136 1155071005940 30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08061 1155071005941 50S ribosomal protein L5; Validated; Region: rplE; PRK00010 1155071005942 Ribosomal protein L5; Region: Ribosomal_L5; pfam00281 1155071005943 ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673 1155071005944 50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004 1155071005945 KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089 1155071005946 RNA binding site [nucleotide binding]; other site 1155071005947 50S ribosomal protein L14; Validated; Region: rplN; PRK05483 1155071005948 30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610 1155071005949 Ribosomal L29 protein/HIP. L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals. L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427 1155071005950 23S rRNA interface [nucleotide binding]; other site 1155071005951 putative translocon interaction site; other site 1155071005952 signal recognition particle (SRP54) interaction site; other site 1155071005953 L23 interface [polypeptide binding]; other site 1155071005954 trigger factor interaction site; other site 1155071005955 Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433 1155071005956 23S rRNA interface [nucleotide binding]; other site 1155071005957 5S rRNA interface [nucleotide binding]; other site 1155071005958 putative antibiotic binding site [chemical binding]; other site 1155071005959 L25 interface [polypeptide binding]; other site 1155071005960 L27 interface [polypeptide binding]; other site 1155071005961 30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310 1155071005962 K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3 is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel. The KH...; Region: 30S_S3_KH; cd02412 1155071005963 G-X-X-G motif; other site 1155071005964 Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189 1155071005965 Ribosomal protein L22/L17e. L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit. It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336 1155071005966 putative translocon binding site; other site 1155071005967 protein-rRNA interface [nucleotide binding]; other site 1155071005968 30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357 1155071005969 50S ribosomal protein L2; Validated; Region: rplB; PRK09374 1155071005970 Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181 1155071005971 Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947 1155071005972 50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738 1155071005973 50S ribosomal protein L4; Provisional; Region: rplD; PRK05319 1155071005974 50S ribosomal protein L3; Validated; Region: rplC; PRK00001 1155071005975 30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596 1155071005976 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1155071005977 SOS-response transcriptional repressors (RecA-mediated autopeptidases) [Transcription / Signal transduction mechanisms]; Region: LexA; COG1974 1155071005978 non-specific DNA binding site [nucleotide binding]; other site 1155071005979 salt bridge; other site 1155071005980 sequence-specific DNA binding site [nucleotide binding]; other site 1155071005981 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 1155071005982 Catalytic site [active] 1155071005983 KxYKxGKxW signal peptide; Region: KxYKxGKxW; TIGR03715 1155071005984 Glycosyl hydrolase family 68, includes levansucrase, beta-fructofuranosidase and inulosucrase; Region: GH68; cd08997 1155071005985 active site 1155071005986 ATP-binding subunits of Clp protease and DnaK/DnaJ chaperones [Posttranslational modification, protein turnover, chaperones]; Region: clpA; COG0542 1155071005987 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1155071005988 Walker A motif; other site 1155071005989 ATP binding site [chemical binding]; other site 1155071005990 Walker B motif; other site 1155071005991 arginine finger; other site 1155071005992 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1155071005993 Walker A motif; other site 1155071005994 ATP binding site [chemical binding]; other site 1155071005995 Walker B motif; other site 1155071005996 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 1155071005997 Firmicute transcriptional repressor of class III stress genes (CtsR); Region: CtsR; pfam05848 1155071005998 elongation factor Ts; Provisional; Region: tsf; PRK09377 1155071005999 UBA/TS-N domain; Region: UBA; pfam00627 1155071006000 Elongation factor TS; Region: EF_TS; pfam00889 1155071006001 Elongation factor TS; Region: EF_TS; pfam00889 1155071006002 Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425 1155071006003 rRNA interaction site [nucleotide binding]; other site 1155071006004 S8 interaction site; other site 1155071006005 putative laminin-1 binding site; other site 1155071006006 Predicted integral membrane protein [Function unknown]; Region: COG5617 1155071006007 Microcin C7 self-immunity protein determines resistance to exogenous microcin C7; Region: Peptidase_S66_mccF_like; cd07062 1155071006008 putative dimer interface [polypeptide binding]; other site 1155071006009 catalytic triad [active] 1155071006010 Predicted metalloendopeptidase [Posttranslational modification, protein turnover, chaperones]; Region: PepO; COG3590 1155071006011 Peptidase family M13 includes neprilysin, endothelin-converting enzyme I; Region: M13; cd08662 1155071006012 active site 1155071006013 Zn binding site [ion binding]; other site 1155071006014 alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403 1155071006015 Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333 1155071006016 Ca binding site [ion binding]; other site 1155071006017 active site 1155071006018 catalytic site [active] 1155071006019 Domain of unknown function (DUF3459); Region: DUF3459; pfam11941 1155071006020 PTS system, trehalose-specific IIBC component; Region: PTS-IIBC-Tre; TIGR01992 1155071006021 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 1155071006022 active site turn [active] 1155071006023 phosphorylation site [posttranslational modification] 1155071006024 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 1155071006025 Phosphotransferase system IIA components [Carbohydrate transport and metabolism]; Region: NagE; COG2190 1155071006026 HPr interaction site; other site 1155071006027 glycerol kinase (GK) interaction site [polypeptide binding]; other site 1155071006028 active site 1155071006029 phosphorylation site [posttranslational modification] 1155071006030 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1155071006031 DNA-binding site [nucleotide binding]; DNA binding site 1155071006032 trehalose operon repressor, B. subtilis-type; Region: trehalos_R_Bsub; TIGR02404 1155071006033 UTRA domain; Region: UTRA; pfam07702 1155071006034 Glycosyl hydrolase family 66; Region: Glyco_hydro_66; pfam13199 1155071006035 D-Tyrosyl-tRNAtyr deacylases; a class of tRNA-dependent hydrolases which are capable of hydrolyzing the ester bond of D-Tyrosyl-tRNA reducing the level of cellular D-Tyrosine while recycling the peptidyl-tRNA; found in bacteria and in eukaryotes but not...; Region: Dtyr_deacylase; cd00563 1155071006036 putative active site [active] 1155071006037 dimerization interface [polypeptide binding]; other site 1155071006038 putative tRNAtyr binding site [nucleotide binding]; other site 1155071006039 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 1155071006040 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1155071006041 Zn2+ binding site [ion binding]; other site 1155071006042 Mg2+ binding site [ion binding]; other site 1155071006043 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 1155071006044 synthetase active site [active] 1155071006045 NTP binding site [chemical binding]; other site 1155071006046 metal binding site [ion binding]; metal-binding site 1155071006047 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 1155071006048 ACT domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876 1155071006049 Streptococcus agalactiae RgfB, part of a putative two component signal transduction system, and related proteins; Region: RgfB-like; cd09079 1155071006050 putative catalytic site [active] 1155071006051 putative metal binding site [ion binding]; other site 1155071006052 putative phosphate binding site [ion binding]; other site 1155071006053 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 1155071006054 PTS system, IIBC component; Region: PTS-II-BC-unk1; TIGR02003 1155071006055 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 1155071006056 active site turn [active] 1155071006057 phosphorylation site [posttranslational modification] 1155071006058 Phosphotransferase system IIA components [Carbohydrate transport and metabolism]; Region: NagE; COG2190 1155071006059 HPr interaction site; other site 1155071006060 glycerol kinase (GK) interaction site [polypeptide binding]; other site 1155071006061 active site 1155071006062 phosphorylation site [posttranslational modification] 1155071006063 disrupted protein; putative pseudogene 1155071006064 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1385 1155071006065 RNA methyltransferase, RsmE family; Region: TIGR00046 1155071006066 Ribosomal protein L11 methyltransferase (PrmA); Region: PrmA; pfam06325 1155071006067 Methyltransferase domain; Region: Methyltransf_18; pfam12847 1155071006068 Protein of unknown function (DUF3013); Region: DUF3013; pfam11217 1155071006069 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 1155071006070 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1155071006071 Coenzyme A binding pocket [chemical binding]; other site 1155071006072 recombination factor protein RarA; Reviewed; Region: PRK13342 1155071006073 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1155071006074 Walker A motif; other site 1155071006075 ATP binding site [chemical binding]; other site 1155071006076 Walker B motif; other site 1155071006077 arginine finger; other site 1155071006078 MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002 1155071006079 heavy metal-(Cd/Co/Hg/Pb/Zn)-translocating P-type ATPase; Region: ATPase-IB2_Cd; TIGR01512 1155071006080 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 1155071006081 Soluble P-type ATPase [General function prediction only]; Region: COG4087 1155071006082 Helix-Turn-Helix DNA binding domain of the BmrR transcription regulator; Region: HTH_BmrR; cd01107 1155071006083 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 1155071006084 DNA binding residues [nucleotide binding] 1155071006085 drug binding residues [chemical binding]; other site 1155071006086 dimer interface [polypeptide binding]; other site 1155071006087 Predicted membrane protein [Function unknown]; Region: COG2855 1155071006088 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1155071006089 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1155071006090 C-terminal substrate binding domain of LysR-type transcriptional regulator CysL, which activates the transcription of the cysJI operon encoding sulfite reductase, contains the type 2 periplasmic binding fold; Region: PBP2_CysL_like; cd08420 1155071006091 putative dimerization interface [polypeptide binding]; other site 1155071006092 ferrochelatase; Reviewed; Region: hemH; PRK00035 1155071006093 Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411 1155071006094 C-terminal domain interface [polypeptide binding]; other site 1155071006095 active site 1155071006096 Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419 1155071006097 active site 1155071006098 N-terminal domain interface [polypeptide binding]; other site 1155071006099 Bacterial membrane protein YfhO; Region: YfhO; pfam09586 1155071006100 UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247 1155071006101 UDP-glucose 4-epimerase; Region: PLN02240 1155071006102 NAD binding site [chemical binding]; other site 1155071006103 homodimer interface [polypeptide binding]; other site 1155071006104 active site 1155071006105 substrate binding site [chemical binding]; other site 1155071006106 Bacterial membrane protein YfhO; Region: YfhO; pfam09586 1155071006107 undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714 1155071006108 Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187 1155071006109 Ligand binding site; other site 1155071006110 Putative Catalytic site; other site 1155071006111 DXD motif; other site 1155071006112 Collagen binding domain; Region: Collagen_bind; pfam05737 1155071006113 LPXTG-motif cell wall anchor domain; Region: LPXTG_anchor; TIGR01167 1155071006114 disrupted Cnm; putative pseudogene 1155071006115 Collagen binding domain; Region: Collagen_bind; pfam05737 1155071006116 Cna protein B-type domain; Region: Cna_B; pfam05738 1155071006117 zinc transporter ZupT; Provisional; Region: PRK04201 1155071006118 ZIP Zinc transporter; Region: Zip; pfam02535 1155071006119 hypothetical protein; Validated; Region: PRK02101 1155071006120 4Fe-4S single cluster domain; Region: Fer4_12; pfam13353 1155071006121 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1155071006122 FeS/SAM binding site; other site 1155071006123 Predicted acetyltransferase [General function prediction only]; Region: COG3981 1155071006124 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 1155071006125 Coenzyme A binding pocket [chemical binding]; other site 1155071006126 anaerobic ribonucleoside triphosphate reductase; Provisional; Region: PRK09263 1155071006127 ATP cone domain; Region: ATP-cone; pfam03477 1155071006128 Class III ribonucleotide reductase; Region: RNR_III; cd01675 1155071006129 effector binding site; other site 1155071006130 active site 1155071006131 Zn binding site [ion binding]; other site 1155071006132 glycine loop; other site 1155071006133 Predicted membrane protein (DUF2079); Region: DUF2079; pfam09852 1155071006134 hypothetical protein; Provisional; Region: PRK13678 1155071006135 Holliday junction resolvase-like protein; Reviewed; Region: PRK00109 1155071006136 hypothetical protein; Provisional; Region: PRK05473 1155071006137 LytTr DNA-binding domain; Region: LytTR; smart00850 1155071006138 Protein of unknown function (DUF3021); Region: DUF3021; pfam11457 1155071006139 Arsenate Reductase (ArsC) family, Spx subfamily; Spx is a unique RNA polymerase (RNAP)-binding protein present in bacilli and some mollicutes. It inhibits transcription by binding to the C-terminal domain of the alpha subunit of RNAP, disrupting complex...; Region: ArsC_Spx; cd03032 1155071006140 ArsC family; Region: ArsC; pfam03960 1155071006141 putative catalytic residues [active] 1155071006142 thiol/disulfide switch; other site 1155071006143 recombinase A; Provisional; Region: recA; PRK09354 1155071006144 RecA is a bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response. RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983 1155071006145 hexamer interface [polypeptide binding]; other site 1155071006146 Walker A motif; other site 1155071006147 ATP binding site [chemical binding]; other site 1155071006148 Walker B motif; other site 1155071006149 competence damage-inducible protein A; Provisional; Region: PRK00549 1155071006150 Competence-damaged protein. CinA is the first gene in the competence- inducible (cin) operon and is thought to be specifically required at some stage in the process of transformation. This domain is closely related to a domain, found in a variety of...; Region: cinA; cd00885 1155071006151 putative MPT binding site; other site 1155071006152 Uncharacterized protein (competence- and mitomycin-induced) [General function prediction only]; Region: CinA; COG1546 1155071006153 Methyladenine glycosylase; Region: Adenine_glyco; pfam03352 1155071006154 Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116 1155071006155 RuvA N terminal domain; Region: RuvA_N; pfam01330 1155071006156 DNA mismatch repair protein; Reviewed; Region: mutL; PRK00095 1155071006157 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1155071006158 ATP binding site [chemical binding]; other site 1155071006159 Mg2+ binding site [ion binding]; other site 1155071006160 G-X-G motif; other site 1155071006161 MutL_Trans: transducer domain, having a ribosomal S5 domain 2-like fold, conserved in the C-terminal domain of DNA mismatch repair (MutL/MLH1/PMS2) family. This transducer domain is homologous to the second domain of the DNA gyrase B subunit, which is...; Region: MutL_Trans; cd00782 1155071006162 ATP binding site [chemical binding]; other site 1155071006163 MutL C terminal dimerisation domain; Region: MutL_C; pfam08676 1155071006164 DNA mismatch repair protein MutS; Provisional; Region: PRK05399 1155071006165 MutS domain I; Region: MutS_I; pfam01624 1155071006166 MutS domain II; Region: MutS_II; pfam05188 1155071006167 MutS domain III; Region: MutS_III; pfam05192 1155071006168 ATP-binding cassette domain of MutS1 homolog; Region: ABC_MutS1; cd03284 1155071006169 Walker A/P-loop; other site 1155071006170 ATP binding site [chemical binding]; other site 1155071006171 Q-loop/lid; other site 1155071006172 ABC transporter signature motif; other site 1155071006173 Walker B; other site 1155071006174 D-loop; other site 1155071006175 H-loop/switch region; other site 1155071006176 Protein of unknown function (DUF964); Region: DUF964; cl01483 1155071006177 Arginine repressor, DNA binding domain; Region: Arg_repressor; pfam01316 1155071006178 arginine repressor; Region: argR_whole; TIGR01529 1155071006179 Arginine repressor, C-terminal domain; Region: Arg_repressor_C; pfam02863 1155071006180 arginine-ornithine antiporter; Region: arg_ornith_anti; TIGR03810 1155071006181 carbamate kinase; Reviewed; Region: PRK12686 1155071006182 AAK_CK: Carbamate kinase (CK) catalyzes both the ATP-phosphorylation of carbamate and carbamoyl phosphate (CP) utilization with the production of ATP from ADP and CP. Both CK (this CD) and nonhomologous CP synthetase synthesize carbamoyl phosphate, an...; Region: AAK_CK; cd04235 1155071006183 putative substrate binding site [chemical binding]; other site 1155071006184 nucleotide binding site [chemical binding]; other site 1155071006185 nucleotide binding site [chemical binding]; other site 1155071006186 homodimer interface [polypeptide binding]; other site 1155071006187 ornithine carbamoyltransferase; Validated; Region: PRK02102 1155071006188 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 1155071006189 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 1155071006190 arginine deiminase; Provisional; Region: PRK01388 1155071006191 potential frameshift: common BLAST hit: gi|251783164|ref|YP_002997469.1| transposase 1155071006192 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 1155071006193 Transposase DDE domain; Region: DDE_Tnp_1_3; pfam13612 1155071006194 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 1155071006195 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 1155071006196 ligand binding site [chemical binding]; other site 1155071006197 flexible hinge region; other site 1155071006198 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cl17320 1155071006199 B3/4 domain; Region: B3_4; pfam03483 1155071006200 Solo B3/4 domain (OB-fold DNA/RNA-binding) of Phe-aaRS-beta [General function prediction only]; Region: COG3382 1155071006201 Arginine repressor, C-terminal domain; Region: Arg_repressor_C; pfam02863 1155071006202 arginyl-tRNA synthetase; Reviewed; Region: PRK12451 1155071006203 Arginyl tRNA synthetase N terminal dom; Region: Arg_tRNA_synt_N; smart01016 1155071006204 catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671 1155071006205 active site 1155071006206 HIGH motif; other site 1155071006207 KMSK motif region; other site 1155071006208 Anticodon-binding domain of arginyl tRNA synthetases; Region: Anticodon_Ia_Arg; cd07956 1155071006209 tRNA binding surface [nucleotide binding]; other site 1155071006210 anticodon binding site; other site 1155071006211 Uncharacterized conserved protein [Function unknown]; Region: COG1284 1155071006212 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 1155071006213 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 1155071006214 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 1155071006215 Uncharacterized conserved protein [Function unknown]; Region: COG1284 1155071006216 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 1155071006217 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 1155071006218 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 1155071006219 aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476 1155071006220 EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317 1155071006221 dimer interface [polypeptide binding]; other site 1155071006222 anticodon binding site; other site 1155071006223 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777 1155071006224 homodimer interface [polypeptide binding]; other site 1155071006225 motif 1; other site 1155071006226 active site 1155071006227 motif 2; other site 1155071006228 GAD domain; Region: GAD; pfam02938 1155071006229 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777 1155071006230 motif 3; other site 1155071006231 histidyl-tRNA synthetase; Reviewed; Region: hisS; PRK00037 1155071006232 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 1155071006233 dimer interface [polypeptide binding]; other site 1155071006234 motif 1; other site 1155071006235 active site 1155071006236 motif 2; other site 1155071006237 HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859 1155071006238 anticodon binding site; other site 1155071006239 Amino acid permease; Region: AA_permease_2; pfam13520 1155071006240 50S ribosomal protein L32; Validated; Region: rpmF; PRK01110 1155071006241 50S ribosomal protein L33; Validated; Region: rpmG; PRK00595 1155071006242 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1155071006243 dimerization interface [polypeptide binding]; other site 1155071006244 putative DNA binding site [nucleotide binding]; other site 1155071006245 putative Zn2+ binding site [ion binding]; other site 1155071006246 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1155071006247 putative substrate translocation pore; other site 1155071006248 FtsX-like permease family; Region: FtsX; pfam02687 1155071006249 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 1155071006250 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 1155071006251 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 1155071006252 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 1155071006253 Walker A/P-loop; other site 1155071006254 ATP binding site [chemical binding]; other site 1155071006255 Q-loop/lid; other site 1155071006256 ABC transporter signature motif; other site 1155071006257 Walker B; other site 1155071006258 D-loop; other site 1155071006259 H-loop/switch region; other site 1155071006260 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 1155071006261 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Streptococcus aureus MepA; Region: MATE_MepA_like; cd13143 1155071006262 A-factor biosynthesis hotdog domain; Region: AfsA; pfam03756 1155071006263 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1155071006264 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1155071006265 Transcriptional regulator C-terminal region; Region: TetR_C_8; pfam14278 1155071006266 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221 1155071006267 putative transposase OrfB; Reviewed; Region: PHA02517 1155071006268 HTH-like domain; Region: HTH_21; pfam13276 1155071006269 Integrase core domain; Region: rve; pfam00665 1155071006270 Integrase core domain; Region: rve_3; cl15866 1155071006271 potential frameshift: common BLAST hit: gi|94992689|ref|YP_600788.1| transposase 1155071006272 Integrase core domain; Region: rve; pfam00665 1155071006273 Integrase core domain; Region: rve_3; pfam13683 1155071006274 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 1155071006275 UDP-glucose LOS-beta-1,4 glucosyltransferase is required for biosynthesis of lipooligosaccharide; Region: Beta4Glucosyltransferase; cd02511 1155071006276 putative metal binding site; other site 1155071006277 Protein of unknown function (DUF3884); Region: DUF3884; pfam13024 1155071006278 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1155071006279 catalytic core [active] 1155071006280 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 1155071006281 Helix-Turn-Helix DNA binding domain of the MerR-like transcription regulators YyaN and YraB; Region: HTH_YyaN; cd01109 1155071006282 DNA binding residues [nucleotide binding] 1155071006283 putative dimer interface [polypeptide binding]; other site 1155071006284 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 1155071006285 classical (c) SDRs; Region: SDR_c; cd05233 1155071006286 NAD(P) binding site [chemical binding]; other site 1155071006287 active site 1155071006288 ABC-type proline/glycine betaine transport systems, ATPase components [Amino acid transport and metabolism]; Region: OpuBA; COG1125 1155071006289 ATP-binding cassette domain of the osmoprotectant transporter; Region: ABC_OpuCA_Osmoprotection; cd03295 1155071006290 Walker A/P-loop; other site 1155071006291 ATP binding site [chemical binding]; other site 1155071006292 Q-loop/lid; other site 1155071006293 ABC transporter signature motif; other site 1155071006294 Walker B; other site 1155071006295 D-loop; other site 1155071006296 H-loop/switch region; other site 1155071006297 FOG: CBS domain [General function prediction only]; Region: COG0517 1155071006298 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in association with the ABC transporter OpuCA. OpuCA is the ATP binding component of a bacterial solute transporter that serves a protective role to cells growing...; Region: CBS_pair_ABC_OpuCA_assoc2; cd04583 1155071006299 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1155071006300 dimer interface [polypeptide binding]; other site 1155071006301 conserved gate region; other site 1155071006302 putative PBP binding loops; other site 1155071006303 ABC-ATPase subunit interface; other site 1155071006304 ABC-type proline/glycine betaine transport systems, periplasmic components [Amino acid transport and metabolism]; Region: ProX; cl17891 1155071006305 Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069 1155071006306 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1155071006307 dimer interface [polypeptide binding]; other site 1155071006308 conserved gate region; other site 1155071006309 ABC-ATPase subunit interface; other site 1155071006310 Alkyladenine DNA glycosylase catalyzes the first step in base excision repair; Region: AAG; cd00540 1155071006311 active site 1155071006312 DNA binding site [nucleotide binding] 1155071006313 YCII-related domain; Region: YCII; cl00999 1155071006314 Predicted transcriptional regulators [Transcription]; Region: COG1733 1155071006315 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 1155071006316 Phosphorylase superfamily; Region: PNP_UDP_1; pfam01048 1155071006317 NAD-dependent aldehyde dehydrogenases [Energy production and conversion]; Region: PutA; COG1012 1155071006318 Mycobacterium tuberculosis succinate-semialdehyde dehydrogenase 1-like; Region: ALDH_SSADH1_GabD1; cd07100 1155071006319 NAD(P) binding site [chemical binding]; other site 1155071006320 catalytic residues [active] 1155071006321 dihydroxy-acid dehydratase; Provisional; Region: PRK00911 1155071006322 Domain of unknown function DUF59; Region: DUF59; cl00941 1155071006323 C4-dicarboxylate transporters of the Tellurite-resistance/Dicarboxylate Transporter (TDT) family; Region: TDT_C4-dicarb_trans; cd09325 1155071006324 gating phenylalanine in ion channel; other site 1155071006325 Predicted membrane protein [Function unknown]; Region: COG1511 1155071006326 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061 1155071006327 X-X-X-Leu-X-X-Gly heptad repeats; Region: xxxLxxG_by_4; TIGR03057 1155071006328 YhgE/Pip C-terminal domain; Region: pip_yhgE_Cterm; TIGR03062 1155071006329 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1155071006330 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1155071006331 30S ribosomal protein S4; Validated; Region: rpsD; PRK05327 1155071006332 Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163 1155071006333 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1155071006334 RNA binding surface [nucleotide binding]; other site 1155071006335 Uncharacterized protein conserved in bacteria [Function unknown]; Region: Veg; COG4466 1155071006336 replicative DNA helicase; Provisional; Region: PRK05748 1155071006337 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 1155071006338 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 1155071006339 Walker A motif; other site 1155071006340 ATP binding site [chemical binding]; other site 1155071006341 Walker B motif; other site 1155071006342 DNA binding loops [nucleotide binding] 1155071006343 50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137 1155071006344 Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281 1155071006345 Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948 1155071006346 Predicted signaling protein consisting of a modified GGDEF domain and a DHH domain [Signal transduction mechanisms]; Region: COG3887 1155071006347 DHH family; Region: DHH; pfam01368 1155071006348 DHHA1 domain; Region: DHHA1; pfam02272 1155071006349 tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA; Validated; Region: PRK05192 1155071006350 tRNA:m(5)U-54 methyltransferase; Region: gid_trmFO; TIGR00137 1155071006351 GidA associated domain 3; Region: GIDA_assoc_3; pfam13932 1155071006352 hypothetical protein; Provisional; Region: PRK09273 1155071006353 Ribose/Galactose Isomerase; Region: LacAB_rpiB; pfam02502 1155071006354 Predicted tRNA(5-methylaminomethyl-2-thiouridylate) methyltransferase, contains the PP-loop ATPase domain [Translation, ribosomal structure and biogenesis]; Region: TrmU; COG0482 1155071006355 tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998 1155071006356 Transglycosylase-like domain; Region: Transglycosylas; pfam06737 1155071006357 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1155071006358 ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619 1155071006359 cobalt transporter ATP-binding subunit; Provisional; Region: cbiO; PRK13649 1155071006360 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 1155071006361 Walker A/P-loop; other site 1155071006362 ATP binding site [chemical binding]; other site 1155071006363 Q-loop/lid; other site 1155071006364 ABC transporter signature motif; other site 1155071006365 Walker B; other site 1155071006366 D-loop; other site 1155071006367 H-loop/switch region; other site 1155071006368 cobalt transporter ATP-binding subunit; Provisional; Region: cbiO; PRK13650 1155071006369 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 1155071006370 Walker A/P-loop; other site 1155071006371 ATP binding site [chemical binding]; other site 1155071006372 Q-loop/lid; other site 1155071006373 ABC transporter signature motif; other site 1155071006374 Walker B; other site 1155071006375 D-loop; other site 1155071006376 H-loop/switch region; other site 1155071006377 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453 1155071006378 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1155071006379 non-specific DNA binding site [nucleotide binding]; other site 1155071006380 salt bridge; other site 1155071006381 sequence-specific DNA binding site [nucleotide binding]; other site 1155071006382 Domain of unknown function (DUF4115); Region: DUF4115; pfam13464 1155071006383 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 1155071006384 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 1155071006385 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 1155071006386 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 1155071006387 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 1155071006388 S4 domain protein YaaA; Region: YaaA_near_RecF; TIGR02988 1155071006389 recombination protein F; Reviewed; Region: recF; PRK00064 1155071006390 ATP-binding cassette domain of RecF; Region: ABC_RecF; cd03242 1155071006391 Walker A/P-loop; other site 1155071006392 ATP binding site [chemical binding]; other site 1155071006393 Q-loop/lid; other site 1155071006394 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1155071006395 ABC transporter signature motif; other site 1155071006396 Walker B; other site 1155071006397 D-loop; other site 1155071006398 H-loop/switch region; other site 1155071006399 inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567 1155071006400 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 1155071006401 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein. IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a...; Region: CBS_pair_IMPDH; cd04601 1155071006402 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 1155071006403 active site 1155071006404 tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282 1155071006405 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 1155071006406 active site 1155071006407 HIGH motif; other site 1155071006408 dimer interface [polypeptide binding]; other site 1155071006409 KMSKS motif; other site 1155071006410 ABC transporter ATP-binding protein; Provisional; Region: PRK15064 1155071006411 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1155071006412 Walker A/P-loop; other site 1155071006413 ATP binding site [chemical binding]; other site 1155071006414 Q-loop/lid; other site 1155071006415 ABC transporter signature motif; other site 1155071006416 Walker B; other site 1155071006417 D-loop; other site 1155071006418 H-loop/switch region; other site 1155071006419 ABC transporter; Region: ABC_tran_2; pfam12848 1155071006420 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1155071006421 Bacterial membrane protein YfhO; Region: YfhO; pfam09586 1155071006422 Protein of unknown function (DUF1275); Region: DUF1275; pfam06912 1155071006423 rRNA large subunit methyltransferase; Provisional; Region: PRK00103 1155071006424 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 1155071006425 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 1155071006426 protein binding site [polypeptide binding]; other site 1155071006427 ParB/RepB/Spo0J family partition protein; Region: parB_part; TIGR00180 1155071006428 ParB-like nuclease domain; Region: ParBc; pfam02195